                         SEQUENCE LISTING

<110>  LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC
 
<120>  MODULATION OF NADPH GENERATION BY RECOMBINANT YEAST HOST CELL 
       DURING FERMENTATION

<130>  55729550-35PCT

<150>  62/776,910
<151>  2018-12-07

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  1428
<212>  DNA
<213>  Streptococcus mutans

<400>  1
atgacaaaac aatataaaaa ttatgtcaat ggcgagtgga agctttcaga aaatgaaatt       60

aaaatctacg aaccggccag tggagctgaa ttgggttcag ttccagcaat gagtactgaa      120

gaagtagatt atgtttatgc ttcagccaag aaagctcaac cagcttggcg atcactttca      180

tacatagaac gtgctgccta ccttcataag gtagcagata ttttgatgcg tgataaagaa      240

aaaataggtg ctgttctttc caaagaggtt gctaaaggtt ataaatcagc agtcagcgaa      300

gttgttcgta ctgcagaaat cattaattat gcagctgaag aaggccttcg tatggaaggt      360

gaagtccttg aaggcggcag ttttgaagca gccagcaaga aaaaaattgc cgttgttcgt      420

cgtgaaccag taggtcttgt attagctatt tcaccattta actaccctgt taacttggca      480

ggttcgaaaa ttgcaccggc tcttattgcg ggaaatgtta ttgcttttaa accaccgacg      540

caaggatcaa tctcagggct cttacttgct gaagcatttg ctgaagctgg acttcctgca      600

ggtgtcttta ataccattac aggtcgtggt tctgaaattg gagactatat tgtagaacat      660

caagccgtta actttatcaa tttcactggt tcaacaggaa ttggggaacg tattggcaaa      720

atggctggta tgcgtccgat tatgcttgaa ctcggtggaa aagattcagc catcgttctt      780

gaagatgcag accttgaatt gactgctaaa aatattattg caggtgcttt tggttattca      840

ggtcaacgct gtacagcagt taaacgtgtt cttgtgatgg aaagtgttgc tgatgaactg      900

gtcgaaaaaa tccgtgaaaa agttcttgca ttaacaattg gtaatccaga agacgatgca      960

gatattacac cgttgattga tacaaaatca gctgattatg tagaaggtct tattaatgat     1020

gccaatgata aaggagccgc tgcccttact gaaatcaaac gtgaaggtaa tcttatctgt     1080

ccaatcctct ttgataaggt aacgacagat atgcgtcttg cttgggaaga accatttggt     1140

cctgttcttc cgatcattcg tgtgacatct gtagaagaag ccattgaaat ttctaacaaa     1200

tcggaatatg gacttcaggc ttctatcttt acaaatgatt tcccacgcgc ttttggtatt     1260

gctgagcagc ttgaagttgg tacagttcat atcaataata agacacagcg cggtacggac     1320

aacttcccat tcttaggggc taaaaaatca ggtgcaggta ttcaaggggt aaaatattct     1380

attgaagcta tgacaactgt taaatccgtc gtatttgata tcaaataa                  1428


<210>  2
<211>  475
<212>  PRT
<213>  Streptococcus mutans

<400>  2

Met Thr Lys Gln Tyr Lys Asn Tyr Val Asn Gly Glu Trp Lys Leu Ser 
1               5                   10                  15      


Glu Asn Glu Ile Lys Ile Tyr Glu Pro Ala Ser Gly Ala Glu Leu Gly 
            20                  25                  30          


Ser Val Pro Ala Met Ser Thr Glu Glu Val Asp Tyr Val Tyr Ala Ser 
        35                  40                  45              


Ala Lys Lys Ala Gln Pro Ala Trp Arg Ser Leu Ser Tyr Ile Glu Arg 
    50                  55                  60                  


Ala Ala Tyr Leu His Lys Val Ala Asp Ile Leu Met Arg Asp Lys Glu 
65                  70                  75                  80  


Lys Ile Gly Ala Val Leu Ser Lys Glu Val Ala Lys Gly Tyr Lys Ser 
                85                  90                  95      


Ala Val Ser Glu Val Val Arg Thr Ala Glu Ile Ile Asn Tyr Ala Ala 
            100                 105                 110         


Glu Glu Gly Leu Arg Met Glu Gly Glu Val Leu Glu Gly Gly Ser Phe 
        115                 120                 125             


Glu Ala Ala Ser Lys Lys Lys Ile Ala Val Val Arg Arg Glu Pro Val 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Val Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Ile Ala Gly Asn Val Ile Ala Phe 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Leu Leu Ala Glu Ala 
            180                 185                 190         


Phe Ala Glu Ala Gly Leu Pro Ala Gly Val Phe Asn Thr Ile Thr Gly 
        195                 200                 205             


Arg Gly Ser Glu Ile Gly Asp Tyr Ile Val Glu His Gln Ala Val Asn 
    210                 215                 220                 


Phe Leu Asn Phe Thr Gly Ser Thr Gly Ile Gly Glu Arg Ile Gly Lys 
225                 230                 235                 240 


Met Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ser 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Glu Leu Thr Ala Lys Asn Ile 
            260                 265                 270         


Ile Ala Gly Ala Phe Gly Tyr Ser Gly Gln Arg Cys Thr Ala Val Lys 
        275                 280                 285             


Arg Val Leu Val Met Glu Ser Val Ala Asp Glu Leu Val Glu Lys Ile 
    290                 295                 300                 


Arg Glu Lys Val Leu Ala Leu Thr Ile Gly Asn Pro Glu Asp Asp Ala 
305                 310                 315                 320 


Asp Ile Thr Pro Leu Ile Asp Thr Lys Ser Ala Asp Tyr Val Glu Gly 
                325                 330                 335     


Leu Ile Asn Asp Ala Asn Asp Lys Gly Ala Ala Ala Leu Thr Glu Ile 
            340                 345                 350         


Lys Arg Glu Gly Asn Leu Ile Cys Pro Ile Leu Phe Asp Lys Val Thr 
        355                 360                 365             


Ile Asp Met Arg Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Ile Ile Arg Val Thr Ser Val Glu Glu Ala Ile Glu Ile Ser Asn Lys 
385                 390                 395                 400 


Ser Glu Tyr Gly Leu Gln Ala Ser Ile Phe Thr Asn Asp Phe Pro Arg 
                405                 410                 415     


Ala Phe Gly Ile Ala Glu Gln Leu Glu Val Gly Thr Val His Ile Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Thr Asp Asn Phe Pro Phe Leu Gly Ala Lys 
        435                 440                 445             


Lys Ser Gly Ala Gly Ile Gln Gly Val Lys Tyr Ser Ile Glu Ala Met 
    450                 455                 460                 


Thr Thr Val Lys Ser Val Val Phe Asp Ile Lys 
465                 470                 475 


<210>  3
<211>  504
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Ser Glu Gly Pro Val Lys Phe Glu Lys Asn Thr Val Ile Ser Val 
1               5                   10                  15      


Phe Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Thr Phe Pro Ala Leu 
            20                  25                  30          


Phe Gly Leu Phe Arg Glu Gly Tyr Leu Asp Pro Ser Thr Lys Ile Phe 
        35                  40                  45              


Gly Tyr Ala Arg Ser Lys Leu Ser Met Glu Asp Leu Lys Ser Arg Val 
    50                  55                  60                  


Leu Pro His Leu Lys Lys Pro His Gly Glu Ala Asp Asp Ser Lys Val 
65                  70                  75                  80  


Glu Gln Phe Phe Lys Met Val Ser Tyr Ile Ser Gly Asn Tyr Asp Thr 
                85                  90                  95      


Asp Glu Gly Phe Asp Glu Leu Arg Thr Gln Ile Glu Lys Phe Glu Lys 
            100                 105                 110         


Ser Ala Asn Val Asp Val Pro His Arg Leu Phe Tyr Leu Ala Leu Pro 
        115                 120                 125             


Pro Ser Val Phe Leu Thr Val Ala Lys Gln Ile Lys Ser Arg Val Tyr 
    130                 135                 140                 


Ala Glu Asn Gly Ile Thr Arg Val Ile Val Glu Lys Pro Phe Gly His 
145                 150                 155                 160 


Asp Leu Ala Ser Ala Arg Glu Leu Gln Lys Asn Leu Gly Pro Leu Phe 
                165                 170                 175     


Lys Glu Glu Glu Leu Tyr Arg Ile Asp His Tyr Leu Gly Lys Glu Leu 
            180                 185                 190         


Val Lys Asn Leu Leu Val Leu Arg Phe Gly Asn Gln Phe Leu Asn Ala 
        195                 200                 205             


Ser Trp Asn Arg Asp Asn Ile Gln Ser Val Gln Ile Ser Phe Lys Glu 
    210                 215                 220                 


Arg Phe Gly Thr Glu Gly Arg Gly Gly Tyr Phe Asp Ser Ile Gly Ile 
225                 230                 235                 240 


Ile Arg Asp Val Met Gln Asn His Leu Leu Gln Ile Met Thr Leu Leu 
                245                 250                 255     


Thr Met Glu Arg Pro Val Ser Phe Asp Pro Glu Ser Ile Arg Asp Glu 
            260                 265                 270         


Lys Val Lys Val Leu Lys Ala Val Ala Pro Ile Asp Thr Asp Asp Val 
        275                 280                 285             


Leu Leu Gly Gln Tyr Gly Lys Ser Glu Asp Gly Ser Lys Pro Ala Tyr 
    290                 295                 300                 


Val Asp Asp Asp Thr Val Asp Lys Asp Ser Lys Cys Val Thr Phe Ala 
305                 310                 315                 320 


Ala Met Thr Phe Asn Ile Glu Asn Glu Arg Trp Glu Gly Val Pro Ile 
                325                 330                 335     


Met Met Arg Ala Gly Lys Ala Leu Asn Glu Ser Lys Val Glu Ile Arg 
            340                 345                 350         


Leu Gln Tyr Lys Ala Val Ala Ser Gly Val Phe Lys Asp Ile Pro Asn 
        355                 360                 365             


Asn Glu Leu Val Ile Arg Val Gln Pro Asp Ala Ala Val Tyr Leu Lys 
    370                 375                 380                 


Phe Asn Ala Lys Thr Pro Gly Leu Ser Asn Ala Thr Gln Val Thr Asp 
385                 390                 395                 400 


Leu Asn Leu Thr Tyr Ala Ser Arg Tyr Gln Asp Phe Trp Ile Pro Glu 
                405                 410                 415     


Ala Tyr Glu Val Leu Ile Arg Asp Ala Leu Leu Gly Asp His Ser Asn 
            420                 425                 430         


Phe Val Arg Asp Asp Glu Leu Asp Ile Ser Trp Gly Ile Phe Thr Pro 
        435                 440                 445             


Leu Leu Lys His Ile Glu Arg Pro Asp Gly Pro Thr Pro Glu Ile Tyr 
    450                 455                 460                 


Pro Tyr Gly Ser Arg Gly Pro Lys Gly Leu Lys Glu Tyr Met Gln Lys 
465                 470                 475                 480 


His Lys Tyr Val Met Pro Glu Lys His Pro Tyr Ala Trp Pro Val Thr 
                485                 490                 495     


Lys Pro Glu Asp Thr Lys Asp Asn 
            500                 


<210>  4
<211>  489
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  4

Met Ser Ala Asp Phe Gly Leu Ile Gly Leu Ala Val Met Gly Gln Asn 
1               5                   10                  15      


Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Cys Ala Tyr Asn 
            20                  25                  30          


Arg Thr Gln Ser Lys Val Asp His Phe Leu Ala Asn Glu Ala Lys Gly 
        35                  40                  45              


Lys Ser Ile Ile Gly Ala Thr Ser Ile Glu Asp Phe Ile Ser Lys Leu 
    50                  55                  60                  


Lys Arg Pro Arg Lys Val Met Leu Leu Val Lys Ala Gly Ala Pro Val 
65                  70                  75                  80  


Asp Ala Leu Ile Asn Gln Ile Val Pro Leu Leu Glu Lys Gly Asp Ile 
                85                  90                  95      


Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Ser Asn Arg Arg Tyr 
            100                 105                 110         


Glu Glu Leu Lys Lys Lys Gly Ile Leu Phe Val Gly Ser Gly Val Ser 
        115                 120                 125             


Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ala Trp Pro His Ile Lys Asn Ile Phe Gln Ser Ile Ser 
145                 150                 155                 160 


Ala Lys Ser Asp Gly Glu Pro Cys Cys Glu Trp Val Gly Pro Ala Gly 
                165                 170                 175     


Ala Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu Tyr Gly Asp 
            180                 185                 190         


Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg Leu Gly Gly 
        195                 200                 205             


Phe Thr Asp Lys Glu Ile Ser Asp Val Phe Ala Lys Trp Asn Asn Gly 
    210                 215                 220                 


Val Leu Asp Ser Phe Leu Val Glu Ile Thr Arg Asp Ile Leu Lys Phe 
225                 230                 235                 240 


Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met Asp Thr Ala 
                245                 250                 255     


Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala Leu Asp Leu 
            260                 265                 270         


Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Arg Cys Leu 
        275                 280                 285             


Ser Ala Leu Lys Asn Glu Arg Ile Arg Ala Ser Lys Val Leu Pro Gly 
    290                 295                 300                 


Pro Glu Val Pro Lys Asp Ala Val Lys Asp Arg Glu Gln Phe Val Asp 
305                 310                 315                 320 


Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala Gln 
                325                 330                 335     


Gly Phe Met Leu Ile Arg Glu Ala Ala Ala Thr Tyr Gly Trp Lys Leu 
            340                 345                 350         


Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile Arg 
        355                 360                 365             


Ser Val Phe Leu Gly Gln Ile Thr Lys Ala Tyr Arg Glu Glu Pro Asp 
    370                 375                 380                 


Leu Glu Asn Leu Leu Phe Asn Lys Phe Phe Ala Asp Ala Val Thr Lys 
385                 390                 395                 400 


Ala Gln Ser Gly Trp Arg Lys Ser Ile Ala Leu Ala Thr Thr Tyr Gly 
                405                 410                 415     


Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ser Phe Tyr Asp Gly Tyr 
            420                 425                 430         


Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln Arg Asp Tyr 
        435                 440                 445             


Phe Gly Ala His Thr Phe Arg Val Leu Pro Glu Cys Ala Ser Asp Asn 
    450                 455                 460                 


Leu Pro Val Asp Lys Asp Ile His Ile Asn Trp Thr Gly His Gly Gly 
465                 470                 475                 480 


Asn Val Ser Ser Ser Thr Tyr Gln Ala 
                485                 


<210>  5
<211>  492
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  5

Met Ser Lys Ala Val Gly Asp Leu Gly Leu Val Gly Leu Ala Val Met 
1               5                   10                  15      


Gly Gln Asn Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Val 
            20                  25                  30          


Ala Tyr Asn Arg Thr Gln Ser Lys Val Asp Arg Phe Leu Ala Asn Glu 
        35                  40                  45              


Ala Lys Gly Lys Ser Ile Ile Gly Ala Thr Ser Ile Glu Asp Leu Val 
    50                  55                  60                  


Ala Lys Leu Lys Lys Pro Arg Lys Ile Met Leu Leu Ile Lys Ala Gly 
65                  70                  75                  80  


Ala Pro Val Asp Thr Leu Ile Lys Glu Leu Val Pro His Leu Asp Lys 
                85                  90                  95      


Gly Asp Ile Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Thr Asn 
            100                 105                 110         


Arg Arg Tyr Glu Glu Leu Thr Lys Gln Gly Ile Leu Phe Val Gly Ser 
        115                 120                 125             


Gly Val Ser Gly Gly Glu Asp Gly Ala Arg Phe Gly Pro Ser Leu Met 
    130                 135                 140                 


Pro Gly Gly Ser Ala Glu Ala Trp Pro His Ile Lys Asn Ile Phe Gln 
145                 150                 155                 160 


Ser Ile Ala Ala Lys Ser Asn Gly Glu Pro Cys Cys Glu Trp Val Gly 
                165                 170                 175     


Pro Ala Gly Ser Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu 
            180                 185                 190         


Tyr Gly Asp Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg 
        195                 200                 205             


Ile Gly Arg Phe Thr Asp Lys Glu Ile Ser Glu Val Phe Asp Lys Trp 
    210                 215                 220                 


Asn Thr Gly Val Leu Asp Ser Phe Leu Ile Glu Ile Thr Arg Asp Ile 
225                 230                 235                 240 


Leu Lys Phe Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met 
                245                 250                 255     


Asp Thr Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala 
            260                 265                 270         


Leu Asp Leu Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala 
        275                 280                 285             


Arg Cys Leu Ser Ala Ile Lys Asp Glu Arg Lys Arg Ala Ser Lys Leu 
    290                 295                 300                 


Leu Ala Gly Pro Thr Val Pro Lys Asp Ala Ile His Asp Arg Glu Gln 
305                 310                 315                 320 


Phe Val Tyr Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser 
                325                 330                 335     


Tyr Ala Gln Gly Phe Met Leu Ile Arg Glu Ala Ala Arg Ser Tyr Gly 
            340                 345                 350         


Trp Lys Leu Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys 
        355                 360                 365             


Ile Ile Arg Ser Val Phe Leu Ala Glu Ile Thr Lys Ala Tyr Arg Asp 
    370                 375                 380                 


Asp Pro Asp Leu Glu Asn Leu Leu Phe Asn Glu Phe Phe Ala Ser Ala 
385                 390                 395                 400 


Val Thr Lys Ala Gln Ser Gly Trp Arg Arg Thr Ile Ala Leu Ala Ala 
                405                 410                 415     


Thr Tyr Gly Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ala Phe Tyr 
            420                 425                 430         


Asp Gly Tyr Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln 
        435                 440                 445             


Arg Asp Tyr Phe Gly Ala His Thr Phe Arg Ile Leu Pro Glu Cys Ala 
    450                 455                 460                 


Ser Ala His Leu Pro Val Asp Lys Asp Ile His Ile Asn Trp Thr Gly 
465                 470                 475                 480 


His Gly Gly Asn Ile Ser Ser Ser Thr Tyr Gln Ala 
                485                 490         


<210>  6
<211>  500
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Thr Lys Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Thr Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ala 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala Arg Gly Asp Val Thr Ile 
        115                 120                 125             


Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Val Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu 
145                 150                 155                 160 


Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 
                165                 170                 175     


Met Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu Thr Asn Asp Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Ser 
                245                 250                 255     


Val Ala Val Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile Lys 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys Val 
                325                 330                 335     


Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn Arg 
            340                 345                 350         


Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys Glu 
        355                 360                 365             


Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly Tyr 
    370                 375                 380                 


Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Asn Glu Asp Met Arg Ile 
385                 390                 395                 400 


Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 
                405                 410                 415     


Thr Leu Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly Leu 
            420                 425                 430         


Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala 
        435                 440                 445             


Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe 
    450                 455                 460                 


Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg 
465                 470                 475                 480 


Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala Val 
                485                 490                 495     


Arg Ile Lys Leu 
            500 


<210>  7
<211>  428
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  7

Met Ser Met Leu Ser Arg Arg Leu Phe Ser Thr Ser Arg Leu Ala Ala 
1               5                   10                  15      


Phe Ser Lys Ile Lys Val Lys Gln Pro Val Val Glu Leu Asp Gly Asp 
            20                  25                  30          


Glu Met Thr Arg Ile Ile Trp Asp Lys Ile Lys Lys Lys Leu Ile Leu 
        35                  40                  45              


Pro Tyr Leu Asp Val Asp Leu Lys Tyr Tyr Asp Leu Ser Val Glu Ser 
    50                  55                  60                  


Arg Asp Ala Thr Ser Asp Lys Ile Thr Gln Asp Ala Ala Glu Ala Ile 
65                  70                  75                  80  


Lys Lys Tyr Gly Val Gly Ile Lys Cys Ala Thr Ile Thr Pro Asp Glu 
                85                  90                  95      


Ala Arg Val Lys Glu Phe Asn Leu His Lys Met Trp Lys Ser Pro Asn 
            100                 105                 110         


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Pro Ile 
        115                 120                 125             


Val Ile Pro Arg Ile Pro Arg Leu Val Pro Arg Trp Glu Lys Pro Ile 
    130                 135                 140                 


Ile Ile Gly Arg His Ala His Gly Asp Gln Tyr Lys Ala Thr Asp Thr 
145                 150                 155                 160 


Leu Ile Pro Gly Pro Gly Ser Leu Glu Leu Val Tyr Lys Pro Ser Asp 
                165                 170                 175     


Pro Thr Thr Ala Gln Pro Gln Thr Leu Lys Val Tyr Asp Tyr Lys Gly 
            180                 185                 190         


Ser Gly Val Ala Met Ala Met Tyr Asn Thr Asp Glu Ser Ile Glu Gly 
        195                 200                 205             


Phe Ala His Ser Ser Phe Lys Leu Ala Ile Asp Lys Lys Leu Asn Leu 
    210                 215                 220                 


Phe Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe 
225                 230                 235                 240 


Lys Asp Ile Phe Gln Glu Val Tyr Glu Ala Gln Tyr Lys Ser Lys Phe 
                245                 250                 255     


Glu Gln Leu Gly Ile His Tyr Glu His Arg Leu Ile Asp Asp Met Val 
            260                 265                 270         


Ala Gln Met Ile Lys Ser Lys Gly Gly Phe Ile Met Ala Leu Lys Asn 
        275                 280                 285             


Tyr Asp Gly Asp Val Gln Ser Asp Ile Val Ala Gln Gly Phe Gly Ser 
    290                 295                 300                 


Leu Gly Leu Met Thr Ser Ile Leu Val Thr Pro Asp Gly Lys Thr Phe 
305                 310                 315                 320 


Glu Ser Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Lys Tyr 
                325                 330                 335     


Gln Lys Gly Glu Glu Thr Ser Thr Asn Ser Ile Ala Ser Ile Phe Ala 
            340                 345                 350         


Trp Ser Arg Gly Leu Leu Lys Arg Gly Glu Leu Asp Asn Thr Pro Ala 
        355                 360                 365             


Leu Cys Lys Phe Ala Asn Ile Leu Glu Ser Ala Thr Leu Asn Thr Val 
    370                 375                 380                 


Gln Gln Asp Gly Ile Met Thr Lys Asp Leu Ala Leu Ala Cys Gly Asn 
385                 390                 395                 400 


Asn Glu Arg Ser Ala Tyr Val Thr Thr Glu Glu Phe Leu Asp Ala Val 
                405                 410                 415     


Glu Lys Arg Leu Gln Lys Glu Ile Lys Ser Ile Glu 
            420                 425             


<210>  8
<211>  412
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  8

Met Thr Lys Ile Lys Val Ala Asn Pro Ile Val Glu Met Asp Gly Asp 
1               5                   10                  15      


Glu Gln Thr Arg Ile Ile Trp His Leu Ile Arg Asp Lys Leu Val Leu 
            20                  25                  30          


Pro Tyr Leu Asp Val Asp Leu Lys Tyr Tyr Asp Leu Ser Val Glu Tyr 
        35                  40                  45              


Arg Asp Gln Thr Asn Asp Gln Val Thr Val Asp Ser Ala Thr Ala Thr 
    50                  55                  60                  


Leu Lys Tyr Gly Val Ala Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Ala Arg Val Glu Glu Phe His Leu Lys Lys Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Pro Ile 
            100                 105                 110         


Ile Ile Pro Arg Ile Pro Arg Leu Val Pro Gln Trp Glu Lys Pro Ile 
        115                 120                 125             


Ile Ile Gly Arg His Ala Phe Gly Asp Gln Tyr Lys Ala Thr Asp Val 
    130                 135                 140                 


Ile Val Pro Glu Glu Gly Glu Leu Arg Leu Val Tyr Lys Ser Lys Ser 
145                 150                 155                 160 


Gly Thr His Asp Val Asp Leu Lys Val Phe Asp Tyr Pro Glu His Gly 
                165                 170                 175     


Gly Val Ala Met Met Met Tyr Asn Thr Thr Asp Ser Ile Glu Gly Phe 
            180                 185                 190         


Ala Lys Ala Ser Phe Glu Leu Ala Ile Glu Arg Lys Leu Pro Leu Tyr 
        195                 200                 205             


Ser Thr Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Lys Phe Lys 
    210                 215                 220                 


Asp Val Phe Glu Ala Met Tyr Ala Arg Ser Tyr Lys Glu Lys Phe Glu 
225                 230                 235                 240 


Ser Leu Gly Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     


Gln Met Leu Lys Ser Lys Gly Gly Tyr Ile Ile Ala Met Lys Asn Tyr 
            260                 265                 270         


Asp Gly Asp Val Glu Ser Asp Ile Val Ala Gln Gly Phe Gly Ser Leu 
        275                 280                 285             


Gly Leu Met Thr Ser Val Leu Ile Thr Pro Asp Gly Lys Thr Phe Glu 
    290                 295                 300                 


Ser Glu Ala Ala His Gly Thr Val Thr Arg His Phe Arg Gln His Gln 
305                 310                 315                 320 


Gln Gly Lys Glu Thr Ser Thr Asn Ser Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     


Thr Arg Gly Ile Ile Gln Arg Gly Lys Leu Asp Asn Thr Pro Asp Val 
            340                 345                 350         


Val Lys Phe Gly Gln Ile Leu Glu Ser Ala Thr Val Asn Thr Val Gln 
        355                 360                 365             


Glu Asp Gly Ile Met Thr Lys Asp Leu Ala Leu Ile Leu Gly Lys Ser 
    370                 375                 380                 


Glu Arg Ser Ala Tyr Val Thr Thr Glu Glu Phe Ile Asp Ala Val Glu 
385                 390                 395                 400 


Ser Arg Leu Lys Lys Glu Phe Glu Ala Ala Ala Leu 
                405                 410         


<210>  9
<211>  420
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Ser Lys Ile Lys Val Val His Pro Ile Val Glu Met Asp Gly Asp 
1               5                   10                  15      


Glu Gln Thr Arg Val Ile Trp Lys Leu Ile Lys Glu Lys Leu Ile Leu 
            20                  25                  30          


Pro Tyr Leu Asp Val Asp Leu Lys Tyr Tyr Asp Leu Ser Ile Gln Glu 
        35                  40                  45              


Arg Asp Arg Thr Asn Asp Gln Val Thr Lys Asp Ser Ser Tyr Ala Thr 
    50                  55                  60                  


Leu Lys Tyr Gly Val Ala Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Ala Arg Met Lys Glu Phe Asn Leu Lys Glu Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Pro Ile 
            100                 105                 110         


Ile Ile Pro Lys Ile Pro Arg Leu Val Pro His Trp Glu Lys Pro Ile 
        115                 120                 125             


Ile Ile Gly Arg His Ala Phe Gly Asp Gln Tyr Arg Ala Thr Asp Ile 
    130                 135                 140                 


Lys Ile Lys Lys Ala Gly Lys Leu Arg Leu Gln Phe Ser Ser Asp Asp 
145                 150                 155                 160 


Gly Lys Glu Asn Ile Asp Leu Lys Val Tyr Glu Phe Pro Lys Ser Gly 
                165                 170                 175     


Gly Ile Ala Met Ala Met Phe Asn Thr Asn Asp Ser Ile Lys Gly Phe 
            180                 185                 190         


Ala Lys Ala Ser Phe Glu Leu Ala Leu Lys Arg Lys Leu Pro Leu Phe 
        195                 200                 205             


Phe Thr Thr Lys Asn Thr Ile Leu Lys Asn Tyr Asp Asn Gln Phe Lys 
    210                 215                 220                 


Gln Ile Phe Asp Asn Leu Phe Asp Lys Glu Tyr Lys Glu Lys Phe Gln 
225                 230                 235                 240 


Ala Leu Lys Ile Thr Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     


Gln Met Leu Lys Ser Lys Gly Gly Phe Ile Ile Ala Met Lys Asn Tyr 
            260                 265                 270         


Asp Gly Asp Val Gln Ser Asp Ile Val Ala Gln Gly Phe Gly Ser Leu 
        275                 280                 285             


Gly Leu Met Thr Ser Ile Leu Ile Thr Pro Asp Gly Lys Thr Phe Glu 
    290                 295                 300                 


Ser Glu Ala Ala His Gly Thr Val Thr Arg His Phe Arg Lys His Gln 
305                 310                 315                 320 


Arg Gly Glu Glu Thr Ser Thr Asn Ser Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     


Thr Arg Ala Ile Ile Gln Arg Gly Lys Leu Asp Asn Thr Asp Asp Val 
            340                 345                 350         


Ile Lys Phe Gly Asn Leu Leu Glu Lys Ala Thr Leu Asp Thr Val Gln 
        355                 360                 365             


Val Gly Gly Lys Met Thr Lys Asp Leu Ala Leu Met Leu Gly Lys Thr 
    370                 375                 380                 


Asn Arg Ser Ser Tyr Val Thr Thr Glu Glu Phe Ile Asp Glu Val Ala 
385                 390                 395                 400 


Lys Arg Leu Gln Asn Met Met Leu Ser Ser Asn Glu Asp Lys Lys Gly 
                405                 410                 415     


Met Cys Lys Leu 
            420 


<210>  10
<211>  910
<212>  PRT
<213>  Bifidobacterium adolescentis

<400>  10

Met Ala Asp Ala Lys Lys Lys Glu Glu Pro Thr Lys Pro Thr Pro Glu 
1               5                   10                  15      


Glu Lys Leu Ala Ala Ala Glu Ala Glu Val Asp Ala Leu Val Lys Lys 
            20                  25                  30          


Gly Leu Lys Ala Leu Asp Glu Phe Glu Lys Leu Asp Gln Lys Gln Val 
        35                  40                  45              


Asp His Ile Val Ala Lys Ala Ser Val Ala Ala Leu Asn Lys His Leu 
    50                  55                  60                  


Val Leu Ala Lys Met Ala Val Glu Glu Thr His Arg Gly Leu Val Glu 
65                  70                  75                  80  


Asp Lys Ala Thr Lys Asn Ile Phe Ala Cys Glu His Val Thr Asn Tyr 
                85                  90                  95      


Leu Ala Gly Gln Lys Thr Val Gly Ile Ile Arg Glu Asp Asp Val Leu 
            100                 105                 110         


Gly Ile Asp Glu Ile Ala Glu Pro Val Gly Val Val Ala Gly Val Thr 
        115                 120                 125             


Pro Val Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Ser Leu Ile Ala 
    130                 135                 140                 


Leu Lys Thr Arg Cys Pro Ile Ile Phe Gly Phe His Pro Gly Ala Gln 
145                 150                 155                 160 


Asn Cys Ser Val Ala Ala Ala Lys Ile Val Arg Asp Ala Ala Ile Ala 
                165                 170                 175     


Ala Gly Ala Pro Glu Asn Cys Ile Gln Trp Ile Glu His Pro Ser Ile 
            180                 185                 190         


Glu Ala Thr Gly Ala Leu Met Lys His Asp Gly Val Ala Thr Ile Leu 
        195                 200                 205             


Ala Thr Gly Gly Pro Gly Met Val Lys Ala Ala Tyr Ser Ser Gly Lys 
    210                 215                 220                 


Pro Ala Leu Gly Val Gly Ala Gly Asn Ala Pro Ala Tyr Val Asp Lys 
225                 230                 235                 240 


Asn Val Asp Val Val Arg Ala Ala Asn Asp Leu Ile Leu Ser Lys His 
                245                 250                 255     


Phe Asp Tyr Gly Met Ile Cys Ala Thr Glu Gln Ala Ile Ile Ala Asp 
            260                 265                 270         


Lys Asp Ile Tyr Ala Pro Leu Val Lys Glu Leu Lys Arg Arg Lys Ala 
        275                 280                 285             


Tyr Phe Val Asn Ala Asp Glu Lys Ala Lys Leu Glu Gln Tyr Met Phe 
    290                 295                 300                 


Gly Cys Thr Ala Tyr Ser Gly Gln Thr Pro Lys Leu Asn Ser Val Val 
305                 310                 315                 320 


Pro Gly Lys Ser Pro Gln Tyr Ile Ala Lys Ala Ala Gly Phe Glu Ile 
                325                 330                 335     


Pro Glu Asp Ala Thr Ile Leu Ala Ala Glu Cys Lys Glu Val Gly Glu 
            340                 345                 350         


Asn Glu Pro Leu Thr Met Glu Lys Leu Ala Pro Val Gln Ala Val Leu 
        355                 360                 365             


Lys Ser Asp Asn Lys Glu Gln Ala Phe Glu Met Cys Glu Ala Met Leu 
    370                 375                 380                 


Lys His Gly Ala Gly His Thr Ala Ala Ile His Thr Asn Asp Arg Asp 
385                 390                 395                 400 


Leu Val Arg Glu Tyr Gly Gln Arg Met His Ala Cys Arg Ile Ile Trp 
                405                 410                 415     


Asn Ser Pro Ser Ser Leu Gly Gly Val Gly Asp Ile Tyr Asn Ala Ile 
            420                 425                 430         


Ala Pro Ser Leu Thr Leu Gly Cys Gly Ser Tyr Gly Gly Asn Ser Val 
        435                 440                 445             


Ser Gly Asn Val Gln Ala Val Asn Leu Ile Asn Ile Lys Arg Ile Ala 
    450                 455                 460                 


Arg Arg Asn Asn Asn Met Gln Trp Phe Lys Ile Pro Ala Lys Thr Tyr 
465                 470                 475                 480 


Phe Glu Pro Asn Ala Ile Lys Tyr Leu Arg Asp Met Tyr Gly Ile Glu 
                485                 490                 495     


Lys Ala Val Ile Val Cys Asp Lys Val Met Glu Gln Leu Gly Ile Val 
            500                 505                 510         


Asp Lys Ile Ile Asp Gln Leu Arg Ala Arg Ser Asn Arg Val Thr Phe 
        515                 520                 525             


Arg Ile Ile Asp Tyr Val Glu Pro Glu Pro Ser Val Glu Thr Val Glu 
    530                 535                 540                 


Arg Gly Ala Ala Met Met Arg Glu Glu Phe Glu Pro Asp Thr Ile Ile 
545                 550                 555                 560 


Ala Val Gly Gly Gly Ser Pro Met Asp Ala Ser Lys Ile Met Trp Leu 
                565                 570                 575     


Leu Tyr Glu His Pro Glu Ile Ser Phe Ser Asp Val Arg Glu Lys Phe 
            580                 585                 590         


Phe Asp Ile Arg Lys Arg Ala Phe Lys Ile Pro Pro Leu Gly Lys Lys 
        595                 600                 605             


Ala Lys Leu Val Cys Ile Pro Thr Ser Ser Gly Thr Gly Ser Glu Val 
    610                 615                 620                 


Thr Pro Phe Ala Val Ile Thr Asp His Lys Thr Gly Tyr Lys Tyr Pro 
625                 630                 635                 640 


Ile Thr Asp Tyr Ala Leu Thr Pro Ser Val Ala Ile Val Asp Pro Val 
                645                 650                 655     


Leu Ala Arg Thr Gln Pro Arg Lys Leu Ala Ser Asp Ala Gly Phe Asp 
            660                 665                 670         


Ala Leu Thr His Ala Phe Glu Ala Tyr Val Ser Val Tyr Ala Asn Asp 
        675                 680                 685             


Phe Thr Asp Gly Met Ala Leu His Ala Ala Lys Leu Val Trp Asp Asn 
    690                 695                 700                 


Leu Ala Glu Ser Val Asn Gly Glu Pro Gly Glu Glu Lys Thr Arg Ala 
705                 710                 715                 720 


Gln Glu Lys Met His Asn Ala Ala Thr Met Ala Gly Met Ala Phe Gly 
                725                 730                 735     


Ser Ala Phe Leu Gly Met Cys His Gly Met Ala His Thr Ile Gly Ala 
            740                 745                 750         


Leu Cys His Val Ala His Gly Arg Thr Asn Ser Ile Leu Leu Pro Tyr 
        755                 760                 765             


Val Ile Arg Tyr Asn Gly Ser Val Pro Glu Glu Pro Thr Ser Trp Pro 
    770                 775                 780                 


Lys Tyr Asn Lys Tyr Ile Ala Pro Glu Arg Tyr Gln Glu Ile Ala Lys 
785                 790                 795                 800 


Asn Leu Gly Val Asn Pro Gly Lys Thr Pro Glu Glu Gly Val Glu Asn 
                805                 810                 815     


Leu Ala Lys Ala Val Glu Asp Tyr Arg Asp Asn Lys Leu Gly Met Asn 
            820                 825                 830         


Lys Ser Phe Gln Glu Cys Gly Val Asp Glu Asp Tyr Tyr Trp Ser Ile 
        835                 840                 845             


Ile Asp Gln Ile Gly Met Arg Ala Tyr Glu Asp Gln Cys Ala Pro Ala 
    850                 855                 860                 


Asn Pro Arg Ile Pro Gln Ile Glu Asp Met Lys Asp Ile Ala Ile Ala 
865                 870                 875                 880 


Ala Tyr Tyr Gly Val Ser Gln Ala Glu Gly His Lys Leu Arg Val Gln 
                885                 890                 895     


Arg Gln Gly Glu Ala Ala Thr Glu Glu Ala Ser Glu Arg Ala 
            900                 905                 910 


<210>  11
<211>  1092
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  11

Met Leu Phe Asp Asn Lys Asn Arg Gly Ala Leu Asn Ser Leu Asn Thr 
1               5                   10                  15      


Pro Asp Ile Ala Ser Leu Ser Ile Ser Ser Met Ser Asp Tyr His Val 
            20                  25                  30          


Phe Asp Phe Pro Gly Lys Asp Leu Gln Arg Glu Glu Val Ile Asp Leu 
        35                  40                  45              


Leu Asp Gln Gln Gly Phe Ile Pro Asp Asp Leu Ile Glu Gln Glu Val 
    50                  55                  60                  


Asp Trp Phe Tyr Asn Ser Leu Gly Ile Asp Asp Leu Phe Phe Ser Arg 
65                  70                  75                  80  


Glu Ser Pro Gln Leu Ile Ser Asn Ile Ile His Ser Leu Tyr Ala Ser 
                85                  90                  95      


Lys Leu Asp Phe Phe Ala Lys Ser Lys Phe Asn Gly Ile Gln Pro Arg 
            100                 105                 110         


Leu Phe Ser Ile Lys Asn Lys Ile Ile Thr Asn Asp Asn His Ala Ile 
        115                 120                 125             


Phe Met Glu Ser Asn Thr Gly Val Ser Ile Ser Asp Ser Gln Gln Lys 
    130                 135                 140                 


Asn Phe Lys Phe Ala Ser Asp Ala Val Gly Asn Asp Thr Leu Glu His 
145                 150                 155                 160 


Gly Lys Asp Thr Ile Lys Lys Asn Arg Ile Glu Met Asp Asp Ser Cys 
                165                 170                 175     


Pro Pro Tyr Glu Leu Asp Ser Glu Ile Asp Asp Leu Phe Leu Asp Asn 
            180                 185                 190         


Lys Ser Gln Lys Asn Cys Arg Leu Val Ser Phe Trp Ala Pro Glu Ser 
        195                 200                 205             


Glu Leu Lys Leu Thr Phe Val Tyr Glu Ser Val Tyr Pro Asn Asp Asp 
    210                 215                 220                 


Pro Ala Gly Val Asp Ile Ser Ser Gln Asp Leu Leu Lys Gly Asp Ile 
225                 230                 235                 240 


Glu Ser Ile Ser Asp Lys Thr Met Tyr Lys Val Ser Ser Asn Glu Asn 
                245                 250                 255     


Lys Lys Leu Tyr Gly Leu Leu Leu Lys Leu Val Lys Glu Arg Glu Gly 
            260                 265                 270         


Pro Val Ile Lys Thr Thr Arg Ser Val Glu Asn Lys Asp Glu Ile Arg 
        275                 280                 285             


Leu Leu Val Ala Tyr Lys Arg Phe Thr Thr Lys Arg Tyr Tyr Ser Ala 
    290                 295                 300                 


Leu Asn Ser Leu Phe His Tyr Tyr Lys Leu Lys Pro Ser Lys Phe Tyr 
305                 310                 315                 320 


Leu Glu Ser Phe Asn Val Lys Asp Asp Asp Ile Ile Ile Phe Ser Val 
                325                 330                 335     


Tyr Leu Asn Glu Asn Gln Gln Leu Glu Asp Val Leu Leu His Asp Val 
            340                 345                 350         


Glu Ala Ala Leu Lys Gln Val Glu Arg Glu Ala Ser Leu Leu Tyr Ala 
        355                 360                 365             


Ile Pro Asn Asn Ser Phe His Glu Val Tyr Gln Arg Arg Gln Phe Ser 
    370                 375                 380                 


Pro Lys Glu Ala Ile Tyr Ala His Ile Gly Ala Ile Phe Ile Asn His 
385                 390                 395                 400 


Phe Val Asn Arg Leu Gly Ser Asp Tyr Gln Asn Leu Leu Ser Gln Ile 
                405                 410                 415     


Thr Ile Lys Arg Asn Asp Thr Thr Leu Leu Glu Ile Val Glu Asn Leu 
            420                 425                 430         


Lys Arg Lys Leu Arg Asn Glu Thr Leu Thr Gln Gln Thr Ile Ile Asn 
        435                 440                 445             


Ile Met Ser Lys His Tyr Thr Ile Ile Ser Lys Leu Tyr Lys Asn Phe 
    450                 455                 460                 


Ala Gln Ile His Tyr Tyr His Asn Ser Thr Lys Asp Met Glu Lys Thr 
465                 470                 475                 480 


Leu Ser Phe Gln Arg Leu Glu Lys Val Glu Pro Phe Lys Asn Asp Gln 
                485                 490                 495     


Glu Phe Glu Ala Tyr Leu Asn Lys Phe Ile Pro Asn Asp Ser Pro Asp 
            500                 505                 510         


Leu Leu Ile Leu Lys Thr Leu Asn Ile Phe Asn Lys Ser Ile Leu Lys 
        515                 520                 525             


Thr Asn Phe Phe Ile Thr Arg Lys Val Ala Ile Ser Phe Arg Leu Asp 
    530                 535                 540                 


Pro Ser Leu Val Met Thr Lys Phe Glu Tyr Pro Glu Thr Pro Tyr Gly 
545                 550                 555                 560 


Ile Phe Phe Val Val Gly Asn Thr Phe Lys Gly Phe His Ile Arg Phe 
                565                 570                 575     


Arg Asp Ile Ala Arg Gly Gly Ile Arg Ile Val Cys Ser Arg Asn Gln 
            580                 585                 590         


Asp Ile Tyr Asp Leu Asn Ser Lys Asn Val Ile Asp Glu Asn Tyr Gln 
        595                 600                 605             


Leu Ala Ser Thr Gln Gln Arg Lys Asn Lys Asp Ile Pro Glu Gly Gly 
    610                 615                 620                 


Ser Lys Gly Val Ile Leu Leu Asn Pro Gly Leu Val Glu His Asp Gln 
625                 630                 635                 640 


Thr Phe Val Ala Phe Ser Gln Tyr Val Asp Ala Met Ile Asp Ile Leu 
                645                 650                 655     


Ile Asn Asp Pro Leu Lys Glu Asn Tyr Val Asn Leu Leu Pro Lys Glu 
            660                 665                 670         


Glu Ile Leu Phe Phe Gly Pro Asp Glu Gly Thr Ala Gly Phe Val Asp 
        675                 680                 685             


Trp Ala Thr Asn His Ala Arg Val Arg Asn Cys Pro Trp Trp Lys Ser 
    690                 695                 700                 


Phe Leu Thr Gly Lys Ser Pro Ser Leu Gly Gly Ile Pro His Asp Glu 
705                 710                 715                 720 


Tyr Gly Met Thr Ser Leu Gly Val Arg Ala Tyr Val Asn Lys Ile Tyr 
                725                 730                 735     


Glu Thr Leu Asn Leu Thr Asn Ser Thr Val Tyr Lys Phe Gln Thr Gly 
            740                 745                 750         


Gly Pro Asp Gly Asp Leu Gly Ser Asn Glu Ile Leu Leu Ser Ser Pro 
        755                 760                 765             


Asn Glu Cys Tyr Leu Ala Ile Leu Asp Gly Ser Gly Val Leu Cys Asp 
    770                 775                 780                 


Pro Lys Gly Leu Asp Lys Asp Glu Leu Cys Arg Leu Ala His Glu Arg 
785                 790                 795                 800 


Lys Met Ile Ser Asp Phe Asp Thr Ser Lys Leu Ser Asn Asn Gly Phe 
                805                 810                 815     


Phe Val Ser Val Asp Ala Met Asp Ile Met Leu Pro Asn Gly Thr Ile 
            820                 825                 830         


Val Ala Asn Gly Thr Thr Phe Arg Asn Thr Phe His Thr Gln Ile Phe 
        835                 840                 845             


Lys Phe Val Asp His Val Asp Ile Phe Val Pro Cys Gly Gly Arg Pro 
    850                 855                 860                 


Asn Ser Ile Thr Leu Asn Asn Leu His Tyr Phe Val Asp Glu Lys Thr 
865                 870                 875                 880 


Gly Lys Cys Lys Ile Pro Tyr Ile Val Glu Gly Ala Asn Leu Phe Ile 
                885                 890                 895     


Thr Gln Pro Ala Lys Asn Ala Leu Glu Glu His Gly Cys Ile Leu Phe 
            900                 905                 910         


Lys Asp Ala Ser Ala Asn Lys Gly Gly Val Thr Ser Ser Ser Met Glu 
        915                 920                 925             


Val Leu Ala Ser Leu Ala Leu Asn Asp Asn Asp Phe Val His Lys Phe 
    930                 935                 940                 


Ile Gly Asp Val Ser Gly Glu Arg Ser Ala Leu Tyr Lys Ser Tyr Val 
945                 950                 955                 960 


Val Glu Val Gln Ser Arg Ile Gln Lys Asn Ala Glu Leu Glu Phe Gly 
                965                 970                 975     


Gln Leu Trp Asn Leu Asn Gln Leu Asn Gly Thr His Ile Ser Glu Ile 
            980                 985                 990         


Ser Asn Gln Leu Ser Phe Thr Ile  Asn Lys Leu Asn Asp  Asp Leu Val 
        995                 1000                 1005             


Ala Ser  Gln Glu Leu Trp Leu  Asn Asp Leu Lys Leu  Arg Asn Tyr 
    1010                 1015                 1020             


Leu Leu  Leu Asp Lys Ile Ile  Pro Lys Ile Leu Ile  Asp Val Ala 
    1025                 1030                 1035             


Gly Pro  Gln Ser Val Leu Glu  Asn Ile Pro Glu Ser  Tyr Leu Lys 
    1040                 1045                 1050             


Val Leu  Leu Ser Ser Tyr Leu  Ser Ser Thr Phe Val  Tyr Gln Asn 
    1055                 1060                 1065             


Gly Ile  Asp Val Asn Ile Gly  Lys Phe Leu Glu Phe  Ile Gly Gly 
    1070                 1075                 1080             


Leu Lys  Arg Glu Ala Glu Ala  Ser Ala 
    1085                 1090         


<210>  12
<211>  348
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  12

Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His 
1               5                   10                  15      


Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn 
            20                  25                  30          


Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu 
        35                  40                  45              


His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val 
    50                  55                  60                  


Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val 
65                  70                  75                  80  


Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly 
                85                  90                  95      


Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys 
            100                 105                 110         


Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln 
        115                 120                 125             


Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr 
    130                 135                 140                 


Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr 
145                 150                 155                 160 


Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile 
                165                 170                 175     


Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys 
            180                 185                 190         


Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu 
        195                 200                 205             


Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys 
    210                 215                 220                 


Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala 
225                 230                 235                 240 


His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser 
                245                 250                 255     


Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro 
            260                 265                 270         


Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser 
        275                 280                 285             


Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu 
    290                 295                 300                 


Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val 
305                 310                 315                 320 


Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly 
                325                 330                 335     


Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys 
            340                 345             


<210>  13
<211>  348
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  13

Met Ser Ile Pro Glu Thr Gln Lys Ala Ile Ile Phe Tyr Glu Ser Asn 
1               5                   10                  15      


Gly Lys Leu Glu His Lys Asp Ile Pro Val Pro Lys Pro Lys Pro Asn 
            20                  25                  30          


Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu 
        35                  40                  45              


His Ala Trp His Gly Asp Trp Pro Leu Pro Thr Lys Leu Pro Leu Val 
    50                  55                  60                  


Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val 
65                  70                  75                  80  


Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly 
                85                  90                  95      


Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys 
            100                 105                 110         


Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Glu 
        115                 120                 125             


Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr 
    130                 135                 140                 


Asp Leu Ala Glu Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr 
145                 150                 155                 160 


Lys Ala Leu Lys Ser Ala Asn Leu Arg Ala Gly His Trp Ala Ala Ile 
                165                 170                 175     


Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys 
            180                 185                 190         


Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Pro Gly Lys Glu 
        195                 200                 205             


Glu Leu Phe Thr Ser Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys 
    210                 215                 220                 


Glu Lys Asp Ile Val Ser Ala Val Val Lys Ala Thr Asn Gly Gly Ala 
225                 230                 235                 240 


His Gly Ile Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser 
                245                 250                 255     


Thr Arg Tyr Cys Arg Ala Asn Gly Thr Val Val Leu Val Gly Leu Pro 
            260                 265                 270         


Ala Gly Ala Lys Cys Ser Ser Asp Val Phe Asn His Val Val Lys Ser 
        275                 280                 285             


Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu 
    290                 295                 300                 


Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val 
305                 310                 315                 320 


Val Gly Leu Ser Ser Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly 
                325                 330                 335     


Gln Ile Ala Gly Arg Tyr Val Val Asp Thr Ser Lys 
            340                 345             


<210>  14
<211>  375
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Leu Arg Thr Ser Thr Leu Phe Thr Arg Arg Val Gln Pro Ser Leu 
1               5                   10                  15      


Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys 
            20                  25                  30          


Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Lys Leu His Tyr 
        35                  40                  45              


Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn 
    50                  55                  60                  


Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly 
65                  70                  75                  80  


Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly 
                85                  90                  95      


Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val 
            100                 105                 110         


Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys 
        115                 120                 125             


Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu 
    130                 135                 140                 


Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp 
145                 150                 155                 160 


Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val 
                165                 170                 175     


Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu 
            180                 185                 190         


Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly 
        195                 200                 205             


Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg 
    210                 215                 220                 


Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys 
225                 230                 235                 240 


Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val 
                245                 250                 255     


Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn 
            260                 265                 270         


Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg 
        275                 280                 285             


Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val 
    290                 295                 300                 


Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly 
305                 310                 315                 320 


Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe 
                325                 330                 335     


Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu 
            340                 345                 350         


Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg 
        355                 360                 365             


Tyr Val Val Asp Thr Ser Lys 
    370                 375 


<210>  15
<211>  382
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Ser Ser Val Thr Gly Phe Tyr Ile Pro Pro Ile Ser Phe Phe Gly 
1               5                   10                  15      


Glu Gly Ala Leu Glu Glu Thr Ala Asp Tyr Ile Lys Asn Lys Asp Tyr 
            20                  25                  30          


Lys Lys Ala Leu Ile Val Thr Asp Pro Gly Ile Ala Ala Ile Gly Leu 
        35                  40                  45              


Ser Gly Arg Val Gln Lys Met Leu Glu Glu Arg Asp Leu Asn Val Ala 
    50                  55                  60                  


Ile Tyr Asp Lys Thr Gln Pro Asn Pro Asn Ile Ala Asn Val Thr Ala 
65                  70                  75                  80  


Gly Leu Lys Val Leu Lys Glu Gln Asn Ser Glu Ile Val Val Ser Ile 
                85                  90                  95      


Gly Gly Gly Ser Ala His Asp Asn Ala Lys Ala Ile Ala Leu Leu Ala 
            100                 105                 110         


Thr Asn Gly Gly Glu Ile Gly Asp Tyr Glu Gly Val Asn Gln Ser Lys 
        115                 120                 125             


Lys Ala Ala Leu Pro Leu Phe Ala Ile Asn Thr Thr Ala Gly Thr Ala 
    130                 135                 140                 


Ser Glu Met Thr Arg Phe Thr Ile Ile Ser Asn Glu Glu Lys Lys Ile 
145                 150                 155                 160 


Lys Met Ala Ile Ile Asp Asn Asn Val Thr Pro Ala Val Ala Val Asn 
                165                 170                 175     


Asp Pro Ser Thr Met Phe Gly Leu Pro Pro Ala Leu Thr Ala Ala Thr 
            180                 185                 190         


Gly Leu Asp Ala Leu Thr His Cys Ile Glu Ala Tyr Val Ser Thr Ala 
        195                 200                 205             


Ser Asn Pro Ile Thr Asp Ala Cys Ala Leu Lys Gly Ile Asp Leu Ile 
    210                 215                 220                 


Asn Glu Ser Leu Val Ala Ala Tyr Lys Asp Gly Lys Asp Lys Lys Ala 
225                 230                 235                 240 


Arg Thr Asp Met Cys Tyr Ala Glu Tyr Leu Ala Gly Met Ala Phe Asn 
                245                 250                 255     


Asn Ala Ser Leu Gly Tyr Val His Ala Leu Ala His Gln Leu Gly Gly 
            260                 265                 270         


Phe Tyr His Leu Pro His Gly Val Cys Asn Ala Val Leu Leu Pro His 
        275                 280                 285             


Val Gln Glu Ala Asn Met Gln Cys Pro Lys Ala Lys Lys Arg Leu Gly 
    290                 295                 300                 


Glu Ile Ala Leu His Phe Gly Ala Ser Gln Glu Asp Pro Glu Glu Thr 
305                 310                 315                 320 


Ile Lys Ala Leu His Val Leu Asn Arg Thr Met Asn Ile Pro Arg Asn 
                325                 330                 335     


Leu Lys Glu Leu Gly Val Lys Thr Glu Asp Phe Glu Ile Leu Ala Glu 
            340                 345                 350         


His Ala Met His Asp Ala Cys His Leu Thr Asn Pro Val Gln Phe Thr 
        355                 360                 365             


Lys Glu Gln Val Val Ala Ile Ile Lys Lys Ala Tyr Glu Tyr 
    370                 375                 380         


<210>  16
<211>  351
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  16

Met Pro Ser Gln Val Ile Pro Glu Lys Gln Lys Ala Ile Val Phe Tyr 
1               5                   10                  15      


Glu Thr Asp Gly Lys Leu Glu Tyr Lys Asp Val Thr Val Pro Glu Pro 
            20                  25                  30          


Lys Pro Asn Glu Ile Leu Val His Val Lys Tyr Ser Gly Val Cys His 
        35                  40                  45              


Ser Asp Leu His Ala Trp His Gly Asp Trp Pro Phe Gln Leu Lys Phe 
    50                  55                  60                  


Pro Leu Ile Gly Gly His Glu Gly Ala Gly Val Val Val Lys Leu Gly 
65                  70                  75                  80  


Ser Asn Val Lys Gly Trp Lys Val Gly Asp Phe Ala Gly Ile Lys Trp 
                85                  90                  95      


Leu Asn Gly Thr Cys Met Ser Cys Glu Tyr Cys Glu Val Gly Asn Glu 
            100                 105                 110         


Ser Gln Cys Pro Tyr Leu Asp Gly Thr Gly Phe Thr His Asp Gly Thr 
        115                 120                 125             


Phe Gln Glu Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro 
    130                 135                 140                 


Pro Asn Val Asn Leu Ala Glu Val Ala Pro Ile Leu Cys Ala Gly Ile 
145                 150                 155                 160 


Thr Val Tyr Lys Ala Leu Lys Arg Ala Asn Val Ile Pro Gly Gln Trp 
                165                 170                 175     


Val Thr Ile Ser Gly Ala Cys Gly Gly Leu Gly Ser Leu Ala Ile Gln 
            180                 185                 190         


Tyr Ala Leu Ala Met Gly Tyr Arg Val Ile Gly Ile Asp Gly Gly Asn 
        195                 200                 205             


Ala Lys Arg Lys Leu Phe Glu Gln Leu Gly Gly Glu Ile Phe Ile Asp 
    210                 215                 220                 


Phe Thr Glu Glu Lys Asp Ile Val Gly Ala Ile Ile Lys Ala Thr Asn 
225                 230                 235                 240 


Gly Gly Ser His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile 
                245                 250                 255     


Glu Ala Ser Thr Arg Tyr Cys Arg Pro Asn Gly Thr Val Val Leu Val 
            260                 265                 270         


Gly Met Pro Ala His Ala Tyr Cys Asn Ser Asp Val Phe Asn Gln Val 
        275                 280                 285             


Val Lys Ser Ile Ser Ile Val Gly Ser Cys Val Gly Asn Arg Ala Asp 
    290                 295                 300                 


Thr Arg Glu Ala Leu Asp Phe Phe Ala Arg Gly Leu Ile Lys Ser Pro 
305                 310                 315                 320 


Ile His Leu Ala Gly Leu Ser Asp Val Pro Glu Ile Phe Ala Lys Met 
                325                 330                 335     


Glu Lys Gly Glu Ile Val Gly Arg Tyr Val Val Glu Thr Ser Lys 
            340                 345                 350     


<210>  17
<211>  360
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Ser Tyr Pro Glu Lys Phe Glu Gly Ile Ala Ile Gln Ser His Glu 
1               5                   10                  15      


Asp Trp Lys Asn Pro Lys Lys Thr Lys Tyr Asp Pro Lys Pro Phe Tyr 
            20                  25                  30          


Asp His Asp Ile Asp Ile Lys Ile Glu Ala Cys Gly Val Cys Gly Ser 
        35                  40                  45              


Asp Ile His Cys Ala Ala Gly His Trp Gly Asn Met Lys Met Pro Leu 
    50                  55                  60                  


Val Val Gly His Glu Ile Val Gly Lys Val Val Lys Leu Gly Pro Lys 
65                  70                  75                  80  


Ser Asn Ser Gly Leu Lys Val Gly Gln Arg Val Gly Val Gly Ala Gln 
                85                  90                  95      


Val Phe Ser Cys Leu Glu Cys Asp Arg Cys Lys Asn Asp Asn Glu Pro 
            100                 105                 110         


Tyr Cys Thr Lys Phe Val Thr Thr Tyr Ser Gln Pro Tyr Glu Asp Gly 
        115                 120                 125             


Tyr Val Ser Gln Gly Gly Tyr Ala Asn Tyr Val Arg Val His Glu His 
    130                 135                 140                 


Phe Val Val Pro Ile Pro Glu Asn Ile Pro Ser His Leu Ala Ala Pro 
145                 150                 155                 160 


Leu Leu Cys Gly Gly Leu Thr Val Tyr Ser Pro Leu Val Arg Asn Gly 
                165                 170                 175     


Cys Gly Pro Gly Lys Lys Val Gly Ile Val Gly Leu Gly Gly Ile Gly 
            180                 185                 190         


Ser Met Gly Thr Leu Ile Ser Lys Ala Met Gly Ala Glu Thr Tyr Val 
        195                 200                 205             


Ile Ser Arg Ser Ser Arg Lys Arg Glu Asp Ala Met Lys Met Gly Ala 
    210                 215                 220                 


Asp His Tyr Ile Ala Thr Leu Glu Glu Gly Asp Trp Gly Glu Lys Tyr 
225                 230                 235                 240 


Phe Asp Thr Phe Asp Leu Ile Val Val Cys Ala Ser Ser Leu Thr Asp 
                245                 250                 255     


Ile Asp Phe Asn Ile Met Pro Lys Ala Met Lys Val Gly Gly Arg Ile 
            260                 265                 270         


Val Ser Ile Ser Ile Pro Glu Gln His Glu Met Leu Ser Leu Lys Pro 
        275                 280                 285             


Tyr Gly Leu Lys Ala Val Ser Ile Ser Tyr Ser Ala Leu Gly Ser Ile 
    290                 295                 300                 


Lys Glu Leu Asn Gln Leu Leu Lys Leu Val Ser Glu Lys Asp Ile Lys 
305                 310                 315                 320 


Ile Trp Val Glu Thr Leu Pro Val Gly Glu Ala Gly Val His Glu Ala 
                325                 330                 335     


Phe Glu Arg Met Glu Lys Gly Asp Val Arg Tyr Arg Phe Thr Leu Val 
            340                 345                 350         


Gly Tyr Asp Lys Glu Phe Ser Asp 
        355                 360 


<210>  18
<211>  361
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  18

Met Leu Tyr Pro Glu Lys Phe Gln Gly Ile Gly Ile Ser Asn Ala Lys 
1               5                   10                  15      


Asp Trp Lys His Pro Lys Leu Val Ser Phe Asp Pro Lys Pro Phe Gly 
            20                  25                  30          


Asp His Asp Val Asp Val Glu Ile Glu Ala Cys Gly Ile Cys Gly Ser 
        35                  40                  45              


Asp Phe His Ile Ala Val Gly Asn Trp Gly Pro Val Pro Glu Asn Gln 
    50                  55                  60                  


Ile Leu Gly His Glu Ile Ile Gly Arg Val Val Lys Val Gly Ser Lys 
65                  70                  75                  80  


Cys His Thr Gly Val Lys Ile Gly Asp Arg Val Gly Val Gly Ala Gln 
                85                  90                  95      


Ala Leu Ala Cys Phe Glu Cys Glu Arg Cys Lys Ser Asp Asn Glu Gln 
            100                 105                 110         


Tyr Cys Thr Asn Asp His Val Leu Thr Met Trp Thr Pro Tyr Lys Asp 
        115                 120                 125             


Gly Tyr Ile Ser Gln Gly Gly Phe Ala Ser His Val Arg Leu His Glu 
    130                 135                 140                 


His Phe Ala Ile Gln Ile Pro Glu Asn Ile Pro Ser Pro Leu Ala Ala 
145                 150                 155                 160 


Pro Leu Leu Cys Gly Gly Ile Thr Val Phe Ser Pro Leu Leu Arg Asn 
                165                 170                 175     


Gly Cys Gly Pro Gly Lys Arg Val Gly Ile Val Gly Ile Gly Gly Ile 
            180                 185                 190         


Gly His Met Gly Ile Leu Leu Ala Lys Ala Met Gly Ala Glu Val Tyr 
        195                 200                 205             


Ala Phe Ser Arg Gly His Ser Lys Arg Glu Asp Ser Met Lys Leu Gly 
    210                 215                 220                 


Ala Asp His Tyr Ile Ala Met Leu Glu Asp Lys Gly Trp Thr Glu Gln 
225                 230                 235                 240 


Tyr Ser Asn Ala Leu Asp Leu Leu Val Val Cys Ser Ser Ser Leu Ser 
                245                 250                 255     


Lys Val Asn Phe Asp Ser Ile Val Lys Ile Met Lys Ile Gly Gly Ser 
            260                 265                 270         


Ile Val Ser Ile Ala Ala Pro Glu Val Asn Glu Lys Leu Val Leu Lys 
        275                 280                 285             


Pro Leu Gly Leu Met Gly Val Ser Ile Ser Ser Ser Ala Ile Gly Ser 
    290                 295                 300                 


Arg Lys Glu Ile Glu Gln Leu Leu Lys Leu Val Ser Glu Lys Asn Val 
305                 310                 315                 320 


Lys Ile Trp Val Glu Lys Leu Pro Ile Ser Glu Glu Gly Val Ser His 
                325                 330                 335     


Ala Phe Thr Arg Met Glu Ser Gly Asp Val Lys Tyr Arg Phe Thr Leu 
            340                 345                 350         


Val Asp Tyr Asp Lys Lys Phe His Lys 
        355                 360     


<210>  19
<211>  502
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Met Thr Lys Ser Asp Glu Thr Thr Ala Thr Ser Leu Asn Ala Lys Thr 
1               5                   10                  15      


Leu Lys Ser Phe Glu Ser Thr Leu Pro Ile Pro Thr Tyr Pro Arg Glu 
            20                  25                  30          


Gly Val Lys Gln Gly Ile Val His Leu Gly Val Gly Ala Phe His Arg 
        35                  40                  45              


Ser His Leu Ala Val Phe Met His Arg Leu Met Gln Glu His His Leu 
    50                  55                  60                  


Lys Asp Trp Ser Ile Cys Gly Val Gly Leu Met Lys Ala Asp Ala Leu 
65                  70                  75                  80  


Met Arg Asp Ala Met Lys Ala Gln Asp Cys Leu Tyr Thr Leu Val Glu 
                85                  90                  95      


Arg Gly Ile Lys Asp Thr Asn Ala Tyr Ile Val Gly Ser Ile Thr Ala 
            100                 105                 110         


Tyr Met Tyr Ala Pro Asp Asp Pro Arg Ala Val Ile Glu Lys Met Ala 
        115                 120                 125             


Asn Pro Asp Thr His Ile Val Ser Leu Thr Val Thr Glu Asn Gly Tyr 
    130                 135                 140                 


Tyr His Ser Glu Ala Thr Asn Ser Leu Met Thr Asp Ala Pro Glu Ile 
145                 150                 155                 160 


Ile Asn Asp Leu Asn His Pro Glu Lys Pro Asp Thr Leu Tyr Gly Tyr 
                165                 170                 175     


Leu Tyr Glu Ala Leu Leu Leu Arg Tyr Lys Arg Gly Leu Thr Pro Phe 
            180                 185                 190         


Thr Ile Met Ser Cys Asp Asn Met Pro Gln Asn Gly Val Thr Val Lys 
        195                 200                 205             


Thr Met Leu Val Ala Phe Ala Lys Leu Lys Lys Asp Glu Lys Phe Ala 
    210                 215                 220                 


Ala Trp Ile Glu Asp Lys Val Thr Ser Pro Asn Ser Met Val Asp Arg 
225                 230                 235                 240 


Val Thr Pro Arg Cys Thr Asp Lys Glu Arg Lys Tyr Val Ala Asp Thr 
                245                 250                 255     


Trp Gly Ile Lys Asp Gln Cys Pro Val Val Ala Glu Pro Phe Ile Gln 
            260                 265                 270         


Trp Val Leu Glu Asp Asn Phe Ser Asp Gly Arg Pro Pro Trp Glu Leu 
        275                 280                 285             


Val Gly Val Gln Val Val Lys Asp Val Asp Ser Tyr Glu Leu Met Lys 
    290                 295                 300                 


Leu Arg Leu Leu Asn Gly Gly His Ser Ala Met Gly Tyr Leu Gly Tyr 
305                 310                 315                 320 


Leu Ala Gly Tyr Thr Tyr Ile His Glu Val Val Asn Asp Pro Thr Ile 
                325                 330                 335     


Asn Lys Tyr Ile Arg Val Leu Met Arg Glu Glu Val Ile Pro Leu Leu 
            340                 345                 350         


Pro Lys Val Pro Gly Val Asp Phe Glu Glu Tyr Thr Ala Ser Val Leu 
        355                 360                 365             


Glu Arg Phe Ser Asn Pro Ala Ile Gln Asp Thr Val Ala Arg Ile Cys 
    370                 375                 380                 


Leu Met Gly Ser Gly Lys Met Pro Lys Tyr Val Leu Pro Ser Ile Tyr 
385                 390                 395                 400 


Glu Gln Leu Arg Lys Pro Asp Gly Lys Tyr Lys Leu Leu Ala Val Cys 
                405                 410                 415     


Val Ala Gly Trp Phe Arg Tyr Leu Thr Gly Val Asp Met Asn Gly Lys 
            420                 425                 430         


Pro Phe Glu Ile Glu Asp Pro Met Ala Pro Thr Leu Lys Ala Ala Ala 
        435                 440                 445             


Val Lys Gly Gly Lys Asp Pro His Glu Leu Leu Asn Ile Glu Val Leu 
    450                 455                 460                 


Phe Ser Pro Glu Ile Arg Asp Asn Lys Glu Phe Val Ala Gln Leu Thr 
465                 470                 475                 480 


His Ser Leu Glu Thr Val Tyr Asp Lys Gly Pro Ile Ala Ala Ile Lys 
                485                 490                 495     


Glu Ile Leu Asp Gln Val 
            500         


<210>  20
<211>  357
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  20

Met Ser Gln Asn Ser Asn Pro Ala Val Val Leu Glu Lys Val Gly Asp 
1               5                   10                  15      


Ile Ala Ile Glu Gln Arg Pro Ile Pro Thr Ile Lys Asp Pro His Tyr 
            20                  25                  30          


Val Lys Leu Ala Ile Lys Ala Thr Gly Ile Cys Gly Ser Asp Ile His 
        35                  40                  45              


Tyr Tyr Arg Ser Gly Gly Ile Gly Lys Tyr Ile Leu Lys Ala Pro Met 
    50                  55                  60                  


Val Leu Gly His Glu Ser Ser Gly Gln Val Val Glu Val Gly Asp Ala 
65                  70                  75                  80  


Val Thr Arg Val Lys Val Gly Asp Arg Val Ala Ile Glu Pro Gly Val 
                85                  90                  95      


Pro Ser Arg Tyr Ser Asp Glu Thr Lys Glu Gly Arg Tyr Asn Leu Cys 
            100                 105                 110         


Pro His Met Ala Phe Ala Ala Thr Pro Pro Ile Asp Gly Thr Leu Val 
        115                 120                 125             


Lys Tyr Tyr Leu Ser Pro Glu Asp Phe Leu Val Lys Leu Pro Glu Gly 
    130                 135                 140                 


Val Ser Tyr Glu Glu Gly Ala Cys Val Glu Pro Leu Ser Val Gly Val 
145                 150                 155                 160 


His Ser Asn Lys Leu Ala Gly Val Arg Phe Gly Thr Lys Val Val Val 
                165                 170                 175     


Phe Gly Ala Gly Pro Val Gly Leu Leu Thr Gly Ala Val Ala Arg Ala 
            180                 185                 190         


Phe Gly Ala Thr Asp Val Ile Phe Val Asp Val Phe Asp Asn Lys Leu 
        195                 200                 205             


Gln Arg Ala Lys Asp Phe Gly Ala Thr Asn Thr Phe Asn Ser Ser Gln 
    210                 215                 220                 


Phe Ser Thr Asp Lys Ala Gln Asp Leu Ala Asp Gly Val Gln Lys Leu 
225                 230                 235                 240 


Leu Gly Gly Asn His Ala Asp Val Val Phe Glu Cys Ser Gly Ala Asp 
                245                 250                 255     


Val Cys Ile Asp Ala Ala Val Lys Thr Thr Lys Val Gly Gly Thr Met 
            260                 265                 270         


Val Gln Val Gly Met Gly Lys Asn Tyr Thr Asn Phe Pro Ile Ala Glu 
        275                 280                 285             


Val Ser Gly Lys Glu Met Lys Leu Ile Gly Cys Phe Arg Tyr Ser Phe 
    290                 295                 300                 


Gly Asp Tyr Arg Asp Ala Val Asn Leu Val Ala Thr Gly Lys Val Asn 
305                 310                 315                 320 


Val Lys Pro Leu Ile Thr His Lys Phe Lys Phe Glu Asp Ala Ala Lys 
                325                 330                 335     


Ala Tyr Asp Tyr Asn Ile Ala His Gly Gly Glu Val Val Lys Thr Ile 
            340                 345                 350         


Ile Phe Gly Pro Glu 
        355         


<210>  21
<211>  357
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  21

Met Ser Gln Asn Ser Asn Pro Ala Val Val Leu Glu Lys Val Gly Asp 
1               5                   10                  15      


Ile Ala Ile Glu Gln Arg Pro Ile Pro Thr Ile Lys Asp Pro His Tyr 
            20                  25                  30          


Val Lys Leu Ala Ile Lys Ala Thr Gly Ile Cys Gly Ser Asp Ile His 
        35                  40                  45              


Tyr Tyr Arg Ser Gly Gly Ile Gly Lys Tyr Ile Leu Lys Ala Pro Met 
    50                  55                  60                  


Val Leu Gly His Glu Ser Ser Gly Gln Val Val Glu Val Gly Asp Ala 
65                  70                  75                  80  


Val Thr Arg Val Lys Val Gly Asp Arg Val Ala Ile Glu Pro Gly Val 
                85                  90                  95      


Pro Ser Arg Tyr Ser Asp Glu Thr Lys Glu Gly Ser Tyr Asn Leu Cys 
            100                 105                 110         


Pro His Met Ala Phe Ala Ala Thr Pro Pro Ile Asp Gly Thr Leu Val 
        115                 120                 125             


Lys Tyr Tyr Leu Ser Pro Glu Asp Phe Leu Val Lys Leu Pro Glu Gly 
    130                 135                 140                 


Val Ser Tyr Glu Glu Gly Ala Cys Val Glu Pro Leu Ser Val Gly Val 
145                 150                 155                 160 


His Ser Asn Lys Leu Ala Gly Val Arg Phe Gly Thr Lys Val Val Val 
                165                 170                 175     


Phe Gly Ala Gly Pro Val Gly Leu Leu Thr Gly Ala Val Ala Arg Ala 
            180                 185                 190         


Phe Gly Ala Thr Asp Val Ile Phe Val Asp Val Phe Asp Asn Lys Leu 
        195                 200                 205             


Gln Arg Ala Lys Asp Phe Gly Ala Thr Asn Thr Phe Asn Ser Ser Gln 
    210                 215                 220                 


Phe Ser Thr Asp Lys Ala Gln Asp Leu Ala Asp Gly Val Gln Lys Leu 
225                 230                 235                 240 


Leu Gly Gly Asn His Ala Asp Val Val Phe Glu Cys Ser Gly Ala Asp 
                245                 250                 255     


Val Cys Ile Asp Ala Ala Val Lys Thr Thr Lys Val Gly Gly Thr Met 
            260                 265                 270         


Val Gln Val Gly Met Gly Lys Asn Tyr Thr Asn Phe Pro Ile Ala Glu 
        275                 280                 285             


Val Ser Gly Lys Glu Met Lys Leu Ile Gly Cys Phe Arg Tyr Ser Phe 
    290                 295                 300                 


Gly Asp Tyr Arg Asp Ala Val Asn Leu Val Ala Thr Gly Lys Val Asn 
305                 310                 315                 320 


Val Lys Pro Leu Ile Thr His Lys Phe Lys Phe Glu Asp Ala Ala Lys 
                325                 330                 335     


Ala Tyr Asp Tyr Asn Ile Ala His Gly Gly Glu Val Val Lys Thr Ile 
            340                 345                 350         


Ile Phe Gly Pro Glu 
        355         


<210>  22
<211>  332
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  22

Met Ile Arg Ile Ala Ile Asn Gly Phe Gly Arg Ile Gly Arg Leu Val 
1               5                   10                  15      


Leu Arg Leu Ala Leu Gln Arg Lys Asp Ile Glu Val Val Ala Val Asn 
            20                  25                  30          


Asp Pro Phe Ile Ser Asn Asp Tyr Ala Ala Tyr Met Val Lys Tyr Asp 
        35                  40                  45              


Ser Thr His Gly Arg Tyr Lys Gly Thr Val Ser His Asp Asp Lys His 
    50                  55                  60                  


Ile Ile Ile Asp Gly Val Lys Ile Ala Thr Tyr Gln Glu Arg Asp Pro 
65                  70                  75                  80  


Ala Asn Leu Pro Trp Gly Ser Leu Lys Ile Asp Val Ala Val Asp Ser 
                85                  90                  95      


Thr Gly Val Phe Lys Glu Leu Asp Thr Ala Gln Lys His Ile Asp Ala 
            100                 105                 110         


Gly Ala Lys Lys Val Val Ile Thr Ala Pro Ser Ser Ser Ala Pro Met 
        115                 120                 125             


Phe Val Val Gly Val Asn His Thr Lys Tyr Thr Pro Asp Lys Lys Ile 
    130                 135                 140                 


Val Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu Ala Lys 
145                 150                 155                 160 


Val Ile Asn Asp Ala Phe Gly Ile Glu Glu Gly Leu Met Thr Thr Val 
                165                 170                 175     


His Ser Met Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser His Lys 
            180                 185                 190         


Asp Trp Arg Gly Gly Arg Thr Ala Ser Gly Asn Ile Ile Pro Ser Ser 
        195                 200                 205             


Thr Gly Ala Ala Lys Ala Val Gly Lys Val Leu Pro Glu Leu Gln Gly 
    210                 215                 220                 


Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Val Asp Val Ser Val 
225                 230                 235                 240 


Val Asp Leu Thr Val Lys Leu Glu Lys Glu Ala Thr Tyr Asp Gln Ile 
                245                 250                 255     


Lys Lys Ala Val Lys Ala Ala Ala Glu Gly Pro Met Lys Gly Val Leu 
            260                 265                 270         


Gly Tyr Thr Glu Asp Ala Val Val Ser Ser Asp Phe Leu Gly Asp Thr 
        275                 280                 285             


His Ala Ser Ile Phe Asp Ala Ser Ala Gly Ile Gln Leu Ser Pro Lys 
    290                 295                 300                 


Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Tyr Gly Tyr Ser Ala 
305                 310                 315                 320 


Arg Val Val Asp Leu Ile Glu Tyr Val Ala Lys Ala 
                325                 330         


<210>  23
<211>  332
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  23

Met Val Arg Val Ala Ile Asn Gly Phe Gly Arg Ile Gly Arg Leu Val 
1               5                   10                  15      


Met Arg Ile Ala Leu Gln Arg Lys Asn Val Glu Val Val Ala Leu Asn 
            20                  25                  30          


Asp Pro Phe Ile Ser Asn Asp Tyr Ser Ala Tyr Met Phe Lys Tyr Asp 
        35                  40                  45              


Ser Thr His Gly Arg Tyr Ala Gly Glu Val Ser His Asp Asp Lys His 
    50                  55                  60                  


Ile Ile Val Asp Gly His Lys Ile Ala Thr Phe Gln Glu Arg Asp Pro 
65                  70                  75                  80  


Ala Asn Leu Pro Trp Ala Ser Leu Asn Ile Asp Ile Ala Ile Asp Ser 
                85                  90                  95      


Thr Gly Val Phe Lys Glu Leu Asp Thr Ala Gln Lys His Ile Asp Ala 
            100                 105                 110         


Gly Ala Lys Lys Val Val Ile Thr Ala Pro Ser Ser Thr Ala Pro Met 
        115                 120                 125             


Phe Val Met Gly Val Asn Glu Glu Lys Tyr Thr Ser Asp Leu Lys Ile 
    130                 135                 140                 


Val Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu Ala Lys 
145                 150                 155                 160 


Val Ile Asn Asp Ala Phe Gly Ile Glu Glu Gly Leu Met Thr Thr Val 
                165                 170                 175     


His Ser Met Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser His Lys 
            180                 185                 190         


Asp Trp Arg Gly Gly Arg Thr Ala Ser Gly Asn Ile Ile Pro Ser Ser 
        195                 200                 205             


Thr Gly Ala Ala Lys Ala Val Gly Lys Val Leu Pro Glu Leu Gln Gly 
    210                 215                 220                 


Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Val Asp Val Ser Val 
225                 230                 235                 240 


Val Asp Leu Thr Val Lys Leu Asn Lys Glu Thr Thr Tyr Asp Glu Ile 
                245                 250                 255     


Lys Lys Val Val Lys Ala Ala Ala Glu Gly Lys Leu Lys Gly Val Leu 
            260                 265                 270         


Gly Tyr Thr Glu Asp Ala Val Val Ser Ser Asp Phe Leu Gly Asp Ser 
        275                 280                 285             


Asn Ser Ser Ile Phe Asp Ala Ala Ala Gly Ile Gln Leu Ser Pro Lys 
    290                 295                 300                 


Phe Val Lys Leu Val Ser Trp Tyr Asp Asn Glu Tyr Gly Tyr Ser Thr 
305                 310                 315                 320 


Arg Val Val Asp Leu Val Glu His Val Ala Lys Ala 
                325                 330         


<210>  24
<211>  332
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  24

Met Val Arg Val Ala Ile Asn Gly Phe Gly Arg Ile Gly Arg Leu Val 
1               5                   10                  15      


Met Arg Ile Ala Leu Ser Arg Pro Asn Val Glu Val Val Ala Leu Asn 
            20                  25                  30          


Asp Pro Phe Ile Thr Asn Asp Tyr Ala Ala Tyr Met Phe Lys Tyr Asp 
        35                  40                  45              


Ser Thr His Gly Arg Tyr Ala Gly Glu Val Ser His Asp Asp Lys His 
    50                  55                  60                  


Ile Ile Val Asp Gly Lys Lys Ile Ala Thr Tyr Gln Glu Arg Asp Pro 
65                  70                  75                  80  


Ala Asn Leu Pro Trp Gly Ser Ser Asn Val Asp Ile Ala Ile Asp Ser 
                85                  90                  95      


Thr Gly Val Phe Lys Glu Leu Asp Thr Ala Gln Lys His Ile Asp Ala 
            100                 105                 110         


Gly Ala Lys Lys Val Val Ile Thr Ala Pro Ser Ser Thr Ala Pro Met 
        115                 120                 125             


Phe Val Met Gly Val Asn Glu Glu Lys Tyr Thr Ser Asp Leu Lys Ile 
    130                 135                 140                 


Val Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu Ala Lys 
145                 150                 155                 160 


Val Ile Asn Asp Ala Phe Gly Ile Glu Glu Gly Leu Met Thr Thr Val 
                165                 170                 175     


His Ser Leu Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser His Lys 
            180                 185                 190         


Asp Trp Arg Gly Gly Arg Thr Ala Ser Gly Asn Ile Ile Pro Ser Ser 
        195                 200                 205             


Thr Gly Ala Ala Lys Ala Val Gly Lys Val Leu Pro Glu Leu Gln Gly 
    210                 215                 220                 


Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Val Asp Val Ser Val 
225                 230                 235                 240 


Val Asp Leu Thr Val Lys Leu Asn Lys Glu Thr Thr Tyr Asp Glu Ile 
                245                 250                 255     


Lys Lys Val Val Lys Ala Ala Ala Glu Gly Lys Leu Lys Gly Val Leu 
            260                 265                 270         


Gly Tyr Thr Glu Asp Ala Val Val Ser Ser Asp Phe Leu Gly Asp Ser 
        275                 280                 285             


His Ser Ser Ile Phe Asp Ala Ser Ala Gly Ile Gln Leu Ser Pro Lys 
    290                 295                 300                 


Phe Val Lys Leu Val Ser Trp Tyr Asp Asn Glu Tyr Gly Tyr Ser Thr 
305                 310                 315                 320 


Arg Val Val Asp Leu Val Glu His Val Ala Lys Ala 
                325                 330         


<210>  25
<211>  1710
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  25
atgaaggatt taaaattatc gaatttcaaa ggcaaattta taagcagaac cagtcactgg       60

ggacttacgg gtaagaagtt gcggtatttc atcactatcg catctatgac gggcttctcc      120

ctgtttggat acgaccaagg gttgatggca agtctaatta ctggtaaaca gttcaactat      180

gaatttccag caaccaaaga aaatggcgat catgacagac acgcaactgt agtgcagggc      240

gctacaacct cctgttatga attaggttgt ttcgcaggtt ctctattcgt tatgttctgc      300

ggtgaaagaa ttggtagaaa accattaatc ctgatgggtt ccgtaataac catcattggt      360

gccgttattt ctacatgcgc atttcgtggt tactgggcat taggccagtt tatcatcgga      420

agagtcgtca ctggtgttgg aacagggttg aatacatcta ctattcccgt ttggcaatca      480

gaaatgtcaa aagctgaaaa tagagggttg ctggtcaatt tagaaggttc cacaattgct      540

tttggtacta tgattgctta ttggattgat tttgggttgt cttataccaa cagttctgtt      600

cagtggagat tccccgtgtc aatgcaaatc gtttttgctc tcttcctgct tgctttcatg      660

attaaactac ctgaatcgcc acgttggctg atttctcaaa gtcgaacaga agaagctcgc      720

tacttggtag gaacactaga cgacgcggat ccaaatgatg aggaagttat aacagaagtt      780

gctatgcttc acgatgctgt taacaggacc aaacacgaga aacattcact gtcaagtttg      840

ttctccagag gcaggtccca aaatcttcag agggctttga ttgcagcttc aacgcaattt      900

ttccagcaat ttactggttg taacgctgcc atatactact ctactgtatt attcaacaaa      960

acaattaaat tagactatag attatcaatg atcataggtg gggtcttcgc aacaatctac     1020

gccttatcta ctattggttc attttttcta attgaaaagc taggtagacg taagctgttt     1080

ttattaggtg ccacaggtca agcagtttca ttcacaatta catttgcatg cttggtcaaa     1140

gaaaataaag aaaacgcaag aggtgctgcc gtcggcttat ttttgttcat tacattcttt     1200

ggtttgtctt tgctatcatt accatggata tacccaccag aaattgcatc aatgaaagtt     1260

cgtgcatcaa caaacgcttt ctccacatgt actaattggt tgtgtaactt tgcggttgtc     1320

atgttcaccc caatatttat tggacagtcc ggttggggtt gctacttatt ttttgctgtt     1380

atgaattatt tatacattcc agttatcttc tttttctacc ctgaaaccgc cggaagaagt     1440

ttggaggaaa tcgacatcat ctttgctaaa gcatacgagg atggcactca accatggaga     1500

gttgctaacc atttgcccaa gttatcccta caagaagtcg aagatcatgc caatgcattg     1560

ggctcttatg acgacgaaat ggaaaaagag gactttggtg aagatagagt agaagacacc     1620

tataaccaaa ttaacggcga taattcgtct agttcttcaa acatcaaaaa tgaagataca     1680

gtgaacgata aagcaaattt tgagggttga                                      1710


<210>  26
<211>  569
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  26

Met Lys Asp Leu Lys Leu Ser Asn Phe Lys Gly Lys Phe Ile Ser Arg 
1               5                   10                  15      


Thr Ser His Trp Gly Leu Thr Gly Lys Lys Leu Arg Tyr Phe Ile Thr 
            20                  25                  30          


Ile Ala Ser Met Thr Gly Phe Ser Leu Phe Gly Tyr Asp Gln Gly Leu 
        35                  40                  45              


Met Ala Ser Leu Ile Thr Gly Lys Gln Phe Asn Tyr Glu Phe Pro Ala 
    50                  55                  60                  


Thr Lys Glu Asn Gly Asp His Asp Arg His Ala Thr Val Val Gln Gly 
65                  70                  75                  80  


Ala Thr Thr Ser Cys Tyr Glu Leu Gly Cys Phe Ala Gly Ser Leu Phe 
                85                  90                  95      


Val Met Phe Cys Gly Glu Arg Ile Gly Arg Lys Pro Leu Ile Leu Met 
            100                 105                 110         


Gly Ser Val Ile Thr Ile Ile Gly Ala Val Ile Ser Thr Cys Ala Phe 
        115                 120                 125             


Arg Gly Tyr Trp Ala Leu Gly Gln Phe Ile Ile Gly Arg Val Val Thr 
    130                 135                 140                 


Gly Val Gly Thr Gly Leu Asn Thr Ser Thr Ile Pro Val Trp Gln Ser 
145                 150                 155                 160 


Glu Met Ser Lys Ala Glu Asn Arg Gly Leu Leu Val Asn Leu Glu Gly 
                165                 170                 175     


Ser Thr Ile Ala Phe Gly Thr Met Ile Ala Tyr Trp Ile Asp Phe Gly 
            180                 185                 190         


Leu Ser Tyr Thr Asn Ser Ser Val Gln Trp Arg Phe Pro Val Ser Met 
        195                 200                 205             


Gln Ile Val Phe Ala Leu Phe Leu Leu Ala Phe Met Ile Lys Leu Pro 
    210                 215                 220                 


Glu Ser Pro Arg Trp Leu Ile Ser Gln Ser Arg Thr Glu Glu Ala Arg 
225                 230                 235                 240 


Tyr Leu Val Gly Thr Leu Asp Asp Ala Asp Pro Asn Asp Glu Glu Val 
                245                 250                 255     


Ile Thr Glu Val Ala Met Leu His Asp Ala Val Asn Arg Thr Lys His 
            260                 265                 270         


Glu Lys His Ser Leu Ser Ser Leu Phe Ser Arg Gly Arg Ser Gln Asn 
        275                 280                 285             


Leu Gln Arg Ala Leu Ile Ala Ala Ser Thr Gln Phe Phe Gln Gln Phe 
    290                 295                 300                 


Thr Gly Cys Asn Ala Ala Ile Tyr Tyr Ser Thr Val Leu Phe Asn Lys 
305                 310                 315                 320 


Thr Ile Lys Leu Asp Tyr Arg Leu Ser Met Ile Ile Gly Gly Val Phe 
                325                 330                 335     


Ala Thr Ile Tyr Ala Leu Ser Thr Ile Gly Ser Phe Phe Leu Ile Glu 
            340                 345                 350         


Lys Leu Gly Arg Arg Lys Leu Phe Leu Leu Gly Ala Thr Gly Gln Ala 
        355                 360                 365             


Val Ser Phe Thr Ile Thr Phe Ala Cys Leu Val Lys Glu Asn Lys Glu 
    370                 375                 380                 


Asn Ala Arg Gly Ala Ala Val Gly Leu Phe Leu Phe Ile Thr Phe Phe 
385                 390                 395                 400 


Gly Leu Ser Leu Leu Ser Leu Pro Trp Ile Tyr Pro Pro Glu Ile Ala 
                405                 410                 415     


Ser Met Lys Val Arg Ala Ser Thr Asn Ala Phe Ser Thr Cys Thr Asn 
            420                 425                 430         


Trp Leu Cys Asn Phe Ala Val Val Met Phe Thr Pro Ile Phe Ile Gly 
        435                 440                 445             


Gln Ser Gly Trp Gly Cys Tyr Leu Phe Phe Ala Val Met Asn Tyr Leu 
    450                 455                 460                 


Tyr Ile Pro Val Ile Phe Phe Phe Tyr Pro Glu Thr Ala Gly Arg Ser 
465                 470                 475                 480 


Leu Glu Glu Ile Asp Ile Ile Phe Ala Lys Ala Tyr Glu Asp Gly Thr 
                485                 490                 495     


Gln Pro Trp Arg Val Ala Asn His Leu Pro Lys Leu Ser Leu Gln Glu 
            500                 505                 510         


Val Glu Asp His Ala Asn Ala Leu Gly Ser Tyr Asp Asp Glu Met Glu 
        515                 520                 525             


Lys Glu Asp Phe Gly Glu Asp Arg Val Glu Asp Thr Tyr Asn Gln Ile 
    530                 535                 540                 


Asn Gly Asp Asn Ser Ser Ser Ser Ser Asn Ile Lys Asn Glu Asp Thr 
545                 550                 555                 560 


Val Asn Asp Lys Ala Asn Phe Glu Gly 
                565                 


<210>  27
<211>  1527
<212>  DNA
<213>  Saccharomycopsis fibuligera

<400>  27
atgaggttcc catctatttt caccgctgtt ttgtttgctg cttcttctgc tttggctaac       60

accggtcatt tccaagctta ttctggttat accgttaaca gagctaactt cacccaatgg      120

attcatgaac aaccagctgt ttcttggtac tacttgttgc aaaacatcga ttacccagaa      180

ggtcaattca aagctgctaa accaggtgtt gttgttgctt ctccatctac atctgaacca      240

gattacttct accaatggac tagagatacc gctattacct tcttgtcctt gattgctgaa      300

gttgaagatc attctttctc caacactacc ttggctaagg ttgtcgaata ttacatttcc      360

aacacctaca ccttgcaaag agtttctaat ccatccggta acttcgattc tccaaatcat      420

gatggtttgg gtgaacctaa gttcaacgtt gatgatactg cttatacagc ttcttggggt      480

agaccacaaa atgatggtcc agctttgaga gcttacgcta tttctagata cttgaacgct      540

gttgctaagc acaacaacgg taaattatta ttggccggtc aaaacggtat tccttattct      600

tctgcttccg atatctactg gaagattatt aagccagact tgcaacatgt ttctactcat      660

tggtctacct ctggttttga tttgtgggaa gaaaatcaag gtactcattt cttcaccgct      720

ttggttcaat tgaaggcttt gtcttacggt attccattgt ctaagaccta caatgatcca      780

ggtttcactt cttggttgga aaaacaaaag gatgccttga actcctacat taactcttcc      840

ggtttcgtta actctggtaa aaagcacatc gttgaatctc cacaattgtc atctagaggt      900

ggtttggatt ctgctactta tattgctgcc ttgatcaccc atgatatcgg tgatgatgat      960

acttacaccc cattcaatgt tgataactcc tacgttttga actccttgta ttacctattg     1020

gtcgacaaca agaacagata caagatcaac ggtaactaca aagctggtgc tgctgttggt     1080

agatatcctg aagatgttta caacggtgtt ggtacttctg aaggtaatcc atggcaattg     1140

gctactgctt atgctggtca aactttttac accttggcct acaattcctt gaagaacaag     1200

aagaacttgg tcatcgaaaa gttgaactac gacttgtaca actccttcat tgctgatttg     1260

tccaagattg attcttccta cgcttctaag gattctttga ctttgaccta cggttccgat     1320

aactacaaga acgttatcaa gtccttgttg caattcggtg actcattctt gaaggttttg     1380

ttggatcaca tcgatgacaa cggtcaattg actgaagaaa tcaacagata caccggtttt     1440

caagctggtg cagtttcttt gacttggtca tctggttctt tgttgtctgc taatagagcc     1500

agaaacaagt tgatcgaatt attgtga                                         1527


<210>  28
<211>  508
<212>  PRT
<213>  Saccharomycopsis fibuligera

<400>  28

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Asn Thr Gly His Phe Gln Ala Tyr Ser Gly Tyr Thr Val 
            20                  25                  30          


Asn Arg Ala Asn Phe Thr Gln Trp Ile His Glu Gln Pro Ala Val Ser 
        35                  40                  45              


Trp Tyr Tyr Leu Leu Gln Asn Ile Asp Tyr Pro Glu Gly Gln Phe Lys 
    50                  55                  60                  


Ala Ala Lys Pro Gly Val Val Val Ala Ser Pro Ser Thr Ser Glu Pro 
65                  70                  75                  80  


Asp Tyr Phe Tyr Gln Trp Thr Arg Asp Thr Ala Ile Thr Phe Leu Ser 
                85                  90                  95      


Leu Ile Ala Glu Val Glu Asp His Ser Phe Ser Asn Thr Thr Leu Ala 
            100                 105                 110         


Lys Val Val Glu Tyr Tyr Ile Ser Asn Thr Tyr Thr Leu Gln Arg Val 
        115                 120                 125             


Ser Asn Pro Ser Gly Asn Phe Asp Ser Pro Asn His Asp Gly Leu Gly 
    130                 135                 140                 


Glu Pro Lys Phe Asn Val Asp Asp Thr Ala Tyr Thr Ala Ser Trp Gly 
145                 150                 155                 160 


Arg Pro Gln Asn Asp Gly Pro Ala Leu Arg Ala Tyr Ala Ile Ser Arg 
                165                 170                 175     


Tyr Leu Asn Ala Val Ala Lys His Asn Asn Gly Lys Leu Leu Leu Ala 
            180                 185                 190         


Gly Gln Asn Gly Ile Pro Tyr Ser Ser Ala Ser Asp Ile Tyr Trp Lys 
        195                 200                 205             


Ile Ile Lys Pro Asp Leu Gln His Val Ser Thr His Trp Ser Thr Ser 
    210                 215                 220                 


Gly Phe Asp Leu Trp Glu Glu Asn Gln Gly Thr His Phe Phe Thr Ala 
225                 230                 235                 240 


Leu Val Gln Leu Lys Ala Leu Ser Tyr Gly Ile Pro Leu Ser Lys Thr 
                245                 250                 255     


Tyr Asn Asp Pro Gly Phe Thr Ser Trp Leu Glu Lys Gln Lys Asp Ala 
            260                 265                 270         


Leu Asn Ser Tyr Ile Asn Ser Ser Gly Phe Val Asn Ser Gly Lys Lys 
        275                 280                 285             


His Ile Val Glu Ser Pro Gln Leu Ser Ser Arg Gly Gly Leu Asp Ser 
    290                 295                 300                 


Ala Thr Tyr Ile Ala Ala Leu Ile Thr His Asp Ile Gly Asp Asp Asp 
305                 310                 315                 320 


Thr Tyr Thr Pro Phe Asn Val Asp Asn Ser Tyr Val Leu Asn Ser Leu 
                325                 330                 335     


Tyr Tyr Leu Leu Val Asp Asn Lys Asn Arg Tyr Lys Ile Asn Gly Asn 
            340                 345                 350         


Tyr Lys Ala Gly Ala Ala Val Gly Arg Tyr Pro Glu Asp Val Tyr Asn 
        355                 360                 365             


Gly Val Gly Thr Ser Glu Gly Asn Pro Trp Gln Leu Ala Thr Ala Tyr 
    370                 375                 380                 


Ala Gly Gln Thr Phe Tyr Thr Leu Ala Tyr Asn Ser Leu Lys Asn Lys 
385                 390                 395                 400 


Lys Asn Leu Val Ile Glu Lys Leu Asn Tyr Asp Leu Tyr Asn Ser Phe 
                405                 410                 415     


Ile Ala Asp Leu Ser Lys Ile Asp Ser Ser Tyr Ala Ser Lys Asp Ser 
            420                 425                 430         


Leu Thr Leu Thr Tyr Gly Ser Asp Asn Tyr Lys Asn Val Ile Lys Ser 
        435                 440                 445             


Leu Leu Gln Phe Gly Asp Ser Phe Leu Lys Val Leu Leu Asp His Ile 
    450                 455                 460                 


Asp Asp Asn Gly Gln Leu Thr Glu Glu Ile Asn Arg Tyr Thr Gly Phe 
465                 470                 475                 480 


Gln Ala Gly Ala Val Ser Leu Thr Trp Ser Ser Gly Ser Leu Leu Ser 
                485                 490                 495     


Ala Asn Arg Ala Arg Asn Lys Leu Ile Glu Leu Leu 
            500                 505             


<210>  29
<211>  915
<212>  DNA
<213>  Clostridium butyricum

<400>  29
atgtccaaag aaatcaaggg cgtcttgttc aatatccaaa agttctcatt gcatgacggt       60

ccaggtatta gaactatcgt ttttttcaag ggctgctcca tgtcttgttt gtggtgttct      120

aatccagaaa gccaagagat taagccacaa gtcatgttca acaagaactt gtgtactaag      180

tgtggtaggt gtaagtctga atgtaaatcc gctgctatcg atatgaactc cgagtacaga      240

attgataagt ctaagtgtac cgaatgcacc aagtgtgttg ataactgttt gtctggtgct      300

ttggttactg aaggtagaaa ctactctgtt gaggacgtca tcaaagaatt gaagaaggat      360

tccgttcagt acagacgttc taatggtggt attactttat ccggtggtga agttttgttg      420

caaccagatt ttgccgttga gttgttgaaa gaatgcaaat cttatggttg gcataccgct      480

attgaaaccg ctatgtatgt taactccgaa tccgttaaga aggtcatccc ttatattgat      540

ttggccatga tcgacatcaa gtccatgaat gacgaaatcc acaaaaagtt caccggtgtc      600

tctaacgaaa tcatcttgca aaacatcaag ctgtccgatg aattggccaa agagattatt      660

atcagaatcc cagtcatcga aggtttcaat gctgacttgc aatctattgg tgctattgcc      720

caattctcta agtctttgac taacttgaag aggatcgact tgttgccata ccataattac      780

ggtgaaaaca agtaccaagc catcggtaga gaatactcat tgaaagagtt gaagtctccc      840

tcaaaggaca agatggaaag attgaaagcc ttggttgaaa tcatgggtat tccatgtaca      900

attggtgccg aatga                                                       915


<210>  30
<211>  304
<212>  PRT
<213>  Clostridium butyricum

<400>  30

Met Ser Lys Glu Ile Lys Gly Val Leu Phe Asn Ile Gln Lys Phe Ser 
1               5                   10                  15      


Leu His Asp Gly Pro Gly Ile Arg Thr Ile Val Phe Phe Lys Gly Cys 
            20                  25                  30          


Ser Met Ser Cys Leu Trp Cys Ser Asn Pro Glu Ser Gln Glu Ile Lys 
        35                  40                  45              


Pro Gln Val Met Phe Asn Lys Asn Leu Cys Thr Lys Cys Gly Arg Cys 
    50                  55                  60                  


Lys Ser Glu Cys Lys Ser Ala Ala Ile Asp Met Asn Ser Glu Tyr Arg 
65                  70                  75                  80  


Ile Asp Lys Ser Lys Cys Thr Glu Cys Thr Lys Cys Val Asp Asn Cys 
                85                  90                  95      


Leu Ser Gly Ala Leu Val Thr Glu Gly Arg Asn Tyr Ser Val Glu Asp 
            100                 105                 110         


Val Ile Lys Glu Leu Lys Lys Asp Ser Val Gln Tyr Arg Arg Ser Asn 
        115                 120                 125             


Gly Gly Ile Thr Leu Ser Gly Gly Glu Val Leu Leu Gln Pro Asp Phe 
    130                 135                 140                 


Ala Val Glu Leu Leu Lys Glu Cys Lys Ser Tyr Gly Trp His Thr Ala 
145                 150                 155                 160 


Ile Glu Thr Ala Met Tyr Val Asn Ser Glu Ser Val Lys Lys Val Ile 
                165                 170                 175     


Pro Tyr Ile Asp Leu Ala Met Ile Asp Ile Lys Ser Met Asn Asp Glu 
            180                 185                 190         


Ile His Lys Lys Phe Thr Gly Val Ser Asn Glu Ile Ile Leu Gln Asn 
        195                 200                 205             


Ile Lys Leu Ser Asp Glu Leu Ala Lys Glu Ile Ile Ile Arg Ile Pro 
    210                 215                 220                 


Val Ile Glu Gly Phe Asn Ala Asp Leu Gln Ser Ile Gly Ala Ile Ala 
225                 230                 235                 240 


Gln Phe Ser Lys Ser Leu Thr Asn Leu Lys Arg Ile Asp Leu Leu Pro 
                245                 250                 255     


Tyr His Asn Tyr Gly Glu Asn Lys Tyr Gln Ala Ile Gly Arg Glu Tyr 
            260                 265                 270         


Ser Leu Lys Glu Leu Lys Ser Pro Ser Lys Asp Lys Met Glu Arg Leu 
        275                 280                 285             


Lys Ala Leu Val Glu Ile Met Gly Ile Pro Cys Thr Ile Gly Ala Glu 
    290                 295                 300                 


<210>  31
<211>  2364
<212>  DNA
<213>  Clostridium butyricum

<400>  31
atgatctcca agggtttctc tactcaaacc gaaagaatca acattttgaa ggcccaaatt       60

ttgaacgcta agccatgtgt tgaatccgaa agagctattt tgatcaccga atctttcaag      120

caaactgaag gtcaaccagc aattttgaga agggctttag ccttgaaaca catcttggaa      180

aacattccaa tcaccatcag ggaccaagaa ttgatagttg gttctttgac aaaagagccc      240

agatcctctc aagtttttcc agaattttct aacaagtggt tgcaggacga attggacaga      300

ttgaacaaaa gaactggtga tgccttccag atctccgaag aatctaaaga aaagctgaag      360

gacgttttcg aatactggaa tggtaagact acttctgaat tggctacttc ctacatgact      420

gaagaaacta gagaagccgt taactgtgat gttttcactg ttggtaacta ctactacaac      480

ggtgttggtc atgtttctgt tgattacggt aaggttttga gagttggttt caacggtatt      540

atcaacgaag ccaaagaaca gttggaaaag tccagatcta ttgacccaga cttcatcaag      600

aaagagaagt tcttgaactc cgtcatcatt tcttgtgaag ctgctattac ctacgttaac      660

agatacgcta aaaaggccaa agaaattgcc gataacactt ccgatgctaa gagaaaagca      720

gaattgaacg aaattgccaa gatctgctct aaggtttctg gtgaaggtgc caaatctttt      780

tatgaagctt gtcagttgtt ctggttcatc catgccatta tcaacatcga atctaacggt      840

cattctatct ctccagctag atttgaccag tatatgtacc cttactacga gaacgataag      900

aacatcactg ataagttcgc ccaagagttg attgattgca tttggatcaa gctgaacgac      960

atcaacaaag ttagggacga aatttctact aagcactttg gtggttaccc aatgtaccaa     1020

aatttgatcg ttggtggtca aaactccgaa ggtaaagatg ctacaaacaa ggtttcttac     1080

atggctttgg aagctgctgt tcatgttaag ttgccacaac catctttgtc cgttagaatt     1140

tggaacaaga ctccagacga attcttgtta agagctgctg aattgacaag agaaggtttg     1200

ggtttgccag cttactacaa tgatgaagtt attatcccag ccttggtgtc tagaggtttg     1260

actttagaag atgctagaga ctacggtatc attggttgtg ttgaaccaca aaaaccaggt     1320

aagactgaag gttggcatga ttccgctttt ttcaatttgg ctagaatcgt cgaactgacc     1380

attaactctg gttttgacaa gaacaagcaa atcggtccaa agactcagaa cttcgaagaa     1440

atgaagtcct tcgacgaatt catgaaggct tacaaagctc agatggaata cttcgttaag     1500

cacatgtgtt gtgccgataa ctgcattgat attgctcatg ctgaaagagc accattgcca     1560

tttttatcct ctatggttga taactgtatc ggcaaaggta aatccttgca agatggtggt     1620

gctgagtaca atttttctgg tcctcaaggt gttggtgttg ctaatattgg tgattcttta     1680

gttgccgtca aaaagatcgt ctttgacgaa aacaagatca ccccatccga attgaagaaa     1740

accttgaaca acgacttcaa gaacagcgaa gaaattcaag ccttgttgaa gaatgctcca     1800

aagttcggta acgatatcga tgaagttgat aatttggcca gagaaggtgc tttggtttac     1860

tgtagagaag ttaacaagta cactaaccca agaggtggta attttcaacc aggtctatat     1920

ccctcctcca tcaatgttta tttcggttct ttaactggtg ctaccccaga tggtagaaaa     1980

tctggtcaac cattggctga tggtgtttct ccatcaagag gttgtgatgt tagtggtcca     2040

actgctgctt gtaattctgt ttctaagctg gatcatttca ttgcttccaa cggcaccttg     2100

tttaatcaaa agtttcatcc atctgccttg aagggtgata atggtttgat gaacttgtcc     2160

tccttgatca gatcttactt cgatcaaaag ggtttccacg tccaattcaa cgtcattgat     2220

aagaagattt tgttggctgc ccaaaagaac cctgaaaagt atcaagattt gattgtcaga     2280

gttgctggtt actccgctca gtttatttca ttggataagt ccatccagaa cgacattatt     2340

gctagaaccg aacacgttat gtaa                                            2364


<210>  32
<211>  787
<212>  PRT
<213>  Clostridium butyricum

<400>  32

Met Ile Ser Lys Gly Phe Ser Thr Gln Thr Glu Arg Ile Asn Ile Leu 
1               5                   10                  15      


Lys Ala Gln Ile Leu Asn Ala Lys Pro Cys Val Glu Ser Glu Arg Ala 
            20                  25                  30          


Ile Leu Ile Thr Glu Ser Phe Lys Gln Thr Glu Gly Gln Pro Ala Ile 
        35                  40                  45              


Leu Arg Arg Ala Leu Ala Leu Lys His Ile Leu Glu Asn Ile Pro Ile 
    50                  55                  60                  


Thr Ile Arg Asp Gln Glu Leu Ile Val Gly Ser Leu Thr Lys Glu Pro 
65                  70                  75                  80  


Arg Ser Ser Gln Val Phe Pro Glu Phe Ser Asn Lys Trp Leu Gln Asp 
                85                  90                  95      


Glu Leu Asp Arg Leu Asn Lys Arg Thr Gly Asp Ala Phe Gln Ile Ser 
            100                 105                 110         


Glu Glu Ser Lys Glu Lys Leu Lys Asp Val Phe Glu Tyr Trp Asn Gly 
        115                 120                 125             


Lys Thr Thr Ser Glu Leu Ala Thr Ser Tyr Met Thr Glu Glu Thr Arg 
    130                 135                 140                 


Glu Ala Val Asn Cys Asp Val Phe Thr Val Gly Asn Tyr Tyr Tyr Asn 
145                 150                 155                 160 


Gly Val Gly His Val Ser Val Asp Tyr Gly Lys Val Leu Arg Val Gly 
                165                 170                 175     


Phe Asn Gly Ile Ile Asn Glu Ala Lys Glu Gln Leu Glu Lys Ser Arg 
            180                 185                 190         


Ser Ile Asp Pro Asp Phe Ile Lys Lys Glu Lys Phe Leu Asn Ser Val 
        195                 200                 205             


Ile Ile Ser Cys Glu Ala Ala Ile Thr Tyr Val Asn Arg Tyr Ala Lys 
    210                 215                 220                 


Lys Ala Lys Glu Ile Ala Asp Asn Thr Ser Asp Ala Lys Arg Lys Ala 
225                 230                 235                 240 


Glu Leu Asn Glu Ile Ala Lys Ile Cys Ser Lys Val Ser Gly Glu Gly 
                245                 250                 255     


Ala Lys Ser Phe Tyr Glu Ala Cys Gln Leu Phe Trp Phe Ile His Ala 
            260                 265                 270         


Ile Ile Asn Ile Glu Ser Asn Gly His Ser Ile Ser Pro Ala Arg Phe 
        275                 280                 285             


Asp Gln Tyr Met Tyr Pro Tyr Tyr Glu Asn Asp Lys Asn Ile Thr Asp 
    290                 295                 300                 


Lys Phe Ala Gln Glu Leu Ile Asp Cys Ile Trp Ile Lys Leu Asn Asp 
305                 310                 315                 320 


Ile Asn Lys Val Arg Asp Glu Ile Ser Thr Lys His Phe Gly Gly Tyr 
                325                 330                 335     


Pro Met Tyr Gln Asn Leu Ile Val Gly Gly Gln Asn Ser Glu Gly Lys 
            340                 345                 350         


Asp Ala Thr Asn Lys Val Ser Tyr Met Ala Leu Glu Ala Ala Val His 
        355                 360                 365             


Val Lys Leu Pro Gln Pro Ser Leu Ser Val Arg Ile Trp Asn Lys Thr 
    370                 375                 380                 


Pro Asp Glu Phe Leu Leu Arg Ala Ala Glu Leu Thr Arg Glu Gly Leu 
385                 390                 395                 400 


Gly Leu Pro Ala Tyr Tyr Asn Asp Glu Val Ile Ile Pro Ala Leu Val 
                405                 410                 415     


Ser Arg Gly Leu Thr Leu Glu Asp Ala Arg Asp Tyr Gly Ile Ile Gly 
            420                 425                 430         


Cys Val Glu Pro Gln Lys Pro Gly Lys Thr Glu Gly Trp His Asp Ser 
        435                 440                 445             


Ala Phe Phe Asn Leu Ala Arg Ile Val Glu Leu Thr Ile Asn Ser Gly 
    450                 455                 460                 


Phe Asp Lys Asn Lys Gln Ile Gly Pro Lys Thr Gln Asn Phe Glu Glu 
465                 470                 475                 480 


Met Lys Ser Phe Asp Glu Phe Met Lys Ala Tyr Lys Ala Gln Met Glu 
                485                 490                 495     


Tyr Phe Val Lys His Met Cys Cys Ala Asp Asn Cys Ile Asp Ile Ala 
            500                 505                 510         


His Ala Glu Arg Ala Pro Leu Pro Phe Leu Ser Ser Met Val Asp Asn 
        515                 520                 525             


Cys Ile Gly Lys Gly Lys Ser Leu Gln Asp Gly Gly Ala Glu Tyr Asn 
    530                 535                 540                 


Phe Ser Gly Pro Gln Gly Val Gly Val Ala Asn Ile Gly Asp Ser Leu 
545                 550                 555                 560 


Val Ala Val Lys Lys Ile Val Phe Asp Glu Asn Lys Ile Thr Pro Ser 
                565                 570                 575     


Glu Leu Lys Lys Thr Leu Asn Asn Asp Phe Lys Asn Ser Glu Glu Ile 
            580                 585                 590         


Gln Ala Leu Leu Lys Asn Ala Pro Lys Phe Gly Asn Asp Ile Asp Glu 
        595                 600                 605             


Val Asp Asn Leu Ala Arg Glu Gly Ala Leu Val Tyr Cys Arg Glu Val 
    610                 615                 620                 


Asn Lys Tyr Thr Asn Pro Arg Gly Gly Asn Phe Gln Pro Gly Leu Tyr 
625                 630                 635                 640 


Pro Ser Ser Ile Asn Val Tyr Phe Gly Ser Leu Thr Gly Ala Thr Pro 
                645                 650                 655     


Asp Gly Arg Lys Ser Gly Gln Pro Leu Ala Asp Gly Val Ser Pro Ser 
            660                 665                 670         


Arg Gly Cys Asp Val Ser Gly Pro Thr Ala Ala Cys Asn Ser Val Ser 
        675                 680                 685             


Lys Leu Asp His Phe Ile Ala Ser Asn Gly Thr Leu Phe Asn Gln Lys 
    690                 695                 700                 


Phe His Pro Ser Ala Leu Lys Gly Asp Asn Gly Leu Met Asn Leu Ser 
705                 710                 715                 720 


Ser Leu Ile Arg Ser Tyr Phe Asp Gln Lys Gly Phe His Val Gln Phe 
                725                 730                 735     


Asn Val Ile Asp Lys Lys Ile Leu Leu Ala Ala Gln Lys Asn Pro Glu 
            740                 745                 750         


Lys Tyr Gln Asp Leu Ile Val Arg Val Ala Gly Tyr Ser Ala Gln Phe 
        755                 760                 765             


Ile Ser Leu Asp Lys Ser Ile Gln Asn Asp Ile Ile Ala Arg Thr Glu 
    770                 775                 780                 


His Val Met 
785         


<210>  33
<211>  1158
<212>  DNA
<213>  Clostridium butyricum

<400>  33
atgaggatgt acgattattt ggtcccatcc gttaatttca tgggtgctaa ttctgtttcc       60

gttgttggtg aaagatgcaa gattttaggt ggtaagaagg ctttgatcgt taccgataag      120

ttcttgaagg atatggaagg tggtgctgtt gaattgactg tgaagtattt gaaagaagcc      180

ggtttggacg ttgtttacta tgatggtgtt gaacctaatc caaaggatgt caacgttatc      240

gaaggcctga agattttcaa agaagaaaac tgcgatatga tcgtcactgt tggtggtggt      300

tcttctcatg attgtggtaa aggtattggt attgctgcta ctcatgaagg tgacttgtat      360

gattatgctg gtatcgaaac tttggtcaat ccattgccac caatagttgc tgttaacact      420

actgctggta ctgcttctga attgacaaga cattgtgttt tgaccaacac caagaagaag      480

atcaagttcg ttatcgtgtc ttggagaaac ttgccattgg tttctattaa cgacccaatg      540

ttgatggtta agaaaccagc aggtttgact gctgctacag gtatggatgc tttgactcat      600

gctattgaag cttacgtttc taaggatgct aacccagtta ctgatgcttc tgctattcaa      660

gccattaagt tgatctccca aaacttgaga caagctgttg ctttgggtga aaatttggaa      720

gctcgtgaga atatggctta cgcttctttg ttggctggta tggcttttaa caatgctaac      780

ttgggttacg ttcatgctat ggctcatcaa ttaggtggtc tatatgatat ggcacatggt      840

gttgctaatg ctatgttgtt gccacatgtt gaaaggtaca acatgatctc taacccaaag      900

aagttcgctg atattgctga gtttatgggt gagaacattt ccggtttgtc tgttatggaa      960

gctgctgaaa aagctattaa cgccatgttc agattgtccg aagatgttgg tattcccaag     1020

tccttgaaag aaatgggtgt taagcaagag gatttcgaac atatggctga attggctttg     1080

ttagatggta acgctttctc caatccaaga aagggtaatg ccaaggatat cattaacatt     1140

ttcaaggccg cttactaa                                                   1158


<210>  34
<211>  385
<212>  PRT
<213>  Clostridium butyricum

<400>  34

Met Arg Met Tyr Asp Tyr Leu Val Pro Ser Val Asn Phe Met Gly Ala 
1               5                   10                  15      


Asn Ser Val Ser Val Val Gly Glu Arg Cys Lys Ile Leu Gly Gly Lys 
            20                  25                  30          


Lys Ala Leu Ile Val Thr Asp Lys Phe Leu Lys Asp Met Glu Gly Gly 
        35                  40                  45              


Ala Val Glu Leu Thr Val Lys Tyr Leu Lys Glu Ala Gly Leu Asp Val 
    50                  55                  60                  


Val Tyr Tyr Asp Gly Val Glu Pro Asn Pro Lys Asp Val Asn Val Ile 
65                  70                  75                  80  


Glu Gly Leu Lys Ile Phe Lys Glu Glu Asn Cys Asp Met Ile Val Thr 
                85                  90                  95      


Val Gly Gly Gly Ser Ser His Asp Cys Gly Lys Gly Ile Gly Ile Ala 
            100                 105                 110         


Ala Thr His Glu Gly Asp Leu Tyr Asp Tyr Ala Gly Ile Glu Thr Leu 
        115                 120                 125             


Val Asn Pro Leu Pro Pro Ile Val Ala Val Asn Thr Thr Ala Gly Thr 
    130                 135                 140                 


Ala Ser Glu Leu Thr Arg His Cys Val Leu Thr Asn Thr Lys Lys Lys 
145                 150                 155                 160 


Ile Lys Phe Val Ile Val Ser Trp Arg Asn Leu Pro Leu Val Ser Ile 
                165                 170                 175     


Asn Asp Pro Met Leu Met Val Lys Lys Pro Ala Gly Leu Thr Ala Ala 
            180                 185                 190         


Thr Gly Met Asp Ala Leu Thr His Ala Ile Glu Ala Tyr Val Ser Lys 
        195                 200                 205             


Asp Ala Asn Pro Val Thr Asp Ala Ser Ala Ile Gln Ala Ile Lys Leu 
    210                 215                 220                 


Ile Ser Gln Asn Leu Arg Gln Ala Val Ala Leu Gly Glu Asn Leu Glu 
225                 230                 235                 240 


Ala Arg Glu Asn Met Ala Tyr Ala Ser Leu Leu Ala Gly Met Ala Phe 
                245                 250                 255     


Asn Asn Ala Asn Leu Gly Tyr Val His Ala Met Ala His Gln Leu Gly 
            260                 265                 270         


Gly Leu Tyr Asp Met Ala His Gly Val Ala Asn Ala Met Leu Leu Pro 
        275                 280                 285             


His Val Glu Arg Tyr Asn Met Ile Ser Asn Pro Lys Lys Phe Ala Asp 
    290                 295                 300                 


Ile Ala Glu Phe Met Gly Glu Asn Ile Ser Gly Leu Ser Val Met Glu 
305                 310                 315                 320 


Ala Ala Glu Lys Ala Ile Asn Ala Met Phe Arg Leu Ser Glu Asp Val 
                325                 330                 335     


Gly Ile Pro Lys Ser Leu Lys Glu Met Gly Val Lys Gln Glu Asp Phe 
            340                 345                 350         


Glu His Met Ala Glu Leu Ala Leu Leu Asp Gly Asn Ala Phe Ser Asn 
        355                 360                 365             


Pro Arg Lys Gly Asn Ala Lys Asp Ile Ile Asn Ile Phe Lys Ala Ala 
    370                 375                 380                 


Tyr 
385 


<210>  35
<211>  2733
<212>  DNA
<213>  Bifidobacterium adolescentis

<400>  35
atggccgacg ccaagaagaa agaagaacct actaagccaa ccccagaaga aaaattggct       60

gctgctgaag ctgaagttga tgctttggtt aagaaaggtt tgaaggcctt ggacgaattc      120

gaaaaattgg atcaaaagca agtcgatcac atcgttgcta aagcttcagt tgctgctttg      180

aacaaacatt tggttttggc taagatggcc gttgaagaaa ctcatagagg tttggttgaa      240

gataaggcca ccaagaatat tttcgcttgt gaacatgtca ccaactattt ggctggtcaa      300

aagaccgttg gtatcattag agaagatgat gttttgggta tcgacgaaat tgctgaacca      360

gttggtgttg ttgctggtgt tactccagtt actaatccaa cttctaccgc tattttcaag      420

tccttgattg ccttgaaaac cagatgccca attatctttg gttttcatcc aggtgctcaa      480

aactgttctg ttgctgctgc taaaatcgtt agagatgctg ctattgctgc tggtgctcca      540

gaaaactgta ttcaatggat tgaacaccca tccattgaag ctactggtgc tttgatgaag      600

cacgatggtg ttgctactat tttggctact ggtggtccag gtatggttaa ggctgcttat      660

tcttctggta aaccagcttt gggtgttggt gctggtaatg ctccagctta tgttgataag      720

aacgttgatg ttgttagagc tgccaacgat ttgattttgt ctaagcactt cgactacggt      780

atgatttgtg ctactgaaca agctattatc gccgataagg atatctatgc tccattggtc      840

aaagaattga agagaagaaa ggcctacttc gttaatgctg acgaaaaagc taagttggaa      900

cagtatatgt tcggttgtac cgcttactct ggtcaaactc caaagttgaa ttctgttgtt      960

ccaggtaagt ccccacagta tattgctaaa gctgccggtt tcgaaattcc agaagatgct     1020

acaattttgg ccgctgaatg taaagaagtc ggagaaaacg aaccattgac catggaaaaa     1080

ttggcaccag ttcaagctgt tttgaagtcc gataacaaag aacaagcctt cgaaatgtgc     1140

gaagccatgt tgaaacatgg tgctggtcat actgctgcta ttcatacaaa cgatagagac     1200

ttggtcagag aatacggtca aagaatgcat gcctgcagaa ttatttggaa ctctccatct     1260

tctttgggtg gtgttggtga tatctacaat gctattgctc catctttgac tttgggttgt     1320

ggttcttatg gtggtaattc tgtttccggt aatgttcaag ccgtcaactt gattaacatc     1380

aagagaatcg ctagaagaaa caacaacatg caatggttca agattccagc taagacttac     1440

tttgaaccta acgccatcaa gtacctaaga gatatgtacg gtatcgaaaa ggctgttatc     1500

gtttgcgata aggtcatgga acaattgggt atcgttgata agatcatcga tcaattgaga     1560

gccagatcta acagagttac cttcagaatc atcgattacg ttgaaccaga accatctgtt     1620

gaaacagttg aaaggggtgc tgctatgatg agagaagaat ttgaacctga taccattatt     1680

gctgttggtg gtggttctcc aatggatgct tctaagatta tgtggttgtt gtacgaacac     1740

ccagaaattt cattctccga tgtcagagaa aagttcttcg acattagaaa gagagccttt     1800

aagattccac cattgggtaa aaaggccaag ttggtatgta ttccaacctc ttcaggtact     1860

ggttctgaag ttactccatt cgctgttatt accgatcata agactggtta caagtaccca     1920

attaccgatt atgctttgac tccatctgtt gctatcgttg atccagtttt ggctagaact     1980

caacctagaa aattggcttc tgatgctggt tttgatgctt tgacacatgc ttttgaagcc     2040

tacgtttctg tttacgctaa cgatttcact gatggtatgg ctttacatgc tgctaaattg     2100

gtttgggata acttggctga atccgttaat ggtgaaccag gtgaagaaaa aactagagcc     2160

caagaaaaga tgcataacgc tgctactatg gctggtatgg catttggttc tgcttttttg     2220

ggtatgtgtc atggtatggc tcatacaatt ggtgctttgt gtcatgttgc tcatggtaga     2280

actaactcca ttttgttgcc atacgtcatc agatacaacg gttctgttcc tgaagaacct     2340

acatcttggc caaagtacaa caagtatatt gccccagaaa gataccaaga aatcgctaag     2400

aacttgggtg ttaatccagg taaaactcct gaagaaggtg ttgaaaattt ggctaaggct     2460

gtcgaagatt acagagataa caagttgggt atgaacaagt ccttccaaga atgtggtgtt     2520

gacgaagatt actactggtc cattatcgat caaattggta tgagagccta cgaagatcaa     2580

tgtgctccag ctaatccaag aattccacaa atcgaagata tgaaggatat tgctattgcc     2640

gcttactacg gtgtttctca agctgaaggt cataagttga gagttcaaag acaaggtgaa     2700

gctgctacag aagaagcttc tgaaagagct taa                                  2733


<210>  36
<211>  910
<212>  PRT
<213>  Bifidobacterium adolescentis

<400>  36

Met Ala Asp Ala Lys Lys Lys Glu Glu Pro Thr Lys Pro Thr Pro Glu 
1               5                   10                  15      


Glu Lys Leu Ala Ala Ala Glu Ala Glu Val Asp Ala Leu Val Lys Lys 
            20                  25                  30          


Gly Leu Lys Ala Leu Asp Glu Phe Glu Lys Leu Asp Gln Lys Gln Val 
        35                  40                  45              


Asp His Ile Val Ala Lys Ala Ser Val Ala Ala Leu Asn Lys His Leu 
    50                  55                  60                  


Val Leu Ala Lys Met Ala Val Glu Glu Thr His Arg Gly Leu Val Glu 
65                  70                  75                  80  


Asp Lys Ala Thr Lys Asn Ile Phe Ala Cys Glu His Val Thr Asn Tyr 
                85                  90                  95      


Leu Ala Gly Gln Lys Thr Val Gly Ile Ile Arg Glu Asp Asp Val Leu 
            100                 105                 110         


Gly Ile Asp Glu Ile Ala Glu Pro Val Gly Val Val Ala Gly Val Thr 
        115                 120                 125             


Pro Val Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Ser Leu Ile Ala 
    130                 135                 140                 


Leu Lys Thr Arg Cys Pro Ile Ile Phe Gly Phe His Pro Gly Ala Gln 
145                 150                 155                 160 


Asn Cys Ser Val Ala Ala Ala Lys Ile Val Arg Asp Ala Ala Ile Ala 
                165                 170                 175     


Ala Gly Ala Pro Glu Asn Cys Ile Gln Trp Ile Glu His Pro Ser Ile 
            180                 185                 190         


Glu Ala Thr Gly Ala Leu Met Lys His Asp Gly Val Ala Thr Ile Leu 
        195                 200                 205             


Ala Thr Gly Gly Pro Gly Met Val Lys Ala Ala Tyr Ser Ser Gly Lys 
    210                 215                 220                 


Pro Ala Leu Gly Val Gly Ala Gly Asn Ala Pro Ala Tyr Val Asp Lys 
225                 230                 235                 240 


Asn Val Asp Val Val Arg Ala Ala Asn Asp Leu Ile Leu Ser Lys His 
                245                 250                 255     


Phe Asp Tyr Gly Met Ile Cys Ala Thr Glu Gln Ala Ile Ile Ala Asp 
            260                 265                 270         


Lys Asp Ile Tyr Ala Pro Leu Val Lys Glu Leu Lys Arg Arg Lys Ala 
        275                 280                 285             


Tyr Phe Val Asn Ala Asp Glu Lys Ala Lys Leu Glu Gln Tyr Met Phe 
    290                 295                 300                 


Gly Cys Thr Ala Tyr Ser Gly Gln Thr Pro Lys Leu Asn Ser Val Val 
305                 310                 315                 320 


Pro Gly Lys Ser Pro Gln Tyr Ile Ala Lys Ala Ala Gly Phe Glu Ile 
                325                 330                 335     


Pro Glu Asp Ala Thr Ile Leu Ala Ala Glu Cys Lys Glu Val Gly Glu 
            340                 345                 350         


Asn Glu Pro Leu Thr Met Glu Lys Leu Ala Pro Val Gln Ala Val Leu 
        355                 360                 365             


Lys Ser Asp Asn Lys Glu Gln Ala Phe Glu Met Cys Glu Ala Met Leu 
    370                 375                 380                 


Lys His Gly Ala Gly His Thr Ala Ala Ile His Thr Asn Asp Arg Asp 
385                 390                 395                 400 


Leu Val Arg Glu Tyr Gly Gln Arg Met His Ala Cys Arg Ile Ile Trp 
                405                 410                 415     


Asn Ser Pro Ser Ser Leu Gly Gly Val Gly Asp Ile Tyr Asn Ala Ile 
            420                 425                 430         


Ala Pro Ser Leu Thr Leu Gly Cys Gly Ser Tyr Gly Gly Asn Ser Val 
        435                 440                 445             


Ser Gly Asn Val Gln Ala Val Asn Leu Ile Asn Ile Lys Arg Ile Ala 
    450                 455                 460                 


Arg Arg Asn Asn Asn Met Gln Trp Phe Lys Ile Pro Ala Lys Thr Tyr 
465                 470                 475                 480 


Phe Glu Pro Asn Ala Ile Lys Tyr Leu Arg Asp Met Tyr Gly Ile Glu 
                485                 490                 495     


Lys Ala Val Ile Val Cys Asp Lys Val Met Glu Gln Leu Gly Ile Val 
            500                 505                 510         


Asp Lys Ile Ile Asp Gln Leu Arg Ala Arg Ser Asn Arg Val Thr Phe 
        515                 520                 525             


Arg Ile Ile Asp Tyr Val Glu Pro Glu Pro Ser Val Glu Thr Val Glu 
    530                 535                 540                 


Arg Gly Ala Ala Met Met Arg Glu Glu Phe Glu Pro Asp Thr Ile Ile 
545                 550                 555                 560 


Ala Val Gly Gly Gly Ser Pro Met Asp Ala Ser Lys Ile Met Trp Leu 
                565                 570                 575     


Leu Tyr Glu His Pro Glu Ile Ser Phe Ser Asp Val Arg Glu Lys Phe 
            580                 585                 590         


Phe Asp Ile Arg Lys Arg Ala Phe Lys Ile Pro Pro Leu Gly Lys Lys 
        595                 600                 605             


Ala Lys Leu Val Cys Ile Pro Thr Ser Ser Gly Thr Gly Ser Glu Val 
    610                 615                 620                 


Thr Pro Phe Ala Val Ile Thr Asp His Lys Thr Gly Tyr Lys Tyr Pro 
625                 630                 635                 640 


Ile Thr Asp Tyr Ala Leu Thr Pro Ser Val Ala Ile Val Asp Pro Val 
                645                 650                 655     


Leu Ala Arg Thr Gln Pro Arg Lys Leu Ala Ser Asp Ala Gly Phe Asp 
            660                 665                 670         


Ala Leu Thr His Ala Phe Glu Ala Tyr Val Ser Val Tyr Ala Asn Asp 
        675                 680                 685             


Phe Thr Asp Gly Met Ala Leu His Ala Ala Lys Leu Val Trp Asp Asn 
    690                 695                 700                 


Leu Ala Glu Ser Val Asn Gly Glu Pro Gly Glu Glu Lys Thr Arg Ala 
705                 710                 715                 720 


Gln Glu Lys Met His Asn Ala Ala Thr Met Ala Gly Met Ala Phe Gly 
                725                 730                 735     


Ser Ala Phe Leu Gly Met Cys His Gly Met Ala His Thr Ile Gly Ala 
            740                 745                 750         


Leu Cys His Val Ala His Gly Arg Thr Asn Ser Ile Leu Leu Pro Tyr 
        755                 760                 765             


Val Ile Arg Tyr Asn Gly Ser Val Pro Glu Glu Pro Thr Ser Trp Pro 
    770                 775                 780                 


Lys Tyr Asn Lys Tyr Ile Ala Pro Glu Arg Tyr Gln Glu Ile Ala Lys 
785                 790                 795                 800 


Asn Leu Gly Val Asn Pro Gly Lys Thr Pro Glu Glu Gly Val Glu Asn 
                805                 810                 815     


Leu Ala Lys Ala Val Glu Asp Tyr Arg Asp Asn Lys Leu Gly Met Asn 
            820                 825                 830         


Lys Ser Phe Gln Glu Cys Gly Val Asp Glu Asp Tyr Tyr Trp Ser Ile 
        835                 840                 845             


Ile Asp Gln Ile Gly Met Arg Ala Tyr Glu Asp Gln Cys Ala Pro Ala 
    850                 855                 860                 


Asn Pro Arg Ile Pro Gln Ile Glu Asp Met Lys Asp Ile Ala Ile Ala 
865                 870                 875                 880 


Ala Tyr Tyr Gly Val Ser Gln Ala Glu Gly His Lys Leu Arg Val Gln 
                885                 890                 895     


Arg Gln Gly Glu Ala Ala Thr Glu Glu Ala Ser Glu Arg Ala 
            900                 905                 910 


<210>  37
<211>  2079
<212>  DNA
<213>  Neurospora crassa

<400>  37
atggtcagta gatttttggg tgctactgtt ccattggctg ctgctatttt gccaggtgct       60

agagcattat atgttaacgg ttctgttact gctccatgcg attctccaat ctactgttat      120

ggtgaattat tgcaccaagt cgaattggct agaccattct ctgattctaa gacctttgtt      180

gatatgccaa ccatcaagcc agttgatgaa gttttggaag ctttctctaa gttgaccttg      240

ccattgtcta acaactccga attgcatgaa ttcttgtcta cttactttgg tccagctggt      300

ggtgaattgg aagctgttcc aactgatcaa ttgcatgttt ctccaacttt cttggacaac      360

gtttccgatg atgttatcaa gcaattcgtt gactccgtta ttaacatttg gccagatttg      420

accagaaagt atgttggtgc cggtgaattg tgtactggtt gtgctgattc tttcatccca      480

gttaacagaa cttttgttgt tgctggtggt agattcagag aaccatatta ctgggattct      540

ttctggatct tggaaggttt gttgagaact ggtggtgctt tcactgaaat ctccaagaac      600

attatcgaaa actttttgga cttggtcgaa caaatcggtt ttgttccaaa tggtgctaga      660

ttgtactact tggatagatc tcaaccacca ttattgaccc aaatggttag aatctacgtt      720

gaacatacca acgacacctc cattttggaa agagctgttc ctgttttgaa gaaagaatgg      780

gaatggtgga ctaccaacag aactgttgaa gttactgctg atggtaagac ctactcattg      840

caaagatacc acgttgacaa caatcaacct agaccagaat cttacagaga agattacatt      900

accgccaaca acaactctta ctatgctacc tctggtatca tctacccaga aactactcca      960

ttgaacgata ctcaaaaggc tttgttgtac gctaatttgg cttctggtgc tgaatctggt     1020

tgggattatt cttctagatg gttgaagaat ccaggtgatg ctgctagaga tgtttacttt     1080

ccattgagat ccttgaacgt cttggaaatc gttccagttg atttgaactc catcttgtac     1140

caaaacgaag ttaccatcgg taagttcttg gctcaacaag gttctaaaga tgaagctgaa     1200

gaatgggcta aaaaggccga agaaagatct gaagctatgt acaagttgat gtggaactct     1260

actttgtggt cctacttcga ttacaacttg acctcttctt ctcaaaacat ctacgttcca     1320

gctgatccac aagtttttcc atttgaacaa ccatctggta ctccagaagg ttaccaagtt     1380

ttgttctccg tcaatcaaat gtttccattc tggactggtg ctgctccaga tcaattgaaa     1440

ggtaatccat tagctgttaa gttggccttc gaaagaatca agaacttgtt ggataacaag     1500

gccggtggta ttccagctac taattttgtt actggtcaac aatgggatga acctaatgtt     1560

tggccaccat tgatgcatgt tttgatggat ggtttattga acactccagc tacctttggt     1620

gaagatgatc cagcttatca agaaactcaa accttggctt tgagattggc tcaaagatac     1680

gttgattcta ctttctgtac ttggtatgct actggtggtt ctacttctga aactccaaaa     1740

ttgcaaggtt tgggttctga tttgaagggt atcatgttcg aaaagtactc cgataactct     1800

acaaacgttg ctggttcagg tggtgaatat gaagttgttg aaggttttgg ttggaccaac     1860

ggtgttttga tttgggctgc tgataagttt ggtgacaagt tgaaaagacc agattgcggt     1920

gatattactc cagctcaagt tggtaaaaga gccgatatta ctatggaaaa gagagccgtt     1980

gaattggacg tttttgatgc taagttcacc aagaagtttg ccagaaaggg taaattggaa     2040

aagttgaagg ccaagttcaa aagaagagct gccatttag                            2079


<210>  38
<211>  692
<212>  PRT
<213>  Neurospora crassa

<400>  38

Met Val Ser Arg Phe Leu Gly Ala Thr Val Pro Leu Ala Ala Ala Ile 
1               5                   10                  15      


Leu Pro Gly Ala Arg Ala Leu Tyr Val Asn Gly Ser Val Thr Ala Pro 
            20                  25                  30          


Cys Asp Ser Pro Ile Tyr Cys Tyr Gly Glu Leu Leu His Gln Val Glu 
        35                  40                  45              


Leu Ala Arg Pro Phe Ser Asp Ser Lys Thr Phe Val Asp Met Pro Thr 
    50                  55                  60                  


Ile Lys Pro Val Asp Glu Val Leu Glu Ala Phe Ser Lys Leu Thr Leu 
65                  70                  75                  80  


Pro Leu Ser Asn Asn Ser Glu Leu His Glu Phe Leu Ser Thr Tyr Phe 
                85                  90                  95      


Gly Pro Ala Gly Gly Glu Leu Glu Ala Val Pro Thr Asp Gln Leu His 
            100                 105                 110         


Val Ser Pro Thr Phe Leu Asp Asn Val Ser Asp Asp Val Ile Lys Gln 
        115                 120                 125             


Phe Val Asp Ser Val Ile Asn Ile Trp Pro Asp Leu Thr Arg Lys Tyr 
    130                 135                 140                 


Val Gly Ala Gly Glu Leu Cys Thr Gly Cys Ala Asp Ser Phe Ile Pro 
145                 150                 155                 160 


Val Asn Arg Thr Phe Val Val Ala Gly Gly Arg Phe Arg Glu Pro Tyr 
                165                 170                 175     


Tyr Trp Asp Ser Phe Trp Ile Leu Glu Gly Leu Leu Arg Thr Gly Gly 
            180                 185                 190         


Ala Phe Thr Glu Ile Ser Lys Asn Ile Ile Glu Asn Phe Leu Asp Leu 
        195                 200                 205             


Val Glu Gln Ile Gly Phe Val Pro Asn Gly Ala Arg Leu Tyr Tyr Leu 
    210                 215                 220                 


Asp Arg Ser Gln Pro Pro Leu Leu Thr Gln Met Val Arg Ile Tyr Val 
225                 230                 235                 240 


Glu His Thr Asn Asp Thr Ser Ile Leu Glu Arg Ala Val Pro Val Leu 
                245                 250                 255     


Lys Lys Glu Trp Glu Trp Trp Thr Thr Asn Arg Thr Val Glu Val Thr 
            260                 265                 270         


Ala Asp Gly Lys Thr Tyr Ser Leu Gln Arg Tyr His Val Asp Asn Asn 
        275                 280                 285             


Gln Pro Arg Pro Glu Ser Tyr Arg Glu Asp Tyr Ile Thr Ala Asn Asn 
    290                 295                 300                 


Asn Ser Tyr Tyr Ala Thr Ser Gly Ile Ile Tyr Pro Glu Thr Thr Pro 
305                 310                 315                 320 


Leu Asn Asp Thr Gln Lys Ala Leu Leu Tyr Ala Asn Leu Ala Ser Gly 
                325                 330                 335     


Ala Glu Ser Gly Trp Asp Tyr Ser Ser Arg Trp Leu Lys Asn Pro Gly 
            340                 345                 350         


Asp Ala Ala Arg Asp Val Tyr Phe Pro Leu Arg Ser Leu Asn Val Leu 
        355                 360                 365             


Glu Ile Val Pro Val Asp Leu Asn Ser Ile Leu Tyr Gln Asn Glu Val 
    370                 375                 380                 


Thr Ile Gly Lys Phe Leu Ala Gln Gln Gly Ser Lys Asp Glu Ala Glu 
385                 390                 395                 400 


Glu Trp Ala Lys Lys Ala Glu Glu Arg Ser Glu Ala Met Tyr Lys Leu 
                405                 410                 415     


Met Trp Asn Ser Thr Leu Trp Ser Tyr Phe Asp Tyr Asn Leu Thr Ser 
            420                 425                 430         


Ser Ser Gln Asn Ile Tyr Val Pro Ala Asp Pro Gln Val Phe Pro Phe 
        435                 440                 445             


Glu Gln Pro Ser Gly Thr Pro Glu Gly Tyr Gln Val Leu Phe Ser Val 
    450                 455                 460                 


Asn Gln Met Phe Pro Phe Trp Thr Gly Ala Ala Pro Asp Gln Leu Lys 
465                 470                 475                 480 


Gly Asn Pro Leu Ala Val Lys Leu Ala Phe Glu Arg Ile Lys Asn Leu 
                485                 490                 495     


Leu Asp Asn Lys Ala Gly Gly Ile Pro Ala Thr Asn Phe Val Thr Gly 
            500                 505                 510         


Gln Gln Trp Asp Glu Pro Asn Val Trp Pro Pro Leu Met His Val Leu 
        515                 520                 525             


Met Asp Gly Leu Leu Asn Thr Pro Ala Thr Phe Gly Glu Asp Asp Pro 
    530                 535                 540                 


Ala Tyr Gln Glu Thr Gln Thr Leu Ala Leu Arg Leu Ala Gln Arg Tyr 
545                 550                 555                 560 


Val Asp Ser Thr Phe Cys Thr Trp Tyr Ala Thr Gly Gly Ser Thr Ser 
                565                 570                 575     


Glu Thr Pro Lys Leu Gln Gly Leu Gly Ser Asp Leu Lys Gly Ile Met 
            580                 585                 590         


Phe Glu Lys Tyr Ser Asp Asn Ser Thr Asn Val Ala Gly Ser Gly Gly 
        595                 600                 605             


Glu Tyr Glu Val Val Glu Gly Phe Gly Trp Thr Asn Gly Val Leu Ile 
    610                 615                 620                 


Trp Ala Ala Asp Lys Phe Gly Asp Lys Leu Lys Arg Pro Asp Cys Gly 
625                 630                 635                 640 


Asp Ile Thr Pro Ala Gln Val Gly Lys Arg Ala Asp Ile Thr Met Glu 
                645                 650                 655     


Lys Arg Ala Val Glu Leu Asp Val Phe Asp Ala Lys Phe Thr Lys Lys 
            660                 665                 670         


Phe Ala Arg Lys Gly Lys Leu Glu Lys Leu Lys Ala Lys Phe Lys Arg 
        675                 680                 685             


Arg Ala Ala Ile 
    690         


<210>  39
<211>  1548
<212>  DNA
<213>  Saccharomycopsis fibuligera

<400>  39
atgatcagat tgaccgtttt cttgaccgct gtttttgctg ctgttgcttc ttgtgttcca       60

gttgaattgg ataagagaaa caccggtcat ttccaagctt attctggtta taccgttaac      120

agatctaact tcacccaatg gattcatgaa caaccagctg tttcttggta ctacttgttg      180

caaaacatcg attacccaga aggtcaattc aaatctgcta aaccaggtgt tgttgttgct      240

tctccatcta catctgaacc agattacttc taccaatgga ctagagatac cgctattacc      300

ttcttgtcct tgattgctga agttgaagat cattctttct ccaacactac cttggctaag      360

gttgtcgaat attacatttc caacacctac accttgcaaa gagtttctaa tccatccggt      420

aacttcgatt ctccaaatca tgatggtttg ggtgaaccta agttcaacgt tgatgatact      480

gcttatacag cttcttgggg tagaccacaa aatgatggtc cagctttgag agcttacgct      540

atttctagat acttgaacgc tgttgctaag cacaacaacg gtaaattatt attggccggt      600

caaaacggta ttccttattc ttctgcttcc gatatctact ggaagattat taagccagac      660

ttgcaacatg tttctactca ttggtctacc tctggttttg atttgtggga agaaaatcaa      720

ggtactcatt tcttcaccgc tttggttcaa ttgaaggctt tgtcttacgg tattccattg      780

tctaagacct acaatgatcc aggtttcact tcttggttgg aaaaacaaaa ggatgccttg      840

aactcctaca ttaactcttc cggtttcgtt aactctggta aaaagcacat cgttgaatct      900

ccacaattgt catctagagg tggtttggat tctgctactt atattgctgc cttgatcacc      960

catgatatcg gtgatgatga tacttacacc ccattcaatg ttgataactc ctacgttttg     1020

aactccttgt attacctatt ggtcgacaac aagaacagat acaagatcaa cggtaactac     1080

aaagctggtg ctgctgttgg tagatatcct gaagatgttt acaacggtgt tggtacttct     1140

gaaggtaatc catggcaatt ggctactgct tatgctggtc aaacttttta caccttggcc     1200

tacaattcct tgaagaacaa gaagaacttg gtcatcgaaa agttgaacta cgacttgtac     1260

aactccttca ttgctgattt gtccaagatt gattcttcct acgcttctaa ggattctttg     1320

actttgacct acggttccga taactacaag aacgttatca agtccttgtt gcaattcggt     1380

gactcattct tgaaggtttt gttggatcac atcgatgaca acggtcaatt gactgaagaa     1440

atcaacagat acaccggttt tcaagctggt gcagtttctt tgacttggtc atctggttct     1500

ttgttgtctg ctaatagagc cagaaacaag ttgatcgaat tattgtga                  1548


<210>  40
<211>  1548
<212>  DNA
<213>  Saccharomycopsis fibuligera

<400>  40
atgatcagat tgaccgtttt cttgaccgct gtttttgctg ctgttgcttc ttgtgttcca       60

gttgaattgg ataagagaaa caccggtcat ttccaagctt attctggtta taccgttgct      120

agatctaact tcacccaatg gattcatgaa caaccagctg tttcttggta ctacttgttg      180

caaaacatcg attacccaga aggtcaattc aaatctgcta aaccaggtgt tgttgttgct      240

tctccatcta catctgaacc agattacttc taccaatgga ctagagatac cgctattacc      300

ttcttgtcct tgattgctga agttgaagat cattctttct ccaacactac cttggctaag      360

gttgtcgaat attacatttc caacacctac accttgcaaa gagtttctaa tccatccggt      420

aacttcgatt ctccaaatca tgatggtttg ggtgaaccta agttcaacgt tgatgatact      480

gcttatacag cttcttgggg tagaccacaa aatgatggtc cagctttgag agcttacgct      540

atttctagat acttgaacgc tgttgctaag cacaacaacg gtaaattatt attggccggt      600

caaaacggta ttccttattc ttctgcttcc gatatctact ggaagattat taagccagac      660

ttgcaacatg tttctactca ttggtctacc tctggttttg atttgtggga agaaaatcaa      720

ggtactcatt tcttcaccgc tttggttcaa ttgaaggctt tgtcttacgg tattccattg      780

tctaagacct acaatgatcc aggtttcact tcttggttgg aaaaacaaaa ggatgccttg      840

aactcctaca ttaactcttc cggtttcgtt aactctggta aaaagcacat cgttgaatct      900

ccacaattgt catctagagg tggtttggat tctgctactt atattgctgc cttgatcacc      960

catgatatcg gtgatgatga tacttacacc ccattcaatg ttgataactc ctacgttttg     1020

aactccttgt attacctatt ggtcgacaac aagaacagat acaagatcaa cggtaactac     1080

aaagctggtg ctgctgttgg tagatatcct gaagatgttt acaacggtgt tggtacttct     1140

gaaggtaatc catggcaatt ggctactgct tatgctggtc aaacttttta caccttggcc     1200

tacaattcct tgaagaacaa gaagaacttg gtcatcgaaa agttgaacta cgacttgtac     1260

aactccttca ttgctgattt gtccaagatt gattcttcct acgcttctaa ggattctttg     1320

actttgacct acggttccga taactacaag aacgttatca agtccttgtt gcaattcggt     1380

gactcattct tgaaggtttt gttggatcac atcgatgaca acggtcaatt gactgaagaa     1440

atcaacagat acaccggttt tcaagctggt gcagtttctt tgacttggtc atctggttct     1500

ttgttgtctg ctaatagagc cagaaacaag ttgatcgaat tattgtga                  1548


<210>  41
<211>  515
<212>  PRT
<213>  Saccharomycopsis fibuligera

<400>  41

Met Ile Arg Leu Thr Val Phe Leu Thr Ala Val Phe Ala Ala Val Ala 
1               5                   10                  15      


Ser Cys Val Pro Val Glu Leu Asp Lys Arg Asn Thr Gly His Phe Gln 
            20                  25                  30          


Ala Tyr Ser Gly Tyr Thr Val Ala Arg Ser Asn Phe Thr Gln Trp Ile 
        35                  40                  45              


His Glu Gln Pro Ala Val Ser Trp Tyr Tyr Leu Leu Gln Asn Ile Asp 
    50                  55                  60                  


Tyr Pro Glu Gly Gln Phe Lys Ser Ala Lys Pro Gly Val Val Val Ala 
65                  70                  75                  80  


Ser Pro Ser Thr Ser Glu Pro Asp Tyr Phe Tyr Gln Trp Thr Arg Asp 
                85                  90                  95      


Thr Ala Ile Thr Phe Leu Ser Leu Ile Ala Glu Val Glu Asp His Ser 
            100                 105                 110         


Phe Ser Asn Thr Thr Leu Ala Lys Val Val Glu Tyr Tyr Ile Ser Asn 
        115                 120                 125             


Thr Tyr Thr Leu Gln Arg Val Ser Asn Pro Ser Gly Asn Phe Asp Ser 
    130                 135                 140                 


Pro Asn His Asp Gly Leu Gly Glu Pro Lys Phe Asn Val Asp Asp Thr 
145                 150                 155                 160 


Ala Tyr Thr Ala Ser Trp Gly Arg Pro Gln Asn Asp Gly Pro Ala Leu 
                165                 170                 175     


Arg Ala Tyr Ala Ile Ser Arg Tyr Leu Asn Ala Val Ala Lys His Asn 
            180                 185                 190         


Asn Gly Lys Leu Leu Leu Ala Gly Gln Asn Gly Ile Pro Tyr Ser Ser 
        195                 200                 205             


Ala Ser Asp Ile Tyr Trp Lys Ile Ile Lys Pro Asp Leu Gln His Val 
    210                 215                 220                 


Ser Thr His Trp Ser Thr Ser Gly Phe Asp Leu Trp Glu Glu Asn Gln 
225                 230                 235                 240 


Gly Thr His Phe Phe Thr Ala Leu Val Gln Leu Lys Ala Leu Ser Tyr 
                245                 250                 255     


Gly Ile Pro Leu Ser Lys Thr Tyr Asn Asp Pro Gly Phe Thr Ser Trp 
            260                 265                 270         


Leu Glu Lys Gln Lys Asp Ala Leu Asn Ser Tyr Ile Asn Ser Ser Gly 
        275                 280                 285             


Phe Val Asn Ser Gly Lys Lys His Ile Val Glu Ser Pro Gln Leu Ser 
    290                 295                 300                 


Ser Arg Gly Gly Leu Asp Ser Ala Thr Tyr Ile Ala Ala Leu Ile Thr 
305                 310                 315                 320 


His Asp Ile Gly Asp Asp Asp Thr Tyr Thr Pro Phe Asn Val Asp Asn 
                325                 330                 335     


Ser Tyr Val Leu Asn Ser Leu Tyr Tyr Leu Leu Val Asp Asn Lys Asn 
            340                 345                 350         


Arg Tyr Lys Ile Asn Gly Asn Tyr Lys Ala Gly Ala Ala Val Gly Arg 
        355                 360                 365             


Tyr Pro Glu Asp Val Tyr Asn Gly Val Gly Thr Ser Glu Gly Asn Pro 
    370                 375                 380                 


Trp Gln Leu Ala Thr Ala Tyr Ala Gly Gln Thr Phe Tyr Thr Leu Ala 
385                 390                 395                 400 


Tyr Asn Ser Leu Lys Asn Lys Lys Asn Leu Val Ile Glu Lys Leu Asn 
                405                 410                 415     


Tyr Asp Leu Tyr Asn Ser Phe Ile Ala Asp Leu Ser Lys Ile Asp Ser 
            420                 425                 430         


Ser Tyr Ala Ser Lys Asp Ser Leu Thr Leu Thr Tyr Gly Ser Asp Asn 
        435                 440                 445             


Tyr Lys Asn Val Ile Lys Ser Leu Leu Gln Phe Gly Asp Ser Phe Leu 
    450                 455                 460                 


Lys Val Leu Leu Asp His Ile Asp Asp Asn Gly Gln Leu Thr Glu Glu 
465                 470                 475                 480 


Ile Asn Arg Tyr Thr Gly Phe Gln Ala Gly Ala Val Ser Leu Thr Trp 
                485                 490                 495     


Ser Ser Gly Ser Leu Leu Ser Ala Asn Arg Ala Arg Asn Lys Leu Ile 
            500                 505                 510         


Glu Leu Leu 
        515 


<210>  42
<211>  6438
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  42
atgccagtgt tgaaatcaga caatttcgat ccattggaag aagcttacga aggtgggaca       60

attcaaaact ataacgatga acaccatctt cataaatctt gggcaaatgt gattccggac      120

aaacgaggac tttacgaccc tgattatgaa catgacgctt gtggtgtcgg tttcgtagca      180

aataagcatg gtgaacagtc tcacaagatt gttactgacg ctagatatct tttagtgaat      240

atgacacatc gtggtgccgt ctcatctgat ggtaacggtg acggtgccgg tattctgcta      300

ggtattcctc acgaatttat gaaaagagaa ttcaagttag atcttgatct agacatacct      360

gagatgggca aatacgccgt aggtaacgtc ttcttcaaga agaacgaaaa aaataacaag      420

aaaaatttaa ttaagtgtca gaagattttc gaggatttag ctgcatcctt caacttatcc      480

gtattaggtt ggagaaacgt ccccgtagat tctactattt taggagacgt tgcattatct      540

cgtgaaccta ctattctaca gccattattg gttccattgt atgatgaaaa acaaccggag      600

tttaatgaaa ctaaatttag aactcaattg tatcttttaa ggaaggaggc ctctcttcaa      660

ataggactgg aaaactggtt ctatgtttgt tccctaaaca ataccaccat tgtttacaag      720

ggtcaattga cgccagctca agtgtataac tactatcccg acttgactaa tgcgcatttc      780

aaatcccaca tggcgttggt ccattcaaga ttttccacta atactttccc ctcttgggat      840

agagctcagc ctttacgttg gctagctcat aatggtgaaa ttaacacctt aagaggtaac      900

aagaattgga tgcgctccag agaaggtgtg atgaattcag caactttcaa agatgagtta      960

gacaaactat acccaattat cgaagaaggt ggttctgatt cagctgcatt ggataacgtt     1020

ttagaactat tgactattaa tggcacatta tctctacctg aagctgtaat gatgatggtt     1080

cctgaagcgt atcataagga tatggattct gacctaaaag catggtacga ctgggctgca     1140

tgtctgatgg aaccttggga tggtccagct ttgttaactt tcactgatgg acgttactgt     1200

ggtgctatat tggatagaaa tggtttaaga ccttgtcgtt attacatcac tagtgatgac     1260

agagttatct gtgcttcaga ggtaggtgtc attcctatcg aaaattcatt ggttgttcaa     1320

aaaggtaaac tgaagccagg tgatttattc ctagtggata ctcaattggg tgaaatggtc     1380

gatactaaaa agttaaaatc tcaaatctca aaaagacaag attttaagtc ttggttatcc     1440

aaagtcatca agttagacga cttgttatca aaaaccgcta atttagttcc taaagaattt     1500

atatcacagg attcattgtc tttgaaagtt caaagtgacc cacgtctatt ggccaatggt     1560

tataccttcg aacaagtcac atttctgtta actccaatgg ctttaacagg taaagaagct     1620

ttaggttcga tgggtaacga tgcgccactg gcttgtttaa atgaaaatcc tgtcttactt     1680

tatgattatt tcagacaatt gtttgctcaa gtgaccaatc ctccaattga cccaattcgt     1740

gaagcaaatg ttatgtcgtt agaatgttat gtcggacctc aaggcaacct tttggaaatg     1800

cattcatctc aatgtgatcg tttattattg aaatctccta ttttgcattg gaatgagttc     1860

caagctttga aaaacattga agctgcttac ccatcatggt ctgtagcaga aattgatatc     1920

acattcgaca agagtgaggg tctattgggc tataccgaca caattgataa aatcactaag     1980

ttagcgagcg aagcaattga tgatggtaaa aagatcttaa taattactga caggaaaatg     2040

ggtgccaacc gtgtttccat ctcctctttg attgcaattt catgtattca tcatcaccta     2100

atcagaaaca agcagcgttc ccaagttgct ttgattttgg aaacaggtga agccagagaa     2160

attcaccatt tctgtgtcct actaggttat ggttgtgatg gtgtttatcc atacttagcc     2220

atggaaactt tggtcagaat gaatagagaa ggtctacttc gtaatgtcaa caatgacaat     2280

gatacacttg aggaagggca aatactagaa aattacaagc acgctattga tgcaggtatc     2340

ttgaaggtta tgtctaaaat gggtatctcc actctagcat cctacaaagg tgctcaaatt     2400

tttgaagccc taggtttaga taactctatt gttgatttgt gtttcacagg tacttcttcc     2460

agaattagag gtgtaacttt cgagtatttg gctcaagatg ccttttcttt acatgagcgt     2520

ggttatccat ccagacaaac cattagtaaa tctgttaact taccagaaag tggtgaatac     2580

cactttaggg atggtggtta caaacacgtc aacgaaccaa ccgcaattgc ttcgttacaa     2640

gatactgtca gaaacaaaaa tgatgtctct tggcaattat atgtaaagaa ggaaatggaa     2700

gcaattagag actgtacact aagaggactg ttagaattag attttgaaaa ttctgtcagt     2760

atccctctag aacaagttga accatggact gaaattgcca gaagatttgc gtcaggtgca     2820

atgtcttatg gttctatttc tatggaagct cactctacat tggctattgc catgaatcgt     2880

ttaggggcca aatccaattg tggtgaaggt ggtgaagacg cagaacgttc tgctgttcaa     2940

gaaaacggtg atactatgag atctgctatc aaacaagttg cttccgctag attcggtgta     3000

acttcatact acttgtcaga tgctgatgaa atccaaatta agattgctca gggtgctaag     3060

ccgggtgaag gtggtgaact accagcccac aaagtgtcta aggatatcgc aaaaaccagg     3120

cactccaccc ctaatgttgg gttaatctct cctcctcctc atcacgatat ttattccatt     3180

gaagatttga aacaactgat ttatgatttg aaatgtgcta atccaagagc gggaatttct     3240

gtaaagttgg tttccgaagt tggtgttggt attgttgcct ctggtgtagc taaggctaaa     3300

gccgatcata tcttagtttc tggtcatgat ggtggtacag gtgctgcaag atggacgagt     3360

gtcaaatatg caggtttgcc atgggaatta ggtctagctg aaactcacca gactttagtc     3420

ttgaatgatt taagacgtaa tgttgttgtc caaaccgatg gtcaattgag aactgggttt     3480

gatattgctg ttgcagtttt attaggggca gaatctttta ccttggcaac agttccatta     3540

attgctatgg gttgtgttat gttaagaaga tgtcacttga actcttgtgc tgttggtatt     3600

gccacacaag atccatattt gagaagtaag tttaagggtc agcccgaaca tgttatcaac     3660

ttcttctatt acttgatcca agatttaaga caaatcatgg ccaagttagg attccgtacc     3720

attgacgaaa tggtgggcca ttctgaaaaa ttaaagaaaa gggacgacgt aaatgccaaa     3780

gccataaata tcgatttatc tcctattttg accccagcac atgttattcg tccaggtgtt     3840

ccaaccaagt tcactaagaa acaagaccac aaactccaca cccgtctaga taataagtta     3900

atcgatgagg ctgaagttac tttggatcgt ggcttaccag tgaatattga cgcctctata     3960

atcaatactg atcgtgcact cggttctact ttatcttaca gagtctcgaa gaaatttggt     4020

gaagatggtt tgccaaagga caccgttgtc gttaacatag aaggttcagc gggtcaatct     4080

tttggtgctt tcctagcttc tggtatcact tttatcttga atggtgatgc taatgattat     4140

gttggtaaag gtttatccgg tggtattatt gtcattaaac caccaaagga ttctaaattc     4200

aagagtgatg aaaatgtaat tgttggtaac acttgtttct atggtgctac ttctggtact     4260

gcattcattt caggtagtgc cggtgagcgt ttcggtgtca gaaactctgg tgccaccatc     4320

gttgttgaga gaattaaggg taacaatgcc tttgagtata tgactggtgg tcgtgccatt     4380

gtcttatcac aaatggaatc cctaaacgcc ttctctggtg ctactggtgg tattgcatac     4440

tgtttaactt ccgattacga cgattttgtt ggaaagatta acaaagatac tgttgagtta     4500

gaatcattat gtgacccggt cgagattgcg tttgttaaga atttgatcca ggagcattgg     4560

aactacacac aatctgatct agcagccagg attctcggta atttcaacca ttatttgaaa     4620

gatttcgtta aagtcattcc aactgattat aagaaagttt tgttgaagga gaaagcagaa     4680

gctaccaagg caaaggctaa ggcaacttca gaatacttaa agaagtttag atcgaaccaa     4740

gaagttgatg acgaagtcaa tactctatta attgctaatc aaaaagctaa agagcaagaa     4800

aagaagaaga gtattactat ttcaaataag gccactttga aggagcctaa ggttgttgat     4860

ttagaagatg cagttccaga ttccaaacag ctagagaaga atagcgaaag gattgaaaaa     4920

acacgtggtt ttatgatcca caaacgtcgt catgagacac acagagatcc aagaaccaga     4980

gttaatgact ggaaagaatt tactaatcct attaccaaga aggatgccaa atatcaaact     5040

gcgagatgta tggattgtgg tacaccattc tgtttgtctg ataccggttg tcccctatct     5100

aacattatcc ccaagtttaa tgaattgtta ttcaagaacc aatggaagtt ggcactggac     5160

aaattgctag agacaaacaa tttcccagaa ttcactggaa gagtatgtcc agcaccctgt     5220

gagggagctt gtacactagg tattattgaa gacccagtgg gcataaaatc ggttgaaaga     5280

attatcattg acaatgcttt caaggaagga tggattaagc cttgtccacc aagcacacgc     5340

actggcttta cagtgggtgt cattggttct ggtccagcag gtttagcgtg tgctgatatg     5400

ttgaaccgtg ccggacacac ggtcactgtt tatgaaagat ccgaccgttg tggtgggtta     5460

ttgatgtacg gtattccaaa catgaagttg gataaggcta tagtgcaacg tcgtattgat     5520

ctattgagtg ccgaaggtat tgactttgtt accaacaccg aaattggtaa aaccataagc     5580

atggatgagc taaagaacaa gcacaatgca gtagtgtatg ctatcggttc taccattcca     5640

cgtgacttac ctattaaggg tcgtgaattg aagaatattg attttgccat gcagttgttg     5700

gaatctaaca caaaagcttt attgaacaaa gatctggaaa tcattcgtga aaagatccaa     5760

ggtaagaaag taattgttgt cggtggtggt gacacaggta acgattgttt aggtacatct     5820

gtaagacacg gtgcagcatc agttttgaat ttcgaattgt tgtctgagcc accagtggaa     5880

cgtgccaaag acaatccatg gcctcaatgg ccgcgtgtca tgagagtgga ctacggtcat     5940

gctgaagtga aggagcatta tggtagagac cctcgtgaat actgcatctt gtccaaggaa     6000

tttatcggta acgatgaggg tgaagtcact gctatcagaa ctgtgcgcgt agaatggaag     6060

aagtcacaaa gtggcgtatg gcaaatggta gaaattccca acagtgaaga gatctttgaa     6120

gccgatatca ttttgttgtc catgggtttc gtgggtcctg aattgatcaa tggcaacgat     6180

aacgaagtta agaagacaag acgtggtacg attgccacac tcgacgactc ctcatactct     6240

attgatggag gaaagacttt tgcatgtggt gactgtagaa gagggcaatc tttgattgtc     6300

tgggccatcc aagaaggtag aaaatgtgct gcctctgtcg ataagttcct aatggacggc     6360

actacgtatc taccaagtaa tggtggtatc gttcaacgtg attacaaact attgaaagaa     6420

ttagctagtc aagtctaa                                                   6438


<210>  43
<211>  2145
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  43

Met Pro Val Leu Lys Ser Asp Asn Phe Asp Pro Leu Glu Glu Ala Tyr 
1               5                   10                  15      


Glu Gly Gly Thr Ile Gln Asn Tyr Asn Asp Glu His His Leu His Lys 
            20                  25                  30          


Ser Trp Ala Asn Val Ile Pro Asp Lys Arg Gly Leu Tyr Asp Pro Asp 
        35                  40                  45              


Tyr Glu His Asp Ala Cys Gly Val Gly Phe Val Ala Asn Lys His Gly 
    50                  55                  60                  


Glu Gln Ser His Lys Ile Val Thr Asp Ala Arg Tyr Leu Leu Val Asn 
65                  70                  75                  80  


Met Thr His Arg Gly Ala Val Ser Ser Asp Gly Asn Gly Asp Gly Ala 
                85                  90                  95      


Gly Ile Leu Leu Gly Ile Pro His Glu Phe Met Lys Arg Glu Phe Lys 
            100                 105                 110         


Leu Asp Leu Asp Leu Asp Ile Pro Glu Met Gly Lys Tyr Ala Val Gly 
        115                 120                 125             


Asn Val Phe Phe Lys Lys Asn Glu Lys Asn Asn Lys Lys Asn Leu Ile 
    130                 135                 140                 


Lys Cys Gln Lys Ile Phe Glu Asp Leu Ala Ala Ser Phe Asn Leu Ser 
145                 150                 155                 160 


Val Leu Gly Trp Arg Asn Val Pro Val Asp Ser Thr Ile Leu Gly Asp 
                165                 170                 175     


Val Ala Leu Ser Arg Glu Pro Thr Ile Leu Gln Pro Leu Leu Val Pro 
            180                 185                 190         


Leu Tyr Asp Glu Lys Gln Pro Glu Phe Asn Glu Thr Lys Phe Arg Thr 
        195                 200                 205             


Gln Leu Tyr Leu Leu Arg Lys Glu Ala Ser Leu Gln Ile Gly Leu Glu 
    210                 215                 220                 


Asn Trp Phe Tyr Val Cys Ser Leu Asn Asn Thr Thr Ile Val Tyr Lys 
225                 230                 235                 240 


Gly Gln Leu Thr Pro Ala Gln Val Tyr Asn Tyr Tyr Pro Asp Leu Thr 
                245                 250                 255     


Asn Ala His Phe Lys Ser His Met Ala Leu Val His Ser Arg Phe Ser 
            260                 265                 270         


Thr Asn Thr Phe Pro Ser Trp Asp Arg Ala Gln Pro Leu Arg Trp Leu 
        275                 280                 285             


Ala His Asn Gly Glu Ile Asn Thr Leu Arg Gly Asn Lys Asn Trp Met 
    290                 295                 300                 


Arg Ser Arg Glu Gly Val Met Asn Ser Ala Thr Phe Lys Asp Glu Leu 
305                 310                 315                 320 


Asp Lys Leu Tyr Pro Ile Ile Glu Glu Gly Gly Ser Asp Ser Ala Ala 
                325                 330                 335     


Leu Asp Asn Val Leu Glu Leu Leu Thr Ile Asn Gly Thr Leu Ser Leu 
            340                 345                 350         


Pro Glu Ala Val Met Met Met Val Pro Glu Ala Tyr His Lys Asp Met 
        355                 360                 365             


Asp Ser Asp Leu Lys Ala Trp Tyr Asp Trp Ala Ala Cys Leu Met Glu 
    370                 375                 380                 


Pro Trp Asp Gly Pro Ala Leu Leu Thr Phe Thr Asp Gly Arg Tyr Cys 
385                 390                 395                 400 


Gly Ala Ile Leu Asp Arg Asn Gly Leu Arg Pro Cys Arg Tyr Tyr Ile 
                405                 410                 415     


Thr Ser Asp Asp Arg Val Ile Cys Ala Ser Glu Val Gly Val Ile Pro 
            420                 425                 430         


Ile Glu Asn Ser Leu Val Val Gln Lys Gly Lys Leu Lys Pro Gly Asp 
        435                 440                 445             


Leu Phe Leu Val Asp Thr Gln Leu Gly Glu Met Val Asp Thr Lys Lys 
    450                 455                 460                 


Leu Lys Ser Gln Ile Ser Lys Arg Gln Asp Phe Lys Ser Trp Leu Ser 
465                 470                 475                 480 


Lys Val Ile Lys Leu Asp Asp Leu Leu Ser Lys Thr Ala Asn Leu Val 
                485                 490                 495     


Pro Lys Glu Phe Ile Ser Gln Asp Ser Leu Ser Leu Lys Val Gln Ser 
            500                 505                 510         


Asp Pro Arg Leu Leu Ala Asn Gly Tyr Thr Phe Glu Gln Val Thr Phe 
        515                 520                 525             


Leu Leu Thr Pro Met Ala Leu Thr Gly Lys Glu Ala Leu Gly Ser Met 
    530                 535                 540                 


Gly Asn Asp Ala Pro Leu Ala Cys Leu Asn Glu Asn Pro Val Leu Leu 
545                 550                 555                 560 


Tyr Asp Tyr Phe Arg Gln Leu Phe Ala Gln Val Thr Asn Pro Pro Ile 
                565                 570                 575     


Asp Pro Ile Arg Glu Ala Asn Val Met Ser Leu Glu Cys Tyr Val Gly 
            580                 585                 590         


Pro Gln Gly Asn Leu Leu Glu Met His Ser Ser Gln Cys Asp Arg Leu 
        595                 600                 605             


Leu Leu Lys Ser Pro Ile Leu His Trp Asn Glu Phe Gln Ala Leu Lys 
    610                 615                 620                 


Asn Ile Glu Ala Ala Tyr Pro Ser Trp Ser Val Ala Glu Ile Asp Ile 
625                 630                 635                 640 


Thr Phe Asp Lys Ser Glu Gly Leu Leu Gly Tyr Thr Asp Thr Ile Asp 
                645                 650                 655     


Lys Ile Thr Lys Leu Ala Ser Glu Ala Ile Asp Asp Gly Lys Lys Ile 
            660                 665                 670         


Leu Ile Ile Thr Asp Arg Lys Met Gly Ala Asn Arg Val Ser Ile Ser 
        675                 680                 685             


Ser Leu Ile Ala Ile Ser Cys Ile His His His Leu Ile Arg Asn Lys 
    690                 695                 700                 


Gln Arg Ser Gln Val Ala Leu Ile Leu Glu Thr Gly Glu Ala Arg Glu 
705                 710                 715                 720 


Ile His His Phe Cys Val Leu Leu Gly Tyr Gly Cys Asp Gly Val Tyr 
                725                 730                 735     


Pro Tyr Leu Ala Met Glu Thr Leu Val Arg Met Asn Arg Glu Gly Leu 
            740                 745                 750         


Leu Arg Asn Val Asn Asn Asp Asn Asp Thr Leu Glu Glu Gly Gln Ile 
        755                 760                 765             


Leu Glu Asn Tyr Lys His Ala Ile Asp Ala Gly Ile Leu Lys Val Met 
    770                 775                 780                 


Ser Lys Met Gly Ile Ser Thr Leu Ala Ser Tyr Lys Gly Ala Gln Ile 
785                 790                 795                 800 


Phe Glu Ala Leu Gly Leu Asp Asn Ser Ile Val Asp Leu Cys Phe Thr 
                805                 810                 815     


Gly Thr Ser Ser Arg Ile Arg Gly Val Thr Phe Glu Tyr Leu Ala Gln 
            820                 825                 830         


Asp Ala Phe Ser Leu His Glu Arg Gly Tyr Pro Ser Arg Gln Thr Ile 
        835                 840                 845             


Ser Lys Ser Val Asn Leu Pro Glu Ser Gly Glu Tyr His Phe Arg Asp 
    850                 855                 860                 


Gly Gly Tyr Lys His Val Asn Glu Pro Thr Ala Ile Ala Ser Leu Gln 
865                 870                 875                 880 


Asp Thr Val Arg Asn Lys Asn Asp Val Ser Trp Gln Leu Tyr Val Lys 
                885                 890                 895     


Lys Glu Met Glu Ala Ile Arg Asp Cys Thr Leu Arg Gly Leu Leu Glu 
            900                 905                 910         


Leu Asp Phe Glu Asn Ser Val Ser Ile Pro Leu Glu Gln Val Glu Pro 
        915                 920                 925             


Trp Thr Glu Ile Ala Arg Arg Phe Ala Ser Gly Ala Met Ser Tyr Gly 
    930                 935                 940                 


Ser Ile Ser Met Glu Ala His Ser Thr Leu Ala Ile Ala Met Asn Arg 
945                 950                 955                 960 


Leu Gly Ala Lys Ser Asn Cys Gly Glu Gly Gly Glu Asp Ala Glu Arg 
                965                 970                 975     


Ser Ala Val Gln Glu Asn Gly Asp Thr Met Arg Ser Ala Ile Lys Gln 
            980                 985                 990         


Val Ala Ser Ala Arg Phe Gly Val  Thr Ser Tyr Tyr Leu  Ser Asp Ala 
        995                 1000                 1005             


Asp Glu  Ile Gln Ile Lys Ile  Ala Gln Gly Ala Lys  Pro Gly Glu 
    1010                 1015                 1020             


Gly Gly  Glu Leu Pro Ala His  Lys Val Ser Lys Asp  Ile Ala Lys 
    1025                 1030                 1035             


Thr Arg  His Ser Thr Pro Asn  Val Gly Leu Ile Ser  Pro Pro Pro 
    1040                 1045                 1050             


His His  Asp Ile Tyr Ser Ile  Glu Asp Leu Lys Gln  Leu Ile Tyr 
    1055                 1060                 1065             


Asp Leu  Lys Cys Ala Asn Pro  Arg Ala Gly Ile Ser  Val Lys Leu 
    1070                 1075                 1080             


Val Ser  Glu Val Gly Val Gly  Ile Val Ala Ser Gly  Val Ala Lys 
    1085                 1090                 1095             


Ala Lys  Ala Asp His Ile Leu  Val Ser Gly His Asp  Gly Gly Thr 
    1100                 1105                 1110             


Gly Ala  Ala Arg Trp Thr Ser  Val Lys Tyr Ala Gly  Leu Pro Trp 
    1115                 1120                 1125             


Glu Leu  Gly Leu Ala Glu Thr  His Gln Thr Leu Val  Leu Asn Asp 
    1130                 1135                 1140             


Leu Arg  Arg Asn Val Val Val  Gln Thr Asp Gly Gln  Leu Arg Thr 
    1145                 1150                 1155             


Gly Phe  Asp Ile Ala Val Ala  Val Leu Leu Gly Ala  Glu Ser Phe 
    1160                 1165                 1170             


Thr Leu  Ala Thr Val Pro Leu  Ile Ala Met Gly Cys  Val Met Leu 
    1175                 1180                 1185             


Arg Arg  Cys His Leu Asn Ser  Cys Ala Val Gly Ile  Ala Thr Gln 
    1190                 1195                 1200             


Asp Pro  Tyr Leu Arg Ser Lys  Phe Lys Gly Gln Pro  Glu His Val 
    1205                 1210                 1215             


Ile Asn  Phe Phe Tyr Tyr Leu  Ile Gln Asp Leu Arg  Gln Ile Met 
    1220                 1225                 1230             


Ala Lys  Leu Gly Phe Arg Thr  Ile Asp Glu Met Val  Gly His Ser 
    1235                 1240                 1245             


Glu Lys  Leu Lys Lys Arg Asp  Asp Val Asn Ala Lys  Ala Ile Asn 
    1250                 1255                 1260             


Ile Asp  Leu Ser Pro Ile Leu  Thr Pro Ala His Val  Ile Arg Pro 
    1265                 1270                 1275             


Gly Val  Pro Thr Lys Phe Thr  Lys Lys Gln Asp His  Lys Leu His 
    1280                 1285                 1290             


Thr Arg  Leu Asp Asn Lys Leu  Ile Asp Glu Ala Glu  Val Thr Leu 
    1295                 1300                 1305             


Asp Arg  Gly Leu Pro Val Asn  Ile Asp Ala Ser Ile  Ile Asn Thr 
    1310                 1315                 1320             


Asp Arg  Ala Leu Gly Ser Thr  Leu Ser Tyr Arg Val  Ser Lys Lys 
    1325                 1330                 1335             


Phe Gly  Glu Asp Gly Leu Pro  Lys Asp Thr Val Val  Val Asn Ile 
    1340                 1345                 1350             


Glu Gly  Ser Ala Gly Gln Ser  Phe Gly Ala Phe Leu  Ala Ser Gly 
    1355                 1360                 1365             


Ile Thr  Phe Ile Leu Asn Gly  Asp Ala Asn Asp Tyr  Val Gly Lys 
    1370                 1375                 1380             


Gly Leu  Ser Gly Gly Ile Ile  Val Ile Lys Pro Pro  Lys Asp Ser 
    1385                 1390                 1395             


Lys Phe  Lys Ser Asp Glu Asn  Val Ile Val Gly Asn  Thr Cys Phe 
    1400                 1405                 1410             


Tyr Gly  Ala Thr Ser Gly Thr  Ala Phe Ile Ser Gly  Ser Ala Gly 
    1415                 1420                 1425             


Glu Arg  Phe Gly Val Arg Asn  Ser Gly Ala Thr Ile  Val Val Glu 
    1430                 1435                 1440             


Arg Ile  Lys Gly Asn Asn Ala  Phe Glu Tyr Met Thr  Gly Gly Arg 
    1445                 1450                 1455             


Ala Ile  Val Leu Ser Gln Met  Glu Ser Leu Asn Ala  Phe Ser Gly 
    1460                 1465                 1470             


Ala Thr  Gly Gly Ile Ala Tyr  Cys Leu Thr Ser Asp  Tyr Asp Asp 
    1475                 1480                 1485             


Phe Val  Gly Lys Ile Asn Lys  Asp Thr Val Glu Leu  Glu Ser Leu 
    1490                 1495                 1500             


Cys Asp  Pro Val Glu Ile Ala  Phe Val Lys Asn Leu  Ile Gln Glu 
    1505                 1510                 1515             


His Trp  Asn Tyr Thr Gln Ser  Asp Leu Ala Ala Arg  Ile Leu Gly 
    1520                 1525                 1530             


Asn Phe  Asn His Tyr Leu Lys  Asp Phe Val Lys Val  Ile Pro Thr 
    1535                 1540                 1545             


Asp Tyr  Lys Lys Val Leu Leu  Lys Glu Lys Ala Glu  Ala Thr Lys 
    1550                 1555                 1560             


Ala Lys  Ala Lys Ala Thr Ser  Glu Tyr Leu Lys Lys  Phe Arg Ser 
    1565                 1570                 1575             


Asn Gln  Glu Val Asp Asp Glu  Val Asn Thr Leu Leu  Ile Ala Asn 
    1580                 1585                 1590             


Gln Lys  Ala Lys Glu Gln Glu  Lys Lys Lys Ser Ile  Thr Ile Ser 
    1595                 1600                 1605             


Asn Lys  Ala Thr Leu Lys Glu  Pro Lys Val Val Asp  Leu Glu Asp 
    1610                 1615                 1620             


Ala Val  Pro Asp Ser Lys Gln  Leu Glu Lys Asn Ser  Glu Arg Ile 
    1625                 1630                 1635             


Glu Lys  Thr Arg Gly Phe Met  Ile His Lys Arg Arg  His Glu Thr 
    1640                 1645                 1650             


His Arg  Asp Pro Arg Thr Arg  Val Asn Asp Trp Lys  Glu Phe Thr 
    1655                 1660                 1665             


Asn Pro  Ile Thr Lys Lys Asp  Ala Lys Tyr Gln Thr  Ala Arg Cys 
    1670                 1675                 1680             


Met Asp  Cys Gly Thr Pro Phe  Cys Leu Ser Asp Thr  Gly Cys Pro 
    1685                 1690                 1695             


Leu Ser  Asn Ile Ile Pro Lys  Phe Asn Glu Leu Leu  Phe Lys Asn 
    1700                 1705                 1710             


Gln Trp  Lys Leu Ala Leu Asp  Lys Leu Leu Glu Thr  Asn Asn Phe 
    1715                 1720                 1725             


Pro Glu  Phe Thr Gly Arg Val  Cys Pro Ala Pro Cys  Glu Gly Ala 
    1730                 1735                 1740             


Cys Thr  Leu Gly Ile Ile Glu  Asp Pro Val Gly Ile  Lys Ser Val 
    1745                 1750                 1755             


Glu Arg  Ile Ile Ile Asp Asn  Ala Phe Lys Glu Gly  Trp Ile Lys 
    1760                 1765                 1770             


Pro Cys  Pro Pro Ser Thr Arg  Thr Gly Phe Thr Val  Gly Val Ile 
    1775                 1780                 1785             


Gly Ser  Gly Pro Ala Gly Leu  Ala Cys Ala Asp Met  Leu Asn Arg 
    1790                 1795                 1800             


Ala Gly  His Thr Val Thr Val  Tyr Glu Arg Ser Asp  Arg Cys Gly 
    1805                 1810                 1815             


Gly Leu  Leu Met Tyr Gly Ile  Pro Asn Met Lys Leu  Asp Lys Ala 
    1820                 1825                 1830             


Ile Val  Gln Arg Arg Ile Asp  Leu Leu Ser Ala Glu  Gly Ile Asp 
    1835                 1840                 1845             


Phe Val  Thr Asn Thr Glu Ile  Gly Lys Thr Ile Ser  Met Asp Glu 
    1850                 1855                 1860             


Leu Lys  Asn Lys His Asn Ala  Val Val Tyr Ala Ile  Gly Ser Thr 
    1865                 1870                 1875             


Ile Pro  Arg Asp Leu Pro Ile  Lys Gly Arg Glu Leu  Lys Asn Ile 
    1880                 1885                 1890             


Asp Phe  Ala Met Gln Leu Leu  Glu Ser Asn Thr Lys  Ala Leu Leu 
    1895                 1900                 1905             


Asn Lys  Asp Leu Glu Ile Ile  Arg Glu Lys Ile Gln  Gly Lys Lys 
    1910                 1915                 1920             


Val Ile  Val Val Gly Gly Gly  Asp Thr Gly Asn Asp  Cys Leu Gly 
    1925                 1930                 1935             


Thr Ser  Val Arg His Gly Ala  Ala Ser Val Leu Asn  Phe Glu Leu 
    1940                 1945                 1950             


Leu Ser  Glu Pro Pro Val Glu  Arg Ala Lys Asp Asn  Pro Trp Pro 
    1955                 1960                 1965             


Gln Trp  Pro Arg Val Met Arg  Val Asp Tyr Gly His  Ala Glu Val 
    1970                 1975                 1980             


Lys Glu  His Tyr Gly Arg Asp  Pro Arg Glu Tyr Cys  Ile Leu Ser 
    1985                 1990                 1995             


Lys Glu  Phe Ile Gly Asn Asp  Glu Gly Glu Val Thr  Ala Ile Arg 
    2000                 2005                 2010             


Thr Val  Arg Val Glu Trp Lys  Lys Ser Gln Ser Gly  Val Trp Gln 
    2015                 2020                 2025             


Met Val  Glu Ile Pro Asn Ser  Glu Glu Ile Phe Glu  Ala Asp Ile 
    2030                 2035                 2040             


Ile Leu  Leu Ser Met Gly Phe  Val Gly Pro Glu Leu  Ile Asn Gly 
    2045                 2050                 2055             


Asn Asp  Asn Glu Val Lys Lys  Thr Arg Arg Gly Thr  Ile Ala Thr 
    2060                 2065                 2070             


Leu Asp  Asp Ser Ser Tyr Ser  Ile Asp Gly Gly Lys  Thr Phe Ala 
    2075                 2080                 2085             


Cys Gly  Asp Cys Arg Arg Gly  Gln Ser Leu Ile Val  Trp Ala Ile 
    2090                 2095                 2100             


Gln Glu  Gly Arg Lys Cys Ala  Ala Ser Val Asp Lys  Phe Leu Met 
    2105                 2110                 2115             


Asp Gly  Thr Thr Tyr Leu Pro  Ser Asn Gly Gly Ile  Val Gln Arg 
    2120                 2125                 2130             


Asp Tyr  Lys Leu Leu Lys Glu  Leu Ala Ser Gln Val  
    2135                 2140                 2145 


<210>  44
<211>  1113
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  44
atggctgaag caagcatcga aaagactcaa attttacaaa aatatctaga actggaccaa       60

agaggtagaa taattgccga atacgtttgg atcgatggta ctggtaactt acgttccaaa      120

ggtagaactt tgaagaagag aatcacatcc attgaccaat tgccagaatg gaacttcgac      180

ggttcttcta ccaaccaagc gccaggccac gactctgaca tctatttgaa acccgttgct      240

tactacccag atcctttcag gagaggtgac aacattgttg tcttggccgc atgttacaac      300

aatgacggta ctccaaacaa gttcaaccac agacacgaag ctgccaagct atttgctgct      360

cataaggatg aagaaatctg gtttggtcta gaacaagaat acactctatt tgacatgtat      420

gacgatgttt acggatggcc aaagggtggg tacccagctc cacaaggtcc ttactactgt      480

ggtgttggtg ccggtaaggt ttatgccaga gacatgatcg aagctcacta cagagcttgt      540

ttgtatgccg gattagaaat ttctggtatt aacgctgaag ttatgccatc tcaatgggaa      600

ttccaagtcg gtccatgtac cggtattgac atgggtgacc aattatggat ggccagatac      660

tttttgcaca gagtggcaga agagtttggt atcaagatct cattccatcc aaagccattg      720

aagggtgact ggaacggtgc cggttgtcac actaacgttt ccaccaagga aatgagacaa      780

ccaggtggta tgaaatacat cgaacaagcc atcgagaagt tatccaagag acacgctgaa      840

cacattaagt tgtacggtag cgataacgac atgagattaa ctggtagaca tgaaaccgct      900

tccatgactg ccttttcttc tggtgtcgcc aacagaggta gctcaattag aatcccaaga      960

tccgtcgcca aggaaggtta cggttacttt gaagaccgta gaccagcttc caacatcgac     1020

ccatacttgg ttacaggtat catgtgtgaa actgtttgcg gtgctattga caatgctgac     1080

atgacgaagg aatttgaaag agaatcttca taa                                  1113


<210>  45
<211>  370
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  45

Met Ala Glu Ala Ser Ile Glu Lys Thr Gln Ile Leu Gln Lys Tyr Leu 
1               5                   10                  15      


Glu Leu Asp Gln Arg Gly Arg Ile Ile Ala Glu Tyr Val Trp Ile Asp 
            20                  25                  30          


Gly Thr Gly Asn Leu Arg Ser Lys Gly Arg Thr Leu Lys Lys Arg Ile 
        35                  40                  45              


Thr Ser Ile Asp Gln Leu Pro Glu Trp Asn Phe Asp Gly Ser Ser Thr 
    50                  55                  60                  


Asn Gln Ala Pro Gly His Asp Ser Asp Ile Tyr Leu Lys Pro Val Ala 
65                  70                  75                  80  


Tyr Tyr Pro Asp Pro Phe Arg Arg Gly Asp Asn Ile Val Val Leu Ala 
                85                  90                  95      


Ala Cys Tyr Asn Asn Asp Gly Thr Pro Asn Lys Phe Asn His Arg His 
            100                 105                 110         


Glu Ala Ala Lys Leu Phe Ala Ala His Lys Asp Glu Glu Ile Trp Phe 
        115                 120                 125             


Gly Leu Glu Gln Glu Tyr Thr Leu Phe Asp Met Tyr Asp Asp Val Tyr 
    130                 135                 140                 


Gly Trp Pro Lys Gly Gly Tyr Pro Ala Pro Gln Gly Pro Tyr Tyr Cys 
145                 150                 155                 160 


Gly Val Gly Ala Gly Lys Val Tyr Ala Arg Asp Met Ile Glu Ala His 
                165                 170                 175     


Tyr Arg Ala Cys Leu Tyr Ala Gly Leu Glu Ile Ser Gly Ile Asn Ala 
            180                 185                 190         


Glu Val Met Pro Ser Gln Trp Glu Phe Gln Val Gly Pro Cys Thr Gly 
        195                 200                 205             


Ile Asp Met Gly Asp Gln Leu Trp Met Ala Arg Tyr Phe Leu His Arg 
    210                 215                 220                 


Val Ala Glu Glu Phe Gly Ile Lys Ile Ser Phe His Pro Lys Pro Leu 
225                 230                 235                 240 


Lys Gly Asp Trp Asn Gly Ala Gly Cys His Thr Asn Val Ser Thr Lys 
                245                 250                 255     


Glu Met Arg Gln Pro Gly Gly Met Lys Tyr Ile Glu Gln Ala Ile Glu 
            260                 265                 270         


Lys Leu Ser Lys Arg His Ala Glu His Ile Lys Leu Tyr Gly Ser Asp 
        275                 280                 285             


Asn Asp Met Arg Leu Thr Gly Arg His Glu Thr Ala Ser Met Thr Ala 
    290                 295                 300                 


Phe Ser Ser Gly Val Ala Asn Arg Gly Ser Ser Ile Arg Ile Pro Arg 
305                 310                 315                 320 


Ser Val Ala Lys Glu Gly Tyr Gly Tyr Phe Glu Asp Arg Arg Pro Ala 
                325                 330                 335     


Ser Asn Ile Asp Pro Tyr Leu Val Thr Gly Ile Met Cys Glu Thr Val 
            340                 345                 350         


Cys Gly Ala Ile Asp Asn Ala Asp Met Thr Lys Glu Phe Glu Arg Glu 
        355                 360                 365             


Ser Ser 
    370 


<210>  46
<211>  1431
<212>  DNA
<213>  Lactobacillus delbrueckii

<400>  46
atgaccgaac actacttgaa ctacgttaat ggtgaatggc gtgattctgc tgatgccatt       60

gaaatttttg aaccagctac tggtaagtcc ttgggtactg ttccagctat gtctcatgaa      120

gatgttgatt acgttatgaa ctccgctaaa aaagctttgc cagcttggag agctttgtct      180

tatgttgaaa gagctgctta cttgcaaaag gctgctgata tcttgtatag agatgccgaa      240

aagattggct ccaccttgtc taaagaaatt gccaagggtt tgaagtcctc cattggtgaa      300

gttactagaa ctgctgaaat cgttgagtac actgctaaag ttggtgttac tttggatggt      360

gaagtaatgg aaggtggtaa ttttgaagct gcctctaaaa acaagttggc cgttgttaga      420

agagaaccag ttggtttggt tttggctatt tctccattca actacccagt taatttggcc      480

ggttctaaaa ttgctccagc tttgatgggt ggtaatgttg ttgcttttaa accaccaact      540

cagggttcta tttctggttt gttgttagct aaggcttttg ctgaagctgg tttgcctgct      600

ggtgttttta acactattac tggtagaggt agagtcatcg gtgattacat cgttgaacat      660

ccagctgtta acttcatcaa ctttactggt tcttctgccg ttggtaagaa tattggtaaa      720

ttggctggta tgaggccaat catgttggaa ttaggtggta aagatgctgc catcgttttg      780

gaagatgctg atttggattt gaccgctaag aatatcgttg ctggtgcttt tggttattct      840

ggtcaaagat gtactgctgt taagcgtgtt ttggtcatgg attctgttgc tgatgaattg      900

gttgaaaagg ttactgcttt ggccaaggat ttgactgttg gtattcctga agaagatgcc      960

gatattactc cattgattga taccaagtct gccgattatg ttcagggttt gattgaagag     1020

gctgcagaaa aaggtgctaa acctttgttt gacttcaaga gagaaggcaa cttgatctac     1080

ccaatggtta tggatcaagt taccaccgat atgagattgg cttgggaaga accatttggt     1140

ccagttttgc ctttcatcag agttaagtca gctgatgaag ctgttatgat tgccaacgaa     1200

tctgaatatg gcttgcagtc ctctgttttc tctagaaatt ttgaaaaggc tttcgccatt     1260

gccggtaagt tggaagttgg tacagttcat attaacaaca agacccaaag aggtccagat     1320

aactttccat ttttgggtgt taagtcatct ggtgccggtg ttcaaggtgt caaatattct     1380

attcaagcta tgaccagagt caagtccgtt gttttcaaca tcgaagatta a              1431


<210>  47
<211>  476
<212>  PRT
<213>  Lactobacillus delbrueckii

<400>  47

Met Thr Glu His Tyr Leu Asn Tyr Val Asn Gly Glu Trp Arg Asp Ser 
1               5                   10                  15      


Ala Asp Ala Ile Glu Ile Phe Glu Pro Ala Thr Gly Lys Ser Leu Gly 
            20                  25                  30          


Thr Val Pro Ala Met Ser His Glu Asp Val Asp Tyr Val Met Asn Ser 
        35                  40                  45              


Ala Lys Lys Ala Leu Pro Ala Trp Arg Ala Leu Ser Tyr Val Glu Arg 
    50                  55                  60                  


Ala Ala Tyr Leu Gln Lys Ala Ala Asp Ile Leu Tyr Arg Asp Ala Glu 
65                  70                  75                  80  


Lys Ile Gly Ser Thr Leu Ser Lys Glu Ile Ala Lys Gly Leu Lys Ser 
                85                  90                  95      


Ser Ile Gly Glu Val Thr Arg Thr Ala Glu Ile Val Glu Tyr Thr Ala 
            100                 105                 110         


Lys Val Gly Val Thr Leu Asp Gly Glu Val Met Glu Gly Gly Asn Phe 
        115                 120                 125             


Glu Ala Ala Ser Lys Asn Lys Leu Ala Val Val Arg Arg Glu Pro Val 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Val Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Met Gly Gly Asn Val Val Ala Phe 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Leu Leu Ala Lys Ala 
            180                 185                 190         


Phe Ala Glu Ala Gly Leu Pro Ala Gly Val Phe Asn Thr Ile Thr Gly 
        195                 200                 205             


Arg Gly Arg Val Ile Gly Asp Tyr Ile Val Glu His Pro Ala Val Asn 
    210                 215                 220                 


Phe Ile Asn Phe Thr Gly Ser Ser Ala Val Gly Lys Asn Ile Gly Lys 
225                 230                 235                 240 


Leu Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ala 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Asp Leu Thr Ala Lys Asn Ile 
            260                 265                 270         


Val Ala Gly Ala Phe Gly Tyr Ser Gly Gln Arg Cys Thr Ala Val Lys 
        275                 280                 285             


Arg Val Leu Val Met Asp Ser Val Ala Asp Glu Leu Val Glu Lys Val 
    290                 295                 300                 


Thr Ala Leu Ala Lys Asp Leu Thr Val Gly Ile Pro Glu Glu Asp Ala 
305                 310                 315                 320 


Asp Ile Thr Pro Leu Ile Asp Thr Lys Ser Ala Asp Tyr Val Gln Gly 
                325                 330                 335     


Leu Ile Glu Glu Ala Ala Glu Lys Gly Ala Lys Pro Leu Phe Asp Phe 
            340                 345                 350         


Lys Arg Glu Gly Asn Leu Ile Tyr Pro Met Val Met Asp Gln Val Thr 
        355                 360                 365             


Thr Asp Met Arg Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Phe Ile Arg Val Lys Ser Ala Asp Glu Ala Val Met Ile Ala Asn Glu 
385                 390                 395                 400 


Ser Glu Tyr Gly Leu Gln Ser Ser Val Phe Ser Arg Asn Phe Glu Lys 
                405                 410                 415     


Ala Phe Ala Ile Ala Gly Lys Leu Glu Val Gly Thr Val His Ile Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Pro Asp Asn Phe Pro Phe Leu Gly Val Lys 
        435                 440                 445             


Ser Ser Gly Ala Gly Val Gln Gly Val Lys Tyr Ser Ile Gln Ala Met 
    450                 455                 460                 


Thr Arg Val Lys Ser Val Val Phe Asn Ile Glu Asp 
465                 470                 475     


<210>  48
<211>  1434
<212>  DNA
<213>  Streptococcus thermophilus

<400>  48
atggctaagc agtacaagaa ctacgttaac ggtgaatgga aaacctccga aaactctatt       60

actatctacg ctccagctaa tggtgaagaa ttgggttctg ttccagctat gtctcaagct      120

gaagttgatg aagtttatgc tgctgctaaa gctgctttgc cagcttggag agctttgtct      180

tatgctgaaa gagctgctta cttgcataag gctgctgata ttttggaaag agatgccgaa      240

aagatcggtc aggttttgtc taaagaaatc tccaagggtt tgaagtccgc tattggtgaa      300

gttgttagaa ccgccgaaat tattcattac gctgctgaag aaggtttgag gttggaaggt      360

gaagtattag aaggtggtgc ttttgatgct ggttccaaaa aaaagattgc cgtcgttaga      420

agagaaccag ttggtttggt tttggctatt tctccattca actacccagt taatttggcc      480

ggttcaaaaa ttgctccagc tttgattgct ggtgatgttg ttgcttttaa accaccaact      540

caaggttcca tttctggttt gttgttggtt gaagcttttg tcgaagctgg tattccagct      600

ggtgttttga attctattac tggtagaggt tccgttatcg gtgattatat cgttgaacac      660

aaggccgttg atttcattaa cttcactggt tctactccag tcggtgaaaa cattggtaga      720

ttggctgcta tgaggccagt tatgttggaa ttaggtggta aagatgctgc catcgttttg      780

gaagatgctg atttggattt gaccgctaag aatatcgttg ctggtgcttt cgattattct      840

ggtcaaagat gtactgccat taagcgtgtt ttggttatgg attctgttgc cgatgaattg      900

gttgaaaagg ttactgcttt ggttggtaac attactgttg gtatgccaga agaatctgct      960

tctgttactc cattgattga taccaaagct gccgattttg ttcaaggttt gattgatgat     1020

gctgttgaac aaggtgctac tgctaaaact gaattgaaga gagaaggcaa cttgatctac     1080

ccagctgttt ttgatcatgt taccaccgat atgagattgg cttgggaaga accatttggt     1140

ccagttttgc cttttatcag agtttcctct gttgaagaag ccatcaagat ctctaacgaa     1200

tctgaattcg gtttacaagg tgccgttttc actcaagatt atccaagagc ttttgccatt     1260

gccgaacaat tggaagttgg tactgttcac attaacaaca agacccaaag aggtactgat     1320

aactttccat tcttgggtgt aaaaggttct ggtgctggta ctcaaggtgt taagtattct     1380

attgaagcta tgaccagagt caagtccacc gtttttgata tctctgacta ctaa           1434


<210>  49
<211>  477
<212>  PRT
<213>  Streptococcus thermophilus

<400>  49

Met Ala Lys Gln Tyr Lys Asn Tyr Val Asn Gly Glu Trp Lys Thr Ser 
1               5                   10                  15      


Glu Asn Ser Ile Thr Ile Tyr Ala Pro Ala Asn Gly Glu Glu Leu Gly 
            20                  25                  30          


Ser Val Pro Ala Met Ser Gln Ala Glu Val Asp Glu Val Tyr Ala Ala 
        35                  40                  45              


Ala Lys Ala Ala Leu Pro Ala Trp Arg Ala Leu Ser Tyr Ala Glu Arg 
    50                  55                  60                  


Ala Ala Tyr Leu His Lys Ala Ala Asp Ile Leu Glu Arg Asp Ala Glu 
65                  70                  75                  80  


Lys Ile Gly Gln Val Leu Ser Lys Glu Ile Ser Lys Gly Leu Lys Ser 
                85                  90                  95      


Ala Ile Gly Glu Val Val Arg Thr Ala Glu Ile Ile His Tyr Ala Ala 
            100                 105                 110         


Glu Glu Gly Leu Arg Leu Glu Gly Glu Val Leu Glu Gly Gly Ala Phe 
        115                 120                 125             


Asp Ala Gly Ser Lys Lys Lys Ile Ala Val Val Arg Arg Glu Pro Val 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Val Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Ile Ala Gly Asp Val Val Ala Phe 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Leu Leu Val Glu Ala 
            180                 185                 190         


Phe Val Glu Ala Gly Ile Pro Ala Gly Val Leu Asn Ser Ile Thr Gly 
        195                 200                 205             


Arg Gly Ser Val Ile Gly Asp Tyr Ile Val Glu His Lys Ala Val Asp 
    210                 215                 220                 


Phe Ile Asn Phe Thr Gly Ser Thr Pro Val Gly Glu Asn Ile Gly Arg 
225                 230                 235                 240 


Leu Ala Ala Met Arg Pro Val Met Leu Glu Leu Gly Gly Lys Asp Ala 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Asp Leu Thr Ala Lys Asn Ile 
            260                 265                 270         


Val Ala Gly Ala Phe Asp Tyr Ser Gly Gln Arg Cys Thr Ala Ile Lys 
        275                 280                 285             


Arg Val Leu Val Met Asp Ser Val Ala Asp Glu Leu Val Glu Lys Val 
    290                 295                 300                 


Thr Ala Leu Val Gly Asn Ile Thr Val Gly Met Pro Glu Glu Ser Ala 
305                 310                 315                 320 


Ser Val Thr Pro Leu Ile Asp Thr Lys Ala Ala Asp Phe Val Gln Gly 
                325                 330                 335     


Leu Ile Asp Asp Ala Val Glu Gln Gly Ala Thr Ala Lys Thr Glu Leu 
            340                 345                 350         


Lys Arg Glu Gly Asn Leu Ile Tyr Pro Ala Val Phe Asp His Val Thr 
        355                 360                 365             


Thr Asp Met Arg Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Phe Ile Arg Val Ser Ser Val Glu Glu Ala Ile Lys Ile Ser Asn Glu 
385                 390                 395                 400 


Ser Glu Phe Gly Leu Gln Gly Ala Val Phe Thr Gln Asp Tyr Pro Arg 
                405                 410                 415     


Ala Phe Ala Ile Ala Glu Gln Leu Glu Val Gly Thr Val His Ile Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Thr Asp Asn Phe Pro Phe Leu Gly Val Lys 
        435                 440                 445             


Gly Ser Gly Ala Gly Thr Gln Gly Val Lys Tyr Ser Ile Glu Ala Met 
    450                 455                 460                 


Thr Arg Val Lys Ser Thr Val Phe Asp Ile Ser Asp Tyr 
465                 470                 475         


<210>  50
<211>  1428
<212>  DNA
<213>  Streptococcus macacae

<400>  50
atgaccaagc agtacaagga ttacgttaat ggtgaatgga agctgtccaa gaacgatatc       60

aaaatctatg aaccagcttc cggtgctgaa ttgggtttag ttccagctat gtctactgaa      120

gaggttgatt atgtttatgc ttccgctcat aaggctttga aagaatggcg tgctttgtct      180

tatgttgaaa gagctgctta cttgcataag gttgccgata ttttggaaag agatgccgaa      240

aaaattggtg ccgtcttgtc taaagaagtt gctaaaggtt acaagtccgc cgtttctgaa      300

gttattagaa ccgctgaaat tatcaactac gctgctgaag agggtttgag aatggaaggt      360

gaagttttgg aaggtggttc ttttgaagct gcttccaaaa agaagattgc cgttgttaga      420

agagaaccag ttggtttggt tttggctatt tctccattca actacccagt taatttggcc      480

ggttctaaaa ttgctccagc tttgattgct ggtaacgttg ttgcttttaa accaccaact      540

caaggttcca tttctggttt gttgttggct gaagcttttg ctgaagcagg tttgccagct      600

ggtgttttta acactattac tggtagaggt tccgaaatcg gtgattacat cgttgaacat      660

ccagctgtta acttcatcaa cttcactggt tctactccaa tcggtgaaag aattggtaga      720

atggctggta tgaggccaat catgttggaa ttaggtggta aagattccgc cattgtcttg      780

gaagatgctg atttggaatt gaccgctaag aatatcgttg ctggtgcttt tggttattct      840

ggtcaaagat gtactgctgt taagcgtgtt ttagttatgg aaggcgttgc tgataagttg      900

gtcgaaaaga ttagagaaaa ggttttggcc ttgaccattg gtaatccaga aaacgatgct      960

gatattaccc cattgattga taccaaggct gctgattttg ttgaaggttt gattaacgac     1020

gccaaagaaa agggtgctga taacttgact gaaatcaaga gagaaggtaa cttgatctgc     1080

ccagttttgt tcgataaggt tactaccgat atgagattgg cttgggaaga accatttggt     1140

ccagttttgc caattatcag agttaagtct gtcgaagaag ccattgccat ctctaatcaa     1200

tctgaatacg gtctgcaagc ctctattttc actaatgatt ttccaagagc tttcggtatc     1260

gccgaacaat tggaagttgg tactgttcat ttgaacaaca agacccaaag aggtacagat     1320

aactttccat ttttgggcgc taaaaaatca ggtgctggta ttcaaggtgt caagtactct     1380

attgaagcta tgactaccgt caagtccgtt gttttcgata tcaagtga                  1428


<210>  51
<211>  475
<212>  PRT
<213>  Streptococcus macacae

<400>  51

Met Thr Lys Gln Tyr Lys Asp Tyr Val Asn Gly Glu Trp Lys Leu Ser 
1               5                   10                  15      


Lys Asn Asp Ile Lys Ile Tyr Glu Pro Ala Ser Gly Ala Glu Leu Gly 
            20                  25                  30          


Leu Val Pro Ala Met Ser Thr Glu Glu Val Asp Tyr Val Tyr Ala Ser 
        35                  40                  45              


Ala His Lys Ala Leu Lys Glu Trp Arg Ala Leu Ser Tyr Val Glu Arg 
    50                  55                  60                  


Ala Ala Tyr Leu His Lys Val Ala Asp Ile Leu Glu Arg Asp Ala Glu 
65                  70                  75                  80  


Lys Ile Gly Ala Val Leu Ser Lys Glu Val Ala Lys Gly Tyr Lys Ser 
                85                  90                  95      


Ala Val Ser Glu Val Ile Arg Thr Ala Glu Ile Ile Asn Tyr Ala Ala 
            100                 105                 110         


Glu Glu Gly Leu Arg Met Glu Gly Glu Val Leu Glu Gly Gly Ser Phe 
        115                 120                 125             


Glu Ala Ala Ser Lys Lys Lys Ile Ala Val Val Arg Arg Glu Pro Val 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Val Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Ile Ala Gly Asn Val Val Ala Phe 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Leu Leu Ala Glu Ala 
            180                 185                 190         


Phe Ala Glu Ala Gly Leu Pro Ala Gly Val Phe Asn Thr Ile Thr Gly 
        195                 200                 205             


Arg Gly Ser Glu Ile Gly Asp Tyr Ile Val Glu His Pro Ala Val Asn 
    210                 215                 220                 


Phe Ile Asn Phe Thr Gly Ser Thr Pro Ile Gly Glu Arg Ile Gly Arg 
225                 230                 235                 240 


Met Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ser 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Glu Leu Thr Ala Lys Asn Ile 
            260                 265                 270         


Val Ala Gly Ala Phe Gly Tyr Ser Gly Gln Arg Cys Thr Ala Val Lys 
        275                 280                 285             


Arg Val Leu Val Met Glu Gly Val Ala Asp Lys Leu Val Glu Lys Ile 
    290                 295                 300                 


Arg Glu Lys Val Leu Ala Leu Thr Ile Gly Asn Pro Glu Asn Asp Ala 
305                 310                 315                 320 


Asp Ile Thr Pro Leu Ile Asp Thr Lys Ala Ala Asp Phe Val Glu Gly 
                325                 330                 335     


Leu Ile Asn Asp Ala Lys Glu Lys Gly Ala Asp Asn Leu Thr Glu Ile 
            340                 345                 350         


Lys Arg Glu Gly Asn Leu Ile Cys Pro Val Leu Phe Asp Lys Val Thr 
        355                 360                 365             


Thr Asp Met Arg Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Ile Ile Arg Val Lys Ser Val Glu Glu Ala Ile Ala Ile Ser Asn Gln 
385                 390                 395                 400 


Ser Glu Tyr Gly Leu Gln Ala Ser Ile Phe Thr Asn Asp Phe Pro Arg 
                405                 410                 415     


Ala Phe Gly Ile Ala Glu Gln Leu Glu Val Gly Thr Val His Leu Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Thr Asp Asn Phe Pro Phe Leu Gly Ala Lys 
        435                 440                 445             


Lys Ser Gly Ala Gly Ile Gln Gly Val Lys Tyr Ser Ile Glu Ala Met 
    450                 455                 460                 


Thr Thr Val Lys Ser Val Val Phe Asp Ile Lys 
465                 470                 475 


<210>  52
<211>  1431
<212>  DNA
<213>  Streptococcus hyointestinalis

<400>  52
atgaccaagg cttacaagaa ctacgttaat ggtgaatgga agctgtccga agaatccatt       60

gaaatttttg ctccagctac cggtgaatct ttgggtactg ttccagctat gactactgct      120

gaagttgatg aagtttacgc taaagctaaa gctgctcaac cagcttggag agctttgtct      180

tatgttgaaa gagctgctta cttgcataag gttgccgata ttttggttag agatgccgaa      240

aaaattggtg ccgtcttgtc taaagaaatt gctaagggtt acaagtccgc cgtttctgaa      300

gttattagaa ccgctgaaat tatcaactac gctgctgaag agggtttgag aatggaaggt      360

gaagttttgg aaggtggttc ttttgaagct gcttccaaaa acaagattgc catcgttaga      420

agagaaccag ttggtttggt tttggctatt tctccattca actacccaat caatttggcc      480

ggttctaaaa ttgctcctgc tttgatttct ggtaacgttg ttgctttgaa accaccaact      540

caaggttcta tttctggttt gttgttggct gaagcttttg ctgaagctgg tttgccagct      600

ggtgttttta acactattac tggtagaggt tccgttatcg gtgattacat cgttgaacat      660

gaagccgtca atttcattaa cttcactggt tctactccaa tcggtgaaag aattggtaaa      720

ttggctggta tgaggccaat catgttggaa ttaggtggta aagattccgc cattgtcttg      780

gaagatgctg atttggattt gaccgccaag aacattattg ctggtgcttt tggttattcc      840

ggtcaaagat gtactgctgt taagagggta ttagttatgg attccgttgc cgatgaattg      900

gtcgaaaaga ttagacaaca agtcttggac ttgaccattg gtaatcctga agatgatgct      960

gatattaccc cattgattga taagaatgct gccgattttg tcgaaggttt gattaacgat     1020

gcttctgata agggtgcaga agctttgact gaaatcaaga gagaaggtaa cttgatctgc     1080

ccagttttgt tcgataaggt tactaccgat atgagattgg cttgggaaga accatttggt     1140

ccagttttgc caattatcag agttaagtct gttgaagaag ccatcgagat ctctaacaaa     1200

tccgaatatg gtctgcaagc ttctgttttc actaacaatt ttccactggc cttcaagatc     1260

gcttctcaat tggaagttgg tactgtccat attaacaaca agacccaaag aggtactgac     1320

aactttccat ttttgggtgc taaaaaatca ggtgctggtg ttcaaggtgt taagtactct     1380

attgaagcta tgacctctgt caagtccgtt gtttttgata ttgccaagta a              1431


<210>  53
<211>  476
<212>  PRT
<213>  Streptococcus hyointestinalis

<400>  53

Met Thr Lys Ala Tyr Lys Asn Tyr Val Asn Gly Glu Trp Lys Leu Ser 
1               5                   10                  15      


Glu Glu Ser Ile Glu Ile Phe Ala Pro Ala Thr Gly Glu Ser Leu Gly 
            20                  25                  30          


Thr Val Pro Ala Met Thr Thr Ala Glu Val Asp Glu Val Tyr Ala Lys 
        35                  40                  45              


Ala Lys Ala Ala Gln Pro Ala Trp Arg Ala Leu Ser Tyr Val Glu Arg 
    50                  55                  60                  


Ala Ala Tyr Leu His Lys Val Ala Asp Ile Leu Val Arg Asp Ala Glu 
65                  70                  75                  80  


Lys Ile Gly Ala Val Leu Ser Lys Glu Ile Ala Lys Gly Tyr Lys Ser 
                85                  90                  95      


Ala Val Ser Glu Val Ile Arg Thr Ala Glu Ile Ile Asn Tyr Ala Ala 
            100                 105                 110         


Glu Glu Gly Leu Arg Met Glu Gly Glu Val Leu Glu Gly Gly Ser Phe 
        115                 120                 125             


Glu Ala Ala Ser Lys Asn Lys Ile Ala Ile Val Arg Arg Glu Pro Val 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Ile Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Ile Ser Gly Asn Val Val Ala Leu 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Leu Leu Ala Glu Ala 
            180                 185                 190         


Phe Ala Glu Ala Gly Leu Pro Ala Gly Val Phe Asn Thr Ile Thr Gly 
        195                 200                 205             


Arg Gly Ser Val Ile Gly Asp Tyr Ile Val Glu His Glu Ala Val Asn 
    210                 215                 220                 


Phe Ile Asn Phe Thr Gly Ser Thr Pro Ile Gly Glu Arg Ile Gly Lys 
225                 230                 235                 240 


Leu Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ser 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Asp Leu Thr Ala Lys Asn Ile 
            260                 265                 270         


Ile Ala Gly Ala Phe Gly Tyr Ser Gly Gln Arg Cys Thr Ala Val Lys 
        275                 280                 285             


Arg Val Leu Val Met Asp Ser Val Ala Asp Glu Leu Val Glu Lys Ile 
    290                 295                 300                 


Arg Gln Gln Val Leu Asp Leu Thr Ile Gly Asn Pro Glu Asp Asp Ala 
305                 310                 315                 320 


Asp Ile Thr Pro Leu Ile Asp Lys Asn Ala Ala Asp Phe Val Glu Gly 
                325                 330                 335     


Leu Ile Asn Asp Ala Ser Asp Lys Gly Ala Glu Ala Leu Thr Glu Ile 
            340                 345                 350         


Lys Arg Glu Gly Asn Leu Ile Cys Pro Val Leu Phe Asp Lys Val Thr 
        355                 360                 365             


Thr Asp Met Arg Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Ile Ile Arg Val Lys Ser Val Glu Glu Ala Ile Glu Ile Ser Asn Lys 
385                 390                 395                 400 


Ser Glu Tyr Gly Leu Gln Ala Ser Val Phe Thr Asn Asn Phe Pro Leu 
                405                 410                 415     


Ala Phe Lys Ile Ala Ser Gln Leu Glu Val Gly Thr Val His Ile Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Thr Asp Asn Phe Pro Phe Leu Gly Ala Lys 
        435                 440                 445             


Lys Ser Gly Ala Gly Val Gln Gly Val Lys Tyr Ser Ile Glu Ala Met 
    450                 455                 460                 


Thr Ser Val Lys Ser Val Val Phe Asp Ile Ala Lys 
465                 470                 475     


<210>  54
<211>  1428
<212>  DNA
<213>  Streptococcus urinalis

<400>  54
atgaccaagc agtacaagaa ctacgttaat ggtgaatgga agttgtccga aaacgagatt       60

aagatatatg ctccagcttc cggtgaagaa ttgggttctg ttccagctat gactcaagct      120

gaagttgatg atgtttacgc ttctgctaaa gctgctttgc cagcttggag agctttgtct      180

tatgttgaaa gagctaacta cttgcataag gccgctgata ttttggttag agatgctgaa      240

aagatcggct ccgttttgtc tcaagaagtt gctaaaggtc ataagtccgc tgtttccgaa      300

gttattagaa ccgctgaaat tatcaactac gctgctgaag agggtttgag aatggaaggt      360

gaagttttgg aaggtggttc ttttgaagct gcttccaaaa agaagattgc catcgttaga      420

agagaaccag ttggtttggt tttggctatt tctccattca actacccagt taatttggcc      480

ggttctaaaa ttgctccagc attgattgct ggtaacgttg ttgctttgaa accaccaact      540

caaggttcca tttctggtat tttgttggct caagcttttg ctgaagctgg tattccagct      600

ggtgttttca acactattac tggtagaggt tccgttatcg gtgattacat cgttgaacat      660

gaagccgtta acttcatcaa tttcactggt tctactccag tcggtgaaag aataggtaaa      720

ttggctggta tgaggccaat catgttggaa ttaggtggta aagattccgc cattgtcttg      780

gaagatgctg atttggatgt tgctgctaag aatatcgttg ctggtgcttt tggttattct      840

ggtcaaagat gtactgctgt taagcgtgtt ttggtcatgg attctgttgc tgatgcattg      900

gttgaaaagg tgtctcaaaa ggtttctgct ttgactattg gtaaccctga agatgatgct      960

gatattaccc cattgattga taccaaggct gctgattttg ttgaaggttt gattaacgac     1020

gccaaagaaa aaggtgcaca accattgcac gaaatcaaga gagaaggtaa tttggtttgc     1080

ccattggttt tcgataaggt tactaccgat atgagattgg cttgggaaga accatttggt     1140

ccagttttgc ctttcatcag agttaagtct gttgaagaag ccatcaagat ctccaacgaa     1200

tctgaatatg gtctgcaagc ttctgttttc actaacaatt ttccaagagc tttcgccatt     1260

gccgaacaat tggaagttgg tactgttcac attaacaaca agacccaaag aggtactgat     1320

aactttccat ttttgggcgc taaaaaatct ggtgctggtg ttcaaggtgt taagtactct     1380

attgaagcta tgacctctgt caagtccgtt gtttttgata tcgagtaa                  1428


<210>  55
<211>  475
<212>  PRT
<213>  Streptococcus urinalis

<400>  55

Met Thr Lys Gln Tyr Lys Asn Tyr Val Asn Gly Glu Trp Lys Leu Ser 
1               5                   10                  15      


Glu Asn Glu Ile Lys Ile Tyr Ala Pro Ala Ser Gly Glu Glu Leu Gly 
            20                  25                  30          


Ser Val Pro Ala Met Thr Gln Ala Glu Val Asp Asp Val Tyr Ala Ser 
        35                  40                  45              


Ala Lys Ala Ala Leu Pro Ala Trp Arg Ala Leu Ser Tyr Val Glu Arg 
    50                  55                  60                  


Ala Asn Tyr Leu His Lys Ala Ala Asp Ile Leu Val Arg Asp Ala Glu 
65                  70                  75                  80  


Lys Ile Gly Ser Val Leu Ser Gln Glu Val Ala Lys Gly His Lys Ser 
                85                  90                  95      


Ala Val Ser Glu Val Ile Arg Thr Ala Glu Ile Ile Asn Tyr Ala Ala 
            100                 105                 110         


Glu Glu Gly Leu Arg Met Glu Gly Glu Val Leu Glu Gly Gly Ser Phe 
        115                 120                 125             


Glu Ala Ala Ser Lys Lys Lys Ile Ala Ile Val Arg Arg Glu Pro Val 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Val Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Ile Ala Gly Asn Val Val Ala Leu 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Ile Leu Leu Ala Gln Ala 
            180                 185                 190         


Phe Ala Glu Ala Gly Ile Pro Ala Gly Val Phe Asn Thr Ile Thr Gly 
        195                 200                 205             


Arg Gly Ser Val Ile Gly Asp Tyr Ile Val Glu His Glu Ala Val Asn 
    210                 215                 220                 


Phe Ile Asn Phe Thr Gly Ser Thr Pro Val Gly Glu Arg Ile Gly Lys 
225                 230                 235                 240 


Leu Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ser 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Asp Val Ala Ala Lys Asn Ile 
            260                 265                 270         


Val Ala Gly Ala Phe Gly Tyr Ser Gly Gln Arg Cys Thr Ala Val Lys 
        275                 280                 285             


Arg Val Leu Val Met Asp Ser Val Ala Asp Ala Leu Val Glu Lys Val 
    290                 295                 300                 


Ser Gln Lys Val Ser Ala Leu Thr Ile Gly Asn Pro Glu Asp Asp Ala 
305                 310                 315                 320 


Asp Ile Thr Pro Leu Ile Asp Thr Lys Ala Ala Asp Phe Val Glu Gly 
                325                 330                 335     


Leu Ile Asn Asp Ala Lys Glu Lys Gly Ala Gln Pro Leu His Glu Ile 
            340                 345                 350         


Lys Arg Glu Gly Asn Leu Val Cys Pro Leu Val Phe Asp Lys Val Thr 
        355                 360                 365             


Thr Asp Met Arg Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Phe Ile Arg Val Lys Ser Val Glu Glu Ala Ile Lys Ile Ser Asn Glu 
385                 390                 395                 400 


Ser Glu Tyr Gly Leu Gln Ala Ser Val Phe Thr Asn Asn Phe Pro Arg 
                405                 410                 415     


Ala Phe Ala Ile Ala Glu Gln Leu Glu Val Gly Thr Val His Ile Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Thr Asp Asn Phe Pro Phe Leu Gly Ala Lys 
        435                 440                 445             


Lys Ser Gly Ala Gly Val Gln Gly Val Lys Tyr Ser Ile Glu Ala Met 
    450                 455                 460                 


Thr Ser Val Lys Ser Val Val Phe Asp Ile Glu 
465                 470                 475 


<210>  56
<211>  1428
<212>  DNA
<213>  Streptococcus canis

<400>  56
atgactaccc agtacaagaa cttggttaat ggtgaatgga agttgtccga aaacgagatt       60

aagatatatg ctccagctac cggtgaagaa ttgggttctg ttccagctat gtctagagaa      120

gaggttgatg ctgtttatgg tgctgctaga caagctttgg ctggttggag agctttgtct      180

tatgttgaaa gagctgcttt cttgcataag gctgctgata ttttggttag agatgccgaa      240

aagattggtg ccatcttgtc taaagaagtt gctaaaggtc acaaagctgc cgtttctgaa      300

gttattagaa ccgccgaaat tatcaactat gctgctgaag agggtttgag aatggaaggt      360

gaagttttgg aaggtggttc ttttgaagct gcttccaaaa aaaagatcgc catcgttaga      420

agagaaccag ttggtttggt tttggctatt tctccattca attacccagt taatttggcc      480

ggttcaaaaa ttgctccagc attgattgct ggtaacgttg ttgctttgaa accaccaact      540

caaggttcta tttctggttt gttgttggct gaagcttttg ctgaagctgg tattccagct      600

ggtgttttca acactattac tggtagaggt tccgttatcg gtgattacat cgttgaacat      660

gaagccgtta acttcatcaa cttcactggt tctactccaa tcggtgaaag aataggtaaa      720

ttggctggta tgaggccaat catgttggaa ttaggtggta aagattccgc cattgtcttg      780

gaagatgctg atttggattt ggctgctaag aatatcgttg ctggtgcttt tggttattct      840

ggtcaaagat gtactgctgt taagcgtgtt ttggtcatgg aatctgttgc tgatgatttg      900

gtcgaaaaga tcagagataa ggtcttgcaa ttgaccattg gtaaccctga agataacgct      960

gatattaccc ctttgattga tacttctgct gccgattttg ttgagggctt gattaaggat     1020

gctgttgata agggtgctac tgctcatact gatattaaga gagaaggtaa cttgatctgc     1080

ccaatcttgt tcgatcatgt tactaccgat atgagattgg cttgggaaga accatttggt     1140

ccagttttgc caattattag agttgcctct gttgaagaag ccatcaagat ttctaacgaa     1200

tctgaatacg gtctgcaagc ctctattttt actaccaatt ttccacaagc tttcggtatc     1260

gctgaacaat tggaagttgg tactgttcac attaacaaca agacccaaag aggtactgat     1320

aactttccat ttttgggcgc taaaaaatct ggtgctggtg ttcaaggtgt taagtactct     1380

attgaagcta tgacctccgt taagtccgtt gttttcgata tccaatga                  1428


<210>  57
<211>  475
<212>  PRT
<213>  Streptococcus canis

<400>  57

Met Thr Thr Gln Tyr Lys Asn Leu Val Asn Gly Glu Trp Lys Leu Ser 
1               5                   10                  15      


Glu Asn Glu Ile Lys Ile Tyr Ala Pro Ala Thr Gly Glu Glu Leu Gly 
            20                  25                  30          


Ser Val Pro Ala Met Ser Arg Glu Glu Val Asp Ala Val Tyr Gly Ala 
        35                  40                  45              


Ala Arg Gln Ala Leu Ala Gly Trp Arg Ala Leu Ser Tyr Val Glu Arg 
    50                  55                  60                  


Ala Ala Phe Leu His Lys Ala Ala Asp Ile Leu Val Arg Asp Ala Glu 
65                  70                  75                  80  


Lys Ile Gly Ala Ile Leu Ser Lys Glu Val Ala Lys Gly His Lys Ala 
                85                  90                  95      


Ala Val Ser Glu Val Ile Arg Thr Ala Glu Ile Ile Asn Tyr Ala Ala 
            100                 105                 110         


Glu Glu Gly Leu Arg Met Glu Gly Glu Val Leu Glu Gly Gly Ser Phe 
        115                 120                 125             


Glu Ala Ala Ser Lys Lys Lys Ile Ala Ile Val Arg Arg Glu Pro Val 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Val Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Ile Ala Gly Asn Val Val Ala Leu 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Leu Leu Ala Glu Ala 
            180                 185                 190         


Phe Ala Glu Ala Gly Ile Pro Ala Gly Val Phe Asn Thr Ile Thr Gly 
        195                 200                 205             


Arg Gly Ser Val Ile Gly Asp Tyr Ile Val Glu His Glu Ala Val Asn 
    210                 215                 220                 


Phe Ile Asn Phe Thr Gly Ser Thr Pro Ile Gly Glu Arg Ile Gly Lys 
225                 230                 235                 240 


Leu Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ser 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Asp Leu Ala Ala Lys Asn Ile 
            260                 265                 270         


Val Ala Gly Ala Phe Gly Tyr Ser Gly Gln Arg Cys Thr Ala Val Lys 
        275                 280                 285             


Arg Val Leu Val Met Glu Ser Val Ala Asp Asp Leu Val Glu Lys Ile 
    290                 295                 300                 


Arg Asp Lys Val Leu Gln Leu Thr Ile Gly Asn Pro Glu Asp Asn Ala 
305                 310                 315                 320 


Asp Ile Thr Pro Leu Ile Asp Thr Ser Ala Ala Asp Phe Val Glu Gly 
                325                 330                 335     


Leu Ile Lys Asp Ala Val Asp Lys Gly Ala Thr Ala His Thr Asp Ile 
            340                 345                 350         


Lys Arg Glu Gly Asn Leu Ile Cys Pro Ile Leu Phe Asp His Val Thr 
        355                 360                 365             


Thr Asp Met Arg Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Ile Ile Arg Val Ala Ser Val Glu Glu Ala Ile Lys Ile Ser Asn Glu 
385                 390                 395                 400 


Ser Glu Tyr Gly Leu Gln Ala Ser Ile Phe Thr Thr Asn Phe Pro Gln 
                405                 410                 415     


Ala Phe Gly Ile Ala Glu Gln Leu Glu Val Gly Thr Val His Ile Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Thr Asp Asn Phe Pro Phe Leu Gly Ala Lys 
        435                 440                 445             


Lys Ser Gly Ala Gly Val Gln Gly Val Lys Tyr Ser Ile Glu Ala Met 
    450                 455                 460                 


Thr Ser Val Lys Ser Val Val Phe Asp Ile Gln 
465                 470                 475 


<210>  58
<211>  1428
<212>  DNA
<213>  Streptococcus thoraltensis

<400>  58
atgtccaagc agtacaagaa cttggttaat ggtgaatgga agttgtccga caacgaaatc       60

aaaatctatg ctccagctac tggtgaagaa ttgggttctg ttccagctat gtctcaagaa      120

gaggttgatt acgtttacga aactgctaaa gctgctcaac cagcttggag agctttgtct      180

tatgttgaaa gagctgctta cttgcataag gttgccgata ttttggatag agatgccgaa      240

aagattggtg aggtcttgtc taaagaaatt gccaaaggtt acaaggctgc cgtttctgaa      300

gttactagaa ctgctgatat tatcagatac gctgctgaag agggtgttag aatgcaaggt      360

gaagttttgg aaggtggttc ttttgatgct gcctccaaaa aaaagattgc catggttaga      420

agagagccat tgggtttagt tttggctatt tctccattca actacccagt taatttggcc      480

ggttctaaaa ttgctccagc attgatttct ggtaacgttg ttgctttgaa accaccaact      540

caaggttcta tttctggttt ggttttagct gaagttttcg ctgaagctgg tattccagct      600

ggtgtttttt ctactattac tggtagaggt tccgttatcg gtgattacat cgttgaacat      660

gaagccgtta acttcatcaa cttcactggt tctactccag ttggtgaaag aataggtaaa      720

atggctggta tgaggccaat catgttggaa ttaggtggta aagattccgc cattgtcttg      780

gaagatgctg atttggaagt tgctgctaag aatatcgttg atggtgcttt tggttactct      840

ggtcaaagat gtactgctgt taagcgtgtt ttggttatgg attctgttgc cgatgaattg      900

gtcgaaatgt tgagagaaaa ggtcttgaag ttgactgttg gtaaccctga agataacgca      960

gatattaccc cattgattga tactgctgct gccgattttg ttgaaggttt agttaatgat     1020

gccgttgaaa aaggtgctga tgctaagact gatatcttga gagaaggtaa cttgatctac     1080

ccaatcttgt tcgataacgt tactaccgat atgaagttgg cttgggaaga accatttggt     1140

ccagttttgc cagttatcag agtttcctct gttgaagaag ccatcgaaat ctctaacaaa     1200

tctgaatacg gtctgcaagc ttccgttttc actaatgatt ttccattggc tttctctatc     1260

gccgaacaat tagaagttgg tactgttcac attaacaaca agacccaaag aggtactgat     1320

aactttccat ttttgggcgc taaaaaatct ggtgctggta ctcaaggtgt taagtactct     1380

attgaagcta tgaccaccgt taagtccgtt gttttcgata tcaagtaa                  1428


<210>  59
<211>  475
<212>  PRT
<213>  Streptococcus thoraltensis

<400>  59

Met Ser Lys Gln Tyr Lys Asn Leu Val Asn Gly Glu Trp Lys Leu Ser 
1               5                   10                  15      


Asp Asn Glu Ile Lys Ile Tyr Ala Pro Ala Thr Gly Glu Glu Leu Gly 
            20                  25                  30          


Ser Val Pro Ala Met Ser Gln Glu Glu Val Asp Tyr Val Tyr Glu Thr 
        35                  40                  45              


Ala Lys Ala Ala Gln Pro Ala Trp Arg Ala Leu Ser Tyr Val Glu Arg 
    50                  55                  60                  


Ala Ala Tyr Leu His Lys Val Ala Asp Ile Leu Asp Arg Asp Ala Glu 
65                  70                  75                  80  


Lys Ile Gly Glu Val Leu Ser Lys Glu Ile Ala Lys Gly Tyr Lys Ala 
                85                  90                  95      


Ala Val Ser Glu Val Thr Arg Thr Ala Asp Ile Ile Arg Tyr Ala Ala 
            100                 105                 110         


Glu Glu Gly Val Arg Met Gln Gly Glu Val Leu Glu Gly Gly Ser Phe 
        115                 120                 125             


Asp Ala Ala Ser Lys Lys Lys Ile Ala Met Val Arg Arg Glu Pro Leu 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Val Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Ile Ser Gly Asn Val Val Ala Leu 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Val Leu Ala Glu Val 
            180                 185                 190         


Phe Ala Glu Ala Gly Ile Pro Ala Gly Val Phe Ser Thr Ile Thr Gly 
        195                 200                 205             


Arg Gly Ser Val Ile Gly Asp Tyr Ile Val Glu His Glu Ala Val Asn 
    210                 215                 220                 


Phe Ile Asn Phe Thr Gly Ser Thr Pro Val Gly Glu Arg Ile Gly Lys 
225                 230                 235                 240 


Met Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ser 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Glu Val Ala Ala Lys Asn Ile 
            260                 265                 270         


Val Asp Gly Ala Phe Gly Tyr Ser Gly Gln Arg Cys Thr Ala Val Lys 
        275                 280                 285             


Arg Val Leu Val Met Asp Ser Val Ala Asp Glu Leu Val Glu Met Leu 
    290                 295                 300                 


Arg Glu Lys Val Leu Lys Leu Thr Val Gly Asn Pro Glu Asp Asn Ala 
305                 310                 315                 320 


Asp Ile Thr Pro Leu Ile Asp Thr Ala Ala Ala Asp Phe Val Glu Gly 
                325                 330                 335     


Leu Val Asn Asp Ala Val Glu Lys Gly Ala Asp Ala Lys Thr Asp Ile 
            340                 345                 350         


Leu Arg Glu Gly Asn Leu Ile Tyr Pro Ile Leu Phe Asp Asn Val Thr 
        355                 360                 365             


Thr Asp Met Lys Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Val Ile Arg Val Ser Ser Val Glu Glu Ala Ile Glu Ile Ser Asn Lys 
385                 390                 395                 400 


Ser Glu Tyr Gly Leu Gln Ala Ser Val Phe Thr Asn Asp Phe Pro Leu 
                405                 410                 415     


Ala Phe Ser Ile Ala Glu Gln Leu Glu Val Gly Thr Val His Ile Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Thr Asp Asn Phe Pro Phe Leu Gly Ala Lys 
        435                 440                 445             


Lys Ser Gly Ala Gly Thr Gln Gly Val Lys Tyr Ser Ile Glu Ala Met 
    450                 455                 460                 


Thr Thr Val Lys Ser Val Val Phe Asp Ile Lys 
465                 470                 475 


<210>  60
<211>  1428
<212>  DNA
<213>  Streptococcus dysgalactiae

<400>  60
atgactaccc agtacaagaa cttggttaat ggtgattgga agttgtccga atccgatatt       60

aagatatatg ctccagctac cggtgaagaa ttgggttctg ttccagctat gactcaagct      120

gaagttgatg ctgtttatgc ttctgctaaa aaagctttgc cagcttggag agctttgtct      180

tatgttgaaa gagctgctta cttgcataag gctgctgata ttttggttag agatgccgaa      240

aaaattggtg ccgtcttgtc taaagaagtt gctaaaggtc acaaagctgc cgtttctgaa      300

gttattagaa ccgccgaaat tatcaactat gctgctgaag agggtttgag aatggaaggt      360

gaagttttgg aaggtggttc ttttgaagct gcttccaaaa aaaagatcgc catcgttaga      420

agagaaccag ttggtttggt tttggctatt tctccattca attacccagt taacttggcc      480

ggttctaaaa ttgctccagc attgattgct ggtaacgttg ttgctttgaa accaccaact      540

caaggttcta tttctggttt gttgttggct gaagcttttg ctgaagctgg tattccagct      600

ggtgttttca acactattac tggtagaggt tccgttatcg gtgattacat cgttgaacat      660

gaagccgtta acttcatcaa tttcactggt tctactccaa tcggtgaagg tattggtaaa      720

ttggctggta tgaggccaat catgttggaa ttaggtggta aagattccgc cattgtcttg      780

gaagatgctg atttggcttt ggctgctaag aatatcgttg ctggtgcttt tggttattct      840

ggtcaaagat gtactgctgt taagcgtgtt ttggtcatgg ataaggttgc agatcaattg      900

gctgctgaaa tcaagacttt ggtcgaaaaa ttgtctgtcg gtatgcctga agatgatgca      960

gatattactc cattgattga taccaaggct gccgattttg ttgaaggttt gattaaggat     1020

gctgcagata agggtgctac tgctttgact acttttaaca gagaaggcaa cttgatctcc     1080

ccagttttgt ttgatcatgt taccaccgat atgagattgg cttgggaaga accatttggt     1140

ccagttttgc caattatcag agttacctct gttgaagaag ccatcgaaat ttctaacgct     1200

tccgaatatg gtctgcaagc ttctattttc actaacaact ttccaaaggc tttcggtatt     1260

gccgaacaat tagaagttgg tactgttcac ttgaacaaca agactcaaag aggtacagat     1320

aacttcccat ttttgggtgc taaaaagtct ggtgctggtg ttcaaggtgt taagtattct     1380

attgaagcta tgaccaccgt taagtccgtt gttttcgata tccaatga                  1428


<210>  61
<211>  475
<212>  PRT
<213>  Streptococcus dysgalactiae

<400>  61

Met Thr Thr Gln Tyr Lys Asn Leu Val Asn Gly Asp Trp Lys Leu Ser 
1               5                   10                  15      


Glu Ser Asp Ile Lys Ile Tyr Ala Pro Ala Thr Gly Glu Glu Leu Gly 
            20                  25                  30          


Ser Val Pro Ala Met Thr Gln Ala Glu Val Asp Ala Val Tyr Ala Ser 
        35                  40                  45              


Ala Lys Lys Ala Leu Pro Ala Trp Arg Ala Leu Ser Tyr Val Glu Arg 
    50                  55                  60                  


Ala Ala Tyr Leu His Lys Ala Ala Asp Ile Leu Val Arg Asp Ala Glu 
65                  70                  75                  80  


Lys Ile Gly Ala Val Leu Ser Lys Glu Val Ala Lys Gly His Lys Ala 
                85                  90                  95      


Ala Val Ser Glu Val Ile Arg Thr Ala Glu Ile Ile Asn Tyr Ala Ala 
            100                 105                 110         


Glu Glu Gly Leu Arg Met Glu Gly Glu Val Leu Glu Gly Gly Ser Phe 
        115                 120                 125             


Glu Ala Ala Ser Lys Lys Lys Ile Ala Ile Val Arg Arg Glu Pro Val 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Val Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Ile Ala Gly Asn Val Val Ala Leu 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Leu Leu Ala Glu Ala 
            180                 185                 190         


Phe Ala Glu Ala Gly Ile Pro Ala Gly Val Phe Asn Thr Ile Thr Gly 
        195                 200                 205             


Arg Gly Ser Val Ile Gly Asp Tyr Ile Val Glu His Glu Ala Val Asn 
    210                 215                 220                 


Phe Ile Asn Phe Thr Gly Ser Thr Pro Ile Gly Glu Gly Ile Gly Lys 
225                 230                 235                 240 


Leu Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ser 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Ala Leu Ala Ala Lys Asn Ile 
            260                 265                 270         


Val Ala Gly Ala Phe Gly Tyr Ser Gly Gln Arg Cys Thr Ala Val Lys 
        275                 280                 285             


Arg Val Leu Val Met Asp Lys Val Ala Asp Gln Leu Ala Ala Glu Ile 
    290                 295                 300                 


Lys Thr Leu Val Glu Lys Leu Ser Val Gly Met Pro Glu Asp Asp Ala 
305                 310                 315                 320 


Asp Ile Thr Pro Leu Ile Asp Thr Lys Ala Ala Asp Phe Val Glu Gly 
                325                 330                 335     


Leu Ile Lys Asp Ala Ala Asp Lys Gly Ala Thr Ala Leu Thr Thr Phe 
            340                 345                 350         


Asn Arg Glu Gly Asn Leu Ile Ser Pro Val Leu Phe Asp His Val Thr 
        355                 360                 365             


Thr Asp Met Arg Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Ile Ile Arg Val Thr Ser Val Glu Glu Ala Ile Glu Ile Ser Asn Ala 
385                 390                 395                 400 


Ser Glu Tyr Gly Leu Gln Ala Ser Ile Phe Thr Asn Asn Phe Pro Lys 
                405                 410                 415     


Ala Phe Gly Ile Ala Glu Gln Leu Glu Val Gly Thr Val His Leu Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Thr Asp Asn Phe Pro Phe Leu Gly Ala Lys 
        435                 440                 445             


Lys Ser Gly Ala Gly Val Gln Gly Val Lys Tyr Ser Ile Glu Ala Met 
    450                 455                 460                 


Thr Thr Val Lys Ser Val Val Phe Asp Ile Gln 
465                 470                 475 


<210>  62
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated tsl1 promoter

<400>  62
tctttcgatc actaccatgt ctgtttaacc gagcaacgcg ttcctccgga gccgatggta       60

ctggctccgg agaagggtcg ttggtggcat ccgagggcgc cggtttggca tcatgttcgg      120

ttcgcgaggg tacttgcttg gcgcccctgt gtttcacggt gtaaacaaac aagcacacca      180

tcgccagtat aaacactata gtcgatccat ccatttttac ttttgtgcgc gtaggtagcc      240

gtgcctcgcc tgtgtgtgtg ggaatgtcta aatgtgtccc gagttattgt tctaaagcgg      300

gcaccattgt agtaacttat tgcgaaattt ctgctcttct cgtctcgctc aaaaatcgcg      360

ttcagggtaa aaggggcgaa acagagggcc agatagaaat ttcgagaaaa gcgggtcacc      420

cccgcccctg cattttgata tggcgtattt gggattgctt gctcgaaagt gtctaagtcc      480

ggctggcggg cctggcgccc tcgccgaagg gagataggaa ggggcggggg tccgggcagc      540

ggctatggtg tcagttacct agggaaggag aagggggtag aaccaagggg ctagcacact      600

caccctgggg ccctcgtcta gccaagctta aatataaata ctaatgtaac tataaatata      660

aggatctacc gtgtcattgc acatccaccc acccgtcgat taaaaaacca aacaaagcaa      720

agaatacaat agcaacgcaa gatcaacaca                                       750


<210>  63
<211>  3297
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  63
atggctctca tcgtggcatc tttgtttttg ccctaccaac cacaattcga gcttgacacc       60

tctctccctg agaactcgca ggtggactca tctctcgtga acatccaggc tatggccaat      120

gaccaacagc aacaacgtgc gctttctaac aacatctcac aggaatcatt ggtcgcgcca      180

gcaccagaac aaggtgtccc accagcaatc tcaaggagtg ccaccaggtc acccagtgct      240

ttcaaccgcg cctcgtctac gacaaatact gccactttag atgatcttgt ctcttcggac      300

atattcatgg aaaacttgac tgcgaatgca actacctcac atacgccaac aagcaagact      360

atacttaaac cccggaaaaa tggttccgtg gaacgattct tctccccttc ttccaatatt      420

cccacggatc gcatcgcatc gccaatccag catgagcatg actccggttc gagaattgct      480

tcgccaatcc aacagcaaca gcaggacccc acggccaact tattaaagaa cgtcaacaag      540

tcattgttag tgcactcact gttgaacaac acctcacaaa ctagcctaga aggacccaac      600

aaccacattg ttaccccgaa atcgagggcg ggcaacaggc ctacttcggc ggctacttct      660

ttagttaata ggaccaaaca aggttcggcc tcctctggat cttctgggtc ttctgcgcca      720

ccttccatta aaaggattac gccccacttg actgcgtccg ctgcaaaaca gcgcccctta      780

ttggctaaac agccttctaa tctgaaatat tcggagttag cagatatttc gtcgagtgag      840

acgtcttcgc agcataatga gtcggacccg gatgatctaa ctactgcccc tgacgaggaa      900

tatgtttctg atttggaaat ggatgacgcg aagcaggact acaaggttcc aaagttcggc      960

ggctattcca ataaatctaa acttaagaag tatgcgctgt taaggtcatc tcaggagctg     1020

tttagccgtc ttccatggtc gatcgttccc tctatcaaag gtaatggcgc catgaagaac     1080

gccataaaca ctgcagtctt ggagaatatc attccgcacc gtcatgttaa gtgggtcggt     1140

accgtcggaa tcccaacgga tgagattccg gaaaatatcc ttgcgaacat ctctgactct     1200

ttaaaagaca agtacgactc ctatcctgtc cttacggacg acgtcacctt caaagccgca     1260

tacaaaaact actgtaaaca aatcttgtgg cctacgctgc attaccagat tccagacaat     1320

ccgaactcga aggcttttga agatcactct tggaagttct atagaaactt aaaccaaagg     1380

tttgcggacg cgatcgttaa aatccataag aaaggtgaca ccatctggat tcatgattac     1440

catttaatgc tggttccgca gatggtgaga gacgtcttgc cttttgccaa aataggattt     1500

accttacatg tctcgttccc cagtagtgaa gtgtttaggt gtctggctca gcgtgagaag     1560

atcttagaag gcttgaccgg tgcagacttt gtcggcttcc agacgaggga gtatgcaaga     1620

catttcttac agacgtctaa ccgtctgcta atggcggacg tggtacatga tgaagagcta     1680

aagtataacg gcagagtcgt ttctgtgagg ttcaccccag ttggtataga cgcctttgat     1740

ttgcaatcgc aattgaagga tggaagtgtc atgcaatggc gtcaattgat tcgtgaaaga     1800

tggcaaggga aaaaactgat tgtgtgtcgt gatcaattcg atagaattag gggtattcac     1860

aagaaattgt tggcttatga aaaatttttg gtcgaaaatc cagaatacgt ggaaaaatcg     1920

actttaattc aaatctgtat tggaagcagt aaggatgtag aactagaacg ccagatcatg     1980

attgttgtgg atagaatcaa ctcgctatcc accaatatta gtatttctca acctgtggtg     2040

tttttacatc aagatctaga tttttctcag tatttagctt tgagttcaga ggcagatttg     2100

ttcgtagtca gctctctaag ggaaggtatg aacttgacat gtcacgaatt tatcgtttgt     2160

tctgaggaca aaaatgctcc cctactgttg tcagaattta ctggtagtgc atctttattg     2220

aatgatggcg ctataataat taacccatgg gataccaaga acttctcaca agccattctc     2280

aaggggttgg agatgccatt cgataagaga agaccacagt ggaagaaatt gatgaaagac     2340

attatcaaca acgactctac aaactggatc aaaacttctt tacaagatat tcatatttcg     2400

tggcaattca atcaagaagg ttccaagatc ttcaaattga atacaaaaac actgatggaa     2460

gattaccagt catctaaaaa gcgtatgttt gttttcaaca ttgctgaacc accttcatcg     2520

agaatgattt ccatactgaa tgacatgact tctaagggca atatcgttta cataatgaac     2580

tcatttccaa agcccattct ggaaaatctt tacagtcggg tgcaaaacat tgggttgatt     2640

gccgaaaatg gtgcatacgt tagtctgaac ggtgtatggt acaacattgt tgatcaagtc     2700

gattggcgta acgatgtagc caaaattctc gaggacaaag tggaaagatt acctggctcg     2760

tactacaaga taaatgagtc catgatcaag ttccacactg aaaatgcgga agatcaagat     2820

cgtgtagcta gtgttatcgg tgatgccatc acacatatca atactgtttt tgaccacagg     2880

ggtattcatg cctacgttta caaaaacgtt gtttccgtac aacaagtggg actttcctta     2940

tcggcagctc aatttctttt cagattctat aattctgctt cagatccact ggatacgagt     3000

tccggccaaa tcacaaatat tcagacacca tctcaacaaa atccttcaga tcaagaacaa     3060

caacctccag cctctcccac tgtgtcgatg aaccatattg atttcgcatg tgtctctggt     3120

tcatcgtctc ctgtgcttga accattgttc aaattggtca atgatgaagc aagtgaaggg     3180

caagtaaaag ccggacacgc cattgtttat ggtgatgcta cttctactta tgccaaagaa     3240

catgtaaatg ggttaaacga acttttcacg atcatttcaa gaatcattga agattaa        3297


<210>  64
<211>  1098
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  64

Met Ala Leu Ile Val Ala Ser Leu Phe Leu Pro Tyr Gln Pro Gln Phe 
1               5                   10                  15      


Glu Leu Asp Thr Ser Leu Pro Glu Asn Ser Gln Val Asp Ser Ser Leu 
            20                  25                  30          


Val Asn Ile Gln Ala Met Ala Asn Asp Gln Gln Gln Gln Arg Ala Leu 
        35                  40                  45              


Ser Asn Asn Ile Ser Gln Glu Ser Leu Val Ala Pro Ala Pro Glu Gln 
    50                  55                  60                  


Gly Val Pro Pro Ala Ile Ser Arg Ser Ala Thr Arg Ser Pro Ser Ala 
65                  70                  75                  80  


Phe Asn Arg Ala Ser Ser Thr Thr Asn Thr Ala Thr Leu Asp Asp Leu 
                85                  90                  95      


Val Ser Ser Asp Ile Phe Met Glu Asn Leu Thr Ala Asn Ala Thr Thr 
            100                 105                 110         


Ser His Thr Pro Thr Ser Lys Thr Ile Leu Lys Pro Arg Lys Asn Gly 
        115                 120                 125             


Ser Val Glu Arg Phe Phe Ser Pro Ser Ser Asn Ile Pro Thr Asp Arg 
    130                 135                 140                 


Ile Ala Ser Pro Ile Gln His Glu His Asp Ser Gly Ser Arg Ile Ala 
145                 150                 155                 160 


Ser Pro Ile Gln Gln Gln Gln Gln Asp Pro Thr Ala Asn Leu Leu Lys 
                165                 170                 175     


Asn Val Asn Lys Ser Leu Leu Val His Ser Leu Leu Asn Asn Thr Ser 
            180                 185                 190         


Gln Thr Ser Leu Glu Gly Pro Asn Asn His Ile Val Thr Pro Lys Ser 
        195                 200                 205             


Arg Ala Gly Asn Arg Pro Thr Ser Ala Ala Thr Ser Leu Val Asn Arg 
    210                 215                 220                 


Thr Lys Gln Gly Ser Ala Ser Ser Gly Ser Ser Gly Ser Ser Ala Pro 
225                 230                 235                 240 


Pro Ser Ile Lys Arg Ile Thr Pro His Leu Thr Ala Ser Ala Ala Lys 
                245                 250                 255     


Gln Arg Pro Leu Leu Ala Lys Gln Pro Ser Asn Leu Lys Tyr Ser Glu 
            260                 265                 270         


Leu Ala Asp Ile Ser Ser Ser Glu Thr Ser Ser Gln His Asn Glu Ser 
        275                 280                 285             


Asp Pro Asp Asp Leu Thr Thr Ala Pro Asp Glu Glu Tyr Val Ser Asp 
    290                 295                 300                 


Leu Glu Met Asp Asp Ala Lys Gln Asp Tyr Lys Val Pro Lys Phe Gly 
305                 310                 315                 320 


Gly Tyr Ser Asn Lys Ser Lys Leu Lys Lys Tyr Ala Leu Leu Arg Ser 
                325                 330                 335     


Ser Gln Glu Leu Phe Ser Arg Leu Pro Trp Ser Ile Val Pro Ser Ile 
            340                 345                 350         


Lys Gly Asn Gly Ala Met Lys Asn Ala Ile Asn Thr Ala Val Leu Glu 
        355                 360                 365             


Asn Ile Ile Pro His Arg His Val Lys Trp Val Gly Thr Val Gly Ile 
    370                 375                 380                 


Pro Thr Asp Glu Ile Pro Glu Asn Ile Leu Ala Asn Ile Ser Asp Ser 
385                 390                 395                 400 


Leu Lys Asp Lys Tyr Asp Ser Tyr Pro Val Leu Thr Asp Asp Val Thr 
                405                 410                 415     


Phe Lys Ala Ala Tyr Lys Asn Tyr Cys Lys Gln Ile Leu Trp Pro Thr 
            420                 425                 430         


Leu His Tyr Gln Ile Pro Asp Asn Pro Asn Ser Lys Ala Phe Glu Asp 
        435                 440                 445             


His Ser Trp Lys Phe Tyr Arg Asn Leu Asn Gln Arg Phe Ala Asp Ala 
    450                 455                 460                 


Ile Val Lys Ile His Lys Lys Gly Asp Thr Ile Trp Ile His Asp Tyr 
465                 470                 475                 480 


His Leu Met Leu Val Pro Gln Met Val Arg Asp Val Leu Pro Phe Ala 
                485                 490                 495     


Lys Ile Gly Phe Thr Leu His Val Ser Phe Pro Ser Ser Glu Val Phe 
            500                 505                 510         


Arg Cys Leu Ala Gln Arg Glu Lys Ile Leu Glu Gly Leu Thr Gly Ala 
        515                 520                 525             


Asp Phe Val Gly Phe Gln Thr Arg Glu Tyr Ala Arg His Phe Leu Gln 
    530                 535                 540                 


Thr Ser Asn Arg Leu Leu Met Ala Asp Val Val His Asp Glu Glu Leu 
545                 550                 555                 560 


Lys Tyr Asn Gly Arg Val Val Ser Val Arg Phe Thr Pro Val Gly Ile 
                565                 570                 575     


Asp Ala Phe Asp Leu Gln Ser Gln Leu Lys Asp Gly Ser Val Met Gln 
            580                 585                 590         


Trp Arg Gln Leu Ile Arg Glu Arg Trp Gln Gly Lys Lys Leu Ile Val 
        595                 600                 605             


Cys Arg Asp Gln Phe Asp Arg Ile Arg Gly Ile His Lys Lys Leu Leu 
    610                 615                 620                 


Ala Tyr Glu Lys Phe Leu Val Glu Asn Pro Glu Tyr Val Glu Lys Ser 
625                 630                 635                 640 


Thr Leu Ile Gln Ile Cys Ile Gly Ser Ser Lys Asp Val Glu Leu Glu 
                645                 650                 655     


Arg Gln Ile Met Ile Val Val Asp Arg Ile Asn Ser Leu Ser Thr Asn 
            660                 665                 670         


Ile Ser Ile Ser Gln Pro Val Val Phe Leu His Gln Asp Leu Asp Phe 
        675                 680                 685             


Ser Gln Tyr Leu Ala Leu Ser Ser Glu Ala Asp Leu Phe Val Val Ser 
    690                 695                 700                 


Ser Leu Arg Glu Gly Met Asn Leu Thr Cys His Glu Phe Ile Val Cys 
705                 710                 715                 720 


Ser Glu Asp Lys Asn Ala Pro Leu Leu Leu Ser Glu Phe Thr Gly Ser 
                725                 730                 735     


Ala Ser Leu Leu Asn Asp Gly Ala Ile Ile Ile Asn Pro Trp Asp Thr 
            740                 745                 750         


Lys Asn Phe Ser Gln Ala Ile Leu Lys Gly Leu Glu Met Pro Phe Asp 
        755                 760                 765             


Lys Arg Arg Pro Gln Trp Lys Lys Leu Met Lys Asp Ile Ile Asn Asn 
    770                 775                 780                 


Asp Ser Thr Asn Trp Ile Lys Thr Ser Leu Gln Asp Ile His Ile Ser 
785                 790                 795                 800 


Trp Gln Phe Asn Gln Glu Gly Ser Lys Ile Phe Lys Leu Asn Thr Lys 
                805                 810                 815     


Thr Leu Met Glu Asp Tyr Gln Ser Ser Lys Lys Arg Met Phe Val Phe 
            820                 825                 830         


Asn Ile Ala Glu Pro Pro Ser Ser Arg Met Ile Ser Ile Leu Asn Asp 
        835                 840                 845             


Met Thr Ser Lys Gly Asn Ile Val Tyr Ile Met Asn Ser Phe Pro Lys 
    850                 855                 860                 


Pro Ile Leu Glu Asn Leu Tyr Ser Arg Val Gln Asn Ile Gly Leu Ile 
865                 870                 875                 880 


Ala Glu Asn Gly Ala Tyr Val Ser Leu Asn Gly Val Trp Tyr Asn Ile 
                885                 890                 895     


Val Asp Gln Val Asp Trp Arg Asn Asp Val Ala Lys Ile Leu Glu Asp 
            900                 905                 910         


Lys Val Glu Arg Leu Pro Gly Ser Tyr Tyr Lys Ile Asn Glu Ser Met 
        915                 920                 925             


Ile Lys Phe His Thr Glu Asn Ala Glu Asp Gln Asp Arg Val Ala Ser 
    930                 935                 940                 


Val Ile Gly Asp Ala Ile Thr His Ile Asn Thr Val Phe Asp His Arg 
945                 950                 955                 960 


Gly Ile His Ala Tyr Val Tyr Lys Asn Val Val Ser Val Gln Gln Val 
                965                 970                 975     


Gly Leu Ser Leu Ser Ala Ala Gln Phe Leu Phe Arg Phe Tyr Asn Ser 
            980                 985                 990         


Ala Ser Asp Pro Leu Asp Thr Ser  Ser Gly Gln Ile Thr  Asn Ile Gln 
        995                 1000                 1005             


Thr Pro  Ser Gln Gln Asn Pro  Ser Asp Gln Glu Gln  Gln Pro Pro 
    1010                 1015                 1020             


Ala Ser  Pro Thr Val Ser Met  Asn His Ile Asp Phe  Ala Cys Val 
    1025                 1030                 1035             


Ser Gly  Ser Ser Ser Pro Val  Leu Glu Pro Leu Phe  Lys Leu Val 
    1040                 1045                 1050             


Asn Asp  Glu Ala Ser Glu Gly  Gln Val Lys Ala Gly  His Ala Ile 
    1055                 1060                 1065             


Val Tyr  Gly Asp Ala Thr Ser  Thr Tyr Ala Lys Glu  His Val Asn 
    1070                 1075                 1080             


Gly Leu  Asn Glu Leu Phe Thr  Ile Ile Ser Arg Ile  Ile Glu Asp 
    1085                 1090                 1095             


<210>  65
<211>  1083
<212>  DNA
<213>  Entamoeba histolytica

<400>  65
atgaaaggac ttgctatgct tggaattgga agaattggat ggattgaaaa gaaaatccca       60

gaatgtggac cacttgatgc attagttaga ccattagcac ttgcaccatg tacatcagat      120

acacataccg tttgggcagg agctattgga gatagacatg atatgattct tggacatgaa      180

gcggttggac aaattgttaa agttggatca ttagttaaga gattaaaagt tggagataaa      240

gttattgtac cagctattac accagattgg ggagaagaag aatcgcaaag aggatatcca      300

atgcattcag gaggaatgct tggaggatgg aaattctcaa atttcaagga tggagttttt      360

tcagaagttt tccatgttaa tgaagcagat gccaatcttg cacttcttcc aagagatatt      420

aaaccagaag atgcagttat gttatcagat atggtaacta ctggattcca tggagcagaa      480

ttagctaata ttaaacttgg agatactgtt tgtgttattg gtattggacc agttggatta      540

atgtcagttg caggagcaaa ccatcttgga gcaggaagaa tctttgcagt aggatcaaga      600

aaacattgtt gtgatattgc attggaatat ggagcaacag atattattaa ttataaaaat      660

ggagatattg tagaacaaat tcttaaagct acagacggca aaggagttga taaagtcgtt      720

attgcaggag gtgatgttca tacatttgca caagcagtca aaatgattaa accaggatca      780

gatattggaa atgttaatta tcttggagaa ggagataata ttgatattcc aagaagtgaa      840

tggggagttg gaatgggtca taaacacatt catggaggtt taaccccagg tggaagagtc      900

agaatggaaa aattagcatc acttatttca actggtaaat tagatacttc taaacttatt      960

acacatagat ttgaaggatt agaaaaagtt gaagatgcat taatgttaat gaagaataaa     1020

ccagcagacc ttatcaaacc agttgtcaga attcattatg atgatgaaga tactcttcat     1080

taa                                                                   1083


<210>  66
<211>  360
<212>  PRT
<213>  Entamoeba histolytica

<400>  66

Met Lys Gly Leu Ala Met Leu Gly Ile Gly Arg Ile Gly Trp Ile Glu 
1               5                   10                  15      


Lys Lys Ile Pro Glu Cys Gly Pro Leu Asp Ala Leu Val Arg Pro Leu 
            20                  25                  30          


Ala Leu Ala Pro Cys Thr Ser Asp Thr His Thr Val Trp Ala Gly Ala 
        35                  40                  45              


Ile Gly Asp Arg His Asp Met Ile Leu Gly His Glu Ala Val Gly Gln 
    50                  55                  60                  


Ile Val Lys Val Gly Ser Leu Val Lys Arg Leu Lys Val Gly Asp Lys 
65                  70                  75                  80  


Val Ile Val Pro Ala Ile Thr Pro Asp Trp Gly Glu Glu Glu Ser Gln 
                85                  90                  95      


Arg Gly Tyr Pro Met His Ser Gly Gly Met Leu Gly Gly Trp Lys Phe 
            100                 105                 110         


Ser Asn Phe Lys Asp Gly Val Phe Ser Glu Val Phe His Val Asn Glu 
        115                 120                 125             


Ala Asp Ala Asn Leu Ala Leu Leu Pro Arg Asp Ile Lys Pro Glu Asp 
    130                 135                 140                 


Ala Val Met Leu Ser Asp Met Val Thr Thr Gly Phe His Gly Ala Glu 
145                 150                 155                 160 


Leu Ala Asn Ile Lys Leu Gly Asp Thr Val Cys Val Ile Gly Ile Gly 
                165                 170                 175     


Pro Val Gly Leu Met Ser Val Ala Gly Ala Asn His Leu Gly Ala Gly 
            180                 185                 190         


Arg Ile Phe Ala Val Gly Ser Arg Lys His Cys Cys Asp Ile Ala Leu 
        195                 200                 205             


Glu Tyr Gly Ala Thr Asp Ile Ile Asn Tyr Lys Asn Gly Asp Ile Val 
    210                 215                 220                 


Glu Gln Ile Leu Lys Ala Thr Asp Gly Lys Gly Val Asp Lys Val Val 
225                 230                 235                 240 


Ile Ala Gly Gly Asp Val His Thr Phe Ala Gln Ala Val Lys Met Ile 
                245                 250                 255     


Lys Pro Gly Ser Asp Ile Gly Asn Val Asn Tyr Leu Gly Glu Gly Asp 
            260                 265                 270         


Asn Ile Asp Ile Pro Arg Ser Glu Trp Gly Val Gly Met Gly His Lys 
        275                 280                 285             


His Ile His Gly Gly Leu Thr Pro Gly Gly Arg Val Arg Met Glu Lys 
    290                 295                 300                 


Leu Ala Ser Leu Ile Ser Thr Gly Lys Leu Asp Thr Ser Lys Leu Ile 
305                 310                 315                 320 


Thr His Arg Phe Glu Gly Leu Glu Lys Val Glu Asp Ala Leu Met Leu 
                325                 330                 335     


Met Lys Asn Lys Pro Ala Asp Leu Ile Lys Pro Val Val Arg Ile His 
            340                 345                 350         


Tyr Asp Asp Glu Asp Thr Leu His 
        355                 360 


<210>  67
<211>  1101
<212>  DNA
<213>  Entamoeba nuttallii

<400>  67
atggaaggta agactactat gaagggtttg gctatgttgg gtatcggtag aatcggttgg       60

atcgaaaaga agatcccaga atgtggtcca ttggacgctt tggttagacc attggctttg      120

gctccatgta cttctgacac tcacactgtt tgggctggtg ctatcggtga cagacacgac      180

atgatcttgg gtcacgaagc tgttggtcaa atcgttaagg ttggttcttt ggttaagaga      240

ttgaaggttg gtgacaaggt tatcgttcca gctatcactc cagactgggg tgaagaagaa      300

tctcaaagag gttacccaat gcactctggt ggtatgttgg gtggttggaa gttctctaac      360

ttcaaggacg gtgttttctc tgaagttttc cacgttaacg aagctgacgc taacttggct      420

ttgttgccaa gagacatcaa gccagaagac gctgttatgt tgtctgacat ggttactact      480

ggtttccacg gtgctgaatt ggctaacatc aagttgggtg acactgtttg tgttatcggt      540

atcggtccag ttggtttgat gtctgttgct ggtgctaacc acttgggtgc tggtagaatc      600

ttcgctgttg gttctagaaa gcactgttgt gacatcgctt tggaatacgg tgctactgac      660

atcatcaact acaagaacgg tgacatcgtt gaacaaatct tgaaggctac tgacggtaag      720

ggtgttgaca aggttgttat cgctggtggt gacgttcaca ctttcgctca agctgttaag      780

atgatcaagc caggttctga catcggtaac gttaactact tgggtgaagg tgacaacatc      840

gacatcccaa gatctgaatg gggtgttggt atgggtcaca agcacatcca cggtggtttg      900

actccaggtg gtagagttag aatggaaaag ttggcttctt tgatctctac tggtaagttg      960

gacacttcta agttgatcac tcacagattc gaaggtttgg aaaaggttga agacgctttg     1020

atgttgatga agaacaagcc agctgacttg atcaagccag ttgttagaat ccactacgac     1080

gacgaagaca ctttgcacta a                                               1101


<210>  68
<211>  366
<212>  PRT
<213>  Entamoeba nuttallii

<400>  68

Met Glu Gly Lys Thr Thr Met Lys Gly Leu Ala Met Leu Gly Ile Gly 
1               5                   10                  15      


Arg Ile Gly Trp Ile Glu Lys Lys Ile Pro Glu Cys Gly Pro Leu Asp 
            20                  25                  30          


Ala Leu Val Arg Pro Leu Ala Leu Ala Pro Cys Thr Ser Asp Thr His 
        35                  40                  45              


Thr Val Trp Ala Gly Ala Ile Gly Asp Arg His Asp Met Ile Leu Gly 
    50                  55                  60                  


His Glu Ala Val Gly Gln Ile Val Lys Val Gly Ser Leu Val Lys Arg 
65                  70                  75                  80  


Leu Lys Val Gly Asp Lys Val Ile Val Pro Ala Ile Thr Pro Asp Trp 
                85                  90                  95      


Gly Glu Glu Glu Ser Gln Arg Gly Tyr Pro Met His Ser Gly Gly Met 
            100                 105                 110         


Leu Gly Gly Trp Lys Phe Ser Asn Phe Lys Asp Gly Val Phe Ser Glu 
        115                 120                 125             


Val Phe His Val Asn Glu Ala Asp Ala Asn Leu Ala Leu Leu Pro Arg 
    130                 135                 140                 


Asp Ile Lys Pro Glu Asp Ala Val Met Leu Ser Asp Met Val Thr Thr 
145                 150                 155                 160 


Gly Phe His Gly Ala Glu Leu Ala Asn Ile Lys Leu Gly Asp Thr Val 
                165                 170                 175     


Cys Val Ile Gly Ile Gly Pro Val Gly Leu Met Ser Val Ala Gly Ala 
            180                 185                 190         


Asn His Leu Gly Ala Gly Arg Ile Phe Ala Val Gly Ser Arg Lys His 
        195                 200                 205             


Cys Cys Asp Ile Ala Leu Glu Tyr Gly Ala Thr Asp Ile Ile Asn Tyr 
    210                 215                 220                 


Lys Asn Gly Asp Ile Val Glu Gln Ile Leu Lys Ala Thr Asp Gly Lys 
225                 230                 235                 240 


Gly Val Asp Lys Val Val Ile Ala Gly Gly Asp Val His Thr Phe Ala 
                245                 250                 255     


Gln Ala Val Lys Met Ile Lys Pro Gly Ser Asp Ile Gly Asn Val Asn 
            260                 265                 270         


Tyr Leu Gly Glu Gly Asp Asn Ile Asp Ile Pro Arg Ser Glu Trp Gly 
        275                 280                 285             


Val Gly Met Gly His Lys His Ile His Gly Gly Leu Thr Pro Gly Gly 
    290                 295                 300                 


Arg Val Arg Met Glu Lys Leu Ala Ser Leu Ile Ser Thr Gly Lys Leu 
305                 310                 315                 320 


Asp Thr Ser Lys Leu Ile Thr His Arg Phe Glu Gly Leu Glu Lys Val 
                325                 330                 335     


Glu Asp Ala Leu Met Leu Met Lys Asn Lys Pro Ala Asp Leu Ile Lys 
            340                 345                 350         


Pro Val Val Arg Ile His Tyr Asp Asp Glu Asp Thr Leu His 
        355                 360                 365     


<210>  69
<211>  1101
<212>  DNA
<213>  Entamoeba dispar

<400>  69
atggaaggta agactactat gaagggtttg gctatgttgg gtatcggtaa gatcggttgg       60

atcgaaaaga agatcccaga atgtggtcca ttggacgctt tggttagacc attggctttg      120

gctccatgta cttctgacac tcacactgtt tgggctggtg ctatcggtga cagacacgac      180

atgatcttgg gtcacgaagc tgttggtcaa atcgttaagg ttggttcttt ggttaagaga      240

ttgaaggttg gtgacaaggt tatcgttcca gctatcactc cagactgggg tgaagaagaa      300

tctcaaagag gttacccaat gcactctggt ggtatgttgg gtggttggaa gttctctaac      360

ttcaaggacg gtgttttctc tgaaatcttc cacgttaacg aagctgacgc taacttggct      420

ttgttgccaa gagacatcaa ggctgaagac gctgttatgt tgtctgacat ggttactact      480

ggtttccacg gtgctgaatt ggctaacatc aagttgggtg acactgtttg tgttatcggt      540

atcggtccag ttggtttgat gtctgttgct ggtgctaacc acttgggtgc tggtagaatc      600

ttcgctgttg gttctagaaa gcactgttgt gacatcgcta tggaatacgg tgctactgac      660

atcatcaact acaagaacgg tgacatcgtt gaacaaatct tgaaggctac tgacggtaag      720

ggtgttgaca aggttgttat cgctggtggt gacgttcaca ctttcgctca agctgttaag      780

atgatcaagc caggttctga catcggtaac gttaactact tgggtgaagg tgacaacatc      840

gacatcccaa gatctgaatg gggtgttggt atgggtcaca agcacatcca cggtggtttg      900

actccaggtg gtagagttag aatggaaaag ttggcttctt tgatctctac tggtaagttg      960

gacacttcta agttgatcac tcacagattc gaaggtttgg aaaaggttga agacgctttg     1020

atgttgatga agaacaagcc agctgacttg atcaagccag ttgttagaat ccactacgac     1080

gacgaagaca ctttgcacta a                                               1101


<210>  70
<211>  366
<212>  PRT
<213>  Entamoeba dispar

<400>  70

Met Glu Gly Lys Thr Thr Met Lys Gly Leu Ala Met Leu Gly Ile Gly 
1               5                   10                  15      


Lys Ile Gly Trp Ile Glu Lys Lys Ile Pro Glu Cys Gly Pro Leu Asp 
            20                  25                  30          


Ala Leu Val Arg Pro Leu Ala Leu Ala Pro Cys Thr Ser Asp Thr His 
        35                  40                  45              


Thr Val Trp Ala Gly Ala Ile Gly Asp Arg His Asp Met Ile Leu Gly 
    50                  55                  60                  


His Glu Ala Val Gly Gln Ile Val Lys Val Gly Ser Leu Val Lys Arg 
65                  70                  75                  80  


Leu Lys Val Gly Asp Lys Val Ile Val Pro Ala Ile Thr Pro Asp Trp 
                85                  90                  95      


Gly Glu Glu Glu Ser Gln Arg Gly Tyr Pro Met His Ser Gly Gly Met 
            100                 105                 110         


Leu Gly Gly Trp Lys Phe Ser Asn Phe Lys Asp Gly Val Phe Ser Glu 
        115                 120                 125             


Ile Phe His Val Asn Glu Ala Asp Ala Asn Leu Ala Leu Leu Pro Arg 
    130                 135                 140                 


Asp Ile Lys Ala Glu Asp Ala Val Met Leu Ser Asp Met Val Thr Thr 
145                 150                 155                 160 


Gly Phe His Gly Ala Glu Leu Ala Asn Ile Lys Leu Gly Asp Thr Val 
                165                 170                 175     


Cys Val Ile Gly Ile Gly Pro Val Gly Leu Met Ser Val Ala Gly Ala 
            180                 185                 190         


Asn His Leu Gly Ala Gly Arg Ile Phe Ala Val Gly Ser Arg Lys His 
        195                 200                 205             


Cys Cys Asp Ile Ala Met Glu Tyr Gly Ala Thr Asp Ile Ile Asn Tyr 
    210                 215                 220                 


Lys Asn Gly Asp Ile Val Glu Gln Ile Leu Lys Ala Thr Asp Gly Lys 
225                 230                 235                 240 


Gly Val Asp Lys Val Val Ile Ala Gly Gly Asp Val His Thr Phe Ala 
                245                 250                 255     


Gln Ala Val Lys Met Ile Lys Pro Gly Ser Asp Ile Gly Asn Val Asn 
            260                 265                 270         


Tyr Leu Gly Glu Gly Asp Asn Ile Asp Ile Pro Arg Ser Glu Trp Gly 
        275                 280                 285             


Val Gly Met Gly His Lys His Ile His Gly Gly Leu Thr Pro Gly Gly 
    290                 295                 300                 


Arg Val Arg Met Glu Lys Leu Ala Ser Leu Ile Ser Thr Gly Lys Leu 
305                 310                 315                 320 


Asp Thr Ser Lys Leu Ile Thr His Arg Phe Glu Gly Leu Glu Lys Val 
                325                 330                 335     


Glu Asp Ala Leu Met Leu Met Lys Asn Lys Pro Ala Asp Leu Ile Lys 
            340                 345                 350         


Pro Val Val Arg Ile His Tyr Asp Asp Glu Asp Thr Leu His 
        355                 360                 365     


<210>  71
<211>  1428
<212>  DNA
<213>  Streptococcus pyogenes

<400>  71
atggctaagc agtacaagaa cttggttaat ggtgaatgga agttgtccga aaacgaaatt       60

actatctatg ctccagctac cggtgaagaa ttgggttctg ttccagctat gactcaagct      120

gaagttgatg ctgtttatgc ttctgctaaa aaagctttgc cagcttggag agctttgtct      180

tatgttgaaa gagctgctta cttgcataag gctgctgata ttttggttag agatgccgaa      240

aaaattggtg ccgtcttgtc taaagaagtt gctaaaggtc acaaagctgc cgtttctgaa      300

gttattagaa ccgccgaaat tatcaactat gctgctgaag agggtttgag aatggaaggt      360

gaagttttgg aaggtggttc ttttgaagct gcttccaaaa aaaagatcgc catcgttaga      420

agagaaccag ttggtttggt tttggctatt tctccattca actacccagt taatttggcc      480

ggttcaaaaa ttgctccagc attgattgct ggtaacgttg ttgctttgaa accaccaact      540

caaggttcta tttctggttt gttgttggct gaagcttttg ctgaagctgg tattccagct      600

ggtgttttca acactattac tggtagaggt tccgttatcg gtgattacat cgttgaacat      660

gaagccgtta acttcatcaa tttcactggt tctactccaa tcggtgaagg tattggtaaa      720

ttggctggta tgaggccaat catgttggaa ttaggtggta aagattccgc cattgtcttg      780

gaagatgctg atttggcttt ggctgctaag aatatcgttg ctggtgcttt tggttattct      840

ggtcaaagat gtactgctgt taagcgtgtt ttggtcatgg ataaggttgc agatcaattg      900

gctgctgaaa tcaagacttt ggtcgaaaaa ttgtctgtcg gtatgcctga agatgatgca      960

gatattactc cattgattga taccaaggct gccgattttg ttgaaggttt gattaaggat     1020

gctaccgata agggtgctac tgctttgact gcttttaata gagaaggcaa cttgatctcc     1080

ccagttttgt ttgatcatgt taccaccgat atgagattgg cttgggaaga accatttggt     1140

ccagttttgc caattattag agttactact gtcgaagagg ccatcaagat ttctaacgaa     1200

tctgaatacg gtctgcaagc ctctattttt actaccaatt ttccaaaggc tttcggtatc     1260

gctgaacaat tggaagttgg tactgttcac ttgaacaaca agactcaaag aggtacagat     1320

aacttcccat ttttgggtgc taaaaagtct ggtgctggtg ttcaaggtgt taagtattct     1380

attgaagcta tgaccaccgt taagtccgtt gttttcgata tccaatga                  1428


<210>  72
<211>  475
<212>  PRT
<213>  Streptococcus pyogenes

<400>  72

Met Ala Lys Gln Tyr Lys Asn Leu Val Asn Gly Glu Trp Lys Leu Ser 
1               5                   10                  15      


Glu Asn Glu Ile Thr Ile Tyr Ala Pro Ala Thr Gly Glu Glu Leu Gly 
            20                  25                  30          


Ser Val Pro Ala Met Thr Gln Ala Glu Val Asp Ala Val Tyr Ala Ser 
        35                  40                  45              


Ala Lys Lys Ala Leu Pro Ala Trp Arg Ala Leu Ser Tyr Val Glu Arg 
    50                  55                  60                  


Ala Ala Tyr Leu His Lys Ala Ala Asp Ile Leu Val Arg Asp Ala Glu 
65                  70                  75                  80  


Lys Ile Gly Ala Val Leu Ser Lys Glu Val Ala Lys Gly His Lys Ala 
                85                  90                  95      


Ala Val Ser Glu Val Ile Arg Thr Ala Glu Ile Ile Asn Tyr Ala Ala 
            100                 105                 110         


Glu Glu Gly Leu Arg Met Glu Gly Glu Val Leu Glu Gly Gly Ser Phe 
        115                 120                 125             


Glu Ala Ala Ser Lys Lys Lys Ile Ala Ile Val Arg Arg Glu Pro Val 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Val Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Ile Ala Gly Asn Val Val Ala Leu 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Leu Leu Ala Glu Ala 
            180                 185                 190         


Phe Ala Glu Ala Gly Ile Pro Ala Gly Val Phe Asn Thr Ile Thr Gly 
        195                 200                 205             


Arg Gly Ser Val Ile Gly Asp Tyr Ile Val Glu His Glu Ala Val Asn 
    210                 215                 220                 


Phe Ile Asn Phe Thr Gly Ser Thr Pro Ile Gly Glu Gly Ile Gly Lys 
225                 230                 235                 240 


Leu Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ser 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Ala Leu Ala Ala Lys Asn Ile 
            260                 265                 270         


Val Ala Gly Ala Phe Gly Tyr Ser Gly Gln Arg Cys Thr Ala Val Lys 
        275                 280                 285             


Arg Val Leu Val Met Asp Lys Val Ala Asp Gln Leu Ala Ala Glu Ile 
    290                 295                 300                 


Lys Thr Leu Val Glu Lys Leu Ser Val Gly Met Pro Glu Asp Asp Ala 
305                 310                 315                 320 


Asp Ile Thr Pro Leu Ile Asp Thr Lys Ala Ala Asp Phe Val Glu Gly 
                325                 330                 335     


Leu Ile Lys Asp Ala Thr Asp Lys Gly Ala Thr Ala Leu Thr Ala Phe 
            340                 345                 350         


Asn Arg Glu Gly Asn Leu Ile Ser Pro Val Leu Phe Asp His Val Thr 
        355                 360                 365             


Thr Asp Met Arg Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Ile Ile Arg Val Thr Thr Val Glu Glu Ala Ile Lys Ile Ser Asn Glu 
385                 390                 395                 400 


Ser Glu Tyr Gly Leu Gln Ala Ser Ile Phe Thr Thr Asn Phe Pro Lys 
                405                 410                 415     


Ala Phe Gly Ile Ala Glu Gln Leu Glu Val Gly Thr Val His Leu Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Thr Asp Asn Phe Pro Phe Leu Gly Ala Lys 
        435                 440                 445             


Lys Ser Gly Ala Gly Val Gln Gly Val Lys Tyr Ser Ile Glu Ala Met 
    450                 455                 460                 


Thr Thr Val Lys Ser Val Val Phe Asp Ile Gln 
465                 470                 475 


<210>  73
<211>  1428
<212>  DNA
<213>  Streptococcus ictaluri

<400>  73
atgaccaaag agtacaagaa cttggttaac ggtgaatgga agttgtccga taacaacatt       60

actatctacg aaccagctac tggtaaagct ttgggttctg ttccagctat gtctcaagaa      120

gaggttgatt acgtttacgc ttctgctaaa caagctttgc caaaatggcg tgctttgtct      180

tatgttgaaa gagctgctta cttgcataag gctgctgata ttttggttag agatgccgaa      240

aagattggtg ccatcttgtc taaagaagtt gctaagggtt ttaaggctgc cgtttctgaa      300

gttgttagaa ccgctgaaat tatcaactat gctgctgaag agggtttgag aatgcaaggt      360

gaagttttgg aaggtggttc ttttgaagct gcttccaaaa aaaagatcgc catcgttaga      420

agagaaccag ttggtttggt tttggctatt tctccattca actacccagt taatttggcc      480

ggttctaaaa ttgctccagc tttgattgct ggtaacgttg ttgctttgaa accaccaact      540

caaggttcta tttctggttt gttgttggct gaagcttttg ctgaagctgg tattccagct      600

ggtgttttca acactattac tggtagaggt tccgttatcg gtgattacat cgttgaacat      660

gaagccgtta acttcatcaa cttcactggt tctactgcta ttggtgaagg tattggtaaa      720

ttggctggta tgaggccaat catgttggaa ttaggtggta aagattccgc cattgtcttg      780

gaagatgctg atttggtttt agctgctaag aacatagttt ctggtgcttt tggttactct      840

ggtcaaagat gtactgccgt taagagaatc ttggttatgg attctgttgc tgatcaattg      900

gcctccgaaa tcaagatttt ggtcgaacaa ttgtccgttg gtatccctga agaagatgca      960

gatattactc cattgattga taccaaggcc gctgattttg ttgaaggttt gattgatgat     1020

gctaaggcta aaggtgcttt ggctttgact gaatgtaaga gagataacaa cttgatctcc     1080

ccagttttgt tcgatagagt tactaccgat atgagattgg cttgggaaga accatttggt     1140

ccagttttgc ctttgatcag agtttcctct gttgaagaag ccatcgaaat ttctaacgct     1200

tccgaatatg gtctgcaagc ttctattttt accaacaact ttccacaagc tttcgctatc     1260

gctgaacaat tggaagttgg tactgttcac ttgaacaaca agactcaaag aggtacagat     1320

aacttcccat ttttgggtgc taaaaaatct ggtgctggtg ttcaaggtgt taagtactct     1380

attgaagcta tgaccaactt gaagtccgtt gttttcgata tcaagtaa                  1428


<210>  74
<211>  475
<212>  PRT
<213>  Streptococcus ictaluri

<400>  74

Met Thr Lys Glu Tyr Lys Asn Leu Val Asn Gly Glu Trp Lys Leu Ser 
1               5                   10                  15      


Asp Asn Asn Ile Thr Ile Tyr Glu Pro Ala Thr Gly Lys Ala Leu Gly 
            20                  25                  30          


Ser Val Pro Ala Met Ser Gln Glu Glu Val Asp Tyr Val Tyr Ala Ser 
        35                  40                  45              


Ala Lys Gln Ala Leu Pro Lys Trp Arg Ala Leu Ser Tyr Val Glu Arg 
    50                  55                  60                  


Ala Ala Tyr Leu His Lys Ala Ala Asp Ile Leu Val Arg Asp Ala Glu 
65                  70                  75                  80  


Lys Ile Gly Ala Ile Leu Ser Lys Glu Val Ala Lys Gly Phe Lys Ala 
                85                  90                  95      


Ala Val Ser Glu Val Val Arg Thr Ala Glu Ile Ile Asn Tyr Ala Ala 
            100                 105                 110         


Glu Glu Gly Leu Arg Met Gln Gly Glu Val Leu Glu Gly Gly Ser Phe 
        115                 120                 125             


Glu Ala Ala Ser Lys Lys Lys Ile Ala Ile Val Arg Arg Glu Pro Val 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Val Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Ile Ala Gly Asn Val Val Ala Leu 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Leu Leu Ala Glu Ala 
            180                 185                 190         


Phe Ala Glu Ala Gly Ile Pro Ala Gly Val Phe Asn Thr Ile Thr Gly 
        195                 200                 205             


Arg Gly Ser Val Ile Gly Asp Tyr Ile Val Glu His Glu Ala Val Asn 
    210                 215                 220                 


Phe Ile Asn Phe Thr Gly Ser Thr Ala Ile Gly Glu Gly Ile Gly Lys 
225                 230                 235                 240 


Leu Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ser 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Val Leu Ala Ala Lys Asn Ile 
            260                 265                 270         


Val Ser Gly Ala Phe Gly Tyr Ser Gly Gln Arg Cys Thr Ala Val Lys 
        275                 280                 285             


Arg Ile Leu Val Met Asp Ser Val Ala Asp Gln Leu Ala Ser Glu Ile 
    290                 295                 300                 


Lys Ile Leu Val Glu Gln Leu Ser Val Gly Ile Pro Glu Glu Asp Ala 
305                 310                 315                 320 


Asp Ile Thr Pro Leu Ile Asp Thr Lys Ala Ala Asp Phe Val Glu Gly 
                325                 330                 335     


Leu Ile Asp Asp Ala Lys Ala Lys Gly Ala Leu Ala Leu Thr Glu Cys 
            340                 345                 350         


Lys Arg Asp Asn Asn Leu Ile Ser Pro Val Leu Phe Asp Arg Val Thr 
        355                 360                 365             


Thr Asp Met Arg Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Leu Ile Arg Val Ser Ser Val Glu Glu Ala Ile Glu Ile Ser Asn Ala 
385                 390                 395                 400 


Ser Glu Tyr Gly Leu Gln Ala Ser Ile Phe Thr Asn Asn Phe Pro Gln 
                405                 410                 415     


Ala Phe Ala Ile Ala Glu Gln Leu Glu Val Gly Thr Val His Leu Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Thr Asp Asn Phe Pro Phe Leu Gly Ala Lys 
        435                 440                 445             


Lys Ser Gly Ala Gly Val Gln Gly Val Lys Tyr Ser Ile Glu Ala Met 
    450                 455                 460                 


Thr Asn Leu Lys Ser Val Val Phe Asp Ile Lys 
465                 470                 475 


<210>  75
<211>  1461
<212>  DNA
<213>  Clostridium perfringens

<400>  75
atgttctcct gcatcaaggg taaagaaaga accttcagaa acttgatcaa cggtgaatgg       60

atcaactcct catccgataa gttcatcgat atctattctc cagttggtaa ctgcttggtt      120

ggtaaagttc cagctatgac tactgatgaa gttgatttgg ctatcaagtc cgctaaagaa      180

gctcaaaagg tttggagaaa tgttccagtt aacaagagag ccgagatctt gtacaaagct      240

gccgatattt tgatcgaaaa ggttgaagat atcgccgaga tcatgatgag agaaattggt      300

aaggataaga agtccgccga atccgaaatt ttgagatctg ctgattacat taagttcact      360

gctgataccg ctaagaactt gtctggtgaa tctattccag gtgattcatt tccaggtttc      420

aagaggaaca agatttcctt ggttactaga gaaccattgg gtgttgtttt ggcaatttct      480

ccattcaact acccaatcaa tttggccgct tctaaaattg ctccagcttt ggttgctggt      540

aattccgttg ttttgaaacc agctactcaa ggttcattgt gtggtctgta tttggctaag      600

gtttttgaac aagctggtgt tcctgctggt gttttgaata ctgttactgg tagaggttcc      660

gaaatcggtg attatatcgt tacccatcca gagatcgatt tcattaactt tactggttct      720

accgaagttg gcaccagaat ttctagaatt actaccatgg ttcccttgtt gatggaatta      780

ggtggtaaag atgctgctat cgttttggct gatgctgatt tggatttggc tgcttcaaat      840

atcgttgctg gtgcttattc ttactctggt caaagatgta ctgccgtcaa gagaattttg      900

gttgttaatg aagttgccga caagttggtg gaaaaggtca aagaaaaggt ccagaacttg      960

aagattggta acccattgga agaagatgtt gatatcgttc cattgatcga ttctaaggct     1020

gctgattttg tttgggaatt gattgatgat gccagagaaa aaggtgccca tttgttggtt     1080

ggtggtacaa gagaagaaaa catgatctac ccaactttgt tcgataacgt taccaccgat     1140

atgagattgg cttgggaaga accatttggt ccagttttgc caattatcag agttaaggac     1200

aaggatgaag ccattgaaat cgctaacaaa tctgaatacg gcctgcaatc ttctgttttc     1260

accgaaaaca ttaacgaagc tttctacgtt gccgatagat tggaagttgg tactgttcaa     1320

gtcaacaaca agactgaaag aggtcctgat cattttccat tcttgggtgt taaggcttct     1380

ggtattggta cacaaggtat cagatactcc atcgaatcta tgtctagacc aaaggctacc     1440

gttatcaact tggttagatg a                                               1461


<210>  76
<211>  486
<212>  PRT
<213>  Clostridium perfringens

<400>  76

Met Phe Ser Cys Ile Lys Gly Lys Glu Arg Thr Phe Arg Asn Leu Ile 
1               5                   10                  15      


Asn Gly Glu Trp Ile Asn Ser Ser Ser Asp Lys Phe Ile Asp Ile Tyr 
            20                  25                  30          


Ser Pro Val Gly Asn Cys Leu Val Gly Lys Val Pro Ala Met Thr Thr 
        35                  40                  45              


Asp Glu Val Asp Leu Ala Ile Lys Ser Ala Lys Glu Ala Gln Lys Val 
    50                  55                  60                  


Trp Arg Asn Val Pro Val Asn Lys Arg Ala Glu Ile Leu Tyr Lys Ala 
65                  70                  75                  80  


Ala Asp Ile Leu Ile Glu Lys Val Glu Asp Ile Ala Glu Ile Met Met 
                85                  90                  95      


Arg Glu Ile Gly Lys Asp Lys Lys Ser Ala Glu Ser Glu Ile Leu Arg 
            100                 105                 110         


Ser Ala Asp Tyr Ile Lys Phe Thr Ala Asp Thr Ala Lys Asn Leu Ser 
        115                 120                 125             


Gly Glu Ser Ile Pro Gly Asp Ser Phe Pro Gly Phe Lys Arg Asn Lys 
    130                 135                 140                 


Ile Ser Leu Val Thr Arg Glu Pro Leu Gly Val Val Leu Ala Ile Ser 
145                 150                 155                 160 


Pro Phe Asn Tyr Pro Ile Asn Leu Ala Ala Ser Lys Ile Ala Pro Ala 
                165                 170                 175     


Leu Val Ala Gly Asn Ser Val Val Leu Lys Pro Ala Thr Gln Gly Ser 
            180                 185                 190         


Leu Cys Gly Leu Tyr Leu Ala Lys Val Phe Glu Gln Ala Gly Val Pro 
        195                 200                 205             


Ala Gly Val Leu Asn Thr Val Thr Gly Arg Gly Ser Glu Ile Gly Asp 
    210                 215                 220                 


Tyr Ile Val Thr His Pro Glu Ile Asp Phe Ile Asn Phe Thr Gly Ser 
225                 230                 235                 240 


Thr Glu Val Gly Thr Arg Ile Ser Arg Ile Thr Thr Met Val Pro Leu 
                245                 250                 255     


Leu Met Glu Leu Gly Gly Lys Asp Ala Ala Ile Val Leu Ala Asp Ala 
            260                 265                 270         


Asp Leu Asp Leu Ala Ala Ser Asn Ile Val Ala Gly Ala Tyr Ser Tyr 
        275                 280                 285             


Ser Gly Gln Arg Cys Thr Ala Val Lys Arg Ile Leu Val Val Asn Glu 
    290                 295                 300                 


Val Ala Asp Lys Leu Val Glu Lys Val Lys Glu Lys Val Gln Asn Leu 
305                 310                 315                 320 


Lys Ile Gly Asn Pro Leu Glu Glu Asp Val Asp Ile Val Pro Leu Ile 
                325                 330                 335     


Asp Ser Lys Ala Ala Asp Phe Val Trp Glu Leu Ile Asp Asp Ala Arg 
            340                 345                 350         


Glu Lys Gly Ala His Leu Leu Val Gly Gly Thr Arg Glu Glu Asn Met 
        355                 360                 365             


Ile Tyr Pro Thr Leu Phe Asp Asn Val Thr Thr Asp Met Arg Leu Ala 
    370                 375                 380                 


Trp Glu Glu Pro Phe Gly Pro Val Leu Pro Ile Ile Arg Val Lys Asp 
385                 390                 395                 400 


Lys Asp Glu Ala Ile Glu Ile Ala Asn Lys Ser Glu Tyr Gly Leu Gln 
                405                 410                 415     


Ser Ser Val Phe Thr Glu Asn Ile Asn Glu Ala Phe Tyr Val Ala Asp 
            420                 425                 430         


Arg Leu Glu Val Gly Thr Val Gln Val Asn Asn Lys Thr Glu Arg Gly 
        435                 440                 445             


Pro Asp His Phe Pro Phe Leu Gly Val Lys Ala Ser Gly Ile Gly Thr 
    450                 455                 460                 


Gln Gly Ile Arg Tyr Ser Ile Glu Ser Met Ser Arg Pro Lys Ala Thr 
465                 470                 475                 480 


Val Ile Asn Leu Val Arg 
                485     


<210>  77
<211>  1461
<212>  DNA
<213>  Clostridium chromiireducens

<400>  77
atgttcaact gcatcaagtg cgagaacaac aacttcaaga acttgattaa cggtgaatgg       60

gttggtaaca aggataacaa ggttatcgaa atctactccc cattggacaa ttctttggtt      120

ggtactgttc cagctatgac ccaagaagat attgatcacg ttattcaagt tgccaaggac      180

ggtcaaagag aatggtctaa agttccaatg aacgaaagag ccgagatctt gtacaaagct      240

gctgatattt tggttgaaaa cgccaacgaa ttggtcgaca ttatgattag agaaatcggc      300

aaggaccgta agagttccaa atctgaaatt catagaaccg ccgacttcat tagattcact      360

gctgatactg ctaagaacat ggctggtgaa tctattccag gtgatacttt tccaggtttc      420

aagaggaaca agatttccgt tgttaacaga gaaccattgg gtgttgtttt ggctatttct      480

ccattcaact accccattaa cttgtccgct tctaaaattg ctccagccat tatcgttggt      540

aactccgttg ttttgaaacc agctactcaa ggttctttgt gtggtctgta tttggctaag      600

gttttccaag aggctggtgt tccaaatggt gttttgaaca ctattactgg taagggttcc      660

gaaattggtg attatgctgt tactcataag ggcgtcaact tcattaactt tactggttct      720

actgaggtcg gtgtcaagat ttctaagatt acttctatgg tccccttgtt gatggaatta      780

ggtggtaaag atgctgccat cgttttgaaa gatgccgatt tggatttggc tgctaacaat      840

atcgttgctg gtggttattc ttactctggt caaagatgta ctgccgtcaa gagaattttg      900

gttttggaaa aggttgccga tgagttggtc aaaaaggtca aagaaaagat gtccaacttg      960

actgttggta acccattgga taaggatgtt gatatcgttc cattgatctc taccaagtct     1020

gctgatttcg ttgaagagtt gattaaggat gccattgata agggtgcaga tttggttgtt     1080

ggtggtaaaa gagatggtaa cttgatctac ccaaccttgt tcgataatgt taccggtgat     1140

atgagaattg cttgggaaga accatttggt ccagttttgc caattatgag agttaaggac     1200

aaggatgaag ccatcgaaat tgctaacaag tccgaatatg gtttacaagg tgctgttttc     1260

accgaaaaca ttgaagatgc tttctacgtt gccgatagat tggaagttgg tacagttcaa     1320

gttaacaaca agactgaaag aggtccagat cattttccat tcttgggtgt taaggcttct     1380

ggtattggta cacaaggtat cagatactcc atcgaatcta tgtctagacc aaaggctacc     1440

gttatcaact tggttagatg a                                               1461


<210>  78
<211>  486
<212>  PRT
<213>  Clostridium chromiireducens

<400>  78

Met Phe Asn Cys Ile Lys Cys Glu Asn Asn Asn Phe Lys Asn Leu Ile 
1               5                   10                  15      


Asn Gly Glu Trp Val Gly Asn Lys Asp Asn Lys Val Ile Glu Ile Tyr 
            20                  25                  30          


Ser Pro Leu Asp Asn Ser Leu Val Gly Thr Val Pro Ala Met Thr Gln 
        35                  40                  45              


Glu Asp Ile Asp His Val Ile Gln Val Ala Lys Asp Gly Gln Arg Glu 
    50                  55                  60                  


Trp Ser Lys Val Pro Met Asn Glu Arg Ala Glu Ile Leu Tyr Lys Ala 
65                  70                  75                  80  


Ala Asp Ile Leu Val Glu Asn Ala Asn Glu Leu Val Asp Ile Met Ile 
                85                  90                  95      


Arg Glu Ile Gly Lys Asp Arg Lys Ser Ser Lys Ser Glu Ile His Arg 
            100                 105                 110         


Thr Ala Asp Phe Ile Arg Phe Thr Ala Asp Thr Ala Lys Asn Met Ala 
        115                 120                 125             


Gly Glu Ser Ile Pro Gly Asp Thr Phe Pro Gly Phe Lys Arg Asn Lys 
    130                 135                 140                 


Ile Ser Val Val Asn Arg Glu Pro Leu Gly Val Val Leu Ala Ile Ser 
145                 150                 155                 160 


Pro Phe Asn Tyr Pro Ile Asn Leu Ser Ala Ser Lys Ile Ala Pro Ala 
                165                 170                 175     


Ile Ile Val Gly Asn Ser Val Val Leu Lys Pro Ala Thr Gln Gly Ser 
            180                 185                 190         


Leu Cys Gly Leu Tyr Leu Ala Lys Val Phe Gln Glu Ala Gly Val Pro 
        195                 200                 205             


Asn Gly Val Leu Asn Thr Ile Thr Gly Lys Gly Ser Glu Ile Gly Asp 
    210                 215                 220                 


Tyr Ala Val Thr His Lys Gly Val Asn Phe Ile Asn Phe Thr Gly Ser 
225                 230                 235                 240 


Thr Glu Val Gly Val Lys Ile Ser Lys Ile Thr Ser Met Val Pro Leu 
                245                 250                 255     


Leu Met Glu Leu Gly Gly Lys Asp Ala Ala Ile Val Leu Lys Asp Ala 
            260                 265                 270         


Asp Leu Asp Leu Ala Ala Asn Asn Ile Val Ala Gly Gly Tyr Ser Tyr 
        275                 280                 285             


Ser Gly Gln Arg Cys Thr Ala Val Lys Arg Ile Leu Val Leu Glu Lys 
    290                 295                 300                 


Val Ala Asp Glu Leu Val Lys Lys Val Lys Glu Lys Met Ser Asn Leu 
305                 310                 315                 320 


Thr Val Gly Asn Pro Leu Asp Lys Asp Val Asp Ile Val Pro Leu Ile 
                325                 330                 335     


Ser Thr Lys Ser Ala Asp Phe Val Glu Glu Leu Ile Lys Asp Ala Ile 
            340                 345                 350         


Asp Lys Gly Ala Asp Leu Val Val Gly Gly Lys Arg Asp Gly Asn Leu 
        355                 360                 365             


Ile Tyr Pro Thr Leu Phe Asp Asn Val Thr Gly Asp Met Arg Ile Ala 
    370                 375                 380                 


Trp Glu Glu Pro Phe Gly Pro Val Leu Pro Ile Met Arg Val Lys Asp 
385                 390                 395                 400 


Lys Asp Glu Ala Ile Glu Ile Ala Asn Lys Ser Glu Tyr Gly Leu Gln 
                405                 410                 415     


Gly Ala Val Phe Thr Glu Asn Ile Glu Asp Ala Phe Tyr Val Ala Asp 
            420                 425                 430         


Arg Leu Glu Val Gly Thr Val Gln Val Asn Asn Lys Thr Glu Arg Gly 
        435                 440                 445             


Pro Asp His Phe Pro Phe Leu Gly Val Lys Ala Ser Gly Ile Gly Thr 
    450                 455                 460                 


Gln Gly Ile Arg Tyr Ser Ile Glu Ser Met Ser Arg Pro Lys Ala Thr 
465                 470                 475                 480 


Val Ile Asn Leu Val Arg 
                485     


<210>  79
<211>  1461
<212>  DNA
<213>  Clostridium botulinum

<400>  79
atgttcaacc acatcaagga cgaaaacaac accttcaaga acttgattaa cggtgagtgg       60

gtttcctcta gatctttcgt tgaaatcaag tcccctctgt ctaattcttt gttgggtaga      120

gttccagcta tgaccaaaga agaagttgat attgctgttc agaccgctaa agaagctcaa      180

aaaaagtgga acaagatcac cattaacgaa agggctgaga tcttgtacaa agcctctgat      240

attttgttgg agaacatcga cgaactgtcc gaattgatga tgatggaaat tgccaaggat      300

agaaagtcct gcagatctga agtttctaga acctccgatt tcattaagtt cactgctgat      360

actgccaaga atttgtccgg tgaatctatt ccaggtgatt ctttcccagg tttcaaaaac      420

aacaaggtgt ccattgtcaa aagggaacca ttgggtgttg tattggctat ttctccattc      480

aactacccca ttaacttgtc cgcttctaaa attgctccag gtttgatggc tggtaactct      540

gttgttttga agccagctac tcaaggttct ttgtgtggtc tatatttggc cagaattttt      600

gaaaaggctg gtgttccagc tggtgttttg aacactatta ctggtaaggg ttctgaaatc      660

ggtgattaca ttactaccca taagggcatt aacttcatca acttcactgg ttctactgaa      720

gttggtgcta gaatttctaa gatgacctct atggttcccc tgttgatgga attaggtggt      780

aaagatgctg ctatcgtttt ggaagatgct gatttggaat tgactgcctc taatatcgtt      840

gctggtggtt attcttattc cggtcaaaga tgtactgccg tcaagagaat tttggttgtt      900

gataaggttg ccgacaagct gttggaaaag atcaaagaaa agatgaagaa actgaccgtc      960

ggtaacccat tggaaaaaga tgttgatatc gtccccttga tttcttctaa ggctgctgat     1020

ttcgttatcg aattgattga agatgccaag tccaaaggtg cagatttgat agttggtggt     1080

aatagagaag gcaacttgat ctatccaacc ttgtttgata acgttaccac cgatatgaga     1140

ttggcttggg aagaaccatt tggtccagtt ttgccaatta tcagagttaa ggataaggac     1200

gaagccattg aaatcgctaa caaatccgaa tatggtctgc aatctgctgt tttcaccaag     1260

aacattaacg atgcttttta cgtcgccgat aagttggaag ttggtactgt tcaaatcaac     1320

aacaagactg aaagaggtcc agataacttt ccttttatgg gtgtaaaagc ttccggtatt     1380

ggtacacaag gtatcaagta ctccatcgaa tctatgtcta gaccaaaggc caccattatc     1440

aacttgtcca ttcataacta a                                               1461


<210>  80
<211>  486
<212>  PRT
<213>  Clostridium botulinum

<400>  80

Met Phe Asn His Ile Lys Asp Glu Asn Asn Thr Phe Lys Asn Leu Ile 
1               5                   10                  15      


Asn Gly Glu Trp Val Ser Ser Arg Ser Phe Val Glu Ile Lys Ser Pro 
            20                  25                  30          


Leu Ser Asn Ser Leu Leu Gly Arg Val Pro Ala Met Thr Lys Glu Glu 
        35                  40                  45              


Val Asp Ile Ala Val Gln Thr Ala Lys Glu Ala Gln Lys Lys Trp Asn 
    50                  55                  60                  


Lys Ile Thr Ile Asn Glu Arg Ala Glu Ile Leu Tyr Lys Ala Ser Asp 
65                  70                  75                  80  


Ile Leu Leu Glu Asn Ile Asp Glu Leu Ser Glu Leu Met Met Met Glu 
                85                  90                  95      


Ile Ala Lys Asp Arg Lys Ser Cys Arg Ser Glu Val Ser Arg Thr Ser 
            100                 105                 110         


Asp Phe Ile Lys Phe Thr Ala Asp Thr Ala Lys Asn Leu Ser Gly Glu 
        115                 120                 125             


Ser Ile Pro Gly Asp Ser Phe Pro Gly Phe Lys Asn Asn Lys Val Ser 
    130                 135                 140                 


Ile Val Lys Arg Glu Pro Leu Gly Val Val Leu Ala Ile Ser Pro Phe 
145                 150                 155                 160 


Asn Tyr Pro Ile Asn Leu Ser Ala Ser Lys Ile Ala Pro Gly Leu Met 
                165                 170                 175     


Ala Gly Asn Ser Val Val Leu Lys Pro Ala Thr Gln Gly Ser Leu Cys 
            180                 185                 190         


Gly Leu Tyr Leu Ala Arg Ile Phe Glu Lys Ala Gly Val Pro Ala Gly 
        195                 200                 205             


Val Leu Asn Thr Ile Thr Gly Lys Gly Ser Glu Ile Gly Asp Tyr Ile 
    210                 215                 220                 


Thr Thr His Lys Gly Ile Asn Phe Ile Asn Phe Thr Gly Ser Thr Glu 
225                 230                 235                 240 


Val Gly Ala Arg Ile Ser Lys Met Thr Ser Met Val Pro Leu Leu Met 
                245                 250                 255     


Glu Leu Gly Gly Lys Asp Ala Ala Ile Val Leu Glu Asp Ala Asp Leu 
            260                 265                 270         


Glu Leu Thr Ala Ser Asn Ile Val Ala Gly Gly Tyr Ser Tyr Ser Gly 
        275                 280                 285             


Gln Arg Cys Thr Ala Val Lys Arg Ile Leu Val Val Asp Lys Val Ala 
    290                 295                 300                 


Asp Lys Leu Leu Glu Lys Ile Lys Glu Lys Met Lys Lys Leu Thr Val 
305                 310                 315                 320 


Gly Asn Pro Leu Glu Lys Asp Val Asp Ile Val Pro Leu Ile Ser Ser 
                325                 330                 335     


Lys Ala Ala Asp Phe Val Ile Glu Leu Ile Glu Asp Ala Lys Ser Lys 
            340                 345                 350         


Gly Ala Asp Leu Ile Val Gly Gly Asn Arg Glu Gly Asn Leu Ile Tyr 
        355                 360                 365             


Pro Thr Leu Phe Asp Asn Val Thr Thr Asp Met Arg Leu Ala Trp Glu 
    370                 375                 380                 


Glu Pro Phe Gly Pro Val Leu Pro Ile Ile Arg Val Lys Asp Lys Asp 
385                 390                 395                 400 


Glu Ala Ile Glu Ile Ala Asn Lys Ser Glu Tyr Gly Leu Gln Ser Ala 
                405                 410                 415     


Val Phe Thr Lys Asn Ile Asn Asp Ala Phe Tyr Val Ala Asp Lys Leu 
            420                 425                 430         


Glu Val Gly Thr Val Gln Ile Asn Asn Lys Thr Glu Arg Gly Pro Asp 
        435                 440                 445             


Asn Phe Pro Phe Met Gly Val Lys Ala Ser Gly Ile Gly Thr Gln Gly 
    450                 455                 460                 


Ile Lys Tyr Ser Ile Glu Ser Met Ser Arg Pro Lys Ala Thr Ile Ile 
465                 470                 475                 480 


Asn Leu Ser Ile His Asn 
                485     


<210>  81
<211>  1440
<212>  DNA
<213>  Bacillus cereus

<400>  81
atgactacct ctaacaccta caagttctac ttgaatggtg aatggcgtga atcttcttct       60

ggtgaaacta ttgaaatccc ctctccatac ttgcatgaag ttattggtca agttcaagcc      120

attaccagag gtgaagttga tgaagctatt gcttctgcta aagaagctca aaaatcttgg      180

gcagaagctt ccttgcaaga tagagctaaa tacttgtaca aatgggccga tgaattggtc      240

aatatgcaag acgaaattgc cgacatcatc atgaaggaag ttggtaaagg ttacaaggac      300

gccaagaaag aagttgttag aaccgctgat ttcatcaggt acactattga agaggcttta      360

cacatgcatg gtgaatctat gatgggtgat tcttttccag gtggtactaa gtctaagttg      420

gccattattc aaagggctcc attgggtgtt gttttggcta ttgctccatt caattaccca      480

gttaatttgt ccgctgctaa attggctcca gctttgatta tgggtaacgc cgttattttc      540

aaaccagcta ctcaaggtgc tatctccggt attaagatgg ttgaagcctt gcataaggct      600

ggtttgccaa aaggtttggt taatgttgct actggtagag gttctgttat cggtgattat      660

ttggttgaac acgagggtat caacatggtt tctttcactg gtggtacaaa caccggtaaa      720

catttggcta aaaaggctgc tatgatccca ttggttttgg aattaggtgg taaagatcca      780

ggtatcgtta gagaagatgc tgacttacaa gatgctgcta accatatagt ttctggtgct      840

ttttcttact ccggtcaaag atgtactgct atcaaaagag ttttggtcca cgaaaacgtt      900

gctgacgaat tggttggttt gttgcaagaa caagttgcca aattgtctgt tggttctcct      960

gaacaagatt ctactatcgt tccattgatc gatgataagt ctgccgattt tgttcaaggc     1020

ttggttgatg atgctgttga aaaaggtgct accatcgtta ttggtaacaa gagggaaaga     1080

aacttgatct acccaacctt gattgatcac gttaccgaag atatgaaggt tgcttgggaa     1140

gaaccatttg gtccaatttt gccaattatc agagtctcct ctgatgaaca agccattgaa     1200

attgctaaca agtctgaatt cggtctgcaa gcttctgttt tcaccaagga tattaacaag     1260

gctttcgcta ttgccaacaa gattgaaact ggttccgttc aaatcaacgg tagaactgaa     1320

agaggtccag atcattttcc tttcattggt gtaaaaggtt ctggtatggg tgctcaaggt     1380

attagaaaat ccttggaatc catgaccaga gaaaaggtta ctgttttgaa cctggtctaa     1440


<210>  82
<211>  479
<212>  PRT
<213>  Bacillus cereus

<400>  82

Met Thr Thr Ser Asn Thr Tyr Lys Phe Tyr Leu Asn Gly Glu Trp Arg 
1               5                   10                  15      


Glu Ser Ser Ser Gly Glu Thr Ile Glu Ile Pro Ser Pro Tyr Leu His 
            20                  25                  30          


Glu Val Ile Gly Gln Val Gln Ala Ile Thr Arg Gly Glu Val Asp Glu 
        35                  40                  45              


Ala Ile Ala Ser Ala Lys Glu Ala Gln Lys Ser Trp Ala Glu Ala Ser 
    50                  55                  60                  


Leu Gln Asp Arg Ala Lys Tyr Leu Tyr Lys Trp Ala Asp Glu Leu Val 
65                  70                  75                  80  


Asn Met Gln Asp Glu Ile Ala Asp Ile Ile Met Lys Glu Val Gly Lys 
                85                  90                  95      


Gly Tyr Lys Asp Ala Lys Lys Glu Val Val Arg Thr Ala Asp Phe Ile 
            100                 105                 110         


Arg Tyr Thr Ile Glu Glu Ala Leu His Met His Gly Glu Ser Met Met 
        115                 120                 125             


Gly Asp Ser Phe Pro Gly Gly Thr Lys Ser Lys Leu Ala Ile Ile Gln 
    130                 135                 140                 


Arg Ala Pro Leu Gly Val Val Leu Ala Ile Ala Pro Phe Asn Tyr Pro 
145                 150                 155                 160 


Val Asn Leu Ser Ala Ala Lys Leu Ala Pro Ala Leu Ile Met Gly Asn 
                165                 170                 175     


Ala Val Ile Phe Lys Pro Ala Thr Gln Gly Ala Ile Ser Gly Ile Lys 
            180                 185                 190         


Met Val Glu Ala Leu His Lys Ala Gly Leu Pro Lys Gly Leu Val Asn 
        195                 200                 205             


Val Ala Thr Gly Arg Gly Ser Val Ile Gly Asp Tyr Leu Val Glu His 
    210                 215                 220                 


Glu Gly Ile Asn Met Val Ser Phe Thr Gly Gly Thr Asn Thr Gly Lys 
225                 230                 235                 240 


His Leu Ala Lys Lys Ala Ala Met Ile Pro Leu Val Leu Glu Leu Gly 
                245                 250                 255     


Gly Lys Asp Pro Gly Ile Val Arg Glu Asp Ala Asp Leu Gln Asp Ala 
            260                 265                 270         


Ala Asn His Ile Val Ser Gly Ala Phe Ser Tyr Ser Gly Gln Arg Cys 
        275                 280                 285             


Thr Ala Ile Lys Arg Val Leu Val His Glu Asn Val Ala Asp Glu Leu 
    290                 295                 300                 


Val Gly Leu Leu Gln Glu Gln Val Ala Lys Leu Ser Val Gly Ser Pro 
305                 310                 315                 320 


Glu Gln Asp Ser Thr Ile Val Pro Leu Ile Asp Asp Lys Ser Ala Asp 
                325                 330                 335     


Phe Val Gln Gly Leu Val Asp Asp Ala Val Glu Lys Gly Ala Thr Ile 
            340                 345                 350         


Val Ile Gly Asn Lys Arg Glu Arg Asn Leu Ile Tyr Pro Thr Leu Ile 
        355                 360                 365             


Asp His Val Thr Glu Asp Met Lys Val Ala Trp Glu Glu Pro Phe Gly 
    370                 375                 380                 


Pro Ile Leu Pro Ile Ile Arg Val Ser Ser Asp Glu Gln Ala Ile Glu 
385                 390                 395                 400 


Ile Ala Asn Lys Ser Glu Phe Gly Leu Gln Ala Ser Val Phe Thr Lys 
                405                 410                 415     


Asp Ile Asn Lys Ala Phe Ala Ile Ala Asn Lys Ile Glu Thr Gly Ser 
            420                 425                 430         


Val Gln Ile Asn Gly Arg Thr Glu Arg Gly Pro Asp His Phe Pro Phe 
        435                 440                 445             


Ile Gly Val Lys Gly Ser Gly Met Gly Ala Gln Gly Ile Arg Lys Ser 
    450                 455                 460                 


Leu Glu Ser Met Thr Arg Glu Lys Val Thr Val Leu Asn Leu Val 
465                 470                 475                 


<210>  83
<211>  1440
<212>  DNA
<213>  Bacillus anthracis

<400>  83
atgactacct ctaacaccta caagttctac ttgaatggtg aatggcgtga atcttcttct       60

ggtgaaacta ttgaaatccc ctctccatac ttgcatgaag ttattggtca agttcaagcc      120

attaccagag gtgaagttga tgaagctatt gcttctgcta aagaagctca aaaatcttgg      180

gcagaagctt ccttgcaaga tagagctaaa tacttgtaca aatgggccga tgaattggtc      240

aatatgcaag acgaaattgc cgacatcatc atgaaggaag ttggtaaagg ttacaaggac      300

gccaagaaag aagttgttag aaccgctgat ttcatcaggt acactattga agaggcttta      360

cacatgcatg gtgaatctat gatgggtgat tcttttccag gtggtactaa gtctaagttg      420

gccattattc aaagggctcc attgggtgtt gttttggcta ttgctccatt caattaccca      480

gttaatttgt ccgctgctaa attggctcca gctttgatta tgggtaacgc cgttattttc      540

aaaccagcta ctcaaggtgc tatctccggt attaagatgg ttgaagcctt gcataaggct      600

ggtttgccaa aaggtttggt taatgttgct actggtagag gttctgttat cggtgattat      660

ttggttgaac acgagggtat caacatggtt tctttcactg gtggtacaaa caccggtaaa      720

catttggcta aaaaggctgc tatgatccca ttggttttgg aattaggtgg taaagatcca      780

ggtatcgtta gagaagatgc tgacttacaa gatgctgcta accatatagt ttctggtgct      840

ttttcttact ccggtcaaag atgtactgct atcaaaagag ttttggtcca cgaaaacgtt      900

gctgacgaat tggttggttt gttgaaagaa caagttgcca agttgtctgt tggttctcct      960

gaacaagatt ctactatcgt tccattgatc gatgataagt ctgccgattt tgttcaaggc     1020

ttggttgatg atgctgttga aaaaggtgct accatcgtta ttggtaacaa cagggaaaga     1080

aacttgatct acccaacctt gattgatcac gttaccgaag aaatgaaggt tgcttgggaa     1140

gaaccatttg gtccaatttt gccaattatc agagtctcct ctgatgaaca agccattgaa     1200

attgctaaca agtctgaatt cggtctgcaa gcttctgttt tcaccaagga tattaacaag     1260

gctttcgcta ttgccaacaa gattgaaact ggttccgttc aaatcaacgg tagaactgaa     1320

agaggtccag atcattttcc tttcattggt gtaaaaggtt ctggtatggg tgctcaaggt     1380

attagaaaat ccttggaatc catgaccaga gaaaaggtta ctgttttgaa cctggtctaa     1440


<210>  84
<211>  479
<212>  PRT
<213>  Bacillus anthracis

<400>  84

Met Thr Thr Ser Asn Thr Tyr Lys Phe Tyr Leu Asn Gly Glu Trp Arg 
1               5                   10                  15      


Glu Ser Ser Ser Gly Glu Thr Ile Glu Ile Pro Ser Pro Tyr Leu His 
            20                  25                  30          


Glu Val Ile Gly Gln Val Gln Ala Ile Thr Arg Gly Glu Val Asp Glu 
        35                  40                  45              


Ala Ile Ala Ser Ala Lys Glu Ala Gln Lys Ser Trp Ala Glu Ala Ser 
    50                  55                  60                  


Leu Gln Asp Arg Ala Lys Tyr Leu Tyr Lys Trp Ala Asp Glu Leu Val 
65                  70                  75                  80  


Asn Met Gln Asp Glu Ile Ala Asp Ile Ile Met Lys Glu Val Gly Lys 
                85                  90                  95      


Gly Tyr Lys Asp Ala Lys Lys Glu Val Val Arg Thr Ala Asp Phe Ile 
            100                 105                 110         


Arg Tyr Thr Ile Glu Glu Ala Leu His Met His Gly Glu Ser Met Met 
        115                 120                 125             


Gly Asp Ser Phe Pro Gly Gly Thr Lys Ser Lys Leu Ala Ile Ile Gln 
    130                 135                 140                 


Arg Ala Pro Leu Gly Val Val Leu Ala Ile Ala Pro Phe Asn Tyr Pro 
145                 150                 155                 160 


Val Asn Leu Ser Ala Ala Lys Leu Ala Pro Ala Leu Ile Met Gly Asn 
                165                 170                 175     


Ala Val Ile Phe Lys Pro Ala Thr Gln Gly Ala Ile Ser Gly Ile Lys 
            180                 185                 190         


Met Val Glu Ala Leu His Lys Ala Gly Leu Pro Lys Gly Leu Val Asn 
        195                 200                 205             


Val Ala Thr Gly Arg Gly Ser Val Ile Gly Asp Tyr Leu Val Glu His 
    210                 215                 220                 


Glu Gly Ile Asn Met Val Ser Phe Thr Gly Gly Thr Asn Thr Gly Lys 
225                 230                 235                 240 


His Leu Ala Lys Lys Ala Ala Met Ile Pro Leu Val Leu Glu Leu Gly 
                245                 250                 255     


Gly Lys Asp Pro Gly Ile Val Arg Glu Asp Ala Asp Leu Gln Asp Ala 
            260                 265                 270         


Ala Asn His Ile Val Ser Gly Ala Phe Ser Tyr Ser Gly Gln Arg Cys 
        275                 280                 285             


Thr Ala Ile Lys Arg Val Leu Val His Glu Asn Val Ala Asp Glu Leu 
    290                 295                 300                 


Val Gly Leu Leu Lys Glu Gln Val Ala Lys Leu Ser Val Gly Ser Pro 
305                 310                 315                 320 


Glu Gln Asp Ser Thr Ile Val Pro Leu Ile Asp Asp Lys Ser Ala Asp 
                325                 330                 335     


Phe Val Gln Gly Leu Val Asp Asp Ala Val Glu Lys Gly Ala Thr Ile 
            340                 345                 350         


Val Ile Gly Asn Asn Arg Glu Arg Asn Leu Ile Tyr Pro Thr Leu Ile 
        355                 360                 365             


Asp His Val Thr Glu Glu Met Lys Val Ala Trp Glu Glu Pro Phe Gly 
    370                 375                 380                 


Pro Ile Leu Pro Ile Ile Arg Val Ser Ser Asp Glu Gln Ala Ile Glu 
385                 390                 395                 400 


Ile Ala Asn Lys Ser Glu Phe Gly Leu Gln Ala Ser Val Phe Thr Lys 
                405                 410                 415     


Asp Ile Asn Lys Ala Phe Ala Ile Ala Asn Lys Ile Glu Thr Gly Ser 
            420                 425                 430         


Val Gln Ile Asn Gly Arg Thr Glu Arg Gly Pro Asp His Phe Pro Phe 
        435                 440                 445             


Ile Gly Val Lys Gly Ser Gly Met Gly Ala Gln Gly Ile Arg Lys Ser 
    450                 455                 460                 


Leu Glu Ser Met Thr Arg Glu Lys Val Thr Val Leu Asn Leu Val 
465                 470                 475                 


<210>  85
<211>  1440
<212>  DNA
<213>  Bacillus thuringiensis

<400>  85
atgactacct ctaacaccta caagttctac ttgaatggtg aatggcgtga atcttcttct       60

ggtgaaacta ttgaaatccc ctctccatac ttgcatgaag ttattggtca agttcaagcc      120

attaccagag gtgaagttga tgaagctatt gcttctgcta aagaagctca aaaatcttgg      180

gcagaagctt ccttgcaaga tagagctaaa tacttgtaca aatgggccga tgaattggtc      240

aatatgcaag acgaaattgc caacatcatc atgaaggaag ttggtaaggg ttacaaggat      300

gccaagaaag aagttgttag aaccgccgat ttcatcagat acactattga agaggcttta      360

cacatgcacg gtgaatctat gatgggtgat tcttttccag gtggtactaa gtctaagttg      420

gccattattc aaagggctcc attgggtgtt gttttggcta ttgctccatt caattaccca      480

gttaatttgt ccgctgctaa attggctcca gctttgatta tgggtaacgc cgttattttc      540

aaaccagcta ctcaaggtgc tatctccggt attaagatgg ttgaagcctt gcataaggct      600

ggtttgccaa aaggtttggt taatgttgct actggtagag gttctgttat cggtgattat      660

ttggttgaac acgagggtat caacatggtt tctttcactg gtggtacaaa caccggtaaa      720

catttggcta aaaaggctgc tatgatccca ttggttttgg aattaggtgg taaagatcca      780

ggtatcgtta gagaagatgc tgacttacaa gatgctgcta accatatagt ttctggtgct      840

ttttcttact ccggtcaaag atgtactgct atcaaaagag ttttggtcca cgaaaacgtt      900

gctgacgaat tggttggttt gttgaaagaa caagttgcca agttgtctgt tggttctcct      960

gaacaagatt ctactatcgt tccattgatc gatgataagt ccgctgattt tgttcaaggc     1020

ttggttgatg atgctgttga aaaaggtgct accatcgtta ttggtaacaa gagggaaaga     1080

aacttgatct acccaacctt gattgatcac gttaccgaag aaatgaaggt tgcttgggaa     1140

gaaccatttg gtccaatttt gccaattatc agagtctcct ctgatgaaca agccattgaa     1200

attgctaaca agtctgaatt cggtctgcaa gcttctgttt tcaccaagga tattaacaag     1260

gctttcgcta tcgccaacaa gattgaaact ggttctgttc aaatcaacgg tagaactgaa     1320

agaggtccag atcattttcc tttcattggt gtaaaaggtt ctggtatggg tgctcaaggt     1380

attagaaaat ccttggaatc catgaccaga gaaaaggtta ctgttttgaa cctggtctaa     1440


<210>  86
<211>  479
<212>  PRT
<213>  Bacillus thuringiensis

<400>  86

Met Thr Thr Ser Asn Thr Tyr Lys Phe Tyr Leu Asn Gly Glu Trp Arg 
1               5                   10                  15      


Glu Ser Ser Ser Gly Glu Thr Ile Glu Ile Pro Ser Pro Tyr Leu His 
            20                  25                  30          


Glu Val Ile Gly Gln Val Gln Ala Ile Thr Arg Gly Glu Val Asp Glu 
        35                  40                  45              


Ala Ile Ala Ser Ala Lys Glu Ala Gln Lys Ser Trp Ala Glu Ala Ser 
    50                  55                  60                  


Leu Gln Asp Arg Ala Lys Tyr Leu Tyr Lys Trp Ala Asp Glu Leu Val 
65                  70                  75                  80  


Asn Met Gln Asp Glu Ile Ala Asn Ile Ile Met Lys Glu Val Gly Lys 
                85                  90                  95      


Gly Tyr Lys Asp Ala Lys Lys Glu Val Val Arg Thr Ala Asp Phe Ile 
            100                 105                 110         


Arg Tyr Thr Ile Glu Glu Ala Leu His Met His Gly Glu Ser Met Met 
        115                 120                 125             


Gly Asp Ser Phe Pro Gly Gly Thr Lys Ser Lys Leu Ala Ile Ile Gln 
    130                 135                 140                 


Arg Ala Pro Leu Gly Val Val Leu Ala Ile Ala Pro Phe Asn Tyr Pro 
145                 150                 155                 160 


Val Asn Leu Ser Ala Ala Lys Leu Ala Pro Ala Leu Ile Met Gly Asn 
                165                 170                 175     


Ala Val Ile Phe Lys Pro Ala Thr Gln Gly Ala Ile Ser Gly Ile Lys 
            180                 185                 190         


Met Val Glu Ala Leu His Lys Ala Gly Leu Pro Lys Gly Leu Val Asn 
        195                 200                 205             


Val Ala Thr Gly Arg Gly Ser Val Ile Gly Asp Tyr Leu Val Glu His 
    210                 215                 220                 


Glu Gly Ile Asn Met Val Ser Phe Thr Gly Gly Thr Asn Thr Gly Lys 
225                 230                 235                 240 


His Leu Ala Lys Lys Ala Ala Met Ile Pro Leu Val Leu Glu Leu Gly 
                245                 250                 255     


Gly Lys Asp Pro Gly Ile Val Arg Glu Asp Ala Asp Leu Gln Asp Ala 
            260                 265                 270         


Ala Asn His Ile Val Ser Gly Ala Phe Ser Tyr Ser Gly Gln Arg Cys 
        275                 280                 285             


Thr Ala Ile Lys Arg Val Leu Val His Glu Asn Val Ala Asp Glu Leu 
    290                 295                 300                 


Val Gly Leu Leu Lys Glu Gln Val Ala Lys Leu Ser Val Gly Ser Pro 
305                 310                 315                 320 


Glu Gln Asp Ser Thr Ile Val Pro Leu Ile Asp Asp Lys Ser Ala Asp 
                325                 330                 335     


Phe Val Gln Gly Leu Val Asp Asp Ala Val Glu Lys Gly Ala Thr Ile 
            340                 345                 350         


Val Ile Gly Asn Lys Arg Glu Arg Asn Leu Ile Tyr Pro Thr Leu Ile 
        355                 360                 365             


Asp His Val Thr Glu Glu Met Lys Val Ala Trp Glu Glu Pro Phe Gly 
    370                 375                 380                 


Pro Ile Leu Pro Ile Ile Arg Val Ser Ser Asp Glu Gln Ala Ile Glu 
385                 390                 395                 400 


Ile Ala Asn Lys Ser Glu Phe Gly Leu Gln Ala Ser Val Phe Thr Lys 
                405                 410                 415     


Asp Ile Asn Lys Ala Phe Ala Ile Ala Asn Lys Ile Glu Thr Gly Ser 
            420                 425                 430         


Val Gln Ile Asn Gly Arg Thr Glu Arg Gly Pro Asp His Phe Pro Phe 
        435                 440                 445             


Ile Gly Val Lys Gly Ser Gly Met Gly Ala Gln Gly Ile Arg Lys Ser 
    450                 455                 460                 


Leu Glu Ser Met Thr Arg Glu Lys Val Thr Val Leu Asn Leu Val 
465                 470                 475                 


<210>  87
<211>  1005
<212>  DNA
<213>  Pyrococcus furiosus

<400>  87
atgaagatca aggttggtat caacggttac ggtactattg gtaaaagagt tgcttacgct       60

gttaccaagc aagatgatat ggaattgatc ggtgttacta agaccaagcc agattttgaa      120

gcttacagag ctaaagaatt gggtattcca gtttacgctg cttctgaaga atttttgcca      180

agatttgaaa aggccggttt cgaagttgaa ggtactttga atgatttgtt ggagaaggtt      240

gatatcatcg ttgatgctac tccaggtggt atgggtgaaa aaaacaagca gttgtacgaa      300

aaggctggtg ttaaggctat ttttcaaggt ggtgaaaaag ctgaagttgc ccaagtttct      360

tttgttgctc aagctaatta tgaagccgcc ttgggtaaag attacgttag agttgtttct      420

tgtaacacca ccggtttggt tagaacattg aacgctatta aggattacgt cgattacgtt      480

tacgccgtta tgattagaag ggctgctgat ccaaatgata ttaagagagg tcctattaac      540

gccatcaagc catctgttac tattccatct catcatggtc cagatgttca aaccgttatt      600

ccaatcaaca ttgaaacctc cgctttcgtt gttccaacta ccattatgca tgttcactcc      660

atcatggtgg aattgaaaaa gccattgacc agagaagatg ttatcgacat cttcgaaaac      720

accaccagag ttttgttgtt cgaaaaagaa aagggtttcg aatccaccgc tcaattgatt      780

gaatttgcta gagacttgca ccgtgaatgg aacaacttat acgaaattgc cgtctggaaa      840

gagtccatta acgtaaaggg taaccgtttg ttctacatcc aagctgttca tcaagaatcc      900

gatgttatcc cagaaaacat tgatgctatt agggccatgt tcgaaattgc tgaaaaatgg      960

gagtctatca aaaagaccaa caagtccttg ggtatcctga agtaa                     1005


<210>  88
<211>  334
<212>  PRT
<213>  Pyrococcus furiosus

<400>  88

Met Lys Ile Lys Val Gly Ile Asn Gly Tyr Gly Thr Ile Gly Lys Arg 
1               5                   10                  15      


Val Ala Tyr Ala Val Thr Lys Gln Asp Asp Met Glu Leu Ile Gly Val 
            20                  25                  30          


Thr Lys Thr Lys Pro Asp Phe Glu Ala Tyr Arg Ala Lys Glu Leu Gly 
        35                  40                  45              


Ile Pro Val Tyr Ala Ala Ser Glu Glu Phe Leu Pro Arg Phe Glu Lys 
    50                  55                  60                  


Ala Gly Phe Glu Val Glu Gly Thr Leu Asn Asp Leu Leu Glu Lys Val 
65                  70                  75                  80  


Asp Ile Ile Val Asp Ala Thr Pro Gly Gly Met Gly Glu Lys Asn Lys 
                85                  90                  95      


Gln Leu Tyr Glu Lys Ala Gly Val Lys Ala Ile Phe Gln Gly Gly Glu 
            100                 105                 110         


Lys Ala Glu Val Ala Gln Val Ser Phe Val Ala Gln Ala Asn Tyr Glu 
        115                 120                 125             


Ala Ala Leu Gly Lys Asp Tyr Val Arg Val Val Ser Cys Asn Thr Thr 
    130                 135                 140                 


Gly Leu Val Arg Thr Leu Asn Ala Ile Lys Asp Tyr Val Asp Tyr Val 
145                 150                 155                 160 


Tyr Ala Val Met Ile Arg Arg Ala Ala Asp Pro Asn Asp Ile Lys Arg 
                165                 170                 175     


Gly Pro Ile Asn Ala Ile Lys Pro Ser Val Thr Ile Pro Ser His His 
            180                 185                 190         


Gly Pro Asp Val Gln Thr Val Ile Pro Ile Asn Ile Glu Thr Ser Ala 
        195                 200                 205             


Phe Val Val Pro Thr Thr Ile Met His Val His Ser Ile Met Val Glu 
    210                 215                 220                 


Leu Lys Lys Pro Leu Thr Arg Glu Asp Val Ile Asp Ile Phe Glu Asn 
225                 230                 235                 240 


Thr Thr Arg Val Leu Leu Phe Glu Lys Glu Lys Gly Phe Glu Ser Thr 
                245                 250                 255     


Ala Gln Leu Ile Glu Phe Ala Arg Asp Leu His Arg Glu Trp Asn Asn 
            260                 265                 270         


Leu Tyr Glu Ile Ala Val Trp Lys Glu Ser Ile Asn Val Lys Gly Asn 
        275                 280                 285             


Arg Leu Phe Tyr Ile Gln Ala Val His Gln Glu Ser Asp Val Ile Pro 
    290                 295                 300                 


Glu Asn Ile Asp Ala Ile Arg Ala Met Phe Glu Ile Ala Glu Lys Trp 
305                 310                 315                 320 


Glu Ser Ile Lys Lys Thr Asn Lys Ser Leu Gly Ile Leu Lys 
                325                 330                 


