                         SEQUENCE LISTING

<110>  Bharat Biotech International Limited
 
<120>  A Chimeric Therapeutic Vaccine

<130>  P-18-680-IN

<140>  201841020522
<141>  2018-11-30

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  1698
<212>  DNA
<213>  Chimeric Sequence

<400>  1
atgaattccg atagcgaatg tcctctaagt catgatggtt attgtttaca tgatggtgtt       60

tgtatgtata ttgaagcttt agataaatat gcttgtaatt gtgttgtcgg ttatattggt      120

gaacgttgtc aatatcgtga tttaaaatgg tgggaattac gtgaagctgc tgctaaaccg      180

gctcaggtta tcaacaccaa ctctctgtct ctgctgaccc agaacaacct gaacaaatct      240

cagtctgctc tgggtaccgc tatcgaacgt ctgtcttctg gtctgcgtat caactctgct      300

aaagacgacg ctgctggtca ggctatcgct aaccgtttca ccgctaacat caaaggtctg      360

acccaggctt ctcgtaacgc taacgacggt atctctatcg ctcagaccac cgaaggtgct      420

ctgaacgaaa tcaacaacaa cctgcaacgt gttcgtgaac tggctgttca gtctgctaac      480

tctaccaact ctcagtctga cctggactct atccaggctg aaatcaccca gcgtctgaac      540

gaaatcgacc gtgtttctgg tcgtacccag ttcaacggtg ttaaagttct ggctcaggac      600

aacaccctga ccatccaggt tggtgctaac gacggtgaaa ccatcgacat cgacctgaaa      660

cagatcaact ctcagaccct gggtctggac tctctgaacg ttcagaaagc ttacgacgtt      720

aaagacaccg ctgttaccac caaagcttac gctaacaacg gtaccaccct ggacgtttct      780

ggtctggacg acgctgctat caaagctgct accggtggta ccaacggtac cgcttctgtt      840

accggtggtg ctgttaaatt cgacgctgac aacaacaaat acttcgttac catcggtggt      900

ttcaccggtg ctgacgctgc taaaaacggt gactacgaag ttaacgttgc taccgacggt      960

accgttaccc tggctgctgg tgctaccaaa accaccatgc cggctggtgc taccaccaaa     1020

accgaagttc aggaactgaa agacaccccg gctgttgttt ctgctgacgc taaaaacgct     1080

ctgatcgctg gtggtgttga cgctaccgac gctaacggtg ctgaactggt taaaatgtct     1140

tacaccgaca aaaacggtaa aaccatcgaa ggtggttacg ctctgaaagc tggtgacaaa     1200

tactacgctg ctgactacga cgaagctacc ggtgctatca aagctaaaac cacctcttac     1260

accgctgctg acggtaccac caaaaccgct gctaaccagc tgggtggtgt tgacggtaaa     1320

accgaagttg ttaccatcga cggtaaaacc tacaacgctt ctaaagctgc tggtcacgac     1380

ttcaaagctc agccggaact ggctgaagct gctgctaaaa ccaccgaaaa cccgctgcaa     1440

aaaatcgacg ctgctctggc tcaggttgac gctctgcgtt ctgacctggg tgctgttcag     1500

aaccgtttca actctgctat caccaacctg ggtaacaccg ttaacaacct gtctgaagct     1560

cgttctcgta tcgaagactc tgactacgct accgaagttt ctaacatgtc tcgtgctcag     1620

atcctgcaac aggctggtac ctctgttctg gctcaggcta accaggttcc gcagaacgtt     1680

ctgtctctgc tgcgttaa                                                   1698


<210>  2
<211>  1017
<212>  DNA
<213>  Chimeric Sequence

<400>  2
atgaattccg atagcgaatg tcctctaagt catgatggtt attgtttaca tgatggtgtt       60

tgtatgtata ttgaagcttt agataaatat gcttgtaatt gtgttgtcgg ttatattggt      120

gaacgttgtc aatatcgtga tttaaaatgg tgggaattac gtgaagctgc tgctaaaccg      180

gctcaggtta tcaacaccaa ctctctgtct ctgctgaccc agaacaacct gaacaaatct      240

cagtctgctc tgggtaccgc tatcgaacgt ctgtcttctg gtctgcgtat caactctgct      300

aaagacgacg ctgctggtca ggctatcgct aaccgtttca ccgctaacat caaaggtctg      360

acccaggctt ctcgtaacgc taacgacggt atctctatcg ctcagaccac cgaaggtgct      420

ctgaacgaaa tcaacaacaa cctgcaacgt gttcgtgaac tggctgttca gtctgctaac      480

tctaccaact ctcagtctga cctggactct atccaggctg aaatcaccca gcgtctgaac      540

gaaatcgacc gtgtttctgg tcgtacccag ttcaacggtg ttaaagttct ggctcaggac      600

aacaccctga ccatccaggt tggtgctaac gacggtgaaa ccatcgacat cgacctgaaa      660

cagatcaact ctcagaccct gggtctggac tctctgaacg ttcagaaagc tagcgaactg      720

gctgaagctg ctgctaaaac caccgaaaac ccgctgcaaa aaatcgacgc tgctctggct      780

caggttgacg ctctgcgttc tgacctgggt gctgttcaga accgtttcaa ctctgctatc      840

accaacctgg gtaacaccgt taacaacctg tctgaagctc gttctcgtat cgaagactct      900

gactacgcta ccgaagtttc taacatgtct cgtgctcaga tcctgcaaca ggctggtacc      960

tctgttctgg ctcaggctaa ccaggttccg cagaacgttc tgtctctgct gcgttaa        1017


<210>  3
<211>  1401
<212>  DNA
<213>  Chimeric Sequence

<400>  3
atgaattccg atagcgaatg tcctctaagt catgatggtt attgtttaca tgatggtgtt       60

tgtatgtata ttgaagcttt agataaatat gcttgtaatt gtgttgtcgg ttatattggt      120

gaacgttgtc aatatcgtga tttaaaatgg tgggaattac gtgaagctgc tgctaaaccg      180

gctcaggtta tcaacaccaa ctctctgtct ctgctgaccc agaacaacct gaacaaatct      240

cagtctgctc tgggtaccgc tatcgaacgt ctgtcttctg gtctgcgtat caactctgct      300

aaagacgacg ctgctggtca ggctatcgct aaccgtttca ccgctaacat caaaggtctg      360

acccaggctt ctcgtaacgc taacgacggt atctctatcg ctcagaccac cgaaggtgct      420

ctgaacgaaa tcaacaacaa cctgcaacgt gttcgtgaac tggctgttca gtctgctaac      480

tctaccaact ctcagtctga cctggactct atccaggctg aaatcaccca gcgtctgaac      540

gaaatcgacc gtgtttctgg tcgtacccag ttcaacggtg ttaaagttct ggctcaggac      600

aacaccctga ccatccaggt tggtgctaac gacggtgaaa ccatcgacat cgacctgaaa      660

cagatcaact ctcagaccct gggtctggac tctctgaacg ttcagaaagc ttacgacgtt      720

aaagacaccg ctgctagcct gaaagacacc ccggctgttg tttctgctga cgctaaaaac      780

gctctgatcg ctggtggtgt tgacgctacc gacgctaacg gtgctgaact ggttaaaatg      840

tcttacaccg acaaaaacgg taaaaccatc gaaggtggtt acgctctgaa agctggtgac      900

aaatactacg ctgctgacta cgacgaagct accggtgcta tcaaagctaa aaccacctct      960

tacaccgctg ctgacggtac caccaaaacc gctgctaacc agctgggtgg tgttgacggt     1020

aaaaccgaag ttgttaccat cgacggtaaa acctacaacg cttctaaagc tgctggtcac     1080

gacttcaaag ctcagccgga actggctgaa gctgctgcta aaaccaccga aaacccgctg     1140

caaaaaatcg acgctgctct ggctcaggtt gacgctctgc gttctgacct gggtgctgtt     1200

cagaaccgtt tcaactctgc tatcaccaac ctgggtaaca ccgttaacaa cctgtctgaa     1260

gctcgttctc gtatcgaaga ctctgactac gctaccgaag tttctaacat gtctcgtgct     1320

cagatcctgc aacaggctgg tacctctgtt ctggctcagg ctaaccaggt tccgcagaac     1380

gttctgtctc tgctgcgtta a                                               1401


<210>  4
<211>  1185
<212>  DNA
<213>  Chimeric Sequence

<400>  4
atgaattccg atagcgaatg tcctctaagt catgatggtt attgtttaca tgatggtgtt       60

tgtatgtata ttgaagcttt agataaatat gcttgtaatt gtgttgtcgg ttatattggt      120

gaacgttgtc aatatcgtga tttaaaatgg tgggaattac gtgaagctgc tgctaaaccg      180

gctcaggtta tcaacaccaa ctctctgtct ctgctgaccc agaacaacct gaacaaatct      240

cagtctgctc tgggtaccgc tatcgaacgt ctgtcttctg gtctgcgtat caactctgct      300

aaagacgacg ctgctggtca ggctatcgct aaccgtttca ccgctaacat caaaggtctg      360

acccaggctt ctcgtaacgc taacgacggt atctctatcg ctcagaccac cgaaggtgct      420

ctgaacgaaa tcaacaacaa cctgcaacgt gttcgtgaac tggctgttca gtctgctaac      480

tctaccaact ctcagtctga cctggactct atccaggctg aaatcaccca gcgtctgaac      540

gaaatcgacc gtgtttctgg tcgtacccag ttcaacggtg ttaaagttct ggctcaggac      600

aacaccctga ccatccaggt tggtgctaac gacggtgaaa ccatcgacat cgacctgaaa      660

cagatcaact ctcagaccct gggtctggac tctctgaacg ttcagaaagc tagcatgaat      720

tccgatagcg aatgtcctct aagtcatgat ggttattgtt tacatgatgg tgtttgtatg      780

tatattgaag ctttagataa atatgcttgt aattgtgttg tcggttatat tggtgaacgt      840

tgtcaatatc gtgatttaaa atggtgggaa ttacgtgcta gcgaactggc tgaagctgct      900

gctaaaacca ccgaaaaccc gctgcaaaaa atcgacgctg ctctggctca ggttgacgct      960

ctgcgttctg acctgggtgc tgttcagaac cgtttcaact ctgctatcac caacctgggt     1020

aacaccgtta acaacctgtc tgaagctcgt tctcgtatcg aagactctga ctacgctacc     1080

gaagtttcta acatgtctcg tgctcagatc ctgcaacagg ctggtacctc tgttctggct     1140

caggctaacc aggttccgca gaacgttctg tctctgctgc gttaa                     1185


<210>  5
<211>  1569
<212>  DNA
<213>  Chimeric Sequence

<400>  5
atgaattccg atagcgaatg tcctctaagt catgatggtt attgtttaca tgatggtgtt       60

tgtatgtata ttgaagcttt agataaatat gcttgtaatt gtgttgtcgg ttatattggt      120

gaacgttgtc aatatcgtga tttaaaatgg tgggaattac gtgaagctgc tgctaaaccg      180

gctcaggtta tcaacaccaa ctctctgtct ctgctgaccc agaacaacct gaacaaatct      240

cagtctgctc tgggtaccgc tatcgaacgt ctgtcttctg gtctgcgtat caactctgct      300

aaagacgacg ctgctggtca ggctatcgct aaccgtttca ccgctaacat caaaggtctg      360

acccaggctt ctcgtaacgc taacgacggt atctctatcg ctcagaccac cgaaggtgct      420

ctgaacgaaa tcaacaacaa cctgcaacgt gttcgtgaac tggctgttca gtctgctaac      480

tctaccaact ctcagtctga cctggactct atccaggctg aaatcaccca gcgtctgaac      540

gaaatcgacc gtgtttctgg tcgtacccag ttcaacggtg ttaaagttct ggctcaggac      600

aacaccctga ccatccaggt tggtgctaac gacggtgaaa ccatcgacat cgacctgaaa      660

cagatcaact ctcagaccct gggtctggac tctctgaacg ttcagaaagc ttacgacgtt      720

aaagacaccg ctgctagcat gaattccgat agcgaatgtc ctctaagtca tgatggttat      780

tgtttacatg atggtgtttg tatgtatatt gaagctttag ataaatatgc ttgtaattgt      840

gttgtcggtt atattggtga acgttgtcaa tatcgtgatt taaaatggtg ggaattacgt      900

gctagcctga aagacacccc ggctgttgtt tctgctgacg ctaaaaacgc tctgatcgct      960

ggtggtgttg acgctaccga cgctaacggt gctgaactgg ttaaaatgtc ttacaccgac     1020

aaaaacggta aaaccatcga aggtggttac gctctgaaag ctggtgacaa atactacgct     1080

gctgactacg acgaagctac cggtgctatc aaagctaaaa ccacctctta caccgctgct     1140

gacggtacca ccaaaaccgc tgctaaccag ctgggtggtg ttgacggtaa aaccgaagtt     1200

gttaccatcg acggtaaaac ctacaacgct tctaaagctg ctggtcacga cttcaaagct     1260

cagccggaac tggctgaagc tgctgctaaa accaccgaaa acccgctgca aaaaatcgac     1320

gctgctctgg ctcaggttga cgctctgcgt tctgacctgg gtgctgttca gaaccgtttc     1380

aactctgcta tcaccaacct gggtaacacc gttaacaacc tgtctgaagc tcgttctcgt     1440

atcgaagact ctgactacgc taccgaagtt tctaacatgt ctcgtgctca gatcctgcaa     1500

caggctggta cctctgttct ggctcaggct aaccaggttc cgcagaacgt tctgtctctg     1560

ctgcgttaa                                                             1569


<210>  6
<211>  565
<212>  PRT
<213>  Chimeric Sequence

<400>  6

Met Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
1               5                   10                  15      


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
            20                  25                  30          


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
        35                  40                  45              


Lys Trp Trp Glu Leu Arg Glu Ala Ala Ala Lys Pro Ala Gln Val Ile 
    50                  55                  60                  


Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn Asn Leu Asn Lys Ser 
65                  70                  75                  80  


Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu Ser Ser Gly Leu Arg 
                85                  90                  95      


Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg 
            100                 105                 110         


Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Asn 
        115                 120                 125             


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
    130                 135                 140                 


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val Gln Ser Ala Asn 
145                 150                 155                 160 


Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile Gln Ala Glu Ile Thr 
                165                 170                 175     


Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly Arg Thr Gln Phe Asn 
            180                 185                 190         


Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu Thr Ile Gln Val Gly 
        195                 200                 205             


Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Lys Gln Ile Asn Ser 
    210                 215                 220                 


Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln Lys Ala Tyr Asp Val 
225                 230                 235                 240 


Lys Asp Thr Ala Val Thr Thr Lys Ala Tyr Ala Asn Asn Gly Thr Thr 
                245                 250                 255     


Leu Asp Val Ser Gly Leu Asp Asp Ala Ala Ile Lys Ala Ala Thr Gly 
            260                 265                 270         


Gly Thr Asn Gly Thr Ala Ser Val Thr Gly Gly Ala Val Lys Phe Asp 
        275                 280                 285             


Ala Asp Asn Asn Lys Tyr Phe Val Thr Ile Gly Gly Phe Thr Gly Ala 
    290                 295                 300                 


Asp Ala Ala Lys Asn Gly Asp Tyr Glu Val Asn Val Ala Thr Asp Gly 
305                 310                 315                 320 


Thr Val Thr Leu Ala Ala Gly Ala Thr Lys Thr Thr Met Pro Ala Gly 
                325                 330                 335     


Ala Thr Thr Lys Thr Glu Val Gln Glu Leu Lys Asp Thr Pro Ala Val 
            340                 345                 350         


Val Ser Ala Asp Ala Lys Asn Ala Leu Ile Ala Gly Gly Val Asp Ala 
        355                 360                 365             


Thr Asp Ala Asn Gly Ala Glu Leu Val Lys Met Ser Tyr Thr Asp Lys 
    370                 375                 380                 


Asn Gly Lys Thr Ile Glu Gly Gly Tyr Ala Leu Lys Ala Gly Asp Lys 
385                 390                 395                 400 


Tyr Tyr Ala Ala Asp Tyr Asp Glu Ala Thr Gly Ala Ile Lys Ala Lys 
                405                 410                 415     


Thr Thr Ser Tyr Thr Ala Ala Asp Gly Thr Thr Lys Thr Ala Ala Asn 
            420                 425                 430         


Gln Leu Gly Gly Val Asp Gly Lys Thr Glu Val Val Thr Ile Asp Gly 
        435                 440                 445             


Lys Thr Tyr Asn Ala Ser Lys Ala Ala Gly His Asp Phe Lys Ala Gln 
    450                 455                 460                 


Pro Glu Leu Ala Glu Ala Ala Ala Lys Thr Thr Glu Asn Pro Leu Gln 
465                 470                 475                 480 


Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Ala Leu Arg Ser Asp Leu 
                485                 490                 495     


Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn 
            500                 505                 510         


Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg Ile Glu Asp Ser Asp 
        515                 520                 525             


Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala Gln Ile Leu Gln Gln 
    530                 535                 540                 


Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val 
545                 550                 555                 560 


Leu Ser Leu Leu Arg 
                565 


<210>  7
<211>  338
<212>  PRT
<213>  Chimeric Sequence

<400>  7

Met Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
1               5                   10                  15      


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
            20                  25                  30          


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
        35                  40                  45              


Lys Trp Trp Glu Leu Arg Glu Ala Ala Ala Lys Pro Ala Gln Val Ile 
    50                  55                  60                  


Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn Asn Leu Asn Lys Ser 
65                  70                  75                  80  


Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu Ser Ser Gly Leu Arg 
                85                  90                  95      


Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg 
            100                 105                 110         


Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Asn 
        115                 120                 125             


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
    130                 135                 140                 


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val Gln Ser Ala Asn 
145                 150                 155                 160 


Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile Gln Ala Glu Ile Thr 
                165                 170                 175     


Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly Arg Thr Gln Phe Asn 
            180                 185                 190         


Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu Thr Ile Gln Val Gly 
        195                 200                 205             


Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Lys Gln Ile Asn Ser 
    210                 215                 220                 


Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln Lys Ala Ser Glu Leu 
225                 230                 235                 240 


Ala Glu Ala Ala Ala Lys Thr Thr Glu Asn Pro Leu Gln Lys Ile Asp 
                245                 250                 255     


Ala Ala Leu Ala Gln Val Asp Ala Leu Arg Ser Asp Leu Gly Ala Val 
            260                 265                 270         


Gln Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Asn 
        275                 280                 285             


Asn Leu Ser Glu Ala Arg Ser Arg Ile Glu Asp Ser Asp Tyr Ala Thr 
    290                 295                 300                 


Glu Val Ser Asn Met Ser Arg Ala Gln Ile Leu Gln Gln Ala Gly Thr 
305                 310                 315                 320 


Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu 
                325                 330                 335     


Leu Arg 
        


<210>  8
<211>  466
<212>  PRT
<213>  Chimeric Sequence

<400>  8

Met Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
1               5                   10                  15      


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
            20                  25                  30          


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
        35                  40                  45              


Lys Trp Trp Glu Leu Arg Glu Ala Ala Ala Lys Pro Ala Gln Val Ile 
    50                  55                  60                  


Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn Asn Leu Asn Lys Ser 
65                  70                  75                  80  


Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu Ser Ser Gly Leu Arg 
                85                  90                  95      


Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg 
            100                 105                 110         


Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Asn 
        115                 120                 125             


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
    130                 135                 140                 


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val Gln Ser Ala Asn 
145                 150                 155                 160 


Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile Gln Ala Glu Ile Thr 
                165                 170                 175     


Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly Arg Thr Gln Phe Asn 
            180                 185                 190         


Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu Thr Ile Gln Val Gly 
        195                 200                 205             


Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Lys Gln Ile Asn Ser 
    210                 215                 220                 


Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln Lys Ala Tyr Asp Val 
225                 230                 235                 240 


Lys Asp Thr Ala Ala Ser Leu Lys Asp Thr Pro Ala Val Val Ser Ala 
                245                 250                 255     


Asp Ala Lys Asn Ala Leu Ile Ala Gly Gly Val Asp Ala Thr Asp Ala 
            260                 265                 270         


Asn Gly Ala Glu Leu Val Lys Met Ser Tyr Thr Asp Lys Asn Gly Lys 
        275                 280                 285             


Thr Ile Glu Gly Gly Tyr Ala Leu Lys Ala Gly Asp Lys Tyr Tyr Ala 
    290                 295                 300                 


Ala Asp Tyr Asp Glu Ala Thr Gly Ala Ile Lys Ala Lys Thr Thr Ser 
305                 310                 315                 320 


Tyr Thr Ala Ala Asp Gly Thr Thr Lys Thr Ala Ala Asn Gln Leu Gly 
                325                 330                 335     


Gly Val Asp Gly Lys Thr Glu Val Val Thr Ile Asp Gly Lys Thr Tyr 
            340                 345                 350         


Asn Ala Ser Lys Ala Ala Gly His Asp Phe Lys Ala Gln Pro Glu Leu 
        355                 360                 365             


Ala Glu Ala Ala Ala Lys Thr Thr Glu Asn Pro Leu Gln Lys Ile Asp 
    370                 375                 380                 


Ala Ala Leu Ala Gln Val Asp Ala Leu Arg Ser Asp Leu Gly Ala Val 
385                 390                 395                 400 


Gln Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Asn 
                405                 410                 415     


Asn Leu Ser Glu Ala Arg Ser Arg Ile Glu Asp Ser Asp Tyr Ala Thr 
            420                 425                 430         


Glu Val Ser Asn Met Ser Arg Ala Gln Ile Leu Gln Gln Ala Gly Thr 
        435                 440                 445             


Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu 
    450                 455                 460                 


Leu Arg 
465     


<210>  9
<211>  394
<212>  PRT
<213>  Chimeric Sequence

<400>  9

Met Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
1               5                   10                  15      


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
            20                  25                  30          


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
        35                  40                  45              


Lys Trp Trp Glu Leu Arg Glu Ala Ala Ala Lys Pro Ala Gln Val Ile 
    50                  55                  60                  


Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn Asn Leu Asn Lys Ser 
65                  70                  75                  80  


Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu Ser Ser Gly Leu Arg 
                85                  90                  95      


Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg 
            100                 105                 110         


Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Asn 
        115                 120                 125             


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
    130                 135                 140                 


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val Gln Ser Ala Asn 
145                 150                 155                 160 


Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile Gln Ala Glu Ile Thr 
                165                 170                 175     


Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly Arg Thr Gln Phe Asn 
            180                 185                 190         


Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu Thr Ile Gln Val Gly 
        195                 200                 205             


Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Lys Gln Ile Asn Ser 
    210                 215                 220                 


Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln Lys Ala Ser Met Asn 
225                 230                 235                 240 


Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp 
                245                 250                 255     


Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys 
            260                 265                 270         


Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp 
        275                 280                 285             


Trp Glu Leu Arg Ala Ser Glu Leu Ala Glu Ala Ala Ala Lys Thr Thr 
    290                 295                 300                 


Glu Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Ala 
305                 310                 315                 320 


Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
                325                 330                 335     


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg 
            340                 345                 350         


Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala 
        355                 360                 365             


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
    370                 375                 380                 


Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
385                 390                 


<210>  10
<211>  522
<212>  PRT
<213>  Chimeric Sequence

<400>  10

Met Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
1               5                   10                  15      


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
            20                  25                  30          


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
        35                  40                  45              


Lys Trp Trp Glu Leu Arg Glu Ala Ala Ala Lys Pro Ala Gln Val Ile 
    50                  55                  60                  


Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn Asn Leu Asn Lys Ser 
65                  70                  75                  80  


Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu Ser Ser Gly Leu Arg 
                85                  90                  95      


Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg 
            100                 105                 110         


Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Asn 
        115                 120                 125             


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
    130                 135                 140                 


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val Gln Ser Ala Asn 
145                 150                 155                 160 


Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile Gln Ala Glu Ile Thr 
                165                 170                 175     


Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly Arg Thr Gln Phe Asn 
            180                 185                 190         


Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu Thr Ile Gln Val Gly 
        195                 200                 205             


Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Lys Gln Ile Asn Ser 
    210                 215                 220                 


Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln Lys Ala Tyr Asp Val 
225                 230                 235                 240 


Lys Asp Thr Ala Ala Ser Met Asn Ser Asp Ser Glu Cys Pro Leu Ser 
                245                 250                 255     


His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala 
            260                 265                 270         


Leu Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg 
        275                 280                 285             


Cys Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Ala Ser Leu Lys 
    290                 295                 300                 


Asp Thr Pro Ala Val Val Ser Ala Asp Ala Lys Asn Ala Leu Ile Ala 
305                 310                 315                 320 


Gly Gly Val Asp Ala Thr Asp Ala Asn Gly Ala Glu Leu Val Lys Met 
                325                 330                 335     


Ser Tyr Thr Asp Lys Asn Gly Lys Thr Ile Glu Gly Gly Tyr Ala Leu 
            340                 345                 350         


Lys Ala Gly Asp Lys Tyr Tyr Ala Ala Asp Tyr Asp Glu Ala Thr Gly 
        355                 360                 365             


Ala Ile Lys Ala Lys Thr Thr Ser Tyr Thr Ala Ala Asp Gly Thr Thr 
    370                 375                 380                 


Lys Thr Ala Ala Asn Gln Leu Gly Gly Val Asp Gly Lys Thr Glu Val 
385                 390                 395                 400 


Val Thr Ile Asp Gly Lys Thr Tyr Asn Ala Ser Lys Ala Ala Gly His 
                405                 410                 415     


Asp Phe Lys Ala Gln Pro Glu Leu Ala Glu Ala Ala Ala Lys Thr Thr 
            420                 425                 430         


Glu Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Ala 
        435                 440                 445             


Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
    450                 455                 460                 


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg 
465                 470                 475                 480 


Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala 
                485                 490                 495     


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
            500                 505                 510         


Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
        515                 520         


<210>  11
<211>  1263
<212>  DNA
<213>  Chimeric Sequence

<400>  11
atgaattccg atagcgaatg tcctctaagt catgatggtt attgtttaca tgatggtgtt       60

tgtatgtata ttgaagcttt agataaatat gcttgtaatt gtgttgtcgg ttatattggt      120

gaacgttgtc aatatcgtga tttaaaatgg tgggaattac gtgaagctgc tgctaaaccg      180

atgcgtatca accacaacat cgctgctctg aacaccctga accgtctgtc ttctaacaac      240

tctgcttctc agaaaaacat ggaaaaactg tcttctggtc tgcgtatcaa ccgtgctggt      300

gacgacgctg ctggtctggc tatctctgaa aaaatgcgtg gtcagatccg tggtctggaa      360

atggcttcta aaaactctca ggacggtatc tctctgatcc agaccgctga aggtgctctg      420

accgaaaccc acgctatcct gcaacgtgtt cgtgaactgg ttgttcaggc tggtaacacc      480

ggtacccagg acaaagctac cgacctgcaa tctatccagg acgaaatctc tgctctgacc      540

gacgaaatcg acggtatctc taaccgtacc gaattcaacg gtaaaaaact gctggacggt      600

acctacaaag ttgacaccgc taccccggct aaccaaaaaa atctggtctt ccagatcggg      660

gctaacgcta cccagcagat ctctgttaac atcgaagaca tgggtgctga cgctctgggt      720

atcaaagaag ctgacggttc tatcgctgct ctgcactctg ttaacgacct ggacgttacc      780

aaattcgctg acaacgctgc tgacaccgct gacataggct tcgacgctca gctcaaagtt      840

gttgacgaag ctatcaacca ggtttcttct cagcgtgcta aactgggtgc tgttcagaac      900

cgtctggaac acaccatcaa caacctgtct gcttctggtg aaaacctgac cgctgctgaa      960

tctcgtatcc gtgacgttga catggctaaa gaaatgtctg aattcaccaa aaacaacatc     1020

ctgtctcagg cttctcaggc tatgctggct caggctaacc agcagccgca gaacgttctg     1080

caactgctgc gtgcggccgc aaattccgat agcgaatgtc ctctaagtca tgatggttat     1140

tgtttacatg atggtgtttg tatgtatatt gaagctttag ataaatatgc ttgtaattgt     1200

gttgtcggtt atattggtga acgttgtcaa tatcgtgatt taaaatggtg ggaattacgt     1260

taa                                                                   1263


<210>  12
<211>  1863
<212>  DNA
<213>  Chimeric Sequence

<400>  12
atgaattccg atagcgaatg tcctctaagt catgatggtt attgtttaca tgatggtgtt       60

tgtatgtata ttgaagcttt agataaatat gcttgtaatt gtgttgtcgg ttatattggt      120

gaacgttgtc aatatcgtga tttaaaatgg tgggaattac gtgaagctgc tgctaaaccg      180

gctcaggtta tcaacaccaa ctctctgtct ctgctgaccc agaacaacct gaacaaatct      240

cagtctgctc tgggtaccgc tatcgaacgt ctgtcttctg gtctgcgtat caactctgct      300

aaagacgacg ctgctggtca ggctatcgct aaccgtttca ccgctaacat caaaggtctg      360

acccaggctt ctcgtaacgc taacgacggt atctctatcg ctcagaccac cgaaggtgct      420

ctgaacgaaa tcaacaacaa cctgcaacgt gttcgtgaac tggctgttca gtctgctaac      480

tctaccaact ctcagtctga cctggactct atccaggctg aaatcaccca gcgtctgaac      540

gaaatcgacc gtgtttctgg tcgtacccag ttcaacggtg ttaaagttct ggctcaggac      600

aacaccctga ccatccaggt tggtgctaac gacggtgaaa ccatcgacat cgacctgaaa      660

cagatcaact ctcagaccct gggtctggac tctctgaacg ttcagaaagc ttacgacgtt      720

aaagacaccg ctgttaccac caaagcttac gctaacaacg gtaccaccct ggacgtttct      780

ggtctggacg acgctgctat caaagctgct accggtggta ccaacggtac cgcttctgtt      840

accggtggtg ctgttaaatt cgacgctgac aacaacaaat acttcgttac catcggtggt      900

ttcaccggtg ctgacgctgc taaaaacggt gactacgaag ttaacgttgc taccgacggt      960

accgttaccc tggctgctgg tgctaccaaa accaccatgc cggctggtgc taccaccaaa     1020

accgaagttc aggaactgaa agacaccccg gctgttgttt ctgctgacgc taaaaacgct     1080

ctgatcgctg gtggtgttga cgctaccgac gctaacggtg ctgaactggt taaaatgtct     1140

tacaccgaca aaaacggtaa aaccatcgaa ggtggttacg ctctgaaagc tggtgacaaa     1200

tactacgctg ctgactacga cgaagctacc ggtgctatca aagctaaaac cacctcttac     1260

accgctgctg acggtaccac caaaaccgct gctaaccagc tgggtggtgt tgacggtaaa     1320

accgaagttg ttaccatcga cggtaaaacc tacaacgctt ctaaagctgc tggtcacgac     1380

ttcaaagctc agccggaact ggctgaagct gctgctaaaa ccaccgaaaa cccgctgcaa     1440

aaaatcgacg ctgctctggc tcaggttgac gctctgcgtt ctgacctggg tgctgttcag     1500

aaccgtttca actctgctat caccaacctg ggtaacaccg ttaacaacct gtctgaagct     1560

cgttctcgta tcgaagactc tgactacgct accgaagttt ctaacatgtc tcgtgctcag     1620

atcctgcaac aggctggtac ctctgttctg gctcaggcta accaggttcc gcagaacgtt     1680

ctgtctctgc tgcgtgctag catgaattcc gatagcgaat gtcctctaag tcatgatggt     1740

tattgtttac atgatggtgt ttgtatgtat attgaagctt tagataaata tgcttgtaat     1800

tgtgttgtcg gttatattgg tgaacgttgt caatatcgtg atttaaaatg gtgggaatta     1860

cgt                                                                   1863


<210>  13
<211>  1518
<212>  DNA
<213>  Non-chimeric Sequence

<400>  13
atggctcagg ttatcaacac caactctctg tctctgctga cccagaacaa cctgaacaaa       60

tctcagtctg ctctgggtac cgctatcgaa cgtctgtctt ctggtctgcg tatcaactct      120

gctaaagacg acgctgctgg tcaggctatc gctaaccgtt tcaccgctaa catcaaaggt      180

ctgacccagg cttctcgtaa cgctaacgac ggtatctcta tcgctcagac caccgaaggt      240

gctctgaacg aaatcaacaa caacctgcaa cgtgttcgtg aactggctgt tcagtctgct      300

aactctacca actctcagtc tgacctggac tctatccagg ctgaaatcac ccagcgtctg      360

aacgaaatcg accgtgtttc tggtcgtacc cagttcaacg gtgttaaagt tctggctcag      420

gacaacaccc tgaccatcca ggttggtgct aacgacggtg aaaccatcga catcgacctg      480

aaacagatca actctcagac cctgggtctg gactctctga acgttcagaa agcttacgac      540

gttaaagaca ccgctgttac caccaaagct tacgctaaca acggtaccac cctggacgtt      600

tctggtctgg acgacgctgc tatcaaagct gctaccggtg gtaccaacgg taccgcttct      660

gttaccggtg gtgctgttaa attcgacgct gacaacaaca aatacttcgt taccatcggt      720

ggtttcaccg gtgctgacgc tgctaaaaac ggtgactacg aagttaacgt tgctaccgac      780

ggtaccgtta ccctggctgc tggtgctacc aaaaccacca tgccggctgg tgctaccacc      840

aaaaccgaag ttcaggaact gaaagacacc ccggctgttg tttctgctga cgctaaaaac      900

gctctgatcg ctggtggtgt tgacgctacc gacgctaacg gtgctgaact ggttaaaatg      960

tcttacaccg acaaaaacgg taaaaccatc gaaggtggtt acgctctgaa agctggtgac     1020

aaatactacg ctgctgacta cgacgaagct accggtgcta tcaaagctaa aaccacctct     1080

tacaccgctg ctgacggtac caccaaaacc gctgctaacc agctgggtgg tgttgacggt     1140

aaaaccgaag ttgttaccat cgacggtaaa acctacaacg cttctaaagc tgctggtcac     1200

gacttcaaag ctcagccgga actggctgaa gctgctgcta aaaccaccga aaacccgctg     1260

caaaaaatcg acgctgctct ggctcaggtt gacgctctgc gttctgacct gggtgctgtt     1320

cagaaccgtt tcaactctgc tatcaccaac ctgggtaaca ccgttaacaa cctgtctgaa     1380

gctcgttctc gtatcgaaga ctctgactac gctaccgaag tttctaacat gtctcgtgct     1440

cagatcctgc aacaggctgg tacctctgtt ctggctcagg ctaaccaggt tccgcagaac     1500

gttctgtctc tgctgcgt                                                   1518


<210>  14
<211>  840
<212>  DNA
<213>  Non-chimeric Sequence

<400>  14
atggctcagg ttatcaacac caactctctg tctctgctga cccagaacaa cctgaacaaa       60

tctcagtctg ctctgggtac cgctatcgaa cgtctgtctt ctggtctgcg tatcaactct      120

gctaaagacg acgctgctgg tcaggctatc gctaaccgtt tcaccgctaa catcaaaggt      180

ctgacccagg cttctcgtaa cgctaacgac ggtatctcta tcgctcagac caccgaaggt      240

gctctgaacg aaatcaacaa caacctgcaa cgtgttcgtg aactggctgt tcagtctgct      300

aactctacca actctcagtc tgacctggac tctatccagg ctgaaatcac ccagcgtctg      360

aacgaaatcg accgtgtttc tggtcgtacc cagttcaacg gtgttaaagt tctggctcag      420

gacaacaccc tgaccatcca ggttggtgct aacgacggtg aaaccatcga catcgacctg      480

aaacagatca actctcagac cctgggtctg gactctctga acgttcagaa agctagcgaa      540

ctggctgaag ctgctgctaa aaccaccgaa aacccgctgc aaaaaatcga cgctgctctg      600

gctcaggttg acgctctgcg ttctgacctg ggtgctgttc agaaccgttt caactctgct      660

atcaccaacc tgggtaacac cgttaacaac ctgtctgaag ctcgttctcg tatcgaagac      720

tctgactacg ctaccgaagt ttctaacatg tctcgtgctc agatcctgca acaggctggt      780

acctctgttc tggctcaggc taaccaggtt ccgcagaacg ttctgtctct gctgcgttaa      840


<210>  15
<211>  162
<212>  DNA
<213>  Non-chimeric Sequence

<400>  15
atgaattccg atagcgaatg tcctctaagt catgatggtt attgtttaca tgatggtgtt       60

tgtatgtata ttgaagcttt agataaatat gcttgtaatt gtgttgtcgg ttatattggt      120

gaacgttgtc aatatcgtga tttaaaatgg tgggaattac gt                         162


<210>  16
<211>  420
<212>  PRT
<213>  Chimeric Sequence

<400>  16

Met Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
1               5                   10                  15      


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
            20                  25                  30          


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
        35                  40                  45              


Lys Trp Trp Glu Leu Arg Glu Ala Ala Ala Lys Pro Met Arg Ile Asn 
    50                  55                  60                  


His Asn Ile Ala Ala Leu Asn Thr Leu Asn Arg Leu Ser Ser Asn Asn 
65                  70                  75                  80  


Ser Ala Ser Gln Lys Asn Met Glu Lys Leu Ser Ser Gly Leu Arg Ile 
                85                  90                  95      


Asn Arg Ala Gly Asp Asp Ala Ala Gly Leu Ala Ile Ser Glu Lys Met 
            100                 105                 110         


Arg Gly Gln Ile Arg Gly Leu Glu Met Ala Ser Lys Asn Ser Gln Asp 
        115                 120                 125             


Gly Ile Ser Leu Ile Gln Thr Ala Glu Gly Ala Leu Thr Glu Thr His 
    130                 135                 140                 


Ala Ile Leu Gln Arg Val Arg Glu Leu Val Val Gln Ala Gly Asn Thr 
145                 150                 155                 160 


Gly Thr Gln Asp Lys Ala Thr Asp Leu Gln Ser Ile Gln Asp Glu Ile 
                165                 170                 175     


Ser Ala Leu Thr Asp Glu Ile Asp Gly Ile Ser Asn Arg Thr Glu Phe 
            180                 185                 190         


Asn Gly Lys Lys Leu Leu Asp Gly Thr Tyr Lys Val Asp Thr Ala Thr 
        195                 200                 205             


Pro Ala Asn Gln Lys Asn Leu Val Phe Gln Ile Gly Ala Asn Ala Thr 
    210                 215                 220                 


Gln Gln Ile Ser Val Asn Ile Glu Asp Met Gly Ala Asp Ala Leu Gly 
225                 230                 235                 240 


Ile Lys Glu Ala Asp Gly Ser Ile Ala Ala Leu His Ser Val Asn Asp 
                245                 250                 255     


Leu Asp Val Thr Lys Phe Ala Asp Asn Ala Ala Asp Thr Ala Asp Ile 
            260                 265                 270         


Gly Phe Asp Ala Gln Leu Lys Val Val Asp Glu Ala Ile Asn Gln Val 
        275                 280                 285             


Ser Ser Gln Arg Ala Lys Leu Gly Ala Val Gln Asn Arg Leu Glu His 
    290                 295                 300                 


Thr Ile Asn Asn Leu Ser Ala Ser Gly Glu Asn Leu Thr Ala Ala Glu 
305                 310                 315                 320 


Ser Arg Ile Arg Asp Val Asp Met Ala Lys Glu Met Ser Glu Phe Thr 
                325                 330                 335     


Lys Asn Asn Ile Leu Ser Gln Ala Ser Gln Ala Met Leu Ala Gln Ala 
            340                 345                 350         


Asn Gln Gln Pro Gln Asn Val Leu Gln Leu Leu Arg Ala Ala Ala Asn 
        355                 360                 365             


Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp 
    370                 375                 380                 


Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys 
385                 390                 395                 400 


Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp 
                405                 410                 415     


Trp Glu Leu Arg 
            420 


<210>  17
<211>  621
<212>  PRT
<213>  Chimeric Sequence

<400>  17

Met Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
1               5                   10                  15      


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
            20                  25                  30          


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
        35                  40                  45              


Lys Trp Trp Glu Leu Arg Glu Ala Ala Ala Lys Pro Ala Gln Val Ile 
    50                  55                  60                  


Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn Asn Leu Asn Lys Ser 
65                  70                  75                  80  


Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu Ser Ser Gly Leu Arg 
                85                  90                  95      


Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg 
            100                 105                 110         


Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Asn 
        115                 120                 125             


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
    130                 135                 140                 


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val Gln Ser Ala Asn 
145                 150                 155                 160 


Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile Gln Ala Glu Ile Thr 
                165                 170                 175     


Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly Arg Thr Gln Phe Asn 
            180                 185                 190         


Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu Thr Ile Gln Val Gly 
        195                 200                 205             


Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Lys Gln Ile Asn Ser 
    210                 215                 220                 


Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln Lys Ala Tyr Asp Val 
225                 230                 235                 240 


Lys Asp Thr Ala Val Thr Thr Lys Ala Tyr Ala Asn Asn Gly Thr Thr 
                245                 250                 255     


Leu Asp Val Ser Gly Leu Asp Asp Ala Ala Ile Lys Ala Ala Thr Gly 
            260                 265                 270         


Gly Thr Asn Gly Thr Ala Ser Val Thr Gly Gly Ala Val Lys Phe Asp 
        275                 280                 285             


Ala Asp Asn Asn Lys Tyr Phe Val Thr Ile Gly Gly Phe Thr Gly Ala 
    290                 295                 300                 


Asp Ala Ala Lys Asn Gly Asp Tyr Glu Val Asn Val Ala Thr Asp Gly 
305                 310                 315                 320 


Thr Val Thr Leu Ala Ala Gly Ala Thr Lys Thr Thr Met Pro Ala Gly 
                325                 330                 335     


Ala Thr Thr Lys Thr Glu Val Gln Glu Leu Lys Asp Thr Pro Ala Val 
            340                 345                 350         


Val Ser Ala Asp Ala Lys Asn Ala Leu Ile Ala Gly Gly Val Asp Ala 
        355                 360                 365             


Thr Asp Ala Asn Gly Ala Glu Leu Val Lys Met Ser Tyr Thr Asp Lys 
    370                 375                 380                 


Asn Gly Lys Thr Ile Glu Gly Gly Tyr Ala Leu Lys Ala Gly Asp Lys 
385                 390                 395                 400 


Tyr Tyr Ala Ala Asp Tyr Asp Glu Ala Thr Gly Ala Ile Lys Ala Lys 
                405                 410                 415     


Thr Thr Ser Tyr Thr Ala Ala Asp Gly Thr Thr Lys Thr Ala Ala Asn 
            420                 425                 430         


Gln Leu Gly Gly Val Asp Gly Lys Thr Glu Val Val Thr Ile Asp Gly 
        435                 440                 445             


Lys Thr Tyr Asn Ala Ser Lys Ala Ala Gly His Asp Phe Lys Ala Gln 
    450                 455                 460                 


Pro Glu Leu Ala Glu Ala Ala Ala Lys Thr Thr Glu Asn Pro Leu Gln 
465                 470                 475                 480 


Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Ala Leu Arg Ser Asp Leu 
                485                 490                 495     


Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn 
            500                 505                 510         


Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg Ile Glu Asp Ser Asp 
        515                 520                 525             


Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala Gln Ile Leu Gln Gln 
    530                 535                 540                 


Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val 
545                 550                 555                 560 


Leu Ser Leu Leu Arg Ala Ser Met Asn Ser Asp Ser Glu Cys Pro Leu 
                565                 570                 575     


Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu 
            580                 585                 590         


Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu 
        595                 600                 605             


Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg 
    610                 615                 620     


<210>  18
<211>  506
<212>  PRT
<213>  Non-chimeric Sequence

<400>  18

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala 
                85                  90                  95      


Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile 
            100                 105                 110         


Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly 
        115                 120                 125             


Arg Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu 
    130                 135                 140                 


Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu 
145                 150                 155                 160 


Lys Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln 
                165                 170                 175     


Lys Ala Tyr Asp Val Lys Asp Thr Ala Val Thr Thr Lys Ala Tyr Ala 
            180                 185                 190         


Asn Asn Gly Thr Thr Leu Asp Val Ser Gly Leu Asp Asp Ala Ala Ile 
        195                 200                 205             


Lys Ala Ala Thr Gly Gly Thr Asn Gly Thr Ala Ser Val Thr Gly Gly 
    210                 215                 220                 


Ala Val Lys Phe Asp Ala Asp Asn Asn Lys Tyr Phe Val Thr Ile Gly 
225                 230                 235                 240 


Gly Phe Thr Gly Ala Asp Ala Ala Lys Asn Gly Asp Tyr Glu Val Asn 
                245                 250                 255     


Val Ala Thr Asp Gly Thr Val Thr Leu Ala Ala Gly Ala Thr Lys Thr 
            260                 265                 270         


Thr Met Pro Ala Gly Ala Thr Thr Lys Thr Glu Val Gln Glu Leu Lys 
        275                 280                 285             


Asp Thr Pro Ala Val Val Ser Ala Asp Ala Lys Asn Ala Leu Ile Ala 
    290                 295                 300                 


Gly Gly Val Asp Ala Thr Asp Ala Asn Gly Ala Glu Leu Val Lys Met 
305                 310                 315                 320 


Ser Tyr Thr Asp Lys Asn Gly Lys Thr Ile Glu Gly Gly Tyr Ala Leu 
                325                 330                 335     


Lys Ala Gly Asp Lys Tyr Tyr Ala Ala Asp Tyr Asp Glu Ala Thr Gly 
            340                 345                 350         


Ala Ile Lys Ala Lys Thr Thr Ser Tyr Thr Ala Ala Asp Gly Thr Thr 
        355                 360                 365             


Lys Thr Ala Ala Asn Gln Leu Gly Gly Val Asp Gly Lys Thr Glu Val 
    370                 375                 380                 


Val Thr Ile Asp Gly Lys Thr Tyr Asn Ala Ser Lys Ala Ala Gly His 
385                 390                 395                 400 


Asp Phe Lys Ala Gln Pro Glu Leu Ala Glu Ala Ala Ala Lys Thr Thr 
                405                 410                 415     


Glu Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Ala 
            420                 425                 430         


Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
        435                 440                 445             


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg 
    450                 455                 460                 


Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala 
465                 470                 475                 480 


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
                485                 490                 495     


Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
            500                 505     


<210>  19
<211>  279
<212>  PRT
<213>  Non-chimeric Sequence

<400>  19

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala 
                85                  90                  95      


Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile 
            100                 105                 110         


Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly 
        115                 120                 125             


Arg Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu 
    130                 135                 140                 


Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu 
145                 150                 155                 160 


Lys Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln 
                165                 170                 175     


Lys Ala Ser Glu Leu Ala Glu Ala Ala Ala Lys Thr Thr Glu Asn Pro 
            180                 185                 190         


Leu Gln Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Ala Leu Arg Ser 
        195                 200                 205             


Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu 
    210                 215                 220                 


Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg Ile Glu Asp 
225                 230                 235                 240 


Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala Gln Ile Leu 
                245                 250                 255     


Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln 
            260                 265                 270         


Asn Val Leu Ser Leu Leu Arg 
        275                 


<210>  20
<211>  54
<212>  PRT
<213>  Non-chimeric Sequence

<400>  20

Met Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
1               5                   10                  15      


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
            20                  25                  30          


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
        35                  40                  45              


Lys Trp Trp Glu Leu Arg 
    50                  


