                         SEQUENCE LISTING

<110>  Celldex Therapeutics, Inc.
 
<120>  ANTI-MERTK ANTIBODIES AND METHODS OF USE THEREOF

<130>  12638-160-228

<140>
<141>

<150>  US 62/826,301
<151>  2019-03-29

<150>  US 62/757,651
<151>  2018-11-08

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3000 VH

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Tyr Ser Gly Thr Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  2
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3000 VL

<400>  2

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Arg Leu Phe Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 of Anti-MerTK Antibody - Kabat

<400>  3

Ser Tyr Gly Met His 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 of Anti-MerTK Antibody - Kabat

<400>  4

Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr Ser Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 of Anti-MerTK Antibody - Kabat

<400>  5

Val Gly Tyr Ser Gly Thr Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 of Anti-MerTK Antibody - Kabat

<400>  6

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 of Anti-MerTK Antibody - Kabat

<400>  7

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 of Anti-MerTK Antibody - Kabat

<400>  8

Gln Gln Leu Asn Arg Leu Phe Thr 
1               5               


<210>  9
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain 1 (Ig-like domain 1) of hMerTK ECDs

<400>  9

Glu Ala Arg Glu Glu Ala Lys Pro Tyr Pro Leu Phe Pro Gly Pro Phe 
1               5                   10                  15      


Pro Gly Ser Leu Gln Thr Asp His Thr Pro Leu Leu Ser Leu Pro His 
            20                  25                  30          


Ala Ser Gly Tyr Gln Pro Ala Leu Met Phe Ser Pro Thr Gln Pro Gly 
        35                  40                  45              


Arg Pro His Thr Gly Asn Val Ala Ile Pro Gln Val Thr Ser Val Glu 
    50                  55                  60                  


Ser Lys Pro Leu Pro Pro Leu Ala Phe Lys His Thr Val Gly His Ile 
65                  70                  75                  80  


Ile Leu Ser Glu His Lys Gly Val Lys Phe Asn Cys Ser Ile Ser Val 
                85                  90                  95      


Pro Asn Ile Tyr Gln Asp Thr Thr Ile Ser Trp Trp Lys Asp Gly Lys 
            100                 105                 110         


Glu Leu Leu Gly Ala His His Ala Ile Thr Gln Phe Tyr Pro Asp Asp 
        115                 120                 125             


Glu Val Thr Ala Ile Ile Ala Ser Phe Ser Ile Thr Ser Val Gln Arg 
    130                 135                 140                 


Ser Asp Asn Gly Ser Tyr Ile Cys Lys Met Lys Ile Asn Asn Glu Glu 
145                 150                 155                 160 


Ile Val Ser Asp Pro Ile Tyr Ile Glu Val Gln Gly 
                165                 170         


<210>  10
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain 2 (Ig-like domain 2) of hMerTK ECDs

<400>  10

Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val Thr Arg Asn 
1               5                   10                  15      


Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro Glu Pro Val 
            20                  25                  30          


Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu Gln Pro Glu 
        35                  40                  45              


Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu Met Ala Val 
    50                  55                  60                  


Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val Ser Lys Gly 
65                  70                  75                  80  


Val Gln Ile Asn Ile Lys 
                85      


<210>  11
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain 3 (FnIII-like domain 1) of hMerTK ECDs

<400>  11

Ala Ile Pro Ser Pro Pro Thr Glu Val Ser Ile Arg Asn Ser Thr Ala 
1               5                   10                  15      


His Ser Ile Leu Ile Ser Trp Val Pro Gly Phe Asp Gly Tyr Ser Pro 
            20                  25                  30          


Phe Arg Asn Cys Ser Ile Gln Val Lys Glu Ala Asp Pro Leu Ser Asn 
        35                  40                  45              


Gly Ser Val Met Ile Phe Asn Thr Ser Ala Leu Pro His Leu Tyr Gln 
    50                  55                  60                  


Ile Lys Gln Leu Gln Ala Leu Ala Asn Tyr Ser Ile Gly Val Ser Cys 
65                  70                  75                  80  


Met Asn Glu Ile Gly Trp Ser Ala Val Ser Pro Trp Ile Leu Ala Ser 
                85                  90                  95      


Thr Thr Glu Gly 
            100 


<210>  12
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Domain 4 (FnIII-like domain 2) of hMerTK ECDs

<400>  12

Ala Pro Ser Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser 
1               5                   10                  15      


Ser Asp Asn Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln 
            20                  25                  30          


Asp Gly Glu Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala 
        35                  40                  45              


Gly Ile Ser Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg 
    50                  55                  60                  


Ala Arg Ile Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile 
65                  70                  75                  80  


Ala Ala Val Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys 
                85                  90                  95      


Ile Phe Ile Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr 
            100                 105                 110         


Pro Ala Pro Gly Asn 
        115         


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 of Anti-MerTK Antibody - Chothia

<400>  13

Gly Phe Thr Phe Arg Ser Tyr 
1               5           


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 of Anti-MerTK Antibody - Chothia

<400>  14

Trp Asn Asp Gly Ser Asn 
1               5       


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 of Anti-MerTK Antibody - Chothia

<400>  15

Val Gly Tyr Ser Gly Thr Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 of Anti-MerTK Antibody - Chothia

<400>  16

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 of Anti-MerTK Antibody - Chothia

<400>  17

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 of Anti-MerTK Antibody - Chothia

<400>  18

Gln Gln Leu Asn Arg Leu Phe Thr 
1               5               


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 of Anti-MerTK Antibody - AbM

<400>  19

Gly Phe Thr Phe Arg Ser Tyr Gly Met His 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 of Anti-MerTK Antibody - AbM

<400>  20

Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr 
1               5                   10  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 of Anti-MerTK Antibody - AbM

<400>  21

Val Gly Tyr Ser Gly Thr Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 of Anti-MerTK Antibody - AbM

<400>  22

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 of Anti-MerTK Antibody - AbM

<400>  23

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 of Anti-MerTK Antibody - AbM

<400>  24

Gln Gln Leu Asn Arg Leu Phe Thr 
1               5               


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 of Anti-MerTK Antibody - Contact

<400>  25

Arg Ser Tyr Gly Met His 
1               5       


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 of Anti-MerTK Antibody - Contact

<400>  26

Trp Val Ala Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr 
1               5                   10              


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 of Anti-MerTK Antibody - Contact

<400>  27

Ala Arg Val Gly Tyr Ser Gly Thr Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 of Anti-MerTK Antibody - Contact

<400>  28

Ser Asn Tyr Leu Ala Trp Tyr 
1               5           


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 of Anti-MerTK Antibody - Contact

<400>  29

Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln 
1               5                   10  


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 of Anti-MerTK Antibody - Contact

<400>  30

Gln Gln Leu Asn Arg Leu Phe 
1               5           


<210>  31
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Light Chain constant region

<400>  31

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  32
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Heavy Chain constant region

<400>  32

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  33
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG2 Heavy Chain Constant Region

<400>  33

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly 
                325 


<210>  34
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3000 Heavy Chain IgG1

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Tyr Ser Gly Thr Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly 
    450             


<210>  35
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3000 Heavy Chain IgG2

<400>  35

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Tyr Ser Gly Thr Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
    210                 215                 220                 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  36
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3000 Light Chain

<400>  36

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Arg Leu Phe Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  37
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3000 Heavy Chain IgG1 (with signal sequence)

<400>  37

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Arg Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr Ser Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Val Gly Tyr Ser Gly Thr Tyr Tyr Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  38
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3000 Heavy Chain IgG2 (with signal sequence)

<400>  38

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Arg Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr Ser Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Val Gly Tyr Ser Gly Thr Tyr Tyr Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
225                 230                 235                 240 


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly 
465             


<210>  39
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3000 Light Chain (with signal sequence)

<400>  39

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn 
            100                 105                 110         


Arg Leu Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  40
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3000 VH (with signal sequence)

<400>  40
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcagctgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgcagcgt ctggattcac cttcaggagt tatggcatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tggaatgatg gaagtaataa atactctgca      240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtact actgtgcgag agtggggtat      360

agtgggacct actactacta ctacggtatg gacgtctggg gccaagggac cacggtcacc      420

gtctcctca                                                              429


<210>  41
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3000 VL (with signal sequence)

<400>  41
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggctcccagg tgccagatgt       60

gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggccagtca gggcattagt aattatttag cctggtatca gcaaaaacca      180

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      240

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacaa cttaatcgtt tattcacttt cggccctggg      360

accaaagtgg atatcaaa                                                    378


<210>  42
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3000 VH

<400>  42
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagg agttatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggaatg atggaagtaa taaatactct      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt actactgtgc gagagtgggg      300

tatagtggga cctactacta ctactacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210>  43
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3000 VL

<400>  43
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagt aattatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacaa cttaatcgtt tattcacttt cggccctggg      300

accaaagtgg atatcaaa                                                    318


<210>  44
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain signal sequence

<400>  44
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgt          57


<210>  45
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain signal sequence

<400>  45
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggctcccagg tgccagatgt       60


<210>  46
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain signal sequence

<400>  46

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  47
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain signal sequence

<400>  47

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys 
            20  


<210>  48
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3000 VH (with signal sequence)

<400>  48

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Arg Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr Ser Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Val Gly Tyr Ser Gly Thr Tyr Tyr Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140             


<210>  49
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3000 VL (with signal sequence)

<400>  49

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn 
            100                 105                 110         


Arg Leu Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
        115                 120                 125     


