                         SEQUENCE LISTING

<110> AGENSYS, INC.
      SEATTLE GENETICS, INC.

<120> PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-191P4D12 ANTIBODY 
      DRUG CONJUGATES AND METHODS OF USE THEREOF

<130> 14369-244-228

<140>
<141>

<150> US 62/774,819
<151> 2018-12-03

<160> 23

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 3464
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (264)...(1796)

<220> 
<221> misc_feature   
<222> (1)...(3464)
<223> 191P4D12

<400> 1
ggccgtcgtt gttggccaca gcgtgggaag cagctctggg ggagctcgga gctcccgatc 60
acggcttctt gggggtagct acggctgggt gtgtagaacg gggccggggc tggggctggg 120
tcccctagtg gagacccaag tgcgagaggc aagaactctg cagcttcctg ccttctgggt 180
cagttcctta ttcaagtctg cagccggctc ccagggagat ctcggtggaa cttcagaaac 240
gctgggcagt ctgcctttca acc atg ccc ctg tcc ctg gga gcc gag atg tgg 293
                          Met Pro Leu Ser Leu Gly Ala Glu Met Trp
                           1               5                   10
 
ggg cct gag gcc tgg ctg ctg ctg ctg cta ctg ctg gca tca ttt aca   341
Gly Pro Glu Ala Trp Leu Leu Leu Leu Leu Leu Leu Ala Ser Phe Thr
                 15                  20                  25
 
ggc cgg tgc ccc gcg ggt gag ctg gag acc tca gac gtg gta act gtg   389
Gly Arg Cys Pro Ala Gly Glu Leu Glu Thr Ser Asp Val Val Thr Val
             30                  35                  40
 
gtg ctg ggc cag gac gca aaa ctg ccc tgc ttc tac cga ggg gac tcc   437
Val Leu Gly Gln Asp Ala Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser
         45                  50                  55
 
ggc gag caa gtg ggg caa gtg gca tgg gct cgg gtg gac gcg ggc gaa   485
Gly Glu Gln Val Gly Gln Val Ala Trp Ala Arg Val Asp Ala Gly Glu
     60                  65                  70
 
ggc gcc cag gaa cta gcg cta ctg cac tcc aaa tac ggg ctt cat gtg   533
Gly Ala Gln Glu Leu Ala Leu Leu His Ser Lys Tyr Gly Leu His Val
 75                  80                  85                  90
 
agc ccg gct tac gag ggc cgc gtg gag cag ccg ccg ccc cca cgc aac   581
Ser Pro Ala Tyr Glu Gly Arg Val Glu Gln Pro Pro Pro Pro Arg Asn
                 95                 100                 105
 
ccc ctg gac ggc tca gtg ctc ctg cgc aac gca gtg cag gcg gat gag   629
Pro Leu Asp Gly Ser Val Leu Leu Arg Asn Ala Val Gln Ala Asp Glu
            110                 115                 120
 
ggc gag tac gag tgc cgg gtc agc acc ttc ccc gcc ggc agc ttc cag   677
Gly Glu Tyr Glu Cys Arg Val Ser Thr Phe Pro Ala Gly Ser Phe Gln
        125                 130                 135
 
gcg cgg ctg cgg ctc cga gtg ctg gtg cct ccc ctg ccc tca ctg aat   725
Ala Arg Leu Arg Leu Arg Val Leu Val Pro Pro Leu Pro Ser Leu Asn
    140                 145                 150
 
cct ggt cca gca cta gaa gag ggc cag ggc ctg acc ctg gca gcc tcc   773
Pro Gly Pro Ala Leu Glu Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser
155                 160                 165                 170
 
tgc aca gct gag ggc agc cca gcc ccc agc gtg acc tgg gac acg gag   821
Cys Thr Ala Glu Gly Ser Pro Ala Pro Ser Val Thr Trp Asp Thr Glu
                175                 180                 185
 
gtc aaa ggc aca acg tcc agc cgt tcc ttc aag cac tcc cgc tct gct   869
Val Lys Gly Thr Thr Ser Ser Arg Ser Phe Lys His Ser Arg Ser Ala
            190                 195                 200
 
gcc gtc acc tca gag ttc cac ttg gtg cct agc cgc agc atg aat ggg   917
Ala Val Thr Ser Glu Phe His Leu Val Pro Ser Arg Ser Met Asn Gly
        205                 210                 215
 
cag cca ctg act tgt gtg gtg tcc cat cct ggc ctg ctc cag gac caa   965
Gln Pro Leu Thr Cys Val Val Ser His Pro Gly Leu Leu Gln Asp Gln
    220                 225                 230
 
agg atc acc cac atc ctc cac gtg tcc ttc ctt gct gag gcc tct gtg   1013
Arg Ile Thr His Ile Leu His Val Ser Phe Leu Ala Glu Ala Ser Val
235                 240                 245                 250
 
agg ggc ctt gaa gac caa aat ctg tgg cac att ggc aga gaa gga gct   1061
Arg Gly Leu Glu Asp Gln Asn Leu Trp His Ile Gly Arg Glu Gly Ala
                255                 260                 265
 
atg ctc aag tgc ctg agt gaa ggg cag ccc cct ccc tca tac aac tgg   1109
Met Leu Lys Cys Leu Ser Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp
            270                 275                 280
 
aca cgg ctg gat ggg cct ctg ccc agt ggg gta cga gtg gat ggg gac   1157
Thr Arg Leu Asp Gly Pro Leu Pro Ser Gly Val Arg Val Asp Gly Asp
        285                 290                 295
 
act ttg ggc ttt ccc cca ctg acc act gag cac agc ggc atc tac gtc   1205
Thr Leu Gly Phe Pro Pro Leu Thr Thr Glu His Ser Gly Ile Tyr Val
    300                 305                 310
 
tgc cat gtc agc aat gag ttc tcc tca agg gat tct cag gtc act gtg   1253
Cys His Val Ser Asn Glu Phe Ser Ser Arg Asp Ser Gln Val Thr Val
315                 320                 325                 330
 
gat gtt ctt gac ccc cag gaa gac tct ggg aag cag gtg gac cta gtg   1301
Asp Val Leu Asp Pro Gln Glu Asp Ser Gly Lys Gln Val Asp Leu Val
                335                 340                 345
 
tca gcc tcg gtg gtg gtg gtg ggt gtg atc gcc gca ctc ttg ttc tgc   1349
Ser Ala Ser Val Val Val Val Gly Val Ile Ala Ala Leu Leu Phe Cys
            350                 355                 360
 
ctt ctg gtg gtg gtg gtg gtg ctc atg tcc cga tac cat cgg cgc aag   1397
Leu Leu Val Val Val Val Val Leu Met Ser Arg Tyr His Arg Arg Lys
        365                 370                 375
 
gcc cag cag atg acc cag aaa tat gag gag gag ctg acc ctg acc agg   1445
Ala Gln Gln Met Thr Gln Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg
    380                 385                 390
 
gag aac tcc atc cgg agg ctg cat tcc cat cac acg gac ccc agg agc   1493
Glu Asn Ser Ile Arg Arg Leu His Ser His His Thr Asp Pro Arg Ser
395                 400                 405                 410
 
cag ccg gag gag agt gta ggg ctg aga gcc gag ggc cac cct gat agt   1541
Gln Pro Glu Glu Ser Val Gly Leu Arg Ala Glu Gly His Pro Asp Ser
                415                 420                 425
 
ctc aag gac aac agt agc tgc tct gtg atg agt gaa gag ccc gag ggc   1589
Leu Lys Asp Asn Ser Ser Cys Ser Val Met Ser Glu Glu Pro Glu Gly
            430                 435                 440
 
cgc agt tac tcc acg ctg acc acg gtg agg gag ata gaa aca cag act   1637
Arg Ser Tyr Ser Thr Leu Thr Thr Val Arg Glu Ile Glu Thr Gln Thr
        445                 450                 455
 
gaa ctg ctg tct cca ggc tct ggg cgg gcc gag gag gag gaa gat cag   1685
Glu Leu Leu Ser Pro Gly Ser Gly Arg Ala Glu Glu Glu Glu Asp Gln
    460                 465                 470
 
gat gaa ggc atc aaa cag gcc atg aac cat ttt gtt cag gag aat ggg   1733
Asp Glu Gly Ile Lys Gln Ala Met Asn His Phe Val Gln Glu Asn Gly
475                 480                 485                 490
 
acc cta cgg gcc aag ccc acg ggc aat ggc atc tac atc aat ggg cgg   1781
Thr Leu Arg Ala Lys Pro Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg
                495                 500                 505
 
gga cac ctg gtc tga cccaggcctg cctcccttcc ctaggcctgg ctccttctgt   1836
Gly His Leu Val  
            510
 
tgacatggga gattttagct catcttgggg gcctccttaa acacccccat ttcttgcgga 1896
agatgctccc catcccactg actgcttgac ctttacctcc aacccttctg ttcatcggga 1956
gggctccacc aattgagtct ctcccaccat gcatgcaggt cactgtgtgt gtgcatgtgt 2016
gcctgtgtga gtgttgactg actgtgtgtg tgtggagggg tgactgtccg tggaggggtg 2076
actgtgtccg tggtgtgtat tatgctgtca tatcagagtc aagtgaactg tggtgtatgt 2136
gccacgggat ttgagtggtt gcgtgggcaa cactgtcagg gtttggcgtg tgtgtcatgt 2196
ggctgtgtgt gacctctgcc tgaaaaagca ggtattttct cagaccccag agcagtatta 2256
atgatgcaga ggttggagga gagaggtgga gactgtggct cagacccagg tgtgcgggca 2316
tagctggagc tggaatctgc ctccggtgtg agggaacctg tctcctacca cttcggagcc 2376
atgggggcaa gtgtgaagca gccagtccct gggtcagcca gaggcttgaa ctgttacaga 2436
agccctctgc cctctggtgg cctctgggcc tgctgcatgt acatattttc tgtaaatata 2496
catgcgccgg gagcttcttg caggaatact gctccgaatc acttttaatt tttttctttt 2556
ttttttcttg ccctttccat tagttgtatt ttttatttat ttttattttt attttttttt 2616
agagatggag tctcactatg ttgctcaggc tggccttgaa ctcctgggct caagcaatcc 2676
tcctgcctca gcctccctag tagctgggac tttaagtgta caccactgtg cctgctttga 2736
atcctttacg aagagaaaaa aaaaattaaa gaaagccttt agatttatcc aatgtttact 2796
actgggattg cttaaagtga ggcccctcca acaccagggg gttaattcct gtgattgtga 2856
aaggggctac ttccaaggca tcttcatgca ggcagcccct tgggagggca cctgagagct 2916
ggtagagtct gaaattaggg atgtgagcct cgtggttact gagtaaggta aaattgcatc 2976
caccattgtt tgtgatacct tagggaattg cttggacctg gtgacaaggg ctcctgttca 3036
atagtggtgt tggggagaga gagagcagtg attatagacc gagagagtag gagttgaggt 3096
gaggtgaagg aggtgctggg ggtgagaatg tcgcctttcc ccctgggttt tggatcacta 3156
attcaaggct cttctggatg tttctctggg ttggggctgg agttcaatga ggtttatttt 3216
tagctggccc acccagatac actcagccag aatacctaga tttagtaccc aaactcttct 3276
tagtctgaaa tctgctggat ttctggccta agggagaggc tcccatcctt cgttccccag 3336
ccagcctagg acttcgaatg tggagcctga agatctaaga tcctaacatg tacattttat 3396
gtaaatatgt gcatatttgt acataaaatg atattctgtt tttaaataaa cagacaaaac 3456
ttgaaaaa                                                          3464

<210> 2
<211> 510
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (1)...(510)
<223> 191P4D12

<400> 2
Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Ala Ser Phe Thr Gly Arg Cys Pro Ala Gly
            20                  25                  30          
Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala
        35                  40                  45              
Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly Gln
    50                  55                  60                  
Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu Ala
65                  70                  75                  80  
Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Gly
                85                  90                  95      
Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser Val
            100                 105                 110         
Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg
        115                 120                 125             
Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu Arg
    130                 135                 140                 
Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu
145                 150                 155                 160 
Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser
                165                 170                 175     
Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser
            180                 185                 190         
Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe
        195                 200                 205             
His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val
    210                 215                 220                 
Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu
225                 230                 235                 240 
His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln
                245                 250                 255     
Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser
            260                 265                 270         
Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro
        275                 280                 285             
Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro
    290                 295                 300                 
Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu
305                 310                 315                 320 
Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln
                325                 330                 335     
Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val
            340                 345                 350         
Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val
        355                 360                 365             
Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln
    370                 375                 380                 
Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg
385                 390                 395                 400 
Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val
                405                 410                 415     
Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser
            420                 425                 430         
Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu
        435                 440                 445             
Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly
    450                 455                 460                 
Ser Gly Arg Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln
465                 470                 475                 480 
Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro
                485                 490                 495     
Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val
            500                 505                 510 


<210> 3
<211> 1432
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (32)...(1432)

<220> 
<221> misc_feature   
<222> (1)...(1432)
<223> Ha22-2(2,4)6.1 heavy chain

<400> 3
ggtgatcagc actgaacaca gaggactcac c atg gag ttg ggg ctg tgc tgg    52
                                   Met Glu Leu Gly Leu Cys Trp
                                    1               5
 
gtt ttc ctt gtt gct att tta gaa ggt gtc cag tgt gag gtg cag ctg   100
Val Phe Leu Val Ala Ile Leu Glu Gly Val Gln Cys Glu Val Gln Leu
         10                  15                  20
 
gtg gag tct ggg gga ggc ttg gta cag cct ggg ggg tcc ctg aga ctc   148
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu
     25                  30                  35
 
tcc tgt gca gcc tct gga ttc acc ttc agt agc tat aac atg aac tgg   196
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asn Met Asn Trp
 40                  45                  50                  55
 
gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtt tca tac att agt   244
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser
                 60                  65                  70
 
agt agt agt agt acc ata tac tac gca gac tct gtg aag ggc cga ttc   292
Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe
             75                  80                  85
 
acc atc tcc aga gac aat gcc aag aac tca ctg tct ctg caa atg aac   340
Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser Leu Gln Met Asn
         90                  95                 100
 
agc ctg aga gac gag gac acg gct gtg tat tac tgt gcg aga gca tac   388
Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Tyr
    105                 110                 115
 
tac tac ggt atg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc   436
Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
120                 125                 130                 135
 
tca gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc   484
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
                140                 145                 150
 
aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac   532
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
            155                 160                 165
 
tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc   580
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
        170                 175                 180
 
agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac   628
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
    185                 190                 195
 
tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag   676
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
200                 205                 210                 215
 
acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac   724
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
                220                 225                 230
 
aag aga gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg   772
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
            235                 240                 245
 
tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc   820
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
        250                 255                 260
 
cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca   868
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
    265                 270                 275
 
tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac   916
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
280                 285                 290                 295
 
tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg   964
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                300                 305                 310
 
gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc   1012
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
            315                 320                 325
 
ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc   1060
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
        330                 335                 340
 
aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa   1108
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
    345                 350                 355
 
ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag   1156
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
360                 365                 370                 375
 
gag atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc   1204
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                380                 385                 390
 
tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag   1252
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
            395                 400                 405
 
aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc   1300
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
        410                 415                 420
 
ttc ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg   1348
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
    425                 430                 435
 
aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac   1396
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
440                 445                 450                 455
 
acg cag aag agc ctc tcc ctg tcc ccg ggt aaa tga                   1432
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys  
                460                 465
 

<210> 4
<211> 466
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature           
<222> (1)...(466)
<223> Ha22-2(2,4)6.1 heavy chain

<400> 4
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly
 1               5                  10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
        35                  40                  45              
Ser Ser Tyr Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
                85                  90                  95      
Ser Leu Ser Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Ala Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
    130                 135                 140                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
145                 150                 155                 160 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
                165                 170                 175     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
            180                 185                 190         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
        195                 200                 205             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
    210                 215                 220                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp
225                 230                 235                 240 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
            260                 265                 270         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
        275                 280                 285             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
            340                 345                 350         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
        355                 360                 365             
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
385                 390                 395                 400 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
            420                 425                 430         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
    450                 455                 460                 
Gly Lys
465     


<210> 5
<211> 735
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (25)...(735)

<220> 
<221> misc_feature   
<222> (1)...(735)
<223> Ha22-2(2,4)6.1 light chain

<400> 5
agtcagaccc agtcaggaca cagc atg gac atg agg gtc ccc gct cag ctc    51
                           Met Asp Met Arg Val Pro Ala Gln Leu
                            1               5
 
ctg ggg ctc ctg ctg ctc tgg ttc cca ggt tcc aga tgc gac atc cag   99
Leu Gly Leu Leu Leu Leu Trp Phe Pro Gly Ser Arg Cys Asp Ile Gln
 10                  15                  20                  25
 
atg acc cag tct cca tct tcc gtg tct gca tct gtt gga gac aga gtc   147
Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val
                 30                  35                  40
 
acc atc act tgt cgg gcg agt cag ggt att agc ggc tgg tta gcc tgg   195
Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Gly Trp Leu Ala Trp
             45                  50                  55
 
tat cag cag aaa cca ggg aaa gcc cct aag ttc ctg atc tat gct gca   243
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile Tyr Ala Ala
         60                  65                  70
 
tcc act ttg caa agt ggg gtc cca tca agg ttc agc ggc agt gga tct   291
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
     75                  80                  85
 
ggg aca gat ttc act ctc acc atc agc agc ctg cag cct gaa gat ttt   339
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe
 90                  95                 100                 105
 
gca act tac tat tgt caa cag gct aac agt ttc cct ccc act ttc ggc   387
Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Pro Thr Phe Gly
                110                 115                 120
 
gga ggg acc aag gtg gag atc aaa cga act gtg gct gca cca tct gtc   435
Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val
            125                 130                 135
 
ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga act gcc tct   483
Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
        140                 145                 150
 
gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc aaa gta cag   531
Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln
    155                 160                 165
 
tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag gag agt gtc   579
Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val
170                 175                 180                 185
 
aca gag cag gac agc aag gac agc acc tac agc ctc agc agc acc ctg   627
Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu
                190                 195                 200
 
acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac gcc tgc gaa   675
Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu
            205                 210                 215
 
gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc ttc aac agg   723
Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg
        220                 225                 230
 
gga gag tgt tag                                                   735
Gly Glu Cys  
    235
 

<210> 6
<211> 236
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature        
<222> (1)...(236)
<223> Ha22-2(2,4)6.1 light chain

<400> 6
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Phe Pro Gly Ser Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Gly Ile Ser Gly Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Phe Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
            100                 105                 110         
Ala Asn Ser Phe Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235     


<210> 7
<211> 466
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature 
<222> (1)...(466)
<223> Ha22-2(2,4)6.1 heavy chain

<400> 7
Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly
 1               5                  10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
        35                  40                  45              
Ser Ser Tyr Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
                85                  90                  95      
Ser Leu Ser Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Ala Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
    130                 135                 140                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
145                 150                 155                 160 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
                165                 170                 175     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
            180                 185                 190         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
        195                 200                 205             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
    210                 215                 220                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp
225                 230                 235                 240 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
            260                 265                 270         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
        275                 280                 285             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
            340                 345                 350         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
        355                 360                 365             
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
385                 390                 395                 400 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
            420                 425                 430         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
    450                 455                 460                 
Gly Lys
465     


<210> 8
<211> 236
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature  
<222> (1)...(236)
<223> Ha22-2(2,4)6.1 light chain

<400> 8
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Phe Pro Gly Ser Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Gly Ile Ser Gly Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Phe Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
            100                 105                 110         
Ala Asn Ser Phe Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235     


<210> 9
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<223> CDR1 of heavy chain

<400> 9

Ser Tyr Asn Met Asn 
1               5   


<210> 10
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<223> CDR2 of heavy chain

<400> 10

Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    


<210> 11
<211> 8
<212> PRT
<213> Homo sapiens

<220>
<223> CDR3 of heavy chain

<400> 11

Ala Tyr Tyr Tyr Gly Met Asp Val 
1               5               


<210> 12
<211> 11
<212> PRT
<213> Homo sapiens

<220>
<223> CDR1 of light chain

<400> 12

Arg Ala Ser Gln Gly Ile Ser Gly Trp Leu Ala 
1               5                   10      


<210> 13
<211> 7
<212> PRT
<213> Homo sapiens

<220>
<223> CDR2 of light chain

<400> 13

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210> 14
<211> 9
<212> PRT
<213> Homo sapiens

<220>
<223> CDR3 of light chain

<400> 14

Gln Gln Ala Asn Ser Phe Pro Pro Thr 
1               5                   


<210> 15
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> linker

<400> 15

Gly Phe Leu Gly 
1      


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 according to IMGT

<400>  16

Gly Phe Thr Phe Ser Ser Tyr Asn 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 according to IMGT

<400>  17

Ile Ser Ser Ser Ser Ser Thr Ile 
1               5               


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 according to IMGT

<400>  18

Ala Arg Ala Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10  


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 according to IMGT

<400>  19

Gln Gly Ile Ser Gly Trp 
1               5       


<210>  20
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 according to IMGT

<400>  20

Ala Ala Ser 
1           


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 according to IMGT

<400>  21

Gln Gln Ala Asn Ser Phe Pro Pro Thr 
1               5                   


<210>  22
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region (VH), the 20th amino acid (glutamic 
       acid) to the 136th amino acid (serine) of SEQ ID NO:7

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  23
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region (VL), the 23rd amino acid (aspartic 
       acid) to the 130th amino acid (arginine) of SEQ ID NO:8

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             

    