                         SEQUENCE LISTING

<110>  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
       ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
 
<120>  PCDH1-BINDING AGENTS AND USES THEREO

<130>  25301-P56851PC00

<150>  US 62/770,260
<151>  2018-11-21

<160>  265   

<170>  PatentIn version 3.5

<210>  1
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Arg Val Val Tyr Lys Val Pro Glu Glu Gln Pro Pro Asn Thr Leu 
1               5                   10                  15      


Ile Gly Ser Leu Ala Ala Asp Tyr Gly Phe Pro Asp Val Gly His Leu 
            20                  25                  30          


Tyr Lys Leu Glu Val Gly Ala Pro Tyr Leu Arg Val Asp Gly Lys Thr 
        35                  40                  45              


Gly Asp Ile Phe Thr Thr Glu Thr Ser Ile Asp Arg Glu Gly Leu Arg 
    50                  55                  60                  


Glu Cys Gln Asn Gln Leu Pro Gly Asp Pro Cys Ile Leu Glu Phe Glu 
65                  70                  75                  80  


Val Ser Ile Thr Asp Leu Val Gln Asn Gly Ser Pro Arg Leu Leu Glu 
                85                  90                  95      


Gly Gln Ile Glu Val Gln Asp Ile Asn Asp Asn Thr Pro Asn Phe Ala 
            100                 105                 110         


Ser Pro Val Ile Thr Leu Ala Ile Pro Glu Asn Thr Asn Ile Gly Ser 
        115                 120                 125             


Leu Phe Pro Ile Pro Leu Ala Ser Asp Arg Asp Ala Gly Pro Asn Gly 
    130                 135                 140                 


Val Ala Ser Tyr Glu Leu Gln Ala Gly Pro Glu Ala Gln Glu Leu Phe 
145                 150                 155                 160 


Gly Leu Gln Val Ala Glu Asp Gln Glu Glu Lys Gln Pro Gln Leu Ile 
                165                 170                 175     


Val Met Gly Asn Leu Asp Arg Glu Arg Trp Asp Ser Tyr Asp Leu Thr 
            180                 185                 190         


Ile Lys Val Gln Asp Gly Gly Ser Pro Pro Arg Ala Ser Ser Ala Leu 
        195                 200                 205             


Leu Arg Val Thr Val Leu Asp Thr Asn Asp Asn Ala Pro Lys Phe Glu 
    210                 215                 220                 


Arg Pro Ser Tyr Glu Ala Glu Leu Ser Glu Asn Ser Pro Ile Gly His 
225                 230                 235                 240 


Ser Val Ile Gln Val Lys Ala Asn Asp Ser Asp Gln Gly Ala Asn Ala 
                245                 250                 255     


Glu Ile Glu Tyr Thr Phe His Gln Ala Pro Glu Val Val Arg Arg Leu 
            260                 265                 270         


Leu Arg Leu Asp Arg Asn Thr Gly Leu Ile Thr Val Gln Gly Pro Val 
        275                 280                 285             


Asp Arg Glu Asp Leu Ser Thr Leu Arg Phe Ser Val Leu Ala Lys Asp 
    290                 295                 300                 


Arg Gly Thr Asn Pro Lys Ser Ala Arg Ala Gln Val Val Val Thr Val 
305                 310                 315                 320 


Lys Asp Met Asn Asp Asn Ala Pro Thr Ile Glu Ile Arg Gly Ile Gly 
                325                 330                 335     


Leu Val Thr His Gln Asp Gly Met Ala Asn Ile Ser Glu Asp Val Ala 
            340                 345                 350         


Glu Glu Thr Ala Val Ala Leu Val Gln Val Ser Asp Arg Asp Glu Gly 
        355                 360                 365             


Glu Asn Ala Ala Val Thr Cys Val Val Ala Gly Asp Val Pro Phe Gln 
    370                 375                 380                 


Leu Arg Gln Ala Ser Glu Thr Gly Ser Asp Ser Lys Lys Lys Tyr Phe 
385                 390                 395                 400 


Leu Gln Thr Thr Thr Pro Leu Asp Tyr Glu Lys Val Lys Asp Tyr Thr 
                405                 410                 415     


Ile Glu Ile Val Ala Val Asp Ser Gly Asn Pro Pro Leu Ser Ser Thr 
            420                 425                 430         


Asn Ser Leu Lys Val Gln Val Val Asp Val Asn Asp Asn Ala Pro Val 
        435                 440                 445             


Phe Thr Gln Ser Val Thr Glu Val Ala Phe Pro Glu Asn Asn Lys Pro 
    450                 455                 460                 


Gly Glu Val Ile Ala Glu Ile Thr Ala Ser Asp Ala Asp Ser Gly Ser 
465                 470                 475                 480 


Asn Ala Glu Leu Val Tyr Ser Leu Glu Pro Glu Pro Ala Ala Lys Gly 
                485                 490                 495     


Leu Phe Thr Ile Ser Pro Glu Thr Gly Glu Ile Gln Val Lys Thr Ser 
            500                 505                 510         


Leu Asp Arg Glu Gln Arg Glu Ser Tyr Glu Leu Lys Val Val Ala Ala 
        515                 520                 525             


Asp Arg Gly Ser Pro Ser Leu Gln Gly Thr Ala Thr Val Leu Val Asn 
    530                 535                 540                 


Val Leu Asp Cys Asn Asp Asn Asp Pro Lys Phe Met Leu Ser Gly Tyr 
545                 550                 555                 560 


Asn Phe Ser Val Met Glu Asn Met Pro Ala Leu Ser Pro Val Gly Met 
                565                 570                 575     


Val Thr Val Ile Asp Gly Asp Lys Gly Glu Asn Ala Gln Val Gln Leu 
            580                 585                 590         


Ser Val Glu Gln Asp Asn Gly Asp Phe Val Ile Gln Asn Gly Thr Gly 
        595                 600                 605             


Thr Ile Leu Ser Ser Leu Ser Phe Asp Arg Glu Gln Gln Ser Thr Tyr 
    610                 615                 620                 


Thr Phe Gln Leu Lys Ala Val Asp Gly Gly Val Pro Pro Arg Ser Ala 
625                 630                 635                 640 


Tyr Val Gly Val Thr Ile Asn Val Leu Asp Glu Asn Asp Asn Ala Pro 
                645                 650                 655     


Tyr Ile Thr Ala Pro Ser Asn Thr Ser His Lys Leu Leu Thr Pro Gln 
            660                 665                 670         


Thr Arg Leu Gly Glu Thr Val Ser Gln Val Ala Ala Glu Asp Phe Asp 
        675                 680                 685             


Ser Gly Val Asn Ala Glu Leu Ile Tyr Ser Ile Ala Gly Gly Asn Pro 
    690                 695                 700                 


Tyr Gly Leu Phe Gln Ile Gly Ser His Ser Gly Ala Ile Thr Leu Glu 
705                 710                 715                 720 


Lys Glu Ile Glu Arg Arg His His Gly Leu His Arg Leu Val Val Lys 
                725                 730                 735     


Val Ser Asp Arg Gly Lys Pro Pro Arg Tyr Gly Thr Ala Leu Val His 
            740                 745                 750         


Leu Tyr Val Asn Glu Thr Leu Ala Asn Arg Thr Leu Leu Glu Thr Leu 
        755                 760                 765             


Leu Gly His Ser Leu Asp Thr Pro Leu Asp Ile Asp Ile Ala Gly Asp 
    770                 775                 780                 


Pro Glu Tyr Glu Arg Ser Lys Gln Arg Gly 
785                 790                 


<210>  2
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Arg Val Val Tyr Lys Val Pro Glu Glu Gln Pro Pro Asn Thr Leu 
1               5                   10                  15      


Ile Gly Ser Leu Ala Ala Asp Tyr Gly Phe Pro Asp Val Gly His Leu 
            20                  25                  30          


Tyr Lys Leu Glu Val Gly Ala Pro Tyr Leu Arg Val Asp Gly Lys Thr 
        35                  40                  45              


Gly Asp Ile Phe Thr Thr Glu Thr Ser Ile Asp Arg Glu Gly Leu Arg 
    50                  55                  60                  


Glu Cys Gln Asn Gln Leu Pro Gly Asp Pro Cys Ile Leu Glu Phe Glu 
65                  70                  75                  80  


Val Ser Ile Thr Asp Leu Val Gln Asn Gly Ser Pro Arg Leu Leu Glu 
                85                  90                  95      


Gly Gln Ile Glu Val Gln Asp Ile Asn Asp Asn Thr Pro Asn Phe Ala 
            100                 105                 110         


Ser Pro Val Ile Thr Leu Ala Ile Pro Glu Asn Thr Asn Ile Gly Ser 
        115                 120                 125             


Leu Phe Pro Ile Pro Leu Ala Ser Asp Arg Asp Ala Gly Pro Asn Gly 
    130                 135                 140                 


Val Ala Ser Tyr Glu Leu Gln Ala Gly Pro Glu Ala Gln Glu Leu Phe 
145                 150                 155                 160 


Gly Leu Gln Val Ala Glu Asp Gln Glu Glu Lys Gln Pro Gln Leu Ile 
                165                 170                 175     


Val Met Gly Asn Leu Asp Arg Glu Arg Trp Asp Ser Tyr Asp Leu Thr 
            180                 185                 190         


Ile Lys Val Gln Asp Gly Gly Ser Pro Pro Arg Ala Ser Ser Ala Leu 
        195                 200                 205             


Leu Arg Val Thr Val Leu Asp Thr Asn Asp Asn Ala Pro Lys Phe Glu 
    210                 215                 220                 


Arg Pro Ser Tyr Glu Ala Glu Leu Ser Glu Asn Ser Pro Ile Gly His 
225                 230                 235                 240 


Ser Val Ile Gln Val Lys Ala Asn Asp Ser Asp Gln Gly Ala Asn Ala 
                245                 250                 255     


Glu Ile Glu Tyr Thr Phe His Gln Ala Pro Glu Val Val Arg Arg Leu 
            260                 265                 270         


Leu Arg Leu Asp Arg Asn Thr Gly Leu Ile Thr Val Gln Gly Pro Val 
        275                 280                 285             


Asp Arg Glu Asp Leu Ser Thr Leu Arg Phe Ser Val Leu Ala Lys Asp 
    290                 295                 300                 


Arg Gly Thr Asn Pro Lys Ser Ala Arg Ala Gln Val Val Val Thr Val 
305                 310                 315                 320 


Lys Asp Met Asn Asp Asn Ala Pro Thr Ile Glu Ile Arg Gly Ile Gly 
                325                 330                 335     


Leu Val Thr His Gln Asp Gly Met Ala Asn Ile Ser Glu Asp Val Ala 
            340                 345                 350         


Glu Glu Thr Ala Val Ala Leu Val Gln Val Ser Asp Arg Asp Glu Gly 
        355                 360                 365             


Glu Asn Ala Ala Val Thr Cys Val Val Ala Gly Asp Val Pro Phe Gln 
    370                 375                 380                 


Leu Arg Gln Ala Ser Glu Thr Gly Ser Asp Ser Lys Lys Lys Tyr Phe 
385                 390                 395                 400 


Leu Gln Thr Thr Thr Pro Leu Asp Tyr Glu Lys Val Lys Asp Tyr Thr 
                405                 410                 415     


Ile Glu Ile Val Ala Val Asp Ser Gly Asn Pro Pro Leu Ser Ser Thr 
            420                 425                 430         


Asn Ser Leu Lys Val Gln Val Val Asp Val Asn Asp Asn Ala Pro Val 
        435                 440                 445             


Phe Thr Gln Ser Val Thr Glu Val Ala Phe Pro Glu Asn Asn Lys Pro 
    450                 455                 460                 


Gly Glu Val Ile Ala Glu Ile Thr Ala Ser Asp Ala Asp Ser Gly Ser 
465                 470                 475                 480 


Asn Ala Glu Leu Val Tyr Ser Leu Glu Pro Glu Pro Ala Ala Lys Gly 
                485                 490                 495     


Leu Phe Thr Ile Ser Pro Glu Thr Gly Glu Ile Gln Val Lys Thr Ser 
            500                 505                 510         


Leu Asp Arg Glu Gln Arg Glu Ser Tyr Glu Leu Lys Val Val Ala Ala 
        515                 520                 525             


Asp Arg Gly Ser Pro Ser Leu Gln Gly Thr Ala Thr Val Leu Val Asn 
    530                 535                 540                 


Val Leu Asp Cys Asn Asp Asn Asp Pro Lys Phe Met Leu Ser Gly Tyr 
545                 550                 555                 560 


Asn Phe Ser Val Met Glu Asn Met Pro Ala Leu Ser Pro Val Gly Met 
                565                 570                 575     


Val Thr Val Ile Asp Gly Asp Lys Gly Glu Asn Ala Gln Val Gln Leu 
            580                 585                 590         


Ser Val Glu Gln Asp Asn Gly Asp Phe Val Ile Gln Asn Gly Thr Gly 
        595                 600                 605             


Thr Ile Leu Ser Ser Leu Ser Phe Asp Arg Glu Gln Gln Ser Thr Tyr 
    610                 615                 620                 


Thr Phe Gln Leu Lys Ala Val Asp Gly Gly Val Pro Pro Arg Ser Ala 
625                 630                 635                 640 


Tyr Val Gly Val Thr Ile Asn Val Leu Asp Glu Asn Asp Asn Ala Pro 
                645                 650                 655     


Tyr Ile Thr Ala Pro Ser Asn Thr Ser His Lys Leu Leu Thr Pro Gln 
            660                 665                 670         


Thr Arg Leu Gly Glu Thr Val Ser Gln Val Ala Ala Glu Asp Phe Asp 
        675                 680                 685             


Ser Gly Val Asn Ala Glu Leu Ile Tyr Ser Ile Ala Gly Gly Asn Pro 
    690                 695                 700                 


Tyr Gly Leu Phe Gln Ile Gly Ser His Ser Gly Ala Ile Thr Leu Glu 
705                 710                 715                 720 


Lys Glu Ile Glu Arg Arg His His Gly Leu His Arg Leu Val Val Lys 
                725                 730                 735     


Val Ser Asp Arg Gly Lys Pro Pro Arg Tyr Gly Thr Ala Leu Val His 
            740                 745                 750         


Leu Tyr Val Asn Glu Thr Leu Ala Asn Arg Thr Leu Leu Glu Thr Leu 
        755                 760                 765             


Leu Gly His Ser Leu Asp Thr Pro Leu Asp Ile Asp Ile Ala Gly Asp 
    770                 775                 780                 


Pro Glu Tyr Glu Arg Ser Lys Gln Arg Gly 
785                 790                 


<210>  3
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Leu Ala Ser Asp Arg Asp Ala Gly Pro Asn Gly Val Ala Ser Tyr 
1               5                   10                  15      


Glu Leu Gln Ala Gly Pro Glu Ala Gln Glu Leu Phe Gly Leu Gln Val 
            20                  25                  30          


Ala Glu Asp Gln Glu Glu Lys Gln Pro Gln Leu Ile Val Met Gly Asn 
        35                  40                  45              


Leu Asp Arg Glu Arg Trp Asp Ser Tyr Asp Leu Thr Ile Lys Val Gln 
    50                  55                  60                  


Asp Gly Gly Ser Pro Pro Arg Ala Ser Ser Ala Leu Leu Arg Val Thr 
65                  70                  75                  80  


Val Leu Asp Thr Asn Asp Asn Ala Pro Lys Phe Glu Arg Pro Ser Tyr 
                85                  90                  95      


Glu Ala Glu Leu Ser Glu Asn Ser Pro Ile Gly His Ser Val Ile Gln 
            100                 105                 110         


Val Lys Ala Asn Asp Ser Asp Gln Gly Ala Asn Ala Glu Ile Glu Tyr 
        115                 120                 125             


Thr Phe His Gln Ala Pro Glu Val Val Arg Arg Leu Leu Arg Leu Asp 
    130                 135                 140                 


Arg Asn Thr Gly Leu Ile Thr Val Gln Gly Pro Val Asp Arg Glu Asp 
145                 150                 155                 160 


Leu Ser Thr Leu Arg Phe Ser Val Leu Ala Lys Asp Arg Gly Thr Asn 
                165                 170                 175     


Pro Lys Ser Ala Arg Ala Gln Val Val Val Thr Val Lys Asp Met Asn 
            180                 185                 190         


Asp Asn Ala Pro Thr Ile Glu Ile Arg Gly Ile Gly Leu Val Thr His 
        195                 200                 205             


Gln Asp Gly Met Ala Asn Ile Ser Glu Asp Val Ala Glu Glu Thr Ala 
    210                 215                 220                 


Val Ala Leu Val Gln Val Ser Asp Arg Asp Glu Gly Glu Asn Ala Ala 
225                 230                 235                 240 


Val Thr Cys Val Val Ala Gly Asp Val Pro Phe Gln Leu Arg Gln Ala 
                245                 250                 255     


Ser Glu Thr Gly Ser Asp Ser Lys Lys Lys Tyr Phe Leu Gln Thr Thr 
            260                 265                 270         


Thr Pro Leu Asp Tyr Glu Lys Val Lys Asp Tyr Thr Ile Glu Ile Val 
        275                 280                 285             


Ala Val Asp Ser Gly Asn Pro Pro Leu Ser Ser Thr Asn Ser Leu Lys 
    290                 295                 300                 


Val Gln Val Val Asp Val Asn Asp Asn Ala Pro Val Phe Thr Gln Ser 
305                 310                 315                 320 


Val Thr Glu Val Ala Phe Pro Glu Asn Asn Lys Pro Gly Glu Val Ile 
                325                 330                 335     


Ala Glu Ile Thr Ala Ser Asp Ala Asp Ser Gly Ser Asn Ala Glu Leu 
            340                 345                 350         


Val Tyr Ser Leu Glu Pro Glu Pro Ala Ala Lys Gly Leu Phe Thr Ile 
        355                 360                 365             


Ser Pro Glu Thr Gly Glu Ile Gln Val Lys Thr Ser Leu Asp Arg Glu 
    370                 375                 380                 


Gln Arg Glu Ser Tyr Glu Leu Lys Val Val Ala Ala Asp Arg Gly Ser 
385                 390                 395                 400 


Pro Ser Leu Gln Gly Thr Ala Thr Val Leu Val Asn Val Leu Asp Cys 
                405                 410                 415     


Asn Asp Asn Asp Pro Lys Phe Met Leu Ser Gly Tyr Asn Phe Ser Val 
            420                 425                 430         


Met Glu Asn Met Pro Ala Leu Ser Pro Val Gly Met Val Thr Val Ile 
        435                 440                 445             


Asp Gly Asp Lys Gly Glu Asn Ala Gln Val Gln Leu Ser Val Glu Gln 
    450                 455                 460                 


Asp Asn Gly Asp Phe Val Ile Gln Asn Gly Thr Gly Thr Ile Leu Ser 
465                 470                 475                 480 


Ser Leu Ser Phe Asp Arg Glu Gln Gln Ser Thr Tyr Thr Phe Gln Leu 
                485                 490                 495     


Lys Ala Val Asp Gly Gly Val Pro Pro Arg Ser Ala Tyr Val Gly Val 
            500                 505                 510         


Thr Ile Asn Val Leu Asp Glu Asn Asp Asn Ala Pro Tyr Ile Thr Ala 
        515                 520                 525             


Pro Ser Asn Thr Ser His Lys Leu Leu Thr Pro Gln Thr Arg Leu Gly 
    530                 535                 540                 


Glu Thr Val Ser Gln Val Ala Ala Glu Asp Phe Asp Ser Gly Val Asn 
545                 550                 555                 560 


Ala Glu Leu Ile Tyr Ser Ile Ala Gly Gly Asn Pro Tyr Gly Leu Phe 
                565                 570                 575     


Gln Ile Gly Ser His Ser Gly Ala Ile Thr Leu Glu Lys Glu Ile Glu 
            580                 585                 590         


Arg Arg His His Gly Leu His Arg Leu Val Val Lys Val Ser Asp Arg 
        595                 600                 605             


Gly Lys Pro Pro Arg Tyr Gly Thr Ala Leu Val His Leu Tyr Val Asn 
    610                 615                 620                 


Glu Thr Leu Ala Asn Arg Thr Leu Leu Glu Thr Leu Leu Gly His Ser 
625                 630                 635                 640 


Leu Asp Thr Pro Leu Asp Ile Asp Ile Ala Gly Asp Pro Glu Tyr Glu 
                645                 650                 655     


Arg Ser Lys Gln Arg Gly 
            660         


<210>  4
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  4

Thr Arg Val Val Tyr Lys Val Pro Glu Glu Gln Pro Pro Asn Thr Leu 
1               5                   10                  15      


Ile Gly Ser Leu Ala Ala Asp Tyr Gly Phe Pro Asp Val Gly His Leu 
            20                  25                  30          


Tyr Lys Leu Glu Val Gly Ala Pro Tyr Leu Arg Val Asp Gly Lys Thr 
        35                  40                  45              


Gly Asp Ile Phe Thr Thr Glu Thr Ser Ile Asp Arg Glu Gly Leu Arg 
    50                  55                  60                  


Glu Cys Gln Asn Gln Leu Pro Gly Asp Pro Cys Ile Leu Glu Phe Glu 
65                  70                  75                  80  


Val Ser Ile Thr Asp Leu Val Gln Asn Gly Ser Pro Arg Leu Leu Glu 
                85                  90                  95      


Gly Gln Ile Glu Val Gln Asp Ile Asn Asp Asn Thr Pro Asn Phe Ala 
            100                 105                 110         


Ser Pro Val Ile Thr Leu Ala Ile Pro Glu Asn Thr Asn Ile Gly Ser 
        115                 120                 125             


Leu Phe Pro Ile 
    130         


<210>  5
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Ala Leu Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  6
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly His Ser Trp Tyr Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Ala Leu Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  8
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly His Ser Trp Tyr Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  9
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa gtttacgctc tgatcacgtt cggacagggt      300

accaaggtgg agatcaaa                                                    318


<210>  10
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctat tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttctcctt attatggcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggtggt      300

cattcttggt acggtatgga ctactggggt caaggaaccc tggtcaccgt ctcctcg         357


<210>  11
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa gtttacgctc tgatcacgtt cggacagggt      300

accaaggtgg agatcaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             639


<210>  12
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctat tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttctcctt attatggcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggtggt      300

cattcttggt acggtatgga ctactggggt caaggaaccc tggtcaccgt ctcctcggct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  13
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Gly Tyr Ala Leu 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  14
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Tyr Ser 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Tyr Tyr Ser Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  15
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Gly Tyr Ala Leu 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  16
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Tyr Ser 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Tyr Tyr Ser Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  17
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  17
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa cattacggtt acgctctgat cacgttcgga      300

cagggtacca aggtggagat caaa                                             324


<210>  18
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  18
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctct tattcttata tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttattctt attatagcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggttct      300

tacggtatgg actactgggg tcaaggaacc ctggtcaccg tctcctcg                   348


<210>  19
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  19
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa cattacggtt acgctctgat cacgttcgga      300

cagggtacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  20
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctct tattcttata tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttattctt attatagcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggttct      300

tacggtatgg actactgggg tcaaggaacc ctggtcaccg tctcctcggc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  21
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gly Tyr Tyr Tyr Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  22
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Pro Tyr Tyr Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly His Ser Trp Ala Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  23
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gly Tyr Tyr Tyr Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  24
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Pro Tyr Tyr Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly His Ser Trp Ala Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  25
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  25
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa ggtggttact actacccgat cacgttcgga      300

cagggtacca aggtggagat caaa                                             324


<210>  26
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctct tattattcta tccactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttatcctt attatggctc tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggtggt      300

cattcttggg ctggttttga ctactggggt caaggaaccc tggtcaccgt ctcctcg         357


<210>  27
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  27

Gly Ala Thr Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      


Ala Gly Thr Cys Cys Cys Cys Gly Ala Gly Cys Thr Cys Cys Cys Thr 
            20                  25                  30          


Gly Thr Cys Cys Gly Cys Cys Thr Cys Thr Gly Thr Gly Gly Gly Cys 
        35                  40                  45              


Gly Ala Thr Ala Gly Gly Gly Thr Cys Ala Cys Cys Ala Thr Cys Ala 
    50                  55                  60                  


Cys Cys Thr Gly Cys Cys Gly Thr Gly Cys Cys Ala Gly Thr Cys Ala 
65                  70                  75                  80  


Gly Thr Cys Cys Gly Thr Gly Thr Cys Cys Ala Gly Cys Gly Cys Thr 
                85                  90                  95      


Gly Thr Ala Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala Ala Cys 
            100                 105                 110         


Ala Gly Ala Ala Ala Cys Cys Ala Gly Gly Ala Ala Ala Ala Gly Cys 
        115                 120                 125             


Thr Cys Cys Gly Ala Ala Gly Cys Thr Thr Cys Thr Gly Ala Thr Thr 
    130                 135                 140                 


Thr Ala Cys Thr Cys Gly Gly Cys Ala Thr Cys Cys Ala Gly Cys Cys 
145                 150                 155                 160 


Thr Cys Thr Ala Cys Thr Cys Thr Gly Gly Ala Gly Thr Cys Cys Cys 
                165                 170                 175     


Thr Thr Cys Thr Cys Gly Cys Thr Thr Cys Thr Cys Thr Gly Gly Thr 
            180                 185                 190         


Ala Gly Cys Cys Gly Thr Thr Cys Cys Gly Gly Gly Ala Cys Gly Gly 
        195                 200                 205             


Ala Thr Thr Thr Cys Ala Cys Thr Cys Thr Gly Ala Cys Cys Ala Thr 
    210                 215                 220                 


Cys Ala Gly Cys Ala Gly Thr Cys Thr Gly Cys Ala Gly Cys Cys Gly 
225                 230                 235                 240 


Gly Ala Ala Gly Ala Cys Thr Thr Cys Gly Cys Ala Ala Cys Thr Thr 
                245                 250                 255     


Ala Thr Thr Ala Cys Thr Gly Thr Cys Ala Gly Cys Ala Ala Gly Gly 
            260                 265                 270         


Thr Gly Gly Thr Thr Ala Cys Thr Ala Cys Thr Ala Cys Cys Cys Gly 
        275                 280                 285             


Ala Thr Cys Ala Cys Gly Thr Thr Cys Gly Gly Ala Cys Ala Gly Gly 
    290                 295                 300                 


Gly Thr Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Gly Ala Thr 
305                 310                 315                 320 


Cys Ala Ala Ala Cys Gly Thr Ala Cys Gly Gly Thr Gly Gly Cys Thr 
                325                 330                 335     


Gly Cys Ala Cys Cys Ala Thr Cys Thr Gly Thr Cys Thr Thr Cys Ala 
            340                 345                 350         


Thr Cys Thr Thr Cys Cys Cys Gly Cys Cys Ala Thr Cys Thr Gly Ala 
        355                 360                 365             


Thr Gly Ala Gly Cys Ala Gly Thr Thr Gly Ala Ala Ala Thr Cys Thr 
    370                 375                 380                 


Gly Gly Ala Ala Cys Thr Gly Cys Cys Thr Cys Thr Gly Thr Thr Gly 
385                 390                 395                 400 


Thr Gly Thr Gly Cys Cys Thr Gly Cys Thr Gly Ala Ala Thr Ala Ala 
                405                 410                 415     


Cys Thr Thr Cys Thr Ala Thr Cys Cys Cys Ala Gly Ala Gly Ala Gly 
            420                 425                 430         


Gly Cys Cys Ala Ala Ala Gly Thr Ala Cys Ala Gly Thr Gly Gly Ala 
        435                 440                 445             


Ala Gly Gly Thr Gly Gly Ala Thr Ala Ala Cys Gly Cys Cys Cys Thr 
    450                 455                 460                 


Cys Cys Ala Ala Thr Cys Gly Gly Gly Thr Ala Ala Cys Thr Cys Cys 
465                 470                 475                 480 


Cys Ala Gly Gly Ala Gly Ala Gly Thr Gly Thr Cys Ala Cys Ala Gly 
                485                 490                 495     


Ala Gly Cys Ala Gly Gly Ala Cys Ala Gly Cys Ala Ala Gly Gly Ala 
            500                 505                 510         


Cys Ala Gly Cys Ala Cys Cys Thr Ala Cys Ala Gly Cys Cys Thr Cys 
        515                 520                 525             


Ala Gly Cys Ala Gly Cys Ala Cys Cys Cys Thr Gly Ala Cys Gly Cys 
    530                 535                 540                 


Thr Gly Ala Gly Cys Ala Ala Ala Gly Cys Ala Gly Ala Cys Thr Ala 
545                 550                 555                 560 


Cys Gly Ala Gly Ala Ala Ala Cys Ala Cys Ala Ala Ala Gly Thr Cys 
                565                 570                 575     


Thr Ala Cys Gly Cys Cys Thr Gly Cys Gly Ala Ala Gly Thr Cys Ala 
            580                 585                 590         


Cys Cys Cys Ala Thr Cys Ala Gly Gly Gly Cys Cys Thr Gly Ala Gly 
        595                 600                 605             


Cys Thr Cys Gly Cys Cys Cys Gly Thr Cys Ala Cys Ala Ala Ala Gly 
    610                 615                 620                 


Ala Gly Cys Thr Thr Cys Ala Ala Cys Ala Gly Gly Gly Gly Ala Gly 
625                 630                 635                 640 


Ala Gly Thr Gly Thr 
                645 


<210>  28
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  28
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctct tattattcta tccactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttatcctt attatggctc tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggtggt      300

cattcttggg ctggttttga ctactggggt caaggaaccc tggtcaccgt ctcctcggct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  29
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Pro Ser Phe Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  30
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Tyr Tyr Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly His His Trp Val Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  31
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Pro Ser Phe Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  32
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Tyr Tyr Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly His His Trp Val Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  33
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  33
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa ggtgttccgt ctttcccgat cacgttcgga      300

cagggtacca aggtggagat caaa                                             324


<210>  34
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  34
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctat tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttctcctt attatagcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggtggt      300

catcattggg ttggtatgga ctactggggt caaggaaccc tggtcaccgt ctcctcg         357


<210>  35
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  35
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa ggtgttccgt ctttcccgat cacgttcgga      300

cagggtacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  36
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  36
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctat tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttctcctt attatagcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggtggt      300

catcattggg ttggtatgga ctactggggt caaggaaccc tggtcaccgt ctcctcggct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  37
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Gly Tyr Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  38
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Pro Tyr Tyr Ser Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  39
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Gly Tyr Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  40
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Pro Tyr Tyr Ser Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  41
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  41
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa cattacggtt actctccgat cacgttcgga      300

cagggtacca aggtggagat caaa                                             324


<210>  42
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  42
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctat tcttattata tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttatcctt attatagcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggtggt      300

tacggtttgg actactgggg tcaaggaacc ctggtcaccg tctcctcg                   348


<210>  43
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  43
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa cattacggtt actctccgat cacgttcgga      300

cagggtacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  44
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  44
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctat tcttattata tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttatcctt attatagcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggtggt      300

tacggtttgg actactgggg tcaaggaacc ctggtcaccg tctcctcggc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  45
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Gly Tyr Val Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  46
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Ser Ser 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Ser Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Tyr Ser His Gly Gly Ala Phe Val Val His Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  47
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Gly Tyr Val Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  48
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Ser Ser 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Ser Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Tyr Ser His Gly Gly Ala Phe Val Val His Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  49
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  49
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa ggtgttggtt acgttccgat cacgttcgga      300

cagggtacca aggtggagat caaa                                             324


<210>  50
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  50
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctat tcttcttcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttattctt cttatggcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctacggt      300

tactctcatg gtggtgcttt cgttgttcat gctatggact actggggtca aggaaccctg      360

gtcaccgtct cctcg                                                       375


<210>  51
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  51
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa ggtgttggtt acgttccgat cacgttcgga      300

cagggtacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  52
<211>  1365
<212>  DNA
<213>  synthetic construct

<400>  52
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctat tcttcttcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttattctt cttatggcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctacggt      300

tactctcatg gtggtgcttt cgttgttcat gctatggact actggggtca aggaaccctg      360

gtcaccgtct cctcggctag caccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1365


<210>  53
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  53

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Trp Ser Tyr Ser Pro 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  54
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Tyr Tyr Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Ser Gly Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  55
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  55

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Trp Ser Tyr Ser Pro 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  56
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Tyr Tyr Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Ser Gly Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  57
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  57
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa tcttggtctt actctccgtt cacgttcgga      300

cagggtacca aggtggagat caaa                                             324


<210>  58
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  58
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctat tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatat atttcttctt attatagcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctactac      300

tctggtggtg gtttggacta ctggggtcaa ggaaccctgg tcaccgtctc ctcg            354


<210>  59
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  59
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa tcttggtctt actctccgtt cacgttcgga      300

cagggtacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  60
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  60
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctat tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatat atttcttctt attatagcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctactac      300

tctggtggtg gtttggacta ctggggtcaa ggaaccctgg tcaccgtctc ctcggctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  61

Gln Ser Val Ser Ser Ala 
1               5       


<210>  62
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  62

Ser Ala Ser 
1           


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  63

Gln Gln Val Tyr Ala Leu Ile Thr 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  64

Gly Phe Asn Leu Tyr Tyr Tyr Ser 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  65

Ile Ser Pro Tyr Tyr Gly Tyr Thr 
1               5               


<210>  66
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  66

Ala Arg Gly Gly His Ser Trp Tyr Gly Met Asp Tyr 
1               5                   10          


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  67

Gly Phe Asn Gly Phe Asn Leu Tyr Tyr Tyr Ser Met 
1               5                   10          


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  68

Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Tyr 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  69

Gln Gln His Tyr Gly Tyr Ala Leu Ile Thr 
1               5                   10  


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  70

Gly Phe Asn Leu Ser Tyr Ser Tyr 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  71

Ile Tyr Ser Tyr Tyr Ser Tyr Thr 
1               5               


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  72

Ala Arg Gly Ser Tyr Gly Met Asp Tyr 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  73

Gly Phe Asn Leu Ser Tyr Ser Tyr Met 
1               5                   


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  74

Ser Ile Tyr Ser Tyr Tyr Ser Tyr Thr Ser 
1               5                   10  


<210>  75
<211>  10
<212>  PRT
<213>  synthetic construct

<400>  75

Gln Gln Gly Gly Tyr Tyr Tyr Pro Ile Thr 
1               5                   10  


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  76

Gly Phe Asn Ile Ser Tyr Tyr Ser 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  77

Ile Tyr Pro Tyr Tyr Gly Ser Thr 
1               5               


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  78

Ala Arg Gly Gly His Ser Trp Ala Gly Phe Asp Tyr 
1               5                   10          


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct

<400>  79

Gly Phe Asn Ile Ser Tyr Tyr Ser Ile 
1               5                   


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  80

Ser Ile Tyr Pro Tyr Tyr Gly Ser Thr Ser 
1               5                   10  


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  81

Gln Gln Gly Val Pro Ser Phe Pro Ile Thr 
1               5                   10  


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  82

Gly Phe Asn Ile Tyr Tyr Tyr Ser 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  83

Ile Ser Pro Tyr Tyr Ser Tyr Thr 
1               5               


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  84

Ala Arg Gly Gly His His Trp Val Gly Met Asp Tyr 
1               5                   10          


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  85

Gly Phe Asn Ile Tyr Tyr Tyr Ser Met 
1               5                   


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  86

Ser Ile Ser Pro Tyr Tyr Ser Tyr Thr Tyr 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  87

Gln Gln Trp Ser Val Tyr Ser Leu Phe Thr 
1               5                   10  


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  88

Gly Phe Asn Ile Ser Tyr Tyr Tyr 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  89

Ile Tyr Ser Tyr Tyr Gly Tyr Thr 
1               5               


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  90

Ala Arg His Gly Trp Tyr Pro Gly Met Asp Tyr 
1               5                   10      


<210>  91
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  91

Gly Phe Asn Ile Ser Tyr Tyr Tyr Met 
1               5                   


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  92

Ser Ile Tyr Ser Tyr Tyr Gly Tyr Thr Tyr 
1               5                   10  


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  93

Gln Gln Ala Tyr Val Trp Pro Ile Thr 
1               5                   


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  94

Gly Phe Asn Leu Tyr Tyr Tyr Ser 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  95

Ile Tyr Pro Tyr Ser Gly Tyr Thr 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  96

Ala Arg Tyr Tyr Ala Phe Asp Tyr 
1               5               


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  97

Gly Phe Asn Leu Tyr Tyr Tyr Ser Met 
1               5                   


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  98

Ser Ile Tyr Pro Tyr Ser Gly Tyr Thr Ser 
1               5                   10  


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  99

Gln Gln His Tyr Gly Tyr Ser Pro Ile Thr 
1               5                   10  


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  100

Gly Phe Asn Ile Tyr Ser Tyr Tyr 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  101

Ile Tyr Pro Tyr Tyr Ser Tyr Thr 
1               5               


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  102

Ala Arg Gly Gly Tyr Gly Leu Asp Tyr 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  103

Gly Phe Asn Ile Tyr Ser Tyr Tyr Met 
1               5                   


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  104

Ser Ile Tyr Pro Tyr Tyr Ser Tyr Thr Ser 
1               5                   10  


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  105

Gln Gln Trp Phe Ser Pro Ser Pro Ile Thr 
1               5                   10  


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  106

Gly Phe Asn Leu Tyr Tyr Tyr Ser 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  107

Ile Tyr Pro Ser Tyr Gly Tyr Thr 
1               5               


<210>  108
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  108

Ala Arg Ala Tyr Tyr Tyr Ser Val Tyr Val Gly Ser His Tyr Ala Tyr 
1               5                   10                  15      


Ala Ser Ala Met Asp Tyr 
            20          


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  109

Gly Phe Asn Leu Tyr Tyr Tyr Ser Met 
1               5                   


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  110

Ser Ile Tyr Pro Ser Tyr Gly Tyr Thr Ser 
1               5                   10  


<210>  111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  111

Gln Gln Gly Tyr Phe Trp Pro Ile Thr 
1               5                   


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  112

Gly Phe Asn Leu Ser Tyr Tyr Ser 
1               5               


<210>  113
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  113

Ile Ser Pro Tyr Tyr Gly Tyr Thr 
1               5               


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  114

Ala Arg Gly Trp Ala Ile Asp Tyr 
1               5               


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  115

Gly Phe Asn Leu Ser Tyr Tyr Ser Met 
1               5                   


<210>  116
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  116

Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser 
1               5                   10  


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  117

Gln Gln Tyr Tyr Pro Leu Ile Thr 
1               5               


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  118

Gly Phe Asn Leu Ser Tyr Tyr Ser 
1               5               


<210>  119
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  119

Ile Ser Ser Ser Tyr Gly Tyr Thr 
1               5               


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  120

Ala Arg Tyr Trp Ala Met Asp Tyr 
1               5               


<210>  121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  121

Gly Phe Asn Leu Ser Tyr Tyr Ser Ile 
1               5                   


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  122

Ser Ile Ser Ser Ser Tyr Gly Tyr Thr Tyr 
1               5                   10  


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  123

Gln Gln Gly Val Gly Tyr Val Pro Ile Thr 
1               5                   10  


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  124

Gly Phe Asn Leu Tyr Ser Ser Ser 
1               5               


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  125

Ile Tyr Ser Ser Tyr Gly Tyr Thr 
1               5               


<210>  126
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  126

Ala Arg Tyr Gly Tyr Ser His Gly Gly Ala Phe Val Val His Ala Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  127
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  127

Gly Phe Asn Leu Tyr Ser Ser Ser Met 
1               5                   


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  128

Ser Ile Tyr Ser Ser Tyr Gly Tyr Thr Ser 
1               5                   10  


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  129

Gln Gln Ser Trp Ser Tyr Ser Pro Phe Thr 
1               5                   10  


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  130

Gly Phe Asn Leu Tyr Tyr Tyr Ser 
1               5               


<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  131

Ile Ser Ser Tyr Tyr Ser Tyr Thr 
1               5               


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  132

Ala Arg Tyr Tyr Ser Gly Gly Gly Leu Asp Tyr 
1               5                   10      


<210>  133
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  133

Gly Phe Asn Leu Tyr Tyr Tyr Ser Met 
1               5                   


<210>  134
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  134

Tyr Ile Ser Ser Tyr Tyr Ser Tyr Thr Tyr 
1               5                   10  


<210>  135
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  135
cagtccgtgt ccagcgct                                                     18


<210>  136
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  136
tcggcatcc                                                                9


<210>  137
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  137
cagcaagttt acgctctgat cacg                                              24


<210>  138
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  138
ggcttcaacc tctattatta ttct                                              24


<210>  139
<211>  24
<212>  DNA
<213>  synthetic construct

<400>  139
atttctcctt attatggcta tact                                              24


<210>  140
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  140
gctcgcggtg gtcattcttg gtacggtatg gactac                                 36


<210>  141
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  141

Gly Gly Cys Thr Thr Cys Ala Ala Cys Cys Thr Cys Thr Ala Thr Thr 
1               5                   10                  15      


Ala Thr Thr Ala Thr Thr Cys Thr Ala Thr Gly 
            20                  25          


<210>  142
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  142
tctatttctc cttattatgg ctatacttat                                        30


<210>  143
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  143
cagcaacatt acggttacgc tctgatcacg                                        30


<210>  144
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  144
ggcttcaacc tctcttattc ttat                                              24


<210>  145
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  145
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa tggttctctc cgtctccgat cacgttcgga      300

cagggtacca aggtggagat caaa                                             324


<210>  146
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  146
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctat tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttatcctt cttatggcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcgcttac      300

tactactctg tttacgttgg ttctcattac gcttacgctt ctgctatgga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcg                                          387


<210>  147
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  147
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa tggttctctc cgtctccgat cacgttcgga      300

cagggtacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  148
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  148
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctat tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttatcctt cttatggcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcgcttac      300

tactactctg tttacgttgg ttctcattac gcttacgctt ctgctatgga ctactggggt      360

caaggaaccc tggtcaccgt ctcctcggct agcaccaagg gcccatcggt cttccccctg      420

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      480

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac      540

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg      600

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      660

accaaggtgg acaagaaagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg      720

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      780

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      840

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      900

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      960

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1020

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1080

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1140

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1200

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1260

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1320

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1377


<210>  149
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  149

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Phe Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  150
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Ala Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  151
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  151

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Phe Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  152
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Ala Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  153
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  153
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa ggttacttct ggccgatcac gttcggacag      300

ggtaccaagg tggagatcaa a                                                321


<210>  154
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  154
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctct tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttctcctt attatggcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggttgg      300

gctattgact actggggtca aggaaccctg gtcaccgtct cctcg                      345


<210>  155
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  155
atttattctt attatagcta tact                                              24


<210>  156
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  156
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa ggttacttct ggccgatcac gttcggacag      300

ggtaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  157
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  157
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctct tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttctcctt attatggcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcggttgg      300

gctattgact actggggtca aggaaccctg gtcaccgtct cctcggctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  158
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  158

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Pro Leu Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  159
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Tyr Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Ser Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Trp Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  160
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  160

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Pro Leu Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  161
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Tyr Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Ser Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Trp Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  162
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  162
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa tactacccgc tgatcacgtt cggacagggt      300

accaaggtgg agatcaaa                                                    318


<210>  163
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  163
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctct tattattcta tccactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttcttctt cttatggcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctactgg      300

gctatggact actggggtca aggaaccctg gtcaccgtct cctcg                      345


<210>  164
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  164
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa tactacccgc tgatcacgtt cggacagggt      300

accaaggtgg agatcaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             639


<210>  165
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  165
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctct tattattcta tccactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttcttctt cttatggcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctactgg      300

gctatggact actggggtca aggaaccctg gtcaccgtct cctcggctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  166
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  166
gctcgcggtt cttacggtat ggactac                                           27


<210>  167
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  167
ggcttcaacc tctcttattc ttatatg                                           27


<210>  168
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  168
tctatttatt cttattatag ctatacttct                                        30


<210>  169
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  169
cagcaaggtg gttactacta cccgatcacg                                        30


<210>  170
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  170
ggcttcaaca tctcttatta ttct                                              24


<210>  171
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  171
atttatcctt attatggctc tact                                              24


<210>  172
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  172
gctcgcggtg gtcattcttg ggctggtttt gactac                                 36


<210>  173
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  173
ggcttcaaca tctcttatta ttctatc                                           27


<210>  174
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  174
tctatttatc cttattatgg ctctacttct                                        30


<210>  175
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  175
cagcaaggtg ttccgtcttt cccgatcacg                                        30


<210>  176
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  176
ggcttcaaca tctattatta ttct                                              24


<210>  177
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  177
atttctcctt attatagcta tact                                              24


<210>  178
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  178
gctcgcggtg gtcatcattg ggttggtatg gactac                                 36


<210>  179
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  179
ggcttcaaca tctattatta ttctatg                                           27


<210>  180
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  180
tctatttctc cttattatag ctatacttat                                        30


<210>  181
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  181
cagcaatggt ctgtttactc tctgttcacg                                        30


<210>  182
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  182
ggcttcaaca tctcttatta ttat                                              24


<210>  183
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  183
atttattctt attatggcta tact                                              24


<210>  184
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  184
gctcgccatg gttggtaccc gggtatggac tac                                    33


<210>  185
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  185
ggcttcaaca tctcttatta ttatatg                                           27


<210>  186
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  186
tctatttatt cttattatgg ctatacttat                                        30


<210>  187
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  187
cagcaagctt acgtttggcc gatcacg                                           27


<210>  188
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  188
ggcttcaacc tctattatta ttct                                              24


<210>  189
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  189
atttatcctt attctggcta tact                                              24


<210>  190
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  190
gctcgctact acgcttttga ctac                                              24


<210>  191
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  191
ggcttcaacc tctattatta ttctatg                                           27


<210>  192
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  192
tctatttatc cttattctgg ctatacttct                                        30


<210>  193
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  193
cagcaacatt acggttactc tccgatcacg                                        30


<210>  194
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  194
ggcttcaaca tctattctta ttat                                              24


<210>  195
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  195
atttatcctt attatagcta tact                                              24


<210>  196
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  196
gctcgcggtg gttacggttt ggactac                                           27


<210>  197
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  197
ggcttcaaca tctattctta ttatatg                                           27


<210>  198
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  198
tctatttatc cttattatag ctatacttct                                        30


<210>  199
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  199
cagcaatggt tctctccgtc tccgatcacg                                        30


<210>  200
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  200
ggcttcaacc tctattatta ttct                                              24


<210>  201
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  201
atttatcctt cttatggcta tact                                              24


<210>  202
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  202
gctcgcgctt actactactc tgtttacgtt ggttctcatt acgcttacgc ttctgctatg       60

gactac                                                                  66


<210>  203
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  203
ggcttcaacc tctattatta ttctatg                                           27


<210>  204
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  204
tctatttatc cttcttatgg ctatacttct                                        30


<210>  205
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  205
cagcaaggtt acttctggcc gatcacg                                           27


<210>  206
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  206
ggcttcaacc tctcttatta ttct                                              24


<210>  207
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  207
atttctcctt attatggcta tact                                              24


<210>  208
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  208
gctcgcggtt gggctattga ctac                                              24


<210>  209
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  209
ggcttcaacc tctcttatta ttctatg                                           27


<210>  210
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  210
tctatttctc cttattatgg ctatacttct                                        30


<210>  211
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  211
cagcaatact acccgctgat cacg                                              24


<210>  212
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  212
ggcttcaacc tctcttatta ttct                                              24


<210>  213
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  213
atttcttctt cttatggcta tact                                              24


<210>  214
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  214
gctcgctact gggctatgga ctac                                              24


<210>  215
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  215
ggcttcaacc tctcttatta ttctatc                                           27


<210>  216
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  216
tctatttctt cttcttatgg ctatacttat                                        30


<210>  217
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  217
cagcaaggtg ttggttacgt tccgatcacg                                        30


<210>  218
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  218
ggcttcaacc tctattcttc ttct                                              24


<210>  219
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  219
atttattctt cttatggcta tact                                              24


<210>  220
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  220
gctcgctacg gttactctca tggtggtgct ttcgttgttc atgctatgga ctac             54


<210>  221
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  221
ggcttcaacc tctattcttc ttctatg                                           27


<210>  222
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  222
tctatttatt cttcttatgg ctatacttct                                        30


<210>  223
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  223
cagcaatctt ggtcttactc tccgttcacg                                        30


<210>  224
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  224
ggcttcaacc tctattatta ttct                                              24


<210>  225
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  225
atttcttctt attatagcta tact                                              24


<210>  226
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  226
gctcgctact actctggtgg tggtttggac tac                                    33


<210>  227
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  227
ggcttcaacc tctattatta ttctatg                                           27


<210>  228
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  228
tatatttctt cttattatag ctatacttat                                        30


<210>  229
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  229
ccttaggggt cacgggaaac                                                   20


<210>  230
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic contruct

<400>  230
gacaacacac ccaacttcgc                                                   20


<210>  231
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  231
tgcctgtcgt tttacccacc                                                   20


<210>  232
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  232
gggaaaaggg agcttcccac                                                   20


<210>  233
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  233
ggtagtatac aaggtgccag agg                                               23


<210>  234
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  234
gccattctgc acgaggtctg t                                                 21


<210>  235
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  235
gtttgagcgg ccctcctatg agg                                               23


<210>  236
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  236
ccccaagttt gagcggccct cctatgaggc cgaactatc                              39


<210>  237
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n represents a single nucleotide inserted in PCDH1

<400>  237
ccccaagttt gagcggccct cctnatgagg ccgaac                                 36


<210>  238
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  238
cccaggtagt atacaaggtg cagaggaaca                                        30


<210>  239
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  239
ggtagtatac aaggtgc                                                      17


<210>  240
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  240
ggtagtatac aaggtgcag                                                    19


<210>  241
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  241
ggtagtatac aaggtgccag ag                                                22


<210>  242
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  242
ggtagtatac aaggtgcaga gg                                                22


<210>  243
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is Y or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is Y or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Y or S

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is Y or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is Y or S

<400>  243

Gly Phe Asn Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  244
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Y or S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is P or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is Y or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is G or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Y or S

<400>  244

Ile Xaa Xaa Xaa Tyr Xaa Xaa Thr 
1               5               


<210>  245
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  245
gtttgagcgg ccctcctatg agg                                               23


<210>  246
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  246

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Val Tyr Ser Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  247
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  247

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Tyr Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Trp Tyr Pro Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  248
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  248

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Val Tyr Ser Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  249
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  249

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Tyr Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Trp Tyr Pro Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  250
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  250
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa tggtctgttt actctctgtt cacgttcgga      300

cagggtacca aggtggagat caaa                                             324


<210>  251
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  251
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctct tattattata tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttattctt attatggcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgccatggt      300

tggtacccgg gtatggacta ctggggtcaa ggaaccctgg tcaccgtctc ctcg            354


<210>  252
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  252
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa tggtctgttt actctctgtt cacgttcgga      300

cagggtacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  253
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  253
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctct tattattata tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttattctt attatggcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgccatggt      300

tggtacccgg gtatggacta ctggggtcaa ggaaccctgg tcaccgtctc ctcggctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  254
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  254

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Val Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  255
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Pro Tyr Ser Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  256
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  256

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Val Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  257
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  257

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Pro Tyr Ser Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  258
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  258
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa gcttacgttt ggccgatcac gttcggacag      300

ggtaccaagg tggagatcaa a                                                321


<210>  259
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic contruct

<400>  259
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctat tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttatcctt attctggcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctactac      300

gcttttgact actggggtca aggaaccctg gtcaccgtct cctcg                      345


<210>  260
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  260
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa gcttacgttt ggccgatcac gttcggacag      300

ggtaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  261
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  261
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctat tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttatcctt attctggcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctactac      300

gcttttgact actggggtca aggaaccctg gtcaccgtct cctcggctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  262
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  262

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Phe Ser Pro Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  263
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  263

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Pro Ser Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Tyr Ser Val Tyr Val Gly Ser His Tyr Ala Tyr 
            100                 105                 110         


Ala Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  264
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  264

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Phe Ser Pro Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  265
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  265

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Pro Ser Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Tyr Ser Val Tyr Val Gly Ser His Tyr Ala Tyr 
            100                 105                 110         


Ala Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 


