               SEQUENCE LISTING

<110> Københavns Universitet

<120> GLP-1 and Neurotensin receptor co-agonist

<130> 138437

<160> 70

<170> BiSSAP 1.3.6

<210> 1
<211> 9
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-15 aa)

<400> 1
His Ala Glu Gly Thr Phe Thr Ser Asp 
1               5                   

<210> 2
<211> 30
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-36)

<400> 2
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  

<210> 3
<211> 29
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-35)

<400> 3
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  

<210> 4
<211> 28
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-34)

<400> 4
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys 
            20                  25              

<210> 5
<211> 27
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-33)

<400> 5
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val 
            20                  25          

<210> 6
<211> 26
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-32)

<400> 6
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 
            20                  25      

<210> 7
<211> 25
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-31)

<400> 7
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp 
            20                  25  

<210> 8
<211> 24
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-30)

<400> 8
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala 
            20                  

<210> 9
<211> 23
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-29)

<400> 9
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile 
            20              

<210> 10
<211> 22
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-28)

<400> 10
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe 
            20          

<210> 11
<211> 21
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-27)

<400> 11
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu 
            20      

<210> 12
<211> 20
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-26)

<400> 12
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys 
            20  

<210> 13
<211> 19
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-25)

<400> 13
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala 
            

<210> 14
<211> 18
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-24)

<400> 14
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala 
        

<210> 15
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-23)

<400> 15
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln 
    

<210> 16
<211> 16
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-22)

<400> 16
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      



<210> 17
<211> 15
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-21)

<400> 17
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
1               5                   10                  15  

<210> 18
<211> 14
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-20)

<400> 18
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 
1               5                   10                  

<210> 19
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-19)

<400> 19
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 
1               5                   10              

<210> 20
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-18)

<400> 20
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 
1               5                   10          

<210> 21
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-17)

<400> 21
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 
1               5                   10      

<210> 22
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-16)

<400> 22
His Ala Glu Gly Thr Phe Thr Ser Asp Val 
1               5                   10  

<210> 23
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-14)

<400> 23
His Ala Glu Gly Thr Phe Thr Ser 
1               5               

<210> 24
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> Neurotensin (NT) (1-13)

<400> 24
Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10              

<210> 25
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<223> NT (2-13)

<400> 25
Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10          

<210> 26
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<223> NT (3-13)

<400> 26
Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10      

<210> 27
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> NT (4-13)

<400> 27
Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10  

<210> 28
<211> 9
<212> PRT
<213> Homo sapiens


<220> 
<223> NT (5-13)

<400> 28
Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   

<210> 29
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> NT (6-13)

<400> 29
Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5               

<210> 30
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<223> NT (7-13)

<400> 30
Pro Arg Arg Pro Tyr Ile Leu 
1               5           

<210> 31
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<223> NT (8-13)

<400> 31
Arg Arg Pro Tyr Ile Leu 
1               5       

<210> 32
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-36)/NT (1-13)

<400> 32
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gln Leu 
            20                  25                  30          
Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
        35                  40              

<210> 33
<211> 52
<212> PRT
<213> Artificial Sequence


<220> 
<223> Exendin 4/NT (1-13)

<400> 33
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser Gln Leu Tyr Glu Asn Lys Pro Arg Arg 
        35                  40                  45              
Pro Tyr Ile Leu 
    50          

<210> 34
<211> 39
<212> PRT
<213> Homo sapiens


<220> 
<223> Exendin 4

<400> 34
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser 
        35                  

<210> 35
<211> 34
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-2

<400> 35
His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      
Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          
Asp Arg 
        

<210> 36
<211> 29
<212> PRT
<213> Homo sapiens


<220> 
<223> Glucagon

<400> 36
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  

<210> 37
<211> 28
<212> PRT
<213> Homo sapiens


<220> 
<223> VIP

<400> 37
His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      
Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              

<210> 38
<211> 33
<212> PRT
<213> Homo sapiens


<220> 
<223> Secretin

<400> 38
His Ser Asp Gly Thr Phe Thr Ser Glu Leu Ser Arg Leu Arg Glu Gly 
1               5                   10                  15      
Ala Arg Leu Gln Arg Leu Leu Gln Gly Leu Val Gly Lys Arg Ser Glu 
            20                  25                  30          
Gln 
    

<210> 39
<211> 38
<212> PRT
<213> Homo sapiens


<220> 
<223> PACAP-38

<400> 39
His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      
Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          
Gln Arg Val Lys Asn Lys 
        35              

<210> 40
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> NKA

<400> 40
His Lys Thr Asp Ser Phe Val Gly Leu Met 
1               5                   10  

<210> 41
<211> 34
<212> PRT
<213> Homo sapiens


<220> 
<223> PYY

<400> 41
Ile Lys Pro Glu Ala Pro Arg Glu Asp Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      
Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Val Thr Arg Gln 
            20                  25                  30          
Arg Tyr 
        

<210> 42
<211> 37
<212> PRT
<213> Homo sapiens


<220> 
<223> Amylin

<400> 42
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      
Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          
Gly Ser Asn Thr Tyr 
        35          

<210> 43
<211> 44
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP(7-37)/NT(1-13)

<400> 43
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Gln 
            20                  25                  30          
Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
        35                  40                  

<210> 44
<211> 31
<212> PRT
<213> Homo sapiens


<220> 
<223> GLP-1 (7-37)

<400> 44
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      

<210> 45
<211> 42
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-36)/NT (2-13)

<400> 45
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Leu Tyr 
            20                  25                  30          
Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
        35                  40          

<210> 46
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-37)/NT(2-13)

<400> 46
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Leu 
            20                  25                  30          
Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
        35                  40              

<210> 47
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic sequence

<400> 47
Lys Lys Gly Gly 
1               

<210> 48
<211> 9
<212> PRT
<213> Homo sapiens


<220> 
<221> VARIANT
<222> 1
<223> L-histidine, D-histidine, desamino-histidine, 2-amino-histidine,
      β hydroxy-histidine, homohistidine, Nα-acetyl-histidine,
      α-fluoromethyl-histidine, α-methyl-histidine, 3-pyridylalanine,
      2-pyridylalanine or 4 pyridylalanine

<220> 
<221> VARIANT
<222> 2
<223> A, G, V, L, I, K, S, aminoisobutyric acid (Aib), (1-aminocyclopro
      pyl) carboxylic acid, (1 aminocyclobutyl) carboxylic acid, (1-ami
      nocyclopentyl) carboxylic acid, (1 aminocyclohexyl) carboxylic ac
      id, (1-aminocycloheptyl) carboxylic acid, or (1-aminocycloocty

<220> 
<221> VARIANT
<222> 3
<223> E, D or Q

<220> 
<221> VARIANT
<222> 4
<223> G or A

<220> 
<221> VARIANT
<222> 5
<223> T, V, S or I

<220> 
<221> VARIANT
<222> 6
<223> F or Y

<220> 
<221> VARIANT
<222> 7
<223> T or S

<220> 
<221> VARIANT
<222> 8
<223> S, V or D

<220> 
<221> VARIANT
<222> 9
<223> S, D, E or is not present

<400> 48
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   

<210> 49
<211> 6
<212> PRT
<213> Homo sapiens


<220> 
<221> VARIANT
<222> 1
<223> R or K

<220> 
<221> VARIANT
<222> 2
<223> R or K

<220> 
<221> VARIANT
<222> 4
<223> Y, S, C or T

<400> 49
Xaa Xaa Pro Xaa Ile Leu 
1               5       

<210> 50
<211> 7
<212> PRT
<213> Homo sapiens


<220> 
<221> VARIANT
<222> 2
<223> R or K

<220> 
<221> VARIANT
<222> 3
<223> R or K

<220> 
<221> VARIANT
<222> 5
<223> Y, S, C or T

<400> 50
Pro Xaa Xaa Pro Xaa Ile Leu 
1               5           

<210> 51
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<221> VARIANT
<222> 3
<223> R or K

<220> 
<221> VARIANT
<222> 4
<223> R or K

<220> 
<221> VARIANT
<222> 6
<223> Y, S, C or T

<400> 51
Lys Pro Xaa Xaa Pro Xaa Ile Leu 
1               5               

<210> 52
<211> 9
<212> PRT
<213> Homo sapiens


<220> 
<221> VARIANT
<222> 4
<223> R or K

<220> 
<221> VARIANT
<222> 5
<223> R or K

<220> 
<221> VARIANT
<222> 7
<223> Y, S, C or T

<400> 52
Asn Lys Pro Xaa Xaa Pro Xaa Ile Leu 
1               5                   

<210> 53
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<221> VARIANT
<222> 5
<223> R or K

<220> 
<221> VARIANT
<222> 6
<223> R or K

<220> 
<221> VARIANT
<222> 8
<223> Y, S, C or T

<400> 53
Glu Asn Lys Pro Xaa Xaa Pro Xaa Ile Leu 
1               5                   10  

<210> 54
<211> 11
<212> PRT
<213> Homo sapiens


<220> 
<221> VARIANT
<222> 6
<223> R or K

<220> 
<221> VARIANT
<222> 7
<223> R or K

<220> 
<221> VARIANT
<222> 9
<223> Y, S, C or T

<400> 54
Tyr Glu Asn Lys Pro Xaa Xaa Pro Xaa Ile Leu 
1               5                   10      

<210> 55
<211> 12
<212> PRT
<213> Homo sapiens


<220> 
<221> VARIANT
<222> 7
<223> R or K

<220> 
<221> VARIANT
<222> 8
<223> R or K

<220> 
<221> VARIANT
<222> 10
<223> Y, S, C or T

<400> 55
Leu Tyr Glu Asn Lys Pro Xaa Xaa Pro Xaa Ile Leu 
1               5                   10          

<210> 56
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<221> VARIANT
<222> 8
<223> R or K

<220> 
<221> VARIANT
<222> 9
<223> R or K

<220> 
<221> VARIANT
<222> 11
<223> Y, S, C or T

<400> 56
Gln Leu Tyr Glu Asn Lys Pro Xaa Xaa Pro Xaa Ile Leu 
1               5                   10              

<210> 57
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-15)/NT (1-6)

<400> 57
His Ala Glu Gly Thr Phe Thr Ser Asp Arg Arg Pro Tyr Ile Leu 
1               5                   10                  15  

<210> 58
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-15)/KKGG Linker/NT (1-6)

<400> 58
His Ala Glu Gly Thr Phe Thr Ser Asp Lys Lys Gly Gly Arg Arg Pro 
1               5                   10                  15      
Tyr Ile Leu 
            

<210> 59
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-19)/NT (1-10)

<400> 59
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Glu Asn Lys 
1               5                   10                  15      
Pro Arg Arg Pro Tyr Ile Leu 
            20              

<210> 60
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-19)/KKGG Linker/NT (1-10)

<400> 60
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Lys Lys Gly 
1               5                   10                  15      
Gly Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
            20                  25          

<210> 61
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-23)/NT (1-13)

<400> 61
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Glu Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
            20                  25                  30  

<210> 62
<211> 34
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-23)/KKGG Linker/NT (1-13)

<400> 62
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Lys Lys Gly Gly Glu Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr 
            20                  25                  30          
Ile Leu 
        

<210> 63
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-26)/NT (1-13)

<400> 63
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile 
            20                  25                  30          
Leu 
    

<210> 64
<211> 37
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-26)/KKGG Linker/NT (1-13)

<400> 64
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Lys Lys Gly Gly Glu Leu Tyr Glu Asn Lys Pro Arg 
            20                  25                  30          
Arg Pro Tyr Ile Leu 
        35          

<210> 65
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-35)/PEGylated NT (1-13)

<220> 
<221> MOD_RES
<222> 36
<223> PEGylation

<400> 65
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Glu Leu 
            20                  25                  30          
Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
        35                  40              

<210> 66
<211> 47
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-35)/KKGG linker/PEGylated NT (1-13)

<220> 
<221> MOD_RES
<222> 40
<223> PEGylation

<400> 66
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Lys Lys 
            20                  25                  30          
Gly Gly Glu Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
        35                  40                  45          

<210> 67
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-35)/NT (1-13)

<400> 67
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Glu Leu 
            20                  25                  30          
Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
        35                  40              

<210> 68
<211> 47
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLP-1 (7-35)/KKGG linker/NT (1-13)

<400> 68
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Lys Lys 
            20                  25                  30          
Gly Gly Glu Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
        35                  40                  45          

<210> 69
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> NT (1-13)

<400> 69
Glu Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10              

<210> 70
<211> 13
<212> PRT
<213> Homo sapiens


<220> 
<223> PEGylated NT (1-13)

<220> 
<221> MOD_RES
<222> 6
<223> PEGylation

<400> 70
Glu Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10              

