                         SEQUENCE LISTING

<110>  University of Kentucky Research Foundation
       Rohr, Jurgen
 
<120>  MITHRAMYCIN DERIVATIVES HAVING INCREASED SELECTIVITY AND 
       ANTI-CANCER ACTIVITY

<130>  13177N/2198SK-WO

<150>  62/734,464
<151>  2018-09-21

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  1

Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu 
1               5                   10                  15      


Ser Asp Ser Ala Asn Ala Ser Cys Ile Thr Trp Glu Gly Thr Asn Gly 
            20                  25                  30          


Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly Glu 
        35                  40                  45              


Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu 
    50                  55                  60                  


Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys Arg 
65                  70                  75                  80  


Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln Pro 
                85                  90                  95      


His Pro 
        


<210>  2
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  2

Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu 
1               5                   10                  15      


Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr Trp Glu Gly Thr Asn Gly 
            20                  25                  30          


Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly Glu 
        35                  40                  45              


Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu 
    50                  55                  60                  


Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys Arg 
65                  70                  75                  80  


Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln Pro 
                85                  90                  95      


His Pro 
        


<210>  3
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  3

Met Asp Gly Thr Ile Lys Glu Ala Leu Ser Val Val Ser Asp Asp Gln 
1               5                   10                  15      


Ser Leu Phe Asp Ser Ala Tyr Gly Ala Ala Ala His Leu Pro Lys Ala 
            20                  25                  30          


Asp Met Thr Ala Ser Gly Ser Pro Asp Tyr Gly Gln Pro His Lys Ile 
        35                  40                  45              


Asn Pro Leu Pro Pro Gln Gln Glu Trp Ile Asn Gln Pro Val Arg Val 
    50                  55                  60                  


Asn Val Lys Arg Glu Tyr Asp His Met Asn Gly Ser Arg Glu Ser Pro 
65                  70                  75                  80  


Val Asp Cys Ser Val Ser Lys Cys Ser Lys Leu Val Gly Gly Gly Glu 
                85                  90                  95      


Ser Asn Pro Met Asn Tyr Asn Ser Tyr Met Asp Glu Lys Asn Gly Pro 
            100                 105                 110         


Pro Pro Pro Asn Met Thr Thr Asn Glu Arg Arg Val Ile Val Pro Ala 
        115                 120                 125             


Asp Pro Thr Leu Trp Thr Gln Glu His Val Arg Gln Trp Leu Glu Trp 
    130                 135                 140                 


Ala Ile Lys Glu Tyr Ser Leu Met Glu Ile Asp Thr Ser Phe Phe Gln 
145                 150                 155                 160 


Asn Met Asp Gly Lys Glu Leu Cys Lys Met Asn Lys Glu Asp Phe Leu 
                165                 170                 175     


Arg Ala Thr Thr Leu Tyr Asn Thr Glu Val Leu Leu Ser His Leu Ser 
            180                 185                 190         


Tyr Leu Arg Glu Ser Ser Leu Leu Ala Tyr Asn Thr Thr Ser His Thr 
        195                 200                 205             


Asp Gln Ser Ser Arg Leu Ser Val Lys Glu Asp Pro Ser Tyr Asp Ser 
    210                 215                 220                 


Val Arg Arg Gly Ala Trp Gly Asn Asn Met Asn Ser Gly Leu Asn Lys 
225                 230                 235                 240 


Ser Pro Pro Leu Gly Gly Ala Gln Thr Ile Ser Lys Asn Thr Glu Gln 
                245                 250                 255     


Arg Pro Gln Pro Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg 
            260                 265                 270         


Leu Ala Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu 
        275                 280                 285             


Glu Leu Leu Ser Asp Ser Ala Asn Ala Ser Cys Ile Thr Trp Glu Gly 
    290                 295                 300                 


Thr Asn Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg 
305                 310                 315                 320 


Trp Gly Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser 
                325                 330                 335     


Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His 
            340                 345                 350         


Gly Lys Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala 
        355                 360                 365             


Leu Gln Pro His Pro Thr Glu Ser Ser Met Tyr Lys Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ser Tyr Met Pro Ser Tyr His Ala His Gln Gln Lys Val Asn Phe 
385                 390                 395                 400 


Val Pro Pro His Pro Ser Ser Met Pro Val Thr Ser Ser Ser Phe Phe 
                405                 410                 415     


Gly Ala Ala Ser Gln Tyr Trp Thr Ser Pro Thr Gly Gly Ile Tyr Pro 
            420                 425                 430         


Asn Pro Asn Val Pro Arg His Pro Asn Thr His Val Pro Ser His Leu 
        435                 440                 445             


Gly Ser Tyr Tyr 
    450         


<210>  4
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  4

Met Ile Gln Thr Val Pro Asp Pro Ala Ala His Ile Lys Glu Ala Leu 
1               5                   10                  15      


Ser Val Val Ser Asp Glu Gln Ser Leu Phe Glu Cys Ala Tyr Gly Thr 
            20                  25                  30          


Pro His Leu Ala Lys Thr Glu Met Thr Ala Ser Ser Ser Ser Asp Tyr 
        35                  40                  45              


Gly Gln Thr Ser Lys Met Ser Pro Arg Val Pro Gln Gln Asp Trp Leu 
    50                  55                  60                  


Ser Gln Pro Pro Ala Arg Val Thr Ile Lys Met Glu Cys Asn Pro Ser 
65                  70                  75                  80  


Gln Val Asn Gly Ser Arg Asn Ser Pro Asp Glu Cys Ser Val Ala Lys 
                85                  90                  95      


Gly Gly Lys Met Val Gly Ser Pro Asp Thr Val Gly Met Asn Tyr Gly 
            100                 105                 110         


Ser Tyr Met Glu Glu Lys His Met Pro Pro Pro Asn Met Thr Thr Asn 
        115                 120                 125             


Glu Arg Arg Val Ile Val Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp 
    130                 135                 140                 


His Val Arg Gln Trp Leu Glu Trp Ala Val Lys Glu Tyr Gly Leu Pro 
145                 150                 155                 160 


Asp Val Asn Ile Leu Leu Phe Gln Asn Ile Asp Gly Lys Glu Leu Cys 
                165                 170                 175     


Lys Met Thr Lys Asp Asp Phe Gln Arg Leu Thr Pro Ser Tyr Asn Ala 
            180                 185                 190         


Asp Ile Leu Leu Ser His Leu His Tyr Leu Arg Glu Thr Pro Leu Pro 
        195                 200                 205             


His Leu Thr Ser Asp Asp Val Asp Lys Ala Leu Gln Asn Ser Pro Arg 
    210                 215                 220                 


Leu Met His Ala Arg Asn Thr Asp Leu Pro Tyr Glu Pro Pro Arg Arg 
225                 230                 235                 240 


Ser Ala Trp Thr Gly His Gly His Pro Thr Pro Gln Ser Lys Ala Ala 
                245                 250                 255     


Gln Pro Ser Pro Ser Thr Val Pro Lys Thr Glu Asp Gln Arg Pro Gln 
            260                 265                 270         


Leu Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala Asn 
        275                 280                 285             


Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu 
    290                 295                 300                 


Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr Trp Glu Gly Thr Asn Gly 
305                 310                 315                 320 


Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly Glu 
                325                 330                 335     


Arg Lys Ser Lys Pro Asn Met Tyr Asp Lys Leu Ser Arg Ala Leu Arg 
            340                 345                 350         


Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys Arg Tyr 
        355                 360                 365             


Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gly Pro His 
    370                 375                 380                 


Gln Gln Glu Ser Ser Leu Tyr Lys Tyr Pro Ser Asp Leu Pro Tyr Met 
385                 390                 395                 400 


Gly Ser Tyr His Ala His Pro Gln Lys Met Asn Phe Val Ala Pro His 
                405                 410                 415     


Pro Pro Ala Leu Pro Val Thr Ser Ser Ser Phe Phe Ala Ala Pro Asn 
            420                 425                 430         


Pro Tyr Trp Asn Ser Pro Thr Gly Gly Tyr Pro Asn Thr Arg Leu Pro 
        435                 440                 445             


Thr Ser His Met Pro Ser His Leu Gly Thr Tyr Tyr 
    450                 455                 460 


