                         SEQUENCE LISTING

<110>  Yale University
 
<120>  MANIPULATION OF MENINGEAL LYMPHATIC VASCULATURE FOR BRAIN AND CNS
        TUMOR THERAPY

<130>  251609.000023

<150>  US 62/768,390
<151>  2018-11-16

<150>  US 62/929,527
<151>  2019-11-01

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Leu Leu Gly Phe Phe Ser Val Ala Cys Ser Leu Leu Ala Ala 
1               5                   10                  15      


Ala Leu Leu Pro Gly Pro Arg Glu Ala Pro Ala Ala Ala Ala Ala Phe 
            20                  25                  30          


Glu Ser Gly Leu Asp Leu Ser Asp Ala Glu Pro Asp Ala Gly Glu Ala 
        35                  40                  45              


Thr Ala Tyr Ala Ser Lys Asp Leu Glu Glu Gln Leu Arg Ser Val Ser 
    50                  55                  60                  


Ser Val Asp Glu Leu Met Thr Val Leu Tyr Pro Glu Tyr Trp Lys Met 
65                  70                  75                  80  


Tyr Lys Cys Gln Leu Arg Lys Gly Gly Trp Gln His Asn Arg Glu Gln 
                85                  90                  95      


Ala Asn Leu Asn Ser Arg Thr Glu Glu Thr Ile Lys Phe Ala Ala Ala 
            100                 105                 110         


His Tyr Asn Thr Glu Ile Leu Lys Ser Ile Asp Asn Glu Trp Arg Lys 
        115                 120                 125             


Thr Gln Cys Met Pro Arg Glu Val Cys Ile Asp Val Gly Lys Glu Phe 
    130                 135                 140                 


Gly Val Ala Thr Asn Thr Phe Phe Lys Pro Pro Cys Val Ser Val Tyr 
145                 150                 155                 160 


Arg Cys Gly Gly Cys Cys Asn Ser Glu Gly Leu Gln Cys Met Asn Thr 
                165                 170                 175     


Ser Thr Ser Tyr Leu Ser Lys Thr Leu Phe Glu Ile Thr Val Pro Leu 
            180                 185                 190         


Ser Gln Gly Pro Lys Pro Val Thr Ile Ser Phe Ala Asn His Thr Ser 
        195                 200                 205             


Cys Arg Cys Met Ser Lys Leu Asp Val Tyr Arg Gln Val His Ser Ile 
    210                 215                 220                 


Ile Arg Arg Ser Leu Pro Ala Thr Leu Pro Gln Cys Gln Ala Ala Asn 
225                 230                 235                 240 


Lys Thr Cys Pro Thr Asn Tyr Met Trp Asn Asn His Ile Cys Arg Cys 
                245                 250                 255     


Leu Ala Gln Glu Asp Phe Met Phe Ser Ser Asp Ala Gly Asp Asp Ser 
            260                 265                 270         


Thr Asp Gly Phe His Asp Ile Cys Gly Pro Asn Lys Glu Leu Asp Glu 
        275                 280                 285             


Glu Thr Cys Gln Cys Val Cys Arg Ala Gly Leu Arg Pro Ala Ser Cys 
    290                 295                 300                 


Gly Pro His Lys Glu Leu Asp Arg Asn Ser Cys Gln Cys Val Cys Lys 
305                 310                 315                 320 


Asn Lys Leu Phe Pro Ser Gln Cys Gly Ala Asn Arg Glu Phe Asp Glu 
                325                 330                 335     


Asn Thr Cys Gln Cys Val Cys Lys Arg Thr Cys Pro Arg Asn Gln Pro 
            340                 345                 350         


Leu Asn Pro Gly Lys Cys Ala Cys Glu Cys Thr Glu Ser Pro Gln Lys 
        355                 360                 365             


Cys Leu Leu Lys Gly Lys Lys Phe His His Gln Thr Cys Ser Cys Tyr 
    370                 375                 380                 


Arg Arg Pro Cys Thr Asn Arg Gln Lys Ala Cys Glu Pro Gly Phe Ser 
385                 390                 395                 400 


Gln Pro Leu Asn Pro Gly Lys Cys Ala Cys Glu Cys Thr Glu Ser Pro 
                405                 410                 415     


Gln Lys Cys Leu Leu Lys Gly Lys Lys Phe His His Gln Thr Cys Ser 
            420                 425                 430         


Cys Tyr Arg Arg Pro Cys Thr Asn Arg Gln Lys Ala Cys Glu Pro Gly 
        435                 440                 445             


Phe Ser 
    450 


<210>  2
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys 
            340                 345                 350         


Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser 
        355                 360                 365             


Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys 
    370                 375                 380                 


Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu 
385                 390                 395                 400 


Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
                405                 410         


<210>  3
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Pro Leu Leu Arg Arg Leu Leu Leu Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Ala Pro Ala Gln Ala Pro Val Ser Gln Pro Asp Ala Pro Gly His Gln 
            20                  25                  30          


Arg Lys Val Val Ser Trp Ile Asp Val Tyr Thr Arg Ala Thr Cys Gln 
        35                  40                  45              


Pro Arg Glu Val Val Val Pro Leu Thr Val Glu Leu Met Gly Thr Val 
    50                  55                  60                  


Ala Lys Gln Leu Val Pro Ser Cys Val Thr Val Gln Arg Cys Gly Gly 
65                  70                  75                  80  


Cys Cys Pro Asp Asp Gly Leu Glu Cys Val Pro Thr Gly Gln His Gln 
                85                  90                  95      


Val Arg Met Gln Ile Leu Met Ile Arg Tyr Pro Ser Ser Gln Leu Gly 
            100                 105                 110         


Glu Met Ser Leu Glu Glu His Ser Gln Cys Glu Cys Arg Pro Lys Lys 
        115                 120                 125             


Lys Asp Ser Ala Val Lys Pro Asp Arg Ala Ala Thr Pro His His Arg 
    130                 135                 140                 


Pro Gln Pro Arg Ser Val Pro Gly Trp Asp Ser Ala Pro Gly Ala Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Ile Thr His Pro Thr Pro Ala Pro Gly Pro Ser Ala 
                165                 170                 175     


His Ala Ala Pro Ser Thr Thr Ser Ala Leu Thr Pro Gly Pro Ala Ala 
            180                 185                 190         


Ala Ala Ala Asp Ala Ala Ala Ser Ser Val Ala Lys Gly Gly Ala 
        195                 200                 205         


<210>  4
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Tyr Arg Glu Trp Val Val Val Asn Val Phe Met Met Leu Tyr Val 
1               5                   10                  15      


Gln Leu Val Gln Gly Ser Ser Asn Glu His Gly Pro Val Lys Arg Ser 
            20                  25                  30          


Ser Gln Ser Thr Leu Glu Arg Ser Glu Gln Gln Ile Arg Ala Ala Ser 
        35                  40                  45              


Ser Leu Glu Glu Leu Leu Arg Ile Thr His Ser Glu Asp Trp Lys Leu 
    50                  55                  60                  


Trp Arg Cys Arg Leu Arg Leu Lys Ser Phe Thr Ser Met Asp Ser Arg 
65                  70                  75                  80  


Ser Ala Ser His Arg Ser Thr Arg Phe Ala Ala Thr Phe Tyr Asp Ile 
                85                  90                  95      


Glu Thr Leu Lys Val Ile Asp Glu Glu Trp Gln Arg Thr Gln Cys Ser 
            100                 105                 110         


Pro Arg Glu Thr Cys Val Glu Val Ala Ser Glu Leu Gly Lys Ser Thr 
        115                 120                 125             


Asn Thr Phe Phe Lys Pro Pro Cys Val Asn Val Phe Arg Cys Gly Gly 
    130                 135                 140                 


Cys Cys Asn Glu Glu Ser Leu Ile Cys Met Asn Thr Ser Thr Ser Tyr 
145                 150                 155                 160 


Ile Ser Lys Gln Leu Phe Glu Ile Ser Val Pro Leu Thr Ser Val Pro 
                165                 170                 175     


Glu Leu Val Pro Val Lys Val Ala Asn His Thr Gly Cys Lys Cys Leu 
            180                 185                 190         


Pro Thr Ala Pro Arg His Pro Tyr Ser Ile Ile Arg Arg Ser Ile Gln 
        195                 200                 205             


Ile Pro Glu Glu Asp Arg Cys Ser His Ser Lys Lys Leu Cys Pro Ile 
    210                 215                 220                 


Asp Met Leu Trp Asp Ser Asn Lys Cys Lys Cys Val Leu Gln Glu Glu 
225                 230                 235                 240 


Asn Pro Leu Ala Gly Thr Glu Asp His Ser His Leu Gln Glu Pro Ala 
                245                 250                 255     


Leu Cys Gly Pro His Met Met Phe Asp Glu Asp Arg Cys Glu Cys Val 
            260                 265                 270         


Cys Lys Thr Pro Cys Pro Lys Asp Leu Ile Gln His Pro Lys Asn Cys 
        275                 280                 285             


Ser Cys Phe Glu Cys Lys Glu Ser Leu Glu Thr Cys Cys Gln Lys His 
    290                 295                 300                 


Lys Leu Phe His Pro Asp Thr Cys Ser Cys Glu Asp Arg Cys Pro Phe 
305                 310                 315                 320 


His Thr Arg Pro Cys Ala Ser Gly Lys Thr Ala Cys Ala Lys His Cys 
                325                 330                 335     


Arg Phe Pro Lys Glu Lys Arg Ala Ala Gln Gly Pro His Ser Arg Lys 
            340                 345                 350         


Asn Pro 
        


<210>  5
<211>  1248
<212>  DNA
<213>  Homo sapiens

<400>  5
atgcacttgc tgtgcttctt gtctctggcg tgttccctgc tcgccgctgc gctgatcccc       60

agtccgcgcg aggcgcccgc caccgtcgcc gccttcgagt cgggactggg cttctcggaa      120

gcggagcccg acgggggcga ggtcaaggct tttgaaggca aagacctgga ggagcagttg      180

cggtctgtgt ccagcgtaga tgagctgatg tctgtcctgt acccagacta ctggaaaatg      240

tacaagtgcc agctgcggaa aggcggctgg cagcagccca ccctcaatac caggacaggg      300

gacagtgtaa aatttgctgc tgcacattat aacacagaga tcctgaaaag tattgataat      360

gagtggagaa agactcaatg catgccacgt gaggtgtgta tagatgtggg gaaggagttt      420

ggagcagcca caaacacctt ctttaaacct ccatgtgtgt ccgtctacag atgtgggggt      480

tgctgcaaca gcgaggggct gcagtgcatg aacaccagca caggttacct cagcaagacg      540

ttgtttgaaa ttacagtgcc tctctcacaa ggccccaaac cagtcacaat cagttttgcc      600

aatcacactt cctgccggtg catgtctaaa ctggatgttt acagacaagt tcattcaatt      660

attagacgtt ctctgccagc aacattacca cagtgtcagg cagctaacaa gacatgtcca      720

acaaactatg tgtggaataa ctacatgtgc cgatgcctgg ctcagcagga ttttatcttt      780

tattcaaatg ttgaagatga ctcaaccaat ggattccatg atgtctgtgg acccaacaag      840

gagctggatg aagacacctg tcagtgtgtc tgcaaggggg ggcttcggcc atctagttgt      900

ggaccccaca aagaactaga tagagactca tgtcagtgtg tctgtaaaaa caaacttttc      960

cctaattcat gtggagccaa cagggaattt gatgagaata catgtcagtg tgtatgtaaa     1020

agaacgtgtc caagaaatca gcccctgaat cctgggaaat gtgcctgtga atgtacagaa     1080

aacacacaga agtgcttcct taaagggaag aagttccacc atcaaacatg cagttgttac     1140

agaagaccgt gtgcgaatcg actgaagcat tgtgatccag gactgtcctt tagtgaagaa     1200

gtatgccgct gtgtcccatc gtattggaaa aggccacatc tgaactaa                  1248


<210>  6
<211>  1248
<212>  DNA
<213>  Homo sapiens

<400>  6
atgcacttgc tgtgcttctt gtctctggcg tgttccctgc tcgccgctgc gctgatcccc       60

agtccgcgcg aggcgcccgc caccgtcgcc gccttcgagt cgggactggg cttctcggaa      120

gcggagcccg acgggggcga ggtcaaggct tttgaaggca aagacctgga ggagcagttg      180

cggtctgtgt ccagcgtaga tgagctgatg tctgtcctgt acccagacta ctggaaaatg      240

tacaagtgcc agctgcggaa aggcggctgg cagcagccca ccctcaatac caggacaggg      300

gacagtgtaa aatttgctgc tgcacattat aacacagaga tcctgaaaag tattgataat      360

gagtggagaa agactcaatg catgccacgt gaggtgtgta tagatgtggg gaaggagttt      420

ggagcagcca caaacacctt ctttaaacct ccatgtgtgt ccgtctacag atgtgggggt      480

tgctgcaaca gcgaggggct gcagtgcatg aacaccagca caggttacct cagcaagacg      540

ttgtttgaaa ttacagtgcc tctctcacaa ggccccaaac cagtcacaat cagttttgcc      600

aatcacactt cctgccggtg catgtctaaa ctggatgttt acagacaagt tcattcaatt      660

attagacgtt ctctgccagc aacattacca cagtgtcagg cagctaacaa gacatgtcca      720

acaaactatg tgtggaataa ctacatgtgc cgatgcctgg ctcagcagga ttttatcttt      780

tattcaaatg ttgaagatga ctcaaccaat ggattccatg atgtctgtgg acccaacaag      840

gagctggatg aagacacctg tcagtgtgtc tgcaaggggg ggcttcggcc atctagttgt      900

ggaccccaca aagaactaga tagagactca tgtcagtgtg tctgtaaaaa caaacttttc      960

cctaattcat gtggagccaa cagggaattt gatgagaata catgtcagtg tgtatgtaaa     1020

agaacgtgtc caagaaatca gcccctgaat cctgggaaat gtgcctgtga atgtacagaa     1080

aacacacaga agtgcttcct taaagggaag aagttccacc atcaaacatg cagttgttac     1140

agaagaccgt gtgcgaatcg actgaagcat tgtgatccag gactgtcctt tagtgaagaa     1200

gtatgccgct gtgtcccatc gtattggaaa aggccacatc tgaactaa                  1248


<210>  7
<211>  1236
<212>  DNA
<213>  Homo sapiens

<400>  7
ctgacggaca gacagacaga caccgccccc agccccagct accacctcct ccccggccgg       60

cggcggacag tggacgcggc ggcgagccgc gggcaggggc cggagcccgc gcccggaggc      120

ggggtggagg gggtcggggc tcgcggcgtc gcactgaaac ttttcgtcca acttctgggc      180

tgttctcgct tcggaggagc cgtggtccgc gcgggggaag ccgagccgag cggagccgcg      240

agaagtgcta gctcgggccg ggaggagccg cagccggagg agggggagga ggaagaagag      300

aaggaagagg agagggggcc gcagtggcga ctcggcgctc ggaagccggg ctcatggacg      360

ggtgaggcgg cggtgtgcgc agacagtgct ccagccgcgc gcgctcccca ggccctggcc      420

cgggcctcgg gccggggagg aagagtagct cgccgaggcg ccgaggagag cgggccgccc      480

cacagcccga gccggagagg gagcgcgagc cgcgccggcc ccggtcgggc ctccgaaacc      540

atgaactttc tgctgtcttg ggtgcattgg agccttgcct tgctgctcta cctccaccat      600

gccaagtggt cccaggctgc acccatggca gaaggaggag ggcagaatca tcacgaagtg      660

gtgaagttca tggatgtcta tcagcgcagc tactgccatc caatcgagac cctggtggac      720

atcttccagg agtaccctga tgagatcgag tacatcttca agccatcctg tgtgcccctg      780

atgcgatgcg ggggctgctg caatgacgag ggcctggagt gtgtgcccac tgaggagtcc      840

aacatcacca tgcagattat gcggatcaaa cctcaccaag gccagcacat aggagagatg      900

agcttcctac agcacaacaa atgtgaatgc agaccaaaga aagatagagc aagacaagaa      960

aaaaaatcag ttcgaggaaa gggaaagggg caaaaacgaa agcgcaagaa atcccggtat     1020

aagtcctgga gcgtgtacgt tggtgcccgc tgctgtctaa tgccctggag cctccctggc     1080

ccccatccct gtgggccttg ctcagagcgg agaaagcatt tgtttgtaca agatccgcag     1140

acgtgtaaat gttcctgcaa aaacacagac tcgcgttgca aggcgaggca gcttgagtta     1200

aacgaacgta cttgcagatg tgacaagccg aggcgg                               1236


<210>  8
<211>  1236
<212>  DNA
<213>  Homo sapiens

<400>  8
ctgacggaca gacagacaga caccgccccc agccccagct accacctcct ccccggccgg       60

cggcggacag tggacgcggc ggcgagccgc gggcaggggc cggagcccgc gcccggaggc      120

ggggtggagg gggtcggggc tcgcggcgtc gcactgaaac ttttcgtcca acttctgggc      180

tgttctcgct tcggaggagc cgtggtccgc gcgggggaag ccgagccgag cggagccgcg      240

agaagtgcta gctcgggccg ggaggagccg cagccggagg agggggagga ggaagaagag      300

aaggaagagg agagggggcc gcagtggcga ctcggcgctc ggaagccggg ctcatggacg      360

ggtgaggcgg cggtgtgcgc agacagtgct ccagccgcgc gcgctcccca ggccctggcc      420

cgggcctcgg gccggggagg aagagtagct cgccgaggcg ccgaggagag cgggccgccc      480

cacagcccga gccggagagg gagcgcgagc cgcgccggcc ccggtcgggc ctccgaaacc      540

atgaactttc tgctgtcttg ggtgcattgg agccttgcct tgctgctcta cctccaccat      600

gccaagtggt cccaggctgc acccatggca gaaggaggag ggcagaatca tcacgaagtg      660

gtgaagttca tggatgtcta tcagcgcagc tactgccatc caatcgagac cctggtggac      720

atcttccagg agtaccctga tgagatcgag tacatcttca agccatcctg tgtgcccctg      780

atgcgatgcg ggggctgctg caatgacgag ggcctggagt gtgtgcccac tgaggagtcc      840

aacatcacca tgcagattat gcggatcaaa cctcaccaag gccagcacat aggagagatg      900

agcttcctac agcacaacaa atgtgaatgc agaccaaaga aagatagagc aagacaagaa      960

aaaaaatcag ttcgaggaaa gggaaagggg caaaaacgaa agcgcaagaa atcccggtat     1020

aagtcctgga gcgtgtacgt tggtgcccgc tgctgtctaa tgccctggag cctccctggc     1080

ccccatccct gtgggccttg ctcagagcgg agaaagcatt tgtttgtaca agatccgcag     1140

acgtgtaaat gttcctgcaa aaacacagac tcgcgttgca aggcgaggca gcttgagtta     1200

aacgaacgta cttgcagatg tgacaagccg aggcgg                               1236


<210>  9
<211>  435
<212>  DNA
<213>  Homo sapiens

<400>  9
gtctcccagc ctgatgcccc tggccaccag aggaaagtgg tgtcatggat agatgtgtat       60

actcgcgcta cctgccagcc ccgggaggtg gtggtgccct tgactgtgga gctcatgggc      120

accgtggcca aacagctggt gcccagctgc gtgactgtgc agcgctgtgg tggctgctgc      180

cctgacgatg gcctggagtg tgtgcccact gggcagcacc aagtccggat gcagatcctc      240

atgatccggt acccgagcag tcagctgggg gagatgtccc tggaagaaca cagccagtgt      300

gaatgcagac ctaaaaaaaa ggacagtgct gtgaagccag acagggctgc cactccccac      360

caccgtcccc agccccgttc tgttccgggc tgggactctg cccccggagc accctcccca      420

gctgacatca cccat                                                       435


<210>  10
<211>  435
<212>  DNA
<213>  Homo sapiens

<400>  10
gtctcccagc ctgatgcccc tggccaccag aggaaagtgg tgtcatggat agatgtgtat       60

actcgcgcta cctgccagcc ccgggaggtg gtggtgccct tgactgtgga gctcatgggc      120

accgtggcca aacagctggt gcccagctgc gtgactgtgc agcgctgtgg tggctgctgc      180

cctgacgatg gcctggagtg tgtgcccact gggcagcacc aagtccggat gcagatcctc      240

atgatccggt acccgagcag tcagctgggg gagatgtccc tggaagaaca cagccagtgt      300

gaatgcagac ctaaaaaaaa ggacagtgct gtgaagccag acagggctgc cactccccac      360

caccgtcccc agccccgttc tgttccgggc tgggactctg cccccggagc accctcccca      420

gctgacatca cccat                                                       435


<210>  11
<211>  1062
<212>  DNA
<213>  Homo sapiens

<400>  11
atgtacagag agtgggtagt ggtgaatgtt ttcatgatgt tgtacgtcca gctggtgcag       60

ggctccagta atgaacatgg accagtgaag cgatcatctc agtccacatt ggaacgatct      120

gaacagcaga tcagggctgc ttctagtttg gaggaactac ttcgaattac tcactctgag      180

gactggaagc tgtggagatg caggctgagg ctcaaaagtt ttaccagtat ggactctcgc      240

tcagcatccc atcggtccac taggtttgcg gcaactttct atgacattga aacactaaaa      300

gttatagatg aagaatggca aagaactcag tgcagcccta gagaaacgtg cgtggaggtg      360

gccagtgagc tggggaagag taccaacaca ttcttcaagc ccccttgtgt gaacgtgttc      420

cgatgtggtg gctgttgcaa tgaagagagc cttatctgta tgaacaccag cacctcgtac      480

atttccaaac agctctttga gatatcagtg cctttgacat cagtacctga attagtgcct      540

gttaaagttg ccaatcatac aggttgtaag tgcttgccaa cagccccccg ccatccatac      600

tcaattatca gaagatccat ccagatccct gaagaagatc gctgttccca ttccaagaaa      660

ctctgtccta ttgacatgct atgggatagc aacaaatgta aatgtgtttt gcaggaggaa      720

aatccacttg ctggaacaga agaccactct catctccagg aaccagctct ctgtgggcca      780

cacatgatgt ttgacgaaga tcgttgcgag tgtgtctgta aaacaccatg tcccaaagat      840

ctaatccagc accccaaaaa ctgcagttgc tttgagtgca aagaaagtct ggagacctgc      900

tgccagaagc acaagctatt tcacccagac acctgcagct gtgaggacag atgccccttt      960

cataccagac catgtgcaag tggcaaaaca gcatgtgcaa agcattgccg ctttccaaag     1020

gagaaaaggg ctgcccaggg gccccacagc cgaaagaatc ct                        1062


<210>  12
<211>  1062
<212>  DNA
<213>  Homo sapiens

<400>  12
atgtacagag agtgggtagt ggtgaatgtt ttcatgatgt tgtacgtcca gctggtgcag       60

ggctccagta atgaacatgg accagtgaag cgatcatctc agtccacatt ggaacgatct      120

gaacagcaga tcagggctgc ttctagtttg gaggaactac ttcgaattac tcactctgag      180

gactggaagc tgtggagatg caggctgagg ctcaaaagtt ttaccagtat ggactctcgc      240

tcagcatccc atcggtccac taggtttgcg gcaactttct atgacattga aacactaaaa      300

gttatagatg aagaatggca aagaactcag tgcagcccta gagaaacgtg cgtggaggtg      360

gccagtgagc tggggaagag taccaacaca ttcttcaagc ccccttgtgt gaacgtgttc      420

cgatgtggtg gctgttgcaa tgaagagagc cttatctgta tgaacaccag cacctcgtac      480

atttccaaac agctctttga gatatcagtg cctttgacat cagtacctga attagtgcct      540

gttaaagttg ccaatcatac aggttgtaag tgcttgccaa cagccccccg ccatccatac      600

tcaattatca gaagatccat ccagatccct gaagaagatc gctgttccca ttccaagaaa      660

ctctgtccta ttgacatgct atgggatagc aacaaatgta aatgtgtttt gcaggaggaa      720

aatccacttg ctggaacaga agaccactct catctccagg aaccagctct ctgtgggcca      780

cacatgatgt ttgacgaaga tcgttgcgag tgtgtctgta aaacaccatg tcccaaagat      840

ctaatccagc accccaaaaa ctgcagttgc tttgagtgca aagaaagtct ggagacctgc      900

tgccagaagc acaagctatt tcacccagac acctgcagct gtgaggacag atgccccttt      960

cataccagac catgtgcaag tggcaaaaca gcatgtgcaa agcattgccg ctttccaaag     1020

gagaaaaggg ctgcccaggg gccccacagc cgaaagaatc ct                        1062


<210>  13
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Homo sapiens p15E protein

<400>  13

Lys Ser Pro Trp Phe Thr Thr Leu 
1               5               


