<110>    Seoul National University R&DB Foundation
         ABION Inc.

<120>    Anti c-Met agonist antibody and uses thereof

<130>    OP19-0207/PCT

<150>    KR 10-2018-0157325
<151>    2018-12-07

<160>    8

<170>    KoPatentIn 3.0

<210>    1
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-CDR1 of c-Met A8


<400>    1
Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn Asn Val Tyr
  1               5                  10            


<210>    2
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-CDR2 of c-Met A8


<400>    2
Ala Asn Ser His Arg Pro Ser
  1               5        


<210>    3
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-CDR3 of c-Met A8


<400>    3
Gly Ser Trp Asp Tyr Ser Leu Asn Gly
  1               5                


<210>    4
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-CDR1 of c-Met A8


<400>    4
Asp Tyr Tyr Met Ser
  1               5


<210>    5
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-CDR2 of c-Met A8


<400>    5
Ala Ile Ser His Asp Asp Ser Ser Ile Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    6
<211>    18
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-CDR3 of c-Met A8


<400>    6
Asp Leu Leu Gln Cys Asn Ser Glu Gln Cys Tyr Ser Asp Asn Gly Met
  1               5                  10                  15 

Asp Val
       


<210>    7
<211>    1408
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Homo sapiens c-Met Protein


<400>    7
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
  1               5                  10                  15 

Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
             20                  25                  30 

Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
         35                  40                  45 

Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
     50                  55                  60 

Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
 65                  70                  75                  80 

Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                 85                  90                  95 

Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110 

Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125 

Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140 

Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 

Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175 

Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190 

Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205 

His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220 

Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 

Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255 

Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270 

Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285 

His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300 

Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 

Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335 

Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350 

Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365 

Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380 

Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 

Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415 

Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430 

Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445 

Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460 

Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 

Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495 

Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510 

Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525 

Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540 

Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 

Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575 

Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590 

Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605 

Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620 

Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 

Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655 

Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670 

Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685 

His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700 

Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720 

Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735 

Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750 

Phe Ile Ser Thr Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu
        755                 760                 765 

Phe Cys Phe Ala Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn
    770                 775                 780 

Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala
785                 790                 795                 800 

Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile
                805                 810                 815 

Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro
            820                 825                 830 

Leu Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr
        835                 840                 845 

Phe Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys
    850                 855                 860 

Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly
865                 870                 875                 880 

Asn Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly
                885                 890                 895 

Asn Lys Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys
            900                 905                 910 

Thr Val Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu
        915                 920                 925 

Trp Lys Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln
    930                 935                 940 

Pro Asp Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser
945                 950                 955                 960 

Thr Ala Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg
                965                 970                 975 

Lys Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg
            980                 985                 990 

Val His Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser
        995                1000                1005 

Pro Thr Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr
   1010                1015                1020 

Phe Pro Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg
1025               1030                1035                1040 

Gln Val Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly
               1045                1050                1055 

Asp Ser Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp
           1060                1065                1070 

Leu Ser Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val
       1075                1080                1085 

Ile Gly Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg
   1090                1095                1100 

Gly His Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp Asn Asp Gly
1105               1110                1115                1120 

Lys Lys Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile
               1125                1130                1135 

Gly Glu Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe
           1140                1145                1150 

Ser His Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu
       1155                1160                1165 

Gly Ser Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg
   1170                1175                1180 

Asn Phe Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile
1185               1190                1195                1200 

Gly Phe Gly Leu Gln Val Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys
               1205                1210                1215 

Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu
           1220                1225                1230 

Lys Phe Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr
       1235                1240                1245 

Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro
   1250                1255                1260 

Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr
1265               1270                1275                1280 

Lys Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Leu Met Thr
               1285                1290                1295 

Arg Gly Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Val
           1300                1305                1310 

Tyr Leu Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp
       1315                1320                1325 

Pro Leu Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met
   1330                1335                1340 

Arg Pro Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala Ile Phe Ser
1345               1350                1355                1360 

Thr Phe Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn
               1365                1370                1375 

Val Lys Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn
           1380                1385                1390 

Ala Asp Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser
       1395                1400                1405 




<210>    8
<211>    6710
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Homo sapiens c-Met mRNA


<400>    8
gcaggtgacc cggaggccct cgccgcccgc ggcgccccga gcgctttgtg agcagatgcg         60

gagccgagtg gagggcgcga gccagatgcg gggcgacagc tgacttgctg agaggaggcg        120

gggaggcgcg gagcgcgcgt gtggtccttg cgccgctgac ttctccactg gttcctgggc        180

accgaaagat aaacctctca taatgaaggc ccccgctgtg cttgcacctg gcatcctcgt        240

gctcctgttt accttggtgc agaggagcaa tggggagtgt aaagaggcac tagcaaagtc        300

cgagatgaat gtgaatatga agtatcagct tcccaacttc accgcggaaa cacccatcca        360

gaatgtcatt ctacatgagc atcacatttt ccttggtgcc actaactaca tttatgtttt        420

aaatgaggaa gaccttcaga aggttgctga gtacaagact gggcctgtgc tggaacaccc        480

agattgtttc ccatgtcagg actgcagcag caaagccaat ttatcaggag gtgtttggaa        540

agataacatc aacatggctc tagttgtcga cacctactat gatgatcaac tcattagctg        600

tggcagcgtc aacagaggga cctgccagcg acatgtcttt ccccacaatc atactgctga        660

catacagtcg gaggttcact gcatattctc cccacagata gaagagccca gccagtgtcc        720

tgactgtgtg gtgagcgccc tgggagccaa agtcctttca tctgtaaagg accggttcat        780

caacttcttt gtaggcaata ccataaattc ttcttatttc ccagatcatc cattgcattc        840

gatatcagtg agaaggctaa aggaaacgaa agatggtttt atgtttttga cggaccagtc        900

ctacattgat gttttacctg agttcagaga ttcttacccc attaagtatg tccatgcctt        960

tgaaagcaac aattttattt acttcttgac ggtccaaagg gaaactctag atgctcagac       1020

ttttcacaca agaataatca ggttctgttc cataaactct ggattgcatt cctacatgga       1080

aatgcctctg gagtgtattc tcacagaaaa gagaaaaaag agatccacaa agaaggaagt       1140

gtttaatata cttcaggctg cgtatgtcag caagcctggg gcccagcttg ctagacaaat       1200

aggagccagc ctgaatgatg acattctttt cggggtgttc gcacaaagca agccagattc       1260

tgccgaacca atggatcgat ctgccatgtg tgcattccct atcaaatatg tcaacgactt       1320

cttcaacaag atcgtcaaca aaaacaatgt gagatgtctc cagcattttt acggacccaa       1380

tcatgagcac tgctttaata ggacacttct gagaaattca tcaggctgtg aagcgcgccg       1440

tgatgaatat cgaacagagt ttaccacagc tttgcagcgc gttgacttat tcatgggtca       1500

attcagcgaa gtcctcttaa catctatatc caccttcatt aaaggagacc tcaccatagc       1560

taatcttggg acatcagagg gtcgcttcat gcaggttgtg gtttctcgat caggaccatc       1620

aacccctcat gtgaattttc tcctggactc ccatccagtg tctccagaag tgattgtgga       1680

gcatacatta aaccaaaatg gctacacact ggttatcact gggaagaaga tcacgaagat       1740

cccattgaat ggcttgggct gcagacattt ccagtcctgc agtcaatgcc tctctgcccc       1800

accctttgtt cagtgtggct ggtgccacga caaatgtgtg cgatcggagg aatgcctgag       1860

cgggacatgg actcaacaga tctgtctgcc tgcaatctac aaggttttcc caaatagtgc       1920

accccttgaa ggagggacaa ggctgaccat atgtggctgg gactttggat ttcggaggaa       1980

taataaattt gatttaaaga aaactagagt tctccttgga aatgagagct gcaccttgac       2040

tttaagtgag agcacgatga atacattgaa atgcacagtt ggtcctgcca tgaataagca       2100

tttcaatatg tccataatta tttcaaatgg ccacgggaca acacaataca gtacattctc       2160

ctatgtggat cctgtaataa caagtatttc gccgaaatac ggtcctatgg ctggtggcac       2220

tttacttact ttaactggaa attacctaaa cagtgggaat tctagacaca tttcaattgg       2280

tggaaaaaca tgtactttaa aaagtgtgtc aaacagtatt cttgaatgtt ataccccagc       2340

ccaaaccatt tcaactgagt ttgctgttaa attgaaaatt gacttagcca accgagagac       2400

aagcatcttc agttaccgtg aagatcccat tgtctatgaa attcatccaa ccaaatcttt       2460

tattagtact tggtggaaag aacctctcaa cattgtcagt tttctatttt gctttgccag       2520

tggtgggagc acaataacag gtgttgggaa aaacctgaat tcagttagtg tcccgagaat       2580

ggtcataaat gtgcatgaag caggaaggaa ctttacagtg gcatgtcaac atcgctctaa       2640

ttcagagata atctgttgta ccactccttc cctgcaacag ctgaatctgc aactccccct       2700

gaaaaccaaa gcctttttca tgttagatgg gatcctttcc aaatactttg atctcattta       2760

tgtacataat cctgtgttta agccttttga aaagccagtg atgatctcaa tgggcaatga       2820

aaatgtactg gaaattaagg gaaatgatat tgaccctgaa gcagttaaag gtgaagtgtt       2880

aaaagttgga aataagagct gtgagaatat acacttacat tctgaagccg ttttatgcac       2940

ggtccccaat gacctgctga aattgaacag cgagctaaat atagagtgga agcaagcaat       3000

ttcttcaacc gtccttggaa aagtaatagt tcaaccagat cagaatttca caggattgat       3060

tgctggtgtt gtctcaatat caacagcact gttattacta cttgggtttt tcctgtggct       3120

gaaaaagaga aagcaaatta aagatctggg cagtgaatta gttcgctacg atgcaagagt       3180

acacactcct catttggata ggcttgtaag tgcccgaagt gtaagcccaa ctacagaaat       3240

ggtttcaaat gaatctgtag actaccgagc tacttttcca gaagatcagt ttcctaattc       3300

atctcagaac ggttcatgcc gacaagtgca gtatcctctg acagacatgt cccccatcct       3360

aactagtggg gactctgata tatccagtcc attactgcaa aatactgtcc acattgacct       3420

cagtgctcta aatccagagc tggtccaggc agtgcagcat gtagtgattg ggcccagtag       3480

cctgattgtg catttcaatg aagtcatagg aagagggcat tttggttgtg tatatcatgg       3540

gactttgttg gacaatgatg gcaagaaaat tcactgtgct gtgaaatcct tgaacagaat       3600

cactgacata ggagaagttt cccaatttct gaccgaggga atcatcatga aagattttag       3660

tcatcccaat gtcctctcgc tcctgggaat ctgcctgcga agtgaagggt ctccgctggt       3720

ggtcctacca tacatgaaac atggagatct tcgaaatttc attcgaaatg agactcataa       3780

tccaactgta aaagatctta ttggctttgg tcttcaagta gccaaaggca tgaaatatct       3840

tgcaagcaaa aagtttgtcc acagagactt ggctgcaaga aactgtatgc tggatgaaaa       3900

attcacagtc aaggttgctg attttggtct tgccagagac atgtatgata aagaatacta       3960

tagtgtacac aacaaaacag gtgcaaagct gccagtgaag tggatggctt tggaaagtct       4020

gcaaactcaa aagtttacca ccaagtcaga tgtgtggtcc tttggcgtgc tcctctggga       4080

gctgatgaca agaggagccc caccttatcc tgacgtaaac acctttgata taactgttta       4140

cttgttgcaa gggagaagac tcctacaacc cgaatactgc ccagacccct tatatgaagt       4200

aatgctaaaa tgctggcacc ctaaagccga aatgcgccca tccttttctg aactggtgtc       4260

ccggatatca gcgatcttct ctactttcat tggggagcac tatgtccatg tgaacgctac       4320

ttatgtgaac gtaaaatgtg tcgctccgta tccttctctg ttgtcatcag aagataacgc       4380

tgatgatgag gtggacacac gaccagcctc cttctgggag acatcatagt gctagtacta       4440

tgtcaaagca acagtccaca ctttgtccaa tggttttttc actgcctgac ctttaaaagg       4500

ccatcgatat tctttgctct tgccaaaatt gcactattat aggacttgta ttgttattta       4560

aattactgga ttctaaggaa tttcttatct gacagagcat cagaaccaga ggcttggtcc       4620

cacaggccac ggaccaatgg cctgcagccg tgacaacact cctgtcatat tggagtccaa       4680

aacttgaatt ctgggttgaa ttttttaaaa atcaggtacc acttgatttc atatgggaaa       4740

ttgaagcagg aaatattgag ggcttcttga tcacagaaaa ctcagaagag atagtaatgc       4800

tcaggacagg agcggcagcc ccagaacagg ccactcattt agaattctag tgtttcaaaa       4860

cacttttgtg tgttgtatgg tcaataacat ttttcattac tgatggtgtc attcacccat       4920

taggtaaaca ttccctttta aatgtttgtt tgttttttga gacaggatct cactctgttg       4980

ccagggctgt agtgcagtgg tgtgatcata gctcactgca acctccacct cccaggctca       5040

agcctcccga atagctggga ctacaggcgc acaccaccat ccccggctaa tttttgtatt       5100

ttttgtagag acggggtttt gccatgttgc caaggctggt ttcaaactcc tggactcaag       5160

aaatccaccc acctcagcct cccaaagtgc taggattaca ggcatgagcc actgcgccca       5220

gcccttataa atttttgtat agacattcct ttggttggaa gaatatttat aggcaataca       5280

gtcaaagttt caaaatagca tcacacaaaa catgtttata aatgaacagg atgtaatgta       5340

catagatgac attaagaaaa tttgtatgaa ataatttagt catcatgaaa tatttagttg       5400

tcatataaaa acccactgtt tgagaatgat gctactctga tctaatgaat gtgaacatgt       5460

agatgttttg tgtgtatttt tttaaatgaa aactcaaaat aagacaagta atttgttgat       5520

aaatattttt aaagataact cagcatgttt gtaaagcagg atacatttta ctaaaaggtt       5580

cattggttcc aatcacagct cataggtaga gcaaagaaag ggtggatgga ttgaaaagat       5640

tagcctctgt ctcggtggca ggttcccacc tcgcaagcaa ttggaaacaa aacttttggg       5700

gagttttatt ttgcattagg gtgtgtttta tgttaagcaa aacatacttt agaaacaaat       5760

gaaaaaggca attgaaaatc ccagctattt cacctagatg gaatagccac cctgagcaga       5820

actttgtgat gcttcattct gtggaatttt gtgcttgcta ctgtatagtg catgtggtgt       5880

aggttactct aactggtttt gtcgacgtaa acatttaaag tgttatattt tttataaaaa       5940

tgtttatttt taatgatatg agaaaaattt tgttaggcca caaaaacact gcactgtgaa       6000

cattttagaa aaggtatgtc agactgggat taatgacagc atgattttca atgactgtaa       6060

attgcgataa ggaaatgtac tgattgccaa tacaccccac cctcattaca tcatcaggac       6120

ttgaagccaa gggttaaccc agcaagctac aaagagggtg tgtcacactg aaactcaata       6180

gttgagtttg gctgttgttg caggaaaatg attataacta aaagctctct gatagtgcag       6240

agacttacca gaagacacaa ggaattgtac tgaagagcta ttacaatcca aatattgccg       6300

tttcataaat gtaataagta atactaattc acagagtatt gtaaatggtg gatgacaaaa       6360

gaaaatctgc tctgtggaaa gaaagaactg tctctaccag ggtcaagagc atgaacgcat       6420

caatagaaag aactcgggga aacatcccat caacaggact acacacttgt atatacattc       6480

ttgagaacac tgcaatgtga aaatcacgtt tgctatttat aaacttgtcc ttagattaat       6540

gtgtctggac agattgtggg agtaagtgat tcttctaaga attagatact tgtcactgcc       6600

tatacctgca gctgaactga atggtacttc gtatgttaat agttgttctg ataaatcatg       6660

caattaaagt aaagtgatgc aacatcttgt aaaaaaaaaa aaaaaaaaaa                  6710
