                         SEQUENCE LISTING

<110>  Broad Institute, Inc.
       Dana Farber Cancer Institute, Inc.
 
<120>  TEPOXALIN TARGETING OF ABCB1 OVEREXPRESSING CANCERS

<130>  52199-537001WO

<150>  62/758,294
<151>  2018-11-09

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  4363
<212>  DNA
<213>  Homo sapiens

<400>  1
gctcattcga gtagcggctc ttccaagctc aaagaagcag aggccgctgt tcgtttcctt       60

taggtctttc cactaaagtc ggagtatctt cttccaaaat ttcacgtctt ggtggccgtt      120

ccaaggagcg cgaggtcgga atggatcttg aaggggaccg caatggagga gcaaagaaga      180

agaacttttt taaactgaac aataaaagtg aaaaagataa gaaggaaaag aaaccaactg      240

tcagtgtatt ttcaatgttt cgctattcaa attggcttga caagttgtat atggtggtgg      300

gaactttggc tgccatcatc catggggctg gacttcctct catgatgctg gtgtttggag      360

aaatgacaga tatctttgca aatgcaggaa atttagaaga tctgatgtca aacatcacta      420

atagaagtga tatcaatgat acagggttct tcatgaatct ggaggaagac atgaccaggt      480

atgcctatta ttacagtgga attggtgctg gggtgctggt tgctgcttac attcaggttt      540

cattttggtg cctggcagct ggaagacaaa tacacaaaat tagaaaacag ttttttcatg      600

ctataatgcg acaggagata ggctggtttg atgtgcacga tgttggggag cttaacaccc      660

gacttacaga tgatgtctcc aagattaatg aaggaattgg tgacaaaatt ggaatgttct      720

ttcagtcaat ggcaacattt ttcactgggt ttatagtagg atttacacgt ggttggaagc      780

taacccttgt gattttggcc atcagtcctg ttcttggact gtcagctgct gtctgggcaa      840

agatactatc ttcatttact gataaagaac tcttagcgta tgcaaaagct ggagcagtag      900

ctgaagaggt cttggcagca attagaactg tgattgcatt tggaggacaa aagaaagaac      960

ttgaaaggta caacaaaaat ttagaagaag ctaaaagaat tgggataaag aaagctatta     1020

cagccaatat ttctataggt gctgctttcc tgctgatcta tgcatcttat gctctggcct     1080

tctggtatgg gaccaccttg gtcctctcag gggaatattc tattggacaa gtactcactg     1140

tattcttttc tgtattaatt ggggctttta gtgttggaca ggcatctcca agcattgaag     1200

catttgcaaa tgcaagagga gcagcttatg aaatcttcaa gataattgat aataagccaa     1260

gtattgacag ctattcgaag agtgggcaca aaccagataa tattaaggga aatttggaat     1320

tcagaaatgt tcacttcagt tacccatctc gaaaagaagt taagatcttg aagggtctga     1380

acctgaaggt gcagagtggg cagacggtgg ccctggttgg aaacagtggc tgtgggaaga     1440

gcacaacagt ccagctgatg cagaggctct atgaccccac agaggggatg gtcagtgttg     1500

atggacagga tattaggacc ataaatgtaa ggtttctacg ggaaatcatt ggtgtggtga     1560

gtcaggaacc tgtattgttt gccaccacga tagctgaaaa cattcgctat ggccgtgaaa     1620

atgtcaccat ggatgagatt gagaaagctg tcaaggaagc caatgcctat gactttatca     1680

tgaaactgcc tcataaattt gacaccctgg ttggagagag aggggcccag ttgagtggtg     1740

ggcagaagca gaggatcgcc attgcacgtg ccctggttcg caaccccaag atcctcctgc     1800

tggatgaggc cacgtcagcc ttggacacag aaagcgaagc agtggttcag gtggctctgg     1860

ataaggccag aaaaggtcgg accaccattg tgatagctca tcgtttgtct acagttcgta     1920

atgctgacgt catcgctggt ttcgatgatg gagtcattgt ggagaaagga aatcatgatg     1980

aactcatgaa agagaaaggc atttacttca aacttgtcac aatgcagaca gcaggaaatg     2040

aagttgaatt agaaaatgca gctgatgaat ccaaaagtga aattgatgcc ttggaaatgt     2100

cttcaaatga ttcaagatcc agtctaataa gaaaaagatc aactcgtagg agtgtccgtg     2160

gatcacaagc ccaagacaga aagcttagta ccaaagaggc tctggatgaa agtatacctc     2220

cagtttcctt ttggaggatt atgaagctaa atttaactga atggccttat tttgttgttg     2280

gtgtattttg tgccattata aatggaggcc tgcaaccagc atttgcaata atattttcaa     2340

agattatagg ggtttttaca agaattgatg atcctgaaac aaaacgacag aatagtaact     2400

tgttttcact attgtttcta gcccttggaa ttatttcttt tattacattt ttccttcagg     2460

gtttcacatt tggcaaagct ggagagatcc tcaccaagcg gctccgatac atggttttcc     2520

gatccatgct cagacaggat gtgagttggt ttgatgaccc taaaaacacc actggagcat     2580

tgactaccag gctcgccaat gatgctgctc aagttaaagg ggctataggt tccaggcttg     2640

ctgtaattac ccagaatata gcaaatcttg ggacaggaat aattatatcc ttcatctatg     2700

gttggcaact aacactgtta ctcttagcaa ttgtacccat cattgcaata gcaggagttg     2760

ttgaaatgaa aatgttgtct ggacaagcac tgaaagataa gaaagaacta gaaggttctg     2820

ggaagatcgc tactgaagca atagaaaact tccgaaccgt tgtttctttg actcaggagc     2880

agaagtttga acatatgtat gctcagagtt tgcaggtacc atacagaaac tctttgagga     2940

aagcacacat ctttggaatt acattttcct tcacccaggc aatgatgtat ttttcctatg     3000

ctggatgttt ccggtttgga gcctacttgg tggcacataa actcatgagc tttgaggatg     3060

ttctgttagt attttcagct gttgtctttg gtgccatggc cgtggggcaa gtcagttcat     3120

ttgctcctga ctatgccaaa gccaaaatat cagcagccca catcatcatg atcattgaaa     3180

aaaccccttt gattgacagc tacagcacgg aaggcctaat gccgaacaca ttggaaggaa     3240

atgtcacatt tggtgaagtt gtattcaact atcccacccg accggacatc ccagtgcttc     3300

agggactgag cctggaggtg aagaagggcc agacgctggc tctggtgggc agcagtggct     3360

gtgggaagag cacagtggtc cagctcctgg agcggttcta cgaccccttg gcagggaaag     3420

tgctgcttga tggcaaagaa ataaagcgac tgaatgttca gtggctccga gcacacctgg     3480

gcatcgtgtc ccaggagccc atcctgtttg actgcagcat tgctgagaac attgcctatg     3540

gagacaacag ccgggtggtg tcacaggaag agattgtgag ggcagcaaag gaggccaaca     3600

tacatgcctt catcgagtca ctgcctaata aatatagcac taaagtagga gacaaaggaa     3660

ctcagctctc tggtggccag aaacaacgca ttgccatagc tcgtgccctt gttagacagc     3720

ctcatatttt gcttttggat gaagccacgt cagctctgga tacagaaagt gaaaaggttg     3780

tccaagaagc cctggacaaa gccagagaag gccgcacctg cattgtgatt gctcaccgcc     3840

tgtccaccat ccagaatgca gacttaatag tggtgtttca gaatggcaga gtcaaggagc     3900

atggcacgca tcagcagctg ctggcacaga aaggcatcta tttttcaatg gtcagtgtcc     3960

aggctggaac aaagcgccag tgaactctga ctgtatgaga tgttaaatac tttttaatat     4020

ttgtttagat atgacattta ttcaaagtta aaagcaaaca cttacagaat tatgaagagg     4080

tatctgttta acatttcctc agtcaagttc agagtcttca gagacttcgt aattaaagga     4140

acagagtgag agacatcatc aagtggagag aaatcatagt ttaaactgca ttataaattt     4200

tataacagaa ttaaagtaga ttttaaaaga taaaatgtgt aattttgttt atattttccc     4260

atttggactg taactgactg ccttgctaaa agattataga agtagcaaaa agtattgaaa     4320

tgtttgcata aagtgtctat aataaaacta aactttcatg tga                       4363


<210>  2
<211>  1280
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Leu Glu Gly Asp Arg Asn Gly Gly Ala Lys Lys Lys Asn Phe 
1               5                   10                  15      


Phe Lys Leu Asn Asn Lys Ser Glu Lys Asp Lys Lys Glu Lys Lys Pro 
            20                  25                  30          


Thr Val Ser Val Phe Ser Met Phe Arg Tyr Ser Asn Trp Leu Asp Lys 
        35                  40                  45              


Leu Tyr Met Val Val Gly Thr Leu Ala Ala Ile Ile His Gly Ala Gly 
    50                  55                  60                  


Leu Pro Leu Met Met Leu Val Phe Gly Glu Met Thr Asp Ile Phe Ala 
65                  70                  75                  80  


Asn Ala Gly Asn Leu Glu Asp Leu Met Ser Asn Ile Thr Asn Arg Ser 
                85                  90                  95      


Asp Ile Asn Asp Thr Gly Phe Phe Met Asn Leu Glu Glu Asp Met Thr 
            100                 105                 110         


Arg Tyr Ala Tyr Tyr Tyr Ser Gly Ile Gly Ala Gly Val Leu Val Ala 
        115                 120                 125             


Ala Tyr Ile Gln Val Ser Phe Trp Cys Leu Ala Ala Gly Arg Gln Ile 
    130                 135                 140                 


His Lys Ile Arg Lys Gln Phe Phe His Ala Ile Met Arg Gln Glu Ile 
145                 150                 155                 160 


Gly Trp Phe Asp Val His Asp Val Gly Glu Leu Asn Thr Arg Leu Thr 
                165                 170                 175     


Asp Asp Val Ser Lys Ile Asn Glu Gly Ile Gly Asp Lys Ile Gly Met 
            180                 185                 190         


Phe Phe Gln Ser Met Ala Thr Phe Phe Thr Gly Phe Ile Val Gly Phe 
        195                 200                 205             


Thr Arg Gly Trp Lys Leu Thr Leu Val Ile Leu Ala Ile Ser Pro Val 
    210                 215                 220                 


Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ser Phe Thr 
225                 230                 235                 240 


Asp Lys Glu Leu Leu Ala Tyr Ala Lys Ala Gly Ala Val Ala Glu Glu 
                245                 250                 255     


Val Leu Ala Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln Lys Lys 
            260                 265                 270         


Glu Leu Glu Arg Tyr Asn Lys Asn Leu Glu Glu Ala Lys Arg Ile Gly 
        275                 280                 285             


Ile Lys Lys Ala Ile Thr Ala Asn Ile Ser Ile Gly Ala Ala Phe Leu 
    290                 295                 300                 


Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Thr Thr Leu 
305                 310                 315                 320 


Val Leu Ser Gly Glu Tyr Ser Ile Gly Gln Val Leu Thr Val Phe Phe 
                325                 330                 335     


Ser Val Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ser Pro Ser Ile 
            340                 345                 350         


Glu Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Glu Ile Phe Lys Ile 
        355                 360                 365             


Ile Asp Asn Lys Pro Ser Ile Asp Ser Tyr Ser Lys Ser Gly His Lys 
    370                 375                 380                 


Pro Asp Asn Ile Lys Gly Asn Leu Glu Phe Arg Asn Val His Phe Ser 
385                 390                 395                 400 


Tyr Pro Ser Arg Lys Glu Val Lys Ile Leu Lys Gly Leu Asn Leu Lys 
                405                 410                 415     


Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Asn Ser Gly Cys Gly 
            420                 425                 430         


Lys Ser Thr Thr Val Gln Leu Met Gln Arg Leu Tyr Asp Pro Thr Glu 
        435                 440                 445             


Gly Met Val Ser Val Asp Gly Gln Asp Ile Arg Thr Ile Asn Val Arg 
    450                 455                 460                 


Phe Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe 
465                 470                 475                 480 


Ala Thr Thr Ile Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asn Val Thr 
                485                 490                 495     


Met Asp Glu Ile Glu Lys Ala Val Lys Glu Ala Asn Ala Tyr Asp Phe 
            500                 505                 510         


Ile Met Lys Leu Pro His Lys Phe Asp Thr Leu Val Gly Glu Arg Gly 
        515                 520                 525             


Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala 
    530                 535                 540                 


Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala 
545                 550                 555                 560 


Leu Asp Thr Glu Ser Glu Ala Val Val Gln Val Ala Leu Asp Lys Ala 
                565                 570                 575     


Arg Lys Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser Thr Val 
            580                 585                 590         


Arg Asn Ala Asp Val Ile Ala Gly Phe Asp Asp Gly Val Ile Val Glu 
        595                 600                 605             


Lys Gly Asn His Asp Glu Leu Met Lys Glu Lys Gly Ile Tyr Phe Lys 
    610                 615                 620                 


Leu Val Thr Met Gln Thr Ala Gly Asn Glu Val Glu Leu Glu Asn Ala 
625                 630                 635                 640 


Ala Asp Glu Ser Lys Ser Glu Ile Asp Ala Leu Glu Met Ser Ser Asn 
                645                 650                 655     


Asp Ser Arg Ser Ser Leu Ile Arg Lys Arg Ser Thr Arg Arg Ser Val 
            660                 665                 670         


Arg Gly Ser Gln Ala Gln Asp Arg Lys Leu Ser Thr Lys Glu Ala Leu 
        675                 680                 685             


Asp Glu Ser Ile Pro Pro Val Ser Phe Trp Arg Ile Met Lys Leu Asn 
    690                 695                 700                 


Leu Thr Glu Trp Pro Tyr Phe Val Val Gly Val Phe Cys Ala Ile Ile 
705                 710                 715                 720 


Asn Gly Gly Leu Gln Pro Ala Phe Ala Ile Ile Phe Ser Lys Ile Ile 
                725                 730                 735     


Gly Val Phe Thr Arg Ile Asp Asp Pro Glu Thr Lys Arg Gln Asn Ser 
            740                 745                 750         


Asn Leu Phe Ser Leu Leu Phe Leu Ala Leu Gly Ile Ile Ser Phe Ile 
        755                 760                 765             


Thr Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu 
    770                 775                 780                 


Thr Lys Arg Leu Arg Tyr Met Val Phe Arg Ser Met Leu Arg Gln Asp 
785                 790                 795                 800 


Val Ser Trp Phe Asp Asp Pro Lys Asn Thr Thr Gly Ala Leu Thr Thr 
                805                 810                 815     


Arg Leu Ala Asn Asp Ala Ala Gln Val Lys Gly Ala Ile Gly Ser Arg 
            820                 825                 830         


Leu Ala Val Ile Thr Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile 
        835                 840                 845             


Ile Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Ile 
    850                 855                 860                 


Val Pro Ile Ile Ala Ile Ala Gly Val Val Glu Met Lys Met Leu Ser 
865                 870                 875                 880 


Gly Gln Ala Leu Lys Asp Lys Lys Glu Leu Glu Gly Ser Gly Lys Ile 
                885                 890                 895     


Ala Thr Glu Ala Ile Glu Asn Phe Arg Thr Val Val Ser Leu Thr Gln 
            900                 905                 910         


Glu Gln Lys Phe Glu His Met Tyr Ala Gln Ser Leu Gln Val Pro Tyr 
        915                 920                 925             


Arg Asn Ser Leu Arg Lys Ala His Ile Phe Gly Ile Thr Phe Ser Phe 
    930                 935                 940                 


Thr Gln Ala Met Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly 
945                 950                 955                 960 


Ala Tyr Leu Val Ala His Lys Leu Met Ser Phe Glu Asp Val Leu Leu 
                965                 970                 975     


Val Phe Ser Ala Val Val Phe Gly Ala Met Ala Val Gly Gln Val Ser 
            980                 985                 990         


Ser Phe Ala Pro Asp Tyr Ala Lys  Ala Lys Ile Ser Ala  Ala His Ile 
        995                 1000                 1005             


Ile Met  Ile Ile Glu Lys Thr  Pro Leu Ile Asp Ser  Tyr Ser Thr 
    1010                 1015                 1020             


Glu Gly  Leu Met Pro Asn Thr  Leu Glu Gly Asn Val  Thr Phe Gly 
    1025                 1030                 1035             


Glu Val  Val Phe Asn Tyr Pro  Thr Arg Pro Asp Ile  Pro Val Leu 
    1040                 1045                 1050             


Gln Gly  Leu Ser Leu Glu Val  Lys Lys Gly Gln Thr  Leu Ala Leu 
    1055                 1060                 1065             


Val Gly  Ser Ser Gly Cys Gly  Lys Ser Thr Val Val  Gln Leu Leu 
    1070                 1075                 1080             


Glu Arg  Phe Tyr Asp Pro Leu  Ala Gly Lys Val Leu  Leu Asp Gly 
    1085                 1090                 1095             


Lys Glu  Ile Lys Arg Leu Asn  Val Gln Trp Leu Arg  Ala His Leu 
    1100                 1105                 1110             


Gly Ile  Val Ser Gln Glu Pro  Ile Leu Phe Asp Cys  Ser Ile Ala 
    1115                 1120                 1125             


Glu Asn  Ile Ala Tyr Gly Asp  Asn Ser Arg Val Val  Ser Gln Glu 
    1130                 1135                 1140             


Glu Ile  Val Arg Ala Ala Lys  Glu Ala Asn Ile His  Ala Phe Ile 
    1145                 1150                 1155             


Glu Ser  Leu Pro Asn Lys Tyr  Ser Thr Lys Val Gly  Asp Lys Gly 
    1160                 1165                 1170             


Thr Gln  Leu Ser Gly Gly Gln  Lys Gln Arg Ile Ala  Ile Ala Arg 
    1175                 1180                 1185             


Ala Leu  Val Arg Gln Pro His  Ile Leu Leu Leu Asp  Glu Ala Thr 
    1190                 1195                 1200             


Ser Ala  Leu Asp Thr Glu Ser  Glu Lys Val Val Gln  Glu Ala Leu 
    1205                 1210                 1215             


Asp Lys  Ala Arg Glu Gly Arg  Thr Cys Ile Val Ile  Ala His Arg 
    1220                 1225                 1230             


Leu Ser  Thr Ile Gln Asn Ala  Asp Leu Ile Val Val  Phe Gln Asn 
    1235                 1240                 1245             


Gly Arg  Val Lys Glu His Gly  Thr His Gln Gln Leu  Leu Ala Gln 
    1250                 1255                 1260             


Lys Gly  Ile Tyr Phe Ser Met  Val Ser Val Gln Ala  Gly Thr Lys 
    1265                 1270                 1275             


Arg Gln  
    1280 


