                         SEQUENCE LISTING

<110>  Regents of the University of Minnesota
       Moriarity, Brenden
       Kluesner, Mitchell
       Webber, Beau
 
<120>  PROGRAMMABLE NUCLEASES AND BASE EDITORS FOR MODIFYING NUCLEIC 
       ACID DUPLEXES

<130>  920171.00327

<150>  US 62/757,282
<151>  2018-11-08

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  1226
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Arg Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Pro Glu Gly Met Ile Ser Glu Ser Leu Asp Asn 
    690                 695                 700                 


Leu Glu Ser Met Met Pro Asn Lys Val Arg Lys Ile Gly Glu Leu Val 
705                 710                 715                 720 


Arg Tyr Leu Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg 
                725                 730                 735     


Ser His Gly Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro 
            740                 745                 750         


Pro His Glu Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp 
        755                 760                 765             


Phe Pro Ala Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala 
    770                 775                 780                 


Ala Asp Ala Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu 
785                 790                 795                 800 


Arg Met Gly Phe Thr Glu Val Thr Pro Val Thr Gly Ala Ser Leu Arg 
                805                 810                 815     


Arg Thr Met Leu Leu Leu Ser Arg Ser Pro Glu Ala Gln Pro Lys Thr 
            820                 825                 830         


Leu Pro Leu Thr Gly Ser Thr Phe His Asp Gln Ile Ala Met Leu Ser 
        835                 840                 845             


His Arg Cys Phe Asn Thr Leu Thr Asn Ser Phe Gln Pro Ser Leu Leu 
    850                 855                 860                 


Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp Ser Glu Asp 
865                 870                 875                 880 


Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly 
                885                 890                 895     


Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu 
            900                 905                 910         


Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met 
        915                 920                 925             


Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys 
    930                 935                 940                 


Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr 
945                 950                 955                 960 


Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys 
                965                 970                 975     


Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe 
            980                 985                 990         


Glu Asn Pro Lys Gln Gly Lys Leu  Arg Thr Lys Val Glu  Asn Gly Glu 
        995                 1000                 1005             


Gly Thr  Ile Pro Val Glu Ser  Ser Asp Ile Val Pro  Thr Trp Asp 
    1010                 1015                 1020             


Gly Ile  Arg Leu Gly Glu Arg  Leu Arg Thr Met Ser  Cys Ser Asp 
    1025                 1030                 1035             


Lys Ile  Leu Arg Trp Asn Val  Leu Gly Leu Gln Gly  Ala Leu Leu 
    1040                 1045                 1050             


Thr His  Phe Leu Gln Pro Ile  Tyr Leu Lys Ser Val  Thr Leu Gly 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Gln Gly His  Leu Thr Arg Ala Ile  Cys Cys Arg 
    1070                 1075                 1080             


Val Thr  Arg Asp Gly Ser Ala  Phe Glu Asp Gly Leu  Arg His Pro 
    1085                 1090                 1095             


Phe Ile  Val Asn His Pro Lys  Val Gly Arg Val Ser  Ile Tyr Asp 
    1100                 1105                 1110             


Ser Lys  Arg Gln Ser Gly Lys  Thr Lys Glu Thr Ser  Val Asn Trp 
    1115                 1120                 1125             


Cys Leu  Ala Asp Gly Tyr Asp  Leu Glu Ile Leu Asp  Gly Thr Arg 
    1130                 1135                 1140             


Gly Thr  Val Asp Gly Pro Arg  Asn Glu Leu Ser Arg  Val Ser Lys 
    1145                 1150                 1155             


Lys Asn  Ile Phe Leu Leu Phe  Lys Lys Leu Cys Ser  Phe Arg Tyr 
    1160                 1165                 1170             


Arg Arg  Asp Leu Leu Arg Leu  Ser Tyr Gly Glu Ala  Lys Lys Ala 
    1175                 1180                 1185             


Ala Arg  Asp Tyr Glu Thr Ala  Lys Asn Tyr Phe Lys  Lys Gly Leu 
    1190                 1195                 1200             


Lys Asp  Met Gly Tyr Gly Asn  Trp Ile Ser Lys Pro  Gln Glu Glu 
    1205                 1210                 1215             


Lys Asn  Phe Tyr Leu Cys Pro  Val 
    1220                 1225     


<210>  2
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val 
1               5                   10                  15      


Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr 
            20                  25                  30          


Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys 
    50                  55                  60                  


Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys 
65                  70                  75                  80  


Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr 
                85                  90                  95      


Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser 
            100                 105                 110         


Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys 
        115                 120                 125             


Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln 
    130                 135                 140                 


Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser 
145                 150                 155                 160 


Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu 
                165                 170                 175     


Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val 
            180                 185                 190         


Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu 
        195                 200                 205             


Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val 
    210                 215                 220                 


Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu 
225                 230                 235                 240 


Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly 
                245                 250                 255     


Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln 
            260                 265                 270         


Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala 
        275                 280                 285             


Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr 
    290                 295                 300                 


Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro 
305                 310                 315                 320 


Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly 
                325                 330                 335     


Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu 
            340                 345                 350         


Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val 
        355                 360                 365             


Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser 
    370                 375                 380                 


Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg 
385                 390                 395                 400 


Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn 
                405                 410                 415     


Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly 
            420                 425                 430         


Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr 
        435                 440                 445             


Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu 
    450                 455                 460                 


Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His 
465                 470                 475                 480 


Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr 
                485                 490                 495     


Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro 
            500                 505                 510         


Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu 
        515                 520                 525             


Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly 
    530                 535                 540                 


Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile 
545                 550                 555                 560 


Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe 
                565                 570                 575     


Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His 
            580                 585                 590         


Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu 
        595                 600                 605             


Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile 
    610                 615                 620                 


Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val 
625                 630                 635                 640 


Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr 
                645                 650                 655     


Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu 
            660                 665                 670         


Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu 
        675                 680                 685             


Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala 
    690                 695                 700                 


Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile 
705                 710                 715                 720 


Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln 
                725                 730                 735     


Phe Ser Leu Thr Pro 
            740     


<210>  3
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val 
1               5                   10                  15      


Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr 
            20                  25                  30          


Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys 
    50                  55                  60                  


Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys 
65                  70                  75                  80  


Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr 
                85                  90                  95      


Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser 
            100                 105                 110         


Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys 
        115                 120                 125             


Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln 
    130                 135                 140                 


Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser 
145                 150                 155                 160 


Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu 
                165                 170                 175     


Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val 
            180                 185                 190         


Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu 
        195                 200                 205             


Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val 
    210                 215                 220                 


Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu 
225                 230                 235                 240 


Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly 
                245                 250                 255     


Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln 
            260                 265                 270         


Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala 
        275                 280                 285             


Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr 
    290                 295                 300                 


Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro 
305                 310                 315                 320 


Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly 
                325                 330                 335     


Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu 
            340                 345                 350         


Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val 
        355                 360                 365             


Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser 
    370                 375                 380                 


Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg 
385                 390                 395                 400 


Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn 
                405                 410                 415     


Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly 
            420                 425                 430         


Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr 
        435                 440                 445             


Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu 
    450                 455                 460                 


Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His 
465                 470                 475                 480 


Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr 
                485                 490                 495     


Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro 
            500                 505                 510         


Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Gln 
        515                 520                 525             


Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly 
    530                 535                 540                 


Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile 
545                 550                 555                 560 


Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe 
                565                 570                 575     


Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His 
            580                 585                 590         


Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu 
        595                 600                 605             


Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile 
    610                 615                 620                 


Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val 
625                 630                 635                 640 


Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr 
                645                 650                 655     


Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu 
            660                 665                 670         


Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu 
        675                 680                 685             


Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala 
    690                 695                 700                 


Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile 
705                 710                 715                 720 


Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln 
                725                 730                 735     


Phe Ser Leu Thr Pro 
            740     


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4
gtgaatgagg atgagtgatg                                                   20


<210>  5
<211>  7382
<212>  DNA
<213>  Mus musculus

<400>  5
gtgaaatgag gatggcaacg ccatcttctg cgccctctgt gcgcaacaca gagaaacgca       60

aaaacaaaaa grcttcatct aargctagyg tctccttygg agcacctagc cttctctctt      120

cggagagtga agatgaagtt maytayatga cccctcctga gcaggaagct cagcccggcr      180

ccctcgcggc ccttcatgct gatgggccgc acgccgggct ccccgtgacg cgaagtgatg      240

cacgcgtgct gatcttcaat gagtgggagg agaggaagaa gtccgagccg tggctacggc      300

tggacatgtc tgacaaggcc atcttccgcc gctaccctca tctgcgrcct aaggaagaca      360

aggcygatgc gccctccyat gcggaggacg ccatggatgc aagggagccy gtggtgggrt      420

ccatycttga gcaggatgac cayaagttct accactactc tgtctacatc ggcaacggta      480

tggtgatggg tgtcaacaac cccggcgccg ccgtttgcca ggctgtgatt gatgtggara      540

agctccacct ttggtggagg ccagtytggg aacctcgcca accyctcgac ccggctgagt      600

tgaggaagtg tgtyggcatg accgtcccyt acgtggccac cactgtcaat tgctaccagg      660

tctgctgctg gattgttggg atcaaggaca cctggctgaa gagrgcgaag atatccagag      720

attcgccctt ctacagcccy gtccaggact ggaacattga tccccaggag cccttcatcc      780

cgtccaagct caggatggtt tctgatggca tcytagtggc tctctcaacg gtgattggtc      840

ggccgatcaa gaacctgctg gcatcmgtga agccgctcaa cattctgaac atcgtgttga      900

gytgtgactg gactttctcg ggcatagtca acgccctgat cctccttgct gagctatttg      960

acatcttttg gactccccct gatgtcacca actggatgat ctccatcttt ggggaatggc     1020

aagccgaggg gcccttcgac cttgccctgg acgttgtgcc caccctgctt ggtgggattg     1080

gcatggcctt cggcctgacg tctgaracca tcgggcgtaa gctcgcttcc accaactcag     1140

ccctcaaggc cgcccaggag atgggcaagt ttgcaattga ggtyttcaag cagatcatgg     1200

catggatttg gccttctgag gacccggtgc ctgctctgct ttccaacatg gagcaggcgg     1260

tcatcaagaa tgagtgccag cttgagaacc agctcacagc catgttgcgg gatcgcaacg     1320

ctggggccga gttcctgaaa gcacttgatg aagaagaaca agaggtccgc aggattgcgg     1380

ccaagtgcgg gaactccgcc accacgggca ccaccaacgc cctactggct aggatyagca     1440

tggctcgtgc ggccttcgag aaggcccgcg ctgagcagac ctcccgggtt cgrcccgtgg     1500

tgatcatggt atctggcagg cccgggatcg ggaaaacctg tttctgtcaa aacctggcaa     1560

agaggattgc cgcctccctt ggrgatgaga cctcagtcgg catcatacca cgtgctgacg     1620

tggaccactg ggatgcctac aarggcgcta gggtggtcct ytgggatgat ttcggcatgg     1680

acaacgtggt gaaggacgct ctgcggctgc agatgcttgc tgacacatgc cccgtcacgc     1740

ttaactgtga cagaattgag aacaagggka agatgtttga ttcccaggtc atcatcatta     1800

ccaccaacca gcagacccca gtgccyctgg attatgtcaa cctggaggcg gtgtgccgcc     1860

gcatagattt cctggtctat gctgagagtc ctgtggtgga tgccgctcgg gccagatcac     1920

ctggcgatgt ggctgccgtt aargccgcca tgaggccaga ttacagccac atcaacttca     1980

ttctggcccc acagggtggm tttgaccggc agggtaatac cccctatggs aagggcgtca     2040

ccaagatcat cggcgccacc gcgctctgtg caagagcggt tgctctcgtc catgagcgcc     2100

atgatgactt tggccttcag aacaaggtct atgattttga tgctggcaag gtgaccgcct     2160

ttaaggccat ggcggctgat gccggcatyc cytggtacaa gatggcrgcr atyggctrya     2220

aggccatggg ctgcacctgt gtggaggagg ccatgaattt gctgaaggac tatgaggtgg     2280

ccccstgcca agtgatctac aayggggcca cctacaatgt cagctgyatc aarggggccc     2340

ccatggtwga gaagrtcaag gagccygagy tgcccaagac aytggtcaac tgtgtcagra     2400

gratcaagga ggcscgcctc cgytgctact gcaggatggc cacagatgtc atcacttcya     2460

tcytgcaggc ggctggracg gcyttctcta tytaccatca rattgagaag aaatctaggc     2520

cttcctttta ttgggaccac ggttacacct accgagatgg cccaggtgcc tttgacatct     2580

ttgaggatga caacgatgga tggtaccact ctgagrgcaa gaagggtaag aataagaaag     2640

gtcgggggcg gcctggtgty ttcaagtccc gtgggctcac ggatgaggag tacgatgagt     2700

tcaagaagcg ccgcgaatcc aagggcggca agtactccat tgatgactac ctcgctgacc     2760

gcgagcgaga agargagctc caggagcgag atgaggagga ggccattttc ggggacggct     2820

ttggcctgaa agccacgcgc cgctcccgta aggcagagag agccagactt ggcctggtct     2880

cgggtggtga catccgcgcc cgcaagccga ttgactggaa tgtagttggt ccctcctggg     2940

ccgacgatga tcgccaggtc gattacggtg agaagatcaa ctttgaggcc ccagtctcca     3000

tctggtcccg tgttgtccaa ttcggcacgg ggtggggctt ctgggtcagt ggccatgtgt     3060

tcatcachgc caagcacgtg gcaccaccca agggcacgga ggtctttggt cgtaagcccg     3120

aggaattcac tgtcacctcc agtggggatt tcctdaaata ccatttcacc agtgccgtca     3180

ggcctgacat ccctgccatg gttctggaga acggctgcca ggagggcgtt gttgcctcag     3240

tcctcgtcaa gagggcttcc ggcgagatgc tcgctctggc ggtcaggatg ggctcacagg     3300

ctgccatcaa gatcggcaac gctgtggtgc atgggcagac cggcatgctc ttaactgggt     3360

ccaatgccaa ggcccaagac ctcgggacta tcccgggtga ctgtggttgc ccctatgttt     3420

acaagaaggg aaacacctgg gttgtgattg gggtgcatgt ggcggctact agatcaggca     3480

acaccgtcat tgccgccacc catggtgagc ccacacttga ggccctagaa ttccaggggc     3540

ccccaatgct cccccgcccc tctggcacct atgctggcct ccccatcgcc gactatggcg     3600

acgcccctcc cttgagcacc aagaccatgt tctggcgcac ctcgccagag aagctccccc     3660

ctggagcctg ggagccagcc taccttggct ccaaggatga gagggtggac ggcccttcct     3720

tacagcaggt catgagagac caactcaagc cctactcaga gccacgtggc ctgctccctc     3780

cycaggaaat tctggacgcg gtttgtgatg ccatcgagaa ccgccttgag aacacccttg     3840

agccgcagaa gccctggaca ttcaagaagg cctgygagag yctkgacaag aayaccagca     3900

gtggrtaccc ctaycacaar cagaaragca aggactggac gggraccgcc ttcatyggcg     3960

agctcggtga ccaggcyacy catgccaaca acatgtatga gatgggtaag tccatgcggc     4020

ccgtctacac agctgccctc aaggatgagc tggtcaagcc agacaagatc tacaagaaga     4080

taaagaagag gttgctctgg ggctctgacc ttggcaccat gattcgcgcc gcccgcgctt     4140

ttggcccctt ctgtgatgcc ctgaaagaga cttgtgttct taatcctgty agagtgggta     4200

tgtcgatgaa cgaagatggc cccttcatct tcgcgaggca cgccaayttc agrtaccaca     4260

tggatgcaga ttacaccaga tgggactcca cccagcagag ggcyatcttg aagcgcgccg     4320

gtgacatcat ggtgcgtctc tcccctgagc cagagttggc tcgggtggtg atggatgacc     4380

tcctggcccc ctcgctgctg gacgtcggcg actataagat cgtcgtcgaa gaggggctcc     4440

cgtccgggtg cccctgcacc acgcagctga ayagtctggc ccattggatc ctgacccttt     4500

gtgcaatggt tgaagtgacc cgwgttgacc ccgayatygt gatgcargar tctgaattct     4560

ccttctatgg tgatgacgag gtggtctcga ccaacctcga attggatatg accaaataca     4620

ccatggccct gaagcggtac ggtcttctcc cgacccgtgc ggacaaggag gagggccccc     4680

tggagcgtcg ccagacgctg cagggcatct ccttcctgcg ccgcgcaata gtcggtgacc     4740

agtttggctg gtatggtcgc ctcgaccgtg ctagcattga ccgccagctt ctttggacwa     4800

aaggacccaa tcaccaraac ccytttgaga ctctcccagg acatgctcag agaccctccc     4860

aattgatggc cctgcttggt gaggctgcca tgcatggtga aaagtactay aggactgtgg     4920

cttcccgggt ctccaaggag gccgcccaga gtgggataga aatggtggtc ccacgccacc     4980

ggtctgttct gcgctgggtg cgctttggaa caatggatgc tgagaccccg caggaacgct     5040

cagcagtctt tgtgaatgag gatgagtgat ggcgcagcgc caaaagccaa cggctctgaa     5100

gccagcggcc aggatcttgt tcctaccgcc gttgaacagg ccgtccccat tcagcccgtg     5160

gctggcgcgg ctcttgccgc ccccgccgcc gggcaaatca accaaattga cccctggatc     5220

ttccaaaatt ttgtccaatg cccccttggt gagttttcca tttcacctcg aaacacccca     5280

ggtgaaatac tgtttgattt ggccctcggg ccagggctca acccctacct cgcccacctc     5340

tcagccatgt acaccggctg ggttgggaac atggaggttc agctggtcct cgccggcaat     5400

gcctttactg ctggcaaggt ggttgttgcc cttgtaccac cctattttcc caaagggtca     5460

ctcaccactg ctcagatcac atgcttccca catgtcatgt gtgatgtgcg caccctggag     5520

cccattcaac tscctcttct tgacgtgcgt cgagttcttt ggcatgctac ccaggatcag     5580

gaggaatcta tgcgcctggt ctgcatgctg tacacgccac tccgcacaaa cagcccgggt     5640

gatgagtctt ttgtggtctc tggccgcctt ctttctaagc cggcggctga tttcaatttt     5700

gtatacctga ccccccccat tgagagaacc atctaccgga tggtcgactt gcccgtgttg     5760

cagccgcggc tgtgcacgca tgctcgttgg ccagccccga tttatggcct cctggtggac     5820

ccatccctcc cgtccaaycc ccaatggcag aatggtagag tgcatgttga tggaaccctc     5880

ctcggtacga cacctgtctc tgggtcctgg gtttcctgct ttgcggctga agctgcctay     5940

gagtttcagt ctggcattgg tgaggtggca actttcaccc tgattgagca ggatggctct     6000

gcctatgtcc ctggtgacag ggcagcaccc cttggctacc ccgatttctc cgggcaactg     6060

gagattgagg tgcagactga gaccaccaaa gcaggtgaca agctgaaggt gaccacctty     6120

gagatggtcc ttggccccac caccaacgtg gatcaagcgc cctaccaggg cagggtgtac     6180

gcyagcctaa cggctgygtc ctccctcgat ctggtggatg gcagggttag ggcggttcca     6240

cgctctgtct ttggcttcca agatgtggtt cctgagtata atgatggcct ccttgtcccc     6300

cttgcccccc caatyggccc cttycttcct ggtgaggtgc ttctgaggtt ccggacctac     6360

atgcgtcagg ttgacagctc tgacgccgct gcggaagcca tcgactgcgc ccttccacag     6420

gaattcgtct cgtggtttgc gagtaacgga ttcacggtgc agtcggaggc cctgctcctt     6480

aggtacagga acaccctaac agggcagctg ctgtttgagt gcaagctcta cagcgaaggc     6540

tacatcgccc tgtcctatcc gggctcagga ccgctcacct tcccgactga tggcttcttc     6600

gaggttgtca gttgggtccc ccgcctttat caattggcct ctgtgggaag cttggcaaca     6660

ggccgaacac tcaaacaata atggctggtg ccctctttgg agcaattgga ggtggcctga     6720

tgggtataat tggcaattcc atctcaaatg ttcaaaacct tcaggcaaat aaacaattgg     6780

ctgctcagca atttggttay aattcttctt tgcttgcaac gcaaattcag gcccagaagg     6840

atctcactct gatggggcag caattcaacc agcagctcca agccaactct ttcaagcacg     6900

acttggaaat gctcggcgcc caggtgcaag cccaggcgca ggcccagrag aatgccatca     6960

acatcaaatc ggcacaactc caggccgcgg gcttttcaaa gtctgacgcc attcgcctgg     7020

cctcggggca gcaaccgacg agggccgtcg actggtcggg gacgcggtat tacaccgcca     7080

accagccggt cacgggcttc tcgggtggct tyaccccaag ttacactcca ggtaggcaaa     7140

tggcagtccg ccctgtggac acatcccctc taccggtctc aggtgggcgc atgccgtccc     7200

ttcgtggagg ttcctggtct ccgcgtgact acacgccaca gactcaaggc acctacacga     7260

acggtcggtt cgygtccttc ccraagatcg ggagtagcag ggcgtaggtt ggaagagaaa     7320

cctttctgtg aaaatgattt ctgcttactg ctcttttctt ttggtagtat ttagatgcat     7380

tt                                                                    7382


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6
gugaaugaug auggcgucga                                                   20


<210>  7
<211>  7710
<212>  DNA
<213>  Norovirus GI isolate NORO_79_05_07_2014

<400>  7
gtgaatgatg atggcgtcga aagacgtcgt tgcaactaat gttgcaagca acaacaatgc       60

taacaacact agtgctacat ctcggttctt atcgagattt aagggcttag gaggcggcgc      120

aagcccccct agccctataa aaattaaaag tacagaaatg gctctggggt taattggcag      180

aacgacccca gaatcaacgg ggaccgctgg cccaccgccc aaacaacaga gagaccgacc      240

tcctagaact caggaggagg tccagtacgg tatggggtgg tctgacaggc ccattgacca      300

gaacgtcaaa tcatgggaag agcttgacac cacagttaag gaagagatcc tagacaacca      360

caaagaatgg tttgacgctg gtggtttggg tccttgcaca atgcctccaa catatgaacg      420

ggtcagggat gacagtccgc ctggtgaaca ggttaaatgg tccgcacgtg atggagtcaa      480

cattggagtg gaacgcctca caacagtgag tgggcctgag tggaatcttt gccccttacc      540

ccccattgat ttgaggaaca tggaaccagc tagtgaaccc actattggag atatgataga      600

attctacgaa ggccacatct atcattactc catatacatt gggcaaggta agacagtcgg      660

cgtccattct ccacaggcgg cattttcagt ggctagagtg accatccagc ccatagccgc      720

ttggtggaga gtttgttaca taccccaacc caagcataga ctgagttacg accaactcaa      780

ggaactagag aatgagccat ggccatacgc ggccataact aataattgtt ttgaattctg      840

ctgtcaagtc atgaaccttg aggacacgtg gttgcaaagg cgactggtca cgtcgggcag      900

attccaccac cccacccagt cgtggtcaca gcagacccct gagttccaac aagatagcaa      960

gttagagttg gttagggacg ccatattggc tgcagtgaat ggtcttgttt cgcagccctt     1020

taagaacttc ttgggtaaac tcaaacccct caatgtgctt aacatcctgt ctaactgtga     1080

ttggaccttc atgggggtgg tggaaatggt catactatta cttgaactct ttggtgtgtt     1140

ctggaacccg cctgatgtat ccaattttat agcgtccctt cttcctgatt tccatcttca     1200

gggacctgaa gacttggcac gagatctagt cccagtgatt cttggtggta taggattggc     1260

cattgggttc accagagaca aagttacaaa gatcatgaag agtgctgtgg atggtcttcg     1320

agctgctaca caactgggac agtatggatt agaaatattc tcactgctca agaagtactt     1380

ctttgggggg gaccagactg agcgcaccct caaaggcatt gaggcagcag tcatagatat     1440

ggaggtactg tcctccactt cagtgacaca gctagtgagg gacaaacagg cagcaaaggc     1500

ctatatgaac atcttggaca atgaagaaga gaaggccagg aagctctctg ctaaaaacgc     1560

tgacccacat gtgatatcct caacaaatgc cctaatatcg cgcatatcca tggcacgatc     1620

tgcattggcc aaggcccagg ctgagatgac cagtcgaatg cgaccagttg tcattatgat     1680

gtgtggtcca cctgggattg ggaagaccaa ggctgctgag cacctagcta agcgtctagc     1740

caatgagatc agaccaggtg gtaaggtggg gttggttccc cgtgaagctg tcgaccactg     1800

ggacggctat catggtgagg aagtgatgct gtgggatgac tatggcatga caaaaataca     1860

agacgactgt aataaactcc aggccattgc tgattcggcc cccctcacat taaattgtga     1920

taggattgaa aataaaggaa tgcagttcgt ttcagatgca atagtcatca ccaccaacgc     1980

cccaggcccc gcccctgtgg actttgtcaa ccttggacca gtgtgtagac gggtcgactt     2040

tttggtgtac tgctctgccc cagaggtgga gcagatacgg agagtcagcc ctggcgacac     2100

atcagcactg aaagactgct tcaagccaga tttctcacat ttaaaaatgg agctggctcc     2160

acaaggtggg ttcgataatc aagggaacac accgtttggc aggggcacca tgaagccaac     2220

aaccattaat agactcctca tacaagccgt ggcccttacc atggaaaggc aggatgagtt     2280

ccagttgcag ggaaagatgt atgactttga tgatgacagg gtgtcagcgt tcaccaccat     2340

ggcacgtgac aatggcctgg gcatcttgag catggcgggt ctaggtaaga agctacgcgg     2400

tgtcacaacg atggagggct tgaagaatgc cctgaaggga tacaaaatta gtgcgtgcac     2460

aataaaatgg caggctaaag tgtactcact agagtcagat ggcaacagtg tcaacattaa     2520

agaggagagg aacatcttaa ctcaacaaca acagtcagtg tgtgctgcct ctgttgcgct     2580

cactcgcctc cgggctgcgc gtgcggtggc atacgcgtca tgcatccaat cggctataac     2640

ctctatacta caaattgctg gctcggccct agtggtcaac agagcagtga agagaatgtt     2700

tggcacgcgt actgccaccc tgtcccttga gggccccccc agagaacaca agtgcagggt     2760

ccacatggcc aaggccgcag gaaaggggcc tattggccat gatgatgtgg tagaaaagta     2820

tgggctttgc gaaactgagg aggacgaaga agtggcccac actgaaatcc cttctgccac     2880

catggagggc aagaataaag ggaagaacaa gaaaggacgt ggtcggaaga acaactacaa     2940

cgccttctcc cgcaggggac tcaatgatga agagtacgaa gagtacaaga agatacgcga     3000

ggagaaaggt ggcaattata gcatacagga gtacctagag gataggcaaa ggtatgaaga     3060

agagctagca gaggttcaag caggtggaga tggaggaatc ggggaaactg aaatggaaat     3120

ccgccacaga gtgttctaca aatctaagag tagaaagcat caccaggaag agcgacgcca     3180

gctagggctg gtaacaggtt ccgacattcg gaagagaaaa ccaatcgact ggaccccacc     3240

caagtcagca tgggcagatg atgagcgtga ggtggattac aatgagaaga tcagttttga     3300

ggcgcccccc actttatgga gcagagtgac aaagtttggg tctggatggg gtttctgggt     3360

cagctctaca gtcttcataa ccacaacgca cgtcatacca accagtgcga aggaattctt     3420

tggtgaaccc ctaaccagca tagccatcca cagggctggt gagttcactc tattcaggtt     3480

ctcaaagaaa attaggcctg acctcacagg tatgatcctt gaggagggtt gccccgaggg     3540

cacagtgtgt tcagtactaa taaaaaggga ctctggtgaa ctactgccat tggctgtaag     3600

aatgggcgca atagcatcaa tgcgtataca gggccgcctt gtccatgggc agtccggcat     3660

gttgctcacc ggggccaatg ctaagggcat ggaccttgga accatcccag gagactgtgg     3720

ggctccttat gtctataaga gagccaacga ctgggtggtc tgtggtgtac acgctgctgc     3780

caccaaatca ggcaacaccg ttgtgtgcgc cgttcaggcc agtgaaggag aaaccacgct     3840

tgaaggcggt gacaaaggtc attatgctgg acatgaaata attaagcatg gttgtggacc     3900

agccctgtca accaaaacca aattctggaa atcatccccc gaaccactac cccctggggt     3960

ctatgaaccc gcctacctcg ggggccggga ccctagggta actggcggtc cctcactcca     4020

acaggtgttg cgggaccagt taaagccatt tgctgagcca cgaggacgca tgccagagcc     4080

aggtctcttg gaggccgcag ttgagactgt gacttcatca ttagagcagg ttatggacac     4140

tcccgttcct tggagctata gtgatgcgtg ccagtccctt gataagacca ctagttctgg     4200

ttttccctac cacagaagga agaatgacga ctggaatggc accaccttta tcagggagtt     4260

aggggagcag gcagcacacg ctaataacat gtatgaacag gctaaaagta tgaaacccat     4320

gtacacggca gcacttaaag atgaactagt caaaccagag aaggtatacc aaaaagtgaa     4380

gaagcgcttg ttatgggggg cagacttggg cacggtggtt cgggccgcgc gggcttttgg     4440

tccattctgt gatgctataa aatcccacac aatcaaattg cccattaaag ttggaatgaa     4500

ttcaattgag gatgggccac tgatctatgc agaacattca aagtataagt accattttga     4560

tgcagattac acagcttggg attcaactca aaatagacaa atcatgacag agtcattctc     4620

aatcatgtgt cggctaactg catcacctga actagcttca gtggtggctc aagatttgct     4680

tgcaccctca gagatggatg ttggcgacta tgtcataaga gtgaaggaag gcctcccatc     4740

tggttttcca tgtacatcac aggttaatag tataaaccat tggttaataa ctctgtgtgc     4800

cctttctgaa gtaactggtc tgtcgccaga tgtcatccag tccatgtcat atttctcttt     4860

ctatggtgat gatgaaatag tgtcaactga catagaattt gatccagcaa aactgacaca     4920

agtcctcaga gagtatggac ttaaacccac ccgccccgac aaaagcgagg gcccaataat     4980

tgtgaggaag agtgtggatg gtttagtctt tttgcgtcgc actatctccc gcgacgccgc     5040

aggattccag gggcgactgg accgggcatc cattgaaagg caaatctact ggactagagg     5100

acccaaccac tcagaccctt ttgagaccct ggtgccacat caacaaagga aggtccaact     5160

aatatcatta ttgggtgagg cctcactgca tggtgaaaag ttttacagga agatttcaag     5220

taaagtcatc caggagatta aaacaggggg ccttgaaatg tatgtgccag gatggcaagc     5280

catgttccgt tggatgcggt tccatgacct tggtttgtgg acaggagatc gcaatctcct     5340

gcccgaattt gtaaatgatg atggcgtcta aggacgcccc tcaaagcgct gatggcgcaa     5400

gcggcgcagg tcaactggtg ccggaggtta atacagctga ccccttaccc atggaacctg     5460

tggctgggcc aacaacagcc gtagccactg ctgggcaagt taatatgatt gatccctgga     5520

ttgttaataa ttttgtccag tcacctcaag gtgagttcac aatctctcct aacaataccc     5580

ccggtgatat tttgtttgat ttacaattag gtccacatct aaaccctttc ttgtcacatt     5640

tgtcccaaat gtataatggc tgggttggga acatgagagt cagaattctc cttgctggga     5700

atgcattctc agctggaaag attatagttt gttgtgtccc ccctggcttt acatcttctt     5760

ctctcaccat agctcaggcc acattgtttc cccatgtaat tgctgatgtg agaacccttg     5820

agccaataga aatgcccctc gaggatgtac gcaatgtcct ctatcacacc aatgataatc     5880

aaccaacaat gcggttggtg tgtatgctat acacgccgct ccgcactggt ggggggtctg     5940

gtaattctga ttcctttgta gttgctggca gggttctcac agcccctagt agcgacttta     6000

gtttcttgtt ccttgtcccg cctaccatag agcagaagac tcgggctttc actgtgccta     6060

atatcccctt gcaaaccttg tccaattcta ggtttccttc cctcatccag gggatgattc     6120

tgtcccccga tgcatctcaa gtggtccaat tccaaaatgg gcgctgcctt atagatggtc     6180

aactcctagg cactacaccc gctacatcag gacagctgtt cagagtaaga ggaaagataa     6240

atcagggagc ccgcacactt aacctcacag aggtggatgg taaaccattc atggcatttg     6300

attcccctgc acctgtgggg ttccccgatt ttggaaaatg tgattggcat atgagaatca     6360

gcaaaacccc aaacaacaca agttcaggtg accccatgcg cagtgtcagc gtgcaaacca     6420

atgtgcaggg ttttgtgcca cacctgggaa gtatacaatt tgatgaagtg tttaaccatc     6480

ccacaggtga ctacattggc accattgaat ggatttccca gccatctaca ccccctggaa     6540

cagatattga tctgtgggag atccccgatt atggatcatc cctttcccaa gcagctaatc     6600

tggccccccc agtattcccc cctggatttg gtgaggccct tgtgtacttt gtttctgctt     6660

tcccgggccc caataaccgc tcagccccga atgatgtacc ctgtcttctc cctcaagagt     6720

acataaccca ctttgtcagt gaacaagccc caacgatggg tgacgcagcc ttactgcatt     6780

atgtcgaccc tgataccaac aggaaccttg gggagttcaa gctataccct ggaggttacc     6840

tcacctgtgt accaaatggg gtaggtgccg ggcctcaaca gcttcctctt aatggtgttt     6900

ttctctttgt ttcttgggtg tctcgttttt atcagcttaa gcctgtggga acagccagta     6960

cggcaagagg taggcttgga gtgcgccgta tataatggcc caagccatca taggagcaat     7020

tgccgcgtca gctgcaggct cagcattggg tgcgggcatc caggctggtg ccgaggctgc     7080

gcttcagagt caaagatacc aacaagactt agccctgcaa aggaatactt ttgaacatga     7140

caaggatatg ctttcctacc aggtccaggc aagtaatgca cttttggcaa agaatctcaa     7200

tacccgctat tctatgcttg ttgcaggggg tctttctagt gctgatgctt ctcgggctgt     7260

tgctggggcc cctgtaacac aattgattga ttggaacggc actcgggttg ccgcccccag     7320

atcaagtgca acaactctga ggtctggtgg tttcatggca gtccccatgc ctgttcaatc     7380

caaatctaag gccctgcaat cctctgggtt ttctaatcct gcttatgaca cgtccacagt     7440

ttcttctagg acttcttctt gggtgcagtc acagaattcc ctgcgaagtg tgtcaccctt     7500

tcataggcag gcccttcaaa ctgtatgggt tactccacct gggtctactt cctcttcttc     7560

tgtttcctca acaccttatg gtgtttttaa tacggatagg atgccgctat tcgcaaattt     7620

gcggcgttaa tgttgtaata taatgcagca gtgggcacta tattcaattt ggtttaatta     7680

gtgaataatt tggccattga ttagtgttaa                                      7710


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8
guaaaagaaa uuugagacaa                                                   20


<210>  9
<211>  7685
<212>  DNA
<213>  Feline calicivirus strain GX01-13

<400>  9
atgtctcaaa ctctgagctt cgtgctaaaa acccacagtg tccgtaagga ctttgtgcac       60

tccgtcaagt taacacttgc tcggaggcgc gatcttcagt atctttataa caagcttgcc      120

cgctctatac gagcggaggc ttgtccatct tgtgctagtt acgacgtttg tcctaactgc      180

acctctagtg acattcccga tgatggttcg tcaacaaact cgattccatc ttgggatgac      240

gtcacgaaaa cttcaaccta ttccctctta ctctccgagg atacatctga tgagcttagc      300

cctgatgatt tggttaacat tgcttcccac atccgtaagg caatatcctc tcagtcgcat      360

cctgccaaca atgagatgtg caaagaacag ctcacctcgt tgctgacagt ggctgaggcc      420

atgttgcccc aacgatcgcg gtcaacaatc ccactgcatc agaaacacca ggcagctcga      480

ttggaatgga gagaaaaatt cttttctaaa cctcttgact tcctccttga gaaacttggc      540

atgtctaagg acattctaca aaccactgct atttggaaga ttgttttgga aaaggcctgc      600

tactgtaaat cttatggtga acaatggttt aatgctgcaa aggcaaagct ccgtgagatc      660

aaggaattcg agggaagtac tttaaaacct ttaattggtg cgtttattga cggactgcgg      720

ctcatgaccg tcgataatcc aaaccctatt ggcttcttgc caaaattaat tggcttagtt      780

aaacctctaa atttggcaat gataattgac aaccatgaaa ataccatgtc aggatgggtt      840

gtaaccctca cagcaatcat ggagctgtac aacattactg agtgtacaat tgatgtgatt      900

acggcgctga tcactggatt ctatgacaaa ttggcaaaag ctaccaaatt ttatagtcag      960

gttaaagctt tattcactgg atttagatca gaggaagtgt caaattcatt ttggtacatg     1020

gcagctgcag tattgtgcta ccttatcact ggcttgctac caaacaatgg caggctttca     1080

aaaatcaagg cctgtttgtc tggtgcttcg acgctagtat ctggtataat tgccacacaa     1140

aagcttgctg caatgtttgc cacttggaac tccgaaacaa tagttaatga actttcagcc     1200

aggactgttg cgctttcgga gcttaacaac cccaccacga catccgacac tgactcagta     1260

gaaagactac tagaattggc taagatctta catgaagaaa tcaaagttca cacgttgaat     1320

ccaattatgc aatcatacaa cccaattctc agaaatttga tgtcaacatt ggatggtgtc     1380

atcacatcat gcaacaaacg aaaagccatt gctaagaaga gacctgttcc agtatgttat     1440

atactaactg gtccaccagg ttgtgggaaa acaacagctg ctttagcatt ggcaaagaag     1500

ttgtcagaac aagagccatc tgttataaat ttggatgtag atcaccatga cacatacact     1560

ggcaacgaag tctgcatcat tgatgaattt gattcgtctg acaaggtcga ttatgcaaat     1620

tttgttattg ggatggttaa ttcggcaccc atggtcttaa attgtgacat gcttgaaaac     1680

aaggggaagc tctttacctc taaatatatt ataatgacct ctaattctga aactcctgtt     1740

aagcccggtt caaagcgtgc cggtgcattc tatcgaaggg tcacaatcat tgatgtcaca     1800

aaccctttgg tagagtcaca caagcgcgcc agacctggca cctctgttcc tcgcagttgc     1860

tataagaaaa acttctctca tctgtcgctt gctaagcgtg gggctgagtg ttggagcaag     1920

gagtatgtcc ttgaccccaa gggactccag catcaaagca ttaaggcccc tccgcccacc     1980

ttccttaata ttgattctct tgctcaaaca atgatacaag atttcacact aaagaacatg     2040

gcatttgagg cagaggaagg atgcagtgat caccggtatg ggtttatctg ccagaaggag     2100

gaagtggaaa cagttcgcag acttcttaat gcaattaggg ttaggctcaa tgcaactttc     2160

acagtctgtg tagggcctga agcatctagt tcagtgggat gtaccgctca cgtcttaaca     2220

ccagatgagc cgttcaatgg taaaagattt gtggtttctc gctgtaatga ggcgtcacta     2280

tctgcattag aaggcaactg tgtccaaacc gcattgggtg tgtgcatgtc caacaaggat     2340

ctaacccatt tgtgtcattt cataaggggg aagattgtca atgatagtgt cagactggat     2400

gaactacccg ctaatcaaca tgtggtaacc gttaactcgg tgtttgattt agcctgggct     2460

cttcgccgtc acctgtcact atctggacag ttccaagcca tcagagccgc atatgatgtg     2520

cttactgtcc ccgataaaat ccctgcaatg ttaagacact ggatggatga gacttcattc     2580

tctgatgaac atgtcgtaac ccaattcgta acccctggtg gtatagtgat tcttgaatca     2640

tgtgttggtg ctcgcatctg ggccattggt cacaatgtga tcagggctgg aggtatcacc     2700

gccacaccga ctgggggttg cgtgagatta atgggattgt cggctcatac tatgccatgg     2760

agtgaaatct ttagggaact cttctctctt ctggggaaaa tctggtctag tgttaaagtc     2820

tccactctag ttctcaccgc tcttggaatg tacgcatcaa gattcagacc aaaatcagag     2880

gcaaaaggca agacaaagag caaaattggc ccctacagag gtcgtggcgt tgcccttacc     2940

gacgacgagt atgatgaatg gagggaacac aatgccacta gaaaattgga cttatctgtt     3000

gaagattttc taatgctaag gcatcgcgca gcacttggtg ctgatgatgc tgatgctgtc     3060

aaattcaggt cttggtggag ctctagatca agacttgctg atgatataga agatgtcacc     3120

gtaattggca agggtggcgt taaacatgag aaaattagaa caaacactct aagagccgtt     3180

gatcgtggct acgatgtcag ctttgctgaa gaatctggcc ctggaaccaa atttcacaag     3240

aatgcaattg gctctgtcac tgatgcttgt ggtgaacaca agggatactg tatccatatg     3300

ggtcatggtg tttacgcttc tgttgcccat gtggtgaaag gtgattcatt ctttcttggt     3360

gagaggatct ttgacttgaa aactaatggt gaattctgtt gctttagaag cacaagggta     3420

ctcccaagtg cagctccttt cttttctgga aaacccacac gtgacccatg gggctctcct     3480

gttgctacag agtggaagcc aaagccctac acaacaacat ctgggaaaat tgtagggtgc     3540

ttcgcaacta catcaactga aacccaccct ggtgattgtg gcctgccgta catcgatgat     3600

tgtggaagag ttacagggct acatacagga tctggaggcc caaagacccc tagtgcaaaa     3660

ttaattgttc catatgtcca cattgatatg aaggccaaat ctgtcactcc ccaaaagtat     3720

gatgttacaa aacctgacat cagctataaa ggtttaattt gcaaacaatt ggacgaaatc     3780

agaattatac caaagggaac ccggcttcac gtatctcctg ctcacgttga tgactacgaa     3840

gaatgctctc accaaccagc atccctcggt agtggtgatc cccgatgtcc aaaatctctg     3900

acagctattg ttgttgattc cttaaaacct tactgtgata aagtggaagg ccctcctcat     3960

gatatattgc acagagtcca gaaaatgctg attgatcacc tgtctggatt cgtccccatg     4020

aacatatcct ctgaaacttc tatgctatcc gcatttcaca aattgaatca tgacacatct     4080

tgtggacctt acttaggtgg aaggaagaaa gatcatatgg taaatggtga acctgacaaa     4140

gctctcttgg atctcctatc ctcaaaatgg aaattggcaa cacaagggat ttccctccca     4200

cacgagtaca caattggttt gaaagacgag ctgagaccag tggagaaagt cgctgaggga     4260

aagaggagga tgatctgggg gtgtgatgtc ggtgttgcta ctgtgtgtgc tgctgctttc     4320

aaagctgtta gtgatgcaat cacagcaaat catcaatatg ggcctattca agttggtatc     4380

aatatggata gtcccagtgt tgaggcgctg taccaacgga tcaagagctt tgccaaagtc     4440

tttgcagttg attactccaa atgggattcg actcaatcgc cccgtgtaag tgctgcctca     4500

attgacatcc tgcgatactt ctctgacaga tcaccaattg ttgattcggc cacaaataca     4560

cttaaaagcc caccagttgc tatttttaat ggagttgctg ttaaggtcac atctggtttg     4620

ccctccgaaa tgcccctcac ctctgtgatt aactctctta accactgttt gtatgttggg     4680

tgtgctatcg ttcaatcttt agaggctagg aatgtccctg tcacatggaa tttgttctcc     4740

tcttttgaca tgatgactta tggtgatgat ggtgtgtata tgtttccaat gatgtttgct     4800

agtgttagtg accaaatctt tggtaacctt tctgcttacg gcctaaaacc aacccgagtt     4860

gacaagaccg ttggggctat tgagccaatt gaccctgagt cagttgtctt tctaaaaaga     4920

acaatctcta gaactcccca tggtgtccga ggattgttgg atcgcagttc aataattagg     4980

cagttttact acatcaaagg tgaaaacaca gatgattgga aaaccccccc aaaaacaatc     5040

gatccaacat cccgtggtca gcaactctgg aatgcctgct tgtatgctag tcaacatgga     5100

agtgagttct acaacaagat ttacaaattg gctgtgaagg ctgttgagta cgaaggactc     5160

caccttgacc ctccttctta cagttcggct ttggaacatt acaacagcca gttcaatggc     5220

gtggaggcgc ggtccgatca gatcaatatg agtgatggta ccgccctaca ctgtgatgtg     5280

ttcgaagttt gagcatgtgc tcaacctgcg ctaacgtgct aaaatactat gattgggacc     5340

cccactttag attggttatt aaccccaaca aattcttacc cgttggtttc tgcaataacc     5400

ctcttatgtg ttgttaccct gaattgcttc ctgaatttgg aactgtgtgg gactgtgatc     5460

aatccccact tcaaatctac ctagagtcaa tccttggtga tgatgagtgg tcttcaacct     5520

atgaagcaat tgaccctgtt gtgccaccaa tgcactggga cgaagctggt aagatcttcc     5580

agccacaccc tggtgtacta atgcaccaca tcattggtga agtcgcaaag gcatgggatc     5640

cgaatctgcc tcttttccga cttgaggcag acgacagttc cgtaacaacg cctgaacagg     5700

gcaccgctgt tggtggtgtg attgctgagc ccaatgcaca gatggcagcg gccgctgata     5760

cggctactgg gaaaagtgtc gactcagaat gggagaattt cttctcattc cacaccagtg     5820

tgaattggag cacttctgaa acccaaggaa agattctgtt taaacaatca cttggtcctc     5880

ttctaaaccc ttatctggaa catttgtcta agctatatgt tgcttggtct gggtctatcg     5940

aagttagatt ttctatctct ggttctggtg tctttggggg gaagctcgcg gctattgtcg     6000

taccgccggg gattaatccc gtggcgagca cttcaatgct gcaatacccg catgtcctat     6060

ttgatgctcg tcaagtagaa cctgtcattt ttactattcc tgatcttagg aactcgcttt     6120

accacttaat gtctgatact gacactacat ccttggttat tatgatctat aatgatttga     6180

ttaaccctta tgctaatgat tctaactcct ctggatgcat tgtcacagta gagactaagc     6240

ctggacctga cttcaaattt cacctcttga aaccacctgg ctcaatgtta acacatggtt     6300

ctgtaccgtc agatttgatt ccaaaatcat cctcactatg gattggcaac cgctattggt     6360

ctgacatcac cgatttcatt gttcgtccat ttgtgttcca ggcaaatcgt cactttgact     6420

ttaatcaaga gacagctggt tggagtactc caagatttcg gcccattagt attaccatca     6480

gtcaaaaaga cggtgcaaaa cttggcactg ggattgccac tgatttcatt gtacctggaa     6540

taccagacgg atggccagac acaacaattg cagaagaact catccccgct ggtgactatg     6600

ccatcacaaa ttcagccaat aatgatattg ccacaaaggc tgcttacgag gcagcagatg     6660

ttatcaagaa caacaccaac tttagaggta tgtacatttg tggcgctctt caaagagctt     6720

ggggagacaa gaaaatttcc aatactgctt tcatcaccac cgctacaatc agtaataact     6780

ccatcaagcc ctgtaacaaa attgatcaaa caaagattac tgtgttccaa aacaaccatg     6840

ttggtagtga tgtacaaaca tctgatgaca cactagcctt gcttggttat acggggattg     6900

gagaagaagc cattggggcg aatagggaga aagttgttcg catcagtgtt ttgcgtgagg     6960

ctggtgcacg cggcgggaat caccctatat tttacaaaaa ctccattaaa ttaggctatg     7020

taattggatc tattgatgtg ttcaattctc aaatcttgca cacgtctagg caattgtctc     7080

ttaaccatta tctgttggct cctgactctt ttgctgttta taggattatt gactctaatg     7140

gttcttggtt tgacataggt attgattctg atggattctc ctttgttggt gtttctacca     7200

ttcctccgct agagtttcca ctttctgcct ccttcatggg aatacaattg gcaaagattc     7260

gacttgcctc aaacattagg agtgctatga caaaattatg aattcaatat taggccttat     7320

tgactctgta actaacacag taagtaaagc acaacaaatt gaattagata aagctgcact     7380

tggtcaaaat agagaacttg ctttaaaacg tattaacttg gatcagcaag ctcttaataa     7440

ccaggtgtcg caatttaaca aacttcttga gcagagggta cagggcccta ttcagtcagt     7500

tcgattagct cgtgctgctg gattccgggt tgacccttac tcatacacaa atcaaaattt     7560

ttatgatgac caactcaatg caattagatt atcatataga aatttgttta aaatgtagaa     7620

tgaattttat aatttggatt gattggatgt acctcttcgg gctgtcgctg cgcctaaccc     7680

caggg                                                                 7685


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10
gugaucguga uggcuaauug                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11
gugaaaauua uggcggcuau                                                   20


<210>  12
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12
gugacuagag cuaugga                                                      17


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13
gugauuuaau uauagagaga                                                   20


<210>  14
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14
aagtattacc agcc                                                         14


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15
gugaaugagg augagugaug                                                   20


