                         SEQUENCE LISTING

<110>  THE JOHNS HOPKINS UNIVERSITY
 
<120>  RASOPATHY TREATMENT

<130>  JHU-37180.601

<150>  US 62/751,968
<151>  2018-10-29

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  12381
<212>  DNA
<213>  Homo sapiens

<400>  1
aatctctagc tcgctcgcgc tccctctccc cgggccgtgg aaaggatccc acttccggtg       60

gggtgtcatg gcggcgtctc ggactgtgat ggctgtgggg agacggcgct agtggggaga      120

gcgaccaaga ggccccctcc cctccccggg tccccttccc ctatccccct ccccccagcc      180

tccttgccaa cgcccccttt ccctctcccc ctcccgctcg gcgctgaccc cccatcccca      240

cccccgtggg aacactggga gcctgcactc cacagaccct ctccttgcct cttccctcac      300

ctcagcctcc gctccccgcc ctcttcccgg cccagggcgc cggcccaccc ttccctccgc      360

cgccccccgg ccgcggggag gacatggccg cgcacaggcc ggtggaatgg gtccaggccg      420

tggtcagccg cttcgacgag cagcttccaa taaaaacagg acagcagaac acacatacca      480

aagtcagtac tgagcacaac aaggaatgtc taatcaatat ttccaaatac aagttttctt      540

tggttataag cggcctcact actattttaa agaatgttaa caatatgaga atatttggag      600

aagctgctga aaaaaattta tatctctctc agttgattat attggataca ctggaaaaat      660

gtcttgctgg gcaaccaaag gacacaatga gattagatga aacgatgctg gtcaaacagt      720

tgctgccaga aatctgccat tttcttcaca cctgtcgtga aggaaaccag catgcagctg      780

aacttcggaa ttctgcctct ggggttttat tttctctcag ctgcaacaac ttcaatgcag      840

tctttagtcg catttctacc aggttacagg aattaactgt ttgttcagaa gacaatgttg      900

atgttcatga tatagaattg ttacagtata tcaatgtgga ttgtgcaaaa ttaaaacgac      960

tcctgaagga aacagcattt aaatttaaag ccctaaagaa ggttgcgcag ttagcagtta     1020

taaatagcct ggaaaaggca ttttggaact gggtagaaaa ttatccagat gaatttacaa     1080

aactgtacca gatcccacag actgatatgg ctgaatgtgc agaaaagcta tttgacttgg     1140

tggatggttt tgctgaaagc accaaacgta aagcagcagt ttggccacta caaatcattc     1200

tccttatctt gtgtccagaa ataatccagg atatatccaa agacgtggtt gatgaaaaca     1260

acatgaataa gaagttattt ctggacagtc tacgaaaagc tcttgctggc catggaggaa     1320

gtaggcagct gacagaaagt gctgcaattg cctgtgtcaa actgtgtaaa gcaagtactt     1380

acatcaattg ggaagataac tctgtcattt tcctacttgt tcagtccatg gtggttgatc     1440

ttaagaacct gctttttaat ccaagtaagc cattctcaag aggcagtcag cctgcagatg     1500

tggatctaat gattgactgc cttgtttctt gctttcgtat aagccctcac aacaaccaac     1560

actttaagat ctgcctggct cagaattcac cttctacatt tcactatgtg ctggtaaatt     1620

cactccatcg aatcatcacc aattccgcat tggattggtg gcctaagatt gatgctgtgt     1680

attgtcactc ggttgaactt cgaaatatgt ttggtgaaac acttcataaa gcagtgcaag     1740

gttgtggagc acacccagca atacgaatgg caccgagtct tacatttaaa gaaaaagtaa     1800

caagccttaa atttaaagaa aaacctacag acctggagac aagaagctat aagtatcttc     1860

tcttgtccat ggtgaaacta attcatgcag atccaaagct cttgctttgt aatccaagaa     1920

aacaggggcc cgaaacccaa ggcagtacag cagaattaat tacagggctc gtccaactgg     1980

tccctcagtc acacatgcca gagattgctc aggaagcaat ggaggctctg ctggttcttc     2040

atcagttaga tagcattgat ttgtggaatc ctgatgctcc tgtagaaaca ttttgggaga     2100

ttagctcaca aatgcttttt tacatctgca agaaattaac tagtcatcaa atgcttagta     2160

gcacagaaat tctcaagtgg ttgcgggaaa tattgatctg caggaataaa tttcttctta     2220

aaaataagca ggcagataga agttcctgtc actttctcct tttttacggg gtaggatgtg     2280

atattccttc tagtggaaat accagtcaaa tgtccatgga tcatgaagaa ttactacgta     2340

ctcctggagc ctctctccgg aagggaaaag ggaactcctc tatggatagt gcagcaggat     2400

gcagcggaac ccccccgatt tgccgacaag cccagaccaa actagaagtg gccctgtaca     2460

tgtttctgtg gaaccctgac actgaagctg ttctggttgc catgtcctgt ttccgccacc     2520

tctgtgagga agcagatatc cggtgtgggg tggatgaagt gtcagtgcat aacctcttgc     2580

ccaactataa cacattcatg gagtttgcct ctgtcagcaa tatgatgtca acaggaagag     2640

cagcacttca gaaaagagtg atggcactgc tgaggcgcat tgagcatccc actgcaggaa     2700

acactgaggc ttgggaagat acacatgcaa aatgggaaca agcaacaaag ctaatcctta     2760

actatccaaa agccaaaatg gaagatggcc aggctgctga aagccttcac aagaccattg     2820

ttaagaggcg aatgtcccat gtgagtggag gaggatccat agatttgtct gacacagact     2880

ccctacagga atggatcaac atgactggct tcctttgtgc ccttggggga gtgtgcctcc     2940

agcagagaag caattctggc ctggcaacct atagcccacc catgggtcca gtcagtgaac     3000

gtaagggttc tatgatttca gtgatgtctt cagagggaaa cgcagataca cctgtcagca     3060

aatttatgga tcggctgttg tccttaatgg tgtgtaacca tgagaaagtg ggacttcaaa     3120

tacggaccaa tgttaaggat ctggtgggtc tagaattgag tcctgctctg tatccaatgc     3180

tatttaacaa attgaagaat accatcagca agttttttga ctcccaagga caggttttat     3240

tgactgatac caatactcaa tttgtagaac aaaccatagc tataatgaag aacttgctag     3300

ataatcatac tgaaggcagc tctgaacatc tagggcaagc tagcattgaa acaatgatgt     3360

taaatctggt caggtatgtt cgtgtgcttg ggaatatggt ccatgcaatt caaataaaaa     3420

cgaaactgtg tcaattagtt gaagtaatga tggcaaggag agatgacctc tcattttgcc     3480

aagagatgaa atttaggaat aagatggtag aatacctgac agactgggtt atgggaacat     3540

caaaccaagc agcagatgat gatgtaaaat gtcttacaag agatttggac caggcaagca     3600

tggaagcagt agtttcactt ctagctggtc tccctctgca gcctgaagaa ggagatggtg     3660

tggaattgat ggaagccaaa tcacagttat ttcttaaata cttcacatta tttatgaacc     3720

ttttgaatga ctgcagtgaa gttgaagatg aaagtgcgca aacaggtggc aggaaacgtg     3780

gcatgtctcg gaggctggca tcactgaggc actgtacggt ccttgcaatg tcaaacttac     3840

tcaatgccaa cgtagacagt ggtctcatgc actccatagg cttaggttac cacaaggatc     3900

tccagacaag agctacattt atggaagttc tgacaaaaat ccttcaacaa ggcacagaat     3960

ttgacacact tgcagaaaca gtattggctg atcggtttga gagattggtg gaactggtca     4020

caatgatggg tgatcaagga gaactcccta tagcgatggc tctggccaat gtggttcctt     4080

gttctcagtg ggatgaacta gctcgagttc tggttactct gtttgattct cggcatttac     4140

tctaccaact gctctggaac atgttttcta aagaagtaga attggcagac tccatgcaga     4200

ctctcttccg aggcaacagc ttggccagta aaataatgac attctgtttc aaggtatatg     4260

gtgctaccta tctacaaaaa ctcctggatc ctttattacg aattgtgatc acatcctctg     4320

attggcaaca tgttagcttt gaagtggatc ctaccaggtt agaaccatca gagagccttg     4380

aggaaaacca gcggaacctc cttcagatga ctgaaaagtt cttccatgcc atcatcagtt     4440

cctcctcaga attcccccct caacttcgaa gtgtgtgcca ctgtttatac caggtggtta     4500

gccagcgttt ccctcagaac agcatcggtg cagtaggaag tgccatgttc ctcagattta     4560

tcaatcctgc cattgtctca ccgtatgaag cagggatttt agataaaaag ccaccaccta     4620

gaatcgaaag gggcttgaag ttaatgtcaa agatacttca gagtattgcc aatcatgttc     4680

tcttcacaaa agaagaacat atgcggcctt tcaatgattt tgtgaaaagc aactttgatg     4740

cagcacgcag gtttttcctt gatatagcat ctgattgtcc tacaagtgat gcagtaaatc     4800

atagtctttc cttcataagt gacggcaatg tgcttgcttt acatcgtcta ctctggaaca     4860

atcaggagaa aattgggcag tatctttcca gcaacaggga tcataaagct gttggaagac     4920

gaccttttga taagatggca acacttcttg catacctggg tcctccagag cacaaacctg     4980

tggcagatac acactggtcc agccttaacc ttaccagttc aaagtttgag gaatttatga     5040

ctaggcatca ggtacatgaa aaagaagaat tcaaggcttt gaaaacgtta agtattttct     5100

accaagctgg gacttccaaa gctgggaatc ctatttttta ttatgttgca cggaggttca     5160

aaactggtca aatcaatggt gatttgctga tataccatgt cttactgact ttaaagccat     5220

attatgcaaa gccatatgaa attgtagtgg accttaccca taccgggcct agcaatcgct     5280

ttaaaacaga ctttctctct aagtggtttg ttgtttttcc tggctttgct tacgacaacg     5340

tctccgcagt ctatatctat aactgtaact cctgggtcag ggagtacacc aagtatcatg     5400

agcggctgct gactggcctc aaaggtagca aaaggcttgt tttcatagac tgtcctggga     5460

aactggctga gcacatagag catgaacaac agaaactacc tgctgccacc ttggctttag     5520

aagaggacct gaaggtattc cacaatgctc tcaagctagc tcacaaagac accaaagttt     5580

ctattaaagt tggttctact gctgtccaag taacttcagc agagcgaaca aaagtcctag     5640

ggcaatcagt ctttctaaat gacatttatt atgcttcgga aattgaagaa atctgcctag     5700

tagatgagaa ccagttcacc ttaaccattg caaaccaggg cacgccgctc accttcatgc     5760

accaggagtg tgaagccatt gtccagtcta tcattcatat ccggacccgc tgggaactgt     5820

cacagcccga ctctatcccc caacacacca agattcggcc aaaagatgtc cctgggacac     5880

tgctcaatat cgcattactt aatttaggca gttctgaccc gagtttacgg tcagctgcct     5940

ataatcttct gtgtgcctta acttgtacct ttaatttaaa aatcgagggc cagttactag     6000

agacatcagg tttatgtatc cctgccaaca acaccctctt tattgtctct attagtaaga     6060

cactggcagc caatgagcca cacctcacgt tagaattttt ggaagagtgt atttctggat     6120

ttagcaaatc tagtattgaa ttgaaacacc tttgtttgga atacatgact ccatggctgt     6180

caaatctagt tcgtttttgc aagcataatg atgatgccaa acgacaaaga gttactgcta     6240

ttcttgacaa gctgataaca atgaccatca atgaaaaaca gatgtaccca tctattcaag     6300

caaaaatatg gggaagcctt gggcagatta cagatctgct tgatgttgta ctagacagtt     6360

tcatcaaaac cagtgcaaca ggtggcttgg gatcaataaa agctgaggtg atggcagata     6420

ctgctgtagc tttggcttct ggaaatgtga aattggtttc aagcaaggtt attggaagga     6480

tgtgcaaaat aattgacaag acatgcttat ctccaactcc tactttagaa caacatctta     6540

tgtgggatga tattgctatt ttagcacgct acatgctgat gctgtccttc aacaattccc     6600

ttgatgtggc agctcatctt ccctacctct tccacgttgt tactttctta gtagccacag     6660

gtccgctctc ccttagagct tccacacatg gactggtcat taatatcatt cactctctgt     6720

gtacttgttc acagcttcat tttagtgaag agaccaagca agttttgaga ctcagtctga     6780

cagagttctc attacccaaa ttttacttgc tgtttggcat tagcaaagtc aagtcagctg     6840

ctgtcattgc cttccgttcc agttaccggg acaggtcatt ctctcctggc tcctatgaga     6900

gagagacttt tgctttgaca tccttggaaa cagtcacaga agctttgttg gagatcatgg     6960

aggcatgcat gagagatatt ccaacgtgca agtggctgga ccagtggaca gaactagctc     7020

aaagatttgc attccaatat aatccatccc tgcaaccaag agctcttgtt gtctttgggt     7080

gtattagcaa acgagtgtct catgggcaga taaagcagat aatccgtatt cttagcaagg     7140

cacttgagag ttgcttaaaa ggacctgaca cttacaacag tcaagttctg atagaagcta     7200

cagtaatagc actaaccaaa ttacagccac ttcttaataa ggactcgcct ctgcacaaag     7260

ccctcttttg ggtagctgtg gctgtgctgc agcttgatga ggtcaacttg tattcagcag     7320

gtaccgcact tcttgaacaa aacctgcata ctttagatag tctccgtata ttcaatgaca     7380

agagtccaga ggaagtattt atggcaatcc ggaatcctct ggagtggcac tgcaagcaaa     7440

tggatcattt tgttggactc aatttcaact ctaactttaa ctttgcattg gttggacacc     7500

ttttaaaagg gtacaggcat ccttcacctg ctattgttgc aagaacagtc agaattttac     7560

atacactact aactctggtt aacaaacaca gaaattgtga caaatttgaa gtgaatacac     7620

agagcgtggc ctacttagca gctttactta cagtgtctga agaagttcga agtcgctgca     7680

gcctaaaaca tagaaagtca cttcttctta ctgatatttc aatggaaaat gttcctatgg     7740

atacatatcc cattcatcat ggtgaccctt cctataggac actaaaggag actcagccat     7800

ggtcctctcc caaaggttct gaaggatacc ttgcagccac ctatccaact gtcggccaga     7860

ccagtccccg agccaggaaa tccatgagcc tggacatggg gcaaccttct caggccaaca     7920

ctaagaagtt gcttggaaca aggaaaagtt ttgatcactt gatatcagac acaaaggctc     7980

ctaaaaggca agaaatggaa tcagggatca caacaccccc caaaatgagg agagtagcag     8040

aaactgatta tgaaatggaa actcagagga tttcctcatc acaacagcac ccacatttac     8100

gtaaagtttc agtgtctgaa tcaaatgttc tcttggatga agaagtactt actgatccga     8160

agatccaggc gctgcttctt actgttctag ctacactggt aaaatatacc acagatgagt     8220

ttgatcaacg aattctttat gaatacttag cagaggccag tgttgtgttt cccaaagtct     8280

ttcctgttgt gcataatttg ttggactcta agatcaacac cctgttatca ttgtgccaag     8340

atccaaattt gttaaatcca atccatggaa ttgtgcagag tgtggtgtac catgaagaat     8400

ccccaccaca ataccaaaca tcttacctgc aaagttttgg ttttaatggc ttgtggcggt     8460

ttgcaggacc gttttcaaag caaacacaaa ttccagacta tgctgagctt attgttaagt     8520

ttcttgatgc cttgattgac acgtacctgc ctggaattga tgaagaaacc agtgaagaat     8580

ccctcctgac tcccacatct ccttaccctc ctgcactgca gagccagctt agtatcactg     8640

ccaaccttaa cctttctaat tccatgacct cacttgcaac ttcccagcat tccccaggaa     8700

tcgacaagga gaacgttgaa ctctccccta ccactggcca ctgtaacagt ggacgaactc     8760

gccacggatc cgcaagccaa gtgcagaagc aaagaagcgc tggcagtttc aaacgtaata     8820

gcattaagaa gatcgtgtga agcttgcttg ctttcttttt taaaatcaac ttaacatggg     8880

ctcttcacta gtgacccctt ccctgtcctt gccctttccc cccatgttgt aatgctgcac     8940

ttcctgtttt ataatgaacc catccggttt gccatgttgc cagatgatca actcttcgaa     9000

gccttgccta aatttaatgc tgccttttct ttaacttttt ttcttctact tttggcgtgt     9060

atctggtata tgtaagtgtt cagaacaact gcaaagaaag tgggaggtca ggaaactttt     9120

aactgagaaa tctcaattgt aagagaggat gaattcttga atactgctac tactggccag     9180

tgatgaaagc catttgcaca gagctctgcc ttctgtggtt ttcccttctt catcctacag     9240

agtaaagtgt tagtcctatt tatacatttt tcaagataca agtttatgag agaaatagta     9300

ttataacccc agtatgttta atcttttagc tgtggacttt ttttttaacc gtacaaaact     9360

gaaagaacca tagaggtcaa gcctcagtga cttgacacca taaagccaca gacaaggtac     9420

ttggggggga gggcagggaa atttcatatt ttatagtgga ttcttaagaa atactaacac     9480

ttgagtatta gcaataatta caggaaaata agtgcgacca catatatctt aacattactg     9540

aattaaaact atggcttcta agtccttatc caaactcagt catccaaact agtttatttt     9600

tttctccagt tgattatctt ttaattttta attttgctaa aggtggtttt tttgtgtttt     9660

gttttttgta aaccaaaact atactaagta tagtaattat atatatatat atattttttc     9720

ccctccccct cttctttcct aactaattct gagcagggta atcagtgaac aaagtgttga     9780

aaattgttcc cagaaggtaa ttttcataga tgtttgcatt agctccatag caaaatggaa     9840

tggtacgtga catttagggt agctgatatt tttattttgt taaataattt ccaagaatag     9900

agtatggtgt atattataaa tttctttgat aagatgtatt ttgaatgtct tttaatcttc     9960

ctcctcctct ccaaaaaaat cagaaacctc tttaagaaaa catgtaggtt atatatgcta    10020

gaattgcatt taatcactgt gaaaagactg gtcagcctgc attagtatga cagtaggggg    10080

gctgttagaa ttgctgctat actggtggta tggattatca tggcattgga attttcatag    10140

taatgcagat ccaatttctt tgtggtacct gcagtttaca aaataatttg acttcagtga    10200

gcatattggt atctggatgt tccaatttag aactaaacca tatttattac aaaaagatat    10260

taatccctct actcccaggt tccctttata tgttaagata taatggcttt gaggggggaa    10320

aaaataaacc taggggagag gggagtttcc tgtagtgctg tttcattaga ggatttcagt    10380

aaattaaatt ccacagctaa ttcaataaat aatggtacat ttaagtgttc tgattttaat    10440

aatatatttc acatttatcc acacagtaac aatgtaatat gttaatgtaa ataaaattgg    10500

ttttgatact cagaaataac aagaatttaa ttttttaaat ttgtttacag tcctgggaaa    10560

agtaagaatt atttgccaaa ataagaggaa agaaaacctt agtattatta atgagtttac    10620

catagaattg ttggaaatac tgaagacagg tgcaatttac taaacttttg tttttaaact    10680

attgtagagg ctgcattaga agaaaatgtt tataatgaca gagcaactat gactatataa    10740

aaaagctgaa attagaactg tgtttagaaa tagatcagta acccagtgcc aaggatgcca    10800

agctgccacc atggtcttgg ctctcccaca acccagtgtt tctggggtaa gtttcacagt    10860

ttctaggccc tggaatagca ggcagtgtaa gcctttgata actttagttc gatgtttttc    10920

ttgtttttgt ttgttggttt ggtgcatatg atagtgggtg ttatgctatt ttgctcttcc    10980

catcaaaata aagaaacttc cagaggttta ctgttaaaaa tactgatatt tccataaacg    11040

ggtttaccaa gggtgtagta tttcataccg cctgaaatga tcagcattgg cacaaatcaa    11100

aattcagccg cctttgaaat gcaaaaatac ctttgactag taagtacatc ctaggagttt    11160

gaaaacttaa ctaaggttta aaatttacct tgtttaaaga acttctgact tttgaggaaa    11220

atctagcttt ccaagtaact aaaatgtaca tgagataaac ctctcaccac tatgtgtccc    11280

ttgagaaatg caacactttt ttagtcttca tacttgtaat ctataaaaga aattctgaag    11340

tttagaccaa gttgcccatt tctgcgtaat tgacataagt tctgttaaaa atattataag    11400

taattcgttt cggtttgtag atgtttcccc tgacttgtta aagaggaaac caggaactca    11460

gtcatgtttt tgtcctggat aatctacctg ttatgccagt actcccatcc gaggggcatg    11520

cccttagttg cccagatgga gatgcagttc agtagatttg gggcaaagtg gctacagctc    11580

tgtcttccat tcactcaaca cctgttcatg actgagccag gtgcccagga cacatcctaa    11640

acagtcagct tctatcctgt gtcctagttg gggagacaga gtgccagcca gcaaccctcc    11700

caggtttgta ggttttaggg gttttcagtt ttgtttgggt tttttgtttt ttgtttttgt    11760

ttctacatcc ttccccgact cccaggcata atgaggcatg tcttactcaa tgttatgcaa    11820

tggatttagg caaaaattca ttcttagtgt cagccacaca atttttttta atgcagtata    11880

ttcacctgta aatagtttgt gtaaaatttg acaaaaaaag tatatttact atactgtaaa    11940

tatatgtgat gatatattgt attattttgc ttttttgtaa agcagttagt tgctgcacat    12000

ggataacaac aaaaatttga ttattctcgt gttagtattg ttaacttctt tttgcgactg    12060

cgttacatca tttaaagaaa atgctgtgta ttgtaaactt aaattgtata tgataactta    12120

ctgtcctttc catccgggcc taaactttgg cagttccttt gtctacaacc ttgttaatac    12180

tgtaaacagt tgtacgccag caggaaaaat actgcccaac agacaaaatc gatcattgta    12240

ggggaaaatc atagaaatcc atttcagatc tttattgttc ctcaccccat tttcctcctt    12300

gtgtatgtac ttcccccacc cccctttttt taagtaaaat gtaaattcaa tctgctctaa    12360

gaaaaaaaaa aaaaaaaaaa a                                              12381


<210>  2
<211>  2818
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln 
                565                 570                 575     


Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser 
            580                 585                 590         


Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn 
        595                 600                 605             


Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe 
    610                 615                 620                 


Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr 
625                 630                 635                 640 


Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala 
                645                 650                 655     


Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly 
            660                 665                 670         


Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu 
        675                 680                 685             


Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu 
    690                 695                 700                 


Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg 
705                 710                 715                 720 


Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn 
                725                 730                 735     


Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg 
            740                 745                 750         


Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His 
        755                 760                 765             


Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp 
    770                 775                 780                 


Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu 
785                 790                 795                 800 


Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg 
                805                 810                 815     


Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp 
            820                 825                 830         


Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly 
        835                 840                 845             


Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser 
    850                 855                 860                 


Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val 
865                 870                 875                 880 


Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp 
                885                 890                 895     


Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln 
            900                 905                 910         


Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala 
        915                 920                 925             


Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe 
    930                 935                 940                 


Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe 
945                 950                 955                 960 


Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr 
                965                 970                 975     


Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met 
            980                 985                 990         


Leu Asn Leu Val Arg Tyr Val Arg  Val Leu Gly Asn Met  Val His Ala 
        995                 1000                 1005             


Ile Gln  Ile Lys Thr Lys Leu  Cys Gln Leu Val Glu  Val Met Met 
    1010                 1015                 1020             


Ala Arg  Arg Asp Asp Leu Ser  Phe Cys Gln Glu Met  Lys Phe Arg 
    1025                 1030                 1035             


Asn Lys  Met Val Glu Tyr Leu  Thr Asp Trp Val Met  Gly Thr Ser 
    1040                 1045                 1050             


Asn Gln  Ala Ala Asp Asp Asp  Val Lys Cys Leu Thr  Arg Asp Leu 
    1055                 1060                 1065             


Asp Gln  Ala Ser Met Glu Ala  Val Val Ser Leu Leu  Ala Gly Leu 
    1070                 1075                 1080             


Pro Leu  Gln Pro Glu Glu Gly  Asp Gly Val Glu Leu  Met Glu Ala 
    1085                 1090                 1095             


Lys Ser  Gln Leu Phe Leu Lys  Tyr Phe Thr Leu Phe  Met Asn Leu 
    1100                 1105                 1110             


Leu Asn  Asp Cys Ser Glu Val  Glu Asp Glu Ser Ala  Gln Thr Gly 
    1115                 1120                 1125             


Gly Arg  Lys Arg Gly Met Ser  Arg Arg Leu Ala Ser  Leu Arg His 
    1130                 1135                 1140             


Cys Thr  Val Leu Ala Met Ser  Asn Leu Leu Asn Ala  Asn Val Asp 
    1145                 1150                 1155             


Ser Gly  Leu Met His Ser Ile  Gly Leu Gly Tyr His  Lys Asp Leu 
    1160                 1165                 1170             


Gln Thr  Arg Ala Thr Phe Met  Glu Val Leu Thr Lys  Ile Leu Gln 
    1175                 1180                 1185             


Gln Gly  Thr Glu Phe Asp Thr  Leu Ala Glu Thr Val  Leu Ala Asp 
    1190                 1195                 1200             


Arg Phe  Glu Arg Leu Val Glu  Leu Val Thr Met Met  Gly Asp Gln 
    1205                 1210                 1215             


Gly Glu  Leu Pro Ile Ala Met  Ala Leu Ala Asn Val  Val Pro Cys 
    1220                 1225                 1230             


Ser Gln  Trp Asp Glu Leu Ala  Arg Val Leu Val Thr  Leu Phe Asp 
    1235                 1240                 1245             


Ser Arg  His Leu Leu Tyr Gln  Leu Leu Trp Asn Met  Phe Ser Lys 
    1250                 1255                 1260             


Glu Val  Glu Leu Ala Asp Ser  Met Gln Thr Leu Phe  Arg Gly Asn 
    1265                 1270                 1275             


Ser Leu  Ala Ser Lys Ile Met  Thr Phe Cys Phe Lys  Val Tyr Gly 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Gln Lys Leu  Leu Asp Pro Leu Leu  Arg Ile Val 
    1295                 1300                 1305             


Ile Thr  Ser Ser Asp Trp Gln  His Val Ser Phe Glu  Val Asp Pro 
    1310                 1315                 1320             


Thr Arg  Leu Glu Pro Ser Glu  Ser Leu Glu Glu Asn  Gln Arg Asn 
    1325                 1330                 1335             


Leu Leu  Gln Met Thr Glu Lys  Phe Phe His Ala Ile  Ile Ser Ser 
    1340                 1345                 1350             


Ser Ser  Glu Phe Pro Pro Gln  Leu Arg Ser Val Cys  His Cys Leu 
    1355                 1360                 1365             


Tyr Gln  Val Val Ser Gln Arg  Phe Pro Gln Asn Ser  Ile Gly Ala 
    1370                 1375                 1380             


Val Gly  Ser Ala Met Phe Leu  Arg Phe Ile Asn Pro  Ala Ile Val 
    1385                 1390                 1395             


Ser Pro  Tyr Glu Ala Gly Ile  Leu Asp Lys Lys Pro  Pro Pro Arg 
    1400                 1405                 1410             


Ile Glu  Arg Gly Leu Lys Leu  Met Ser Lys Ile Leu  Gln Ser Ile 
    1415                 1420                 1425             


Ala Asn  His Val Leu Phe Thr  Lys Glu Glu His Met  Arg Pro Phe 
    1430                 1435                 1440             


Asn Asp  Phe Val Lys Ser Asn  Phe Asp Ala Ala Arg  Arg Phe Phe 
    1445                 1450                 1455             


Leu Asp  Ile Ala Ser Asp Cys  Pro Thr Ser Asp Ala  Val Asn His 
    1460                 1465                 1470             


Ser Leu  Ser Phe Ile Ser Asp  Gly Asn Val Leu Ala  Leu His Arg 
    1475                 1480                 1485             


Leu Leu  Trp Asn Asn Gln Glu  Lys Ile Gly Gln Tyr  Leu Ser Ser 
    1490                 1495                 1500             


Asn Arg  Asp His Lys Ala Val  Gly Arg Arg Pro Phe  Asp Lys Met 
    1505                 1510                 1515             


Ala Thr  Leu Leu Ala Tyr Leu  Gly Pro Pro Glu His  Lys Pro Val 
    1520                 1525                 1530             


Ala Asp  Thr His Trp Ser Ser  Leu Asn Leu Thr Ser  Ser Lys Phe 
    1535                 1540                 1545             


Glu Glu  Phe Met Thr Arg His  Gln Val His Glu Lys  Glu Glu Phe 
    1550                 1555                 1560             


Lys Ala  Leu Lys Thr Leu Ser  Ile Phe Tyr Gln Ala  Gly Thr Ser 
    1565                 1570                 1575             


Lys Ala  Gly Asn Pro Ile Phe  Tyr Tyr Val Ala Arg  Arg Phe Lys 
    1580                 1585                 1590             


Thr Gly  Gln Ile Asn Gly Asp  Leu Leu Ile Tyr His  Val Leu Leu 
    1595                 1600                 1605             


Thr Leu  Lys Pro Tyr Tyr Ala  Lys Pro Tyr Glu Ile  Val Val Asp 
    1610                 1615                 1620             


Leu Thr  His Thr Gly Pro Ser  Asn Arg Phe Lys Thr  Asp Phe Leu 
    1625                 1630                 1635             


Ser Lys  Trp Phe Val Val Phe  Pro Gly Phe Ala Tyr  Asp Asn Val 
    1640                 1645                 1650             


Ser Ala  Val Tyr Ile Tyr Asn  Cys Asn Ser Trp Val  Arg Glu Tyr 
    1655                 1660                 1665             


Thr Lys  Tyr His Glu Arg Leu  Leu Thr Gly Leu Lys  Gly Ser Lys 
    1670                 1675                 1680             


Arg Leu  Val Phe Ile Asp Cys  Pro Gly Lys Leu Ala  Glu His Ile 
    1685                 1690                 1695             


Glu His  Glu Gln Gln Lys Leu  Pro Ala Ala Thr Leu  Ala Leu Glu 
    1700                 1705                 1710             


Glu Asp  Leu Lys Val Phe His  Asn Ala Leu Lys Leu  Ala His Lys 
    1715                 1720                 1725             


Asp Thr  Lys Val Ser Ile Lys  Val Gly Ser Thr Ala  Val Gln Val 
    1730                 1735                 1740             


Thr Ser  Ala Glu Arg Thr Lys  Val Leu Gly Gln Ser  Val Phe Leu 
    1745                 1750                 1755             


Asn Asp  Ile Tyr Tyr Ala Ser  Glu Ile Glu Glu Ile  Cys Leu Val 
    1760                 1765                 1770             


Asp Glu  Asn Gln Phe Thr Leu  Thr Ile Ala Asn Gln  Gly Thr Pro 
    1775                 1780                 1785             


Leu Thr  Phe Met His Gln Glu  Cys Glu Ala Ile Val  Gln Ser Ile 
    1790                 1795                 1800             


Ile His  Ile Arg Thr Arg Trp  Glu Leu Ser Gln Pro  Asp Ser Ile 
    1805                 1810                 1815             


Pro Gln  His Thr Lys Ile Arg  Pro Lys Asp Val Pro  Gly Thr Leu 
    1820                 1825                 1830             


Leu Asn  Ile Ala Leu Leu Asn  Leu Gly Ser Ser Asp  Pro Ser Leu 
    1835                 1840                 1845             


Arg Ser  Ala Ala Tyr Asn Leu  Leu Cys Ala Leu Thr  Cys Thr Phe 
    1850                 1855                 1860             


Asn Leu  Lys Ile Glu Gly Gln  Leu Leu Glu Thr Ser  Gly Leu Cys 
    1865                 1870                 1875             


Ile Pro  Ala Asn Asn Thr Leu  Phe Ile Val Ser Ile  Ser Lys Thr 
    1880                 1885                 1890             


Leu Ala  Ala Asn Glu Pro His  Leu Thr Leu Glu Phe  Leu Glu Glu 
    1895                 1900                 1905             


Cys Ile  Ser Gly Phe Ser Lys  Ser Ser Ile Glu Leu  Lys His Leu 
    1910                 1915                 1920             


Cys Leu  Glu Tyr Met Thr Pro  Trp Leu Ser Asn Leu  Val Arg Phe 
    1925                 1930                 1935             


Cys Lys  His Asn Asp Asp Ala  Lys Arg Gln Arg Val  Thr Ala Ile 
    1940                 1945                 1950             


Leu Asp  Lys Leu Ile Thr Met  Thr Ile Asn Glu Lys  Gln Met Tyr 
    1955                 1960                 1965             


Pro Ser  Ile Gln Ala Lys Ile  Trp Gly Ser Leu Gly  Gln Ile Thr 
    1970                 1975                 1980             


Asp Leu  Leu Asp Val Val Leu  Asp Ser Phe Ile Lys  Thr Ser Ala 
    1985                 1990                 1995             


Thr Gly  Gly Leu Gly Ser Ile  Lys Ala Glu Val Met  Ala Asp Thr 
    2000                 2005                 2010             


Ala Val  Ala Leu Ala Ser Gly  Asn Val Lys Leu Val  Ser Ser Lys 
    2015                 2020                 2025             


Val Ile  Gly Arg Met Cys Lys  Ile Ile Asp Lys Thr  Cys Leu Ser 
    2030                 2035                 2040             


Pro Thr  Pro Thr Leu Glu Gln  His Leu Met Trp Asp  Asp Ile Ala 
    2045                 2050                 2055             


Ile Leu  Ala Arg Tyr Met Leu  Met Leu Ser Phe Asn  Asn Ser Leu 
    2060                 2065                 2070             


Asp Val  Ala Ala His Leu Pro  Tyr Leu Phe His Val  Val Thr Phe 
    2075                 2080                 2085             


Leu Val  Ala Thr Gly Pro Leu  Ser Leu Arg Ala Ser  Thr His Gly 
    2090                 2095                 2100             


Leu Val  Ile Asn Ile Ile His  Ser Leu Cys Thr Cys  Ser Gln Leu 
    2105                 2110                 2115             


His Phe  Ser Glu Glu Thr Lys  Gln Val Leu Arg Leu  Ser Leu Thr 
    2120                 2125                 2130             


Glu Phe  Ser Leu Pro Lys Phe  Tyr Leu Leu Phe Gly  Ile Ser Lys 
    2135                 2140                 2145             


Val Lys  Ser Ala Ala Val Ile  Ala Phe Arg Ser Ser  Tyr Arg Asp 
    2150                 2155                 2160             


Arg Ser  Phe Ser Pro Gly Ser  Tyr Glu Arg Glu Thr  Phe Ala Leu 
    2165                 2170                 2175             


Thr Ser  Leu Glu Thr Val Thr  Glu Ala Leu Leu Glu  Ile Met Glu 
    2180                 2185                 2190             


Ala Cys  Met Arg Asp Ile Pro  Thr Cys Lys Trp Leu  Asp Gln Trp 
    2195                 2200                 2205             


Thr Glu  Leu Ala Gln Arg Phe  Ala Phe Gln Tyr Asn  Pro Ser Leu 
    2210                 2215                 2220             


Gln Pro  Arg Ala Leu Val Val  Phe Gly Cys Ile Ser  Lys Arg Val 
    2225                 2230                 2235             


Ser His  Gly Gln Ile Lys Gln  Ile Ile Arg Ile Leu  Ser Lys Ala 
    2240                 2245                 2250             


Leu Glu  Ser Cys Leu Lys Gly  Pro Asp Thr Tyr Asn  Ser Gln Val 
    2255                 2260                 2265             


Leu Ile  Glu Ala Thr Val Ile  Ala Leu Thr Lys Leu  Gln Pro Leu 
    2270                 2275                 2280             


Leu Asn  Lys Asp Ser Pro Leu  His Lys Ala Leu Phe  Trp Val Ala 
    2285                 2290                 2295             


Val Ala  Val Leu Gln Leu Asp  Glu Val Asn Leu Tyr  Ser Ala Gly 
    2300                 2305                 2310             


Thr Ala  Leu Leu Glu Gln Asn  Leu His Thr Leu Asp  Ser Leu Arg 
    2315                 2320                 2325             


Ile Phe  Asn Asp Lys Ser Pro  Glu Glu Val Phe Met  Ala Ile Arg 
    2330                 2335                 2340             


Asn Pro  Leu Glu Trp His Cys  Lys Gln Met Asp His  Phe Val Gly 
    2345                 2350                 2355             


Leu Asn  Phe Asn Ser Asn Phe  Asn Phe Ala Leu Val  Gly His Leu 
    2360                 2365                 2370             


Leu Lys  Gly Tyr Arg His Pro  Ser Pro Ala Ile Val  Ala Arg Thr 
    2375                 2380                 2385             


Val Arg  Ile Leu His Thr Leu  Leu Thr Leu Val Asn  Lys His Arg 
    2390                 2395                 2400             


Asn Cys  Asp Lys Phe Glu Val  Asn Thr Gln Ser Val  Ala Tyr Leu 
    2405                 2410                 2415             


Ala Ala  Leu Leu Thr Val Ser  Glu Glu Val Arg Ser  Arg Cys Ser 
    2420                 2425                 2430             


Leu Lys  His Arg Lys Ser Leu  Leu Leu Thr Asp Ile  Ser Met Glu 
    2435                 2440                 2445             


Asn Val  Pro Met Asp Thr Tyr  Pro Ile His His Gly  Asp Pro Ser 
    2450                 2455                 2460             


Tyr Arg  Thr Leu Lys Glu Thr  Gln Pro Trp Ser Ser  Pro Lys Gly 
    2465                 2470                 2475             


Ser Glu  Gly Tyr Leu Ala Ala  Thr Tyr Pro Thr Val  Gly Gln Thr 
    2480                 2485                 2490             


Ser Pro  Arg Ala Arg Lys Ser  Met Ser Leu Asp Met  Gly Gln Pro 
    2495                 2500                 2505             


Ser Gln  Ala Asn Thr Lys Lys  Leu Leu Gly Thr Arg  Lys Ser Phe 
    2510                 2515                 2520             


Asp His  Leu Ile Ser Asp Thr  Lys Ala Pro Lys Arg  Gln Glu Met 
    2525                 2530                 2535             


Glu Ser  Gly Ile Thr Thr Pro  Pro Lys Met Arg Arg  Val Ala Glu 
    2540                 2545                 2550             


Thr Asp  Tyr Glu Met Glu Thr  Gln Arg Ile Ser Ser  Ser Gln Gln 
    2555                 2560                 2565             


His Pro  His Leu Arg Lys Val  Ser Val Ser Glu Ser  Asn Val Leu 
    2570                 2575                 2580             


Leu Asp  Glu Glu Val Leu Thr  Asp Pro Lys Ile Gln  Ala Leu Leu 
    2585                 2590                 2595             


Leu Thr  Val Leu Ala Thr Leu  Val Lys Tyr Thr Thr  Asp Glu Phe 
    2600                 2605                 2610             


Asp Gln  Arg Ile Leu Tyr Glu  Tyr Leu Ala Glu Ala  Ser Val Val 
    2615                 2620                 2625             


Phe Pro  Lys Val Phe Pro Val  Val His Asn Leu Leu  Asp Ser Lys 
    2630                 2635                 2640             


Ile Asn  Thr Leu Leu Ser Leu  Cys Gln Asp Pro Asn  Leu Leu Asn 
    2645                 2650                 2655             


Pro Ile  His Gly Ile Val Gln  Ser Val Val Tyr His  Glu Glu Ser 
    2660                 2665                 2670             


Pro Pro  Gln Tyr Gln Thr Ser  Tyr Leu Gln Ser Phe  Gly Phe Asn 
    2675                 2680                 2685             


Gly Leu  Trp Arg Phe Ala Gly  Pro Phe Ser Lys Gln  Thr Gln Ile 
    2690                 2695                 2700             


Pro Asp  Tyr Ala Glu Leu Ile  Val Lys Phe Leu Asp  Ala Leu Ile 
    2705                 2710                 2715             


Asp Thr  Tyr Leu Pro Gly Ile  Asp Glu Glu Thr Ser  Glu Glu Ser 
    2720                 2725                 2730             


Leu Leu  Thr Pro Thr Ser Pro  Tyr Pro Pro Ala Leu  Gln Ser Gln 
    2735                 2740                 2745             


Leu Ser  Ile Thr Ala Asn Leu  Asn Leu Ser Asn Ser  Met Thr Ser 
    2750                 2755                 2760             


Leu Ala  Thr Ser Gln His Ser  Pro Gly Ile Asp Lys  Glu Asn Val 
    2765                 2770                 2775             


Glu Leu  Ser Pro Thr Thr Gly  His Cys Asn Ser Gly  Arg Thr Arg 
    2780                 2785                 2790             


His Gly  Ser Ala Ser Gln Val  Gln Lys Gln Arg Ser  Ala Gly Ser 
    2795                 2800                 2805             


Phe Lys  Arg Asn Ser Ile Lys  Lys Ile Val 
    2810                 2815             


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
1               5                   10  


<210>  4
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  4
tacccatacg atgttccaga ttacgct                                           27


<210>  5
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  5
tatccatatg atgttccaga ttatgct                                           27


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  7
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Tyr Pro Tyr Asp Val Pro Asp 
1               5                   10                  15      


Tyr Ala 
        


<210>  8
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Tyr Pro Tyr Asp Val Pro Asp 
1               5                   10                  15      


Tyr Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            20                  25          


<210>  9
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Tyr Pro Tyr Asp Val Pro Asp 
1               5                   10                  15      


Tyr Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Tyr Pro Tyr Asp Val 
            20                  25                  30          


Pro Asp Tyr Ala 
        35      


<210>  10
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  10

His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly Cys 
1               5                   10                  15      


Met Ser Cys Lys Cys Val Leu Ser 
            20                  


<210>  11
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  11

Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp Gly Thr Gln Gly Cys 
1               5                   10                  15      


Met Gly Leu Pro Cys Val Val Met 
            20                  


<210>  12
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  12

Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys Val 
1               5                   10                  15      


Lys Ile Lys Lys Cys Ile Ile Met 
            20                  


<210>  13
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ser Lys Thr Lys Cys Val Ile Met 
            20                  


<210>  14
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
1               5                   10  


<210>  15
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys Ser Lys Thr 
1               5                   10                  15      


Lys Cys Val Ile Met 
            20      


<210>  16
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  16

Leu Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys Val Lys Ile 
1               5                   10                  15      


Lys Lys Cys Ile Ile Met 
            20          


<210>  17
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  17

His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly Cys 
1               5                   10                  15      


Met Ser Cys Lys Cys Val Leu Ser 
            20                  


<210>  18
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  18

Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp Gly Thr Gln Gly Cys 
1               5                   10                  15      


Met Gly Leu Pro Cys Val Val Met 
            20                  


<210>  19
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  19

Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys Val 
1               5                   10                  15      


Lys Ile Lys Lys Cys Ile Ile Met 
            20                  


<210>  20
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ser Lys Thr Lys Cys Val Ile Met 
            20                  


<210>  21
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly 
1               5                   10                  15      


Cys Met Ser Cys Lys Cys Val Leu Ser 
            20                  25  


<210>  22
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp Gly Thr Gln Gly 
1               5                   10                  15      


Cys Met Gly Leu Pro Cys Val Val Met 
            20                  25  


<210>  23
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys 
1               5                   10                  15      


Val Lys Ile Lys Lys Cys Ile Ile Met 
            20                  25  


<210>  24
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  24

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ser Lys Thr Lys Cys Val Ile Met 
            20                  


<210>  25
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  25

Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly 
1               5                   10                  15      


Cys Met Ser Cys Lys Cys Val Ser 
            20                  


<210>  26
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly 
1               5                   10                  15      


Cys Met Ser Cys Lys Cys Val Leu Ser 
            20                  25  


<210>  27
<211>  25
<212>  PRT
<213>  Chlorocebus sabaeus

<400>  27

Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly 
1               5                   10                  15      


Cys Met Ser Cys Lys Cys Val Leu Ser 
            20                  25  


<210>  28
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  28

Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly 
1               5                   10                  15      


Cys Met Ser Cys Lys Cys Val Leu Ser 
            20                  25  


<210>  29
<211>  25
<212>  PRT
<213>  Rattus norvegicus

<400>  29

Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly 
1               5                   10                  15      


Cys Met Ser Cys Lys Cys Val Leu Ser 
            20                  25  


<210>  30
<211>  24
<212>  PRT
<213>  Gallus gallus

<400>  30

Gln His Lys Leu Arg Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly Cys 
1               5                   10                  15      


Met Asn Cys Lys Cys Val Ile Ser 
            20                  


<210>  31
<211>  24
<212>  PRT
<213>  Alligator mississippiensis

<400>  31

Gln His Lys Leu Arg Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly Cys 
1               5                   10                  15      


Met Asn Cys Lys Cys Val Ile Ser 
            20                  


<210>  32
<211>  24
<212>  PRT
<213>  Chelonia mydas

<400>  32

Gln His Lys Leu Arg Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly Cys 
1               5                   10                  15      


Met Asn Cys Lys Cys Val Ile Ser 
            20                  


<210>  33
<211>  25
<212>  PRT
<213>  Xenopus tropicalis

<400>  33

Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu Ser Glu Lys Gly 
1               5                   10                  15      


Cys Leu Asn Cys Lys Cys Val Val Ser 
            20                  25  


<210>  34
<211>  25
<212>  PRT
<213>  Danio rerio

<400>  34

Gln His Lys Met Arg Lys Leu Asn Pro Pro Asp Glu Ser Gly Gln Asp 
1               5                   10                  15      


Cys Met Ser Cys Arg Cys Val Val Ser 
            20                  25  


<210>  35
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  35

Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Glu Asp Gly Gln Gly Cys 
1               5                   10                  15      


Met Gly Leu Pro Cys Val Met 
            20              


<210>  36
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp Gly Thr Gln Gly 
1               5                   10                  15      


Cys Met Gly Leu Pro Cys Val Val Met 
            20                  25  


<210>  37
<211>  25
<212>  PRT
<213>  Chlorocebus sabaeus

<400>  37

Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp Gly Thr Gln Gly 
1               5                   10                  15      


Cys Met Gly Leu Pro Cys Val Val Met 
            20                  25  


<210>  38
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  38

Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp Gly Thr Gln Gly 
1               5                   10                  15      


Cys Met Gly Leu Pro Cys Val Leu Met 
            20                  25  


<210>  39
<211>  25
<212>  PRT
<213>  Rattus norvegicus

<400>  39

Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Glu Asp Gly Thr Gln Gly 
1               5                   10                  15      


Cys Met Gly Leu Pro Cys Val Val Met 
            20                  25  


<210>  40
<211>  25
<212>  PRT
<213>  Gallus gallus

<400>  40

Gln Tyr Arg Met Lys Lys Leu Asn Ser Asn Glu Asp Gly Asn Gln Gly 
1               5                   10                  15      


Cys Met Gly Leu Ser Cys Ile Val Met 
            20                  25  


<210>  41
<211>  25
<212>  PRT
<213>  Alligator mississippiensis

<400>  41

Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Glu Asp Gly Asn Gln Gly 
1               5                   10                  15      


Cys Met Gly Val Ser Cys Ile Met Met 
            20                  25  


<210>  42
<211>  25
<212>  PRT
<213>  Chelonia mydas

<400>  42

Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Glu Asp Gly Asn Gln Gly 
1               5                   10                  15      


Cys Met Gly Leu Ser Cys Ile Val Met 
            20                  25  


<210>  43
<211>  25
<212>  PRT
<213>  Xenopus tropicalis

<400>  43

Gln Tyr Arg Met Lys Lys Leu Asp Ser Ser Glu Asp Asn Asn Gln Gly 
1               5                   10                  15      


Cys Ile Arg Ile Pro Cys Lys Leu Met 
            20                  25  


<210>  44
<211>  24
<212>  PRT
<213>  Danio rerio

<400>  44

Tyr Arg Met Lys Lys Leu Asn Ser Arg Glu Asp Arg Lys Gln Gly Cys 
1               5                   10                  15      


Leu Gly Val Ser Cys Glu Val Met 
            20                  


<210>  45
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  45

Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys 
1               5                   10                  15      


Val Lys Ile Lys Lys Cys Met 
            20              


<210>  46
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  46

Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys 
1               5                   10                  15      


Val Lys Ile Lys Lys Cys Ile Ile Met 
            20                  25  


<210>  47
<211>  25
<212>  PRT
<213>  Chlorocebus sabaeus

<400>  47

Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys 
1               5                   10                  15      


Val Lys Ile Lys Lys Cys Ile Ile Met 
            20                  25  


<210>  48
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  48

Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys 
1               5                   10                  15      


Val Lys Ile Lys Lys Cys Val Ile Met 
            20                  25  


<210>  49
<211>  25
<212>  PRT
<213>  Rattus norvegicus

<400>  49

Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys 
1               5                   10                  15      


Val Lys Ile Lys Lys Cys Val Ile Met 
            20                  25  


<210>  50
<211>  25
<212>  PRT
<213>  Gallus gallus

<400>  50

Gln Tyr Arg Val Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys 
1               5                   10                  15      


Met Lys Ile Lys Lys Cys Leu Val Met 
            20                  25  


<210>  51
<211>  25
<212>  PRT
<213>  Alligator mississippiensis

<400>  51

Gln Tyr Arg Val Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys 
1               5                   10                  15      


Val Lys Ile Lys Lys Cys Leu Val Met 
            20                  25  


<210>  52
<211>  25
<212>  PRT
<213>  Chelonia mydas

<400>  52

Gln Tyr Arg Val Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys 
1               5                   10                  15      


Val Lys Ile Lys Lys Cys Leu Val Met 
            20                  25  


<210>  53
<211>  25
<212>  PRT
<213>  Xenopus tropicalis

<400>  53

Gln Phe Arg Leu Thr Lys Met Ser Lys Glu Glu Lys Thr Pro Gly Cys 
1               5                   10                  15      


Val Lys Phe Lys Lys Cys Arg Val Met 
            20                  25  


<210>  54
<211>  25
<212>  PRT
<213>  Danio rerio

<400>  54

Glu Tyr Arg Leu Arg Lys Leu Ser Lys Glu Glu Lys Thr Thr Gln Cys 
1               5                   10                  15      


Ile Lys Leu Lys Lys Cys Val Leu Met 
            20                  25  


<210>  55
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  55

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ser Lys Thr Lys Cys Ile Met 
            20              


<210>  56
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  56

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ser Lys Thr Lys Cys Val Ile Met 
            20                  


<210>  57
<211>  24
<212>  PRT
<213>  Chlorocebus sabaeus

<400>  57

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ser Lys Thr Lys Cys Val Ile Met 
            20                  


<210>  58
<211>  24
<212>  PRT
<213>  Mus musculus

<400>  58

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ser Arg Thr Arg Cys Thr Val Met 
            20                  


<210>  59
<211>  24
<212>  PRT
<213>  Rattus norvegicus

<400>  59

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ser Arg Thr Arg Cys Thr Val Met 
            20                  


<210>  60
<211>  24
<212>  PRT
<213>  Gallus gallus

<400>  60

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Thr Lys Thr Lys Cys Ile Ile Met 
            20                  


<210>  61
<211>  24
<212>  PRT
<213>  Alligator mississippiensis

<400>  61

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Thr Lys Thr Lys Cys Ile Ile Met 
            20                  


<210>  62
<211>  24
<212>  PRT
<213>  Chelonia mydas

<400>  62

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Thr Lys Thr Lys Cys Ile Ile Met 
            20                  


<210>  63
<211>  24
<212>  PRT
<213>  Xenopus tropicalis

<400>  63

Lys His Lys Glu Lys Met Ser Lys Glu Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ser Lys Thr Lys Cys Ala Leu Met 
            20                  


<210>  64
<211>  23
<212>  PRT
<213>  Danio rerio

<400>  64

Lys His Lys Glu Lys Met Ser Lys Gly Asp Lys Lys Lys Lys Lys Ser 
1               5                   10                  15      


Lys Thr Lys Cys Ser Ile Leu 
            20              


