                         SEQUENCE LISTING

<110>  Broad Institute, Inc.
 
<120>  ARYL HYDROCARBON RECEPTOR (AHR) ACTIVATOR COMPOUNDS AS CANCER 
       THERAPEUTICS

<130>  52199-539001WO

<150>  62/767,474
<151>  2018-11-14

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  3396
<212>  DNA
<213>  Homo sapiens

<400>  1
gggcttcctc ttcgcccggg tggcgttggg cccgcgcggg cgctcgggtg actgcagctg       60

ctcagctccc ctcccccgcc ccgcgccgcg cggccgcccg tcgcttcgca cagggctgga      120

tggttgtatt gggcagggtg gctccaggat gttaggaact gtgaagatgg aagggcatga      180

aaccagcgac tggaacagct actacgcaga cacgcaggag gcctactcct ccgtcccggt      240

cagcaacatg aactcaggcc tgggctccat gaactccatg aacacctaca tgaccatgaa      300

caccatgact acgagcggca acatgacccc ggcgtccttc aacatgtcct atgccaaccc      360

gggcctaggg gccggcctga gtcccggcgc agtagccggc atgccggggg gctcggcggg      420

cgccatgaac agcatgactg cggccggcgt gacggccatg ggtacggcgc tgagcccgag      480

cggcatgggc gccatgggtg cgcagcaggc ggcctccatg aatggcctgg gcccctacgc      540

ggccgccatg aacccgtgca tgagccccat ggcgtacgcg ccgtccaacc tgggccgcag      600

ccgcgcgggc ggcggcggcg acgccaagac gttcaagcgc agctacccgc acgccaagcc      660

gccctactcg tacatctcgc tcatcaccat ggccatccag caggcgccca gcaagatgct      720

cacgctgagc gagatctacc agtggatcat ggacctcttc ccctattacc ggcagaacca      780

gcagcgctgg cagaactcca tccgccactc gctgtccttc aatgactgct tcgtcaaggt      840

ggcacgctcc ccggacaagc cgggcaaggg ctcctactgg acgctgcacc cggactccgg      900

caacatgttc gagaacggct gctacttgcg ccgccagaag cgcttcaagt gcgagaagca      960

gccgggggcc ggcggcgggg gcgggagcgg aagcgggggc agcggcgcca agggcggccc     1020

tgagagccgc aaggacccct ctggcgcctc taaccccagc gccgactcgc ccctccatcg     1080

gggtgtgcac gggaagaccg gccagctaga gggcgcgccg gcccccgggc ccgccgccag     1140

cccccagact ctggaccaca gtggggcgac ggcgacaggg ggcgcctcgg agttgaagac     1200

tccagcctcc tcaactgcgc cccccataag ctccgggccc ggggcgctgg cctctgtgcc     1260

cgcctctcac ccggcacacg gcttggcacc ccacgagtcc cagctgcacc tgaaagggga     1320

cccccactac tccttcaacc acccgttctc catcaacaac ctcatgtcct cctcggagca     1380

gcagcataag ctggacttca aggcatacga acaggcactg caatactcgc cttacggctc     1440

tacgttgccc gccagcctgc ctctaggcag cgcctcggtg accaccagga gccccatcga     1500

gccctcagcc ctggagccgg cgtactacca aggtgtgtat tccagacccg tcctaaacac     1560

ttcctagctc ccgggactgg ggggtttgtc tggcatagcc atgctggtag caagagagaa     1620

aaaatcaaca gcaaacaaaa ccacacaaac caaaccgtca acagcataat aaaatcccaa     1680

caactatttt tatttcattt ttcatgcaca acctttcccc cagtgcaaaa gactgttact     1740

ttattattgt attcaaaatt cattgtgtat attactacaa agacaacccc aaaccaattt     1800

ttttcctgcg aagtttaatg atccacaagt gtatatatga aattctcctc cttccttgcc     1860

cccctctctt tcttccctct ttcccctcca gacattctag tttgtggagg gttatttaaa     1920

aaaacaaaaa aggaagatgg tcaagtttgt aaaatatttg tttgtgcttt ttccccctcc     1980

ttacctgacc ccctacgagt ttacaggtct gtggcaatac tcttaaccat aagaattgaa     2040

atggtgaaga aacaagtata cactagaggc tcttaaaagt attgaaagac aatactgctg     2100

ttatatagca agacataaac agattataaa catcagagcc atttgcttct cagtttacat     2160

ttctgataca tgcagatagc agatgtcttt aaatgaaata catgtatatt gtgtatggac     2220

ttaattatgc acatgctcag atgtgtagac atcctccgta tatttacata acatatagag     2280

gtaatagata ggtgatatac atgatacatt ctcaagagtt gcttgaccga aagttacaag     2340

gaccccaacc cctttgtcct ctctacccac agatggccct gggaatcaat tcctcaggaa     2400

ttgccctcaa gaactctgct tcttgctttg cagagtgcca tggtcatgtc attctgaggt     2460

cacataacac ataaaattag tttctatgag tgtataccat ttaaagaatt tttttttcag     2520

taaaagggaa tattacaatg ttggaggaga gataagttat agggagctgg atttcaaaac     2580

gtggtccaag attcaaaaat cctattgata gtggccattt taatcattgc catcgtgtgc     2640

ttgtttcatc cagtgttatg cactttccac agttggacat ggtgttagta tagccagacg     2700

ggtttcatta ttatttctct ttgctttctc aatgttaatt tattgcatgg tttattcttt     2760

ttctttacag ctgaaattgc tttaaatgat ggttaaaatt acaaattaaa ttgttaattt     2820

ttatcaatgt gattgtaatt aaaaatattt tgatttaaat aacaaaaata ataccagatt     2880

ttaagccgtg gaaaatgttc ttgatcattt gcagttaagg actttaaata aatcaaatgt     2940

taacaaaaga gcatttctgt tatttttttt cacttaacta aatccgaagt gaatatttct     3000

gaatacgata tttttcaaat tctagaactg aatataaatg acaaaaatga aaataaaatt     3060

gttttgtctg ttgttataat gaatgtgtag ctagtaaaaa ggagtgaaag aaattcaagt     3120

aaagtgtata agttgattta atattccaag agttgagatt tttaagattc tttattccca     3180

gtgatgttta cttcattttt tttttttttt ttgacaccgg cttaagcctt ctgtgtttcc     3240

tttgagcctt ttcactacaa aatcaaatat taatttaact acctttcctc cttccccaat     3300

gtatcacttt tctttatctg agaattcttc caatgaaaat aaaatatcag ctgtggctga     3360

tagaattaag ttgtgtccaa aaaaaaaaaa aaaaaa                               3396


<210>  2
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Gly Thr Val Lys Met Glu Gly His Glu Thr Ser Asp Trp Asn 
1               5                   10                  15      


Ser Tyr Tyr Ala Asp Thr Gln Glu Ala Tyr Ser Ser Val Pro Val Ser 
            20                  25                  30          


Asn Met Asn Ser Gly Leu Gly Ser Met Asn Ser Met Asn Thr Tyr Met 
        35                  40                  45              


Thr Met Asn Thr Met Thr Thr Ser Gly Asn Met Thr Pro Ala Ser Phe 
    50                  55                  60                  


Asn Met Ser Tyr Ala Asn Pro Gly Leu Gly Ala Gly Leu Ser Pro Gly 
65                  70                  75                  80  


Ala Val Ala Gly Met Pro Gly Gly Ser Ala Gly Ala Met Asn Ser Met 
                85                  90                  95      


Thr Ala Ala Gly Val Thr Ala Met Gly Thr Ala Leu Ser Pro Ser Gly 
            100                 105                 110         


Met Gly Ala Met Gly Ala Gln Gln Ala Ala Ser Met Asn Gly Leu Gly 
        115                 120                 125             


Pro Tyr Ala Ala Ala Met Asn Pro Cys Met Ser Pro Met Ala Tyr Ala 
    130                 135                 140                 


Pro Ser Asn Leu Gly Arg Ser Arg Ala Gly Gly Gly Gly Asp Ala Lys 
145                 150                 155                 160 


Thr Phe Lys Arg Ser Tyr Pro His Ala Lys Pro Pro Tyr Ser Tyr Ile 
                165                 170                 175     


Ser Leu Ile Thr Met Ala Ile Gln Gln Ala Pro Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg 
        195                 200                 205             


Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe 
    210                 215                 220                 


Asn Asp Cys Phe Val Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys 
225                 230                 235                 240 


Gly Ser Tyr Trp Thr Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn 
                245                 250                 255     


Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Pro 
            260                 265                 270         


Gly Ala Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Ala Lys 
        275                 280                 285             


Gly Gly Pro Glu Ser Arg Lys Asp Pro Ser Gly Ala Ser Asn Pro Ser 
    290                 295                 300                 


Ala Asp Ser Pro Leu His Arg Gly Val His Gly Lys Thr Gly Gln Leu 
305                 310                 315                 320 


Glu Gly Ala Pro Ala Pro Gly Pro Ala Ala Ser Pro Gln Thr Leu Asp 
                325                 330                 335     


His Ser Gly Ala Thr Ala Thr Gly Gly Ala Ser Glu Leu Lys Thr Pro 
            340                 345                 350         


Ala Ser Ser Thr Ala Pro Pro Ile Ser Ser Gly Pro Gly Ala Leu Ala 
        355                 360                 365             


Ser Val Pro Ala Ser His Pro Ala His Gly Leu Ala Pro His Glu Ser 
    370                 375                 380                 


Gln Leu His Leu Lys Gly Asp Pro His Tyr Ser Phe Asn His Pro Phe 
385                 390                 395                 400 


Ser Ile Asn Asn Leu Met Ser Ser Ser Glu Gln Gln His Lys Leu Asp 
                405                 410                 415     


Phe Lys Ala Tyr Glu Gln Ala Leu Gln Tyr Ser Pro Tyr Gly Ser Thr 
            420                 425                 430         


Leu Pro Ala Ser Leu Pro Leu Gly Ser Ala Ser Val Thr Thr Arg Ser 
        435                 440                 445             


Pro Ile Glu Pro Ser Ala Leu Glu Pro Ala Tyr Tyr Gln Gly Val Tyr 
    450                 455                 460                 


Ser Arg Pro Val Leu Asn Thr Ser 
465                 470         


<210>  3
<211>  996
<212>  DNA
<213>  Homo sapiens

<400>  3
aatcacttgg ggaaaggaag gttcgtttct gagttagcaa caagtaaatg cagcactagt       60

gggtgggatt gaggtatgcc ctggtgcata aatagagact cagctgtgct ggcacactca      120

gaagcttgga ccgcatccta gccgccgact cacacaaggc aggtgggtga ggaaatccag      180

agttgccatg gagaaaattc cagtgtcagc attcttgctc cttgtggccc tctcctacac      240

tctggccaga gataccacag tcaaacctgg agccaaaaag gacacaaagg actctcgacc      300

caaactgccc cagaccctct ccagaggttg gggtgaccaa ctcatctgga ctcagacata      360

tgaagaagct ctatataaat ccaagacaag caacaaaccc ttgatgatta ttcatcactt      420

ggatgagtgc ccacacagtc aagctttaaa gaaagtgttt gctgaaaata aagaaatcca      480

gaaattggca gagcagtttg tcctcctcaa tctggtttat gaaacaactg acaaacacct      540

ttctcctgat ggccagtatg tccccaggat tatgtttgtt gacccatctc tgacagttag      600

agccgatatc actggaagat attcaaatcg tctctatgct tacgaacctg cagatacagc      660

tctgttgctt gacaacatga agaaagctct caagttgctg aagactgaat tgtaaagaaa      720

aaaaatctcc aagcccttct gtctgtcagg ccttgagact tgaaaccaga agaagtgtga      780

gaagactggc tagtgtggaa gcatagtgaa cacactgatt aggttatggt ttaatgttac      840

aacaactatt ttttaagaaa aacaagtttt agaaatttgg tttcaagtgt acatgtgtga      900

aaacaatatt gtatactacc atagtgagcc atgattttct aaaaaaaaaa ataaatgttt      960

tgggggtgtt ctgttttctc caaaaaaaaa aaaaaa                                996


<210>  4
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Thr Leu Ala Arg Asp Thr Thr Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Thr Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Thr Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Met Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Thr Ala Leu Leu 
145                 150                 155                 160 


Leu Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Thr Glu Leu 
                165                 170                 175 


<210>  5
<211>  767
<212>  DNA
<213>  Homo sapiens

<400>  5
agaaacatcc agaatacatt tccaacaaga gcactggcca agtcagcttc ttctgagaga       60

gtctctagaa gacatgatgc tacactcagc tttgggtctc tgcctcttac tcgtcacagt      120

ttcttccaac cttgccattg caataaaaaa ggaaaagagg cctcctcaga cactctcaag      180

aggatgggga gatgacatca cttgggtaca aacttatgaa gaaggtctct tttatgctca      240

aaaaagtaag aagccattaa tggttattca tcacctggag gattgtcaat actctcaagc      300

actaaagaaa gtatttgccc aaaatgaaga aatacaagaa atggctcaga ataagttcat      360

catgctaaac cttatgcatg aaaccactga taagaattta tcacctgatg ggcaatatgt      420

gcctagaatc atgtttgtag acccttcttt aacagttaga gctgacatag ctggaagata      480

ctctaacaga ttgtacacat atgagcctcg ggatttaccc ctattgatag aaaacatgaa      540

gaaagcatta agacttattc agtcagagct ataagagatg atggaaaaaa gccttcactt      600

caaagaagtc aaatttcatg aagaaaacct ctggcacatt gacaaatact aaatgtgcaa      660

gtatatagat tttgtaatat tactatttag tttttttaat gtgtttgcaa tagtcttatt      720

aaaataaatg ttttttaaat ctgagactga aaaaaaaaaa aaaaaaa                    767


<210>  6
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Met Leu His Ser Ala Leu Gly Leu Cys Leu Leu Leu Val Thr Val 
1               5                   10                  15      


Ser Ser Asn Leu Ala Ile Ala Ile Lys Lys Glu Lys Arg Pro Pro Gln 
            20                  25                  30          


Thr Leu Ser Arg Gly Trp Gly Asp Asp Ile Thr Trp Val Gln Thr Tyr 
        35                  40                  45              


Glu Glu Gly Leu Phe Tyr Ala Gln Lys Ser Lys Lys Pro Leu Met Val 
    50                  55                  60                  


Ile His His Leu Glu Asp Cys Gln Tyr Ser Gln Ala Leu Lys Lys Val 
65                  70                  75                  80  


Phe Ala Gln Asn Glu Glu Ile Gln Glu Met Ala Gln Asn Lys Phe Ile 
                85                  90                  95      


Met Leu Asn Leu Met His Glu Thr Thr Asp Lys Asn Leu Ser Pro Asp 
            100                 105                 110         


Gly Gln Tyr Val Pro Arg Ile Met Phe Val Asp Pro Ser Leu Thr Val 
        115                 120                 125             


Arg Ala Asp Ile Ala Gly Arg Tyr Ser Asn Arg Leu Tyr Thr Tyr Glu 
    130                 135                 140                 


Pro Arg Asp Leu Pro Leu Leu Ile Glu Asn Met Lys Lys Ala Leu Arg 
145                 150                 155                 160 


Leu Ile Gln Ser Glu Leu 
                165     


<210>  7
<211>  850
<212>  DNA
<213>  Homo sapiens

<400>  7
cgggagcaag agagaaggag gcccagacag tgagggcagg agggagagaa gagacgcaga       60

aggagagcga gcgagagaga aagggttctg gattggaggg gagagcaagg gagggaggaa      120

ggcggtgaga gaggcggggg cctcgggagg gtgaaaggag ggaggagaag ggcggggcac      180

ggaggcccga gcgagggaca agactccgac tccagctctg acttttttcg cggctctcgg      240

cttccactgc agccatgtca ctcctcttgc tggtggtctc agcccttcac atcctcattc      300

ttatactgct tttcgtggcc actttggaca agtcctggtg gactctccct gggaaagagt      360

ccctgaatct ctggtacgac tgcacgtgga acaacgacac caaaacatgg gcctgcagta      420

atgtcagcga gaatggctgg ctgaaggcgg tgcaggtcct catggtgctc tccctcattc      480

tctgctgtct ctccttcatc ctgttcatgt tccagctcta caccatgcga cgaggaggtc      540

tcttctatgc caccggcctc tgccagcttt gcaccagcgt ggcggtgttt actggcgcct      600

tgatctatgc cattcacgcc gaggagatcc tggagaagca cccgcgaggg ggcagcttcg      660

gatactgctt cgccctggcc tgggtggcct tccccctcgc cctggtcagc ggcatcatct      720

acatccacct acggaagcgg gagtgagcgc cccgcctcgc tcggctgccc ccgccccttc      780

ccggcccccc tcgccgcgcg tcctccaaaa aataaaacct taaccgcgga aaaaaaaaaa      840

aaaaaaaaaa                                                             850


<210>  8
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Leu Leu Leu Leu Val Val Ser Ala Leu His Ile Leu Ile Leu 
1               5                   10                  15      


Ile Leu Leu Phe Val Ala Thr Leu Asp Lys Ser Trp Trp Thr Leu Pro 
            20                  25                  30          


Gly Lys Glu Ser Leu Asn Leu Trp Tyr Asp Cys Thr Trp Asn Asn Asp 
        35                  40                  45              


Thr Lys Thr Trp Ala Cys Ser Asn Val Ser Glu Asn Gly Trp Leu Lys 
    50                  55                  60                  


Ala Val Gln Val Leu Met Val Leu Ser Leu Ile Leu Cys Cys Leu Ser 
65                  70                  75                  80  


Phe Ile Leu Phe Met Phe Gln Leu Tyr Thr Met Arg Arg Gly Gly Leu 
                85                  90                  95      


Phe Tyr Ala Thr Gly Leu Cys Gln Leu Cys Thr Ser Val Ala Val Phe 
            100                 105                 110         


Thr Gly Ala Leu Ile Tyr Ala Ile His Ala Glu Glu Ile Leu Glu Lys 
        115                 120                 125             


His Pro Arg Gly Gly Ser Phe Gly Tyr Cys Phe Ala Leu Ala Trp Val 
    130                 135                 140                 


Ala Phe Pro Leu Ala Leu Val Ser Gly Ile Ile Tyr Ile His Leu Arg 
145                 150                 155                 160 


Lys Arg Glu 
            


