                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Use Of IRE1alpha-XBP1 Signaling Pathway Biomarkers For Modulating
       Immune Responses

<130>  DFS-26725

<140>  PCT/US2019/060749
<141>  2019-11-11

<150>  US 62/769,265
<151>  2018-11-19

<150>  US 62/800,706
<151>  2019-02-04

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  7910
<212>  DNA
<213>  Homo sapiens

<400>  1
tgcctagtca gttctgcgtc cgctgaggct cggtcaccgc ctcgctgtcg tcgcggcgcc       60

cccgccccgt cctctgtccg taccgccccc ggagccaggg ccgagtcctc gccatgccgg      120

cccggcggct gctgctgctg ctgacgctgc tgctgcccgg cctcgggatt tttggaagta      180

ccagcacagt gacgcttcct gaaaccttgt tgtttgtgtc aacgctggat ggaagtttgc      240

atgctgtcag caagaggaca ggctcaatca aatggacttt aaaagaagat ccagtcctgc      300

aggtcccaac acatgtggaa gagcctgcct ttctcccaga tcctaatgat ggcagcctgt      360

atacgcttgg aagcaagaat aatgaaggcc tgacgaaact tccttttacc atcccagaat      420

tggtgcaggc atccccatgc cgaagttcag atggaatcct ctacatgggt aaaaagcagg      480

acatctggta tgttattgac ctcctgaccg gagagaagca gcagactttg tcatcggcct      540

ttgcagatag tctctgccca tcaacctctc ttctgtatct tgggcgaaca gaatacacca      600

tcaccatgta cgacaccaaa acccgagagc tccggtggaa tgccacctac tttgactatg      660

cggcctcact gcctgaggac gacgtggact acaagatgtc ccactttgtg tccaatggtg      720

atgggctggt ggtgactgtg gacagtgaat ctggggacgt cctgtggatc caaaactacg      780

cctcccctgt ggtggccttt tatgtctggc agcgggaggg tctgaggaag gtgatgcaca      840

tcaatgtcgc tgtggagacc ctgcgctatc tgaccttcat gtctggggag gtggggcgca      900

tcacaaagtg gaagtacccg ttccccaagg agacagaggc caagagcaag ctgacgccca      960

ctctgtatgt tgggaaatac tctaccagcc tctatgcctc tccctcaatg gtacacgagg     1020

gggttgctgt cgtgccccgc ggcagcacac ttcctttgct ggaagggccc cagactgatg     1080

gcgtcaccat tggggacaag ggggagtgtg tgatcacgcc cagcacggac gtcaagtttg     1140

atcccggact caaaagcaag aacaagctca actacttgag gaattactgg cttctgatag     1200

gacaccatga aaccccactg tctgcgtcta ccaagatgct ggagagattt cccaacaatc     1260

tacccaaaca tcgggaaaat gtgattcctg ctgattcaga gaaaaagagc tttgaggaag     1320

ttatcaacct ggttgaccag acttcagaaa acgcacctac caccgtgtct cgggatgtgg     1380

aggagaagcc cgcccatgcc cctgcccggc ccgaggcccc cgtggactcc atgcttaagg     1440

acatggctac catcatcctg agcaccttcc tgctgattgg ctgggtggcc ttcatcatca     1500

cctatcccct gagcatgcat cagcagcagc agctccagca ccagcagttc cagaaggaac     1560

tggagaagat ccagctcctg cagcagcagc agcagcagct gcccttccac ccacctggag     1620

acacggctca ggacggcgag ctcctggaca cgtctggccc gtactcagag agctcgggca     1680

ccagcagccc cagcacgtcc cccagggcct ccaaccactc gctctgctcc ggcagctctg     1740

cctccaaggc tggcagcagc ccctccctgg aacaagacga tggagatgag gaaaccagcg     1800

tggtgatagt tgggaaaatt tccttctgtc ccaaggatgt cctgggccat ggagctgagg     1860

gcacaattgt gtaccggggc atgtttgaca accgcgacgt ggccgtgaag aggatcctcc     1920

ccgagtgttt tagcttcgca gaccgtgagg tccagctgtt gcgagaatcg gatgagcacc     1980

cgaacgtgat ccgctacttc tgcacggaga aggaccggca attccagtac attgccatcg     2040

agctgtgtgc agccaccctg caagagtatg tggagcagaa ggactttgcg catctcggcc     2100

tggagcccat caccttgctg cagcagacca cctcgggcct ggcccacctc cactccctca     2160

acatcgttca cagagaccta aagccacaca acatcctcat atccatgccc aatgcacacg     2220

gcaagatcaa ggccatgatc tccgactttg gcctctgcaa gaagctggca gtgggcagac     2280

acagtttcag ccgccgatct ggggtgcctg gcacagaagg ctggatcgct ccagagatgc     2340

tgagcgaaga ctgtaaggag aaccctacct acacggtgga catcttttct gcaggctgcg     2400

tcttttacta cgtaatctct gagggcagcc acccttttgg caagtccctg cagcggcagg     2460

ccaacatcct cctgggtgcc tgcagccttg actgcttgca cccagagaag cacgaagacg     2520

tcattgcacg tgaattgata gagaagatga ttgcgatgga tcctcagaaa cgcccctcag     2580

cgaagcatgt gctcaaacac ccgttcttct ggagcctaga gaagcagctc cagttcttcc     2640

aggacgtgag cgacagaata gaaaaggaat ccctggatgg cccgatcgtg aagcagttag     2700

agagaggcgg gagagccgtg gtgaagatgg actggcggga gaacatcact gtccccctcc     2760

agacagacct gcgtaaattc aggacctata aaggtggttc tgtcagagat ctcctccgag     2820

ccatgagaaa taagaagcac cactaccggg agctgcctgc agaggtgcgg gagacgctgg     2880

ggtccctccc cgacgacttc gtgtgctact tcacatctcg cttcccccac ctcctcgcac     2940

acacctaccg ggccatggag ctgtgcagcc acgagagact cttccagccc tactacttcc     3000

acgagccccc agagccccag cccccagtga ctccagacgc cctctgagcg agggcggccc     3060

ctctgttctg gtggccccag ctgtgactga gggcctggtc accacaatta gagcttgatg     3120

cctcccggct ttgcagggag accaggcttc ccaaaccaag tgccttgagc tgcctgctct     3180

gcagcccaca gaggacagtg ctgaccccag gaagtgggag aagtggcccc tcgtgaccta     3240

cagggaactg ggaagatgct ggccccaaaa gccttacggt catgatgtct gcaaaggagg     3300

gcctcagaga cagcgcgagt agcaccccca gccatctact ggataaactt gcttcagact     3360

ttttaaattc ctgcttaatg tcagtctaca ggcctttcag gaagggagag gagggaatcg     3420

tacattttgc ttgcgtgctg ggacagctag gctgagatgc accaagtaca gccttcactg     3480

gagaccggaa ttgagaggtg ggggatgctg aggaggggga ggacggagtt cagagggtgt     3540

cgtcctgcag tgtgagattt ctcattgatc acagatgtgc ccagagtagc ccaggtcact     3600

gttaactagt gtttctgcag aggcagcagg agccatgagc atgaggtgtg gcattaggga     3660

ctggtcagct atgcatgctg gcaggtgggg ttgtgtctgc aggtctcaga aatgaagagg     3720

ctgctctgtt ctggaggcag ccgtggccca gtgccagtgg ccagaacagt ggcctttggt     3780

gggtgtgtcc cgggccatct cggggtggtg ctcaggagcg cctggggcaa gaggtaaaga     3840

gttccctggc cttcaaggag agcagcgaag acccagacag gggccagcct tcaggaccag     3900

agggaggccg ccgaatggga ccctcctggt caccaggaga aagccctggg ccagcgagta     3960

ggcagtcaaa ctccttcgtc cccaaggccg gtggaacaag aggctcgtgg tgagtcaggg     4020

ccagggtggg tggccaaggc cagggtcacc gtgtgcttca tgggccagct tttttgtttt     4080

tcttggcaaa ttttaataac tatattttga ttatactgta gaatgctatg tcagcataag     4140

taagctaaac ttgaagcttt cttgtgaaga ataaatgcaa gatagaatac atcttctatt     4200

ttttgtggta ccaaaaatca ccatcccctc aagagtgttc atgtatagaa cattctctaa     4260

tgctgaagag taaaacatta tagcaacact atgtaaatgt attgaacagt atcaaagaaa     4320

tagtctctaa attgtttgta ccatattttt ttttctaaac ttaacataat ttttagcttt     4380

agtttcagtc aaaactttgt cttttctctc ccgagagcct tagaggttaa aatgcaatca     4440

gcctaccgtg taaggagatg ttgtccatgt actttctcca gccagttggg ggatcattgc     4500

agctcaggcc tggtgaactc agagattcca ttcagtatta agaatgggat tgttgaattt     4560

tactcacaga gaaatcactg tttcttcatg ttgtaagatg ttttctgttt gtgtatttgt     4620

atcatggtta ctcatcaaaa gctctcattc tgcctttgta gaattcagtt cccttccttt     4680

catcatagct aaagtgactt ttttccctac tattaacgtg atcctacatc cttaaatctc     4740

atcgattacc tcacttaggc cttggaacct tggcccttgg tcggtgtcct tggcgtcttc     4800

taagcaaggc tgtgcgttgt tcagaaacgt ggccagaccg catttcctgc tgctcccatg     4860

ccgcatgcca ggtggcctga gacagagctc cccatacggc tgcaaggtgc tttacctgtg     4920

ggctttggca gtaacccaag agaggatcag aaggtggaga aggtgccacg agtgatttaa     4980

caggcctgcc acagggagtg cccccagccc agctcgttct cagcacaggt tttctctttg     5040

ggagtaccca ggtgatttct agtgacccaa ttttgtgtca tctccctgtt ttagccccac     5100

ttgcctagag acaactgttt ccgatgcctt ttctgcttat catactagtt tctaaccacg     5160

cagatttctc aaaatcattt attcaatgta ttttatttga gcacttagtg tattgagcta     5220

ggcaggatat agggtgccgg agatacagcg atgaacaaga caggcaaaac ttctgctttc     5280

ctaaaacttg tgatgagaga gaacaataaa aaagtgttgc tgccacaaag aaaccaaagt     5340

gtgtggggaa gggcgcgtgt ttgcggttta catctcttct gtcccagaat cacagggatc     5400

tggtccggtc acctctggtc tttcctctta gtcgccttta ggagccctgg ttcccgtcca     5460

tcctctgggg ggtttgtttg aagagatctc gtgtgggtac ttgtcatgaa aacaccttgg     5520

gcatcatctg gtgtatccag ttctagtctc gagaattctg gtttcccact gtgctcagca     5580

agtggaaagt tcttttcagg ccagaacagc tctgcaccat cacatatcgt gttgcggctt     5640

agctgtttgg tctgtagttc aggttatggg acttctccaa tcctggaagg ctgttgagct     5700

ttttagaagt actgtacgct atcttcaaga tggagcttgg tcacatctgt taggaatcca     5760

aaggacacta tgacttattt aaatcttgtc ttactaaacc tctcttgggc acgtgtgcca     5820

gaatttctct tgttgcttct tgagtctttt taatttcagt gttttttcgt ttgttttttg     5880

tttttttgag acagagtctc gctctgtcac ccaggctgga gtgcagtggc acgacctcag     5940

ctcactgcaa cctccgcctc cttggttcaa gcaattctcc tgcctcagcc tcccgagtag     6000

ctgggattac aggtgtgtgc caccacgctc ggctaatttt ttatattttt tttagtagag     6060

acggggtttc cccatgttag gcaggatggt ctcgatctcc taacctcgtg atccgcctgc     6120

ctcagcctcc caaagtgctg ggattacagg cttgagccac cgcacccggc ctaatctcag     6180

tttttgaagt gctccacaag tcattaggca ccaaaacatt ttcacctggg gaacactggc     6240

atttccctga ttagctgtga agcaatctag tggctaagtg tgaaatcctg ggtgcgcagg     6300

tgttctcact cccgccgtgt tctcagtgca gtggtggtca gaggcccttc caaggagaca     6360

tcactctgat cagttacaga tagatgttct ggaagatctg caggtgagta gatccagcag     6420

agtttcttcc caccaactct agaagaaagg gccttatcag agttgaccct gagcctttgg     6480

taaggttttg tgtgcatgcg attcagttat ctttggcaat tcttttcttg ctgcagtgag     6540

agattaattg gttgctgatc aaaccgttca tgcagatggg gggacctttg gattgtacgg     6600

ctttctcctc ttggctgctt tcttttcagg aagttggact ttggccaggt ttggctttcc     6660

cagagccgtt cctttctctg tcctttcctt gggtcctcat ggtgtgccca ttggatcctt     6720

ggccttgtga tcctctggga actgggggcc agttccactt ttgcagcctt ctgtgctgga     6780

agagaagccc agcgccctgg aaggagcctc tttaagtccc ccatgtcgct ttctctctct     6840

gctcttttag tgtctgagat tgcctttctt tgaatttccc agtgtttctt ttccttgtcc     6900

cttccctcac caacctggag ttattttggt tgactatgtc ctggctttgg cttctcctgg     6960

caggaagtca tcaggcatcc tctccaggtg agccgaaatt ccaccctccc aggttggaca     7020

tcatctttta aacccaatgg tctactcccc tccttcttta tgaaacagtg atttcccgtg     7080

agtaactctg gttctgattt tttgtaccgg cgcttaaatt ctttctgtag acgttggaaa     7140

gccacaaaga acgtgactgc agtgagcctc ccactggagc agccttaacc aacactttgg     7200

ccaaagcccc cccacctccc ctgtgtactg tgtgtgtgtt tggtggatac agtattcctt     7260

ttcagtgtcc ctaaagctgt gatggggagt ccccacttac ctagaaagca ttaccagtca     7320

cctactctgc attctcagat gtaaaccttg tgtagtgttc tttttgcaat gacctattta     7380

tttaacctat ttatatttat ttaattttta ctctgaaatg tatccagtta caattgtact     7440

tgcttaaagc acatcagatt tgttttggac aacacccttg accattttaa aactggaaaa     7500

gtgatactgt atccttccat gggatggatg ctttacagta gtcttattat taaagggtga     7560

ttaatttggt cggggtaaaa tgttaatttt taggtgattt ttaagaattc tgtgccatta     7620

tgtcttctgt gtggatggtt aattgtttaa ttagtacgtg ttaattgtgt gatacagtct     7680

tctttgtgga acccaaaatc ctctttttag ctttatattt tataaactgc cagattgtac     7740

aacttttatg tgcattttta aagcttgaag acatgagggt cattatctaa gttaaacagc     7800

ctatttttgt gcctcctgta cagttttata attctgctga tggcggcatc ttatgtcgag     7860

ccaaccacaa taaaggtagt tttagatttt ggaaaaaaaa aaaaaaaaaa                7910


<210>  2
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ala Arg Arg Leu Leu Leu Leu Leu Thr Leu Leu Leu Pro Gly 
1               5                   10                  15      


Leu Gly Ile Phe Gly Ser Thr Ser Thr Val Thr Leu Pro Glu Thr Leu 
            20                  25                  30          


Leu Phe Val Ser Thr Leu Asp Gly Ser Leu His Ala Val Ser Lys Arg 
        35                  40                  45              


Thr Gly Ser Ile Lys Trp Thr Leu Lys Glu Asp Pro Val Leu Gln Val 
    50                  55                  60                  


Pro Thr His Val Glu Glu Pro Ala Phe Leu Pro Asp Pro Asn Asp Gly 
65                  70                  75                  80  


Ser Leu Tyr Thr Leu Gly Ser Lys Asn Asn Glu Gly Leu Thr Lys Leu 
                85                  90                  95      


Pro Phe Thr Ile Pro Glu Leu Val Gln Ala Ser Pro Cys Arg Ser Ser 
            100                 105                 110         


Asp Gly Ile Leu Tyr Met Gly Lys Lys Gln Asp Ile Trp Tyr Val Ile 
        115                 120                 125             


Asp Leu Leu Thr Gly Glu Lys Gln Gln Thr Leu Ser Ser Ala Phe Ala 
    130                 135                 140                 


Asp Ser Leu Cys Pro Ser Thr Ser Leu Leu Tyr Leu Gly Arg Thr Glu 
145                 150                 155                 160 


Tyr Thr Ile Thr Met Tyr Asp Thr Lys Thr Arg Glu Leu Arg Trp Asn 
                165                 170                 175     


Ala Thr Tyr Phe Asp Tyr Ala Ala Ser Leu Pro Glu Asp Asp Val Asp 
            180                 185                 190         


Tyr Lys Met Ser His Phe Val Ser Asn Gly Asp Gly Leu Val Val Thr 
        195                 200                 205             


Val Asp Ser Glu Ser Gly Asp Val Leu Trp Ile Gln Asn Tyr Ala Ser 
    210                 215                 220                 


Pro Val Val Ala Phe Tyr Val Trp Gln Arg Glu Gly Leu Arg Lys Val 
225                 230                 235                 240 


Met His Ile Asn Val Ala Val Glu Thr Leu Arg Tyr Leu Thr Phe Met 
                245                 250                 255     


Ser Gly Glu Val Gly Arg Ile Thr Lys Trp Lys Tyr Pro Phe Pro Lys 
            260                 265                 270         


Glu Thr Glu Ala Lys Ser Lys Leu Thr Pro Thr Leu Tyr Val Gly Lys 
        275                 280                 285             


Tyr Ser Thr Ser Leu Tyr Ala Ser Pro Ser Met Val His Glu Gly Val 
    290                 295                 300                 


Ala Val Val Pro Arg Gly Ser Thr Leu Pro Leu Leu Glu Gly Pro Gln 
305                 310                 315                 320 


Thr Asp Gly Val Thr Ile Gly Asp Lys Gly Glu Cys Val Ile Thr Pro 
                325                 330                 335     


Ser Thr Asp Val Lys Phe Asp Pro Gly Leu Lys Ser Lys Asn Lys Leu 
            340                 345                 350         


Asn Tyr Leu Arg Asn Tyr Trp Leu Leu Ile Gly His His Glu Thr Pro 
        355                 360                 365             


Leu Ser Ala Ser Thr Lys Met Leu Glu Arg Phe Pro Asn Asn Leu Pro 
    370                 375                 380                 


Lys His Arg Glu Asn Val Ile Pro Ala Asp Ser Glu Lys Lys Ser Phe 
385                 390                 395                 400 


Glu Glu Val Ile Asn Leu Val Asp Gln Thr Ser Glu Asn Ala Pro Thr 
                405                 410                 415     


Thr Val Ser Arg Asp Val Glu Glu Lys Pro Ala His Ala Pro Ala Arg 
            420                 425                 430         


Pro Glu Ala Pro Val Asp Ser Met Leu Lys Asp Met Ala Thr Ile Ile 
        435                 440                 445             


Leu Ser Thr Phe Leu Leu Ile Gly Trp Val Ala Phe Ile Ile Thr Tyr 
    450                 455                 460                 


Pro Leu Ser Met His Gln Gln Gln Gln Leu Gln His Gln Gln Phe Gln 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Ile Gln Leu Leu Gln Gln Gln Gln Gln Gln Leu 
                485                 490                 495     


Pro Phe His Pro Pro Gly Asp Thr Ala Gln Asp Gly Glu Leu Leu Asp 
            500                 505                 510         


Thr Ser Gly Pro Tyr Ser Glu Ser Ser Gly Thr Ser Ser Pro Ser Thr 
        515                 520                 525             


Ser Pro Arg Ala Ser Asn His Ser Leu Cys Ser Gly Ser Ser Ala Ser 
    530                 535                 540                 


Lys Ala Gly Ser Ser Pro Ser Leu Glu Gln Asp Asp Gly Asp Glu Glu 
545                 550                 555                 560 


Thr Ser Val Val Ile Val Gly Lys Ile Ser Phe Cys Pro Lys Asp Val 
                565                 570                 575     


Leu Gly His Gly Ala Glu Gly Thr Ile Val Tyr Arg Gly Met Phe Asp 
            580                 585                 590         


Asn Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu Cys Phe Ser Phe 
        595                 600                 605             


Ala Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp Glu His Pro Asn 
    610                 615                 620                 


Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln Phe Gln Tyr Ile 
625                 630                 635                 640 


Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr Val Glu Gln Lys 
                645                 650                 655     


Asp Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu Leu Gln Gln Thr 
            660                 665                 670         


Thr Ser Gly Leu Ala His Leu His Ser Leu Asn Ile Val His Arg Asp 
        675                 680                 685             


Leu Lys Pro His Asn Ile Leu Ile Ser Met Pro Asn Ala His Gly Lys 
    690                 695                 700                 


Ile Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Ala Val 
705                 710                 715                 720 


Gly Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro Gly Thr Glu Gly 
                725                 730                 735     


Trp Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys Glu Asn Pro Thr 
            740                 745                 750         


Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Ile 
        755                 760                 765             


Ser Glu Gly Ser His Pro Phe Gly Lys Ser Leu Gln Arg Gln Ala Asn 
    770                 775                 780                 


Ile Leu Leu Gly Ala Cys Ser Leu Asp Cys Leu His Pro Glu Lys His 
785                 790                 795                 800 


Glu Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met Ile Ala Met Asp 
                805                 810                 815     


Pro Gln Lys Arg Pro Ser Ala Lys His Val Leu Lys His Pro Phe Phe 
            820                 825                 830         


Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Arg 
        835                 840                 845             


Ile Glu Lys Glu Ser Leu Asp Gly Pro Ile Val Lys Gln Leu Glu Arg 
    850                 855                 860                 


Gly Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu Asn Ile Thr Val 
865                 870                 875                 880 


Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr Lys Gly Gly Ser 
                885                 890                 895     


Val Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Lys His His Tyr Arg 
            900                 905                 910         


Glu Leu Pro Ala Glu Val Arg Glu Thr Leu Gly Ser Leu Pro Asp Asp 
        915                 920                 925             


Phe Val Cys Tyr Phe Thr Ser Arg Phe Pro His Leu Leu Ala His Thr 
    930                 935                 940                 


Tyr Arg Ala Met Glu Leu Cys Ser His Glu Arg Leu Phe Gln Pro Tyr 
945                 950                 955                 960 


Tyr Phe His Glu Pro Pro Glu Pro Gln Pro Pro Val Thr Pro Asp Ala 
                965                 970                 975     


Leu 
    


<210>  3
<211>  3976
<212>  DNA
<213>  Mus musculus

<400>  3
tccgtgtcca ccgatcctcc gccggtgccg cgctgtcgtt gcggcgcccc cgtccagccc       60

tctgttcgcg cgggctccag aaccggccgg cggggcccgg agtcagggcc acgtcctgcc      120

atgccggccc ggtggctgtt gctcctgctg gcgctgctgc taccgccgcc cggccccggg      180

agttttggaa gaaccagcac agttacactg cctgagacct tgttgtttgt ctcgaccctg      240

gatggaagct tgcatgctgt tagcaagagg acgggctcca tcaagtggac tttaaaagaa      300

gatccagtcc tgcaggtccc aacacacgtg gaagagccgg ctttcctccc agatcccaat      360

gatggcagtc tgtacacact tggaggcaag aacaacgaag gcctgacgaa acttcccttt      420

accatcccag aattggttca ggcctcccca tgccgaagtt cagatggaat cctctacatg      480

ggtaaaaagc aagatatttg gtatgttatc gacctcctga ctggcgagaa gcagcagact      540

ttgtcatcgg cctttgctga tagtctctgc ccatcaactt cccttctata tcttggacgg      600

acagaataca ccatcaccat gtatgacacc aagacccggg agctccgctg gaatgccacc      660

tattttgact atgcagcctc actgccggaa gacgacgtgg actacaagat gtcccacttt      720

gtgtccaatg gcgatggact ggtggtaact gtggacagtg aatctgggga tgtcctgtgg      780

atccaaaact atgcctctcc tgtggtggcc ttctacgtct ggcaggggga ggtcctgaga      840

aaggtggtgc acatcaacgt tgctgtggag actctacgct acttgacctt catgtctggg      900

gaagtggggc gcatcaccaa gtggaagtat ccattcccca aggagacaga ggccaagagc      960

aagctaacgc ctactctgta tgttgggaag tattccacca gcctctatgc ctctccctca     1020

atggtgcatg agggggttgc tgtcgtgcct cgaggcagca ctcttccttt gctggaaggc     1080

ccccagacag atggcgtcac cattggagac aaaggagagt gtgtgatcac tcccagcaca     1140

gacctcaagt ttgaccctgg actcaaaggg aagagcaagc tgaactactt gaggaattac     1200

tggcttctca taggacacca tgaaactcct ctgtctgcat ccaccaagat gctggagaga     1260

tttcctaaca acctgcccaa acatcgagaa aatgtgattc ctgctgattc agaaaaaagg     1320

agctttgagg aagttatcaa catagttggc cagacttcag acaacacacc gaccaccgta     1380

tctcaggatg tggaggagaa gctcgctcgc gcccctgcca agcctgaggc ccccgtggac     1440

tccatgctca aggacatggc taccattatc ctgagcacct tcctgctggt tggatgggtg     1500

gcgttcatca tcacttaccc cctgagcgtg catcagcagc gtcagctcca gcaccaacag     1560

ttccagaagg agctggagaa gattcagctc ctgcagcagc agcagctgcc cttccaccca     1620

cacggagacc ttacccagga ccctgagttc ctggattcat ctggcccctt ctcagagagc     1680

tctggcacca gcagccccag cccatccccc agagcctcca accactccct ccaccccagc     1740

agctctgcct ccagggccgg caccagcccc tctctggagc aggatgatga ggatgaggaa     1800

accagaatgg tgattgttgg gaaaatttca ttctgcccca aggatgtcct gggtcatgga     1860

gctgagggca caattgtata caaaggtatg tttgacaacc gagatgtggc cgtgaagagg     1920

atcctccctg agtgttttag ctttgccgac cgtgaggtcc agctgcttcg agaatcagac     1980

gagcacccaa atgtgatccg ctacttttgc acagagaagg accggcagtt ccagtacatt     2040

gctatcgagc tgtgtgcagc caccctacaa gagtatgtgg agcagaagga ctttgcccac     2100

cttggcctcg agcccatcac cctgcttcat cagaccacct caggcctggc acacctgcat     2160

tctctcaaca ttgttcacag agacctgaag ccccacaaca ttctcctctc catgcccaac     2220

gcacatggca ggatcaaggc gatgatctct gactttggcc tctgcaagaa gctggcagtg     2280

ggcaggcaca gtttcagccg ccgttcaggg gtacctggca ctgaagggtg gatcgcccca     2340

gagatgctga gtgaagactg taaggacaac cctacctaca cggtggacat cttttctgca     2400

ggctgtgtct tttactatgt catctctgag ggcaaccatc cttttggcaa atccttgcag     2460

cggcaggcca acatcctcct gggcgcctgc aaccttgact gtttccactc agacaagcat     2520

gaggacgtca ttgctcgtga attgatagag aaaatgattg ctatggatcc ccagcagcgt     2580

ccctctgcaa agcacgtgct gaaacacccc ttcttctgga gcctggagaa gcagctccag     2640

tttttccagg atgtaagtga ccgaatagaa aaggaggcct tggacggtcc aatcgtacgg     2700

cagttggaga gaggcgggag agctgtggtc aagatggact ggcgggagaa catcactgtc     2760

cccctgcaga cagatctgcg caaattcaga acctacaaag gtggctctgt gagagacctc     2820

ctccgagcca tgagaaacaa gaaacaccac taccgggagc tccccgtgga ggttcaggag     2880

acgctgggct ccatcccgga tgactttgtg cgctacttca cttcccgctt cccccacctc     2940

ctctctcaca cctaccaagc catggagctg tgcagacatg agagactctt tcagacctac     3000

tactggcacg agcccacaga accccagcct ccagtgattc catatgccct ctgagctagg     3060

gcagccctct ggtctggtgg ccccaataat gaccatgggc ccgatctctg cagtcatagt     3120

ttgttgcctc tgggattagc aggaagacta agcttcgcaa atcaagtgcc ttgagctgct     3180

gatctgcagc cagaagagga taacgctgat cctaggacgc aggggaagat ggtccctcat     3240

gactacagag acctgaggag atgtggccct gaaaccttgt agtgaaggac gtctacgaag     3300

gcagcctgtc ccagaggctg caaaggaaac agcatcagcc tttcaccgga tgagcttgct     3360

cccacttctc tttctttcta aaattcctgt gggatggcat tttggggggc ctttcagtga     3420

gagtagagga atctggtttt gcctgcatgg tggaagcagc ctggttgggg tattgcatgt     3480

gcagcctctg atagaaatgg tttgagagat gtggggtgct aaggaagaga tgttcagagg     3540

tgttgccatg gggataggag gcacctccaa gttactgata gcccgtgttg cctcatgcag     3600

caagttgtga gagtgggttg tggagactcg ttagcaatgc tgtggacact gacatgtgct     3660

gtgggtctgg aagatgaagc agacactcag ttctggatgt ggtgctggcc cagcacagtg     3720

gcctaaatag tggcccctga taggttgaat cctggctatg tgggccagag atgagtttcc     3780

tggccaccag gtggcagcta agaccagaca gggacagaga cagattgtca gggccagaga     3840

ggagcaacta gagggagctt cccagtcact caaagatgct aagaactaga aggtgagtga     3900

tatggtccct ctaccccaga ggccagcaga ttagcgcata gattatgaat caaggccctg     3960

ggggtagaga gccaag                                                     3976


<210>  4
<211>  977
<212>  PRT
<213>  Mus musculus

<400>  4

Met Pro Ala Arg Trp Leu Leu Leu Leu Leu Ala Leu Leu Leu Pro Pro 
1               5                   10                  15      


Pro Gly Pro Gly Ser Phe Gly Arg Thr Ser Thr Val Thr Leu Pro Glu 
            20                  25                  30          


Thr Leu Leu Phe Val Ser Thr Leu Asp Gly Ser Leu His Ala Val Ser 
        35                  40                  45              


Lys Arg Thr Gly Ser Ile Lys Trp Thr Leu Lys Glu Asp Pro Val Leu 
    50                  55                  60                  


Gln Val Pro Thr His Val Glu Glu Pro Ala Phe Leu Pro Asp Pro Asn 
65                  70                  75                  80  


Asp Gly Ser Leu Tyr Thr Leu Gly Gly Lys Asn Asn Glu Gly Leu Thr 
                85                  90                  95      


Lys Leu Pro Phe Thr Ile Pro Glu Leu Val Gln Ala Ser Pro Cys Arg 
            100                 105                 110         


Ser Ser Asp Gly Ile Leu Tyr Met Gly Lys Lys Gln Asp Ile Trp Tyr 
        115                 120                 125             


Val Ile Asp Leu Leu Thr Gly Glu Lys Gln Gln Thr Leu Ser Ser Ala 
    130                 135                 140                 


Phe Ala Asp Ser Leu Cys Pro Ser Thr Ser Leu Leu Tyr Leu Gly Arg 
145                 150                 155                 160 


Thr Glu Tyr Thr Ile Thr Met Tyr Asp Thr Lys Thr Arg Glu Leu Arg 
                165                 170                 175     


Trp Asn Ala Thr Tyr Phe Asp Tyr Ala Ala Ser Leu Pro Glu Asp Asp 
            180                 185                 190         


Val Asp Tyr Lys Met Ser His Phe Val Ser Asn Gly Asp Gly Leu Val 
        195                 200                 205             


Val Thr Val Asp Ser Glu Ser Gly Asp Val Leu Trp Ile Gln Asn Tyr 
    210                 215                 220                 


Ala Ser Pro Val Val Ala Phe Tyr Val Trp Gln Gly Glu Val Leu Arg 
225                 230                 235                 240 


Lys Val Val His Ile Asn Val Ala Val Glu Thr Leu Arg Tyr Leu Thr 
                245                 250                 255     


Phe Met Ser Gly Glu Val Gly Arg Ile Thr Lys Trp Lys Tyr Pro Phe 
            260                 265                 270         


Pro Lys Glu Thr Glu Ala Lys Ser Lys Leu Thr Pro Thr Leu Tyr Val 
        275                 280                 285             


Gly Lys Tyr Ser Thr Ser Leu Tyr Ala Ser Pro Ser Met Val His Glu 
    290                 295                 300                 


Gly Val Ala Val Val Pro Arg Gly Ser Thr Leu Pro Leu Leu Glu Gly 
305                 310                 315                 320 


Pro Gln Thr Asp Gly Val Thr Ile Gly Asp Lys Gly Glu Cys Val Ile 
                325                 330                 335     


Thr Pro Ser Thr Asp Leu Lys Phe Asp Pro Gly Leu Lys Gly Lys Ser 
            340                 345                 350         


Lys Leu Asn Tyr Leu Arg Asn Tyr Trp Leu Leu Ile Gly His His Glu 
        355                 360                 365             


Thr Pro Leu Ser Ala Ser Thr Lys Met Leu Glu Arg Phe Pro Asn Asn 
    370                 375                 380                 


Leu Pro Lys His Arg Glu Asn Val Ile Pro Ala Asp Ser Glu Lys Arg 
385                 390                 395                 400 


Ser Phe Glu Glu Val Ile Asn Ile Val Gly Gln Thr Ser Asp Asn Thr 
                405                 410                 415     


Pro Thr Thr Val Ser Gln Asp Val Glu Glu Lys Leu Ala Arg Ala Pro 
            420                 425                 430         


Ala Lys Pro Glu Ala Pro Val Asp Ser Met Leu Lys Asp Met Ala Thr 
        435                 440                 445             


Ile Ile Leu Ser Thr Phe Leu Leu Val Gly Trp Val Ala Phe Ile Ile 
    450                 455                 460                 


Thr Tyr Pro Leu Ser Val His Gln Gln Arg Gln Leu Gln His Gln Gln 
465                 470                 475                 480 


Phe Gln Lys Glu Leu Glu Lys Ile Gln Leu Leu Gln Gln Gln Gln Leu 
                485                 490                 495     


Pro Phe His Pro His Gly Asp Leu Thr Gln Asp Pro Glu Phe Leu Asp 
            500                 505                 510         


Ser Ser Gly Pro Phe Ser Glu Ser Ser Gly Thr Ser Ser Pro Ser Pro 
        515                 520                 525             


Ser Pro Arg Ala Ser Asn His Ser Leu His Pro Ser Ser Ser Ala Ser 
    530                 535                 540                 


Arg Ala Gly Thr Ser Pro Ser Leu Glu Gln Asp Asp Glu Asp Glu Glu 
545                 550                 555                 560 


Thr Arg Met Val Ile Val Gly Lys Ile Ser Phe Cys Pro Lys Asp Val 
                565                 570                 575     


Leu Gly His Gly Ala Glu Gly Thr Ile Val Tyr Lys Gly Met Phe Asp 
            580                 585                 590         


Asn Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu Cys Phe Ser Phe 
        595                 600                 605             


Ala Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp Glu His Pro Asn 
    610                 615                 620                 


Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln Phe Gln Tyr Ile 
625                 630                 635                 640 


Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr Val Glu Gln Lys 
                645                 650                 655     


Asp Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu Leu His Gln Thr 
            660                 665                 670         


Thr Ser Gly Leu Ala His Leu His Ser Leu Asn Ile Val His Arg Asp 
        675                 680                 685             


Leu Lys Pro His Asn Ile Leu Leu Ser Met Pro Asn Ala His Gly Arg 
    690                 695                 700                 


Ile Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Ala Val 
705                 710                 715                 720 


Gly Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro Gly Thr Glu Gly 
                725                 730                 735     


Trp Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys Asp Asn Pro Thr 
            740                 745                 750         


Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Ile 
        755                 760                 765             


Ser Glu Gly Asn His Pro Phe Gly Lys Ser Leu Gln Arg Gln Ala Asn 
    770                 775                 780                 


Ile Leu Leu Gly Ala Cys Asn Leu Asp Cys Phe His Ser Asp Lys His 
785                 790                 795                 800 


Glu Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met Ile Ala Met Asp 
                805                 810                 815     


Pro Gln Gln Arg Pro Ser Ala Lys His Val Leu Lys His Pro Phe Phe 
            820                 825                 830         


Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Arg 
        835                 840                 845             


Ile Glu Lys Glu Ala Leu Asp Gly Pro Ile Val Arg Gln Leu Glu Arg 
    850                 855                 860                 


Gly Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu Asn Ile Thr Val 
865                 870                 875                 880 


Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr Lys Gly Gly Ser 
                885                 890                 895     


Val Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Lys His His Tyr Arg 
            900                 905                 910         


Glu Leu Pro Val Glu Val Gln Glu Thr Leu Gly Ser Ile Pro Asp Asp 
        915                 920                 925             


Phe Val Arg Tyr Phe Thr Ser Arg Phe Pro His Leu Leu Ser His Thr 
    930                 935                 940                 


Tyr Gln Ala Met Glu Leu Cys Arg His Glu Arg Leu Phe Gln Thr Tyr 
945                 950                 955                 960 


Tyr Trp His Glu Pro Thr Glu Pro Gln Pro Pro Val Ile Pro Tyr Ala 
                965                 970                 975     


Leu 
    


<210>  5
<211>  2954
<212>  DNA
<213>  Rattus norvegicus

<400>  5
atgcgcaggt gcaatgacat acaaagtttt ggaagagcca gcacagtaac actgcctgaa       60

gccttgttat ttgtttccac cctggacgga agtttgcatg ctgtcagcaa gaggacaggc      120

tccatcaagt ggactttaaa agaagatcca gtcctgcagg tcccaacaca cgtggaagag      180

cctgctttcc tcccagaccc caatgatggc agtctgtaca cacttggagg caagaacaat      240

gaaggcctga cgaaacttcc ctttaccatc ccggaattgg ttcaggcatc cccatgccga      300

agttcagatg gaattctcta catgggtaag aagcaagaca tttggtatgt catcgacctc      360

ctgactggcg agaagcagca gactttgtca tcagccttcg cagacagtct gtgcccgtca      420

acttcccttc tgtatcttgg acggacagaa tacaccatca ccatgtatga caccaagacc      480

cgggagctcc gctggaatgc cacctatttt gactatgcag cctcacttcc cgaggatgac      540

gtggactaca agatgtccca ctttgtgtcc aatggcgatg gactggtggt aactgtggac      600

agtgaatctg gggatgtctt gtggatccaa aactatgcct ctcctgtggt ggccttctac      660

atctggcagc gggagggcct gagaaaggtg gtgcacatca acgttgctgt ggagacccta      720

cgctatttga ccttcatgtc tggggaagtg gggcgcatca ccaagtggaa atatccattc      780

cccaaggaga cagaggccaa gagcaaactg acgcccactc tgtatgtggg gaagtactcc      840

accagcctct atgcctcgcc ctcgatggtg cacgaggggg tcgctgttgt gcctcgaggc      900

agcactcttc ctttgctcga aggaccccag acagatggtg tcaccattgg agacaaagga      960

gaatgtgtga tcactcccag cacagacctc aagtttgacc ctggactcaa aggcaagagc     1020

aagctgaact acctgaggaa ttactggctt ctcataggac accatgaaac tcctctgtct     1080

gcatccacca agatgctgga gagatttcct aacaatcttc ccaaacatcg agaaaacgtg     1140

attcctgctg attcggagaa aaggagcttt gaggaggtta tcaacctagt tggccagact     1200

tcagaaaaca caccaaccac tgtgtctcag gatgtagaag agaagctgcc ccgtgccccc     1260

gccaagccag aggcccccgt ggactccatg ctcaaggaca tggctactat tatcctgagc     1320

accttcctgc tggtcggatg ggtggcgttc atcatcactt accccctgag catgcatcag     1380

cagcgccagc tccagcacca gcagttccag aaggaactgg agaaaattca gctccttcag     1440

caacagcagc tgcccttcca cccacacgga gaccttaccc aggaccctga cttcctggat     1500

tcatctggcc tcttctcgga gagctcaggc accagcagcc ccagcccatc ccccagagcc     1560

tccaaccact cactcaactc tagcagctct gcctccaagg ctggcaccag tccctccctg     1620

gagccagatg acgaggatga ggaaaccaga atggtgattg ttgggaaaat ctcattctgc     1680

cccaaggatg tcctgggcca tggagctgag ggcacaattg tatacaaagg tatgtttgac     1740

aaccgtgatg tggccgtgaa gaggatcctc cctgagtgtt ttagctttgc agaccgagag     1800

gtccagctgc ttcgagaatc agacgagcat ccgaatgtga tccgctactt ttgcacagag     1860

aaggaccggc agttccagta cattgccatt gagctgtgtg cagctaccct gcaggagtat     1920

gtggagcaga aggacttcgc ccaccttggc ctagagccca tcaccttgct tcatcagacc     1980

acctcaggcc tggcgcacct gcattccctc aacattgttc acagagacct gaagccccac     2040

aacattctcc tctccatgcc caacgcacat ggcaggatca aggcgatgat ctcagacttt     2100

ggcctctgca agaagctggc agtgggcagg catagtttca gccgccgttc aggggtgcct     2160

ggcactgaag gttggatcgc cccagagatg ctgagtgaag actgcaagga gaaccctacc     2220

tacacagtgg acatcttctc tgcaggctgt gtcttttact atgtcatctc tgagggcaac     2280

catccttttg gcaaatcctt gcagcggcag gccaacatcc tcctgggcgc ctgcagcctt     2340

gactgcttcc actcagacaa gcacgaggac gtcattgctc gtgagttgat agagaaaatg     2400

attgcaatgg atccgcagca gcgaccctcg gcaaagcacg tgctaaaaca cccattcttc     2460

tggagcctgg aaaagcagct ccagttcttc caggatgtga gtgaccgaat agaaaaggag     2520

tccttggatg gcccgatcgt gcggcagttg gagagaggcg ggagagctgt ggttaagatg     2580

gactggcggg agaacatcac tgtccccctg cagacagatc tgcgcaaatt cagaacctat     2640

aaaggtggct ccgtccggga tctcctccga gccatgagga ataagagaca ccactaccgg     2700

gagctccctc tggaggttca ggagacgctg ggctccatcc ctgatgactt cgtgcgctac     2760

ttcacatcac gtttccccca cctcctctct cacacctacc gagccatgga actgtgcaga     2820

catgagagac ttttccagac ctactactgg cacgagccca cagaagccca gcctccaggg     2880

attccagatg ccctctgagc gagggcagcc ctctggtctg gtggccccaa caaggaccat     2940

gggcctgatc tctg                                                       2954


<210>  6
<211>  965
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Arg Arg Cys Asn Asp Ile Gln Ser Phe Gly Arg Ala Ser Thr Val 
1               5                   10                  15      


Thr Leu Pro Glu Ala Leu Leu Phe Val Ser Thr Leu Asp Gly Ser Leu 
            20                  25                  30          


His Ala Val Ser Lys Arg Thr Gly Ser Ile Lys Trp Thr Leu Lys Glu 
        35                  40                  45              


Asp Pro Val Leu Gln Val Pro Thr His Val Glu Glu Pro Ala Phe Leu 
    50                  55                  60                  


Pro Asp Pro Asn Asp Gly Ser Leu Tyr Thr Leu Gly Gly Lys Asn Asn 
65                  70                  75                  80  


Glu Gly Leu Thr Lys Leu Pro Phe Thr Ile Pro Glu Leu Val Gln Ala 
                85                  90                  95      


Ser Pro Cys Arg Ser Ser Asp Gly Ile Leu Tyr Met Gly Lys Lys Gln 
            100                 105                 110         


Asp Ile Trp Tyr Val Ile Asp Leu Leu Thr Gly Glu Lys Gln Gln Thr 
        115                 120                 125             


Leu Ser Ser Ala Phe Ala Asp Ser Leu Cys Pro Ser Thr Ser Leu Leu 
    130                 135                 140                 


Tyr Leu Gly Arg Thr Glu Tyr Thr Ile Thr Met Tyr Asp Thr Lys Thr 
145                 150                 155                 160 


Arg Glu Leu Arg Trp Asn Ala Thr Tyr Phe Asp Tyr Ala Ala Ser Leu 
                165                 170                 175     


Pro Glu Asp Asp Val Asp Tyr Lys Met Ser His Phe Val Ser Asn Gly 
            180                 185                 190         


Asp Gly Leu Val Val Thr Val Asp Ser Glu Ser Gly Asp Val Leu Trp 
        195                 200                 205             


Ile Gln Asn Tyr Ala Ser Pro Val Val Ala Phe Tyr Ile Trp Gln Arg 
    210                 215                 220                 


Glu Gly Leu Arg Lys Val Val His Ile Asn Val Ala Val Glu Thr Leu 
225                 230                 235                 240 


Arg Tyr Leu Thr Phe Met Ser Gly Glu Val Gly Arg Ile Thr Lys Trp 
                245                 250                 255     


Lys Tyr Pro Phe Pro Lys Glu Thr Glu Ala Lys Ser Lys Leu Thr Pro 
            260                 265                 270         


Thr Leu Tyr Val Gly Lys Tyr Ser Thr Ser Leu Tyr Ala Ser Pro Ser 
        275                 280                 285             


Met Val His Glu Gly Val Ala Val Val Pro Arg Gly Ser Thr Leu Pro 
    290                 295                 300                 


Leu Leu Glu Gly Pro Gln Thr Asp Gly Val Thr Ile Gly Asp Lys Gly 
305                 310                 315                 320 


Glu Cys Val Ile Thr Pro Ser Thr Asp Leu Lys Phe Asp Pro Gly Leu 
                325                 330                 335     


Lys Gly Lys Ser Lys Leu Asn Tyr Leu Arg Asn Tyr Trp Leu Leu Ile 
            340                 345                 350         


Gly His His Glu Thr Pro Leu Ser Ala Ser Thr Lys Met Leu Glu Arg 
        355                 360                 365             


Phe Pro Asn Asn Leu Pro Lys His Arg Glu Asn Val Ile Pro Ala Asp 
    370                 375                 380                 


Ser Glu Lys Arg Ser Phe Glu Glu Val Ile Asn Leu Val Gly Gln Thr 
385                 390                 395                 400 


Ser Glu Asn Thr Pro Thr Thr Val Ser Gln Asp Val Glu Glu Lys Leu 
                405                 410                 415     


Pro Arg Ala Pro Ala Lys Pro Glu Ala Pro Val Asp Ser Met Leu Lys 
            420                 425                 430         


Asp Met Ala Thr Ile Ile Leu Ser Thr Phe Leu Leu Val Gly Trp Val 
        435                 440                 445             


Ala Phe Ile Ile Thr Tyr Pro Leu Ser Met His Gln Gln Arg Gln Leu 
    450                 455                 460                 


Gln His Gln Gln Phe Gln Lys Glu Leu Glu Lys Ile Gln Leu Leu Gln 
465                 470                 475                 480 


Gln Gln Gln Leu Pro Phe His Pro His Gly Asp Leu Thr Gln Asp Pro 
                485                 490                 495     


Asp Phe Leu Asp Ser Ser Gly Leu Phe Ser Glu Ser Ser Gly Thr Ser 
            500                 505                 510         


Ser Pro Ser Pro Ser Pro Arg Ala Ser Asn His Ser Leu Asn Ser Ser 
        515                 520                 525             


Ser Ser Ala Ser Lys Ala Gly Thr Ser Pro Ser Leu Glu Pro Asp Asp 
    530                 535                 540                 


Glu Asp Glu Glu Thr Arg Met Val Ile Val Gly Lys Ile Ser Phe Cys 
545                 550                 555                 560 


Pro Lys Asp Val Leu Gly His Gly Ala Glu Gly Thr Ile Val Tyr Lys 
                565                 570                 575     


Gly Met Phe Asp Asn Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu 
            580                 585                 590         


Cys Phe Ser Phe Ala Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp 
        595                 600                 605             


Glu His Pro Asn Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln 
    610                 615                 620                 


Phe Gln Tyr Ile Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr 
625                 630                 635                 640 


Val Glu Gln Lys Asp Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu 
                645                 650                 655     


Leu His Gln Thr Thr Ser Gly Leu Ala His Leu His Ser Leu Asn Ile 
            660                 665                 670         


Val His Arg Asp Leu Lys Pro His Asn Ile Leu Leu Ser Met Pro Asn 
        675                 680                 685             


Ala His Gly Arg Ile Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys 
    690                 695                 700                 


Lys Leu Ala Val Gly Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro 
705                 710                 715                 720 


Gly Thr Glu Gly Trp Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys 
                725                 730                 735     


Glu Asn Pro Thr Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe 
            740                 745                 750         


Tyr Tyr Val Ile Ser Glu Gly Asn His Pro Phe Gly Lys Ser Leu Gln 
        755                 760                 765             


Arg Gln Ala Asn Ile Leu Leu Gly Ala Cys Ser Leu Asp Cys Phe His 
    770                 775                 780                 


Ser Asp Lys His Glu Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met 
785                 790                 795                 800 


Ile Ala Met Asp Pro Gln Gln Arg Pro Ser Ala Lys His Val Leu Lys 
                805                 810                 815     


His Pro Phe Phe Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp 
            820                 825                 830         


Val Ser Asp Arg Ile Glu Lys Glu Ser Leu Asp Gly Pro Ile Val Arg 
        835                 840                 845             


Gln Leu Glu Arg Gly Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu 
    850                 855                 860                 


Asn Ile Thr Val Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr 
865                 870                 875                 880 


Lys Gly Gly Ser Val Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Arg 
                885                 890                 895     


His His Tyr Arg Glu Leu Pro Leu Glu Val Gln Glu Thr Leu Gly Ser 
            900                 905                 910         


Ile Pro Asp Asp Phe Val Arg Tyr Phe Thr Ser Arg Phe Pro His Leu 
        915                 920                 925             


Leu Ser His Thr Tyr Arg Ala Met Glu Leu Cys Arg His Glu Arg Leu 
    930                 935                 940                 


Phe Gln Thr Tyr Tyr Trp His Glu Pro Thr Glu Ala Gln Pro Pro Gly 
945                 950                 955                 960 


Ile Pro Asp Ala Leu 
                965 


<210>  7
<211>  1810
<212>  DNA
<213>  Homo sapiens

<400>  7
ggcgctgggc ggctgcggcg cgcggtgcgc ggtgcgtagt ctggagctat ggtggtggtg       60

gcagccgcgc cgaacccggc cgacgggacc cctaaagttc tgcttctgtc ggggcagccc      120

gcctccgccg ccggagcccc ggccggccag gccctgccgc tcatggtgcc agcccagaga      180

ggggccagcc cggaggcagc gagcgggggg ctgccccagg cgcgcaagcg acagcgcctc      240

acgcacctga gccccgagga gaaggcgctg aggaggaaac tgaaaaacag agtagcagct      300

cagactgcca gagatcgaaa gaaggctcga atgagtgagc tggaacagca agtggtagat      360

ttagaagaag agaaccaaaa acttttgcta gaaaatcagc ttttacgaga gaaaactcat      420

ggccttgtag ttgagaacca ggagttaaga cagcgcttgg ggatggatgc cctggttgct      480

gaagaggagg cggaagccaa ggggaatgaa gtgaggccag tggccgggtc tgctgagtcc      540

gcagcaggtg caggcccagt tgtcacccct ccagaacatc tccccatgga ttctggcggt      600

attgactctt cagattcaga gtctgatatc ctgttgggca ttctggacaa cttggaccca      660

gtcatgttct tcaaatgccc ttccccagag cctgccagcc tggaggagct cccagaggtc      720

tacccagaag gacccagttc cttaccagcc tccctttctc tgtcagtggg gacgtcatca      780

gccaagctgg aagccattaa tgaactaatt cgttttgacc acatatatac caagccccta      840

gtcttagaga taccctctga gacagagagc caagctaatg tggtagtgaa aatcgaggaa      900

gcacctctca gcccctcaga gaatgatcac cctgaattca ttgtctcagt gaaggaagaa      960

cctgtagaag atgacctcgt tccggagctg ggtatctcaa atctgctttc atccagccac     1020

tgcccaaagc catcttcctg cctactggat gcttacagtg actgtggata cgggggttcc     1080

ctttccccat tcagtgacat gtcctctctg cttggtgtaa accattcttg ggaggacact     1140

tttgccaatg aactctttcc ccagctgatt agtgtctaag gaatgatcca atactgttgc     1200

ccttttcctt gactattaca ctgcctggag gatagcagag aagcctgtct gtacttcatt     1260

caaaaagcca aaatagagag tatacagtcc tagagaattc ctctatttgt tcagatctca     1320

tagatgaccc ccaggtattg tcttttgaca tccagcagtc caaggtattg agacatatta     1380

ctggaagtaa gaaatattac tataattgag aactacagct tttaagattg tacttttatc     1440

ttaaaagggt ggtagttttc cctaaaatac ttattatgta agggtcatta gacaaatgtc     1500

ttgaagtaga catggaattt atgaatggtt ctttatcatt tctcttcccc ctttttggca     1560

tcctggcttg cctccagttt taggtccttt agtttgcttc tgtaagcaac gggaacacct     1620

gctgaggggg ctctttccct catgtatact tcaagtaaga tcaagaatct tttgtgaaat     1680

tatagaaatt tactatgtaa atgcttgatg gaattttttc ctgctagtgt agcttctgaa     1740

aggtgctttc tccatttatt taaaactacc catgcaatta aaaggtacaa tgcaaaaaaa     1800

aaaaaaaaaa                                                            1810


<210>  8
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Val Val Ala Ala Ala Pro Asn Pro Ala Asp Gly Thr Pro Lys 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Ala Ala Gly Ala Pro Ala 
            20                  25                  30          


Gly Gln Ala Leu Pro Leu Met Val Pro Ala Gln Arg Gly Ala Ser Pro 
        35                  40                  45              


Glu Ala Ala Ser Gly Gly Leu Pro Gln Ala Arg Lys Arg Gln Arg Leu 
    50                  55                  60                  


Thr His Leu Ser Pro Glu Glu Lys Ala Leu Arg Arg Lys Leu Lys Asn 
65                  70                  75                  80  


Arg Val Ala Ala Gln Thr Ala Arg Asp Arg Lys Lys Ala Arg Met Ser 
                85                  90                  95      


Glu Leu Glu Gln Gln Val Val Asp Leu Glu Glu Glu Asn Gln Lys Leu 
            100                 105                 110         


Leu Leu Glu Asn Gln Leu Leu Arg Glu Lys Thr His Gly Leu Val Val 
        115                 120                 125             


Glu Asn Gln Glu Leu Arg Gln Arg Leu Gly Met Asp Ala Leu Val Ala 
    130                 135                 140                 


Glu Glu Glu Ala Glu Ala Lys Gly Asn Glu Val Arg Pro Val Ala Gly 
145                 150                 155                 160 


Ser Ala Glu Ser Ala Ala Gly Ala Gly Pro Val Val Thr Pro Pro Glu 
                165                 170                 175     


His Leu Pro Met Asp Ser Gly Gly Ile Asp Ser Ser Asp Ser Glu Ser 
            180                 185                 190         


Asp Ile Leu Leu Gly Ile Leu Asp Asn Leu Asp Pro Val Met Phe Phe 
        195                 200                 205             


Lys Cys Pro Ser Pro Glu Pro Ala Ser Leu Glu Glu Leu Pro Glu Val 
    210                 215                 220                 


Tyr Pro Glu Gly Pro Ser Ser Leu Pro Ala Ser Leu Ser Leu Ser Val 
225                 230                 235                 240 


Gly Thr Ser Ser Ala Lys Leu Glu Ala Ile Asn Glu Leu Ile Arg Phe 
                245                 250                 255     


Asp His Ile Tyr Thr Lys Pro Leu Val Leu Glu Ile Pro Ser Glu Thr 
            260                 265                 270         


Glu Ser Gln Ala Asn Val Val Val Lys Ile Glu Glu Ala Pro Leu Ser 
        275                 280                 285             


Pro Ser Glu Asn Asp His Pro Glu Phe Ile Val Ser Val Lys Glu Glu 
    290                 295                 300                 


Pro Val Glu Asp Asp Leu Val Pro Glu Leu Gly Ile Ser Asn Leu Leu 
305                 310                 315                 320 


Ser Ser Ser His Cys Pro Lys Pro Ser Ser Cys Leu Leu Asp Ala Tyr 
                325                 330                 335     


Ser Asp Cys Gly Tyr Gly Gly Ser Leu Ser Pro Phe Ser Asp Met Ser 
            340                 345                 350         


Ser Leu Leu Gly Val Asn His Ser Trp Glu Asp Thr Phe Ala Asn Glu 
        355                 360                 365             


Leu Phe Pro Gln Leu Ile Ser Val 
    370                 375     


<210>  9
<211>  1820
<212>  DNA
<213>  Homo sapiens

<400>  9
ggcgctgggc ggctgcggcg cgcggtgcgc ggtgcgtagt ctggagctat ggtggtggtg       60

gcagccgcgc cgaacccggc cgacgggacc cctaaagttc tgcttctgtc ggggcagccc      120

gcctccgccg ccggagcccc ggccggccag gccctgccgc tcatggtgcc agcccagaga      180

ggggccagcc cggaggcagc gagcgggggg ctgccccagg cgcgcaagcg acagcgcctc      240

acgcacctga gccccgagga gaaggcgctg aggaggaaac tgaaaaacag agtagcagct      300

cagactgcca gagatcgaaa gaaggctcga atgagtgagc tggaacagca agtggtagat      360

ttagaagaag agaaccaaaa acttttgcta gaaaatcagc ttttacgaga gaaaactcat      420

ggccttgtag ttgagaacca ggagttaaga cagcgcttgg ggatggatgc cctggttgct      480

gaagaggagg cggaagccaa ggggaatgaa gtgaggccag tggccgggtc tgctgagtcc      540

gcagcactca gactacgtgc acctctgcag caggtgcagg cccagttgtc acccctccag      600

aacatctccc catggattct ggcggtattg actcttcaga ttcagagtct gatatcctgt      660

tgggcattct ggacaacttg gacccagtca tgttcttcaa atgcccttcc ccagagcctg      720

ccagcctgga ggagctccca gaggtctacc cagaaggacc cagttcctta ccagcctccc      780

tttctctgtc agtggggacg tcatcagcca agctggaagc cattaatgaa ctaattcgtt      840

ttgaccacat atataccaag cccctagtct tagagatacc ctctgagaca gagagccaag      900

ctaatgtggt agtgaaaatc gaggaagcac ctctcagccc ctcagagaat gatcaccctg      960

aattcattgt ctcagtgaag gaagaacctg tagaagatga cctcgttccg gagctgggta     1020

tctcaaatct gctttcatcc agccactgcc caaagccatc ttcctgccta ctggatgctt     1080

acagtgactg tggatacggg ggttcccttt ccccattcag tgacatgtcc tctctgcttg     1140

gtgtaaacca ttcttgggag gacacttttg ccaatgaact ctttccccag ctgattagtg     1200

tctaaggaat gatccaatac tgttgccctt ttccttgact attacactgc ctggaggata     1260

gcagagaagc ctgtctgtac ttcattcaaa aagccaaaat agagagtata cagtcctaga     1320

gaattcctct atttgttcag atctcataga tgacccccag gtattgtctt ttgacatcca     1380

gcagtccaag gtattgagac atattactgg aagtaagaaa tattactata attgagaact     1440

acagctttta agattgtact tttatcttaa aagggtggta gttttcccta aaatacttat     1500

tatgtaaggg tcattagaca aatgtcttga agtagacatg gaatttatga atggttcttt     1560

atcatttctc ttcccccttt ttggcatcct ggcttgcctc cagttttagg tcctttagtt     1620

tgcttctgta agcaacggga acacctgctg agggggctct ttccctcatg tatacttcaa     1680

gtaagatcaa gaatcttttg tgaaattata gaaatttact atgtaaatgc ttgatggaat     1740

tttttcctgc tagtgtagct tctgaaaggt gctttctcca tttatttaaa actacccatg     1800

caattaaaag gtacaatgca                                                 1820


<210>  10
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Val Val Val Ala Ala Ala Pro Asn Pro Ala Asp Gly Thr Pro Lys 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Ala Ala Gly Ala Pro Ala 
            20                  25                  30          


Gly Gln Ala Leu Pro Leu Met Val Pro Ala Gln Arg Gly Ala Ser Pro 
        35                  40                  45              


Glu Ala Ala Ser Gly Gly Leu Pro Gln Ala Arg Lys Arg Gln Arg Leu 
    50                  55                  60                  


Thr His Leu Ser Pro Glu Glu Lys Ala Leu Arg Arg Lys Leu Lys Asn 
65                  70                  75                  80  


Arg Val Ala Ala Gln Thr Ala Arg Asp Arg Lys Lys Ala Arg Met Ser 
                85                  90                  95      


Glu Leu Glu Gln Gln Val Val Asp Leu Glu Glu Glu Asn Gln Lys Leu 
            100                 105                 110         


Leu Leu Glu Asn Gln Leu Leu Arg Glu Lys Thr His Gly Leu Val Val 
        115                 120                 125             


Glu Asn Gln Glu Leu Arg Gln Arg Leu Gly Met Asp Ala Leu Val Ala 
    130                 135                 140                 


Glu Glu Glu Ala Glu Ala Lys Gly Asn Glu Val Arg Pro Val Ala Gly 
145                 150                 155                 160 


Ser Ala Glu Ser Ala Ala Leu Arg Leu Arg Ala Pro Leu Gln Gln Val 
                165                 170                 175     


Gln Ala Gln Leu Ser Pro Leu Gln Asn Ile Ser Pro Trp Ile Leu Ala 
            180                 185                 190         


Val Leu Thr Leu Gln Ile Gln Ser Leu Ile Ser Cys Trp Ala Phe Trp 
        195                 200                 205             


Thr Thr Trp Thr Gln Ser Cys Ser Ser Asn Ala Leu Pro Gln Ser Leu 
    210                 215                 220                 


Pro Ala Trp Arg Ser Ser Gln Arg Ser Thr Gln Lys Asp Pro Val Pro 
225                 230                 235                 240 


Tyr Gln Pro Pro Phe Leu Cys Gln Trp Gly Arg His Gln Pro Ser Trp 
                245                 250                 255     


Lys Pro Leu Met Asn 
            260     


<210>  11
<211>  2264
<212>  DNA
<213>  Mus musculus

<400>  11
ctagggtaaa accgtgagac tcggtctgga aatctggcct gagaggacag cctggcaatc       60

ctcagccggg gtggggacgt ctgccgaaga tccttggact ccagcaacca gtggtcgcca      120

ccgtccatcc accctaaggc ccagtttgca cggcggagaa cagctgtgca gccacgctgg      180

acactcaccc cgcccgagtt gagcccgccc ccgggactac aggaccaata agtgatgaat      240

atacccgcgc gtcacggagc accggccaat cgcggacggc cacgacccta gaaaggctgg      300

gcgcggcagg aggccacggg gcggtggcgg cgctggcgta gacgtttcct ggctatggtg      360

gtggtggcag cggcgccgag cgcggccacg gcggccccca aagtgctact cttatctggc      420

cagcccgcct ccggcggccg ggcgctgccg ctcatggtac ccggtccgcg ggcagcaggg      480

tcggaggcga gcgggacacc gcaggctcgc aagcggcagc ggctcacgca cctgagcccg      540

gaggagaaag cgctgcggag gaaactgaaa aacagagtag cagcgcagac tgctcgagat      600

agaaagaaag cccggatgag cgagctggag cagcaagtgg tggatttgga agaagagaac      660

cacaaactcc agctagaaaa tcagctttta cgggagaaaa ctcacggcct tgtggttgag      720

aaccaggagt taagaacacg cttgggaatg gacacgctgg atcctgacga ggttccagag      780

gtggaggcca aggggagtgg agtaaggctg gtggccgggt ctgctgagtc cgcagcactc      840

agactatgtg cacctctgca gcaggtgcag gcccagttgt cacctcccca gaacatcttc      900

ccatggactc tgacactgtt gcctcttcag attctgagtc tgatatcctt ttgggcattc      960

tggacaagtt ggaccctgtc atgtttttca aatgtccttc cccagagtct gctagtctgg     1020

aggaactccc agaggtctac ccagaaggac ctagttcctt accagcctcc ctttctctgt     1080

cagtggggac ctcatcagcc aagctggaag ccattaatga actcattcgt tttgaccatg     1140

tatacaccaa gcctctagtt ttagagatcc cctctgagac agagagtcaa actaacgtgg     1200

tagtgaaaat tgaggaagca cctctaagct cttcagaaga ggatcaccct gaattcattg     1260

tctcagtgaa gaaagagcct ttggaagatg acttcatccc agagctgggc atctcaaacc     1320

tgctttcatc cagccattgt ctgagaccac cttcttgcct gctggacgct cacagtgact     1380

gtggatatga gggctcccct tctcccttca gtgacatgtc ttctccactt ggtacagacc     1440

actcctggga ggatactttt gccaatgaac ttttccccca gctgattagt gtctaaagag     1500

ccacataaca ctgggcccct ttccctgacc atcacattgc ctagaggata gcataggcct     1560

gtctctttcg ttaaaagcca aagtagaggc tgtctggcct tagaagaatt cctctaaagt     1620

atttcaaatc tcatagatga cttccaagta ttgtcgtttg acactcagct gtctaaggta     1680

ttcaaaggta ttccagtact acagcttttg agattctagt ttatcttaaa ggtggtagta     1740

tactctaaat cgcagggagg gtcatttgac agttttttcc cagcctggct tcaaactatg     1800

tagccgaggc taggcagaaa cttctgaccc tcttgacccc acctcccaag tgctgggctt     1860

caccaggtgt gcacctccac acctgccccc ccgacatgtc aggtggacat gggattcatg     1920

aatggccctt agcatttctt tctccactct ctgcttccca ggtttcgtaa cctgaggggg     1980

cttgttttcc cttatgtgca ttttaaatga agatcaagaa tctttgtaaa atgatgaaaa     2040

tttactatgt aaatgcttga tggatcttct tgctagtgta gcttctagaa ggtgctttct     2100

ccatttattt aaaactaccc ttgcaattaa aaaaaaagca acacagcgtc ctgttctgtg     2160

atttctaggg ctgttgtaat ttctctttat tgttggctaa aggagtaatt tatccaacta     2220

aagtgagcat accacttttt aaagtcaaaa aaaaaaaaaa aaaa                      2264


<210>  12
<211>  267
<212>  PRT
<213>  Mus musculus

<400>  12

Met Val Val Val Ala Ala Ala Pro Ser Ala Ala Thr Ala Ala Pro Lys 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Gly Gly Arg Ala Leu Pro 
            20                  25                  30          


Leu Met Val Pro Gly Pro Arg Ala Ala Gly Ser Glu Ala Ser Gly Thr 
        35                  40                  45              


Pro Gln Ala Arg Lys Arg Gln Arg Leu Thr His Leu Ser Pro Glu Glu 
    50                  55                  60                  


Lys Ala Leu Arg Arg Lys Leu Lys Asn Arg Val Ala Ala Gln Thr Ala 
65                  70                  75                  80  


Arg Asp Arg Lys Lys Ala Arg Met Ser Glu Leu Glu Gln Gln Val Val 
                85                  90                  95      


Asp Leu Glu Glu Glu Asn His Lys Leu Gln Leu Glu Asn Gln Leu Leu 
            100                 105                 110         


Arg Glu Lys Thr His Gly Leu Val Val Glu Asn Gln Glu Leu Arg Thr 
        115                 120                 125             


Arg Leu Gly Met Asp Thr Leu Asp Pro Asp Glu Val Pro Glu Val Glu 
    130                 135                 140                 


Ala Lys Gly Ser Gly Val Arg Leu Val Ala Gly Ser Ala Glu Ser Ala 
145                 150                 155                 160 


Ala Leu Arg Leu Cys Ala Pro Leu Gln Gln Val Gln Ala Gln Leu Ser 
                165                 170                 175     


Pro Pro Gln Asn Ile Phe Pro Trp Thr Leu Thr Leu Leu Pro Leu Gln 
            180                 185                 190         


Ile Leu Ser Leu Ile Ser Phe Trp Ala Phe Trp Thr Ser Trp Thr Leu 
        195                 200                 205             


Ser Cys Phe Ser Asn Val Leu Pro Gln Ser Leu Leu Val Trp Arg Asn 
    210                 215                 220                 


Ser Gln Arg Ser Thr Gln Lys Asp Leu Val Pro Tyr Gln Pro Pro Phe 
225                 230                 235                 240 


Leu Cys Gln Trp Gly Pro His Gln Pro Ser Trp Lys Pro Leu Met Asn 
                245                 250                 255     


Ser Phe Val Leu Thr Met Tyr Thr Pro Ser Leu 
            260                 265         


<210>  13
<211>  2238
<212>  DNA
<213>  Mus musculus

<400>  13
ctagggtaaa accgtgagac tcggtctgga aatctggcct gagaggacag cctggcaatc       60

ctcagccggg gtggggacgt ctgccgaaga tccttggact ccagcaacca gtggtcgcca      120

ccgtccatcc accctaaggc ccagtttgca cggcggagaa cagctgtgca gccacgctgg      180

acactcaccc cgcccgagtt gagcccgccc ccgggactac aggaccaata agtgatgaat      240

atacccgcgc gtcacggagc accggccaat cgcggacggc cacgacccta gaaaggctgg      300

gcgcggcagg aggccacggg gcggtggcgg cgctggcgta gacgtttcct ggctatggtg      360

gtggtggcag cggcgccgag cgcggccacg gcggccccca aagtgctact cttatctggc      420

cagcccgcct ccggcggccg ggcgctgccg ctcatggtac ccggtccgcg ggcagcaggg      480

tcggaggcga gcgggacacc gcaggctcgc aagcggcagc ggctcacgca cctgagcccg      540

gaggagaaag cgctgcggag gaaactgaaa aacagagtag cagcgcagac tgctcgagat      600

agaaagaaag cccggatgag cgagctggag cagcaagtgg tggatttgga agaagagaac      660

cacaaactcc agctagaaaa tcagctttta cgggagaaaa ctcacggcct tgtggttgag      720

aaccaggagt taagaacacg cttgggaatg gacacgctgg atcctgacga ggttccagag      780

gtggaggcca aggggagtgg agtaaggctg gtggccgggt ctgctgagtc cgcagcaggt      840

gcaggcccag ttgtcacctc cccagaacat cttcccatgg actctgacac tgttgcctct      900

tcagattctg agtctgatat ccttttgggc attctggaca agttggaccc tgtcatgttt      960

ttcaaatgtc cttccccaga gtctgctagt ctggaggaac tcccagaggt ctacccagaa     1020

ggacctagtt ccttaccagc ctccctttct ctgtcagtgg ggacctcatc agccaagctg     1080

gaagccatta atgaactcat tcgttttgac catgtataca ccaagcctct agttttagag     1140

atcccctctg agacagagag tcaaactaac gtggtagtga aaattgagga agcacctcta     1200

agctcttcag aagaggatca ccctgaattc attgtctcag tgaagaaaga gcctttggaa     1260

gatgacttca tcccagagct gggcatctca aacctgcttt catccagcca ttgtctgaga     1320

ccaccttctt gcctgctgga cgctcacagt gactgtggat atgagggctc cccttctccc     1380

ttcagtgaca tgtcttctcc acttggtaca gaccactcct gggaggatac ttttgccaat     1440

gaacttttcc cccagctgat tagtgtctaa agagccacat aacactgggc ccctttccct     1500

gaccatcaca ttgcctagag gatagcatag gcctgtctct ttcgttaaaa gccaaagtag     1560

aggctgtctg gccttagaag aattcctcta aagtatttca aatctcatag atgacttcca     1620

agtattgtcg tttgacactc agctgtctaa ggtattcaaa ggtattccag tactacagct     1680

tttgagattc tagtttatct taaaggtggt agtatactct aaatcgcagg gagggtcatt     1740

tgacagtttt ttcccagcct ggcttcaaac tatgtagccg aggctaggca gaaacttctg     1800

accctcttga ccccacctcc caagtgctgg gcttcaccag gtgtgcacct ccacacctgc     1860

ccccccgaca tgtcaggtgg acatgggatt catgaatggc ccttagcatt tctttctcca     1920

ctctctgctt cccaggtttc gtaacctgag ggggcttgtt ttcccttatg tgcattttaa     1980

atgaagatca agaatctttg taaaatgatg aaaatttact atgtaaatgc ttgatggatc     2040

ttcttgctag tgtagcttct agaaggtgct ttctccattt atttaaaact acccttgcaa     2100

ttaaaaaaaa agcaacacag cgtcctgttc tgtgatttct agggctgttg taatttctct     2160

ttattgttgg ctaaaggagt aatttatcca actaaagtga gcataccact ttttaaagtc     2220

aaaaaaaaaa aaaaaaaa                                                   2238


<210>  14
<211>  371
<212>  PRT
<213>  Mus musculus

<400>  14

Met Val Val Val Ala Ala Ala Pro Ser Ala Ala Thr Ala Ala Pro Lys 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Gly Gly Arg Ala Leu Pro 
            20                  25                  30          


Leu Met Val Pro Gly Pro Arg Ala Ala Gly Ser Glu Ala Ser Gly Thr 
        35                  40                  45              


Pro Gln Ala Arg Lys Arg Gln Arg Leu Thr His Leu Ser Pro Glu Glu 
    50                  55                  60                  


Lys Ala Leu Arg Arg Lys Leu Lys Asn Arg Val Ala Ala Gln Thr Ala 
65                  70                  75                  80  


Arg Asp Arg Lys Lys Ala Arg Met Ser Glu Leu Glu Gln Gln Val Val 
                85                  90                  95      


Asp Leu Glu Glu Glu Asn His Lys Leu Gln Leu Glu Asn Gln Leu Leu 
            100                 105                 110         


Arg Glu Lys Thr His Gly Leu Val Val Glu Asn Gln Glu Leu Arg Thr 
        115                 120                 125             


Arg Leu Gly Met Asp Thr Leu Asp Pro Asp Glu Val Pro Glu Val Glu 
    130                 135                 140                 


Ala Lys Gly Ser Gly Val Arg Leu Val Ala Gly Ser Ala Glu Ser Ala 
145                 150                 155                 160 


Ala Gly Ala Gly Pro Val Val Thr Ser Pro Glu His Leu Pro Met Asp 
                165                 170                 175     


Ser Asp Thr Val Ala Ser Ser Asp Ser Glu Ser Asp Ile Leu Leu Gly 
            180                 185                 190         


Ile Leu Asp Lys Leu Asp Pro Val Met Phe Phe Lys Cys Pro Ser Pro 
        195                 200                 205             


Glu Ser Ala Ser Leu Glu Glu Leu Pro Glu Val Tyr Pro Glu Gly Pro 
    210                 215                 220                 


Ser Ser Leu Pro Ala Ser Leu Ser Leu Ser Val Gly Thr Ser Ser Ala 
225                 230                 235                 240 


Lys Leu Glu Ala Ile Asn Glu Leu Ile Arg Phe Asp His Val Tyr Thr 
                245                 250                 255     


Lys Pro Leu Val Leu Glu Ile Pro Ser Glu Thr Glu Ser Gln Thr Asn 
            260                 265                 270         


Val Val Val Lys Ile Glu Glu Ala Pro Leu Ser Ser Ser Glu Glu Asp 
        275                 280                 285             


His Pro Glu Phe Ile Val Ser Val Lys Lys Glu Pro Leu Glu Asp Asp 
    290                 295                 300                 


Phe Ile Pro Glu Leu Gly Ile Ser Asn Leu Leu Ser Ser Ser His Cys 
305                 310                 315                 320 


Leu Arg Pro Pro Ser Cys Leu Leu Asp Ala His Ser Asp Cys Gly Tyr 
                325                 330                 335     


Glu Gly Ser Pro Ser Pro Phe Ser Asp Met Ser Ser Pro Leu Gly Thr 
            340                 345                 350         


Asp His Ser Trp Glu Asp Thr Phe Ala Asn Glu Leu Phe Pro Gln Leu 
        355                 360                 365             


Ile Ser Val 
    370     


<210>  15
<211>  1870
<212>  DNA
<213>  Rattus norvegicus

<400>  15
cgctggcgta gacgtttcct ggctatggtg gtggtggcag cggcgccgag cgcggcctcg       60

gcggccccca aagtgctact cctatctggt cagcccgcct ccggcggccg agcgctgccg      120

ctcatggttc cgggcccgcg agccgcaggg tcggaggcga gcgggacacc gcaggctcgc      180

aagcggcagc gcctcacgca cctgagcccg gaggagaaag cgctgcggag gaaactgaaa      240

aacagagtag cagcacagac tgcgcgagat agaaagaaag cccggatgag cgagctggag      300

cagcaagtgg tggatttgga agaagagaac cagaaactcc agctagaaaa tcagctttta      360

cgagagaaaa ctcatgggct tgtgattgag aaccaggagt taaggacacg cttggggatg      420

aatgccctgg ttactgaaga ggtctcagag gcagagtcca aggggaatgg agtaaggctg      480

gtggccgggt ctgctgagtc cgcagcactc agactacgtg cgcctctgca gcaggtgcag      540

gcccagttgt cacctcccca gaacatcttc ccatggattc tgacgctgtt gcctcttcag      600

attctgagtc tgatatcctt ttgggcattc tggacaagtt ggaccctgtc atgtttttca      660

aatgtccttc cccagagtct gctaatctgg aggaactccc agaggtctac ccagaaggac      720

ctagttcctt accagcctcc ctttctctgt cagtggggac ctcatcagcc aagctggaag      780

ccattaatga actcattcgt tttgaccatg tatacaccaa gcctctagtc ttagagatcc      840

cctctgagac agagagccaa actaatgtgg tagtgaaaat tgaggaagca cctctaagct      900

cttcagaaga ggatcaccct gaattcattg tctcagtgaa gaaagaacct ttggatgatg      960

acttcattcc cgagctgggc atctcaaacc tgctttcatc cagccattgt ctgagaccac     1020

cttcctgcct gctggatgct cacagtgact gtggatatga gggctcccct tctcccttca     1080

gcgacatgtc ttctccactt ggtacagacc actcctggga ggacactttt gccaacgaac     1140

ttttccccca gctgattagt gtctaaagcc acccaccact gggctccttc cctgatcatc     1200

acactgccta gaggatagca taggcctgtc tgcttcacta aaagccaaag tagaggctat     1260

ctggccttat aagaattcct ctaaagtatt tcaaacctct tagatgactt ccaagtattg     1320

tcttttgaca ctcagctgtc tgaggtcttc aaaggtattc caatactaca gcttttgaga     1380

ttctcattat cttaaaggtg gtagcatgct ctaaatcata gggaaagtca tctgacagtt     1440

atcgttcagc ctggctatgt agccgaggct aagctgaaac ttgtgaccct cttgacccca     1500

ctcccaagtg ctggacttta ccaggtgtgc agctccacac cggcctcttc acatgtcctg     1560

aagtagacat gagagtcacc agttctttct ctcctccccg ccccacaggt ttcttttgtt     1620

tccttctaca agcagagaaa cagcaacctg aggggcctgt ccttccttat gtccagttca     1680

agtgaagatc aagaatcttt gtaaaattat tggaaattta ctgtgtaaat gcttgatgga     1740

atcttcttgc tagtgtagct tctagaaggt gctttctcca tttatttaaa actacccatg     1800

caattaaaaa agcaacgcag catccccgtt gaatgatttt aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa                                                            1870


<210>  16
<211>  267
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Met Val Val Val Ala Ala Ala Pro Ser Ala Ala Ser Ala Ala Pro Lys 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Gly Gly Arg Ala Leu Pro 
            20                  25                  30          


Leu Met Val Pro Gly Pro Arg Ala Ala Gly Ser Glu Ala Ser Gly Thr 
        35                  40                  45              


Pro Gln Ala Arg Lys Arg Gln Arg Leu Thr His Leu Ser Pro Glu Glu 
    50                  55                  60                  


Lys Ala Leu Arg Arg Lys Leu Lys Asn Arg Val Ala Ala Gln Thr Ala 
65                  70                  75                  80  


Arg Asp Arg Lys Lys Ala Arg Met Ser Glu Leu Glu Gln Gln Val Val 
                85                  90                  95      


Asp Leu Glu Glu Glu Asn Gln Lys Leu Gln Leu Glu Asn Gln Leu Leu 
            100                 105                 110         


Arg Glu Lys Thr His Gly Leu Val Ile Glu Asn Gln Glu Leu Arg Thr 
        115                 120                 125             


Arg Leu Gly Met Asn Ala Leu Val Thr Glu Glu Val Ser Glu Ala Glu 
    130                 135                 140                 


Ser Lys Gly Asn Gly Val Arg Leu Val Ala Gly Ser Ala Glu Ser Ala 
145                 150                 155                 160 


Ala Leu Arg Leu Arg Ala Pro Leu Gln Gln Val Gln Ala Gln Leu Ser 
                165                 170                 175     


Pro Pro Gln Asn Ile Phe Pro Trp Ile Leu Thr Leu Leu Pro Leu Gln 
            180                 185                 190         


Ile Leu Ser Leu Ile Ser Phe Trp Ala Phe Trp Thr Ser Trp Thr Leu 
        195                 200                 205             


Ser Cys Phe Ser Asn Val Leu Pro Gln Ser Leu Leu Ile Trp Arg Asn 
    210                 215                 220                 


Ser Gln Arg Ser Thr Gln Lys Asp Leu Val Pro Tyr Gln Pro Pro Phe 
225                 230                 235                 240 


Leu Cys Gln Trp Gly Pro His Gln Pro Ser Trp Lys Pro Leu Met Asn 
                245                 250                 255     


Ser Phe Val Leu Thr Met Tyr Thr Pro Ser Leu 
            260                 265         


<210>  17
<211>  1844
<212>  DNA
<213>  Rattus norvegicus

<400>  17
cgctggcgta gacgtttcct ggctatggtg gtggtggcag cggcgccgag cgcggcctcg       60

gcggccccca aagtgctact cctatctggt cagcccgcct ccggcggccg agcgctgccg      120

ctcatggttc cgggcccgcg agccgcaggg tcggaggcga gcgggacacc gcaggctcgc      180

aagcggcagc gcctcacgca cctgagcccg gaggagaaag cgctgcggag gaaactgaaa      240

aacagagtag cagcacagac tgcgcgagat agaaagaaag cccggatgag cgagctggag      300

cagcaagtgg tggatttgga agaagagaac cagaaactcc agctagaaaa tcagctttta      360

cgagagaaaa ctcatgggct tgtgattgag aaccaggagt taaggacacg cttggggatg      420

aatgccctgg ttactgaaga ggtctcagag gcagagtcca aggggaatgg agtaaggctg      480

gtggccgggt ctgctgagtc cgcagcaggt gcaggcccag ttgtcacctc cccagaacat      540

cttcccatgg attctgacgc tgttgcctct tcagattctg agtctgatat ccttttgggc      600

attctggaca agttggaccc tgtcatgttt ttcaaatgtc cttccccaga gtctgctaat      660

ctggaggaac tcccagaggt ctacccagaa ggacctagtt ccttaccagc ctccctttct      720

ctgtcagtgg ggacctcatc agccaagctg gaagccatta atgaactcat tcgttttgac      780

catgtataca ccaagcctct agtcttagag atcccctctg agacagagag ccaaactaat      840

gtggtagtga aaattgagga agcacctcta agctcttcag aagaggatca ccctgaattc      900

attgtctcag tgaagaaaga acctttggat gatgacttca ttcccgagct gggcatctca      960

aacctgcttt catccagcca ttgtctgaga ccaccttcct gcctgctgga tgctcacagt     1020

gactgtggat atgagggctc cccttctccc ttcagcgaca tgtcttctcc acttggtaca     1080

gaccactcct gggaggacac ttttgccaac gaacttttcc cccagctgat tagtgtctaa     1140

agccacccac cactgggctc cttccctgat catcacactg cctagaggat agcataggcc     1200

tgtctgcttc actaaaagcc aaagtagagg ctatctggcc ttataagaat tcctctaaag     1260

tatttcaaac ctcttagatg acttccaagt attgtctttt gacactcagc tgtctgaggt     1320

cttcaaaggt attccaatac tacagctttt gagattctca ttatcttaaa ggtggtagca     1380

tgctctaaat catagggaaa gtcatctgac agttatcgtt cagcctggct atgtagccga     1440

ggctaagctg aaacttgtga ccctcttgac cccactccca agtgctggac tttaccaggt     1500

gtgcagctcc acaccggcct cttcacatgt cctgaagtag acatgagagt caccagttct     1560

ttctctcctc cccgccccac aggtttcttt tgtttccttc tacaagcaga gaaacagcaa     1620

cctgaggggc ctgtccttcc ttatgtccag ttcaagtgaa gatcaagaat ctttgtaaaa     1680

ttattggaaa tttactgtgt aaatgcttga tggaatcttc ttgctagtgt agcttctaga     1740

aggtgctttc tccatttatt taaaactacc catgcaatta aaaaagcaac gcagcatccc     1800

cgttgaatga ttttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      1844


<210>  18
<211>  371
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Val Val Val Ala Ala Ala Pro Ser Ala Ala Ser Ala Ala Pro Lys 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Gly Gly Arg Ala Leu Pro 
            20                  25                  30          


Leu Met Val Pro Gly Pro Arg Ala Ala Gly Ser Glu Ala Ser Gly Thr 
        35                  40                  45              


Pro Gln Ala Arg Lys Arg Gln Arg Leu Thr His Leu Ser Pro Glu Glu 
    50                  55                  60                  


Lys Ala Leu Arg Arg Lys Leu Lys Asn Arg Val Ala Ala Gln Thr Ala 
65                  70                  75                  80  


Arg Asp Arg Lys Lys Ala Arg Met Ser Glu Leu Glu Gln Gln Val Val 
                85                  90                  95      


Asp Leu Glu Glu Glu Asn Gln Lys Leu Gln Leu Glu Asn Gln Leu Leu 
            100                 105                 110         


Arg Glu Lys Thr His Gly Leu Val Ile Glu Asn Gln Glu Leu Arg Thr 
        115                 120                 125             


Arg Leu Gly Met Asn Ala Leu Val Thr Glu Glu Val Ser Glu Ala Glu 
    130                 135                 140                 


Ser Lys Gly Asn Gly Val Arg Leu Val Ala Gly Ser Ala Glu Ser Ala 
145                 150                 155                 160 


Ala Gly Ala Gly Pro Val Val Thr Ser Pro Glu His Leu Pro Met Asp 
                165                 170                 175     


Ser Asp Ala Val Ala Ser Ser Asp Ser Glu Ser Asp Ile Leu Leu Gly 
            180                 185                 190         


Ile Leu Asp Lys Leu Asp Pro Val Met Phe Phe Lys Cys Pro Ser Pro 
        195                 200                 205             


Glu Ser Ala Asn Leu Glu Glu Leu Pro Glu Val Tyr Pro Glu Gly Pro 
    210                 215                 220                 


Ser Ser Leu Pro Ala Ser Leu Ser Leu Ser Val Gly Thr Ser Ser Ala 
225                 230                 235                 240 


Lys Leu Glu Ala Ile Asn Glu Leu Ile Arg Phe Asp His Val Tyr Thr 
                245                 250                 255     


Lys Pro Leu Val Leu Glu Ile Pro Ser Glu Thr Glu Ser Gln Thr Asn 
            260                 265                 270         


Val Val Val Lys Ile Glu Glu Ala Pro Leu Ser Ser Ser Glu Glu Asp 
        275                 280                 285             


His Pro Glu Phe Ile Val Ser Val Lys Lys Glu Pro Leu Asp Asp Asp 
    290                 295                 300                 


Phe Ile Pro Glu Leu Gly Ile Ser Asn Leu Leu Ser Ser Ser His Cys 
305                 310                 315                 320 


Leu Arg Pro Pro Ser Cys Leu Leu Asp Ala His Ser Asp Cys Gly Tyr 
                325                 330                 335     


Glu Gly Ser Pro Ser Pro Phe Ser Asp Met Ser Ser Pro Leu Gly Thr 
            340                 345                 350         


Asp His Ser Trp Glu Asp Thr Phe Ala Asn Glu Leu Phe Pro Gln Leu 
        355                 360                 365             


Ile Ser Val 
    370     


<210>  19
<211>  4518
<212>  DNA
<213>  Homo sapiens

<400>  19
ggagtttatt cataacgcgc tctccaagta tacgtggcaa tgcgttgctg ggttatttta       60

atcattctag gcatcgtttt cctccttatg cctctatcat tcctccctat ctacactaac      120

atcccacgct ctgaacgcgc gcccattaat acccttcttt cctccactct ccctgggact      180

cttgatcaaa gcgcggccct ttccccagcc ttagcgaggc gccctgcagc ctggtacgcg      240

cgtggcgtgg cggtgggcgc gcagtgcgtt ctcggtgtgg agggcagctg ttccgcctgc      300

gatgatttat actcacagga caaggatgcg gtttgtcaaa cagtactgct acggaggagc      360

agcagagaaa gggagagggt ttgagaggga gcaaaagaaa atggtaggcg cgcgtagtta      420

attcatgcgg ctctcttact ctgtttacat cctagagcta gagtgctcgg ctgcccggct      480

gagtctcctc cccaccttcc ccaccctccc caccctcccc ataagcgccc ctcccgggtt      540

cccaaagcag agggcgtggg ggaaaagaaa aaagatcctc tctcgctaat ctccgcccac      600

cggcccttta taatgcgagg gtctggacgg ctgaggaccc ccgagctgtg ctgctcgcgg      660

ccgccaccgc cgggccccgg ccgtccctgg ctcccctcct gcctcgagaa gggcagggct      720

tctcagaggc ttggcgggaa aaagaacgga gggagggatc gcgctgagta taaaagccgg      780

ttttcggggc tttatctaac tcgctgtagt aattccagcg agaggcagag ggagcgagcg      840

ggcggccggc tagggtggaa gagccgggcg agcagagctg cgctgcgggc gtcctgggaa      900

gggagatccg gagcgaatag ggggcttcgc ctctggccca gccctcccgc tgatccccca      960

gccagcggtc cgcaaccctt gccgcatcca cgaaactttg cccatagcag cgggcgggca     1020

ctttgcactg gaacttacaa cacccgagca aggacgcgac tctcccgacg cggggaggct     1080

attctgccca tttggggaca cttccccgcc gctgccagga cccgcttctc tgaaaggctc     1140

tccttgcagc tgcttagacg ctggattttt ttcgggtagt ggaaaaccag cagcctcccg     1200

cgacgatgcc cctcaacgtt agcttcacca acaggaacta tgacctcgac tacgactcgg     1260

tgcagccgta tttctactgc gacgaggagg agaacttcta ccagcagcag cagcagagcg     1320

agctgcagcc cccggcgccc agcgaggata tctggaagaa attcgagctg ctgcccaccc     1380

cgcccctgtc ccctagccgc cgctccgggc tctgctcgcc ctcctacgtt gcggtcacac     1440

ccttctccct tcggggagac aacgacggcg gtggcgggag cttctccacg gccgaccagc     1500

tggagatggt gaccgagctg ctgggaggag acatggtgaa ccagagtttc atctgcgacc     1560

cggacgacga gaccttcatc aaaaacatca tcatccagga ctgtatgtgg agcggcttct     1620

cggccgccgc caagctcgtc tcagagaagc tggcctccta ccaggctgcg cgcaaagaca     1680

gcggcagccc gaaccccgcc cgcggccaca gcgtctgctc cacctccagc ttgtacctgc     1740

aggatctgag cgccgccgcc tcagagtgca tcgacccctc ggtggtcttc ccctaccctc     1800

tcaacgacag cagctcgccc aagtcctgcg cctcgcaaga ctccagcgcc ttctctccgt     1860

cctcggattc tctgctctcc tcgacggagt cctccccgca gggcagcccc gagcccctgg     1920

tgctccatga ggagacaccg cccaccacca gcagcgactc tgaggaggaa caagaagatg     1980

aggaagaaat cgatgttgtt tctgtggaaa agaggcaggc tcctggcaaa aggtcagagt     2040

ctggatcacc ttctgctgga ggccacagca aacctcctca cagcccactg gtcctcaaga     2100

ggtgccacgt ctccacacat cagcacaact acgcagcgcc tccctccact cggaaggact     2160

atcctgctgc caagagggtc aagttggaca gtgtcagagt cctgagacag atcagcaaca     2220

accgaaaatg caccagcccc aggtcctcgg acaccgagga gaatgtcaag aggcgaacac     2280

acaacgtctt ggagcgccag aggaggaacg agctaaaacg gagctttttt gccctgcgtg     2340

accagatccc ggagttggaa aacaatgaaa aggcccccaa ggtagttatc cttaaaaaag     2400

ccacagcata catcctgtcc gtccaagcag aggagcaaaa gctcatttct gaagaggact     2460

tgttgcggaa acgacgagaa cagttgaaac acaaacttga acagctacgg aactcttgtg     2520

cgtaaggaaa agtaaggaaa acgattcctt ctaacagaaa tgtcctgagc aatcacctat     2580

gaacttgttt caaatgcatg atcaaatgca acctcacaac cttggctgag tcttgagact     2640

gaaagattta gccataatgt aaactgcctc aaattggact ttgggcataa aagaactttt     2700

ttatgcttac catctttttt ttttctttaa cagatttgta tttaagaatt gtttttaaaa     2760

aattttaaga tttacacaat gtttctctgt aaatattgcc attaaatgta aataacttta     2820

ataaaacgtt tatagcagtt acacagaatt tcaatcctag tatatagtac ctagtattat     2880

aggtactata aaccctaatt ttttttattt aagtacattt tgctttttaa agttgatttt     2940

tttctattgt ttttagaaaa aataaaataa ctggcaaata tatcattgag ccaaatctta     3000

agttgtgaat gttttgtttc gtttcttccc cctcccaacc accaccatcc ctgtttgttt     3060

tcatcaattg ccccttcaga gggtggtctt aagaaaggca agagttttcc tctgttgaaa     3120

tgggtctggg ggccttaagg tctttaagtt cttggaggtt ctaagatgct tcctggagac     3180

tatgataaca gccagagttg acagttagaa ggaatggcag aaggcaggtg agaaggtgag     3240

aggtaggcaa aggagataca agaggtcaaa ggtagcagtt aagtacacaa agaggcataa     3300

ggactgggga gttgggagga aggtgaggaa gaaactcctg ttactttagt taaccagtgc     3360

cagtcccctg ctcactccaa acccaggaat tctgcccagt tgatggggac acggtgggaa     3420

ccagcttctg ctgccttcac aaccaggcgc cagtcctgtc catgggttat ctcgcaaacc     3480

ccagaggatc tctgggagga atgctactat taaccctatt tcacaaacaa ggaaatagaa     3540

gagctcaaag aggttatgta acttatctgt agccacgcag ataatacaaa gcagcaatct     3600

ggacccattc tgttcaaaac acttaaccct tcgctatcat gccttggttc atctgggtct     3660

aatgtgctga gatcaagaag gtttaggacc taatggacag actcaagtca taacaatgct     3720

aagctctatt tgtgtcccaa gcactcctaa gcattttatc cctaactcta catcaacccc     3780

atgaaggaga tactgttgat ttccccatat tagaagtaga gagggaagct gaggcacaca     3840

aagactcatc cacatgccca agattcactg atagggaaaa gtggaagcga gatttgaacc     3900

caggctgttt actcctaacc tgtccaagcc acctctcaga cgacggtagg aatcagctgg     3960

ctgcttgtga gtacaggagt tacagtccag tgggttatgt tttttaagtc tcaacatcta     4020

agcctggtca ggcatcagtt cccctttttt tgtgatttat tttgttttta ttttgttgtt     4080

cattgtttaa tttttccttt tacaatgaga aggtcaccat cttgactcct accttagcca     4140

tttgttgaat cagactcatg acggctcctg ggaagaagcc agttcagatc ataaaataaa     4200

acatatttat tctttgtcat gggagtcatt attttagaaa ctacaaactc tccttgcttc     4260

catccttttt tacatactca tgacacatgc tcatcctgag tccttgaaaa ggtatttttg     4320

aacatgtgta ttaattataa gcctctgaaa acctatggcc caaaccagaa atgatgttga     4380

ttatataggt aaatgaagga tgctattgct gttctaatta cctcattgtc tcagtctcaa     4440

agtaggtctt cagctccctg tactttggga ttttaatcta ccaccaccca taaatcaata     4500

aataattact ttctttga                                                   4518


<210>  20
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  21
<211>  4515
<212>  DNA
<213>  Homo sapiens

<400>  21
ggagtttatt cataacgcgc tctccaagta tacgtggcaa tgcgttgctg ggttatttta       60

atcattctag gcatcgtttt cctccttatg cctctatcat tcctccctat ctacactaac      120

atcccacgct ctgaacgcgc gcccattaat acccttcttt cctccactct ccctgggact      180

cttgatcaaa gcgcggccct ttccccagcc ttagcgaggc gccctgcagc ctggtacgcg      240

cgtggcgtgg cggtgggcgc gcagtgcgtt ctcggtgtgg agggcagctg ttccgcctgc      300

gatgatttat actcacagga caaggatgcg gtttgtcaaa cagtactgct acggaggagc      360

agcagagaaa gggagagggt ttgagaggga gcaaaagaaa atggtaggcg cgcgtagtta      420

attcatgcgg ctctcttact ctgtttacat cctagagcta gagtgctcgg ctgcccggct      480

gagtctcctc cccaccttcc ccaccctccc caccctcccc ataagcgccc ctcccgggtt      540

cccaaagcag agggcgtggg ggaaaagaaa aaagatcctc tctcgctaat ctccgcccac      600

cggcccttta taatgcgagg gtctggacgg ctgaggaccc ccgagctgtg ctgctcgcgg      660

ccgccaccgc cgggccccgg ccgtccctgg ctcccctcct gcctcgagaa gggcagggct      720

tctcagaggc ttggcgggaa aaagaacgga gggagggatc gcgctgagta taaaagccgg      780

ttttcggggc tttatctaac tcgctgtagt aattccagcg agaggcagag ggagcgagcg      840

ggcggccggc tagggtggaa gagccgggcg agcagagctg cgctgcgggc gtcctgggaa      900

gggagatccg gagcgaatag ggggcttcgc ctctggccca gccctcccgc tgatccccca      960

gccagcggtc cgcaaccctt gccgcatcca cgaaactttg cccatagcag cgggcgggca     1020

ctttgcactg gaacttacaa cacccgagca aggacgcgac tctcccgacg cggggaggct     1080

attctgccca tttggggaca cttccccgcc gctgccagga cccgcttctc tgaaaggctc     1140

tccttgcagc tgcttagacg ctggattttt ttcgggtagt ggaaaaccag cctcccgcga     1200

cgatgcccct caacgttagc ttcaccaaca ggaactatga cctcgactac gactcggtgc     1260

agccgtattt ctactgcgac gaggaggaga acttctacca gcagcagcag cagagcgagc     1320

tgcagccccc ggcgcccagc gaggatatct ggaagaaatt cgagctgctg cccaccccgc     1380

ccctgtcccc tagccgccgc tccgggctct gctcgccctc ctacgttgcg gtcacaccct     1440

tctcccttcg gggagacaac gacggcggtg gcgggagctt ctccacggcc gaccagctgg     1500

agatggtgac cgagctgctg ggaggagaca tggtgaacca gagtttcatc tgcgacccgg     1560

acgacgagac cttcatcaaa aacatcatca tccaggactg tatgtggagc ggcttctcgg     1620

ccgccgccaa gctcgtctca gagaagctgg cctcctacca ggctgcgcgc aaagacagcg     1680

gcagcccgaa ccccgcccgc ggccacagcg tctgctccac ctccagcttg tacctgcagg     1740

atctgagcgc cgccgcctca gagtgcatcg acccctcggt ggtcttcccc taccctctca     1800

acgacagcag ctcgcccaag tcctgcgcct cgcaagactc cagcgccttc tctccgtcct     1860

cggattctct gctctcctcg acggagtcct ccccgcaggg cagccccgag cccctggtgc     1920

tccatgagga gacaccgccc accaccagca gcgactctga ggaggaacaa gaagatgagg     1980

aagaaatcga tgttgtttct gtggaaaaga ggcaggctcc tggcaaaagg tcagagtctg     2040

gatcaccttc tgctggaggc cacagcaaac ctcctcacag cccactggtc ctcaagaggt     2100

gccacgtctc cacacatcag cacaactacg cagcgcctcc ctccactcgg aaggactatc     2160

ctgctgccaa gagggtcaag ttggacagtg tcagagtcct gagacagatc agcaacaacc     2220

gaaaatgcac cagccccagg tcctcggaca ccgaggagaa tgtcaagagg cgaacacaca     2280

acgtcttgga gcgccagagg aggaacgagc taaaacggag cttttttgcc ctgcgtgacc     2340

agatcccgga gttggaaaac aatgaaaagg cccccaaggt agttatcctt aaaaaagcca     2400

cagcatacat cctgtccgtc caagcagagg agcaaaagct catttctgaa gaggacttgt     2460

tgcggaaacg acgagaacag ttgaaacaca aacttgaaca gctacggaac tcttgtgcgt     2520

aaggaaaagt aaggaaaacg attccttcta acagaaatgt cctgagcaat cacctatgaa     2580

cttgtttcaa atgcatgatc aaatgcaacc tcacaacctt ggctgagtct tgagactgaa     2640

agatttagcc ataatgtaaa ctgcctcaaa ttggactttg ggcataaaag aactttttta     2700

tgcttaccat cttttttttt tctttaacag atttgtattt aagaattgtt tttaaaaaat     2760

tttaagattt acacaatgtt tctctgtaaa tattgccatt aaatgtaaat aactttaata     2820

aaacgtttat agcagttaca cagaatttca atcctagtat atagtaccta gtattatagg     2880

tactataaac cctaattttt tttatttaag tacattttgc tttttaaagt tgattttttt     2940

ctattgtttt tagaaaaaat aaaataactg gcaaatatat cattgagcca aatcttaagt     3000

tgtgaatgtt ttgtttcgtt tcttccccct cccaaccacc accatccctg tttgttttca     3060

tcaattgccc cttcagaggg tggtcttaag aaaggcaaga gttttcctct gttgaaatgg     3120

gtctgggggc cttaaggtct ttaagttctt ggaggttcta agatgcttcc tggagactat     3180

gataacagcc agagttgaca gttagaagga atggcagaag gcaggtgaga aggtgagagg     3240

taggcaaagg agatacaaga ggtcaaaggt agcagttaag tacacaaaga ggcataagga     3300

ctggggagtt gggaggaagg tgaggaagaa actcctgtta ctttagttaa ccagtgccag     3360

tcccctgctc actccaaacc caggaattct gcccagttga tggggacacg gtgggaacca     3420

gcttctgctg ccttcacaac caggcgccag tcctgtccat gggttatctc gcaaacccca     3480

gaggatctct gggaggaatg ctactattaa ccctatttca caaacaagga aatagaagag     3540

ctcaaagagg ttatgtaact tatctgtagc cacgcagata atacaaagca gcaatctgga     3600

cccattctgt tcaaaacact taacccttcg ctatcatgcc ttggttcatc tgggtctaat     3660

gtgctgagat caagaaggtt taggacctaa tggacagact caagtcataa caatgctaag     3720

ctctatttgt gtcccaagca ctcctaagca ttttatccct aactctacat caaccccatg     3780

aaggagatac tgttgatttc cccatattag aagtagagag ggaagctgag gcacacaaag     3840

actcatccac atgcccaaga ttcactgata gggaaaagtg gaagcgagat ttgaacccag     3900

gctgtttact cctaacctgt ccaagccacc tctcagacga cggtaggaat cagctggctg     3960

cttgtgagta caggagttac agtccagtgg gttatgtttt ttaagtctca acatctaagc     4020

ctggtcaggc atcagttccc ctttttttgt gatttatttt gtttttattt tgttgttcat     4080

tgtttaattt ttccttttac aatgagaagg tcaccatctt gactcctacc ttagccattt     4140

gttgaatcag actcatgacg gctcctggga agaagccagt tcagatcata aaataaaaca     4200

tatttattct ttgtcatggg agtcattatt ttagaaacta caaactctcc ttgcttccat     4260

ccttttttac atactcatga cacatgctca tcctgagtcc ttgaaaaggt atttttgaac     4320

atgtgtatta attataagcc tctgaaaacc tatggcccaa accagaaatg atgttgatta     4380

tataggtaaa tgaaggatgc tattgctgtt ctaattacct cattgtctca gtctcaaagt     4440

aggtcttcag ctccctgtac tttgggattt taatctacca ccacccataa atcaataaat     4500

aattactttc tttga                                                      4515


<210>  22
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Phe Phe Arg Val Val Glu Asn Gln Pro Pro Ala Thr Met Pro 
1               5                   10                  15      


Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp Ser 
            20                  25                  30          


Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln Gln 
        35                  40                  45              


Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile Trp 
    50                  55                  60                  


Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg Arg 
65                  70                  75                  80  


Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser Leu 
                85                  90                  95      


Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp Gln 
            100                 105                 110         


Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln Ser 
        115                 120                 125             


Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile Ile 
    130                 135                 140                 


Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val Ser 
145                 150                 155                 160 


Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser Pro 
                165                 170                 175     


Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr Leu 
            180                 185                 190         


Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val Val 
        195                 200                 205             


Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala Ser 
    210                 215                 220                 


Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser Ser 
225                 230                 235                 240 


Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His Glu 
                245                 250                 255     


Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu Asp 
            260                 265                 270         


Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro Gly 
        275                 280                 285             


Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys Pro 
    290                 295                 300                 


Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His Gln 
305                 310                 315                 320 


His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala Ala 
                325                 330                 335     


Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser Asn 
            340                 345                 350         


Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn Val 
        355                 360                 365             


Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu 
    370                 375                 380                 


Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu Asn 
385                 390                 395                 400 


Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala Tyr 
                405                 410                 415     


Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln Leu 
        435                 440                 445             


Arg Asn Ser Cys Ala 
    450             


<210>  23
<211>  2399
<212>  DNA
<213>  Mus musculus

<400>  23
cccgcccacc cgccctttat attccggggg tctgcgcggc cgaggacccc tgggctgcgc       60

tgctctcagc tgccgggtcc gactcgcctc actcagctcc cctcctgcct cctgaagggc      120

agggcttcgc cgacgcttgg cgggaaaaag aagggagggg agggatcctg agtcgcagta      180

taaaagaagc ttttcgggcg tttttttctg actcgctgta gtaattccag cgagagacag      240

agggagtgag cggacggttg gaagagccgt gtgtgcagag ccgcgctccg gggcgaccta      300

agaaggcagc tctggagtga gaggggcttt gcctccgagc ctgccgccca ctctccccaa      360

ccctgcgact gacccaacat cagcggccgc aaccctcgcc gccgctggga aactttgccc      420

attgcagcgg gcagacactt ctcactggaa cttacaatct gcgagccagg acaggactcc      480

ccaggctccg gggagggaat ttttgtctat ttggggacag tgttctctgc ctctgcccgc      540

gatcagctct cctgaaaaga gctcctcgag ctgtttgaag gctggatttc ctttgggcgt      600

tggaaacccc gcagacagcc acgacgatgc ccctcaacgt gaacttcacc aacaggaact      660

atgacctcga ctacgactcc gtacagccct atttcatctg cgacgaggaa gagaatttct      720

atcaccagca acagcagagc gagctgcagc cgcccgcgcc cagtgaggat atctggaaga      780

aattcgagct gcttcccacc ccgcccctgt ccccgagccg ccgctccggg ctctgctctc      840

catcctatgt tgcggtcgct acgtccttct ccccaaggga agacgatgac ggcggcggtg      900

gcaacttctc caccgccgat cagctggaga tgatgaccga gttacttgga ggagacatgg      960

tgaaccagag cttcatctgc gatcctgacg acgagacctt catcaagaac atcatcatcc     1020

aggactgtat gtggagcggt ttctcagccg ctgccaagct ggtctcggag aagctggcct     1080

cctaccaggc tgcgcgcaaa gacagcacca gcctgagccc cgcccgcggg cacagcgtct     1140

gctccacctc cagcctgtac ctgcaggacc tcaccgccgc cgcgtccgag tgcattgacc     1200

cctcagtggt ctttccctac ccgctcaacg acagcagctc gcccaaatcc tgtacctcgt     1260

ccgattccac ggccttctct ccttcctcgg actcgctgct gtcctccgag tcctccccac     1320

gggccagccc tgagccccta gtgctgcatg aggagacacc gcccaccacc agcagcgact     1380

ctgaagaaga gcaagaagat gaggaagaaa ttgatgtggt gtctgtggag aagaggcaaa     1440

cccctgccaa gaggtcggag tcgggctcat ctccatcccg aggccacagc aaacctccgc     1500

acagcccact ggtcctcaag aggtgccacg tctccactca ccagcacaac tacgccgcac     1560

ccccctccac aaggaaggac tatccagctg ccaagagggc caagttggac agtggcaggg     1620

tcctgaagca gatcagcaac aaccgcaagt gctccagccc caggtcctca gacacggagg     1680

aaaacgacaa gaggcggaca cacaacgtct tggaacgtca gaggaggaac gagctgaagc     1740

gcagcttttt tgccctgcgt gaccagatcc ctgaattgga aaacaacgaa aaggccccca     1800

aggtagtgat cctcaaaaaa gccaccgcct acatcctgtc cattcaagca gacgagcaca     1860

agctcacctc tgaaaaggac ttattgagga aacgacgaga acagttgaaa cacaaactcg     1920

aacagcttcg aaactctggt gcataaactg acctaactcg aggaggagct ggaatctctc     1980

gtgagagtaa ggagaacggt tccttctgac agaactgatg cgctggaatt aaaatgcatg     2040

ctcaaagcct aacctcacaa ccttggctgg ggctttggga ctgtaagctt cagccataat     2100

tttaactgcc tcaaacttaa atagtataaa agaacttttt tttatgcttc ccatcttttt     2160

tctttttcct tttaacagat ttgtatttaa ttgttttttt aaaaaaatct taaaatctat     2220

ccaattttcc catgtaaata gggccttgaa atgtaaataa ctttaataaa acgtttataa     2280

cagttacaaa agattttaag acatgtacca taattttttt tatttaaaga cattttcatt     2340

tttaaagttg atttttttct attgttttta gaaaaaaata aaataattgg aaaaaatac      2399


<210>  24
<211>  454
<212>  PRT
<213>  Mus musculus

<400>  24

Met Asp Phe Leu Trp Ala Leu Glu Thr Pro Gln Thr Ala Thr Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Asn Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Ile Cys Asp Glu Glu Glu Asn Phe Tyr His 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Ala Thr Ser Phe 
                85                  90                  95      


Ser Pro Arg Glu Asp Asp Asp Gly Gly Gly Gly Asn Phe Ser Thr Ala 
            100                 105                 110         


Asp Gln Leu Glu Met Met Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
        115                 120                 125             


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
    130                 135                 140                 


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
145                 150                 155                 160 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Thr 
                165                 170                 175     


Ser Leu Ser Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
            180                 185                 190         


Tyr Leu Gln Asp Leu Thr Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
        195                 200                 205             


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
    210                 215                 220                 


Thr Ser Ser Asp Ser Thr Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
225                 230                 235                 240 


Ser Ser Glu Ser Ser Pro Arg Ala Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Thr Pro 
        275                 280                 285             


Ala Lys Arg Ser Glu Ser Gly Ser Ser Pro Ser Arg Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Ala Lys Leu Asp Ser Gly Arg Val Leu Lys Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Ser Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Asp Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Ile Gln Ala Asp Glu His Lys Leu Thr Ser Glu Lys 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Gly Ala 
    450                 


<210>  25
<211>  2399
<212>  DNA
<213>  Mus musculus

<400>  25
cccgcccacc cgccctttat attccggggg tctgcgcggc cgaggacccc tgggctgcgc       60

tgctctcagc tgccgggtcc gactcgcctc actcagctcc cctcctgcct cctgaagggc      120

agggcttcgc cgacgcttgg cgggaaaaag aagggagggg agggatcctg agtcgcagta      180

taaaagaagc ttttcgggcg tttttttctg actcgctgta gtaattccag cgagagacag      240

agggagtgag cggacggttg gaagagccgt gtgtgcagag ccgcgctccg gggcgaccta      300

agaaggcagc tctggagtga gaggggcttt gcctccgagc ctgccgccca ctctccccaa      360

ccctgcgact gacccaacat cagcggccgc aaccctcgcc gccgctggga aactttgccc      420

attgcagcgg gcagacactt ctcactggaa cttacaatct gcgagccagg acaggactcc      480

ccaggctccg gggagggaat ttttgtctat ttggggacag tgttctctgc ctctgcccgc      540

gatcagctct cctgaaaaga gctcctcgag ctgtttgaag gctggatttc ctttgggcgt      600

tggaaacccc gcagacagcc acgacgatgc ccctcaacgt gaacttcacc aacaggaact      660

atgacctcga ctacgactcc gtacagccct atttcatctg cgacgaggaa gagaatttct      720

atcaccagca acagcagagc gagctgcagc cgcccgcgcc cagtgaggat atctggaaga      780

aattcgagct gcttcccacc ccgcccctgt ccccgagccg ccgctccggg ctctgctctc      840

catcctatgt tgcggtcgct acgtccttct ccccaaggga agacgatgac ggcggcggtg      900

gcaacttctc caccgccgat cagctggaga tgatgaccga gttacttgga ggagacatgg      960

tgaaccagag cttcatctgc gatcctgacg acgagacctt catcaagaac atcatcatcc     1020

aggactgtat gtggagcggt ttctcagccg ctgccaagct ggtctcggag aagctggcct     1080

cctaccaggc tgcgcgcaaa gacagcacca gcctgagccc cgcccgcggg cacagcgtct     1140

gctccacctc cagcctgtac ctgcaggacc tcaccgccgc cgcgtccgag tgcattgacc     1200

cctcagtggt ctttccctac ccgctcaacg acagcagctc gcccaaatcc tgtacctcgt     1260

ccgattccac ggccttctct ccttcctcgg actcgctgct gtcctccgag tcctccccac     1320

gggccagccc tgagccccta gtgctgcatg aggagacacc gcccaccacc agcagcgact     1380

ctgaagaaga gcaagaagat gaggaagaaa ttgatgtggt gtctgtggag aagaggcaaa     1440

cccctgccaa gaggtcggag tcgggctcat ctccatcccg aggccacagc aaacctccgc     1500

acagcccact ggtcctcaag aggtgccacg tctccactca ccagcacaac tacgccgcac     1560

ccccctccac aaggaaggac tatccagctg ccaagagggc caagttggac agtggcaggg     1620

tcctgaagca gatcagcaac aaccgcaagt gctccagccc caggtcctca gacacggagg     1680

aaaacgacaa gaggcggaca cacaacgtct tggaacgtca gaggaggaac gagctgaagc     1740

gcagcttttt tgccctgcgt gaccagatcc ctgaattgga aaacaacgaa aaggccccca     1800

aggtagtgat cctcaaaaaa gccaccgcct acatcctgtc cattcaagca gacgagcaca     1860

agctcacctc tgaaaaggac ttattgagga aacgacgaga acagttgaaa cacaaactcg     1920

aacagcttcg aaactctggt gcataaactg acctaactcg aggaggagct ggaatctctc     1980

gtgagagtaa ggagaacggt tccttctgac agaactgatg cgctggaatt aaaatgcatg     2040

ctcaaagcct aacctcacaa ccttggctgg ggctttggga ctgtaagctt cagccataat     2100

tttaactgcc tcaaacttaa atagtataaa agaacttttt tttatgcttc ccatcttttt     2160

tctttttcct tttaacagat ttgtatttaa ttgttttttt aaaaaaatct taaaatctat     2220

ccaattttcc catgtaaata gggccttgaa atgtaaataa ctttaataaa acgtttataa     2280

cagttacaaa agattttaag acatgtacca taattttttt tatttaaaga cattttcatt     2340

tttaaagttg atttttttct attgttttta gaaaaaaata aaataattgg aaaaaatac      2399


<210>  26
<211>  439
<212>  PRT
<213>  Mus musculus

<400>  26

Met Pro Leu Asn Val Asn Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Ile Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


His Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Ala Thr Ser 
65                  70                  75                  80  


Phe Ser Pro Arg Glu Asp Asp Asp Gly Gly Gly Gly Asn Phe Ser Thr 
                85                  90                  95      


Ala Asp Gln Leu Glu Met Met Thr Glu Leu Leu Gly Gly Asp Met Val 
            100                 105                 110         


Asn Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn 
        115                 120                 125             


Ile Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys 
    130                 135                 140                 


Leu Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser 
145                 150                 155                 160 


Thr Ser Leu Ser Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser 
                165                 170                 175     


Leu Tyr Leu Gln Asp Leu Thr Ala Ala Ala Ser Glu Cys Ile Asp Pro 
            180                 185                 190         


Ser Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser 
        195                 200                 205             


Cys Thr Ser Ser Asp Ser Thr Ala Phe Ser Pro Ser Ser Asp Ser Leu 
    210                 215                 220                 


Leu Ser Ser Glu Ser Ser Pro Arg Ala Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Thr 
            260                 265                 270         


Pro Ala Lys Arg Ser Glu Ser Gly Ser Ser Pro Ser Arg Gly His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Ala Lys Leu Asp Ser Gly Arg Val Leu Lys Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Ser Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Asp Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Ile Gln Ala Asp Glu His Lys Leu Thr Ser Glu 
                405                 410                 415     


Lys Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
            420                 425                 430         


Gln Leu Arg Asn Ser Gly Ala 
        435                 


<210>  27
<211>  2396
<212>  DNA
<213>  Mus musculus

<400>  27
cccgcccacc cgccctttat attccggggg tctgcgcggc cgaggacccc tgggctgcgc       60

tgctctcagc tgccgggtcc gactcgcctc actcagctcc cctcctgcct cctgaagggc      120

agggcttcgc cgacgcttgg cgggaaaaag aagggagggg agggatcctg agtcgcagta      180

taaaagaagc ttttcgggcg tttttttctg actcgctgta gtaattccag cgagagacag      240

agggagtgag cggacggttg gaagagccgt gtgtgcagag ccgcgctccg gggcgaccta      300

agaaggcagc tctggagtga gaggggcttt gcctccgagc ctgccgccca ctctccccaa      360

ccctgcgact gacccaacat cagcggccgc aaccctcgcc gccgctggga aactttgccc      420

attgcagcgg gcagacactt ctcactggaa cttacaatct gcgagccagg acaggactcc      480

ccaggctccg gggagggaat ttttgtctat ttggggacag tgttctctgc ctctgcccgc      540

gatcagctct cctgaaaaga gctcctcgag ctgtttgaag gctggatttc ctttgggcgt      600

tggaaacccc gacagccacg acgatgcccc tcaacgtgaa cttcaccaac aggaactatg      660

acctcgacta cgactccgta cagccctatt tcatctgcga cgaggaagag aatttctatc      720

accagcaaca gcagagcgag ctgcagccgc ccgcgcccag tgaggatatc tggaagaaat      780

tcgagctgct tcccaccccg cccctgtccc cgagccgccg ctccgggctc tgctctccat      840

cctatgttgc ggtcgctacg tccttctccc caagggaaga cgatgacggc ggcggtggca      900

acttctccac cgccgatcag ctggagatga tgaccgagtt acttggagga gacatggtga      960

accagagctt catctgcgat cctgacgacg agaccttcat caagaacatc atcatccagg     1020

actgtatgtg gagcggtttc tcagccgctg ccaagctggt ctcggagaag ctggcctcct     1080

accaggctgc gcgcaaagac agcaccagcc tgagccccgc ccgcgggcac agcgtctgct     1140

ccacctccag cctgtacctg caggacctca ccgccgccgc gtccgagtgc attgacccct     1200

cagtggtctt tccctacccg ctcaacgaca gcagctcgcc caaatcctgt acctcgtccg     1260

attccacggc cttctctcct tcctcggact cgctgctgtc ctccgagtcc tccccacggg     1320

ccagccctga gcccctagtg ctgcatgagg agacaccgcc caccaccagc agcgactctg     1380

aagaagagca agaagatgag gaagaaattg atgtggtgtc tgtggagaag aggcaaaccc     1440

ctgccaagag gtcggagtcg ggctcatctc catcccgagg ccacagcaaa cctccgcaca     1500

gcccactggt cctcaagagg tgccacgtct ccactcacca gcacaactac gccgcacccc     1560

cctccacaag gaaggactat ccagctgcca agagggccaa gttggacagt ggcagggtcc     1620

tgaagcagat cagcaacaac cgcaagtgct ccagccccag gtcctcagac acggaggaaa     1680

acgacaagag gcggacacac aacgtcttgg aacgtcagag gaggaacgag ctgaagcgca     1740

gcttttttgc cctgcgtgac cagatccctg aattggaaaa caacgaaaag gcccccaagg     1800

tagtgatcct caaaaaagcc accgcctaca tcctgtccat tcaagcagac gagcacaagc     1860

tcacctctga aaaggactta ttgaggaaac gacgagaaca gttgaaacac aaactcgaac     1920

agcttcgaaa ctctggtgca taaactgacc taactcgagg aggagctgga atctctcgtg     1980

agagtaagga gaacggttcc ttctgacaga actgatgcgc tggaattaaa atgcatgctc     2040

aaagcctaac ctcacaacct tggctggggc tttgggactg taagcttcag ccataatttt     2100

aactgcctca aacttaaata gtataaaaga actttttttt atgcttccca tcttttttct     2160

ttttcctttt aacagatttg tatttaattg tttttttaaa aaaatcttaa aatctatcca     2220

attttcccat gtaaataggg ccttgaaatg taaataactt taataaaacg tttataacag     2280

ttacaaaaga ttttaagaca tgtaccataa ttttttttat ttaaagacat tttcattttt     2340

aaagttgatt tttttctatt gtttttagaa aaaaataaaa taattggaaa aaatac         2396


<210>  28
<211>  439
<212>  PRT
<213>  Mus musculus

<400>  28

Met Pro Leu Asn Val Asn Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Ile Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


His Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Ala Thr Ser 
65                  70                  75                  80  


Phe Ser Pro Arg Glu Asp Asp Asp Gly Gly Gly Gly Asn Phe Ser Thr 
                85                  90                  95      


Ala Asp Gln Leu Glu Met Met Thr Glu Leu Leu Gly Gly Asp Met Val 
            100                 105                 110         


Asn Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn 
        115                 120                 125             


Ile Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys 
    130                 135                 140                 


Leu Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser 
145                 150                 155                 160 


Thr Ser Leu Ser Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser 
                165                 170                 175     


Leu Tyr Leu Gln Asp Leu Thr Ala Ala Ala Ser Glu Cys Ile Asp Pro 
            180                 185                 190         


Ser Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser 
        195                 200                 205             


Cys Thr Ser Ser Asp Ser Thr Ala Phe Ser Pro Ser Ser Asp Ser Leu 
    210                 215                 220                 


Leu Ser Ser Glu Ser Ser Pro Arg Ala Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Thr 
            260                 265                 270         


Pro Ala Lys Arg Ser Glu Ser Gly Ser Ser Pro Ser Arg Gly His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Ala Lys Leu Asp Ser Gly Arg Val Leu Lys Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Ser Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Asp Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Ile Gln Ala Asp Glu His Lys Leu Thr Ser Glu 
                405                 410                 415     


Lys Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
            420                 425                 430         


Gln Leu Arg Asn Ser Gly Ala 
        435                 


<210>  29
<211>  2396
<212>  DNA
<213>  Mus musculus

<400>  29
cccgcccacc cgccctttat attccggggg tctgcgcggc cgaggacccc tgggctgcgc       60

tgctctcagc tgccgggtcc gactcgcctc actcagctcc cctcctgcct cctgaagggc      120

agggcttcgc cgacgcttgg cgggaaaaag aagggagggg agggatcctg agtcgcagta      180

taaaagaagc ttttcgggcg tttttttctg actcgctgta gtaattccag cgagagacag      240

agggagtgag cggacggttg gaagagccgt gtgtgcagag ccgcgctccg gggcgaccta      300

agaaggcagc tctggagtga gaggggcttt gcctccgagc ctgccgccca ctctccccaa      360

ccctgcgact gacccaacat cagcggccgc aaccctcgcc gccgctggga aactttgccc      420

attgcagcgg gcagacactt ctcactggaa cttacaatct gcgagccagg acaggactcc      480

ccaggctccg gggagggaat ttttgtctat ttggggacag tgttctctgc ctctgcccgc      540

gatcagctct cctgaaaaga gctcctcgag ctgtttgaag gctggatttc ctttgggcgt      600

tggaaacccc gacagccacg acgatgcccc tcaacgtgaa cttcaccaac aggaactatg      660

acctcgacta cgactccgta cagccctatt tcatctgcga cgaggaagag aatttctatc      720

accagcaaca gcagagcgag ctgcagccgc ccgcgcccag tgaggatatc tggaagaaat      780

tcgagctgct tcccaccccg cccctgtccc cgagccgccg ctccgggctc tgctctccat      840

cctatgttgc ggtcgctacg tccttctccc caagggaaga cgatgacggc ggcggtggca      900

acttctccac cgccgatcag ctggagatga tgaccgagtt acttggagga gacatggtga      960

accagagctt catctgcgat cctgacgacg agaccttcat caagaacatc atcatccagg     1020

actgtatgtg gagcggtttc tcagccgctg ccaagctggt ctcggagaag ctggcctcct     1080

accaggctgc gcgcaaagac agcaccagcc tgagccccgc ccgcgggcac agcgtctgct     1140

ccacctccag cctgtacctg caggacctca ccgccgccgc gtccgagtgc attgacccct     1200

cagtggtctt tccctacccg ctcaacgaca gcagctcgcc caaatcctgt acctcgtccg     1260

attccacggc cttctctcct tcctcggact cgctgctgtc ctccgagtcc tccccacggg     1320

ccagccctga gcccctagtg ctgcatgagg agacaccgcc caccaccagc agcgactctg     1380

aagaagagca agaagatgag gaagaaattg atgtggtgtc tgtggagaag aggcaaaccc     1440

ctgccaagag gtcggagtcg ggctcatctc catcccgagg ccacagcaaa cctccgcaca     1500

gcccactggt cctcaagagg tgccacgtct ccactcacca gcacaactac gccgcacccc     1560

cctccacaag gaaggactat ccagctgcca agagggccaa gttggacagt ggcagggtcc     1620

tgaagcagat cagcaacaac cgcaagtgct ccagccccag gtcctcagac acggaggaaa     1680

acgacaagag gcggacacac aacgtcttgg aacgtcagag gaggaacgag ctgaagcgca     1740

gcttttttgc cctgcgtgac cagatccctg aattggaaaa caacgaaaag gcccccaagg     1800

tagtgatcct caaaaaagcc accgcctaca tcctgtccat tcaagcagac gagcacaagc     1860

tcacctctga aaaggactta ttgaggaaac gacgagaaca gttgaaacac aaactcgaac     1920

agcttcgaaa ctctggtgca taaactgacc taactcgagg aggagctgga atctctcgtg     1980

agagtaagga gaacggttcc ttctgacaga actgatgcgc tggaattaaa atgcatgctc     2040

aaagcctaac ctcacaacct tggctggggc tttgggactg taagcttcag ccataatttt     2100

aactgcctca aacttaaata gtataaaaga actttttttt atgcttccca tcttttttct     2160

ttttcctttt aacagatttg tatttaattg tttttttaaa aaaatcttaa aatctatcca     2220

attttcccat gtaaataggg ccttgaaatg taaataactt taataaaacg tttataacag     2280

ttacaaaaga ttttaagaca tgtaccataa ttttttttat ttaaagacat tttcattttt     2340

aaagttgatt tttttctatt gtttttagaa aaaaataaaa taattggaaa aaatac         2396


<210>  30
<211>  453
<212>  PRT
<213>  Mus musculus

<400>  30

Met Asp Phe Leu Trp Ala Leu Glu Thr Pro Thr Ala Thr Thr Met Pro 
1               5                   10                  15      


Leu Asn Val Asn Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp Ser 
            20                  25                  30          


Val Gln Pro Tyr Phe Ile Cys Asp Glu Glu Glu Asn Phe Tyr His Gln 
        35                  40                  45              


Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile Trp 
    50                  55                  60                  


Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg Arg 
65                  70                  75                  80  


Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Ala Thr Ser Phe Ser 
                85                  90                  95      


Pro Arg Glu Asp Asp Asp Gly Gly Gly Gly Asn Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Met Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Thr Ser 
                165                 170                 175     


Leu Ser Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Thr Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Thr 
    210                 215                 220                 


Ser Ser Asp Ser Thr Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Glu Ser Ser Pro Arg Ala Ser Pro Glu Pro Leu Val Leu His Glu 
                245                 250                 255     


Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu Asp 
            260                 265                 270         


Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Thr Pro Ala 
        275                 280                 285             


Lys Arg Ser Glu Ser Gly Ser Ser Pro Ser Arg Gly His Ser Lys Pro 
    290                 295                 300                 


Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His Gln 
305                 310                 315                 320 


His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala Ala 
                325                 330                 335     


Lys Arg Ala Lys Leu Asp Ser Gly Arg Val Leu Lys Gln Ile Ser Asn 
            340                 345                 350         


Asn Arg Lys Cys Ser Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn Asp 
        355                 360                 365             


Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu 
    370                 375                 380                 


Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu Asn 
385                 390                 395                 400 


Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala Tyr 
                405                 410                 415     


Ile Leu Ser Ile Gln Ala Asp Glu His Lys Leu Thr Ser Glu Lys Asp 
            420                 425                 430         


Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln Leu 
        435                 440                 445             


Arg Asn Ser Gly Ala 
    450             


<210>  31
<211>  2355
<212>  DNA
<213>  Rattus norvegicus

<400>  31
acccccgggc tgcgctgctc tccgctgccg cctccgccgc gcccactccg ctcgcctcct       60

gcctccaaaa gggcagggct tcgccgaggc ttggcgggaa aaagaagcga ggggagggat      120

ccggagtcgc agtataaaag aagcttttcg ggcgtttttt ttctgactcg ctgtagtaat      180

tccagcgaga gacagaggga gtgagcgggc gggttggaag agcccagtgt gcagagcccc      240

actccgggct tcctaggaag gcagctctgg agtgagaagg gctttgcctc caggcttgct      300

gcctcctcga cccaatcctc ccgctgaccc aacatcagcg gtcgcaaccc tcgccgcctc      360

tgggaaactt tgcccattgc aacgggcaga cacttctcac tggaacttac aatctgcgag      420

ccaggacagg actccccagg cgcaggggag ggaatttttg tctatttggg gacagtgttc      480

tctgcctctg cccgcgatcg gctcccctga aaagagctcc tcgcgttatt tgaagcctga      540

atttcctttg ggaggtggaa aacccgacag tcacgacgat gcccctcaac gtgagcttcg      600

ctaacaggaa ctatgacctc gactacgact cggtgcagcc ctatttcatc tgcgacgagg      660

aagagaattt ctatcaccag caacagcaga gcgagctgca gccgcccgca cccagtgagg      720

atatctggaa gaaattcgag ctgctgccca ccccgcccct gtcccccagc cgccgctccg      780

ggctctgctc tccgtcctat gttgcggtcg ctacgtcctt ctccccaagg gaggacgatg      840

acggtggcgg tggcaacttc tccaccgccg atcagctgga gatgatgacc gagctacttg      900

gaggagacat ggtgaatcag agcttcatct gcgatcctga cgatgagacc ttcatcaaga      960

acatcatcat ccaggactgt atgtggagcg gcttctcggc cgctgccaaa ctggtctccg     1020

agaagctggc ctcttaccag gctgcgcgca aagacagcac cagcctgagc cccgcccgcg     1080

ggcacagcgt ctgctccacc tccagcctgt acctgcagga cctcaccgcc gcagcgtccg     1140

agtgcatcga cccctcagtg gtcttcccct acccgctcaa cgacagcagc tcgcccaaat     1200

cctgtacctc gtccgattcc acggccttct cttcttcctc ggactcgctg ctgtcctccg     1260

agtcctcccc acgggccacc cctgagcccc tagtgctgca tgaagagaca ccgcccacca     1320

ccagcagcga ctctgaagaa gaacaagatg atgaggaaga aattgatgtg gtgtctgtgg     1380

aaaagaggca accccctgcc aagaggtccg agtcagggtc atccccatca agaggccaca     1440

gcaaacctcc acacagccca ctggtcctca agaggtgcca tgtctctact caccagcaca     1500

attatgcagc acccccctcc acaaggaagg actatccagc tgccaagagg gccaagttgg     1560

acagtggcag ggtcctgaaa cagatcagca acaaccgcaa atgctccagc cccaggtcct     1620

cagacaccga ggaaaacgac aagaggcgga cacacaacgt cttggaacgt cagaggagaa     1680

acgagctgaa gcgtagcttt tttgccctgc gcgaccagat ccctgagttg gaaaacaacg     1740

aaaaggcccc caaggtagtt atcctcaaaa aagccaccgc ctacatcctg tccgttcaag     1800

cagatgagca caaactcatc tcagaaaagg acttactgag gaaacggcga gaacagttga     1860

aacacaaact cgaacagctt cgaaactctg gtgcataaac tgaccggaag tgaggaggag     1920

ctggaatctc gagtgtaagg agaacggttc cttctgacag aacttggact tcaaaaaatg     1980

catgctcaaa gcctaacctc acaaccttgg ctggggcttt gggacttcag ccataatgtt     2040

aactgcctca aagttaaggc ataaaagaac ttttttttat gcttcccatc ttctttcttt     2100

ttcctttaac agatttgtat ttaattgttt tttttaaaaa aatcttccgg tgtacatagg     2160

gcctttaaat gtaaataact ttaataaaac gtttataaca gttatacaag attttaagac     2220

atgtatgata aaccataatt ttttttattt aaagaccttt tcatttttaa agttgatttt     2280

tttctattgt ttttagaaaa aataaaataa ttggaaaaaa tataattgag ccaactctta     2340

aaaaaaaaaa aaaaa                                                      2355


<210>  32
<211>  453
<212>  PRT
<213>  Rattus norvegicus

<400>  32

Met Asn Phe Leu Trp Glu Val Glu Asn Pro Thr Val Thr Thr Met Pro 
1               5                   10                  15      


Leu Asn Val Ser Phe Ala Asn Arg Asn Tyr Asp Leu Asp Tyr Asp Ser 
            20                  25                  30          


Val Gln Pro Tyr Phe Ile Cys Asp Glu Glu Glu Asn Phe Tyr His Gln 
        35                  40                  45              


Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile Trp 
    50                  55                  60                  


Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg Arg 
65                  70                  75                  80  


Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Ala Thr Ser Phe Ser 
                85                  90                  95      


Pro Arg Glu Asp Asp Asp Gly Gly Gly Gly Asn Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Met Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Thr Ser 
                165                 170                 175     


Leu Ser Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Thr Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Thr 
    210                 215                 220                 


Ser Ser Asp Ser Thr Ala Phe Ser Ser Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Glu Ser Ser Pro Arg Ala Thr Pro Glu Pro Leu Val Leu His Glu 
                245                 250                 255     


Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Asp Asp 
            260                 265                 270         


Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Pro Pro Ala 
        275                 280                 285             


Lys Arg Ser Glu Ser Gly Ser Ser Pro Ser Arg Gly His Ser Lys Pro 
    290                 295                 300                 


Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His Gln 
305                 310                 315                 320 


His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala Ala 
                325                 330                 335     


Lys Arg Ala Lys Leu Asp Ser Gly Arg Val Leu Lys Gln Ile Ser Asn 
            340                 345                 350         


Asn Arg Lys Cys Ser Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn Asp 
        355                 360                 365             


Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu 
    370                 375                 380                 


Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu Asn 
385                 390                 395                 400 


Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala Tyr 
                405                 410                 415     


Ile Leu Ser Val Gln Ala Asp Glu His Lys Leu Ile Ser Glu Lys Asp 
            420                 425                 430         


Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln Leu 
        435                 440                 445             


Arg Asn Ser Gly Ala 
    450             


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  33
taccaccatg tacccaggca                                                   20


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  34
ctcaggagga gcaatgatct tgat                                              24


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  35
acaccgacca ccgtatctca                                                   20


<210>  36
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  36
ctcaggataa tggtagccat gtc                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  37
gacagagagt caaactaacg tgg                                               23


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  38
gtccagcagg caagaaggt                                                    19


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  39
aagaacacgc ttgggaatgg                                                   20


<210>  40
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  40
ctgcacctgc tgcggac                                                      17


<210>  41
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  41
gtgatagtgc agccggcat                                                    19


<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  42
aacggagcgt agcctttgg                                                    19


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  43
caagatcaag ccccacctga t                                                 21


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  44
agttcgcccc aaccagtact t                                                 21


<210>  45
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  45
tcatcggacg cacttggaa                                                    19


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  46
caaccacctt gaatggcaag a                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  47
gtccctagct tggctgacag a                                                 21


<210>  48
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  48
tggagagcga gggctttg                                                     18


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  49
tccactctcc ccatggttta                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  50
gctatatccg ctgcactacg                                                   20


<210>  51
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  51
ctggcggtag aatgcctct                                                    19


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  52
tgagaccatt gtgtggaagg                                                   20


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  53
gtggactaca gcgtttgcac a                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  54
catatcagcc ctcactgctg c                                                 21


<210>  55
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  55
ccccagtgtc aaactgtacc ag                                                22


<210>  56
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  56
agcgtttcca attttccata aatt                                              24


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  57
atccaaggca tcaaccagag                                                   20


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  58
atgbacaact acatggcgca c                                                 21


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  59
ctgtgtgctg tcagcttcca c                                                 21


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  60
cctcctcccc agtgtgactc                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  61
agtgacgcaa ggaccaaacg                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  62
ctacacgaaa cgcttcccca                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  63
ccaacaaatg caatgggagt                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  64
caagagtccc agggagagtg                                                   20


<210>  65
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  65
tgagggttca tcaagctggt gtct                                              24


<210>  66
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  66
ttggagaggg cagtgcttaa ctca                                              24


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  67
ctcgtctgtc gactcacttc                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  68
tggaaaactg ttgttgctgc                                                   20