                         SEQUENCE LISTING

<110>  REGENXBIO INC.
 
<120>  GENE THERAPY FOR NEURONAL CEROID LIPOFUSCINOSES

<130>  12656-125-228

<140>
<141>

<150>  US 62/924,060
<151>  2019-10-21

<150>  US 62/767,410
<151>  2018-11-14

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro 
            


<210>  2
<211>  1693
<212>  DNA
<213>  Homo sapiens

<400>  2
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgcagt       60

tacagcccgg agcccgacca gcggaggacg ctgcccccag gctgggtgtc cctgggccgt      120

gcggaccctg aggaagagct gagtctcacc tttgccctga gacagcagaa tgtggaaaga      180

ctctcggagc tggtgcaggc tgtgtcggat cccagctctc ctcaatacgg aaaatacctg      240

accctagaga atgtggctga tctggtgagg ccatccccac tgaccctcca cacggtgcaa      300

aaatggctct tggcagccgg agcccagaag tgccattctg tgatcacaca ggactttctg      360

acttgctggc tgagcatccg acaagcagag ctgctgctcc ctggggctga gtttcatcac      420

tatgtgggag gacctacgga aacccatgtt gtaaggtccc cacatcccta ccagcttcca      480

caggccttgg ccccccatgt ggactttgtg gggggactgc accgttttcc cccaacatca      540

tccctgaggc aacgtcctga gccgcaggtg acagggactg taggcctgca tctgggggta      600

accccctctg tgatccgtaa gcgatacaac ttgacctcac aagacgtggg ctctggcacc      660

agcaataaca gccaagcctg tgcccagttc ctggagcagt atttccatga ctcagacctg      720

gctcagttca tgcgcctctt cggtggcaac tttgcacatc aggcatcagt agcccgtgtg      780

gttggacaac agggccgggg ccgggccggg attgaggcca gtctagatgt gcagtacctg      840

atgagtgctg gtgccaacat ctccacctgg gtctacagta gccctggccg gcatgaggga      900

caggagccct tcctgcagtg gctcatgctg ctcagtaatg agtcagccct gccacatgtg      960

catactgtga gctatggaga tgatgaggac tccctcagca gcgcctacat ccagcgggtc     1020

aacactgagc tcatgaaggc tgccgctcgg ggtctcaccc tgctcttcgc ctcaggtgac     1080

agtggggccg ggtgttggtc tgtctctgga agacaccagt tccgccctac cttccctgcc     1140

tccagcccct atgtcaccac agtgggaggc acatccttcc aggaaccttt cctcatcaca     1200

aatgaaattg ttgactatat cagtggtggt ggcttcagca atgtgttccc acggccttca     1260

taccaggagg aagctgtaac gaagttcctg agctctagcc cccacctgcc accatccagt     1320

tacttcaatg ccagtggccg tgcctaccca gatgtggctg cactttctga tggctactgg     1380

gtggtcagca acagagtgcc cattccatgg gtgtccggaa cctcggcctc tactccagtg     1440

tttgggggga tcctatcctt gatcaatgag cacaggatcc ttagtggccg cccccctctt     1500

ggctttctca acccaaggct ctaccagcag catggggcag gactctttga tgtaacccgt     1560

ggctgccatg agtcctgtct ggatgaagag gtagagggcc agggtttctg ctctggtcct     1620

ggctgggatc ctgtaacagg ctggggaaca cccaacttcc cagctttgct gaagactcta     1680

ctcaacccct gac                                                        1693


<210>  3
<211>  1693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  3
atgggactgc aggcctgtct gctgggactg ttcgccctga tcctgagcgg caagtgcagc       60

tacagccccg agcccgacca gagaagaaca ctgcctccag gctgggtgtc cctgggcaga      120

gctgaccctg aagaggaact gagcctgacc ttcgccctgc ggcagcagaa cgtggaaaga      180

ctgagcgagc tggtgcaggc cgtgtccgat cctagcagcc ctcagtacgg caagtacctg      240

accctggaaa acgtggccga cctcgtgcgg cctagccctc tgacactgca caccgtgcag      300

aagtggctgc tggctgccgg cgctcagaaa tgccactccg tgatcaccca ggactttctg      360

acctgttggc tgagcatccg gcaggccgaa ctgctgctgc ctggggccga gtttcaccac      420

tatgtgggcg gacccaccga gacacatgtc gtgcgcagcc cacaccctta ccagctgcca      480

caggctctgg cccctcacgt ggactttgtg ggaggcctgc acagattccc cccaaccagc      540

agcctgagac agaggcctga gccacaagtg accggcacag tgggcctgca tctgggcgtg      600

acacctagcg tgatccggaa gcggtacaac ctgaccagcc aggatgtggg cagcggcacc      660

agcaacaata gccaggcctg cgcccagttc ctggaacagt acttccacga cagcgatctg      720

gcccagttca tgcggctgtt cggcggcaac ttcgcacatc aggctagcgt ggccagagtc      780

gtgggccagc agggaagagg cagagccgga attgaggcct ccctggacgt gcagtacctg      840

atgagcgctg gcgccaacat cagcacctgg gtgtacagca gccccggcag acacgagggc      900

caggaacctt ttctgcagtg gctgatgctg ctgagcaacg agagcgccct gcctcatgtg      960

cacacagtgt cctacggcga cgacgaggac agcctgagca gcgcctacat ccagagagtg     1020

aacaccgagc tgatgaaggc cgctgccagg ggactgaccc tgctgtttgc ctctggcgat     1080

agcggagccg gctgttggag tgtgtcaggc cggcaccagt tcagacccac ctttcctgcc     1140

agctccccct acgtgacaac cgtgggcggc acctcctttc aggaaccctt cctgatcacc     1200

aacgagatcg tggactacat cagcggcgga ggcttcagca acgtgttccc cagacccagc     1260

taccaggaag aggccgtgac caagttcctg tcctccagcc ctcatctgcc ccccagctcc     1320

tacttcaacg ccagcggcag agcctaccca gatgtggccg ctctgtccga cggctactgg     1380

gtggtgtcca acagagtgcc catcccttgg gtgtccggca caagcgccag cacccctgtg     1440

tttggcggca tcctgtccct gatcaacgag cacagaatcc tgtccggcag accccccctg     1500

ggcttcctga accctagact gtaccagcag cacggcgctg gcctgttcga tgtgaccaga     1560

ggctgccacg agagctgcct ggacgaggaa gtggaaggcc agggcttctg ttctggccct     1620

ggctgggatc ctgtgaccgg atggggcacc cctaacttcc ccgccctgct gaaaacactg     1680

ctgaacccct gat                                                        1693


<210>  4
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser Val Ala Arg 
1               5                   10                  15      


Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu Ala Ser Leu 
            20                  25                  30          


Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser Thr Trp Val 
        35                  40                  45              


Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe Leu Gln Trp 
    50                  55                  60                  


Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val His Thr Val 
65                  70                  75                  80  


Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr Ile Gln Arg 
                85                  90                  95      


Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu Thr Leu Leu 
            100                 105                 110         


Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val Ser Gly Arg 
        115                 120                 125             


His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr Val Thr Thr 
    130                 135                 140                 


Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr Asn Glu Ile 
145                 150                 155                 160 


Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe Pro Arg Pro 
                165                 170                 175     


Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser Ser Pro His 
            180                 185                 190         


Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala Tyr Pro Asp 
        195                 200                 205             


Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn Arg Val Pro 
    210                 215                 220                 


Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val Phe Gly Gly 
225                 230                 235                 240 


Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly Arg Pro Pro 
                245                 250                 255     


Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly Ala Gly Leu 
            260                 265                 270         


Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp Glu Glu Val 
        275                 280                 285             


Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro Val Thr Gly 
    290                 295                 300                 


Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu Leu Asn Pro 
305                 310                 315                 320 


<210>  5
<211>  6841
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  5
tcgaggacgg ggtgaactac gcctgaggat ccgatctttt tccctctgcc aaaaattatg       60

gggacatcat gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca      120

ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagcaattcg ttgatctgaa      180

tttcgaccac ccataatacc cattaccctg gtagataagt agcatggcgg gttaatcatt      240

aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc      300

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg      360

agcgagcgag cgcgcagcct taattaacct aattcactgg ccgtcgtttt acaacgtcgt      420

gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc      480

agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg      540

aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg      600

cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct      660

tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta      720

gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt      780

tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg      840

ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat      900

tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt      960

taacaaaaat ttaacgcgaa ttttaacaaa atattaacgc ttacaattta ggtggcactt     1020

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt     1080

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta     1140

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg     1200

tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac     1260

gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg     1320

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc     1380

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg     1440

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat     1500

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg     1560

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg     1620

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc     1680

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt     1740

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct     1800

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc     1860

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca     1920

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct     1980

cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt     2040

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga     2100

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca     2160

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac     2220

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg     2280

taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag     2340

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac     2400

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     2460

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     2520

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     2580

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     2640

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     2700

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     2760

acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt     2820

tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg     2880

ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag     2940

agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc     3000

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc     3060

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa     3120

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccagattta     3180

attaaggcct taattaggct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc     3240

gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga     3300

gtggccaact ccatcactag gggttccttg tagttaatga ttaacccgcc atgctactta     3360

tctaccaggg taatggggat cctctagaac tatagctagt cgacattgat tattgactag     3420

ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt     3480

tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac     3540

gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg     3600

ggtggactat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag     3660

tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat     3720

gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat     3780

ggtcgaggtg agccccacgt tctgcttcac tctccccatc tcccccccct ccccaccccc     3840

aattttgtat ttatttattt tttaattatt ttgtgcagcg atgggggcgg gggggggggg     3900

ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg ggcggggcga ggcggagagg     3960

tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt ccttttatgg cgaggcggcg     4020

gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg gggagtcgct gcgacgctgc     4080

cttcgccccg tgccccgctc cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc     4140

gcgttactcc cacaggtgag cgggcgggac ggcccttctc ctccgggctg taattagcgc     4200

ttggtttaat gacggcttgt ttcttttctg tggctgcgtg aaagccttga ggggctccgg     4260

gagggccctt tgtgcggggg gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg     4320

agcgccgcgt gcggctccgc gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg     4380

ctttgtgcgc tccgcagtgt gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc     4440

ggggggggct gcgaggggaa caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca     4500

gggggtgtgg gcgcgtcggt cgggctgcaa ccccccctgc acccccctcc ccgagttgct     4560

gagcacggcc cggcttcggg tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg     4620

ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg     4680

gagggctcgg gggaggggcg cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg     4740

agccgcagcc attgcctttt atggtaatcg tgcgagaggg cgcagggact tcctttgtcc     4800

caaatctgtg cggagccgaa atctgggagg cgccgccgca ccccctctag cgggcgcggg     4860

gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg agggccttcg tgcgtcgccg     4920

cgccgccgtc cccttctccc tctccagcct cggggctgtc cgcgggggga cggctgcctt     4980

cgggggggac ggggcagggc ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc     5040

tctgctaacc atgttcatgc cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt     5100

attgtgctgt ctcatcattt tggcaaagaa ttcacgcgtg ccaccatggg actgcaggcc     5160

tgtctgctgg gactgttcgc cctgatcctg agcggcaagt gcagctacag ccccgagccc     5220

gaccagagaa gaacactgcc tccaggctgg gtgtccctgg gcagagctga ccctgaagag     5280

gaactgagcc tgaccttcgc cctgcggcag cagaacgtgg aaagactgag cgagctggtg     5340

caggccgtgt ccgatcctag cagccctcag tacggcaagt acctgaccct ggaaaacgtg     5400

gccgacctcg tgcggcctag ccctctgaca ctgcacaccg tgcagaagtg gctgctggct     5460

gccggcgctc agaaatgcca ctccgtgatc acccaggact ttctgacctg ttggctgagc     5520

atccggcagg ccgaactgct gctgcctggg gccgagtttc accactatgt gggcggaccc     5580

accgagacac atgtcgtgcg cagcccacac ccttaccagc tgccacaggc tctggcccct     5640

cacgtggact ttgtgggagg cctgcacaga ttccccccaa ccagcagcct gagacagagg     5700

cctgagccac aagtgaccgg cacagtgggc ctgcatctgg gcgtgacacc tagcgtgatc     5760

cggaagcggt acaacctgac cagccaggat gtgggcagcg gcaccagcaa caatagccag     5820

gcctgcgccc agttcctgga acagtacttc cacgacagcg atctggccca gttcatgcgg     5880

ctgttcggcg gcaacttcgc acatcaggct agcgtggcca gagtcgtggg ccagcaggga     5940

agaggcagag ccggaattga ggcctccctg gacgtgcagt acctgatgag cgctggcgcc     6000

aacatcagca cctgggtgta cagcagcccc ggcagacacg agggccagga accttttctg     6060

cagtggctga tgctgctgag caacgagagc gccctgcctc atgtgcacac agtgtcctac     6120

ggcgacgacg aggacagcct gagcagcgcc tacatccaga gagtgaacac cgagctgatg     6180

aaggccgctg ccaggggact gaccctgctg tttgcctctg gcgatagcgg agccggctgt     6240

tggagtgtgt caggccggca ccagttcaga cccacctttc ctgccagctc cccctacgtg     6300

acaaccgtgg gcggcacctc ctttcaggaa cccttcctga tcaccaacga gatcgtggac     6360

tacatcagcg gcggaggctt cagcaacgtg ttccccagac ccagctacca ggaagaggcc     6420

gtgaccaagt tcctgtcctc cagccctcat ctgcccccca gctcctactt caacgccagc     6480

ggcagagcct acccagatgt ggccgctctg tccgacggct actgggtggt gtccaacaga     6540

gtgcccatcc cttgggtgtc cggcacaagc gccagcaccc ctgtgtttgg cggcatcctg     6600

tccctgatca acgagcacag aatcctgtcc ggcagacccc ccctgggctt cctgaaccct     6660

agactgtacc agcagcacgg cgctggcctg ttcgatgtga ccagaggctg ccacgagagc     6720

tgcctggacg aggaagtgga aggccagggc ttctgttctg gccctggctg ggatcctgtg     6780

accggatggg gcacccctaa cttccccgcc ctgctgaaaa cactgctgaa cccctgatga     6840

c                                                                     6841


<210>  6
<211>  736
<212>  PRT
<213>  adeno-associated virus 9

<400>  6

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  7
<211>  2211
<212>  DNA
<213>  adeno-associated virus 9

<400>  7
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210>  8
<211>  4020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  8
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggact atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattcacgcg tgccaccatg ggactgcagg cctgtctgct gggactgttc     1980

gccctgatcc tgagcggcaa gtgcagctac agccccgagc ccgaccagag aagaacactg     2040

cctccaggct gggtgtccct gggcagagct gaccctgaag aggaactgag cctgaccttc     2100

gccctgcggc agcagaacgt ggaaagactg agcgagctgg tgcaggccgt gtccgatcct     2160

agcagccctc agtacggcaa gtacctgacc ctggaaaacg tggccgacct cgtgcggcct     2220

agccctctga cactgcacac cgtgcagaag tggctgctgg ctgccggcgc tcagaaatgc     2280

cactccgtga tcacccagga ctttctgacc tgttggctga gcatccggca ggccgaactg     2340

ctgctgcctg gggccgagtt tcaccactat gtgggcggac ccaccgagac acatgtcgtg     2400

cgcagcccac acccttacca gctgccacag gctctggccc ctcacgtgga ctttgtggga     2460

ggcctgcaca gattcccccc aaccagcagc ctgagacaga ggcctgagcc acaagtgacc     2520

ggcacagtgg gcctgcatct gggcgtgaca cctagcgtga tccggaagcg gtacaacctg     2580

accagccagg atgtgggcag cggcaccagc aacaatagcc aggcctgcgc ccagttcctg     2640

gaacagtact tccacgacag cgatctggcc cagttcatgc ggctgttcgg cggcaacttc     2700

gcacatcagg ctagcgtggc cagagtcgtg ggccagcagg gaagaggcag agccggaatt     2760

gaggcctccc tggacgtgca gtacctgatg agcgctggcg ccaacatcag cacctgggtg     2820

tacagcagcc ccggcagaca cgagggccag gaaccttttc tgcagtggct gatgctgctg     2880

agcaacgaga gcgccctgcc tcatgtgcac acagtgtcct acggcgacga cgaggacagc     2940

ctgagcagcg cctacatcca gagagtgaac accgagctga tgaaggccgc tgccagggga     3000

ctgaccctgc tgtttgcctc tggcgatagc ggagccggct gttggagtgt gtcaggccgg     3060

caccagttca gacccacctt tcctgccagc tccccctacg tgacaaccgt gggcggcacc     3120

tcctttcagg aacccttcct gatcaccaac gagatcgtgg actacatcag cggcggaggc     3180

ttcagcaacg tgttccccag acccagctac caggaagagg ccgtgaccaa gttcctgtcc     3240

tccagccctc atctgccccc cagctcctac ttcaacgcca gcggcagagc ctacccagat     3300

gtggccgctc tgtccgacgg ctactgggtg gtgtccaaca gagtgcccat cccttgggtg     3360

tccggcacaa gcgccagcac ccctgtgttt ggcggcatcc tgtccctgat caacgagcac     3420

agaatcctgt ccggcagacc ccccctgggc ttcctgaacc ctagactgta ccagcagcac     3480

ggcgctggcc tgttcgatgt gaccagaggc tgccacgaga gctgcctgga cgaggaagtg     3540

gaaggccagg gcttctgttc tggccctggc tgggatcctg tgaccggatg gggcacccct     3600

aacttccccg ccctgctgaa aacactgctg aacccctgat gactcgagga cggggtgaac     3660

tacgcctgag gatccgatct ttttccctct gccaaaaatt atggggacat catgaagccc     3720

cttgagcatc tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg     3780

aattttttgt gtctctcact cggaagcaat tcgttgatct gaatttcgac cacccataat     3840

acccattacc ctggtagata agtagcatgg cgggttaatc attaactaca aggaacccct     3900

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     3960

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag     4020


