                         SEQUENCE LISTING

<110>  Broad Institute, Inc.
 
<120>  USE OF DISULFIRAM AND OTHER COMPOUNDS TO TREAT CANCERS WITH LOSS 
       OF CHROMOSOME 16Q AND/OR LOW EXPRESSION OF METHALLOTHIONEIN 
       PROTEINS

<130>  52199-541001WO

<150>  62/767,478
<151>  2018-11-14

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  175
<212>  DNA
<213>  Homo sapiens

<400>  1
catcggagaa gtgcagctgc tgtgcctgat gtgggaacag ctcttctccc agatgtaaat       60

agaacaacct gcacaacctg gattttttta aaaatacaac actgagccat ttgctgcatt      120

tctttttata ctaaatatgt gactgacaat aaaaacaatt ttgactttaa tctta           175


<210>  2
<211>  519
<212>  DNA
<213>  Homo sapiens

<400>  2
aggaacgcgg gcggtgcgga ctcagcgggc cgggtgcagg cgcggagctg ggcctctgcg       60

cccggcccga cctccgtcta taaatagagc agccagttgc agggctccat tctgctttcc      120

aactgcctga ctgcttgttc gtctcactgg tgtgagctcc agcatcccct ttgctcgaaa      180

tggaccccaa ctgctcttgc gccactggtg gctcctgcac gtgcgccggc tcctgcaagt      240

gcaaagagtg caaatgcacc tcctgcaaga agagctgctg ttcctgctgc cccgtgggct      300

gtgccaagtg tgcccagggc tgcgtctgca aaggggcatc ggagaagtgc agctgctgtg      360

cctgatgtgg gaacagctct tctcccagat gtaaatagaa caacctgcac aacctggatt      420

tttttaaaaa tacaacactg agccatttgc tgcatttctt tttatactaa atatgtgact      480

gacaataaaa acaattttga ctttaaaaaa aaaaaaaaa                             519


<210>  3
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Pro Asn Cys Ser Cys Ala Thr Gly Gly Ser Cys Thr Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Glu Cys Gly Ala Ile Ser Arg Asn Leu Gly Leu Trp Leu Arg Leu Gly 
        35                  40                  45              


Gly Asn Ser Arg Leu Ala Leu Ser Ala Ser Phe Trp Gly Thr Gly Leu 
    50                  55                  60                  


Ser Leu Pro Ser Leu Pro Val Ser Phe Pro Leu Gln Ala Phe Cys Pro 
65                  70                  75                  80  


Lys Phe Arg Trp Gly Arg Thr Ala Phe Phe Ser Trp Asp Thr Asn Pro 
                85                  90                  95      


Asn Cys Thr Pro Tyr Gly Phe Arg Thr Glu Leu Cys Gln Thr Lys Lys 
            100                 105                 110         


Ser Ile Leu Trp Val Trp Val Leu Ser Ser Ser Gln Ala Cys Tyr 
        115                 120                 125         


<210>  4
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Pro Asn Cys Ser Cys Ala Thr Gly Gly Ser Cys Thr Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Val Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210>  5
<211>  499
<212>  DNA
<213>  Homo sapiens

<400>  5
actcgtcccg gctctttcta gctataaaca ctgcttgccg cgctgcactc caccacgcct       60

cctccaagtc ccagcgaacc cgcgtgcaac ctgtcccgac tctagccgcc tcttcagctc      120

gccatggatc ccaactgctc ctgcgccgcc ggtgactcct gcacctgcgc cggctcctgc      180

aaatgcaaag agtgcaaatg cacctcctgc aagaaaagct gctgctcctg ctgccctgtg      240

ggctgtgcca agtgtgccca gggctgcatc tgcaaagggg cgtcggacaa gtgcagctgc      300

tgcgcctgat gctgggacag ccccgctccc agatgtaaag aacgcgactt ccacaaacct      360

ggatttttta tgtacaaccc tgaccgtgac cgtttgctat attccttttt ctatgaaata      420

atgtgaatga taataaaaca gctttgactt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      480

aaaaaaaaaa aaaaaaaaa                                                   499


<210>  6
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Asp Ser Cys Thr Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Gly Ala Ser Asp Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210>  7
<211>  7986
<212>  DNA
<213>  Homo sapiens

<400>  7
ggaagtgacg ttaggggaag gtgggggcaa tcatggtgcc gctggggagg ggagaagctg       60

ctgctgccgc cgttgccggg agccgcggag acaagtcatt acgttttcat ttctcacaac      120

tgggctgagc acaactgaac catgggggaa cacagtccag acaacaacat catctacttt      180

gaggcagagg aagatgagct gacccccgat gataaaatgc tcaggtttgt ggataaaaac      240

ggactggtgc cttcctcatc tggaactgtt tatgatagga ccactgttct tattgagcag      300

gaccctggca ctttggagga tgaagatgac gacggacagt gcggagaaca cttgcctttt      360

ctagtagggg gtgaagaggg ctttcacctg atagatcatg aagcaatgtc ccagggttat      420

gtgcagcaca ttatctcacc agatcagatt catttgacaa taaaccctgg ttccacaccc      480

atgccaagaa atattgaagg tgcaaccctc actctgcagt cggaatgtcc ggaaacaaaa      540

cgtaaagaag taaagcggta ccaatgtacc tttgagggct gtccccgcac ctacagcaca      600

gcaggcaacc tgcgaaccca ccagaagact caccgaggag agtacacctt tgtctgtaat      660

caggagggct gtggcaaagc cttccttacc tcttacagcc tcaggatcca cgtgcgagtg      720

cacacgaagg agaagccatt tgagtgtgac gtgcagggct gtgagaaggc attcaacaca      780

ctgtacaggc tgaaagcaca tcagaggctt cacacaggga aaacgtttaa ctgtgaatct      840

gaaggctgca gcaaatactt caccacactc agtgatctga ggaagcacat tcgaactcat      900

acaggggaaa agccatttcg gtgcgatcac gatggctgtg gaaaagcatt tgcagcaagc      960

caccacctta aaactcacgt tcgtacacat actggtgaaa gacccttctt ctgccccagt     1020

aatggctgtg agaaaacatt cagcactcaa tacagtctca aaagtcacat gaaaggtcat     1080

gataacaaag gacactcata caatgcactt ccacaacaca atggatcaga ggatacaaat     1140

cactcacttt gtctaagtga cttgagcctt ctgtccacag attctgaatt gcgagaaaat     1200

tccagtacga cccagggcca ggacctcagc acaatttcac cagcaatcat ctttgaatca     1260

atgttccaga attcagatga tacggcaatt caggaagatc ctcaacagac agcttccttg     1320

actgaaagtt ttaatggtga tgcagagtca gtcagtgatg ttccgccatc cacaggaaat     1380

tcagcatctt tatctcttcc acttgtactg caacctggcc tctccgagcc accccagcct     1440

ctactacctg cctcagctcc gtctgctcct ccgcctgctc cctccctagg acctggctcc     1500

cagcaagctg catttggcaa cccccctgct ctcttacaac ctccagaagt gcctgttccc     1560

cacagcacac agtttgctgc taatcatcaa gagtttcttc cgcaccccca ggcaccgcag     1620

cccattgtac caggactttc tgttgttgct ggggcttctg catcagcagc ggcagtggca     1680

tcagctgtgg cagcaccagc cccaccacaa agtactactg agcccctgcc agccatggtc     1740

cagactctgc ccctgggtgc caactctgtc ctaactaata atcccacaat aaccatcacc     1800

ccaactccca acacagctat cctgcagtcc agcctagtca tgggagaaca gaacttacaa     1860

tggatattaa atggtgccac cagttctcca caaaaccaag aacaaattca gcaagcatct     1920

aaagttgaga aggtgttttt taccactgca gtaccagtag ccagtagccc agggagctct     1980

gtccagcaga ttggcctcag tgttcctgtg atcatcatca aacaagaaga ggcatgtcag     2040

tgtcagtgtg catgccggga ctctgcaaag gagcgggcat ccagcaggag aaagggctgc     2100

tcctccccac cccctccaga gccgagcccc caggctcctg atgggcccag cctgcagctc     2160

ccagcgcaga ctttctcttc agcccctgtt cccgggtcat catcctctac cttgccctcc     2220

tcctgtgagc aaagccgaca agcagagact ccttcagacc ctcagacaga aacattaagt     2280

gccatggatg tgtcagagtt tctatccctc cagagcctgg acaccccgtc caatctgatt     2340

cccattgaag cactactgca gggggaggag gagatgggcc tcaccagcag cttctccaag     2400

tgaagggccc atgtgtgctc acctctggga aaagcgggtg agcaggaggc atgaggtaca     2460

atgcctgcca tcatgggtca gaaatttgaa ggatgaagaa atctactgtt tgaaatcctc     2520

acctttcaga cgtattttct ttattcacat cccaggagca tccattttaa ggaactattc     2580

tttggaaaaa aacaaaaaac aaaaaaaaca acaaaaaaag ctaagttata agtgaactgt     2640

ttggctgcac tgtatgtcac ttttgcttgt tgtcatgtga acttggaaac taaggttact     2700

cgtgtgcata aaaattctaa atgaaagggt gtggtttcca tcaatctgat gctgcccatc     2760

gcttgcactg gggtctttgt ggatcgggca ggagttttca gtgtgttggg tgttgctcct     2820

tcctatgtgt cttttgaatc tgaggctgac atttgcttgg aaggccagac ccttgctcca     2880

tcagagaggg cagtggcaaa ggccagtgag gcagctgtga gttggacagg gttcaggtga     2940

gatggtgttg tcatttgtgc ttagtgttgg tggtgctcag ggtggataac acgggtcgtt     3000

ctgcagcccg cttcagcaca aataggcagc ttaaggcctg gctcacaggc tgtggggttg     3060

atctggctct gcagaggccc taggcagctt gttgactgct gtctgttgat gacgtgtgtg     3120

caaagcaggc tctagcaaca tgatcactgt ccttgccttc ctggttcttt ctctcggttg     3180

gttgccaggg cttgcagatc gcagtgaatt ttccttgggg aacatcgctg ttttgtccta     3240

gagtgaactt gtggcttatg gccagtgctg tttggtggtc tgccttcttt ttaatggtat     3300

tttcttcctc agagcagaag ggctgcattt tgcttatcag aagaaggtgc agatttaagg     3360

gaattcatat gaggtggcat gtaattggca ggccaggtgt cctggttcca ggttccagcc     3420

aggctttggg ttgccccctc catctctgcc cccctctgga ttttgcatac agcctcatac     3480

agtgcaaaca aggatgtgac ttgctcagct tagtcatgtg atttatttaa aaaaaaaaaa     3540

aaaagaaaca caaaacgatg atcttctact cagggtatag caaaacaaaa aaattccctt     3600

tccaccaaaa agcctgaaat gttgcaataa gttatctcat ttggaatgtt tcattaagtt     3660

gtgttatagg aaaaaattgt gtgtgtgtgt tatagaatta tatccatatg tctgcctttg     3720

gctccaagtc attgcctctt aaaataaaag atacaatcca tactagcatg aaaagtttcc     3780

ctcaacaggc tatattaaca tagtcatgag tgctgaccaa actcaccgag ctcagaggcc     3840

aggcatggcc tgaggtgcag aataggcctc tgcctcccaa gagccctttc cttgccctga     3900

gcaaggagtg gtgttccaca aacaaggctg ctcttctaag ccaacagtgt caggcaggaa     3960

gcagccataa ttttgccttg cattttcatt ccctaatgta aagggatctg cattggtcac     4020

tctcctgttc tctgagccat tgctcagggc cagccaagat attattgaga acagataatt     4080

taccttggag ccagaggccc tccctgcctt tagcaaggat gttcagggac agacaaagag     4140

ggcagtggtg gtgaatgttg ttactgccat gaggagaaat ggcagtaaga aatcttaact     4200

acaagcagcc aatttctcat tccaggaccc tagccagaat aattgacttc tttttttttt     4260

tgagacagag ttttgctttt gttgccctgg ctggagtgca gtggcgcaat cttggctcac     4320

cgcaacctcc acttcccagg ttcaagcaat tctgcctcag cctcccgagt agctgggatt     4380

acaggcatgc gccaccacgc ctggctaatt ttgtattttt agtagagacg gggtttctcc     4440

atgttggtca ggctggtctc gaactcccaa cgtcaggtga tcctcccgcc tcagtctccc     4500

aaagtgctgg gattacaggt gtgagccacc atgcctggtc tagggaattg acttcttttt     4560

gaccttctgc actcccttcc ccaaaaggat tgtggcttct gttgaccatt gacctcagca     4620

gaagttgata aggcaggagg tttccagtcc tcctggaaaa ccaactgctg agcatgagtt     4680

gtccttggct gtctctgggc ctcgcaccca tgggaagttt tgaggtaggg cccttgctgt     4740

ttacaacttc tgagagagta gtgatgggac cccaaagtaa gcttgtatca gagggcagta     4800

atgaccttcc catatcccca tcctgtggtc acctgggatt tgggttccct ggggcggaag     4860

tgggaaatag gagcccaggg aaggacatct gaagcaccca cagtttaaat agcgactctt     4920

cttggttagc cagggctgtg ctcatgttgg gccctaccca ggtcagtggc cttttcactc     4980

tcaaagatcg ggggtgacga agcagcatct taaacagtgt ttaggctgac agatttttcc     5040

agttgaagaa gctgaagtat ctgccttttg agggtgactc tagattacaa gagagactat     5100

cagatccaat cagcttttga aaaatcagga atgtgcttaa aatgccagtg agtggttgtg     5160

aagatcaggt ttatttccca ggataggcag tctttctttc cctccttttc cagttctctt     5220

ttcctacctg tccttccata agcctggtct ctagtgccga ggaccttgga gaagagaggg     5280

cccctagcta agctggagcc agaaagaacc ttcatggtga gtgtggtttc ccaaacttgg     5340

gaaatgaacc tagggtgagg ttagggagga tttgtagaat tctagcaggt aaaaatcaag     5400

cctttttccc ctcccatagt aaacttaacc attttcaccc tgtacgttat cttctagctc     5460

ctactaacat ctccaattag acaaccgctt caaagggtgc ttagcaccag ggattggggt     5520

tcatggactt aggaggtggt aaggaaactg gctggcacca ccaaactgcc ttagtgaact     5580

tggcccttcc caggcaggta ggttgggcat tgagggaagg tggcccagtc tttgctggca     5640

gggtctggcc agtctcatgg gggcaccacc agtttggtga cagaagtggt gtcatttatt     5700

gaattccacc tccgtttaga aggagatcat ggtacaaagc ccaggagggg ccttaagatg     5760

tgaagatctc tctgagtaaa aggcaagggg cttctcttct tcacctctgg gatagttggt     5820

agatcggaga gttttatttt cagggtcaag gctgtggact gatggggata ttggagggtg     5880

ggtgggtttt cctgagagac tttgtataat gctgaatgtg tccagaggga caagtttgca     5940

gaacctcata ttggtatatt aaagaaataa taaaataaaa aagcacttta ggttatttta     6000

tctttaaccc gattgctgca atttcttttg tgtgtatata tacatatata tactttccac     6060

aaagttttat tttttgctca gaataaaaag ttaaattgag gtgtgaaaag aaaagcactt     6120

accttggtgc aatatgtgta gcttgatggt cgttgtccca tgtggccctg gcctggcagc     6180

gtttttccgc tcaatcagcc ctgtgctgtg agactgtcca tagggaaaca ctattatgca     6240

ttctcagcaa ccgctcaatc tatgcaagcc ttccctgtgt gccccagggc gccccctcag     6300

gctctctgaa gaactgctgt gggtcctgtt ttctgctgac tgttgaggcc ctttttcatc     6360

acttcttggt ctctcgccat cttttccctc ttcaccatta caaaatgatg cctgaaagga     6420

aggaacagat tgttcctagg tagaaacctg gcaccttcta gacttttata tttgtaatca     6480

catccattgt ccttaaagac ttttccagag tgattgaaac cattgatttg tggaactgca     6540

acaatatttc tcaagagttt acaattgtct tacaccacca atcagaaata tgtttgggga     6600

ggcatgggtg gcagggggca acatgagcca tttccatact gctccccata ctacctgtgt     6660

tggttcctta agcaaaaagg cctccagcct tcattaaatc ctataaacaa acattacatc     6720

ccatgaatca ttatcaactt tcttccttta ctccacctcc cccattttat cttcaattct     6780

caggctatag aatagacaag ttttagaata tacttcagcc aaagcagaag gattttcata     6840

gatccaatat gcaaatagtt ctgctgtgac atagatcaga aattgtctgt tccttaatat     6900

ttgggggtgg aggcaacaaa actgaagcat atttctgatt ggttagccat tttggcctgt     6960

ttcctcttgc atgtttttta gggagagagg gaaacagtcc tgtatttctt ctgatgccct     7020

ttggggaagc cgacgaccac tgggcatttc tcactgttac tcctgttcaa gagagggctt     7080

ctcagtctgc actgaaaaat gcaaattaaa ctggatcttt atgtcaatgt gtacatagta     7140

caagcttttt tactggaatt gaggtttaaa accacacact gcccttttgg tggtgtgcct     7200

gttgggccaa aaattgggtg ataatgtagt gtcactttct cagctcaatg cagtttctac     7260

tttttcttat gggaaaattt ttcataaaac ctttttgcac caaaacccag gggtgttttt     7320

tgcaatatcc ttgttatcct cgtagtgtgc caagtcagag gctttctctt gcccttttcc     7380

tgctgtgttc tcaggcctcc caagggctat ttgactcaac agtctacatc cttcgttgtg     7440

ttttggagaa tgtgggggtg ggggtcagag ttcaaggtgt ctgttccctt ttcctgtgaa     7500

ctctttctag tccctatttg gggagggtgg ctggaaacag atttttgctg aatttctggc     7560

tcagatcttc tagccaggaa aggcaagagc ccccaagagc cctttttttt gacatacact     7620

aatcattggc cggggtcttg gtgacaactt ttaaaatccc aaatagtttt atttggatta     7680

tgtaaaagta agtgtgaaac atgggaacaa cggacttcca ctgagcgatg tgaaaacgtt     7740

acaggttcag tacttccaaa ggaagaaacc tccaaaccca aaaaagaata aatatgaatt     7800

tgtatttttg aagaatgtga aataatggtg tttgcttaat tgctcatttt gtataaactt     7860

aatattgtac tttaaaatat ctgctaaaaa gtgaaaattt aactttttgg aattgaaaaa     7920

gcaatattaa atactaatga aatcctaatt aaatgcttat ttaaatctgg taaaaaaaaa     7980

aaaaaa                                                                7986


<210>  8
<211>  753
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Glu His Ser Pro Asp Asn Asn Ile Ile Tyr Phe Glu Ala Glu 
1               5                   10                  15      


Glu Asp Glu Leu Thr Pro Asp Asp Lys Met Leu Arg Phe Val Asp Lys 
            20                  25                  30          


Asn Gly Leu Val Pro Ser Ser Ser Gly Thr Val Tyr Asp Arg Thr Thr 
        35                  40                  45              


Val Leu Ile Glu Gln Asp Pro Gly Thr Leu Glu Asp Glu Asp Asp Asp 
    50                  55                  60                  


Gly Gln Cys Gly Glu His Leu Pro Phe Leu Val Gly Gly Glu Glu Gly 
65                  70                  75                  80  


Phe His Leu Ile Asp His Glu Ala Met Ser Gln Gly Tyr Val Gln His 
                85                  90                  95      


Ile Ile Ser Pro Asp Gln Ile His Leu Thr Ile Asn Pro Gly Ser Thr 
            100                 105                 110         


Pro Met Pro Arg Asn Ile Glu Gly Ala Thr Leu Thr Leu Gln Ser Glu 
        115                 120                 125             


Cys Pro Glu Thr Lys Arg Lys Glu Val Lys Arg Tyr Gln Cys Thr Phe 
    130                 135                 140                 


Glu Gly Cys Pro Arg Thr Tyr Ser Thr Ala Gly Asn Leu Arg Thr His 
145                 150                 155                 160 


Gln Lys Thr His Arg Gly Glu Tyr Thr Phe Val Cys Asn Gln Glu Gly 
                165                 170                 175     


Cys Gly Lys Ala Phe Leu Thr Ser Tyr Ser Leu Arg Ile His Val Arg 
            180                 185                 190         


Val His Thr Lys Glu Lys Pro Phe Glu Cys Asp Val Gln Gly Cys Glu 
        195                 200                 205             


Lys Ala Phe Asn Thr Leu Tyr Arg Leu Lys Ala His Gln Arg Leu His 
    210                 215                 220                 


Thr Gly Lys Thr Phe Asn Cys Glu Ser Glu Gly Cys Ser Lys Tyr Phe 
225                 230                 235                 240 


Thr Thr Leu Ser Asp Leu Arg Lys His Ile Arg Thr His Thr Gly Glu 
                245                 250                 255     


Lys Pro Phe Arg Cys Asp His Asp Gly Cys Gly Lys Ala Phe Ala Ala 
            260                 265                 270         


Ser His His Leu Lys Thr His Val Arg Thr His Thr Gly Glu Arg Pro 
        275                 280                 285             


Phe Phe Cys Pro Ser Asn Gly Cys Glu Lys Thr Phe Ser Thr Gln Tyr 
    290                 295                 300                 


Ser Leu Lys Ser His Met Lys Gly His Asp Asn Lys Gly His Ser Tyr 
305                 310                 315                 320 


Asn Ala Leu Pro Gln His Asn Gly Ser Glu Asp Thr Asn His Ser Leu 
                325                 330                 335     


Cys Leu Ser Asp Leu Ser Leu Leu Ser Thr Asp Ser Glu Leu Arg Glu 
            340                 345                 350         


Asn Ser Ser Thr Thr Gln Gly Gln Asp Leu Ser Thr Ile Ser Pro Ala 
        355                 360                 365             


Ile Ile Phe Glu Ser Met Phe Gln Asn Ser Asp Asp Thr Ala Ile Gln 
    370                 375                 380                 


Glu Asp Pro Gln Gln Thr Ala Ser Leu Thr Glu Ser Phe Asn Gly Asp 
385                 390                 395                 400 


Ala Glu Ser Val Ser Asp Val Pro Pro Ser Thr Gly Asn Ser Ala Ser 
                405                 410                 415     


Leu Ser Leu Pro Leu Val Leu Gln Pro Gly Leu Ser Glu Pro Pro Gln 
            420                 425                 430         


Pro Leu Leu Pro Ala Ser Ala Pro Ser Ala Pro Pro Pro Ala Pro Ser 
        435                 440                 445             


Leu Gly Pro Gly Ser Gln Gln Ala Ala Phe Gly Asn Pro Pro Ala Leu 
    450                 455                 460                 


Leu Gln Pro Pro Glu Val Pro Val Pro His Ser Thr Gln Phe Ala Ala 
465                 470                 475                 480 


Asn His Gln Glu Phe Leu Pro His Pro Gln Ala Pro Gln Pro Ile Val 
                485                 490                 495     


Pro Gly Leu Ser Val Val Ala Gly Ala Ser Ala Ser Ala Ala Ala Val 
            500                 505                 510         


Ala Ser Ala Val Ala Ala Pro Ala Pro Pro Gln Ser Thr Thr Glu Pro 
        515                 520                 525             


Leu Pro Ala Met Val Gln Thr Leu Pro Leu Gly Ala Asn Ser Val Leu 
    530                 535                 540                 


Thr Asn Asn Pro Thr Ile Thr Ile Thr Pro Thr Pro Asn Thr Ala Ile 
545                 550                 555                 560 


Leu Gln Ser Ser Leu Val Met Gly Glu Gln Asn Leu Gln Trp Ile Leu 
                565                 570                 575     


Asn Gly Ala Thr Ser Ser Pro Gln Asn Gln Glu Gln Ile Gln Gln Ala 
            580                 585                 590         


Ser Lys Val Glu Lys Val Phe Phe Thr Thr Ala Val Pro Val Ala Ser 
        595                 600                 605             


Ser Pro Gly Ser Ser Val Gln Gln Ile Gly Leu Ser Val Pro Val Ile 
    610                 615                 620                 


Ile Ile Lys Gln Glu Glu Ala Cys Gln Cys Gln Cys Ala Cys Arg Asp 
625                 630                 635                 640 


Ser Ala Lys Glu Arg Ala Ser Ser Arg Arg Lys Gly Cys Ser Ser Pro 
                645                 650                 655     


Pro Pro Pro Glu Pro Ser Pro Gln Ala Pro Asp Gly Pro Ser Leu Gln 
            660                 665                 670         


Leu Pro Ala Gln Thr Phe Ser Ser Ala Pro Val Pro Gly Ser Ser Ser 
        675                 680                 685             


Ser Thr Leu Pro Ser Ser Cys Glu Gln Ser Arg Gln Ala Glu Thr Pro 
    690                 695                 700                 


Ser Asp Pro Gln Thr Glu Thr Leu Ser Ala Met Asp Val Ser Glu Phe 
705                 710                 715                 720 


Leu Ser Leu Gln Ser Leu Asp Thr Pro Ser Asn Leu Ile Pro Ile Glu 
                725                 730                 735     


Ala Leu Leu Gln Gly Glu Glu Glu Met Gly Leu Thr Ser Ser Phe Ser 
            740                 745                 750         


Lys 
    


