                         SEQUENCE LISTING

<110>  Broad Institute, Inc.
 
<120>  VANADIUM COMPOSITIONS AND METHOD FOR TREATMENTS OF CANCER

<130>  52199-540001WO

<150>  62/767,345
<151>  2018-11-14

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  8082
<212>  DNA
<213>  Homo sapiens

<400>  1
gtgacggcct cggccgcggg cgtttacact ggctctgcct ccggcatctc ttcgccggtg       60

cgtcctcgcc gcgcccgtag gtcccggcag ccgggccccg cctccttcgg agtccgagcg      120

atgggcgggg aaagggacag gcaggtatag ctctgtcggc gccgcggtgt ccacctcagt      180

caggccacgg tggaagacgc gtgccgcggc gcctggttgc ctgcagcggc ccggacccga      240

gaggaagctg aaccatctat ctccagaaat gtcttcagaa agtaaagagc aacataacgt      300

ttcacccaga gactcagctg aaggaaatga cagttatcca tctgggatcc atctggaact      360

tcaaagggaa tcaagtactg acttcaagca atttgagacc aatgatcaat gcagacctta      420

tcataggatc cttattgagc gtcaagagaa atcagataca aacttcaagg agtttgttat      480

taaaaagctg cagaagaatt gccagtgcag tccagccaaa gccaaaaata tgattttagg      540

tttccttcct gttttgcagt ggctcccaaa atacgaccta aagaaaaaca ttttagggga      600

tgtgatgtca ggcttgattg tgggcatatt attggtgccc cagtccattg cttattccct      660

gctggctggc caagaacctg tctatggtct gtacacatct ttttttgcca gcatcattta      720

ttttctcttg ggtacctccc gtcacatctc tgtgggcatt tttggagtac tgtgccttat      780

gattggtgag acagttgacc gagaactaca gaaagctggc tatgacaatg cccatagtgc      840

tccttcctta ggaatggttt caaatgggag cacattatta aatcatacat cagacaggat      900

atgtgacaaa agttgctatg caattatggt tggcagcact gtaaccttta tagctggagt      960

ttatcaggta gcgatgggct tctttcaagt gggttttgtt tctgtctacc tctcagatgc     1020

cttgctgagt ggatttgtca ctggtgcctc cttcactatt cttacatctc aggccaagta     1080

tcttcttggg ctcaaccttc ctcggactaa tggtgtgggc tcactcatca ctacctggat     1140

acatgtcttc agaaacatcc ataagaccaa tctctgtgat cttatcacca gccttttgtg     1200

ccttttggtt cttttgccaa ccaaagaact caatgaacac ttcaaatcca agcttaaggc     1260

accgattcct attgaacttg ttgttgttgt agcagccaca ttagcctctc attttggaaa     1320

actacatgaa aattataatt ctagtattgc tggacatatt cccactgggt ttatgccacc     1380

caaagtacca gaatggaacc taattcctag tgtggctgta gatgcaatag ctatttccat     1440

cattggtttt gctatcactg tatcactttc tgagatgttt gccaagaaac atggttacac     1500

agtcaaagca aaccaggaaa tgtatgccat tggcttttgt aatatcatcc cttccttctt     1560

ccactgtttt actactagtg cagctcttgc aaagacattg gttaaagaat caacaggctg     1620

ccatactcag ctttctggtg tggtaacagc cctggttctt ttgttggtcc tcctagtaat     1680

agctcctttg ttctattccc ttcaaaaaag tgtccttggt gtgatcacaa ttgtaaatct     1740

acggggagcc cttcgtaaat ttagggatct tcccaaaatg tggagtatta gtagaatgga     1800

tacagttatc tggtttgtta ctatgctgtc ctctgcactg ctaagtactg aaataggcct     1860

acttgttggg gtttgttttt ctatattttg tgtcatcctc cgcactcaga agccaaagag     1920

ttcactgctt ggcttggtgg aagagtctga ggtctttgaa tctgtgtctg cttacaagaa     1980

ccttcagatt aagccaggca tcaagatttt ccgctttgta gcccctctct actacataaa     2040

caaagaatgc tttaaatctg ctttatacaa acaaactgtc aacccaatct taataaaggt     2100

ggcttggaag aaggcagcaa agagaaagat caaagaaaaa gtagtgactc ttggtggaat     2160

ccaggatgaa atgtcagtgc aactttccca tgatcccttg gagctgcata ctatagtgat     2220

tgactgcagt gcaattcaat ttttagatac agcagggatc cacacactga aagaagttcg     2280

cagagattat gaagccattg gaatccaggt tctgctggct cagtgcaatc ccactgtgag     2340

ggattcccta accaacggag aatattgcaa aaaggaagaa gaaaaccttc tcttctatag     2400

tgtgtatgaa gcgatggctt ttgcagaagt atctaaaaat cagaaaggag tatgtgttcc     2460

caatggtctg agtcttagta gtgattaatt gagaaggtag atagaagaat gtctagccaa     2520

taggttaaaa tttcaagtgt ccaacatttc ccagttccac agtgggaaat tttgcacact     2580

tgaaatttta accaagtggc tagatattat tcctcctttg aagctaatgg catttgtata     2640

tacacactgc agcagagctt gtagctggac agagtcaaaa agaagaaaat acggtttcag     2700

gctttcttgc agatatgaag tattcttgga atgcaataag tatgtattga actgtactgt     2760

aaagtagctc caaaacttaa ttactctcct gttttagggg ttatacattt ggactgtgca     2820

ttctccaaga gatgaagcgg tgaagttggg atttacattg gaagtgctgt agacttcttt     2880

atgtggctca gtggagagag ggaaagaatg ttgcacctgc tctagtacca taggtcaaga     2940

ggcttctgga tcacaaagtc ataactagac aggtttgttc ttgtagtttt ctatccccag     3000

tctttgctcc ccagatggca gtagttttta gtaggaaagt gccattcctg tccttaaggc     3060

acagtctcat cagaagtcta atacctgggc aggtttataa catcctgaga gccagcctga     3120

cattagacag aatacccttt gtaatacatt ggaaattttt actcatgcct ttttgtttag     3180

gataaatagg taagcacaaa gagctcttca aaatcagaaa aaacaatagg agtccttcct     3240

tgtcttttct gtgatctctg tccttgtttc tgagactttc tctaccatta agctctattt     3300

tagctttcag ttattctagt ttgtttccca tggaatctgt cctaaactgg tgtttttgtc     3360

agtgacagtc ttgccagtca gcaatttcta acagcatttt aaatgagttt gatgtacagt     3420

aaatattgat gacaatgaca gcttttaact cttcaagtca cctaaagcta ttatgcagga     3480

ggatttagaa gtcacattca taaaacccaa gtgctatggg tgtattattc atgatagctg     3540

gcccacaggt catgaattga ggaggaattt gctttcaaaa agcaagaatg tccaacactg     3600

aaagtttata gttttatatt tggaccttga aaggtaagaa aaaaccaggt tctccaaagt     3660

taggaatagg gaactaattt atgaaacagc catcttaaaa aaaaaaaaag taaactgcaa     3720

aagtacaaaa tcatttttca atctgttccc agtttctaaa caattttaaa tatttatgag     3780

aagcaaaccc tatgtgtagg gcatctgttg gagtgggatg cttttagaca tatattaagt     3840

atgtacatgt ttaatatgta tatttaaaat gcatatatat tttattatat ctatattatc     3900

ctatatagat atatgtaact tagctttatt gttagctcca taagctgcca gtgttgcttt     3960

tctgttggta gagctctccc atttggtgac atggaaaata cctttccatt atcacaacaa     4020

agcagttgct cagtagaaag tctagatttc tgtcttatag gtgatttctg tcttataggt     4080

gattataatc aagtgtaggc ttcctgaatt ttgacatcct tttagaactt gggtctggaa     4140

ttccagaaat gttaattgct gcttgtattt gttcttgttt gttttttagc cagtatttgc     4200

cctttctatc cagccttatg aataatagca gtaaaatcac agtatcttgg tcagtcttta     4260

tttttttcct tttttctttt ttaagagaca gtcatccagg ccagagtgca gtttgatgat     4320

agcttactga agcttcccac tcctgggctc aagttatcct tccattttgg cctcctgagt     4380

agctagacca taggtatgca tcaccacacc ctgctaattt tttaaatttt tttctagaga     4440

gagggtctca ctgtgttgcc caggctggtc tcaaactcca ggctcaagca atccttcagc     4500

ctcagcctcc cagagtgttg ggattacagg cgtgagccac tgcacttggc caagttattt     4560

atttttaatc tctcttgccc ttctcccaag gcaggcttaa gttgagacta ttataggtgt     4620

ctaataacct gtgacagagt aatgagtaca tgcttaagat gttataatta gccaacacca     4680

acacagcaaa aaatataatt ccagccaaag attctggaaa atccctcaga aggagggata     4740

acaggatttg acctttacca gcgatttctg tccatatgtg gatgtaaaca gttctggaac     4800

gttatgcatg cagttagcga atccttgaat tatgttctgg tttgtacttg tcccatccat     4860

ccaaacaaga gattctgctt ttggtagcca tctgtagaaa catttaagat gtcactagaa     4920

tttacatttc atcctctcta cttgggttga ggttgcctat acttgcatat tgttaaaatg     4980

ttttggttgc tgatattcag aggaatgaaa cctggaacca aagcctaatt tgccgataaa     5040

aaaactgttt tcggccaggt gcagtggctc atgcctgtaa tcccagcacg ttgggaggcc     5100

gaggcgggtg gatcacctga agtcaggagt tcgagaccat cctggctaac actgtgaaac     5160

cccgtctcta ctaaaaatac aaaaaattag cggggcatgg tggcacgcgc ctgtagtccc     5220

agctactcag gaggctgagg caggagaatt acttgaaccc gggaggcgga ggttgcagta     5280

agcagagatt gtgccactgg actccagcct gggtgacaga gcgagactcc gtctcaaaca     5340

aacaaacaaa aaactgtttt catttgctct cttgaccaaa ggataggact ttagttcttt     5400

aagcattatt ttaaacacta tattgataca aaaatatctt gcttactcta aactttagag     5460

tctaaatgaa gctttttctc agtacaagat tctgagtatc ataaaatggt tatttaattg     5520

aaacgtagtg tggtatactc ttgatggtta gaactcttac agccttattt atttttaagt     5580

ttgttacagc caaagggttg gagtgtgcca gtgcacaggt agactaagga aaacattata     5640

gaggagtgaa gagaacagac cattgaaaag actattatct gaccagcgga ggcagaaaag     5700

agaggaaccc agttgaatag gatccaatcc ctggttagcc tctacacaat aatagggaga     5760

caaggattag gagccatacc tcccagagca aggtatcttt ctagagcaaa tttctctttc     5820

tagaagggga gggtcacagg gtcacagatt caccaaagct gaaagggctg aggagctcat     5880

ggtagcctgg gctgacctac tctggagcac ggtgtcttcc ttctaaactg agtgactgta     5940

gtactatctg tgcctctgat ggtaataaaa ctgacaagat gtctaatttt tttttaagta     6000

ggaccaaagg aaaacaagat ttagatagtc tgactttgct tttgaacaac agacattgca     6060

agtcaaaatt gttgtcaaat ttacatatgg taaatgatga actttaaaaa tgtgtccagg     6120

tgttagatga gttcattaga ctcttttaat gctaatggct agtacgttta aacaaaacag     6180

cagttctctg ctgcaatatt cccattgacc acttaaatga ccataagtgg tcatttaaga     6240

acatgttagg gttagccctg atctgaatat aaaagtgaga aaagggctac agtgcatttc     6300

ttggtaactt aaactgagtc ttgaagttat aatgatccat tcgagttctg tgatccttat     6360

tgttcttaat tgtgtttctc tacgtattgt tacagatgag ccatacgttt ctttgtatca     6420

atgtagacat gacttcagat acctctgagg acctacccag cagtctagga ccctgggcca     6480

agtgctggga ctatggtact aaatccagta gatgggctgt gtagcaactc tcccagggaa     6540

cacactaggg tacttaggga ggtgctttgt ggagcatgtt gaagctttga gatctgagca     6600

ggaggcagtg atgtccctgg tctattcagg gaaagatttc agtgtgaaat ggtaaacatc     6660

caattgacag gatttagatt ttgcttagtt tttctgcttt ttaatgtttc tatcccccat     6720

ctcagtgttt tctttatcca tcccagtgat gccttatttg aaactgggct taaactgcaa     6780

aaagaatgaa gttggattta ggaagctgtt agatcattga gtggtgttga gagtgaagtt     6840

tcactagcag ggaagtttcc ttgagcctaa aataaaaaga aaaaattaaa aagaatcagt     6900

ttttttaatt aaaaaaatag aaagctgtta ggctcctaat tcgtggggtt tttttttgta     6960

aaaacagttt agataatcct gaatgcaatc attaacttgg ttgctaatta caagaatgaa     7020

aattataatg gaaaaggaca aaataatata ccagctggtt tgttattata gtccgtgtat     7080

taaaatacta ttgaaatacg ttaaaggtaa atttttaagg tttaaaaaaa atttagtaac     7140

ttacagggat ggagaattta gatgtcagag gtggggagat ttatttttat aaggtaattt     7200

ttatcctgat aaggacttaa aaaaaagttt tgcaactgaa attttaaagt aaacatgtta     7260

agtacagtta aaaagtaagc attgtagtaa atagtggatt ctctggtgtg tattttttat     7320

ctcagtgttg aaaattggaa aagaatggac tgaagtctaa aaactggaat aatgaaggac     7380

actaaatgcc tttattgtag atactatgtt tgtaagtcta tagctaagca acttaagcca     7440

aaaaggtctt tcaactgaag ctttaatcaa cttattttgg agatgttctc ttcccttatc     7500

tcatgcgtca tccctaaaat aataagatac atgggatcaa atagcccttg ccttttcaac     7560

acaaatcagt tggaaaatta tggtttgagt cctgttgctg ccatggcttc tgtttctcag     7620

aaatgagtgt gtatgaacat accaatctat gtaataggct accttttttt gtcttctttg     7680

gaactttgta cacaaaccaa gacaatatca gggtgacagg tgaatgaact taaattctca     7740

gtcttgtcta ttcaccaaaa aagtatactg cctgtttttt ctttaattat tcaaggttga     7800

tgacttttag gaacatgttt tatactgtat tttttaatta aagcaagtgc cttgatgtaa     7860

ttccatgtaa atcattgctt aaccctctta tgggatgagg atgagttatt aatgtattgc     7920

agcctactgg aaaggagggg gagttggtta atagcagata cttttcttct agaagcttat     7980

gttttatgct gtttattatg taagatcctg tatgtgtgtt gagatttaga ggtttcattt     8040

gttttgtctg ctaataaatt gttactctaa taataaaaaa aa                        8082


<210>  2
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ser Glu Ser Lys Glu Gln His Asn Val Ser Pro Arg Asp Ser 
1               5                   10                  15      


Ala Glu Gly Asn Asp Ser Tyr Pro Ser Gly Ile His Leu Glu Leu Gln 
            20                  25                  30          


Arg Glu Ser Ser Thr Asp Phe Lys Gln Phe Glu Thr Asn Asp Gln Cys 
        35                  40                  45              


Arg Pro Tyr His Arg Ile Leu Ile Glu Arg Gln Glu Lys Ser Asp Thr 
    50                  55                  60                  


Asn Phe Lys Glu Phe Val Ile Lys Lys Leu Gln Lys Asn Cys Gln Cys 
65                  70                  75                  80  


Ser Pro Ala Lys Ala Lys Asn Met Ile Leu Gly Phe Leu Pro Val Leu 
                85                  90                  95      


Gln Trp Leu Pro Lys Tyr Asp Leu Lys Lys Asn Ile Leu Gly Asp Val 
            100                 105                 110         


Met Ser Gly Leu Ile Val Gly Ile Leu Leu Val Pro Gln Ser Ile Ala 
        115                 120                 125             


Tyr Ser Leu Leu Ala Gly Gln Glu Pro Val Tyr Gly Leu Tyr Thr Ser 
    130                 135                 140                 


Phe Phe Ala Ser Ile Ile Tyr Phe Leu Leu Gly Thr Ser Arg His Ile 
145                 150                 155                 160 


Ser Val Gly Ile Phe Gly Val Leu Cys Leu Met Ile Gly Glu Thr Val 
                165                 170                 175     


Asp Arg Glu Leu Gln Lys Ala Gly Tyr Asp Asn Ala His Ser Ala Pro 
            180                 185                 190         


Ser Leu Gly Met Val Ser Asn Gly Ser Thr Leu Leu Asn His Thr Ser 
        195                 200                 205             


Asp Arg Ile Cys Asp Lys Ser Cys Tyr Ala Ile Met Val Gly Ser Thr 
    210                 215                 220                 


Val Thr Phe Ile Ala Gly Val Tyr Gln Val Ala Met Gly Phe Phe Gln 
225                 230                 235                 240 


Val Gly Phe Val Ser Val Tyr Leu Ser Asp Ala Leu Leu Ser Gly Phe 
                245                 250                 255     


Val Thr Gly Ala Ser Phe Thr Ile Leu Thr Ser Gln Ala Lys Tyr Leu 
            260                 265                 270         


Leu Gly Leu Asn Leu Pro Arg Thr Asn Gly Val Gly Ser Leu Ile Thr 
        275                 280                 285             


Thr Trp Ile His Val Phe Arg Asn Ile His Lys Thr Asn Leu Cys Asp 
    290                 295                 300                 


Leu Ile Thr Ser Leu Leu Cys Leu Leu Val Leu Leu Pro Thr Lys Glu 
305                 310                 315                 320 


Leu Asn Glu His Phe Lys Ser Lys Leu Lys Ala Pro Ile Pro Ile Glu 
                325                 330                 335     


Leu Val Val Val Val Ala Ala Thr Leu Ala Ser His Phe Gly Lys Leu 
            340                 345                 350         


His Glu Asn Tyr Asn Ser Ser Ile Ala Gly His Ile Pro Thr Gly Phe 
        355                 360                 365             


Met Pro Pro Lys Val Pro Glu Trp Asn Leu Ile Pro Ser Val Ala Val 
    370                 375                 380                 


Asp Ala Ile Ala Ile Ser Ile Ile Gly Phe Ala Ile Thr Val Ser Leu 
385                 390                 395                 400 


Ser Glu Met Phe Ala Lys Lys His Gly Tyr Thr Val Lys Ala Asn Gln 
                405                 410                 415     


Glu Met Tyr Ala Ile Gly Phe Cys Asn Ile Ile Pro Ser Phe Phe His 
            420                 425                 430         


Cys Phe Thr Thr Ser Ala Ala Leu Ala Lys Thr Leu Val Lys Glu Ser 
        435                 440                 445             


Thr Gly Cys His Thr Gln Leu Ser Gly Val Val Thr Ala Leu Val Leu 
    450                 455                 460                 


Leu Leu Val Leu Leu Val Ile Ala Pro Leu Phe Tyr Ser Leu Gln Lys 
465                 470                 475                 480 


Ser Val Leu Gly Val Ile Thr Ile Val Asn Leu Arg Gly Ala Leu Arg 
                485                 490                 495     


Lys Phe Arg Asp Leu Pro Lys Met Trp Ser Ile Ser Arg Met Asp Thr 
            500                 505                 510         


Val Ile Trp Phe Val Thr Met Leu Ser Ser Ala Leu Leu Ser Thr Glu 
        515                 520                 525             


Ile Gly Leu Leu Val Gly Val Cys Phe Ser Ile Phe Cys Val Ile Leu 
    530                 535                 540                 


Arg Thr Gln Lys Pro Lys Ser Ser Leu Leu Gly Leu Val Glu Glu Ser 
545                 550                 555                 560 


Glu Val Phe Glu Ser Val Ser Ala Tyr Lys Asn Leu Gln Ile Lys Pro 
                565                 570                 575     


Gly Ile Lys Ile Phe Arg Phe Val Ala Pro Leu Tyr Tyr Ile Asn Lys 
            580                 585                 590         


Glu Cys Phe Lys Ser Ala Leu Tyr Lys Gln Thr Val Asn Pro Ile Leu 
        595                 600                 605             


Ile Lys Val Ala Trp Lys Lys Ala Ala Lys Arg Lys Ile Lys Glu Lys 
    610                 615                 620                 


Val Val Thr Leu Gly Gly Ile Gln Asp Glu Met Ser Val Gln Leu Ser 
625                 630                 635                 640 


His Asp Pro Leu Glu Leu His Thr Ile Val Ile Asp Cys Ser Ala Ile 
                645                 650                 655     


Gln Phe Leu Asp Thr Ala Gly Ile His Thr Leu Lys Glu Val Arg Arg 
            660                 665                 670         


Asp Tyr Glu Ala Ile Gly Ile Gln Val Leu Leu Ala Gln Cys Asn Pro 
        675                 680                 685             


Thr Val Arg Asp Ser Leu Thr Asn Gly Glu Tyr Cys Lys Lys Glu Glu 
    690                 695                 700                 


Glu Asn Leu Leu Phe Tyr Ser Val Tyr Glu Ala Met Ala Phe Ala Glu 
705                 710                 715                 720 


Val Ser Lys Asn Gln Lys Gly Val Cys Val Pro Asn Gly Leu Ser Leu 
                725                 730                 735     


Ser Ser Asp 
            


