                         SEQUENCE LISTING

<110>  Blueprint Medicines Corporation
       SCHMIDT-KITTLER, Oleg
 
<120>  KIT MUTATIONS

<130>  134108-03320

<150>  62/758806
<151>  2018-11-12

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  385
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic nucleotide

<400>  1
gtaaagatgc tcaagcgtaa gttcctgtat ggtactgcat gcgcttgaca tcagtttgcc       60

agttgtgctt tttgctaaaa tgcatgtttc caattttagc gagtgcccat ttgacagaac      120

gggaagccct catgtctgaa ctcaaagtcc tgagttacct tggtaatcac atgaatattg      180

cgaatctact tggagcctgc accattggag gtaaagccgt gtccaagctg ccttttattg      240

tctgtcaggt tatcaaaaca tgacatttta atatgatttt ggcaatgcta gattataaac      300

tgcttggaag atttttttac ccagactgtt gttctctctt gctagatttt gttttcctca      360

ttgttcttaa gaatgcagat tttaa                                            385


<210>  2
<211>  384
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic nucleotide

<400>  2
taaagatgct caagcgtaag ttcctgtatg gtactgcatg cgcttgacat cagtttgcca       60

gttgtgcttt ttgctaaaat gcatgtttcc aattttagcg agtgcccatt tgacagaacg      120

ggaagccctc atgtctgaac tcaaagtcct gagttacctt ggtaatcaca tgaatattgt      180

gactctactt ggagcctgca ccattggagg taaagccgtg tccaagctgc cttttattgt      240

ctgtcaggtt atcaaaacat gacattttaa tatgattttg gcaatgctag attataaact      300

gcttggaaga tttttttacc cagactgttg ttctctcttg ctagattttg ttttcctcat      360

tgttcttaag aatgcagatt ttaa                                             384


<210>  3
<211>  385
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic nucleotide

<400>  3
ttttatgtta ctccacataa ggctgctttt ttgataagca gtgttaatat atgggattgt       60

attgggacta agtagtctga tccactgaag ctgaatatta atggccatga ccacccttgg      120

gtatttttat gggaggcaga attaatctat atatctcacc ttctttctaa ccttttctta      180

tgtgctttta gggcccaccc tggtcattat agaatattgt tgctatggtg atcttttgaa      240

ttttttgaga agaaaacgtg attcatttat ttgttcaaag caggaagatc atgcagaagc      300

tgcactttat aagaatcttc tgcattcaaa ggagtcttcc tggtaagact gatttacata      360

aatagttagc tgttgacagg cagtt                                            385


<210>  4
<211>  5190
<212>  DNA
<213>  Homo sapiens

<400>  4
tctgggggct cggctttgcc gcgctcgctg cacttgggcg agagctggaa cgtggaccag       60

agctcggatc ccatcgcagc taccgcgatg agaggcgctc gcggcgcctg ggattttctc      120

tgcgttctgc tcctactgct tcgcgtccag acaggctctt ctcaaccatc tgtgagtcca      180

ggggaaccgt ctccaccatc catccatcca ggaaaatcag acttaatagt ccgcgtgggc      240

gacgagatta ggctgttatg cactgatccg ggctttgtca aatggacttt tgagatcctg      300

gatgaaacga atgagaataa gcagaatgaa tggatcacgg aaaaggcaga agccaccaac      360

accggcaaat acacgtgcac caacaaacac ggcttaagca attccattta tgtgtttgtt      420

agagatcctg ccaagctttt ccttgttgac cgctccttgt atgggaaaga agacaacgac      480

acgctggtcc gctgtcctct cacagaccca gaagtgacca attattccct caaggggtgc      540

caggggaagc ctcttcccaa ggacttgagg tttattcctg accccaaggc gggcatcatg      600

atcaaaagtg tgaaacgcgc ctaccatcgg ctctgtctgc attgttctgt ggaccaggag      660

ggcaagtcag tgctgtcgga aaaattcatc ctgaaagtga ggccagcctt caaagctgtg      720

cctgttgtgt ctgtgtccaa agcaagctat cttcttaggg aaggggaaga attcacagtg      780

acgtgcacaa taaaagatgt gtctagttct gtgtactcaa cgtggaaaag agaaaacagt      840

cagactaaac tacaggagaa atataatagc tggcatcacg gtgacttcaa ttatgaacgt      900

caggcaacgt tgactatcag ttcagcgaga gttaatgatt ctggagtgtt catgtgttat      960

gccaataata cttttggatc agcaaatgtc acaacaacct tggaagtagt agataaagga     1020

ttcattaata tcttccccat gataaacact acagtatttg taaacgatgg agaaaatgta     1080

gatttgattg ttgaatatga agcattcccc aaacctgaac accagcagtg gatctatatg     1140

aacagaacct tcactgataa atgggaagat tatcccaagt ctgagaatga aagtaatatc     1200

agatacgtaa gtgaacttca tctaacgaga ttaaaaggca ccgaaggagg cacttacaca     1260

ttcctagtgt ccaattctga cgtcaatgct gccatagcat ttaatgttta tgtgaataca     1320

aaaccagaaa tcctgactta cgacaggctc gtgaatggca tgctccaatg tgtggcagca     1380

ggattcccag agcccacaat agattggtat ttttgtccag gaactgagca gagatgctct     1440

gcttctgtac tgccagtgga tgtgcagaca ctaaactcat ctgggccacc gtttggaaag     1500

ctagtggttc agagttctat agattctagt gcattcaagc acaatggcac ggttgaatgt     1560

aaggcttaca acgatgtggg caagacttct gcctatttta actttgcatt taaaggtaac     1620

aacaaagagc aaatccatcc ccacaccctg ttcactcctt tgctgattgg tttcgtaatc     1680

gtagctggca tgatgtgcat tattgtgatg attctgacct acaaatattt acagaaaccc     1740

atgtatgaag tacagtggaa ggttgttgag gagataaatg gaaacaatta tgtttacata     1800

gacccaacac aacttcctta tgatcacaaa tgggagtttc ccagaaacag gctgagtttt     1860

gggaaaaccc tgggtgctgg agctttcggg aaggttgttg aggcaactgc ttatggctta     1920

attaagtcag atgcggccat gactgtcgct gtaaagatgc tcaagccgag tgcccatttg     1980

acagaacggg aagccctcat gtctgaactc aaagtcctga gttaccttgg taatcacatg     2040

aatattgcga atctacttgg agcctgcacc attggagggc ccaccctggt cattacagaa     2100

tattgttgct atggtgatct tttgaatttt ttgagaagaa aacgtgattc atttatttgt     2160

tcaaagcagg aagatcatgc agaagctgca ctttataaga atcttctgca ttcaaaggag     2220

tcttcctgca gcgatagtac taatgagtac atggacatga aacctggagt ttcttatgtt     2280

gtcccaacca aggccgacaa aaggagatct gtgagaatag gctcatacat agaaagagat     2340

gtgactcccg ccatcatgga ggatgacgag ttggccctag acttagaaga cttgctgagc     2400

ttttcttacc aggtggcaaa gggcatggct ttcctcgcct ccaagaattg tattcacaga     2460

gacttggcag ccagaaatat cctccttact catggtcgga tcacaaagat ttgtgatttt     2520

ggtctagcca gagacatcaa gaatgattct aattatgtgg ttaaaggaaa cgctcgacta     2580

cctgtgaagt ggatggcacc tgaaagcatt ttcaactgtg tatacacgtt tgaaagtgac     2640

gtctggtcct atgggatttt tctttgggag ctgttctctt taggaagcag cccctatcct     2700

ggaatgccgg tcgattctaa gttctacaag atgatcaagg aaggcttccg gatgctcagc     2760

cctgaacacg cacctgctga aatgtatgac ataatgaaga cttgctggga tgcagatccc     2820

ctaaaaagac caacattcaa gcaaattgtt cagctaattg agaagcagat ttcagagagc     2880

accaatcata tttactccaa cttagcaaac tgcagcccca accgacagaa gcccgtggta     2940

gaccattctg tgcggatcaa ttctgtcggc agcaccgctt cctcctccca gcctctgctt     3000

gtgcacgacg atgtctgagc agaatcagtg tttgggtcac ccctccagga atgatctctt     3060

cttttggctt ccatgatggt tattttcttt tctttcaact tgcatccaac tccaggatag     3120

tgggcacccc actgcaatcc tgtctttctg agcacacttt agtggccgat gatttttgtc     3180

atcagccacc atcctattgc aaaggttcca actgtatata ttcccaatag caacgtagct     3240

tctaccatga acagaaaaca ttctgatttg gaaaaagaga gggaggtatg gactgggggc     3300

cagagtcctt tccaaggctt ctccaattct gcccaaaaat atggttgata gtttacctga     3360

ataaatggta gtaatcacag ttggccttca gaaccatcca tagtagtatg atgatacaag     3420

attagaagct gaaaacctaa gtcctttatg tggaaaacag aacatcatta gaacaaagga     3480

cagagtatga acacctgggc ttaagaaatc tagtatttca tgctgggaat gagacatagg     3540

ccatgaaaaa aatgatcccc aagtgtgaac aaaagatgct cttctgtgga ccactgcatg     3600

agcttttata ctaccgacct ggtttttaaa tagagtttgc tattagagca ttgaattgga     3660

gagaaggcct ccctagccag cacttgtata tacgcatcta taaattgtcc gtgttcatac     3720

atttgagggg aaaacaccat aaggtttcgt ttctgtatac aaccctggca ttatgtccac     3780

tgtgtataga agtagattaa gagccatata agtttgaagg aaacagttaa taccattttt     3840

taaggaaaca atataaccac aaagcacagt ttgaacaaaa tctcctcttt tagctgatga     3900

acttattctg tagattctgt ggaacaagcc tatcagcttc agaatggcat tgtactcaat     3960

ggatttgatg ctgtttgaca aagttactga ttcactgcat ggctcccaca ggagtgggaa     4020

aacactgcca tcttagtttg gattcttatg tagcaggaaa taaagtatag gtttagcctc     4080

cttcgcaggc atgtcctgga caccgggcca gtatctatat atgtgtatgt acgtttgtat     4140

gtgtgtagac aaatatttgg aggggtattt ttgccctgag tccaagaggg tcctttagta     4200

cctgaaaagt aacttggctt tcattattag tactgctctt gtttcttttc acatagctgt     4260

ctagagtagc ttaccagaag cttccatagt ggtgcagagg aagtggaagg catcagtccc     4320

tatgtatttg cagttcacct gcacttaagg cactctgtta tttagactca tcttactgta     4380

cctgttcctt agaccttcca taatgctact gtctcactga aacatttaaa ttttaccctt     4440

tagactgtag cctggatatt attcttgtag tttacctctt taaaaacaaa acaaaacaaa     4500

acaaaaaact ccccttcctc actgcccaat ataaaaggca aatgtgtaca tggcagagtt     4560

tgtgtgttgt cttgaaagat tcaggtatgt tgcctttatg gtttccccct tctacatttc     4620

ttagactaca tttagagaac tgtggccgtt atctggaagt aaccatttgc actggagttc     4680

tatgctctcg cacctttcca aagttaacag attttggggt tgtgttgtca cccaagagat     4740

tgttgtttgc catactttgt ctgaaaaatt cctttgtgtt tctattgact tcaatgatag     4800

taagaaaagt ggttgttagt tatagatgtc taggtacttc aggggcactt cattgagagt     4860

tttgtcttgg atattcttga aagtttatat ttttataatt ttttcttaca tcagatgttt     4920

ctttgcagtg gcttaatgtt tgaaattatt ttgtggcttt ttttgtaaat attgaaatgt     4980

agcaataatg tcttttgaat attcccaagc ccatgagtcc ttgaaaatat tttttatata     5040

tacagtaact ttatgtgtaa atacataagc ggcgtaagtt taaaggatgt tggtgttcca     5100

cgtgttttat tcctgtatgt tgtccaattg ttgacagttc tgaagaattc taataaaatg     5160

tacatatata aatcaaaaaa aaaaaaaaaa                                      5190


<210>  5
<211>  5190
<212>  DNA
<213>  Homo sapiens

<400>  5
tctgggggct cggctttgcc gcgctcgctg cacttgggcg agagctggaa cgtggaccag       60

agctcggatc ccatcgcagc taccgcgatg agaggcgctc gcggcgcctg ggattttctc      120

tgcgttctgc tcctactgct tcgcgtccag acaggctctt ctcaaccatc tgtgagtcca      180

ggggaaccgt ctccaccatc catccatcca ggaaaatcag acttaatagt ccgcgtgggc      240

gacgagatta ggctgttatg cactgatccg ggctttgtca aatggacttt tgagatcctg      300

gatgaaacga atgagaataa gcagaatgaa tggatcacgg aaaaggcaga agccaccaac      360

accggcaaat acacgtgcac caacaaacac ggcttaagca attccattta tgtgtttgtt      420

agagatcctg ccaagctttt ccttgttgac cgctccttgt atgggaaaga agacaacgac      480

acgctggtcc gctgtcctct cacagaccca gaagtgacca attattccct caaggggtgc      540

caggggaagc ctcttcccaa ggacttgagg tttattcctg accccaaggc gggcatcatg      600

atcaaaagtg tgaaacgcgc ctaccatcgg ctctgtctgc attgttctgt ggaccaggag      660

ggcaagtcag tgctgtcgga aaaattcatc ctgaaagtga ggccagcctt caaagctgtg      720

cctgttgtgt ctgtgtccaa agcaagctat cttcttaggg aaggggaaga attcacagtg      780

acgtgcacaa taaaagatgt gtctagttct gtgtactcaa cgtggaaaag agaaaacagt      840

cagactaaac tacaggagaa atataatagc tggcatcacg gtgacttcaa ttatgaacgt      900

caggcaacgt tgactatcag ttcagcgaga gttaatgatt ctggagtgtt catgtgttat      960

gccaataata cttttggatc agcaaatgtc acaacaacct tggaagtagt agataaagga     1020

ttcattaata tcttccccat gataaacact acagtatttg taaacgatgg agaaaatgta     1080

gatttgattg ttgaatatga agcattcccc aaacctgaac accagcagtg gatctatatg     1140

aacagaacct tcactgataa atgggaagat tatcccaagt ctgagaatga aagtaatatc     1200

agatacgtaa gtgaacttca tctaacgaga ttaaaaggca ccgaaggagg cacttacaca     1260

ttcctagtgt ccaattctga cgtcaatgct gccatagcat ttaatgttta tgtgaataca     1320

aaaccagaaa tcctgactta cgacaggctc gtgaatggca tgctccaatg tgtggcagca     1380

ggattcccag agcccacaat agattggtat ttttgtccag gaactgagca gagatgctct     1440

gcttctgtac tgccagtgga tgtgcagaca ctaaactcat ctgggccacc gtttggaaag     1500

ctagtggttc agagttctat agattctagt gcattcaagc acaatggcac ggttgaatgt     1560

aaggcttaca acgatgtggg caagacttct gcctatttta actttgcatt taaaggtaac     1620

aacaaagagc aaatccatcc ccacaccctg ttcactcctt tgctgattgg tttcgtaatc     1680

gtagctggca tgatgtgcat tattgtgatg attctgacct acaaatattt acagaaaccc     1740

atgtatgaag tacagtggaa ggttgttgag gagataaatg gaaacaatta tgtttacata     1800

gacccaacac aacttcctta tgatcacaaa tgggagtttc ccagaaacag gctgagtttt     1860

gggaaaaccc tgggtgctgg agctttcggg aaggttgttg aggcaactgc ttatggctta     1920

attaagtcag atgcggccat gactgtcgct gtaaagatgc tcaagccgag tgcccatttg     1980

acagaacggg aagccctcat gtctgaactc aaagtcctga gttaccttgg taatcacatg     2040

aatattgtga ctctacttgg agcctgcacc attggagggc ccaccctggt cattacagaa     2100

tattgttgct atggtgatct tttgaatttt ttgagaagaa aacgtgattc atttatttgt     2160

tcaaagcagg aagatcatgc agaagctgca ctttataaga atcttctgca ttcaaaggag     2220

tcttcctgca gcgatagtac taatgagtac atggacatga aacctggagt ttcttatgtt     2280

gtcccaacca aggccgacaa aaggagatct gtgagaatag gctcatacat agaaagagat     2340

gtgactcccg ccatcatgga ggatgacgag ttggccctag acttagaaga cttgctgagc     2400

ttttcttacc aggtggcaaa gggcatggct ttcctcgcct ccaagaattg tattcacaga     2460

gacttggcag ccagaaatat cctccttact catggtcgga tcacaaagat ttgtgatttt     2520

ggtctagcca gagacatcaa gaatgattct aattatgtgg ttaaaggaaa cgctcgacta     2580

cctgtgaagt ggatggcacc tgaaagcatt ttcaactgtg tatacacgtt tgaaagtgac     2640

gtctggtcct atgggatttt tctttgggag ctgttctctt taggaagcag cccctatcct     2700

ggaatgccgg tcgattctaa gttctacaag atgatcaagg aaggcttccg gatgctcagc     2760

cctgaacacg cacctgctga aatgtatgac ataatgaaga cttgctggga tgcagatccc     2820

ctaaaaagac caacattcaa gcaaattgtt cagctaattg agaagcagat ttcagagagc     2880

accaatcata tttactccaa cttagcaaac tgcagcccca accgacagaa gcccgtggta     2940

gaccattctg tgcggatcaa ttctgtcggc agcaccgctt cctcctccca gcctctgctt     3000

gtgcacgacg atgtctgagc agaatcagtg tttgggtcac ccctccagga atgatctctt     3060

cttttggctt ccatgatggt tattttcttt tctttcaact tgcatccaac tccaggatag     3120

tgggcacccc actgcaatcc tgtctttctg agcacacttt agtggccgat gatttttgtc     3180

atcagccacc atcctattgc aaaggttcca actgtatata ttcccaatag caacgtagct     3240

tctaccatga acagaaaaca ttctgatttg gaaaaagaga gggaggtatg gactgggggc     3300

cagagtcctt tccaaggctt ctccaattct gcccaaaaat atggttgata gtttacctga     3360

ataaatggta gtaatcacag ttggccttca gaaccatcca tagtagtatg atgatacaag     3420

attagaagct gaaaacctaa gtcctttatg tggaaaacag aacatcatta gaacaaagga     3480

cagagtatga acacctgggc ttaagaaatc tagtatttca tgctgggaat gagacatagg     3540

ccatgaaaaa aatgatcccc aagtgtgaac aaaagatgct cttctgtgga ccactgcatg     3600

agcttttata ctaccgacct ggtttttaaa tagagtttgc tattagagca ttgaattgga     3660

gagaaggcct ccctagccag cacttgtata tacgcatcta taaattgtcc gtgttcatac     3720

atttgagggg aaaacaccat aaggtttcgt ttctgtatac aaccctggca ttatgtccac     3780

tgtgtataga agtagattaa gagccatata agtttgaagg aaacagttaa taccattttt     3840

taaggaaaca atataaccac aaagcacagt ttgaacaaaa tctcctcttt tagctgatga     3900

acttattctg tagattctgt ggaacaagcc tatcagcttc agaatggcat tgtactcaat     3960

ggatttgatg ctgtttgaca aagttactga ttcactgcat ggctcccaca ggagtgggaa     4020

aacactgcca tcttagtttg gattcttatg tagcaggaaa taaagtatag gtttagcctc     4080

cttcgcaggc atgtcctgga caccgggcca gtatctatat atgtgtatgt acgtttgtat     4140

gtgtgtagac aaatatttgg aggggtattt ttgccctgag tccaagaggg tcctttagta     4200

cctgaaaagt aacttggctt tcattattag tactgctctt gtttcttttc acatagctgt     4260

ctagagtagc ttaccagaag cttccatagt ggtgcagagg aagtggaagg catcagtccc     4320

tatgtatttg cagttcacct gcacttaagg cactctgtta tttagactca tcttactgta     4380

cctgttcctt agaccttcca taatgctact gtctcactga aacatttaaa ttttaccctt     4440

tagactgtag cctggatatt attcttgtag tttacctctt taaaaacaaa acaaaacaaa     4500

acaaaaaact ccccttcctc actgcccaat ataaaaggca aatgtgtaca tggcagagtt     4560

tgtgtgttgt cttgaaagat tcaggtatgt tgcctttatg gtttccccct tctacatttc     4620

ttagactaca tttagagaac tgtggccgtt atctggaagt aaccatttgc actggagttc     4680

tatgctctcg cacctttcca aagttaacag attttggggt tgtgttgtca cccaagagat     4740

tgttgtttgc catactttgt ctgaaaaatt cctttgtgtt tctattgact tcaatgatag     4800

taagaaaagt ggttgttagt tatagatgtc taggtacttc aggggcactt cattgagagt     4860

tttgtcttgg atattcttga aagtttatat ttttataatt ttttcttaca tcagatgttt     4920

ctttgcagtg gcttaatgtt tgaaattatt ttgtggcttt ttttgtaaat attgaaatgt     4980

agcaataatg tcttttgaat attcccaagc ccatgagtcc ttgaaaatat tttttatata     5040

tacagtaact ttatgtgtaa atacataagc ggcgtaagtt taaaggatgt tggtgttcca     5100

cgtgttttat tcctgtatgt tgtccaattg ttgacagttc tgaagaattc taataaaatg     5160

tacatatata aatcaaaaaa aaaaaaaaaa                                      5190


<210>  6
<211>  5190
<212>  DNA
<213>  Homo sapiens

<400>  6
tctgggggct cggctttgcc gcgctcgctg cacttgggcg agagctggaa cgtggaccag       60

agctcggatc ccatcgcagc taccgcgatg agaggcgctc gcggcgcctg ggattttctc      120

tgcgttctgc tcctactgct tcgcgtccag acaggctctt ctcaaccatc tgtgagtcca      180

ggggaaccgt ctccaccatc catccatcca ggaaaatcag acttaatagt ccgcgtgggc      240

gacgagatta ggctgttatg cactgatccg ggctttgtca aatggacttt tgagatcctg      300

gatgaaacga atgagaataa gcagaatgaa tggatcacgg aaaaggcaga agccaccaac      360

accggcaaat acacgtgcac caacaaacac ggcttaagca attccattta tgtgtttgtt      420

agagatcctg ccaagctttt ccttgttgac cgctccttgt atgggaaaga agacaacgac      480

acgctggtcc gctgtcctct cacagaccca gaagtgacca attattccct caaggggtgc      540

caggggaagc ctcttcccaa ggacttgagg tttattcctg accccaaggc gggcatcatg      600

atcaaaagtg tgaaacgcgc ctaccatcgg ctctgtctgc attgttctgt ggaccaggag      660

ggcaagtcag tgctgtcgga aaaattcatc ctgaaagtga ggccagcctt caaagctgtg      720

cctgttgtgt ctgtgtccaa agcaagctat cttcttaggg aaggggaaga attcacagtg      780

acgtgcacaa taaaagatgt gtctagttct gtgtactcaa cgtggaaaag agaaaacagt      840

cagactaaac tacaggagaa atataatagc tggcatcacg gtgacttcaa ttatgaacgt      900

caggcaacgt tgactatcag ttcagcgaga gttaatgatt ctggagtgtt catgtgttat      960

gccaataata cttttggatc agcaaatgtc acaacaacct tggaagtagt agataaagga     1020

ttcattaata tcttccccat gataaacact acagtatttg taaacgatgg agaaaatgta     1080

gatttgattg ttgaatatga agcattcccc aaacctgaac accagcagtg gatctatatg     1140

aacagaacct tcactgataa atgggaagat tatcccaagt ctgagaatga aagtaatatc     1200

agatacgtaa gtgaacttca tctaacgaga ttaaaaggca ccgaaggagg cacttacaca     1260

ttcctagtgt ccaattctga cgtcaatgct gccatagcat ttaatgttta tgtgaataca     1320

aaaccagaaa tcctgactta cgacaggctc gtgaatggca tgctccaatg tgtggcagca     1380

ggattcccag agcccacaat agattggtat ttttgtccag gaactgagca gagatgctct     1440

gcttctgtac tgccagtgga tgtgcagaca ctaaactcat ctgggccacc gtttggaaag     1500

ctagtggttc agagttctat agattctagt gcattcaagc acaatggcac ggttgaatgt     1560

aaggcttaca acgatgtggg caagacttct gcctatttta actttgcatt taaaggtaac     1620

aacaaagagc aaatccatcc ccacaccctg ttcactcctt tgctgattgg tttcgtaatc     1680

gtagctggca tgatgtgcat tattgtgatg attctgacct acaaatattt acagaaaccc     1740

atgtatgaag tacagtggaa ggttgttgag gagataaatg gaaacaatta tgtttacata     1800

gacccaacac aacttcctta tgatcacaaa tgggagtttc ccagaaacag gctgagtttt     1860

gggaaaaccc tgggtgctgg agctttcggg aaggttgttg aggcaactgc ttatggctta     1920

attaagtcag atgcggccat gactgtcgct gtaaagatgc tcaagccgag tgcccatttg     1980

acagaacggg aagccctcat gtctgaactc aaagtcctga gttaccttgg taatcacatg     2040

aatattgtga atctacttgg agcctgcacc attggagggc ccaccctggt cattatagaa     2100

tattgttgct atggtgatct tttgaatttt ttgagaagaa aacgtgattc atttatttgt     2160

tcaaagcagg aagatcatgc agaagctgca ctttataaga atcttctgca ttcaaaggag     2220

tcttcctgca gcgatagtac taatgagtac atggacatga aacctggagt ttcttatgtt     2280

gtcccaacca aggccgacaa aaggagatct gtgagaatag gctcatacat agaaagagat     2340

gtgactcccg ccatcatgga ggatgacgag ttggccctag acttagaaga cttgctgagc     2400

ttttcttacc aggtggcaaa gggcatggct ttcctcgcct ccaagaattg tattcacaga     2460

gacttggcag ccagaaatat cctccttact catggtcgga tcacaaagat ttgtgatttt     2520

ggtctagcca gagacatcaa gaatgattct aattatgtgg ttaaaggaaa cgctcgacta     2580

cctgtgaagt ggatggcacc tgaaagcatt ttcaactgtg tatacacgtt tgaaagtgac     2640

gtctggtcct atgggatttt tctttgggag ctgttctctt taggaagcag cccctatcct     2700

ggaatgccgg tcgattctaa gttctacaag atgatcaagg aaggcttccg gatgctcagc     2760

cctgaacacg cacctgctga aatgtatgac ataatgaaga cttgctggga tgcagatccc     2820

ctaaaaagac caacattcaa gcaaattgtt cagctaattg agaagcagat ttcagagagc     2880

accaatcata tttactccaa cttagcaaac tgcagcccca accgacagaa gcccgtggta     2940

gaccattctg tgcggatcaa ttctgtcggc agcaccgctt cctcctccca gcctctgctt     3000

gtgcacgacg atgtctgagc agaatcagtg tttgggtcac ccctccagga atgatctctt     3060

cttttggctt ccatgatggt tattttcttt tctttcaact tgcatccaac tccaggatag     3120

tgggcacccc actgcaatcc tgtctttctg agcacacttt agtggccgat gatttttgtc     3180

atcagccacc atcctattgc aaaggttcca actgtatata ttcccaatag caacgtagct     3240

tctaccatga acagaaaaca ttctgatttg gaaaaagaga gggaggtatg gactgggggc     3300

cagagtcctt tccaaggctt ctccaattct gcccaaaaat atggttgata gtttacctga     3360

ataaatggta gtaatcacag ttggccttca gaaccatcca tagtagtatg atgatacaag     3420

attagaagct gaaaacctaa gtcctttatg tggaaaacag aacatcatta gaacaaagga     3480

cagagtatga acacctgggc ttaagaaatc tagtatttca tgctgggaat gagacatagg     3540

ccatgaaaaa aatgatcccc aagtgtgaac aaaagatgct cttctgtgga ccactgcatg     3600

agcttttata ctaccgacct ggtttttaaa tagagtttgc tattagagca ttgaattgga     3660

gagaaggcct ccctagccag cacttgtata tacgcatcta taaattgtcc gtgttcatac     3720

atttgagggg aaaacaccat aaggtttcgt ttctgtatac aaccctggca ttatgtccac     3780

tgtgtataga agtagattaa gagccatata agtttgaagg aaacagttaa taccattttt     3840

taaggaaaca atataaccac aaagcacagt ttgaacaaaa tctcctcttt tagctgatga     3900

acttattctg tagattctgt ggaacaagcc tatcagcttc agaatggcat tgtactcaat     3960

ggatttgatg ctgtttgaca aagttactga ttcactgcat ggctcccaca ggagtgggaa     4020

aacactgcca tcttagtttg gattcttatg tagcaggaaa taaagtatag gtttagcctc     4080

cttcgcaggc atgtcctgga caccgggcca gtatctatat atgtgtatgt acgtttgtat     4140

gtgtgtagac aaatatttgg aggggtattt ttgccctgag tccaagaggg tcctttagta     4200

cctgaaaagt aacttggctt tcattattag tactgctctt gtttcttttc acatagctgt     4260

ctagagtagc ttaccagaag cttccatagt ggtgcagagg aagtggaagg catcagtccc     4320

tatgtatttg cagttcacct gcacttaagg cactctgtta tttagactca tcttactgta     4380

cctgttcctt agaccttcca taatgctact gtctcactga aacatttaaa ttttaccctt     4440

tagactgtag cctggatatt attcttgtag tttacctctt taaaaacaaa acaaaacaaa     4500

acaaaaaact ccccttcctc actgcccaat ataaaaggca aatgtgtaca tggcagagtt     4560

tgtgtgttgt cttgaaagat tcaggtatgt tgcctttatg gtttccccct tctacatttc     4620

ttagactaca tttagagaac tgtggccgtt atctggaagt aaccatttgc actggagttc     4680

tatgctctcg cacctttcca aagttaacag attttggggt tgtgttgtca cccaagagat     4740

tgttgtttgc catactttgt ctgaaaaatt cctttgtgtt tctattgact tcaatgatag     4800

taagaaaagt ggttgttagt tatagatgtc taggtacttc aggggcactt cattgagagt     4860

tttgtcttgg atattcttga aagtttatat ttttataatt ttttcttaca tcagatgttt     4920

ctttgcagtg gcttaatgtt tgaaattatt ttgtggcttt ttttgtaaat attgaaatgt     4980

agcaataatg tcttttgaat attcccaagc ccatgagtcc ttgaaaatat tttttatata     5040

tacagtaact ttatgtgtaa atacataagc ggcgtaagtt taaaggatgt tggtgttcca     5100

cgtgttttat tcctgtatgt tgtccaattg ttgacagttc tgaagaattc taataaaatg     5160

tacatatata aatcaaaaaa aaaaaaaaaa                                      5190


<210>  7
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Ala Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  8
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Thr Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  9
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Ile Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


