                         SEQUENCE LISTING

<110>  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO; F. HOFFMANN-LA ROCHE LTD. 
 
<120>  METHODS OF TREATING AN AUTOIMMUNE DISEASE

<130>  38754-2027

<140>  PCT/CA2019/051653 
<141>  2019-11-20

<150>  US 62/770,408
<151>  2018-11-21

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210>  2
<211>  2665
<212>  DNA
<213>  Homo sapiens

<400>  2
gaaattctta caaaaactga aagtgaaatg aggaagacag attgagcaat ccaatcggag       60

ggtaaatgcc agcaaaccta ctgtacagta ggggtagaga tgcagaaagg cagaaaggag      120

aaaattcagg ataactctcc tgaggggtga gccaagccct gccatgtagt gcacgcagga      180

catcaacaaa cacagataac aggaaatgat ccattccctg tggtcactta ttctaaaggc      240

cccaaccttc aaagttcaag tagtgatatg gatgactcca cagaaaggga gcagtcacgc      300

cttacttctt gccttaagaa aagagaagaa atgaaactga aggagtgtgt ttccatcctc      360

ccacggaagg aaagcccctc tgtccgatcc tccaaagacg gaaagctgct ggctgcaacc      420

ttgctgctgg cactgctgtc ttgctgcctc acggtggtgt ctttctacca ggtggccgcc      480

ctgcaagggg acctggccag cctccgggca gagctgcagg gccaccacgc ggagaagctg      540

ccagcaggag caggagcccc caaggccggc ctggaggaag ctccagctgt caccgcggga      600

ctgaaaatct ttgaaccacc agctccagga gaaggcaact ccagtcagaa cagcagaaat      660

aagcgtgccg ttcagggtcc agaagaaaca gtcactcaag actgcttgca actgattgca      720

gacagtgaaa caccaactat acaaaaagga tcttacacat ttgttccatg gcttctcagc      780

tttaaaaggg gaagtgccct agaagaaaaa gagaataaaa tattggtcaa agaaactggt      840

tactttttta tatatggtca ggttttatat actgataaga cctacgccat gggacatcta      900

attcagagga agaaggtcca tgtctttggg gatgaattga gtctggtgac tttgtttcga      960

tgtattcaaa atatgcctga aacactaccc aataattcct gctattcagc tggcattgca     1020

aaactggaag aaggagatga actccaactt gcaataccaa gagaaaatgc acaaatatca     1080

ctggatggag atgtcacatt ttttggtgca ttgaaactgc tgtgacctac ttacaccatg     1140

tctgtagcta ttttcctccc tttctctgta cctctaagaa gaaagaatct aactgaaaat     1200

accaaaaaaa aaaaaaaaaa aaaagtagtt accattgcct tttctgtgag ctatttgttt     1260

tggtttgctg aaactagtcc aaaacaggaa atttaacaga cagccacagc caaagagtgt     1320

catgtgaatt acaagaaata gagcccattt agggaaagat agaactagaa aggcttttca     1380

ttataattcc atgttgaaca attgagtcat agcttcttat cttggaggaa ggacacaatt     1440

caaaggggca gtaaggattt tgtaaaacgt ggcatccata atttactatg gagcaagtgc     1500

ccacatctct aggacattaa gacatttatg agaaatctca ggattcatct tctgttttta     1560

tgttaaatgc actccctcct tttcagttaa cattataaaa agtaaaaaat gaaaatttta     1620

gaaatcttgc attagacaca tgaaaaaata actaaaagtt taaatttaaa tatgaaacaa     1680

ttttgctgaa aatagtatcc atatactatt taagtctttt atggttattt caagtataca     1740

atttctatct gtaatgtaat atattaccca cacatttttt tcacaggaga gagagaatat     1800

cctcatttgt ttatgctcat gtgtattttc tatagtgaat ttcagaaact tttaatatca     1860

ggtaatttca atttatgcct ataaagcatt gattgaaaaa taactagaat tgtgcatata     1920

taacacataa tctccaacag aagttactga atacattcat actaatgtaa tgtaatttcc     1980

ctttatttct tgctcttctg tttcaaactg ctgctattgt agtttacata tcccaacctt     2040

taaaaatatt cctcttatta gctttatatt cactttatag aagttgagtt ttaattaaaa     2100

ttcttggcat cctgaagtat gtcacatagc atgtgctcct tataaatatg ttgatatctc     2160

agaagacagc atcccggttt tcattttata aagtaccata cttaagaatg ctgtaatact     2220

tatcttttat aacatgtttc cttcgctttg cttgtctttt atgtcatcag ttttaactgt     2280

ttacttcatt taacagttta catcattcaa cagtttactt cattaaacag taggtggaaa     2340

aatagatgcc agtctatgaa aatcttccca tctatatcaa aatacttttc aaggatatac     2400

ttttcaaaac aaacgattta aattttatgt ttaaaatata aactttagat ttaaacttta     2460

tttaaatatc tggttcctat gattttgact tcagtaagtt caaataaaat atattttgca     2520

attcattttt acattataat ttaaaaagaa gaagcgataa gtggagtcag tttcaatgct     2580

aggtggggtg gttaatgatt tttctggtgt tgctgctaat gtggattaac aaataaaaac     2640

attcattgcc ttttgcctca taaaa                                           2665


<210>  3
<211>  309
<212>  PRT
<213>  Mus musculus

<400>  3

Met Asp Glu Ser Ala Lys Thr Leu Pro Pro Pro Cys Leu Cys Phe Cys 
1               5                   10                  15      


Ser Glu Lys Gly Glu Asp Met Lys Val Gly Tyr Asp Pro Ile Thr Pro 
            20                  25                  30          


Gln Lys Glu Glu Gly Ala Trp Phe Gly Ile Cys Arg Asp Gly Arg Leu 
        35                  40                  45              


Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Ser Ser Phe Thr Ala 
    50                  55                  60                  


Met Ser Leu Tyr Gln Leu Ala Ala Leu Gln Ala Asp Leu Met Asn Leu 
65                  70                  75                  80  


Arg Met Glu Leu Gln Ser Tyr Arg Gly Ser Ala Thr Pro Ala Ala Ala 
                85                  90                  95      


Gly Ala Pro Glu Leu Thr Ala Gly Val Lys Leu Leu Thr Pro Ala Ala 
            100                 105                 110         


Pro Arg Pro His Asn Ser Ser Arg Gly His Arg Asn Arg Arg Ala Phe 
        115                 120                 125             


Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala Pro Pro 
    130                 135                 140                 


Ala Pro Cys Leu Pro Gly Cys Arg His Ser Gln His Asp Asp Asn Gly 
145                 150                 155                 160 


Met Asn Leu Arg Asn Ile Ile Gln Asp Cys Leu Gln Leu Ile Ala Asp 
                165                 170                 175     


Ser Asp Thr Pro Thr Ile Arg Lys Gly Thr Tyr Thr Phe Val Pro Trp 
            180                 185                 190         


Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys 
        195                 200                 205             


Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu 
    210                 215                 220                 


Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys 
225                 230                 235                 240 


Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys 
                245                 250                 255     


Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala 
            260                 265                 270         


Gly Ile Ala Arg Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro 
        275                 280                 285             


Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly 
    290                 295                 300                 


Ala Leu Lys Leu Leu 
305                 


<210>  4
<211>  1699
<212>  DNA
<213>  Mus musculus

<400>  4
aggcagattg agcaatccat ggaaggccag agccagagaa cctacttcag ggtagcaaaa       60

gatgcagaag aaagtcagga gagcgctcct gggggaaccc agccctgcca tgctctgagg      120

gcagtctccc aggacacaga tgacaggaaa tgacccaccc ctgtggtcac ttactccaaa      180

ggcctagacc ttcaaagtgc tcctcgtgga atggatgagt ctgcaaagac cctgccacca      240

ccgtgcctct gtttttgctc cgagaaagga gaagatatga aagtgggata tgatcccatc      300

actccgcaga aggaggaggg tgcctggttt gggatctgca gggatggaag gctgctggct      360

gctaccctcc tgctggccct gttgtccagc agtttcacag cgatgtcctt gtaccagttg      420

gctgccttgc aagcagacct gatgaacctg cgcatggagc tgcagagcta ccgaggttca      480

gcaacaccag ccgccgcggg tgctccagag ttgaccgctg gagtcaaact cctgacaccg      540

gcagctcctc gaccccacaa ctccagccgc ggccacagga acagacgcgc tttccaggga      600

ccagaggaaa cagaacaaga tgtagacctc tcagctcctc ctgcaccatg cctgcctgga      660

tgccgccatt ctcaacatga tgataatgga atgaacctca gaaacatcat tcaagactgt      720

ctgcagctga ttgcagacag cgacacgccg actatacgaa aaggaactta cacatttgtt      780

ccatggcttc tcagctttaa aagaggaaat gccttggagg agaaagagaa caaaatagtg      840

gtgaggcaaa caggctattt cttcatctac agccaggttc tatacacgga ccccatcttt      900

gctatgggtc atgtcatcca gaggaagaaa gtacacgtct ttggggacga gctgagcctg      960

gtgaccctgt tccgatgtat tcagaatatg cccaaaacac tgcccaacaa ttcctgctac     1020

tcggctggca tcgcgaggct ggaagaagga gatgagattc agcttgcaat tcctcgggag     1080

aatgcacaga tttcacgcaa cggagacgac accttctttg gtgccctaaa actgctgtaa     1140

ctcacttgct ggagtgcgtg atccccttcc ctcgtcttct ctgtacctcc gagggagaaa     1200

cagacgactg gaaaaactaa aagatgggga aagccgtcag cgaaagtttt ctcgtgaccc     1260

gttgaatctg atccaaacca ggaaatataa cagacagcca caaccgaagt gtgccatgtg     1320

agttatgaga aacggagccc gcgctcagaa agaccggatg aggaagaccg ttttctccag     1380

tcctttgcca acacgcaccg caaccttgct ttttgccttg ggtgacacat gttcagaatg     1440

cagggagatt tccttgtttt gcgatttgcc atgagaagag ggcccacaac tgcaggtcac     1500

tgaagcattc acgctaagtc tcaggattta ctctcccttc tcatgctaag tacacacacg     1560

ctcttttcca ggtaatacta tgggatacta tggaaaggtt gtttgttttt aaatctagaa     1620

gtcttgaact ggcaatagac aaaaatcctt ataaattcaa gtgtaaaata aacttaatta     1680

aaaaggttta agtgtgaaa                                                  1699


