                               SEQUENCE LISTING

<110> FLAGSHIP PIONEERING INNOVATIONS V, INC.
 
<120> METHODS OF MODULATING RNA

<130> O2057-7022WO

<140> PCT/US2019/063798
<141> 2019-11-27

<150> 62/780,442
<151> 2018-12-17

<150> 62/778,361
<151> 2018-12-12

<150> 62/772,907
<151> 2018-11-29

<160> 103   

<170> PatentIn version 3.5

<210> 1
<211> 349
<212> PRT
<213> Homo sapiens

<400> 1
Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
        115                 120                 125             


Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn 
    130                 135                 140                 


His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln 
145                 150                 155                 160 


Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His 
                165                 170                 175     


Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro 
            180                 185                 190         


Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln 
        195                 200                 205             


Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu 
    210                 215                 220                 


His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly 
225                 230                 235                 240 


Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
                245                 250                 255     


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            260                 265                 270         


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met 
        275                 280                 285             


Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val 
    290                 295                 300                 


Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His 
305                 310                 315                 320 


Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys 
                325                 330                 335     


Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 


<210> 2
<211> 701
<212> PRT
<213> Homo sapiens

<400> 2
Leu Ser Asn Gly Gly Gly Gly Gly Pro Gly Arg Lys Arg Pro Leu Glu 
1               5                   10                  15      


Glu Gly Ser Asn Gly His Ser Lys Tyr Arg Leu Lys Lys Arg Arg Lys 
            20                  25                  30          


Thr Pro Gly Pro Val Leu Pro Lys Asn Ala Leu Met Gln Leu Asn Glu 
        35                  40                  45              


Ile Lys Pro Gly Leu Gln Tyr Thr Leu Leu Ser Gln Thr Gly Pro Val 
    50                  55                  60                  


His Ala Pro Leu Phe Val Met Ser Val Glu Val Asn Gly Gln Val Phe 
65                  70                  75                  80  


Glu Gly Ser Gly Pro Thr Lys Lys Lys Ala Lys Leu His Ala Ala Glu 
                85                  90                  95      


Lys Ala Leu Arg Ser Phe Val Gln Phe Pro Asn Ala Ser Glu Ala His 
            100                 105                 110         


Leu Ala Met Gly Arg Thr Leu Ser Val Asn Thr Asp Phe Thr Ser Asp 
        115                 120                 125             


Gln Ala Asp Phe Pro Asp Thr Leu Phe Asn Gly Phe Glu Thr Pro Asp 
    130                 135                 140                 


Lys Ala Glu Pro Pro Phe Tyr Val Gly Ser Asn Gly Asp Asp Ser Phe 
145                 150                 155                 160 


Ser Ser Ser Gly Asp Leu Ser Leu Ser Ala Ser Pro Val Pro Ala Ser 
                165                 170                 175     


Leu Ala Gln Pro Pro Leu Pro Val Leu Pro Pro Phe Pro Pro Pro Ser 
            180                 185                 190         


Gly Lys Asn Pro Val Met Ile Leu Asn Glu Leu Arg Pro Gly Leu Lys 
        195                 200                 205             


Tyr Asp Phe Leu Ser Glu Ser Gly Glu Ser His Ala Lys Ser Phe Val 
    210                 215                 220                 


Met Ser Val Val Val Asp Gly Gln Phe Phe Glu Gly Ser Gly Arg Asn 
225                 230                 235                 240 


Lys Lys Leu Ala Lys Ala Arg Ala Ala Gln Ser Ala Leu Ala Ala Ile 
                245                 250                 255     


Phe Asn Leu His Leu Asp Gln Thr Pro Ser Arg Gln Pro Ile Pro Ser 
            260                 265                 270         


Glu Gly Leu Gln Leu His Leu Pro Gln Val Leu Ala Asp Ala Val Ser 
        275                 280                 285             


Arg Leu Val Leu Gly Lys Phe Gly Asp Leu Thr Asp Asn Phe Ser Ser 
    290                 295                 300                 


Pro His Ala Arg Arg Lys Val Leu Ala Gly Val Val Met Thr Thr Gly 
305                 310                 315                 320 


Thr Asp Val Lys Asp Ala Lys Val Ile Ser Val Ser Thr Gly Thr Lys 
                325                 330                 335     


Cys Ile Asn Gly Glu Tyr Met Ser Asp Arg Gly Leu Ala Leu Asn Asp 
            340                 345                 350         


Cys His Ala Glu Ile Ile Ser Arg Arg Ser Leu Leu Arg Phe Leu Tyr 
        355                 360                 365             


Thr Gln Leu Glu Leu Tyr Leu Asn Asn Lys Asp Asp Gln Lys Arg Ser 
    370                 375                 380                 


Ile Phe Gln Lys Ser Glu Arg Gly Gly Phe Arg Leu Lys Glu Asn Val 
385                 390                 395                 400 


Gln Phe His Leu Tyr Ile Ser Thr Ser Pro Cys Gly Asp Ala Arg Ile 
                405                 410                 415     


Phe Ser Pro His Glu Pro Ile Leu Glu Gly Ser Arg Ser Tyr Thr Gln 
            420                 425                 430         


Ala Gly Val Gln Trp Cys Asn His Gly Ser Leu Gln Pro Arg Pro Pro 
        435                 440                 445             


Gly Leu Leu Ser Asp Pro Ser Thr Ser Thr Phe Gln Gly Ala Gly Thr 
    450                 455                 460                 


Thr Glu Pro Ala Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu 
465                 470                 475                 480 


Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val Arg Ser Asn 
                485                 490                 495     


Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu 
            500                 505                 510         


Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile 
        515                 520                 525             


Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser 
    530                 535                 540                 


Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met 
545                 550                 555                 560 


Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu 
                565                 570                 575     


Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro 
            580                 585                 590         


Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala 
        595                 600                 605             


Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg Ala 
    610                 615                 620                 


Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His 
625                 630                 635                 640 


Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn 
                645                 650                 655     


Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys 
            660                 665                 670         


Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val 
        675                 680                 685             


Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro 
    690                 695                 700     


<210> 3
<211> 883
<212> PRT
<213> Homo sapiens

<400> 3
Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn 
    50                  55                  60                  


Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln 
65                  70                  75                  80  


Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser 
                85                  90                  95      


Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile 
            100                 105                 110         


Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met 
        115                 120                 125             


Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln 
    130                 135                 140                 


Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr 
145                 150                 155                 160 


Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr 
                165                 170                 175     


Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr 
            180                 185                 190         


Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile 
        195                 200                 205             


Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile 
    210                 215                 220                 


Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu 
225                 230                 235                 240 


Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn 
                245                 250                 255     


Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys 
            260                 265                 270         


Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala 
        275                 280                 285             


His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val 
    290                 295                 300                 


Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu 
305                 310                 315                 320 


Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val 
                325                 330                 335     


Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln 
            340                 345                 350         


Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg 
        355                 360                 365             


Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg 
    370                 375                 380                 


Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr 
385                 390                 395                 400 


Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val 
                405                 410                 415     


Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn 
            420                 425                 430         


His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp 
        435                 440                 445             


Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr 
    450                 455                 460                 


Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile 
465                 470                 475                 480 


Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala 
                485                 490                 495     


Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro 
        515                 520                 525             


Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr 
    530                 535                 540                 


Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val 
545                 550                 555                 560 


Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu 
                565                 570                 575     


Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe 
            580                 585                 590         


Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln 
        595                 600                 605             


Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly 
    610                 615                 620                 


Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
625                 630                 635                 640 


Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser 
                645                 650                 655     


Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp 
            660                 665                 670         


Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe 
        675                 680                 685             


Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val 
    690                 695                 700                 


Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys 
705                 710                 715                 720 


Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg 
                725                 730                 735     


Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly 
            740                 745                 750         


Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Asn Ala Val Asn 
        755                 760                 765             


Leu Ala Val Leu Lys Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys 
    770                 775                 780                 


Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp 
785                 790                 795                 800 


Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val 
                805                 810                 815     


Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu 
            820                 825                 830         


Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val 
        835                 840                 845             


Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln 
    850                 855                 860                 


Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser 
865                 870                 875                 880 


Val Lys Ile 
            


<210> 4
<211> 2145
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
augggcagga gcaggcuuuu ggaagauuuu cgaaacaacc gcuaccccaa uuuacaacug       60

cgggagauug cuggacauau aauggaauuu ucccaagacc agcauggguc cagauucauu      120

cagcugaaac uggagcgugc cacaccagcu gagcgccagc uugucuucaa ugaaauccuc      180

caggcugccu accaacucau gguggaugug uuugguaauu acgucauuca gaaguucuuu      240

gaauuuggca gucuugaaca gaagcuggcu uuggcagaac ggauucgagg ccacguccug      300

ucauuggcac uacagaugua uggcugccgu guuauccaga aagcucuuga guuuauuccu      360

ucagaccagc agaaugagau gguucgggaa cuagauggcc augucuugaa gugugugaaa      420

gaucagaaug gcaaucacgu gguucagaaa ugcauugaau guguacagcc ccagucuuug      480

caauuuauca ucgaugcguu uaagggacag guauuugccu uauccacaca uccuuauggc      540

ugccgaguga uucagagaau ccuggagcac ugucucccug accagacacu cccuauuuua      600

gaggagcuuc accagcacac agagcagcuu guacaggauc aauauggaaa uuauguaauc      660

caacauguac uggagcacgg ucguccugag gauaaaagca aaauuguagc agaaauccga      720

ggcaauguac uuguauugag ucagcacaaa uuugcaagca auguugugga gaaguguguu      780

acucacgccu cacguacgga gcgcgcugug cucaucgaug aggugugcac caugaacgac      840

gguccccaca gugccuuaua caccaugaug aaggaccagu augccaacua cgugguccag      900

aagaugauug acguggcgga gccaggccag cggaagaucg ucaugcauaa gauccggccc      960

cacaucgcaa cucuucguaa guacaccuau ggcaagcaca uucuggccaa gcuggagaag     1020

uacuacauga agaacggugu ugacuuaggg ggagguggcg gaucgggagg uggcggaucg     1080

ggagguggcg gaucgggcag gagcaggcuu uuggaagauu uucgaaacaa ccgcuacccc     1140

aauuuacaac ugcgggagau ugcuggacau auaauggaau uuucccaaga ccagcauggg     1200

uccagauuca uucagcugaa acuggagcgu gccacaccag cugagcgcca gcuugucuuc     1260

aaugaaaucc uccaggcugc cuaccaacuc augguggaug uguuugguaa uuacgucauu     1320

cagaaguucu uugaauuugg cagucuugaa cagaagcugg cuuuggcaga acggauucga     1380

ggccacgucc ugucauuggc acuacagaug uauggcugcc guguuaucca gaaagcucuu     1440

gaguuuauuc cuucagacca gcagaaugag augguucggg aacuagaugg ccaugucuug     1500

aaguguguga aagaucagaa uggcaaucac gugguucaga aaugcauuga auguguacag     1560

ccccagucuu ugcaauuuau caucgaugcg uuuaagggac agguauuugc cuuauccaca     1620

cauccuuaug gcugccgagu gauucagaga auccuggagc acugucuccc ugaccagaca     1680

cucccuauuu uagaggagcu ucaccagcac acagagcagc uuguacagga ucaauaugga     1740

aauuauguaa uccaacaugu acuggagcac ggucguccug aggauaaaag caaaauugua     1800

gcagaaaucc gaggcaaugu acuuguauug agucagcaca aauuugcaag caauguugug     1860

gagaagugug uuacucacgc cucacguacg gagcgcgcug ugcucaucga ugaggugugc     1920

accaugaacg acggucccca cagugccuua uacaccauga ugaaggacca guaugccaac     1980

uacguggucc agaagaugau ugacguggcg gagccaggcc agcggaagau cgucaugcau     2040

aagauccggc cccacaucgc aacucuucgu aaguacaccu auggcaagca cauucuggcc     2100

aagcuggaga aguacuacau gaagaacggu guugacuuag gguga                     2145


<210> 5
<211> 1215
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
augcuccacc ucgaccaaac acccagcaga cagccuaucc cuuccgaagg acugcagcug       60

cauuuaccgc agguuuuagc ugacgcuguc ucacgccugg uccuggguaa guuuggugau      120

cugaccgaca acuucuccuc cccucacgcu cgcagaaaag ugcuggcugg agucgucaug      180

acaacaggca cagauguuaa agaugccaag gugauaagug uuucuacagg aggcaaaugu      240

auuaauggug aauacaugag ugaucguggc cuugcauuaa augacugcca ugcagaaaua      300

auaucucgga gauccuugcu cagauuucuu uauacacaac uugagcuuua cuuaaauaac      360

aaagaugauc aaaaaagauc caucuuucag aaaucagagc gagggggguu uaggcugaag      420

gagaaugucc aguuucaucu guacaucagc accucucccu guggagaugc cagaaucuuc      480

ucaccacaug agccaauccu ggaagaacca gcagauagac acccaaaucg uaaagcaaga      540

ggacagcuac ggaccaaaau agagucuggu caggggacga uuccagugcg cuccaaugcg      600

agcauccaaa cgugggacgg ggugcugcaa ggggagcggc ugcucaccau guccugcagu      660

gacaagauug cacgcuggaa cguggugggc auccagggau cacugcucag cauuuucgug      720

gagcccauuu acuucucgag caucauccug ggcagccuuu accacgggga ccaccuuucc      780

agggccaugu accagcggau cuccaacaua gaggaccugc caccucucua cacccucaac      840

aagccuuugc ucaguggcau cagcaaugca gaagcacggc agccagggaa ggcccccaac      900

uucaguguca acuggacggu aggcgacucc gcuauugagg ucaucaacgc cacgacuggg      960

aaggaugagc ugggccgcgc gucccgccug uguaagcacg cguuguacug ucgcuggaug     1020

cgugugcacg gcaagguucc cucccacuua cuacgcucca agauuaccaa gcccaacgug     1080

uaccaugagu ccaagcuggc ggcaaaggag uaccaggccg ccaaggcgcg ucuguucaca     1140

gccuucauca aggcggggcu gggggccugg guggagaagc ccaccgagca ggaccaguuc     1200

ucacucacgc cuuga                                                      1215


<210> 6
<211> 3573
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
auggacuaua aggaccacga cggagacuac aaggaucaug auauugauua caaagacgau       60

gacgauaaga uggccccaaa gaagaagcgg aaggucggua uccacggagu cccagcagcc      120

cuccaccucg accaaacacc cagcagacag ccuaucccuu ccgaaggacu gcagcugcau      180

uuaccgcagg uuuuagcuga cgcugucuca cgccuggucc uggguaaguu uggugaucug      240

accgacaacu ucuccucccc ucacgcucgc agaaaagugc uggcuggagu cgucaugaca      300

acaggcacag auguuaaaga ugccaaggug auaaguguuu cuacaggagg caaauguauu      360

aauggugaau acaugaguga ucguggccuu gcauuaaaug acugccaugc agaaauaaua      420

ucucggagau ccuugcucag auuucuuuau acacaacuug agcuuuacuu aaauaacaaa      480

gaugaucaaa aaagauccau cuuucagaaa ucagagcgag ggggguuuag gcugaaggag      540

aauguccagu uucaucugua caucagcacc ucucccugug gagaugccag aaucuucuca      600

ccacaugagc caauccugga agaaccagca gauagacacc caaaucguaa agcaagagga      660

cagcuacgga ccaaaauaga gucuggucag gggacgauuc cagugcgcuc caaugcgagc      720

auccaaacgu gggacggggu gcugcaaggg gagcggcugc ucaccauguc cugcagugac      780

aagauugcac gcuggaacgu ggugggcauc cagggaucac ugcucagcau uuucguggag      840

cccauuuacu ucucgagcau cauccugggc agccuuuacc acggggacca ccuuuccagg      900

gccauguacc agcggaucuc caacauagag gaccugccac cucucuacac ccucaacaag      960

ccuuugcuca guggcaucag caaugcagaa gcacggcagc cagggaaggc ccccaacuuc     1020

agugucaacu ggacgguagg cgacuccgcu auugagguca ucaacgccac gacugggaag     1080

gaugagcugg gccgcgcguc ccgccugugu aagcacgcgu uguacugucg cuggaugcgu     1140

gugcacggca agguucccuc ccacuuacua cgcuccaaga uuaccaagcc caacguguac     1200

caugagucca agcuggcggc aaaggaguac caggccgcca aggcgcgucu guucacagcc     1260

uucaucaagg cggggcuggg ggccugggug gagaagccca ccgagcagga ccaguucuca     1320

cucacgccug gagguggcgg aucgggaggu ggcggaucgg gagguggcgg aucgggcagg     1380

agcaggcuuu uggaagauuu ucgaaacaac cgcuacccca auuuacaacu gcgggagauu     1440

gcuggacaua uaauggaauu uucccaagac cagcaugggu ccagauucau ucagcugaaa     1500

cuggagcgug ccacaccagc ugagcgccag cuugucuuca augaaauccu ccaggcugcc     1560

uaccaacuca ugguggaugu guuugguaau uacgucauuc agaaguucuu ugaauuuggc     1620

agucuugaac agaagcuggc uuuggcagaa cggauucgag gccacguccu gucauuggca     1680

cuacagaugu auggcugccg uguuauccag aaagcucuug aguuuauucc uucagaccag     1740

cagaaugaga ugguucggga acuagauggc caugucuuga agugugugaa agaucagaau     1800

ggcaaucacg ugguucagaa augcauugaa uguguacagc cccagucuuu gcaauuuauc     1860

aucgaugcgu uuaagggaca gguauuugcc uuauccacac auccuuaugg cugccgagug     1920

auucagagaa uccuggagca cugucucccu gaccagacac ucccuauuuu agaggagcuu     1980

caccagcaca cagagcagcu uguacaggau caauauggaa auuauguaau ccaacaugua     2040

cuggagcacg gucguccuga ggauaaaagc aaaauuguag cagaaauccg aggcaaugua     2100

cuuguauuga gucagcacaa auuugcaagc aauguugugg agaagugugu uacucacgcc     2160

ucacguacgg agcgcgcugu gcucaucgau gaggugugca ccaugaacga cgguccccac     2220

agugccuuau acaccaugau gaaggaccag uaugccaacu acguggucca gaagaugauu     2280

gacguggcgg agccaggcca gcggaagauc gucaugcaua agauccggcc ccacaucgca     2340

acucuucgua aguacaccua uggcaagcac auucuggcca agcuggagaa guacuacaug     2400

aagaacggug uugacuuagg gggagguggc ggaucgggag guggcggauc gggagguggc     2460

ggaucgggca ggagcaggcu uuuggaagau uuucgaaaca accgcuaccc caauuuacaa     2520

cugcgggaga uugcuggaca uauaauggaa uuuucccaag accagcaugg guccagauuc     2580

auucagcuga aacuggagcg ugccacacca gcugagcgcc agcuugucuu caaugaaauc     2640

cuccaggcug ccuaccaacu caugguggau guguuuggua auuacgucau ucagaaguuc     2700

uuugaauuug gcagucuuga acagaagcug gcuuuggcag aacggauucg aggccacguc     2760

cugucauugg cacuacagau guauggcugc cguguuaucc agaaagcucu ugaguuuauu     2820

ccuucagacc agcagaauga gaugguucgg gaacuagaug gccaugucuu gaagugugug     2880

aaagaucaga auggcaauca cgugguucag aaaugcauug aauguguaca gccccagucu     2940

uugcaauuua ucaucgaugc guuuaaggga cagguauuug ccuuauccac acauccuuau     3000

ggcugccgag ugauucagag aauccuggag cacugucucc cugaccagac acucccuauu     3060

uuagaggagc uucaccagca cacagagcag cuuguacagg aucaauaugg aaauuaugua     3120

auccaacaug uacuggagca cggucguccu gaggauaaaa gcaaaauugu agcagaaauc     3180

cgaggcaaug uacuuguauu gagucagcac aaauuugcaa gcaauguugu ggagaagugu     3240

guuacucacg ccucacguac ggagcgcgcu gugcucaucg augaggugug caccaugaac     3300

gacggucccc acagugccuu auacaccaug augaaggacc aguaugccaa cuacgugguc     3360

cagaagauga uugacguggc ggagccaggc cagcggaaga ucgucaugca uaagauccgg     3420

ccccacaucg caacucuucg uaaguacacc uauggcaagc acauucuggc caagcuggag     3480

aaguacuaca ugaagaacgg uguugacuua gggagcggcg gcaagcggcc cgccgccacc     3540

aagaaggccg gccaggccaa gaagaagaag uga                                  3573


<210> 7
<211> 2145
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 7
augggccgca gccgccuuuu ggaagauuuu cgaaacaacc gguaccccaa uuuacaacug       60

cgggagauug ccggacauau aauggaauuu ucccaagacc agcauggguc cagauucauu      120

cgccugaaac uggagcgugc cacaccagcu gagcgccagc uugucuuuaa ugaaauccuc      180

caggcugccu accaacucau gguggaugug uuugguaguu acgucauuga gaaguucuuu      240

gaauuuggca gucuugaaca gaagcuggcu uuggcagaac ggauucgagg ucacguccug      300

ucauuggcac uacagaugua uggcugccgu guuauccaga aagcucuuga guuuauuccu      360

ucagaccagc agaaugagau gguucgggaa cuagauggcc augucuugaa gugugugaaa      420

gaucagaaug gcugucacgu gguucagaaa ugcauugaau guguacagcc ccagucuuug      480

caauuuauca ucgaugcguu uaagggccag guauuugccu uauccacaca uccuuauggc      540

ucccgaguga uugagagaau ccuggagcac ugucucccug accagacacu cccuauuuua      600

gaggagcuuc accagcacac agagcagcuu guacaggauc aauauggaug uuauguaauc      660

caacauguac uggagcacgg ucguccugag gauaaaagca aaauuguagc agaaauccga      720

ggcaauguac uuguauugag ucagcacaaa uuugcaugca auguugugca gaaguguguu      780

acucacgccu cacguacgga gcgcgcugug cucaucgaug aggugugcac caugaacgac      840

gguccccaca gugccuuaua caccaugaug aaggaccagu augccagcua cgugguccgc      900

aagaugauug acguggcgga gccaggccag cggaagaucg ucaugcauaa gauccgaccc      960

cacaucgcaa cucuucguaa guacaccuau ggcaagcaca uucuggccaa gcuggagaag     1020

uacuacauga agaacggugu ugacuuaggg ggagguggcg gaucgggagg uggcggaucg     1080

ggagguggcg gaucgggccg cagccgccuu uuggaagauu uucgaaacaa ccgguacccc     1140

aauuuacaac ugcgggagau ugccggacau auaauggaau uuucccaaga ccagcauggg     1200

aacagauuca uucagcugaa acuggagcgu gccacaccag cugagcgcca gcuugucuuu     1260

aaugaaaucc uccaggcugc cuaccaacuc augguggaug uguuugguug uuacgucauu     1320

cagaaguucu uugaauuugg cagucuugaa cagaagcugg cuuuggcaga acggauucga     1380

ggucacgucc ugucauuggc acuacagaug uauggcuccc guguuaucga gaaagcucuu     1440

gaguuuauuc cuucagacca gcagaaugag augguucggg aacuagaugg ccaugucuug     1500

aaguguguga aagaucagaa uggcaaucac gugguucaga aaugcauuga auguguacag     1560

ccccagucuu ugcaauuuau caucgaugcg uuuaagggac agguauuugc cuuauccaca     1620

cauccuuaug gcugccgagu gauucagaga auccuggagc acugucuccc ugaccagaca     1680

cucccuauuu uagaggagcu ucaccagcac acagagcagc uuguacagga ucaauaugga     1740

aguuauguaa uccgccaugu acuggagcac ggucguccug aggauaaaag caaaauugua     1800

gcagaaaucc gaggcaaugu acuuguauug agucagcaca aauuugcaaa caauguugug     1860

cagaagugug uuacucacgc cucacguacg gagcgcgcug ugcucaucga ugaggugugc     1920

accaugaacg acggucccca cagugccuua uacaccauga ugaaggacca guaugccugc     1980

uacguggucc agaagaugau ugacguggcg gagccaggcc agcggaagau cgucaugcau     2040

aagauccgac cccacaucgc aacucuucgu aaguacaccu auggcaagca cauucuggcc     2100

aagcuggaga aguacuacau gaagaacggu guugacuuag gguga                     2145


<210> 8
<211> 3573
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 8
auggacuaua aggaccacga cggagacuac aaggaucaug auauugauua caaagacgau       60

gacgauaaga uggccccaaa gaagaagcgg aaggucggua uccacggagu cccagcagcc      120

cuccaccucg accaaacacc cagcagacag ccuaucccuu ccgaaggacu gcagcugcau      180

uuaccgcagg uuuuagcuga cgcugucuca cgccuggucc uggguaaguu uggugaucug      240

accgacaacu ucuccucccc ucacgcucgc agaaaagugc uggcuggagu cgucaugaca      300

acaggcacag auguuaaaga ugccaaggug auaaguguuu cuacaggagg caaauguauu      360

aauggugaau acaugaguga ucguggccuu gcauuaaaug acugccaugc agaaauaaua      420

ucucggagau ccuugcucag auuucuuuau acacaacuug agcuuuacuu aaauaacaaa      480

gaugaucaaa aaagauccau cuuucagaaa ucagagcgag ggggguuuag gcugaaggag      540

aauguccagu uucaucugua caucagcacc ucucccugug gagaugccag aaucuucuca      600

ccacaugagc caauccugga agaaccagca gauagacacc caaaucguaa agcaagagga      660

cagcuacgga ccaaaauaga gucuggucag gggacgauuc cagugcgcuc caaugcgagc      720

auccaaacgu gggacggggu gcugcaaggg gagcggcugc ucaccauguc cugcagugac      780

aagauugcac gcuggaacgu ggugggcauc cagggaucac ugcucagcau uuucguggag      840

cccauuuacu ucucgagcau cauccugggc agccuuuacc acggggacca ccuuuccagg      900

gccauguacc agcggaucuc caacauagag gaccugccac cucucuacac ccucaacaag      960

ccuuugcuca guggcaucag caaugcagaa gcacggcagc cagggaaggc ccccaacuuc     1020

agugucaacu ggacgguagg cgacuccgcu auugagguca ucaacgccac gacugggaag     1080

gaugagcugg gccgcgcguc ccgccugugu aagcacgcgu uguacugucg cuggaugcgu     1140

gugcacggca agguucccuc ccacuuacua cgcuccaaga uuaccaagcc caacguguac     1200

caugagucca agcuggcggc aaaggaguac caggccgcca aggcgcgucu guucacagcc     1260

uucaucaagg cggggcuggg ggccugggug gagaagccca ccgagcagga ccaguucuca     1320

cucacgccug gagguggcgg aucgggaggu ggcggaucgg gagguggcgg aucgggccgc     1380

agccgccuuu uggaagauuu ucgaaacaac cgguacccca auuuacaacu gcgggagauu     1440

gccggacaua uaauggaauu uucccaagac cagcaugggu ccagauucau ucgccugaaa     1500

cuggagcgug ccacaccagc ugagcgccag cuugucuuua augaaauccu ccaggcugcc     1560

uaccaacuca ugguggaugu guuugguagu uacgucauug agaaguucuu ugaauuuggc     1620

agucuugaac agaagcuggc uuuggcagaa cggauucgag gucacguccu gucauuggca     1680

cuacagaugu auggcugccg uguuauccag aaagcucuug aguuuauucc uucagaccag     1740

cagaaugaga ugguucggga acuagauggc caugucuuga agugugugaa agaucagaau     1800

ggcugucacg ugguucagaa augcauugaa uguguacagc cccagucuuu gcaauuuauc     1860

aucgaugcgu uuaagggcca gguauuugcc uuauccacac auccuuaugg cucccgagug     1920

auugagagaa uccuggagca cugucucccu gaccagacac ucccuauuuu agaggagcuu     1980

caccagcaca cagagcagcu uguacaggau caauauggau guuauguaau ccaacaugua     2040

cuggagcacg gucguccuga ggauaaaagc aaaauuguag cagaaauccg aggcaaugua     2100

cuuguauuga gucagcacaa auuugcaugc aauguugugc agaagugugu uacucacgcc     2160

ucacguacgg agcgcgcugu gcucaucgau gaggugugca ccaugaacga cgguccccac     2220

agugccuuau acaccaugau gaaggaccag uaugccagcu acgugguccg caagaugauu     2280

gacguggcgg agccaggcca gcggaagauc gucaugcaua agauccgacc ccacaucgca     2340

acucuucgua aguacaccua uggcaagcac auucuggcca agcuggagaa guacuacaug     2400

aagaacggug uugacuuagg gggagguggc ggaucgggag guggcggauc gggagguggc     2460

ggaucgggcc gcagccgccu uuuggaagau uuucgaaaca accgguaccc caauuuacaa     2520

cugcgggaga uugccggaca uauaauggaa uuuucccaag accagcaugg gaacagauuc     2580

auucagcuga aacuggagcg ugccacacca gcugagcgcc agcuugucuu uaaugaaauc     2640

cuccaggcug ccuaccaacu caugguggau guguuugguu guuacgucau ucagaaguuc     2700

uuugaauuug gcagucuuga acagaagcug gcuuuggcag aacggauucg aggucacguc     2760

cugucauugg cacuacagau guauggcucc cguguuaucg agaaagcucu ugaguuuauu     2820

ccuucagacc agcagaauga gaugguucgg gaacuagaug gccaugucuu gaagugugug     2880

aaagaucaga auggcaauca cgugguucag aaaugcauug aauguguaca gccccagucu     2940

uugcaauuua ucaucgaugc guuuaaggga cagguauuug ccuuauccac acauccuuau     3000

ggcugccgag ugauucagag aauccuggag cacugucucc cugaccagac acucccuauu     3060

uuagaggagc uucaccagca cacagagcag cuuguacagg aucaauaugg aaguuaugua     3120

auccgccaug uacuggagca cggucguccu gaggauaaaa gcaaaauugu agcagaaauc     3180

cgaggcaaug uacuuguauu gagucagcac aaauuugcaa acaauguugu gcagaagugu     3240

guuacucacg ccucacguac ggagcgcgcu gugcucaucg augaggugug caccaugaac     3300

gacggucccc acagugccuu auacaccaug augaaggacc aguaugccug cuacgugguc     3360

cagaagauga uugacguggc ggagccaggc cagcggaaga ucgucaugca uaagauccga     3420

ccccacaucg caacucuucg uaaguacacc uauggcaagc acauucuggc caagcuggag     3480

aaguacuaca ugaagaacgg uguugacuua gggagcggcg gcaagcggcc cgccgccacc     3540

aagaaggccg gccaggccaa gaagaagaag uga                                  3573


<210> 9
<211> 2145
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 9
augggccgca gccgccuuuu ggaagauuuu cgaaacaacc gguaccccaa uuuacaacug       60

cgggagauug ccggacauau aauggaauuu ucccaagacc agcauggguc cagauucauu      120

cagcugaaac uggagcgugc cacaccagcu gagcgccagc uugucuuuaa ugaaauccuc      180

caggcugccu accaacucau gguggaugug uuugguuguu acgucauuca gaaguucuuu      240

gaauuuggca gucuugaaca gaagcuggcu uuggcagaac ggauucgagg ucacguccug      300

ucauuggcac uacagaugua uggcucccgu guuauccgca aagcucuuga guuuauuccu      360

ucagaccagc agaaugagau gguucgggaa cuagauggcc augucuugaa gugugugaaa      420

gaucagaaug gcugucacgu gguucagaaa ugcauugaau guguacagcc ccagucuuug      480

caauuuauca ucgaugcguu uaagggccag guauuugccu uauccacaca uccuuauggc      540

ucccgaguga uugagagaau ccuggagcac ugucucccug accagacacu cccuauuuua      600

gaggagcuuc accagcacac agagcagcuu guacaggauc aauauggaug uuauguaauc      660

caacauguac uggagcacgg ucguccugag gauaaaagca aaauuguagc agaaauccga      720

ggcaauguac uuguauugag ucagcacaaa uuugcaaaca auguugugca gaaguguguu      780

acucacgccu cacguacgga gcgcgcugug cucaucgaug aggugugcac caugaacgac      840

gguccccaca gugccuuaua caccaugaug aaggaccagu augccaacua cgugguccag      900

aagaugauug acguggcgga gccaggccag cggaagaucg ucaugcauaa gauccgaccc      960

cacaucgcaa cucuucguaa guacaccuau ggcaagcaca uucuggccaa gcuggagaag     1020

uacuacauga agaacggugu ugacuuaggg ggagguggcg gaucgggagg uggcggaucg     1080

ggagguggcg gaucgggccg cagccgccuu uuggaagauu uucgaaacaa ccgguacccc     1140

aauuuacaac ugcgggagau ugccggacau auaauggaau uuucccaaga ccagcauggg     1200

aacagauuca uucagcugaa acuggagcgu gccacaccag cugagcgcca gcuugucuuu     1260

aaugaaaucc uccaggcugc cuaccaacuc augguggaug uguuugguaa uuacgucauu     1320

cagaaguucu uugaauuugg cagucuugaa cagaagcugg cuuuggcaga acggauucga     1380

ggucacgucc ugucauuggc acuacagaug uauggcuccc guguuaucga gaaagcucuu     1440

gaguuuauuc cuucagacca gcagaaugag augguucggg aacuagaugg ccaugucuug     1500

aaguguguga aagaucagaa uggcagucac gugguugaga aaugcauuga auguguacag     1560

ccccagucuu ugcaauuuau caucgaugcg uuuaagggac agguauuugc cuuauccaca     1620

cauccuuaug gcucccgagu gauugagaga auccuggagc acugucuccc ugaccagaca     1680

cucccuauuu uagaggagcu ucaccagcac acagagcagc uuguacagga ucaauaugga     1740

uguuauguaa uccaacaugu acuggagcac ggucguccug aggauaaaag caaaauugua     1800

gcagaaaucc gaggcaaugu acuuguauug agucagcaca aauuugcaag cuauguugug     1860

cgcaagugug uuacucacgc cucacguacg gagcgcgcug ugcucaucga ugaggugugc     1920

accaugaacg acggucccca cagugccuua uacaccauga ugaaggacca guaugccugc     1980

uacguggucc agaagaugau ugacguggcg gagccaggcc agcggaagau cgucaugcau     2040

aagauccgac cccacaucgc aacucuucgu aaguacaccu auggcaagca cauucuggcc     2100

aagcuggaga aguacuacau gaagaacggu guugacuuag gguga                     2145


<210> 10
<211> 3573
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
auggacuaua aggaccacga cggagacuac aaggaucaug auauugauua caaagacgau       60

gacgauaaga uggccccaaa gaagaagcgg aaggucggua uccacggagu cccagcagcc      120

cuccaccucg accaaacacc cagcagacag ccuaucccuu ccgaaggacu gcagcugcau      180

uuaccgcagg uuuuagcuga cgcugucuca cgccuggucc uggguaaguu uggugaucug      240

accgacaacu ucuccucccc ucacgcucgc agaaaagugc uggcuggagu cgucaugaca      300

acaggcacag auguuaaaga ugccaaggug auaaguguuu cuacaggagg caaauguauu      360

aauggugaau acaugaguga ucguggccuu gcauuaaaug acugccaugc agaaauaaua      420

ucucggagau ccuugcucag auuucuuuau acacaacuug agcuuuacuu aaauaacaaa      480

gaugaucaaa aaagauccau cuuucagaaa ucagagcgag ggggguuuag gcugaaggag      540

aauguccagu uucaucugua caucagcacc ucucccugug gagaugccag aaucuucuca      600

ccacaugagc caauccugga agaaccagca gauagacacc caaaucguaa agcaagagga      660

cagcuacgga ccaaaauaga gucuggucag gggacgauuc cagugcgcuc caaugcgagc      720

auccaaacgu gggacggggu gcugcaaggg gagcggcugc ucaccauguc cugcagugac      780

aagauugcac gcuggaacgu ggugggcauc cagggaucac ugcucagcau uuucguggag      840

cccauuuacu ucucgagcau cauccugggc agccuuuacc acggggacca ccuuuccagg      900

gccauguacc agcggaucuc caacauagag gaccugccac cucucuacac ccucaacaag      960

ccuuugcuca guggcaucag caaugcagaa gcacggcagc cagggaaggc ccccaacuuc     1020

agugucaacu ggacgguagg cgacuccgcu auugagguca ucaacgccac gacugggaag     1080

gaugagcugg gccgcgcguc ccgccugugu aagcacgcgu uguacugucg cuggaugcgu     1140

gugcacggca agguucccuc ccacuuacua cgcuccaaga uuaccaagcc caacguguac     1200

caugagucca agcuggcggc aaaggaguac caggccgcca aggcgcgucu guucacagcc     1260

uucaucaagg cggggcuggg ggccugggug gagaagccca ccgagcagga ccaguucuca     1320

cucacgccug gagguggcgg aucgggaggu ggcggaucgg gagguggcgg aucgggccgc     1380

agccgccuuu uggaagauuu ucgaaacaac cgguacccca auuuacaacu gcgggagauu     1440

gccggacaua uaauggaauu uucccaagac cagcaugggu ccagauucau ucagcugaaa     1500

cuggagcgug ccacaccagc ugagcgccag cuugucuuua augaaauccu ccaggcugcc     1560

uaccaacuca ugguggaugu guuugguugu uacgucauuc agaaguucuu ugaauuuggc     1620

agucuugaac agaagcuggc uuuggcagaa cggauucgag gucacguccu gucauuggca     1680

cuacagaugu auggcucccg uguuauccgc aaagcucuug aguuuauucc uucagaccag     1740

cagaaugaga ugguucggga acuagauggc caugucuuga agugugugaa agaucagaau     1800

ggcugucacg ugguucagaa augcauugaa uguguacagc cccagucuuu gcaauuuauc     1860

aucgaugcgu uuaagggcca gguauuugcc uuauccacac auccuuaugg cucccgagug     1920

auugagagaa uccuggagca cugucucccu gaccagacac ucccuauuuu agaggagcuu     1980

caccagcaca cagagcagcu uguacaggau caauauggau guuauguaau ccaacaugua     2040

cuggagcacg gucguccuga ggauaaaagc aaaauuguag cagaaauccg aggcaaugua     2100

cuuguauuga gucagcacaa auuugcaaac aauguugugc agaagugugu uacucacgcc     2160

ucacguacgg agcgcgcugu gcucaucgau gaggugugca ccaugaacga cgguccccac     2220

agugccuuau acaccaugau gaaggaccag uaugccaacu acguggucca gaagaugauu     2280

gacguggcgg agccaggcca gcggaagauc gucaugcaua agauccgacc ccacaucgca     2340

acucuucgua aguacaccua uggcaagcac auucuggcca agcuggagaa guacuacaug     2400

aagaacggug uugacuuagg gggagguggc ggaucgggag guggcggauc gggagguggc     2460

ggaucgggcc gcagccgccu uuuggaagau uuucgaaaca accgguaccc caauuuacaa     2520

cugcgggaga uugccggaca uauaauggaa uuuucccaag accagcaugg gaacagauuc     2580

auucagcuga aacuggagcg ugccacacca gcugagcgcc agcuugucuu uaaugaaauc     2640

cuccaggcug ccuaccaacu caugguggau guguuuggua auuacgucau ucagaaguuc     2700

uuugaauuug gcagucuuga acagaagcug gcuuuggcag aacggauucg aggucacguc     2760

cugucauugg cacuacagau guauggcucc cguguuaucg agaaagcucu ugaguuuauu     2820

ccuucagacc agcagaauga gaugguucgg gaacuagaug gccaugucuu gaagugugug     2880

aaagaucaga auggcaguca cgugguugag aaaugcauug aauguguaca gccccagucu     2940

uugcaauuua ucaucgaugc guuuaaggga cagguauuug ccuuauccac acauccuuau     3000

ggcucccgag ugauugagag aauccuggag cacugucucc cugaccagac acucccuauu     3060

uuagaggagc uucaccagca cacagagcag cuuguacagg aucaauaugg auguuaugua     3120

auccaacaug uacuggagca cggucguccu gaggauaaaa gcaaaauugu agcagaaauc     3180

cgaggcaaug uacuuguauu gagucagcac aaauuugcaa gcuauguugu gcgcaagugu     3240

guuacucacg ccucacguac ggagcgcgcu gugcucaucg augaggugug caccaugaac     3300

gacggucccc acagugccuu auacaccaug augaaggacc aguaugccug cuacgugguc     3360

cagaagauga uugacguggc ggagccaggc cagcggaaga ucgucaugca uaagauccga     3420

ccccacaucg caacucuucg uaaguacacc uauggcaagc acauucuggc caagcuggag     3480

aaguacuaca ugaagaacgg uguugacuua gggagcggcg gcaagcggcc cgccgccacc     3540

aagaaggccg gccaggccaa gaagaagaag uga                                  3573


<210> 11
<211> 828
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
auggacuaca aggaccacga uggagauuau aaagaccacg acaucgacua uaaggacgac       60

gacgacaaga ugagcgacag cggcgagcag aacuacggcg agagagaguc cagaagcgcc      120

agcagauccg gcuccgcuca cggaagcgga aagagcgcua gacauacccc cgccagaagc      180

agauccaagg aggauucuag aaggagcaga agcaagagca gaucuagaag cgaaucuaga      240

uccagaucua gaagaagcuc uagaaggcac uacacaaggu cuagaagcag aucuagaagc      300

cauagaagaa gcagauccag aagcuacucu agagacuaca gaaggagaca cagccacucc      360

cacagcccua uguccacaag aagaaggcac gugggcaaua gggccaaccc cgacccuaac      420

cccaagaaga agaggaaggu gggcuccggc gucuucggcg aagacggcag cggcccuaag      480

aagaagagga aggugggcag cagcagcauc accaagagac cccacacccc uacccccggc      540

aucuacaugg gcagacccac cuacggcucc ucuagaagga gagacuacua cgacagaggc      600

uacgauagag gcuacgacga uagagauuau uacucuagau ccuacagagg cggcggagga      660

ggcggaggcg gauggagagc ugcccaagac agagaccaga ucuauagaag aaggagcccc      720

agccccuacu auagcagagg cggcuacaga ucuagaucua gaucuagaag cuauagcccc      780

agaagauacg gcggcagcua cccuuacgac gugcccgacu acgccuga                   828


<210> 12
<211> 2964
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 12
auggacuaca aggaccacga uggagauuau aaagaccacg acaucgacua uaaggacgac       60

gacgacaaga ugagcgacag cggcgagcag aacuacggcg agagagaguc cagaagcgcc      120

agcagauccg gcuccgcuca cggaagcgga aagagcgcua gacauacccc cgccagaagc      180

agauccaagg aggauucuag aaggagcaga agcaagagca gaucuagaag cgaaucuaga      240

uccagaucua gaagaagcuc uagaaggcac uacacaaggu cuagaagcag aucuagaagc      300

cauagaagaa gcagauccag aagcuacucu agagacuaca gaaggagaca cagccacucc      360

cacagcccua uguccacaag aagaaggcac gugggcaaua gggccaaccc cgacccuaac      420

cccaagaaga agaggaaggu gggcggaggu ggcggaucgg gcaggagcag gcuuuuggaa      480

gauuuucgaa acaaccgcua ccccaauuua caacugcggg agauugcugg acauauaaug      540

gaauuuuccc aagaccagca uggguccaga uucauucagc ugaaacugga gcgugccaca      600

ccagcugagc gccagcuugu cuucaaugaa auccuccagg cugccuacca acucauggug      660

gauguguuug guaauuacgu cauucagaag uucuuugaau uuggcagucu ugaacagaag      720

cuggcuuugg cagaacggau ucgaggccac guccugucau uggcacuaca gauguauggc      780

ugccguguua uccagaaagc ucuugaguuu auuccuucag accagcagaa ugagaugguu      840

cgggaacuag auggccaugu cuugaagugu gugaaagauc agaauggcaa ucacgugguu      900

cagaaaugca uugaaugugu acagccccag ucuuugcaau uuaucaucga ugcguuuaag      960

ggacagguau uugccuuauc cacacauccu uauggcugcc gagugauuca gagaauccug     1020

gagcacuguc ucccugacca gacacucccu auuuuagagg agcuucacca gcacacagag     1080

cagcuuguac aggaucaaua uggaaauuau guaauccaac auguacugga gcacggucgu     1140

ccugaggaua aaagcaaaau uguagcagaa auccgaggca auguacuugu auugagucag     1200

cacaaauuug caagcaaugu uguggagaag uguguuacuc acgccucacg uacggagcgc     1260

gcugugcuca ucgaugaggu gugcaccaug aacgacgguc cccacagugc cuuauacacc     1320

augaugaagg accaguaugc caacuacgug guccagaaga ugauugacgu ggcggagcca     1380

ggccagcgga agaucgucau gcauaagauc cggccccaca ucgcaacucu ucguaaguac     1440

accuauggca agcacauucu ggccaagcug gagaaguacu acaugaagaa cgguguugac     1500

uuagggggag guggcggauc gggagguggc ggaucgggag guggcggauc gggcaggagc     1560

aggcuuuugg aagauuuucg aaacaaccgc uaccccaauu uacaacugcg ggagauugcu     1620

ggacauauaa uggaauuuuc ccaagaccag caugggucca gauucauuca gcugaaacug     1680

gagcgugcca caccagcuga gcgccagcuu gucuucaaug aaauccucca ggcugccuac     1740

caacucaugg uggauguguu ugguaauuac gucauucaga aguucuuuga auuuggcagu     1800

cuugaacaga agcuggcuuu ggcagaacgg auucgaggcc acguccuguc auuggcacua     1860

cagauguaug gcugccgugu uauccagaaa gcucuugagu uuauuccuuc agaccagcag     1920

aaugagaugg uucgggaacu agauggccau gucuugaagu gugugaaaga ucagaauggc     1980

aaucacgugg uucagaaaug cauugaaugu guacagcccc agucuuugca auuuaucauc     2040

gaugcguuua agggacaggu auuugccuua uccacacauc cuuauggcug ccgagugauu     2100

cagagaaucc uggagcacug ucucccugac cagacacucc cuauuuuaga ggagcuucac     2160

cagcacacag agcagcuugu acaggaucaa uauggaaauu auguaaucca acauguacug     2220

gagcacgguc guccugagga uaaaagcaaa auuguagcag aaauccgagg caauguacuu     2280

guauugaguc agcacaaauu ugcaagcaau guuguggaga aguguguuac ucacgccuca     2340

cguacggagc gcgcugugcu caucgaugag gugugcacca ugaacgacgg uccccacagu     2400

gccuuauaca ccaugaugaa ggaccaguau gccaacuacg ugguccagaa gaugauugac     2460

guggcggagc caggccagcg gaagaucguc augcauaaga uccggcccca caucgcaacu     2520

cuucguaagu acaccuaugg caagcacauu cuggccaagc uggagaagua cuacaugaag     2580

aacgguguug acuuagggag cggcggcggc ccuaagaaga agaggaaggu gggcagcagc     2640

agcaucacca agagacccca caccccuacc cccggcaucu acaugggcag acccaccuac     2700

ggcuccucua gaaggagaga cuacuacgac agaggcuacg auagaggcua cgacgauaga     2760

gauuauuacu cuagauccua cagaggcggc ggaggaggcg gaggcggaug gagagcugcc     2820

caagacagag accagaucua uagaagaagg agccccagcc ccuacuauag cagaggcggc     2880

uacagaucua gaucuagauc uagaagcuau agccccagaa gauacggcgg cagcuacccu     2940

uacgacgugc ccgacuacgc cuga                                            2964


<210> 13
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Met Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro 
1               5                   10                  15      


Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln 
            20                  25                  30          


Asp Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr 
        35                  40                  45              


Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr 
    50                  55                  60                  


Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe 
65                  70                  75                  80  


Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg 
                85                  90                  95      


Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile 
            100                 105                 110         


Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val 
        115                 120                 125             


Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly 
    130                 135                 140                 


Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu 
145                 150                 155                 160 


Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr 
                165                 170                 175     


His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu 
            180                 185                 190         


Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu 
        195                 200                 205             


Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu 
    210                 215                 220                 


Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg 
225                 230                 235                 240 


Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val 
                245                 250                 255     


Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile 
            260                 265                 270         


Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr 
        275                 280                 285             


Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp 
    290                 295                 300                 


Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro 
305                 310                 315                 320 


His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala 
                325                 330                 335     


Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ser 
        355                 360                 365             


Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu 
    370                 375                 380                 


Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly 
385                 390                 395                 400 


Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg 
                405                 410                 415     


Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val 
            420                 425                 430         


Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser 
        435                 440                 445             


Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu 
    450                 455                 460                 


Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala Leu 
465                 470                 475                 480 


Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp 
                485                 490                 495     


Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val 
            500                 505                 510         


Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile 
        515                 520                 525             


Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly 
    530                 535                 540                 


Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr 
545                 550                 555                 560 


Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln 
                565                 570                 575     


Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg 
            580                 585                 590         


Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu 
        595                 600                 605             


Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val 
    610                 615                 620                 


Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys 
625                 630                 635                 640 


Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp 
                645                 650                 655     


Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro 
            660                 665                 670         


Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr 
        675                 680                 685             


Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys 
    690                 695                 700                 


Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
705                 710                 


<210> 14
<211> 404
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Met Leu His Leu Asp Gln Thr Pro Ser Arg Gln Pro Ile Pro Ser Glu 
1               5                   10                  15      


Gly Leu Gln Leu His Leu Pro Gln Val Leu Ala Asp Ala Val Ser Arg 
            20                  25                  30          


Leu Val Leu Gly Lys Phe Gly Asp Leu Thr Asp Asn Phe Ser Ser Pro 
        35                  40                  45              


His Ala Arg Arg Lys Val Leu Ala Gly Val Val Met Thr Thr Gly Thr 
    50                  55                  60                  


Asp Val Lys Asp Ala Lys Val Ile Ser Val Ser Thr Gly Gly Lys Cys 
65                  70                  75                  80  


Ile Asn Gly Glu Tyr Met Ser Asp Arg Gly Leu Ala Leu Asn Asp Cys 
                85                  90                  95      


His Ala Glu Ile Ile Ser Arg Arg Ser Leu Leu Arg Phe Leu Tyr Thr 
            100                 105                 110         


Gln Leu Glu Leu Tyr Leu Asn Asn Lys Asp Asp Gln Lys Arg Ser Ile 
        115                 120                 125             


Phe Gln Lys Ser Glu Arg Gly Gly Phe Arg Leu Lys Glu Asn Val Gln 
    130                 135                 140                 


Phe His Leu Tyr Ile Ser Thr Ser Pro Cys Gly Asp Ala Arg Ile Phe 
145                 150                 155                 160 


Ser Pro His Glu Pro Ile Leu Glu Glu Pro Ala Asp Arg His Pro Asn 
                165                 170                 175     


Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Gln Gly 
            180                 185                 190         


Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly Val 
        195                 200                 205             


Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile Ala 
    210                 215                 220                 


Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe Val 
225                 230                 235                 240 


Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His Gly 
                245                 250                 255     


Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu Asp 
            260                 265                 270         


Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile Ser 
        275                 280                 285             


Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val Asn 
    290                 295                 300                 


Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr Gly 
305                 310                 315                 320 


Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu Tyr 
                325                 330                 335     


Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu Arg 
            340                 345                 350         


Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala Ala 
        355                 360                 365             


Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile Lys 
    370                 375                 380                 


Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln Phe 
385                 390                 395                 400 


Ser Leu Thr Pro 
                


<210> 15
<211> 1190
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Leu His Leu Asp Gln Thr Pro Ser 
        35                  40                  45              


Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro Gln Val 
    50                  55                  60                  


Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly Asp Leu 
65                  70                  75                  80  


Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu Ala Gly 
                85                  90                  95      


Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val Ile Ser 
            100                 105                 110         


Val Ser Thr Gly Gly Lys Cys Ile Asn Gly Glu Tyr Met Ser Asp Arg 
        115                 120                 125             


Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Ser 
    130                 135                 140                 


Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn Asn Lys 
145                 150                 155                 160 


Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly Gly Phe 
                165                 170                 175     


Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr Ser Pro 
            180                 185                 190         


Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu Glu Glu 
        195                 200                 205             


Pro Ala Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr 
    210                 215                 220                 


Lys Ile Glu Ser Gly Gln Gly Thr Ile Pro Val Arg Ser Asn Ala Ser 
225                 230                 235                 240 


Ile Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu Thr Met 
                245                 250                 255     


Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile Gln Gly 
            260                 265                 270         


Ser Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile 
        275                 280                 285             


Leu Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met Tyr Gln 
    290                 295                 300                 


Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys 
305                 310                 315                 320 


Pro Leu Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys 
                325                 330                 335     


Ala Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala Ile Glu 
            340                 345                 350         


Val Ile Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg 
        355                 360                 365             


Leu Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His Gly Lys 
    370                 375                 380                 


Val Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr 
385                 390                 395                 400 


His Glu Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg 
                405                 410                 415     


Leu Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val Glu Lys 
            420                 425                 430         


Pro Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro Gly Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ser Arg Leu Leu 
    450                 455                 460                 


Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile 
465                 470                 475                 480 


Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe 
                485                 490                 495     


Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val 
            500                 505                 510         


Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe 
        515                 520                 525             


Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln 
    530                 535                 540                 


Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala 
545                 550                 555                 560 


Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala Leu Glu Phe Ile 
                565                 570                 575     


Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val 
            580                 585                 590         


Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys 
        595                 600                 605             


Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe 
    610                 615                 620                 


Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val 
625                 630                 635                 640 


Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile 
                645                 650                 655     


Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr 
            660                 665                 670         


Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp 
        675                 680                 685             


Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser 
    690                 695                 700                 


Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala 
705                 710                 715                 720 


Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn 
                725                 730                 735     


Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala 
            740                 745                 750         


Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg 
        755                 760                 765             


Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys 
    770                 775                 780                 


Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met 
785                 790                 795                 800 


Lys Asn Gly Val Asp Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                805                 810                 815     


Ser Gly Gly Gly Gly Ser Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg 
            820                 825                 830         


Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile 
        835                 840                 845             


Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu Lys 
    850                 855                 860                 


Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile 
865                 870                 875                 880 


Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val 
                885                 890                 895     


Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu 
            900                 905                 910         


Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr 
        915                 920                 925             


Gly Cys Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln 
    930                 935                 940                 


Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val 
945                 950                 955                 960 


Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val 
                965                 970                 975     


Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val 
            980                 985                 990         


Phe Ala Leu Ser Thr His Pro Tyr  Gly Cys Arg Val Ile  Gln Arg Ile 
        995                 1000                 1005             


Leu Glu  His Cys Leu Pro Asp  Gln Thr Leu Pro Ile  Leu Glu Glu 
    1010                 1015                 1020             


Leu His  Gln His Thr Glu Gln  Leu Val Gln Asp Gln  Tyr Gly Asn 
    1025                 1030                 1035             


Tyr Val  Ile Gln His Val Leu  Glu His Gly Arg Pro  Glu Asp Lys 
    1040                 1045                 1050             


Ser Lys  Ile Val Ala Glu Ile  Arg Gly Asn Val Leu  Val Leu Ser 
    1055                 1060                 1065             


Gln His  Lys Phe Ala Ser Asn  Val Val Glu Lys Cys  Val Thr His 
    1070                 1075                 1080             


Ala Ser  Arg Thr Glu Arg Ala  Val Leu Ile Asp Glu  Val Cys Thr 
    1085                 1090                 1095             


Met Asn  Asp Gly Pro His Ser  Ala Leu Tyr Thr Met  Met Lys Asp 
    1100                 1105                 1110             


Gln Tyr  Ala Asn Tyr Val Val  Gln Lys Met Ile Asp  Val Ala Glu 
    1115                 1120                 1125             


Pro Gly  Gln Arg Lys Ile Val  Met His Lys Ile Arg  Pro His Ile 
    1130                 1135                 1140             


Ala Thr  Leu Arg Lys Tyr Thr  Tyr Gly Lys His Ile  Leu Ala Lys 
    1145                 1150                 1155             


Leu Glu  Lys Tyr Tyr Met Lys  Asn Gly Val Asp Leu  Gly Ser Gly 
    1160                 1165                 1170             


Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1175                 1180                 1185             


Lys Lys  
    1190 


<210> 16
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Met Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro 
1               5                   10                  15      


Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln 
            20                  25                  30          


Asp Gln His Gly Ser Arg Phe Ile Arg Leu Lys Leu Glu Arg Ala Thr 
        35                  40                  45              


Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr 
    50                  55                  60                  


Gln Leu Met Val Asp Val Phe Gly Ser Tyr Val Ile Glu Lys Phe Phe 
65                  70                  75                  80  


Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg 
                85                  90                  95      


Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile 
            100                 105                 110         


Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val 
        115                 120                 125             


Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly 
    130                 135                 140                 


Cys His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu 
145                 150                 155                 160 


Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr 
                165                 170                 175     


His Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu 
            180                 185                 190         


Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu 
        195                 200                 205             


Gln Leu Val Gln Asp Gln Tyr Gly Cys Tyr Val Ile Gln His Val Leu 
    210                 215                 220                 


Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg 
225                 230                 235                 240 


Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Cys Asn Val Val 
                245                 250                 255     


Gln Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile 
            260                 265                 270         


Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr 
        275                 280                 285             


Met Met Lys Asp Gln Tyr Ala Ser Tyr Val Val Arg Lys Met Ile Asp 
    290                 295                 300                 


Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro 
305                 310                 315                 320 


His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala 
                325                 330                 335     


Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ser 
        355                 360                 365             


Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu 
    370                 375                 380                 


Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly 
385                 390                 395                 400 


Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg 
                405                 410                 415     


Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val 
            420                 425                 430         


Asp Val Phe Gly Cys Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser 
        435                 440                 445             


Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu 
    450                 455                 460                 


Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu 
465                 470                 475                 480 


Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp 
                485                 490                 495     


Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val 
            500                 505                 510         


Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile 
        515                 520                 525             


Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly 
    530                 535                 540                 


Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr 
545                 550                 555                 560 


Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln 
                565                 570                 575     


Asp Gln Tyr Gly Ser Tyr Val Ile Arg His Val Leu Glu His Gly Arg 
            580                 585                 590         


Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu 
        595                 600                 605             


Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val Gln Lys Cys Val 
    610                 615                 620                 


Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys 
625                 630                 635                 640 


Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp 
                645                 650                 655     


Gln Tyr Ala Cys Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro 
            660                 665                 670         


Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr 
        675                 680                 685             


Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys 
    690                 695                 700                 


Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
705                 710                 


<210> 17
<211> 1190
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Leu His Leu Asp Gln Thr Pro Ser 
        35                  40                  45              


Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro Gln Val 
    50                  55                  60                  


Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly Asp Leu 
65                  70                  75                  80  


Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu Ala Gly 
                85                  90                  95      


Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val Ile Ser 
            100                 105                 110         


Val Ser Thr Gly Gly Lys Cys Ile Asn Gly Glu Tyr Met Ser Asp Arg 
        115                 120                 125             


Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Ser 
    130                 135                 140                 


Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn Asn Lys 
145                 150                 155                 160 


Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly Gly Phe 
                165                 170                 175     


Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr Ser Pro 
            180                 185                 190         


Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu Glu Glu 
        195                 200                 205             


Pro Ala Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr 
    210                 215                 220                 


Lys Ile Glu Ser Gly Gln Gly Thr Ile Pro Val Arg Ser Asn Ala Ser 
225                 230                 235                 240 


Ile Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu Thr Met 
                245                 250                 255     


Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile Gln Gly 
            260                 265                 270         


Ser Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile 
        275                 280                 285             


Leu Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met Tyr Gln 
    290                 295                 300                 


Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys 
305                 310                 315                 320 


Pro Leu Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys 
                325                 330                 335     


Ala Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala Ile Glu 
            340                 345                 350         


Val Ile Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg 
        355                 360                 365             


Leu Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His Gly Lys 
    370                 375                 380                 


Val Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr 
385                 390                 395                 400 


His Glu Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg 
                405                 410                 415     


Leu Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val Glu Lys 
            420                 425                 430         


Pro Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro Gly Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ser Arg Leu Leu 
    450                 455                 460                 


Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile 
465                 470                 475                 480 


Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe 
                485                 490                 495     


Ile Arg Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val 
            500                 505                 510         


Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe 
        515                 520                 525             


Gly Ser Tyr Val Ile Glu Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln 
    530                 535                 540                 


Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala 
545                 550                 555                 560 


Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala Leu Glu Phe Ile 
                565                 570                 575     


Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val 
            580                 585                 590         


Leu Lys Cys Val Lys Asp Gln Asn Gly Cys His Val Val Gln Lys Cys 
        595                 600                 605             


Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe 
    610                 615                 620                 


Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val 
625                 630                 635                 640 


Ile Glu Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile 
                645                 650                 655     


Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr 
            660                 665                 670         


Gly Cys Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp 
        675                 680                 685             


Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser 
    690                 695                 700                 


Gln His Lys Phe Ala Cys Asn Val Val Gln Lys Cys Val Thr His Ala 
705                 710                 715                 720 


Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn 
                725                 730                 735     


Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala 
            740                 745                 750         


Ser Tyr Val Val Arg Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg 
        755                 760                 765             


Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys 
    770                 775                 780                 


Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met 
785                 790                 795                 800 


Lys Asn Gly Val Asp Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                805                 810                 815     


Ser Gly Gly Gly Gly Ser Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg 
            820                 825                 830         


Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile 
        835                 840                 845             


Met Glu Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln Leu Lys 
    850                 855                 860                 


Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile 
865                 870                 875                 880 


Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Cys Tyr Val 
                885                 890                 895     


Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu 
            900                 905                 910         


Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr 
        915                 920                 925             


Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln 
    930                 935                 940                 


Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val 
945                 950                 955                 960 


Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val 
                965                 970                 975     


Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val 
            980                 985                 990         


Phe Ala Leu Ser Thr His Pro Tyr  Gly Cys Arg Val Ile  Gln Arg Ile 
        995                 1000                 1005             


Leu Glu  His Cys Leu Pro Asp  Gln Thr Leu Pro Ile  Leu Glu Glu 
    1010                 1015                 1020             


Leu His  Gln His Thr Glu Gln  Leu Val Gln Asp Gln  Tyr Gly Ser 
    1025                 1030                 1035             


Tyr Val  Ile Arg His Val Leu  Glu His Gly Arg Pro  Glu Asp Lys 
    1040                 1045                 1050             


Ser Lys  Ile Val Ala Glu Ile  Arg Gly Asn Val Leu  Val Leu Ser 
    1055                 1060                 1065             


Gln His  Lys Phe Ala Asn Asn  Val Val Gln Lys Cys  Val Thr His 
    1070                 1075                 1080             


Ala Ser  Arg Thr Glu Arg Ala  Val Leu Ile Asp Glu  Val Cys Thr 
    1085                 1090                 1095             


Met Asn  Asp Gly Pro His Ser  Ala Leu Tyr Thr Met  Met Lys Asp 
    1100                 1105                 1110             


Gln Tyr  Ala Cys Tyr Val Val  Gln Lys Met Ile Asp  Val Ala Glu 
    1115                 1120                 1125             


Pro Gly  Gln Arg Lys Ile Val  Met His Lys Ile Arg  Pro His Ile 
    1130                 1135                 1140             


Ala Thr  Leu Arg Lys Tyr Thr  Tyr Gly Lys His Ile  Leu Ala Lys 
    1145                 1150                 1155             


Leu Glu  Lys Tyr Tyr Met Lys  Asn Gly Val Asp Leu  Gly Ser Gly 
    1160                 1165                 1170             


Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1175                 1180                 1185             


Lys Lys  
    1190 


<210> 18
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Met Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro 
1               5                   10                  15      


Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln 
            20                  25                  30          


Asp Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr 
        35                  40                  45              


Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr 
    50                  55                  60                  


Gln Leu Met Val Asp Val Phe Gly Cys Tyr Val Ile Gln Lys Phe Phe 
65                  70                  75                  80  


Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg 
                85                  90                  95      


Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile 
            100                 105                 110         


Arg Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val 
        115                 120                 125             


Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly 
    130                 135                 140                 


Cys His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu 
145                 150                 155                 160 


Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr 
                165                 170                 175     


His Pro Tyr Gly Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu 
            180                 185                 190         


Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu 
        195                 200                 205             


Gln Leu Val Gln Asp Gln Tyr Gly Cys Tyr Val Ile Gln His Val Leu 
    210                 215                 220                 


Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg 
225                 230                 235                 240 


Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Asn Asn Val Val 
                245                 250                 255     


Gln Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile 
            260                 265                 270         


Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr 
        275                 280                 285             


Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp 
    290                 295                 300                 


Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro 
305                 310                 315                 320 


His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala 
                325                 330                 335     


Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ser 
        355                 360                 365             


Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu 
    370                 375                 380                 


Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly 
385                 390                 395                 400 


Asn Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg 
                405                 410                 415     


Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val 
            420                 425                 430         


Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser 
        435                 440                 445             


Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu 
    450                 455                 460                 


Ser Leu Ala Leu Gln Met Tyr Gly Ser Arg Val Ile Glu Lys Ala Leu 
465                 470                 475                 480 


Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp 
                485                 490                 495     


Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser His Val Val 
            500                 505                 510         


Glu Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile 
        515                 520                 525             


Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly 
    530                 535                 540                 


Ser Arg Val Ile Glu Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr 
545                 550                 555                 560 


Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln 
                565                 570                 575     


Asp Gln Tyr Gly Cys Tyr Val Ile Gln His Val Leu Glu His Gly Arg 
            580                 585                 590         


Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu 
        595                 600                 605             


Val Leu Ser Gln His Lys Phe Ala Ser Tyr Val Val Arg Lys Cys Val 
    610                 615                 620                 


Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys 
625                 630                 635                 640 


Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp 
                645                 650                 655     


Gln Tyr Ala Cys Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro 
            660                 665                 670         


Gly Gln Arg Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr 
        675                 680                 685             


Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys 
    690                 695                 700                 


Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
705                 710                 


<210> 19
<211> 1190
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Leu His Leu Asp Gln Thr Pro Ser 
        35                  40                  45              


Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro Gln Val 
    50                  55                  60                  


Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly Asp Leu 
65                  70                  75                  80  


Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu Ala Gly 
                85                  90                  95      


Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val Ile Ser 
            100                 105                 110         


Val Ser Thr Gly Gly Lys Cys Ile Asn Gly Glu Tyr Met Ser Asp Arg 
        115                 120                 125             


Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Ser 
    130                 135                 140                 


Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn Asn Lys 
145                 150                 155                 160 


Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly Gly Phe 
                165                 170                 175     


Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr Ser Pro 
            180                 185                 190         


Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu Glu Glu 
        195                 200                 205             


Pro Ala Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr 
    210                 215                 220                 


Lys Ile Glu Ser Gly Gln Gly Thr Ile Pro Val Arg Ser Asn Ala Ser 
225                 230                 235                 240 


Ile Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu Thr Met 
                245                 250                 255     


Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile Gln Gly 
            260                 265                 270         


Ser Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile 
        275                 280                 285             


Leu Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met Tyr Gln 
    290                 295                 300                 


Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys 
305                 310                 315                 320 


Pro Leu Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys 
                325                 330                 335     


Ala Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala Ile Glu 
            340                 345                 350         


Val Ile Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg 
        355                 360                 365             


Leu Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His Gly Lys 
    370                 375                 380                 


Val Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr 
385                 390                 395                 400 


His Glu Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg 
                405                 410                 415     


Leu Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val Glu Lys 
            420                 425                 430         


Pro Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro Gly Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ser Arg Leu Leu 
    450                 455                 460                 


Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile 
465                 470                 475                 480 


Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe 
                485                 490                 495     


Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val 
            500                 505                 510         


Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe 
        515                 520                 525             


Gly Cys Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln 
    530                 535                 540                 


Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala 
545                 550                 555                 560 


Leu Gln Met Tyr Gly Ser Arg Val Ile Arg Lys Ala Leu Glu Phe Ile 
                565                 570                 575     


Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val 
            580                 585                 590         


Leu Lys Cys Val Lys Asp Gln Asn Gly Cys His Val Val Gln Lys Cys 
        595                 600                 605             


Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe 
    610                 615                 620                 


Lys Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Arg Val 
625                 630                 635                 640 


Ile Glu Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile 
                645                 650                 655     


Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr 
            660                 665                 670         


Gly Cys Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp 
        675                 680                 685             


Lys Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser 
    690                 695                 700                 


Gln His Lys Phe Ala Asn Asn Val Val Gln Lys Cys Val Thr His Ala 
705                 710                 715                 720 


Ser Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn 
                725                 730                 735     


Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala 
            740                 745                 750         


Asn Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg 
        755                 760                 765             


Lys Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys 
    770                 775                 780                 


Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met 
785                 790                 795                 800 


Lys Asn Gly Val Asp Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                805                 810                 815     


Ser Gly Gly Gly Gly Ser Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg 
            820                 825                 830         


Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile 
        835                 840                 845             


Met Glu Phe Ser Gln Asp Gln His Gly Asn Arg Phe Ile Gln Leu Lys 
    850                 855                 860                 


Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile 
865                 870                 875                 880 


Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val 
                885                 890                 895     


Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu 
            900                 905                 910         


Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr 
        915                 920                 925             


Gly Ser Arg Val Ile Glu Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln 
    930                 935                 940                 


Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val 
945                 950                 955                 960 


Lys Asp Gln Asn Gly Ser His Val Val Glu Lys Cys Ile Glu Cys Val 
                965                 970                 975     


Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val 
            980                 985                 990         


Phe Ala Leu Ser Thr His Pro Tyr  Gly Ser Arg Val Ile  Glu Arg Ile 
        995                 1000                 1005             


Leu Glu  His Cys Leu Pro Asp  Gln Thr Leu Pro Ile  Leu Glu Glu 
    1010                 1015                 1020             


Leu His  Gln His Thr Glu Gln  Leu Val Gln Asp Gln  Tyr Gly Cys 
    1025                 1030                 1035             


Tyr Val  Ile Gln His Val Leu  Glu His Gly Arg Pro  Glu Asp Lys 
    1040                 1045                 1050             


Ser Lys  Ile Val Ala Glu Ile  Arg Gly Asn Val Leu  Val Leu Ser 
    1055                 1060                 1065             


Gln His  Lys Phe Ala Ser Tyr  Val Val Arg Lys Cys  Val Thr His 
    1070                 1075                 1080             


Ala Ser  Arg Thr Glu Arg Ala  Val Leu Ile Asp Glu  Val Cys Thr 
    1085                 1090                 1095             


Met Asn  Asp Gly Pro His Ser  Ala Leu Tyr Thr Met  Met Lys Asp 
    1100                 1105                 1110             


Gln Tyr  Ala Cys Tyr Val Val  Gln Lys Met Ile Asp  Val Ala Glu 
    1115                 1120                 1125             


Pro Gly  Gln Arg Lys Ile Val  Met His Lys Ile Arg  Pro His Ile 
    1130                 1135                 1140             


Ala Thr  Leu Arg Lys Tyr Thr  Tyr Gly Lys His Ile  Leu Ala Lys 
    1145                 1150                 1155             


Leu Glu  Lys Tyr Tyr Met Lys  Asn Gly Val Asp Leu  Gly Ser Gly 
    1160                 1165                 1170             


Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1175                 1180                 1185             


Lys Lys  
    1190 


<210> 20
<211> 275
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ser Asp Ser Gly Glu Gln Asn Tyr 
            20                  25                  30          


Gly Glu Arg Glu Ser Arg Ser Ala Ser Arg Ser Gly Ser Ala His Gly 
        35                  40                  45              


Ser Gly Lys Ser Ala Arg His Thr Pro Ala Arg Ser Arg Ser Lys Glu 
    50                  55                  60                  


Asp Ser Arg Arg Ser Arg Ser Lys Ser Arg Ser Arg Ser Glu Ser Arg 
65                  70                  75                  80  


Ser Arg Ser Arg Arg Ser Ser Arg Arg His Tyr Thr Arg Ser Arg Ser 
                85                  90                  95      


Arg Ser Arg Ser His Arg Arg Ser Arg Ser Arg Ser Tyr Ser Arg Asp 
            100                 105                 110         


Tyr Arg Arg Arg His Ser His Ser His Ser Pro Met Ser Thr Arg Arg 
        115                 120                 125             


Arg His Val Gly Asn Arg Ala Asn Pro Asp Pro Asn Pro Lys Lys Lys 
    130                 135                 140                 


Arg Lys Val Gly Ser Gly Val Phe Gly Glu Asp Gly Ser Gly Pro Lys 
145                 150                 155                 160 


Lys Lys Arg Lys Val Gly Ser Ser Ser Ile Thr Lys Arg Pro His Thr 
                165                 170                 175     


Pro Thr Pro Gly Ile Tyr Met Gly Arg Pro Thr Tyr Gly Ser Ser Arg 
            180                 185                 190         


Arg Arg Asp Tyr Tyr Asp Arg Gly Tyr Asp Arg Gly Tyr Asp Asp Arg 
        195                 200                 205             


Asp Tyr Tyr Ser Arg Ser Tyr Arg Gly Gly Gly Gly Gly Gly Gly Gly 
    210                 215                 220                 


Trp Arg Ala Ala Gln Asp Arg Asp Gln Ile Tyr Arg Arg Arg Ser Pro 
225                 230                 235                 240 


Ser Pro Tyr Tyr Ser Arg Gly Gly Tyr Arg Ser Arg Ser Arg Ser Arg 
                245                 250                 255     


Ser Tyr Ser Pro Arg Arg Tyr Gly Gly Ser Tyr Pro Tyr Asp Val Pro 
            260                 265                 270         


Asp Tyr Ala 
        275 


<210> 21
<211> 987
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ser Asp Ser Gly Glu Gln Asn Tyr 
            20                  25                  30          


Gly Glu Arg Glu Ser Arg Ser Ala Ser Arg Ser Gly Ser Ala His Gly 
        35                  40                  45              


Ser Gly Lys Ser Ala Arg His Thr Pro Ala Arg Ser Arg Ser Lys Glu 
    50                  55                  60                  


Asp Ser Arg Arg Ser Arg Ser Lys Ser Arg Ser Arg Ser Glu Ser Arg 
65                  70                  75                  80  


Ser Arg Ser Arg Arg Ser Ser Arg Arg His Tyr Thr Arg Ser Arg Ser 
                85                  90                  95      


Arg Ser Arg Ser His Arg Arg Ser Arg Ser Arg Ser Tyr Ser Arg Asp 
            100                 105                 110         


Tyr Arg Arg Arg His Ser His Ser His Ser Pro Met Ser Thr Arg Arg 
        115                 120                 125             


Arg His Val Gly Asn Arg Ala Asn Pro Asp Pro Asn Pro Lys Lys Lys 
    130                 135                 140                 


Arg Lys Val Gly Gly Gly Gly Gly Ser Gly Arg Ser Arg Leu Leu Glu 
145                 150                 155                 160 


Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala 
                165                 170                 175     


Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile 
            180                 185                 190         


Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe 
        195                 200                 205             


Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly 
    210                 215                 220                 


Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys 
225                 230                 235                 240 


Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu 
                245                 250                 255     


Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro 
            260                 265                 270         


Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu 
        275                 280                 285             


Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile 
    290                 295                 300                 


Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys 
305                 310                 315                 320 


Gly Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile 
                325                 330                 335     


Gln Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu 
            340                 345                 350         


Glu Glu Leu His Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly 
        355                 360                 365             


Asn Tyr Val Ile Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys 
    370                 375                 380                 


Ser Lys Ile Val Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln 
385                 390                 395                 400 


His Lys Phe Ala Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser 
                405                 410                 415     


Arg Thr Glu Arg Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp 
            420                 425                 430         


Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn 
        435                 440                 445             


Tyr Val Val Gln Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys 
    450                 455                 460                 


Ile Val Met His Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr 
465                 470                 475                 480 


Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys 
                485                 490                 495     


Asn Gly Val Asp Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn 
        515                 520                 525             


Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met 
    530                 535                 540                 


Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu 
545                 550                 555                 560 


Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu 
                565                 570                 575     


Gln Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile 
            580                 585                 590         


Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala 
        595                 600                 605             


Glu Arg Ile Arg Gly His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly 
    610                 615                 620                 


Cys Arg Val Ile Gln Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln 
625                 630                 635                 640 


Asn Glu Met Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys 
                645                 650                 655     


Asp Gln Asn Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln 
            660                 665                 670         


Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe 
        675                 680                 685             


Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu 
    690                 695                 700                 


Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His 
705                 710                 715                 720 


Gln His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile 
                725                 730                 735     


Gln His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val 
            740                 745                 750         


Ala Glu Ile Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala 
        755                 760                 765             


Ser Asn Val Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg 
    770                 775                 780                 


Ala Val Leu Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser 
785                 790                 795                 800 


Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln 
                805                 810                 815     


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
            820                 825                 830         


Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys 
        835                 840                 845             


His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp 
    850                 855                 860                 


Leu Gly Ser Gly Gly Gly Pro Lys Lys Lys Arg Lys Val Gly Ser Ser 
865                 870                 875                 880 


Ser Ile Thr Lys Arg Pro His Thr Pro Thr Pro Gly Ile Tyr Met Gly 
                885                 890                 895     


Arg Pro Thr Tyr Gly Ser Ser Arg Arg Arg Asp Tyr Tyr Asp Arg Gly 
            900                 905                 910         


Tyr Asp Arg Gly Tyr Asp Asp Arg Asp Tyr Tyr Ser Arg Ser Tyr Arg 
        915                 920                 925             


Gly Gly Gly Gly Gly Gly Gly Gly Trp Arg Ala Ala Gln Asp Arg Asp 
    930                 935                 940                 


Gln Ile Tyr Arg Arg Arg Ser Pro Ser Pro Tyr Tyr Ser Arg Gly Gly 
945                 950                 955                 960 


Tyr Arg Ser Arg Ser Arg Ser Arg Ser Tyr Ser Pro Arg Arg Tyr Gly 
                965                 970                 975     


Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            980                 985         


<210> 22
<211> 16
<212> RNA
<213> Homo sapiens

<400> 22
aucaugauca agaagc                                                       16


<210> 23
<211> 16
<212> RNA
<213> Homo sapiens

<400> 23
acaggguuuu agacaa                                                       16


<210> 24
<211> 16
<212> RNA
<213> Homo sapiens

<400> 24
acaggguuuu agacaa                                                       16


<210> 25
<211> 70
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 25
ggcuauggca ucgcaacacc uaaaggaucc ucauuaaggu ggguggaaua guauaacaau       60

augcuaaaug                                                              70


<210> 26
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 26
uuuuuuaacu uccuuuauuu uccuuacagg guuuuagaca aaaucaaaaa gaaggaaggu       60

gcucac                                                                  66


<210> 27
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 27
actattccac ccaccgtaat gaggatcctt                                        30


<210> 28
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 28
tcactttcat aatgctgg                                                     18


<210> 29
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Gln Tyr Gly Gly Tyr Val Ile Arg His Val Leu 
1               5                   10      


<210> 30
<211> 351
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Glu Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Leu Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Val Ile Asn Glu Met 
        115                 120                 125             


Val Arg Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn 
    130                 135                 140                 


Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser 
145                 150                 155                 160 


Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Ala Leu Ser 
                165                 170                 175     


Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys 
            180                 185                 190         


Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr 
        195                 200                 205             


Glu Gln Leu Val Gln Asp Gln Tyr Gly Gly Tyr Val Ile Arg His Val 
    210                 215                 220                 


Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala Glu Ile 
225                 230                 235                 240 


Arg Gly Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val 
                245                 250                 255     


Val Glu Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu 
            260                 265                 270         


Ile Asp Glu Val Cys Thr Met Asn Asp Gly Pro His Ser Ala Leu Tyr 
        275                 280                 285             


Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile 
    290                 295                 300                 


Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His Lys Ile Arg 
305                 310                 315                 320 


Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu 
                325                 330                 335     


Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp Leu Gly 
            340                 345                 350     


<210> 31
<211> 36
<212> PRT
<213> Homo sapiens

<400> 31
His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg Phe Ile Gln 
1               5                   10                  15      


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            20                  25                  30          


Glu Ile Leu Gln 
        35      


<210> 32
<211> 36
<212> PRT
<213> Homo sapiens

<400> 32
His Val Leu Ser Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
1               5                   10                  15      


Lys Ala Leu Glu Phe Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg 
            20                  25                  30          


Glu Leu Asp Gly 
        35      


<210> 33
<211> 36
<212> PRT
<213> Homo sapiens

<400> 33
Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln 
1               5                   10                  15      


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
            20                  25                  30          


Glu Leu His Gln 
        35      


<210> 34
<211> 43
<212> PRT
<213> Homo sapiens

<400> 34
Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
1               5                   10                  15      


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            20                  25                  30          


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser 
        35                  40              


<210> 35
<211> 36
<212> PRT
<213> Homo sapiens

<400> 35
Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln 
1               5                   10                  15      


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            20                  25                  30          


Arg Ile Arg Gly 
        35      


<210> 36
<211> 36
<212> PRT
<213> Homo sapiens

<400> 36
His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln 
1               5                   10                  15      


Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp 
            20                  25                  30          


Ala Phe Lys Gly 
        35      


<210> 37
<211> 36
<212> PRT
<213> Homo sapiens

<400> 37
His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln 
1               5                   10                  15      


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
            20                  25                  30          


Glu Ile Arg Gly 
        35      


<210> 38
<211> 66
<212> PRT
<213> Homo sapiens

<400> 38
Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln 
1               5                   10                  15      


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
            20                  25                  30          


Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys 
        35                  40                  45              


His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp 
    50                  55                  60                  


Leu Gly 
65      


<210> 39
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT 
<222> (4)..(4)
<223> /replace="Ala" or "Ser" or "Thr" or "Cys"

<220>
<221> SITE
<222> (1)..(11)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 39
Gln His Gly Gly Arg Phe Ile Arg Leu Lys Leu 
1               5                   10      


<210> 40
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT 
<222> (4)..(4)
<223> /replace="Ala" or "Ser" or "Thr" or "Cys"

<220>
<221> SITE
<222> (1)..(11)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 40
Val Phe Gly Gly Tyr Val Ile Arg Lys Phe Phe 
1               5                   10      


<210> 41
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT 
<222> (4)..(4)
<223> /replace="Ala" or "Ser" or "Thr" or "Cys"

<220>
<221> SITE
<222> (1)..(11)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 41
Met Tyr Gly Gly Arg Val Ile Arg Lys Ala Leu 
1               5                   10      


<210> 42
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT 
<222> (4)..(4)
<223> /replace="Ala" or "Ser" or "Thr" or "Cys"

<220>
<221> SITE
<222> (1)..(11)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 42
Gln Asn Gly Gly His Val Val Arg Lys Cys Ile 
1               5                   10      


<210> 43
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT 
<222> (4)..(4)
<223> /replace="Ala" or "Ser" or "Thr" or "Cys"

<220>
<221> SITE
<222> (1)..(11)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 43
Pro Tyr Gly Gly Arg Val Ile Arg Arg Ile Leu 
1               5                   10      


<210> 44
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT 
<222> (4)..(4)
<223> /replace="Ala" or "Ser" or "Thr" or "Cys"

<220>
<221> SITE
<222> (1)..(11)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 44
Gln Tyr Gly Gly Tyr Val Ile Arg His Val Leu 
1               5                   10      


<210> 45
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT 
<222> (4)..(4)
<223> /replace="Ala" or "Ser" or "Thr" or "Cys"

<220>
<221> SITE
<222> (1)..(11)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 45
Lys Phe Ala Gly Asn Val Val Arg Lys Cys Val 
1               5                   10      


<210> 46
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT 
<222> (4)..(4)
<223> /replace="Ala" or "Ser" or "Thr" or "Cys"

<220>
<221> SITE
<222> (1)..(11)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 46
Gln Tyr Ala Gly Tyr Val Val Arg Lys Met Ile 
1               5                   10      


<210> 47
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 48
<211> 34
<212> PRT
<213> Mus musculus

<400> 48
Ser Asn His Val Glu Val Asn Phe Leu Glu Lys Phe Thr Thr Glu Arg 
1               5                   10                  15      


Tyr Phe Arg Pro Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
            20                  25                  30          


Ser Arg 
        


<210> 49
<211> 34
<212> PRT
<213> Homo sapiens

<400> 49
Thr Asn His Val Glu Val Asn Phe Ile Lys Lys Phe Thr Ser Glu Arg 
1               5                   10                  15      


Asp Phe His Pro Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 
            20                  25                  30          


Ser Gln 
        


<210> 50
<211> 34
<212> PRT
<213> Oryctolagus cuniculus

<400> 50
Thr Asn His Val Glu Val Asn Phe Leu Glu Lys Leu Thr Ser Glu Gly 
1               5                   10                  15      


Arg Leu Gly Pro Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 
            20                  25                  30          


Ser Met 
        


<210> 51
<211> 32
<212> PRT
<213> Homo sapiens

<400> 51
Ala Ala His Ala Glu Glu Ala Phe Phe Asn Thr Ile Leu Pro Ala Phe 
1               5                   10                  15      


Asp Pro Thr Trp Tyr Val Ser Ser Ser Pro Cys Ala Ala Cys Ala Asp 
            20                  25                  30          


<210> 52
<211> 33
<212> PRT
<213> Mus musculus

<400> 52
Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr Ile Ser Asp Trp Asp 
1               5                   10                  15      


Leu Asp Pro Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala 
            20                  25                  30          


Arg 
    


<210> 53
<211> 34
<212> PRT
<213> Homo sapiens

<400> 53
Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu 
1               5                   10                  15      


Tyr Ser Glu Leu His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly 
            20                  25                  30          


Ala Leu 
        


<210> 54
<211> 34
<212> PRT
<213> Xenopus laevis

<400> 54
Asp Cys His Ala Glu Val Val Ser Arg Arg Gly Phe Ile Arg Phe Leu 
1               5                   10                  15      


Tyr Ser Gln Leu His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly 
            20                  25                  30          


Ala Leu 
        


<210> 55
<211> 34
<212> PRT
<213> Homo sapiens

<400> 55
Asp Cys His Ala Glu Ile Ile Ser Arg Arg Ser Leu Leu Arg Phe Leu 
1               5                   10                  15      


Tyr Thr Gln Leu His Leu Tyr Ile Ser Thr Ser Pro Cys Gly Asp Ala 
            20                  25                  30          


Arg Ile 
        


<210> 56
<211> 34
<212> PRT
<213> Rattus sp.

<400> 56
Asp Cys His Ala Glu Ile Ile Ser Arg Arg Ser Leu Leu Arg Phe Leu 
1               5                   10                  15      


Tyr Ala Gln Leu His Leu Tyr Ile Ser Thr Ser Pro Cys Gly Asp Ala 
            20                  25                  30          


Arg Ile 
        


<210> 57
<211> 34
<212> PRT
<213> Rattus sp.

<400> 57
Asp Cys His Ala Glu Ile Val Ala Arg Arg Ala Phe Leu His Phe Leu 
1               5                   10                  15      


Tyr Thr Gln Leu His Leu Tyr Val Ser Thr Ser Pro Cys Gly Asp Ala 
            20                  25                  30          


Arg Leu 
        


<210> 58
<211> 34
<212> PRT
<213> Caenorhabditis elegans

<400> 58
Asp Cys His Ala Glu Ile Leu Ala Arg Arg Gly Leu Leu Arg Phe Leu 
1               5                   10                  15      


Tyr Ser Glu Val His Leu Phe Ile Asn Thr Ala Pro Cys Gly Val Ala 
            20                  25                  30          


Arg Ile 
        


<210> 59
<211> 34
<212> PRT
<213> Drosophila melanogaster

<400> 59
Asp Ser His Ala Glu Ile Val Ser Arg Arg Cys Leu Leu Lys Tyr Leu 
1               5                   10                  15      


Tyr Ala Gln Phe His Leu Tyr Ile Asn Thr Ala Pro Cys Gly Asp Ala 
            20                  25                  30          


Arg Ile 
        


<210> 60
<211> 34
<212> PRT
<213> Homo sapiens

<400> 60
Val Cys His Ala Glu Leu Asn Ala Ile Met Asn Lys Asn Ser Thr Asp 
1               5                   10                  15      


Val Lys Gly Cys Ser Met Tyr Val Ala Leu Phe Pro Cys Asn Glu Cys 
            20                  25                  30          


Ala Lys 
        


<210> 61
<211> 35
<212> PRT
<213> Saccharomyces cerevisiae

<400> 61
Cys Leu His Ala Glu Glu Asn Ala Leu Leu Glu Ala Gly Arg Asp Arg 
1               5                   10                  15      


Val Gly Gln Asn Ala Thr Leu Tyr Cys Asp Thr Cys Pro Cys Leu Thr 
            20                  25                  30          


Cys Ser Val 
        35  


<210> 62
<211> 34
<212> PRT
<213> Homo sapiens

<400> 62
Gly Ile Cys Ala Glu Arg Thr Ala Ile Gln Lys Ala Val Ser Glu Gly 
1               5                   10                  15      


Tyr Lys Asp Phe Met Gln Asp Asp Phe Ile Ser Pro Cys Gly Ala Cys 
            20                  25                  30          


Arg Gln 
        


<210> 63
<211> 34
<212> PRT
<213> Escherichia coli

<400> 63
Thr Val His Ala Glu Gln Ser Ala Ile Ser His Ala Trp Leu Ser Gly 
1               5                   10                  15      


Glu Lys Ala Leu Ala Ile Thr Val Asn Tyr Thr Pro Cys Gly His Cys 
            20                  25                  30          


Arg Gln 
        


<210> 64
<211> 34
<212> PRT
<213> Caenorhabditis elegans

<400> 64
Val Val His Ala Glu Met Asn Ala Ile Ile Asn Lys Arg Cys Thr Thr 
1               5                   10                  15      


Leu His Asp Cys Thr Val Tyr Val Thr Leu Phe Pro Cys Asn Lys Cys 
            20                  25                  30          


Ala Gln 
        


<210> 65
<211> 34
<212> PRT
<213> Escherichia coli

<400> 65
Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met 
1               5                   10                  15      


Gln Asn Tyr Arg Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys 
            20                  25                  30          


Ala Gly 
        


<210> 66
<211> 34
<212> PRT
<213> Haemophilus influenzae

<400> 66
Thr Ala His Ala Glu Ile Ile Ala Leu Arg Asn Gly Ala Lys Asn Ile 
1               5                   10                  15      


Gln Asn Tyr Arg Thr Leu Tyr Val Thr Leu Glu Pro Cys Thr Met Cys 
            20                  25                  30          


Ala Gly 
        


<210> 67
<211> 34
<212> PRT
<213> Homo sapiens

<400> 67
Asp Ser His Ala Glu Val Ile Ala Arg Arg Ser Phe Gln Arg Tyr Leu 
1               5                   10                  15      


Leu His Gln Leu Val Phe Phe Ser Ser His Thr Pro Cys Gly Asp Ala 
            20                  25                  30          


Ser Ile 
        


<210> 68
<211> 34
<212> PRT
<213> Saccharomyces cerevisiae

<400> 68
Asp Cys His Ala Glu Ile Leu Ala Leu Arg Gly Ala Asn Thr Val Leu 
1               5                   10                  15      


Leu Asn Arg Ile Ala Leu Tyr Ile Ser Arg Leu Pro Cys Gly Asp Ala 
            20                  25                  30          


Ser Met 
        


<210> 69
<211> 34
<212> PRT
<213> Drosophila melanogaster

<400> 69
Asp Ser His Ala Glu Val Leu Ala Arg Arg Gly Phe Leu Arg Phe Leu 
1               5                   10                  15      


Tyr Gln Glu Leu His Phe Leu Ser Thr Gln Thr Pro Cys Gly Asp Ala 
            20                  25                  30          


Cys Ile 
        


<210> 70
<211> 35
<212> PRT
<213> Homo sapiens

<400> 70
Thr Arg His Ala Glu Met Val Ala Ile Asp Gln Val Leu Asp Trp Cys 
1               5                   10                  15      


Arg Gln Ser Gly Thr Val Leu Tyr Val Thr Val Glu Pro Cys Ile Met 
            20                  25                  30          


Cys Ala Ala 
        35  


<210> 71
<211> 34
<212> PRT
<213> Saccharomyces cerevisiae

<400> 71
Val Ala His Ala Glu Phe Met Gly Ile Asp Gln Ile Lys Ala Met Leu 
1               5                   10                  15      


Gly Ser Arg Gly Thr Leu Tyr Val Thr Val Glu Pro Cys Ile Met Cys 
            20                  25                  30          


Ala Ser 
        


<210> 72
<211> 35
<212> PRT
<213> Homo sapiens

<400> 72
Leu Leu His Ala Val Met Val Cys Val Asp Leu Val Ala Arg Gly Gln 
1               5                   10                  15      


Gly Arg Gly Gly Tyr Asp Leu Tyr Val Thr Arg Glu Pro Cys Ala Met 
            20                  25                  30          


Cys Ala Met 
        35  


<210> 73
<211> 34
<212> PRT
<213> Saccharomyces cerevisiae

<400> 73
Ile Asp His Ser Val Met Val Gly Ile Arg Ala Val Gly Glu Arg Leu 
1               5                   10                  15      


Arg Glu Gly Val Asp Val Tyr Leu Thr His Glu Pro Cys Ser Met Cys 
            20                  25                  30          


Ser Met 
        


<210> 74
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cleavable linker sequence"

<400> 74
Cys Pro Arg Ser Cys 
1               5   


<210> 75
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 75
His Ile Met Glu Phe Ser Gln Asp Gln His Gly Cys Arg Phe Ile Arg 
1               5                   10                  15      


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            20                  25                  30          


Glu Ile Leu Gln 
        35      


<210> 76
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 76
Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Arg Val Ile Gln 
1               5                   10                  15      


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            20                  25                  30          


Arg Ile Arg Gly 
        35      


<210> 77
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 77
Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Ser Asn Val Ile Glu 
1               5                   10                  15      


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            20                  25                  30          


Arg Ile Arg Gly 
        35      


<210> 78
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 78
His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser Arg Val Val Gln 
1               5                   10                  15      


Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp 
            20                  25                  30          


Ala Phe Lys Gly 
        35      


<210> 79
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 79
Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Cys Arg Val Ile Gln 
1               5                   10                  15      


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
            20                  25                  30          


Glu Leu His Gln 
        35      


<210> 80
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 80
His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Asn Val Ile Glu 
1               5                   10                  15      


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
            20                  25                  30          


Glu Ile Arg Gly 
        35      


<210> 81
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 81
Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu 
1               5                   10                  15      


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            20                  25                  30          


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser 
        35                  40              


<210> 82
<211> 66
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 82
Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Cys Tyr Val Val Arg 
1               5                   10                  15      


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
            20                  25                  30          


Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys 
        35                  40                  45              


His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp 
    50                  55                  60                  


Leu Gly 
65      


<210> 83
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 83
ccatcgaaag tgctgaggat                                                   20


<210> 84
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 84
agggctctgc actcctcata                                                   20


<210> 85
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 85
His Ile Met Glu Phe Ser Gln Asp Gln His Gly Asn Tyr Phe Ile Gln 
1               5                   10                  15      


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            20                  25                  30          


Glu Ile Leu Gln 
        35      


<210> 86
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 86
Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Asn Tyr Val Ile Gln 
1               5                   10                  15      


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            20                  25                  30          


Arg Ile Arg Gly 
        35      


<210> 87
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 87
Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Cys Arg Val Ile Gln 
1               5                   10                  15      


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            20                  25                  30          


Arg Ile Arg Gly 
        35      


<210> 88
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 88
His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Ser Asn Val Val Glu 
1               5                   10                  15      


Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp 
            20                  25                  30          


Ala Phe Lys Gly 
        35      


<210> 89
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 89
His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Cys Tyr Val Ile Arg 
1               5                   10                  15      


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
            20                  25                  30          


Glu Ile Arg Gly 
        35      


<210> 90
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 90
Asn Val Leu Val Leu Ser Gln His Lys Phe Ala Cys Arg Val Val Gln 
1               5                   10                  15      


Lys Cys Val Thr His Ala Ser Arg Thr Glu Arg Ala Val Leu Ile Asp 
            20                  25                  30          


Glu Val Cys Thr Met Asn Asp Gly Pro His Ser 
        35                  40              


<210> 91
<211> 66
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 91
Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Cys Arg Val Val Gln 
1               5                   10                  15      


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
            20                  25                  30          


Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys 
        35                  40                  45              


His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp 
    50                  55                  60                  


Leu Gly 
65      


<210> 92
<211> 105
<212> DNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      EBNA1 GAr sequence"

<400> 92
taaaggagca ggagcaggag cgggaggggc aggagcagga ggggcaggag caggaggagg       60

ggcaggagca ggaggagggg caggaggggc aggaggggca ggaat                      105


<210> 93
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 93
His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Asn Phe Ile Glu 
1               5                   10                  15      


Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu Val Phe Asn 
            20                  25                  30          


Glu Ile Leu Gln 
        35      


<210> 94
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 94
Ala Ala Tyr Gln Leu Met Val Asp Val Phe Gly Cys Tyr Val Ile Arg 
1               5                   10                  15      


Lys Phe Phe Glu Phe Gly Ser Leu Glu Gln Lys Leu Ala Leu Ala Glu 
            20                  25                  30          


Arg Ile Arg Gly 
        35      


<210> 95
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 95
Gln Val Phe Ala Leu Ser Thr His Pro Tyr Gly Ser Asn Val Ile Glu 
1               5                   10                  15      


Arg Ile Leu Glu His Cys Leu Pro Asp Gln Thr Leu Pro Ile Leu Glu 
            20                  25                  30          


Glu Leu His Gln 
        35      


<210> 96
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 96
His Thr Glu Gln Leu Val Gln Asp Gln Tyr Gly Ser Arg Val Ile Gln 
1               5                   10                  15      


His Val Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ala 
            20                  25                  30          


Glu Ile Arg Gly 
        35      


<210> 97
<211> 66
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 97
Ala Leu Tyr Thr Met Met Lys Asp Gln Tyr Ala Ser Asn Val Val Glu 
1               5                   10                  15      


Lys Met Ile Asp Val Ala Glu Pro Gly Gln Arg Lys Ile Val Met His 
            20                  25                  30          


Lys Ile Arg Pro His Ile Ala Thr Leu Arg Lys Tyr Thr Tyr Gly Lys 
        35                  40                  45              


His Ile Leu Ala Lys Leu Glu Lys Tyr Tyr Met Lys Asn Gly Val Asp 
    50                  55                  60                  


Leu Gly 
65      


<210> 98
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 98
tttttttttt tttttttt                                                     18


<210> 99
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 99
gggatatcta tcatgatcaa gaagcctcag                                        30


<210> 100
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (29)..(29)
<223> Inosine

<400> 100
gggatatcta tcatgatcaa gaagcctcng                                        30


<210> 101
<211> 34
<212> DNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      EBNA1 sequence"

<400> 101
gccccccacg gggacccacg gaggagggga gggc                                   34


<210> 102
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
gccccccacg gggacccacg gaggagggga gggc                                   34


<210> 103
<211> 32
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (11)..(11)
<223> Inosine 

<220>
<221> modified_base
<222> (14)..(14)
<223> Inosine 

<400> 103
gcccgacgag ncgnggcccc gcgaggucgg gc                                     32


