                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS FOR PREDICTING METASTATIC POTENTIAL IN PATIENTS SUFFERING
        FROM SDHB-MUTATED PARAGANGLIOMA

<130>  BIO18424 FAVIER / MC

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Val Val Ala Leu Ser Leu Arg Arg Arg Leu Pro Ala Thr 
1               5                   10                  15      


Thr Leu Gly Gly Ala Cys Leu Gln Ala Ser Arg Gly Ala Gln Thr Ala 
            20                  25                  30          


Ala Ala Thr Ala Pro Arg Ile Lys Lys Phe Ala Ile Tyr Arg Trp Asp 
        35                  40                  45              


Pro Asp Lys Ala Gly Asp Lys Pro His Met Gln Thr Tyr Glu Val Asp 
    50                  55                  60                  


Leu Asn Lys Cys Gly Pro Met Val Leu Asp Ala Leu Ile Lys Ile Lys 
65                  70                  75                  80  


Asn Glu Val Asp Ser Thr Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly 
                85                  90                  95      


Ile Cys Gly Ser Cys Ala Met Asn Ile Asn Gly Gly Asn Thr Leu Ala 
            100                 105                 110         


Cys Thr Arg Arg Ile Asp Thr Asn Leu Asn Lys Val Ser Lys Ile Tyr 
        115                 120                 125             


Pro Leu Pro His Met Tyr Val Ile Lys Asp Leu Val Pro Asp Leu Ser 
    130                 135                 140                 


Asn Phe Tyr Ala Gln Tyr Lys Ser Ile Glu Pro Tyr Leu Lys Lys Lys 
145                 150                 155                 160 


Asp Glu Ser Gln Glu Gly Lys Gln Gln Tyr Leu Gln Ser Ile Glu Glu 
                165                 170                 175     


Arg Glu Lys Leu Asp Gly Leu Tyr Glu Cys Ile Leu Cys Ala Cys Cys 
            180                 185                 190         


Ser Thr Ser Cys Pro Ser Tyr Trp Trp Asn Gly Asp Lys Tyr Leu Gly 
        195                 200                 205             


Pro Ala Val Leu Met Gln Ala Tyr Arg Trp Met Ile Asp Ser Arg Asp 
    210                 215                 220                 


Asp Phe Thr Glu Glu Arg Leu Ala Lys Leu Gln Asp Pro Phe Ser Leu 
225                 230                 235                 240 


Tyr Arg Cys His Thr Ile Met Asn Cys Thr Arg Thr Cys Pro Lys Gly 
                245                 250                 255     


Leu Asn Pro Gly Lys Ala Ile Ala Glu Ile Lys Lys Met Met Ala Thr 
            260                 265                 270         


Tyr Lys Glu Lys Lys Ala Ser Val 
        275                 280 


<210>  2
<211>  2333
<212>  DNA
<213>  Homo sapiens

<400>  2
tttgattcct atctcgttca aatttttggt tcatcgtcac ctcaacctgg atttgggatg       60

tcaggggaag aactcagtga atctactcca gagcctcaaa aagaaatttc tgagtcattg      120

agtgtcacca gagaccagga tgaagatgat aaggctccag agccaacgtg ggctgatgat      180

ctgcctgcca ctacctcatc tgaggccacc accaccccca ggccactgct cagcacccct      240

gtggatgggg cagaggatcc tagatgtttg gaagccttga agcctggaaa ctgtggtgaa      300

tatgtggttc gatggtatta tgacaaacag gtcaactctt gtgcccgatt ttggttcagt      360

ggctgtaatg gctcaggaaa tagattcaac agtgaaaagg aatgtcaaga aacctgcatt      420

caaggatgag caagtaaatt ggcctgtctc tatcaaaagc atagaactcc ctaatttcca      480

catattcacc caatacaaat acagcactat atttgagtgt atactgagta tttacaactt      540

atacatgtaa ttgaattctc actacagccc taggatgtac atattattaa ccacttatat      600

aggtaagaaa gctgaggctc tgagaagttt agtaacttgt caactgtcac ccaactaaaa      660

agtttcagag ctgaggattt agacttagag ctgtgtaact tcaatacaca gactctatct      720

acttcacaac ctgcaatgtg attctgattc ctttaattcc tgttgtatgt actatgtcag      780

ctcaaacccc tacccctgtc cctgcccata cctccaccca ctcacctccc taacctcctt      840

atgtccctca cagtagcaag atgtaggtga taggaaggac ttcggtgtga gaattagaaa      900

tgatgtaaat gtttacgcag gagtgctggg ataggagtcg ggatggtgag ggtagttaga      960

tttttgcctc acttgccctg aaagtggtaa tagggagaaa ccaatctgaa ttacaattac     1020

ttaaatgtat cacagactgt cactttgtat tcctccaaca tgtttggtaa caagtgttta     1080

atgtatgtta aaacaaagaa ggtttttata cccttccatt aaaatatgtc agtgggccct     1140

tccattttat ggagtggaat gggaaggccc ttgacagcca ggaaccactt gaagttggca     1200

tccactcttg aacagtgtgt attaaagaca ggattcacac tgaaaagtga gccaccaaat     1260

tgaaatgcga gtaatggaga gtaacggaga attgactctg tcattttata atacttttgc     1320

aagatcctgt ctgggaagag cattagttct gagctgagtt cagacagcac ttgcatattt     1380

ctttcttttt tttttttttc ccccagacag agtcttgctc tgcactccag cctgggtgac     1440

acagcaagac tctgtctcaa aacaaaaaca aaaacaaaaa acaaaatact ttctccttct     1500

atcaggtcta ccctcattca attcaacagt gcaaaaaaga gcactcacgg aagaaggaga     1560

tggaagaata gccatcttgg cagaaataat gatatgtata atttttttat ttaattaaaa     1620

ttgtattatg taatatttga tactacaaaa gataatgcaa catgtttgtc aatttttttt     1680

attatacttt aagttttagg gtacatgtgc acaaagtaca gatttgttac atatgtattc     1740

atgtgccatg ttggtgtgct gcacccatta actcgtcatt taacattagg tatatttcct     1800

aatgctatcc ctccccactc ccccgccacc ccacaacagg ccctggtgtg tgatgttccc     1860

cttcctgtgt ccatgtgttc tcattgttca actcccacct atgagtgaga acatgcggtg     1920

tttggttttt tgtccttgtg acagtttgct gagaatgatg gtttccagct tcatccatgc     1980

ccctacaaag gacatgaact catcattttt tatggctgca tagtattctg tggtgtatat     2040

gtaacatgct tgtcaattta aaaacatgat aagatgaaca ccagtgaaca catcacctag     2100

agaatgaagc aaacatcaaa aattctattg cagcttcccg tgtggccctc cgccatccca     2160

gctctctatt ccatgccagg gatatcccat tttgaacttc gtatttacca tgtcaatgtg     2220

ctgttgacat ttataggtaa ttttacatgt aaaactctat atatctctat gtgttgccaa     2280

acaataaata tttagccttg cttattttac agttttaaaa aaaaaaaaaa aaa            2333


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  3
agccaccaaa ttgaaatgcg a                                                 21


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  4
tgcaagtgct gtctgaactc                                                   20


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  5
catgttcgtc atgggtgtga acca                                              24


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  6
atggcatgga ctgtggtcat gagt                                              24


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  7
tgctgcttgc tgtgagtgtc t                                                 21


<210>  8
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  8
cgcggaccag gaccttt                                                      17


