                         SEQUENCE LISTING

<110>  ADAERATA, LIMITED PARTNERSHIP
 
<120>  METHOD OF REDUCING NEURONAL MICROTUBULE BINDING PROTEIN TAU (TAU)
        LEVELS

<130>  G12810-000692

<140>  N.A.
<141>  2019-11-15

<150>  62/775,520
<151>  2018-12-05

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  651
<212>  PRT
<213>  homo sapiens

<400>  1

Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Ala Asn Gly 
        355                 360                 365             


Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro Ala His Thr Ala Leu 
    370                 375                 380                 


Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn Pro Trp Ala His Ala 
385                 390                 395                 400 


Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr Cys Ser Gly Thr Glu 
                405                 410                 415     


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
            420                 425                 430         


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
        435                 440                 445             


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
    450                 455                 460                 


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
465                 470                 475                 480 


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
                485                 490                 495     


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
            500                 505                 510         


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
        515                 520                 525             


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
    530                 535                 540                 


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
545                 550                 555                 560 


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
                565                 570                 575     


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
            580                 585                 590         


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
        595                 600                 605             


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
    610                 615                 620                 


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
625                 630                 635                 640 


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
                645                 650     


<210>  2
<211>  3647
<212>  DNA
<213>  homo sapiens

<400>  2
gttgtcatgg gggaggtggt ggcgcttggt ggccactggc ggccgaggta gaggcagtgg       60

cgcttgagtt ggtcgggggc agcggcagat ttgaggctta agcaacttct tccggggaag      120

agtgccagtg cagccactgt tacaattcaa gatcttgatc tatatccata gattggaata      180

ttggtgggcc agcaatcctc agacgcctca cttaggacaa atgaggaaac tgaggcttgg      240

tgaagttacg aaacttgtcc aaaatcacac aacttgtaaa gggcacagcc aagattcaga      300

gccaggctgt aaaaattaaa atgaacaaat tacggcaaag ttttaggaga aagaaggatg      360

tttatgttcc agaggccagt cgtccacatc agtggcagac agatgaagaa ggcgttcgca      420

ccggaaaatg tagcttcccg gttaagtacc ttggccatgt agaagttgat gaatcaagag      480

gaatgcacat ctgtgaagat gctgtaaaaa gattgaaagc tgaaaggaag ttcttcaaag      540

gcttctttgg aaaaactgga aagaaagcag ttaaagcagt tctgtgggtc tcagcagatg      600

gactcagagt tgtggatgaa aaaactaagg acctcatagt tgaccagacg atagagaaag      660

tttctttctg tgccccagac aggaactttg atagagcctt ttcttacata tgccgtgatg      720

gcaccactcg tcgctggatc tgtcactgct tcatggctgt caaggacaca ggtgaaaggt      780

tgagccatgc agtaggctgt gcttttgcag cctgtttaga gcgcaagcag aagcgggaga      840

aggaatgtgg agtgactgct acttttgatg ctagtcggac cacttttaca agagaaggat      900

cattccgtgt cacaacagcc actgaacaag cagaaagaga ggagatcatg aaacaaatgc      960

aagatgccaa gaaagctgaa acagataaga tagtcgttgg ttcatcagtt gcccctggca     1020

acactgcccc atccccatcc tctcccacct ctcctacttc tgatgccacg acctctctgg     1080

agatgaacaa tcctcatgcc atcccacgcc ggcatgctcc aattgaacag cttgctcgcc     1140

aaggctcttt ccgaggtttt cctgctctta gccagaagat gtcacccttt aaacgccaac     1200

tatccctacg catcaatgag ttgccttcca ctatgcagag gaagactgat ttccccatta     1260

aaaatgcagt gccagaagta gaaggggagg cagagagcat cagctccctg tgctcacaga     1320

tcaccaatgc cttcagcaca cctgaggacc ccttctcatc tgctccgatg accaaaccag     1380

tgacagtggt ggcaccacaa tctcctacct tccaagctaa tggcactgac tcagccttcc     1440

atgtgcttgc taagccagcc catactgctc tagcacccgt agcaatgcct gtgcgtgaaa     1500

ccaacccttg ggcccatgcc cctgatgctg ctaacaagga aattgcagcc acatgttcgg     1560

ggaccgagtg gggtcaatct tctggtgctg cctctccagg tctcttccag gccggtcata     1620

gacgtactcc ctctgaggcc gaccgatggt tagaagaggt gtctaagagc gtccgggctc     1680

agcagcccca ggcctcagct gctcctctgc agccagttct ccagcctcct ccacccactg     1740

ccatctccca gccagcatca cctttccaag ggaatgcatt cctcacctct cagcctgtgc     1800

cagtgggtgt ggtcccagcc ctgcaaccag cctttgtccc tgcccagtcc tatcctgtgg     1860

ccaatggaat gccctatcca gcccctaatg tgcctgtggt gggcatcact ccctcccaga     1920

tggtggccaa cgtatttggc actgcaggcc accctcaggc tgcccatccc catcagtcac     1980

ccagcctggt caggcagcag acattccctc actacgaggc aagcagtgct accaccagtc     2040

ccttctttaa gcctcctgct cagcacctca acggttctgc agctttcaat ggtgtagatg     2100

atggcaggtt ggcctcagca gacaggcata cagaggttcc tacaggcacc tgcccagtgg     2160

atccttttga agcccagtgg gctgcattag aaaataagtc caagcagcgt actaatccct     2220

cccctaccaa ccctttctcc agtgacttac agaagacgtt tgaaattgaa ctttaagcaa     2280

tcattatggc tatgtatctt gtccatacca gacagggagc agggggtagc ggtcaaagga     2340

gcaaaacaga ctttgtctcc tgattagtac tcttttcact aatcccaaag gtcccaagga     2400

acaagtccag gcccagagta ctgtgagggg tgattttgaa agacatggga aaaagcattc     2460

ctagagaaaa gctgccttgc aattaggcta aagaagtcaa ggaaatgttg ctttctgtac     2520

tccctcttcc cttaccccct tacaaatctc tggcaacaga gaggcaaagt atctgaacaa     2580

gaatctatat tccaagcaca tttactgaaa tgtaaaacac aacaggaagc aaagcaatct     2640

ccctttgttt ttcaggccat tcacctgcct cctgtcagta gtggcctgta ttagagatca     2700

agaagagtgg tttgtgctca ggctggggaa cagagaggca cgctatgctg ccagaattcc     2760

caggagggca tatcagcaac tgcccagcag agctatattt tgggggagaa gttgagcttc     2820

cattttgagt aacagaataa atattatata tatcaaaagc caaaatcttt atttttatgc     2880

atttagaata ttttaaatag ttctcagata ttaagaagtt gtatgagttg taagtaatct     2940

tgccaaaggt aaaggggcta gttgtaagaa attgtacata agattgattt atcattgatg     3000

cctactgaaa taaaaagagg aaaggctgga agctgcagac aggatcccta gcttgttttc     3060

tgtcagtcat tcattgtaag tagcacattg caacaacaat catgcttatg accaatacag     3120

tcactaggtt gtagtttttt ttaaataaag gaaaagcagt attgtcctgg ttttaaacct     3180

atgatggaat tctaatgtca ttattttaat ggaatcaatc gaaatatgct ctatagagaa     3240

tatatctttt atatattgct gcagtttcct tatgttaatc ctttaacact aaggtaacat     3300

gacataatca taccatagaa gggaacacag gttaccatat tggtttgtaa tatgggtctt     3360

ggtgggtttt gttttatcct ttaaattttg ttcccatgag ttttgtgggg atggggattc     3420

tggttttatt agctttgtgt gtgtcctctt cccccaaacc cccttttggt gagaacatcc     3480

ccttgacagt tgcagcctct tgacctcgga taacaataag agagctcatc tcatttttac     3540

ttttgaacgt tggccttaca atcaaatgta agttatatat atttgtactg atgaaaattt     3600

ataatctgct ttaacaaaaa taaatgttca tggtagaagc ttttaaa                   3647


<210>  3
<211>  603
<212>  PRT
<213>  homo sapiens

<400>  3

Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Gly Thr Glu 
        355                 360                 365             


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
    370                 375                 380                 


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
385                 390                 395                 400 


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
                405                 410                 415     


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
            420                 425                 430         


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
        435                 440                 445             


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
    450                 455                 460                 


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
465                 470                 475                 480 


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
                485                 490                 495     


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
            500                 505                 510         


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
        515                 520                 525             


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
    530                 535                 540                 


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
545                 550                 555                 560 


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
                565                 570                 575     


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
            580                 585                 590         


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
        595                 600             


<210>  4
<211>  161
<212>  PRT
<213>  homo sapiens

<400>  4

Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
1               5                   10                  15      


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
            20                  25                  30          


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
        35                  40                  45              


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
    50                  55                  60                  


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
65                  70                  75                  80  


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
                85                  90                  95      


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
            100                 105                 110         


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
        115                 120                 125             


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
    130                 135                 140                 


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
145                 150                 155                 160 


Gly 
    


<210>  5
<211>  3503
<212>  DNA
<213>  homo sapiens

<400>  5
gttgtcatgg gggaggtggt ggcgcttggt ggccactggc ggccgaggta gaggcagtgg       60

cgcttgagtt ggtcgggggc agcggcagat ttgaggctta agcaacttct tccggggaag      120

agtgccagtg cagccactgt tacaattcaa gatcttgatc tatatccata gattggaata      180

ttggtgggcc agcaatcctc agacgcctca cttaggacaa atgaggaaac tgaggcttgg      240

tgaagttacg aaacttgtcc aaaatcacac aacttgtaaa gggcacagcc aagattcaga      300

gccaggctgt aaaaattaaa atgaacaaat tacggcaaag ttttaggaga aagaaggatg      360

tttatgttcc agaggccagt cgtccacatc agtggcagac agatgaagaa ggcgttcgca      420

ccggaaaatg tagcttcccg gttaagtacc ttggccatgt agaagttgat gaatcaagag      480

gaatgcacat ctgtgaagat gctgtaaaaa gattgaaagc tgaaaggaag ttcttcaaag      540

gcttctttgg aaaaactgga aagaaagcag ttaaagcagt tctgtgggtc tcagcagatg      600

gactcagagt tgtggatgaa aaaactaagg acctcatagt tgaccagacg atagagaaag      660

tttctttctg tgccccagac aggaactttg atagagcctt ttcttacata tgccgtgatg      720

gcaccactcg tcgctggatc tgtcactgct tcatggctgt caaggacaca ggtgaaaggt      780

tgagccatgc agtaggctgt gcttttgcag cctgtttaga gcgcaagcag aagcgggaga      840

aggaatgtgg agtgactgct acttttgatg ctagtcggac cacttttaca agagaaggat      900

cattccgtgt cacaacagcc actgaacaag cagaaagaga ggagatcatg aaacaaatgc      960

aagatgccaa gaaagctgaa acagataaga tagtcgttgg ttcatcagtt gcccctggca     1020

acactgcccc atccccatcc tctcccacct ctcctacttc tgatgccacg acctctctgg     1080

agatgaacaa tcctcatgcc atcccacgcc ggcatgctcc aattgaacag cttgctcgcc     1140

aaggctcttt ccgaggtttt cctgctctta gccagaagat gtcacccttt aaacgccaac     1200

tatccctacg catcaatgag ttgccttcca ctatgcagag gaagactgat ttccccatta     1260

aaaatgcagt gccagaagta gaaggggagg cagagagcat cagctccctg tgctcacaga     1320

tcaccaatgc cttcagcaca cctgaggacc ccttctcatc tgctccgatg accaaaccag     1380

tgacagtggt ggcaccacaa tctcctacct tccaagggac cgagtggggt caatcttctg     1440

gtgctgcctc tccaggtctc ttccaggccg gtcatagacg tactccctct gaggccgacc     1500

gatggttaga agaggtgtct aagagcgtcc gggctcagca gccccaggcc tcagctgctc     1560

ctctgcagcc agttctccag cctcctccac ccactgccat ctcccagcca gcatcacctt     1620

tccaagggaa tgcattcctc acctctcagc ctgtgccagt gggtgtggtc ccagccctgc     1680

aaccagcctt tgtccctgcc cagtcctatc ctgtggccaa tggaatgccc tatccagccc     1740

ctaatgtgcc tgtggtgggc atcactccct cccagatggt ggccaacgta tttggcactg     1800

caggccaccc tcaggctgcc catccccatc agtcacccag cctggtcagg cagcagacat     1860

tccctcacta cgaggcaagc agtgctacca ccagtccctt ctttaagcct cctgctcagc     1920

acctcaacgg ttctgcagct ttcaatggtg tagatgatgg caggttggcc tcagcagaca     1980

ggcatacaga ggttcctaca ggcacctgcc cagtggatcc ttttgaagcc cagtgggctg     2040

cattagaaaa taagtccaag cagcgtacta atccctcccc taccaaccct ttctccagtg     2100

acttacagaa gacgtttgaa attgaacttt aagcaatcat tatggctatg tatcttgtcc     2160

ataccagaca gggagcaggg ggtagcggtc aaaggagcaa aacagacttt gtctcctgat     2220

tagtactctt ttcactaatc ccaaaggtcc caaggaacaa gtccaggccc agagtactgt     2280

gaggggtgat tttgaaagac atgggaaaaa gcattcctag agaaaagctg ccttgcaatt     2340

aggctaaaga agtcaaggaa atgttgcttt ctgtactccc tcttccctta cccccttaca     2400

aatctctggc aacagagagg caaagtatct gaacaagaat ctatattcca agcacattta     2460

ctgaaatgta aaacacaaca ggaagcaaag caatctccct ttgtttttca ggccattcac     2520

ctgcctcctg tcagtagtgg cctgtattag agatcaagaa gagtggtttg tgctcaggct     2580

ggggaacaga gaggcacgct atgctgccag aattcccagg agggcatatc agcaactgcc     2640

cagcagagct atattttggg ggagaagttg agcttccatt ttgagtaaca gaataaatat     2700

tatatatatc aaaagccaaa atctttattt ttatgcattt agaatatttt aaatagttct     2760

cagatattaa gaagttgtat gagttgtaag taatcttgcc aaaggtaaag gggctagttg     2820

taagaaattg tacataagat tgatttatca ttgatgccta ctgaaataaa aagaggaaag     2880

gctggaagct gcagacagga tccctagctt gttttctgtc agtcattcat tgtaagtagc     2940

acattgcaac aacaatcatg cttatgacca atacagtcac taggttgtag ttttttttaa     3000

ataaaggaaa agcagtattg tcctggtttt aaacctatga tggaattcta atgtcattat     3060

tttaatggaa tcaatcgaaa tatgctctat agagaatata tcttttatat attgctgcag     3120

tttccttatg ttaatccttt aacactaagg taacatgaca taatcatacc atagaaggga     3180

acacaggtta ccatattggt ttgtaatatg ggtcttggtg ggttttgttt tatcctttaa     3240

attttgttcc catgagtttt gtggggatgg ggattctggt tttattagct ttgtgtgtgt     3300

cctcttcccc caaaccccct tttggtgaga acatcccctt gacagttgca gcctcttgac     3360

ctcggataac aataagagag ctcatctcat ttttactttt gaacgttggc cttacaatca     3420

aatgtaagtt atatatattt gtactgatga aaatttataa tctgctttaa caaaaataaa     3480

tgttcatggt agaagctttt aaa                                             3503


<210>  6
<211>  640
<212>  PRT
<213>  homo sapiens

<400>  6

Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala 
        195                 200                 205             


Glu Thr Asp Lys Ile Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr 
    210                 215                 220                 


Ala Pro Ser Pro Ser Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr 
225                 230                 235                 240 


Ser Leu Glu Met Asn Asn Pro His Ala Ile Pro Arg Arg His Ala Pro 
                245                 250                 255     


Ile Glu Gln Leu Ala Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu 
            260                 265                 270         


Ser Gln Lys Met Ser Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn 
        275                 280                 285             


Glu Leu Pro Ser Thr Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn 
    290                 295                 300                 


Ala Val Pro Glu Val Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys 
305                 310                 315                 320 


Ser Gln Ile Thr Asn Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser 
                325                 330                 335     


Ala Pro Met Thr Lys Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr 
            340                 345                 350         


Phe Gln Ala Asn Gly Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro 
        355                 360                 365             


Ala His Thr Ala Leu Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn 
    370                 375                 380                 


Pro Trp Ala His Ala Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr 
385                 390                 395                 400 


Cys Ser Gly Thr Glu Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly 
                405                 410                 415     


Leu Phe Gln Ala Gly His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp 
            420                 425                 430         


Leu Glu Glu Val Ser Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser 
        435                 440                 445             


Ala Ala Pro Leu Gln Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile 
    450                 455                 460                 


Ser Gln Pro Ala Ser Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln 
465                 470                 475                 480 


Pro Val Pro Val Gly Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro 
                485                 490                 495     


Ala Gln Ser Tyr Pro Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn 
            500                 505                 510         


Val Pro Val Val Gly Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe 
        515                 520                 525             


Gly Thr Ala Gly His Pro Gln Ala Ala His Pro His Gln Ser Pro Ser 
    530                 535                 540                 


Leu Val Arg Gln Gln Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr 
545                 550                 555                 560 


Thr Ser Pro Phe Phe Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala 
                565                 570                 575     


Ala Phe Asn Gly Val Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His 
            580                 585                 590         


Thr Glu Val Pro Thr Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln 
        595                 600                 605             


Trp Ala Ala Leu Glu Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro 
    610                 615                 620                 


Thr Asn Pro Phe Ser Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
625                 630                 635                 640 


<210>  7
<211>  592
<212>  PRT
<213>  homo sapiens

<400>  7

Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala 
        195                 200                 205             


Glu Thr Asp Lys Ile Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr 
    210                 215                 220                 


Ala Pro Ser Pro Ser Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr 
225                 230                 235                 240 


Ser Leu Glu Met Asn Asn Pro His Ala Ile Pro Arg Arg His Ala Pro 
                245                 250                 255     


Ile Glu Gln Leu Ala Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu 
            260                 265                 270         


Ser Gln Lys Met Ser Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn 
        275                 280                 285             


Glu Leu Pro Ser Thr Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn 
    290                 295                 300                 


Ala Val Pro Glu Val Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys 
305                 310                 315                 320 


Ser Gln Ile Thr Asn Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser 
                325                 330                 335     


Ala Pro Met Thr Lys Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr 
            340                 345                 350         


Phe Gln Gly Thr Glu Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly 
        355                 360                 365             


Leu Phe Gln Ala Gly His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp 
    370                 375                 380                 


Leu Glu Glu Val Ser Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser 
385                 390                 395                 400 


Ala Ala Pro Leu Gln Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile 
                405                 410                 415     


Ser Gln Pro Ala Ser Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln 
            420                 425                 430         


Pro Val Pro Val Gly Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro 
        435                 440                 445             


Ala Gln Ser Tyr Pro Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn 
    450                 455                 460                 


Val Pro Val Val Gly Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe 
465                 470                 475                 480 


Gly Thr Ala Gly His Pro Gln Ala Ala His Pro His Gln Ser Pro Ser 
                485                 490                 495     


Leu Val Arg Gln Gln Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr 
            500                 505                 510         


Thr Ser Pro Phe Phe Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala 
        515                 520                 525             


Ala Phe Asn Gly Val Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His 
    530                 535                 540                 


Thr Glu Val Pro Thr Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln 
545                 550                 555                 560 


Trp Ala Ala Leu Glu Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro 
                565                 570                 575     


Thr Asn Pro Phe Ser Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
            580                 585                 590         


<210>  8
<211>  456
<212>  PRT
<213>  homo sapiens

<400>  8

Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Gly Thr Glu Trp Gly Gln 
    210                 215                 220                 


Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly His Arg Arg 
225                 230                 235                 240 


Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser Lys Ser Val 
                245                 250                 255     


Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln Pro Val Leu 
            260                 265                 270         


Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser Pro Phe Gln 
        275                 280                 285             


Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly Val Val Pro 
    290                 295                 300                 


Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro Val Ala Asn 
305                 310                 315                 320 


Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly Ile Thr Pro 
                325                 330                 335     


Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His Pro Gln Ala 
            340                 345                 350         


Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln Thr Phe Pro 
        355                 360                 365             


His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe Lys Pro Pro 
    370                 375                 380                 


Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val Asp Asp Gly 
385                 390                 395                 400 


Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr Gly Thr Cys 
                405                 410                 415     


Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu Asn Lys Ser 
            420                 425                 430         


Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser Ser Asp Leu 
        435                 440                 445             


Gln Lys Thr Phe Glu Ile Glu Leu 
    450                 455     


<210>  9
<211>  445
<212>  PRT
<213>  homo sapiens

<400>  9

Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Gly 
        195                 200                 205             


Thr Glu Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln 
    210                 215                 220                 


Ala Gly His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu 
225                 230                 235                 240 


Val Ser Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro 
                245                 250                 255     


Leu Gln Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro 
            260                 265                 270         


Ala Ser Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro 
        275                 280                 285             


Val Gly Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser 
    290                 295                 300                 


Tyr Pro Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val 
305                 310                 315                 320 


Val Gly Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala 
                325                 330                 335     


Gly His Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg 
            340                 345                 350         


Gln Gln Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro 
        355                 360                 365             


Phe Phe Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn 
    370                 375                 380                 


Gly Val Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val 
385                 390                 395                 400 


Pro Thr Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala 
                405                 410                 415     


Leu Glu Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro 
            420                 425                 430         


Phe Ser Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
        435                 440                 445 


<210>  10
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (68)..(78)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (219)..(413)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Thr Glu 
                405                 410                 415     


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
            420                 425                 430         


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
        435                 440                 445             


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
    450                 455                 460                 


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
465                 470                 475                 480 


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
                485                 490                 495     


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
            500                 505                 510         


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
        515                 520                 525             


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
    530                 535                 540                 


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
545                 550                 555                 560 


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
                565                 570                 575     


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
            580                 585                 590         


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
        595                 600                 605             


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
    610                 615                 620                 


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
625                 630                 635                 640 


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
                645                 650     


<210>  11
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (366)..(413)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Thr Glu 
                405                 410                 415     


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
            420                 425                 430         


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
        435                 440                 445             


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
    450                 455                 460                 


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
465                 470                 475                 480 


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
                485                 490                 495     


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
            500                 505                 510         


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
        515                 520                 525             


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
    530                 535                 540                 


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
545                 550                 555                 560 


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
                565                 570                 575     


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
            580                 585                 590         


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
        595                 600                 605             


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
    610                 615                 620                 


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
625                 630                 635                 640 


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
                645                 650     


<210>  12
<211>  531
<212>  PRT
<213>  homo sapiens

<400>  12

Met Asp Gly Ile Val Pro Asp Ile Ala Val Gly Thr Lys Arg Gly Ser 
1               5                   10                  15      


Asp Glu Leu Phe Ser Thr Cys Val Thr Asn Gly Pro Phe Ile Met Ser 
            20                  25                  30          


Ser Asn Ser Ala Ser Ala Ala Asn Gly Asn Asp Ser Lys Lys Phe Lys 
        35                  40                  45              


Gly Asp Ser Arg Ser Ala Gly Val Pro Ser Arg Val Ile His Ile Arg 
    50                  55                  60                  


Lys Leu Pro Ile Asp Val Thr Glu Gly Glu Val Ile Ser Leu Gly Leu 
65                  70                  75                  80  


Pro Phe Gly Lys Val Thr Asn Leu Leu Met Leu Lys Gly Lys Asn Gln 
                85                  90                  95      


Ala Phe Ile Glu Met Asn Thr Glu Glu Ala Ala Asn Thr Met Val Asn 
            100                 105                 110         


Tyr Tyr Thr Ser Val Thr Pro Val Leu Arg Gly Gln Pro Ile Tyr Ile 
        115                 120                 125             


Gln Phe Ser Asn His Lys Glu Leu Lys Thr Asp Ser Ser Pro Asn Gln 
    130                 135                 140                 


Ala Arg Ala Gln Ala Ala Leu Gln Ala Val Asn Ser Val Gln Ser Gly 
145                 150                 155                 160 


Asn Leu Ala Leu Ala Ala Ser Ala Ala Ala Val Asp Ala Gly Met Ala 
                165                 170                 175     


Met Ala Gly Gln Ser Pro Val Leu Arg Ile Ile Val Glu Asn Leu Phe 
            180                 185                 190         


Tyr Pro Val Thr Leu Asp Val Leu His Gln Ile Phe Ser Lys Phe Gly 
        195                 200                 205             


Thr Val Leu Lys Ile Ile Thr Phe Thr Lys Asn Asn Gln Phe Gln Ala 
    210                 215                 220                 


Leu Leu Gln Tyr Ala Asp Pro Val Ser Ala Gln His Ala Lys Leu Ser 
225                 230                 235                 240 


Leu Asp Gly Gln Asn Ile Tyr Asn Ala Cys Cys Thr Leu Arg Ile Asp 
                245                 250                 255     


Phe Ser Lys Leu Thr Ser Leu Asn Val Lys Tyr Asn Asn Asp Lys Ser 
            260                 265                 270         


Arg Asp Tyr Thr Arg Pro Asp Leu Pro Ser Gly Asp Ser Gln Pro Ser 
        275                 280                 285             


Leu Asp Gln Thr Met Ala Ala Ala Phe Gly Leu Ser Val Pro Asn Val 
    290                 295                 300                 


His Gly Ala Leu Ala Pro Leu Ala Ile Pro Ser Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Gly Arg Ile Ala Ile Pro Gly Leu Ala Gly Ala Gly Asn 
                325                 330                 335     


Ser Val Leu Leu Val Ser Asn Leu Asn Pro Glu Arg Val Thr Pro Gln 
            340                 345                 350         


Ser Leu Phe Ile Leu Phe Gly Val Tyr Gly Asp Val Gln Arg Val Lys 
        355                 360                 365             


Ile Leu Phe Asn Lys Lys Glu Asn Ala Leu Val Gln Met Ala Asp Gly 
    370                 375                 380                 


Asn Gln Ala Gln Leu Ala Met Ser His Leu Asn Gly His Lys Leu His 
385                 390                 395                 400 


Gly Lys Pro Ile Arg Ile Thr Leu Ser Lys His Gln Asn Val Gln Leu 
                405                 410                 415     


Pro Arg Glu Gly Gln Glu Asp Gln Gly Leu Thr Lys Asp Tyr Gly Asn 
            420                 425                 430         


Ser Pro Leu His Arg Phe Lys Lys Pro Gly Ser Lys Asn Phe Gln Asn 
        435                 440                 445             


Ile Phe Pro Pro Ser Ala Thr Leu His Leu Ser Asn Ile Pro Pro Ser 
    450                 455                 460                 


Val Ser Glu Glu Asp Leu Lys Val Leu Phe Ser Ser Asn Gly Gly Val 
465                 470                 475                 480 


Val Lys Gly Phe Lys Phe Phe Gln Lys Asp Arg Lys Met Ala Leu Ile 
                485                 490                 495     


Gln Met Gly Ser Val Glu Glu Ala Val Gln Ala Leu Ile Asp Leu His 
            500                 505                 510         


Asn His Asp Leu Gly Glu Asn His His Leu Arg Val Ser Phe Ser Lys 
        515                 520                 525             


Ser Thr Ile 
    530     


<210>  13
<211>  550
<212>  PRT
<213>  homo sapiens

<400>  13

Met Asp Gly Ile Val Pro Asp Ile Ala Val Gly Thr Lys Arg Gly Ser 
1               5                   10                  15      


Asp Glu Leu Phe Ser Thr Cys Val Thr Asn Gly Pro Phe Ile Met Ser 
            20                  25                  30          


Ser Asn Ser Ala Ser Ala Ala Asn Gly Asn Asp Ser Lys Lys Phe Lys 
        35                  40                  45              


Gly Asp Ser Arg Ser Ala Gly Val Pro Ser Arg Val Ile His Ile Arg 
    50                  55                  60                  


Lys Leu Pro Ile Asp Val Thr Glu Gly Glu Val Ile Ser Leu Gly Leu 
65                  70                  75                  80  


Pro Phe Gly Lys Val Thr Asn Leu Leu Met Leu Lys Gly Lys Asn Gln 
                85                  90                  95      


Ala Phe Ile Glu Met Asn Thr Glu Glu Ala Ala Asn Thr Met Val Asn 
            100                 105                 110         


Tyr Tyr Thr Ser Val Thr Pro Val Leu Arg Gly Gln Pro Ile Tyr Ile 
        115                 120                 125             


Gln Phe Ser Asn His Lys Glu Leu Lys Thr Asp Ser Ser Pro Asn Gln 
    130                 135                 140                 


Ala Arg Ala Gln Ala Ala Leu Gln Ala Val Asn Ser Val Gln Ser Gly 
145                 150                 155                 160 


Asn Leu Ala Leu Ala Ala Ser Ala Ala Ala Val Asp Ala Gly Met Ala 
                165                 170                 175     


Met Ala Gly Gln Ser Pro Val Leu Arg Ile Ile Val Glu Asn Leu Phe 
            180                 185                 190         


Tyr Pro Val Thr Leu Asp Val Leu His Gln Ile Phe Ser Lys Phe Gly 
        195                 200                 205             


Thr Val Leu Lys Ile Ile Thr Phe Thr Lys Asn Asn Gln Phe Gln Ala 
    210                 215                 220                 


Leu Leu Gln Tyr Ala Asp Pro Val Ser Ala Gln His Ala Lys Leu Ser 
225                 230                 235                 240 


Leu Asp Gly Gln Asn Ile Tyr Asn Ala Cys Cys Thr Leu Arg Ile Asp 
                245                 250                 255     


Phe Ser Lys Leu Thr Ser Leu Asn Val Lys Tyr Asn Asn Asp Lys Ser 
            260                 265                 270         


Arg Asp Tyr Thr Arg Pro Asp Leu Pro Ser Gly Asp Ser Gln Pro Ser 
        275                 280                 285             


Leu Asp Gln Thr Met Ala Ala Ala Phe Ala Ser Pro Tyr Ala Gly Ala 
    290                 295                 300                 


Gly Phe Pro Pro Thr Phe Ala Ile Pro Gln Ala Ala Gly Leu Ser Val 
305                 310                 315                 320 


Pro Asn Val His Gly Ala Leu Ala Pro Leu Ala Ile Pro Ser Ala Ala 
                325                 330                 335     


Ala Ala Ala Ala Ala Ala Gly Arg Ile Ala Ile Pro Gly Leu Ala Gly 
            340                 345                 350         


Ala Gly Asn Ser Val Leu Leu Val Ser Asn Leu Asn Pro Glu Arg Val 
        355                 360                 365             


Thr Pro Gln Ser Leu Phe Ile Leu Phe Gly Val Tyr Gly Asp Val Gln 
    370                 375                 380                 


Arg Val Lys Ile Leu Phe Asn Lys Lys Glu Asn Ala Leu Val Gln Met 
385                 390                 395                 400 


Ala Asp Gly Asn Gln Ala Gln Leu Ala Met Ser His Leu Asn Gly His 
                405                 410                 415     


Lys Leu His Gly Lys Pro Ile Arg Ile Thr Leu Ser Lys His Gln Asn 
            420                 425                 430         


Val Gln Leu Pro Arg Glu Gly Gln Glu Asp Gln Gly Leu Thr Lys Asp 
        435                 440                 445             


Tyr Gly Asn Ser Pro Leu His Arg Phe Lys Lys Pro Gly Ser Lys Asn 
    450                 455                 460                 


Phe Gln Asn Ile Phe Pro Pro Ser Ala Thr Leu His Leu Ser Asn Ile 
465                 470                 475                 480 


Pro Pro Ser Val Ser Glu Glu Asp Leu Lys Val Leu Phe Ser Ser Asn 
                485                 490                 495     


Gly Gly Val Val Lys Gly Phe Lys Phe Phe Gln Lys Asp Arg Lys Met 
            500                 505                 510         


Ala Leu Ile Gln Met Gly Ser Val Glu Glu Ala Val Gln Ala Leu Ile 
        515                 520                 525             


Asp Leu His Asn His Asp Leu Gly Glu Asn His His Leu Arg Val Ser 
    530                 535                 540                 


Phe Ser Lys Ser Thr Ile 
545                 550 


<210>  14
<211>  557
<212>  PRT
<213>  homo sapiens

<400>  14

Met Asp Gly Ile Val Pro Asp Ile Ala Val Gly Thr Lys Arg Gly Ser 
1               5                   10                  15      


Asp Glu Leu Phe Ser Thr Cys Val Thr Asn Gly Pro Phe Ile Met Ser 
            20                  25                  30          


Ser Asn Ser Ala Ser Ala Ala Asn Gly Asn Asp Ser Lys Lys Phe Lys 
        35                  40                  45              


Gly Asp Ser Arg Ser Ala Gly Val Pro Ser Arg Val Ile His Ile Arg 
    50                  55                  60                  


Lys Leu Pro Ile Asp Val Thr Glu Gly Glu Val Ile Ser Leu Gly Leu 
65                  70                  75                  80  


Pro Phe Gly Lys Val Thr Asn Leu Leu Met Leu Lys Gly Lys Asn Gln 
                85                  90                  95      


Ala Phe Ile Glu Met Asn Thr Glu Glu Ala Ala Asn Thr Met Val Asn 
            100                 105                 110         


Tyr Tyr Thr Ser Val Thr Pro Val Leu Arg Gly Gln Pro Ile Tyr Ile 
        115                 120                 125             


Gln Phe Ser Asn His Lys Glu Leu Lys Thr Asp Ser Ser Pro Asn Gln 
    130                 135                 140                 


Ala Arg Ala Gln Ala Ala Leu Gln Ala Val Asn Ser Val Gln Ser Gly 
145                 150                 155                 160 


Asn Leu Ala Leu Ala Ala Ser Ala Ala Ala Val Asp Ala Gly Met Ala 
                165                 170                 175     


Met Ala Gly Gln Ser Pro Val Leu Arg Ile Ile Val Glu Asn Leu Phe 
            180                 185                 190         


Tyr Pro Val Thr Leu Asp Val Leu His Gln Ile Phe Ser Lys Phe Gly 
        195                 200                 205             


Thr Val Leu Lys Ile Ile Thr Phe Thr Lys Asn Asn Gln Phe Gln Ala 
    210                 215                 220                 


Leu Leu Gln Tyr Ala Asp Pro Val Ser Ala Gln His Ala Lys Leu Ser 
225                 230                 235                 240 


Leu Asp Gly Gln Asn Ile Tyr Asn Ala Cys Cys Thr Leu Arg Ile Asp 
                245                 250                 255     


Phe Ser Lys Leu Thr Ser Leu Asn Val Lys Tyr Asn Asn Asp Lys Ser 
            260                 265                 270         


Arg Asp Tyr Thr Arg Pro Asp Leu Pro Ser Gly Asp Ser Gln Pro Ser 
        275                 280                 285             


Leu Asp Gln Thr Met Ala Ala Ala Phe Gly Ala Pro Gly Ile Ile Ser 
    290                 295                 300                 


Ala Ser Pro Tyr Ala Gly Ala Gly Phe Pro Pro Thr Phe Ala Ile Pro 
305                 310                 315                 320 


Gln Ala Ala Gly Leu Ser Val Pro Asn Val His Gly Ala Leu Ala Pro 
                325                 330                 335     


Leu Ala Ile Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Ile 
            340                 345                 350         


Ala Ile Pro Gly Leu Ala Gly Ala Gly Asn Ser Val Leu Leu Val Ser 
        355                 360                 365             


Asn Leu Asn Pro Glu Arg Val Thr Pro Gln Ser Leu Phe Ile Leu Phe 
    370                 375                 380                 


Gly Val Tyr Gly Asp Val Gln Arg Val Lys Ile Leu Phe Asn Lys Lys 
385                 390                 395                 400 


Glu Asn Ala Leu Val Gln Met Ala Asp Gly Asn Gln Ala Gln Leu Ala 
                405                 410                 415     


Met Ser His Leu Asn Gly His Lys Leu His Gly Lys Pro Ile Arg Ile 
            420                 425                 430         


Thr Leu Ser Lys His Gln Asn Val Gln Leu Pro Arg Glu Gly Gln Glu 
        435                 440                 445             


Asp Gln Gly Leu Thr Lys Asp Tyr Gly Asn Ser Pro Leu His Arg Phe 
    450                 455                 460                 


Lys Lys Pro Gly Ser Lys Asn Phe Gln Asn Ile Phe Pro Pro Ser Ala 
465                 470                 475                 480 


Thr Leu His Leu Ser Asn Ile Pro Pro Ser Val Ser Glu Glu Asp Leu 
                485                 490                 495     


Lys Val Leu Phe Ser Ser Asn Gly Gly Val Val Lys Gly Phe Lys Phe 
            500                 505                 510         


Phe Gln Lys Asp Arg Lys Met Ala Leu Ile Gln Met Gly Ser Val Glu 
        515                 520                 525             


Glu Ala Val Gln Ala Leu Ile Asp Leu His Asn His Asp Leu Gly Glu 
    530                 535                 540                 


Asn His His Leu Arg Val Ser Phe Ser Lys Ser Thr Ile 
545                 550                 555         


<210>  15
<211>  248
<212>  PRT
<213>  homo sapiens

<400>  15

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Gly Glu Thr Ala Tyr Ile Arg Val 
            180                 185                 190         


Lys Val Asp Gly Pro Arg Ser Pro Ser Tyr Gly Arg Ser Arg Ser Arg 
        195                 200                 205             


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Asn Ser Arg Ser Arg 
    210                 215                 220                 


Ser Tyr Ser Pro Arg Arg Ser Arg Gly Ser Pro Arg Tyr Ser Pro Arg 
225                 230                 235                 240 


His Ser Arg Ser Arg Ser Arg Thr 
                245             


<210>  16
<211>  292
<212>  PRT
<213>  homo sapiens

<400>  16

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Phe Cys Leu Ser Asn Arg Glu Lys 
            180                 185                 190         


Leu Pro Thr Ser Gly Leu Lys Leu Met Gly Pro Glu Val Gln Val Met 
        195                 200                 205             


Glu Asp Leu Asp Leu Glu Ala Val Val Val Ala Glu Ala Val Ala Glu 
    210                 215                 220                 


Ala Thr Ala Gly Val Ala Val Thr Pro Gln Gly Glu Ala Glu Asp His 
225                 230                 235                 240 


His Ala Ile Leu Pro Val Ile Ala Asp Leu Ala Leu Val His Lys Met 
                245                 250                 255     


Ile Gly Asp Thr Phe Cys Arg Thr His Val Val Tyr Ser Phe Pro Leu 
            260                 265                 270         


Phe Ser Thr Ile Phe Ser Phe Phe Asn Ser Asn Cys Phe Val Gln Asn 
        275                 280                 285             


Gly Leu Lys Cys 
    290         


<210>  17
<211>  201
<212>  PRT
<213>  homo sapiens

<400>  17

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Val Gly Tyr Thr Arg Ile Leu Phe 
            180                 185                 190         


Phe Asp Gln Asn Trp Ile Gln Trp Ser 
        195                 200     


<210>  18
<211>  758
<212>  PRT
<213>  homo sapiens

<400>  18

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Glu Pro Glu Ser 
        115                 120                 125             


Gly Lys Val Val Gln Glu Gly Phe Leu Arg Glu Pro Gly Pro Pro Gly 
    130                 135                 140                 


Leu Ser His Gln Leu Met Ser Gly Met Pro Gly Ala Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Gly Pro Arg Glu Ala Thr Arg Gln Pro Ser Gly Thr Gly Pro Glu 
                165                 170                 175     


Asp Thr Glu Gly Gly Arg His Ala Pro Glu Leu Leu Lys His Gln Leu 
            180                 185                 190         


Leu Gly Asp Leu His Gln Glu Gly Pro Pro Leu Lys Gly Ala Gly Gly 
        195                 200                 205             


Lys Glu Arg Pro Gly Ser Lys Glu Glu Val Asp Glu Asp Arg Asp Val 
    210                 215                 220                 


Asp Glu Ser Ser Pro Gln Asp Ser Pro Pro Ser Lys Ala Ser Pro Ala 
225                 230                 235                 240 


Gln Asp Gly Arg Pro Pro Gln Thr Ala Ala Arg Glu Ala Thr Ser Ile 
                245                 250                 255     


Pro Gly Phe Pro Ala Glu Gly Ala Ile Pro Leu Pro Val Asp Phe Leu 
            260                 265                 270         


Ser Lys Val Ser Thr Glu Ile Pro Ala Ser Glu Pro Asp Gly Pro Ser 
        275                 280                 285             


Val Gly Arg Ala Lys Gly Gln Asp Ala Pro Leu Glu Phe Thr Phe His 
    290                 295                 300                 


Val Glu Ile Thr Pro Asn Val Gln Lys Glu Gln Ala His Ser Glu Glu 
305                 310                 315                 320 


His Leu Gly Arg Ala Ala Phe Pro Gly Ala Pro Gly Glu Gly Pro Glu 
                325                 330                 335     


Ala Arg Gly Pro Ser Leu Gly Glu Asp Thr Lys Glu Ala Asp Leu Pro 
            340                 345                 350         


Glu Pro Ser Glu Lys Gln Pro Ala Ala Ala Pro Arg Gly Lys Pro Val 
        355                 360                 365             


Ser Arg Val Pro Gln Leu Lys Ala Arg Met Val Ser Lys Ser Lys Asp 
    370                 375                 380                 


Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Thr Ser Thr Arg Ser Ser 
385                 390                 395                 400 


Ala Lys Thr Leu Lys Asn Arg Pro Cys Leu Ser Pro Lys His Pro Thr 
                405                 410                 415     


Pro Gly Ser Ser Asp Pro Leu Ile Gln Pro Ser Ser Pro Ala Val Cys 
            420                 425                 430         


Pro Glu Pro Pro Ser Ser Pro Lys Tyr Val Ser Ser Val Thr Ser Arg 
        435                 440                 445             


Thr Gly Ser Ser Gly Ala Lys Glu Met Lys Leu Lys Gly Ala Asp Gly 
    450                 455                 460                 


Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys 
465                 470                 475                 480 


Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro 
                485                 490                 495     


Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser 
            500                 505                 510         


Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg 
        515                 520                 525             


Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
    530                 535                 540                 


Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu 
545                 550                 555                 560 


Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
                565                 570                 575     


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            580                 585                 590         


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
        595                 600                 605             


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    610                 615                 620                 


Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
625                 630                 635                 640 


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
                645                 650                 655     


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
            660                 665                 670         


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
        675                 680                 685             


Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp 
    690                 695                 700                 


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
705                 710                 715                 720 


Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met 
                725                 730                 735     


Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser 
            740                 745                 750         


Leu Ala Lys Gln Gly Leu 
        755             


<210>  19
<211>  441
<212>  PRT
<213>  homo sapiens

<400>  19

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  20
<211>  383
<212>  PRT
<213>  homo sapiens

<400>  20

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu 
    210                 215                 220                 


Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
225                 230                 235                 240 


His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp 
                245                 250                 255     


Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His 
            260                 265                 270         


Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
        275                 280                 285             


Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His 
    290                 295                 300                 


Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
305                 310                 315                 320 


Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
                325                 330                 335     


Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn 
            340                 345                 350         


Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala 
        355                 360                 365             


Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380             


<210>  21
<211>  352
<212>  PRT
<213>  homo sapiens

<400>  21

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val 
    210                 215                 220                 


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
225                 230                 235                 240 


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
                245                 250                 255     


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr 
            260                 265                 270         


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
        275                 280                 285             


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
    290                 295                 300                 


Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser 
305                 310                 315                 320 


Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu 
                325                 330                 335     


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            340                 345                 350         


<210>  22
<211>  412
<212>  PRT
<213>  homo sapiens

<400>  22

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala 
    130                 135                 140                 


Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro 
145                 150                 155                 160 


Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
                165                 170                 175     


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
            180                 185                 190         


Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
        195                 200                 205             


Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu 
    210                 215                 220                 


Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
225                 230                 235                 240 


Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser 
                245                 250                 255     


Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro 
            260                 265                 270         


Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
        275                 280                 285             


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
    290                 295                 300                 


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
305                 310                 315                 320 


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
                325                 330                 335     


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn 
            340                 345                 350         


Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
        355                 360                 365             


Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser 
    370                 375                 380                 


Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala 
385                 390                 395                 400 


Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410         


<210>  23
<211>  776
<212>  PRT
<213>  homo sapiens

<400>  23

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Glu Pro Glu Ser 
        115                 120                 125             


Gly Lys Val Val Gln Glu Gly Phe Leu Arg Glu Pro Gly Pro Pro Gly 
    130                 135                 140                 


Leu Ser His Gln Leu Met Ser Gly Met Pro Gly Ala Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Gly Pro Arg Glu Ala Thr Arg Gln Pro Ser Gly Thr Gly Pro Glu 
                165                 170                 175     


Asp Thr Glu Gly Gly Arg His Ala Pro Glu Leu Leu Lys His Gln Leu 
            180                 185                 190         


Leu Gly Asp Leu His Gln Glu Gly Pro Pro Leu Lys Gly Ala Gly Gly 
        195                 200                 205             


Lys Glu Arg Pro Gly Ser Lys Glu Glu Val Asp Glu Asp Arg Asp Val 
    210                 215                 220                 


Asp Glu Ser Ser Pro Gln Asp Ser Pro Pro Ser Lys Ala Ser Pro Ala 
225                 230                 235                 240 


Gln Asp Gly Arg Pro Pro Gln Thr Ala Ala Arg Glu Ala Thr Ser Ile 
                245                 250                 255     


Pro Gly Phe Pro Ala Glu Gly Ala Ile Pro Leu Pro Val Asp Phe Leu 
            260                 265                 270         


Ser Lys Val Ser Thr Glu Ile Pro Ala Ser Glu Pro Asp Gly Pro Ser 
        275                 280                 285             


Val Gly Arg Ala Lys Gly Gln Asp Ala Pro Leu Glu Phe Thr Phe His 
    290                 295                 300                 


Val Glu Ile Thr Pro Asn Val Gln Lys Glu Gln Ala His Ser Glu Glu 
305                 310                 315                 320 


His Leu Gly Arg Ala Ala Phe Pro Gly Ala Pro Gly Glu Gly Pro Glu 
                325                 330                 335     


Ala Arg Gly Pro Ser Leu Gly Glu Asp Thr Lys Glu Ala Asp Leu Pro 
            340                 345                 350         


Glu Pro Ser Glu Lys Gln Pro Ala Ala Ala Pro Arg Gly Lys Pro Val 
        355                 360                 365             


Ser Arg Val Pro Gln Leu Lys Ala Arg Met Val Ser Lys Ser Lys Asp 
    370                 375                 380                 


Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Thr Ser Thr Arg Ser Ser 
385                 390                 395                 400 


Ala Lys Thr Leu Lys Asn Arg Pro Cys Leu Ser Pro Lys His Pro Thr 
                405                 410                 415     


Pro Gly Ser Ser Asp Pro Leu Ile Gln Pro Ser Ser Pro Ala Val Cys 
            420                 425                 430         


Pro Glu Pro Pro Ser Ser Pro Lys Tyr Val Ser Ser Val Thr Ser Arg 
        435                 440                 445             


Thr Gly Ser Ser Gly Ala Lys Glu Met Lys Leu Lys Gly Ala Asp Gly 
    450                 455                 460                 


Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys 
465                 470                 475                 480 


Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro 
                485                 490                 495     


Lys Thr Pro Pro Ser Ser Ala Thr Lys Gln Val Gln Arg Arg Pro Pro 
            500                 505                 510         


Pro Ala Gly Pro Arg Ser Glu Arg Gly Glu Pro Pro Lys Ser Gly Asp 
        515                 520                 525             


Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg 
    530                 535                 540                 


Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys 
545                 550                 555                 560 


Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser 
                565                 570                 575     


Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys 
            580                 585                 590         


Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly 
        595                 600                 605             


Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser 
    610                 615                 620                 


Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser 
625                 630                 635                 640 


Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
                645                 650                 655     


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
            660                 665                 670         


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
        675                 680                 685             


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
    690                 695                 700                 


Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys 
705                 710                 715                 720 


Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly 
                725                 730                 735     


Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile 
            740                 745                 750         


Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser 
        755                 760                 765             


Ala Ser Leu Ala Lys Gln Gly Leu 
    770                 775     


<210>  24
<211>  381
<212>  PRT
<213>  homo sapiens

<400>  24

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala 
    130                 135                 140                 


Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro 
145                 150                 155                 160 


Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
                165                 170                 175     


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
            180                 185                 190         


Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
        195                 200                 205             


Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu 
    210                 215                 220                 


Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
225                 230                 235                 240 


Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser 
                245                 250                 255     


Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro 
            260                 265                 270         


Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
        275                 280                 285             


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
    290                 295                 300                 


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu 
305                 310                 315                 320 


Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
                325                 330                 335     


Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser 
            340                 345                 350         


Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
        355                 360                 365             


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380     


<210>  25
<211>  410
<212>  PRT
<213>  homo sapiens

<400>  25

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr 
        275                 280                 285             


Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly 
    290                 295                 300                 


Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln 
305                 310                 315                 320 


Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly 
                325                 330                 335     


Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys 
            340                 345                 350         


Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val 
        355                 360                 365             


Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly 
    370                 375                 380                 


Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu 
385                 390                 395                 400 


Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410 


<210>  26
<211>  364
<212>  PRT
<213>  homo sapiens

<400>  26

Met Val Lys Leu Phe Ile Gly Asn Leu Pro Arg Glu Ala Thr Glu Gln 
1               5                   10                  15      


Glu Ile Arg Ser Leu Phe Glu Gln Tyr Gly Lys Val Leu Glu Cys Asp 
            20                  25                  30          


Ile Ile Lys Asn Tyr Gly Phe Val His Ile Glu Asp Lys Thr Ala Ala 
        35                  40                  45              


Glu Asp Ala Ile Arg Asn Leu His His Tyr Lys Leu His Gly Val Asn 
    50                  55                  60                  


Ile Asn Val Glu Ala Ser Lys Asn Lys Ser Lys Thr Ser Thr Lys Leu 
65                  70                  75                  80  


His Val Gly Asn Ile Ser Pro Thr Cys Thr Asn Lys Glu Leu Arg Ala 
                85                  90                  95      


Lys Phe Glu Glu Tyr Gly Pro Val Ile Glu Cys Asp Ile Val Lys Asp 
            100                 105                 110         


Tyr Ala Phe Val His Met Glu Arg Ala Glu Asp Ala Val Glu Ala Ile 
        115                 120                 125             


Arg Gly Leu Asp Asn Thr Glu Phe Gln Gly Lys Arg Met His Val Gln 
    130                 135                 140                 


Leu Ser Thr Ser Arg Leu Arg Thr Ala Pro Gly Met Gly Asp Gln Ser 
145                 150                 155                 160 


Gly Cys Tyr Arg Cys Gly Lys Glu Gly His Trp Ser Lys Glu Cys Pro 
                165                 170                 175     


Ile Asp Arg Ser Gly Arg Val Ala Asp Leu Thr Glu Gln Tyr Asn Glu 
            180                 185                 190         


Gln Tyr Gly Ala Val Arg Thr Pro Tyr Thr Met Ser Tyr Gly Asp Ser 
        195                 200                 205             


Leu Tyr Tyr Asn Asn Ala Tyr Gly Ala Leu Asp Ala Tyr Tyr Lys Arg 
    210                 215                 220                 


Cys Arg Ala Ala Arg Ser Tyr Glu Ala Val Ala Ala Ala Ala Ala Ser 
225                 230                 235                 240 


Val Tyr Asn Tyr Ala Glu Gln Thr Leu Ser Gln Leu Pro Gln Val Gln 
                245                 250                 255     


Asn Thr Ala Met Ala Ser His Leu Thr Ser Thr Ser Leu Asp Pro Tyr 
            260                 265                 270         


Asp Arg His Leu Leu Pro Thr Ser Gly Ala Ala Ala Thr Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Ala Ala Val Thr Ala Ala Ser Thr Ser Tyr Tyr 
    290                 295                 300                 


Gly Arg Asp Arg Ser Pro Leu Arg Arg Ala Thr Ala Pro Val Pro Thr 
305                 310                 315                 320 


Val Gly Glu Gly Tyr Gly Tyr Gly His Glu Ser Glu Leu Ser Gln Ala 
                325                 330                 335     


Ser Ala Ala Ala Arg Asn Ser Leu Tyr Asp Met Ala Arg Tyr Glu Arg 
            340                 345                 350         


Glu Gln Tyr Ala Asp Arg Ala Arg Tyr Ser Ala Phe 
        355                 360                 


<210>  27
<211>  177
<212>  PRT
<213>  homo sapiens

<400>  27

Met Val Lys Leu Phe Ile Gly Asn Leu Pro Arg Glu Ala Thr Glu Gln 
1               5                   10                  15      


Glu Ile Arg Ser Leu Phe Glu Gln Tyr Gly Lys Val Leu Glu Cys Asp 
            20                  25                  30          


Ile Ile Lys Asn Tyr Gly Phe Val His Ile Glu Asp Lys Thr Ala Ala 
        35                  40                  45              


Glu Asp Ala Ile Arg Asn Leu His His Tyr Lys Leu His Gly Val Asn 
    50                  55                  60                  


Ile Asn Val Glu Ala Ser Lys Asn Lys Ser Lys Thr Ser Thr Lys Leu 
65                  70                  75                  80  


His Val Gly Asn Ile Ser Pro Thr Cys Thr Asn Lys Glu Leu Arg Ala 
                85                  90                  95      


Lys Phe Glu Glu Tyr Gly Pro Val Ile Glu Cys Asp Ile Val Lys Asp 
            100                 105                 110         


Tyr Ala Phe Val His Met Glu Arg Ala Glu Asp Ala Val Glu Ala Ile 
        115                 120                 125             


Arg Gly Leu Asp Asn Thr Glu Phe Gln Gly Glu Pro Pro Ser Leu Gly 
    130                 135                 140                 


Arg Gly Leu Asn Thr Arg Leu Cys Ala Glu Asn Gly Trp Ile Ser Lys 
145                 150                 155                 160 


Arg Arg Gly Leu Val Lys Ile Thr Ala Val Gly Trp Leu Val Met Lys 
                165                 170                 175     


Lys 
    


<210>  28
<211>  143
<212>  PRT
<213>  homo sapiens

<400>  28

Met Val Lys Leu Phe Ile Gly Asn Leu Pro Arg Glu Ala Thr Glu Gln 
1               5                   10                  15      


Glu Ile Arg Ser Leu Phe Glu Gln Tyr Gly Lys Val Leu Glu Cys Asp 
            20                  25                  30          


Ile Ile Lys Asn Tyr Gly Phe Val His Ile Glu Asp Lys Thr Ala Ala 
        35                  40                  45              


Glu Asp Ala Ile Arg Asn Leu His His Tyr Lys Leu His Gly Val Asn 
    50                  55                  60                  


Ile Asn Val Glu Ala Ser Lys Asn Lys Ser Lys Thr Ser Thr Lys Leu 
65                  70                  75                  80  


His Val Gly Asn Ile Ser Pro Thr Cys Thr Asn Lys Glu Leu Arg Ala 
                85                  90                  95      


Lys Phe Glu Glu Tyr Gly Pro Val Ile Glu Cys Asp Ile Val Lys Asp 
            100                 105                 110         


Tyr Ala Phe Val His Met Glu Arg Ala Glu Asp Ala Val Glu Ala Ile 
        115                 120                 125             


Arg Gly Leu Asp Asn Thr Glu Phe Gln Gly Gly Met Cys Val Gly 
    130                 135                 140             


<210>  29
<211>  173
<212>  PRT
<213>  homo sapiens

<400>  29

Met Val Lys Leu Phe Ile Gly Asn Leu Pro Arg Glu Ala Thr Glu Gln 
1               5                   10                  15      


Glu Ile Arg Ser Leu Phe Glu Gln Tyr Gly Lys Val Leu Glu Cys Asp 
            20                  25                  30          


Ile Ile Lys Asn Tyr Gly Phe Val His Ile Glu Asp Lys Thr Ala Ala 
        35                  40                  45              


Glu Asp Ala Ile Arg Asn Leu His His Tyr Lys Leu His Gly Val Asn 
    50                  55                  60                  


Ile Asn Val Glu Ala Ser Lys Asn Lys Ser Lys Thr Ser Thr Lys Leu 
65                  70                  75                  80  


His Val Gly Asn Ile Ser Pro Thr Cys Thr Asn Lys Glu Leu Arg Ala 
                85                  90                  95      


Lys Phe Glu Glu Tyr Gly Pro Val Ile Glu Cys Asp Ile Val Lys Asp 
            100                 105                 110         


Tyr Ala Phe Val His Met Glu Arg Ala Glu Asp Ala Val Glu Ala Ile 
        115                 120                 125             


Arg Gly Leu Asp Asn Thr Glu Phe Gln Gly Lys Ile Thr Pro Val Thr 
    130                 135                 140                 


Glu Gly Tyr Cys Cys Cys Asn Lys Gly His Thr Tyr Ile Phe Lys Asn 
145                 150                 155                 160 


Cys Asn Leu Ile Leu Glu Ser Arg Lys Ser Arg Arg Cys 
                165                 170             


<210>  30
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  30

Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys 
1               5                   10      


