                         SEQUENCE LISTING

<110>  㶫ҩҵ޹˾
 
<120>  CD19弰Ӧ

<130>  PP0841CNP2

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Kozak ᣩ

<400>  1
gccgccacc                                                                9


<210>  2
<211>  51
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ǰУᣩ

<400>  2
atgggcgtca aggtcctgtt cgccctgatc tgcatcgccg tcgccgaggc c                51


<210>  3
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ǰ

<400>  3

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210>  4
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2/16F10 LCDR1

<400>  4

Ser Ser Val Ser Tyr 
1               5   


<210>  5
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2/16F10 LCDR2

<400>  5

Ala Thr Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2/16F10 LCDR3

<400>  6

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 HCDR1

<400>  7

Gly Tyr Thr Phe Thr Glu Tyr Thr 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 HCDR2

<400>  8

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  9
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 HCDR3

<400>  9

Ala Arg Gly Gly Gly Tyr Tyr Gly Tyr Gly Asp Tyr 
1               5                   10          


<210>  10
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 LFR1

<400>  10

Met Thr Cys Arg Ala Ser 
1               5       


<210>  11
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2/16F10 LFR2

<400>  11

Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  12
<211>  36
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2/16F10 LFR3

<400>  12

Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  13
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 LFR4

<400>  13

Phe Gly Ser Gly Thr Lys Leu Glu 
1               5               


<210>  14
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 HFR1

<400>  14

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser 
            20                  25  


<210>  15
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 HFR2

<400>  15

Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 HFR3

<400>  16

Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  17
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 HFR4

<400>  17

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 LCDR1

<400>  18

Gln Thr Leu Val Tyr Ser Asn Gly Asp Thr Tyr 
1               5                   10      


<210>  19
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 LCDR2

<400>  19

Lys Leu Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 LCDR3

<400>  20

Phe Gln Gly Ser Tyr Phe Pro Phe Thr 
1               5                   


<210>  21
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 HCDR1

<400>  21

Gly Tyr Ala Phe Thr Asn Tyr Phe 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 HCDR2

<400>  22

Ile Asn Pro Gly Asn Ser Asn Thr 
1               5               


<210>  23
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 HCDR3

<400>  23

Ala Arg Ser Gly Thr Thr Ala Thr Thr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  24
<211>  26
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 LFR1

<400>  24

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  25
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 LFR2

<400>  25

Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  26
<211>  36
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 LFR3

<400>  26

Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ser Glu Asp Leu Gly 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  27
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 LFR4

<400>  27

Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
1               5                   10                   
   

<210>  28
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 HFR1

<400>  28

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  29
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 HFR2

<400>  29

Ile Glu Trp Val Ile Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Val 
    


<210>  30
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 HFR3

<400>  30

Asn Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Asp Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  31
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 HFR4

<400>  31

Trp Gly Gln Gly Thr Ser Val Ile Val Ser Ser 
1               5                   10      


<210>  32
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 HCDR1

<400>  32

Gly Phe Thr Phe Arg Gly Tyr Ala 
1               5               


<210>  33
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 HCDR2

<400>  33

Ile Ser Thr Gly Gly Asn Thr 
1               5           


<210>  34
<211>  4
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 HCDR3

<400>  34

Ser Ser Pro Tyr 
1               


<210>  35
<211>  28
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 LFR1

<400>  35

Glu Leu Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
1               5                   10                  15      


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
            20                  25              


<210>  36
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 LFR4

<400>  36

Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  37
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 HFR1

<400>  37

Glu Val Lys Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  38
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 HFR2

<400>  38

Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  15      


Ser 
    


<210>  39
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 HFR3

<400>  39

Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Arg Asn Ile Leu Tyr Leu Gln Met Ser Arg Leu Arg Ser Asp Asp 
            20                  25                  30          


Thr Ala Ile Tyr Phe Cys 
        35              


<210>  40
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 HFR4

<400>  40

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro 
1               5                   10                  15      


Pro Ser Val 
            


<210>  41
<211>  252
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 VLᣩ

<400>  41
atgacttgca gggccagctc aagtgtaagt tacatgcact ggtaccagca gaagccagga       60

tcttccccca aaccctggat ttatgccaca tccaacctgg cttctggagt ccctgctcgc      120

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgaa      180

gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg      240

accaagctgg aa                                                          252


<210>  42
<211>  84
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 VL

<400>  42

Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln 
1               5                   10                  15      


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
            20                  25                  30          


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        35                  40                  45              


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
    50                  55                  60                  


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly 
65                  70                  75                  80  


Thr Lys Leu Glu 
                


<210>  43
<211>  336
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 VL (ᣩ

<400>  43
gatattgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagtctcc       60

atctcttgca gatctagtca gacccttgtg tatagtaatg gagacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaactttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg agtctgagga tctgggagtt tattactgct ttcagggttc atattttcca      300

ttcacgttcg gcgcggggac caaactggaa atcaaa                                336


<210>  44
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 VL

<400>  44

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Thr Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ser Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser Tyr Phe Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  45
<211>  324
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 VL (ᣩ

<400>  45
gagctcgata ttgttctctc ccagtctcca gcaatcctgt ctgcatctcc aggggagaag       60

gtcacaatga cttgcagggc cagctcaagt gtaagttaca tgcactggta ccagcagaag      120

ccaggatcct cccccaaacc ctggatttat gccacatcca acctggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagagtggag      240

gctgaagatg ctgccactta ttactgccag cagtggagta gtaacccatt cacgttcggc      300

tcggggacca agctggagct gaaa                                             324


<210>  46
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 VL

<400>  46

Glu Leu Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
1               5                   10                  15      


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  47
<211>  357
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 VH (ᣩ

<400>  47
gaggtccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaaga cttctggata cacattcact gaatacacca tgcactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggaggt attaatccta acaatggtgg tactagctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggat tctgcagtct attactgtgc aagagggggg      300

gggtactacg gctacgggga ctactggggt caaggaacct cagtcaccgt ctcctca         357


<210>  48
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 VH

<400>  48

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Tyr Tyr Gly Tyr Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  49
<211>  363
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 VH (ᣩ

<400>  49
gaggttcagc ttcagcagtc tggagctgag ctggtaaggc ctgggacttc agtgaaggtg       60

tcctgcaagg cttctggata cgccttcact aattacttca tagagtgggt aatacagagg      120

cctggacagg gccttgagtg gattggagtg attaatcctg gaaatagtaa tactaactac      180

aatgagaagt tcaagggcaa ggcaacactg actgcggaca aatcctccag cactgcctac      240

atgcagctca gcagcctgac atctgatgac tctgcggtct atttctgtgc aagatcgggg      300

actacggcta cgacctatgc tatggactac tggggtcaag gaacctcagt catcgtctcc      360

tca                                                                    363


<210>  50
<211>  121
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 VH

<400>  50

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Phe Ile Glu Trp Val Ile Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asn Ser Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Thr Thr Ala Thr Thr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Ile Val Ser Ser 
        115                 120     


<210>  51
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 VH (ᣩ

<400>  51
gaggtgaagg tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcttgtacag cctctggatt cactttcaga ggctatgcct tatcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcttcc attagtactg gtggtaatac ttactatcca      180

gacagtgtga agggccgatt caccatctcc agagataatg ccaggaacat cctgtacctt      240

caaatgagca ggctgaggtc tgatgacacg gccatttatt tctgttcctc tccttactgg      300

ggccaaggga ctctggtcac tgtctctgca gccaaaacaa cacccccatc tgtc            354


<210>  52
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 VH

<400>  52

Glu Val Lys Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Arg Gly Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Arg Leu Arg Ser Asp Asp Thr Ala Ile Tyr Phe Cys Ser 
                85                  90                  95      


Ser Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys 
            100                 105                 110         


Thr Thr Pro Pro Ser Val 
        115             


<210>  53
<211>  45
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VL-VH ᣩ

<400>  53
ggcggcggag gatctggcgg aggtggcagc ggaggcggtg gatct                       45


<210>  54
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL-VH

<400>  54

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  55
<211>  654
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 scFv (ᣩ

<400>  55
atgacttgca gggccagctc aagtgtaagt tacatgcact ggtaccagca gaagccagga       60

tcttccccca aaccctggat ttatgccaca tccaacctgg cttctggagt ccctgctcgc      120

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgaa      180

gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg      240

accaagctgg aaggcggcgg aggatctggc ggaggtggca gcggaggcgg tggatctgag      300

gtccagctgc agcagtctgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc      360

tgcaagactt ctggatacac attcactgaa tacaccatgc actgggtgaa gcagagccat      420

ggaaagagcc ttgagtggat tggaggtatt aatcctaaca atggtggtac tagctacaac      480

cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      540

gagctccgca gcctgacatc tgaggattct gcagtctatt actgtgcaag aggggggggg      600

tactacggct acggggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            654


<210>  56
<211>  218
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  25C5-2 scFv

<400>  56

Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln 
1               5                   10                  15      


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
            20                  25                  30          


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        35                  40                  45              


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
    50                  55                  60                  


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly 
65                  70                  75                  80  


Thr Lys Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                85                  90                  95      


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            100                 105                 110         


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        115                 120                 125             


Thr Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    130                 135                 140                 


Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn 
145                 150                 155                 160 


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                165                 170                 175     


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            180                 185                 190         


Tyr Tyr Cys Ala Arg Gly Gly Gly Tyr Tyr Gly Tyr Gly Asp Tyr Trp 
        195                 200                 205             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    210                 215             


<210>  57
<211>  744
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 scFv ᣩ

<400>  57
gatattgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagtctcc       60

atctcttgca gatctagtca gacccttgtg tatagtaatg gagacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaactttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg agtctgagga tctgggagtt tattactgct ttcagggttc atattttcca      300

ttcacgttcg gcgcggggac caaactggaa atcaaaggcg gcggaggatc tggcggaggt      360

ggcagcggag gcggtggatc tgaggttcag cttcagcagt ctggagctga gctggtaagg      420

cctgggactt cagtgaaggt gtcctgcaag gcttctggat acgccttcac taattacttc      480

atagagtggg taatacagag gcctggacag ggccttgagt ggattggagt gattaatcct      540

ggaaatagta atactaacta caatgagaag ttcaagggca aggcaacact gactgcggac      600

aaatcctcca gcactgccta catgcagctc agcagcctga catctgatga ctctgcggtc      660

tatttctgtg caagatcggg gactacggct acgacctatg ctatggacta ctggggtcaa      720

ggaacctcag tcatcgtctc ctca                                             744


<210>  58
<211>  248
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  10H10-1 scFv

<400>  58

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Thr Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ser Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser Tyr Phe Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr Phe 
145                 150                 155                 160 


Ile Glu Trp Val Ile Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Asn Pro Gly Asn Ser Asn Thr Asn Tyr Asn Glu Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Ser Gly Thr Thr Ala Thr Thr Tyr Ala Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Ser Val Ile Val Ser Ser 
                245             


<210>  59
<211>  723
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 scFv (ᣩ

<400>  59
gagctcgata ttgttctctc ccagtctcca gcaatcctgt ctgcatctcc aggggagaag       60

gtcacaatga cttgcagggc cagctcaagt gtaagttaca tgcactggta ccagcagaag      120

ccaggatcct cccccaaacc ctggatttat gccacatcca acctggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagagtggag      240

gctgaagatg ctgccactta ttactgccag cagtggagta gtaacccatt cacgttcggc      300

tcggggacca agctggagct gaaaggcggc ggaggatctg gcggaggtgg cagcggaggc      360

ggtggatctg aggtgaaggt ggtggagtct gggggaggct tagtgaagcc tggagggtcc      420

ctgaaactct cttgtacagc ctctggattc actttcagag gctatgcctt atcttgggtt      480

cgccagactc cagagaagag gctggagtgg gtcgcttcca ttagtactgg tggtaatact      540

tactatccag acagtgtgaa gggccgattc accatctcca gagataatgc caggaacatc      600

ctgtaccttc aaatgagcag gctgaggtct gatgacacgg ccatttattt ctgttcctct      660

ccttactggg gccaagggac tctggtcact gtctctgcag ccaaaacaac acccccatct      720

gtc                                                                    723


<210>  60
<211>  241
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  16F10 scFv

<400>  60

Glu Leu Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
1               5                   10                  15      


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Val Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser 
    130                 135                 140                 


Cys Thr Ala Ser Gly Phe Thr Phe Arg Gly Tyr Ala Leu Ser Trp Val 
145                 150                 155                 160 


Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr 
                165                 170                 175     


Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu Gln Met Ser Arg Leu 
        195                 200                 205             


Arg Ser Asp Asp Thr Ala Ile Tyr Phe Cys Ser Ser Pro Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 
225                 230                 235                 240 


Val 
    


<210>  61
<211>  141
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD8ᣩ

<400>  61
gaattcacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag       60

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      120

gggctggact tcgcctgtga t                                                141


<210>  62
<211>  47
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8

<400>  62

Glu Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45          


<210>  63
<211>  42
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  IgG4ᣩ

<400>  63
gaattcgaga gcaagtacgg ccccccctgc cccccctgcc cc                          42


<210>  64
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IgG4

<400>  64

Glu Phe Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10                  


<210>  65
<211>  72
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD8-1Ĥᣩ

<400>  65
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  66
<211>  24
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8-1Ĥ

<400>  66

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  67
<211>  63
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD8-2Ĥᣩ

<400>  67
atctacatct gggcccccct ggccggcacc tgcggcgtgc tgctgctgag cctggtgatc       60

acc                                                                     63


<210>  68
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8-2Ĥ

<400>  68

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  69
<211>  126
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  4-1BB (ᣩ

<400>  69
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag       60

accacccagg aggaggacgg ctgtagctgc cgcttccccg aggaggagga gggcggctgc      120

gagctg                                                                 126


<210>  70
<211>  42
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4-1BB

<400>  70

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  71
<211>  108
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  OX40ᣩ

<400>  71
cgcgaccagc gcctgccccc cgacgcccac aagccccccg gcggcggcag cttccgcacc       60

cccatccagg aggagcaggc cgacgcccac agcaccctgg ccaagatc                   108


<210>  72
<211>  36
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  OX40

<400>  72

Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly 
1               5                   10                  15      


Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr 
            20                  25                  30          


Leu Ala Lys Ile 
        35      


<210>  73
<211>  339
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD3ƣᣩ

<400>  73
cgcgtgaaat ttagccgcag cgccgacgcc cccgcctacc agcagggcca gaaccagctg       60

tacaacgagc tgaacctggg ccgccgcgag gagtacgacg tgctggacaa gcgccggggc      120

cgcgaccccg agatgggcgg caagccccag cgccgcaaga acccccagga gggcctgtac      180

aacgagctgc agaaggacaa gatggccgaa gcctacagcg agatcggcat gaagggcgag      240

cgccgccggg gcaagggcca cgacggcctg taccagggcc tgagcaccgc caccaaggac      300

acctacgacg ccctgcacat gcaggccctg cccccccgc                             339


<210>  74
<211>  113
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD3

<400>  74

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


