                         SEQUENCE LISTING

<110>  University of Kentucky Research Foundation
 
<120>  DIAGNOSIS OF DIABETES BY DETECTING AGGREGATED AMYLIN IN 
       ERYTHROCYTES

<130>  13177N/2182US

<150>  US 62/767,131
<151>  2018-11-14

<150>  US 62/883,992
<151>  2019-08-07

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  3125
<212>  PRT
<213>  Megathura crenulata

<400>  1

Leu Ser Val Arg Leu Leu Ile Val Val Leu Ala Leu Ala Asn Ala Glu 
1               5                   10                  15      


Asn Leu Val Arg Lys Ser Val Glu His Leu Thr Gln Glu Glu Thr Leu 
            20                  25                  30          


Asp Leu Gln Ala Ala Leu Arg Glu Leu Gln Met Asp Ser Ser Ser Ile 
        35                  40                  45              


Gly Phe Gln Lys Ile Ala Ala Ala His Gly Ala Pro Ala Ser Cys Val 
    50                  55                  60                  


His Lys Asp Thr Ser Ile Ala Cys Cys Ile His Gly Met Pro Thr Phe 
65                  70                  75                  80  


Pro His Trp His Arg Ala Tyr Val Val His Met Glu Arg Ala Leu Gln 
                85                  90                  95      


Thr Lys Arg Arg Thr Ser Gly Leu Pro Tyr Trp Asp Trp Thr Glu Pro 
            100                 105                 110         


Ile Thr Gln Leu Pro Ser Leu Ala Ala Asp Pro Val Tyr Ile Asp Ser 
        115                 120                 125             


Gln Gly Gly Lys Ala His Thr Asn Tyr Trp Tyr Arg Gly Asn Ile Asp 
    130                 135                 140                 


Phe Leu Asp Lys Lys Thr Asn Arg Ala Val Asp Asp Arg Leu Phe Glu 
145                 150                 155                 160 


Lys Val Lys Pro Gly Gln His Thr His Leu Met Glu Ser Val Leu Asp 
                165                 170                 175     


Ala Leu Glu Gln Asp Glu Phe Cys Lys Phe Glu Ile Gln Phe Glu Leu 
            180                 185                 190         


Ala His Asn Ala Ile His Tyr Leu Val Gly Gly Lys His Asp Tyr Ser 
        195                 200                 205             


Met Ala Asn Leu Glu Tyr Thr Ala Tyr Asp Pro Ile Phe Phe Leu His 
    210                 215                 220                 


His Ser Asn Val Asp Arg Ile Phe Ala Ile Trp Gln Arg Leu Gln Glu 
225                 230                 235                 240 


Leu Arg Asn Lys Asp Pro Lys Ala Met Asp Cys Ala Gln Glu Leu Leu 
                245                 250                 255     


His Gln Lys Met Glu Pro Phe Ser Trp Glu Asp Asn Asp Ile Pro Leu 
            260                 265                 270         


Thr Asn Glu His Ser Thr Pro Ala Asp Leu Phe Asp Tyr Cys Glu Leu 
        275                 280                 285             


His Tyr Asp Tyr Asp Thr Leu Asn Leu Asn Gly Met Thr Pro Glu Glu 
    290                 295                 300                 


Leu Lys Thr Tyr Leu Asp Glu Arg Ser Ser Arg Ala Arg Ala Phe Ala 
305                 310                 315                 320 


Ser Phe Arg Leu Lys Gly Phe Gly Gly Ser Ala Asn Val Phe Val Tyr 
                325                 330                 335     


Val Cys Ile Pro Asp Asp Asn Asp Arg Asn Asp Asp His Cys Glu Lys 
            340                 345                 350         


Ala Gly Asp Phe Phe Val Leu Gly Gly Pro Ser Glu Met Lys Trp Gln 
        355                 360                 365             


Phe Tyr Arg Pro Tyr Leu Phe Asp Leu Ser Asp Thr Val His Lys Met 
    370                 375                 380                 


Gly Met Lys Leu Asp Gly His Tyr Thr Val Lys Ala Glu Leu Phe Ser 
385                 390                 395                 400 


Val Asn Gly Thr Ala Leu Pro Asp Asp Leu Leu Pro His Pro Val Val 
                405                 410                 415     


Val His His Pro Glu Lys Gly Phe Thr Asp Pro Pro Val Lys His His 
            420                 425                 430         


Gln Ser Ala Asn Leu Leu Val Arg Lys Asn Ile Asn Asp Leu Thr Arg 
        435                 440                 445             


Glu Glu Val Leu Asn Leu Arg Glu Ala Phe His Lys Phe Gln Glu Asp 
    450                 455                 460                 


Arg Ser Val Asp Gly Tyr Gln Ala Thr Ala Glu Tyr His Gly Leu Pro 
465                 470                 475                 480 


Ala Arg Cys Pro Arg Pro Asp Ala Lys Asp Arg Tyr Ala Cys Cys Val 
                485                 490                 495     


His Gly Met Pro Ile Phe Pro His Trp His Arg Leu Phe Val Thr Gln 
            500                 505                 510         


Val Glu Asp Ala Leu Val Gly Arg Gly Ala Thr Ile Gly Ile Pro Tyr 
        515                 520                 525             


Trp Asp Trp Thr Glu Pro Met Thr His Ile Pro Gly Leu Ala Gly Asn 
    530                 535                 540                 


Lys Thr Tyr Val Asp Ser His Gly Ala Ser His Thr Asn Pro Phe His 
545                 550                 555                 560 


Ser Ser Val Ile Ala Phe Glu Glu Asn Ala Pro His Thr Lys Arg Gln 
                565                 570                 575     


Ile Asp Gln Arg Leu Phe Lys Pro Ala Thr Phe Gly His His Thr Asp 
            580                 585                 590         


Leu Phe Asn Gln Ile Leu Tyr Ala Phe Glu Gln Glu Asp Tyr Cys Asp 
        595                 600                 605             


Phe Glu Val Gln Phe Glu Ile Thr His Asn Thr Ile His Ala Trp Thr 
    610                 615                 620                 


Gly Gly Ser Glu His Phe Ser Met Ser Ser Leu His Tyr Thr Ala Phe 
625                 630                 635                 640 


Asp Pro Leu Phe Tyr Phe His His Ser Asn Val Asp Arg Leu Trp Ala 
                645                 650                 655     


Val Trp Gln Ala Leu Gln Met Arg Arg His Lys Pro Tyr Arg Ala His 
            660                 665                 670         


Cys Ala Ile Ser Leu Glu His Met His Leu Lys Pro Phe Ala Phe Ser 
        675                 680                 685             


Ser Pro Leu Asn Asn Asn Glu Lys Thr His Ala Asn Ala Met Pro Asn 
    690                 695                 700                 


Lys Ile Tyr Asp Tyr Glu Asn Val Leu His Tyr Thr Tyr Glu Asp Leu 
705                 710                 715                 720 


Thr Phe Gly Gly Ile Ser Leu Glu Asn Ile Glu Lys Met Ile His Glu 
                725                 730                 735     


Asn Gln Gln Glu Asp Arg Ile Tyr Ala Gly Phe Leu Leu Ala Gly Ile 
            740                 745                 750         


Arg Thr Ser Ala Asn Val Asp Ile Phe Ile Lys Thr Thr Asp Ser Val 
        755                 760                 765             


Gln His Lys Ala Gly Thr Phe Ala Val Leu Gly Gly Ser Lys Glu Met 
    770                 775                 780                 


Lys Trp Gly Phe Asp Arg Val Phe Lys Phe Asp Ile Thr His Val Leu 
785                 790                 795                 800 


Lys Asp Leu Asp Leu Thr Ala Asp Gly Asp Phe Glu Val Thr Val Asp 
                805                 810                 815     


Ile Thr Glu Val Asp Gly Thr Lys Leu Ala Ser Ser Leu Ile Pro His 
            820                 825                 830         


Ala Ser Val Ile Arg Glu His Ala Arg Val Lys Phe Asp Lys Val Pro 
        835                 840                 845             


Arg Ser Arg Leu Ile Arg Lys Asn Val Asp Arg Leu Ser Pro Glu Glu 
    850                 855                 860                 


Met Asn Glu Leu Arg Lys Ala Leu Ala Leu Leu Lys Glu Asp Lys Ser 
865                 870                 875                 880 


Ala Gly Gly Phe Gln Gln Leu Gly Ala Phe His Gly Glu Pro Lys Trp 
                885                 890                 895     


Cys Pro Ser Pro Glu Ala Ser Lys Lys Phe Ala Cys Cys Val His Gly 
            900                 905                 910         


Met Ser Val Phe Pro His Trp His Arg Leu Leu Thr Val Gln Ser Glu 
        915                 920                 925             


Asn Ala Leu Arg Arg His Gly Tyr Asp Gly Ala Leu Pro Tyr Trp Asp 
    930                 935                 940                 


Trp Thr Ser Pro Leu Asn His Leu Pro Glu Leu Ala Asp His Glu Lys 
945                 950                 955                 960 


Tyr Val Asp Pro Glu Asp Gly Val Glu Lys His Asn Pro Trp Phe Asp 
                965                 970                 975     


Gly His Ile Asp Thr Val Asp Lys Thr Thr Thr Arg Ser Val Gln Asn 
            980                 985                 990         


Lys Leu Phe Glu Gln Pro Glu Phe  Gly His Tyr Thr Ser  Ile Ala Lys 
        995                 1000                 1005             


Gln Val  Leu Leu Ala Leu Glu  Gln Asp Asn Phe Cys  Asp Phe Glu 
    1010                 1015                 1020             


Ile Gln  Tyr Glu Ile Ala His  Asn Tyr Ile His Ala  Leu Val Gly 
    1025                 1030                 1035             


Gly Ala  Gln Pro Tyr Gly Met  Ala Ser Leu Arg Tyr  Thr Ala Phe 
    1040                 1045                 1050             


Asp Pro  Leu Phe Tyr Leu His  His Ser Asn Thr Asp  Arg Ile Trp 
    1055                 1060                 1065             


Ala Ile  Trp Gln Ala Leu Gln  Lys Tyr Arg Gly Lys  Pro Tyr Asn 
    1070                 1075                 1080             


Val Ala  Asn Cys Ala Val Thr  Ser Met Arg Glu Pro  Leu Gln Pro 
    1085                 1090                 1095             


Phe Gly  Leu Ser Ala Asn Ile  Asn Thr Asp His Val  Thr Lys Glu 
    1100                 1105                 1110             


His Ser  Val Pro Phe Asn Val  Phe Asp Tyr Lys Thr  Asn Phe Asn 
    1115                 1120                 1125             


Tyr Glu  Tyr Asp Thr Leu Glu  Phe Asn Gly Leu Ser  Ile Ser Gln 
    1130                 1135                 1140             


Leu Asn  Lys Lys Leu Glu Ala  Ile Lys Ser Gln Asp  Arg Phe Phe 
    1145                 1150                 1155             


Ala Gly  Phe Leu Leu Ser Gly  Phe Lys Lys Ser Ser  Leu Val Lys 
    1160                 1165                 1170             


Phe Asn  Ile Cys Thr Asp Ser  Ser Asn Cys His Pro  Ala Gly Glu 
    1175                 1180                 1185             


Phe Tyr  Leu Leu Gly Asp Glu  Asn Glu Met Pro Trp  Ala Tyr Asp 
    1190                 1195                 1200             


Arg Val  Phe Lys Tyr Asp Ile  Thr Glu Lys Leu His  Asp Leu Lys 
    1205                 1210                 1215             


Leu His  Ala Glu Asp His Phe  Tyr Ile Asp Tyr Glu  Val Phe Asp 
    1220                 1225                 1230             


Leu Lys  Pro Ala Ser Leu Gly  Lys Asp Leu Phe Lys  Gln Pro Ser 
    1235                 1240                 1245             


Val Ile  His Glu Pro Arg Ile  Gly His His Glu Gly  Glu Val Tyr 
    1250                 1255                 1260             


Gln Ala  Glu Val Thr Ser Ala  Asn Arg Ile Arg Lys  Asn Ile Glu 
    1265                 1270                 1275             


Asn Leu  Ser Leu Gly Glu Leu  Glu Ser Leu Arg Ala  Ala Phe Leu 
    1280                 1285                 1290             


Glu Ile  Glu Asn Asp Gly Thr  Tyr Glu Ser Ile Ala  Lys Phe His 
    1295                 1300                 1305             


Gly Ser  Pro Gly Leu Cys Gln  Leu Asn Gly Asn Pro  Ile Ser Cys 
    1310                 1315                 1320             


Cys Val  His Gly Met Pro Thr  Phe Pro His Trp His  Arg Leu Tyr 
    1325                 1330                 1335             


Val Val  Val Val Glu Asn Ala  Leu Leu Lys Lys Gly  Ser Ser Val 
    1340                 1345                 1350             


Ala Val  Pro Tyr Trp Asp Trp  Thr Lys Arg Ile Glu  His Leu Pro 
    1355                 1360                 1365             


His Leu  Ile Ser Asp Ala Thr  Tyr Tyr Asn Ser Arg  Gln His His 
    1370                 1375                 1380             


Tyr Glu  Thr Asn Pro Phe His  His Gly Lys Ile Thr  His Glu Asn 
    1385                 1390                 1395             


Glu Ile  Thr Thr Arg Asp Pro  Lys Asp Ser Leu Phe  His Ser Asp 
    1400                 1405                 1410             


Tyr Phe  Tyr Glu Gln Val Leu  Tyr Ala Leu Glu Gln  Asp Asn Phe 
    1415                 1420                 1425             


Cys Asp  Phe Glu Ile Gln Leu  Glu Ile Leu His Asn  Ala Leu His 
    1430                 1435                 1440             


Ser Leu  Leu Gly Gly Lys Gly  Lys Tyr Ser Met Ser  Asn Leu Asp 
    1445                 1450                 1455             


Tyr Ala  Ala Phe Asp Pro Val  Phe Phe Leu His His  Ala Thr Thr 
    1460                 1465                 1470             


Asp Arg  Ile Trp Ala Ile Trp  Gln Asp Leu Gln Arg  Phe Arg Lys 
    1475                 1480                 1485             


Arg Pro  Tyr Arg Glu Ala Asn  Cys Ala Ile Gln Leu  Met His Thr 
    1490                 1495                 1500             


Pro Leu  Gln Pro Phe Asp Lys  Ser Asp Asn Asn Asp  Glu Ala Thr 
    1505                 1510                 1515             


Lys Thr  His Ala Thr Pro His  Asp Gly Phe Glu Tyr  Gln Asn Ser 
    1520                 1525                 1530             


Phe Gly  Tyr Ala Tyr Asp Asn  Leu Glu Leu Asn His  Tyr Ser Ile 
    1535                 1540                 1545             


Pro Gln  Leu Asp His Met Leu  Gln Glu Arg Lys Arg  His Asp Arg 
    1550                 1555                 1560             


Val Phe  Ala Gly Phe Leu Leu  His Asn Ile Gly Thr  Ser Ala Asp 
    1565                 1570                 1575             


Gly His  Val Phe Val Cys Leu  Pro Thr Gly Glu His  Thr Lys Asp 
    1580                 1585                 1590             


Cys Ser  His Glu Ala Gly Met  Phe Ser Ile Leu Gly  Gly Gln Thr 
    1595                 1600                 1605             


Glu Met  Ser Phe Val Phe Asp  Arg Leu Tyr Lys Leu  Asp Ile Thr 
    1610                 1615                 1620             


Lys Ala  Leu Lys Lys Asn Gly  Val His Leu Gln Gly  Asp Phe Asp 
    1625                 1630                 1635             


Leu Glu  Ile Glu Ile Thr Ala  Val Asn Gly Ser His  Leu Asp Ser 
    1640                 1645                 1650             


His Val  Ile His Ser Pro Thr  Ile Leu Phe Glu Ala  Gly Thr Asp 
    1655                 1660                 1665             


Ser Ala  His Thr Asp Asp Gly  His Thr Glu Pro Val  Met Ile Arg 
    1670                 1675                 1680             


Lys Asp  Ile Thr Gln Leu Asp  Lys Arg Gln Gln Leu  Ser Leu Val 
    1685                 1690                 1695             


Lys Ala  Leu Glu Ser Met Lys  Ala Asp His Ser Ser  Asp Gly Phe 
    1700                 1705                 1710             


Gln Ala  Ile Ala Ser Phe His  Ala Leu Pro Pro Leu  Cys Pro Ser 
    1715                 1720                 1725             


Pro Ala  Ala Ser Lys Arg Phe  Ala Cys Cys Val His  Gly Met Ala 
    1730                 1735                 1740             


Thr Phe  Pro Gln Trp His Arg  Leu Tyr Thr Val Gln  Phe Gln Asp 
    1745                 1750                 1755             


Ser Leu  Arg Lys His Gly Ala  Val Val Gly Leu Pro  Tyr Trp Asp 
    1760                 1765                 1770             


Trp Thr  Leu Pro Arg Ser Glu  Leu Pro Glu Leu Leu  Thr Val Ser 
    1775                 1780                 1785             


Thr Ile  His Asp Pro Glu Thr  Gly Arg Asp Ile Pro  Asn Pro Phe 
    1790                 1795                 1800             


Ile Gly  Ser Lys Ile Glu Phe  Glu Gly Glu Asn Val  His Thr Lys 
    1805                 1810                 1815             


Arg Asp  Ile Asn Arg Asp Arg  Leu Phe Gln Gly Ser  Thr Lys Thr 
    1820                 1825                 1830             


His His  Asn Trp Phe Ile Glu  Gln Ala Leu Leu Ala  Leu Glu Gln 
    1835                 1840                 1845             


Thr Asn  Tyr Cys Asp Phe Glu  Val Gln Phe Glu Ile  Met His Asn 
    1850                 1855                 1860             


Gly Val  His Thr Trp Val Gly  Gly Lys Glu Pro Tyr  Gly Ile Gly 
    1865                 1870                 1875             


His Leu  His Tyr Ala Ser Tyr  Asp Pro Leu Phe Tyr  Ile His His 
    1880                 1885                 1890             


Ser Gln  Thr Asp Arg Ile Trp  Ala Ile Trp Gln Ser  Leu Gln Arg 
    1895                 1900                 1905             


Phe Arg  Gly Leu Ser Gly Ser  Glu Ala Asn Cys Ala  Val Asn Leu 
    1910                 1915                 1920             


Met Lys  Thr Pro Leu Lys Pro  Phe Ser Phe Gly Ala  Pro Tyr Asn 
    1925                 1930                 1935             


Leu Asn  Asp His Thr His Asp  Phe Ser Lys Pro Glu  Asp Thr Phe 
    1940                 1945                 1950             


Asp Tyr  Gln Lys Phe Gly Tyr  Ile Tyr Asp Thr Leu  Glu Phe Ala 
    1955                 1960                 1965             


Gly Trp  Ser Ile Arg Gly Ile  Asp His Ile Val Arg  Asn Arg Gln 
    1970                 1975                 1980             


Glu His  Ser Arg Val Phe Ala  Gly Phe Leu Leu Glu  Gly Phe Gly 
    1985                 1990                 1995             


Thr Ser  Ala Thr Val Asp Phe  Gln Val Cys Arg Thr  Ala Gly Asp 
    2000                 2005                 2010             


Cys Glu  Asp Ala Gly Tyr Phe  Thr Val Leu Gly Gly  Glu Lys Glu 
    2015                 2020                 2025             


Met Pro  Trp Ala Phe Asp Arg  Leu Tyr Lys Tyr Asp  Ile Thr Glu 
    2030                 2035                 2040             


Thr Leu  Asp Lys Met Asn Leu  Arg His Asp Glu Ile  Phe Gln Ile 
    2045                 2050                 2055             


Glu Val  Thr Ile Thr Ser Tyr  Asp Gly Thr Val Leu  Asp Ser Gly 
    2060                 2065                 2070             


Leu Ile  Pro Thr Pro Ser Ile  Ile Tyr Asp Pro Ala  His His Asp 
    2075                 2080                 2085             


Ile Ser  Ser His His Leu Ser  Leu Asn Lys Val Arg  His Asp Leu 
    2090                 2095                 2100             


Ser Thr  Leu Ser Glu Arg Asp  Ile Gly Ser Leu Lys  Tyr Ala Leu 
    2105                 2110                 2115             


Ser Ser  Leu Gln Ala Asp Thr  Ser Ala Asp Gly Phe  Ala Ala Ile 
    2120                 2125                 2130             


Ala Ser  Phe His Gly Leu Pro  Ala Lys Cys Asn Asp  Ser His Asn 
    2135                 2140                 2145             


Asn Glu  Val Ala Cys Cys Ile  His Gly Met Pro Thr  Phe Pro His 
    2150                 2155                 2160             


Trp His  Arg Leu Tyr Thr Leu  Gln Phe Glu Gln Ala  Leu Arg Arg 
    2165                 2170                 2175             


His Gly  Ser Ser Val Ala Val  Pro Tyr Trp Asp Trp  Thr Lys Pro 
    2180                 2185                 2190             


Ile His  Asn Ile Pro His Leu  Phe Thr Asp Lys Glu  Tyr Tyr Asp 
    2195                 2200                 2205             


Val Trp  Arg Asn Lys Val Met  Pro Asn Pro Phe Ala  Arg Gly Tyr 
    2210                 2215                 2220             


Val Pro  Ser His Asp Thr Tyr  Thr Val Arg Asp Val  Gln Glu Gly 
    2225                 2230                 2235             


Leu Phe  His Leu Thr Ser Thr  Gly Glu His Ser Ala  Leu Leu Asn 
    2240                 2245                 2250             


Gln Ala  Leu Leu Ala Leu Glu  Gln His Asp Tyr Cys  Asp Phe Ala 
    2255                 2260                 2265             


Val Gln  Phe Glu Val Met His  Asn Thr Ile His Tyr  Leu Val Gly 
    2270                 2275                 2280             


Gly Pro  Gln Val Tyr Ser Leu  Ser Ser Leu His Tyr  Ala Ser Tyr 
    2285                 2290                 2295             


Asp Pro  Ile Phe Phe Ile His  His Ser Phe Val Asp  Lys Val Trp 
    2300                 2305                 2310             


Ala Val  Trp Gln Ala Leu Gln  Glu Lys Arg Gly Leu  Pro Ser Asp 
    2315                 2320                 2325             


Arg Ala  Asp Cys Ala Val Ser  Leu Met Thr Gln Asn  Met Arg Pro 
    2330                 2335                 2340             


Phe His  Tyr Glu Ile Asn His  Asn Gln Phe Thr Lys  Lys His Ala 
    2345                 2350                 2355             


Val Pro  Asn Asp Val Phe Lys  Tyr Glu Leu Leu Gly  Tyr Arg Tyr 
    2360                 2365                 2370             


Asp Asn  Leu Glu Ile Gly Gly  Met Asn Leu His Glu  Ile Glu Lys 
    2375                 2380                 2385             


Glu Ile  Lys Asp Lys Gln His  His Val Arg Val Phe  Ala Gly Phe 
    2390                 2395                 2400             


Leu Leu  His Gly Ile Arg Thr  Ser Ala Asp Val Gln  Phe Gln Ile 
    2405                 2410                 2415             


Cys Lys  Thr Ser Glu Asp Cys  His His Gly Gly Gln  Ile Phe Val 
    2420                 2425                 2430             


Leu Gly  Gly Thr Lys Glu Met  Ala Trp Ala Tyr Asn  Arg Leu Phe 
    2435                 2440                 2445             


Lys Tyr  Asp Ile Thr His Ala  Leu His Asp Ala His  Ile Thr Pro 
    2450                 2455                 2460             


Glu Asp  Val Phe His Pro Ser  Glu Pro Phe Phe Ile  Lys Val Ser 
    2465                 2470                 2475             


Val Thr  Ala Val Asn Gly Thr  Val Leu Pro Ala Ser  Ile Leu His 
    2480                 2485                 2490             


Ala Pro  Thr Ile Ile Tyr Glu  Pro Gly Leu Asp His  His Glu Asp 
    2495                 2500                 2505             


His His  Ser Ser Ser Met Ala  Gly His Gly Val Arg  Lys Glu Ile 
    2510                 2515                 2520             


Asn Thr  Leu Thr Thr Ala Glu  Val Asp Asn Leu Lys  Asp Ala Met 
    2525                 2530                 2535             


Arg Ala  Val Met Ala Asp His  Gly Pro Asn Gly Tyr  Gln Ala Ile 
    2540                 2545                 2550             


Ala Ala  Phe His Gly Asn Pro  Pro Met Cys Pro Met  Pro Asp Gly 
    2555                 2560                 2565             


Lys Asn  Tyr Ser Cys Cys Thr  His Gly Met Ala Thr  Phe Pro His 
    2570                 2575                 2580             


Trp His  Arg Leu Tyr Thr Lys  Gln Met Glu Asp Ala  Leu Thr Ala 
    2585                 2590                 2595             


His Gly  Ala Arg Val Gly Leu  Pro Tyr Trp Asp Gly  Thr Thr Ala 
    2600                 2605                 2610             


Phe Thr  Ala Leu Pro Thr Phe  Val Thr Asp Glu Glu  Asp Asn Pro 
    2615                 2620                 2625             


Phe His  His Gly His Ile Asp  Tyr Leu Gly Val Asp  Thr Thr Arg 
    2630                 2635                 2640             


Ser Pro  Arg Asp Lys Leu Phe  Asn Asp Pro Glu Arg  Gly Ser Glu 
    2645                 2650                 2655             


Ser Phe  Phe Tyr Arg Gln Val  Leu Leu Ala Leu Glu  Gln Thr Asp 
    2660                 2665                 2670             


Phe Cys  Gln Phe Glu Val Gln  Phe Glu Ile Thr His  Asn Ala Ile 
    2675                 2680                 2685             


His Ser  Trp Thr Gly Gly Leu  Thr Pro Tyr Gly Met  Ser Thr Leu 
    2690                 2695                 2700             


Glu Tyr  Thr Thr Tyr Asp Pro  Leu Phe Trp Leu His  His Ala Asn 
    2705                 2710                 2715             


Thr Asp  Arg Ile Trp Ala Ile  Trp Gln Ala Leu Gln  Glu Tyr Arg 
    2720                 2725                 2730             


Gly Leu  Pro Tyr Asp His Ala  Asn Cys Glu Ile Gln  Ala Met Lys 
    2735                 2740                 2745             


Arg Pro  Leu Arg Pro Phe Ser  Asp Pro Ile Asn His  Asn Ala Phe 
    2750                 2755                 2760             


Thr His  Ser Asn Ala Lys Pro  Thr Asp Val Phe Glu  Tyr Ser Arg 
    2765                 2770                 2775             


Phe Asn  Phe Gln Tyr Asp Asn  Leu Arg Phe His Gly  Met Thr Ile 
    2780                 2785                 2790             


Lys Lys  Leu Glu His Glu Leu  Glu Lys Gln Lys Glu  Glu Asp Arg 
    2795                 2800                 2805             


Thr Phe  Ala Ala Phe Leu Leu  His Gly Ile Lys Lys  Ser Ala Asp 
    2810                 2815                 2820             


Val Ser  Phe Asp Val Cys Asn  His Asp Gly Glu Cys  His Phe Ala 
    2825                 2830                 2835             


Gly Thr  Phe Ala Ile Leu Gly  Gly Glu His Glu Met  Pro Trp Ser 
    2840                 2845                 2850             


Phe Asp  Arg Leu Phe Arg Tyr  Asp Ile Thr Gln Val  Leu Lys Gln 
    2855                 2860                 2865             


Met His  Leu Glu Tyr Asp Ser  Asp Phe Thr Phe His  Met Arg Ile 
    2870                 2875                 2880             


Ile Asp  Thr Ser Gly Lys Gln  Leu Pro Ser Asp Leu  Ile Lys Met 
    2885                 2890                 2895             


Pro Thr  Val Glu His Ser Pro  Gly Gly Lys His His  Glu Lys His 
    2900                 2905                 2910             


His Glu  Asp His His Glu Asp  Ile Leu Val Arg Lys  Asn Ile His 
    2915                 2920                 2925             


Ser Leu  Ser His His Glu Ala  Glu Glu Leu Arg Asp  Ala Leu Tyr 
    2930                 2935                 2940             


Lys Leu  Gln Asn Asp Glu Ser  His Gly Gly Tyr Glu  His Ile Ala 
    2945                 2950                 2955             


Gly Phe  His Gly Tyr Pro Asn  Leu Cys Pro Glu Lys  Gly Asp Glu 
    2960                 2965                 2970             


Lys Tyr  Pro Cys Cys Val His  Gly Met Ser Ile Phe  Pro His Trp 
    2975                 2980                 2985             


His Arg  Leu His Thr Ile Gln  Phe Glu Arg Ala Leu  Lys Lys His 
    2990                 2995                 3000             


Gly Ser  His Leu Gly Ile Pro  Tyr Trp Asp Trp Thr  Gln Thr Ile 
    3005                 3010                 3015             


Ser Ser  Leu Pro Thr Phe Phe  Ala Asp Ser Gly Asn  Asn Asn Pro 
    3020                 3025                 3030             


Phe Phe  Lys Tyr His Ile Arg  Ser Ile Asn Gln Asp  Thr Val Arg 
    3035                 3040                 3045             


Asp Val  Asn Glu Ala Ile Phe  Gln Gln Thr Lys Phe  Gly Glu Phe 
    3050                 3055                 3060             


Ser Ser  Ile Phe Tyr Leu Ala  Leu Gln Ala Leu Glu  Glu Asp Asn 
    3065                 3070                 3075             


Tyr Cys  Asp Phe Glu Val Gln  Tyr Glu Ile Leu His  Asn Glu Val 
    3080                 3085                 3090             


His Ala  Leu Ile Gly Gly Ala  Glu Lys Tyr Ser Met  Ser Thr Leu 
    3095                 3100                 3105             


Glu Tyr  Ser Ala Phe Asp Pro  Tyr Phe Met Ile His  His Ala Ser 
    3110                 3115                 3120             


Leu Asp  
    3125 


<210>  2
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amylin Peptide

<400>  2

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amylin C

<400>  3

Cys Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val Gly Ser Asn 
1               5                   10                  15      


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amylin N

<400>  4

Cys Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe 
1               5                   10                  15      


Leu Val His Ser Ser 
            20      


<210>  5
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amyloid beta

<400>  5

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abeta N

<400>  6

Cys Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln 
1               5                   10                  15      


<210>  7
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abeta C

<400>  7

Cys Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala 
1               5                   10                  15      


Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala 
            20                  25              


