                               SEQUENCE LISTING

<110> SYNLOGIC OPERATING COMPANY, INC.
 
<120> COMBINATION THERAPIES OF MICROORGANISMS AND IMMUNE MODULATORS
      FOR USE IN TREATING CANCER

<130> 126046-05020

<140> Filed Herewith
<141> 2019-11-08

<150> US 62/848,294
<151> 2019-05-15

<150> US 62/757,452
<151> 2018-11-08

<160> 1446  

<170> PatentIn version 3.5

<210> 1
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Heavy chain humanized"

<400> 1
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210> 2
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Light chain humanized"

<400> 2
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210> 3
<211> 440
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Heavy chain human monoclonal"

<400> 3
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210> 4
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Light chain human monoclonal"

<400> 4
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 5
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ipilimumab, CTLA-4, Heavy chain"

<400> 5
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210> 6
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ipilimumab, CTLA-4, Heavy chain variable region"

<400> 6
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 7
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ipilimumab, CTLA-4, Light chain"

<400> 7
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210> 8
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ipilimumab, CTLA-4, Light chain variable region"

<400> 8
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 9
<211> 411
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Tremelimumab (CP675206), CTLA-4, Heavy chain"

<400> 9
Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser 
1               5                   10                  15      


Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            20                  25                  30          


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        35                  40                  45              


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr 
    50                  55                  60                  


Leu Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
65                  70                  75                  80  


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                85                  90                  95      


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
            100                 105                 110         


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
        115                 120                 125             


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
    130                 135                 140                 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
145                 150                 155                 160 


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
                165                 170                 175     


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
            180                 185                 190         


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210> 10
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Tremelimumab (CP675206), CTLA-4, Light chain"

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 11
<211> 442
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="PF-05082566, 4-1BB (CD137, TNFRSF9), Heavy chain"

<400> 11
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
            180                 185                 190         


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210> 12
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="PF-05082566, 4-1BB (CD137, TNFRSF9), Light chain"

<400> 12
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Lys Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Tyr Thr Gly Phe Gly Ser Leu 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210> 13
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Urelumab, 4-1BB (CD137, TNFRSF9), Heavy chain"

<400> 13
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210> 14
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Urelumab, 4-1BB (CD137, TNFRSF9), Light chain"

<400> 14
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Leu Thr Phe Cys Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210> 15
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-OX40 antibody (Providence Health and Services),"
      CD134 (OX40), Heavy chain"

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 16
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-OX40 antibody (Providence Health and Services),"
      CD134 (OX40), Light chain"

<400> 16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 17
<211> 440
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Nivolumab, PD-1, Heavy chain"

<400> 17
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210> 18
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Nivolumab, PD-1, Heavy chain variable region"

<400> 18
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210> 19
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Nivolumab, PD-1, Light chain"

<400> 19
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 20
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Nivolumab, PD-1, Light chain variable region"

<400> 20
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 21
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Pidilizumab, PD-1, Heavy chain"

<400> 21
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Ser Gly Glu Ser Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Thr Ser Leu Thr Ala Glu Asp Thr Gly Met Tyr Phe Cys 
                85                  90                  95      


Val Arg Val Gly Tyr Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 22

<400> 22
000


<210> 23
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Pidilizumab, PD-1, Light chain"

<400> 23
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Cys Leu Thr Ile Asn Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Phe Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 24

<400> 24
000


<210> 25
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Pembrolizumab (MK-3475/SCH900475, lambrolizumab) PD-1,
      Heavy chain"

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210> 26
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Pembrolizumab (MK-3475/SCH900475, lambrolizumab),
      PD-1, Light chain  Heavy chain variable region is 
      described in as described in WO2009114335"

<400> 26
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210> 27
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Durvalumab (MEDI4736), PD-L1, Heavy chain"

<400> 27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210> 28
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Durvalumab (MEDI4736), PD-L1, Light chain"

<400> 28
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210> 29
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Lirilumab, KIR, Heavy chain"

<400> 29
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Ile Pro Ile Phe Gly Ala Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Pro Ser Gly Ser Tyr Tyr Tyr Asp Tyr Asp Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210> 30
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Lirilumab, KIR, Light chain"

<400> 30
Glu Ile Val Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Met Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 31
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="BMS-986016, LAG3, Heavy chain"

<400> 31
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Ser Thr Asn Ser Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Phe Gly Tyr Ser Asp Tyr Glu Tyr Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210> 32
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="BMS986016, LAG3, Light chain"

<400> 32
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 33
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Avelumab (MSB0010718C), PD-L1, Heavy chain"

<400> 33
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 34
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Avelumab (MSB0010718C), PD-L1, Light chain"

<400> 34
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210> 35
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Atezolizumab (MPDL3280A, RG7446, RO5541267) PD-L1,
      Heavy chain"

<400> 35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210> 36
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Atezolizumab (MPDL3280A, RG7446, RO5541267) PD-L1,
      Heavy chain variable region"

<400> 36
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 37
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Atezolizumab (MPDL3280A, RG7446, RO5541267), PD-L1,
      Light chain"

<400> 37
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 38
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Atezolizumab (MPDL3280A, RG7446, RO5541267), PD-L1,
      Light chain variable region"

<400> 38
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 39
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Mogamulizumab, CCR4, Heavy chain"

<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Gly Arg His Ser Asp Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210> 40
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Mogamulizumab, CCR4, Light chain"

<400> 40
Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Asn Ile Val His Ile 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser Leu Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 41
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Varlilumab, CD27, Heavy chain"

<400> 41
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Asn Trp Gly Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Ser Ser 
    450         


<210> 42
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Varlilumab, CD27, Light chain"

<400> 42
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 43
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ulocuplumab, CXCR4, Heavy chain"

<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Arg Ser Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Gly Gln Pro Pro Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly 
    450     


<210> 44
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ulocuplumab, CXCR4, Light chain"

<400> 44
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Val Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 45
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Bavituximab, Phosphatidyl Serine, Heavy chain"

<400> 45
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asp Pro Tyr Tyr Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Gly Tyr Tyr Gly His Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 46
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Bavituxumab, Phosphatidyl Serine, Light chain"

<400> 46
Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly Ser Arg 
1               5                   10                  15      


Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp 
            20                  25                  30          


Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Val Ser Ser Pro Pro Thr Phe 
        35                  40                  45              


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Ser 
    50                  55                  60                  


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
65                  70                  75                  80  


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
                85                  90                  95      


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
            100                 105                 110         


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
        115                 120                 125             


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
    130                 135                 140                 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
145                 150                 155                 160 


Arg Gly Glu Cys 
                


<210> 47
<211> 7584
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Tet-regulated Tryptophan operon"

<400> 47
taagacccac tttcacattt aagttgtttt tctaatccgc atatgatcaa ttcaaggccg       60

aataagaagg ctggctctgc accttggtga tcaaataatt cgatagcttg tcgtaataat      120

ggcggcatac tatcagtagt aggtgtttcc ctttcttctt tagcgacttg atgctcttga      180

tcttccaata cgcaacctaa agtaaaatgc cccacagcgc tgagtgcata taatgcattc      240

tctagtgaaa aaccttgttg gcataaaaag gctaattgat tttcgagagt ttcatactgt      300

ttttctgtag gccgtgtacc taaatgtact tttgctccat cgcgatgact tagtaaagca      360

catctaaaac ttttagcgtt attacgtaaa aaatcttgcc agctttcccc ttctaaaggg      420

caaaagtgag tatggtgcct atctaacatc tcaatggcta aggcgtcgag caaagcccgc      480

ttatttttta catgccaata caatgtaggc tgctctacac ctagcttctg ggcgagttta      540

cgggttgtta aaccttcgat tccgacctca ttaagcagct ctaatgcgct gttaatcact      600

ttacttttat ctaatctaga catcattaat tcctaatttt tgttgacact ctatcattga      660

tagagttatt ttaccactcc ctatcagtga tagagaaaag tgaactctag aaataatttt      720

gtttaacttt aagaaggaga tatacatatg caaacacaaa aaccgactct cgaactgcta      780

acctgcgaag gcgcttatcg cgacaacccg actgcgcttt ttcaccagtt gtgtggggat      840

cgtccggcaa cgctgctgct ggaatccgca gatatcgaca gcaaagatga tttaaaaagc      900

ctgctgctgg tagacagtgc gctgcgcatt acagcattaa gtgacactgt cacaatccag      960

gcgctttccg gcaatggaga agccctgttg acactactgg ataacgcctt gcctgcgggt     1020

gtggaaaatg aacaatcacc aaactgccgc gtactgcgct tcccgcctgt cagtccactg     1080

ctggatgaag acgcccgctt atgctccctt tcggtttttg acgctttccg cttattacag     1140

aatctgttga atgtaccgaa ggaagaacga gaagcaatgt tcttcggcgg cctgttctct     1200

tatgaccttg tggcgggatt tgaaaattta ccgcaactgt cagcggaaaa tagctgccct     1260

gatttctgtt tttatctcgc tgaaacgctg atggtgattg accatcagaa aaaaagcact     1320

cgtattcagg ccagcctgtt tgctccgaat gaagaagaaa aacaacgtct cactgctcgc     1380

ctgaacgaac tacgtcagca actgaccgaa gccgcgccgc cgctgccggt ggtttccgtg     1440

ccgcatatgc gttgtgaatg taaccagagc gatgaagagt tcggtggtgt agtgcgtttg     1500

ttgcaaaaag cgattcgcgc cggagaaatt ttccaggtgg tgccatctcg ccgtttctct     1560

ctgccctgcc cgtcaccgct ggcagcctat tacgtgctga aaaagagtaa tcccagcccg     1620

tacatgtttt ttatgcagga taatgatttc accctgtttg gcgcgtcgcc ggaaagttcg     1680

ctcaagtatg acgccaccag ccgccagatt gagatttacc cgattgccgg aacacgtcca     1740

cgcggtcgtc gtgccgatgg ttcgctggac agagacctcg acagccgcat cgaactggag     1800

atgcgtaccg atcataaaga gctttctgaa catctgatgc tggtggatct cgcccgtaat     1860

gacctggcac gcatttgcac acccggcagc cgctacgtcg ccgatctcac caaagttgac     1920

cgttactctt acgtgatgca cctagtctcc cgcgttgttg gtgagctgcg ccacgatctc     1980

gacgccctgc acgcttaccg cgcctgtatg aatatgggga cgttaagcgg tgcaccgaaa     2040

gtacgcgcta tgcagttaat tgccgaagca gaaggtcgtc gacgcggcag ctacggcggc     2100

gcggtaggtt attttaccgc gcatggcgat ctcgacacct gcattgtgat ccgctcggcg     2160

ctggtggaaa acggtatcgc caccgtgcaa gccggtgctg gcgtagtcct tgattctgtt     2220

ccgcagtcgg aagccgacga aactcgtaat aaagcccgcg ctgtactgcg cgctattgcc     2280

accgcgcatc atgcacagga gacgttctaa tggctgacat tctgctgctc gataatatcg     2340

actcttttac gtacaacctg gcagatcagt tgcgcagcaa tggtcataac gtggtgattt     2400

accgcaacca tattccggcg cagaccttaa ttgaacgcct ggcgacgatg agcaatccgg     2460

tgctgatgct ttctcctggc cccggtgtgc cgagcgaagc cggttgtatg ccggaactcc     2520

tcacccgctt gcgtggcaag ctgccaatta ttggcatttg cctcggacat caggcgattg     2580

tcgaagctta cgggggctat gtcggtcagg cgggcgaaat tcttcacggt aaagcgtcga     2640

gcattgaaca tgacggtcag gcgatgtttg ccggattaac aaacccgctg ccagtggcgc     2700

gttatcactc gctggttggc agtaacattc cggccggttt aaccatcaac gcccatttta     2760

atggcatggt gatggcggtg cgtcacgatg cagatcgcgt ttgtggattc cagttccatc     2820

cggaatccat tcttactacc cagggcgctc gcctgctgga acaaacgctg gcctgggcgc     2880

agcagaaact agagccaacc aacacgctgc aaccgattct ggaaaaactg tatcaggcac     2940

agacgcttag ccaacaagaa agccaccagc tgttttcagc ggtggtacgt ggcgagctga     3000

agccggaaca actggcggcg gcgctggtga gcatgaaaat tcgcggtgaa cacccgaacg     3060

agatcgccgg ggcagcaacc gcgctactgg aaaacgccgc gccattcccg cgcccggatt     3120

atctgtttgc cgatatcgtc ggtactggcg gtgacggcag caacagcatc aatatttcta     3180

ccgccagtgc gtttgtcgcc gcggcctgcg ggctgaaagt ggcgaaacac ggcaaccgta     3240

gcgtctccag taaatccggc tcgtcggatc tgctggcggc gttcggtatt aatcttgata     3300

tgaacgccga taaatcgcgc caggcgctgg atgagttagg cgtctgtttc ctctttgcgc     3360

cgaagtatca caccggattc cgccatgcga tgccggttcg ccagcaactg aaaacccgca     3420

ctctgttcaa cgtgctggga ccattgatta acccggcgca tccgccgctg gcgctaattg     3480

gtgtttatag tccggaactg gtgctgccga ttgccgaaac cttgcgcgtg ctggggtatc     3540

aacgcgcggc agtggtgcac agcggcggga tggatgaagt ttcattacac gcgccgacaa     3600

tcgttgccga actacatgac ggcgaaatta agagctatca attgaccgct gaagattttg     3660

gcctgacacc ctaccaccag gagcaattgg caggcggaac accggaagaa aaccgtgaca     3720

ttttaacacg cttgttacaa ggtaaaggcg acgccgccca tgaagcagcc gtcgcggcga     3780

atgtcgccat gttaatgcgc ctgcatggcc atgaagatct gcaagccaat gcgcaaaccg     3840

ttcttgaggt actgcgcagt ggttccgctt acgacagagt caccgcactg gcggcacgag     3900

ggtaaatgat gcaaaccgtt ttagcgaaaa tcgtcgcaga caaggcgatt tgggtagaaa     3960

cccgcaaaga gcagcaaccg ctggccagtt ttcagaatga ggttcagccg agcacgcgac     4020

atttttatga tgcacttcag ggcgcacgca cggcgtttat tctggagtgt aaaaaagcgt     4080

cgccgtcaaa aggcgtgatc cgtgatgatt tcgatccggc acgcattgcc gccatttata     4140

aacattacgc ttcggcaatt tcagtgctga ctgatgagaa atattttcag gggagctttg     4200

atttcctccc catcgtcagc caaatcgccc cgcagccgat tttatgtaaa gacttcatta     4260

tcgatcctta ccagatctat ctggcgcgct attaccaggc cgatgcctgc ttattaatgc     4320

tttcagtact ggatgacgaa caatatcgcc agcttgcagc cgtcgcccac agtctggaga     4380

tgggtgtgct gaccgaagtc agtaatgaag aggaactgga gcgcgccatt gcattggggg     4440

caaaggtcgt tggcatcaac aaccgcgatc tgcgcgattt gtcgattgat ctcaaccgta     4500

cccgcgagct tgcgccgaaa ctggggcaca acgtgacggt aatcagcgaa tccggcatca     4560

atacttacgc tcaggtgcgc gagttaagcc acttcgctaa cggctttctg attggttcgg     4620

cgttgatggc ccatgacgat ttgaacgccg ccgtgcgtcg ggtgttgctg ggtgagaata     4680

aagtatgtgg cctgacacgt gggcaagatg ctaaagcagc ttatgacgcg ggcgcgattt     4740

acggtgggtt gatttttgtt gcgacatcac cgcgttgcgt caacgttgaa caggcgcagg     4800

aagtgatggc tgcagcaccg ttgcagtatg ttggcgtgtt ccgcaatcac gatattgccg     4860

atgtggcgga caaagctaag gtgttatcgc tggcggcagt gcaactgcat ggtaatgaag     4920

atcagctgta tatcgacaat ctgcgtgagg ctctgccagc acacgtcgcc atctggaagg     4980

ctttaagtgt cggtgaaact cttcccgcgc gcgattttca gcacatcgat aaatatgtat     5040

tcgacaacgg tcagggcggg agcggacaac gtttcgactg gtcactatta aatggtcaat     5100

cgcttggcaa cgttctgctg gcggggggct taggcgcaga taactgcgtg gaagcggcac     5160

aaaccggctg cgccgggctt gattttaatt ctgctgtaga gtcgcaaccg ggtatcaaag     5220

acgcacgtct tttggcctcg gttttccaga cgctgcgcgc atattaagga aaggaacaat     5280

gacaacatta cttaacccct attttggtga gtttggcggc atgtacgtgc cacaaatcct     5340

gatgcctgct ctgcgccagc tggaagaagc ttttgtcagc gcgcaaaaag atcctgaatt     5400

tcaggctcag ttcaacgacc tgctgaaaaa ctatgccggg cgtccaaccg cgctgaccaa     5460

atgccagaac attacagccg ggacgaacac cacgctgtat ctgaagcgcg aagatttgct     5520

gcacggcggc gcgcataaaa ctaaccaggt gctcggtcag gctttactgg cgaagcggat     5580

gggtaaaact gaaattattg ccgaaaccgg tgccggtcag catggcgtgg cgtcggccct     5640

tgccagcgcc ctgctcggcc tgaaatgccg aatttatatg ggtgccaaag acgttgaacg     5700

ccagtcgccc aacgttttcc ggatgcgctt aatgggtgcg gaagtgatcc cggtacatag     5760

cggttccgcg accctgaaag atgcctgtaa tgaggcgcta cgcgactggt ccggcagtta     5820

tgaaaccgcg cactatatgc tgggtaccgc agctggcccg catccttacc cgaccattgt     5880

gcgtgagttt cagcggatga ttggcgaaga aacgaaagcg cagattctgg aaagagaagg     5940

tcgcctgccg gatgccgtta tcgcctgtgt tggcggtggt tcgaatgcca tcggtatgtt     6000

tgcagatttc atcaacgaaa ccgacgtcgg cctgattggt gtggagcctg gcggccacgg     6060

tatcgaaact ggcgagcacg gcgcaccgtt aaaacatggt cgcgtgggca tctatttcgg     6120

tatgaaagcg ccgatgatgc aaaccgaaga cgggcaaatt gaagagtctt actccatttc     6180

tgccgggctg gatttcccgt ccgtcggccc gcaacatgcg tatctcaaca gcactggacg     6240

cgctgattac gtgtctatta ccgacgatga agccctggaa gcctttaaaa cgctttgcct     6300

gcatgaaggg atcatcccgg cgctggaatc ctcccacgcc ctggcccatg cgctgaaaat     6360

gatgcgcgaa aatccggaaa aagagcagct actggtggtt aacctttccg gtcgcggcga     6420

taaagacatc ttcaccgttc acgatatttt gaaagcacga ggggaaatct gatggaacgc     6480

tacgaatctc tgtttgccca gttgaaggag cgcaaagaag gcgcattcgt tcctttcgtc     6540

accctcggtg atccgggcat tgagcagtcg ttgaaaatta tcgatacgct aattgaagcc     6600

ggtgctgacg cgctggagtt aggcatcccc ttctccgacc cactggcgga tggcccgacg     6660

attcaaaacg ccacactgcg tgcttttgcg gcgggagtaa ccccggcgca gtgctttgag     6720

atgctggcac tcattcgcca gaagcacccg accattccca tcggcctttt gatgtatgcc     6780

aacctggtgt ttaacaaagg cattgatgag ttttatgccg agtgcgagaa agtcggcgtc     6840

gattcggtgc tggttgccga tgtgcccgtg gaagagtccg cgcccttccg ccaggccgcg     6900

ttgcgtcata atgtcgcacc tatctttatt tgcccgccga atgccgacga tgatttgctg     6960

cgccagatag cctcttacgg tcgtggttac acctatttgc tgtcgcgagc gggcgtgacc     7020

ggcgcagaaa accgcgccgc gttacccctc aatcatctgg ttgcgaagct gaaagagtac     7080

aacgctgcgc ctccattgca gggatttggt atttccgccc cggatcaggt aaaagccgcg     7140

attgatgcag gagctgcggg cgcgatttct ggttcggcca tcgttaaaat catcgagcaa     7200

catattaatg agccagagaa aatgctggcg gcactgaaag cttttgtaca accgatgaaa     7260

gcggcgacgc gcagttaata cgcatggcat ggatgaccga tggtagtgtg gggtctcccc     7320

atgcgagagt agggaactgc caggcatcaa ataaaacgaa aggctcagtc gaaagactgg     7380

gcctttcgtt ttatctgttg tttgtcggtg aacgctctcc tgagtaggac aaatccgccg     7440

ggagcggatt tgaacgttgc gaagcaacgg cccggagggt ggcgggcagg acgcccgcca     7500

taaactgcca ggcatcaaat taagcagaag gccatcctga cggatggcct ttttgcgtgg     7560

ccagtgccaa gcttgcatgc gtgc                                            7584


<210> 48
<211> 623
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Tet repressor"

<400> 48
taagacccac tttcacattt aagttgtttt tctaatccgc atatgatcaa ttcaaggccg       60

aataagaagg ctggctctgc accttggtga tcaaataatt cgatagcttg tcgtaataat      120

ggcggcatac tatcagtagt aggtgtttcc ctttcttctt tagcgacttg atgctcttga      180

tcttccaata cgcaacctaa agtaaaatgc cccacagcgc tgagtgcata taatgcattc      240

tctagtgaaa aaccttgttg gcataaaaag gctaattgat tttcgagagt ttcatactgt      300

ttttctgtag gccgtgtacc taaatgtact tttgctccat cgcgatgact tagtaaagca      360

catctaaaac ttttagcgtt attacgtaaa aaatcttgcc agctttcccc ttctaaaggg      420

caaaagtgag tatggtgcct atctaacatc tcaatggcta aggcgtcgag caaagcccgc      480

ttatttttta catgccaata caatgtaggc tgctctacac ctagcttctg ggcgagttta      540

cgggttgtta aaccttcgat tccgacctca ttaagcagct ctaatgcgct gttaatcact      600

ttacttttat ctaatctaga cat                                              623


<210> 49
<211> 124
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="tetR/tetA promoters and RBS and leader region"

<400> 49
cattaattcc taatttttgt tgacactcta tcattgatag agttatttta ccactcccta       60

tcagtgatag agaaaagtga actctagaaa taattttgtt taactttaag aaggagatat      120

acat                                                                   124


<210> 50
<211> 1562
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="trpE"

<400> 50
atgcaaacac aaaaaccgac tctcgaactg ctaacctgcg aaggcgctta tcgcgacaac       60

ccgactgcgc tttttcacca gttgtgtggg gatcgtccgg caacgctgct gctggaatcc      120

gcagatatcg acagcaaaga tgatttaaaa agcctgctgc tggtagacag tgcgctgcgc      180

attacagcat taagtgacac tgtcacaatc caggcgcttt ccggcaatgg agaagccctg      240

ttgacactac tggataacgc cttgcctgcg ggtgtggaaa atgaacaatc accaaactgc      300

cgcgtactgc gcttcccgcc tgtcagtcca ctgctggatg aagacgcccg cttatgctcc      360

ctttcggttt ttgacgcttt ccgcttatta cagaatctgt tgaatgtacc gaaggaagaa      420

cgagaagcaa tgttcttcgg cggcctgttc tcttatgacc ttgtggcggg atttgaaaat      480

ttaccgcaac tgtcagcgga aaatagctgc cctgatttct gtttttatct cgctgaaacg      540

ctgatggtga ttgaccatca gaaaaaaagc actcgtattc aggccagcct gtttgctccg      600

aatgaagaag aaaaacaacg tctcactgct cgcctgaacg aactacgtca gcaactgacc      660

gaagccgcgc cgccgctgcc ggtggtttcc gtgccgcata tgcgttgtga atgtaaccag      720

agcgatgaag agttcggtgg tgtagtgcgt ttgttgcaaa aagcgattcg cgccggagaa      780

attttccagg tggtgccatc tcgccgtttc tctctgccct gcccgtcacc gctggcagcc      840

tattacgtgc tgaaaaagag taatcccagc ccgtacatgt tttttatgca ggataatgat      900

ttcaccctgt ttggcgcgtc gccggaaagt tcgctcaagt atgacgccac cagccgccag      960

attgagattt acccgattgc cggaacacgt ccacgcggtc gtcgtgccga tggttcgctg     1020

gacagagacc tcgacagccg catcgaactg gagatgcgta ccgatcataa agagctttct     1080

gaacatctga tgctggtgga tctcgcccgt aatgacctgg cacgcatttg cacacccggc     1140

agccgctacg tcgccgatct caccaaagtt gaccgttact cttacgtgat gcacctagtc     1200

tcccgcgttg ttggtgagct gcgccacgat ctcgacgccc tgcacgctta ccgcgcctgt     1260

atgaatatgg ggacgttaag cggtgcaccg aaagtacgcg ctatgcagtt aattgccgaa     1320

gcagaaggtc gtcgacgcgg cagctacggc ggcgcggtag gttattttac cgcgcatggc     1380

gatctcgaca cctgcattgt gatccgctcg gcgctggtgg aaaacggtat cgccaccgtg     1440

caagccggtg ctggcgtagt ccttgattct gttccgcagt cggaagccga cgaaactcgt     1500

aataaagccc gcgctgtact gcgcgctatt gccaccgcgc atcatgcaca ggagacgttc     1560

ta                                                                    1562


<210> 51
<211> 1596
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="trpD"

<400> 51
atggctgaca ttctgctgct cgataatatc gactctttta cgtacaacct ggcagatcag       60

ttgcgcagca atggtcataa cgtggtgatt taccgcaacc atattccggc gcagacctta      120

attgaacgcc tggcgacgat gagcaatccg gtgctgatgc tttctcctgg ccccggtgtg      180

ccgagcgaag ccggttgtat gccggaactc ctcacccgct tgcgtggcaa gctgccaatt      240

attggcattt gcctcggaca tcaggcgatt gtcgaagctt acgggggcta tgtcggtcag      300

gcgggcgaaa ttcttcacgg taaagcgtcg agcattgaac atgacggtca ggcgatgttt      360

gccggattaa caaacccgct gccagtggcg cgttatcact cgctggttgg cagtaacatt      420

ccggccggtt taaccatcaa cgcccatttt aatggcatgg tgatggcggt gcgtcacgat      480

gcagatcgcg tttgtggatt ccagttccat ccggaatcca ttcttactac ccagggcgct      540

cgcctgctgg aacaaacgct ggcctgggcg cagcagaaac tagagccaac caacacgctg      600

caaccgattc tggaaaaact gtatcaggca cagacgctta gccaacaaga aagccaccag      660

ctgttttcag cggtggtacg tggcgagctg aagccggaac aactggcggc ggcgctggtg      720

agcatgaaaa ttcgcggtga acacccgaac gagatcgccg gggcagcaac cgcgctactg      780

gaaaacgccg cgccattccc gcgcccggat tatctgtttg ccgatatcgt cggtactggc      840

ggtgacggca gcaacagcat caatatttct accgccagtg cgtttgtcgc cgcggcctgc      900

gggctgaaag tggcgaaaca cggcaaccgt agcgtctcca gtaaatccgg ctcgtcggat      960

ctgctggcgg cgttcggtat taatcttgat atgaacgccg ataaatcgcg ccaggcgctg     1020

gatgagttag gcgtctgttt cctctttgcg ccgaagtatc acaccggatt ccgccatgcg     1080

atgccggttc gccagcaact gaaaacccgc actctgttca acgtgctggg accattgatt     1140

aacccggcgc atccgccgct ggcgctaatt ggtgtttata gtccggaact ggtgctgccg     1200

attgccgaaa ccttgcgcgt gctggggtat caacgcgcgg cagtggtgca cagcggcggg     1260

atggatgaag tttcattaca cgcgccgaca atcgttgccg aactacatga cggcgaaatt     1320

aagagctatc aattgaccgc tgaagatttt ggcctgacac cctaccacca ggagcaattg     1380

gcaggcggaa caccggaaga aaaccgtgac attttaacac gcttgttaca aggtaaaggc     1440

gacgccgccc atgaagcagc cgtcgcggcg aatgtcgcca tgttaatgcg cctgcatggc     1500

catgaagatc tgcaagccaa tgcgcaaacc gttcttgagg tactgcgcag tggttccgct     1560

tacgacagag tcaccgcact ggcggcacga gggtaa                               1596


<210> 52
<211> 1359
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="trpC"

<400> 52
atgcaaaccg ttttagcgaa aatcgtcgca gacaaggcga tttgggtaga aacccgcaaa       60

gagcagcaac cgctggccag ttttcagaat gaggttcagc cgagcacgcg acatttttat      120

gatgcacttc agggcgcacg cacggcgttt attctggagt gtaaaaaagc gtcgccgtca      180

aaaggcgtga tccgtgatga tttcgatccg gcacgcattg ccgccattta taaacattac      240

gcttcggcaa tttcagtgct gactgatgag aaatattttc aggggagctt tgatttcctc      300

cccatcgtca gccaaatcgc cccgcagccg attttatgta aagacttcat tatcgatcct      360

taccagatct atctggcgcg ctattaccag gccgatgcct gcttattaat gctttcagta      420

ctggatgacg aacaatatcg ccagcttgca gccgtcgccc acagtctgga gatgggtgtg      480

ctgaccgaag tcagtaatga agaggaactg gagcgcgcca ttgcattggg ggcaaaggtc      540

gttggcatca acaaccgcga tctgcgcgat ttgtcgattg atctcaaccg tacccgcgag      600

cttgcgccga aactggggca caacgtgacg gtaatcagcg aatccggcat caatacttac      660

gctcaggtgc gcgagttaag ccacttcgct aacggctttc tgattggttc ggcgttgatg      720

gcccatgacg atttgaacgc cgccgtgcgt cgggtgttgc tgggtgagaa taaagtatgt      780

ggcctgacac gtgggcaaga tgctaaagca gcttatgacg cgggcgcgat ttacggtggg      840

ttgatttttg ttgcgacatc accgcgttgc gtcaacgttg aacaggcgca ggaagtgatg      900

gctgcagcac cgttgcagta tgttggcgtg ttccgcaatc acgatattgc cgatgtggcg      960

gacaaagcta aggtgttatc gctggcggca gtgcaactgc atggtaatga agatcagctg     1020

tatatcgaca atctgcgtga ggctctgcca gcacacgtcg ccatctggaa ggctttaagt     1080

gtcggtgaaa ctcttcccgc gcgcgatttt cagcacatcg ataaatatgt attcgacaac     1140

ggtcagggcg ggagcggaca acgtttcgac tggtcactat taaatggtca atcgcttggc     1200

aacgttctgc tggcgggggg cttaggcgca gataactgcg tggaagcggc acaaaccggc     1260

tgcgccgggc ttgattttaa ttctgctgta gagtcgcaac cgggtatcaa agacgcacgt     1320

cttttggcct cggttttcca gacgctgcgc gcatattaa                            1359


<210> 53
<211> 1194
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="trpB"

<400> 53
atgacaacat tacttaaccc ctattttggt gagtttggcg gcatgtacgt gccacaaatc       60

ctgatgcctg ctctgcgcca gctggaagaa gcttttgtca gcgcgcaaaa agatcctgaa      120

tttcaggctc agttcaacga cctgctgaaa aactatgccg ggcgtccaac cgcgctgacc      180

aaatgccaga acattacagc cgggacgaac accacgctgt atctgaagcg cgaagatttg      240

ctgcacggcg gcgcgcataa aactaaccag gtgctcggtc aggctttact ggcgaagcgg      300

atgggtaaaa ctgaaattat tgccgaaacc ggtgccggtc agcatggcgt ggcgtcggcc      360

cttgccagcg ccctgctcgg cctgaaatgc cgaatttata tgggtgccaa agacgttgaa      420

cgccagtcgc ccaacgtttt ccggatgcgc ttaatgggtg cggaagtgat cccggtacat      480

agcggttccg cgaccctgaa agatgcctgt aatgaggcgc tacgcgactg gtccggcagt      540

tatgaaaccg cgcactatat gctgggtacc gcagctggcc cgcatcctta cccgaccatt      600

gtgcgtgagt ttcagcggat gattggcgaa gaaacgaaag cgcagattct ggaaagagaa      660

ggtcgcctgc cggatgccgt tatcgcctgt gttggcggtg gttcgaatgc catcggtatg      720

tttgcagatt tcatcaacga aaccgacgtc ggcctgattg gtgtggagcc tggcggccac      780

ggtatcgaaa ctggcgagca cggcgcaccg ttaaaacatg gtcgcgtggg catctatttc      840

ggtatgaaag cgccgatgat gcaaaccgaa gacgggcaaa ttgaagagtc ttactccatt      900

tctgccgggc tggatttccc gtccgtcggc ccgcaacatg cgtatctcaa cagcactgga      960

cgcgctgatt acgtgtctat taccgacgat gaagccctgg aagcctttaa aacgctttgc     1020

ctgcatgaag ggatcatccc ggcgctggaa tcctcccacg ccctggccca tgcgctgaaa     1080

atgatgcgcg aaaatccgga aaaagagcag ctactggtgg ttaacctttc cggtcgcggc     1140

gataaagaca tcttcaccgt tcacgatatt ttgaaagcac gaggggaaat ctga           1194


<210> 54
<211> 807
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="trpA"

<400> 54
atggaacgct acgaatctct gtttgcccag ttgaaggagc gcaaagaagg cgcattcgtt       60

cctttcgtca ccctcggtga tccgggcatt gagcagtcgt tgaaaattat cgatacgcta      120

attgaagccg gtgctgacgc gctggagtta ggcatcccct tctccgaccc actggcggat      180

ggcccgacga ttcaaaacgc cacactgcgt gcttttgcgg cgggagtaac cccggcgcag      240

tgctttgaga tgctggcact cattcgccag aagcacccga ccattcccat cggccttttg      300

atgtatgcca acctggtgtt taacaaaggc attgatgagt tttatgccga gtgcgagaaa      360

gtcggcgtcg attcggtgct ggttgccgat gtgcccgtgg aagagtccgc gcccttccgc      420

caggccgcgt tgcgtcataa tgtcgcacct atctttattt gcccgccgaa tgccgacgat      480

gatttgctgc gccagatagc ctcttacggt cgtggttaca cctatttgct gtcgcgagcg      540

ggcgtgaccg gcgcagaaaa ccgcgccgcg ttacccctca atcatctggt tgcgaagctg      600

aaagagtaca acgctgcgcc tccattgcag ggatttggta tttccgcccc ggatcaggta      660

aaagccgcga ttgatgcagg agctgcgggc gcgatttctg gttcggccat cgttaaaatc      720

atcgagcaac atattaatga gccagagaaa atgctggcgg cactgaaagc ttttgtacaa      780

ccgatgaaag cggcgacgcg cagttaa                                          807


<210> 55
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="TrpE"

<400> 55
Met Gln Thr Gln Lys Pro Thr Leu Glu Leu Leu Thr Cys Glu Gly Ala 
1               5                   10                  15      


Tyr Arg Asp Asn Pro Thr Ala Leu Phe His Gln Leu Cys Gly Asp Arg 
            20                  25                  30          


Pro Ala Thr Leu Leu Leu Glu Ser Ala Asp Ile Asp Ser Lys Asp Asp 
        35                  40                  45              


Leu Lys Ser Leu Leu Leu Val Asp Ser Ala Leu Arg Ile Thr Ala Leu 
    50                  55                  60                  


Ser Asp Thr Val Thr Ile Gln Ala Leu Ser Gly Asn Gly Glu Ala Leu 
65                  70                  75                  80  


Leu Thr Leu Leu Asp Asn Ala Leu Pro Ala Gly Val Glu Asn Glu Gln 
                85                  90                  95      


Ser Pro Asn Cys Arg Val Leu Arg Phe Pro Pro Val Ser Pro Leu Leu 
            100                 105                 110         


Asp Glu Asp Ala Arg Leu Cys Ser Leu Ser Val Phe Asp Ala Phe Arg 
        115                 120                 125             


Leu Leu Gln Asn Leu Leu Asn Val Pro Lys Glu Glu Arg Glu Ala Met 
    130                 135                 140                 


Phe Phe Gly Gly Leu Phe Ser Tyr Asp Leu Val Ala Gly Phe Glu Asn 
145                 150                 155                 160 


Leu Pro Gln Leu Ser Ala Glu Asn Ser Cys Pro Asp Phe Cys Phe Tyr 
                165                 170                 175     


Leu Ala Glu Thr Leu Met Val Ile Asp His Gln Lys Lys Ser Thr Arg 
            180                 185                 190         


Ile Gln Ala Ser Leu Phe Ala Pro Asn Glu Glu Glu Lys Gln Arg Leu 
        195                 200                 205             


Thr Ala Arg Leu Asn Glu Leu Arg Gln Gln Leu Thr Glu Ala Ala Pro 
    210                 215                 220                 


Pro Leu Pro Val Val Ser Val Pro His Met Arg Cys Glu Cys Asn Gln 
225                 230                 235                 240 


Ser Asp Glu Glu Phe Gly Gly Val Val Arg Leu Leu Gln Lys Ala Ile 
                245                 250                 255     


Arg Ala Gly Glu Ile Phe Gln Val Val Pro Ser Arg Arg Phe Ser Leu 
            260                 265                 270         


Pro Cys Pro Ser Pro Leu Ala Ala Tyr Tyr Val Leu Lys Lys Ser Asn 
        275                 280                 285             


Pro Ser Pro Tyr Met Phe Phe Met Gln Asp Asn Asp Phe Thr Leu Phe 
    290                 295                 300                 


Gly Ala Ser Pro Glu Ser Ser Leu Lys Tyr Asp Ala Thr Ser Arg Gln 
305                 310                 315                 320 


Ile Glu Ile Tyr Pro Ile Ala Gly Thr Arg Pro Arg Gly Arg Arg Ala 
                325                 330                 335     


Asp Gly Ser Leu Asp Arg Asp Leu Asp Ser Arg Ile Glu Leu Glu Met 
            340                 345                 350         


Arg Thr Asp His Lys Glu Leu Ser Glu His Leu Met Leu Val Asp Leu 
        355                 360                 365             


Ala Arg Asn Asp Leu Ala Arg Ile Cys Thr Pro Gly Ser Arg Tyr Val 
    370                 375                 380                 


Ala Asp Leu Thr Lys Val Asp Arg Tyr Ser Tyr Val Met His Leu Val 
385                 390                 395                 400 


Ser Arg Val Val Gly Glu Leu Arg His Asp Leu Asp Ala Leu His Ala 
                405                 410                 415     


Tyr Arg Ala Cys Met Asn Met Gly Thr Leu Ser Gly Ala Pro Lys Val 
            420                 425                 430         


Arg Ala Met Gln Leu Ile Ala Glu Ala Glu Gly Arg Arg Arg Gly Ser 
        435                 440                 445             


Tyr Gly Gly Ala Val Gly Tyr Phe Thr Ala His Gly Asp Leu Asp Thr 
    450                 455                 460                 


Cys Ile Val Ile Arg Ser Ala Leu Val Glu Asn Gly Ile Ala Thr Val 
465                 470                 475                 480 


Gln Ala Gly Ala Gly Val Val Leu Asp Ser Val Pro Gln Ser Glu Ala 
                485                 490                 495     


Asp Glu Thr Arg Asn Lys Ala Arg Ala Val Leu Arg Ala Ile Ala Thr 
            500                 505                 510         


Ala His His Ala Gln Glu Thr Phe 
        515                 520 


<210> 56
<211> 531
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="TrpD"

<400> 56
Met Ala Asp Ile Leu Leu Leu Asp Asn Ile Asp Ser Phe Thr Tyr Asn 
1               5                   10                  15      


Leu Ala Asp Gln Leu Arg Ser Asn Gly His Asn Val Val Ile Tyr Arg 
            20                  25                  30          


Asn His Ile Pro Ala Gln Thr Leu Ile Glu Arg Leu Ala Thr Met Ser 
        35                  40                  45              


Asn Pro Val Leu Met Leu Ser Pro Gly Pro Gly Val Pro Ser Glu Ala 
    50                  55                  60                  


Gly Cys Met Pro Glu Leu Leu Thr Arg Leu Arg Gly Lys Leu Pro Ile 
65                  70                  75                  80  


Ile Gly Ile Cys Leu Gly His Gln Ala Ile Val Glu Ala Tyr Gly Gly 
                85                  90                  95      


Tyr Val Gly Gln Ala Gly Glu Ile Leu His Gly Lys Ala Ser Ser Ile 
            100                 105                 110         


Glu His Asp Gly Gln Ala Met Phe Ala Gly Leu Thr Asn Pro Leu Pro 
        115                 120                 125             


Val Ala Arg Tyr His Ser Leu Val Gly Ser Asn Ile Pro Ala Gly Leu 
    130                 135                 140                 


Thr Ile Asn Ala His Phe Asn Gly Met Val Met Ala Val Arg His Asp 
145                 150                 155                 160 


Ala Asp Arg Val Cys Gly Phe Gln Phe His Pro Glu Ser Ile Leu Thr 
                165                 170                 175     


Thr Gln Gly Ala Arg Leu Leu Glu Gln Thr Leu Ala Trp Ala Gln Gln 
            180                 185                 190         


Lys Leu Glu Pro Thr Asn Thr Leu Gln Pro Ile Leu Glu Lys Leu Tyr 
        195                 200                 205             


Gln Ala Gln Thr Leu Ser Gln Gln Glu Ser His Gln Leu Phe Ser Ala 
    210                 215                 220                 


Val Val Arg Gly Glu Leu Lys Pro Glu Gln Leu Ala Ala Ala Leu Val 
225                 230                 235                 240 


Ser Met Lys Ile Arg Gly Glu His Pro Asn Glu Ile Ala Gly Ala Ala 
                245                 250                 255     


Thr Ala Leu Leu Glu Asn Ala Ala Pro Phe Pro Arg Pro Asp Tyr Leu 
            260                 265                 270         


Phe Ala Asp Ile Val Gly Thr Gly Gly Asp Gly Ser Asn Ser Ile Asn 
        275                 280                 285             


Ile Ser Thr Ala Ser Ala Phe Val Ala Ala Ala Cys Gly Leu Lys Val 
    290                 295                 300                 


Ala Lys His Gly Asn Arg Ser Val Ser Ser Lys Ser Gly Ser Ser Asp 
305                 310                 315                 320 


Leu Leu Ala Ala Phe Gly Ile Asn Leu Asp Met Asn Ala Asp Lys Ser 
                325                 330                 335     


Arg Gln Ala Leu Asp Glu Leu Gly Val Cys Phe Leu Phe Ala Pro Lys 
            340                 345                 350         


Tyr His Thr Gly Phe Arg His Ala Met Pro Val Arg Gln Gln Leu Lys 
        355                 360                 365             


Thr Arg Thr Leu Phe Asn Val Leu Gly Pro Leu Ile Asn Pro Ala His 
    370                 375                 380                 


Pro Pro Leu Ala Leu Ile Gly Val Tyr Ser Pro Glu Leu Val Leu Pro 
385                 390                 395                 400 


Ile Ala Glu Thr Leu Arg Val Leu Gly Tyr Gln Arg Ala Ala Val Val 
                405                 410                 415     


His Ser Gly Gly Met Asp Glu Val Ser Leu His Ala Pro Thr Ile Val 
            420                 425                 430         


Ala Glu Leu His Asp Gly Glu Ile Lys Ser Tyr Gln Leu Thr Ala Glu 
        435                 440                 445             


Asp Phe Gly Leu Thr Pro Tyr His Gln Glu Gln Leu Ala Gly Gly Thr 
    450                 455                 460                 


Pro Glu Glu Asn Arg Asp Ile Leu Thr Arg Leu Leu Gln Gly Lys Gly 
465                 470                 475                 480 


Asp Ala Ala His Glu Ala Ala Val Ala Ala Asn Val Ala Met Leu Met 
                485                 490                 495     


Arg Leu His Gly His Glu Asp Leu Gln Ala Asn Ala Gln Thr Val Leu 
            500                 505                 510         


Glu Val Leu Arg Ser Gly Ser Ala Tyr Asp Arg Val Thr Ala Leu Ala 
        515                 520                 525             


Ala Arg Gly 
    530     


<210> 57
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="TrpC"

<400> 57
Met Gln Thr Val Leu Ala Lys Ile Val Ala Asp Lys Ala Ile Trp Val 
1               5                   10                  15      


Glu Thr Arg Lys Glu Gln Gln Pro Leu Ala Ser Phe Gln Asn Glu Val 
            20                  25                  30          


Gln Pro Ser Thr Arg His Phe Tyr Asp Ala Leu Gln Gly Ala Arg Thr 
        35                  40                  45              


Ala Phe Ile Leu Glu Cys Lys Lys Ala Ser Pro Ser Lys Gly Val Ile 
    50                  55                  60                  


Arg Asp Asp Phe Asp Pro Ala Arg Ile Ala Ala Ile Tyr Lys His Tyr 
65                  70                  75                  80  


Ala Ser Ala Ile Ser Val Leu Thr Asp Glu Lys Tyr Phe Gln Gly Ser 
                85                  90                  95      


Phe Asp Phe Leu Pro Ile Val Ser Gln Ile Ala Pro Gln Pro Ile Leu 
            100                 105                 110         


Cys Lys Asp Phe Ile Ile Asp Pro Tyr Gln Ile Tyr Leu Ala Arg Tyr 
        115                 120                 125             


Tyr Gln Ala Asp Ala Cys Leu Leu Met Leu Ser Val Leu Asp Asp Glu 
    130                 135                 140                 


Gln Tyr Arg Gln Leu Ala Ala Val Ala His Ser Leu Glu Met Gly Val 
145                 150                 155                 160 


Leu Thr Glu Val Ser Asn Glu Glu Glu Leu Glu Arg Ala Ile Ala Leu 
                165                 170                 175     


Gly Ala Lys Val Val Gly Ile Asn Asn Arg Asp Leu Arg Asp Leu Ser 
            180                 185                 190         


Ile Asp Leu Asn Arg Thr Arg Glu Leu Ala Pro Lys Leu Gly His Asn 
        195                 200                 205             


Val Thr Val Ile Ser Glu Ser Gly Ile Asn Thr Tyr Ala Gln Val Arg 
    210                 215                 220                 


Glu Leu Ser His Phe Ala Asn Gly Phe Leu Ile Gly Ser Ala Leu Met 
225                 230                 235                 240 


Ala His Asp Asp Leu Asn Ala Ala Val Arg Arg Val Leu Leu Gly Glu 
                245                 250                 255     


Asn Lys Val Cys Gly Leu Thr Arg Gly Gln Asp Ala Lys Ala Ala Tyr 
            260                 265                 270         


Asp Ala Gly Ala Ile Tyr Gly Gly Leu Ile Phe Val Ala Thr Ser Pro 
        275                 280                 285             


Arg Cys Val Asn Val Glu Gln Ala Gln Glu Val Met Ala Ala Ala Pro 
    290                 295                 300                 


Leu Gln Tyr Val Gly Val Phe Arg Asn His Asp Ile Ala Asp Val Ala 
305                 310                 315                 320 


Asp Lys Ala Lys Val Leu Ser Leu Ala Ala Val Gln Leu His Gly Asn 
                325                 330                 335     


Glu Asp Gln Leu Tyr Ile Asp Asn Leu Arg Glu Ala Leu Pro Ala His 
            340                 345                 350         


Val Ala Ile Trp Lys Ala Leu Ser Val Gly Glu Thr Leu Pro Ala Arg 
        355                 360                 365             


Asp Phe Gln His Ile Asp Lys Tyr Val Phe Asp Asn Gly Gln Gly Gly 
    370                 375                 380                 


Ser Gly Gln Arg Phe Asp Trp Ser Leu Leu Asn Gly Gln Ser Leu Gly 
385                 390                 395                 400 


Asn Val Leu Leu Ala Gly Gly Leu Gly Ala Asp Asn Cys Val Glu Ala 
                405                 410                 415     


Ala Gln Thr Gly Cys Ala Gly Leu Asp Phe Asn Ser Ala Val Glu Ser 
            420                 425                 430         


Gln Pro Gly Ile Lys Asp Ala Arg Leu Leu Ala Ser Val Phe Gln Thr 
        435                 440                 445             


Leu Arg Ala Tyr 
    450         


<210> 58
<211> 397
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="TrpB"

<400> 58
Met Thr Thr Leu Leu Asn Pro Tyr Phe Gly Glu Phe Gly Gly Met Tyr 
1               5                   10                  15      


Val Pro Gln Ile Leu Met Pro Ala Leu Arg Gln Leu Glu Glu Ala Phe 
            20                  25                  30          


Val Ser Ala Gln Lys Asp Pro Glu Phe Gln Ala Gln Phe Asn Asp Leu 
        35                  40                  45              


Leu Lys Asn Tyr Ala Gly Arg Pro Thr Ala Leu Thr Lys Cys Gln Asn 
    50                  55                  60                  


Ile Thr Ala Gly Thr Asn Thr Thr Leu Tyr Leu Lys Arg Glu Asp Leu 
65                  70                  75                  80  


Leu His Gly Gly Ala His Lys Thr Asn Gln Val Leu Gly Gln Ala Leu 
                85                  90                  95      


Leu Ala Lys Arg Met Gly Lys Thr Glu Ile Ile Ala Glu Thr Gly Ala 
            100                 105                 110         


Gly Gln His Gly Val Ala Ser Ala Leu Ala Ser Ala Leu Leu Gly Leu 
        115                 120                 125             


Lys Cys Arg Ile Tyr Met Gly Ala Lys Asp Val Glu Arg Gln Ser Pro 
    130                 135                 140                 


Asn Val Phe Arg Met Arg Leu Met Gly Ala Glu Val Ile Pro Val His 
145                 150                 155                 160 


Ser Gly Ser Ala Thr Leu Lys Asp Ala Cys Asn Glu Ala Leu Arg Asp 
                165                 170                 175     


Trp Ser Gly Ser Tyr Glu Thr Ala His Tyr Met Leu Gly Thr Ala Ala 
            180                 185                 190         


Gly Pro His Pro Tyr Pro Thr Ile Val Arg Glu Phe Gln Arg Met Ile 
        195                 200                 205             


Gly Glu Glu Thr Lys Ala Gln Ile Leu Glu Arg Glu Gly Arg Leu Pro 
    210                 215                 220                 


Asp Ala Val Ile Ala Cys Val Gly Gly Gly Ser Asn Ala Ile Gly Met 
225                 230                 235                 240 


Phe Ala Asp Phe Ile Asn Glu Thr Asp Val Gly Leu Ile Gly Val Glu 
                245                 250                 255     


Pro Gly Gly His Gly Ile Glu Thr Gly Glu His Gly Ala Pro Leu Lys 
            260                 265                 270         


His Gly Arg Val Gly Ile Tyr Phe Gly Met Lys Ala Pro Met Met Gln 
        275                 280                 285             


Thr Glu Asp Gly Gln Ile Glu Glu Ser Tyr Ser Ile Ser Ala Gly Leu 
    290                 295                 300                 


Asp Phe Pro Ser Val Gly Pro Gln His Ala Tyr Leu Asn Ser Thr Gly 
305                 310                 315                 320 


Arg Ala Asp Tyr Val Ser Ile Thr Asp Asp Glu Ala Leu Glu Ala Phe 
                325                 330                 335     


Lys Thr Leu Cys Leu His Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser 
            340                 345                 350         


His Ala Leu Ala His Ala Leu Lys Met Met Arg Glu Asn Pro Glu Lys 
        355                 360                 365             


Glu Gln Leu Leu Val Val Asn Leu Ser Gly Arg Gly Asp Lys Asp Ile 
    370                 375                 380                 


Phe Thr Val His Asp Ile Leu Lys Ala Arg Gly Glu Ile 
385                 390                 395         


<210> 59
<211> 268
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="TrpA"

<400> 59
Met Glu Arg Tyr Glu Ser Leu Phe Ala Gln Leu Lys Glu Arg Lys Glu 
1               5                   10                  15      


Gly Ala Phe Val Pro Phe Val Thr Leu Gly Asp Pro Gly Ile Glu Gln 
            20                  25                  30          


Ser Leu Lys Ile Ile Asp Thr Leu Ile Glu Ala Gly Ala Asp Ala Leu 
        35                  40                  45              


Glu Leu Gly Ile Pro Phe Ser Asp Pro Leu Ala Asp Gly Pro Thr Ile 
    50                  55                  60                  


Gln Asn Ala Thr Leu Arg Ala Phe Ala Ala Gly Val Thr Pro Ala Gln 
65                  70                  75                  80  


Cys Phe Glu Met Leu Ala Leu Ile Arg Gln Lys His Pro Thr Ile Pro 
                85                  90                  95      


Ile Gly Leu Leu Met Tyr Ala Asn Leu Val Phe Asn Lys Gly Ile Asp 
            100                 105                 110         


Glu Phe Tyr Ala Glu Cys Glu Lys Val Gly Val Asp Ser Val Leu Val 
        115                 120                 125             


Ala Asp Val Pro Val Glu Glu Ser Ala Pro Phe Arg Gln Ala Ala Leu 
    130                 135                 140                 


Arg His Asn Val Ala Pro Ile Phe Ile Cys Pro Pro Asn Ala Asp Asp 
145                 150                 155                 160 


Asp Leu Leu Arg Gln Ile Ala Ser Tyr Gly Arg Gly Tyr Thr Tyr Leu 
                165                 170                 175     


Leu Ser Arg Ala Gly Val Thr Gly Ala Glu Asn Arg Ala Ala Leu Pro 
            180                 185                 190         


Leu Asn His Leu Val Ala Lys Leu Lys Glu Tyr Asn Ala Ala Pro Pro 
        195                 200                 205             


Leu Gln Gly Phe Gly Ile Ser Ala Pro Asp Gln Val Lys Ala Ala Ile 
    210                 215                 220                 


Asp Ala Gly Ala Ala Gly Ala Ile Ser Gly Ser Ala Ile Val Lys Ile 
225                 230                 235                 240 


Ile Glu Gln His Ile Asn Glu Pro Glu Lys Met Leu Ala Ala Leu Lys 
                245                 250                 255     


Ala Phe Val Gln Pro Met Lys Ala Ala Thr Arg Ser 
            260                 265             


<210> 60
<211> 350
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="AroGfbr: feedback resistant 
      2-dehydro-3-deoxyphosphoheptonate aldolase from E. coli"

<400> 60
Met Asn Tyr Gln Asn Asp Asp Leu Arg Ile Lys Glu Ile Lys Glu Leu 
1               5                   10                  15      


Leu Pro Pro Val Ala Leu Leu Glu Lys Phe Pro Ala Thr Glu Asn Ala 
            20                  25                  30          


Ala Asn Thr Val Ala His Ala Arg Lys Ala Ile His Lys Ile Leu Lys 
        35                  40                  45              


Gly Asn Asp Asp Arg Leu Leu Val Val Ile Gly Pro Cys Ser Ile His 
    50                  55                  60                  


Asp Pro Val Ala Ala Lys Glu Tyr Ala Thr Arg Leu Leu Thr Leu Arg 
65                  70                  75                  80  


Glu Glu Leu Gln Asp Glu Leu Glu Ile Val Met Arg Val Tyr Phe Glu 
                85                  90                  95      


Lys Pro Arg Thr Thr Val Gly Trp Lys Gly Leu Ile Asn Asp Pro His 
            100                 105                 110         


Met Asp Asn Ser Phe Gln Ile Asn Asp Gly Leu Arg Ile Ala Arg Lys 
        115                 120                 125             


Leu Leu Leu Asp Ile Asn Asp Ser Gly Leu Pro Ala Ala Gly Glu Phe 
    130                 135                 140                 


Leu Asp Met Ile Thr Leu Gln Tyr Leu Ala Asp Leu Met Ser Trp Gly 
145                 150                 155                 160 


Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Glu Leu Ala 
                165                 170                 175     


Ser Gly Leu Ser Cys Pro Val Gly Phe Lys Asn Gly Thr Asp Gly Thr 
            180                 185                 190         


Ile Lys Val Ala Ile Asp Ala Ile Asn Ala Ala Gly Ala Pro His Cys 
        195                 200                 205             


Phe Leu Ser Val Thr Lys Trp Gly His Ser Ala Ile Val Asn Thr Ser 
    210                 215                 220                 


Gly Asn Gly Asp Cys His Ile Ile Leu Arg Gly Gly Lys Glu Pro Asn 
225                 230                 235                 240 


Tyr Ser Ala Lys His Val Ala Glu Val Lys Glu Gly Leu Asn Lys Ala 
                245                 250                 255     


Gly Leu Pro Ala Gln Val Met Ile Asp Phe Ser His Ala Asn Ser Ser 
            260                 265                 270         


Lys Gln Phe Lys Lys Gln Met Asp Val Cys Thr Asp Val Cys Gln Gln 
        275                 280                 285             


Ile Ala Gly Gly Glu Lys Ala Ile Ile Gly Val Met Val Glu Ser His 
    290                 295                 300                 


Leu Val Glu Gly Asn Gln Ser Leu Glu Ser Gly Glu Pro Leu Ala Tyr 
305                 310                 315                 320 


Gly Lys Ser Ile Thr Asp Ala Cys Ile Gly Trp Asp Asp Thr Asp Ala 
                325                 330                 335     


Leu Leu Arg Gln Leu Ala Ser Ala Val Lys Ala Arg Arg Gly 
            340                 345                 350 


<210> 61
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="TrpEfbr: feedback resistant anthranilate synthase
      component I from E. coli"

<400> 61
Met Gln Thr Gln Lys Pro Thr Leu Glu Leu Leu Thr Cys Glu Gly Ala 
1               5                   10                  15      


Tyr Arg Asp Asn Pro Thr Ala Leu Phe His Gln Leu Cys Gly Asp Arg 
            20                  25                  30          


Pro Ala Thr Leu Leu Leu Glu Phe Ala Asp Ile Asp Ser Lys Asp Asp 
        35                  40                  45              


Leu Lys Ser Leu Leu Leu Val Asp Ser Ala Leu Arg Ile Thr Ala Leu 
    50                  55                  60                  


Ser Asp Thr Val Thr Ile Gln Ala Leu Ser Gly Asn Gly Glu Ala Leu 
65                  70                  75                  80  


Leu Thr Leu Leu Asp Asn Ala Leu Pro Ala Gly Val Glu Asn Glu Gln 
                85                  90                  95      


Ser Pro Asn Cys Arg Val Leu Arg Phe Pro Pro Val Ser Pro Leu Leu 
            100                 105                 110         


Asp Glu Asp Ala Arg Leu Cys Ser Leu Ser Val Phe Asp Ala Phe Arg 
        115                 120                 125             


Leu Leu Gln Asn Leu Leu Asn Val Pro Lys Glu Glu Arg Glu Ala Met 
    130                 135                 140                 


Phe Phe Gly Gly Leu Phe Ser Tyr Asp Leu Val Ala Gly Phe Glu Asn 
145                 150                 155                 160 


Leu Pro Gln Leu Ser Ala Glu Asn Ser Cys Pro Asp Phe Cys Phe Tyr 
                165                 170                 175     


Leu Ala Glu Thr Leu Met Val Ile Asp His Gln Lys Lys Ser Thr Arg 
            180                 185                 190         


Ile Gln Ala Ser Leu Phe Ala Pro Asn Glu Glu Glu Lys Gln Arg Leu 
        195                 200                 205             


Thr Ala Arg Leu Asn Glu Leu Arg Gln Gln Leu Thr Glu Ala Ala Pro 
    210                 215                 220                 


Pro Leu Pro Val Val Ser Val Pro His Met Arg Cys Glu Cys Asn Gln 
225                 230                 235                 240 


Ser Asp Glu Glu Phe Gly Gly Val Val Arg Leu Leu Gln Lys Ala Ile 
                245                 250                 255     


Arg Ala Gly Glu Ile Phe Gln Val Val Pro Ser Arg Arg Phe Ser Leu 
            260                 265                 270         


Pro Cys Pro Ser Pro Leu Ala Ala Tyr Tyr Val Leu Lys Lys Ser Asn 
        275                 280                 285             


Pro Ser Pro Tyr Met Phe Phe Met Gln Asp Asn Asp Phe Thr Leu Phe 
    290                 295                 300                 


Gly Ala Ser Pro Glu Ser Ser Leu Lys Tyr Asp Ala Thr Ser Arg Gln 
305                 310                 315                 320 


Ile Glu Ile Tyr Pro Ile Ala Gly Thr Arg Pro Arg Gly Arg Arg Ala 
                325                 330                 335     


Asp Gly Ser Leu Asp Arg Asp Leu Asp Ser Arg Ile Glu Leu Glu Met 
            340                 345                 350         


Arg Thr Asp His Lys Glu Leu Ser Glu His Leu Met Leu Val Asp Leu 
        355                 360                 365             


Ala Arg Asn Asp Leu Ala Arg Ile Cys Thr Pro Gly Ser Arg Tyr Val 
    370                 375                 380                 


Ala Asp Leu Thr Lys Val Asp Arg Tyr Ser Tyr Val Met His Leu Val 
385                 390                 395                 400 


Ser Arg Val Val Gly Glu Leu Arg His Asp Leu Asp Ala Leu His Ala 
                405                 410                 415     


Tyr Arg Ala Cys Met Asn Met Gly Thr Leu Ser Gly Ala Pro Lys Val 
            420                 425                 430         


Arg Ala Met Gln Leu Ile Ala Glu Ala Glu Gly Arg Arg Arg Gly Ser 
        435                 440                 445             


Tyr Gly Gly Ala Val Gly Tyr Phe Thr Ala His Gly Asp Leu Asp Thr 
    450                 455                 460                 


Cys Ile Val Ile Arg Ser Ala Leu Val Glu Asn Gly Ile Ala Thr Val 
465                 470                 475                 480 


Gln Ala Gly Ala Gly Val Val Leu Asp Ser Val Pro Gln Ser Glu Ala 
                485                 490                 495     


Asp Glu Thr Arg Asn Lys Ala Arg Ala Val Leu Arg Ala Ile Ala Thr 
            500                 505                 510         


Ala His His Ala Gln Glu Thr Phe 
        515                 520 


<210> 62
<211> 410
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="SerA: 2-oxoglutarate reductase from E. coli Nissle"

<400> 62
Met Ala Lys Val Ser Leu Glu Lys Asp Lys Ile Lys Phe Leu Leu Val 
1               5                   10                  15      


Glu Gly Val His Gln Lys Ala Leu Glu Ser Leu Arg Ala Ala Gly Tyr 
            20                  25                  30          


Thr Asn Ile Glu Phe His Lys Gly Ala Leu Asp Asp Glu Gln Leu Lys 
        35                  40                  45              


Glu Ser Ile Arg Asp Ala His Phe Ile Gly Leu Arg Ser Arg Thr His 
    50                  55                  60                  


Leu Thr Glu Asp Val Ile Asn Ala Ala Glu Lys Leu Val Ala Ile Gly 
65                  70                  75                  80  


Cys Phe Cys Ile Gly Thr Asn Gln Val Asp Leu Asp Ala Ala Ala Lys 
                85                  90                  95      


Arg Gly Ile Pro Val Phe Asn Ala Pro Phe Ser Asn Thr Arg Ser Val 
            100                 105                 110         


Ala Glu Leu Val Ile Gly Glu Leu Leu Leu Leu Leu Arg Gly Val Pro 
        115                 120                 125             


Glu Ala Asn Ala Lys Ala His Arg Gly Val Trp Asn Lys Leu Ala Ala 
    130                 135                 140                 


Gly Ser Phe Glu Ala Arg Gly Lys Lys Leu Gly Ile Ile Gly Tyr Gly 
145                 150                 155                 160 


His Ile Gly Thr Gln Leu Gly Ile Leu Ala Glu Ser Leu Gly Met Tyr 
                165                 170                 175     


Val Tyr Phe Tyr Asp Ile Glu Asn Lys Leu Pro Leu Gly Asn Ala Thr 
            180                 185                 190         


Gln Val Gln His Leu Ser Asp Leu Leu Asn Met Ser Asp Val Val Ser 
        195                 200                 205             


Leu His Val Pro Glu Asn Pro Ser Thr Lys Asn Met Met Gly Ala Lys 
    210                 215                 220                 


Glu Ile Ser Leu Met Lys Pro Gly Ser Leu Leu Ile Asn Ala Ser Arg 
225                 230                 235                 240 


Gly Thr Val Val Asp Ile Pro Ala Leu Cys Asp Ala Leu Ala Ser Lys 
                245                 250                 255     


His Leu Ala Gly Ala Ala Ile Asp Val Phe Pro Thr Glu Pro Ala Thr 
            260                 265                 270         


Asn Ser Asp Pro Phe Thr Ser Pro Leu Cys Glu Phe Asp Asn Val Leu 
        275                 280                 285             


Leu Thr Pro His Ile Gly Gly Ser Thr Gln Glu Ala Gln Glu Asn Ile 
    290                 295                 300                 


Gly Leu Glu Val Ala Gly Lys Leu Ile Lys Tyr Ser Asp Asn Gly Ser 
305                 310                 315                 320 


Thr Leu Ser Ala Val Asn Phe Pro Glu Val Ser Leu Pro Leu His Gly 
                325                 330                 335     


Gly Arg Arg Leu Met His Ile His Glu Asn Arg Pro Gly Val Leu Thr 
            340                 345                 350         


Ala Leu Asn Lys Ile Phe Ala Glu Gln Gly Val Asn Ile Ala Ala Gln 
        355                 360                 365             


Tyr Leu Gln Thr Ser Ala Gln Met Gly Tyr Val Val Ile Asp Ile Glu 
    370                 375                 380                 


Ala Asp Glu Asp Val Ala Glu Lys Ala Leu Gln Ala Met Lys Ala Ile 
385                 390                 395                 400 


Pro Gly Thr Ile Arg Ala Arg Leu Leu Tyr 
                405                 410 


<210> 63
<211> 410
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="SerAfbr: feedback resistant 2-oxoglutarate reductase
      from E. coli Nissle"

<400> 63
Met Ala Lys Val Ser Leu Glu Lys Asp Lys Ile Lys Phe Leu Leu Val 
1               5                   10                  15      


Glu Gly Val His Gln Lys Ala Leu Glu Ser Leu Arg Ala Ala Gly Tyr 
            20                  25                  30          


Thr Asn Ile Glu Phe His Lys Gly Ala Leu Asp Asp Glu Gln Leu Lys 
        35                  40                  45              


Glu Ser Ile Arg Asp Ala His Phe Ile Gly Leu Arg Ser Arg Thr His 
    50                  55                  60                  


Leu Thr Glu Asp Val Ile Asn Ala Ala Glu Lys Leu Val Ala Ile Gly 
65                  70                  75                  80  


Cys Phe Cys Ile Gly Thr Asn Gln Val Asp Leu Asp Ala Ala Ala Lys 
                85                  90                  95      


Arg Gly Ile Pro Val Phe Asn Ala Pro Phe Ser Asn Thr Arg Ser Val 
            100                 105                 110         


Ala Glu Leu Val Ile Gly Glu Leu Leu Leu Leu Leu Arg Gly Val Pro 
        115                 120                 125             


Glu Ala Asn Ala Lys Ala His Arg Gly Val Trp Asn Lys Leu Ala Ala 
    130                 135                 140                 


Gly Ser Phe Glu Ala Arg Gly Lys Lys Leu Gly Ile Ile Gly Tyr Gly 
145                 150                 155                 160 


His Ile Gly Thr Gln Leu Gly Ile Leu Ala Glu Ser Leu Gly Met Tyr 
                165                 170                 175     


Val Tyr Phe Tyr Asp Ile Glu Asn Lys Leu Pro Leu Gly Asn Ala Thr 
            180                 185                 190         


Gln Val Gln His Leu Ser Asp Leu Leu Asn Met Ser Asp Val Val Ser 
        195                 200                 205             


Leu His Val Pro Glu Asn Pro Ser Thr Lys Asn Met Met Gly Ala Lys 
    210                 215                 220                 


Glu Ile Ser Leu Met Lys Pro Gly Ser Leu Leu Ile Asn Ala Ser Arg 
225                 230                 235                 240 


Gly Thr Val Val Asp Ile Pro Ala Leu Cys Asp Ala Leu Ala Ser Lys 
                245                 250                 255     


His Leu Ala Gly Ala Ala Ile Asp Val Phe Pro Thr Glu Pro Ala Thr 
            260                 265                 270         


Asn Ser Asp Pro Phe Thr Ser Pro Leu Cys Glu Phe Asp Asn Val Leu 
        275                 280                 285             


Leu Thr Pro His Ile Gly Gly Ser Thr Gln Glu Ala Gln Glu Asn Ile 
    290                 295                 300                 


Gly Leu Glu Val Ala Gly Lys Leu Ile Lys Tyr Ser Asp Asn Gly Ser 
305                 310                 315                 320 


Thr Leu Ser Ala Val Asn Phe Pro Glu Val Ser Leu Pro Leu His Gly 
                325                 330                 335     


Gly Arg Arg Leu Met His Ile Ala Glu Ala Arg Pro Gly Val Leu Thr 
            340                 345                 350         


Ala Leu Asn Lys Ile Phe Ala Glu Gln Gly Val Asn Ile Ala Ala Gln 
        355                 360                 365             


Tyr Leu Gln Thr Ser Ala Gln Met Gly Tyr Val Val Ile Asp Ile Glu 
    370                 375                 380                 


Ala Asp Glu Asp Val Ala Glu Lys Ala Leu Gln Ala Met Lys Ala Ile 
385                 390                 395                 400 


Pro Gly Thr Ile Arg Ala Arg Leu Leu Tyr 
                405                 410 


<210> 64
<211> 471
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="TnaA: tryptophanase from E. coli"

<400> 64
Met Glu Asn Phe Lys His Leu Pro Glu Pro Phe Arg Ile Arg Val Ile 
1               5                   10                  15      


Glu Pro Val Lys Arg Thr Thr Arg Ala Tyr Arg Glu Glu Ala Ile Ile 
            20                  25                  30          


Lys Ser Gly Met Asn Pro Phe Leu Leu Asp Ser Glu Asp Val Phe Ile 
        35                  40                  45              


Asp Leu Leu Thr Asp Ser Gly Thr Gly Ala Val Thr Gln Ser Met Gln 
    50                  55                  60                  


Ala Ala Met Met Arg Gly Asp Glu Ala Tyr Ser Gly Ser Arg Ser Tyr 
65                  70                  75                  80  


Tyr Ala Leu Ala Glu Ser Val Lys Asn Ile Phe Gly Tyr Gln Tyr Thr 
                85                  90                  95      


Ile Pro Thr His Gln Gly Arg Gly Ala Glu Gln Ile Tyr Ile Pro Val 
            100                 105                 110         


Leu Ile Lys Lys Arg Glu Gln Glu Lys Gly Leu Asp Arg Ser Lys Met 
        115                 120                 125             


Val Ala Phe Ser Asn Tyr Phe Phe Asp Thr Thr Gln Gly His Ser Gln 
    130                 135                 140                 


Ile Asn Gly Cys Thr Val Arg Asn Val Tyr Ile Lys Glu Ala Phe Asp 
145                 150                 155                 160 


Thr Gly Val Arg Tyr Asp Phe Lys Gly Asn Phe Asp Leu Glu Gly Leu 
                165                 170                 175     


Glu Arg Gly Ile Glu Glu Val Gly Pro Asn Asn Val Pro Tyr Ile Val 
            180                 185                 190         


Ala Thr Ile Thr Ser Asn Ser Ala Gly Gly Gln Pro Val Ser Leu Ala 
        195                 200                 205             


Asn Leu Lys Val Met Tyr Ser Ile Ala Lys Lys Tyr Asp Ile Pro Val 
    210                 215                 220                 


Val Met Asp Ser Ala Arg Phe Ala Glu Asn Ala Tyr Phe Ile Lys Gln 
225                 230                 235                 240 


Arg Glu Ala Glu Tyr Lys Asp Trp Thr Ile Glu Gln Ile Thr Arg Glu 
                245                 250                 255     


Thr Tyr Lys Tyr Ala Asp Met Leu Ala Met Ser Ala Lys Lys Asp Ala 
            260                 265                 270         


Met Val Pro Met Gly Gly Leu Leu Cys Met Lys Asp Asp Ser Phe Phe 
        275                 280                 285             


Asp Val Tyr Thr Glu Cys Arg Thr Leu Cys Val Val Gln Glu Gly Phe 
    290                 295                 300                 


Pro Thr Tyr Gly Gly Leu Glu Gly Gly Ala Met Glu Arg Leu Ala Val 
305                 310                 315                 320 


Gly Leu Tyr Asp Gly Met Asn Leu Asp Trp Leu Ala Tyr Arg Ile Ala 
                325                 330                 335     


Gln Val Gln Tyr Leu Val Asp Gly Leu Glu Glu Ile Gly Val Val Cys 
            340                 345                 350         


Gln Gln Ala Gly Gly His Ala Ala Phe Val Asp Ala Gly Lys Leu Leu 
        355                 360                 365             


Pro His Ile Pro Ala Asp Gln Phe Pro Ala Gln Ala Leu Ala Cys Glu 
    370                 375                 380                 


Leu Tyr Lys Val Ala Gly Ile Arg Ala Val Glu Ile Gly Ser Phe Leu 
385                 390                 395                 400 


Leu Gly Arg Asp Pro Lys Thr Gly Lys Gln Leu Pro Cys Pro Ala Glu 
                405                 410                 415     


Leu Leu Arg Leu Thr Ile Pro Arg Ala Thr Tyr Thr Gln Thr His Met 
            420                 425                 430         


Asp Phe Ile Ile Glu Ala Phe Lys His Val Lys Glu Asn Ala Ala Asn 
        435                 440                 445             


Ile Lys Gly Leu Thr Phe Thr Tyr Glu Pro Lys Val Leu Arg His Phe 
    450                 455                 460                 


Thr Ala Lys Leu Lys Glu Val 
465                 470     


<210> 65
<211> 416
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Pseudomonas kynureninase, P83788"

<400> 65
Met Thr Thr Arg Asn Asp Cys Leu Ala Leu Asp Ala Gln Asp Ser Leu 
1               5                   10                  15      


Ala Pro Leu Arg Gln Gln Phe Ala Leu Pro Glu Gly Val Ile Tyr Leu 
            20                  25                  30          


Asp Gly Asn Ser Leu Gly Ala Arg Pro Val Ala Ala Leu Ala Arg Ala 
        35                  40                  45              


Gln Ala Val Ile Ala Glu Glu Trp Gly Asn Gly Leu Ile Arg Ser Trp 
    50                  55                  60                  


Asn Ser Ala Gly Trp Arg Asp Leu Ser Glu Arg Leu Gly Asn Arg Leu 
65                  70                  75                  80  


Ala Thr Leu Ile Gly Ala Arg Asp Gly Glu Val Val Val Thr Asp Thr 
                85                  90                  95      


Thr Ser Ile Asn Leu Phe Lys Val Leu Ser Ala Ala Leu Arg Val Gln 
            100                 105                 110         


Ala Thr Arg Ser Pro Glu Arg Arg Val Ile Val Thr Glu Thr Ser Asn 
        115                 120                 125             


Phe Pro Thr Asp Leu Tyr Ile Ala Glu Gly Leu Ala Asp Met Leu Gln 
    130                 135                 140                 


Gln Gly Tyr Thr Leu Arg Leu Val Asp Ser Pro Glu Glu Leu Pro Gln 
145                 150                 155                 160 


Ala Ile Asp Gln Asp Thr Ala Val Val Met Leu Thr His Val Asn Tyr 
                165                 170                 175     


Lys Thr Gly Tyr Met His Asp Met Gln Ala Leu Thr Ala Leu Ser His 
            180                 185                 190         


Glu Cys Gly Ala Leu Ala Ile Trp Asp Leu Ala His Ser Ala Gly Ala 
        195                 200                 205             


Val Pro Val Asp Leu His Gln Ala Gly Ala Asp Tyr Ala Ile Gly Cys 
    210                 215                 220                 


Thr Tyr Lys Tyr Leu Asn Gly Gly Pro Gly Ser Gln Ala Phe Val Trp 
225                 230                 235                 240 


Val Ser Pro Gln Leu Cys Asp Leu Val Pro Gln Pro Leu Ser Gly Trp 
                245                 250                 255     


Phe Gly His Ser Arg Gln Phe Ala Met Glu Pro Arg Tyr Glu Pro Ser 
            260                 265                 270         


Asn Gly Ile Ala Arg Tyr Leu Cys Gly Thr Gln Pro Ile Thr Ser Leu 
        275                 280                 285             


Ala Met Val Glu Cys Gly Leu Asp Val Phe Ala Gln Thr Asp Met Ala 
    290                 295                 300                 


Ser Leu Arg Arg Lys Ser Leu Ala Leu Thr Asp Leu Phe Ile Glu Leu 
305                 310                 315                 320 


Val Glu Gln Arg Cys Ala Ala His Glu Leu Thr Leu Val Thr Pro Arg 
                325                 330                 335     


Glu His Ala Lys Arg Gly Ser His Val Ser Phe Glu His Pro Glu Gly 
            340                 345                 350         


Tyr Ala Val Ile Gln Ala Leu Ile Asp Arg Gly Val Ile Gly Asp Tyr 
        355                 360                 365             


Arg Glu Pro Arg Ile Met Arg Phe Gly Phe Thr Pro Leu Tyr Thr Thr 
    370                 375                 380                 


Phe Thr Glu Val Trp Asp Ala Val Gln Ile Leu Gly Glu Ile Leu Asp 
385                 390                 395                 400 


Arg Lys Thr Trp Ala Gln Ala Gln Phe Gln Val Arg His Ser Val Thr 
                405                 410                 415     


<210> 66
<211> 465
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Human, Q16719"

<400> 66
Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile 
1               5                   10                  15      


Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His 
            20                  25                  30          


Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile 
        35                  40                  45              


Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys 
    50                  55                  60                  


Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro 
65                  70                  75                  80  


Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys 
                85                  90                  95      


Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly 
            100                 105                 110         


Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu 
        115                 120                 125             


Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu 
    130                 135                 140                 


Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu 
145                 150                 155                 160 


Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu 
                165                 170                 175     


Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro 
            180                 185                 190         


Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile 
        195                 200                 205             


Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His 
    210                 215                 220                 


Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly 
225                 230                 235                 240 


Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly 
                245                 250                 255     


Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp 
            260                 265                 270         


Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala 
        275                 280                 285             


Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Leu Val Gly 
    290                 295                 300                 


Trp Phe Gly His Glu Leu Ser Thr Arg Phe Lys Met Asp Asn Lys Leu 
305                 310                 315                 320 


Gln Leu Ile Pro Gly Val Cys Gly Phe Arg Ile Ser Asn Pro Pro Ile 
                325                 330                 335     


Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Ile Phe Lys Gln Ala 
            340                 345                 350         


Thr Met Lys Ala Leu Arg Lys Lys Ser Val Leu Leu Thr Gly Tyr Leu 
        355                 360                 365             


Glu Tyr Leu Ile Lys His Asn Tyr Gly Lys Asp Lys Ala Ala Thr Lys 
    370                 375                 380                 


Lys Pro Val Val Asn Ile Ile Thr Pro Ser His Val Glu Glu Arg Gly 
385                 390                 395                 400 


Cys Gln Leu Thr Ile Thr Phe Ser Val Pro Asn Lys Asp Val Phe Gln 
                405                 410                 415     


Glu Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Asn Pro Asn Gly 
            420                 425                 430         


Ile Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val Tyr 
        435                 440                 445             


Lys Phe Thr Asn Leu Leu Thr Ser Ile Leu Asp Ser Ala Glu Thr Lys 
    450                 455                 460                 


Asn 
465 


<210> 67
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Shewanella, Q8E973"

<400> 67
Met Leu Leu Asn Val Lys Gln Asp Phe Cys Leu Ala Gly Pro Gly Tyr 
1               5                   10                  15      


Leu Leu Asn His Ser Val Gly Arg Pro Leu Lys Ser Thr Glu Gln Ala 
            20                  25                  30          


Leu Lys Gln Ala Phe Phe Ala Pro Trp Gln Glu Ser Gly Arg Glu Pro 
        35                  40                  45              


Trp Gly Gln Trp Leu Gly Val Ile Asp Asn Phe Thr Ala Ala Leu Ala 
    50                  55                  60                  


Ser Leu Phe Asn Gly Gln Pro Gln Asp Phe Cys Pro Gln Val Asn Leu 
65                  70                  75                  80  


Ser Ser Ala Leu Thr Lys Ile Val Met Ser Leu Asp Arg Leu Thr Arg 
                85                  90                  95      


Asp Leu Thr Arg Asn Gly Gly Ala Val Val Leu Met Ser Glu Ile Asp 
            100                 105                 110         


Phe Pro Ser Met Gly Phe Ala Leu Lys Lys Ala Leu Pro Ala Ser Cys 
        115                 120                 125             


Glu Leu Arg Phe Ile Pro Lys Ser Leu Asp Val Thr Asp Pro Asn Val 
    130                 135                 140                 


Trp Asp Ala His Ile Cys Asp Asp Val Asp Leu Val Phe Val Ser His 
145                 150                 155                 160 


Ala Tyr Ser Asn Thr Gly Gln Gln Ala Pro Leu Ala Gln Ile Ile Ser 
                165                 170                 175     


Leu Ala Arg Glu Arg Gly Cys Leu Ser Leu Val Asp Val Ala Gln Ser 
            180                 185                 190         


Ala Gly Ile Leu Pro Leu Asp Leu Ala Lys Leu Gln Pro Asp Phe Met 
        195                 200                 205             


Ile Gly Ser Ser Val Lys Trp Leu Cys Ser Gly Pro Gly Ala Ala Tyr 
    210                 215                 220                 


Leu Trp Val Asn Pro Ala Ile Leu Pro Glu Cys Gln Pro Gln Asp Val 
225                 230                 235                 240 


Gly Trp Phe Ser His Glu Asn Pro Phe Glu Phe Asp Ile His Asp Phe 
                245                 250                 255     


Arg Tyr His Pro Thr Ala Leu Arg Phe Trp Gly Gly Thr Pro Ser Ile 
            260                 265                 270         


Ala Pro Tyr Ala Ile Ala Ala His Ser Ile Glu Tyr Phe Ala Asn Ile 
        275                 280                 285             


Gly Ser Gln Val Met Arg Glu His Asn Leu Gln Leu Met Glu Pro Val 
    290                 295                 300                 


Val Gln Ala Leu Asp Asn Glu Leu Val Ser Pro Gln Glu Val Asp Lys 
305                 310                 315                 320 


Arg Ser Gly Thr Ile Ile Leu Gln Phe Gly Glu Arg Gln Pro Gln Ile 
                325                 330                 335     


Leu Ala Ala Leu Ala Ala Ala Asn Ile Ser Val Asp Thr Arg Ser Leu 
            340                 345                 350         


Gly Ile Arg Val Ser Pro His Ile Tyr Asn Asp Glu Ala Asp Ile Ala 
        355                 360                 365             


Arg Leu Leu Gly Val Ile Lys Ala Asn Arg 
    370                 375             


<210> 68
<211> 1303
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="kynU (Pseudomonas)"

<400> 68
atgacgaccc gaaatgattg cctagcgttg gatgcacagg acagtctggc tccgctgcgc       60

caacaatttg cgctgccgga gggtgtgata tacctggatg gcaattcgct gggcgcacgt      120

ccggtagctg cgctggctcg cgcgcaggct gtgatcgcag aagaatgggg caacgggttg      180

atccgttcat ggaactctgc gggctggcgt gatctgtctg aacgcctggg taatcgcctg      240

gctaccctga ttggtgcgcg cgatggggaa gtagttgtta ctgataccac ctcgattaat      300

ctgtttaaag tgctgtcagc ggcgctgcgc gtgcaagcta cccgtagccc ggagcgccgt      360

gttatcgtga ctgagacctc gaatttcccg accgacctgt atattgcgga agggttggcg      420

gatatgctgc aacaaggtta cactctgcgt ttggtggatt caccggaaga gctgccacag      480

gctatagatc aggacaccgc ggtggtgatg ctgacgcacg taaattataa aaccggttat      540

atgcacgaca tgcaggctct gaccgcgttg agccacgagt gtggggctct ggcgatttgg      600

gatctggcgc actctgctgg cgctgtgccg gtggacctgc accaagcggg cgcggactat      660

gcgattggct gcacgtacaa atacctgaat ggcggcccgg gttcgcaagc gtttgtttgg      720

gtttcgccgc aactgtgcga cctggtaccg cagccgctgt ctggttggtt cggccatagt      780

cgccaattcg cgatggagcc gcgctacgaa ccttctaacg gcattgctcg ctatctgtgc      840

ggcactcagc ctattactag cttggctatg gtggagtgcg gcctggatgt gtttgcgcag      900

acggatatgg cttcgctgcg ccgtaaaagt ctggcgctga ctgatctgtt catcgagctg      960

gttgaacaac gctgcgctgc acacgaactg accctggtta ctccacgtga acacgcgaaa     1020

cgcggctctc acgtgtcttt tgaacacccc gagggttacg ctgttattca agctctgatt     1080

gatcgtggcg tgatcggcga ttaccgtgag ccacgtatta tgcgtttcgg tttcactcct     1140

ctgtatacta cttttacgga agtttgggat gcagtacaaa tcctgggcga aatcctggat     1200

cgtaagactt gggcgcaggc tcagtttcag gtgcgccact ctgttactta aaaataaaac     1260

gaaaggctca gtcgaaagac tgggcctttc gttttatctg ttg                       1303


<210> 69
<211> 1450
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="kynU(Human)"

<400> 69
atggagcctt catctttaga actgccagcg gacacggtgc agcgcatcgc ggcggaactg       60

aagtgccatc cgactgatga gcgtgtggcg ctgcatctgg acgaagaaga taaactgcgc      120

cactttcgtg aatgttttta tattcctaaa attcaagact tgccgccggt agatttgagt      180

ctcgttaaca aagatgaaaa cgcgatctac tttctgggca actctctggg tctgcaacca      240

aaaatggtta aaacgtacct ggaggaagaa ctggataaat gggcaaaaat cgcggcttat      300

ggtcacgaag tgggcaagcg tccttggatt actggcgacg agtctattgt gggtttgatg      360

aaagatattg tgggcgcgaa tgaaaaggaa attgcactga tgaatgctct gaccgttaat      420

ctgcacctgc tgatgctgtc tttttttaaa ccgaccccga aacgctacaa aatactgctg      480

gaagcgaaag cgtttccgtc ggatcactat gctatagaaa gtcaactgca gttgcatggt      540

ctgaatatcg aggaatctat gcgcatgatt aaaccgcgtg agggtgaaga aacgctgcgt      600

attgaagaca ttctggaagt tattgaaaaa gaaggtgatt ctatcgcagt tatactgttt      660

tctggcgtgc acttttatac aggtcagcac ttcaatatcc cggcaatcac taaagcgggg      720

caggcaaaag gctgctatgt tggttttgac ctggcgcatg cagtggggaa tgttgaactg      780

tatctgcacg attggggcgt tgatttcgcg tgttggtgta gctacaaata tctgaacgct      840

ggcgcgggtg gcattgctgg cgcttttatt cacgaaaaac acgcgcacac cattaaaccg      900

gctctggttg gctggttcgg tcatgagctg agtactcgct ttaaaatgga taacaaactg      960

caattgattc cgggtgtttg cggcttccgt atcagcaatc cgccgattct gctggtttgc     1020

agcctgcacg ctagtctgga aatctttaag caggcgacta tgaaagcgct gcgcaaaaaa     1080

tctgtgctgc tgaccggcta tctggagtat ctgatcaaac acaattatgg caaagataaa     1140

gctgcaacta aaaaaccggt agtgaacatt atcaccccct cacacgtgga ggagcgcggt     1200

tgtcagctga ctattacttt cagtgtacct aataaagatg tgttccagga actggaaaaa     1260

cgcggcgttg tttgtgataa acgtaacccg aatggtattc gcgtggctcc tgtgccgctg     1320

tacaattcat tccacgatgt ttataaattc accaacctgc tgacttctat tctcgacagt     1380

gctgagacta aaaattaaaa ataaaacgaa aggctcagtc gaaagactgg gcctttcgtt     1440

ttatctgttg                                                            1450


<210> 70
<211> 1189
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="kynU(Shewanella)"

<400> 70
atgctgctga atgtaaaaca ggacttttgc ctggcaggcc cgggctacct gctgaatcac       60

tcggttggcc gtccgctgaa atcaactgag caagcgctga aacaagcatt ttttgctccg      120

tggcaagaga gcggtcgtga accgtggggc cagtggctgg gtgttattga taatttcact      180

gctgcgctgg catctctgtt taatggtcaa ccgcaggatt tttgtccgca ggttaacctg      240

agcagcgcgc tgactaaaat tgtgatgtca ctggatcgtc tgactcgcga tctgacccgc      300

aatggcggtg ctgttgtgct gatgtctgaa atcgatttcc catctatggg cttcgcgttg      360

aaaaaagcgc tgccagcgag ctgcgaactg cgttttatcc cgaaaagtct ggacgtgact      420

gatccgaacg tatgggatgc acacatctgt gatgatgtag acctggtttt tgtgtctcac      480

gcctatagta atacgggcca acaggctccg ctggcgcaaa tcatctctct ggcgcgtgaa      540

cgtggctgcc tgtcactggt ggatgtagcg caatcagcgg ggattttgcc gctggatctg      600

gcgaaactgc aaccggactt catgatcggc agttcggtta aatggctgtg ctcgggccct      660

ggtgcggcat atctgtgggt taatccggcg attctgccgg aatgtcagcc gcaggatgtg      720

ggctggtttt cacatgagaa tccctttgaa ttcgacatcc acgatttccg ctaccacccg      780

actgcactgc gcttttgggg tggtacgccg tcgatcgcgc cttatgcgat cgcggcgcac      840

tcgatcgaat attttgccaa tatcggctcg caagtgatgc gtgaacacaa cctgcaactg      900

atggaaccgg tggttcaggc gctggacaat gaactggtga gcccgcagga agtggataaa      960

cgctcaggca ctattattct gcaattcggt gaacgtcaac cgcaaattct ggcggctctg     1020

gctgcggcga acatttcggt ggacactcgt tctttgggga ttcgtgttag tccgcacatt     1080

tataatgatg aggcggacat tgcgcgcctg ctgggtgtga tcaaagcaaa tcgctaaaaa     1140

taaaacgaaa ggctcagtcg aaagactggg cctttcgttt tatctgttg                 1189


<210> 71
<211> 1242
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="nupC (polynucleotide)"

<400> 71
gtgcacggaa atttaacctg cctcatattt ggagcaaata tggaccgcgt ccttcatttt       60

gtactggcac ttgccgttgt tgcgattctc gcactgctgg taagcagcga ccgcaaaaaa      120

attcgtatcc gttatgttat tcaactgctt gttatcgaag tgttactggc gtggttcttc      180

ctgaactccg acgttggtct gggcttcgtg aaaggcttct ccgaaatgtt cgaaaaactg      240

ctcggttttg ccaacgaagg gactaacttc gtctttggta gcatgaatga tcaaggcctg      300

gcattcttct tcctgaaagt gctgtgccca atcgtcttta tctctgcgct gatcggtatt      360

ctccagcata ttcgcgtatt gccggtgatt atccgcgcaa ttggtttcct gctctccaaa      420

gtcaacggca tgggcaaact ggaatccttt aacgccgtca gctccctgat tctgggtcag      480

tctgaaaact ttattgccta taaagatatc ctcggcaaaa tctcccgcaa tcgtatgtac      540

accatggcag caacggcgat gtccaccgtg tcgatgtcca tcgttggtgc atatatgacc      600

atgctggagc cgaaatacgt cgttgcggcg ctggtactga acatgttcag cacctttatc      660

gtgctgtcgc tgatcaaccc ttaccgtgtt gatgccagtg aagaaaacat tcagatgtcc      720

aacctgcacg aaggtcagag cttcttcgaa atgctgggtg aatacattct ggcaggtttc      780

aaagttgcca ttatcgttgc cgcgatgctg atcggcttta tcgccctgat cgctgcactg      840

aacgctctgt ttgctaccgt gactggctgg tttggctaca gcatctcctt ccagggcatc      900

ctgggttaca tcttctatcc gattgcatgg gtgatgggtg ttccttccag tgaagcactg      960

caagtgggca gtatcatggc gaccaaactg gtttccaacg agttcgttgc gatgatggat     1020

ctgcagaaaa ttgcttccac gctctctccg cgtgcggaag gcatcatctc tgtgttcctg     1080

gtttccttcg ctaacttctc ttcaatcggg attatcgcgg gtgcggttaa aggcctgaat     1140

gaagagcaag gtaacgtggt ttctcgcttc ggtctgaaac tggtttacgg ctctaccctg     1200

gtgagtgtgc tgtctgcgtc aatcgcagca ctggtgctgt aa                        1242


<210> 72
<211> 2259
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="xdhA"

<400> 72
atgcgcgtcg atgccattgc taaggtcacc gggcgggcac gatatactga cgattatatt       60

atggcgggca tgtgttacgc gaaatatgta cgtagcccta tcgcacatgg ttatgctgta      120

aatattaatg atgaacaagc caggagtttg ccgggcgtcc tggcgatttt tacctgggaa      180

gatgtgccag aaatcccatt cgccacggca gggcatgcct ggacacttga cgaaaacaag      240

cgcgataccg ccgatcgtgc cctgctaacg cgtcatgttc gtcatcatgg tgacgccgtt      300

gccatcgtcg tggcccgcga tgaactcacg gcagaaaaag cggcgcaatt ggtcagcatt      360

gagtggcaag aattacccgt tatcacctcg ccagaagcgg cgctggcaga agacgctgca      420

ccaatccata acggtggcaa tttactgaaa caaagcacga tgtcgacggg taatgtccaa      480

caaacaatcg atgccgccga ctaccaggta caggggcact atcagactcc cgttattcaa      540

cattgtcata tggaaagcgt gacatcgctg gcatggatgg aggatgactc gcgaattacc      600

atcgtttcca gcacccagat cccgcacatt gttcgccgcg tggttggtca ggcgctggat      660

attccctggt catgcgtacg agtcatcaaa ccgtttatcg gtggcggttt tggtaataaa      720

caggatgtac tggaagagcc aatggcggca ttcctgacca gcaaacttgg cggcattccg      780

gtgaaagttt cccttagccg tgaagagtgt ttcctcgcaa cccgtacccg ccacgctttt      840

actattgacg ggcaaatggg cgtgaaccgc gacggaacat tgaaaggtta tagtctggat      900

gttctgtcta acaccggcgc ttatgcatct cacgggcact ccattgcttc tgctgggggg      960

aataaagtcg cttaccttta tcctcgttgt gcctacgctt acagttcaaa gacctgctat     1020

accaacctcc cctcggctgg tgcgatgcgt ggttatggcg cgccacaagt cgtatttgcc     1080

gttgagtcta tgcttgatga tgccgcgaca gcgttaggta ttgatcctgt tgaaattcgt     1140

ttacgcaacg ccgcccgcga aggagatgct aatccgctca cgggaaaacg tatttacagc     1200

gcagggttgc cggagtgtct tgaaaaaggc cggaaaatct ttgaatggga aaaacgccgt     1260

gcagagtgcc agaaccagca aggcaattta cgtcgtggcg ttggcgtcgc ctgttttagc     1320

tacacctcta acacctggcc tgtcggcgta gaaatagcag gcgcgcgcct gttgatgaat     1380

caggatggaa ccatcaacgt gcaaagcggc gcgacggaaa tcggccaggg tgccgacacc     1440

gtgttctcgc aaatggtggc agaaaccgtg ggagttccgg tcagcgatgt tcacgttatt     1500

tcaacccaag ataccgacgt tacaccattc gaccccggcg catttgcctc acgtcagagc     1560

tatgttgccg cgcctgcgct gcgcagtgca gcactgttat taaaagagaa aatcatcgct     1620

cacgccgcag tcatgctaca tcagtcagcg atgaatctga ccctgataaa aggccatatc     1680

gtgctgattg aaagaccgga agaaccgtta atgtcgttaa aagatttggc gatggacgct     1740

ttctaccacc ctgaacgcgg cgggcagctc tctgccgaaa gctccatcaa aaccaccact     1800

aacccaccgg cgtttggctg tacctttgtt gatctgacgg tcgatattgc actgtgcaaa     1860

gtcaccatca accgcatcct caacgttcat gattcgggcc atattcttaa tccgctgctg     1920

gcagaaggtc aggtacacgg cggaatggga atgggcattg gctgggcgct atttgaagag     1980

atgatcatcg atgcgaaaag cggcgtggtc cgtaacccca atctgctgga ttacaaaatg     2040

ccgaccatgc cggatctgcc acaactggaa agcgcgttcg tcgaaatcaa tgagccgcaa     2100

tcagcatacg gacataagtc actgggtgag ccccccataa ttcctgtagc cgctgctatt     2160

cgtaacgcgg tgaagatggc taccggtgtt gcaatcaata cactgccgct aacgccaaaa     2220

cgattatatg aagaattcca tctggcagga ttgatttga                            2259


<210> 73
<211> 879
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="xdhB"

<400> 73
atgtttgatt ttgcttctta ccatcgcgca accacccttg ccgatgccat caccctgctg       60

gctgacaatc cgcaggccaa attgcttgcc ggtggcactg acgtactgat acagcttcac      120

catcacaatg accgctatcg ccatattgtt gatatccaca atctggcaga gcttcaggga      180

ataacacagg cggaagatgg cgcgctgcga atcggctctg cgacaacatt tactcagctc      240

attgaagatc ccgtaatcca acgcaatctc ccggcgttat gtgctgcggc tgcatcaatc      300

gccgggccgc agatccgtaa tgtcgccacc tacggcggaa atatttgcaa cggtgccacc      360

agcgcagatt ctgccacgcc aacgctaatt tatgacgcga aactggagct ccactcccca      420

cgcggtgttc gtttcgtccc gattaatggc tttcacaccg ggccgggcaa agtgtctctt      480

gagcatgacg aaatccttgt cgcctttcat tttccgccac agccgaaaga acacgcgggc      540

agcgcgcatt ttaaatatgc catgcgcgac gcaatggata tttcaacaat tggctgcgcc      600

gcacattgcc gactggataa cggcaatttc agcgaattac gcctggcatt tggtgttgcc      660

gcgccaacgc cgattcgctg ccaacatgcc gaacagactg cacaaaatgc gccattaaac      720

ctgcaaacgc tggaagccat cagcgaatca gtcctgcaag atgtcgcccc gcgttcttca      780

tggcgggcca gtaaagagtt tcgtctgcat ctcatccaga cgatgaccaa aaaagtgatt      840

agcgaagccg tcgccgcggc ggggggaaaa ttgcaatga                             879


<210> 74
<211> 480
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="xdhC"

<400> 74
atgaatcaca gcgaaacaat taccatcgaa tgcaccatta acgggatgcc ttttcagctt       60

cacgccgcgc caggaatgcc gctttcggaa ctactccgag aacaagggct tcttagtgtc      120

aaacaaggtt gctgcgtagg cgaatgcggt gcctgtacgg tgctggtcga cggcactgcg      180

atagacagtt gcttattcct tgcgacctgg gctgaaggaa aagagatccg cacgctggaa      240

ggtgaagcga aaggcggtaa actttctcat gtccaactgg cttatgcgaa atctggtgca      300

gtgcaatgcg ggttttgtac gccgggcctg attatggcta ccacggcgat gctggcaaaa      360

ccacgcgaaa aaccattaac cattacggaa attcgtcgtg gactggcggg aaatctttgt      420

cgctgcacgg ggtatcagat gattgtaaat acagttctgg attgcgagaa aacgaagtaa      480


<210> 75
<211> 1002
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Add"

<400> 75
atgattgata ccaccctgcc attaactgat atccatcgcc accttgatgg caacattcgt       60

ccccagacca ttcttgaact tggccgccag tataatatct cgcttcctgc acaatccctg      120

gaaacactga ttccccacgt tcaggtcatt gccaacgaac ccgatctggt gagctttctg      180

actaaacttg actggggcgt taaagttctc gcctctcttg atgcctgccg ccgcgtggca      240

tttgaaaaca ttgaagatgc agcccgtaac ggcctgcact atgtcgagct gcgtttttca      300

ccaggctaca tggcaatggc acatcagctg cctgtagcgg gtgttgtcga agcggtgatc      360

gatggcgtac gtgaaggttg ccgcaccttt ggtgtgcagg cgaagcttat cggtattatg      420

agccggacct tcggcgaagc cgcctgtcag caagagctgg aggccttttt agcccaccgt      480

gaccagatta ccgcacttga tttagccggt gatgaacttg gtttcccggg aagtctgttc      540

ctttctcatt tcaaccgcgc gcgtgatgcg ggctggcata ttaccgtcca tgcaggcgaa      600

gctgccggac cggaaagcat ctggcaggcg attcgtgaac tgggggcgga gcgtattgga      660

catggcgtaa aagccattga agatcgggcg ctgatggatt ttctcgccga gcaacaaatt      720

ggtattgaat cctgtctgac ctccaatatt cagaccagca ccgtggcgga tctggctgca      780

catccgctga aaacgttcct tgagcatggc attcgtgcca gcattaacac tgacgatcca      840

ggcgtgcagg gagtggatat cattcacgaa tataccgttg ccgcgccagc tgctgggtta      900

tcccgcgagc aaatccgcca ggcacagatt aatggtctgg aaatggcttt cctcagcgca      960

gaggaaaaac gcgcactgcg agaaaaagtc gccgcgaagt aa                        1002


<210> 76
<211> 834
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="xapA"

<400> 76
atgtatcagg ctcagttttc tcataaccca ctgtattgcg tagatattat caagacttat       60

aaacctgatt tcacgccacg agtggccttt attttaggtt ccgggctggg cgcgctggcc      120

gatcagattg agaacgcggt cgcaatttcc tacgaaaagc tgcctgggtt cccggtaagt      180

accgtacacg gtcatgcggg tgagctggtg ctgggttatc tccagggggt gccagtggcg      240

tgtatgaaag gtcgcggaca tttctacgaa ggtcgtggga tgaccatcat gacggatgca      300

atccgtacct ttaagttgct gggctgcgag ttgctgttct gcaccaatgc ggctggctca      360

ctgcgccctg aagtgggggc cggcagtctg gtcgcattga aagatcacat caacaccatg      420

ccgggaacgc cgatggtggg tcttaatgat gaacgttttg gtgagcgctt cttctcgctg      480

gcgaatgcct acgatgcgga ataccgcgca ctgttacaaa aagtggcgaa agaagagggg      540

ttccctctga cggagggcgt gttcgtctca tatccggggc cgaatttcga gactgcggcg      600

gaaattcgca tgatgcaaat tattggtggg gatgttgttg gtatgtctgt ggtgcctgag      660

gttatttcag ctcgccattg cgaacttaaa gtcgttgcgg tctctgcgat taccaacatg      720

gcggaaggtc tgagtgacgt gaagctttct catgcccaaa cgctggcagc agcggaactc      780

tcaaagcaaa actttattaa tcttatttgc ggctttctgc gcaaaattgc ctga            834


<210> 77
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="deoD"

<400> 77
atggctaccc cacacattaa tgcagaaatg ggcgatttcg ctgacgtagt tttgatgcca       60

ggcgacccgc tgcgtgcgaa gtatattgct gaaactttcc ttgaagatgc ccgtgaagtg      120

aacaacgttc gcggtatgct gggcttcacc ggtacttaca aaggccgcaa aatttccgta      180

atgggtcacg gtatgggtat cccgtcctgc tccatctaca ccaaagaact gatcaccgat      240

ttcggcgtga agaaaattat ccgcgtgggt tcctgtggcg cagttctgcc gcacgtaaaa      300

ctacgcgacg tcgttatcgg tatgggtgcc tgcaccgatt ccaaagttaa ccgcatccgt      360

tttaaagacc atgactttgc cgctatcgct gactttgaca tggtgcgtaa cgcggtagac      420

gcggctaaag cactgggcgt tgatgctcgc gtgggtaacc tgttctccgc tgacctgttc      480

tactctccgg acggcgaaat gttcgacgtg atggaaaaat acggcatcct cggcgtggaa      540

atggaagcgg ctggtatcta cggcgtcgct gcagaatttg gcgcgaaagc cctgaccatc      600

tgcaccgtgt ctgaccacat ccgcactcac gagcagacca ctgccgctga gcgtcagacc      660

accttcaacg acatgatcaa aatcgcactg gaatccgttc tgctgggcga taaagagtaa      720


<210> 78
<211> 413
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="NupC (polypeptide)"

<400> 78
Val His Gly Asn Leu Thr Cys Leu Ile Phe Gly Ala Asn Met Asp Arg 
1               5                   10                  15      


Val Leu His Phe Val Leu Ala Leu Ala Val Val Ala Ile Leu Ala Leu 
            20                  25                  30          


Leu Val Ser Ser Asp Arg Lys Lys Ile Arg Ile Arg Tyr Val Ile Gln 
        35                  40                  45              


Leu Leu Val Ile Glu Val Leu Leu Ala Trp Phe Phe Leu Asn Ser Asp 
    50                  55                  60                  


Val Gly Leu Gly Phe Val Lys Gly Phe Ser Glu Met Phe Glu Lys Leu 
65                  70                  75                  80  


Leu Gly Phe Ala Asn Glu Gly Thr Asn Phe Val Phe Gly Ser Met Asn 
                85                  90                  95      


Asp Gln Gly Leu Ala Phe Phe Phe Leu Lys Val Leu Cys Pro Ile Val 
            100                 105                 110         


Phe Ile Ser Ala Leu Ile Gly Ile Leu Gln His Ile Arg Val Leu Pro 
        115                 120                 125             


Val Ile Ile Arg Ala Ile Gly Phe Leu Leu Ser Lys Val Asn Gly Met 
    130                 135                 140                 


Gly Lys Leu Glu Ser Phe Asn Ala Val Ser Ser Leu Ile Leu Gly Gln 
145                 150                 155                 160 


Ser Glu Asn Phe Ile Ala Tyr Lys Asp Ile Leu Gly Lys Ile Ser Arg 
                165                 170                 175     


Asn Arg Met Tyr Thr Met Ala Ala Thr Ala Met Ser Thr Val Ser Met 
            180                 185                 190         


Ser Ile Val Gly Ala Tyr Met Thr Met Leu Glu Pro Lys Tyr Val Val 
        195                 200                 205             


Ala Ala Leu Val Leu Asn Met Phe Ser Thr Phe Ile Val Leu Ser Leu 
    210                 215                 220                 


Ile Asn Pro Tyr Arg Val Asp Ala Ser Glu Glu Asn Ile Gln Met Ser 
225                 230                 235                 240 


Asn Leu His Glu Gly Gln Ser Phe Phe Glu Met Leu Gly Glu Tyr Ile 
                245                 250                 255     


Leu Ala Gly Phe Lys Val Ala Ile Ile Val Ala Ala Met Leu Ile Gly 
            260                 265                 270         


Phe Ile Ala Leu Ile Ala Ala Leu Asn Ala Leu Phe Ala Thr Val Thr 
        275                 280                 285             


Gly Trp Phe Gly Tyr Ser Ile Ser Phe Gln Gly Ile Leu Gly Tyr Ile 
    290                 295                 300                 


Phe Tyr Pro Ile Ala Trp Val Met Gly Val Pro Ser Ser Glu Ala Leu 
305                 310                 315                 320 


Gln Val Gly Ser Ile Met Ala Thr Lys Leu Val Ser Asn Glu Phe Val 
                325                 330                 335     


Ala Met Met Asp Leu Gln Lys Ile Ala Ser Thr Leu Ser Pro Arg Ala 
            340                 345                 350         


Glu Gly Ile Ile Ser Val Phe Leu Val Ser Phe Ala Asn Phe Ser Ser 
        355                 360                 365             


Ile Gly Ile Ile Ala Gly Ala Val Lys Gly Leu Asn Glu Glu Gln Gly 
    370                 375                 380                 


Asn Val Val Ser Arg Phe Gly Leu Lys Leu Val Tyr Gly Ser Thr Leu 
385                 390                 395                 400 


Val Ser Val Leu Ser Ala Ser Ile Ala Ala Leu Val Leu 
                405                 410             


<210> 79
<211> 752
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="xdhA (polypeptide)"

<400> 79
Met Arg Val Asp Ala Ile Ala Lys Val Thr Gly Arg Ala Arg Tyr Thr 
1               5                   10                  15      


Asp Asp Tyr Ile Met Ala Gly Met Cys Tyr Ala Lys Tyr Val Arg Ser 
            20                  25                  30          


Pro Ile Ala His Gly Tyr Ala Val Asn Ile Asn Asp Glu Gln Ala Arg 
        35                  40                  45              


Ser Leu Pro Gly Val Leu Ala Ile Phe Thr Trp Glu Asp Val Pro Glu 
    50                  55                  60                  


Ile Pro Phe Ala Thr Ala Gly His Ala Trp Thr Leu Asp Glu Asn Lys 
65                  70                  75                  80  


Arg Asp Thr Ala Asp Arg Ala Leu Leu Thr Arg His Val Arg His His 
                85                  90                  95      


Gly Asp Ala Val Ala Ile Val Val Ala Arg Asp Glu Leu Thr Ala Glu 
            100                 105                 110         


Lys Ala Ala Gln Leu Val Ser Ile Glu Trp Gln Glu Leu Pro Val Ile 
        115                 120                 125             


Thr Ser Pro Glu Ala Ala Leu Ala Glu Asp Ala Ala Pro Ile His Asn 
    130                 135                 140                 


Gly Gly Asn Leu Leu Lys Gln Ser Thr Met Ser Thr Gly Asn Val Gln 
145                 150                 155                 160 


Gln Thr Ile Asp Ala Ala Asp Tyr Gln Val Gln Gly His Tyr Gln Thr 
                165                 170                 175     


Pro Val Ile Gln His Cys His Met Glu Ser Val Thr Ser Leu Ala Trp 
            180                 185                 190         


Met Glu Asp Asp Ser Arg Ile Thr Ile Val Ser Ser Thr Gln Ile Pro 
        195                 200                 205             


His Ile Val Arg Arg Val Val Gly Gln Ala Leu Asp Ile Pro Trp Ser 
    210                 215                 220                 


Cys Val Arg Val Ile Lys Pro Phe Ile Gly Gly Gly Phe Gly Asn Lys 
225                 230                 235                 240 


Gln Asp Val Leu Glu Glu Pro Met Ala Ala Phe Leu Thr Ser Lys Leu 
                245                 250                 255     


Gly Gly Ile Pro Val Lys Val Ser Leu Ser Arg Glu Glu Cys Phe Leu 
            260                 265                 270         


Ala Thr Arg Thr Arg His Ala Phe Thr Ile Asp Gly Gln Met Gly Val 
        275                 280                 285             


Asn Arg Asp Gly Thr Leu Lys Gly Tyr Ser Leu Asp Val Leu Ser Asn 
    290                 295                 300                 


Thr Gly Ala Tyr Ala Ser His Gly His Ser Ile Ala Ser Ala Gly Gly 
305                 310                 315                 320 


Asn Lys Val Ala Tyr Leu Tyr Pro Arg Cys Ala Tyr Ala Tyr Ser Ser 
                325                 330                 335     


Lys Thr Cys Tyr Thr Asn Leu Pro Ser Ala Gly Ala Met Arg Gly Tyr 
            340                 345                 350         


Gly Ala Pro Gln Val Val Phe Ala Val Glu Ser Met Leu Asp Asp Ala 
        355                 360                 365             


Ala Thr Ala Leu Gly Ile Asp Pro Val Glu Ile Arg Leu Arg Asn Ala 
    370                 375                 380                 


Ala Arg Glu Gly Asp Ala Asn Pro Leu Thr Gly Lys Arg Ile Tyr Ser 
385                 390                 395                 400 


Ala Gly Leu Pro Glu Cys Leu Glu Lys Gly Arg Lys Ile Phe Glu Trp 
                405                 410                 415     


Glu Lys Arg Arg Ala Glu Cys Gln Asn Gln Gln Gly Asn Leu Arg Arg 
            420                 425                 430         


Gly Val Gly Val Ala Cys Phe Ser Tyr Thr Ser Asn Thr Trp Pro Val 
        435                 440                 445             


Gly Val Glu Ile Ala Gly Ala Arg Leu Leu Met Asn Gln Asp Gly Thr 
    450                 455                 460                 


Ile Asn Val Gln Ser Gly Ala Thr Glu Ile Gly Gln Gly Ala Asp Thr 
465                 470                 475                 480 


Val Phe Ser Gln Met Val Ala Glu Thr Val Gly Val Pro Val Ser Asp 
                485                 490                 495     


Val His Val Ile Ser Thr Gln Asp Thr Asp Val Thr Pro Phe Asp Pro 
            500                 505                 510         


Gly Ala Phe Ala Ser Arg Gln Ser Tyr Val Ala Ala Pro Ala Leu Arg 
        515                 520                 525             


Ser Ala Ala Leu Leu Leu Lys Glu Lys Ile Ile Ala His Ala Ala Val 
    530                 535                 540                 


Met Leu His Gln Ser Ala Met Asn Leu Thr Leu Ile Lys Gly His Ile 
545                 550                 555                 560 


Val Leu Ile Glu Arg Pro Glu Glu Pro Leu Met Ser Leu Lys Asp Leu 
                565                 570                 575     


Ala Met Asp Ala Phe Tyr His Pro Glu Arg Gly Gly Gln Leu Ser Ala 
            580                 585                 590         


Glu Ser Ser Ile Lys Thr Thr Thr Asn Pro Pro Ala Phe Gly Cys Thr 
        595                 600                 605             


Phe Val Asp Leu Thr Val Asp Ile Ala Leu Cys Lys Val Thr Ile Asn 
    610                 615                 620                 


Arg Ile Leu Asn Val His Asp Ser Gly His Ile Leu Asn Pro Leu Leu 
625                 630                 635                 640 


Ala Glu Gly Gln Val His Gly Gly Met Gly Met Gly Ile Gly Trp Ala 
                645                 650                 655     


Leu Phe Glu Glu Met Ile Ile Asp Ala Lys Ser Gly Val Val Arg Asn 
            660                 665                 670         


Pro Asn Leu Leu Asp Tyr Lys Met Pro Thr Met Pro Asp Leu Pro Gln 
        675                 680                 685             


Leu Glu Ser Ala Phe Val Glu Ile Asn Glu Pro Gln Ser Ala Tyr Gly 
    690                 695                 700                 


His Lys Ser Leu Gly Glu Pro Pro Ile Ile Pro Val Ala Ala Ala Ile 
705                 710                 715                 720 


Arg Asn Ala Val Lys Met Ala Thr Gly Val Ala Ile Asn Thr Leu Pro 
                725                 730                 735     


Leu Thr Pro Lys Arg Leu Tyr Glu Glu Phe His Leu Ala Gly Leu Ile 
            740                 745                 750         


<210> 80
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="xdhB (polypeptide)"

<400> 80
Met Phe Asp Phe Ala Ser Tyr His Arg Ala Thr Thr Leu Ala Asp Ala 
1               5                   10                  15      


Ile Thr Leu Leu Ala Asp Asn Pro Gln Ala Lys Leu Leu Ala Gly Gly 
            20                  25                  30          


Thr Asp Val Leu Ile Gln Leu His His His Asn Asp Arg Tyr Arg His 
        35                  40                  45              


Ile Val Asp Ile His Asn Leu Ala Glu Leu Gln Gly Ile Thr Gln Ala 
    50                  55                  60                  


Glu Asp Gly Ala Leu Arg Ile Gly Ser Ala Thr Thr Phe Thr Gln Leu 
65                  70                  75                  80  


Ile Glu Asp Pro Val Ile Gln Arg Asn Leu Pro Ala Leu Cys Ala Ala 
                85                  90                  95      


Ala Ala Ser Ile Ala Gly Pro Gln Ile Arg Asn Val Ala Thr Tyr Gly 
            100                 105                 110         


Gly Asn Ile Cys Asn Gly Ala Thr Ser Ala Asp Ser Ala Thr Pro Thr 
        115                 120                 125             


Leu Ile Tyr Asp Ala Lys Leu Glu Leu His Ser Pro Arg Gly Val Arg 
    130                 135                 140                 


Phe Val Pro Ile Asn Gly Phe His Thr Gly Pro Gly Lys Val Ser Leu 
145                 150                 155                 160 


Glu His Asp Glu Ile Leu Val Ala Phe His Phe Pro Pro Gln Pro Lys 
                165                 170                 175     


Glu His Ala Gly Ser Ala His Phe Lys Tyr Ala Met Arg Asp Ala Met 
            180                 185                 190         


Asp Ile Ser Thr Ile Gly Cys Ala Ala His Cys Arg Leu Asp Asn Gly 
        195                 200                 205             


Asn Phe Ser Glu Leu Arg Leu Ala Phe Gly Val Ala Ala Pro Thr Pro 
    210                 215                 220                 


Ile Arg Cys Gln His Ala Glu Gln Thr Ala Gln Asn Ala Pro Leu Asn 
225                 230                 235                 240 


Leu Gln Thr Leu Glu Ala Ile Ser Glu Ser Val Leu Gln Asp Val Ala 
                245                 250                 255     


Pro Arg Ser Ser Trp Arg Ala Ser Lys Glu Phe Arg Leu His Leu Ile 
            260                 265                 270         


Gln Thr Met Thr Lys Lys Val Ile Ser Glu Ala Val Ala Ala Ala Gly 
        275                 280                 285             


Gly Lys Leu Gln 
    290         


<210> 81
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="xdhC (polypeptide)"

<400> 81
Met Phe Asp Phe Ala Ser Tyr His Arg Ala Thr Thr Leu Ala Asp Ala 
1               5                   10                  15      


Ile Thr Leu Leu Ala Asp Asn Pro Gln Ala Lys Leu Leu Ala Gly Gly 
            20                  25                  30          


Thr Asp Val Leu Ile Gln Leu His His His Asn Asp Arg Tyr Arg His 
        35                  40                  45              


Ile Val Asp Ile His Asn Leu Ala Glu Leu Gln Gly Ile Thr Gln Ala 
    50                  55                  60                  


Glu Asp Gly Ala Leu Arg Ile Gly Ser Ala Thr Thr Phe Thr Gln Leu 
65                  70                  75                  80  


Ile Glu Asp Pro Val Ile Gln Arg Asn Leu Pro Ala Leu Cys Ala Ala 
                85                  90                  95      


Ala Ala Ser Ile Ala Gly Pro Gln Ile Arg Asn Val Ala Thr Tyr Gly 
            100                 105                 110         


Gly Asn Ile Cys Asn Gly Ala Thr Ser Ala Asp Ser Ala Thr Pro Thr 
        115                 120                 125             


Leu Ile Tyr Asp Ala Lys Leu Glu Leu His Ser Pro Arg Gly Val Arg 
    130                 135                 140                 


Phe Val Pro Ile Asn Gly Phe His Thr Gly Pro Gly Lys Val Ser Leu 
145                 150                 155                 160 


Glu His Asp Glu Ile Leu Val Ala Phe His Phe Pro Pro Gln Pro Lys 
                165                 170                 175     


Glu His Ala Gly Ser Ala His Phe Lys Tyr Ala Met Arg Asp Ala Met 
            180                 185                 190         


Asp Ile Ser Thr Ile Gly Cys Ala Ala His Cys Arg Leu Asp Asn Gly 
        195                 200                 205             


Asn Phe Ser Glu Leu Arg Leu Ala Phe Gly Val Ala Ala Pro Thr Pro 
    210                 215                 220                 


Ile Arg Cys Gln His Ala Glu Gln Thr Ala Gln Asn Ala Pro Leu Asn 
225                 230                 235                 240 


Leu Gln Thr Leu Glu Ala Ile Ser Glu Ser Val Leu Gln Asp Val Ala 
                245                 250                 255     


Pro Arg Ser Ser Trp Arg Ala Ser Lys Glu Phe Arg Leu His Leu Ile 
            260                 265                 270         


Gln Thr Met Thr Lys Lys Val Ile Ser Glu Ala Val Ala Ala Ala Gly 
        275                 280                 285             


Gly Lys Leu Gln 
    290         


<210> 82
<211> 333
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Add (polypeptide)"

<400> 82
Met Ile Asp Thr Thr Leu Pro Leu Thr Asp Ile His Arg His Leu Asp 
1               5                   10                  15      


Gly Asn Ile Arg Pro Gln Thr Ile Leu Glu Leu Gly Arg Gln Tyr Asn 
            20                  25                  30          


Ile Ser Leu Pro Ala Gln Ser Leu Glu Thr Leu Ile Pro His Val Gln 
        35                  40                  45              


Val Ile Ala Asn Glu Pro Asp Leu Val Ser Phe Leu Thr Lys Leu Asp 
    50                  55                  60                  


Trp Gly Val Lys Val Leu Ala Ser Leu Asp Ala Cys Arg Arg Val Ala 
65                  70                  75                  80  


Phe Glu Asn Ile Glu Asp Ala Ala Arg Asn Gly Leu His Tyr Val Glu 
                85                  90                  95      


Leu Arg Phe Ser Pro Gly Tyr Met Ala Met Ala His Gln Leu Pro Val 
            100                 105                 110         


Ala Gly Val Val Glu Ala Val Ile Asp Gly Val Arg Glu Gly Cys Arg 
        115                 120                 125             


Thr Phe Gly Val Gln Ala Lys Leu Ile Gly Ile Met Ser Arg Thr Phe 
    130                 135                 140                 


Gly Glu Ala Ala Cys Gln Gln Glu Leu Glu Ala Phe Leu Ala His Arg 
145                 150                 155                 160 


Asp Gln Ile Thr Ala Leu Asp Leu Ala Gly Asp Glu Leu Gly Phe Pro 
                165                 170                 175     


Gly Ser Leu Phe Leu Ser His Phe Asn Arg Ala Arg Asp Ala Gly Trp 
            180                 185                 190         


His Ile Thr Val His Ala Gly Glu Ala Ala Gly Pro Glu Ser Ile Trp 
        195                 200                 205             


Gln Ala Ile Arg Glu Leu Gly Ala Glu Arg Ile Gly His Gly Val Lys 
    210                 215                 220                 


Ala Ile Glu Asp Arg Ala Leu Met Asp Phe Leu Ala Glu Gln Gln Ile 
225                 230                 235                 240 


Gly Ile Glu Ser Cys Leu Thr Ser Asn Ile Gln Thr Ser Thr Val Ala 
                245                 250                 255     


Asp Leu Ala Ala His Pro Leu Lys Thr Phe Leu Glu His Gly Ile Arg 
            260                 265                 270         


Ala Ser Ile Asn Thr Asp Asp Pro Gly Val Gln Gly Val Asp Ile Ile 
        275                 280                 285             


His Glu Tyr Thr Val Ala Ala Pro Ala Ala Gly Leu Ser Arg Glu Gln 
    290                 295                 300                 


Ile Arg Gln Ala Gln Ile Asn Gly Leu Glu Met Ala Phe Leu Ser Ala 
305                 310                 315                 320 


Glu Glu Lys Arg Ala Leu Arg Glu Lys Val Ala Ala Lys 
                325                 330             


<210> 83
<211> 277
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="xapA (polypeptide)"

<400> 83
Met Tyr Gln Ala Gln Phe Ser His Asn Pro Leu Tyr Cys Val Asp Ile 
1               5                   10                  15      


Ile Lys Thr Tyr Lys Pro Asp Phe Thr Pro Arg Val Ala Phe Ile Leu 
            20                  25                  30          


Gly Ser Gly Leu Gly Ala Leu Ala Asp Gln Ile Glu Asn Ala Val Ala 
        35                  40                  45              


Ile Ser Tyr Glu Lys Leu Pro Gly Phe Pro Val Ser Thr Val His Gly 
    50                  55                  60                  


His Ala Gly Glu Leu Val Leu Gly Tyr Leu Gln Gly Val Pro Val Ala 
65                  70                  75                  80  


Cys Met Lys Gly Arg Gly His Phe Tyr Glu Gly Arg Gly Met Thr Ile 
                85                  90                  95      


Met Thr Asp Ala Ile Arg Thr Phe Lys Leu Leu Gly Cys Glu Leu Leu 
            100                 105                 110         


Phe Cys Thr Asn Ala Ala Gly Ser Leu Arg Pro Glu Val Gly Ala Gly 
        115                 120                 125             


Ser Leu Val Ala Leu Lys Asp His Ile Asn Thr Met Pro Gly Thr Pro 
    130                 135                 140                 


Met Val Gly Leu Asn Asp Glu Arg Phe Gly Glu Arg Phe Phe Ser Leu 
145                 150                 155                 160 


Ala Asn Ala Tyr Asp Ala Glu Tyr Arg Ala Leu Leu Gln Lys Val Ala 
                165                 170                 175     


Lys Glu Glu Gly Phe Pro Leu Thr Glu Gly Val Phe Val Ser Tyr Pro 
            180                 185                 190         


Gly Pro Asn Phe Glu Thr Ala Ala Glu Ile Arg Met Met Gln Ile Ile 
        195                 200                 205             


Gly Gly Asp Val Val Gly Met Ser Val Val Pro Glu Val Ile Ser Ala 
    210                 215                 220                 


Arg His Cys Glu Leu Lys Val Val Ala Val Ser Ala Ile Thr Asn Met 
225                 230                 235                 240 


Ala Glu Gly Leu Ser Asp Val Lys Leu Ser His Ala Gln Thr Leu Ala 
                245                 250                 255     


Ala Ala Glu Leu Ser Lys Gln Asn Phe Ile Asn Leu Ile Cys Gly Phe 
            260                 265                 270         


Leu Arg Lys Ile Ala 
        275         


<210> 84
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="deoD (polypeptide)"

<400> 84
Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210> 85
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="argA WT"

<400> 85
gcaaaaaaac agaataaaaa tacaataatt tcgaataatc atgcaaagag gtgtaccgtg       60


<210> 86
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="argA mutant"

<400> 86
gcaaaaaaac actttaaaaa cttaataatt tcctttaatc acttaaagag gtgtaccgtg       60


<210> 87
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="argI WT"

<400> 87
agacttgcaa atgaataatc atccatatag attgaatttt aattcattaa ggcgttagcc       60

acaggaggga tctatg                                                       76


<210> 88
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="argI mutant"

<400> 88
agacttgcaa acttatactt atccatatag attttgtttt aatttgttaa ggcgttagcc       60

acaggaggga tctatg                                                       76


<210> 89
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="argCBH WT"

<400> 89
tcattgttga cacacctctg gtcatgatag tatcaatatt catgcagtat ttatgaataa       60

aaatacacta acgttgagcg taataaaacc caccagccgt aaggtgaatg ttttacgttt      120

aacctggcaa ccagacataa gaaggtgaat agccccgatg                            160


<210> 90
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="argCBH mutant"

<400> 90
tcattgttga cacacctctg gtcatgatag tatcaaactt catgggatat ttatctttaa       60

aaatacttga acgttgagcg taataaaacc caccagccgt aaggtgaatg ttttacgttt      120

aacctggcaa ccagacataa gaaggtgaat agccccgatg                            160


<210> 91
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="argE WT"

<400> 91
catcggggct attcaccttc ttatgtctgg ttgccaggtt aaacgtaaaa cattcacctt       60

acggctggtg ggttttatta cgctcaacgt tagtgtattt ttattcataa atactgcatg      120

aatattgata ctatcatgac cagaggtgtg tcaacaatga                            160


<210> 92
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="argE mutant"

<400> 92
catcggggct attcaccttc ttatgtctgg ttgccaggtt aaacgtaaaa cattcacctt       60

acggctggtg ggttttatta cgctcaacgt tcaagtattt ttaaagataa atatcccatg      120

aagtttgata ctatcatgac cagaggtgtg tcaacaatga                            160


<210> 93
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="carAB WT"

<400> 93
agcagatttg cattgattta cgtcatcatt gtgaattaat atgcaaataa agtgagtgaa       60

tattctctgg agggtgtttt g                                                 81


<210> 94
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="carAB mutant"

<400> 94
agcagatttg cattgattta cgtcatcatt gtcttttaat atcttaataa ctggagtgac       60

gtttctctgg agggtgtttt g                                                 81


<210> 95
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="argD WT"

<400> 95
tttctgattg ccattcagtg attttttatg catattttgt gattataatt tcatatttat       60

ttatgcgtaa cagggtgatc atgagatg                                          88


<210> 96
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="argD mutant"

<400> 96
tttctgattg ccattcagtc tttttttact tatattttgt ctttataatc ttatatttat       60

ttatgcgtaa cagggtgatc atgagatg                                          88


<210> 97
<211> 219
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="argG WT"

<400> 97
ctaatcacgt gaatgaatat ccagttcact ttcatttgtt gaatactttt accttctcct       60

gctttccctt aagcgcatta ttttacaaaa aacacactaa actcttcctg tctccgataa      120

aagatgatta aatgaaaact catttatttt gcataaaaat tcagtgaaag cagaaatcca      180

ggctcatcat cagttaatta agcagggtgt tattttatg                             219


<210> 98
<211> 219
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="argG mutant"

<400> 98
ctaatcacct taatgaatct tcagttcact ttcatttgtt gaatactttt accttctcct       60

gctttccctt aagcgcatta ttttacaaaa aacacactaa actcttcctg tctccgataa      120

aagatgatct tatgaaaacc tttttatttc ttataaaaat cttgtgaaag cagaaatcca      180

ggctcatcat cagttaatta agcagggtgt tattttatg                             219


<210> 99
<211> 233
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="argG mutant"

<400> 99
cctgaaacgt ggcaaattct actcgttttg ggtaaaaaat gcaaatactg ctgggatttg       60

gtgtaccgag acgggacgta aaatctgcag gcattatagt gatccacgcc acattttgtc      120

aacgtttatt gctaatcatt gacggctagc tcagtcctag gtacagtgct agcacccgtt      180

tttttgggct agaaataatt ttgtttaact ttaagaagga gatatacata ccc             233


<210> 100
<211> 1053
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Wild-type argG"

<400> 100
gtgatccacg ccacattttg tcaacgttta ttgctaatca cgtgaatgaa tatccagttc       60

actttcattt gttgaatact tttaccttct cctgctttcc cttaagcgca ttattttaca      120

aaaaacacac taaactcttc ctgtctccga taaaagatga ttaaatgaaa actcatttat      180

tttgcataaa aattcagtga aagcagaaat ccaggctcat catcagttaa ttaagcaggg      240

tgttatttta tgacgacgat tctcaagcat ctcccggtag gtcaacgtat tggtatcgct      300

ttttccggcg gtctggacac cagtgccgca ctgctgtgga tgcgacaaaa gggagcggtt      360

ccttatgcat atactgcaaa cctgggccag ccagacgaag aggattatga tgcgatccct      420

cgtcgtgcca tggaatacgg cgcggagaac gcacgtctga tcgactgccg caaacaactg      480

gtggccgaag gtattgccgc tattcagtgt ggcgcatttc ataacaccac tggtggactg      540

acctatttca acacgacgcc gctgggccgc gccgtgaccg gcaccatgct ggttgctgct      600

atgaaagaag atggcgtgaa tatctggggt gacggcagca cctataaagg aaacgatatc      660

gaacgtttct accgttacgg tctgctgacc aatgctgaac tgcagattta caaaccgtgg      720

cttgatactg actttattga tgaactgggt ggccgtcatg agatgtctga atttatgatt      780

gcctgcggtt tcgactacaa aatgtctgtc gaaaaagctt actccacgga ctccaacatg      840

cttggtgcaa cgcatgaagc gaaggatctg gaatacctca actccagcgt caaaatcgtc      900

aacccaatta tgggcgtgaa gttttgggat gagagcgtga aaatcccggc agaagaagtc      960

acagtacgct ttgagcaagg tcatccggtg gcgctgaacg gtaaaacctt tagcgacgac     1020

gtagaaatga tgctggaagc taaccgcatc ggc                                  1053


<210> 101
<211> 734
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Constitutive argG"

<400> 101
ttgacggcta gctcagtcct aggtacagtg ctagcacccg tttttttggg ctagaaataa       60

ttttgtttaa ctttaagaag gagatataca tacccatgac gacgattctc aagcatctcc      120

cggtaggtca acgtattggt atcgcttttt ccggcggtct ggacaccagt gccgcactgc      180

tgtggatgcg acaaaaggga gcggttcctt atgcatatac tgcaaacctg ggccagccag      240

acgaagagga ttatgatgcg atccctcgtc gtgccatgga atacggcgcg gagaacgcac      300

gtctgatcga ctgccgcaaa caactggtgg ccgaaggtat tgccgctatt cagtgtggcg      360

catttcataa caccactggt ggactgacct atttcaacac gacgccgctg ggccgcgccg      420

tgaccggcac catgctggtt gctgctatga aagaagatgg cgtgaatatc tggggtgacg      480

gcagcaccta taaaggaaac gatatcgaac gtttctaccg ttacggtctg ctgaccaatg      540

ctgaactgca gatttacaaa ccgtggcttg atactgactt tattgatgaa ctgggtggcc      600

gtcatgagat gtctgaattt atgattgcct gcggtttcga ctacaaaatg tctgtcgaaa      660

aagcttactc cacggactcc aacatgcttg gtgcaacgca tgaagcgaag gatctggaat      720

acctcaactc cagc                                                        734


<210> 102
<211> 1332
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Nucleotide sequence of exemplary argAfbr sequence"

<400> 102
atggtaaagg aacgtaaaac cgagttggtc gagggattcc gccattcggt tccctgtatc       60

aatacccacc ggggaaaaac gtttgtcatc atgctcggcg gtgaagccat tgagcatgag      120

aatttctcca gtatcgttaa tgatatcggg ttgttgcaca gcctcggcat ccgtctggtg      180

gtggtctatg gcgcacgtcc gcagatcgac gcaaatctgg ctgcgcatca ccacgaaccg      240

ctgtatcaca agaatatacg tgtgaccgac gccaaaacac tggaactggt gaagcaggct      300

gcgggaacat tgcaactgga tattactgct cgcctgtcga tgagtctcaa taacacgccg      360

ctgcagggcg cgcatatcaa cgtcgtcagt ggcaatttta ttattgccca gccgctgggc      420

gtcgatgacg gcgtggatta ctgccatagc gggcgtatcc ggcggattga tgaagacgcg      480

atccatcgtc aactggacag cggtgcaata gtgctaatgg ggccggtcgc tgtttcagtc      540

actggcgaga gctttaacct gacctcggaa gagattgcca ctcaactggc catcaaactg      600

aaagctgaaa agatgattgg tttttgctct tcccagggcg tcactaatga cgacggtgat      660

attgtctccg aacttttccc taacgaagcg caagcgcggg tagaagccca ggaagagaaa      720

ggcgattaca actccggtac ggtgcgcttt ttgcgtggcg cagtgaaagc ctgccgcagc      780

ggcgtgcgtc gctgtcattt aatcagttat caggaagatg gcgcgctgtt gcaagagttg      840

ttctcacgcg acggtatcgg tacgcagatt gtgatggaaa gcgccgagca gattcgtcgc      900

gcaacaatca acgatattgg cggtattctg gagttgattc gcccactgga gcagcaaggt      960

attctggtac gccgttctcg cgagcagctg gagatggaaa tcgacaaatt caccattatt     1020

cagcgcgata acacgactat tgcctgcgcc gcgctctatc cgttcccgga agagaagatt     1080

ggggaaatgg cctgtgtggc agttcacccg gattaccgca gttcatcaag gggtgaagtt     1140

ctgctggaac gcattgccgc tcaggctaag cagagcggct taagcaaatt gtttgtgctg     1200

accacgcgca gtattcactg gttccaggaa cgtggattta ccccagtgga tattgattta     1260

ctgcccgaga gcaaaaagca gttgtacaac taccagcgta aatccaaagt gttgatggcg     1320

gatttagggt aa                                                         1332


<210> 103
<211> 443
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Polypeptide sequence of exemplary argAfbr sequence"

<400> 103
Met Val Lys Glu Arg Lys Thr Glu Leu Val Glu Gly Phe Arg His Ser 
1               5                   10                  15      


Val Pro Cys Ile Asn Thr His Arg Gly Lys Thr Phe Val Ile Met Leu 
            20                  25                  30          


Gly Gly Glu Ala Ile Glu His Glu Asn Phe Ser Ser Ile Val Asn Asp 
        35                  40                  45              


Ile Gly Leu Leu His Ser Leu Gly Ile Arg Leu Val Val Val Tyr Gly 
    50                  55                  60                  


Ala Arg Pro Gln Ile Asp Ala Asn Leu Ala Ala His His His Glu Pro 
65                  70                  75                  80  


Leu Tyr His Lys Asn Ile Arg Val Thr Asp Ala Lys Thr Leu Glu Leu 
                85                  90                  95      


Val Lys Gln Ala Ala Gly Thr Leu Gln Leu Asp Ile Thr Ala Arg Leu 
            100                 105                 110         


Ser Met Ser Leu Asn Asn Thr Pro Leu Gln Gly Ala His Ile Asn Val 
        115                 120                 125             


Val Ser Gly Asn Phe Ile Ile Ala Gln Pro Leu Gly Val Asp Asp Gly 
    130                 135                 140                 


Val Asp Tyr Cys His Ser Gly Arg Ile Arg Arg Ile Asp Glu Asp Ala 
145                 150                 155                 160 


Ile His Arg Gln Leu Asp Ser Gly Ala Ile Val Leu Met Gly Pro Val 
                165                 170                 175     


Ala Val Ser Val Thr Gly Glu Ser Phe Asn Leu Thr Ser Glu Glu Ile 
            180                 185                 190         


Ala Thr Gln Leu Ala Ile Lys Leu Lys Ala Glu Lys Met Ile Gly Phe 
        195                 200                 205             


Cys Ser Ser Gln Gly Val Thr Asn Asp Asp Gly Asp Ile Val Ser Glu 
    210                 215                 220                 


Leu Phe Pro Asn Glu Ala Gln Ala Arg Val Glu Ala Gln Glu Glu Lys 
225                 230                 235                 240 


Gly Asp Tyr Asn Ser Gly Thr Val Arg Phe Leu Arg Gly Ala Val Lys 
                245                 250                 255     


Ala Cys Arg Ser Gly Val Arg Arg Cys His Leu Ile Ser Tyr Gln Glu 
            260                 265                 270         


Asp Gly Ala Leu Leu Gln Glu Leu Phe Ser Arg Asp Gly Ile Gly Thr 
        275                 280                 285             


Gln Ile Val Met Glu Ser Ala Glu Gln Ile Arg Arg Ala Thr Ile Asn 
    290                 295                 300                 


Asp Ile Gly Gly Ile Leu Glu Leu Ile Arg Pro Leu Glu Gln Gln Gly 
305                 310                 315                 320 


Ile Leu Val Arg Arg Ser Arg Glu Gln Leu Glu Met Glu Ile Asp Lys 
                325                 330                 335     


Phe Thr Ile Ile Gln Arg Asp Asn Thr Thr Ile Ala Cys Ala Ala Leu 
            340                 345                 350         


Tyr Pro Phe Pro Glu Glu Lys Ile Gly Glu Met Ala Cys Val Ala Val 
        355                 360                 365             


His Pro Asp Tyr Arg Ser Ser Ser Arg Gly Glu Val Leu Leu Glu Arg 
    370                 375                 380                 


Ile Ala Ala Gln Ala Lys Gln Ser Gly Leu Ser Lys Leu Phe Val Leu 
385                 390                 395                 400 


Thr Thr Arg Ser Ile His Trp Phe Gln Glu Arg Gly Phe Thr Pro Val 
                405                 410                 415     


Asp Ile Asp Leu Leu Pro Glu Ser Lys Lys Gln Leu Tyr Asn Tyr Gln 
            420                 425                 430         


Arg Lys Ser Lys Val Leu Met Ala Asp Leu Gly 
        435                 440             


<210> 104
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="melittin"

<400> 104
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Lys Gln Gln 
            20                  25      


<210> 105
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="LL-37"

<400> 105
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210> 106
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="cecropin B"

<400> 106
Lys Trp Lys Val Phe Lys Lys Ile Glu Lys Met Gly Arg Asn Ile Arg 
1               5                   10                  15      


Asn Gly Ile Val Lys Ala Gly Pro Ala Ile Ala Val Leu Gly Glu Ala 
            20                  25                  30          


Lys Ala Leu 
        35  


<210> 107
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Magainin 2"

<400> 107
Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Glu Ile Met Asn Ser 
            20                  


<210> 108
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="EZH2"

<400> 108
Phe Ile Asn Asp Glu Ile Phe Val Glu Leu 
1               5                   10  


<210> 109
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="EZH2"

<400> 109
Lys Tyr Asp Cys Phe Leu His Pro Phe 
1               5                   


<210> 110
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="EZH2"

<400> 110
Lys Tyr Val Gly Ile Glu Arg Glu Met 
1               5                   


<210> 111
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="glypican-3"

<400> 111
Glu Tyr Ile Leu Ser Leu Glu Glu Leu 
1               5                   


<210> 112
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="consensus sequence"

<400> 112
ttgttgayry rtcaacwa                                                     18


<210> 113
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="consensus sequence"


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, g or t

<400> 113
ttataatnat tataa                                                        15


<210> 114
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="LacO"

<400> 114
ggaattgtga gcgctcacaa tt                                                22


<210> 115
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="UP element helps recruit RNA polymerase"

<400> 115
ggaaaatttt tttaaaaaaa aaac                                              24


<210> 116
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RBS"

<400> 116
ttatataaaa gtgggaggtg cccga                                             25


<210> 117
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 117
Lys Val Leu Glu Tyr Val Ile Lys Val 
1               5                   


<210> 118
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Melan-A / MART-1"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(10)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 118
Glu Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210> 119
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Melan-A / MART-1"

<400> 119
Ile Leu Thr Val Ile Leu Gly Val Leu 
1               5                   


<210> 120
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Melan-A / MART-1"


<220>
<221> VARIANT
<222> (11)..(11) 
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(11)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 120
Ala Glu Glu Ala Ala Gly Ile Gly Ile Leu Thr 
1               5                   10      


<210> 121
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Melan-A / MART-1"

<400> 121
Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser 
1               5                   10      


<210> 122
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Melan-A / MART-1"

<400> 122
Glu Glu Ala Ala Gly Ile Gly Ile Leu Thr Val Ile 
1               5                   10          


<210> 123
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="SR34"

<400> 123
cgcacactgg cgtcggctct ggcaggatgt ttcgtaatta gatagc                      46


<210> 124
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Bevacizumab (Avastin) anti-VEGF, Heavy Chain"

<400> 124
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210> 125
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Bevacizumab (Avastin) anti-VEGF, Light Chain"

<400> 125
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 126
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="D-peptide A"

<400> 126
Arg Leu Tyr Leu Arg Ile Gly Arg Arg 
1               5                   


<210> 127
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="D-peptide B"

<400> 127
Arg Leu Arg Leu Arg Ile Gly Arg Arg 
1               5                   


<210> 128
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="D-peptide C"

<400> 128
Ala Leu Tyr Leu Ala Ile Arg Arg Arg 
1               5                   


<210> 129
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="D-peptide D"

<400> 129
Arg Leu Leu Leu Arg Ile Gly Arg Arg 
1               5                   


<210> 130
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="D-K6L9"

<400> 130
Leu Lys Leu Leu Lys Lys Leu Leu Lys Lys Leu Leu Lys Leu Leu 
1               5                   10                  15  


<210> 131
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NRC-03"

<400> 131
Gly Arg Arg Lys Arg Lys Trp Leu Arg Arg Ile Gly Lys Gly Val Lys 
1               5                   10                  15      


Ile Ile Gly Gly Ala Ala Leu Asp His Leu 
            20                  25      


<210> 132
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NRC-07"

<400> 132
Arg Trp Gly Lys Trp Phe Lys Lys Ala Thr His Val Gly Lys His Val 
1               5                   10                  15      


Gly Lys Ala Ala Leu Thr Ala Tyr Leu 
            20                  25  


<210> 133
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Gomesin"

<400> 133
Glx Cys Arg Arg Leu Cys Tyr Lys Gln Arg Cys Val Thr Tyr Cys Arg 
1               5                   10                  15      


Gly Arg 
        


<210> 134
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Hepcidin TH2-3"

<400> 134
Gln Ser His Leu Ser Leu Cys Arg Trp Cys Cys Asn Cys Cys Arg Ser 
1               5                   10                  15      


Asn Lys Gly Cys 
            20  


<210> 135
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Dermaseptin B2"

<400> 135
Gly Leu Trp Ser Lys Ile Lys Glu Val Gly Lys Glu Ala Ala Lys Ala 
1               5                   10                  15      


Ala Ala Lys Ala Ala Gly Lys Ala Ala Leu Gly Ala Val Ser Glu Ala 
            20                  25                  30          


Val 
    


<210> 136
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PTP7"

<400> 136
Phe Leu Gly Ala Leu Phe Lys Ala Leu Ser Lys Leu Leu 
1               5                   10              


<210> 137
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="MGA2"

<400> 137
Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Ile Met Asn Ser Gly Gly Lys Lys Trp Lys Met Arg Arg 
            20                  25                  30          


Asn Gln Phe Trp Val Lys Val Gln Arg Gly 
        35                  40          


<210> 138
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="HNP-1"

<400> 138
Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210> 139
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Tachyplesin"

<400> 139
Lys Trp Cys Phe Arg Val Cys Tyr Arg Gly Ile Cys Tyr Arg Arg Cys 
1               5                   10                  15      


Arg 
    


<210> 140
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Temporin-1CEa"

<400> 140
Phe Val Asp Leu Lys Lys Ile Ala Asn Ile Ile Asn Ser Ile Phe 
1               5                   10                  15  


<210> 141
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NK-2"

<400> 141
Lys Ile Leu Arg Gly Val Cys Lys Lys Ile Met Arg Thr Phe Leu Arg 
1               5                   10                  15      


Arg Ile Ser Lys Asp Ile Leu Thr Gly Lys Lys 
            20                  25          


<210> 142
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Bovine lactoferricin B6 (Lbcin B6)"

<400> 142
Arg Arg Trp Gln Trp Arg 
1               5       


<210> 143
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Cecropin CB1"

<400> 143
Lys Trp Lys Val Phe Lys Lys Ile Glu Lys Met Gly Arg Asn Ile Arg 
1               5                   10                  15      


Asn Gly Ile Val Lys Ala Gly Pro Lys Trp Lys Val Phe Lys Lys Ile 
            20                  25                  30          


Glu Lys 
        


<210> 144
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Melittin"

<400> 144
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210> 145
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Tachyplesin"

<400> 145
Lys Trp Cys Phe Arg Val Cys Tyr Arg Gly Ile Cys Tyr Arg Arg Cys 
1               5                   10                  15      


Arg 
    


<210> 146
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="LL-37"

<400> 146
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210> 147
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Cecropin B"

<400> 147
Lys Trp Lys Val Phe Lys Lys Ile Glu Lys Met Gly Arg Asn Ile Arg 
1               5                   10                  15      


Asn Gly Ile Val Lys Ala Gly Pro Ala Ile Ala Val Leu Gly Glu Ala 
            20                  25                  30          


Lys Ala Leu 
        35  


<210> 148
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Magainin 2"

<400> 148
Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Ile Met Asn Ser 
            20              


<210> 149
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Buforin IIb"

<400> 149
Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Leu Leu Arg Arg Leu Leu 
1               5                   10                  15      


Arg Arg Leu Leu Arg 
            20      


<210> 150
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Alloferon-1"

<400> 150
His Gly Val Ser Gly His Gly Gln His Gly Val His Gly 
1               5                   10              


<210> 151
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Alloferon-2"

<400> 151
Gly Val Ser Gly His Gly Gln His Gly Val His Gly 
1               5                   10          


<210> 152
<211> 253
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="interleukin-12 subunit alpha precursor (homo sapiens)"

<400> 152
Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210> 153
<211> 328
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="interleukin-12 subunit beta precursor (homo sapiens)"

<400> 153
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210> 154
<211> 162
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="interleukin-15 isoform1 preproprotein (homo sapiens)"

<400> 154
Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210> 155
<211> 135
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="interleukin-15 isoform 2 preproprotein (homo sapiens)"

<400> 155
Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 
1               5                   10                  15      


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser 
    130                 135 


<210> 156
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="interleukin-2 precursor (homo sapiens)"

<400> 156
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210> 157
<211> 162
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="interleukin-21 isoform 1 precursor (homo sapiens)"

<400> 157
Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser 
        


<210> 158
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="interleukin-21 isoform 2 precursor (homo sapiens)"

<400> 158
Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Val Ser Thr Leu Ser Phe Ile 
145                 150             


<210> 159
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="granulocyte-macrophage colony-stimulating factor
      precursor (homo sapiens)"

<400> 159
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 160
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="alpha-actinin-4"

<400> 160
Phe Ile Ala Ser Asn Gly Val Lys Leu Val 
1               5                   10  


<210> 161
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="ARTC1"

<400> 161
Tyr Ser Val Tyr Phe Asn Leu Pro Ala Asp Thr Ile Tyr Thr Asn His 
1               5                   10                  15      


<210> 162
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="BCR-ABL fusion protein (b3a2)"

<400> 162
Ser Ser Lys Ala Leu Gln Arg Pro Val 
1               5                   


<210> 163
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="BCR-ABL fusion protein (b3a2)"

<400> 163
Gly Phe Lys Gln Ser Ser Lys Ala Leu 
1               5                   


<210> 164
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="BCR-ABL fusion protein (b3a2)"

<400> 164
Ala Thr Gly Phe Lys Gln Ser Ser Lys Ala Leu Gln Arg Pro Val Ala 
1               5                   10                  15      


Ser 
    


<210> 165
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="B-RAF"

<400> 165
Glu Asp Leu Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Glu Lys 
1               5                   10                  15      


Ser Arg Trp Ser Gly Ser His Gln Phe Glu Gln Leu Ser 
            20                  25                  


<210> 166
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CASP-5"

<400> 166
Phe Leu Ile Ile Trp Gln Asn Thr Met Gly 
1               5                   10  


<210> 167
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CASP-8"

<400> 167
Phe Pro Ser Asp Ser Trp Cys Tyr Phe 
1               5                   


<210> 168
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="beta-catenin"

<400> 168
Ser Tyr Leu Asp Ser Gly Ile His Phe 
1               5                   


<210> 169
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Cdc27"

<400> 169
Phe Ser Trp Ala Met Asp Leu Asp Pro Lys Gly Ala Glu 
1               5                   10              


<210> 170
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CDK4"

<400> 170
Ala Cys Asp Pro His Ser Gly His Phe Val 
1               5                   10  


<210> 171
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CDK12"

<400> 171
Cys Ile Leu Gly Lys Leu Phe Thr Lys 
1               5                   


<210> 172
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CDKN2A"

<400> 172
Ala Val Cys Pro Trp Thr Trp Leu Arg Gly 
1               5                   10  


<210> 173
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CLPP"

<400> 173
Ile Leu Asp Lys Val Leu Val His Leu 
1               5                   


<210> 174
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="COA-1"

<400> 174
Thr Leu Tyr Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Glu 
1               5                   10                  15  


<210> 175
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CSNK1A1"

<400> 175
Gly Leu Phe Gly Asp Ile Tyr Leu Ala 
1               5                   


<210> 176
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="dek-can fusion protein"

<400> 176
Thr Met Lys Gln Ile Cys Lys Lys Glu Ile Arg Arg Leu His Gln Tyr 
1               5                   10                  15      


<210> 177
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="EFTUD2"

<400> 177
Lys Ile Leu Asp Ala Val Val Ala Gln Lys 
1               5                   10  


<210> 178
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Elongation factor 2"

<400> 178
Glu Thr Val Ser Glu Gln Ser Asn Val 
1               5                   


<210> 179
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="ETV6-AML1 fusion protein"

<400> 179
Arg Ile Ala Glu Cys Ile Leu Gly Met Ile 
1               5                   10  


<210> 180
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="ETV6-AML1 fusion protein"

<400> 180
Ile Gly Arg Ile Ala Glu Cys Ile Leu Gly Met Asn Pro Ser Arg 
1               5                   10                  15  


<210> 181
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="FLT3-ITD"

<400> 181
Tyr Val Asp Phe Arg Glu Tyr Glu Tyr Tyr 
1               5                   10  


<210> 182
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="FNDC3B"

<400> 182
Val Val Met Ser Trp Ala Pro Pro Val 
1               5                   


<210> 183
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="FN1"

<400> 183
Met Ile Phe Glu Lys His Gly Phe Arg Arg Thr Thr Pro Pro 
1               5                   10                  


<210> 184
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="GAS7"

<400> 184
Ser Leu Ala Asp Glu Ala Glu Val Tyr Leu 
1               5                   10  


<210> 185
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="GPNMB"

<400> 185
Thr Leu Asp Trp Leu Leu Gln Thr Pro Lys 
1               5                   10  


<210> 186
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HAUS3"

<400> 186
Ile Leu Asn Ala Met Ile Ala Lys Ile 
1               5                   


<210> 187
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HSDL1"

<400> 187
Cys Tyr Met Glu Ala Val Ala Leu 
1               5               


<210> 188
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LDLR-fucosyltransferaseAS"

<400> 188
Trp Arg Arg Ala Pro Ala Pro Gly Ala 
1               5                   


<210> 189
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="fusion protein"

<400> 189
Pro Val Thr Trp Arg Arg Ala Pro Ala 
1               5                   


<210> 190

<400> 190
000


<210> 191

<400> 191
000


<210> 192
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="hsp70-2"

<400> 192
Ser Leu Phe Glu Gly Ile Asp Ile Tyr Thr 
1               5                   10  


<210> 193
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="hsp70-2"

<400> 193
Ala Glu Pro Ile Asn Ile Gln Thr Trp 
1               5                   


<210> 194
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MART2"

<400> 194
Phe Leu Glu Gly Asn Glu Val Gly Lys Thr Tyr 
1               5                   10      


<210> 195
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MATN"

<400> 195
Lys Thr Leu Thr Ser Val Phe Gln Lys 
1               5                   


<210> 196
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="ME1"

<400> 196
Phe Leu Asp Glu Phe Met Glu Gly Val 
1               5                   


<210> 197
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MUM-1f"

<400> 197
Glu Glu Lys Leu Ile Val Val Leu Phe 
1               5                   


<210> 198
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MUM-2"

<400> 198
Ser Glu Leu Phe Arg Ser Gly Leu Asp Ser Tyr 
1               5                   10      


<210> 199
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MUM-2"

<400> 199
Phe Arg Ser Gly Leu Asp Ser Tyr Val 
1               5                   


<210> 200
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MUM-3"

<400> 200
Glu Ala Phe Ile Gln Pro Ile Thr Arg 
1               5                   


<210> 201
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="neo-PAP"

<400> 201
Arg Val Ile Lys Asn Ser Ile Arg Leu Thr Leu Glu 
1               5                   10          


<210> 202
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Myosin class I"

<400> 202
Lys Ile Asn Lys Asn Pro Lys Tyr Lys 
1               5                   


<210> 203
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NFYC"

<400> 203
Gln Gln Ile Thr Lys Thr Glu Val 
1               5               


<210> 204
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="OGT"

<400> 204
Ser Leu Tyr Lys Phe Ser Pro Phe Pro Leu Gly 
1               5                   10      


<210> 205
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="OS-9"

<400> 205
Lys Glu Leu Glu Gly Ile Leu Leu Leu 
1               5                   


<210> 206
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="p53"

<400> 206
Val Val Pro Cys Glu Pro Pro Glu Val 
1               5                   


<210> 207
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="pml-RARalpha fusion protein"

<400> 207
Asn Ser Asn His Val Ala Ser Gly Ala Gly Glu Ala Ala Ile Glu Thr 
1               5                   10                  15      


Gln Ser Ser Ser Ser Glu Glu Ile Val 
            20                  25  


<210> 208
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PPP1R3B"

<400> 208
Tyr Thr Asp Phe His Cys Gln Tyr Val 
1               5                   


<210> 209
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PRDX5"

<400> 209
Leu Leu Leu Asp Asp Leu Leu Val Ser Ile 
1               5                   10  


<210> 210
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PTPRK"

<400> 210
Pro Tyr Tyr Phe Ala Ala Glu Leu Pro Pro Arg Asn Leu Pro Glu Pro 
1               5                   10                  15      


<210> 211
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="K-ras"

<400> 211
Val Val Val Gly Ala Val Gly Val Gly 
1               5                   


<210> 212
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="N-ras"

<400> 212
Ile Leu Asp Thr Ala Gly Arg Glu Glu Tyr 
1               5                   10  


<210> 213
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="RBAF600"

<400> 213
Arg Pro His Val Pro Glu Ser Ala Phe 
1               5                   


<210> 214
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SIRT2"

<400> 214
Lys Ile Phe Ser Glu Val Thr Leu Lys 
1               5                   


<210> 215
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SNRPD1"

<400> 215
Ser His Glu Thr Val Ile Ile Glu Leu 
1               5                   


<210> 216
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SYT-SSX1 or -SSX2 fusion protein"

<400> 216
Gln Arg Pro Tyr Gly Tyr Asp Gln Ile Met 
1               5                   10  


<210> 217
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TGF-betaRII"

<400> 217
Arg Leu Ser Ser Cys Val Pro Val Ala Gly 
1               5                   10  


<210> 218
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Triosephosphate isomerase"

<400> 218
Gly Glu Leu Ile Gly Ile Leu Asn Ala Ala Lys Val Pro Ala Asp 
1               5                   10                  15  


<210> 219
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Cyclin-A1"

<400> 219
Phe Leu Asp Arg Phe Leu Ser Cys Met 
1               5                   


<210> 220
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Cyclin-A1"

<400> 220
Ser Leu Ile Ala Ala Ala Ala Phe Cys Leu Ala 
1               5                   10      


<210> 221
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="GAGE-1,2,8"

<400> 221
Tyr Arg Pro Arg Pro Arg Arg Tyr 
1               5               


<210> 222
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="GAGE-3,4,5,6,7"

<400> 222
Tyr Tyr Trp Pro Arg Pro Arg Arg Tyr 
1               5                   


<210> 223
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="GnTVf"


<220>
<221> VARIANT
<222> (10)..(10) 
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(10)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 223
Val Leu Pro Asp Val Phe Ile Arg Cys Val 
1               5                   10  


<210> 224
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HERV-K-MEL"

<400> 224
Met Leu Ala Val Ile Ser Cys Ala Val 
1               5                   


<210> 225
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="KK-LC-1"

<400> 225
Arg Gln Lys Arg Ile Leu Val Asn Leu 
1               5                   


<210> 226
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="KM-HN-1"

<400> 226
Asn Tyr Asn Asn Phe Tyr Arg Phe Leu 
1               5                   


<210> 227
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="KM-HN-1"

<400> 227
Glu Tyr Ser Lys Glu Cys Leu Lys Glu Phe 
1               5                   10  


<210> 228
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="KM-HN-1"

<400> 228
Glu Tyr Leu Ser Leu Ser Asp Lys Ile 
1               5                   


<210> 229
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LAGE-1"

<400> 229
Met Leu Met Ala Gln Glu Ala Leu Ala Phe Leu 
1               5                   10      


<210> 230
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LAGE-1"

<400> 230
Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210> 231
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LAGE-1"

<400> 231
Leu Ala Ala Gln Glu Arg Arg Val Pro Arg 
1               5                   10  


<210> 232
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LAGE-1"

<400> 232
Glu Leu Val Arg Arg Ile Leu Ser Arg 
1               5                   


<210> 233
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LAGE-1"

<400> 233
Ala Pro Arg Gly Val Arg Met Ala Val 
1               5                   


<210> 234
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LAGE-1"

<400> 234
Ser Leu Leu Met Trp Ile Thr Gln Cys Phe Leu Pro Val Phe 
1               5                   10                  


<210> 235
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LAGE-1"

<400> 235
Gln Gly Ala Met Leu Ala Ala Gln Glu Arg Arg Val Pro Arg Ala Ala 
1               5                   10                  15      


Glu Val Pro Arg 
            20  


<210> 236
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LAGE-1"

<400> 236
Ala Ala Asp His Arg Gln Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln 
1               5                   10                  15      


Gln Leu 
        


<210> 237
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LAGE-1"

<400> 237
Cys Leu Ser Arg Arg Pro Trp Lys Arg Ser Trp Ser Ala Gly Ser Cys 
1               5                   10                  15      


Pro Gly Met Pro His Leu 
            20          


<210> 238
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LAGE-1"

<400> 238
Ile Leu Ser Arg Asp Ala Ala Pro Leu Pro Arg Pro Gly 
1               5                   10              


<210> 239
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LAGE-1"

<400> 239
Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala Gly Ala 
1               5                   10                  


<210> 240
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LY6K"

<400> 240
Arg Tyr Cys Asn Leu Glu Gly Pro Pro Ile 
1               5                   10  


<210> 241
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LY6K"

<400> 241
Lys Trp Thr Glu Pro Tyr Cys Val Ile Ala Ala Val Lys Ile Phe Pro 
1               5                   10                  15      


Arg Phe Phe Met Val Ala Lys Gln 
            20                  


<210> 242
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="LY6K"

<400> 242
Lys Cys Cys Lys Ile Arg Tyr Cys Asn Leu Glu Gly Pro Pro Ile Asn 
1               5                   10                  15      


Ser Ser Val Phe 
            20  


<210> 243
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 243
Glu Ala Asp Pro Thr Gly His Ser Tyr 
1               5                   


<210> 244
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 244
Ser Leu Phe Arg Ala Val Ile Thr Lys 
1               5                   


<210> 245
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 245
Glu Val Tyr Asp Gly Arg Glu His Ser Ala 
1               5                   10  


<210> 246
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 246
Arg Val Arg Phe Phe Phe Pro Ser Leu 
1               5                   


<210> 247
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 247
Glu Ala Asp Pro Thr Gly His Ser Tyr 
1               5                   


<210> 248
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 248
Arg Glu Pro Val Thr Lys Ala Glu Met Leu 
1               5                   10  


<210> 249
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 249
Lys Glu Ala Asp Pro Thr Gly His Ser Tyr 
1               5                   10  


<210> 250
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 250
Asp Pro Ala Arg Tyr Glu Phe Leu Trp 
1               5                   


<210> 251
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 251
Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 
1               5                   10      


<210> 252
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 252
Ser Ala Phe Pro Thr Thr Ile Asn Phe 
1               5                   


<210> 253
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 253
Ser Ala Tyr Gly Glu Pro Arg Lys Leu 
1               5                   


<210> 254
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 254
Arg Val Arg Phe Phe Phe Pro Ser Leu 
1               5                   


<210> 255
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 255
Ser Ala Tyr Gly Glu Pro Arg Lys Leu 
1               5                   


<210> 256
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 256
Thr Ser Cys Ile Leu Glu Ser Leu Phe Arg Ala Val Ile Thr Lys 
1               5                   10                  15  


<210> 257
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 257
Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr 
1               5                   10                  15  


<210> 258
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 258
Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu 
1               5                   10                  15      


<210> 259
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A1"

<400> 259
Glu Tyr Val Ile Lys Val Ser Ala Arg Val Arg Phe 
1               5                   10          


<210> 260
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A2"

<400> 260
Tyr Leu Gln Leu Val Phe Gly Ile Glu Val 
1               5                   10  


<210> 261
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A2"

<400> 261
Glu Tyr Leu Gln Leu Val Phe Gly Ile 
1               5                   


<210> 262
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A2"

<400> 262
Arg Glu Pro Val Thr Lys Ala Glu Met Leu 
1               5                   10  


<210> 263
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A2"

<400> 263
Glu Gly Asp Cys Ala Pro Glu Glu Lys 
1               5                   


<210> 264
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A2"

<400> 264
Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu 
1               5                   10                  


<210> 265
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 265
Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   


<210> 266
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 266
Phe Leu Trp Gly Pro Arg Ala Leu Val Asp 
1               5                   10  


<210> 267
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 267
Lys Val Ala Glu Leu Val His Phe Leu 
1               5                   


<210> 268
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 268
Thr Phe Pro Asp Leu Glu Ser Glu Phe 
1               5                   


<210> 269
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 269
Val Ala Glu Leu Val His Phe Leu Leu 
1               5                   


<210> 270
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 270
Met Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   10  


<210> 271
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 271
Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   


<210> 272
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 272
Arg Glu Pro Val Thr Lys Ala Glu Met Leu 
1               5                   10  


<210> 273
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 273
Ala Glu Leu Val His Phe Leu Leu Leu Ile 
1               5                   10  


<210> 274
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 274
Met Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   10  


<210> 275
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 275
Trp Gln Tyr Phe Phe Pro Val Ile Phe 
1               5                   


<210> 276
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 276
Glu Gly Asp Cys Ala Pro Glu Glu Lys 
1               5                   


<210> 277
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 277
Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu Tyr 
1               5                   10                  15      


<210> 278
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 278
Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg 
1               5                   10                  15  


<210> 279
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 279
Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu Tyr 
1               5                   10                  15      


<210> 280
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 280
Ala Cys Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Val Glu Thr Ser 
1               5                   10                  15      


<210> 281
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 281
Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg 
1               5                   10                  15  


<210> 282
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 282
Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
1               5                   10          


<210> 283
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 283
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu 
1               5                   10                  15  


<210> 284
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 284
Gly Asp Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val 
1               5                   10                  15  


<210> 285
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 285
Thr Ser Tyr Val Lys Val Leu His His Met Val Lys Ile Ser Gly 
1               5                   10                  15  


<210> 286
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 286
Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala 
1               5                   10                  15      


<210> 287
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A3"

<400> 287
Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu 
1               5                   10                  15      


<210> 288
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A4"

<400> 288
Glu Val Asp Pro Ala Ser Asn Thr Tyr 
1               5                   


<210> 289
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A4"

<400> 289
Gly Val Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210> 290
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A4"

<400> 290
Asn Tyr Lys Arg Cys Phe Pro Val Ile 
1               5                   


<210> 291
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A4"

<400> 291
Ser Glu Ser Leu Lys Met Ile Phe 
1               5               


<210> 292
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A6"

<400> 292
Met Val Lys Ile Ser Gly Gly Pro Arg 
1               5                   


<210> 293
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A6"

<400> 293
Glu Val Asp Pro Ile Gly His Val Tyr 
1               5                   


<210> 294
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A6"

<400> 294
Arg Glu Pro Val Thr Lys Ala Glu Met Leu 
1               5                   10  


<210> 295
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A6"

<400> 295
Glu Gly Asp Cys Ala Pro Glu Glu Lys 
1               5                   


<210> 296
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A6"

<400> 296
Ile Ser Gly Gly Pro Arg Ile Ser Tyr 
1               5                   


<210> 297
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A6"

<400> 297
Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu 
1               5                   10                  


<210> 298
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A9"

<400> 298
Ala Leu Ser Val Met Gly Val Tyr Val 
1               5                   


<210> 299
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A10"

<400> 299
Gly Leu Tyr Asp Gly Met Glu His Leu Leu 
1               5                   10  


<210> 300
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A10"

<400> 300
Asp Pro Ala Arg Tyr Glu Phe Leu Trp 
1               5                   


<210> 301
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A12 m"

<400> 301
Phe Leu Trp Gly Pro Arg Ala Leu Val Glu 
1               5                   10  


<210> 302
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A12 m"

<400> 302
Val Arg Ile Gly His Leu Tyr Ile Leu 
1               5                   


<210> 303
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A12 m"

<400> 303
Glu Gly Asp Cys Ala Pro Glu Glu Lys 
1               5                   


<210> 304
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A12 m"

<400> 304
Arg Glu Pro Phe Thr Lys Ala Glu Met Leu Gly Ser Val Ile Arg 
1               5                   10                  15  


<210> 305
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-A12 m"

<400> 305
Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg 
1               5                   10                  


<210> 306
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-C1"

<400> 306
Ile Leu Phe Gly Ile Ser Leu Arg Glu Val 
1               5                   10  


<210> 307
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-C1"

<400> 307
Lys Val Val Glu Phe Leu Ala Met Leu 
1               5                   


<210> 308
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-C1"

<400> 308
Ser Ser Ala Leu Leu Ser Ile Phe Gln Ser Ser Pro Glu 
1               5                   10              


<210> 309
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-C1"

<400> 309
Ser Phe Ser Tyr Thr Leu Leu Ser Leu 
1               5                   


<210> 310
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-C1"

<400> 310
Val Ser Ser Phe Phe Ser Tyr Thr Leu 
1               5                   


<210> 311
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-C2"

<400> 311
Leu Leu Phe Gly Leu Ala Leu Ile Glu Val 
1               5                   10  


<210> 312
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-C2"

<400> 312
Ala Leu Lys Asp Val Glu Glu Arg Val 
1               5                   


<210> 313
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-C2"

<400> 313
Ser Glu Ser Ile Lys Lys Lys Val Leu 
1               5                   


<210> 314
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-C2"

<400> 314
Ala Ser Ser Thr Leu Tyr Leu Val Phe 
1               5                   


<210> 315
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MAGE-C2"

<400> 315
Ser Ser Thr Leu Tyr Leu Val Phe Ser Pro Ser Ser Phe Ser Thr 
1               5                   10                  15  


<210> 316
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="mucink"

<400> 316
Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly 
1               5                   10                  15      


Val Thr Ser Ala 
            20  


<210> 317
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NA88-A"

<400> 317
Gln Gly Gln His Phe Leu Gln Lys Val 
1               5                   


<210> 318
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 318
Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210> 319
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 319
Met Leu Met Ala Gln Glu Ala Leu Ala Phe Leu 
1               5                   10      


<210> 320
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 320
Tyr Leu Ala Met Pro Phe Ala Thr Pro Met Glu 
1               5                   10      


<210> 321
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 321
Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg 
1               5                   10  


<210> 322
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 322
Leu Ala Ala Gln Glu Arg Arg Val Pro Arg 
1               5                   10  


<210> 323
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 323
Thr Val Ser Gly Asn Ile Leu Thr Ile Arg 
1               5                   10  


<210> 324
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 324
Ala Pro Arg Gly Pro His Gly Gly Ala Ala Ser Gly Leu 
1               5                   10              


<210> 325
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 325
Met Pro Phe Ala Thr Pro Met Glu Ala Glu Leu 
1               5                   10      


<210> 326
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 326
Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr Ile 
1               5                   10          


<210> 327
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 327
Met Pro Phe Ala Thr Pro Met Glu Ala 
1               5                   


<210> 328
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 328
Phe Ala Thr Pro Met Glu Ala Glu Leu 
1               5                   


<210> 329
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 329
Phe Ala Thr Pro Met Glu Ala Glu Leu Ala Arg 
1               5                   10      


<210> 330
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 330
Leu Ala Met Pro Phe Ala Thr Pro Met 
1               5                   


<210> 331
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 331
Ala Arg Gly Pro Glu Ser Arg Leu Leu 
1               5                   


<210> 332
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 332
Ser Leu Leu Met Trp Ile Thr Gln Cys Phe Leu Pro Val Phe 
1               5                   10                  


<210> 333
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 333
Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe Ala Thr Pro Met Glu Ala 
1               5                   10                  15      


Glu Leu Ala Arg Arg Ser Leu Ala Gln 
            20                  25  


<210> 334
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 334
Glu Phe Tyr Leu Ala Met Pro Phe Ala Thr Pro Met 
1               5                   10          


<210> 335
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 335
Pro Gly Val Leu Leu Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr 
1               5                   10                  15      


Ile Arg Leu Thr Ala Ala Asp His Arg 
            20                  25  


<210> 336
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 336
Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe Ala 
1               5                   10          


<210> 337
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 337
Gln Gly Ala Met Leu Ala Ala Gln Glu Arg Arg Val Pro Arg Ala Ala 
1               5                   10                  15      


Glu Val Pro Arg 
            20  


<210> 338
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 338
Pro Phe Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg 
1               5                   10              


<210> 339
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 339
Pro Gly Val Leu Leu Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr 
1               5                   10                  15      


Ile Arg Leu Thr 
            20  


<210> 340
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 340
Val Leu Leu Lys Glu Phe Thr Val Ser Gly 
1               5                   10  


<210> 341
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 341
Ala Ala Asp His Arg Gln Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln 
1               5                   10                  15      


Gln Leu 
        


<210> 342
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 342
Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe Ala Thr Pro Met Glu Ala 
1               5                   10                  15      


Glu Leu Ala Arg Arg Ser Leu Ala Gln 
            20                  25  


<210> 343
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 343
Leu Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr Ile Arg Leu 
1               5                   10                  15  


<210> 344
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 344
Pro Gly Val Leu Leu Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr 
1               5                   10                  15      


Ile Arg Leu Thr Ala Ala Asp His Arg 
            20                  25  


<210> 345
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 345
Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr 
1               5                   10      


<210> 346
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 346
Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe Ala Thr Pro Met 
1               5                   10                  


<210> 347
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-ESO-1 / LAGE-2"

<400> 347
Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala Gly Ala 
1               5                   10                  


<210> 348
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SAGE"

<400> 348
Leu Tyr Ala Thr Val Ile His Asp Ile 
1               5                   


<210> 349
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Sp17"

<400> 349
Ile Leu Asp Ser Ser Glu Glu Asp Lys 
1               5                   


<210> 350
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-2"

<400> 350
Lys Ala Ser Glu Lys Ile Phe Tyr Val 
1               5                   


<210> 351
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-2"

<400> 351
Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe Ser Lys 
1               5                   10                  15      


<210> 352
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-2"

<400> 352
Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile 
1               5                   10      


<210> 353
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-2"

<400> 353
Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr Val Tyr Met Lys 
1               5                   10                  15      


Arg Lys 
        


<210> 354
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-2"

<400> 354
Lys Ile Phe Tyr Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr 
1               5                   10                  15  


<210> 355
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-2"

<400> 355
Lys Ile Phe Tyr Val Tyr Met Lys Arg Lys Tyr Glu Ala Met 
1               5                   10                  


<210> 356
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-4"

<400> 356
Ile Asn Lys Thr Ser Gly Pro Lys Arg Gly Lys His Ala Trp Thr His 
1               5                   10                  15      


Arg Leu Arg Glu 
            20  


<210> 357
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-4"

<400> 357
Tyr Phe Ser Lys Lys Glu Trp Glu Lys Met Lys Ser Ser Glu Lys Ile 
1               5                   10                  15      


Val Tyr Val Tyr 
            20  


<210> 358
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-4"

<400> 358
Met Lys Leu Asn Tyr Glu Val Met Thr Lys Leu Gly Phe Lys Val Thr 
1               5                   10                  15      


Leu Pro Pro Phe 
            20  


<210> 359
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-4"

<400> 359
Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Val 
1               5                   10                  15      


Tyr Glu Glu Ile 
            20  


<210> 360
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-4"

<400> 360
Leu Gly Phe Lys Val Thr Leu Pro Pro Phe Met Arg Ser Lys Arg Ala 
1               5                   10                  15      


Ala Asp Phe His 
            20  


<210> 361
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-4"

<400> 361
Lys Ser Ser Glu Lys Ile Val Tyr Val Tyr Met Lys Leu Asn Tyr Glu 
1               5                   10                  15      


Val Met Thr Lys 
            20  


<210> 362
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SSX-4"

<400> 362
Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Val 
1               5                   10                  15      


Tyr Glu Glu Ile 
            20  


<210> 363
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TAG-1"

<400> 363
Ser Leu Gly Trp Leu Phe Leu Leu Leu 
1               5                   


<210> 364
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TAG-1"

<400> 364
Leu Ser Arg Leu Ser Asn Arg Leu Leu 
1               5                   


<210> 365
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRAG-3"

<400> 365
Cys Glu Phe His Ala Cys Trp Pro Ala Phe Thr Val Leu Gly Glu 
1               5                   10                  15  


<210> 366
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRAG-3"

<400> 366
Cys Glu Phe His Ala Cys Trp Pro Ala Phe Thr Val Leu Gly Glu 
1               5                   10                  15  


<210> 367
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRP2-INT2g"

<400> 367
Glu Val Ile Ser Cys Lys Leu Ile Lys Arg 
1               5                   10  


<210> 368
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="XAGE-1b/GAGED2a"

<400> 368
Arg Gln Lys Lys Ile Arg Ile Gln Leu 
1               5                   


<210> 369
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="XAGE-1b/GAGED2a"

<400> 369
His Leu Gly Ser Arg Gln Lys Lys Ile Arg Ile Gln Leu Arg Ser Gln 
1               5                   10                  15      


<210> 370
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="XAGE-1b/GAGED2a"

<400> 370
Cys Ala Thr Trp Lys Val Ile Cys Lys Ser Cys Ile Ser Gln Thr Pro 
1               5                   10                  15      


Gly 
    


<210> 371
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 371
Tyr Leu Ser Gly Ala Asn Leu Asn Leu Gly 
1               5                   10  


<210> 372
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 372
Ile Met Ile Gly Val Leu Val Gly Val 
1               5                   


<210> 373
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 373
Gly Val Leu Val Gly Val Ala Leu Ile 
1               5                   


<210> 374
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 374
His Leu Phe Gly Tyr Ser Trp Tyr Lys 
1               5                   


<210> 375
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 375
Gln Tyr Ser Trp Phe Val Asn Gly Thr Phe 
1               5                   10  


<210> 376
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 376
Thr Tyr Ala Cys Phe Val Ser Asn Leu 
1               5                   


<210> 377
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 377
Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser 
1               5                   10                  15  


<210> 378
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 378
Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val Asn 
1               5                   10                  15      


Glu Glu Ala Thr Gly Gln Phe Arg Val 
            20                  25  


<210> 379
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 379
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val 
1               5                   10                  15  


<210> 380
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 380
Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser Cys 
1               5                   10              


<210> 381
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 381
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn 
1               5                   10              


<210> 382
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 382
Tyr Ala Cys Phe Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser 
1               5                   10                  15  


<210> 383
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 383
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro 
1               5                   10              


<210> 384
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 384
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn 
1               5                   10              


<210> 385
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CEA"

<400> 385
Asn Ser Ile Val Lys Ser Ile Thr Val Ser Ala Ser Gly 
1               5                   10              


<210> 386
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 386
Lys Thr Trp Gly Gln Tyr Trp Gln Val 
1               5                   


<210> 387
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"


<220>
<221> VARIANT
<222> (1)..(1) 
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(10)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 387
Ala Met Leu Gly Thr His Thr Met Glu Val 
1               5                   10  


<210> 388
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 388
Ile Thr Asp Gln Val Pro Phe Ser Val 
1               5                   


<210> 389
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 389
Tyr Leu Glu Pro Gly Pro Val Thr Ala 
1               5                   


<210> 390
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 390
Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu 
1               5                   10  


<210> 391
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 391
Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val 
1               5                   10  


<210> 392
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 392
Ser Leu Ala Asp Thr Asn Ser Leu Ala Val 
1               5                   10  


<210> 393
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 393
Arg Leu Met Lys Gln Asp Phe Ser Val 
1               5                   


<210> 394
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 394
Arg Leu Pro Arg Ile Phe Cys Ser Cys 
1               5                   


<210> 395
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 395
Leu Ile Tyr Arg Arg Arg Leu Met Lys 
1               5                   


<210> 396
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 396
Ala Leu Leu Ala Val Gly Ala Thr Lys 
1               5                   


<210> 397
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 397
Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys 
1               5                   10  


<210> 398
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 398
Arg Ser Tyr Val Pro Leu Ala His Arg 
1               5                   


<210> 399
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 399
Ala Leu Asn Phe Pro Gly Ser Gln Lys 
1               5                   


<210> 400
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 400
Val Tyr Phe Phe Leu Pro Asp His Leu 
1               5                   


<210> 401
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 401
Arg Thr Lys Gln Leu Tyr Pro Glu Trp 
1               5                   


<210> 402
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 402
His Thr Met Glu Val Thr Val Tyr His Arg 
1               5                   10  


<210> 403
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 403
Ser Ser Pro Gly Cys Gln Pro Pro Ala 
1               5                   


<210> 404
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 404
Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
1               5                   10  


<210> 405
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 405
Leu Pro His Ser Ser Ser His Trp Leu 
1               5                   


<210> 406
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 406
Ser Asn Asp Gly Pro Thr Leu Ile 
1               5               


<210> 407
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 407
Gly Arg Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr 
1               5                   10                  15  


<210> 408
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 408
Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp 
1               5                   10                  15      


<210> 409
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 409
Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro Ile Pro Glu 
1               5                   10                  15      


Pro Glu 
        


<210> 410
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="gp100 / Pmel17"

<400> 410
Thr Gly Arg Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr 
1               5                   10                  15      


His 
    


<210> 411
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="mammaglobin-A"

<400> 411
Pro Leu Leu Glu Asn Val Ile Ser Lys 
1               5                   


<210> 412
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Melan-A / MART-1"

<400> 412
Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile Leu Thr Val Ile 
1               5                   10                  15      


Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys Arg Arg 
            20                  25                  30  


<210> 413
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Melan-A / MART-1"

<400> 413
Ala Ala Gly Ile Gly Ile Leu Thr Val Ile Leu Gly Val Leu 
1               5                   10                  


<210> 414
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Melan-A / MART-1"

<400> 414
Ala Pro Pro Ala Tyr Glu Lys Leu Pro Ser Ala Glu Gln Phe 
1               5                   10                  


<210> 415
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Melan-A / MART-1"

<400> 415
Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val Gly Thr 
1               5                   10                  15      


Gln Cys Ala Leu Thr Arg Arg 
            20              


<210> 416
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Melan-A / MART-1"

<400> 416
Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser 
            20  


<210> 417
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Melan-A / MART-1"

<400> 417
Lys Asn Cys Glu Pro Val Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys 
1               5                   10                  15      


Leu Ser Ala Glu 
            20  


<210> 418
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="NY-BR-1"

<400> 418
Ser Leu Ser Lys Ile Leu Asp Thr Val 
1               5                   


<210> 419
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="OA1"

<400> 419
Leu Tyr Ser Ala Cys Phe Trp Trp Leu 
1               5                   


<210> 420
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PAP"

<400> 420
Phe Leu Phe Leu Leu Phe Phe Trp Leu 
1               5                   


<210> 421
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PAP"

<400> 421
Thr Leu Met Ser Ala Met Thr Asn Leu 
1               5                   


<210> 422
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PAP"

<400> 422
Ala Leu Asp Val Tyr Asn Gly Leu Leu 
1               5                   


<210> 423
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PSA"

<400> 423
Phe Leu Thr Pro Lys Lys Leu Gln Cys Val 
1               5                   10  


<210> 424
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PSA"

<400> 424
Val Ile Ser Asn Asp Val Cys Ala Gln Val 
1               5                   10  


<210> 425
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="RAB38 / NY-MEL-1"

<400> 425
Val Leu His Trp Asp Pro Glu Thr Val 
1               5                   


<210> 426
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRP-1 / gp75"

<400> 426
Met Ser Leu Gln Arg Gln Phe Leu Arg 
1               5                   


<210> 427
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRP-1 / gp75"

<400> 427
Ile Ser Pro Asn Ser Val Phe Ser Gln Trp Arg Val Val Cys Asp Ser 
1               5                   10                  15      


Leu Glu Asp Tyr Asp 
            20      


<210> 428
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRP-1 / gp75"

<400> 428
Ser Leu Pro Tyr Trp Asn Phe Ala Thr Gly 
1               5                   10  


<210> 429
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRP-1 / gp75"

<400> 429
Ser Gln Trp Arg Val Val Cys Asp Ser Leu Glu Asp Tyr Asp Thr 
1               5                   10                  15  


<210> 430
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRP-2"

<400> 430
Ser Val Tyr Asp Phe Phe Val Trp Leu 
1               5                   


<210> 431
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRP-2"

<400> 431
Thr Leu Asp Ser Gln Val Met Ser Leu 
1               5                   


<210> 432
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRP-2"

<400> 432
Leu Leu Gly Pro Gly Arg Pro Tyr Arg 
1               5                   


<210> 433
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRP-2"

<400> 433
Ala Asn Asp Pro Ile Phe Val Val Leu 
1               5                   


<210> 434
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRP-2"

<400> 434
Gln Cys Thr Glu Val Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro 
1               5                   10                  15  


<210> 435
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TRP-2"

<400> 435
Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly 
1               5                   10  


<210> 436
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 436
Lys Cys Asp Ile Cys Thr Asp Glu Tyr 
1               5                   


<210> 437
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 437
Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr 
1               5                   10      


<210> 438
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 438
Met Leu Leu Ala Val Leu Tyr Cys Leu 
1               5                   


<210> 439
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 439
Cys Leu Leu Trp Ser Phe Gln Thr Ser Ala 
1               5                   10  


<210> 440
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 440
Tyr Met Asp Gly Thr Met Ser Gln Val 
1               5                   


<210> 441
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 441
Ala Phe Leu Pro Trp His Arg Leu Phe 
1               5                   


<210> 442
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 442
Ile Tyr Met Asp Gly Thr Ala Asp Phe Ser Phe 
1               5                   10      


<210> 443
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 443
Gln Cys Ser Gly Asn Phe Met Gly Phe 
1               5                   


<210> 444
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 444
Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
1               5                   10          


<210> 445
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 445
Leu Pro Ser Ser Ala Asp Val Glu Phe 
1               5                   


<210> 446
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 446
Leu His His Ala Phe Val Asp Ser Ile Phe 
1               5                   10  


<210> 447
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 447
Ser Glu Ile Trp Arg Asp Ile Asp Phe Asp 
1               5                   10  


<210> 448
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 448
Gln Asn Ile Leu Leu Ser Asn Ala Pro Leu Gly Pro Gln Phe Pro 
1               5                   10                  15  


<210> 449
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 449
Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp 
1               5                   10              


<210> 450
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="tyrosinase"

<400> 450
Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp Leu 
1               5                   10                  15      


Gln Arg His Arg Pro 
            20      


<210> 451
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="adipophilin"

<400> 451
Ser Val Ala Ser Thr Ile Thr Gly Val 
1               5                   


<210> 452
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="AIM-2"

<400> 452
Arg Ser Asp Ser Gly Gln Gln Ala Arg Tyr 
1               5                   10  


<210> 453
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="ALDH1A1"

<400> 453
Leu Leu Tyr Lys Leu Ala Asp Leu Ile 
1               5                   


<210> 454
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="BCLX(L)"

<400> 454
Tyr Leu Asn Asp His Leu Glu Pro Trp Ile 
1               5                   10  


<210> 455
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="BING-4"

<400> 455
Cys Gln Trp Gly Arg Leu Trp Gln Leu 
1               5                   


<210> 456
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CALCA"

<400> 456
Val Leu Leu Gln Ala Gly Ser Leu His Ala 
1               5                   10  


<210> 457
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CD45"

<400> 457
Lys Phe Leu Asp Ala Leu Ile Ser Leu 
1               5                   


<210> 458
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CD274"

<400> 458
Leu Leu Asn Ala Phe Thr Val Thr Val 
1               5                   


<210> 459
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CPSF"

<400> 459
Lys Val His Pro Val Ile Trp Ser Leu 
1               5                   


<210> 460
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="peptide"

<400> 460
Leu Met Leu Gln Asn Ala Leu Thr Thr Met 
1               5                   10  


<210> 461
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="cyclinD1"

<400> 461
Leu Leu Gly Ala Thr Cys Met Phe Val 
1               5                   


<210> 462
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="peptide"

<400> 462
Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val Val Ala Ala Val 
1               5                   10                  15  


<210> 463
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="DKK1"

<400> 463
Ala Leu Gly Gly His Pro Leu Leu Gly Val 
1               5                   10  


<210> 464
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="ENAH(hMena)"

<400> 464
Thr Met Asn Gly Ser Lys Ser Pro Val 
1               5                   


<210> 465
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="EpCAM"

<400> 465
Arg Tyr Gln Leu Asp Pro Lys Phe Ile 
1               5                   


<210> 466
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="EphA3"

<400> 466
Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly 
1               5                   10          


<210> 467
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="EZH2"

<400> 467
Phe Met Val Glu Asp Glu Thr Val Leu 
1               5                   


<210> 468
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="FGF5"

<400> 468
Asn Thr Tyr Ala Ser Pro Arg Phe Lys Phe 
1               5                   10  


<210> 469
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="glypican-3"

<400> 469
Phe Val Gly Glu Phe Phe Thr Asp Val 
1               5                   


<210> 470
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="G250 / MN / CAIX"

<400> 470
His Leu Ser Thr Ala Phe Ala Arg Val 
1               5                   


<210> 471
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 471
Lys Ile Phe Gly Ser Leu Ala Phe Leu 
1               5                   


<210> 472
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 472
Ile Ile Ser Ala Val Val Gly Ile Leu 
1               5                   


<210> 473
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 473
Ala Leu Cys Arg Trp Gly Leu Leu Leu 
1               5                   


<210> 474
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 474
Ile Leu His Asn Gly Ala Tyr Ser Leu 
1               5                   


<210> 475
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 475
Arg Leu Leu Gln Glu Thr Glu Leu Val 
1               5                   


<210> 476
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 476
Val Val Leu Gly Val Val Phe Gly Ile 
1               5                   


<210> 477
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 477
Tyr Met Ile Met Val Lys Cys Trp Met Ile 
1               5                   10  


<210> 478
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 478
His Leu Tyr Gln Gly Cys Gln Val Val 
1               5                   


<210> 479
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 479
Tyr Leu Val Pro Gln Gln Gly Phe Phe Cys 
1               5                   10  


<210> 480
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 480
Pro Leu Gln Pro Glu Gln Leu Gln Val 
1               5                   


<210> 481
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 481
Thr Leu Glu Glu Ile Thr Gly Tyr Leu 
1               5                   


<210> 482
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 482
Ala Leu Ile His His Asn Thr His Leu 
1               5                   


<210> 483
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 483
Pro Leu Thr Ser Ile Ile Ser Ala Val 
1               5                   


<210> 484
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 484
Val Leu Arg Glu Asn Thr Ser Pro Lys 
1               5                   


<210> 485
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HER-2 / neu"

<400> 485
Thr Tyr Leu Pro Thr Asn Ala Ser Leu 
1               5                   


<210> 486
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="HLA-DOB"

<400> 486
Phe Leu Leu Gly Leu Ile Phe Leu Leu 
1               5                   


<210> 487
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Hepsin"

<400> 487
Ser Leu Leu Ser Gly Asp Trp Val Leu 
1               5                   


<210> 488
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Hepsin"

<400> 488
Gly Leu Gln Leu Gly Val Gln Ala Val 
1               5                   


<210> 489
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Hepsin"

<400> 489
Pro Leu Thr Glu Tyr Ile Gln Pro Val 
1               5                   


<210> 490
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="IDO1"

<400> 490
Ala Leu Leu Glu Ile Ala Ser Cys Leu 
1               5                   


<210> 491
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="IGF2B3"

<400> 491
Asn Leu Ser Ser Ala Glu Val Val Val 
1               5                   


<210> 492
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="IGF2B3"

<400> 492
Arg Leu Leu Val Pro Thr Gln Phe Val 
1               5                   


<210> 493
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="IL13Ralpha2"

<400> 493
Trp Leu Pro Phe Gly Phe Ile Leu Ile 
1               5                   


<210> 494
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Intestinal carboxyl esterase"

<400> 494
Ser Pro Arg Trp Trp Pro Thr Cys Leu 
1               5                   


<210> 495
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="alpha-foetoprotein"

<400> 495
Gly Val Ala Leu Gln Thr Met Lys Gln 
1               5                   


<210> 496
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="alpha-foetoprotein"

<400> 496
Phe Met Asn Lys Phe Ile Tyr Glu Ile 
1               5                   


<210> 497
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="alpha-foetoprotein"

<400> 497
Gln Leu Ala Val Ser Val Ile Leu Arg Val 
1               5                   10  


<210> 498
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Kallikrein 4"

<400> 498
Phe Leu Gly Tyr Leu Ile Leu Gly Val 
1               5                   


<210> 499
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Kallikrein 4"

<400> 499
Ser Val Ser Glu Ser Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser 
1               5                   10                  15  


<210> 500
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Kallikrein 4"

<400> 500
Leu Leu Ala Asn Gly Arg Met Pro Thr Val Leu Gln Cys Val Asn 
1               5                   10                  15  


<210> 501
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Kallikrein 4"

<400> 501
Arg Met Pro Thr Val Leu Gln Cys Val Asn Val Ser Val Val Ser 
1               5                   10                  15  


<210> 502
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="KIF20A"

<400> 502
Leu Leu Ser Asp Asp Asp Val Val Val 
1               5                   


<210> 503
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="KIF20A"

<400> 503
Ala Gln Pro Asp Thr Ala Pro Leu Pro Val 
1               5                   10  


<210> 504
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="KIF20A"

<400> 504
Cys Ile Ala Glu Gln Tyr His Thr Val 
1               5                   


<210> 505
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Lengsin"

<400> 505
Phe Leu Pro Glu Phe Gly Ile Ser Ser Ala 
1               5                   10  


<210> 506
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="M-CSF"

<400> 506
Leu Pro Ala Val Val Gly Leu Ser Pro Gly Glu Gln Glu Tyr 
1               5                   10                  


<210> 507
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MCSP"

<400> 507
Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr Gly Ala Leu Gln 
1               5                   10                  15      


<210> 508
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="mdm-2"

<400> 508
Val Leu Phe Tyr Leu Gly Gln Tyr 
1               5               


<210> 509
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Meloe"

<400> 509
Thr Leu Asn Asp Glu Cys Trp Pro Ala 
1               5                   


<210> 510
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Meloe"

<400> 510
Glu Arg Ile Ser Ser Thr Leu Asn Asp Glu Cys Trp Pro Ala 
1               5                   10                  


<210> 511
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Meloe"

<400> 511
Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile 
1               5                   10      


<210> 512
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Meloe"

<400> 512
Thr Ser Arg Glu Gln Phe Leu Pro Ser Glu Gly Ala Ala 
1               5                   10              


<210> 513
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Meloe"

<400> 513
Cys Pro Pro Trp His Pro Ser Glu Arg Ile Ser Ser Thr Leu 
1               5                   10                  


<210> 514
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Midkine"

<400> 514
Ala Leu Leu Ala Leu Thr Ser Ala Val 
1               5                   


<210> 515
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Midkine"

<400> 515
Ala Gln Cys Gln Glu Thr Ile Arg Val 
1               5                   


<210> 516
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Midkine"

<400> 516
Leu Thr Leu Leu Ala Leu Leu Ala Leu Thr Ser Ala Val Ala Lys 
1               5                   10                  15  


<210> 517
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MMP-2"

<400> 517
Gly Leu Pro Pro Asp Val Gln Arg Val His 
1               5                   10  


<210> 518
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MMP-7"

<400> 518
Ser Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys 
1               5                   10          


<210> 519
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MUC1"

<400> 519
Ser Thr Ala Pro Pro Val His Asn Val 
1               5                   


<210> 520
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MUC1"

<400> 520
Leu Leu Leu Leu Thr Val Leu Thr Val 
1               5                   


<210> 521
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MUC1"

<400> 521
Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
1               5                   10          


<210> 522
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="MUC5AC"

<400> 522
Thr Cys Gln Pro Thr Cys Arg Ser Leu 
1               5                   


<210> 523
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="p53"

<400> 523
Leu Leu Gly Arg Asn Ser Phe Glu Val 
1               5                   


<210> 524
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="p53"

<400> 524
Arg Met Pro Glu Ala Ala Pro Pro Val 
1               5                   


<210> 525
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="p53"

<400> 525
Ser Gln Lys Thr Tyr Gln Gly Ser Tyr 
1               5                   


<210> 526
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="p53"

<400> 526
Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln 
1               5                   10              


<210> 527
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="p53"

<400> 527
His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu 
1               5                   10          


<210> 528
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PAX5"

<400> 528
Thr Leu Pro Gly Tyr Pro Pro His Val 
1               5                   


<210> 529
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PBF"

<400> 529
Cys Thr Ala Cys Arg Trp Lys Lys Ala Cys Gln Arg 
1               5                   10          


<210> 530
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PRAME"

<400> 530
Val Leu Asp Gly Leu Asp Val Leu Leu 
1               5                   


<210> 531
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PRAME"

<400> 531
Ser Leu Tyr Ser Phe Pro Glu Pro Glu Ala 
1               5                   10  


<210> 532
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PRAME"

<400> 532
Ala Leu Tyr Val Asp Ser Leu Phe Phe Leu 
1               5                   10  


<210> 533
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PRAME"

<400> 533
Ser Leu Leu Gln His Leu Ile Gly Leu 
1               5                   


<210> 534
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PRAME"

<400> 534
Leu Tyr Val Asp Ser Leu Phe Phe Leu Cys 
1               5                   10  


<210> 535
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PSMA"

<400> 535
Asn Tyr Ala Arg Thr Glu Asp Phe Phe 
1               5                   


<210> 536
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="RAGE-1"

<400> 536
Leu Lys Leu Ser Gly Val Val Arg Leu 
1               5                   


<210> 537
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="RAGE-1"

<400> 537
Pro Leu Pro Pro Ala Arg Asn Gly Gly Leu Gly 
1               5                   10      


<210> 538
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="RAGE-1"

<400> 538
Ser Pro Ser Ser Asn Arg Ile Arg Asn Thr 
1               5                   10  


<210> 539
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="RGS5"

<400> 539
Leu Ala Ala Leu Pro His Ser Cys Leu 
1               5                   


<210> 540
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="RGS5"

<400> 540
Gly Leu Ala Ser Phe Lys Ser Phe Leu Lys 
1               5                   10  


<210> 541
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="RhoC"

<400> 541
Arg Ala Gly Leu Gln Val Arg Lys Asn Lys 
1               5                   10  


<210> 542
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="RNF43"


<220>
<221> VARIANT
<222> (10)..(10) 
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(10)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 542
Ala Leu Trp Pro Trp Leu Leu Met Ala Thr 
1               5                   10  


<210> 543
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="RNF43"

<400> 543
Asn Ser Gln Pro Val Trp Leu Cys Leu 
1               5                   


<210> 544
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="RU2AS"

<400> 544
Leu Pro Arg Trp Pro Pro Pro Gln Leu 
1               5                   


<210> 545
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="secernin1"

<400> 545
Lys Met Asp Ala Glu His Pro Glu Leu 
1               5                   


<210> 546
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SOX10"

<400> 546
Ala Trp Ile Ser Lys Pro Pro Gly Val 
1               5                   


<210> 547
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SOX10"

<400> 547
Ser Ala Trp Ile Ser Lys Pro Pro Gly Val 
1               5                   10  


<210> 548
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="STEAP1"

<400> 548
Met Ile Ala Val Phe Leu Pro Ile Val 
1               5                   


<210> 549
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="STEAP1"

<400> 549
His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile Leu Val Ile Asn Lys 
1               5                   10                  15  


<210> 550
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="survivin"

<400> 550
Glu Leu Thr Leu Gly Glu Phe Leu Lys Leu 
1               5                   10  


<210> 551
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="survivin"

<400> 551
Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn 
1               5                   10                  15  


<210> 552
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Telomerase"

<400> 552
Ile Leu Ala Lys Phe Leu His Trp Leu Glu 
1               5                   10  


<210> 553
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Telomerase"

<400> 553
Arg Leu Val Asp Asp Phe Leu Leu Val 
1               5                   


<210> 554
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Telomerase"

<400> 554
Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile 
1               5                   10                  15  


<210> 555
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Telomerase"

<400> 555
Leu Thr Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu 
1               5                   10                  15  


<210> 556
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TPBG"

<400> 556
Arg Leu Ala Arg Leu Ala Leu Val Leu 
1               5                   


<210> 557
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="VEGF"

<400> 557
Ser Arg Phe Gly Gly Ala Val Val Arg 
1               5                   


<210> 558
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="WT1"

<400> 558
Thr Ser Glu Lys Arg Pro Phe Met Cys Ala Tyr 
1               5                   10      


<210> 559
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="WT1"

<400> 559
Cys Met Thr Trp Asn Gln Met Asn Leu 
1               5                   


<210> 560
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="WT1"

<400> 560
Leu Ser His Leu Gln Met His Ser Arg Lys His 
1               5                   10      


<210> 561
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="WT1"

<400> 561
Lys Arg Tyr Phe Lys Leu Ser His Leu Gln Met His Ser Arg Lys His 
1               5                   10                  15      


<210> 562
<211> 504
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="single chain variable fragment fusion protein"

<400> 562
Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 
145                 150                 155                 160 


Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 
                165                 170                 175     


Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 
        195                 200                 205             


Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
    210                 215                 220                 


Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
                245                 250                 255     


Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser 
            260                 265                 270         


Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
        275                 280                 285             


Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    290                 295                 300                 


Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
305                 310                 315                 320 


Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met 
                325                 330                 335     


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro 
385                 390                 395                 400 


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
                405                 410                 415     


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly 
            420                 425                 430         


Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly 
        435                 440                 445             


Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
    450                 455                 460                 


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
                485                 490                 495     


Leu Lys His His His His His His 
            500                 


<210> 563
<211> 290
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FNR Responsive Promoter"

<400> 563
gtcagcataa caccctgacc tctcattaat tgttcatgcc gggcggcact atcgtcgtcc       60

ggccttttcc tctcttactc tgctacgtac atctatttct ataaatccgt tcaatttgtc      120

tgttttttgc acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa      180

tcagcaatat accccttaag gagtatataa aggtgaattt gatttacatc aataagcggg      240

gttgctgaat cgttaaggta ggcggtaata gaaaagaaat cgaggcaaaa                 290


<210> 564
<211> 173
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FNR Responsive Promoter"

<400> 564
atttcctctc atcccatccg gggtgagagt cttttccccc gacttatggc tcatgcatgc       60

atcaaaaaag atgtgagctt gatcaaaaac aaaaaatatt tcactcgaca ggagtattta      120

tattgcgccc gttacgtggg cttcgactgt aaatcagaaa ggagaaaaca cct             173


<210> 565
<211> 305
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FNR Responsive Promoter"

<400> 565
gtcagcataa caccctgacc tctcattaat tgttcatgcc gggcggcact atcgtcgtcc       60

ggccttttcc tctcttactc tgctacgtac atctatttct ataaatccgt tcaatttgtc      120

tgttttttgc acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa      180

tcagcaatat accccttaag gagtatataa aggtgaattt gatttacatc aataagcggg      240

gttgctgaat cgttaaggat ccctctagaa ataattttgt ttaactttaa gaaggagata      300

tacat                                                                  305


<210> 566
<211> 180
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FNR Responsive Promoter"

<400> 566
catttcctct catcccatcc ggggtgagag tcttttcccc cgacttatgg ctcatgcatg       60

catcaaaaaa gatgtgagct tgatcaaaaa caaaaaatat ttcactcgac aggagtattt      120

atattgcgcc cggatccctc tagaaataat tttgtttaac tttaagaagg agatatacat      180


<210> 567
<211> 199
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FNR Responsive Promoter"

<400> 567
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgtaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctctt ggatccctct agaaataatt ttgtttaact      180

ttaagaagga gatatacat                                                   199


<210> 568
<211> 117
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FNR-responsive regulatory region"

<400> 568
atccccatca ctcttgatgg agatcaattc cccaagctgc tagagcgtta ccttgccctt       60

aaacattagc aatgtcgatt tatcagaggg ccgacaggct cccacaggag aaaaccg         117


<210> 569
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FNR-responsive regulatory region"

<400> 569
ctcttgatcg ttatcaattc ccacgctgtt tcagagcgtt accttgccct taaacattag       60

caatgtcgat ttatcagagg gccgacaggc tcccacagga gaaaaccg                   108


<210> 570
<211> 290
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="nirB1 , FNR-responsive regulatory region"

<400> 570
gtcagcataa caccctgacc tctcattaat tgttcatgcc gggcggcact atcgtcgtcc       60

ggccttttcc tctcttactc tgctacgtac atctatttct ataaatccgt tcaatttgtc      120

tgttttttgc acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa      180

tcagcaatat accccttaag gagtatataa aggtgaattt gatttacatc aataagcggg      240

gttgctgaat cgttaaggta ggcggtaata gaaaagaaat cgaggcaaaa                 290


<210> 571
<211> 433
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="nirB2 , FNR-responsive regulatory region"

<400> 571
cggcccgatc gttgaacata gcggtccgca ggcggcactg cttacagcaa acggtctgta       60

cgctgtcgtc tttgtgatgt gcttcctgtt aggtttcgtc agccgtcacc gtcagcataa      120

caccctgacc tctcattaat tgctcatgcc ggacggcact atcgtcgtcc ggccttttcc      180

tctcttcccc cgctacgtgc atctatttct ataaacccgc tcattttgtc tattttttgc      240

acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa tcagcaatat      300

acccattaag gagtatataa aggtgaattt gatttacatc aataagcggg gttgctgaat      360

cgttaaggta ggcggtaata gaaaagaaat cgaggcaaaa atgtttgttt aactttaaga      420

aggagatata cat                                                         433


<210> 572
<211> 290
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="nirB3 , FNR-responsive regulatory region"

<400> 572
gtcagcataa caccctgacc tctcattaat tgctcatgcc ggacggcact atcgtcgtcc       60

ggccttttcc tctcttcccc cgctacgtgc atctatttct ataaacccgc tcattttgtc      120

tattttttgc acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa      180

tcagcaatat acccattaag gagtatataa aggtgaattt gatttacatc aataagcggg      240

gttgctgaat cgttaaggta ggcggtaata gaaaagaaat cgaggcaaaa                 290


<210> 573
<211> 173
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="ydfZ , FNR-responsive regulatory region"

<400> 573
atttcctctc atcccatccg gggtgagagt cttttccccc gacttatggc tcatgcatgc       60

atcaaaaaag atgtgagctt gatcaaaaac aaaaaatatt tcactcgaca ggagtattta      120

tattgcgccc gttacgtggg cttcgactgt aaatcagaaa ggagaaaaca cct             173


<210> 574
<211> 305
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="nirB+RBS , FNR-responsive regulatory region"

<400> 574
gtcagcataa caccctgacc tctcattaat tgttcatgcc gggcggcact atcgtcgtcc       60

ggccttttcc tctcttactc tgctacgtac atctatttct ataaatccgt tcaatttgtc      120

tgttttttgc acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa      180

tcagcaatat accccttaag gagtatataa aggtgaattt gatttacatc aataagcggg      240

gttgctgaat cgttaaggat ccctctagaa ataattttgt ttaactttaa gaaggagata      300

tacat                                                                  305


<210> 575
<211> 180
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="ydfZ+RBS , FNR-responsive regulatory region"

<400> 575
catttcctct catcccatcc ggggtgagag tcttttcccc cgacttatgg ctcatgcatg       60

catcaaaaaa gatgtgagct tgatcaaaaa caaaaaatat ttcactcgac aggagtattt      120

atattgcgcc cggatccctc tagaaataat tttgtttaac tttaagaagg agatatacat      180


<210> 576
<211> 199
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FNRS1 , FNR-responsive regulatory region"

<400> 576
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgtaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctctt ggatccctct agaaataatt ttgtttaact      180

ttaagaagga gatatacat                                                   199


<210> 577
<211> 207
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FNRS2 , FNR-responsive regulatory region"

<400> 577
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgcaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctctt ggatccaaag tgaactctag aaataatttt      180

gtttaacttt aagaaggaga tatacat                                          207


<210> 578
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="nirB+crp , FNR-responsive regulatory region"

<400> 578
tcgtctttgt gatgtgcttc ctgttaggtt tcgtcagccg tcaccgtcag cataacaccc       60

tgacctctca ttaattgctc atgccggacg gcactatcgt cgtccggcct tttcctctct      120

tcccccgcta cgtgcatcta tttctataaa cccgctcatt ttgtctattt tttgcacaaa      180

catgaaatat cagacaattc cgtgacttaa gaaaatttat acaaatcagc aatataccca      240

ttaaggagta tataaaggtg aatttgattt acatcaataa gcggggttgc tgaatcgtta      300

aggtagaaat gtgatctagt tcacatttgc ggtaatagaa aagaaatcga ggcaaaaatg      360

tttgtttaac tttaagaagg agatatacat                                       390


<210> 579
<211> 200
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FNRS+crp , FNR-responsive regulatory region"

<400> 579
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgcaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctcaa atgtgatcta gttcacattt tttgtttaac      180

tttaagaagg agatatacat                                                  200


<210> 580
<211> 355
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="katG, Regulatory sequence"

<400> 580
tgtggctttt atgaaaatca cacagtgatc acaaatttta aacagagcac aaaatgctgc       60

ctcgaaatga gggcgggaaa ataaggttat cagccttgtt ttctccctca ttacttgaag      120

gatatgaagc taaaaccctt ttttataaag catttgtccg aattcggaca taatcaaaaa      180

agcttaatta agatcaattt gatctacatc tctttaacca acaatatgta agatctcaac      240

tatcgcatcc gtggattaat tcaattataa cttctctcta acgctgtgta tcgtaacggt      300

aacactgtag aggggagcac attgatgcga attcattaaa gaggagaaag gtacc           355


<210> 581
<211> 228
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Dps, Regulatory sequence"

<400> 581
ttccgaaaat tcctggcgag cagataaata agaattgttc ttatcaatat atctaactca       60

ttgaatcttt attagttttg tttttcacgc ttgttaccac tattagtgtg ataggaacag      120

ccagaatagc ggaacacata gccggtgcta tacttaatct cgttaattac tgggacataa      180

catcaagagg atatgaaatt cgaattcatt aaagaggaga aaggtacc                   228


<210> 582
<211> 334
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="ahpC, Regulatory sequence"

<400> 582
gcttagatca ggtgattgcc ctttgtttat gagggtgttg taatccatgt cgttgttgca       60

tttgtaaggg caacacctca gcctgcaggc aggcactgaa gataccaaag ggtagttcag      120

attacacggt cacctggaaa gggggccatt ttacttttta tcgccgctgg cggtgcaaag      180

ttcacaaagt tgtcttacga aggttgtaag gtaaaactta tcgatttgat aatggaaacg      240

cattagccga atcggcaaaa attggttacc ttacatctca tcgaaaacac ggaggaagta      300

tagatgcgaa ttcattaaag aggagaaagg tacc                                  334


<210> 583
<211> 134
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="oxyS Regulatory sequence"

<400> 583
ctcgagttca ttatccatcc tccatcgcca cgatagttca tggcgatagg tagaatagca       60

atgaacgatt atccctatca agcattctga ctgataattg ctcacacgaa ttcattaaag      120

aggagaaagg tacc                                                        134


<210> 584
<211> 1921
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Prp (Propionate)"

<400> 584
ttacccgtct ggattttcag tacgcgcttt taaacgacgc cacagcgtgg tacggctgat       60

ccccaaataa cgtgcggcgg cgcgcttatc gccattaaag cgtgcgagca cctcctgcaa      120

tggaagcgct tctgctgacg agggcgtgat ttctgctgtg gtccccacca gttcaggtaa      180

taattgccgc ataaattgtc tgtccagtgt tggtgcggga tcgacgctta aaaaaagcgc      240

caggcgttcc atcatattcc gcagttcgcg aatattaccg ggccaatgat agttcagtag      300

aagcggctga cactgcgtca gcccatgacg caccgattcg gtaaaaggga tctccatcgc      360

ggccagcgat tgttttaaaa agttttccgc cagaggcaga atatcaggct gtcgctcgcg      420

caagggggga agcggcagac gcagaatgct caaacggtaa aacagatcgg tacgaaaacg      480

tccttgcgtt atctcccgat ccagatcgca atgcgtggcg ctgatcaccc ggacatctac      540

cgggatcggc tgatgcccgc caacgcgggt gacggctttt tcctccagta cgcgtagaag      600

gcgggtttgt aacggcagcg gcatttcgcc aatttcgtca agaaacagcg tgccgccgtg      660

ggcgacctca aacagccccg cacgtccacc tcgtcttgag ccggtaaacg ctccctcctc      720

atagccaaac agttcagcct ccagcaacga ctcggtaatc gcgccgcaat taacggcgac      780

aaagggcgga gaaggcttgt tctgacggtg gggctgacgg ttaaacaacg cctgatgaat      840

cgcttgcgcc gccagctctt tcccggtccc tgtttccccc tgaatcagca ctgccgcgcg      900

ggaacgggca tagagtgtaa tcgtatggcg aacctgctcc atttgtggtg aatcgccgag      960

gatatcgctc agcgcataac gggtctgtaa tcccttgctg gaggtatgct ggctatactg     1020

acgccgtgtc aggcgggtca tatccagcgc atcatggaaa gcctgacgta cggtggccgc     1080

tgaataaata aagatggcgg tcattcctgc ctcttccgcc aggtcggtaa ttagtcctgc     1140

cccaattaca gcctcaatgc cgttagcttt gagctcgtta atttgcccgc gagcatcctc     1200

ttcagtgata tagcttcgct gttcaagacg gaggtgaaac gttttctgaa aggcgaccag     1260

agccggaatg gtctcctgat aggtcacgat tcccattgag gaagtcagct ttcccgcttt     1320

tgccagagcc tgtaatacat cgaatccgct gggtttgatg aggatgacag gtaccgacag     1380

tcggcttttt aaataagcgc cgttggaacc tgccgcgata atcgcgtcgc agcgttcggt     1440

tgccagtttt ttgcgaatgt aggctactgc cttttcaaaa ccgagctgaa taggcgtgat     1500

cgtcgccaga tgatcaaact ccaggctgat atcccgaaat agttcgaaca ggcgcgttac     1560

cgagaccgtc cagatcaccg gtttatcgct attatcgcgc gaagcgctat gcacagtaac     1620

catcgtcgta gattcatgtt taaggaacga attcttgttt tatagatgtt tcgttaatgt     1680

tgcaatgaaa cacaggcctc cgtttcatga aacgttagct gactcgtttt tcttgtgact     1740

cgtctgtcag tattaaaaaa gatttttcat ttaactgatt gtttttaaat tgaattttat     1800

ttaatggttt ctcggttttt gggtctggca tatcccttgc tttaatgagt gcatcttaat     1860

taacaattca ataacaagag ggctgaatag taatttcaac aaaataacga gcattcgaat     1920

g                                                                     1921


<210> 585
<211> 305
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Arabinose Promoter region"

<400> 585
cagacattgc cgtcactgcg tcttttactg gctcttctcg ctaacccaac cggtaacccc       60

gcttattaaa agcattctgt aacaaagcgg gaccaaagcc atgacaaaaa cgcgtaacaa      120

aagtgtctat aatcacggca gaaaagtcca cattgattat ttgcacggcg tcacactttg      180

ctatgccata gcatttttat ccataagatt agcggatcca gcctgacgct ttttttcgca      240

actctctact gtttctccat acctctagaa ataattttgt ttaactttaa gaaggagata      300

tacat                                                                  305


<210> 586
<211> 897
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="AraC (reverse orientation)"

<400> 586
ttattcacaa cctgccctaa actcgctcgg actcgccccg gtgcattttt taaatactcg       60

cgagaaatag agttgatcgt caaaaccgac attgcgaccg acggtggcga taggcatccg      120

ggtggtgctc aaaagcagct tcgcctgact gatgcgctgg tcctcgcgcc agcttaatac      180

gctaatccct aactgctggc ggaacaaatg cgacagacgc gacggcgaca ggcagacatg      240

ctgtgcgacg ctggcgatat caaaattact gtctgccagg tgatcgctga tgtactgaca      300

agcctcgcgt acccgattat ccatcggtgg atggagcgac tcgttaatcg cttccatgcg      360

ccgcagtaac aattgctcaa gcagatttat cgccagcaat tccgaatagc gcccttcccc      420

ttgtccggca ttaatgattt gcccaaacag gtcgctgaaa tgcggctggt gcgcttcatc      480

cgggcgaaag aaaccggtat tggcaaatat cgacggccag ttaagccatt catgccagta      540

ggcgcgcgga cgaaagtaaa cccactggtg ataccattcg tgagcctccg gatgacgacc      600

gtagtgatga atctctccag gcgggaacag caaaatatca cccggtcggc agacaaattc      660

tcgtccctga tttttcacca ccccctgacc gcgaatggtg agattgagaa tataaccttt      720

cattcccagc ggtcggtcga taaaaaaatc gagataaccg ttggcctcaa tcggcgttaa      780

acccgccacc agatgggcgt taaacgagta tcccggcagc aggggatcat tttgcgcttc      840

agccatactt ttcatactcc cgccattcag agaagaaacc aattgtccat attgcat         897


<210> 587
<211> 298
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="AraC polypeptide"

<400> 587
Met Gln Tyr Gly Gln Leu Val Ser Ser Leu Asn Gly Gly Ser Met Lys 
1               5                   10                  15      


Ser Met Ala Glu Ala Gln Asn Asp Pro Leu Leu Pro Gly Tyr Ser Phe 
            20                  25                  30          


Asn Ala His Leu Val Ala Gly Leu Thr Pro Ile Glu Ala Asn Gly Tyr 
        35                  40                  45              


Leu Asp Phe Phe Ile Asp Arg Pro Leu Gly Met Lys Gly Tyr Ile Leu 
    50                  55                  60                  


Asn Leu Thr Ile Arg Gly Gln Gly Val Val Lys Asn Gln Gly Arg Glu 
65                  70                  75                  80  


Phe Val Cys Arg Pro Gly Asp Ile Leu Leu Phe Pro Pro Gly Glu Ile 
                85                  90                  95      


His His Tyr Gly Arg His Pro Glu Ala His Glu Trp Tyr His Gln Trp 
            100                 105                 110         


Val Tyr Phe Arg Pro Arg Ala Tyr Trp His Glu Trp Leu Asn Trp Pro 
        115                 120                 125             


Ser Ile Phe Ala Asn Thr Gly Phe Phe Arg Pro Asp Glu Ala His Gln 
    130                 135                 140                 


Pro His Phe Ser Asp Leu Phe Gly Gln Ile Ile Asn Ala Gly Gln Gly 
145                 150                 155                 160 


Glu Gly Arg Tyr Ser Glu Leu Leu Ala Ile Asn Leu Leu Glu Gln Leu 
                165                 170                 175     


Leu Leu Arg Arg Met Glu Ala Ile Asn Glu Ser Leu His Pro Pro Met 
            180                 185                 190         


Asp Asn Arg Val Arg Glu Ala Cys Gln Tyr Ile Ser Asp His Leu Ala 
        195                 200                 205             


Asp Ser Asn Phe Asp Ile Ala Ser Val Ala Gln His Val Cys Leu Ser 
    210                 215                 220                 


Pro Ser Arg Leu Ser His Leu Phe Arg Gln Gln Leu Gly Ile Ser Val 
225                 230                 235                 240 


Leu Ser Trp Arg Glu Asp Gln Arg Ile Ser Gln Ala Lys Leu Leu Leu 
                245                 250                 255     


Ser Thr Thr Arg Met Pro Ile Ala Thr Val Gly Arg Asn Val Gly Phe 
            260                 265                 270         


Asp Asp Gln Leu Tyr Phe Ser Arg Val Phe Lys Lys Cys Thr Gly Ala 
        275                 280                 285             


Ser Pro Ser Glu Phe Arg Ala Gly Cys Glu 
    290                 295             


<210> 588
<211> 280
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Region comprising rhamnose inducible promoter"

<400> 588
cggtgagcat cacatcacca caattcagca aattgtgaac atcatcacgt tcatctttcc       60

ctggttgcca atggcccatt ttcctgtcag taacgagaag gtcgcgaatc aggcgctttt      120

tagactggtc gtaatgaaat tcagctgtca ccggatgtgc tttccggtct gatgagtccg      180

tgaggacgaa acagcctcta caaataattt tgtttaaaac aacacccact aagataactc      240

tagaaataat tttgtttaac tttaagaagg agatatacat                            280


<210> 589
<211> 326
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Lac Promoter region"

<400> 589
attcaccacc ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt       60

gcgccattcg atggcgcgcc gcttcgtcag gccacatagc tttcttgttc tgatcggaac      120

gatcgttggc tgtgttgaca attaatcatc ggctcgtata atgtgtggaa ttgtgagcgc      180

tcacaattag ctgtcaccgg atgtgctttc cggtctgatg agtccgtgag gacgaaacag      240

cctctacaaa taattttgtt taaaacaaca cccactaaga taactctaga aataattttg      300

tttaacttta agaaggagat atacat                                           326


<210> 590
<211> 1083
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="LacI (in reverse orientation)"

<400> 590
tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa       60

cgcgcgggga gaggcggttt gcgtattggg cgccagggtg gtttttcttt tcaccagtga      120

gactggcaac agctgattgc ccttcaccgc ctggccctga gagagttgca gcaagcggtc      180

cacgctggtt tgccccagca ggcgaaaatc ctgtttgatg gtggttaacg gcgggatata      240

acatgagcta tcttcggtat cgtcgtatcc cactaccgag atatccgcac caacgcgcag      300

cccggactcg gtaatggcgc gcattgcgcc cagcgccatc tgatcgttgg caaccagcat      360

cgcagtggga acgatgccct cattcagcat ttgcatggtt tgttgaaaac cggacatggc      420

actccagtcg ccttcccgtt ccgctatcgg ctgaatttga ttgcgagtga gatatttatg      480

ccagccagcc agacgcagac gcgccgagac agaacttaat gggcccgcta acagcgcgat      540

ttgctggtga cccaatgcga ccagatgctc cacgcccagt cgcgtaccgt cctcatggga      600

gaaaataata ctgttgatgg gtgtctggtc agagacatca agaaataacg ccggaacatt      660

agtgcaggca gcttccacag caatggcatc ctggtcatcc agcggatagt taatgatcag      720

cccactgacg cgttgcgcga gaagattgtg caccgccgct ttacaggctt cgacgccgct      780

tcgttctacc atcgacacca ccacgctggc acccagttga tcggcgcgag atttaatcgc      840

cgcgacaatt tgcgacggcg cgtgcagggc cagactggag gtggcaacgc caatcagcaa      900

cgactgtttg cccgccagtt gttgtgccac gcggttggga atgtaattca gctccgccat      960

cgccgcttcc actttttccc gcgttttcgc agaaacgtgg ctggcctggt tcaccacgcg     1020

ggaaacggtc tgataagaga caccggcata ctctgcgaca tcgtataacg ttactggttt     1080

cat                                                                   1083


<210> 591
<211> 360
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="LacI polypeptide sequence"

<400> 591
Met Lys Pro Val Thr Leu Tyr Asp Val Ala Glu Tyr Ala Gly Val Ser 
1               5                   10                  15      


Tyr Gln Thr Val Ser Arg Val Val Asn Gln Ala Ser His Val Ser Ala 
            20                  25                  30          


Lys Thr Arg Glu Lys Val Glu Ala Ala Met Ala Glu Leu Asn Tyr Ile 
        35                  40                  45              


Pro Asn Arg Val Ala Gln Gln Leu Ala Gly Lys Gln Ser Leu Leu Ile 
    50                  55                  60                  


Gly Val Ala Thr Ser Ser Leu Ala Leu His Ala Pro Ser Gln Ile Val 
65                  70                  75                  80  


Ala Ala Ile Lys Ser Arg Ala Asp Gln Leu Gly Ala Ser Val Val Val 
                85                  90                  95      


Ser Met Val Glu Arg Ser Gly Val Glu Ala Cys Lys Ala Ala Val His 
            100                 105                 110         


Asn Leu Leu Ala Gln Arg Val Ser Gly Leu Ile Ile Asn Tyr Pro Leu 
        115                 120                 125             


Asp Asp Gln Asp Ala Ile Ala Val Glu Ala Ala Cys Thr Asn Val Pro 
    130                 135                 140                 


Ala Leu Phe Leu Asp Val Ser Asp Gln Thr Pro Ile Asn Ser Ile Ile 
145                 150                 155                 160 


Phe Ser His Glu Asp Gly Thr Arg Leu Gly Val Glu His Leu Val Ala 
                165                 170                 175     


Leu Gly His Gln Gln Ile Ala Leu Leu Ala Gly Pro Leu Ser Ser Val 
            180                 185                 190         


Ser Ala Arg Leu Arg Leu Ala Gly Trp His Lys Tyr Leu Thr Arg Asn 
        195                 200                 205             


Gln Ile Gln Pro Ile Ala Glu Arg Glu Gly Asp Trp Ser Ala Met Ser 
    210                 215                 220                 


Gly Phe Gln Gln Thr Met Gln Met Leu Asn Glu Gly Ile Val Pro Thr 
225                 230                 235                 240 


Ala Met Leu Val Ala Asn Asp Gln Met Ala Leu Gly Ala Met Arg Ala 
                245                 250                 255     


Ile Thr Glu Ser Gly Leu Arg Val Gly Ala Asp Ile Ser Val Val Gly 
            260                 265                 270         


Tyr Asp Asp Thr Glu Asp Ser Ser Cys Tyr Ile Pro Pro Leu Thr Thr 
        275                 280                 285             


Ile Lys Gln Asp Phe Arg Leu Leu Gly Gln Thr Ser Val Asp Arg Leu 
    290                 295                 300                 


Leu Gln Leu Ser Gln Gly Gln Ala Val Lys Gly Asn Gln Leu Leu Pro 
305                 310                 315                 320 


Val Ser Leu Val Lys Arg Lys Thr Thr Leu Ala Pro Asn Thr Gln Thr 
                325                 330                 335     


Ala Ser Pro Arg Ala Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln 
            340                 345                 350         


Val Ser Arg Leu Glu Ser Gly Gln 
        355                 360 


<210> 592
<211> 222
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Region comprising Temperature sensitive promoter"

<400> 592
acgttaaatc tatcaccgca agggataaat atctaacacc gtgcgtgttg actattttac       60

ctctggcggt gataatggtt gcatagctgt caccggatgt gctttccggt ctgatgagtc      120

cgtgaggacg aaacagcctc tacaaataat tttgtttaaa acaacaccca ctaagataac      180

tctagaaata attttgttta actttaagaa ggagatatac at                         222


<210> 593
<211> 714
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="mutant cI857 repressor"

<400> 593
tcagccaaac gtctcttcag gccactgact agcgataact ttccccacaa cggaacaact       60

ctcattgcat gggatcattg ggtactgtgg gtttagtggt tgtaaaaaca cctgaccgct      120

atccctgatc agtttcttga aggtaaactc atcaccccca agtctggcta tgcagaaatc      180

acctggctca acagcctgct cagggtcaac gagaattaac attccgtcag gaaagcttgg      240

cttggagcct gttggtgcgg tcatggaatt accttcaacc tcaagccaga atgcagaatc      300

actggctttt ttggttgtgc ttacccatct ctccgcatca cctttggtaa aggttctaag      360

cttaggtgag aacatccctg cctgaacatg agaaaaaaca gggtactcat actcacttct      420

aagtgacggc tgcatactaa ccgcttcata catctcgtag atttctctgg cgattgaagg      480

gctaaattct tcaacgctaa ctttgagaat ttttgtaagc aatgcggcgt tataagcatt      540

taatgcattg atgccattaa ataaagcacc aacgcctgac tgccccatcc ccatcttgtc      600

tgcgacagat tcctgggata agccaagttc atttttcttt ttttcataaa ttgctttaag      660

gcgacgtgcg tcctcaagct gctcttgtgt taatggtttc ttttttgtgc tcat            714


<210> 594
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RBS and leader region"

<400> 594
ctctagaaat aattttgttt aactttaaga aggagatata cat                         43


<210> 595
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="mutant cI857 repressor polypeptide sequence"

<400> 595
Met Ser Thr Lys Lys Lys Pro Leu Thr Gln Glu Gln Leu Glu Asp Ala 
1               5                   10                  15      


Arg Arg Leu Lys Ala Ile Tyr Glu Lys Lys Lys Asn Glu Leu Gly Leu 
            20                  25                  30          


Ser Gln Glu Ser Val Ala Asp Lys Met Gly Met Gly Gln Ser Gly Val 
        35                  40                  45              


Gly Ala Leu Phe Asn Gly Ile Asn Ala Leu Asn Ala Tyr Asn Ala Ala 
    50                  55                  60                  


Leu Leu Thr Lys Ile Leu Lys Val Ser Val Glu Glu Phe Ser Pro Ser 
65                  70                  75                  80  


Ile Ala Arg Glu Ile Tyr Glu Met Tyr Glu Ala Val Ser Met Gln Pro 
                85                  90                  95      


Ser Leu Arg Ser Glu Tyr Glu Tyr Pro Val Phe Ser His Val Gln Ala 
            100                 105                 110         


Gly Met Phe Ser Pro Lys Leu Arg Thr Phe Thr Lys Gly Asp Ala Glu 
        115                 120                 125             


Arg Trp Val Ser Thr Thr Lys Lys Ala Ser Asp Ser Ala Phe Trp Leu 
    130                 135                 140                 


Glu Val Glu Gly Asn Ser Met Thr Ala Pro Thr Gly Ser Lys Pro Ser 
145                 150                 155                 160 


Phe Pro Asp Gly Met Leu Ile Leu Val Asp Pro Glu Gln Ala Val Glu 
                165                 170                 175     


Pro Gly Asp Phe Cys Ile Ala Arg Leu Gly Gly Asp Glu Phe Thr Phe 
            180                 185                 190         


Lys Lys Leu Ile Arg Asp Ser Gly Gln Val Phe Leu Gln Pro Leu Asn 
        195                 200                 205             


Pro Gln Tyr Pro Met Ile Pro Cys Asn Glu Ser Cys Ser Val Val Gly 
    210                 215                 220                 


Lys Val Ile Ala Ser Gln Trp Pro Glu Glu Thr Phe Gly 
225                 230                 235         


<210> 596
<211> 748
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="TetR-Tet promoter construct"

<400> 596
ttaagaccca ctttcacatt taagttgttt ttctaatccg catatgatca attcaaggcc       60

gaataagaag gctggctctg caccttggtg atcaaataat tcgatagctt gtcgtaataa      120

tggcggcata ctatcagtag taggtgtttc cctttcttct ttagcgactt gatgctcttg      180

atcttccaat acgcaaccta aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt      240

ctctagtgaa aaaccttgtt ggcataaaaa ggctaattga ttttcgagag tttcatactg      300

tttttctgta ggccgtgtac ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc      360

acatctaaaa cttttagcgt tattacgtaa aaaatcttgc cagctttccc cttctaaagg      420

gcaaaagtga gtatggtgcc tatctaacat ctcaatggct aaggcgtcga gcaaagcccg      480

cttatttttt acatgccaat acaatgtagg ctgctctaca cctagcttct gggcgagttt      540

acgggttgtt aaaccttcga ttccgacctc attaagcagc tctaatgcgc tgttaatcac      600

tttactttta tctaatctag acatcattaa ttcctaattt ttgttgacac tctatcattg      660

atagagttat tttaccactc cctatcagtg atagagaaaa gtgaactcta gaaataattt      720

tgtttaactt taagaaggag atatacat                                         748


<210> 597
<211> 225
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="PssB promoter"

<400> 597
tcacctttcc cggattaaac gcttttttgc ccggtggcat ggtgctaccg gcgatcacaa       60

acggttaatt atgacacaaa ttgacctgaa tgaatataca gtattggaat gcattacccg      120

gagtgttgtg taacaatgtc tggccaggtt tgtttcccgg aaccgaggtc acaacatagt      180

aaaagcgcta ttggtaatgg tacaatcgcg cgtttacact tattc                      225


<210> 598
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_I14018"

<400> 598
gtttatacat aggcgagtac tctgttatgg                                        30


<210> 599
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_I14033"

<400> 599
agaggttcca actttcacca taatgaaaca                                        30


<210> 600
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_I14034"

<400> 600
taaacaacta acggacaatt ctacctaaca                                        30


<210> 601
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_I732021"

<400> 601
acatcaagcc aaattaaaca ggattaacac                                        30


<210> 602
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_I742126"

<400> 602
gaggtaaaat agtcaacacg cacggtgtta                                        30


<210> 603
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J01006"

<400> 603
caggccggaa taactcccta taatgcgcca                                        30


<210> 604
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23100"

<400> 604
ggctagctca gtcctaggta cagtgctagc                                        30


<210> 605
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23101"

<400> 605
agctagctca gtcctaggta ttatgctagc                                        30


<210> 606
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23102"

<400> 606
agctagctca gtcctaggta ctgtgctagc                                        30


<210> 607
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23103"

<400> 607
agctagctca gtcctaggga ttatgctagc                                        30


<210> 608
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23104"

<400> 608
agctagctca gtcctaggta ttgtgctagc                                        30


<210> 609
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23105"

<400> 609
ggctagctca gtcctaggta ctatgctagc                                        30


<210> 610
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23106"

<400> 610
ggctagctca gtcctaggta tagtgctagc                                        30


<210> 611
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23107"

<400> 611
ggctagctca gccctaggta ttatgctagc                                        30


<210> 612
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23108"

<400> 612
agctagctca gtcctaggta taatgctagc                                        30


<210> 613
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23109"

<400> 613
agctagctca gtcctaggga ctgtgctagc                                        30


<210> 614
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23110"

<400> 614
ggctagctca gtcctaggta caatgctagc                                        30


<210> 615
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23111"

<400> 615
ggctagctca gtcctaggta tagtgctagc                                        30


<210> 616
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23112"

<400> 616
agctagctca gtcctaggga ttatgctagc                                        30


<210> 617
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23113"

<400> 617
ggctagctca gtcctaggga ttatgctagc                                        30


<210> 618
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23114"

<400> 618
ggctagctca gtcctaggta caatgctagc                                        30


<210> 619
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23115"

<400> 619
agctagctca gcccttggta caatgctagc                                        30


<210> 620
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23116"

<400> 620
agctagctca gtcctaggga ctatgctagc                                        30


<210> 621
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23117"

<400> 621
agctagctca gtcctaggga ttgtgctagc                                        30


<210> 622
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23118"

<400> 622
ggctagctca gtcctaggta ttgtgctagc                                        30


<210> 623
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23119"

<400> 623
agctagctca gtcctaggta taatgctagc                                        30


<210> 624
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23150"

<400> 624
ggctagctca gtcctaggta ttatgctagc                                        30


<210> 625
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J23151"

<400> 625
ggctagctca gtcctaggta caatgctagc                                        30


<210> 626
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J44002"

<400> 626
aaagtgtgac gccgtgcaaa taatcaatgt                                        30


<210> 627
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J48104"

<400> 627
gacgaatact taaaatcgtc atacttattt                                        30


<210> 628
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J54200"

<400> 628
aaacctttcg cggtatggca tgatagcgcc                                        30


<210> 629
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J56015"

<400> 629
tgatagcgcc cggaagagag tcaattcagg                                        30


<210> 630
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J64951"

<400> 630
ttatttaccg tgacgaacta attgctcgtg                                        30


<210> 631
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K088007"

<400> 631
catacgccgt tatacgttgt ttacgctttg                                        30


<210> 632
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K119000"

<400> 632
ttatgcttcc ggctcgtatg ttgtgtggac                                        30


<210> 633
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K119001"

<400> 633
ttatgcttcc ggctcgtatg gtgtgtggac                                        30


<210> 634
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1330002"

<400> 634
ggctagctca gtcctaggta ctatgctagc                                        30


<210> 635
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K137029"

<400> 635
atatatatat atatataatg gaagcgtttt                                        30


<210> 636
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K137030"

<400> 636
atatatatat atatataatg gaagcgtttt                                        30


<210> 637
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K137031"

<400> 637
ccccgaaagc ttaagaatat aattgtaagc                                        30


<210> 638
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K137032"

<400> 638
ccccgaaagc ttaagaatat aattgtaagc                                        30


<210> 639
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K137085"

<400> 639
tgacaatata tatatatata taatgctagc                                        30


<210> 640
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K137086"

<400> 640
acaatatata tatatatata taatgctagc                                        30


<210> 641
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K137087"

<400> 641
aatatatata tatatatata taatgctagc                                        30


<210> 642
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K137088"

<400> 642
tatatatata tatatatata taatgctagc                                        30


<210> 643
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K137089"

<400> 643
tatatatata tatatatata taatgctagc                                        30


<210> 644
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K137090"

<400> 644
aaaaaaaaaa aaaaaaaata taatgctagc                                        30


<210> 645
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K137091"

<400> 645
aaaaaaaaaa aaaaaaaata taatgctagc                                        30


<210> 646
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585100"

<400> 646
ggaattgtga gcggataaca atttcacaca                                        30


<210> 647
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585101"

<400> 647
ggaattgtga gcggataaca atttcacaca                                        30


<210> 648
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585102"

<400> 648
ggaattgtga gcggataaca atttcacaca                                        30


<210> 649
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585103"

<400> 649
ggaattgtga gcggataaca atttcacaca                                        30


<210> 650
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585104"

<400> 650
ggaattgtga gcggataaca atttcacaca                                        30


<210> 651
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585105"

<400> 651
ggaattgtga gcggataaca atttcacaca                                        30


<210> 652
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585106"

<400> 652
ggaattgtga gcggataaca atttcacaca                                        30


<210> 653
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585110"

<400> 653
ggaattgtga gcggataaca atttcacaca                                        30


<210> 654
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585113"

<400> 654
ggaattgtga gcggataaca atttcacaca                                        30


<210> 655
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585115"

<400> 655
ggaattgtga gcggataaca atttcacaca                                        30


<210> 656
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585116"

<400> 656
ggaattgtga gcggataaca atttcacaca                                        30


<210> 657
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585117"

<400> 657
ggaattgtga gcggataaca atttcacaca                                        30


<210> 658
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585118"

<400> 658
ggaattgtga gcggataaca atttcacaca                                        30


<210> 659
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1585119"

<400> 659
ggaattgtga gcggataaca atttcacaca                                        30


<210> 660
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1824896"

<400> 660
gattaaagag gagaaatact agagtactag                                        30


<210> 661
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K256002"

<400> 661
caccttcggg tgggcctttc tgcgtttata                                        30


<210> 662
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K256018"

<400> 662
caccttcggg tgggcctttc tgcgtttata                                        30


<210> 663
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K256020"

<400> 663
caccttcggg tgggcctttc tgcgtttata                                        30


<210> 664
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K256033"

<400> 664
caccttcggg tgggcctttc tgcgtttata                                        30


<210> 665
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K292000"

<400> 665
ggctagctca gtcctaggta cagtgctagc                                        30


<210> 666
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K292001"

<400> 666
tgctagctac tagagattaa agaggagaaa                                        30


<210> 667
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K418000"

<400> 667
ttgtgagcgg ataacaagat actgagcaca                                        30


<210> 668
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K418002"

<400> 668
ttgtgagcgg ataacaagat actgagcaca                                        30


<210> 669
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K418003"

<400> 669
ttgtgagcgg ataacaagat actgagcaca                                        30


<210> 670
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823004"

<400> 670
ggctagctca gtcctaggta cagtgctagc                                        30


<210> 671
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823005"

<400> 671
agctagctca gtcctaggta ttatgctagc                                        30


<210> 672
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823006"

<400> 672
agctagctca gtcctaggta ctgtgctagc                                        30


<210> 673
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823007"

<400> 673
agctagctca gtcctaggga ttatgctagc                                        30


<210> 674
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823008"

<400> 674
ggctagctca gtcctaggta tagtgctagc                                        30


<210> 675
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823010"

<400> 675
ggctagctca gtcctaggga ttatgctagc                                        30


<210> 676
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823011"

<400> 676
ggctagctca gtcctaggta caatgctagc                                        30


<210> 677
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823013"

<400> 677
agctagctca gtcctaggga ttgtgctagc                                        30


<210> 678
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823014"

<400> 678
ggctagctca gtcctaggta ttgtgctagc                                        30


<210> 679
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_M13101"

<400> 679
cctgttttta tgttattctc tctgtaaagg                                        30


<210> 680
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_M13102"

<400> 680
aaatatttgc ttatacaatc ttcctgtttt                                        30


<210> 681
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_M13103"

<400> 681
gctgataaac cgatacaatt aaaggctcct                                        30


<210> 682
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_M13104"

<400> 682
ctcttctcag cgtcttaatc taagctatcg                                        30


<210> 683
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_M13105"

<400> 683
atgagccagt tcttaaaatc gcataaggta                                        30


<210> 684
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_M13106"

<400> 684
ctattgattg tgacaaaata aacttattcc                                        30


<210> 685
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_M13108"

<400> 685
gtttcgcgct tggtataatc gctgggggtc                                        30


<210> 686
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_M13110"

<400> 686
ctttgcttct gactataata gtcagggtaa                                        30


<210> 687
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_M31519"

<400> 687
aaaccgatac aattaaaggc tcctgctagc                                        30


<210> 688
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_R1074"

<400> 688
caccacactg atagtgctag tgtagatcac                                        30


<210> 689
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_R1075"

<400> 689
gccggaataa ctccctataa tgcgccacca                                        30


<210> 690
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_S03331"

<400> 690
ttgacaagct tttcctcagc tccgtaaact                                        30


<210> 691
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J45992"

<400> 691
ggtttcaaaa ttgtgatcta tatttaacaa                                        30


<210> 692
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J45993"

<400> 692
ggtttcaaaa ttgtgatcta tatttaacaa                                        30


<210> 693
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J45504"

<400> 693
tctattccaa taaagaaatc ttcctgcgtg                                        30


<210> 694
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1895002"

<400> 694
gaccgaatat atagtggaaa cgtttagatg                                        30


<210> 695
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1895003"

<400> 695
ccacatcctg tttttaacct taaaatggca                                        30


<210> 696
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K143012"

<400> 696
aaaaatgggc tcgtgttgta caataaatgt                                        30


<210> 697
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K143013"

<400> 697
aaaaaaagcg cgcgattatg taaaatataa                                        30


<210> 698
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K780003"

<400> 698
aattgcagta ggcatgacaa aatggactca                                        30


<210> 699
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823000"

<400> 699
caagcttttc ctttataata gaatgaatga                                        30


<210> 700
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823002"

<400> 700
tctaagctag tgtattttgc gtttaatagt                                        30


<210> 701
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K823003"

<400> 701
aatgggctcg tgttgtacaa taaatgtagt                                        30


<210> 702
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K143010"

<400> 702
atccttatcg ttatgggtat tgtttgtaat                                        30


<210> 703
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K143011"

<400> 703
taaaagaatt gtgagcggga atacaacaac                                        30


<210> 704
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K143013"

<400> 704
aaaaaaagcg cgcgattatg taaaatataa                                        30


<210> 705
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K112706"

<400> 705
tacaaaataa ttcccctgca aacattatca                                        30


<210> 706
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K112707"

<400> 706
tacaaaataa ttcccctgca aacattatcg                                        30


<210> 707
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_I712074"

<400> 707
agggaataca agctacttgt tctttttgca                                        30


<210> 708
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_I719005"

<400> 708
taatacgact cactataggg aga                                               23


<210> 709
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J34814"

<400> 709
gaatttaata cgactcacta tagggaga                                          28


<210> 710
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J64997"

<400> 710
taatacgact cactatagg                                                    19


<210> 711
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K113010"

<400> 711
gagtcgtatt aatacgactc actatagggg                                        30


<210> 712
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K113011"

<400> 712
agtgagtcgt actacgactc actatagggg                                        30


<210> 713
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K113012"

<400> 713
gagtcgtatt aatacgactc tctatagggg                                        30


<210> 714
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K1614000"

<400> 714
taatacgact cactatag                                                     18


<210> 715
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_R0085"

<400> 715
taatacgact cactataggg aga                                               23


<210> 716
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_R0180"

<400> 716
ttatacgact cactataggg aga                                               23


<210> 717
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_R0181"

<400> 717
gaatacgact cactataggg aga                                               23


<210> 718
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_R0182"

<400> 718
taatacgtct cactataggg aga                                               23


<210> 719
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_R0183"

<400> 719
tcatacgact cactataggg aga                                               23


<210> 720
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_Z0251"

<400> 720
taatacgact cactataggg agaccacaac                                        30


<210> 721
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_Z0252"

<400> 721
taattgaact cactaaaggg agaccacagc                                        30


<210> 722
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_Z0253"

<400> 722
cgaagtaata cgactcacta ttagggaaga                                        30


<210> 723
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 723
atttaggtga cactataga                                                    19


<210> 724
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_I766555"

<400> 724
acaaacacaa atacacacac taaattaata                                        30


<210> 725
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_I766556"

<400> 725
ccaagcatac aatcaactat ctcatataca                                        30


<210> 726
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_I766557"

<400> 726
gatacaggat acagcggaaa caacttttaa                                        30


<210> 727
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J63005"

<400> 727
tttcaagcta taccaagcat acaatcaact                                        30


<210> 728
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K105027"

<400> 728
cctttgcagc ataaattact atacttctat                                        30


<210> 729
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K105028"

<400> 729
cctttgcagc ataaattact atacttctat                                        30


<210> 730
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K105029"

<400> 730
cctttgcagc ataaattact atacttctat                                        30


<210> 731
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K105030"

<400> 731
cctttgcagc ataaattact atacttctat                                        30


<210> 732
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K105031"

<400> 732
cctttgcagc ataaattact atacttctat                                        30


<210> 733
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K122000"

<400> 733
ttatctactt tttacaacaa atataaaaca                                        30


<210> 734
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K124000"

<400> 734
acaaacacaa atacacacac taaattaata                                        30


<210> 735
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K124002"

<400> 735
gtttcgaata aacacacata aacaaacaaa                                        30


<210> 736
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K319005"

<400> 736
ccaagcatac aatcaactat ctcatataca                                        30


<210> 737
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_M31201"

<400> 737
accatcaaag gaagctttaa tcttctcata                                        30


<210> 738
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_I712004"

<400> 738
agaacccact gcttactggc ttatcgaaat                                        30


<210> 739
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_K076017"

<400> 739
ggccgttttt ggcttttttg ttagacgaag                                        30


<210> 740
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Plpp"

<400> 740
ataagtgcct tcccatcaaa aaaatattct caacataaaa aactttgtgt aatacttgta       60

acgcta                                                                  66


<210> 741
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="PapFAB46"

<400> 741
aaaaagagta ttgacttcgc atctttttgt acctataata gattcattgc ta               52


<210> 742
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="PJ23101+UP element"

<400> 742
ggaaaatttt tttaaaaaaa aaactttaca gctagctcag tcctaggtat tatgctagc        59


<210> 743
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="PJ23107+UP element"

<400> 743
ggaaaatttt tttaaaaaaa aaactttacg gctagctcag ccctaggtat tatgctagc        59


<210> 744
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="PSYN23119"

<400> 744
ggaaaatttt tttaaaaaaa aaacttgaca gctagctcag tccttggtat aatgctagca       60

cgaa                                                                    64


<210> 745
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PhoA"

<400> 745
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala 
            20      


<210> 746
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PhoA"

<400> 746
Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Thr Lys Ala 
            20  


<210> 747
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="OmpF"

<400> 747
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala 
            20          


<210> 748
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="cvaC"

<400> 748
Met Arg Thr Leu Thr Leu Asn Glu Leu Asp Ser Val Ser Gly Gly 
1               5                   10                  15  


<210> 749
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="TorA"

<400> 749
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Thr Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Ala Gln Ala Ala 
        35                  40              


<210> 750
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="fdnG"

<400> 750
Met Asp Val Ser Arg Arg Gln Phe Phe Lys Ile Cys Ala Gly Gly Met 
1               5                   10                  15      


Ala Gly Thr Thr Val Ala Ala Leu Gly Phe Ala Pro Lys Gln Ala Leu 
            20                  25                  30          


Ala 
    


<210> 751
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="dmsA"

<400> 751
Met Lys Thr Lys Ile Pro Asp Ala Val Leu Ala Ala Glu Val Ser Arg 
1               5                   10                  15      


Arg Gly Leu Val Lys Thr Thr Ala Ile Gly Gly Leu Ala Met Ala Ser 
            20                  25                  30          


Ser Ala Leu Thr Leu Pro Phe Ser Arg Ile Ala His Ala 
        35                  40                  45  


<210> 752
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="PelB"

<400> 752
Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gln Pro Ala Met Ala 
            20      


<210> 753
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="HlyA secretion signal"

<400> 753
Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly 
1               5                   10                  15      


Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu Gln Leu 
            20                  25                  30          


Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu 
        35                  40                  45              


Thr Ala Ser Ala 
    50          


<210> 754
<211> 159
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="HlyA secretion signal"

<400> 754
cttaatccat taattaatga aatcagcaaa atcatttcag ctgcaggtaa ttttgatgtt       60

aaagaggaaa gagctgcagc ttctttattg cagttgtccg gtaatgccag tgatttttca      120

tatggacgga actcaataac tttgacagca tcagcataa                             159


<210> 755
<211> 355
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="VH (10D1)"

<400> 755
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc      300

tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210> 756
<211> 325
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="VL (10D1)"

<400> 756
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttggc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcattca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210> 757
<211> 355
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="VH (4B6)"

<400> 757
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaagcaa taaacactac      180

gcagactccg tgaagggccg attcaccgtc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc      300

tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210> 758
<211> 325
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="VL (4B6)"

<400> 758
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagcttct tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210> 759
<211> 358
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="VH (1E2)"

<400> 759
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt tttactgtgc gagagctccc      300

aattatattg gtgcttttga tgtctggggc caagggacaa tggtcaccgt ctcttcag        358


<210> 760
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="VL (1E2)"

<400> 760
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt accctccgac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210> 761
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Heavy chain (human monoclonal)"

<400> 761
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210> 762
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Light chain (human monoclonal)"

<400> 762
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 763
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Heavy chain (human monoclonal)"

<400> 763
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210> 764
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Light chain (human monoclonal)"

<400> 764
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210> 765
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv; Heavy Chain  linker  Light Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site
"

<400> 765
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
    130                 135                 140                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Tyr Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210> 766
<211> 1103
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv; Codon-optimized Heavy Chain  linker 
      Light Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site
"

<400> 766
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaaca aataaaaatg aggaggcaat tctaatgcaa      180

gtgcaactgg tagagtccgg tgggggcgtg gtgcagccgg gtcgcagcct gcgtctgtcg      240

tgcgcggcga gtggttttac gttttcgagt tatactatgc actgggttcg tcaagcgccg      300

ggcaaaggcc tggaatgggt tactttcatt tcttacgatg gtaataataa atattatgcg      360

gattctgtga aaggtcgctt tactatttcg cgcgataaca gtaaaaacac tctgtatctg      420

caaatgaatt ctctgcgtgc agaggatact gctatctatt actgcgcgcg tacgggctgg      480

ttgggcccgt ttgattattg gggccaaggc actttggtta ctgtgtcatc gggcgggggc      540

tctggcggtg gttcaggtgg tggcagtggt ggtggcgaga tcgtgttgac tcaatctccg      600

ggtactctgt ctctgtctcc gggtgaacgc gcgaccctgt cttgccgcgc ttctcagagt      660

gttggttcat cgtatctggc atggtatcaa cagaaaccgg gtcaagcgcc gcgtctgctg      720

atttacggtg cttttagtcg cgcaaccggg attccggatc gattttctgg ttcaggttct      780

ggcactgact ttactttgac tattagtcgt ctggaaccgg aggacttcgc ggtttattat      840

tgccaacagt atggttcttc tccgtggacc tttggtcaag gcactaaagt tgaaattaaa      900

taatcgccgt aacctgatta actgagactg acggcaacgc caaattgcct gatgcgctgc      960

gcttatcagg cctacaaggg gaattgcaat ttattgaatt tgcacatttt tgtaggccgg     1020

ataaggcgtt tacgccgcat ccggcaacat gaatggtaat ttgccagcaa cgtgcttccc     1080

cgccaacggc ggggtttttt ctg                                             1103


<210> 767
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv; Light Chain  linker  Heavy Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site
"

<400> 767
Met Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser 
                85                  90                  95      


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile Ser 
                165                 170                 175     


Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly 
    210                 215                 220                 


Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210> 768
<211> 1103
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv; Codon-optimized Light Chain  linker 
      Heavy Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site
"

<400> 768
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaaca gattataagg agttaaatag aaaaatggag      180

attgtactga cccagagccc tggtacattg tctttgtcgc ctggtgaacg cgcgactctg      240

tcttgtcgtg cgtctcagtc tgttggtagt tcgtatctgg cgtggtatca acaaaaaccg      300

ggccaagctc cgcgtctgct gatttacggt gcatttagcc gcgcgactgg cattccggac      360

cgcttttctg ggtctggctc aggtaccgat tttactctga ctatttcgcg tctggagccg      420

gaggatttcg cggtttatta ctgccagcaa tatggttcta gtccgtggac cttcggccaa      480

ggtactaaag tggaaatcaa aggcgggggt tcgggtggtg gctctggggg tggctcgggc      540

ggtgggcagg tgcaactggt tgagagtggt ggcggcgttg ttcaaccggg ccgctctctg      600

cgcctgtcgt gcgctgcttc tggctttacc tttagctctt atacgatgca ctgggttcgc      660

caagctccgg gtaaaggtct ggagtgggtg actttcattt cttacgatgg taacaacaaa      720

tattatgctg attctgttaa aggccgtttt actatttctc gagacaatag caaaaacact      780

ctgtacctgc agatgaattc tctgcgcgct gaagacaccg cgatttatta ttgtgcgcgc      840

actggttggc tgggtccgtt tgattattgg ggtcagggca cgctggttac tgttagctcg      900

tgatcgccgt aacctgatta actgagactg acggcaacgc caaattgcct gatgcgctgc      960

gcttatcagg cctacaaggg gaattgcaat ttattgaatt tgcacatttt tgtaggccgg     1020

ataaggcgtt tacgccgcat ccggcaacat gaatggtaat ttgccagcaa cgtgcttccc     1080

cgccaacggc ggggtttttt ctg                                             1103


<210> 769
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PD-1 scFv; Heavy Chain  linker  Light Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site
"

<400> 769
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn 
            20                  25                  30          


Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
    130                 135                 140                 


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
                165                 170                 175     


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
        195                 200                 205             


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro 
    210                 215                 220                 


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235     


<210> 770
<211> 1095
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PD-1 scFv; Codon-optimized Heavy Chain  linker  
      Light Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site
"

<400> 770
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaacc tcaaagaatt ataggaaagg aggaagcgat      180

aagtatgcag gtgcaattgg tggagtcggg tggcggcgtg gtgcaaccgg gtcgtagcct      240

gcgcctggat tgtaaagcgt caggcatcac gtttagcaat tctggcatgc actgggtgcg      300

tcaagcgccg ggcaaaggtc tggagtgggt tgcggtaatt tggtacgatg gttctaaacg      360

ctattacgcg gatagtgtga aaggtcgctt tactatctct cgcgataatt ctaaaaacac      420

cctgtttctg caaatgaatt cgttgcgtgc ggaagatact gcggtatatt attgtgctac      480

taacgatgat tattggggtc aaggcaccct ggtgactgtt tcgagcggcg gtggtagcgg      540

cggcggctct ggtggtggtt ctggtggcgg tgagattgtg ctgactcaaa gcccggcgac      600

cctgtctctg tcgccgggtg aacgcgctac tctgagttgc cgtgcgtcgc aaagcgtgtc      660

ttcttatctg gcgtggtacc aacaaaaacc gggtcaagcg ccgcgcctgc tgatatatga      720

tgctagtaat cgtgcaacgg gtattccggc acgcttttca ggttctggca gcggcaccga      780

tttcactctg actatctcgt cactggagcc ggaagacttt gcggtttatt attgtcagca      840

atcttctaat tggccgcgta cgtttggtca gggcactaaa gttgaaatca aataatcgcc      900

gtaacctgat taactgagac tgacggcaac gccaaattgc ctgatgcgct gcgcttatca      960

ggcctacaag gggaattgca atttattgaa tttgcacatt tttgtaggcc ggataaggcg     1020

tttacgccgc atccggcaac atgaatggta atttgccagc aacgtgcttc cccgccaacg     1080

gcggggtttt ttctg                                                      1095


<210> 771
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PD-1 scFv; Light Chain  linker  Heavy Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site
"

<400> 771
Met Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gln Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp 
    130                 135                 140                 


Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr 
                165                 170                 175     


Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235     


<210> 772
<211> 1085
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PD-1 scFv; Codon-optimized Light Chain  linker  
      Heavy Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site
"

<400> 772
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaaca tcaccaattt gaggaaaggt aaatatggaa      180

atcgttttaa cgcagtcgcc ggcgactctg tctttgtcgc ctggtgaacg tgctacgctg      240

tcttgccgcg cgtcacagtc tgtgtcgtca tatctggctt ggtaccaaca gaaaccgggc      300

caagctccgc gcctgctgat ttatgatgcg tctaatcgcg cgaccggcat tccggcgcgt      360

ttttctggct ccggctctgg caccgacttt actctgacta tttcgtctct ggaaccggaa      420

gattttgcgg tgtactattg ccagcaatct tctaattggc cgcgcacgtt tggtcaaggt      480

accaaggttg agatcaaagg tggtggctcg ggcggcggtt cgggcggcgg ctcaggtggt      540

ggccaagttc agttggttga gtctggcggg ggcgtagtac aaccgggtcg ttctttgcgt      600

ctggattgca aagcgagcgg tattaccttt agcaattcag gtatgcactg ggtgcgccaa      660

gcgccgggca aaggcctgga atgggttgcg gtgatttggt acgatggctc gaaacgttat      720

tatgctgaca gcgttaaagg tcgttttact attagccgtg ataattccaa aaatacgctg      780

tttctgcaga tgaatagcct gcgtgctgaa gacactgcgg tttattactg tgctactaat      840

gatgattact ggggccaggg caccctggtg actgtgagtt cttaatcgcc gtaacctgat      900

taactgagac tgacggcaac gccaaattgc ctgatgcgct gcgcttatca ggcctacaag      960

gggaattgca atttattgaa tttgcacatt tttgtaggcc ggataaggcg tttacgccgc     1020

atccggcaac atgaatggta atttgccagc aacgtgcttc cccgccaacg gcggggtttt     1080

ttctg                                                                 1085


<210> 773
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PDL-1 scFv; Heavy Chain  linker  Light Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site
"

<400> 773
Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp 
            20                  25                  30          


Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210> 774
<211> 1103
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PDL-1 scFv; Codon-optimized Heavy Chain  linker  
      Light Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site
"

<400> 774
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaact acataatttt ggggagggta ctcgatggaa      180

gttcagctgg tggagagtgg tggcggtctg gtgcagccgg gcggctctct gcgtctgagc      240

tgtgcggcgt ctggctttac gttttctgac agttggattc actgggtgcg ccaagcaccg      300

ggcaaaggcc tggagtgggt ggcgtggatt tctccgtatg gcggtagtac ttattatgct      360

gattctgtga aaggccgttt taccatttcg gcggacactt caaaaaatac cgcgtatctg      420

caaatgaata gcctgcgcgc tgaagacacg gctgtttact actgtgctcg ccgccactgg      480

ccgggcggtt tcgattattg gggccaaggc actctggtga ctgtgagctc tggcggcggg      540

tcgggtggcg gttctggcgg tggcagtggc ggtggtgata ttcaaatgac ccaatctccg      600

tcgtctctga gcgcgtctgt gggcgatcgt gtaaccatta cttgtcgtgc gtcgcaggat      660

gtgtctactg ctgtggcgtg gtatcagcaa aaaccgggta aagctccgaa actgctgatt      720

tatagcgctt cttttctgta tagtggtgtt ccgtcacgtt ttagcggttc aggctctggt      780

actgatttca cactgactat ttcttctctg caaccggaag atttcgcgac ttattattgt      840

cagcagtact tgtaccaccc ggcaactttt ggtcagggca ctaaagttga aattaaacgt      900

taatcgccgt aacctgatta actgagactg acggcaacgc caaattgcct gatgcgctgc      960

gcttatcagg cctacaaggg gaattgcaat ttattgaatt tgcacatttt tgtaggccgg     1020

ataaggcgtt tacgccgcat ccggcaacat gaatggtaat ttgccagcaa cgtgcttccc     1080

cgccaacggc ggggtttttt ctg                                             1103


<210> 775
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PDL-1 scFv; Light Chain  linker  Heavy Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site
"

<400> 775
Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr 
            20                  25                  30          


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro 
                85                  90                  95      


Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
                165                 170                 175     


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
    210                 215                 220                 


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210> 776
<211> 1103
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PDL-1 scFv; Codon-optimized Light Chain  linker  
      Heavy Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site
"

<400> 776
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaact ggcagacgcc taaggaggaa gaccatggat      180

attcagatga ctcagagccc tagctcactg tctgcgtcag ttggcgatcg tgtgactatt      240

acctgtcgcg ctagtcagga tgtgtctacg gcggttgcgt ggtatcaaca gaaaccgggc      300

aaagctccga aactgttgat ttattcagcg tctttcctgt attcgggtgt gccttctcgc      360

ttttcgggct ctggtagcgg tactgatttt acgctgacta ttagttcact gcaaccggag      420

gactttgcga cttattattg ccaacaatac ctgtatcacc cggcgacctt tggtcaaggc      480

actaaagtgg aaattaaacg cggcggcggc agcggtggcg gctctggtgg tgggtctggt      540

ggtggtgagg ttcagctggt tgagtctggt ggtggtctgg ttcaacctgg gggcagcctg      600

cgcctgtcgt gcgcggcgtc tggttttacg ttctcagatt cttggattca ctgggtacgt      660

caagctccgg gcaaaggtct ggagtgggtg gcgtggattt ctccgtatgg cggttcgacg      720

tattacgcgg actctgttaa agggcgtttt acgatctcag cggatacttc taaaaatact      780

gcgtatctgc aaatgaattc tctgcgagcg gaggataccg cggtgtatta ctgtgctcgc      840

cgccactggc ctggtggttt cgattattgg ggtcaaggta ccctggtgac tgtttcgtct      900

taatcgccgt aacctgatta actgagactg acggcaacgc caaattgcct gatgcgctgc      960

gcttatcagg cctacaaggg gaattgcaat ttattgaatt tgcacatttt tgtaggccgg     1020

ataaggcgtt tacgccgcat ccggcaacat gaatggtaat ttgccagcaa cgtgcttccc     1080

cgccaacggc ggggtttttt ctg                                             1103


<210> 777
<211> 606
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv"

<400> 777
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Gln Val Gln Leu Val 
    50                  55                  60                  


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
65                  70                  75                  80  


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His Trp Val 
                85                  90                  95      


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile Ser Tyr 
            100                 105                 110         


Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        115                 120                 125             


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    130                 135                 140                 


Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly Trp 
145                 150                 155                 160 


Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                165                 170                 175     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
        195                 200                 205             


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
    210                 215                 220                 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
225                 230                 235                 240 


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
                245                 250                 255     


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
            260                 265                 270         


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
        275                 280                 285             


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Phe Lys Ala Glu 
    290                 295                 300                 


Ala Asp Lys Ala Ala Ala Ala Lys Ala Asp Ser Phe Met Asn Ala Gly 
305                 310                 315                 320 


Tyr Lys Asn Phe Met Thr Glu Val Asn Asn Leu Asn Lys Arg Met Gly 
                325                 330                 335     


Asp Leu Arg Asp Thr Asn Gly Asp Ala Gly Ala Trp Ala Arg Ile Met 
            340                 345                 350         


Ser Gly Ala Gly Ser Ala Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His 
        355                 360                 365             


Val Gln Val Gly Phe Asp Lys Lys His Glu Leu Asp Gly Val Asp Leu 
    370                 375                 380                 


Phe Thr Gly Val Thr Met Thr Tyr Thr Asp Ser Ser Ala Asp Ser His 
385                 390                 395                 400 


Ala Phe Ser Gly Lys Thr Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser 
                405                 410                 415     


Ala Leu Phe Glu Ser Gly Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile 
            420                 425                 430         


His His Asp Asn Asp Tyr Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys 
        435                 440                 445             


His Tyr Asn Thr His Ser Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg 
    450                 455                 460                 


Tyr His Leu Thr Glu Glu Thr Phe Ile Glu Pro Gln Ala Glu Leu Val 
465                 470                 475                 480 


Tyr Gly Ala Val Ser Gly Lys Thr Phe Arg Trp Lys Asp Gly Asp Met 
                485                 490                 495     


Asp Leu Ser Met Lys Asn Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr 
            500                 505                 510         


Gly Ile Glu Leu Gly Lys Thr Phe Ser Gly Lys Asp Trp Ser Val Thr 
        515                 520                 525             


Ala Arg Ala Gly Thr Ser Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu 
    530                 535                 540                 


Thr Val Leu Arg Asp Ala Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys 
545                 550                 555                 560 


Asp Ser Arg Met Leu Phe Asn Val Gly Met Asn Ala Gln Ile Lys Asp 
                565                 570                 575     


Asn Met Arg Phe Gly Leu Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr 
            580                 585                 590         


Asn Val Asp Asn Ala Val Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600                 605     


<210> 778
<211> 2038
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv"

<400> 778
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcca      300

ggtacaatta gttgagagcg gcggcggtgt ggttcaaccg ggccgtagtc tgcgattgtc      360

ttgtgctgca tctggtttta ctttcagttc ttacacgatg cactgggttc gccaagctcc      420

gggcaaaggc ctggagtggg ttacctttat ttcttacgat ggcaataata agtattacgc      480

tgattctgtg aaaggtcgct ttactattag ccgagataac tctaaaaata ctctgtatct      540

gcaaatgaat tctctgcgtg cggaagatac tgcgatctat tattgtgcgc gtactggttg      600

gctgggcccg tttgattatt ggggccaagg cacgctggtt actgttagtt cgggcggcgg      660

ttctggtggc ggctctggtg gtggctctgg cggcggcgag attgtgctga ctcaatctcc      720

gggcacgctg tcactgtctc cgggtgaacg cgcgaccctg tcttgtcgcg cgagtcaaag      780

tgttggttct tcttatctgg cttggtatca gcaaaagcct ggtcaagcgc cgcgtctgtt      840

gatttatggc gcgttttcgc gcgcgactgg cattccggac cgattttctg gttctggttc      900

tggcactgat ttcactctga ccatttcacg cctggaaccg gaggattttg cggtgtacta      960

ttgccaacaa tatggctcat cgccgtggac gtttggccaa ggtactaaag ttgagattaa     1020

attcaaagcg gaggctgaca aggccgctgc agcaaaagct gactccttta tgaacgcggg     1080

ttacaaaaac ttcatgaccg aggtaaataa tctcaataaa cgtatgggtg atctgcgcga     1140

cactaatggg gatgcaggcg catgggcacg cattatgtct ggtgcaggtt cggcggatgg     1200

cgggtattct gacaattaca ctcatgttca ggtgggcttc gataaaaaac atgagctgga     1260

cggtgtggat ctgttcactg gcgtaaccat gacttatact gattcaagcg cagacagcca     1320

cgcattttca ggtaaaacga aatcagttgg cggcggtctg tatgcgagcg cactgttcga     1380

gagcggcgcc tacattgatc taattggcaa gtatattcac catgataatg attacacagg     1440

gaactttgca ggcctgggca ccaaacacta taacacgcat tcatggtacg ctggcgcaga     1500

aaccggctat agataccacc tgaccgagga aacctttatc gaaccgcaag cggaactggt     1560

ttacggtgcg gtcagtggca agacctttcg ttggaaagat ggtgatatgg atctgtcaat     1620

gaaaaaccgc gacttcagcc ccttgatcgg ccgcaccggc attgagctgg gcaaaacctt     1680

ctctggcaaa gattggtctg ttaccgcgcg tgcgggcact tcgtggcaat ttgatctgct     1740

aaacaacggt gagactgtac tgcgtgatgc gagtggcgaa aaacgtatta aaggtgaaaa     1800

agatagtaga atgctattca acgtgggcat gaatgcgcag atcaaagata acatgcgttt     1860

tgggttggag tttgaaaaat ccgcgttcgg taaatataat gttgacaatg ctgtgaacgc     1920

gaatttccgc tacatgtttt aactctaacg gacttgagtg aggttgtaaa gggagttggc     1980

tcctcggtac caaattccag aaaagaggcc tcccgaaagg ggggcctttt ttcgtttt       2038


<210> 779
<211> 606
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv"

<400> 779
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Glu Ile Val Leu Thr 
    50                  55                  60                  


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
65                  70                  75                  80  


Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr Leu Ala Trp Tyr 
                85                  90                  95      


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Phe 
            100                 105                 110         


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        115                 120                 125             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    130                 135                 140                 


Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Trp Thr Phe Gly Gln 
145                 150                 155                 160 


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            180                 185                 190         


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        195                 200                 205             


Phe Thr Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 
    210                 215                 220                 


Lys Gly Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys 
225                 230                 235                 240 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                245                 250                 255     


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            260                 265                 270         


Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp 
        275                 280                 285             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe Lys Ala Glu 
    290                 295                 300                 


Ala Asp Lys Ala Ala Ala Ala Lys Ala Asp Ser Phe Met Asn Ala Gly 
305                 310                 315                 320 


Tyr Lys Asn Phe Met Thr Glu Val Asn Asn Leu Asn Lys Arg Met Gly 
                325                 330                 335     


Asp Leu Arg Asp Thr Asn Gly Asp Ala Gly Ala Trp Ala Arg Ile Met 
            340                 345                 350         


Ser Gly Ala Gly Ser Ala Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His 
        355                 360                 365             


Val Gln Val Gly Phe Asp Lys Lys His Glu Leu Asp Gly Val Asp Leu 
    370                 375                 380                 


Phe Thr Gly Val Thr Met Thr Tyr Thr Asp Ser Ser Ala Asp Ser His 
385                 390                 395                 400 


Ala Phe Ser Gly Lys Thr Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser 
                405                 410                 415     


Ala Leu Phe Glu Ser Gly Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile 
            420                 425                 430         


His His Asp Asn Asp Tyr Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys 
        435                 440                 445             


His Tyr Asn Thr His Ser Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg 
    450                 455                 460                 


Tyr His Leu Thr Glu Glu Thr Phe Ile Glu Pro Gln Ala Glu Leu Val 
465                 470                 475                 480 


Tyr Gly Ala Val Ser Gly Lys Thr Phe Arg Trp Lys Asp Gly Asp Met 
                485                 490                 495     


Asp Leu Ser Met Lys Asn Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr 
            500                 505                 510         


Gly Ile Glu Leu Gly Lys Thr Phe Ser Gly Lys Asp Trp Ser Val Thr 
        515                 520                 525             


Ala Arg Ala Gly Thr Ser Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu 
    530                 535                 540                 


Thr Val Leu Arg Asp Ala Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys 
545                 550                 555                 560 


Asp Ser Arg Met Leu Phe Asn Val Gly Met Asn Ala Gln Ile Lys Asp 
                565                 570                 575     


Asn Met Arg Phe Gly Leu Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr 
            580                 585                 590         


Asn Val Asp Asn Ala Val Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600                 605     


<210> 780
<211> 2038
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv"

<400> 780
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcga      300

aattgtactg acccagtcgc ctggtaccct gtctctgtcg ccgggtgaac gtgctaccct      360

gtcttgtcgt gcttcgcaat cggttggctc gtcttatctg gcatggtatc agcaaaaacc      420

gggccaagcg cctcgtctgc tgatttatgg cgcgttttct cgtgctacgg gcattcctga      480

tcgtttttcg ggctctggct ctggtactga ttttacgctg actatcagcc gcttggaacc      540

tgaagatttt gcggtttatt attgccaaca atatggctct tctccgtgga cgtttggtca      600

aggcactaaa gttgaaatta aaggtggtgg ctcgggcggt ggttctggtg gtggtagtgg      660

tggtggtcaa gtgcagttgg ttgaatcggg tggcggtgtt gtgcagccgg gccgttcgtt      720

gcgtctgtct tgcgcagcga gtggtttcac cttctcttct tatactatgc actgggtgcg      780

tcaagcacct ggcaaaggtc tggagtgggt aacttttatt tcatacgatg gtaataataa      840

atattatgca gattctgtta aaggtcgctt tacgatttct cgcgataatt caaaaaatac      900

gctgtatctg cagatgaatt cgctgcgcgc tgaggatact gcgatctact attgtgcgcg      960

tactggttgg ctgggtccgt ttgattactg gggccaaggt acgctggtta cagtttcgtc     1020

gttcaaagcg gaggctgaca aggccgctgc agcaaaagct gactccttta tgaacgcggg     1080

ttacaaaaac ttcatgaccg aggtaaataa tctcaataaa cgtatgggtg atctgcgcga     1140

cactaatggg gatgcaggcg catgggcacg cattatgtct ggtgcaggtt cggcggatgg     1200

cgggtattct gacaattaca ctcatgttca ggtgggcttc gataaaaaac atgagctgga     1260

cggtgtggat ctgttcactg gcgtaaccat gacttatact gattcaagcg cagacagcca     1320

cgcattttca ggtaaaacga aatcagttgg cggcggtctg tatgcgagcg cactgttcga     1380

gagcggcgcc tacattgatc taattggcaa gtatattcac catgataatg attacacagg     1440

gaactttgca ggcctgggca ccaaacacta taacacgcat tcatggtacg ctggcgcaga     1500

aaccggctat agataccacc tgaccgagga aacctttatc gaaccgcaag cggaactggt     1560

ttacggtgcg gtcagtggca agacctttcg ttggaaagat ggtgatatgg atctgtcaat     1620

gaaaaaccgc gacttcagcc ccttgatcgg ccgcaccggc attgagctgg gcaaaacctt     1680

ctctggcaaa gattggtctg ttaccgcgcg tgcgggcact tcgtggcaat ttgatctgct     1740

aaacaacggt gagactgtac tgcgtgatgc gagtggcgaa aaacgtatta aaggtgaaaa     1800

agatagtaga atgctattca acgtgggcat gaatgcgcag atcaaagata acatgcgttt     1860

tgggttggag tttgaaaaat ccgcgttcgg taaatataat gttgacaatg ctgtgaacgc     1920

gaatttccgc tacatgtttt aactctaacg gacttgagtg aggttgtaaa gggagttggc     1980

tcctcggtac caaattccag aaaagaggcc tcccgaaagg ggggcctttt ttcgtttt       2038


<210> 781
<211> 600
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PD-1 scFv"

<400> 781
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Gln Val Gln Leu Val 
    50                  55                  60                  


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp 
65                  70                  75                  80  


Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val 
                85                  90                  95      


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr 
            100                 105                 110         


Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        115                 120                 125             


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser 
    130                 135                 140                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Glu Ile Val Leu Thr 
            180                 185                 190         


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
        195                 200                 205             


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
    210                 215                 220                 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
225                 230                 235                 240 


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                245                 250                 255     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
            260                 265                 270         


Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly 
        275                 280                 285             


Thr Lys Val Glu Ile Lys Phe Lys Ala Glu Ala Asp Lys Ala Ala Ala 
    290                 295                 300                 


Ala Lys Ala Asp Ser Phe Met Asn Ala Gly Tyr Lys Asn Phe Met Thr 
305                 310                 315                 320 


Glu Val Asn Asn Leu Asn Lys Arg Met Gly Asp Leu Arg Asp Thr Asn 
                325                 330                 335     


Gly Asp Ala Gly Ala Trp Ala Arg Ile Met Ser Gly Ala Gly Ser Ala 
            340                 345                 350         


Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His Val Gln Val Gly Phe Asp 
        355                 360                 365             


Lys Lys His Glu Leu Asp Gly Val Asp Leu Phe Thr Gly Val Thr Met 
    370                 375                 380                 


Thr Tyr Thr Asp Ser Ser Ala Asp Ser His Ala Phe Ser Gly Lys Thr 
385                 390                 395                 400 


Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser Ala Leu Phe Glu Ser Gly 
                405                 410                 415     


Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile His His Asp Asn Asp Tyr 
            420                 425                 430         


Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys His Tyr Asn Thr His Ser 
        435                 440                 445             


Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg Tyr His Leu Thr Glu Glu 
    450                 455                 460                 


Thr Phe Ile Glu Pro Gln Ala Glu Leu Val Tyr Gly Ala Val Ser Gly 
465                 470                 475                 480 


Lys Thr Phe Arg Trp Lys Asp Gly Asp Met Asp Leu Ser Met Lys Asn 
                485                 490                 495     


Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr Gly Ile Glu Leu Gly Lys 
            500                 505                 510         


Thr Phe Ser Gly Lys Asp Trp Ser Val Thr Ala Arg Ala Gly Thr Ser 
        515                 520                 525             


Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu Thr Val Leu Arg Asp Ala 
    530                 535                 540                 


Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys Asp Ser Arg Met Leu Phe 
545                 550                 555                 560 


Asn Val Gly Met Asn Ala Gln Ile Lys Asp Asn Met Arg Phe Gly Leu 
                565                 570                 575     


Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr Asn Val Asp Asn Ala Val 
            580                 585                 590         


Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600 


<210> 782
<211> 2020
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PD-1 scFv"

<400> 782
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcca      300

agtacaactg gttgaatccg gcggaggagt ggtgcaaccg ggccgcagtt tgcgtctgga      360

ttgtaaagct tcaggcatca ctttttctaa ttctggtatg cactgggttc gccaagctcc      420

gggtaaaggt ctggagtggg ttgcggtgat ctggtatgat ggttctaaac gatattatgc      480

ggatagtgtt aagggtcgtt ttactatttc tcgtgataat tctaagaaca ccttgtttct      540

gcagatgaat agtctgcgcg ctgaggatac tgcggtatat tattgtgcga ctaatgacga      600

ttattggggc caaggcacgc tggttaccgt gagctctggt ggtggttcgg gtggtggttc      660

tggtggtggg agcggcggtg gcgagatcgt tctgactcaa agcccggcga ctctgagtct      720

gagtccgggt gaacgtgcga ctctgagctg ccgtgcgtct cagagtgtgt cgagttatct      780

ggcgtggtac caacaaaaac cgggccaggc gccgcgactg ctgatttatg atgcttctaa      840

tcgtgcgact ggtattccgg cgcgctttag cggttctggc tcaggcactg acttcactct      900

gactatttct tcgctggaac cggaagattt tgcggtgtac tattgtcaac aatcatctaa      960

ttggcctcgt acgttcggtc aaggtacaaa agtggagata aaattcaaag cggaggctga     1020

caaggccgct gcagcaaaag ctgactcctt tatgaacgcg ggttacaaaa acttcatgac     1080

cgaggtaaat aatctcaata aacgtatggg tgatctgcgc gacactaatg gggatgcagg     1140

cgcatgggca cgcattatgt ctggtgcagg ttcggcggat ggcgggtatt ctgacaatta     1200

cactcatgtt caggtgggct tcgataaaaa acatgagctg gacggtgtgg atctgttcac     1260

tggcgtaacc atgacttata ctgattcaag cgcagacagc cacgcatttt caggtaaaac     1320

gaaatcagtt ggcggcggtc tgtatgcgag cgcactgttc gagagcggcg cctacattga     1380

tctaattggc aagtatattc accatgataa tgattacaca gggaactttg caggcctggg     1440

caccaaacac tataacacgc attcatggta cgctggcgca gaaaccggct atagatacca     1500

cctgaccgag gaaaccttta tcgaaccgca agcggaactg gtttacggtg cggtcagtgg     1560

caagaccttt cgttggaaag atggtgatat ggatctgtca atgaaaaacc gcgacttcag     1620

ccccttgatc ggccgcaccg gcattgagct gggcaaaacc ttctctggca aagattggtc     1680

tgttaccgcg cgtgcgggca cttcgtggca atttgatctg ctaaacaacg gtgagactgt     1740

actgcgtgat gcgagtggcg aaaaacgtat taaaggtgaa aaagatagta gaatgctatt     1800

caacgtgggc atgaatgcgc agatcaaaga taacatgcgt tttgggttgg agtttgaaaa     1860

atccgcgttc ggtaaatata atgttgacaa tgctgtgaac gcgaatttcc gctacatgtt     1920

ttaactctaa cggacttgag tgaggttgta aagggagttg gctcctcggt accaaattcc     1980

agaaaagagg cctcccgaaa ggggggcctt ttttcgtttt                           2020


<210> 783
<211> 600
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PD-1 scFv"

<400> 783
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Glu Ile Val Leu Thr 
    50                  55                  60                  


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
65                  70                  75                  80  


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
                85                  90                  95      


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
            100                 105                 110         


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        115                 120                 125             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    130                 135                 140                 


Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly 
145                 150                 155                 160 


Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            180                 185                 190         


Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile 
        195                 200                 205             


Thr Phe Ser Asn Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr 
225                 230                 235                 240 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                245                 250                 255     


Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            260                 265                 270         


Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr 
        275                 280                 285             


Leu Val Thr Val Ser Ser Phe Lys Ala Glu Ala Asp Lys Ala Ala Ala 
    290                 295                 300                 


Ala Lys Ala Asp Ser Phe Met Asn Ala Gly Tyr Lys Asn Phe Met Thr 
305                 310                 315                 320 


Glu Val Asn Asn Leu Asn Lys Arg Met Gly Asp Leu Arg Asp Thr Asn 
                325                 330                 335     


Gly Asp Ala Gly Ala Trp Ala Arg Ile Met Ser Gly Ala Gly Ser Ala 
            340                 345                 350         


Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His Val Gln Val Gly Phe Asp 
        355                 360                 365             


Lys Lys His Glu Leu Asp Gly Val Asp Leu Phe Thr Gly Val Thr Met 
    370                 375                 380                 


Thr Tyr Thr Asp Ser Ser Ala Asp Ser His Ala Phe Ser Gly Lys Thr 
385                 390                 395                 400 


Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser Ala Leu Phe Glu Ser Gly 
                405                 410                 415     


Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile His His Asp Asn Asp Tyr 
            420                 425                 430         


Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys His Tyr Asn Thr His Ser 
        435                 440                 445             


Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg Tyr His Leu Thr Glu Glu 
    450                 455                 460                 


Thr Phe Ile Glu Pro Gln Ala Glu Leu Val Tyr Gly Ala Val Ser Gly 
465                 470                 475                 480 


Lys Thr Phe Arg Trp Lys Asp Gly Asp Met Asp Leu Ser Met Lys Asn 
                485                 490                 495     


Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr Gly Ile Glu Leu Gly Lys 
            500                 505                 510         


Thr Phe Ser Gly Lys Asp Trp Ser Val Thr Ala Arg Ala Gly Thr Ser 
        515                 520                 525             


Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu Thr Val Leu Arg Asp Ala 
    530                 535                 540                 


Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys Asp Ser Arg Met Leu Phe 
545                 550                 555                 560 


Asn Val Gly Met Asn Ala Gln Ile Lys Asp Asn Met Arg Phe Gly Leu 
                565                 570                 575     


Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr Asn Val Asp Asn Ala Val 
            580                 585                 590         


Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600 


<210> 784
<211> 2020
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PD-1 scFv"

<400> 784
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcga      300

aatcgtgctg actcagagtc cggcgactct gtctctgagt ccgggcgaac gcgcgactct      360

gtcttgccgt gcgtctcaat ctgtgtcttc atacttggct tggtaccaac aaaaaccggg      420

ccaggcgccg cgactgttga tttatgatgc gtcgaatcgc gcgactggca ttccggcgcg      480

cttttcgggt agcggttctg gtactgattt tacgctgact atctcttctc tggagcctga      540

agatttcgct gtttattact gccaacagtc tagtaattgg ccgcgtactt tcggccaggg      600

cactaaggtg gaaattaaag gtggcggctc gggcggcggc tcgggtggtg gttctggtgg      660

tggccaagtg caactggtgg aaagtggcgg cggggtggtg caaccgggcc gttctctgcg      720

cctggattgt aaagcttcag gcattacttt tagcaactct ggtatgcact gggttcgcca      780

agctccgggc aaaggcctgg aatgggtggc ggttatttgg tacgatggct ctaaacgtta      840

ttacgctgac agtgttaaag gccgctttac catttctcgt gataattcta aaaataccct      900

gtttctgcaa atgaactcgc tgcgcgcgga agatactgct gtttactatt gtgcgactaa      960

tgatgattac tggggtcaag gtaccctggt taccgtgtct tctttcaaag cggaggctga     1020

caaggccgct gcagcaaaag ctgactcctt tatgaacgcg ggttacaaaa acttcatgac     1080

cgaggtaaat aatctcaata aacgtatggg tgatctgcgc gacactaatg gggatgcagg     1140

cgcatgggca cgcattatgt ctggtgcagg ttcggcggat ggcgggtatt ctgacaatta     1200

cactcatgtt caggtgggct tcgataaaaa acatgagctg gacggtgtgg atctgttcac     1260

tggcgtaacc atgacttata ctgattcaag cgcagacagc cacgcatttt caggtaaaac     1320

gaaatcagtt ggcggcggtc tgtatgcgag cgcactgttc gagagcggcg cctacattga     1380

tctaattggc aagtatattc accatgataa tgattacaca gggaactttg caggcctggg     1440

caccaaacac tataacacgc attcatggta cgctggcgca gaaaccggct atagatacca     1500

cctgaccgag gaaaccttta tcgaaccgca agcggaactg gtttacggtg cggtcagtgg     1560

caagaccttt cgttggaaag atggtgatat ggatctgtca atgaaaaacc gcgacttcag     1620

ccccttgatc ggccgcaccg gcattgagct gggcaaaacc ttctctggca aagattggtc     1680

tgttaccgcg cgtgcgggca cttcgtggca atttgatctg ctaaacaacg gtgagactgt     1740

actgcgtgat gcgagtggcg aaaaacgtat taaaggtgaa aaagatagta gaatgctatt     1800

caacgtgggc atgaatgcgc agatcaaaga taacatgcgt tttgggttgg agtttgaaaa     1860

atccgcgttc ggtaaatata atgttgacaa tgctgtgaac gcgaatttcc gctacatgtt     1920

ttaactctaa cggacttgag tgaggttgta aagggagttg gctcctcggt accaaattcc     1980

agaaaagagg cctcccgaaa ggggggcctt ttttcgtttt                           2020


<210> 785
<211> 606
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PDL-1 scFv"

<400> 785
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Asp Ile Gln Met Thr 
    50                  55                  60                  


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
65                  70                  75                  80  


Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln 
                85                  90                  95      


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
            100                 105                 110         


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        115                 120                 125             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    130                 135                 140                 


Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly 
145                 150                 155                 160 


Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            180                 185                 190         


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        195                 200                 205             


Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly 
    210                 215                 220                 


Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr 
225                 230                 235                 240 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                245                 250                 255     


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            260                 265                 270         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp Pro Gly Gly Phe Asp 
        275                 280                 285             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe Lys Ala Glu 
    290                 295                 300                 


Ala Asp Lys Ala Ala Ala Ala Lys Ala Asp Ser Phe Met Asn Ala Gly 
305                 310                 315                 320 


Tyr Lys Asn Phe Met Thr Glu Val Asn Asn Leu Asn Lys Arg Met Gly 
                325                 330                 335     


Asp Leu Arg Asp Thr Asn Gly Asp Ala Gly Ala Trp Ala Arg Ile Met 
            340                 345                 350         


Ser Gly Ala Gly Ser Ala Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His 
        355                 360                 365             


Val Gln Val Gly Phe Asp Lys Lys His Glu Leu Asp Gly Val Asp Leu 
    370                 375                 380                 


Phe Thr Gly Val Thr Met Thr Tyr Thr Asp Ser Ser Ala Asp Ser His 
385                 390                 395                 400 


Ala Phe Ser Gly Lys Thr Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser 
                405                 410                 415     


Ala Leu Phe Glu Ser Gly Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile 
            420                 425                 430         


His His Asp Asn Asp Tyr Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys 
        435                 440                 445             


His Tyr Asn Thr His Ser Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg 
    450                 455                 460                 


Tyr His Leu Thr Glu Glu Thr Phe Ile Glu Pro Gln Ala Glu Leu Val 
465                 470                 475                 480 


Tyr Gly Ala Val Ser Gly Lys Thr Phe Arg Trp Lys Asp Gly Asp Met 
                485                 490                 495     


Asp Leu Ser Met Lys Asn Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr 
            500                 505                 510         


Gly Ile Glu Leu Gly Lys Thr Phe Ser Gly Lys Asp Trp Ser Val Thr 
        515                 520                 525             


Ala Arg Ala Gly Thr Ser Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu 
    530                 535                 540                 


Thr Val Leu Arg Asp Ala Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys 
545                 550                 555                 560 


Asp Ser Arg Met Leu Phe Asn Val Gly Met Asn Ala Gln Ile Lys Asp 
                565                 570                 575     


Asn Met Arg Phe Gly Leu Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr 
            580                 585                 590         


Asn Val Asp Asn Ala Val Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600                 605     


<210> 786
<211> 2038
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PDL-1 scFv"

<400> 786
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcga      300

agtgcagctg gtggagtcag gtggaggctt ggtgcaaccg ggcggttcac tgcgtctgtc      360

atgtgcggcg tctgggttta cttttagtga ctcttggatt cactgggtgc gccaggctcc      420

gggtaaaggc ctggaatggg tagcttggat tagtccttac ggtggctcga cctattatgc      480

tgattcggta aagggtcgct ttactattag cgctgatact tctaaaaata ctgcatacct      540

gcagatgaat agcctgcgcg ctgaggatac tgctgtgtat tattgcgcgc gtcgccactg      600

gccgggcggc tttgattatt ggggccaagg tactctggtt accgtgtcta gtggcggtgg      660

tagcggcggc ggctcaggtg gcggctcggg cggtggcgac attcagatga ctcagtctcc      720

gtcttctttg tcggcgagcg tgggcgatcg tgttaccatc acgtgtcgcg cgagccaaga      780

tgtgtcgact gcggtggctt ggtatcaaca aaaaccgggt aaagctccga aactgctgat      840

ttatagtgcg tcttttttgt attctggtgt tccgtctcgt ttctctggct caggtagcgg      900

tactgatttt acgctgacta tttcttcact gcaaccggaa gattttgcta cgtattattg      960

tcaacaatat ctgtatcacc cggcgacgtt tggtcagggt actaaggtgg agataaaacg     1020

cttcaaagcg gaggctgaca aggccgctgc agcaaaagct gactccttta tgaacgcggg     1080

ttacaaaaac ttcatgaccg aggtaaataa tctcaataaa cgtatgggtg atctgcgcga     1140

cactaatggg gatgcaggcg catgggcacg cattatgtct ggtgcaggtt cggcggatgg     1200

cgggtattct gacaattaca ctcatgttca ggtgggcttc gataaaaaac atgagctgga     1260

cggtgtggat ctgttcactg gcgtaaccat gacttatact gattcaagcg cagacagcca     1320

cgcattttca ggtaaaacga aatcagttgg cggcggtctg tatgcgagcg cactgttcga     1380

gagcggcgcc tacattgatc taattggcaa gtatattcac catgataatg attacacagg     1440

gaactttgca ggcctgggca ccaaacacta taacacgcat tcatggtacg ctggcgcaga     1500

aaccggctat agataccacc tgaccgagga aacctttatc gaaccgcaag cggaactggt     1560

ttacggtgcg gtcagtggca agacctttcg ttggaaagat ggtgatatgg atctgtcaat     1620

gaaaaaccgc gacttcagcc ccttgatcgg ccgcaccggc attgagctgg gcaaaacctt     1680

ctctggcaaa gattggtctg ttaccgcgcg tgcgggcact tcgtggcaat ttgatctgct     1740

aaacaacggt gagactgtac tgcgtgatgc gagtggcgaa aaacgtatta aaggtgaaaa     1800

agatagtaga atgctattca acgtgggcat gaatgcgcag atcaaagata acatgcgttt     1860

tgggttggag tttgaaaaat ccgcgttcgg taaatataat gttgacaatg ctgtgaacgc     1920

gaatttccgc tacatgtttt aactctaacg gacttgagtg aggttgtaaa gggagttggc     1980

tcctcggtac caaattccag aaaagaggcc tcccgaaagg ggggcctttt ttcgtttt       2038


<210> 787
<211> 600
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PDL-1 scFv"

<400> 787
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Glu Ile Val Leu Thr 
    50                  55                  60                  


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
65                  70                  75                  80  


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
                85                  90                  95      


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
            100                 105                 110         


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        115                 120                 125             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    130                 135                 140                 


Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly 
145                 150                 155                 160 


Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            180                 185                 190         


Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile 
        195                 200                 205             


Thr Phe Ser Asn Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr 
225                 230                 235                 240 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                245                 250                 255     


Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            260                 265                 270         


Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr 
        275                 280                 285             


Leu Val Thr Val Ser Ser Phe Lys Ala Glu Ala Asp Lys Ala Ala Ala 
    290                 295                 300                 


Ala Lys Ala Asp Ser Phe Met Asn Ala Gly Tyr Lys Asn Phe Met Thr 
305                 310                 315                 320 


Glu Val Asn Asn Leu Asn Lys Arg Met Gly Asp Leu Arg Asp Thr Asn 
                325                 330                 335     


Gly Asp Ala Gly Ala Trp Ala Arg Ile Met Ser Gly Ala Gly Ser Ala 
            340                 345                 350         


Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His Val Gln Val Gly Phe Asp 
        355                 360                 365             


Lys Lys His Glu Leu Asp Gly Val Asp Leu Phe Thr Gly Val Thr Met 
    370                 375                 380                 


Thr Tyr Thr Asp Ser Ser Ala Asp Ser His Ala Phe Ser Gly Lys Thr 
385                 390                 395                 400 


Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser Ala Leu Phe Glu Ser Gly 
                405                 410                 415     


Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile His His Asp Asn Asp Tyr 
            420                 425                 430         


Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys His Tyr Asn Thr His Ser 
        435                 440                 445             


Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg Tyr His Leu Thr Glu Glu 
    450                 455                 460                 


Thr Phe Ile Glu Pro Gln Ala Glu Leu Val Tyr Gly Ala Val Ser Gly 
465                 470                 475                 480 


Lys Thr Phe Arg Trp Lys Asp Gly Asp Met Asp Leu Ser Met Lys Asn 
                485                 490                 495     


Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr Gly Ile Glu Leu Gly Lys 
            500                 505                 510         


Thr Phe Ser Gly Lys Asp Trp Ser Val Thr Ala Arg Ala Gly Thr Ser 
        515                 520                 525             


Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu Thr Val Leu Arg Asp Ala 
    530                 535                 540                 


Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys Asp Ser Arg Met Leu Phe 
545                 550                 555                 560 


Asn Val Gly Met Asn Ala Gln Ile Lys Asp Asn Met Arg Phe Gly Leu 
                565                 570                 575     


Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr Asn Val Asp Asn Ala Val 
            580                 585                 590         


Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600 


<210> 788
<211> 2038
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PDL-1 scFv"

<400> 788
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcga      300

tattcaaatg actcaatctc cgagctctct gagtgcgtct gtgggtgatc gtgtgactat      360

tacttgtcgt gcgtctcaag atgtttcaac tgcggttgcg tggtatcaac agaaaccggg      420

caaggcgcct aagctgctga tttattctgc ttcgttcctg tacagcggtg tgccgtctcg      480

tttctctggc tctggttcgg gtactgattt cactctgact atttcgagtc tgcagccgga      540

agattttgcg acttattatt gtcaacaata tctgtatcac cctgcgacgt ttggtcaagg      600

cacgaaagtt gaaattaaac gtggtggtgg ctctggtggt ggcagcggtg gtgggtcggg      660

tggcggtgaa gttcaactgg ttgagtcagg tggtggcctg gtgcaaccgg gcggctctct      720

gcgcctgtct tgtgctgcgt cgggttttac gttctctgat agctggattc actgggtacg      780

ccaggcaccg ggcaaaggtc tggaatgggt agcttggatt tcaccttatg gtggctctac      840

ttattacgcg gatagcgtga aaggtcgctt tactatttct gcggacacta gcaaaaatac      900

tgcttacctg caaatgaatt cgctgcgtgc tgaggatact gcagtgtatt actgtgcgcg      960

tcgtcattgg cctggcggct ttgattattg gggtcaaggt actctggtta ctgttagcag     1020

cttcaaagcg gaggctgaca aggccgctgc agcaaaagct gactccttta tgaacgcggg     1080

ttacaaaaac ttcatgaccg aggtaaataa tctcaataaa cgtatgggtg atctgcgcga     1140

cactaatggg gatgcaggcg catgggcacg cattatgtct ggtgcaggtt cggcggatgg     1200

cgggtattct gacaattaca ctcatgttca ggtgggcttc gataaaaaac atgagctgga     1260

cggtgtggat ctgttcactg gcgtaaccat gacttatact gattcaagcg cagacagcca     1320

cgcattttca ggtaaaacga aatcagttgg cggcggtctg tatgcgagcg cactgttcga     1380

gagcggcgcc tacattgatc taattggcaa gtatattcac catgataatg attacacagg     1440

gaactttgca ggcctgggca ccaaacacta taacacgcat tcatggtacg ctggcgcaga     1500

aaccggctat agataccacc tgaccgagga aacctttatc gaaccgcaag cggaactggt     1560

ttacggtgcg gtcagtggca agacctttcg ttggaaagat ggtgatatgg atctgtcaat     1620

gaaaaaccgc gacttcagcc ccttgatcgg ccgcaccggc attgagctgg gcaaaacctt     1680

ctctggcaaa gattggtctg ttaccgcgcg tgcgggcact tcgtggcaat ttgatctgct     1740

aaacaacggt gagactgtac tgcgtgatgc gagtggcgaa aaacgtatta aaggtgaaaa     1800

agatagtaga atgctattca acgtgggcat gaatgcgcag atcaaagata acatgcgttt     1860

tgggttggag tttgaaaaat ccgcgttcgg taaatataat gttgacaatg ctgtgaacgc     1920

gaatttccgc tacatgtttt aactctaacg gacttgagtg aggttgtaaa gggagttggc     1980

tcctcggtac caaattccag aaaagaggcc tcccgaaagg ggggcctttt ttcgtttt       2038


<210> 789
<211> 294
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv"

<400> 789
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
    130                 135                 140                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Tyr Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala 
                245                 250                 255     


Ala Gly Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu 
            260                 265                 270         


Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile 
        275                 280                 285             


Thr Leu Thr Ala Ser Ala 
    290                 


<210> 790
<211> 5309
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv"

<400> 790
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aatacgattt      720

aattcggagg ttttttgatg caggtacaat tagttgagag cggcggcggt gtggttcaac      780

cgggccgtag tctgcgattg tcttgtgctg catctggttt tactttcagt tcttacacga      840

tgcactgggt tcgccaagct ccgggcaaag gcctggagtg ggttaccttt atttcttacg      900

atggcaataa taagtattac gctgattctg tgaaaggtcg ctttactatt agccgagata      960

actctaaaaa tactctgtat ctgcaaatga attctctgcg tgcggaagat actgcgatct     1020

attattgtgc gcgtactggt tggctgggcc cgtttgatta ttggggccaa ggcacgctgg     1080

ttactgttag ttcgggcggc ggttctggtg gcggctctgg tggtggctct ggcggcggcg     1140

agattgtgct gactcaatct ccgggcacgc tgtcactgtc tccgggtgaa cgcgcgaccc     1200

tgtcttgtcg cgcgagtcaa agtgttggtt cttcttatct ggcttggtat cagcaaaagc     1260

ctggtcaagc gccgcgtctg ttgatttatg gcgcgttttc gcgcgcgact ggcattccgg     1320

accgattttc tggttctggt tctggcactg atttcactct gaccatttca cgcctggaac     1380

cggaggattt tgcggtgtac tattgccaac aatatggctc atcgccgtgg acgtttggcc     1440

aaggtactaa agttgagatt aaacttaatc cattaattaa tgaaatcagc aaaatcattt     1500

cagctgcagg taattttgat gttaaagagg aaagagctgc agcttcttta ttgcagttgt     1560

ccggtaatgc cagtgatttt tcatatggac ggaactcaat aactttgaca gcatcagcat     1620

aatttattaa tttaaataat agcaatctta ctgggctgtg ccacataaga ttgctatttt     1680

tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc cctggagatt     1740

ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag atttgacaca     1800

gacgggactg gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt agaactaaag     1860

gtaaaacagg taaaaaaaac aattgaccga ttaaacttta tttctttgcc cgcattagtc     1920

tggagagagg atggacgtca ttttattctg actaaagtca gtaaagaagc aaacagatat     1980

cttatttttg atctggagca acgaaatccc cgtgttctcg aacagtctga gtttgaggcg     2040

ttatatcagg ggcatattat tcttattgct tcccgttctt ctgttaccgg gaaactggca     2100

aaatttgact ttacctggtt tatccctgcc attataaaat acagaaaaat atttattgaa     2160

acccttgttg tatctgtttt tttacaatta tttgcattaa taacccccct tttttttcag     2220

gtggttatgg acaaagtatt agtacacagg gggttttcaa cccttaatgt tattactgtc     2280

gcattatctg ttgtggtggt gtttgagatt atactcagcg gtttaagaac ttacattttt     2340

gcacatagta caagtcggat tgatgttgag ttgggtgcca aactcttccg gcatttactg     2400

gcgctaccga tctcttattt tgagagtcgt cgtgttggtg atactgttgc cagggtaaga     2460

gaattagacc agatccgtaa ttttctgaca ggacaggcat taacatctgt tctggactta     2520

ttattttcat tcatattttt tgcggtaatg tggtattaca gcccaaagct tactctggtg     2580

atcttatttt cgctgccctg ttatgctgca tggtctgttt ttattagccc cattttgcga     2640

cgtcgccttg atgataagtt ttcacggaat gcggataatc aatctttcct ggtggaatca     2700

gtcacggcga ttaacactat aaaagctatg gcagtctcac ctcagatgac gaacatatgg     2760

gacaaacaat tggcaggata tgttgctgca ggctttaaag tgacagtatt agccaccatt     2820

ggtcaacaag gaatacagtt aatacaaaag actgttatga tcatcaacct gtggttggga     2880

gcacacctgg ttatttccgg ggatttaagt attggtcagt taattgcttt taatatgctt     2940

gctggtcaga ttgttgcacc ggttattcgc cttgcacaaa tctggcagga tttccagcag     3000

gttggtatat cagttacccg ccttggtgat gtgcttaact ctccaactga aagttatcat     3060

gggaaactgg cattaccgga aattaatggt aatatcactt ttcgtaatat ccggtttcgc     3120

tataagcctg actctccggt tattttagat aatatcaatc tcagtattaa gcagggggag     3180

gttattggta ttgtcggacg ttctggttca ggaaaaagca cattaactaa attaattcaa     3240

cgtttttata ttcctgaaaa tggccaggtc ttaattgatg gacatgatct tgcgttggcc     3300

gatcctaact ggttacgtcg tcaggtgggg gttgtgttgc aggacaatgt gctgcttaat     3360

cgcagtatta ttgataatat ctcactggct aatcctggta tgtccgtcga aaaagttatt     3420

tatgcagcga aattagcagg cgctcatgat tttatttctg aattgcgtga ggggtataac     3480

accattgtcg gggaacaggg ggcaggatta tccggaggtc aacgtcaacg catcgcaatt     3540

gcaagggcgc tggtgaacaa ccctaaaata cttatttttg atgaagcaac cagtgctctg     3600

gattatgagt cggagcatat catcatgcgc aatatgcaca aaatatgtaa gggcagaacg     3660

gttataatca ttgctcatcg tctgtctaca gtaaaaaatg cagaccgcat tattgtcatg     3720

gaaaaaggga aaattgttga acagggtaaa cataaggaac tgctttctga accggaaagt     3780

ttatacagtt acttatatca gttacagtca gactaacaga aagaacagaa gaatatgaaa     3840

acatggttaa tggggttcag cgagttcctg ttgcgctata aacttgtctg gagtgaaaca     3900

tggaaaatcc ggaagcaatt agatactccg gtacgtgaaa aggacgaaaa tgaattctta     3960

cccgctcatc tggaattaat tgaaacgccg gtatccagac ggccgcgtct ggttgcttat     4020

tttattatgg ggtttctggt tattgctgtc attttatctg ttttaggtca ggtggaaatt     4080

gttgccactg caaatgggaa attaacacta agtgggcgca gcaaagaaat taaacctatt     4140

gaaaactcaa tagttaaaga aattatcgta aaagaaggag agtcagtccg gaaaggggat     4200

gtgttattaa agcttacagc actgggagct gaagctgata cgttaaaaac acagtcatca     4260

ctgttacaga ccaggctgga acaaactcgg tatcaaattc tgagcaggtc aattgaatta     4320

aataaactac ctgaactgaa gcttcctgat gagccttatt ttcagaatgt atctgaagag     4380

gaagtactgc gtttaacttc tttgataaaa gaacagtttt ccacatggca aaatcagaag     4440

tatcaaaaag aactgaatct ggataagaaa agagcagagc gattaacaat acttgcccgt     4500

ataaaccgtt atgaaaattt atcgagagtt gaaaaaagcc gtctggatga tttcaggagt     4560

ttattgcata aacaggcaat tgcaaaacat gctgtacttg agcaggagaa taaatatgtc     4620

gaggcagcaa atgaattacg ggtttataaa tcgcaactgg agcaaattga gagtgagata     4680

ttgtctgcaa aagaagaata tcagcttgtc acgcagcttt ttaaaaatga aattttagac     4740

aagctaagac aaacaacaga caacattgag ttattaactc tggagttaga gaaaaatgaa     4800

gagcgtcaac aggcttcagt aatcagggcc cctgtttcgg gaaaagttca gcaactgaag     4860

gttcatactg aaggtggggt tgttacaaca gcggaaacac tgatggtcat cgttccggaa     4920

gatgacacgc tggaggttac tgctctggta caaaataaag atattggttt tattaacgtc     4980

gggcagaatg ccatcattaa agtggaggcc tttccttaca cccgatatgg ttatctggtg     5040

ggtaaggtga aaaatataaa tttagatgca atagaagacc agaaactggg actcgttttt     5100

aatgtcattg tttctgttga agagaatgat ttgtcaaccg ggaataagca cattccatta     5160

agctcgggta tggctgtcac tgcagaaata aagactggaa tgcgaagcgt aatcagctat     5220

cttcttagtc ctctggaaga gtctgtaaca gaaagtttac atgagcgtta agtctcagag     5280

ccgcggtatc cggctcatat cttctcctg                                       5309


<210> 791
<211> 294
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv"

<400> 791
Met Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser 
                85                  90                  95      


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile Ser 
                165                 170                 175     


Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly 
    210                 215                 220                 


Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala 
                245                 250                 255     


Ala Gly Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu 
            260                 265                 270         


Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile 
        275                 280                 285             


Thr Leu Thr Ala Ser Ala 
    290                 


<210> 792
<211> 5309
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti CTLA-4 scFv"

<400> 792
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aatcacaacg      720

ctgagagaga gagaaatatg gaaattgtac tgacccagtc gcctggtacc ctgtctctgt      780

cgccgggtga acgtgctacc ctgtcttgtc gtgcttcgca atcggttggc tcgtcttatc      840

tggcatggta tcagcaaaaa ccgggccaag cgcctcgtct gctgatttat ggcgcgtttt      900

ctcgtgctac gggcattcct gatcgttttt cgggctctgg ctctggtact gattttacgc      960

tgactatcag ccgcttggaa cctgaagatt ttgcggttta ttattgccaa caatatggct     1020

cttctccgtg gacgtttggt caaggcacta aagttgaaat taaaggtggt ggctcgggcg     1080

gtggttctgg tggtggtagt ggtggtggtc aagtgcagtt ggttgaatcg ggtggcggtg     1140

ttgtgcagcc gggccgttcg ttgcgtctgt cttgcgcagc gagtggtttc accttctctt     1200

cttatactat gcactgggtg cgtcaagcac ctggcaaagg tctggagtgg gtaactttta     1260

tttcatacga tggtaataat aaatattatg cagattctgt taaaggtcgc tttacgattt     1320

ctcgcgataa ttcaaaaaat acgctgtatc tgcagatgaa ttcgctgcgc gctgaggata     1380

ctgcgatcta ctattgtgcg cgtactggtt ggctgggtcc gtttgattac tggggccaag     1440

gtacgctggt tacagtttcg tcgcttaatc cattaattaa tgaaatcagc aaaatcattt     1500

cagctgcagg taattttgat gttaaagagg aaagagctgc agcttcttta ttgcagttgt     1560

ccggtaatgc cagtgatttt tcatatggac ggaactcaat aactttgaca gcatcagcat     1620

aatttattaa tttaaataat agcaatctta ctgggctgtg ccacataaga ttgctatttt     1680

tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc cctggagatt     1740

ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag atttgacaca     1800

gacgggactg gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt agaactaaag     1860

gtaaaacagg taaaaaaaac aattgaccga ttaaacttta tttctttgcc cgcattagtc     1920

tggagagagg atggacgtca ttttattctg actaaagtca gtaaagaagc aaacagatat     1980

cttatttttg atctggagca acgaaatccc cgtgttctcg aacagtctga gtttgaggcg     2040

ttatatcagg ggcatattat tcttattgct tcccgttctt ctgttaccgg gaaactggca     2100

aaatttgact ttacctggtt tatccctgcc attataaaat acagaaaaat atttattgaa     2160

acccttgttg tatctgtttt tttacaatta tttgcattaa taacccccct tttttttcag     2220

gtggttatgg acaaagtatt agtacacagg gggttttcaa cccttaatgt tattactgtc     2280

gcattatctg ttgtggtggt gtttgagatt atactcagcg gtttaagaac ttacattttt     2340

gcacatagta caagtcggat tgatgttgag ttgggtgcca aactcttccg gcatttactg     2400

gcgctaccga tctcttattt tgagagtcgt cgtgttggtg atactgttgc cagggtaaga     2460

gaattagacc agatccgtaa ttttctgaca ggacaggcat taacatctgt tctggactta     2520

ttattttcat tcatattttt tgcggtaatg tggtattaca gcccaaagct tactctggtg     2580

atcttatttt cgctgccctg ttatgctgca tggtctgttt ttattagccc cattttgcga     2640

cgtcgccttg atgataagtt ttcacggaat gcggataatc aatctttcct ggtggaatca     2700

gtcacggcga ttaacactat aaaagctatg gcagtctcac ctcagatgac gaacatatgg     2760

gacaaacaat tggcaggata tgttgctgca ggctttaaag tgacagtatt agccaccatt     2820

ggtcaacaag gaatacagtt aatacaaaag actgttatga tcatcaacct gtggttggga     2880

gcacacctgg ttatttccgg ggatttaagt attggtcagt taattgcttt taatatgctt     2940

gctggtcaga ttgttgcacc ggttattcgc cttgcacaaa tctggcagga tttccagcag     3000

gttggtatat cagttacccg ccttggtgat gtgcttaact ctccaactga aagttatcat     3060

gggaaactgg cattaccgga aattaatggt aatatcactt ttcgtaatat ccggtttcgc     3120

tataagcctg actctccggt tattttagat aatatcaatc tcagtattaa gcagggggag     3180

gttattggta ttgtcggacg ttctggttca ggaaaaagca cattaactaa attaattcaa     3240

cgtttttata ttcctgaaaa tggccaggtc ttaattgatg gacatgatct tgcgttggcc     3300

gatcctaact ggttacgtcg tcaggtgggg gttgtgttgc aggacaatgt gctgcttaat     3360

cgcagtatta ttgataatat ctcactggct aatcctggta tgtccgtcga aaaagttatt     3420

tatgcagcga aattagcagg cgctcatgat tttatttctg aattgcgtga ggggtataac     3480

accattgtcg gggaacaggg ggcaggatta tccggaggtc aacgtcaacg catcgcaatt     3540

gcaagggcgc tggtgaacaa ccctaaaata cttatttttg atgaagcaac cagtgctctg     3600

gattatgagt cggagcatat catcatgcgc aatatgcaca aaatatgtaa gggcagaacg     3660

gttataatca ttgctcatcg tctgtctaca gtaaaaaatg cagaccgcat tattgtcatg     3720

gaaaaaggga aaattgttga acagggtaaa cataaggaac tgctttctga accggaaagt     3780

ttatacagtt acttatatca gttacagtca gactaacaga aagaacagaa gaatatgaaa     3840

acatggttaa tggggttcag cgagttcctg ttgcgctata aacttgtctg gagtgaaaca     3900

tggaaaatcc ggaagcaatt agatactccg gtacgtgaaa aggacgaaaa tgaattctta     3960

cccgctcatc tggaattaat tgaaacgccg gtatccagac ggccgcgtct ggttgcttat     4020

tttattatgg ggtttctggt tattgctgtc attttatctg ttttaggtca ggtggaaatt     4080

gttgccactg caaatgggaa attaacacta agtgggcgca gcaaagaaat taaacctatt     4140

gaaaactcaa tagttaaaga aattatcgta aaagaaggag agtcagtccg gaaaggggat     4200

gtgttattaa agcttacagc actgggagct gaagctgata cgttaaaaac acagtcatca     4260

ctgttacaga ccaggctgga acaaactcgg tatcaaattc tgagcaggtc aattgaatta     4320

aataaactac ctgaactgaa gcttcctgat gagccttatt ttcagaatgt atctgaagag     4380

gaagtactgc gtttaacttc tttgataaaa gaacagtttt ccacatggca aaatcagaag     4440

tatcaaaaag aactgaatct ggataagaaa agagcagagc gattaacaat acttgcccgt     4500

ataaaccgtt atgaaaattt atcgagagtt gaaaaaagcc gtctggatga tttcaggagt     4560

ttattgcata aacaggcaat tgcaaaacat gctgtacttg agcaggagaa taaatatgtc     4620

gaggcagcaa atgaattacg ggtttataaa tcgcaactgg agcaaattga gagtgagata     4680

ttgtctgcaa aagaagaata tcagcttgtc acgcagcttt ttaaaaatga aattttagac     4740

aagctaagac aaacaacaga caacattgag ttattaactc tggagttaga gaaaaatgaa     4800

gagcgtcaac aggcttcagt aatcagggcc cctgtttcgg gaaaagttca gcaactgaag     4860

gttcatactg aaggtggggt tgttacaaca gcggaaacac tgatggtcat cgttccggaa     4920

gatgacacgc tggaggttac tgctctggta caaaataaag atattggttt tattaacgtc     4980

gggcagaatg ccatcattaa agtggaggcc tttccttaca cccgatatgg ttatctggtg     5040

ggtaaggtga aaaatataaa tttagatgca atagaagacc agaaactggg actcgttttt     5100

aatgtcattg tttctgttga agagaatgat ttgtcaaccg ggaataagca cattccatta     5160

agctcgggta tggctgtcac tgcagaaata aagactggaa tgcgaagcgt aatcagctat     5220

cttcttagtc ctctggaaga gtctgtaaca gaaagtttac atgagcgtta agtctcagag     5280

ccgcggtatc cggctcatat cttctcctg                                       5309


<210> 793
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PD-1 scFv"

<400> 793
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn 
            20                  25                  30          


Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
    130                 135                 140                 


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
                165                 170                 175     


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
        195                 200                 205             


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro 
    210                 215                 220                 


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Leu Asn Pro Leu 
225                 230                 235                 240 


Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Asn Phe Asp Val 
                245                 250                 255     


Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala 
            260                 265                 270         


Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Ala Ser Ala 
        275                 280                 285             


<210> 794
<211> 5291
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PD-1 scFv"

<400> 794
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aagttaaatt      720

gaggaggagg cagttccatg caagtacaac tggttgaatc cggcggagga gtggtgcaac      780

cgggccgcag tttgcgtctg gattgtaaag cttcaggcat cactttttct aattctggta      840

tgcactgggt tcgccaagct ccgggtaaag gtctggagtg ggttgcggtg atctggtatg      900

atggttctaa acgatattat gcggatagtg ttaagggtcg ttttactatt tctcgtgata      960

attctaagaa caccttgttt ctgcagatga atagtctgcg cgctgaggat actgcggtat     1020

attattgtgc gactaatgac gattattggg gccaaggcac gctggttacc gtgagctctg     1080

gtggtggttc gggtggtggt tctggtggtg ggagcggcgg tggcgagatc gttctgactc     1140

aaagcccggc gactctgagt ctgagtccgg gtgaacgtgc gactctgagc tgccgtgcgt     1200

ctcagagtgt gtcgagttat ctggcgtggt accaacaaaa accgggccag gcgccgcgac     1260

tgctgattta tgatgcttct aatcgtgcga ctggtattcc ggcgcgcttt agcggttctg     1320

gctcaggcac tgacttcact ctgactattt cttcgctgga accggaagat tttgcggtgt     1380

actattgtca acaatcatct aattggcctc gtacgttcgg tcaaggtaca aaagtggaga     1440

taaaacttaa tccattaatt aatgaaatca gcaaaatcat ttcagctgca ggtaattttg     1500

atgttaaaga ggaaagagct gcagcttctt tattgcagtt gtccggtaat gccagtgatt     1560

tttcatatgg acggaactca ataactttga cagcatcagc ataatttatt aatttaaata     1620

atagcaatct tactgggctg tgccacataa gattgctatt tttttggagt cataatggat     1680

tcttgtcata aaattgatta tgggttatac gccctggaga ttttagccca ataccataac     1740

gtctctgtta acccggaaga aattaaacat agatttgaca cagacgggac tggtctggga     1800

ttaacgtcat ggttgcttgc tgcgaaatct ttagaactaa aggtaaaaca ggtaaaaaaa     1860

acaattgacc gattaaactt tatttctttg cccgcattag tctggagaga ggatggacgt     1920

cattttattc tgactaaagt cagtaaagaa gcaaacagat atcttatttt tgatctggag     1980

caacgaaatc cccgtgttct cgaacagtct gagtttgagg cgttatatca ggggcatatt     2040

attcttattg cttcccgttc ttctgttacc gggaaactgg caaaatttga ctttacctgg     2100

tttatccctg ccattataaa atacagaaaa atatttattg aaacccttgt tgtatctgtt     2160

tttttacaat tatttgcatt aataaccccc cttttttttc aggtggttat ggacaaagta     2220

ttagtacaca gggggttttc aacccttaat gttattactg tcgcattatc tgttgtggtg     2280

gtgtttgaga ttatactcag cggtttaaga acttacattt ttgcacatag tacaagtcgg     2340

attgatgttg agttgggtgc caaactcttc cggcatttac tggcgctacc gatctcttat     2400

tttgagagtc gtcgtgttgg tgatactgtt gccagggtaa gagaattaga ccagatccgt     2460

aattttctga caggacaggc attaacatct gttctggact tattattttc attcatattt     2520

tttgcggtaa tgtggtatta cagcccaaag cttactctgg tgatcttatt ttcgctgccc     2580

tgttatgctg catggtctgt ttttattagc cccattttgc gacgtcgcct tgatgataag     2640

ttttcacgga atgcggataa tcaatctttc ctggtggaat cagtcacggc gattaacact     2700

ataaaagcta tggcagtctc acctcagatg acgaacatat gggacaaaca attggcagga     2760

tatgttgctg caggctttaa agtgacagta ttagccacca ttggtcaaca aggaatacag     2820

ttaatacaaa agactgttat gatcatcaac ctgtggttgg gagcacacct ggttatttcc     2880

ggggatttaa gtattggtca gttaattgct tttaatatgc ttgctggtca gattgttgca     2940

ccggttattc gccttgcaca aatctggcag gatttccagc aggttggtat atcagttacc     3000

cgccttggtg atgtgcttaa ctctccaact gaaagttatc atgggaaact ggcattaccg     3060

gaaattaatg gtaatatcac ttttcgtaat atccggtttc gctataagcc tgactctccg     3120

gttattttag ataatatcaa tctcagtatt aagcaggggg aggttattgg tattgtcgga     3180

cgttctggtt caggaaaaag cacattaact aaattaattc aacgttttta tattcctgaa     3240

aatggccagg tcttaattga tggacatgat cttgcgttgg ccgatcctaa ctggttacgt     3300

cgtcaggtgg gggttgtgtt gcaggacaat gtgctgctta atcgcagtat tattgataat     3360

atctcactgg ctaatcctgg tatgtccgtc gaaaaagtta tttatgcagc gaaattagca     3420

ggcgctcatg attttatttc tgaattgcgt gaggggtata acaccattgt cggggaacag     3480

ggggcaggat tatccggagg tcaacgtcaa cgcatcgcaa ttgcaagggc gctggtgaac     3540

aaccctaaaa tacttatttt tgatgaagca accagtgctc tggattatga gtcggagcat     3600

atcatcatgc gcaatatgca caaaatatgt aagggcagaa cggttataat cattgctcat     3660

cgtctgtcta cagtaaaaaa tgcagaccgc attattgtca tggaaaaagg gaaaattgtt     3720

gaacagggta aacataagga actgctttct gaaccggaaa gtttatacag ttacttatat     3780

cagttacagt cagactaaca gaaagaacag aagaatatga aaacatggtt aatggggttc     3840

agcgagttcc tgttgcgcta taaacttgtc tggagtgaaa catggaaaat ccggaagcaa     3900

ttagatactc cggtacgtga aaaggacgaa aatgaattct tacccgctca tctggaatta     3960

attgaaacgc cggtatccag acggccgcgt ctggttgctt attttattat ggggtttctg     4020

gttattgctg tcattttatc tgttttaggt caggtggaaa ttgttgccac tgcaaatggg     4080

aaattaacac taagtgggcg cagcaaagaa attaaaccta ttgaaaactc aatagttaaa     4140

gaaattatcg taaaagaagg agagtcagtc cggaaagggg atgtgttatt aaagcttaca     4200

gcactgggag ctgaagctga tacgttaaaa acacagtcat cactgttaca gaccaggctg     4260

gaacaaactc ggtatcaaat tctgagcagg tcaattgaat taaataaact acctgaactg     4320

aagcttcctg atgagcctta ttttcagaat gtatctgaag aggaagtact gcgtttaact     4380

tctttgataa aagaacagtt ttccacatgg caaaatcaga agtatcaaaa agaactgaat     4440

ctggataaga aaagagcaga gcgattaaca atacttgccc gtataaaccg ttatgaaaat     4500

ttatcgagag ttgaaaaaag ccgtctggat gatttcagga gtttattgca taaacaggca     4560

attgcaaaac atgctgtact tgagcaggag aataaatatg tcgaggcagc aaatgaatta     4620

cgggtttata aatcgcaact ggagcaaatt gagagtgaga tattgtctgc aaaagaagaa     4680

tatcagcttg tcacgcagct ttttaaaaat gaaattttag acaagctaag acaaacaaca     4740

gacaacattg agttattaac tctggagtta gagaaaaatg aagagcgtca acaggcttca     4800

gtaatcaggg cccctgtttc gggaaaagtt cagcaactga aggttcatac tgaaggtggg     4860

gttgttacaa cagcggaaac actgatggtc atcgttccgg aagatgacac gctggaggtt     4920

actgctctgg tacaaaataa agatattggt tttattaacg tcgggcagaa tgccatcatt     4980

aaagtggagg cctttcctta cacccgatat ggttatctgg tgggtaaggt gaaaaatata     5040

aatttagatg caatagaaga ccagaaactg ggactcgttt ttaatgtcat tgtttctgtt     5100

gaagagaatg atttgtcaac cgggaataag cacattccat taagctcggg tatggctgtc     5160

actgcagaaa taaagactgg aatgcgaagc gtaatcagct atcttcttag tcctctggaa     5220

gagtctgtaa cagaaagttt acatgagcgt taagtctcag agccgcggta tccggctcat     5280

atcttctcct g                                                          5291


<210> 795
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PD-1 scFv"

<400> 795
Met Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gln Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp 
    130                 135                 140                 


Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr 
                165                 170                 175     


Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Leu Asn Pro Leu 
225                 230                 235                 240 


Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Asn Phe Asp Val 
                245                 250                 255     


Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala 
            260                 265                 270         


Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Ala Ser Ala 
        275                 280                 285             


<210> 796
<211> 5291
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PD-1 scFv"

<400> 796
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aatataccga      720

acgcttaagg aggctttatg gaaatcgtgc tgactcagag tccggcgact ctgtctctga      780

gtccgggcga acgcgcgact ctgtcttgcc gtgcgtctca atctgtgtct tcatacttgg      840

cttggtacca acaaaaaccg ggccaggcgc cgcgactgtt gatttatgat gcgtcgaatc      900

gcgcgactgg cattccggcg cgcttttcgg gtagcggttc tggtactgat tttacgctga      960

ctatctcttc tctggagcct gaagatttcg ctgtttatta ctgccaacag tctagtaatt     1020

ggccgcgtac tttcggccag ggcactaagg tggaaattaa aggtggcggc tcgggcggcg     1080

gctcgggtgg tggttctggt ggtggccaag tgcaactggt ggaaagtggc ggcggggtgg     1140

tgcaaccggg ccgttctctg cgcctggatt gtaaagcttc aggcattact tttagcaact     1200

ctggtatgca ctgggttcgc caagctccgg gcaaaggcct ggaatgggtg gcggttattt     1260

ggtacgatgg ctctaaacgt tattacgctg acagtgttaa aggccgcttt accatttctc     1320

gtgataattc taaaaatacc ctgtttctgc aaatgaactc gctgcgcgcg gaagatactg     1380

ctgtttacta ttgtgcgact aatgatgatt actggggtca aggtaccctg gttaccgtgt     1440

cttctcttaa tccattaatt aatgaaatca gcaaaatcat ttcagctgca ggtaattttg     1500

atgttaaaga ggaaagagct gcagcttctt tattgcagtt gtccggtaat gccagtgatt     1560

tttcatatgg acggaactca ataactttga cagcatcagc ataatttatt aatttaaata     1620

atagcaatct tactgggctg tgccacataa gattgctatt tttttggagt cataatggat     1680

tcttgtcata aaattgatta tgggttatac gccctggaga ttttagccca ataccataac     1740

gtctctgtta acccggaaga aattaaacat agatttgaca cagacgggac tggtctggga     1800

ttaacgtcat ggttgcttgc tgcgaaatct ttagaactaa aggtaaaaca ggtaaaaaaa     1860

acaattgacc gattaaactt tatttctttg cccgcattag tctggagaga ggatggacgt     1920

cattttattc tgactaaagt cagtaaagaa gcaaacagat atcttatttt tgatctggag     1980

caacgaaatc cccgtgttct cgaacagtct gagtttgagg cgttatatca ggggcatatt     2040

attcttattg cttcccgttc ttctgttacc gggaaactgg caaaatttga ctttacctgg     2100

tttatccctg ccattataaa atacagaaaa atatttattg aaacccttgt tgtatctgtt     2160

tttttacaat tatttgcatt aataaccccc cttttttttc aggtggttat ggacaaagta     2220

ttagtacaca gggggttttc aacccttaat gttattactg tcgcattatc tgttgtggtg     2280

gtgtttgaga ttatactcag cggtttaaga acttacattt ttgcacatag tacaagtcgg     2340

attgatgttg agttgggtgc caaactcttc cggcatttac tggcgctacc gatctcttat     2400

tttgagagtc gtcgtgttgg tgatactgtt gccagggtaa gagaattaga ccagatccgt     2460

aattttctga caggacaggc attaacatct gttctggact tattattttc attcatattt     2520

tttgcggtaa tgtggtatta cagcccaaag cttactctgg tgatcttatt ttcgctgccc     2580

tgttatgctg catggtctgt ttttattagc cccattttgc gacgtcgcct tgatgataag     2640

ttttcacgga atgcggataa tcaatctttc ctggtggaat cagtcacggc gattaacact     2700

ataaaagcta tggcagtctc acctcagatg acgaacatat gggacaaaca attggcagga     2760

tatgttgctg caggctttaa agtgacagta ttagccacca ttggtcaaca aggaatacag     2820

ttaatacaaa agactgttat gatcatcaac ctgtggttgg gagcacacct ggttatttcc     2880

ggggatttaa gtattggtca gttaattgct tttaatatgc ttgctggtca gattgttgca     2940

ccggttattc gccttgcaca aatctggcag gatttccagc aggttggtat atcagttacc     3000

cgccttggtg atgtgcttaa ctctccaact gaaagttatc atgggaaact ggcattaccg     3060

gaaattaatg gtaatatcac ttttcgtaat atccggtttc gctataagcc tgactctccg     3120

gttattttag ataatatcaa tctcagtatt aagcaggggg aggttattgg tattgtcgga     3180

cgttctggtt caggaaaaag cacattaact aaattaattc aacgttttta tattcctgaa     3240

aatggccagg tcttaattga tggacatgat cttgcgttgg ccgatcctaa ctggttacgt     3300

cgtcaggtgg gggttgtgtt gcaggacaat gtgctgctta atcgcagtat tattgataat     3360

atctcactgg ctaatcctgg tatgtccgtc gaaaaagtta tttatgcagc gaaattagca     3420

ggcgctcatg attttatttc tgaattgcgt gaggggtata acaccattgt cggggaacag     3480

ggggcaggat tatccggagg tcaacgtcaa cgcatcgcaa ttgcaagggc gctggtgaac     3540

aaccctaaaa tacttatttt tgatgaagca accagtgctc tggattatga gtcggagcat     3600

atcatcatgc gcaatatgca caaaatatgt aagggcagaa cggttataat cattgctcat     3660

cgtctgtcta cagtaaaaaa tgcagaccgc attattgtca tggaaaaagg gaaaattgtt     3720

gaacagggta aacataagga actgctttct gaaccggaaa gtttatacag ttacttatat     3780

cagttacagt cagactaaca gaaagaacag aagaatatga aaacatggtt aatggggttc     3840

agcgagttcc tgttgcgcta taaacttgtc tggagtgaaa catggaaaat ccggaagcaa     3900

ttagatactc cggtacgtga aaaggacgaa aatgaattct tacccgctca tctggaatta     3960

attgaaacgc cggtatccag acggccgcgt ctggttgctt attttattat ggggtttctg     4020

gttattgctg tcattttatc tgttttaggt caggtggaaa ttgttgccac tgcaaatggg     4080

aaattaacac taagtgggcg cagcaaagaa attaaaccta ttgaaaactc aatagttaaa     4140

gaaattatcg taaaagaagg agagtcagtc cggaaagggg atgtgttatt aaagcttaca     4200

gcactgggag ctgaagctga tacgttaaaa acacagtcat cactgttaca gaccaggctg     4260

gaacaaactc ggtatcaaat tctgagcagg tcaattgaat taaataaact acctgaactg     4320

aagcttcctg atgagcctta ttttcagaat gtatctgaag aggaagtact gcgtttaact     4380

tctttgataa aagaacagtt ttccacatgg caaaatcaga agtatcaaaa agaactgaat     4440

ctggataaga aaagagcaga gcgattaaca atacttgccc gtataaaccg ttatgaaaat     4500

ttatcgagag ttgaaaaaag ccgtctggat gatttcagga gtttattgca taaacaggca     4560

attgcaaaac atgctgtact tgagcaggag aataaatatg tcgaggcagc aaatgaatta     4620

cgggtttata aatcgcaact ggagcaaatt gagagtgaga tattgtctgc aaaagaagaa     4680

tatcagcttg tcacgcagct ttttaaaaat gaaattttag acaagctaag acaaacaaca     4740

gacaacattg agttattaac tctggagtta gagaaaaatg aagagcgtca acaggcttca     4800

gtaatcaggg cccctgtttc gggaaaagtt cagcaactga aggttcatac tgaaggtggg     4860

gttgttacaa cagcggaaac actgatggtc atcgttccgg aagatgacac gctggaggtt     4920

actgctctgg tacaaaataa agatattggt tttattaacg tcgggcagaa tgccatcatt     4980

aaagtggagg cctttcctta cacccgatat ggttatctgg tgggtaaggt gaaaaatata     5040

aatttagatg caatagaaga ccagaaactg ggactcgttt ttaatgtcat tgtttctgtt     5100

gaagagaatg atttgtcaac cgggaataag cacattccat taagctcggg tatggctgtc     5160

actgcagaaa taaagactgg aatgcgaagc gtaatcagct atcttcttag tcctctggaa     5220

gagtctgtaa cagaaagttt acatgagcgt taagtctcag agccgcggta tccggctcat     5280

atcttctcct g                                                          5291


<210> 797
<211> 294
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PDL-1 scFv"

<400> 797
Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp 
            20                  25                  30          


Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala 
                245                 250                 255     


Ala Gly Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu 
            260                 265                 270         


Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile 
        275                 280                 285             


Thr Leu Thr Ala Ser Ala 
    290                 


<210> 798
<211> 5309
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PDL-1 scFv"

<400> 798
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aagataggga      720

ccaggtaagg aggatgaatg gaagtgcagc tggtggagtc aggtggaggc ttggtgcaac      780

cgggcggttc actgcgtctg tcatgtgcgg cgtctgggtt tacttttagt gactcttgga      840

ttcactgggt gcgccaggct ccgggtaaag gcctggaatg ggtagcttgg attagtcctt      900

acggtggctc gacctattat gctgattcgg taaagggtcg ctttactatt agcgctgata      960

cttctaaaaa tactgcatac ctgcagatga atagcctgcg cgctgaggat actgctgtgt     1020

attattgcgc gcgtcgccac tggccgggcg gctttgatta ttggggccaa ggtactctgg     1080

ttaccgtgtc tagtggcggt ggtagcggcg gcggctcagg tggcggctcg ggcggtggcg     1140

acattcagat gactcagtct ccgtcttctt tgtcggcgag cgtgggcgat cgtgttacca     1200

tcacgtgtcg cgcgagccaa gatgtgtcga ctgcggtggc ttggtatcaa caaaaaccgg     1260

gtaaagctcc gaaactgctg atttatagtg cgtctttttt gtattctggt gttccgtctc     1320

gtttctctgg ctcaggtagc ggtactgatt ttacgctgac tatttcttca ctgcaaccgg     1380

aagattttgc tacgtattat tgtcaacaat atctgtatca cccggcgacg tttggtcagg     1440

gtactaaggt ggagataaaa cgccttaatc cattaattaa tgaaatcagc aaaatcattt     1500

cagctgcagg taattttgat gttaaagagg aaagagctgc agcttcttta ttgcagttgt     1560

ccggtaatgc cagtgatttt tcatatggac ggaactcaat aactttgaca gcatcagcat     1620

aatttattaa tttaaataat agcaatctta ctgggctgtg ccacataaga ttgctatttt     1680

tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc cctggagatt     1740

ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag atttgacaca     1800

gacgggactg gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt agaactaaag     1860

gtaaaacagg taaaaaaaac aattgaccga ttaaacttta tttctttgcc cgcattagtc     1920

tggagagagg atggacgtca ttttattctg actaaagtca gtaaagaagc aaacagatat     1980

cttatttttg atctggagca acgaaatccc cgtgttctcg aacagtctga gtttgaggcg     2040

ttatatcagg ggcatattat tcttattgct tcccgttctt ctgttaccgg gaaactggca     2100

aaatttgact ttacctggtt tatccctgcc attataaaat acagaaaaat atttattgaa     2160

acccttgttg tatctgtttt tttacaatta tttgcattaa taacccccct tttttttcag     2220

gtggttatgg acaaagtatt agtacacagg gggttttcaa cccttaatgt tattactgtc     2280

gcattatctg ttgtggtggt gtttgagatt atactcagcg gtttaagaac ttacattttt     2340

gcacatagta caagtcggat tgatgttgag ttgggtgcca aactcttccg gcatttactg     2400

gcgctaccga tctcttattt tgagagtcgt cgtgttggtg atactgttgc cagggtaaga     2460

gaattagacc agatccgtaa ttttctgaca ggacaggcat taacatctgt tctggactta     2520

ttattttcat tcatattttt tgcggtaatg tggtattaca gcccaaagct tactctggtg     2580

atcttatttt cgctgccctg ttatgctgca tggtctgttt ttattagccc cattttgcga     2640

cgtcgccttg atgataagtt ttcacggaat gcggataatc aatctttcct ggtggaatca     2700

gtcacggcga ttaacactat aaaagctatg gcagtctcac ctcagatgac gaacatatgg     2760

gacaaacaat tggcaggata tgttgctgca ggctttaaag tgacagtatt agccaccatt     2820

ggtcaacaag gaatacagtt aatacaaaag actgttatga tcatcaacct gtggttggga     2880

gcacacctgg ttatttccgg ggatttaagt attggtcagt taattgcttt taatatgctt     2940

gctggtcaga ttgttgcacc ggttattcgc cttgcacaaa tctggcagga tttccagcag     3000

gttggtatat cagttacccg ccttggtgat gtgcttaact ctccaactga aagttatcat     3060

gggaaactgg cattaccgga aattaatggt aatatcactt ttcgtaatat ccggtttcgc     3120

tataagcctg actctccggt tattttagat aatatcaatc tcagtattaa gcagggggag     3180

gttattggta ttgtcggacg ttctggttca ggaaaaagca cattaactaa attaattcaa     3240

cgtttttata ttcctgaaaa tggccaggtc ttaattgatg gacatgatct tgcgttggcc     3300

gatcctaact ggttacgtcg tcaggtgggg gttgtgttgc aggacaatgt gctgcttaat     3360

cgcagtatta ttgataatat ctcactggct aatcctggta tgtccgtcga aaaagttatt     3420

tatgcagcga aattagcagg cgctcatgat tttatttctg aattgcgtga ggggtataac     3480

accattgtcg gggaacaggg ggcaggatta tccggaggtc aacgtcaacg catcgcaatt     3540

gcaagggcgc tggtgaacaa ccctaaaata cttatttttg atgaagcaac cagtgctctg     3600

gattatgagt cggagcatat catcatgcgc aatatgcaca aaatatgtaa gggcagaacg     3660

gttataatca ttgctcatcg tctgtctaca gtaaaaaatg cagaccgcat tattgtcatg     3720

gaaaaaggga aaattgttga acagggtaaa cataaggaac tgctttctga accggaaagt     3780

ttatacagtt acttatatca gttacagtca gactaacaga aagaacagaa gaatatgaaa     3840

acatggttaa tggggttcag cgagttcctg ttgcgctata aacttgtctg gagtgaaaca     3900

tggaaaatcc ggaagcaatt agatactccg gtacgtgaaa aggacgaaaa tgaattctta     3960

cccgctcatc tggaattaat tgaaacgccg gtatccagac ggccgcgtct ggttgcttat     4020

tttattatgg ggtttctggt tattgctgtc attttatctg ttttaggtca ggtggaaatt     4080

gttgccactg caaatgggaa attaacacta agtgggcgca gcaaagaaat taaacctatt     4140

gaaaactcaa tagttaaaga aattatcgta aaagaaggag agtcagtccg gaaaggggat     4200

gtgttattaa agcttacagc actgggagct gaagctgata cgttaaaaac acagtcatca     4260

ctgttacaga ccaggctgga acaaactcgg tatcaaattc tgagcaggtc aattgaatta     4320

aataaactac ctgaactgaa gcttcctgat gagccttatt ttcagaatgt atctgaagag     4380

gaagtactgc gtttaacttc tttgataaaa gaacagtttt ccacatggca aaatcagaag     4440

tatcaaaaag aactgaatct ggataagaaa agagcagagc gattaacaat acttgcccgt     4500

ataaaccgtt atgaaaattt atcgagagtt gaaaaaagcc gtctggatga tttcaggagt     4560

ttattgcata aacaggcaat tgcaaaacat gctgtacttg agcaggagaa taaatatgtc     4620

gaggcagcaa atgaattacg ggtttataaa tcgcaactgg agcaaattga gagtgagata     4680

ttgtctgcaa aagaagaata tcagcttgtc acgcagcttt ttaaaaatga aattttagac     4740

aagctaagac aaacaacaga caacattgag ttattaactc tggagttaga gaaaaatgaa     4800

gagcgtcaac aggcttcagt aatcagggcc cctgtttcgg gaaaagttca gcaactgaag     4860

gttcatactg aaggtggggt tgttacaaca gcggaaacac tgatggtcat cgttccggaa     4920

gatgacacgc tggaggttac tgctctggta caaaataaag atattggttt tattaacgtc     4980

gggcagaatg ccatcattaa agtggaggcc tttccttaca cccgatatgg ttatctggtg     5040

ggtaaggtga aaaatataaa tttagatgca atagaagacc agaaactggg actcgttttt     5100

aatgtcattg tttctgttga agagaatgat ttgtcaaccg ggaataagca cattccatta     5160

agctcgggta tggctgtcac tgcagaaata aagactggaa tgcgaagcgt aatcagctat     5220

cttcttagtc ctctggaaga gtctgtaaca gaaagtttac atgagcgtta agtctcagag     5280

ccgcggtatc cggctcatat cttctcctg                                       5309


<210> 799
<211> 294
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="anti PDL-1 scFv"

<400> 799
Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr 
            20                  25                  30          


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro 
                85                  90                  95      


Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
                165                 170                 175     


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
    210                 215                 220                 


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala 
                245                 250                 255     


Ala Gly Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu 
            260                 265                 270         


Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile 
        275                 280                 285             


Thr Leu Thr Ala Ser Ala 
    290                 


<210> 800
<211> 5309
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="anti PDL-1 scFv"

<400> 800
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aaataaatcc      720

cttcatgagg aggtaagatg gatattcaaa tgactcaatc tccgagctct ctgagtgcgt      780

ctgtgggtga tcgtgtgact attacttgtc gtgcgtctca agatgtttca actgcggttg      840

cgtggtatca acagaaaccg ggcaaggcgc ctaagctgct gatttattct gcttcgttcc      900

tgtacagcgg tgtgccgtct cgtttctctg gctctggttc gggtactgat ttcactctga      960

ctatttcgag tctgcagccg gaagattttg cgacttatta ttgtcaacaa tatctgtatc     1020

accctgcgac gtttggtcaa ggcacgaaag ttgaaattaa acgtggtggt ggctctggtg     1080

gtggcagcgg tggtgggtcg ggtggcggtg aagttcaact ggttgagtca ggtggtggcc     1140

tggtgcaacc gggcggctct ctgcgcctgt cttgtgctgc gtcgggtttt acgttctctg     1200

atagctggat tcactgggta cgccaggcac cgggcaaagg tctggaatgg gtagcttgga     1260

tttcacctta tggtggctct acttattacg cggatagcgt gaaaggtcgc tttactattt     1320

ctgcggacac tagcaaaaat actgcttacc tgcaaatgaa ttcgctgcgt gctgaggata     1380

ctgcagtgta ttactgtgcg cgtcgtcatt ggcctggcgg ctttgattat tggggtcaag     1440

gtactctggt tactgttagc agccttaatc cattaattaa tgaaatcagc aaaatcattt     1500

cagctgcagg taattttgat gttaaagagg aaagagctgc agcttcttta ttgcagttgt     1560

ccggtaatgc cagtgatttt tcatatggac ggaactcaat aactttgaca gcatcagcat     1620

aatttattaa tttaaataat agcaatctta ctgggctgtg ccacataaga ttgctatttt     1680

tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc cctggagatt     1740

ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag atttgacaca     1800

gacgggactg gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt agaactaaag     1860

gtaaaacagg taaaaaaaac aattgaccga ttaaacttta tttctttgcc cgcattagtc     1920

tggagagagg atggacgtca ttttattctg actaaagtca gtaaagaagc aaacagatat     1980

cttatttttg atctggagca acgaaatccc cgtgttctcg aacagtctga gtttgaggcg     2040

ttatatcagg ggcatattat tcttattgct tcccgttctt ctgttaccgg gaaactggca     2100

aaatttgact ttacctggtt tatccctgcc attataaaat acagaaaaat atttattgaa     2160

acccttgttg tatctgtttt tttacaatta tttgcattaa taacccccct tttttttcag     2220

gtggttatgg acaaagtatt agtacacagg gggttttcaa cccttaatgt tattactgtc     2280

gcattatctg ttgtggtggt gtttgagatt atactcagcg gtttaagaac ttacattttt     2340

gcacatagta caagtcggat tgatgttgag ttgggtgcca aactcttccg gcatttactg     2400

gcgctaccga tctcttattt tgagagtcgt cgtgttggtg atactgttgc cagggtaaga     2460

gaattagacc agatccgtaa ttttctgaca ggacaggcat taacatctgt tctggactta     2520

ttattttcat tcatattttt tgcggtaatg tggtattaca gcccaaagct tactctggtg     2580

atcttatttt cgctgccctg ttatgctgca tggtctgttt ttattagccc cattttgcga     2640

cgtcgccttg atgataagtt ttcacggaat gcggataatc aatctttcct ggtggaatca     2700

gtcacggcga ttaacactat aaaagctatg gcagtctcac ctcagatgac gaacatatgg     2760

gacaaacaat tggcaggata tgttgctgca ggctttaaag tgacagtatt agccaccatt     2820

ggtcaacaag gaatacagtt aatacaaaag actgttatga tcatcaacct gtggttggga     2880

gcacacctgg ttatttccgg ggatttaagt attggtcagt taattgcttt taatatgctt     2940

gctggtcaga ttgttgcacc ggttattcgc cttgcacaaa tctggcagga tttccagcag     3000

gttggtatat cagttacccg ccttggtgat gtgcttaact ctccaactga aagttatcat     3060

gggaaactgg cattaccgga aattaatggt aatatcactt ttcgtaatat ccggtttcgc     3120

tataagcctg actctccggt tattttagat aatatcaatc tcagtattaa gcagggggag     3180

gttattggta ttgtcggacg ttctggttca ggaaaaagca cattaactaa attaattcaa     3240

cgtttttata ttcctgaaaa tggccaggtc ttaattgatg gacatgatct tgcgttggcc     3300

gatcctaact ggttacgtcg tcaggtgggg gttgtgttgc aggacaatgt gctgcttaat     3360

cgcagtatta ttgataatat ctcactggct aatcctggta tgtccgtcga aaaagttatt     3420

tatgcagcga aattagcagg cgctcatgat tttatttctg aattgcgtga ggggtataac     3480

accattgtcg gggaacaggg ggcaggatta tccggaggtc aacgtcaacg catcgcaatt     3540

gcaagggcgc tggtgaacaa ccctaaaata cttatttttg atgaagcaac cagtgctctg     3600

gattatgagt cggagcatat catcatgcgc aatatgcaca aaatatgtaa gggcagaacg     3660

gttataatca ttgctcatcg tctgtctaca gtaaaaaatg cagaccgcat tattgtcatg     3720

gaaaaaggga aaattgttga acagggtaaa cataaggaac tgctttctga accggaaagt     3780

ttatacagtt acttatatca gttacagtca gactaacaga aagaacagaa gaatatgaaa     3840

acatggttaa tggggttcag cgagttcctg ttgcgctata aacttgtctg gagtgaaaca     3900

tggaaaatcc ggaagcaatt agatactccg gtacgtgaaa aggacgaaaa tgaattctta     3960

cccgctcatc tggaattaat tgaaacgccg gtatccagac ggccgcgtct ggttgcttat     4020

tttattatgg ggtttctggt tattgctgtc attttatctg ttttaggtca ggtggaaatt     4080

gttgccactg caaatgggaa attaacacta agtgggcgca gcaaagaaat taaacctatt     4140

gaaaactcaa tagttaaaga aattatcgta aaagaaggag agtcagtccg gaaaggggat     4200

gtgttattaa agcttacagc actgggagct gaagctgata cgttaaaaac acagtcatca     4260

ctgttacaga ccaggctgga acaaactcgg tatcaaattc tgagcaggtc aattgaatta     4320

aataaactac ctgaactgaa gcttcctgat gagccttatt ttcagaatgt atctgaagag     4380

gaagtactgc gtttaacttc tttgataaaa gaacagtttt ccacatggca aaatcagaag     4440

tatcaaaaag aactgaatct ggataagaaa agagcagagc gattaacaat acttgcccgt     4500

ataaaccgtt atgaaaattt atcgagagtt gaaaaaagcc gtctggatga tttcaggagt     4560

ttattgcata aacaggcaat tgcaaaacat gctgtacttg agcaggagaa taaatatgtc     4620

gaggcagcaa atgaattacg ggtttataaa tcgcaactgg agcaaattga gagtgagata     4680

ttgtctgcaa aagaagaata tcagcttgtc acgcagcttt ttaaaaatga aattttagac     4740

aagctaagac aaacaacaga caacattgag ttattaactc tggagttaga gaaaaatgaa     4800

gagcgtcaac aggcttcagt aatcagggcc cctgtttcgg gaaaagttca gcaactgaag     4860

gttcatactg aaggtggggt tgttacaaca gcggaaacac tgatggtcat cgttccggaa     4920

gatgacacgc tggaggttac tgctctggta caaaataaag atattggttt tattaacgtc     4980

gggcagaatg ccatcattaa agtggaggcc tttccttaca cccgatatgg ttatctggtg     5040

ggtaaggtga aaaatataaa tttagatgca atagaagacc agaaactggg actcgttttt     5100

aatgtcattg tttctgttga agagaatgat ttgtcaaccg ggaataagca cattccatta     5160

agctcgggta tggctgtcac tgcagaaata aagactggaa tgcgaagcgt aatcagctat     5220

cttcttagtc ctctggaaga gtctgtaaca gaaagtttac atgagcgtta agtctcagag     5280

ccgcggtatc cggctcatat cttctcctg                                       5309


<210> 801
<211> 104
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="fliC promoter"

<400> 801
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggt                       104


<210> 802
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="fliC 5 untranslated region"

<400> 802
tgacggcgat tgagccgacg ggtggaaacc caaaacgtaa tcaac                       45


<210> 803
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Tetracycline responsive promoter"

<400> 803
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaa                                 96


<210> 804
<211> 705
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Tetracycline responsive promoter"

<400> 804
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaa                      705


<210> 805
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 805
aaataaaaat gaggaggcaa ttcta                                             25


<210> 806
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 806
agattataag gagttaaata gaaaa                                             25


<210> 807
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 807
ctcaaagaat tataggaaag gaggaagcga taagt                                  35


<210> 808
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 808
atcaccaatt tgaggaaagg taaat                                             25


<210> 809
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 809
tggcagacgc ctaaggagga agacc                                             25


<210> 810
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 810
tacataattt tggggagggt actcg                                             25


<210> 811
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 811
ttaaatatca actagaggtc accaa                                             25


<210> 812
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 812
tacgatttaa ttcggaggtt ttttg                                             25


<210> 813
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 813
tcacaacgct gagagagaga gaaat                                             25


<210> 814
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 814
gttaaattga ggaggaggca gttcc                                             25


<210> 815
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 815
tataccgaac gcttaaggag gcttt                                             25


<210> 816
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 816
ataaatccct tcatgaggag gtaag                                             25


<210> 817
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized ribosome binding site"

<400> 817
gatagggacc aggtaaggag gatga                                             25


<210> 818
<211> 200
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Terminator sequence"

<400> 818
tcgccgtaac ctgattaact gagactgacg gcaacgccaa attgcctgat gcgctgcgct       60

tatcaggcct acaaggggaa ttgcaattta ttgaatttgc acatttttgt aggccggata      120

aggcgtttac gccgcatccg gcaacatgaa tggtaatttg ccagcaacgt gcttccccgc      180

caacggcggg gttttttctg                                                  200


<210> 819
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Terminator sequence"

<400> 819
ctctaacgga cttgagtgag gttgtaaagg gagttggctc ctcggtacca aattccagaa       60

aagaggcctc ccgaaagggg ggcctttttt cgtttt                                 96


<210> 820
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Terminator sequence"

<400> 820
gtctcagagc cgcggtatcc ggctcatatc ttctcctg                               38


<210> 821
<211> 177
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="N terminal secretion tag for Type V auto-secreter
      secretion"

<400> 821
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgc         177


<210> 822
<211> 921
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="C terminal secretion tag for Type V auto-secreter
      secretion"

<400> 822
ttcaaagcgg aggctgacaa ggccgctgca gcaaaagctg actcctttat gaacgcgggt       60

tacaaaaact tcatgaccga ggtaaataat ctcaataaac gtatgggtga tctgcgcgac      120

actaatgggg atgcaggcgc atgggcacgc attatgtctg gtgcaggttc ggcggatggc      180

gggtattctg acaattacac tcatgttcag gtgggcttcg ataaaaaaca tgagctggac      240

ggtgtggatc tgttcactgg cgtaaccatg acttatactg attcaagcgc agacagccac      300

gcattttcag gtaaaacgaa atcagttggc ggcggtctgt atgcgagcgc actgttcgag      360

agcggcgcct acattgatct aattggcaag tatattcacc atgataatga ttacacaggg      420

aactttgcag gcctgggcac caaacactat aacacgcatt catggtacgc tggcgcagaa      480

accggctata gataccacct gaccgaggaa acctttatcg aaccgcaagc ggaactggtt      540

tacggtgcgg tcagtggcaa gacctttcgt tggaaagatg gtgatatgga tctgtcaatg      600

aaaaaccgcg acttcagccc cttgatcggc cgcaccggca ttgagctggg caaaaccttc      660

tctggcaaag attggtctgt taccgcgcgt gcgggcactt cgtggcaatt tgatctgcta      720

aacaacggtg agactgtact gcgtgatgcg agtggcgaaa aacgtattaa aggtgaaaaa      780

gatagtagaa tgctattcaa cgtgggcatg aatgcgcaga tcaaagataa catgcgtttt      840

gggttggagt ttgaaaaatc cgcgttcggt aaatataatg ttgacaatgc tgtgaacgcg      900

aatttccgct acatgtttta a                                                921


<210> 823
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-CTLA-4 single chain antibody coding region (Heavy
      Chain linker Light Chain)"

<400> 823
atgcaagtgc aactggtaga gtccggtggg ggcgtggtgc agccgggtcg cagcctgcgt       60

ctgtcgtgcg cggcgagtgg ttttacgttt tcgagttata ctatgcactg ggttcgtcaa      120

gcgccgggca aaggcctgga atgggttact ttcatttctt acgatggtaa taataaatat      180

tatgcggatt ctgtgaaagg tcgctttact atttcgcgcg ataacagtaa aaacactctg      240

tatctgcaaa tgaattctct gcgtgcagag gatactgcta tctattactg cgcgcgtacg      300

ggctggttgg gcccgtttga ttattggggc caaggcactt tggttactgt gtcatcgggc      360

gggggctctg gcggtggttc aggtggtggc agtggtggtg gcgagatcgt gttgactcaa      420

tctccgggta ctctgtctct gtctccgggt gaacgcgcga ccctgtcttg ccgcgcttct      480

cagagtgttg gttcatcgta tctggcatgg tatcaacaga aaccgggtca agcgccgcgt      540

ctgctgattt acggtgcttt tagtcgcgca accgggattc cggatcgatt ttctggttca      600

ggttctggca ctgactttac tttgactatt agtcgtctgg aaccggagga cttcgcggtt      660

tattattgcc aacagtatgg ttcttctccg tggacctttg gtcaaggcac taaagttgaa      720

attaaataa                                                              729


<210> 824
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-CTLA-4 single chain antibody coding region (Light
      Chain linker Heavy Chain)"

<400> 824
atggagattg tactgaccca gagccctggt acattgtctt tgtcgcctgg tgaacgcgcg       60

actctgtctt gtcgtgcgtc tcagtctgtt ggtagttcgt atctggcgtg gtatcaacaa      120

aaaccgggcc aagctccgcg tctgctgatt tacggtgcat ttagccgcgc gactggcatt      180

ccggaccgct tttctgggtc tggctcaggt accgatttta ctctgactat ttcgcgtctg      240

gagccggagg atttcgcggt ttattactgc cagcaatatg gttctagtcc gtggaccttc      300

ggccaaggta ctaaagtgga aatcaaaggc gggggttcgg gtggtggctc tgggggtggc      360

tcgggcggtg ggcaggtgca actggttgag agtggtggcg gcgttgttca accgggccgc      420

tctctgcgcc tgtcgtgcgc tgcttctggc tttaccttta gctcttatac gatgcactgg      480

gttcgccaag ctccgggtaa aggtctggag tgggtgactt tcatttctta cgatggtaac      540

aacaaatatt atgctgattc tgttaaaggc cgttttacta tttctcgaga caatagcaaa      600

aacactctgt acctgcagat gaattctctg cgcgctgaag acaccgcgat ttattattgt      660

gcgcgcactg gttggctggg tccgtttgat tattggggtc agggcacgct ggttactgtt      720

agctcgtga                                                              729


<210> 825
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-1 single chain antibody coding region (Heavy
      Chain linker Light Chain)"

<400> 825
atgcaggtgc aattggtgga gtcgggtggc ggcgtggtgc aaccgggtcg tagcctgcgc       60

ctggattgta aagcgtcagg catcacgttt agcaattctg gcatgcactg ggtgcgtcaa      120

gcgccgggca aaggtctgga gtgggttgcg gtaatttggt acgatggttc taaacgctat      180

tacgcggata gtgtgaaagg tcgctttact atctctcgcg ataattctaa aaacaccctg      240

tttctgcaaa tgaattcgtt gcgtgcggaa gatactgcgg tatattattg tgctactaac      300

gatgattatt ggggtcaagg caccctggtg actgtttcga gcggcggtgg tagcggcggc      360

ggctctggtg gtggttctgg tggcggtgag attgtgctga ctcaaagccc ggcgaccctg      420

tctctgtcgc cgggtgaacg cgctactctg agttgccgtg cgtcgcaaag cgtgtcttct      480

tatctggcgt ggtaccaaca aaaaccgggt caagcgccgc gcctgctgat atatgatgct      540

agtaatcgtg caacgggtat tccggcacgc ttttcaggtt ctggcagcgg caccgatttc      600

actctgacta tctcgtcact ggagccggaa gactttgcgg tttattattg tcagcaatct      660

tctaattggc cgcgtacgtt tggtcagggc actaaagttg aaatcaaata a               711


<210> 826
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-1 single chain antibody coding region (Light
      Chain linker Heavy Chain)"

<400> 826
atggaaatcg ttttaacgca gtcgccggcg actctgtctt tgtcgcctgg tgaacgtgct       60

acgctgtctt gccgcgcgtc acagtctgtg tcgtcatatc tggcttggta ccaacagaaa      120

ccgggccaag ctccgcgcct gctgatttat gatgcgtcta atcgcgcgac cggcattccg      180

gcgcgttttt ctggctccgg ctctggcacc gactttactc tgactatttc gtctctggaa      240

ccggaagatt ttgcggtgta ctattgccag caatcttcta attggccgcg cacgtttggt      300

caaggtacca aggttgagat caaaggtggt ggctcgggcg gcggttcggg cggcggctca      360

ggtggtggcc aagttcagtt ggttgagtct ggcgggggcg tagtacaacc gggtcgttct      420

ttgcgtctgg attgcaaagc gagcggtatt acctttagca attcaggtat gcactgggtg      480

cgccaagcgc cgggcaaagg cctggaatgg gttgcggtga tttggtacga tggctcgaaa      540

cgttattatg ctgacagcgt taaaggtcgt tttactatta gccgtgataa ttccaaaaat      600

acgctgtttc tgcagatgaa tagcctgcgt gctgaagaca ctgcggttta ttactgtgct      660

actaatgatg attactgggg ccagggcacc ctggtgactg tgagttctta a               711


<210> 827
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-L1 single chain antibody coding region (Light
      Chain linker Heavy Chain)"

<400> 827
atggatattc agatgactca gagccctagc tcactgtctg cgtcagttgg cgatcgtgtg       60

actattacct gtcgcgctag tcaggatgtg tctacggcgg ttgcgtggta tcaacagaaa      120

ccgggcaaag ctccgaaact gttgatttat tcagcgtctt tcctgtattc gggtgtgcct      180

tctcgctttt cgggctctgg tagcggtact gattttacgc tgactattag ttcactgcaa      240

ccggaggact ttgcgactta ttattgccaa caatacctgt atcacccggc gacctttggt      300

caaggcacta aagtggaaat taaacgcggc ggcggcagcg gtggcggctc tggtggtggg      360

tctggtggtg gtgaggttca gctggttgag tctggtggtg gtctggttca acctgggggc      420

agcctgcgcc tgtcgtgcgc ggcgtctggt tttacgttct cagattcttg gattcactgg      480

gtacgtcaag ctccgggcaa aggtctggag tgggtggcgt ggatttctcc gtatggcggt      540

tcgacgtatt acgcggactc tgttaaaggg cgttttacga tctcagcgga tacttctaaa      600

aatactgcgt atctgcaaat gaattctctg cgagcggagg ataccgcggt gtattactgt      660

gctcgccgcc actggcctgg tggtttcgat tattggggtc aaggtaccct ggtgactgtt      720

tcgtcttaa                                                              729


<210> 828
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-L1 single chain antibody coding region (Heavy
      Chain linker Light Chain)"

<400> 828
atggaagttc agctggtgga gagtggtggc ggtctggtgc agccgggcgg ctctctgcgt       60

ctgagctgtg cggcgtctgg ctttacgttt tctgacagtt ggattcactg ggtgcgccaa      120

gcaccgggca aaggcctgga gtgggtggcg tggatttctc cgtatggcgg tagtacttat      180

tatgctgatt ctgtgaaagg ccgttttacc atttcggcgg acacttcaaa aaataccgcg      240

tatctgcaaa tgaatagcct gcgcgctgaa gacacggctg tttactactg tgctcgccgc      300

cactggccgg gcggtttcga ttattggggc caaggcactc tggtgactgt gagctctggc      360

ggcgggtcgg gtggcggttc tggcggtggc agtggcggtg gtgatattca aatgacccaa      420

tctccgtcgt ctctgagcgc gtctgtgggc gatcgtgtaa ccattacttg tcgtgcgtcg      480

caggatgtgt ctactgctgt ggcgtggtat cagcaaaaac cgggtaaagc tccgaaactg      540

ctgatttata gcgcttcttt tctgtatagt ggtgttccgt cacgttttag cggttcaggc      600

tctggtactg atttcacact gactatttct tctctgcaac cggaagattt cgcgacttat      660

tattgtcagc agtacttgta ccacccggca acttttggtc agggcactaa agttgaaatt      720

aaacgttaa                                                              729


<210> 829
<211> 1821
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-CTLA-4 single chain antibody coding region (Heavy
      Chain linker Light Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter"

<400> 829
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgccag      180

gtacaattag ttgagagcgg cggcggtgtg gttcaaccgg gccgtagtct gcgattgtct      240

tgtgctgcat ctggttttac tttcagttct tacacgatgc actgggttcg ccaagctccg      300

ggcaaaggcc tggagtgggt tacctttatt tcttacgatg gcaataataa gtattacgct      360

gattctgtga aaggtcgctt tactattagc cgagataact ctaaaaatac tctgtatctg      420

caaatgaatt ctctgcgtgc ggaagatact gcgatctatt attgtgcgcg tactggttgg      480

ctgggcccgt ttgattattg gggccaaggc acgctggtta ctgttagttc gggcggcggt      540

tctggtggcg gctctggtgg tggctctggc ggcggcgaga ttgtgctgac tcaatctccg      600

ggcacgctgt cactgtctcc gggtgaacgc gcgaccctgt cttgtcgcgc gagtcaaagt      660

gttggttctt cttatctggc ttggtatcag caaaagcctg gtcaagcgcc gcgtctgttg      720

atttatggcg cgttttcgcg cgcgactggc attccggacc gattttctgg ttctggttct      780

ggcactgatt tcactctgac catttcacgc ctggaaccgg aggattttgc ggtgtactat      840

tgccaacaat atggctcatc gccgtggacg tttggccaag gtactaaagt tgagattaaa      900

ttcaaagcgg aggctgacaa ggccgctgca gcaaaagctg actcctttat gaacgcgggt      960

tacaaaaact tcatgaccga ggtaaataat ctcaataaac gtatgggtga tctgcgcgac     1020

actaatgggg atgcaggcgc atgggcacgc attatgtctg gtgcaggttc ggcggatggc     1080

gggtattctg acaattacac tcatgttcag gtgggcttcg ataaaaaaca tgagctggac     1140

ggtgtggatc tgttcactgg cgtaaccatg acttatactg attcaagcgc agacagccac     1200

gcattttcag gtaaaacgaa atcagttggc ggcggtctgt atgcgagcgc actgttcgag     1260

agcggcgcct acattgatct aattggcaag tatattcacc atgataatga ttacacaggg     1320

aactttgcag gcctgggcac caaacactat aacacgcatt catggtacgc tggcgcagaa     1380

accggctata gataccacct gaccgaggaa acctttatcg aaccgcaagc ggaactggtt     1440

tacggtgcgg tcagtggcaa gacctttcgt tggaaagatg gtgatatgga tctgtcaatg     1500

aaaaaccgcg acttcagccc cttgatcggc cgcaccggca ttgagctggg caaaaccttc     1560

tctggcaaag attggtctgt taccgcgcgt gcgggcactt cgtggcaatt tgatctgcta     1620

aacaacggtg agactgtact gcgtgatgcg agtggcgaaa aacgtattaa aggtgaaaaa     1680

gatagtagaa tgctattcaa cgtgggcatg aatgcgcaga tcaaagataa catgcgtttt     1740

gggttggagt ttgaaaaatc cgcgttcggt aaatataatg ttgacaatgc tgtgaacgcg     1800

aatttccgct acatgtttta a                                               1821


<210> 830
<211> 1821
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-CTLA-4 single chain antibody coding region (Light
      Chain linker Heavy Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter"

<400> 830
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgcgaa      180

attgtactga cccagtcgcc tggtaccctg tctctgtcgc cgggtgaacg tgctaccctg      240

tcttgtcgtg cttcgcaatc ggttggctcg tcttatctgg catggtatca gcaaaaaccg      300

ggccaagcgc ctcgtctgct gatttatggc gcgttttctc gtgctacggg cattcctgat      360

cgtttttcgg gctctggctc tggtactgat tttacgctga ctatcagccg cttggaacct      420

gaagattttg cggtttatta ttgccaacaa tatggctctt ctccgtggac gtttggtcaa      480

ggcactaaag ttgaaattaa aggtggtggc tcgggcggtg gttctggtgg tggtagtggt      540

ggtggtcaag tgcagttggt tgaatcgggt ggcggtgttg tgcagccggg ccgttcgttg      600

cgtctgtctt gcgcagcgag tggtttcacc ttctcttctt atactatgca ctgggtgcgt      660

caagcacctg gcaaaggtct ggagtgggta acttttattt catacgatgg taataataaa      720

tattatgcag attctgttaa aggtcgcttt acgatttctc gcgataattc aaaaaatacg      780

ctgtatctgc agatgaattc gctgcgcgct gaggatactg cgatctacta ttgtgcgcgt      840

actggttggc tgggtccgtt tgattactgg ggccaaggta cgctggttac agtttcgtcg      900

ttcaaagcgg aggctgacaa ggccgctgca gcaaaagctg actcctttat gaacgcgggt      960

tacaaaaact tcatgaccga ggtaaataat ctcaataaac gtatgggtga tctgcgcgac     1020

actaatgggg atgcaggcgc atgggcacgc attatgtctg gtgcaggttc ggcggatggc     1080

gggtattctg acaattacac tcatgttcag gtgggcttcg ataaaaaaca tgagctggac     1140

ggtgtggatc tgttcactgg cgtaaccatg acttatactg attcaagcgc agacagccac     1200

gcattttcag gtaaaacgaa atcagttggc ggcggtctgt atgcgagcgc actgttcgag     1260

agcggcgcct acattgatct aattggcaag tatattcacc atgataatga ttacacaggg     1320

aactttgcag gcctgggcac caaacactat aacacgcatt catggtacgc tggcgcagaa     1380

accggctata gataccacct gaccgaggaa acctttatcg aaccgcaagc ggaactggtt     1440

tacggtgcgg tcagtggcaa gacctttcgt tggaaagatg gtgatatgga tctgtcaatg     1500

aaaaaccgcg acttcagccc cttgatcggc cgcaccggca ttgagctggg caaaaccttc     1560

tctggcaaag attggtctgt taccgcgcgt gcgggcactt cgtggcaatt tgatctgcta     1620

aacaacggtg agactgtact gcgtgatgcg agtggcgaaa aacgtattaa aggtgaaaaa     1680

gatagtagaa tgctattcaa cgtgggcatg aatgcgcaga tcaaagataa catgcgtttt     1740

gggttggagt ttgaaaaatc cgcgttcggt aaatataatg ttgacaatgc tgtgaacgcg     1800

aatttccgct acatgtttta a                                               1821


<210> 831
<211> 1803
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-1 single chain antibody coding region (Heavy
      Chain linker  Light Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter"

<400> 831
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgccaa      180

gtacaactgg ttgaatccgg cggaggagtg gtgcaaccgg gccgcagttt gcgtctggat      240

tgtaaagctt caggcatcac tttttctaat tctggtatgc actgggttcg ccaagctccg      300

ggtaaaggtc tggagtgggt tgcggtgatc tggtatgatg gttctaaacg atattatgcg      360

gatagtgtta agggtcgttt tactatttct cgtgataatt ctaagaacac cttgtttctg      420

cagatgaata gtctgcgcgc tgaggatact gcggtatatt attgtgcgac taatgacgat      480

tattggggcc aaggcacgct ggttaccgtg agctctggtg gtggttcggg tggtggttct      540

ggtggtggga gcggcggtgg cgagatcgtt ctgactcaaa gcccggcgac tctgagtctg      600

agtccgggtg aacgtgcgac tctgagctgc cgtgcgtctc agagtgtgtc gagttatctg      660

gcgtggtacc aacaaaaacc gggccaggcg ccgcgactgc tgatttatga tgcttctaat      720

cgtgcgactg gtattccggc gcgctttagc ggttctggct caggcactga cttcactctg      780

actatttctt cgctggaacc ggaagatttt gcggtgtact attgtcaaca atcatctaat      840

tggcctcgta cgttcggtca aggtacaaaa gtggagataa aattcaaagc ggaggctgac      900

aaggccgctg cagcaaaagc tgactccttt atgaacgcgg gttacaaaaa cttcatgacc      960

gaggtaaata atctcaataa acgtatgggt gatctgcgcg acactaatgg ggatgcaggc     1020

gcatgggcac gcattatgtc tggtgcaggt tcggcggatg gcgggtattc tgacaattac     1080

actcatgttc aggtgggctt cgataaaaaa catgagctgg acggtgtgga tctgttcact     1140

ggcgtaacca tgacttatac tgattcaagc gcagacagcc acgcattttc aggtaaaacg     1200

aaatcagttg gcggcggtct gtatgcgagc gcactgttcg agagcggcgc ctacattgat     1260

ctaattggca agtatattca ccatgataat gattacacag ggaactttgc aggcctgggc     1320

accaaacact ataacacgca ttcatggtac gctggcgcag aaaccggcta tagataccac     1380

ctgaccgagg aaacctttat cgaaccgcaa gcggaactgg tttacggtgc ggtcagtggc     1440

aagacctttc gttggaaaga tggtgatatg gatctgtcaa tgaaaaaccg cgacttcagc     1500

cccttgatcg gccgcaccgg cattgagctg ggcaaaacct tctctggcaa agattggtct     1560

gttaccgcgc gtgcgggcac ttcgtggcaa tttgatctgc taaacaacgg tgagactgta     1620

ctgcgtgatg cgagtggcga aaaacgtatt aaaggtgaaa aagatagtag aatgctattc     1680

aacgtgggca tgaatgcgca gatcaaagat aacatgcgtt ttgggttgga gtttgaaaaa     1740

tccgcgttcg gtaaatataa tgttgacaat gctgtgaacg cgaatttccg ctacatgttt     1800

taa                                                                   1803


<210> 832
<211> 1803
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-1 single chain antibody coding region (Light
      Chain linker Heavy Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter"

<400> 832
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgcgaa      180

atcgtgctga ctcagagtcc ggcgactctg tctctgagtc cgggcgaacg cgcgactctg      240

tcttgccgtg cgtctcaatc tgtgtcttca tacttggctt ggtaccaaca aaaaccgggc      300

caggcgccgc gactgttgat ttatgatgcg tcgaatcgcg cgactggcat tccggcgcgc      360

ttttcgggta gcggttctgg tactgatttt acgctgacta tctcttctct ggagcctgaa      420

gatttcgctg tttattactg ccaacagtct agtaattggc cgcgtacttt cggccagggc      480

actaaggtgg aaattaaagg tggcggctcg ggcggcggct cgggtggtgg ttctggtggt      540

ggccaagtgc aactggtgga aagtggcggc ggggtggtgc aaccgggccg ttctctgcgc      600

ctggattgta aagcttcagg cattactttt agcaactctg gtatgcactg ggttcgccaa      660

gctccgggca aaggcctgga atgggtggcg gttatttggt acgatggctc taaacgttat      720

tacgctgaca gtgttaaagg ccgctttacc atttctcgtg ataattctaa aaataccctg      780

tttctgcaaa tgaactcgct gcgcgcggaa gatactgctg tttactattg tgcgactaat      840

gatgattact ggggtcaagg taccctggtt accgtgtctt ctttcaaagc ggaggctgac      900

aaggccgctg cagcaaaagc tgactccttt atgaacgcgg gttacaaaaa cttcatgacc      960

gaggtaaata atctcaataa acgtatgggt gatctgcgcg acactaatgg ggatgcaggc     1020

gcatgggcac gcattatgtc tggtgcaggt tcggcggatg gcgggtattc tgacaattac     1080

actcatgttc aggtgggctt cgataaaaaa catgagctgg acggtgtgga tctgttcact     1140

ggcgtaacca tgacttatac tgattcaagc gcagacagcc acgcattttc aggtaaaacg     1200

aaatcagttg gcggcggtct gtatgcgagc gcactgttcg agagcggcgc ctacattgat     1260

ctaattggca agtatattca ccatgataat gattacacag ggaactttgc aggcctgggc     1320

accaaacact ataacacgca ttcatggtac gctggcgcag aaaccggcta tagataccac     1380

ctgaccgagg aaacctttat cgaaccgcaa gcggaactgg tttacggtgc ggtcagtggc     1440

aagacctttc gttggaaaga tggtgatatg gatctgtcaa tgaaaaaccg cgacttcagc     1500

cccttgatcg gccgcaccgg cattgagctg ggcaaaacct tctctggcaa agattggtct     1560

gttaccgcgc gtgcgggcac ttcgtggcaa tttgatctgc taaacaacgg tgagactgta     1620

ctgcgtgatg cgagtggcga aaaacgtatt aaaggtgaaa aagatagtag aatgctattc     1680

aacgtgggca tgaatgcgca gatcaaagat aacatgcgtt ttgggttgga gtttgaaaaa     1740

tccgcgttcg gtaaatataa tgttgacaat gctgtgaacg cgaatttccg ctacatgttt     1800

taa                                                                   1803


<210> 833
<211> 1821
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-L1 single chain antibody coding region (Light
      Chain linker Heavy Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter"

<400> 833
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgcgat      180

attcaaatga ctcaatctcc gagctctctg agtgcgtctg tgggtgatcg tgtgactatt      240

acttgtcgtg cgtctcaaga tgtttcaact gcggttgcgt ggtatcaaca gaaaccgggc      300

aaggcgccta agctgctgat ttattctgct tcgttcctgt acagcggtgt gccgtctcgt      360

ttctctggct ctggttcggg tactgatttc actctgacta tttcgagtct gcagccggaa      420

gattttgcga cttattattg tcaacaatat ctgtatcacc ctgcgacgtt tggtcaaggc      480

acgaaagttg aaattaaacg tggtggtggc tctggtggtg gcagcggtgg tgggtcgggt      540

ggcggtgaag ttcaactggt tgagtcaggt ggtggcctgg tgcaaccggg cggctctctg      600

cgcctgtctt gtgctgcgtc gggttttacg ttctctgata gctggattca ctgggtacgc      660

caggcaccgg gcaaaggtct ggaatgggta gcttggattt caccttatgg tggctctact      720

tattacgcgg atagcgtgaa aggtcgcttt actatttctg cggacactag caaaaatact      780

gcttacctgc aaatgaattc gctgcgtgct gaggatactg cagtgtatta ctgtgcgcgt      840

cgtcattggc ctggcggctt tgattattgg ggtcaaggta ctctggttac tgttagcagc      900

ttcaaagcgg aggctgacaa ggccgctgca gcaaaagctg actcctttat gaacgcgggt      960

tacaaaaact tcatgaccga ggtaaataat ctcaataaac gtatgggtga tctgcgcgac     1020

actaatgggg atgcaggcgc atgggcacgc attatgtctg gtgcaggttc ggcggatggc     1080

gggtattctg acaattacac tcatgttcag gtgggcttcg ataaaaaaca tgagctggac     1140

ggtgtggatc tgttcactgg cgtaaccatg acttatactg attcaagcgc agacagccac     1200

gcattttcag gtaaaacgaa atcagttggc ggcggtctgt atgcgagcgc actgttcgag     1260

agcggcgcct acattgatct aattggcaag tatattcacc atgataatga ttacacaggg     1320

aactttgcag gcctgggcac caaacactat aacacgcatt catggtacgc tggcgcagaa     1380

accggctata gataccacct gaccgaggaa acctttatcg aaccgcaagc ggaactggtt     1440

tacggtgcgg tcagtggcaa gacctttcgt tggaaagatg gtgatatgga tctgtcaatg     1500

aaaaaccgcg acttcagccc cttgatcggc cgcaccggca ttgagctggg caaaaccttc     1560

tctggcaaag attggtctgt taccgcgcgt gcgggcactt cgtggcaatt tgatctgcta     1620

aacaacggtg agactgtact gcgtgatgcg agtggcgaaa aacgtattaa aggtgaaaaa     1680

gatagtagaa tgctattcaa cgtgggcatg aatgcgcaga tcaaagataa catgcgtttt     1740

gggttggagt ttgaaaaatc cgcgttcggt aaatataatg ttgacaatgc tgtgaacgcg     1800

aatttccgct acatgtttta a                                               1821


<210> 834
<211> 1821
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-L1 single chain antibody coding region (Heavy
      Chain linker Light Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter"

<400> 834
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgcgaa      180

gtgcagctgg tggagtcagg tggaggcttg gtgcaaccgg gcggttcact gcgtctgtca      240

tgtgcggcgt ctgggtttac ttttagtgac tcttggattc actgggtgcg ccaggctccg      300

ggtaaaggcc tggaatgggt agcttggatt agtccttacg gtggctcgac ctattatgct      360

gattcggtaa agggtcgctt tactattagc gctgatactt ctaaaaatac tgcatacctg      420

cagatgaata gcctgcgcgc tgaggatact gctgtgtatt attgcgcgcg tcgccactgg      480

ccgggcggct ttgattattg gggccaaggt actctggtta ccgtgtctag tggcggtggt      540

agcggcggcg gctcaggtgg cggctcgggc ggtggcgaca ttcagatgac tcagtctccg      600

tcttctttgt cggcgagcgt gggcgatcgt gttaccatca cgtgtcgcgc gagccaagat      660

gtgtcgactg cggtggcttg gtatcaacaa aaaccgggta aagctccgaa actgctgatt      720

tatagtgcgt cttttttgta ttctggtgtt ccgtctcgtt tctctggctc aggtagcggt      780

actgatttta cgctgactat ttcttcactg caaccggaag attttgctac gtattattgt      840

caacaatatc tgtatcaccc ggcgacgttt ggtcagggta ctaaggtgga gataaaacgc      900

ttcaaagcgg aggctgacaa ggccgctgca gcaaaagctg actcctttat gaacgcgggt      960

tacaaaaact tcatgaccga ggtaaataat ctcaataaac gtatgggtga tctgcgcgac     1020

actaatgggg atgcaggcgc atgggcacgc attatgtctg gtgcaggttc ggcggatggc     1080

gggtattctg acaattacac tcatgttcag gtgggcttcg ataaaaaaca tgagctggac     1140

ggtgtggatc tgttcactgg cgtaaccatg acttatactg attcaagcgc agacagccac     1200

gcattttcag gtaaaacgaa atcagttggc ggcggtctgt atgcgagcgc actgttcgag     1260

agcggcgcct acattgatct aattggcaag tatattcacc atgataatga ttacacaggg     1320

aactttgcag gcctgggcac caaacactat aacacgcatt catggtacgc tggcgcagaa     1380

accggctata gataccacct gaccgaggaa acctttatcg aaccgcaagc ggaactggtt     1440

tacggtgcgg tcagtggcaa gacctttcgt tggaaagatg gtgatatgga tctgtcaatg     1500

aaaaaccgcg acttcagccc cttgatcggc cgcaccggca ttgagctggg caaaaccttc     1560

tctggcaaag attggtctgt taccgcgcgt gcgggcactt cgtggcaatt tgatctgcta     1620

aacaacggtg agactgtact gcgtgatgcg agtggcgaaa aacgtattaa aggtgaaaaa     1680

gatagtagaa tgctattcaa cgtgggcatg aatgcgcaga tcaaagataa catgcgtttt     1740

gggttggagt ttgaaaaatc cgcgttcggt aaatataatg ttgacaatgc tgtgaacgcg     1800

aatttccgct acatgtttta a                                               1821


<210> 835
<211> 885
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-CTLA-4 single chain antibody coding region (Heavy
      Chain linker Light Chain) for type I hemolysin secretion,
      including HlyA tag"

<400> 835
atgcaggtac aattagttga gagcggcggc ggtgtggttc aaccgggccg tagtctgcga       60

ttgtcttgtg ctgcatctgg ttttactttc agttcttaca cgatgcactg ggttcgccaa      120

gctccgggca aaggcctgga gtgggttacc tttatttctt acgatggcaa taataagtat      180

tacgctgatt ctgtgaaagg tcgctttact attagccgag ataactctaa aaatactctg      240

tatctgcaaa tgaattctct gcgtgcggaa gatactgcga tctattattg tgcgcgtact      300

ggttggctgg gcccgtttga ttattggggc caaggcacgc tggttactgt tagttcgggc      360

ggcggttctg gtggcggctc tggtggtggc tctggcggcg gcgagattgt gctgactcaa      420

tctccgggca cgctgtcact gtctccgggt gaacgcgcga ccctgtcttg tcgcgcgagt      480

caaagtgttg gttcttctta tctggcttgg tatcagcaaa agcctggtca agcgccgcgt      540

ctgttgattt atggcgcgtt ttcgcgcgcg actggcattc cggaccgatt ttctggttct      600

ggttctggca ctgatttcac tctgaccatt tcacgcctgg aaccggagga ttttgcggtg      660

tactattgcc aacaatatgg ctcatcgccg tggacgtttg gccaaggtac taaagttgag      720

attaaactta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtaatttt      780

gatgttaaag aggaaagagc tgcagcttct ttattgcagt tgtccggtaa tgccagtgat      840

ttttcatatg gacggaactc aataactttg acagcatcag cataa                      885


<210> 836
<211> 885
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-CTLA-4 single chain antibody coding region (Light
      Chain linker Heavy Chain) for type I hemolysin secretion,
      including HlyA tag"

<400> 836
atggaaattg tactgaccca gtcgcctggt accctgtctc tgtcgccggg tgaacgtgct       60

accctgtctt gtcgtgcttc gcaatcggtt ggctcgtctt atctggcatg gtatcagcaa      120

aaaccgggcc aagcgcctcg tctgctgatt tatggcgcgt tttctcgtgc tacgggcatt      180

cctgatcgtt tttcgggctc tggctctggt actgatttta cgctgactat cagccgcttg      240

gaacctgaag attttgcggt ttattattgc caacaatatg gctcttctcc gtggacgttt      300

ggtcaaggca ctaaagttga aattaaaggt ggtggctcgg gcggtggttc tggtggtggt      360

agtggtggtg gtcaagtgca gttggttgaa tcgggtggcg gtgttgtgca gccgggccgt      420

tcgttgcgtc tgtcttgcgc agcgagtggt ttcaccttct cttcttatac tatgcactgg      480

gtgcgtcaag cacctggcaa aggtctggag tgggtaactt ttatttcata cgatggtaat      540

aataaatatt atgcagattc tgttaaaggt cgctttacga tttctcgcga taattcaaaa      600

aatacgctgt atctgcagat gaattcgctg cgcgctgagg atactgcgat ctactattgt      660

gcgcgtactg gttggctggg tccgtttgat tactggggcc aaggtacgct ggttacagtt      720

tcgtcgctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtaatttt      780

gatgttaaag aggaaagagc tgcagcttct ttattgcagt tgtccggtaa tgccagtgat      840

ttttcatatg gacggaactc aataactttg acagcatcag cataa                      885


<210> 837
<211> 867
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-1 single chain antibody coding region (Heavy
      Chain linker Light Chain) for type I hemolysin secretion,
      including HlyA tag"

<400> 837
atgcaagtac aactggttga atccggcgga ggagtggtgc aaccgggccg cagtttgcgt       60

ctggattgta aagcttcagg catcactttt tctaattctg gtatgcactg ggttcgccaa      120

gctccgggta aaggtctgga gtgggttgcg gtgatctggt atgatggttc taaacgatat      180

tatgcggata gtgttaaggg tcgttttact atttctcgtg ataattctaa gaacaccttg      240

tttctgcaga tgaatagtct gcgcgctgag gatactgcgg tatattattg tgcgactaat      300

gacgattatt ggggccaagg cacgctggtt accgtgagct ctggtggtgg ttcgggtggt      360

ggttctggtg gtgggagcgg cggtggcgag atcgttctga ctcaaagccc ggcgactctg      420

agtctgagtc cgggtgaacg tgcgactctg agctgccgtg cgtctcagag tgtgtcgagt      480

tatctggcgt ggtaccaaca aaaaccgggc caggcgccgc gactgctgat ttatgatgct      540

tctaatcgtg cgactggtat tccggcgcgc tttagcggtt ctggctcagg cactgacttc      600

actctgacta tttcttcgct ggaaccggaa gattttgcgg tgtactattg tcaacaatca      660

tctaattggc ctcgtacgtt cggtcaaggt acaaaagtgg agataaaact taatccatta      720

attaatgaaa tcagcaaaat catttcagct gcaggtaatt ttgatgttaa agaggaaaga      780

gctgcagctt ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac      840

tcaataactt tgacagcatc agcataa                                          867


<210> 838
<211> 867
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-1 single chain antibody coding region (Light
      Chain linker Heavy Chain) for type I hemolysin secretion,
      including HlyA tag"

<400> 838
atggaaatcg tgctgactca gagtccggcg actctgtctc tgagtccggg cgaacgcgcg       60

actctgtctt gccgtgcgtc tcaatctgtg tcttcatact tggcttggta ccaacaaaaa      120

ccgggccagg cgccgcgact gttgatttat gatgcgtcga atcgcgcgac tggcattccg      180

gcgcgctttt cgggtagcgg ttctggtact gattttacgc tgactatctc ttctctggag      240

cctgaagatt tcgctgttta ttactgccaa cagtctagta attggccgcg tactttcggc      300

cagggcacta aggtggaaat taaaggtggc ggctcgggcg gcggctcggg tggtggttct      360

ggtggtggcc aagtgcaact ggtggaaagt ggcggcgggg tggtgcaacc gggccgttct      420

ctgcgcctgg attgtaaagc ttcaggcatt acttttagca actctggtat gcactgggtt      480

cgccaagctc cgggcaaagg cctggaatgg gtggcggtta tttggtacga tggctctaaa      540

cgttattacg ctgacagtgt taaaggccgc tttaccattt ctcgtgataa ttctaaaaat      600

accctgtttc tgcaaatgaa ctcgctgcgc gcggaagata ctgctgttta ctattgtgcg      660

actaatgatg attactgggg tcaaggtacc ctggttaccg tgtcttctct taatccatta      720

attaatgaaa tcagcaaaat catttcagct gcaggtaatt ttgatgttaa agaggaaaga      780

gctgcagctt ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac      840

tcaataactt tgacagcatc agcataa                                          867


<210> 839
<211> 885
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-L1 single chain antibody coding region (Light
      Chain linker Heavy Chain) for type I hemolysin secretion,
      including HlyA tag"

<400> 839
atggatattc aaatgactca atctccgagc tctctgagtg cgtctgtggg tgatcgtgtg       60

actattactt gtcgtgcgtc tcaagatgtt tcaactgcgg ttgcgtggta tcaacagaaa      120

ccgggcaagg cgcctaagct gctgatttat tctgcttcgt tcctgtacag cggtgtgccg      180

tctcgtttct ctggctctgg ttcgggtact gatttcactc tgactatttc gagtctgcag      240

ccggaagatt ttgcgactta ttattgtcaa caatatctgt atcaccctgc gacgtttggt      300

caaggcacga aagttgaaat taaacgtggt ggtggctctg gtggtggcag cggtggtggg      360

tcgggtggcg gtgaagttca actggttgag tcaggtggtg gcctggtgca accgggcggc      420

tctctgcgcc tgtcttgtgc tgcgtcgggt tttacgttct ctgatagctg gattcactgg      480

gtacgccagg caccgggcaa aggtctggaa tgggtagctt ggatttcacc ttatggtggc      540

tctacttatt acgcggatag cgtgaaaggt cgctttacta tttctgcgga cactagcaaa      600

aatactgctt acctgcaaat gaattcgctg cgtgctgagg atactgcagt gtattactgt      660

gcgcgtcgtc attggcctgg cggctttgat tattggggtc aaggtactct ggttactgtt      720

agcagcctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtaatttt      780

gatgttaaag aggaaagagc tgcagcttct ttattgcagt tgtccggtaa tgccagtgat      840

ttttcatatg gacggaactc aataactttg acagcatcag cataa                      885


<210> 840
<211> 885
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-PD-L1 single chain antibody coding region (Heavy
      Chain linker Light Chain) for type I hemolysin secretion,
      including HlyA tag"

<400> 840
atggaagtgc agctggtgga gtcaggtgga ggcttggtgc aaccgggcgg ttcactgcgt       60

ctgtcatgtg cggcgtctgg gtttactttt agtgactctt ggattcactg ggtgcgccag      120

gctccgggta aaggcctgga atgggtagct tggattagtc cttacggtgg ctcgacctat      180

tatgctgatt cggtaaaggg tcgctttact attagcgctg atacttctaa aaatactgca      240

tacctgcaga tgaatagcct gcgcgctgag gatactgctg tgtattattg cgcgcgtcgc      300

cactggccgg gcggctttga ttattggggc caaggtactc tggttaccgt gtctagtggc      360

ggtggtagcg gcggcggctc aggtggcggc tcgggcggtg gcgacattca gatgactcag      420

tctccgtctt ctttgtcggc gagcgtgggc gatcgtgtta ccatcacgtg tcgcgcgagc      480

caagatgtgt cgactgcggt ggcttggtat caacaaaaac cgggtaaagc tccgaaactg      540

ctgatttata gtgcgtcttt tttgtattct ggtgttccgt ctcgtttctc tggctcaggt      600

agcggtactg attttacgct gactatttct tcactgcaac cggaagattt tgctacgtat      660

tattgtcaac aatatctgta tcacccggcg acgtttggtc agggtactaa ggtggagata      720

aaacgcctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtaatttt      780

gatgttaaag aggaaagagc tgcagcttct ttattgcagt tgtccggtaa tgccagtgat      840

ttttcatatg gacggaactc aataactttg acagcatcag cataa                      885


<210> 841
<211> 159
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="C terminal HlyA secretion Tag"

<400> 841
cttaatccat taattaatga aatcagcaaa atcatttcag ctgcaggtaa ttttgatgtt       60

aaagaggaaa gagctgcagc ttctttattg cagttgtccg gtaatgccag tgatttttca      120

tatggacgga actcaataac tttgacagca tcagcataa                             159


<210> 842
<211> 2124
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="HlyB coding sequence"

<400> 842
atggattctt gtcataaaat tgattatggg ttatacgccc tggagatttt agcccaatac       60

cataacgtct ctgttaaccc ggaagaaatt aaacatagat ttgacacaga cgggactggt      120

ctgggattaa cgtcatggtt gcttgctgcg aaatctttag aactaaaggt aaaacaggta      180

aaaaaaacaa ttgaccgatt aaactttatt tctttgcccg cattagtctg gagagaggat      240

ggacgtcatt ttattctgac taaagtcagt aaagaagcaa acagatatct tatttttgat      300

ctggagcaac gaaatccccg tgttctcgaa cagtctgagt ttgaggcgtt atatcagggg      360

catattattc ttattgcttc ccgttcttct gttaccggga aactggcaaa atttgacttt      420

acctggttta tccctgccat tataaaatac agaaaaatat ttattgaaac ccttgttgta      480

tctgtttttt tacaattatt tgcattaata accccccttt tttttcaggt ggttatggac      540

aaagtattag tacacagggg gttttcaacc cttaatgtta ttactgtcgc attatctgtt      600

gtggtggtgt ttgagattat actcagcggt ttaagaactt acatttttgc acatagtaca      660

agtcggattg atgttgagtt gggtgccaaa ctcttccggc atttactggc gctaccgatc      720

tcttattttg agagtcgtcg tgttggtgat actgttgcca gggtaagaga attagaccag      780

atccgtaatt ttctgacagg acaggcatta acatctgttc tggacttatt attttcattc      840

atattttttg cggtaatgtg gtattacagc ccaaagctta ctctggtgat cttattttcg      900

ctgccctgtt atgctgcatg gtctgttttt attagcccca ttttgcgacg tcgccttgat      960

gataagtttt cacggaatgc ggataatcaa tctttcctgg tggaatcagt cacggcgatt     1020

aacactataa aagctatggc agtctcacct cagatgacga acatatggga caaacaattg     1080

gcaggatatg ttgctgcagg ctttaaagtg acagtattag ccaccattgg tcaacaagga     1140

atacagttaa tacaaaagac tgttatgatc atcaacctgt ggttgggagc acacctggtt     1200

atttccgggg atttaagtat tggtcagtta attgctttta atatgcttgc tggtcagatt     1260

gttgcaccgg ttattcgcct tgcacaaatc tggcaggatt tccagcaggt tggtatatca     1320

gttacccgcc ttggtgatgt gcttaactct ccaactgaaa gttatcatgg gaaactggca     1380

ttaccggaaa ttaatggtaa tatcactttt cgtaatatcc ggtttcgcta taagcctgac     1440

tctccggtta ttttagataa tatcaatctc agtattaagc agggggaggt tattggtatt     1500

gtcggacgtt ctggttcagg aaaaagcaca ttaactaaat taattcaacg tttttatatt     1560

cctgaaaatg gccaggtctt aattgatgga catgatcttg cgttggccga tcctaactgg     1620

ttacgtcgtc aggtgggggt tgtgttgcag gacaatgtgc tgcttaatcg cagtattatt     1680

gataatatct cactggctaa tcctggtatg tccgtcgaaa aagttattta tgcagcgaaa     1740

ttagcaggcg ctcatgattt tatttctgaa ttgcgtgagg ggtataacac cattgtcggg     1800

gaacaggggg caggattatc cggaggtcaa cgtcaacgca tcgcaattgc aagggcgctg     1860

gtgaacaacc ctaaaatact tatttttgat gaagcaacca gtgctctgga ttatgagtcg     1920

gagcatatca tcatgcgcaa tatgcacaaa atatgtaagg gcagaacggt tataatcatt     1980

gctcatcgtc tgtctacagt aaaaaatgca gaccgcatta ttgtcatgga aaaagggaaa     2040

attgttgaac agggtaaaca taaggaactg ctttctgaac cggaaagttt atacagttac     2100

ttatatcagt tacagtcaga ctaa                                            2124


<210> 843
<211> 1437
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="HlyD coding sequence"

<400> 843
atgaaaacat ggttaatggg gttcagcgag ttcctgttgc gctataaact tgtctggagt       60

gaaacatgga aaatccggaa gcaattagat actccggtac gtgaaaagga cgaaaatgaa      120

ttcttacccg ctcatctgga attaattgaa acgccggtat ccagacggcc gcgtctggtt      180

gcttatttta ttatggggtt tctggttatt gctgtcattt tatctgtttt aggtcaggtg      240

gaaattgttg ccactgcaaa tgggaaatta acactaagtg ggcgcagcaa agaaattaaa      300

cctattgaaa actcaatagt taaagaaatt atcgtaaaag aaggagagtc agtccggaaa      360

ggggatgtgt tattaaagct tacagcactg ggagctgaag ctgatacgtt aaaaacacag      420

tcatcactgt tacagaccag gctggaacaa actcggtatc aaattctgag caggtcaatt      480

gaattaaata aactacctga actgaagctt cctgatgagc cttattttca gaatgtatct      540

gaagaggaag tactgcgttt aacttctttg ataaaagaac agttttccac atggcaaaat      600

cagaagtatc aaaaagaact gaatctggat aagaaaagag cagagcgatt aacaatactt      660

gcccgtataa accgttatga aaatttatcg agagttgaaa aaagccgtct ggatgatttc      720

aggagtttat tgcataaaca ggcaattgca aaacatgctg tacttgagca ggagaataaa      780

tatgtcgagg cagcaaatga attacgggtt tataaatcgc aactggagca aattgagagt      840

gagatattgt ctgcaaaaga agaatatcag cttgtcacgc agctttttaa aaatgaaatt      900

ttagacaagc taagacaaac aacagacaac attgagttat taactctgga gttagagaaa      960

aatgaagagc gtcaacaggc ttcagtaatc agggcccctg tttcgggaaa agttcagcaa     1020

ctgaaggttc atactgaagg tggggttgtt acaacagcgg aaacactgat ggtcatcgtt     1080

ccggaagatg acacgctgga ggttactgct ctggtacaaa ataaagatat tggttttatt     1140

aacgtcgggc agaatgccat cattaaagtg gaggcctttc cttacacccg atatggttat     1200

ctggtgggta aggtgaaaaa tataaattta gatgcaatag aagaccagaa actgggactc     1260

gtttttaatg tcattgtttc tgttgaagag aatgatttgt caaccgggaa taagcacatt     1320

ccattaagct cgggtatggc tgtcactgca gaaataaaga ctggaatgcg aagcgtaatc     1380

agctatcttc ttagtcctct ggaagagtct gtaacagaaa gtttacatga gcgttaa        1437


<210> 844
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-CTLA-4 Heavy"

<400> 844
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 845
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-CTLA-4 Light"

<400> 845
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 846
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-PD-1 Heavy"

<400> 846
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn 
            20                  25                  30          


Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210> 847
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-PD-1 Light"

<400> 847
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 848
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-PD-L1 Light"

<400> 848
Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr 
            20                  25                  30          


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro 
                85                  90                  95      


Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210> 849
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-PD-L1 Heavy"

<400> 849
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 850
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Linker"

<400> 850
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15  


<210> 851
<211> 59
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="N Terminal Secretion Tag For Type V Auto-secreter
      Secretion"

<400> 851
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg 
    50                  55                  


<210> 852
<211> 162
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="C Terminal Secretion Tag For Type V Auto-secreter
      Secretion"

<400> 852
Phe Lys Ala Glu Ala Asp Lys Ala Ala Ala Ala Lys Ala Asp Ser Phe 
1               5                   10                  15      


Met Asn Ala Gly Tyr Lys Asn Phe Met Thr Glu Val Asn Asn Leu Asn 
            20                  25                  30          


Lys Arg Met Gly Asp Leu Arg Asp Thr Asn Gly Asp Ala Gly Ala Trp 
        35                  40                  45              


Ala Arg Ile Met Ser Gly Ala Gly Ser Ala Asp Gly Gly Tyr Ser Asp 
    50                  55                  60                  


Asn Tyr Thr His Val Gln Val Gly Phe Asp Lys Lys His Glu Leu Asp 
65                  70                  75                  80  


Gly Val Asp Leu Phe Thr Gly Val Thr Met Thr Tyr Thr Asp Ser Ser 
                85                  90                  95      


Ala Asp Ser His Ala Phe Ser Gly Lys Thr Lys Ser Val Gly Gly Gly 
            100                 105                 110         


Leu Tyr Ala Ser Ala Leu Phe Glu Ser Gly Ala Tyr Ile Asp Leu Ile 
        115                 120                 125             


Gly Lys Tyr Ile His His Asp Asn Asp Tyr Thr Gly Asn Phe Ala Gly 
    130                 135                 140                 


Leu Gly Thr Lys His Tyr Asn Thr His Ser Trp Tyr Ala Gly Ala Glu 
145                 150                 155                 160 


Thr Gly 
        


<210> 853
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="C-Terminal HlyA Secretion Tag"

<400> 853
Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly 
1               5                   10                  15      


Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu Gln Leu 
            20                  25                  30          


Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu 
        35                  40                  45              


Thr Ala Ser Ala 
    50          


<210> 854
<211> 707
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="HlyB"

<400> 854
Met Asp Ser Cys His Lys Ile Asp Tyr Gly Leu Tyr Ala Leu Glu Ile 
1               5                   10                  15      


Leu Ala Gln Tyr His Asn Val Ser Val Asn Pro Glu Glu Ile Lys His 
            20                  25                  30          


Arg Phe Asp Thr Asp Gly Thr Gly Leu Gly Leu Thr Ser Trp Leu Leu 
        35                  40                  45              


Ala Ala Lys Ser Leu Glu Leu Lys Val Lys Gln Val Lys Lys Thr Ile 
    50                  55                  60                  


Asp Arg Leu Asn Phe Ile Ser Leu Pro Ala Leu Val Trp Arg Glu Asp 
65                  70                  75                  80  


Gly Arg His Phe Ile Leu Thr Lys Val Ser Lys Glu Ala Asn Arg Tyr 
                85                  90                  95      


Leu Ile Phe Asp Leu Glu Gln Arg Asn Pro Arg Val Leu Glu Gln Ser 
            100                 105                 110         


Glu Phe Glu Ala Leu Tyr Gln Gly His Ile Ile Leu Ile Ala Ser Arg 
        115                 120                 125             


Ser Ser Val Thr Gly Lys Leu Ala Lys Phe Asp Phe Thr Trp Phe Ile 
    130                 135                 140                 


Pro Ala Ile Ile Lys Tyr Arg Lys Ile Phe Ile Glu Thr Leu Val Val 
145                 150                 155                 160 


Ser Val Phe Leu Gln Leu Phe Ala Leu Ile Thr Pro Leu Phe Phe Gln 
                165                 170                 175     


Val Val Met Asp Lys Val Leu Val His Arg Gly Phe Ser Thr Leu Asn 
            180                 185                 190         


Val Ile Thr Val Ala Leu Ser Val Val Val Val Phe Glu Ile Ile Leu 
        195                 200                 205             


Ser Gly Leu Arg Thr Tyr Ile Phe Ala His Ser Thr Ser Arg Ile Asp 
    210                 215                 220                 


Val Glu Leu Gly Ala Lys Leu Phe Arg His Leu Leu Ala Leu Pro Ile 
225                 230                 235                 240 


Ser Tyr Phe Glu Ser Arg Arg Val Gly Asp Thr Val Ala Arg Val Arg 
                245                 250                 255     


Glu Leu Asp Gln Ile Arg Asn Phe Leu Thr Gly Gln Ala Leu Thr Ser 
            260                 265                 270         


Val Leu Asp Leu Leu Phe Ser Phe Ile Phe Phe Ala Val Met Trp Tyr 
        275                 280                 285             


Tyr Ser Pro Lys Leu Thr Leu Val Ile Leu Phe Ser Leu Pro Cys Tyr 
    290                 295                 300                 


Ala Ala Trp Ser Val Phe Ile Ser Pro Ile Leu Arg Arg Arg Leu Asp 
305                 310                 315                 320 


Asp Lys Phe Ser Arg Asn Ala Asp Asn Gln Ser Phe Leu Val Glu Ser 
                325                 330                 335     


Val Thr Ala Ile Asn Thr Ile Lys Ala Met Ala Val Ser Pro Gln Met 
            340                 345                 350         


Thr Asn Ile Trp Asp Lys Gln Leu Ala Gly Tyr Val Ala Ala Gly Phe 
        355                 360                 365             


Lys Val Thr Val Leu Ala Thr Ile Gly Gln Gln Gly Ile Gln Leu Ile 
    370                 375                 380                 


Gln Lys Thr Val Met Ile Ile Asn Leu Trp Leu Gly Ala His Leu Val 
385                 390                 395                 400 


Ile Ser Gly Asp Leu Ser Ile Gly Gln Leu Ile Ala Phe Asn Met Leu 
                405                 410                 415     


Ala Gly Gln Ile Val Ala Pro Val Ile Arg Leu Ala Gln Ile Trp Gln 
            420                 425                 430         


Asp Phe Gln Gln Val Gly Ile Ser Val Thr Arg Leu Gly Asp Val Leu 
        435                 440                 445             


Asn Ser Pro Thr Glu Ser Tyr His Gly Lys Leu Ala Leu Pro Glu Ile 
    450                 455                 460                 


Asn Gly Asn Ile Thr Phe Arg Asn Ile Arg Phe Arg Tyr Lys Pro Asp 
465                 470                 475                 480 


Ser Pro Val Ile Leu Asp Asn Ile Asn Leu Ser Ile Lys Gln Gly Glu 
                485                 490                 495     


Val Ile Gly Ile Val Gly Arg Ser Gly Ser Gly Lys Ser Thr Leu Thr 
            500                 505                 510         


Lys Leu Ile Gln Arg Phe Tyr Ile Pro Glu Asn Gly Gln Val Leu Ile 
        515                 520                 525             


Asp Gly His Asp Leu Ala Leu Ala Asp Pro Asn Trp Leu Arg Arg Gln 
    530                 535                 540                 


Val Gly Val Val Leu Gln Asp Asn Val Leu Leu Asn Arg Ser Ile Ile 
545                 550                 555                 560 


Asp Asn Ile Ser Leu Ala Asn Pro Gly Met Ser Val Glu Lys Val Ile 
                565                 570                 575     


Tyr Ala Ala Lys Leu Ala Gly Ala His Asp Phe Ile Ser Glu Leu Arg 
            580                 585                 590         


Glu Gly Tyr Asn Thr Ile Val Gly Glu Gln Gly Ala Gly Leu Ser Gly 
        595                 600                 605             


Gly Gln Arg Gln Arg Ile Ala Ile Ala Arg Ala Leu Val Asn Asn Pro 
    610                 615                 620                 


Lys Ile Leu Ile Phe Asp Glu Ala Thr Ser Ala Leu Asp Tyr Glu Ser 
625                 630                 635                 640 


Glu His Ile Ile Met Arg Asn Met His Lys Ile Cys Lys Gly Arg Thr 
                645                 650                 655     


Val Ile Ile Ile Ala His Arg Leu Ser Thr Val Lys Asn Ala Asp Arg 
            660                 665                 670         


Ile Ile Val Met Glu Lys Gly Lys Ile Val Glu Gln Gly Lys His Lys 
        675                 680                 685             


Glu Leu Leu Ser Glu Pro Glu Ser Leu Tyr Ser Tyr Leu Tyr Gln Leu 
    690                 695                 700                 


Gln Ser Asp 
705         


<210> 855
<211> 478
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="HlyD"

<400> 855
Met Lys Thr Trp Leu Met Gly Phe Ser Glu Phe Leu Leu Arg Tyr Lys 
1               5                   10                  15      


Leu Val Trp Ser Glu Thr Trp Lys Ile Arg Lys Gln Leu Asp Thr Pro 
            20                  25                  30          


Val Arg Glu Lys Asp Glu Asn Glu Phe Leu Pro Ala His Leu Glu Leu 
        35                  40                  45              


Ile Glu Thr Pro Val Ser Arg Arg Pro Arg Leu Val Ala Tyr Phe Ile 
    50                  55                  60                  


Met Gly Phe Leu Val Ile Ala Val Ile Leu Ser Val Leu Gly Gln Val 
65                  70                  75                  80  


Glu Ile Val Ala Thr Ala Asn Gly Lys Leu Thr Leu Ser Gly Arg Ser 
                85                  90                  95      


Lys Glu Ile Lys Pro Ile Glu Asn Ser Ile Val Lys Glu Ile Ile Val 
            100                 105                 110         


Lys Glu Gly Glu Ser Val Arg Lys Gly Asp Val Leu Leu Lys Leu Thr 
        115                 120                 125             


Ala Leu Gly Ala Glu Ala Asp Thr Leu Lys Thr Gln Ser Ser Leu Leu 
    130                 135                 140                 


Gln Thr Arg Leu Glu Gln Thr Arg Tyr Gln Ile Leu Ser Arg Ser Ile 
145                 150                 155                 160 


Glu Leu Asn Lys Leu Pro Glu Leu Lys Leu Pro Asp Glu Pro Tyr Phe 
                165                 170                 175     


Gln Asn Val Ser Glu Glu Glu Val Leu Arg Leu Thr Ser Leu Ile Lys 
            180                 185                 190         


Glu Gln Phe Ser Thr Trp Gln Asn Gln Lys Tyr Gln Lys Glu Leu Asn 
        195                 200                 205             


Leu Asp Lys Lys Arg Ala Glu Arg Leu Thr Ile Leu Ala Arg Ile Asn 
    210                 215                 220                 


Arg Tyr Glu Asn Leu Ser Arg Val Glu Lys Ser Arg Leu Asp Asp Phe 
225                 230                 235                 240 


Arg Ser Leu Leu His Lys Gln Ala Ile Ala Lys His Ala Val Leu Glu 
                245                 250                 255     


Gln Glu Asn Lys Tyr Val Glu Ala Ala Asn Glu Leu Arg Val Tyr Lys 
            260                 265                 270         


Ser Gln Leu Glu Gln Ile Glu Ser Glu Ile Leu Ser Ala Lys Glu Glu 
        275                 280                 285             


Tyr Gln Leu Val Thr Gln Leu Phe Lys Asn Glu Ile Leu Asp Lys Leu 
    290                 295                 300                 


Arg Gln Thr Thr Asp Asn Ile Glu Leu Leu Thr Leu Glu Leu Glu Lys 
305                 310                 315                 320 


Asn Glu Glu Arg Gln Gln Ala Ser Val Ile Arg Ala Pro Val Ser Gly 
                325                 330                 335     


Lys Val Gln Gln Leu Lys Val His Thr Glu Gly Gly Val Val Thr Thr 
            340                 345                 350         


Ala Glu Thr Leu Met Val Ile Val Pro Glu Asp Asp Thr Leu Glu Val 
        355                 360                 365             


Thr Ala Leu Val Gln Asn Lys Asp Ile Gly Phe Ile Asn Val Gly Gln 
    370                 375                 380                 


Asn Ala Ile Ile Lys Val Glu Ala Phe Pro Tyr Thr Arg Tyr Gly Tyr 
385                 390                 395                 400 


Leu Val Gly Lys Val Lys Asn Ile Asn Leu Asp Ala Ile Glu Asp Gln 
                405                 410                 415     


Lys Leu Gly Leu Val Phe Asn Val Ile Val Ser Val Glu Glu Asn Asp 
            420                 425                 430         


Leu Ser Thr Gly Asn Lys His Ile Pro Leu Ser Ser Gly Met Ala Val 
        435                 440                 445             


Thr Ala Glu Ile Lys Thr Gly Met Arg Ser Val Ile Ser Tyr Leu Leu 
    450                 455                 460                 


Ser Pro Leu Glu Glu Ser Val Thr Glu Ser Leu His Glu Arg 
465                 470                 475             


<210> 856
<211> 213
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="PfnrS"

<400> 856
ggtaccagtt gttcttattg gtggtgttgc tttatggttg catcgtagta aatggttgta       60

acaaaagcaa tttttccggc tgtctgtata caaaaacgcc gtaaagtttg agcgaagtca      120

ataaactctc tacccattca gggcaatatc tctcttggat ccaaagtgaa ctctagaaat      180

aattttgttt aactttaaga aggagatata cat                                   213


<210> 857
<211> 1455
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="PfnrS-nupC"

<400> 857
ggtaccagtt gttcttattg gtggtgttgc tttatggttg catcgtagta aatggttgta       60

acaaaagcaa tttttccggc tgtctgtata caaaaacgcc gtaaagtttg agcgaagtca      120

ataaactctc tacccattca gggcaatatc tctcttggat ccaaagtgaa ctctagaaat      180

aattttgttt aactttaaga aggagatata catgtgcacg gaaatttaac ctgcctcata      240

tttggagcaa atatggaccg cgtccttcat tttgtactgg cacttgccgt tgttgcgatt      300

ctcgcactgc tggtaagcag cgaccgcaaa aaaattcgta tccgttatgt tattcaactg      360

cttgttatcg aagtgttact ggcgtggttc ttcctgaact ccgacgttgg tctgggcttc      420

gtgaaaggct tctccgaaat gttcgaaaaa ctgctcggtt ttgccaacga agggactaac      480

ttcgtctttg gtagcatgaa tgatcaaggc ctggcattct tcttcctgaa agtgctgtgc      540

ccaatcgtct ttatctctgc gctgatcggt attctccagc atattcgcgt attgccggtg      600

attatccgcg caattggttt cctgctctcc aaagtcaacg gcatgggcaa actggaatcc      660

tttaacgccg tcagctccct gattctgggt cagtctgaaa actttattgc ctataaagat      720

atcctcggca aaatctcccg caatcgtatg tacaccatgg cagcaacggc gatgtccacc      780

gtgtcgatgt ccatcgttgg tgcatatatg accatgctgg agccgaaata cgtcgttgcg      840

gcgctggtac tgaacatgtt cagcaccttt atcgtgctgt cgctgatcaa cccttaccgt      900

gttgatgcca gtgaagaaaa cattcagatg tccaacctgc acgaaggtca gagcttcttc      960

gaaatgctgg gtgaatacat tctggcaggt ttcaaagttg ccattatcgt tgccgcgatg     1020

ctgatcggct ttatcgccct gatcgctgca ctgaacgctc tgtttgctac cgtgactggc     1080

tggtttggct acagcatctc cttccagggc atcctgggtt acatcttcta tccgattgca     1140

tgggtgatgg gtgttccttc cagtgaagca ctgcaagtgg gcagtatcat ggcgaccaaa     1200

ctggtttcca acgagttcgt tgcgatgatg gatctgcaga aaattgcttc cacgctctct     1260

ccgcgtgcgg aaggcatcat ctctgtgttc ctggtttcct tcgctaactt ctcttcaatc     1320

gggattatcg cgggtgcggt taaaggcctg aatgaagagc aaggtaacgt ggtttctcgc     1380

ttcggtctga aactggttta cggctctacc ctggtgagtg tgctgtctgc gtcaatcgca     1440

gcactggtgc tgtaa                                                      1455


<210> 858
<211> 3837
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="PfnrS-xdhABC"

<400> 858
ggtaccagtt gttcttattg gtggtgttgc tttatggttg catcgtagta aatggttgta       60

acaaaagcaa tttttccggc tgtctgtata caaaaacgcc gtaaagtttg agcgaagtca      120

ataaactctc tacccattca gggcaatatc tctcttggat ccaaagtgaa ctctagaaat      180

aattttgttt aactttaaga aggagatata catatgcgcg tcgatgccat tgctaaggtc      240

accgggcggg cacgatatac tgacgattat attatggcgg gcatgtgtta cgcgaaatat      300

gtacgtagcc ctatcgcaca tggttatgct gtaaatatta atgatgaaca agccaggagt      360

ttgccgggcg tcctggcgat ttttacctgg gaagatgtgc cagaaatccc attcgccacg      420

gcagggcatg cctggacact tgacgaaaac aagcgcgata ccgccgatcg tgccctgcta      480

acgcgtcatg ttcgtcatca tggtgacgcc gttgccatcg tcgtggcccg cgatgaactc      540

acggcagaaa aagcggcgca attggtcagc attgagtggc aagaattacc cgttatcacc      600

tcgccagaag cggcgctggc agaagacgct gcaccaatcc ataacggtgg caatttactg      660

aaacaaagca cgatgtcgac gggtaatgtc caacaaacaa tcgatgccgc cgactaccag      720

gtacaggggc actatcagac tcccgttatt caacattgtc atatggaaag cgtgacatcg      780

ctggcatgga tggaggatga ctcgcgaatt accatcgttt ccagcaccca gatcccgcac      840

attgttcgcc gcgtggttgg tcaggcgctg gatattccct ggtcatgcgt acgagtcatc      900

aaaccgttta tcggtggcgg ttttggtaat aaacaggatg tactggaaga gccaatggcg      960

gcattcctga ccagcaaact tggcggcatt ccggtgaaag tttcccttag ccgtgaagag     1020

tgtttcctcg caacccgtac ccgccacgct tttactattg acgggcaaat gggcgtgaac     1080

cgcgacggaa cattgaaagg ttatagtctg gatgttctgt ctaacaccgg cgcttatgca     1140

tctcacgggc actccattgc ttctgctggg gggaataaag tcgcttacct ttatcctcgt     1200

tgtgcctacg cttacagttc aaagacctgc tataccaacc tcccctcggc tggtgcgatg     1260

cgtggttatg gcgcgccaca agtcgtattt gccgttgagt ctatgcttga tgatgccgcg     1320

acagcgttag gtattgatcc tgttgaaatt cgtttacgca acgccgcccg cgaaggagat     1380

gctaatccgc tcacgggaaa acgtatttac agcgcagggt tgccggagtg tcttgaaaaa     1440

ggccggaaaa tctttgaatg ggaaaaacgc cgtgcagagt gccagaacca gcaaggcaat     1500

ttacgtcgtg gcgttggcgt cgcctgtttt agctacacct ctaacacctg gcctgtcggc     1560

gtagaaatag caggcgcgcg cctgttgatg aatcaggatg gaaccatcaa cgtgcaaagc     1620

ggcgcgacgg aaatcggcca gggtgccgac accgtgttct cgcaaatggt ggcagaaacc     1680

gtgggagttc cggtcagcga tgttcacgtt atttcaaccc aagataccga cgttacacca     1740

ttcgaccccg gcgcatttgc ctcacgtcag agctatgttg ccgcgcctgc gctgcgcagt     1800

gcagcactgt tattaaaaga gaaaatcatc gctcacgccg cagtcatgct acatcagtca     1860

gcgatgaatc tgaccctgat aaaaggccat atcgtgctga ttgaaagacc ggaagaaccg     1920

ttaatgtcgt taaaagattt ggcgatggac gctttctacc accctgaacg cggcgggcag     1980

ctctctgccg aaagctccat caaaaccacc actaacccac cggcgtttgg ctgtaccttt     2040

gttgatctga cggtcgatat tgcactgtgc aaagtcacca tcaaccgcat cctcaacgtt     2100

catgattcgg gccatattct taatccgctg ctggcagaag gtcaggtaca cggcggaatg     2160

ggaatgggca ttggctgggc gctatttgaa gagatgatca tcgatgcgaa aagcggcgtg     2220

gtccgtaacc ccaatctgct ggattacaaa atgccgacca tgccggatct gccacaactg     2280

gaaagcgcgt tcgtcgaaat caatgagccg caatcagcat acggacataa gtcactgggt     2340

gagcccccca taattcctgt agccgctgct attcgtaacg cggtgaagat ggctaccggt     2400

gttgcaatca atacactgcc gctaacgcca aaacgattat atgaagaatt ccatctggca     2460

ggattgattt gaggataaca tcatgtttga ttttgcttct taccatcgcg caaccaccct     2520

tgccgatgcc atcaccctgc tggctgacaa tccgcaggcc aaattgcttg ccggtggcac     2580

tgacgtactg atacagcttc accatcacaa tgaccgctat cgccatattg ttgatatcca     2640

caatctggca gagcttcagg gaataacaca ggcggaagat ggcgcgctgc gaatcggctc     2700

tgcgacaaca tttactcagc tcattgaaga tcccgtaatc caacgcaatc tcccggcgtt     2760

atgtgctgcg gctgcatcaa tcgccgggcc gcagatccgt aatgtcgcca cctacggcgg     2820

aaatatttgc aacggtgcca ccagcgcaga ttctgccacg ccaacgctaa tttatgacgc     2880

gaaactggag ctccactccc cacgcggtgt tcgtttcgtc ccgattaatg gctttcacac     2940

cgggccgggc aaagtgtctc ttgagcatga cgaaatcctt gtcgcctttc attttccgcc     3000

acagccgaaa gaacacgcgg gcagcgcgca ttttaaatat gccatgcgcg acgcaatgga     3060

tatttcaaca attggctgcg ccgcacattg ccgactggat aacggcaatt tcagcgaatt     3120

acgcctggca tttggtgttg ccgcgccaac gccgattcgc tgccaacatg ccgaacagac     3180

tgcacaaaat gcgccattaa acctgcaaac gctggaagcc atcagcgaat cagtcctgca     3240

agatgtcgcc ccgcgttctt catggcgggc cagtaaagag tttcgtctgc atctcatcca     3300

gacgatgacc aaaaaagtga ttagcgaagc cgtcgccgcg gcggggggaa aattgcaatg     3360

aatcacagcg aaacaattac catcgaatgc accattaacg ggatgccttt tcagcttcac     3420

gccgcgccag gaatgccgct ttcggaacta ctccgagaac aagggcttct tagtgtcaaa     3480

caaggttgct gcgtaggcga atgcggtgcc tgtacggtgc tggtcgacgg cactgcgata     3540

gacagttgct tattccttgc gacctgggct gaaggaaaag agatccgcac gctggaaggt     3600

gaagcgaaag gcggtaaact ttctcatgtc caactggctt atgcgaaatc tggtgcagtg     3660

caatgcgggt tttgtacgcc gggcctgatt atggctacca cggcgatgct ggcaaaacca     3720

cgcgaaaaac cattaaccat tacggaaatt cgtcgtggac tggcgggaaa tctttgtcgc     3780

tgcacggggt atcagatgat tgtaaataca gttctggatt gcgagaaaac gaagtaa        3837


<210> 859
<211> 3624
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="xdhABC"

<400> 859
atgcgcgtcg atgccattgc taaggtcacc gggcgggcac gatatactga cgattatatt       60

atggcgggca tgtgttacgc gaaatatgta cgtagcccta tcgcacatgg ttatgctgta      120

aatattaatg atgaacaagc caggagtttg ccgggcgtcc tggcgatttt tacctgggaa      180

gatgtgccag aaatcccatt cgccacggca gggcatgcct ggacacttga cgaaaacaag      240

cgcgataccg ccgatcgtgc cctgctaacg cgtcatgttc gtcatcatgg tgacgccgtt      300

gccatcgtcg tggcccgcga tgaactcacg gcagaaaaag cggcgcaatt ggtcagcatt      360

gagtggcaag aattacccgt tatcacctcg ccagaagcgg cgctggcaga agacgctgca      420

ccaatccata acggtggcaa tttactgaaa caaagcacga tgtcgacggg taatgtccaa      480

caaacaatcg atgccgccga ctaccaggta caggggcact atcagactcc cgttattcaa      540

cattgtcata tggaaagcgt gacatcgctg gcatggatgg aggatgactc gcgaattacc      600

atcgtttcca gcacccagat cccgcacatt gttcgccgcg tggttggtca ggcgctggat      660

attccctggt catgcgtacg agtcatcaaa ccgtttatcg gtggcggttt tggtaataaa      720

caggatgtac tggaagagcc aatggcggca ttcctgacca gcaaacttgg cggcattccg      780

gtgaaagttt cccttagccg tgaagagtgt ttcctcgcaa cccgtacccg ccacgctttt      840

actattgacg ggcaaatggg cgtgaaccgc gacggaacat tgaaaggtta tagtctggat      900

gttctgtcta acaccggcgc ttatgcatct cacgggcact ccattgcttc tgctgggggg      960

aataaagtcg cttaccttta tcctcgttgt gcctacgctt acagttcaaa gacctgctat     1020

accaacctcc cctcggctgg tgcgatgcgt ggttatggcg cgccacaagt cgtatttgcc     1080

gttgagtcta tgcttgatga tgccgcgaca gcgttaggta ttgatcctgt tgaaattcgt     1140

ttacgcaacg ccgcccgcga aggagatgct aatccgctca cgggaaaacg tatttacagc     1200

gcagggttgc cggagtgtct tgaaaaaggc cggaaaatct ttgaatggga aaaacgccgt     1260

gcagagtgcc agaaccagca aggcaattta cgtcgtggcg ttggcgtcgc ctgttttagc     1320

tacacctcta acacctggcc tgtcggcgta gaaatagcag gcgcgcgcct gttgatgaat     1380

caggatggaa ccatcaacgt gcaaagcggc gcgacggaaa tcggccaggg tgccgacacc     1440

gtgttctcgc aaatggtggc agaaaccgtg ggagttccgg tcagcgatgt tcacgttatt     1500

tcaacccaag ataccgacgt tacaccattc gaccccggcg catttgcctc acgtcagagc     1560

tatgttgccg cgcctgcgct gcgcagtgca gcactgttat taaaagagaa aatcatcgct     1620

cacgccgcag tcatgctaca tcagtcagcg atgaatctga ccctgataaa aggccatatc     1680

gtgctgattg aaagaccgga agaaccgtta atgtcgttaa aagatttggc gatggacgct     1740

ttctaccacc ctgaacgcgg cgggcagctc tctgccgaaa gctccatcaa aaccaccact     1800

aacccaccgg cgtttggctg tacctttgtt gatctgacgg tcgatattgc actgtgcaaa     1860

gtcaccatca accgcatcct caacgttcat gattcgggcc atattcttaa tccgctgctg     1920

gcagaaggtc aggtacacgg cggaatggga atgggcattg gctgggcgct atttgaagag     1980

atgatcatcg atgcgaaaag cggcgtggtc cgtaacccca atctgctgga ttacaaaatg     2040

ccgaccatgc cggatctgcc acaactggaa agcgcgttcg tcgaaatcaa tgagccgcaa     2100

tcagcatacg gacataagtc actgggtgag ccccccataa ttcctgtagc cgctgctatt     2160

cgtaacgcgg tgaagatggc taccggtgtt gcaatcaata cactgccgct aacgccaaaa     2220

cgattatatg aagaattcca tctggcagga ttgatttgag gataacatca tgtttgattt     2280

tgcttcttac catcgcgcaa ccacccttgc cgatgccatc accctgctgg ctgacaatcc     2340

gcaggccaaa ttgcttgccg gtggcactga cgtactgata cagcttcacc atcacaatga     2400

ccgctatcgc catattgttg atatccacaa tctggcagag cttcagggaa taacacaggc     2460

ggaagatggc gcgctgcgaa tcggctctgc gacaacattt actcagctca ttgaagatcc     2520

cgtaatccaa cgcaatctcc cggcgttatg tgctgcggct gcatcaatcg ccgggccgca     2580

gatccgtaat gtcgccacct acggcggaaa tatttgcaac ggtgccacca gcgcagattc     2640

tgccacgcca acgctaattt atgacgcgaa actggagctc cactccccac gcggtgttcg     2700

tttcgtcccg attaatggct ttcacaccgg gccgggcaaa gtgtctcttg agcatgacga     2760

aatccttgtc gcctttcatt ttccgccaca gccgaaagaa cacgcgggca gcgcgcattt     2820

taaatatgcc atgcgcgacg caatggatat ttcaacaatt ggctgcgccg cacattgccg     2880

actggataac ggcaatttca gcgaattacg cctggcattt ggtgttgccg cgccaacgcc     2940

gattcgctgc caacatgccg aacagactgc acaaaatgcg ccattaaacc tgcaaacgct     3000

ggaagccatc agcgaatcag tcctgcaaga tgtcgccccg cgttcttcat ggcgggccag     3060

taaagagttt cgtctgcatc tcatccagac gatgaccaaa aaagtgatta gcgaagccgt     3120

cgccgcggcg gggggaaaat tgcaatgaat cacagcgaaa caattaccat cgaatgcacc     3180

attaacggga tgccttttca gcttcacgcc gcgccaggaa tgccgctttc ggaactactc     3240

cgagaacaag ggcttcttag tgtcaaacaa ggttgctgcg taggcgaatg cggtgcctgt     3300

acggtgctgg tcgacggcac tgcgatagac agttgcttat tccttgcgac ctgggctgaa     3360

ggaaaagaga tccgcacgct ggaaggtgaa gcgaaaggcg gtaaactttc tcatgtccaa     3420

ctggcttatg cgaaatctgg tgcagtgcaa tgcgggtttt gtacgccggg cctgattatg     3480

gctaccacgg cgatgctggc aaaaccacgc gaaaaaccat taaccattac ggaaattcgt     3540

cgtggactgg cgggaaatct ttgtcgctgc acggggtatc agatgattgt aaatacagtt     3600

ctggattgcg agaaaacgaa gtaa                                            3624


<210> 860
<211> 2803
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="PfnrS-add-xapA-deoD"

<400> 860
ggtaccagtt gttcttattg gtggtgttgc tttatggttg catcgtagta aatggttgta       60

acaaaagcaa tttttccggc tgtctgtata caaaaacgcc gtaaagtttg agcgaagtca      120

ataaactctc tacccattca gggcaatatc tctcttggat ccaaagtgaa ctctagaaat      180

aattttgttt aactttaaga aggagatata catatgattg ataccaccct gccattaact      240

gatatccatc gccaccttga tggcaacatt cgtccccaga ccattcttga acttggccgc      300

cagtataata tctcgcttcc tgcacaatcc ctggaaacac tgattcccca cgttcaggtc      360

attgccaacg aacccgatct ggtgagcttt ctgactaaac ttgactgggg cgttaaagtt      420

ctcgcctctc ttgatgcctg ccgccgcgtg gcatttgaaa acattgaaga tgcagcccgt      480

aacggcctgc actatgtcga gctgcgtttt tcaccaggct acatggcaat ggcacatcag      540

ctgcctgtag cgggtgttgt cgaagcggtg atcgatggcg tacgtgaagg ttgccgcacc      600

tttggtgtgc aggcgaagct tatcggtatt atgagccgga ccttcggcga agccgcctgt      660

cagcaagagc tggaggcctt tttagcccac cgtgaccaga ttaccgcact tgatttagcc      720

ggtgatgaac ttggtttccc gggaagtctg ttcctttctc atttcaaccg cgcgcgtgat      780

gcgggctggc atattaccgt ccatgcaggc gaagctgccg gaccggaaag catctggcag      840

gcgattcgtg aactgggggc ggagcgtatt ggacatggcg taaaagccat tgaagatcgg      900

gcgctgatgg attttctcgc cgagcaacaa attggtattg aatcctgtct gacctccaat      960

attcagacca gcaccgtggc ggatctggct gcacatccgc tgaaaacgtt ccttgagcat     1020

ggcattcgtg ccagcattaa cactgacgat ccaggcgtgc agggagtgga tatcattcac     1080

gaatataccg ttgccgcgcc agctgctggg ttatcccgcg agcaaatccg ccaggcacag     1140

attaatggtc tggaaatggc tttcctcagc gcagaggaaa aacgcgcact gcgagaaaaa     1200

gtcgccgcga agtaaaagaa ggagatatac atatgtatca ggctcagttt tctcataacc     1260

cactgtattg cgtagatatt atcaagactt ataaacctga tttcacgcca cgagtggcct     1320

ttattttagg ttccgggctg ggcgcgctgg ccgatcagat tgagaacgcg gtcgcaattt     1380

cctacgaaaa gctgcctggg ttcccggtaa gtaccgtaca cggtcatgcg ggtgagctgg     1440

tgctgggtta tctccagggg gtgccagtgg cgtgtatgaa aggtcgcgga catttctacg     1500

aaggtcgtgg gatgaccatc atgacggatg caatccgtac ctttaagttg ctgggctgcg     1560

agttgctgtt ctgcaccaat gcggctggct cactgcgccc tgaagtgggg gccggcagtc     1620

tggtcgcatt gaaagatcac atcaacacca tgccgggaac gccgatggtg ggtcttaatg     1680

atgaacgttt tggtgagcgc ttcttctcgc tggcgaatgc ctacgatgcg gaataccgcg     1740

cactgttaca aaaagtggcg aaagaagagg ggttccctct gacggagggc gtgttcgtct     1800

catatccggg gccgaatttc gagactgcgg cggaaattcg catgatgcaa attattggtg     1860

gggatgttgt tggtatgtct gtggtgcctg aggttatttc agctcgccat tgcgaactta     1920

aagtcgttgc ggtctctgcg attaccaaca tggcggaagg tctgagtgac gtgaagcttt     1980

ctcatgccca aacgctggca gcagcggaac tctcaaagca aaactttatt aatcttattt     2040

gcggctttct gcgcaaaatt gcctgaaaga aggagatata catatggcta ccccacacat     2100

taatgcagaa atgggcgatt tcgctgacgt agttttgatg ccaggcgacc cgctgcgtgc     2160

gaagtatatt gctgaaactt tccttgaaga tgcccgtgaa gtgaacaacg ttcgcggtat     2220

gctgggcttc accggtactt acaaaggccg caaaatttcc gtaatgggtc acggtatggg     2280

tatcccgtcc tgctccatct acaccaaaga actgatcacc gatttcggcg tgaagaaaat     2340

tatccgcgtg ggttcctgtg gcgcagttct gccgcacgta aaactacgcg acgtcgttat     2400

cggtatgggt gcctgcaccg attccaaagt taaccgcatc cgttttaaag accatgactt     2460

tgccgctatc gctgactttg acatggtgcg taacgcggta gacgcggcta aagcactggg     2520

cgttgatgct cgcgtgggta acctgttctc cgctgacctg ttctactctc cggacggcga     2580

aatgttcgac gtgatggaaa aatacggcat cctcggcgtg gaaatggaag cggctggtat     2640

ctacggcgtc gctgcagaat ttggcgcgaa agccctgacc atctgcaccg tgtctgacca     2700

catccgcact cacgagcaga ccactgccgc tgagcgtcag accaccttca acgacatgat     2760

caaaatcgca ctggaatccg ttctgctggg cgataaagag taa                       2803


<210> 861
<211> 2633
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="add-xapA-deoD"

<400> 861
ctctagaaat aattttgttt aactttaaga aggagatata catatgattg ataccaccct       60

gccattaact gatatccatc gccaccttga tggcaacatt cgtccccaga ccattcttga      120

acttggccgc cagtataata tctcgcttcc tgcacaatcc ctggaaacac tgattcccca      180

cgttcaggtc attgccaacg aacccgatct ggtgagcttt ctgactaaac ttgactgggg      240

cgttaaagtt ctcgcctctc ttgatgcctg ccgccgcgtg gcatttgaaa acattgaaga      300

tgcagcccgt aacggcctgc actatgtcga gctgcgtttt tcaccaggct acatggcaat      360

ggcacatcag ctgcctgtag cgggtgttgt cgaagcggtg atcgatggcg tacgtgaagg      420

ttgccgcacc tttggtgtgc aggcgaagct tatcggtatt atgagccgga ccttcggcga      480

agccgcctgt cagcaagagc tggaggcctt tttagcccac cgtgaccaga ttaccgcact      540

tgatttagcc ggtgatgaac ttggtttccc gggaagtctg ttcctttctc atttcaaccg      600

cgcgcgtgat gcgggctggc atattaccgt ccatgcaggc gaagctgccg gaccggaaag      660

catctggcag gcgattcgtg aactgggggc ggagcgtatt ggacatggcg taaaagccat      720

tgaagatcgg gcgctgatgg attttctcgc cgagcaacaa attggtattg aatcctgtct      780

gacctccaat attcagacca gcaccgtggc ggatctggct gcacatccgc tgaaaacgtt      840

ccttgagcat ggcattcgtg ccagcattaa cactgacgat ccaggcgtgc agggagtgga      900

tatcattcac gaatataccg ttgccgcgcc agctgctggg ttatcccgcg agcaaatccg      960

ccaggcacag attaatggtc tggaaatggc tttcctcagc gcagaggaaa aacgcgcact     1020

gcgagaaaaa gtcgccgcga agtaaaagaa ggagatatac atatgtatca ggctcagttt     1080

tctcataacc cactgtattg cgtagatatt atcaagactt ataaacctga tttcacgcca     1140

cgagtggcct ttattttagg ttccgggctg ggcgcgctgg ccgatcagat tgagaacgcg     1200

gtcgcaattt cctacgaaaa gctgcctggg ttcccggtaa gtaccgtaca cggtcatgcg     1260

ggtgagctgg tgctgggtta tctccagggg gtgccagtgg cgtgtatgaa aggtcgcgga     1320

catttctacg aaggtcgtgg gatgaccatc atgacggatg caatccgtac ctttaagttg     1380

ctgggctgcg agttgctgtt ctgcaccaat gcggctggct cactgcgccc tgaagtgggg     1440

gccggcagtc tggtcgcatt gaaagatcac atcaacacca tgccgggaac gccgatggtg     1500

ggtcttaatg atgaacgttt tggtgagcgc ttcttctcgc tggcgaatgc ctacgatgcg     1560

gaataccgcg cactgttaca aaaagtggcg aaagaagagg ggttccctct gacggagggc     1620

gtgttcgtct catatccggg gccgaatttc gagactgcgg cggaaattcg catgatgcaa     1680

attattggtg gggatgttgt tggtatgtct gtggtgcctg aggttatttc agctcgccat     1740

tgcgaactta aagtcgttgc ggtctctgcg attaccaaca tggcggaagg tctgagtgac     1800

gtgaagcttt ctcatgccca aacgctggca gcagcggaac tctcaaagca aaactttatt     1860

aatcttattt gcggctttct gcgcaaaatt gcctgaaaga aggagatata catatggcta     1920

ccccacacat taatgcagaa atgggcgatt tcgctgacgt agttttgatg ccaggcgacc     1980

cgctgcgtgc gaagtatatt gctgaaactt tccttgaaga tgcccgtgaa gtgaacaacg     2040

ttcgcggtat gctgggcttc accggtactt acaaaggccg caaaatttcc gtaatgggtc     2100

acggtatggg tatcccgtcc tgctccatct acaccaaaga actgatcacc gatttcggcg     2160

tgaagaaaat tatccgcgtg ggttcctgtg gcgcagttct gccgcacgta aaactacgcg     2220

acgtcgttat cggtatgggt gcctgcaccg attccaaagt taaccgcatc cgttttaaag     2280

accatgactt tgccgctatc gctgactttg acatggtgcg taacgcggta gacgcggcta     2340

aagcactggg cgttgatgct cgcgtgggta acctgttctc cgctgacctg ttctactctc     2400

cggacggcga aatgttcgac gtgatggaaa aatacggcat cctcggcgtg gaaatggaag     2460

cggctggtat ctacggcgtc gctgcagaat ttggcgcgaa agccctgacc atctgcaccg     2520

tgtctgacca catccgcact cacgagcaga ccactgccgc tgagcgtcag accaccttca     2580

acgacatgat caaaatcgca ctggaatccg ttctgctggg cgataaagag taa            2633


<210> 862
<211> 1053
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="fbrAroG"

<400> 862
atgaattatc agaacgacga tttacgcatc aaagaaatca aagagttact tcctcctgtc       60

gcattgctgg aaaaattccc cgctactgaa aatgccgcga atacggtcgc ccatgcccga      120

aaagcgatcc ataagatcct gaaaggtaat gatgatcgcc tgttggtggt gattggccca      180

tgctcaattc atgatcctgt cgcggctaaa gagtatgcca ctcgcttgct gacgctgcgt      240

gaagagctgc aagatgagct ggaaatcgtg atgcgcgtct attttgaaaa gccgcgtact      300

acggtgggct ggaaagggct gattaacgat ccgcatatgg ataacagctt ccagatcaac      360

gacggtctgc gtattgcccg caaattgctg ctcgatatta acgacagcgg tctgccagcg      420

gcgggtgaat tcctggatat gatcacccta caatatctcg ctgacctgat gagctggggc      480

gcaattggcg cacgtaccac cgaatcgcag gtgcaccgcg aactggcgtc tggtctttct      540

tgtccggtag gtttcaaaaa tggcactgat ggtacgatta aagtggctat cgatgccatt      600

aatgccgccg gtgcgccgca ctgcttcctg tccgtaacga aatgggggca ttcggcgatt      660

gtgaatacca gcggtaacgg cgattgccat atcattctgc gcggcggtaa agagcctaac      720

tacagcgcga agcacgttgc tgaagtgaaa gaagggctga acaaagcagg cctgccagcg      780

caggtgatga tcgatttcag ccatgctaac tcgtcaaaac aattcaaaaa gcagatggat      840

gtttgtactg acgtttgcca gcagattgcc ggtggcgaaa aggccattat tggcgtgatg      900

gtggaaagcc atctggtgga aggcaatcag agcctcgaga gcggggaacc gctggcctac      960

ggtaagagca tcaccgatgc ctgcattggc tgggatgata ccgatgctct gttacgtcaa     1020

ctggcgagtg cagtaaaagc gcgtcgcggg taa                                  1053


<210> 863
<211> 2351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="fbrAroG-serA"

<400> 863
ctctagaaat aattttgttt aactttaaga aggagatata catatgaatt atcagaacga       60

cgatttacgc atcaaagaaa tcaaagagtt acttcctcct gtcgcattgc tggaaaaatt      120

ccccgctact gaaaatgccg cgaatacggt cgcccatgcc cgaaaagcga tccataagat      180

cctgaaaggt aatgatgatc gcctgttggt ggtgattggc ccatgctcaa ttcatgatcc      240

tgtcgcggct aaagagtatg ccactcgctt gctgacgctg cgtgaagagc tgcaagatga      300

gctggaaatc gtgatgcgcg tctattttga aaagccgcgt actacggtgg gctggaaagg      360

gctgattaac gatccgcata tggataacag cttccagatc aacgacggtc tgcgtattgc      420

ccgcaaattg ctgctcgata ttaacgacag cggtctgcca gcggcgggtg aattcctgga      480

tatgatcacc ctacaatatc tcgctgacct gatgagctgg ggcgcaattg gcgcacgtac      540

caccgaatcg caggtgcacc gcgaactggc gtctggtctt tcttgtccgg taggtttcaa      600

aaatggcact gatggtacga ttaaagtggc tatcgatgcc attaatgccg ccggtgcgcc      660

gcactgcttc ctgtccgtaa cgaaatgggg gcattcggcg attgtgaata ccagcggtaa      720

cggcgattgc catatcattc tgcgcggcgg taaagagcct aactacagcg cgaagcacgt      780

tgctgaagtg aaagaagggc tgaacaaagc aggcctgcca gcgcaggtga tgatcgattt      840

cagccatgct aactcgtcaa aacaattcaa aaagcagatg gatgtttgta ctgacgtttg      900

ccagcagatt gccggtggcg aaaaggccat tattggcgtg atggtggaaa gccatctggt      960

ggaaggcaat cagagcctcg agagcgggga accgctggcc tacggtaaga gcatcaccga     1020

tgcctgcatt ggctgggatg ataccgatgc tctgttacgt caactggcga gtgcagtaaa     1080

agcgcgtcgc gggtaatact taagaaggag atatacatat ggcaaaggta tcgctggaga     1140

aagacaagat taagtttctg ctggtagaag gcgtgcacca aaaggcgctg gaaagccttc     1200

gtgcagctgg ttacaccaac atcgaatttc acaaaggcgc gctggatgat gaacaattaa     1260

aagaatccat ccgcgatgcc cacttcatcg gcctgcgatc ccgtacccat ctgactgaag     1320

acgtgatcaa cgccgcagaa aaactggtcg ctattggctg tttctgtatc ggaacaaatc     1380

aggttgatct ggatgcggcg gcaaagcgcg ggatcccggt atttaacgca ccgttctcaa     1440

atacgcgctc tgttgcggag ctggtgattg gcgaactgct gctgctattg cgcggcgtgc     1500

cagaagccaa tgctaaagcg catcgtggcg tgtggaacaa actggcggcg ggttcttttg     1560

aagcgcgcgg caaaaagctg ggtatcatcg gctacggtca tattggtacg caattgggca     1620

ttctggctga atcgctggga atgtatgttt acttttatga tattgaaaac aaactgccgc     1680

tgggcaacgc cactcaggta cagcatcttt ctgacctgct gaatatgagc gatgtggtga     1740

gtctgcatgt accagagaat ccgtccacca aaaatatgat gggcgcgaaa gagatttcgc     1800

taatgaagcc cggctcgctg ctgattaatg cttcgcgcgg tactgtggtg gatattccag     1860

cgctgtgtga cgcgctggcg agcaaacatc tggcgggggc ggcaatcgac gtattcccga     1920

cggaaccggc gaccaatagc gatccattta cctctccgct gtgtgaattc gacaatgtcc     1980

ttctgacgcc acacattggc ggttcgactc aggaagcgca ggagaatatc ggcttggaag     2040

ttgcgggtaa attgatcaag tattctgaca atggctcaac gctctctgcg gtgaacttcc     2100

cggaagtctc gctgccactg cacggtgggc gtcgtctgat gcacatccac gaaaaccgtc     2160

cgggcgtgct aactgcgctc aacaaaattt ttgccgagca gggcgtcaac atcgccgcgc     2220

aatatctaca aacttccgcc cagatgggtt atgtagttat tgatattgaa gccgacgaag     2280

acgttgccga aaaagcgctg caggcaatga aagctattcc gggtaccatt cgcgcccgtc     2340

tgctgtacta a                                                          2351


<210> 864
<211> 1233
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="SerA"

<400> 864
atggcaaagg tatcgctgga gaaagacaag attaagtttc tgctggtaga aggcgtgcac       60

caaaaggcgc tggaaagcct tcgtgcagct ggttacacca acatcgaatt tcacaaaggc      120

gcgctggatg atgaacaatt aaaagaatcc atccgcgatg cccacttcat cggcctgcga      180

tcccgtaccc atctgactga agacgtgatc aacgccgcag aaaaactggt cgctattggc      240

tgtttctgta tcggaacaaa tcaggttgat ctggatgcgg cggcaaagcg cgggatcccg      300

gtatttaacg caccgttctc aaatacgcgc tctgttgcgg agctggtgat tggcgaactg      360

ctgctgctat tgcgcggcgt gccagaagcc aatgctaaag cgcatcgtgg cgtgtggaac      420

aaactggcgg cgggttcttt tgaagcgcgc ggcaaaaagc tgggtatcat cggctacggt      480

catattggta cgcaattggg cattctggct gaatcgctgg gaatgtatgt ttacttttat      540

gatattgaaa acaaactgcc gctgggcaac gccactcagg tacagcatct ttctgacctg      600

ctgaatatga gcgatgtggt gagtctgcat gtaccagaga atccgtccac caaaaatatg      660

atgggcgcga aagagatttc gctaatgaag cccggctcgc tgctgattaa tgcttcgcgc      720

ggtactgtgg tggatattcc agcgctgtgt gacgcgctgg cgagcaaaca tctggcgggg      780

gcggcaatcg acgtattccc gacggaaccg gcgaccaata gcgatccatt tacctctccg      840

ctgtgtgaat tcgacaatgt ccttctgacg ccacacattg gcggttcgac tcaggaagcg      900

caggagaata tcggcttgga agttgcgggt aaattgatca agtattctga caatggctca      960

acgctctctg cggtgaactt cccggaagtc tcgctgccac tgcacggtgg gcgtcgtctg     1020

atgcacatcc acgaaaaccg tccgggcgtg ctaactgcgc tcaacaaaat ttttgccgag     1080

cagggcgtca acatcgccgc gcaatatcta caaacttccg cccagatggg ttatgtagtt     1140

attgatattg aagccgacga agacgttgcc gaaaaagcgc tgcaggcaat gaaagctatt     1200

ccgggtacca ttcgcgcccg tctgctgtac taa                                  1233


<210> 865
<211> 1424
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ptet-kynU(Pseudomonas)"

<400> 865
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattat ataaaagtgg gaggtgcccg      120

aatgacgacc cgaaatgatt gcctagcgtt ggatgcacag gacagtctgg ctccgctgcg      180

ccaacaattt gcgctgccgg agggtgtgat atacctggat ggcaattcgc tgggcgcacg      240

tccggtagct gcgctggctc gcgcgcaggc tgtgatcgca gaagaatggg gcaacgggtt      300

gatccgttca tggaactctg cgggctggcg tgatctgtct gaacgcctgg gtaatcgcct      360

ggctaccctg attggtgcgc gcgatgggga agtagttgtt actgatacca cctcgattaa      420

tctgtttaaa gtgctgtcag cggcgctgcg cgtgcaagct acccgtagcc cggagcgccg      480

tgttatcgtg actgagacct cgaatttccc gaccgacctg tatattgcgg aagggttggc      540

ggatatgctg caacaaggtt acactctgcg tttggtggat tcaccggaag agctgccaca      600

ggctatagat caggacaccg cggtggtgat gctgacgcac gtaaattata aaaccggtta      660

tatgcacgac atgcaggctc tgaccgcgtt gagccacgag tgtggggctc tggcgatttg      720

ggatctggcg cactctgctg gcgctgtgcc ggtggacctg caccaagcgg gcgcggacta      780

tgcgattggc tgcacgtaca aatacctgaa tggcggcccg ggttcgcaag cgtttgtttg      840

ggtttcgccg caactgtgcg acctggtacc gcagccgctg tctggttggt tcggccatag      900

tcgccaattc gcgatggagc cgcgctacga accttctaac ggcattgctc gctatctgtg      960

cggcactcag cctattacta gcttggctat ggtggagtgc ggcctggatg tgtttgcgca     1020

gacggatatg gcttcgctgc gccgtaaaag tctggcgctg actgatctgt tcatcgagct     1080

ggttgaacaa cgctgcgctg cacacgaact gaccctggtt actccacgtg aacacgcgaa     1140

acgcggctct cacgtgtctt ttgaacaccc cgagggttac gctgttattc aagctctgat     1200

tgatcgtggc gtgatcggcg attaccgtga gccacgtatt atgcgtttcg gtttcactcc     1260

tctgtatact acttttacgg aagtttggga tgcagtacaa atcctgggcg aaatcctgga     1320

tcgtaagact tgggcgcagg ctcagtttca ggtgcgccac tctgttactt aaaaataaaa     1380

cgaaaggctc agtcgaaaga ctgggccttt cgttttatct gttg                      1424


<210> 866
<211> 1571
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ptet-kynU(Human)"

<400> 866
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaatatc aagacacgag gaggtaagat      120

tatggagcct tcatctttag aactgccagc ggacacggtg cagcgcatcg cggcggaact      180

gaagtgccat ccgactgatg agcgtgtggc gctgcatctg gacgaagaag ataaactgcg      240

ccactttcgt gaatgttttt atattcctaa aattcaagac ttgccgccgg tagatttgag      300

tctcgttaac aaagatgaaa acgcgatcta ctttctgggc aactctctgg gtctgcaacc      360

aaaaatggtt aaaacgtacc tggaggaaga actggataaa tgggcaaaaa tcgcggctta      420

tggtcacgaa gtgggcaagc gtccttggat tactggcgac gagtctattg tgggtttgat      480

gaaagatatt gtgggcgcga atgaaaagga aattgcactg atgaatgctc tgaccgttaa      540

tctgcacctg ctgatgctgt ctttttttaa accgaccccg aaacgctaca aaatactgct      600

ggaagcgaaa gcgtttccgt cggatcacta tgctatagaa agtcaactgc agttgcatgg      660

tctgaatatc gaggaatcta tgcgcatgat taaaccgcgt gagggtgaag aaacgctgcg      720

tattgaagac attctggaag ttattgaaaa agaaggtgat tctatcgcag ttatactgtt      780

ttctggcgtg cacttttata caggtcagca cttcaatatc ccggcaatca ctaaagcggg      840

gcaggcaaaa ggctgctatg ttggttttga cctggcgcat gcagtgggga atgttgaact      900

gtatctgcac gattggggcg ttgatttcgc gtgttggtgt agctacaaat atctgaacgc      960

tggcgcgggt ggcattgctg gcgcttttat tcacgaaaaa cacgcgcaca ccattaaacc     1020

ggctctggtt ggctggttcg gtcatgagct gagtactcgc tttaaaatgg ataacaaact     1080

gcaattgatt ccgggtgttt gcggcttccg tatcagcaat ccgccgattc tgctggtttg     1140

cagcctgcac gctagtctgg aaatctttaa gcaggcgact atgaaagcgc tgcgcaaaaa     1200

atctgtgctg ctgaccggct atctggagta tctgatcaaa cacaattatg gcaaagataa     1260

agctgcaact aaaaaaccgg tagtgaacat tatcaccccc tcacacgtgg aggagcgcgg     1320

ttgtcagctg actattactt tcagtgtacc taataaagat gtgttccagg aactggaaaa     1380

acgcggcgtt gtttgtgata aacgtaaccc gaatggtatt cgcgtggctc ctgtgccgct     1440

gtacaattca ttccacgatg tttataaatt caccaacctg ctgacttcta ttctcgacag     1500

tgctgagact aaaaattaaa aataaaacga aaggctcagt cgaaagactg ggcctttcgt     1560

tttatctgtt g                                                          1571


<210> 867
<211> 1310
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="ptet-kynU(Shewanella)"

<400> 867
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaatggt tcaccaccac aaggagggat      120

tatgctgctg aatgtaaaac aggacttttg cctggcaggc ccgggctacc tgctgaatca      180

ctcggttggc cgtccgctga aatcaactga gcaagcgctg aaacaagcat tttttgctcc      240

gtggcaagag agcggtcgtg aaccgtgggg ccagtggctg ggtgttattg ataatttcac      300

tgctgcgctg gcatctctgt ttaatggtca accgcaggat ttttgtccgc aggttaacct      360

gagcagcgcg ctgactaaaa ttgtgatgtc actggatcgt ctgactcgcg atctgacccg      420

caatggcggt gctgttgtgc tgatgtctga aatcgatttc ccatctatgg gcttcgcgtt      480

gaaaaaagcg ctgccagcga gctgcgaact gcgttttatc ccgaaaagtc tggacgtgac      540

tgatccgaac gtatgggatg cacacatctg tgatgatgta gacctggttt ttgtgtctca      600

cgcctatagt aatacgggcc aacaggctcc gctggcgcaa atcatctctc tggcgcgtga      660

acgtggctgc ctgtcactgg tggatgtagc gcaatcagcg gggattttgc cgctggatct      720

ggcgaaactg caaccggact tcatgatcgg cagttcggtt aaatggctgt gctcgggccc      780

tggtgcggca tatctgtggg ttaatccggc gattctgccg gaatgtcagc cgcaggatgt      840

gggctggttt tcacatgaga atccctttga attcgacatc cacgatttcc gctaccaccc      900

gactgcactg cgcttttggg gtggtacgcc gtcgatcgcg ccttatgcga tcgcggcgca      960

ctcgatcgaa tattttgcca atatcggctc gcaagtgatg cgtgaacaca acctgcaact     1020

gatggaaccg gtggttcagg cgctggacaa tgaactggtg agcccgcagg aagtggataa     1080

acgctcaggc actattattc tgcaattcgg tgaacgtcaa ccgcaaattc tggcggctct     1140

ggctgcggcg aacatttcgg tggacactcg ttctttgggg attcgtgtta gtccgcacat     1200

ttataatgat gaggcggaca ttgcgcgcct gctgggtgtg atcaaagcaa atcgctaaaa     1260

ataaaacgaa aggctcagtc gaaagactgg gcctttcgtt ttatctgttg                1310


<210> 868
<211> 1096
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="fbrAroG"

<400> 868
ctctagaaat aattttgttt aactttaaga aggagatata catatgaatt atcagaacga       60

cgatttacgc atcaaagaaa tcaaagagtt acttcctcct gtcgcattgc tggaaaaatt      120

ccccgctact gaaaatgccg cgaatacggt cgcccatgcc cgaaaagcga tccataagat      180

cctgaaaggt aatgatgatc gcctgttggt ggtgattggc ccatgctcaa ttcatgatcc      240

tgtcgcggct aaagagtatg ccactcgctt gctgacgctg cgtgaagagc tgcaagatga      300

gctggaaatc gtgatgcgcg tctattttga aaagccgcgt actacggtgg gctggaaagg      360

gctgattaac gatccgcata tggataacag cttccagatc aacgacggtc tgcgtattgc      420

ccgcaaattg ctgctcgata ttaacgacag cggtctgcca gcggcgggtg aattcctgga      480

tatgatcacc ctacaatatc tcgctgacct gatgagctgg ggcgcaattg gcgcacgtac      540

caccgaatcg caggtgcacc gcgaactggc gtctggtctt tcttgtccgg taggtttcaa      600

aaatggcact gatggtacga ttaaagtggc tatcgatgcc attaatgccg ccggtgcgcc      660

gcactgcttc ctgtccgtaa cgaaatgggg gcattcggcg attgtgaata ccagcggtaa      720

cggcgattgc catatcattc tgcgcggcgg taaagagcct aactacagcg cgaagcacgt      780

tgctgaagtg aaagaagggc tgaacaaagc aggcctgcca gcgcaggtga tgatcgattt      840

cagccatgct aactcgtcaa aacaattcaa aaagcagatg gatgtttgta ctgacgtttg      900

ccagcagatt gccggtggcg aaaaggccat tattggcgtg atggtggaaa gccatctggt      960

ggaaggcaat cagagcctcg agagcgggga accgctggcc tacggtaaga gcatcaccga     1020

tgcctgcatt ggctgggatg ataccgatgc tctgttacgt caactggcga gtgcagtaaa     1080

agcgcgtcgc gggtaa                                                     1096


<210> 869
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61133"

<400> 869
tctagagaaa gacccgagac actagatg                                          28


<210> 870
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61134"

<400> 870
tctagagaaa gaccggaaat actagatg                                          28


<210> 871
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61135"

<400> 871
tctagagaaa gaccggagac actagatg                                          28


<210> 872
<211> 6573
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="TrpEDCBA"

<400> 872
ctctagaaat aattttgttt aactttaaga aggagatata catatgcaaa cacaaaaacc       60

gactctcgaa ctgctaacct gcgaaggcgc ttatcgcgac aacccgactg cgctttttca      120

ccagttgtgt ggggatcgtc cggcaacgct gctgctggaa tccgcagata tcgacagcaa      180

agatgattta aaaagcctgc tgctggtaga cagtgcgctg cgcattacag cattaagtga      240

cactgtcaca atccaggcgc tttccggcaa tggagaagcc ctgttgacac tactggataa      300

cgccttgcct gcgggtgtgg aaaatgaaca atcaccaaac tgccgcgtac tgcgcttccc      360

gcctgtcagt ccactgctgg atgaagacgc ccgcttatgc tccctttcgg tttttgacgc      420

tttccgctta ttacagaatc tgttgaatgt accgaaggaa gaacgagaag caatgttctt      480

cggcggcctg ttctcttatg accttgtggc gggatttgaa aatttaccgc aactgtcagc      540

ggaaaatagc tgccctgatt tctgttttta tctcgctgaa acgctgatgg tgattgacca      600

tcagaaaaaa agcactcgta ttcaggccag cctgtttgct ccgaatgaag aagaaaaaca      660

acgtctcact gctcgcctga acgaactacg tcagcaactg accgaagccg cgccgccgct      720

gccggtggtt tccgtgccgc atatgcgttg tgaatgtaac cagagcgatg aagagttcgg      780

tggtgtagtg cgtttgttgc aaaaagcgat tcgcgccgga gaaattttcc aggtggtgcc      840

atctcgccgt ttctctctgc cctgcccgtc accgctggca gcctattacg tgctgaaaaa      900

gagtaatccc agcccgtaca tgttttttat gcaggataat gatttcaccc tgtttggcgc      960

gtcgccggaa agttcgctca agtatgacgc caccagccgc cagattgaga tttacccgat     1020

tgccggaaca cgtccacgcg gtcgtcgtgc cgatggttcg ctggacagag acctcgacag     1080

ccgcatcgaa ctggagatgc gtaccgatca taaagagctt tctgaacatc tgatgctggt     1140

ggatctcgcc cgtaatgacc tggcacgcat ttgcacaccc ggcagccgct acgtcgccga     1200

tctcaccaaa gttgaccgtt actcttacgt gatgcaccta gtctcccgcg ttgttggtga     1260

gctgcgccac gatctcgacg ccctgcacgc ttaccgcgcc tgtatgaata tggggacgtt     1320

aagcggtgca ccgaaagtac gcgctatgca gttaattgcc gaagcagaag gtcgtcgacg     1380

cggcagctac ggcggcgcgg taggttattt taccgcgcat ggcgatctcg acacctgcat     1440

tgtgatccgc tcggcgctgg tggaaaacgg tatcgccacc gtgcaagccg gtgctggcgt     1500

agtccttgat tctgttccgc agtcggaagc cgacgaaact cgtaataaag cccgcgctgt     1560

actgcgcgct attgccaccg cgcatcatgc acaggagacg ttctaatggc tgacattctg     1620

ctgctcgata atatcgactc ttttacgtac aacctggcag atcagttgcg cagcaatggt     1680

cataacgtgg tgatttaccg caaccatatt ccggcgcaga ccttaattga acgcctggcg     1740

acgatgagca atccggtgct gatgctttct cctggccccg gtgtgccgag cgaagccggt     1800

tgtatgccgg aactcctcac ccgcttgcgt ggcaagctgc caattattgg catttgcctc     1860

ggacatcagg cgattgtcga agcttacggg ggctatgtcg gtcaggcggg cgaaattctt     1920

cacggtaaag cgtcgagcat tgaacatgac ggtcaggcga tgtttgccgg attaacaaac     1980

ccgctgccag tggcgcgtta tcactcgctg gttggcagta acattccggc cggtttaacc     2040

atcaacgccc attttaatgg catggtgatg gcggtgcgtc acgatgcaga tcgcgtttgt     2100

ggattccagt tccatccgga atccattctt actacccagg gcgctcgcct gctggaacaa     2160

acgctggcct gggcgcagca gaaactagag ccaaccaaca cgctgcaacc gattctggaa     2220

aaactgtatc aggcacagac gcttagccaa caagaaagcc accagctgtt ttcagcggtg     2280

gtacgtggcg agctgaagcc ggaacaactg gcggcggcgc tggtgagcat gaaaattcgc     2340

ggtgaacacc cgaacgagat cgccggggca gcaaccgcgc tactggaaaa cgccgcgcca     2400

ttcccgcgcc cggattatct gtttgccgat atcgtcggta ctggcggtga cggcagcaac     2460

agcatcaata tttctaccgc cagtgcgttt gtcgccgcgg cctgcgggct gaaagtggcg     2520

aaacacggca accgtagcgt ctccagtaaa tccggctcgt cggatctgct ggcggcgttc     2580

ggtattaatc ttgatatgaa cgccgataaa tcgcgccagg cgctggatga gttaggcgtc     2640

tgtttcctct ttgcgccgaa gtatcacacc ggattccgcc atgcgatgcc ggttcgccag     2700

caactgaaaa cccgcactct gttcaacgtg ctgggaccat tgattaaccc ggcgcatccg     2760

ccgctggcgc taattggtgt ttatagtccg gaactggtgc tgccgattgc cgaaaccttg     2820

cgcgtgctgg ggtatcaacg cgcggcagtg gtgcacagcg gcgggatgga tgaagtttca     2880

ttacacgcgc cgacaatcgt tgccgaacta catgacggcg aaattaagag ctatcaattg     2940

accgctgaag attttggcct gacaccctac caccaggagc aattggcagg cggaacaccg     3000

gaagaaaacc gtgacatttt aacacgcttg ttacaaggta aaggcgacgc cgcccatgaa     3060

gcagccgtcg cggcgaatgt cgccatgtta atgcgcctgc atggccatga agatctgcaa     3120

gccaatgcgc aaaccgttct tgaggtactg cgcagtggtt ccgcttacga cagagtcacc     3180

gcactggcgg cacgagggta aatgatgcaa accgttttag cgaaaatcgt cgcagacaag     3240

gcgatttggg tagaaacccg caaagagcag caaccgctgg ccagttttca gaatgaggtt     3300

cagccgagca cgcgacattt ttatgatgca cttcagggcg cacgcacggc gtttattctg     3360

gagtgtaaaa aagcgtcgcc gtcaaaaggc gtgatccgtg atgatttcga tccggcacgc     3420

attgccgcca tttataaaca ttacgcttcg gcaatttcag tgctgactga tgagaaatat     3480

tttcagggga gctttgattt cctccccatc gtcagccaaa tcgccccgca gccgatttta     3540

tgtaaagact tcattatcga tccttaccag atctatctgg cgcgctatta ccaggccgat     3600

gcctgcttat taatgctttc agtactggat gacgaacaat atcgccagct tgcagccgtc     3660

gcccacagtc tggagatggg tgtgctgacc gaagtcagta atgaagagga actggagcgc     3720

gccattgcat tgggggcaaa ggtcgttggc atcaacaacc gcgatctgcg cgatttgtcg     3780

attgatctca accgtacccg cgagcttgcg ccgaaactgg ggcacaacgt gacggtaatc     3840

agcgaatccg gcatcaatac ttacgctcag gtgcgcgagt taagccactt cgctaacggc     3900

tttctgattg gttcggcgtt gatggcccat gacgatttga acgccgccgt gcgtcgggtg     3960

ttgctgggtg agaataaagt atgtggcctg acacgtgggc aagatgctaa agcagcttat     4020

gacgcgggcg cgatttacgg tgggttgatt tttgttgcga catcaccgcg ttgcgtcaac     4080

gttgaacagg cgcaggaagt gatggctgca gcaccgttgc agtatgttgg cgtgttccgc     4140

aatcacgata ttgccgatgt ggcggacaaa gctaaggtgt tatcgctggc ggcagtgcaa     4200

ctgcatggta atgaagatca gctgtatatc gacaatctgc gtgaggctct gccagcacac     4260

gtcgccatct ggaaggcttt aagtgtcggt gaaactcttc ccgcgcgcga ttttcagcac     4320

atcgataaat atgtattcga caacggtcag ggcgggagcg gacaacgttt cgactggtca     4380

ctattaaatg gtcaatcgct tggcaacgtt ctgctggcgg ggggcttagg cgcagataac     4440

tgcgtggaag cggcacaaac cggctgcgcc gggcttgatt ttaattctgc tgtagagtcg     4500

caaccgggta tcaaagacgc acgtcttttg gcctcggttt tccagacgct gcgcgcatat     4560

taaggaaagg aacaatgaca acattactta acccctattt tggtgagttt ggcggcatgt     4620

acgtgccaca aatcctgatg cctgctctgc gccagctgga agaagctttt gtcagcgcgc     4680

aaaaagatcc tgaatttcag gctcagttca acgacctgct gaaaaactat gccgggcgtc     4740

caaccgcgct gaccaaatgc cagaacatta cagccgggac gaacaccacg ctgtatctga     4800

agcgcgaaga tttgctgcac ggcggcgcgc ataaaactaa ccaggtgctc ggtcaggctt     4860

tactggcgaa gcggatgggt aaaactgaaa ttattgccga aaccggtgcc ggtcagcatg     4920

gcgtggcgtc ggcccttgcc agcgccctgc tcggcctgaa atgccgaatt tatatgggtg     4980

ccaaagacgt tgaacgccag tcgcccaacg ttttccggat gcgcttaatg ggtgcggaag     5040

tgatcccggt acatagcggt tccgcgaccc tgaaagatgc ctgtaatgag gcgctacgcg     5100

actggtccgg cagttatgaa accgcgcact atatgctggg taccgcagct ggcccgcatc     5160

cttacccgac cattgtgcgt gagtttcagc ggatgattgg cgaagaaacg aaagcgcaga     5220

ttctggaaag agaaggtcgc ctgccggatg ccgttatcgc ctgtgttggc ggtggttcga     5280

atgccatcgg tatgtttgca gatttcatca acgaaaccga cgtcggcctg attggtgtgg     5340

agcctggcgg ccacggtatc gaaactggcg agcacggcgc accgttaaaa catggtcgcg     5400

tgggcatcta tttcggtatg aaagcgccga tgatgcaaac cgaagacggg caaattgaag     5460

agtcttactc catttctgcc gggctggatt tcccgtccgt cggcccgcaa catgcgtatc     5520

tcaacagcac tggacgcgct gattacgtgt ctattaccga cgatgaagcc ctggaagcct     5580

ttaaaacgct ttgcctgcat gaagggatca tcccggcgct ggaatcctcc cacgccctgg     5640

cccatgcgct gaaaatgatg cgcgaaaatc cggaaaaaga gcagctactg gtggttaacc     5700

tttccggtcg cggcgataaa gacatcttca ccgttcacga tattttgaaa gcacgagggg     5760

aaatctgatg gaacgctacg aatctctgtt tgcccagttg aaggagcgca aagaaggcgc     5820

attcgttcct ttcgtcaccc tcggtgatcc gggcattgag cagtcgttga aaattatcga     5880

tacgctaatt gaagccggtg ctgacgcgct ggagttaggc atccccttct ccgacccact     5940

ggcggatggc ccgacgattc aaaacgccac actgcgtgct tttgcggcgg gagtaacccc     6000

ggcgcagtgc tttgagatgc tggcactcat tcgccagaag cacccgacca ttcccatcgg     6060

ccttttgatg tatgccaacc tggtgtttaa caaaggcatt gatgagtttt atgccgagtg     6120

cgagaaagtc ggcgtcgatt cggtgctggt tgccgatgtg cccgtggaag agtccgcgcc     6180

cttccgccag gccgcgttgc gtcataatgt cgcacctatc tttatttgcc cgccgaatgc     6240

cgacgatgat ttgctgcgcc agatagcctc ttacggtcgt ggttacacct atttgctgtc     6300

gcgagcgggc gtgaccggcg cagaaaaccg cgccgcgtta cccctcaatc atctggttgc     6360

gaagctgaaa gagtacaacg ctgcgcctcc attgcaggga tttggtattt ccgccccgga     6420

tcaggtaaaa gccgcgattg atgcaggagc tgcgggcgcg atttctggtt cggccatcgt     6480

taaaatcatc gagcaacata ttaatgagcc agagaaaatg ctggcggcac tgaaagcttt     6540

tgtacaaccg atgaaagcgg cgacgcgcag tta                                  6573


<210> 873
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61132"

<400> 873
tctagagaaa gacaggatta actagatg                                          28


<210> 874
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61136"

<400> 874
tctagagaaa gagctgagca actagatg                                          28


<210> 875
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61137"

<400> 875
tctagagaaa gagtagatca actagatg                                          28


<210> 876
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61138"

<400> 876
tctagagaaa gatatgaata actagatg                                          28


<210> 877
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61139"

<400> 877
tctagagaaa gattagagtc actagatg                                          28


<210> 878
<211> 6574
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="fbrS40FTrpE-DCBA"

<400> 878
ctctagaaat aattttgttt aactttaaga aggagatata catatgcaaa cacaaaaacc       60

gactctcgaa ctgctaacct gcgaaggcgc ttatcgcgac aacccgactg cgctttttca      120

ccagttgtgt ggggatcgtc cggcaacgct gctgctggaa ttcgcagata tcgacagcaa      180

agatgattta aaaagcctgc tgctggtaga cagtgcgctg cgcattacag cattaagtga      240

cactgtcaca atccaggcgc tttccggcaa tggagaagcc ctgttgacac tactggataa      300

cgccttgcct gcgggtgtgg aaaatgaaca atcaccaaac tgccgcgtac tgcgcttccc      360

gcctgtcagt ccactgctgg atgaagacgc ccgcttatgc tccctttcgg tttttgacgc      420

tttccgctta ttacagaatc tgttgaatgt accgaaggaa gaacgagaag caatgttctt      480

cggcggcctg ttctcttatg accttgtggc gggatttgaa aatttaccgc aactgtcagc      540

ggaaaatagc tgccctgatt tctgttttta tctcgctgaa acgctgatgg tgattgacca      600

tcagaaaaaa agcactcgta ttcaggccag cctgtttgct ccgaatgaag aagaaaaaca      660

acgtctcact gctcgcctga acgaactacg tcagcaactg accgaagccg cgccgccgct      720

gccggtggtt tccgtgccgc atatgcgttg tgaatgtaac cagagcgatg aagagttcgg      780

tggtgtagtg cgtttgttgc aaaaagcgat tcgcgccgga gaaattttcc aggtggtgcc      840

atctcgccgt ttctctctgc cctgcccgtc accgctggca gcctattacg tgctgaaaaa      900

gagtaatccc agcccgtaca tgttttttat gcaggataat gatttcaccc tgtttggcgc      960

gtcgccggaa agttcgctca agtatgacgc caccagccgc cagattgaga tttacccgat     1020

tgccggaaca cgtccacgcg gtcgtcgtgc cgatggttcg ctggacagag acctcgacag     1080

ccgcatcgaa ctggagatgc gtaccgatca taaagagctt tctgaacatc tgatgctggt     1140

ggatctcgcc cgtaatgacc tggcacgcat ttgcacaccc ggcagccgct acgtcgccga     1200

tctcaccaaa gttgaccgtt actcttacgt gatgcaccta gtctcccgcg ttgttggtga     1260

gctgcgccac gatctcgacg ccctgcacgc ttaccgcgcc tgtatgaata tggggacgtt     1320

aagcggtgca ccgaaagtac gcgctatgca gttaattgcc gaagcagaag gtcgtcgacg     1380

cggcagctac ggcggcgcgg taggttattt taccgcgcat ggcgatctcg acacctgcat     1440

tgtgatccgc tcggcgctgg tggaaaacgg tatcgccacc gtgcaagccg gtgctggcgt     1500

agtccttgat tctgttccgc agtcggaagc cgacgaaact cgtaataaag cccgcgctgt     1560

actgcgcgct attgccaccg cgcatcatgc acaggagacg ttctaatggc tgacattctg     1620

ctgctcgata atatcgactc ttttacgtac aacctggcag atcagttgcg cagcaatggt     1680

cataacgtgg tgatttaccg caaccatatt ccggcgcaga ccttaattga acgcctggcg     1740

acgatgagca atccggtgct gatgctttct cctggccccg gtgtgccgag cgaagccggt     1800

tgtatgccgg aactcctcac ccgcttgcgt ggcaagctgc caattattgg catttgcctc     1860

ggacatcagg cgattgtcga agcttacggg ggctatgtcg gtcaggcggg cgaaattctt     1920

cacggtaaag cgtcgagcat tgaacatgac ggtcaggcga tgtttgccgg attaacaaac     1980

ccgctgccag tggcgcgtta tcactcgctg gttggcagta acattccggc cggtttaacc     2040

atcaacgccc attttaatgg catggtgatg gcggtgcgtc acgatgcaga tcgcgtttgt     2100

ggattccagt tccatccgga atccattctt actacccagg gcgctcgcct gctggaacaa     2160

acgctggcct gggcgcagca gaaactagag ccaaccaaca cgctgcaacc gattctggaa     2220

aaactgtatc aggcacagac gcttagccaa caagaaagcc accagctgtt ttcagcggtg     2280

gtacgtggcg agctgaagcc ggaacaactg gcggcggcgc tggtgagcat gaaaattcgc     2340

ggtgaacacc cgaacgagat cgccggggca gcaaccgcgc tactggaaaa cgccgcgcca     2400

ttcccgcgcc cggattatct gtttgccgat atcgtcggta ctggcggtga cggcagcaac     2460

agcatcaata tttctaccgc cagtgcgttt gtcgccgcgg cctgcgggct gaaagtggcg     2520

aaacacggca accgtagcgt ctccagtaaa tccggctcgt cggatctgct ggcggcgttc     2580

ggtattaatc ttgatatgaa cgccgataaa tcgcgccagg cgctggatga gttaggcgtc     2640

tgtttcctct ttgcgccgaa gtatcacacc ggattccgcc atgcgatgcc ggttcgccag     2700

caactgaaaa cccgcactct gttcaacgtg ctgggaccat tgattaaccc ggcgcatccg     2760

ccgctggcgc taattggtgt ttatagtccg gaactggtgc tgccgattgc cgaaaccttg     2820

cgcgtgctgg ggtatcaacg cgcggcagtg gtgcacagcg gcgggatgga tgaagtttca     2880

ttacacgcgc cgacaatcgt tgccgaacta catgacggcg aaattaagag ctatcaattg     2940

accgctgaag attttggcct gacaccctac caccaggagc aattggcagg cggaacaccg     3000

gaagaaaacc gtgacatttt aacacgcttg ttacaaggta aaggcgacgc cgcccatgaa     3060

gcagccgtcg cggcgaatgt cgccatgtta atgcgcctgc atggccatga agatctgcaa     3120

gccaatgcgc aaaccgttct tgaggtactg cgcagtggtt ccgcttacga cagagtcacc     3180

gcactggcgg cacgagggta aatgatgcaa accgttttag cgaaaatcgt cgcagacaag     3240

gcgatttggg tagaaacccg caaagagcag caaccgctgg ccagttttca gaatgaggtt     3300

cagccgagca cgcgacattt ttatgatgca cttcagggcg cacgcacggc gtttattctg     3360

gagtgtaaaa aagcgtcgcc gtcaaaaggc gtgatccgtg atgatttcga tccggcacgc     3420

attgccgcca tttataaaca ttacgcttcg gcaatttcag tgctgactga tgagaaatat     3480

tttcagggga gctttgattt cctccccatc gtcagccaaa tcgccccgca gccgatttta     3540

tgtaaagact tcattatcga tccttaccag atctatctgg cgcgctatta ccaggccgat     3600

gcctgcttat taatgctttc agtactggat gacgaacaat atcgccagct tgcagccgtc     3660

gcccacagtc tggagatggg tgtgctgacc gaagtcagta atgaagagga actggagcgc     3720

gccattgcat tgggggcaaa ggtcgttggc atcaacaacc gcgatctgcg cgatttgtcg     3780

attgatctca accgtacccg cgagcttgcg ccgaaactgg ggcacaacgt gacggtaatc     3840

agcgaatccg gcatcaatac ttacgctcag gtgcgcgagt taagccactt cgctaacggc     3900

tttctgattg gttcggcgtt gatggcccat gacgatttga acgccgccgt gcgtcgggtg     3960

ttgctgggtg agaataaagt atgtggcctg acacgtgggc aagatgctaa agcagcttat     4020

gacgcgggcg cgatttacgg tgggttgatt tttgttgcga catcaccgcg ttgcgtcaac     4080

gttgaacagg cgcaggaagt gatggctgca gcaccgttgc agtatgttgg cgtgttccgc     4140

aatcacgata ttgccgatgt ggcggacaaa gctaaggtgt tatcgctggc ggcagtgcaa     4200

ctgcatggta atgaagatca gctgtatatc gacaatctgc gtgaggctct gccagcacac     4260

gtcgccatct ggaaggcttt aagtgtcggt gaaactcttc ccgcgcgcga ttttcagcac     4320

atcgataaat atgtattcga caacggtcag ggcgggagcg gacaacgttt cgactggtca     4380

ctattaaatg gtcaatcgct tggcaacgtt ctgctggcgg ggggcttagg cgcagataac     4440

tgcgtggaag cggcacaaac cggctgcgcc gggcttgatt ttaattctgc tgtagagtcg     4500

caaccgggta tcaaagacgc acgtcttttg gcctcggttt tccagacgct gcgcgcatat     4560

taaggaaagg aacaatgaca acattactta acccctattt tggtgagttt ggcggcatgt     4620

acgtgccaca aatcctgatg cctgctctgc gccagctgga agaagctttt gtcagcgcgc     4680

aaaaagatcc tgaatttcag gctcagttca acgacctgct gaaaaactat gccgggcgtc     4740

caaccgcgct gaccaaatgc cagaacatta cagccgggac gaacaccacg ctgtatctga     4800

agcgcgaaga tttgctgcac ggcggcgcgc ataaaactaa ccaggtgctc ggtcaggctt     4860

tactggcgaa gcggatgggt aaaactgaaa ttattgccga aaccggtgcc ggtcagcatg     4920

gcgtggcgtc ggcccttgcc agcgccctgc tcggcctgaa atgccgaatt tatatgggtg     4980

ccaaagacgt tgaacgccag tcgcccaacg ttttccggat gcgcttaatg ggtgcggaag     5040

tgatcccggt acatagcggt tccgcgaccc tgaaagatgc ctgtaatgag gcgctacgcg     5100

actggtccgg cagttatgaa accgcgcact atatgctggg taccgcagct ggcccgcatc     5160

cttacccgac cattgtgcgt gagtttcagc ggatgattgg cgaagaaacg aaagcgcaga     5220

ttctggaaag agaaggtcgc ctgccggatg ccgttatcgc ctgtgttggc ggtggttcga     5280

atgccatcgg tatgtttgca gatttcatca acgaaaccga cgtcggcctg attggtgtgg     5340

agcctggcgg ccacggtatc gaaactggcg agcacggcgc accgttaaaa catggtcgcg     5400

tgggcatcta tttcggtatg aaagcgccga tgatgcaaac cgaagacggg caaattgaag     5460

agtcttactc catttctgcc gggctggatt tcccgtccgt cggcccgcaa catgcgtatc     5520

tcaacagcac tggacgcgct gattacgtgt ctattaccga cgatgaagcc ctggaagcct     5580

ttaaaacgct ttgcctgcat gaagggatca tcccggcgct ggaatcctcc cacgccctgg     5640

cccatgcgct gaaaatgatg cgcgaaaatc cggaaaaaga gcagctactg gtggttaacc     5700

tttccggtcg cggcgataaa gacatcttca ccgttcacga tattttgaaa gcacgagggg     5760

aaatctgatg gaacgctacg aatctctgtt tgcccagttg aaggagcgca aagaaggcgc     5820

attcgttcct ttcgtcaccc tcggtgatcc gggcattgag cagtcgttga aaattatcga     5880

tacgctaatt gaagccggtg ctgacgcgct ggagttaggc atccccttct ccgacccact     5940

ggcggatggc ccgacgattc aaaacgccac actgcgtgct tttgcggcgg gagtaacccc     6000

ggcgcagtgc tttgagatgc tggcactcat tcgccagaag cacccgacca ttcccatcgg     6060

ccttttgatg tatgccaacc tggtgtttaa caaaggcatt gatgagtttt atgccgagtg     6120

cgagaaagtc ggcgtcgatt cggtgctggt tgccgatgtg cccgtggaag agtccgcgcc     6180

cttccgccag gccgcgttgc gtcataatgt cgcacctatc tttatttgcc cgccgaatgc     6240

cgacgatgat ttgctgcgcc agatagcctc ttacggtcgt ggttacacct atttgctgtc     6300

gcgagcgggc gtgaccggcg cagaaaaccg cgccgcgtta cccctcaatc atctggttgc     6360

gaagctgaaa gagtacaacg ctgcgcctcc attgcaggga tttggtattt ccgccccgga     6420

tcaggtaaaa gccgcgattg atgcaggagc tgcgggcgcg atttctggtt cggccatcgt     6480

taaaatcatc gagcaacata ttaatgagcc agagaaaatg ctggcggcac tgaaagcttt     6540

tgtacaaccg atgaaagcgg cgacgcgcag ttaa                                 6574


<210> 879
<211> 1562
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="fbrTrpE"

<400> 879
atgcaaacac aaaaaccgac tctcgaactg ctaacctgcg aaggcgctta tcgcgacaac       60

ccgactgcgc tttttcacca gttgtgtggg gatcgtccgg caacgctgct gctggaattc      120

gcagatatcg acagcaaaga tgatttaaaa agcctgctgc tggtagacag tgcgctgcgc      180

attacagcat taagtgacac tgtcacaatc caggcgcttt ccggcaatgg agaagccctg      240

ttgacactac tggataacgc cttgcctgcg ggtgtggaaa atgaacaatc accaaactgc      300

cgcgtactgc gcttcccgcc tgtcagtcca ctgctggatg aagacgcccg cttatgctcc      360

ctttcggttt ttgacgcttt ccgcttatta cagaatctgt tgaatgtacc gaaggaagaa      420

cgagaagcaa tgttcttcgg cggcctgttc tcttatgacc ttgtggcggg atttgaaaat      480

ttaccgcaac tgtcagcgga aaatagctgc cctgatttct gtttttatct cgctgaaacg      540

ctgatggtga ttgaccatca gaaaaaaagc actcgtattc aggccagcct gtttgctccg      600

aatgaagaag aaaaacaacg tctcactgct cgcctgaacg aactacgtca gcaactgacc      660

gaagccgcgc cgccgctgcc ggtggtttcc gtgccgcata tgcgttgtga atgtaaccag      720

agcgatgaag agttcggtgg tgtagtgcgt ttgttgcaaa aagcgattcg cgccggagaa      780

attttccagg tggtgccatc tcgccgtttc tctctgccct gcccgtcacc gctggcagcc      840

tattacgtgc tgaaaaagag taatcccagc ccgtacatgt tttttatgca ggataatgat      900

ttcaccctgt ttggcgcgtc gccggaaagt tcgctcaagt atgacgccac cagccgccag      960

attgagattt acccgattgc cggaacacgt ccacgcggtc gtcgtgccga tggttcgctg     1020

gacagagacc tcgacagccg catcgaactg gagatgcgta ccgatcataa agagctttct     1080

gaacatctga tgctggtgga tctcgcccgt aatgacctgg cacgcatttg cacacccggc     1140

agccgctacg tcgccgatct caccaaagtt gaccgttact cttacgtgat gcacctagtc     1200

tcccgcgttg ttggtgagct gcgccacgat ctcgacgccc tgcacgctta ccgcgcctgt     1260

atgaatatgg ggacgttaag cggtgcaccg aaagtacgcg ctatgcagtt aattgccgaa     1320

gcagaaggtc gtcgacgcgg cagctacggc ggcgcggtag gttattttac cgcgcatggc     1380

gatctcgaca cctgcattgt gatccgctcg gcgctggtgg aaaacggtat cgccaccgtg     1440

caagccggtg ctggcgtagt ccttgattct gttccgcagt cggaagccga cgaaactcgt     1500

aataaagccc gcgctgtact gcgcgctatt gccaccgcgc atcatgcaca ggagacgttc     1560

ta                                                                    1562


<210> 880
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_B0029"

<400> 880
tctagagttc acacaggaaa cctactagat g                                      31


<210> 881
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_B0030"

<400> 881
tctagagatt aaagaggaga aatactagat g                                      31


<210> 882
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_B0031"

<400> 882
tctagagtca cacaggaaac ctactagatg                                        30


<210> 883
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_B0032"

<400> 883
tctagagtca cacaggaaag tactagatg                                         29


<210> 884
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_B0033"

<400> 884
tctagagtca cacaggacta ctagatg                                           27


<210> 885
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_B0034"

<400> 885
tctagagaaa gaggagaaat actagatg                                          28


<210> 886
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_B0035"

<400> 886
tctagagatt aaagaggaga atactagatg                                        30


<210> 887
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_B0064"

<400> 887
tctagagaaa gaggggaaat actagatg                                          28


<210> 888
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="SYN23119 promoter"

<400> 888
ggaaaatttt tttaaaaaaa aaacttgaca gctagctcag tccttggtat aatgctagca       60

cgaa                                                                    64


<210> 889
<211> 94
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="SYN23119 promoter with RBS"

<400> 889
ggaaaatttt tttaaaaaaa aaacttgaca gctagctcag tccttggtat aatgctagca       60

cgaagtgaat tatataaaag tgggaggtgc ccga                                   94


<210> 890
<211> 1225
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Pseudomonas fluorescens, codon optimized for expression
      in E. coli, driven by the SYN23119 Construct can be expressed
      from a plasmid, e.g., p15 or can be integrated into the 
      chromosome, e.g., at the HA3/4 site"

<400> 890
ggaaaatttt tttaaaaaaa aaacttgaca gctagctcag tccttggtat aatgctagca       60

cgaagtgaat tatataaaag tgggaggtgc ccgaatgacg acccgaaatg attgcctagc      120

gttggatgca caggacagtc tggctccgct gcgccaacaa tttgcgctgc cggagggtgt      180

gatatacctg gatggcaatt cgctgggcgc acgtccggta gctgcgctgg ctcgcgcgca      240

ggctgtgatc gcagaagaat ggggcaacgg gttgatccgt tcatggaact ctgcgggctg      300

gcgtgatctg tctgaacgcc tgggtaatcg cctggctacc ctgattggtg cgcgcgatgg      360

ggaagtagtt gttactgata ccacctcgat taatctgttt aaagtgctgt cagcggcgct      420

gcgcgtgcaa gctacccgta gcccggagcg ccgtgttatc gtgactgaga cctcgaattt      480

cccgaccgac ctgtatattg cggaagggtt ggcggatatg ctgcaacaag gttacactct      540

gcgtttggtg gattcaccgg aagagctgcc acaggctata gatcaggaca ccgcggtggt      600

gatgctgacg cacgtaaatt ataaaaccgg ttatatgcac gacatgcagg ctctgaccgc      660

gttgagccac gagtgtgggg ctctggcgat ttgggatctg gcgcactctg ctggcgctgt      720

gccggtggac ctgcaccaag cgggcgcgga ctatgcgatt ggctgcacgt acaaatacct      780

gaatggcggc ccgggttcgc aagcgtttgt ttgggtttcg ccgcaactgt gcgacctggt      840

accgcagccg ctgtctggtt ggttcggcca tagtcgccaa ttcgcgatgg agccgcgcta      900

cgaaccttct aacggcattg ctcgctatct gtgcggcact cagcctatta ctagcttggc      960

tatggtggag tgcggcctgg atgtgtttgc gcagacggat atggcttcgc tgcgccgtaa     1020

aagtctggcg ctgactgatc tgttcatcga gctggttgaa caacgctgcg ctgcacacga     1080

actgaccctg gttactccac gtgaacacgc gaaacgcggc tctcacgtgt cttttgaaca     1140

ccccgagggt tacgctgtta ttcaagctct gattgatcgt ggcgtgatcg gcgattaccg     1200

tgagccacgt attatgcgtt tcggt                                           1225


<210> 891
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Lpp promoter from E. coli SEQ ID NO: 891"

<400> 891
ataagtgcct tcccatcaaa aaaatattct caacataaaa aactttgtgt aatacttgta       60

acgcta                                                                  66


<210> 892
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Lpp promoter from E. coli SEQ ID NO: 892"

<400> 892
ataagtgcct tcccatcaaa aaaatattct caacataaaa aactttgtgt aatacttgta       60

acgctagtga attatataaa agtgggaggt gcccga                                 96


<210> 893
<211> 1347
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Pseudomonas fluorescens kynureninase driven by Lpp promoter
      from E. coli SEQ ID NO: 893 Construct can be expressed from
      a plasmid, e.g., p15 or can be integrated into the 
      chromosome, e.g., at the HA3/4 site"

<400> 893
ataagtgcct tcccatcaaa aaaatattct caacataaaa aactttgtgt aatacttgta       60

acgctagtga attatataaa agtgggaggt gcccgaatga cgacccgaaa tgattgccta      120

gcgttggatg cacaggacag tctggctccg ctgcgccaac aatttgcgct gccggagggt      180

gtgatatacc tggatggcaa ttcgctgggc gcacgtccgg tagctgcgct ggctcgcgcg      240

caggctgtga tcgcagaaga atggggcaac gggttgatcc gttcatggaa ctctgcgggc      300

tggcgtgatc tgtctgaacg cctgggtaat cgcctggcta ccctgattgg tgcgcgcgat      360

ggggaagtag ttgttactga taccacctcg attaatctgt ttaaagtgct gtcagcggcg      420

ctgcgcgtgc aagctacccg tagcccggag cgccgtgtta tcgtgactga gacctcgaat      480

ttcccgaccg acctgtatat tgcggaaggg ttggcggata tgctgcaaca aggttacact      540

ctgcgtttgg tggattcacc ggaagagctg ccacaggcta tagatcagga caccgcggtg      600

gtgatgctga cgcacgtaaa ttataaaacc ggttatatgc acgacatgca ggctctgacc      660

gcgttgagcc acgagtgtgg ggctctggcg atttgggatc tggcgcactc tgctggcgct      720

gtgccggtgg acctgcacca agcgggcgcg gactatgcga ttggctgcac gtacaaatac      780

ctgaatggcg gcccgggttc gcaagcgttt gtttgggttt cgccgcaact gtgcgacctg      840

gtaccgcagc cgctgtctgg ttggttcggc catagtcgcc aattcgcgat ggagccgcgc      900

tacgaacctt ctaacggcat tgctcgctat ctgtgcggca ctcagcctat tactagcttg      960

gctatggtgg agtgcggcct ggatgtgttt gcgcagacgg atatggcttc gctgcgccgt     1020

aaaagtctgg cgctgactga tctgttcatc gagctggttg aacaacgctg cgctgcacac     1080

gaactgaccc tggttactcc acgtgaacac gcgaaacgcg gctctcacgt gtcttttgaa     1140

caccccgagg gttacgctgt tattcaagct ctgattgatc gtggcgtgat cggcgattac     1200

cgtgagccac gtattatgcg tttcggtttc actcctctgt atactacttt tacggaagtt     1260

tgggatgcag tacaaatcct gggcgaaatc ctggatcgta agacttgggc gcaggctcag     1320

tttcaggtgc gccactctgt tacttaa                                         1347


<210> 894
<211> 138
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="fliC-FliC20"

<400> 894
tgacggcgat tgagccgacg ggtggaaacc caaaacgtaa tcaacgtggg tactccttaa       60

attgggttcg aatggaccat ggcacaagtc attaatacca acagcctctc gctgatcact      120

caaaataata tcaacaag                                                    138


<210> 895
<211> 70
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="fliC-RBS"

<400> 895
tgacggcgat tgagccgacg ggtggaaacc caaaacgtaa tcaactacga acacttacag       60

gaggtaccca                                                              70


<210> 896
<211> 70
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="fliC-RBS"

<400> 896
tgacggcgat tgagccgacg ggtggaaacc caaaacgtaa tcaacaagta taaactctgg       60

gaggttccta                                                              70


<210> 897
<211> 70
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="fliC-RBS"

<400> 897
tgacggcgat tgagccgacg ggtggaaacc caaaacgtaa tcaactcaaa tcccttaata       60

aggaggtaaa                                                              70


<210> 898
<211> 106
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="RBS-phoA"

<400> 898
ctctagaaat aattttgttt aactttaaga aggagatata catatgaaac aaagcactat       60

tgcactggca ctcttaccgt tactgtttac ccctgtgaca aaagcg                     106


<210> 899
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="phoA"

<400> 899
atgaaacaaa gcactattgc actggcactc ttaccgttac tgtttacccc tgtgacaaaa       60

gcg                                                                     63


<210> 900
<211> 109
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="RBS-ompF"

<400> 900
ctctagaaat aattttgttt aactttaaga aggagatata catatgatga agcgcaatat       60

tctggcagtg atcgtccctg ctctgttagt agcaggtact gcaaacgct                  109


<210> 901
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="ompF"

<400> 901
atgatgaagc gcaatattct ggcagtgatc gtccctgctc tgttagtagc aggtactgca       60

aacgct                                                                  66


<210> 902
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RBS-cvaC"

<400> 902
ctctagaaat aattttgttt aactttaaga aggagatata catatgagaa ctctgactct       60

aaatgaatta gattctgttt ctggtggt                                          88


<210> 903
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="cvaC"

<400> 903
atgagaactc tgactctaaa tgaattagat tctgtttctg gtggt                       45


<210> 904
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RBS-phoA (Optimized)"

<400> 904
gacgccagag agttaagggg gttaaatgaa acaatcgacc atcgcattgg cgctgcttcc       60

tctattgttc acaccggtga caaaggca                                          88


<210> 905
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Optimized phoA"

<400> 905
atgaaacaat cgaccatcgc attggcgctg cttcctctat tgttcacacc ggtgacaaag       60

gca                                                                     63


<210> 906
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="RBS-TorA"

<400> 906
ctctagaaat aattttgttt aactttaaga aggagatata catatgaaca ataacgatct       60

ctttcaggca tcacgtcggc gttttctggc acaactcggc ggcttaaccg tcgccgggat      120

gctggggccg tcattgttaa cgccgcgacg tgcgactgcg                            160


<210> 907
<211> 117
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="TorA"

<400> 907
atgaacaata acgatctctt tcaggcatca cgtcggcgtt ttctggcaca actcggcggc       60

ttaaccgtcg ccgggatgct ggggccgtca ttgttaacgc cgcgacgtgc gactgcg         117


<210> 908
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="RBS-TorA alternate"

<400> 908
cccacattcg aggtactaaa tgaacaataa cgatctcttt caggcatcac gtcggcgttt       60

tctggcacaa ctcggcggct taaccgtcgc cgggatgctg gggacgtcat tgttaacgcc      120

gcgccgtgcg actgcggcgc aagcggcg                                         148


<210> 909
<211> 129
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="TorA (alternate)"

<400> 909
atgaacaata acgatctctt tcaggcatca cgtcggcgtt ttctggcaca actcggcggc       60

ttaaccgtcg ccgggatgct ggggacgtca ttgttaacgc cgcgccgtgc gactgcggcg      120

caagcggcg                                                              129


<210> 910
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="RBS-fdnG"

<400> 910
accctattac acacctaagg aggccaaata catggacgtc agtcgcagac aattttttaa       60

aatctgcgcg ggcggtatgg cgggaacaac agtagcagca ttgggctttg ccccgaagca      120

agcactggct                                                             130


<210> 911
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="fdnG"

<400> 911
atggacgtca gtcgcagaca attttttaaa atctgcgcgg gcggtatggc gggaacaaca       60

gtagcagcat tgggctttgc cccgaagcaa gcactggct                              99


<210> 912
<211> 168
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="RBS-dmsA"

<400> 912
tacgcaaaaa acataattta agagaggata aacatgaaaa cgaaaatccc tgatgcggta       60

ttggctgctg aggtgagtcg ccgtggtttg gtaaaaacga cagcgatcgg cggcctggca      120

atggccagca gcgcattaac attacctttt agtcggattg cgcacgct                   168


<210> 913
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="dmsA"

<400> 913
atgaaaacga aaatccctga tgcggtattg gctgctgagg tgagtcgccg tggtttggta       60

aaaacgacag cgatcggcgg cctggcaatg gccagcagcg cattaacatt accttttagt      120

cggattgcgc acgct                                                       135


<210> 914
<211> 712
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="TetR/TetA Promoter"

<400> 914
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcattgata gagttatttt accactccct atcagtgata gagaaaagtg aa              712


<210> 915
<211> 104
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="fliC Promoter"

<400> 915
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggt                       104


<210> 916
<211> 162
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FnrS Promoter"

<400> 916
ggtaccagtt gttcttattg gtggtgttgc tttatggttg catcgtagta aatggttgta       60

acaaaagcaa tttttccggc tgtctgtata caaaaacgcc gcaaagtttg agcgaagtca      120

ataaactctc tacccattca gggcaatatc tctcttggat cc                         162


<210> 917
<211> 358
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="DOM Construct Terminator"

<400> 917
cacatttccc cgaaaagtgc cgatggcccc ccgatggtag tgtggcccat gcgagagtag       60

ggaactgcca ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt      120

atctgttgtt tgtcggtgaa cgctctcctg agtaggacaa atccgccggg agcggatttg      180

aacgttgcga agcaacggcc cggagggtgg cgggcaggac gcccgccata aactgccagg      240

catcaaatta agcagaaggc catcctgacg gatggccttt ttgcgtggcc agtgccaagc      300

ttgcatgcag attgcagcat tacacgtctt gagcgattgt gtaggctgga gctgcttc        358


<210> 918
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FRT Site"

<400> 918
gaagttccta tactttctag agaataggaa cttcggaata ggaacttc                    48


<210> 919
<211> 1345
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Kanamycin Resistance Cassette (for integration in
      between FRT sites)"

<400> 919
aagatcccct cacgctgccg caagcactca gggcgcaagg gctgctaaag gaagcggaac       60

acgtagaaag ccagtccgca gaaacggtgc tgaccccgga tgaatgtcag ctactgggct      120

atctggacaa gggaaaacgc aagcgcaaag agaaagcagg tagcttgcag tgggcttaca      180

tggcgatagc tagactgggc ggttttatgg acagcaagcg aaccggaatt gccagctggg      240

gcgccctctg gtaaggttgg gaagccctgc aaagtaaact ggatggcttt cttgccgcca      300

aggatctgat ggcgcagggg atcaagatct gatcaagaga caggatgagg atcgtttcgc      360

atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc      420

ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca      480

gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg      540

caggacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg      600

ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag      660

gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg      720

cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc      780

atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa      840

gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac      900

ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat      960

ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac     1020

atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc     1080

ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt     1140

gacgagttct tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc     1200

tgccatcacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg     1260

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg     1320

cccaccccag cttcaaaagc gctct                                           1345


<210> 920
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human IL-12a construct with a N terminal OmpF
      secretion tag (sec-dependent secretion system)"

<400> 920
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210> 921
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human IL-12a construct with a N terminal PhoA
      secretion"

<400> 921
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
            20                  25                  30          


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
        35                  40                  45              


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
    50                  55                  60                  


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
65                  70                  75                  80  


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
                85                  90                  95      


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
            100                 105                 110         


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
        115                 120                 125             


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
    130                 135                 140                 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
145                 150                 155                 160 


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
                165                 170                 175     


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
            180                 185                 190         


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
        195                 200                 205             


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215             


<210> 922
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human IL-12a construct with a N terminal TorA
      secretion tag (sec-dependent secretion system)"

<400> 922
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Arg Asn Leu Pro Val Ala Thr Pro Asp 
        35                  40                  45              


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
    50                  55                  60                  


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
65                  70                  75                  80  


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
                85                  90                  95      


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
            100                 105                 110         


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
        115                 120                 125             


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
    130                 135                 140                 


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
145                 150                 155                 160 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
                165                 170                 175     


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
            180                 185                 190         


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
        195                 200                 205             


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
    210                 215                 220                 


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
225                 230                 235     


<210> 923
<211> 328
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human IL-12b construct with a N terminal OmpF
      secretion tag (sec-dependent secretion system)"

<400> 923
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210> 924
<211> 327
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human IL-12b construct with a N terminal PhoA
      secretion tag"

<400> 924
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser 
                325         


<210> 925
<211> 345
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human IL-12 construct with a N terminal TorA secretion
      tag (sec-dependent secretion system)"

<400> 925
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr 
        35                  40                  45              


Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val 
    50                  55                  60                  


Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp 
65                  70                  75                  80  


Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val 
                85                  90                  95      


Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu 
            100                 105                 110         


Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile 
        115                 120                 125             


Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr 
    130                 135                 140                 


Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp 
145                 150                 155                 160 


Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser 
                165                 170                 175     


Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu 
            180                 185                 190         


Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val 
        195                 200                 205             


Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro 
    210                 215                 220                 


Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr 
225                 230                 235                 240 


Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys 
                245                 250                 255     


Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser 
            260                 265                 270         


Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 
        275                 280                 285             


Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp 
    290                 295                 300                 


Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn 
305                 310                 315                 320 


Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp 
                325                 330                 335     


Ser Glu Trp Ala Ser Val Pro Cys Ser 
            340                 345 


<210> 926
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="murine IL-12a construct with a N terminal OmpF
      secretion tag (sec-dependent secretion system)"

<400> 926
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210> 927
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="murine IL-12a construct with a N terminal PhoA
      secretion tag"

<400> 927
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
            20                  25                  30          


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
        35                  40                  45              


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
    50                  55                  60                  


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
65                  70                  75                  80  


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
                85                  90                  95      


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
            100                 105                 110         


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
        115                 120                 125             


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
    130                 135                 140                 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
145                 150                 155                 160 


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
                165                 170                 175     


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
            180                 185                 190         


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
        195                 200                 205             


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215             


<210> 928
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="murine IL-12a construct with a N terminal TorA
      secretion tag (sec-dependent secretion system)"

<400> 928
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Arg Asn Leu Pro Val Ala Thr Pro Asp 
        35                  40                  45              


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
    50                  55                  60                  


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
65                  70                  75                  80  


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
                85                  90                  95      


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
            100                 105                 110         


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
        115                 120                 125             


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
    130                 135                 140                 


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
145                 150                 155                 160 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
                165                 170                 175     


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
            180                 185                 190         


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
        195                 200                 205             


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
    210                 215                 220                 


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
225                 230                 235     


<210> 929
<211> 335
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="murine IL-12b construct with a N terminal OmpF
      secretion tag (sec-dependent secretion system)"

<400> 929
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 335 


<210> 930
<211> 334
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="murine IL-12b construct with a N terminal PhoA
      secretion tag"

<400> 930
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
    50                  55                  60                  


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
65                  70                  75                  80  


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
                85                  90                  95      


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
            100                 105                 110         


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
        115                 120                 125             


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
    130                 135                 140                 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
145                 150                 155                 160 


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
                165                 170                 175     


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
            180                 185                 190         


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
        195                 200                 205             


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
    210                 215                 220                 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
225                 230                 235                 240 


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
            260                 265                 270         


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
        275                 280                 285             


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
    290                 295                 300                 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
305                 310                 315                 320 


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 


<210> 931
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="murine IL-12b construct with a N terminal TorA
      secretion tag (sec-dependent secretion system)"

<400> 931
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Met Trp Glu Leu Glu Lys Asp Val Tyr 
        35                  40                  45              


Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn 
    50                  55                  60                  


Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp 
65                  70                  75                  80  


Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val 
                85                  90                  95      


Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu 
            100                 105                 110         


Thr Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile 
        115                 120                 125             


Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys 
    130                 135                 140                 


Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val 
145                 150                 155                 160 


Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser 
                165                 170                 175     


Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu 
            180                 185                 190         


Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys 
        195                 200                 205             


Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu 
    210                 215                 220                 


Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr 
225                 230                 235                 240 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
                245                 250                 255     


Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr 
            260                 265                 270         


Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe 
        275                 280                 285             


Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly 
    290                 295                 300                 


Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val 
305                 310                 315                 320 


Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr 
                325                 330                 335     


Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
            340                 345                 350         


<210> 932
<211> 149
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human GMCSF construct with a N terminal OmpF secretion
      tag (sec-dependent secretion system)"

<400> 932
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr 
            20                  25                  30          


Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu 
        35                  40                  45              


Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val 
    50                  55                  60                  


Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg 
65                  70                  75                  80  


Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys 
                85                  90                  95      


Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln His Cys Pro Pro 
            100                 105                 110         


Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe 
        115                 120                 125             


Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp 
    130                 135                 140                 


Glu Pro Val Gln Glu 
145                 


<210> 933
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human GMCSF construct with a N terminal PhoA secretion
      tag"

<400> 933
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln 
            20                  25                  30          


Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn 
        35                  40                  45              


Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile 
    50                  55                  60                  


Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu 
65                  70                  75                  80  


Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly 
                85                  90                  95      


Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr 
            100                 105                 110         


Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys 
        115                 120                 125             


Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu 
    130                 135                 140                 


Pro Val Gln Glu 
145             


<210> 934
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human GMCSF construct with a N terminal TorA secretion
      tag (sec-dependent secretion system)"

<400> 934
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Ala Pro Ala Arg Ser Pro Ser Pro Ser 
        35                  40                  45              


Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala Arg Arg Leu 
    50                  55                  60                  


Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Thr Val Glu 
65                  70                  75                  80  


Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr 
                85                  90                  95      


Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu 
            100                 105                 110         


Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln His Cys Pro 
        115                 120                 125             


Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser 
    130                 135                 140                 


Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Phe Asp Cys 
145                 150                 155                 160 


Trp Glu Pro Val Gln Glu 
                165     


<210> 935
<211> 136
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human Il-15 construct with a N terminal OmpF secretion
      tag (sec-dependent secretion system)"

<400> 935
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser 
    130                 135     


<210> 936
<211> 135
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human Il-15 construct with a N terminal PhoA secretion
      tag"

<400> 936
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser 
    130                 135 


<210> 937
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human Il-15 construct with a N terminal TorA secretion
      tag (sec-dependent secretion system)"

<400> 937
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Asn Trp Val Asn Val Ile Ser Asp Leu 
        35                  40                  45              


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
    50                  55                  60                  


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
65                  70                  75                  80  


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
                85                  90                  95      


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
            100                 105                 110         


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
        115                 120                 125             


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
    130                 135                 140                 


Ile Val Gln Met Phe Ile Asn Thr Ser 
145                 150             


<210> 938
<211> 199
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human TNFa construct with a N terminal OmpF secretion
      tag (sec-dependent secretion system)"

<400> 938
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Gly Pro Gln Arg Glu Glu Phe Pro Arg Asp 
            20                  25                  30          


Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser Ser Arg 
        35                  40                  45              


Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala 
    50                  55                  60                  


Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala 
65                  70                  75                  80  


Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly 
                85                  90                  95      


Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro 
            100                 105                 110         


Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser 
        115                 120                 125             


Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln 
    130                 135                 140                 


Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile 
145                 150                 155                 160 


Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala 
                165                 170                 175     


Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val 
            180                 185                 190         


Tyr Phe Gly Ile Ile Ala Leu 
        195                 


<210> 939
<211> 198
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human TNFa construct with a N terminal PhoA secretion
      tag"

<400> 939
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Gly Pro Gln Arg Glu Glu Phe Pro Arg Asp Leu 
            20                  25                  30          


Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser Ser Arg Thr 
        35                  40                  45              


Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu 
    50                  55                  60                  


Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn 
65                  70                  75                  80  


Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu 
                85                  90                  95      


Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser 
            100                 105                 110         


Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr 
        115                 120                 125             


Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg 
    130                 135                 140                 


Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr 
145                 150                 155                 160 


Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu 
                165                 170                 175     


Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr 
            180                 185                 190         


Phe Gly Ile Ile Ala Leu 
        195             


<210> 940
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human TNFa construct with a N terminal TorA secretion
      tag (sec-dependent secretion system)"

<400> 940
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Gly Pro Gln Arg Glu Glu Phe Pro Arg 
        35                  40                  45              


Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser Ser 
    50                  55                  60                  


Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
65                  70                  75                  80  


Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
                85                  90                  95      


Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
            100                 105                 110         


Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
        115                 120                 125             


Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
    130                 135                 140                 


Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
145                 150                 155                 160 


Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
                165                 170                 175     


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
            180                 185                 190         


Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln 
        195                 200                 205             


Val Tyr Phe Gly Ile Ile Ala Leu 
    210                 215     


<210> 941
<211> 160
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human IFNg construct with a N terminal OmpF secretion
      tag (sec-dependent secretion system)"

<400> 941
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn 
            20                  25                  30          


Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly 
        35                  40                  45              


Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg 
    50                  55                  60                  


Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys 
65                  70                  75                  80  


Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys 
                85                  90                  95      


Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp 
            100                 105                 110         


Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln 
        115                 120                 125             


Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro 
    130                 135                 140                 


Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg Gly 
145                 150                 155                 160 


<210> 942
<211> 159
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human IFNg construct with a N terminal PhoA secretion
      tag"

<400> 942
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu 
            20                  25                  30          


Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr 
        35                  40                  45              


Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys 
    50                  55                  60                  


Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn 
65                  70                  75                  80  


Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu 
                85                  90                  95      


Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp 
            100                 105                 110         


Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg 
        115                 120                 125             


Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala 
    130                 135                 140                 


Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg Gly 
145                 150                 155                 


<210> 943
<211> 177
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="human IFNg construct with a N terminal TorA secretion
      tag (sec-dependent secretion system)"

<400> 943
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Gln Asp Pro Tyr Val Lys Glu Ala Glu 
        35                  40                  45              


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
    50                  55                  60                  


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
65                  70                  75                  80  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
                85                  90                  95      


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
            100                 105                 110         


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
        115                 120                 125             


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
    130                 135                 140                 


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
145                 150                 155                 160 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
                165                 170                 175     


Gly 
    


<210> 944

<400> 944
000


<210> 945

<400> 945
000


<210> 946

<400> 946
000


<210> 947

<400> 947
000


<210> 948

<400> 948
000


<210> 949

<400> 949
000


<210> 950

<400> 950
000


<210> 951

<400> 951
000


<210> 952

<400> 952
000


<210> 953
<211> 657
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="human IL-12a construct with a N terminal PhoA
      secretion tag"

<400> 953
atgaaacaga gcacaattgc tctggccttg ttgccattac tgtttacccc tgttactaag       60

gctaggaacc tgcctgtggc aacaccagac cctgggatgt tcccttgctt acatcattcc      120

cagaacctgt tgcgtgcggt gtctaacatg ctgcagaaag ccaggcagac gctggaattc      180

tacccatgca cttccgaaga gatagatcat gaagacatta cgaaagacaa aacctcaacg      240

gttgaagcat gcttacctct ggaattgact aagaatgaat cgtgcttaaa ctcaagagag      300

accagtttca tcactaatgg ctcttgctta gcgtcgcgca agaccagctt catgatggcg      360

ctctgcctaa gtagcatcta cgaggacctc aaaatgtacc aagttgaatt taaaactatg      420

aatgccaaac ttctaatgga cccaaaaaga cagatatttt tagatcagaa tatgcttgcg      480

gttattgacg aactcatgca ggcattgaat tttaattccg agacggtgcc acaaaaaagt      540

tctttggagg agccggactt ttacaagaca aaaatcaagc tgtgcatact tcttcacgca      600

ttcagaatac gggccgttac gatcgatcgc gtcatgtcgt atcttaatgc gagctga         657


<210> 954
<211> 987
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="human IL-12b construct with a N terminal PhoA
      secretion tag"

<400> 954
atgaagcaga gcacgatcgc attggcgttg ctaccgctgt tgtttacccc ggtcacaaaa       60

gccatctggg aactgaaaaa agatgtttat gtagttgaac tggattggta cccggatgca      120

cccggtgaga tggtggtttt gacctgcgac acgccggaag aagatggcat aacgtggacc      180

ctggatcaaa gctctgaagt tctgggttca ggtaagacat tgacgatcca agtaaaagaa      240

tttggcgacg caggtcagta cacctgccac aaaggtggcg aagttctgtc gcactcactc      300

ctgctcctgc acaaaaaaga ggatggcatc tggagtactg atatcctaaa ggatcaaaaa      360

gaacctaaaa acaaaacgtt cttgcgctgt gaagcgaaga actatagtgg tcgctttacg      420

tgctggtggt tgactaccat ttccaccgat ttgacctttt ctgttaagag ttcgcgcggc      480

tcgtcagatc cgcagggcgt tacttgcggt gcggcgacgc tgtcagctga gagagttcgt      540

ggggacaaca aagagtacga atatagtgta gaatgtcaag aggattcggc gtgcccggca      600

gcagaggagt ctctccccat tgaagttatg gtggacgcag tgcataaact gaaatatgag      660

aattacacat caagcttttt tattcgcgat atcatcaaac cggatcctcc aaaaaatctg      720

caactaaagc ccctgaaaaa ttcgcgccaa gttgaggtga gctgggaata tccggatact      780

tggtcgacac cgcattctta tttctcactg accttctgcg ttcaggttca aggtaaatca      840

aaacgagaaa aaaaggatcg cgtctttacc gacaaaacgt ctgctactgt aatctgccgc      900

aagaatgcgt caatttctgt acgtgcgcaa gatcgctact actctagtag ttggtctgaa      960

tgggcttcag tgccatgctc ctgatga                                          987


<210> 955
<211> 657
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="murine IL-12a construct with a N terminal PhoA
      secretion tag"

<400> 955
atgaaacaga gtacgatagc cctagccctg ttgccgctcc tgttcacccc cgttactaaa       60

gcacgtaacc ttccggtggc cacgccagat ccgggcatgt tcccgtgctt acaccattcc      120

cagaatctgc tgcgcgctgt gagtaatatg ctgcagaagg cgagacaaac tttggaattt      180

tacccgtgca cttcggagga gattgaccat gaggatatca caaaagacaa aaccagtaca      240

gtggaagcct gcctgcccct tgaactgact aaaaatgaga gttgtttaaa ttcacgcgaa      300

accagcttca ttactaacgg aagctgctta gcatcgcgga aaaccagttt tatgatggcc      360

ctttgccttt catctattta cgaggacctt aaaatgtatc aagttgaatt taagactatg      420

aacgcgaaac tgctaatgga tcccaagcga caaatctttc ttgatcaaaa tatgttggct      480

gttattgatg aactgatgca agccctgaat tttaactcag aaaccgtacc tcagaaatcg      540

agtttagaag aacccgattt ctacaaaact aaaatcaagt tgtgtatcct tttacatgcc      600

ttccggattc gggccgtcac tattgatcgc gtgatgtcgt acttgaatgc ctcctaa         657


<210> 956
<211> 1005
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="murine IL-12b construct with a N terminal PhoA
      secretion tag"

<400> 956
atgaaacaga gcacgatcgc acttgccctt ttgccgctgt tatttacccc agtgacgaaa       60

gccatgtggg aattggaaaa agacgtgtat gttgttgaag ttgactggac tccggacgcg      120

cctggtgaaa ctgttaatct gacttgtgat acaccggagg aagatgatat aacttggact      180

agcgatcaac gacacggcgt aatcggctct ggtaagactt tgaccattac tgtgaaggaa      240

ttcttggatg cggggcaata tacgtgtcat aaaggcggcg agacgctgtc acactctcac      300

ctgttgttac ataaaaaaga gaatggtata tggtctacgg agatcttgaa aaactttaaa      360

aacaaaactt ttttgaagtg tgaggctcca aactattctg gtcgctttac ctgtagttgg      420

ttggtgcaac gtaacatgga tctcaaattt aacataaagt cgtcttcgtc ttctcccgat      480

agccgagcgg ttacctgtgg catggctagt ttgtcggcgg agaaggtgac cttggatcaa      540

cgtgattatg aaaaatatag cgtttcgtgc caagaggacg ttacgtgccc taccgctgaa      600

gagactttgc cgattgaatt ggcactggaa gcacgacaac aaaataaata cgagaattac      660

tcaactagtt tcttcatccg agatatcata aaaccggacc ccccgaagaa tctgcaaatg      720

aaaccgctta aaaattcaca ggtagaggtt tcgtgggagt acccggatag ttggtctacg      780

cctcattcgt attttagcct gaaatttttc gttcgaatac agcgaaaaaa agagaagatg      840

aaagaaactg aagaagggtg taaccaaaaa ggtgcatttc tggtggagaa aactagcacc      900

gaggttcaat gcaaaggcgg taacgtgtgc gtacaagctc aagaccgtta ttataacagt      960

agctgttcta aatgggcttg cgtgccctgc cgcgtgagat catga                     1005


<210> 957
<211> 408
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="human Il-15 construct with a N terminal PhoA secretion
      tag"

<400> 957
atgaagcaat ctacgatcgc actagcgtta ctgccgttat tgtttactcc tgtgactaag       60

gctaattggg ttaatgttat atctgatttg aaaaaaatag aggatctgat tcaatcaatg      120

cacatagatg cgactctgta tactgagagc gatgtgcacc cgagttgcaa agttactgct      180

atgaaatgtt ttctgctgga gctgcaagtt atctctctgg agagtggtga tgcgtctatt      240

cacgatactg ttgagaatct gattattctg gctaataact cgctgtcaag taatgggaat      300

gttacggaat ctggctgtaa ggagtgtgaa gaattagaag aaaaaaatat taaagagttt      360

ctgcagagtt ttgtgcacat tgttcagatg tttatcaata ctagctga                   408


<210> 958
<211> 447
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="human GMCSF construct with a N terminal PhoA secretion
      tag"

<400> 958
atgaagcaat ctacgatcgc gttggcctta ctgcccctgt tattcacacc cgtgaccaaa       60

gcggcaccgg cccgcagccc atcaccgtca actcaacctt gggaacatgt aaatgctatt      120

caagaagctc gccgcctgtt gaatttgagt cgcgatactg cagcagagat gaatgagact      180

gtagaggtga tttcagaaat gtttgacctg caggagccga cttgtttgca aactcgcctg      240

gagctgtaca aacaaggcct gcgtggctcg ctgactaaac tgaaaggtcc tctgacgatg      300

atggcttctc attataaaca acactgcccg cctactccgg agacgtcttg cgcgacccag      360

ataattactt ttgaatcttt taaagagaat ctgaaagact ttctgctggt tatcccgttt      420

gattgttggg aaccggttca agaataa                                          447


<210> 959
<211> 597
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="human TNFa construct with a N terminal PhoA secretion
      tag"

<400> 959
atgaaacaat caacgatcgc tctggctctg cttccgctgc tctttactcc agttactaaa       60

gcgggtccgc agagggaaga attcccgcgc gatttgagcc tgatttcacc tcttgctcag      120

gctgtccgct cctcttcgcg taccccctcg gataaacctg tcgcgcacgt ggttgcgaac      180

ccgcaagcgg aagggcagct gcaatggtta aaccgccggg ctaatgcact gctggctaat      240

ggagttgagt tacgcgacaa ccaacttgtc gttccttcgg aagggctgta tctgatctat      300

tcacaggttc tctttaaagg gcagggttgc ccatcaaccc acgtgctcct gacacacacg      360

atcagtcgta tcgcggtatc ctatcagacg aaagttaacc tcctgtcagc gattaaatcg      420

ccgtgtcaga gagaaactcc agagggtgcg gaagctaaac cgtggtatga acctatttat      480

cttggtggag ttttccagtt ggaaaaaggt gatagactgt cggcagagat caatcgccct      540

gattacctgg atttcgctga gtcgggtcag gtttatttcg gaattattgc actgtga         597


<210> 960
<211> 480
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="human IFNg construct with a N terminal PhoA secretion
      tag"

<400> 960
atgaagcaat ctacgatagc actggcgttg ctgccgctgc tgttcacccc ggttaccaag       60

gcgcaggatc cttacgttaa agaagcagag aatctgaaaa aatactttaa tgcaggccac      120

agcgatgtgg cagataatgg cacgttattc ctgggcattc tgaaaaattg gaaagaagaa      180

tctgaccgga agatcatgca atctcagatc gtatcatttt atttcaagtt gtttaaaaac      240

ttcaaggatg accagtcgat tcaaaaatca gtggaaacga tcaaagaaga tatgaacgtt      300

aagttcttca actcaaataa aaaaaaacgc gatgatttcg aaaaactgac taattattcg      360

gtaactgatt tgaatgttca gcgcaaggcg attcatgaat tgattcaggt tatggcagaa      420

ctgtcgccag cggcaaaaac gggtaaacga aaacgttctc agatgttgtt tcgtggttga      480


<210> 961

<400> 961
000


<210> 962

<400> 962
000


<210> 963

<400> 963
000


<210> 964

<400> 964
000


<210> 965
<211> 2531
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ptet.phoA-hIL12b-phoA-hIL12a"

<400> 965
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaaataag tcataaatag ggagtccaaa atgaagcaga      780

gcacgatcgc attggcgttg ctaccgctgt tgtttacccc ggtcacaaaa gccatctggg      840

aactgaaaaa agatgtttat gtagttgaac tggattggta cccggatgca cccggtgaga      900

tggtggtttt gacctgcgac acgccggaag aagatggcat aacgtggacc ctggatcaaa      960

gctctgaagt tctgggttca ggtaagacat tgacgatcca agtaaaagaa tttggcgacg     1020

caggtcagta cacctgccac aaaggtggcg aagttctgtc gcactcactc ctgctcctgc     1080

acaaaaaaga ggatggcatc tggagtactg atatcctaaa ggatcaaaaa gaacctaaaa     1140

acaaaacgtt cttgcgctgt gaagcgaaga actatagtgg tcgctttacg tgctggtggt     1200

tgactaccat ttccaccgat ttgacctttt ctgttaagag ttcgcgcggc tcgtcagatc     1260

cgcagggcgt tacttgcggt gcggcgacgc tgtcagctga gagagttcgt ggggacaaca     1320

aagagtacga atatagtgta gaatgtcaag aggattcggc gtgcccggca gcagaggagt     1380

ctctccccat tgaagttatg gtggacgcag tgcataaact gaaatatgag aattacacat     1440

caagcttttt tattcgcgat atcatcaaac cggatcctcc aaaaaatctg caactaaagc     1500

ccctgaaaaa ttcgcgccaa gttgaggtga gctgggaata tccggatact tggtcgacac     1560

cgcattctta tttctcactg accttctgcg ttcaggttca aggtaaatca aaacgagaaa     1620

aaaaggatcg cgtctttacc gacaaaacgt ctgctactgt aatctgccgc aagaatgcgt     1680

caatttctgt acgtgcgcaa gatcgctact actctagtag ttggtctgaa tgggcttcag     1740

tgccatgctc ctgatgagaa accctacgga ggaggttaat ttatgaaaca gagcacaatt     1800

gctctggcct tgttgccatt actgtttacc cctgttacta aggctaggaa cctgcctgtg     1860

gcaacaccag accctgggat gttcccttgc ttacatcatt cccagaacct gttgcgtgcg     1920

gtgtctaaca tgctgcagaa agccaggcag acgctggaat tctacccatg cacttccgaa     1980

gagatagatc atgaagacat tacgaaagac aaaacctcaa cggttgaagc atgcttacct     2040

ctggaattga ctaagaatga atcgtgctta aactcaagag agaccagttt catcactaat     2100

ggctcttgct tagcgtcgcg caagaccagc ttcatgatgg cgctctgcct aagtagcatc     2160

tacgaggacc tcaaaatgta ccaagttgaa tttaaaacta tgaatgccaa acttctaatg     2220

gacccaaaaa gacagatatt tttagatcag aatatgcttg cggttattga cgaactcatg     2280

caggcattga attttaattc cgagacggtg ccacaaaaaa gttctttgga ggagccggac     2340

ttttacaaga caaaaatcaa gctgtgcata cttcttcacg cattcagaat acgggccgtt     2400

acgatcgatc gcgtcatgtc gtatcttaat gcgagctgaa aataaaacga aaggctcagt     2460

cgaaagactg ggcctttcgt tttatctgtt ggttccttat catctggcga atcggaccca     2520

caagagcact g                                                          2531


<210> 966
<211> 2549
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ptet.phoA-mIL12b-phoA-mIL12a"

<400> 966
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaatgtta cacatctaag gagaaacatt atgaaacaga      780

gcacgatcgc acttgccctt ttgccgctgt tatttacccc agtgacgaaa gccatgtggg      840

aattggaaaa agacgtgtat gttgttgaag ttgactggac tccggacgcg cctggtgaaa      900

ctgttaatct gacttgtgat acaccggagg aagatgatat aacttggact agcgatcaac      960

gacacggcgt aatcggctct ggtaagactt tgaccattac tgtgaaggaa ttcttggatg     1020

cggggcaata tacgtgtcat aaaggcggcg agacgctgtc acactctcac ctgttgttac     1080

ataaaaaaga gaatggtata tggtctacgg agatcttgaa aaactttaaa aacaaaactt     1140

ttttgaagtg tgaggctcca aactattctg gtcgctttac ctgtagttgg ttggtgcaac     1200

gtaacatgga tctcaaattt aacataaagt cgtcttcgtc ttctcccgat agccgagcgg     1260

ttacctgtgg catggctagt ttgtcggcgg agaaggtgac cttggatcaa cgtgattatg     1320

aaaaatatag cgtttcgtgc caagaggacg ttacgtgccc taccgctgaa gagactttgc     1380

cgattgaatt ggcactggaa gcacgacaac aaaataaata cgagaattac tcaactagtt     1440

tcttcatccg agatatcata aaaccggacc ccccgaagaa tctgcaaatg aaaccgctta     1500

aaaattcaca ggtagaggtt tcgtgggagt acccggatag ttggtctacg cctcattcgt     1560

attttagcct gaaatttttc gttcgaatac agcgaaaaaa agagaagatg aaagaaactg     1620

aagaagggtg taaccaaaaa ggtgcatttc tggtggagaa aactagcacc gaggttcaat     1680

gcaaaggcgg taacgtgtgc gtacaagctc aagaccgtta ttataacagt agctgttcta     1740

aatgggcttg cgtgccctgc cgcgtgagat catgagaaga agattattga agaggtccgc     1800

atgaaacaga gtacgatagc cctagccctg ttgccgctcc tgttcacccc cgttactaaa     1860

gcacgtaacc ttccggtggc cacgccagat ccgggcatgt tcccgtgctt acaccattcc     1920

cagaatctgc tgcgcgctgt gagtaatatg ctgcagaagg cgagacaaac tttggaattt     1980

tacccgtgca cttcggagga gattgaccat gaggatatca caaaagacaa aaccagtaca     2040

gtggaagcct gcctgcccct tgaactgact aaaaatgaga gttgtttaaa ttcacgcgaa     2100

accagcttca ttactaacgg aagctgctta gcatcgcgga aaaccagttt tatgatggcc     2160

ctttgccttt catctattta cgaggacctt aaaatgtatc aagttgaatt taagactatg     2220

aacgcgaaac tgctaatgga tcccaagcga caaatctttc ttgatcaaaa tatgttggct     2280

gttattgatg aactgatgca agccctgaat tttaactcag aaaccgtacc tcagaaatcg     2340

agtttagaag aacccgattt ctacaaaact aaaatcaagt tgtgtatcct tttacatgcc     2400

ttccggattc gggccgtcac tattgatcgc gtgatgtcgt acttgaatgc ctcctaaaaa     2460

taaaacgaaa ggctcagtcg aaagactggg cctttcgttt tatctgttgg ttccttatca     2520

tctggcgaat cggacccaca agagcactg                                       2549


<210> 967
<211> 1270
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ptet.phoA-IL15"

<400> 967
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaagatca actcaagata aggaggatcc atgaagcaat      780

ctacgatcgc actagcgtta ctgccgttat tgtttactcc tgtgactaag gctaattggg      840

ttaatgttat atctgatttg aaaaaaatag aggatctgat tcaatcaatg cacatagatg      900

cgactctgta tactgagagc gatgtgcacc cgagttgcaa agttactgct atgaaatgtt      960

ttctgctgga gctgcaagtt atctctctgg agagtggtga tgcgtctatt cacgatactg     1020

ttgagaatct gattattctg gctaataact cgctgtcaag taatgggaat gttacggaat     1080

ctggctgtaa ggagtgtgaa gaattagaag aaaaaaatat taaagagttt ctgcagagtt     1140

ttgtgcacat tgttcagatg tttatcaata ctagctgaaa ataaaacgaa aggctcagtc     1200

gaaagactgg gcctttcgtt ttatctgttg gttccttatc atctggcgaa tcggacccac     1260

aagagcactg                                                            1270


<210> 968
<211> 1309
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ptet.phoA-GMCSF"

<400> 968
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaagaaag caacaacata gggggaaaga atgaagcaat      780

ctacgatcgc gttggcctta ctgcccctgt tattcacacc cgtgaccaaa gcggcaccgg      840

cccgcagccc atcaccgtca actcaacctt gggaacatgt aaatgctatt caagaagctc      900

gccgcctgtt gaatttgagt cgcgatactg cagcagagat gaatgagact gtagaggtga      960

tttcagaaat gtttgacctg caggagccga cttgtttgca aactcgcctg gagctgtaca     1020

aacaaggcct gcgtggctcg ctgactaaac tgaaaggtcc tctgacgatg atggcttctc     1080

attataaaca acactgcccg cctactccgg agacgtcttg cgcgacccag ataattactt     1140

ttgaatcttt taaagagaat ctgaaagact ttctgctggt tatcccgttt gattgttggg     1200

aaccggttca agaataaaaa taaaacgaaa ggctcagtcg aaagactggg cctttcgttt     1260

tatctgttgg ttccttatca tctggcgaat cggacccaca agagcactg                 1309


<210> 969
<211> 1459
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ptet-phoA-TNFa"

<400> 969
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaacacaa cacagaaagg agggctgtcc atgaaacaat      780

caacgatcgc tctggctctg cttccgctgc tctttactcc agttactaaa gcgggtccgc      840

agagggaaga attcccgcgc gatttgagcc tgatttcacc tcttgctcag gctgtccgct      900

cctcttcgcg taccccctcg gataaacctg tcgcgcacgt ggttgcgaac ccgcaagcgg      960

aagggcagct gcaatggtta aaccgccggg ctaatgcact gctggctaat ggagttgagt     1020

tacgcgacaa ccaacttgtc gttccttcgg aagggctgta tctgatctat tcacaggttc     1080

tctttaaagg gcagggttgc ccatcaaccc acgtgctcct gacacacacg atcagtcgta     1140

tcgcggtatc ctatcagacg aaagttaacc tcctgtcagc gattaaatcg ccgtgtcaga     1200

gagaaactcc agagggtgcg gaagctaaac cgtggtatga acctatttat cttggtggag     1260

ttttccagtt ggaaaaaggt gatagactgt cggcagagat caatcgccct gattacctgg     1320

atttcgctga gtcgggtcag gtttatttcg gaattattgc actgtgaaaa taaaacgaaa     1380

ggctcagtcg aaagactggg cctttcgttt tatctgttgg ttccttatca tctggcgaat     1440

cggacccaca agagcactg                                                  1459


<210> 970
<211> 1342
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ptet-phoA-IFNg"

<400> 970
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaacacca ccaccacgag gaggtaaaaa atgaagcaat      780

ctacgatagc actggcgttg ctgccgctgc tgttcacccc ggttaccaag gcgcaggatc      840

cttacgttaa agaagcagag aatctgaaaa aatactttaa tgcaggccac agcgatgtgg      900

cagataatgg cacgttattc ctgggcattc tgaaaaattg gaaagaagaa tctgaccgga      960

agatcatgca atctcagatc gtatcatttt atttcaagtt gtttaaaaac ttcaaggatg     1020

accagtcgat tcaaaaatca gtggaaacga tcaaagaaga tatgaacgtt aagttcttca     1080

actcaaataa aaaaaaacgc gatgatttcg aaaaactgac taattattcg gtaactgatt     1140

tgaatgttca gcgcaaggcg attcatgaat tgattcaggt tatggcagaa ctgtcgccag     1200

cggcaaaaac gggtaaacga aaacgttctc agatgttgtt tcgtggttga aaataaaacg     1260

aaaggctcag tcgaaagact gggcctttcg ttttatctgt tggttcctta tcatctggcg     1320

aatcggaccc acaagagcac tg                                              1342


<210> 971

<400> 971
000


<210> 972

<400> 972
000


<210> 973

<400> 973
000


<210> 974

<400> 974
000


<210> 975
<211> 5100
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="ptet-J43scFv-V5-HIS ("

<400> 975
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagctat      240

ttaggtgaca ctatagaata ctcaagctat gcatcaagct tggtaccgag ctcggatcca      300

ctagtaacgg ccgccagtgt gctggaattc gcccttttaa gacccacttt cacatttaag      360

ttgtttttct aatccgcaga tgatcaattc aaggccgaat aagaaggctg gctctgcacc      420

ttggtgatca aataattcga tagcttgtcg taataatggc ggcatactat cagtagtagg      480

tgtttccctt tcttctttag cgacttgatg ctcttgatct tccaatacgc aacctaaagt      540

aaaatgcccc acagcgctga gtgcatataa tgcattctct agtgaaaaac cttgttggca      600

taaaaaggct aattgatttt cgagagtttc atactgtttt tctgtaggcc gtgtacctaa      660

atgtactttt gctccatcgc gatgacttag taaagcacat ctaaaacttt tagcgttatt      720

acgtaaaaaa tcttgccagc tttccccttc taaagggcaa aagtgagtat ggtgcctatc      780

taacatctca atggctaagg cgtcgagcaa agcccgctta ttttttacat gccaatacaa      840

tgtaggctgc tctacaccta gcttctgggc gagtttacgg gttgttaaac cttcgattcc      900

gacctcatta agcagctcta atgcgctgtt aatcacttta cttttatcta atctagacat      960

cattaattcc taatttttgt tgacactcta tcattgatag agttatttta ccactcccta     1020

tcagtgatag agaaaagtga aaggaggtaa attatgcaat tggaagttcg cctgttggag     1080

agcggtggtg gacttgtgaa acccgaggga agccttaaac tttcgtgcgt tgctagtggg     1140

ttcacatttt cagactattt catgtcctgg gtccgtcaag ccccgggaaa aggacttgaa     1200

tgggttgccc atatttacac caagagctat aactatgcca catactattc tggaagcgtt     1260

aaaggtcgtt ttaccatttc gcgtgacgac agccgttcta tggtgtattt gcagatgaat     1320

aaccttcgta cagaagatac ggctacttac tactgtactc gcgatggatc aggctatccc     1380

agtttagatt tctggggaca gggtactcag gttactgttt caagcggtgg aggcggctct     1440

ggcggtggtg ggagtggagg cggtggcagt tacgagctga cgcagccacc ctcggcaagt     1500

gtaaacgtgg gcgaaacggt gaaaattact tgttcggggg atcaactgcc caaatacttc     1560

gccgattggt ttcatcaacg ttccgatcag actattttac aagtgattta tgatgataac     1620

aaacgtccgt caggaatccc agagcgtatc agcggatcga gcagcggaac aacagcaact     1680

ttgaccatcc gcgatgtccg tgccgaagac gagggggact actattgttt ctctggatac     1740

gtggactcag acagcaagct gtatgttttt ggctcaggaa cacaactgac cgtactgggc     1800

aagggcgagc tcaattcgaa gcttgaaggt aagcctatcc ctaaccctct cctcggcctc     1860

gattctacgc gtaccggtca tcatcaccat caccattgag catgcggtct caggaggaag     1920

ggcgaattct gcagatatcc atcacactgg cggccgctcg agcatgcatc tagagggccc     1980

aattcgccct atagtgagtc gtattacaat tcactggccg tcgttttaca acgtcgtgac     2040

tgggaaaacc ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc     2100

tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctatac     2160

gtacggcagt ttaaggttta cacctataaa agagagagcc gttatcgtct gtttgtggat     2220

gtacagagtg atattattga cacgccgggg cgacggatgg tgatccccct ggccagtgca     2280

cgtctgctgt cagataaagt ctcccgtgaa ctttacccgg tggtgcatat cggggatgaa     2340

agctggcgca tgatgaccac cgatatggcc agtgtgccgg tctccgttat cggggaagaa     2400

gtggctgatc tcagccaccg cgaaaatgac atcaaaaacg ccattaacct gatgttctgg     2460

ggaatataaa tgtcaggcat gagattatca aaaaggatct tcacctagat ccttttcacg     2520

tagaaagcca gtccgcagaa acggtgctga ccccggatga atgtcagcta ctgggctatc     2580

tggacaaggg aaaacgcaag cgcaaagaga aagcaggtag cttgcagtgg gcttacatgg     2640

cgatagctag actgggcggt tttatggaca gcaagcgaac cggaattgcc agctggggcg     2700

ccctctggta aggttgggaa gccctgcaaa gtaaactgga tggctttctc gccgccaagg     2760

atctgatggc gcaggggatc aagctctgat caagagacag gatgaggatc gtttcgcatg     2820

attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag gctattcggc     2880

tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg     2940

caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcaa     3000

gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc     3060

gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat     3120

ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg     3180

cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa acatcgcatc     3240

gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaagag     3300

catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgagcat gcccgacggc     3360

gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt ggaaaatggc     3420

cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata     3480

gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga ccgcttcctc     3540

gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac     3600

gagttcttct gaattattaa cgcttacaat ttcctgatgc ggtattttct ccttacgcat     3660

ctgtgcggta tttcacaccg catacaggtg gcacttttcg gggaaatgtg cgcggaaccc     3720

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct     3780

gataaatgct tcaataatag cacgtgagga gggccaccat ggccaagttg accagtgccg     3840

ttccggtgct caccgcgcgc gacgtcgccg gagcggtcga gttctggacc gaccggctcg     3900

ggttctcccg ggacttcgtg gaggacgact tcgccggtgt ggtccgggac gacgtgaccc     3960

tgttcatcag cgcggtccag gaccaggtgg tgccggacaa caccctggcc tgggtgtggg     4020

tgcgcggcct ggacgagctg tacgccgagt ggtcggaggt cgtgtccacg aacttccggg     4080

acgcctccgg gccggccatg accgagatcg gcgagcagcc gtgggggcgg gagttcgccc     4140

tgcgcgaccc ggccggcaac tgcgtgcact tcgtggccga ggagcaggac tgacacgtgc     4200

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga     4260

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca     4320

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac     4380

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg     4440

taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag     4500

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac     4560

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     4620

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     4680

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     4740

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     4800

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     4860

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     4920

acgccagcaa cgcggccttt ttacggttcc tgggcttttg ctggcctttt gctcacatgt     4980

tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg     5040

ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag     5100


<210> 976
<211> 846
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="J43-Anti-PD1-scFv-V5-HIS"

<400> 976
atgcaattgg aagttcgcct gttggagagc ggtggtggac ttgtgaaacc cgagggaagc       60

cttaaacttt cgtgcgttgc tagtgggttc acattttcag actatttcat gtcctgggtc      120

cgtcaagccc cgggaaaagg acttgaatgg gttgcccata tttacaccaa gagctataac      180

tatgccacat actattctgg aagcgttaaa ggtcgtttta ccatttcgcg tgacgacagc      240

cgttctatgg tgtatttgca gatgaataac cttcgtacag aagatacggc tacttactac      300

tgtactcgcg atggatcagg ctatcccagt ttagatttct ggggacaggg tactcaggtt      360

actgtttcaa gcggtggagg cggctctggc ggtggtggga gtggaggcgg tggcagttac      420

gagctgacgc agccaccctc ggcaagtgta aacgtgggcg aaacggtgaa aattacttgt      480

tcgggggatc aactgcccaa atacttcgcc gattggtttc atcaacgttc cgatcagact      540

attttacaag tgatttatga tgataacaaa cgtccgtcag gaatcccaga gcgtatcagc      600

ggatcgagca gcggaacaac agcaactttg accatccgcg atgtccgtgc cgaagacgag      660

ggggactact attgtttctc tggatacgtg gactcagaca gcaagctgta tgtttttggc      720

tcaggaacac aactgaccgt actgggcaag ggcgagctca attcgaagct tgaaggtaag      780

cctatcccta accctctcct cggcctcgat tctacgcgta ccggtcatca tcaccatcac      840

cattga                                                                 846


<210> 977
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="scFvHeavy chain"

<400> 977
gaagttcgcc tgttggagag cggtggtgga cttgtgaaac ccgagggaag ccttaaactt       60

tcgtgcgttg ctagtgggtt cacattttca gactatttca tgtcctgggt ccgtcaagcc      120

ccgggaaaag gacttgaatg ggttgcccat atttacacca agagctataa ctatgccaca      180

tactattctg gaagcgttaa aggtcgtttt accatttcgc gtgacgacag ccgttctatg      240

gtgtatttgc agatgaataa ccttcgtaca gaagatacgg ctacttacta ctgtactcgc      300

gatggatcag gctatcccag tttagatttc tggggacagg gtactcaggt tactgtttca      360

agc                                                                    363


<210> 978
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="scFvLight chain"

<400> 978
tacgagctga cgcagccacc ctcggcaagt gtaaacgtgg gcgaaacggt gaaaattact       60

tgttcggggg atcaactgcc caaatacttc gccgattggt ttcatcaacg ttccgatcag      120

actattttac aagtgattta tgatgataac aaacgtccgt caggaatccc agagcgtatc      180

agcggatcga gcagcggaac aacagcaact ttgaccatcc gcgatgtccg tgccgaagac      240

gagggggact actattgttt ctctggatac gtggactcag acagcaagct gtatgttttt      300

ggctcaggaa cacaactgac cgtactgggc                                       330


<210> 979
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="scFvLinker"

<400> 979
ggtggaggcg gctctggcgg tggtgggagt ggaggcggtg gcagt                       45


<210> 980
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="J43-Anti-PD1-scFV polypeptide sequence"

<400> 980
Met Gln Leu Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Lys 
1               5                   10                  15      


Pro Glu Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
            20                  25                  30          


Ser Asp Tyr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Val Ala His Ile Tyr Thr Lys Ser Tyr Asn Tyr Ala Thr Tyr 
    50                  55                  60                  


Tyr Ser Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
65                  70                  75                  80  


Arg Ser Met Val Tyr Leu Gln Met Asn Asn Leu Arg Thr Glu Asp Thr 
                85                  90                  95      


Ala Thr Tyr Tyr Cys Thr Arg Asp Gly Ser Gly Tyr Pro Ser Leu Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Glu Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Val Asn Val Gly Glu Thr Val Lys Ile Thr Cys 
145                 150                 155                 160 


Ser Gly Asp Gln Leu Pro Lys Tyr Phe Ala Asp Trp Phe His Gln Arg 
                165                 170                 175     


Ser Asp Gln Thr Ile Leu Gln Val Ile Tyr Asp Asp Asn Lys Arg Pro 
            180                 185                 190         


Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser Ser Ser Gly Thr Thr Ala 
        195                 200                 205             


Thr Leu Thr Ile Arg Asp Val Arg Ala Glu Asp Glu Gly Asp Tyr Tyr 
    210                 215                 220                 


Cys Phe Ser Gly Tyr Val Asp Ser Asp Ser Lys Leu Tyr Val Phe Gly 
225                 230                 235                 240 


Ser Gly Thr Gln Leu Thr Val Leu Gly Lys Gly Glu Leu Asn Ser Lys 
                245                 250                 255     


Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
            260                 265                 270         


Arg Thr Gly His His His His His His 
        275                 280     


<210> 981
<211> 1668
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ptet-phoA-FLAG-J43-scFv-V5-HIS"

<400> 981
ttaagaccca ctttcacatt taagttgttt ttctaatccg cagatgatca attcaaggcc       60

gaataagaag gctggctctg caccttggtg atcaaataat tcgatagctt gtcgtaataa      120

tggcggcata ctatcagtag taggtgtttc cctttcttct ttagcgactt gatgctcttg      180

atcttccaat acgcaaccta aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt      240

ctctagtgaa aaaccttgtt ggcataaaaa ggctaattga ttttcgagag tttcatactg      300

tttttctgta ggccgtgtac ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc      360

acatctaaaa cttttagcgt tattacgtaa aaaatcttgc cagctttccc cttctaaagg      420

gcaaaagtga gtatggtgcc tatctaacat ctcaatggct aaggcgtcga gcaaagcccg      480

cttatttttt acatgccaat acaatgtagg ctgctctaca cctagcttct gggcgagttt      540

acgggttgtt aaaccttcga ttccgacctc attaagcagc tctaatgcgc tgttaatcac      600

tttactttta tctaatctag acataattaa ttcctaattt ttgttgacac tctatcattg      660

atagagttat tttaccactc cctatcagtg atagagaaaa gtgaaaggag gtaaattatg      720

actagtaaac aatcgaccat cgcattggcg ctgcttcctc tattgttcac accggtgaca      780

aaggcagtcg actataagga tgacgacgac aagcaattgg gcggtggcat ggaagttcgc      840

ctgttggaga gcggtggagg acttgtgaag cccgagggaa gccttaaact ttcgtgcgtt      900

gctagtgggt tcacattttc agactatttc atgtcctggg tccgtcaagc cccgggaaaa      960

ggacttgaat gggttgccca tatttacacc aagagctata actatgccac atactattct     1020

ggaagcgtta aaggtcgttt taccatttcg cgtgacgaca gccgttctat ggtgtatttg     1080

cagatgaata accttcgtac agaagatacg gctacttact actgtactcg cgatggatca     1140

ggctatccca gtttagattt ctggggacag ggtactcagg ttactgtttc aagcggtgga     1200

ggcggctctg gcggtggtgg gagtggaggc ggtggcagtt acgagctgac gcagccgccc     1260

tcggcaagtg taaacgtggg cgaaacggtg aaaattactt gttcggggga tcaactgccc     1320

aaatacttcg ccgattggtt tcatcaacgt tccgatcaga ctattttaca agtgatttat     1380

gatgataaca aacgtccgtc aggaatccca gagcgtatca gcggatcgag cagcggaaca     1440

acagcaactt tgaccatccg cgatgtccgt gccgaagacg agggggacta ctattgtttc     1500

tctggatacg tggactcaga cagcaagctg tatgtttttg gctcaggaac acaactgacc     1560

gtactgggca agggcgagct caattcgaag cttgaaggta agcctatccc taaccctctc     1620

ctcggactcg attctacggg atccggtcat catcaccatc accattga                  1668


<210> 982
<211> 313
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="phoA-FLAG-J43-scFv-V5-HIS"

<400> 982
Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu Gly 
            20                  25                  30          


Gly Gly Met Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Lys 
        35                  40                  45              


Pro Glu Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
    50                  55                  60                  


Ser Asp Tyr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
65                  70                  75                  80  


Glu Trp Val Ala His Ile Tyr Thr Lys Ser Tyr Asn Tyr Ala Thr Tyr 
                85                  90                  95      


Tyr Ser Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
            100                 105                 110         


Arg Ser Met Val Tyr Leu Gln Met Asn Asn Leu Arg Thr Glu Asp Thr 
        115                 120                 125             


Ala Thr Tyr Tyr Cys Thr Arg Asp Gly Ser Gly Tyr Pro Ser Leu Asp 
    130                 135                 140                 


Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Glu Leu Thr Gln 
                165                 170                 175     


Pro Pro Ser Ala Ser Val Asn Val Gly Glu Thr Val Lys Ile Thr Cys 
            180                 185                 190         


Ser Gly Asp Gln Leu Pro Lys Tyr Phe Ala Asp Trp Phe His Gln Arg 
        195                 200                 205             


Ser Asp Gln Thr Ile Leu Gln Val Ile Tyr Asp Asp Asn Lys Arg Pro 
    210                 215                 220                 


Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser Ser Ser Gly Thr Thr Ala 
225                 230                 235                 240 


Thr Leu Thr Ile Arg Asp Val Arg Ala Glu Asp Glu Gly Asp Tyr Tyr 
                245                 250                 255     


Cys Phe Ser Gly Tyr Val Asp Ser Asp Ser Lys Leu Tyr Val Phe Gly 
            260                 265                 270         


Ser Gly Thr Gln Leu Thr Val Leu Gly Lys Gly Glu Leu Asn Ser Lys 
        275                 280                 285             


Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
    290                 295                 300                 


Gly Ser Gly His His His His His His 
305                 310             


<210> 983
<211> 1674
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ptet-ompF-FLAG-J43-scFv-V5-HIS"

<400> 983
ttaagaccca ctttcacatt taagttgttt ttctaatccg cagatgatca attcaaggcc       60

gaataagaag gctggctctg caccttggtg atcaaataat tcgatagctt gtcgtaataa      120

tggcggcata ctatcagtag taggtgtttc cctttcttct ttagcgactt gatgctcttg      180

atcttccaat acgcaaccta aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt      240

ctctagtgaa aaaccttgtt ggcataaaaa ggctaattga ttttcgagag tttcatactg      300

tttttctgta ggccgtgtac ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc      360

acatctaaaa cttttagcgt tattacgtaa aaaatcttgc cagctttccc cttctaaagg      420

gcaaaagtga gtatggtgcc tatctaacat ctcaatggct aaggcgtcga gcaaagcccg      480

cttatttttt acatgccaat acaatgtagg ctgctctaca cctagcttct gggcgagttt      540

acgggttgtt aaaccttcga ttccgacctc attaagcagc tctaatgcgc tgttaatcac      600

tttactttta tctaatctag acatcattaa ttcctaattt ttgttgacac tctatcattg      660

atagagttat tttaccactc cctatcagtg atagagaaaa gtgaaaggag gtaaattatg      720

actagtatga tgaagcgtaa catcttagcc gttattgtcc ccgcattgct tgtggccggg      780

acggctaacg cagtcgacta taaggatgac gacgacaagc aattgggcgg tggcatggaa      840

gttcgcctgt tggagagcgg tggaggactt gtgaagcccg agggaagcct taaactttcg      900

tgcgttgcta gtgggttcac attttcagac tatttcatgt cctgggtccg tcaagccccg      960

ggaaaaggac ttgaatgggt tgcccatatt tacaccaaga gctataacta tgccacatac     1020

tattctggaa gcgttaaagg tcgttttacc atttcgcgtg acgacagccg ttctatggtg     1080

tatttgcaga tgaataacct tcgtacagaa gatacggcta cttactactg tactcgcgat     1140

ggatcaggct atcccagttt agatttctgg ggacagggta ctcaggttac tgtttcaagc     1200

ggtggaggcg gctctggcgg tggtgggagt ggaggcggtg gcagttacga gctgacgcag     1260

ccgccctcgg caagtgtaaa cgtgggcgaa acggtgaaaa ttacttgttc gggggatcaa     1320

ctgcccaaat acttcgccga ttggtttcat caacgttccg atcagactat tttacaagtg     1380

atttatgatg ataacaaacg tccgtcagga atcccagagc gtatcagcgg atcgagcagc     1440

ggaacaacag caactttgac catccgcgat gtccgtgccg aagacgaggg ggactactat     1500

tgtttctctg gatacgtgga ctcagacagc aagctgtatg tttttggctc aggaacacaa     1560

ctgaccgtac tgggcaaggg cgagctcaat tcgaagcttg aaggtaagcc tatccctaac     1620

cctctcctcg gactcgattc tacgggatcc ggtcatcatc accatcacca ttga           1674


<210> 984
<211> 315
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="ompF-FLAG-J43-scFv-V5-HIS"

<400> 984
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln 
            20                  25                  30          


Leu Gly Gly Gly Met Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu 
        35                  40                  45              


Val Lys Pro Glu Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe 
    50                  55                  60                  


Thr Phe Ser Asp Tyr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
65                  70                  75                  80  


Gly Leu Glu Trp Val Ala His Ile Tyr Thr Lys Ser Tyr Asn Tyr Ala 
                85                  90                  95      


Thr Tyr Tyr Ser Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            100                 105                 110         


Asp Ser Arg Ser Met Val Tyr Leu Gln Met Asn Asn Leu Arg Thr Glu 
        115                 120                 125             


Asp Thr Ala Thr Tyr Tyr Cys Thr Arg Asp Gly Ser Gly Tyr Pro Ser 
    130                 135                 140                 


Leu Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Glu Leu 
                165                 170                 175     


Thr Gln Pro Pro Ser Ala Ser Val Asn Val Gly Glu Thr Val Lys Ile 
            180                 185                 190         


Thr Cys Ser Gly Asp Gln Leu Pro Lys Tyr Phe Ala Asp Trp Phe His 
        195                 200                 205             


Gln Arg Ser Asp Gln Thr Ile Leu Gln Val Ile Tyr Asp Asp Asn Lys 
    210                 215                 220                 


Arg Pro Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser Ser Ser Gly Thr 
225                 230                 235                 240 


Thr Ala Thr Leu Thr Ile Arg Asp Val Arg Ala Glu Asp Glu Gly Asp 
                245                 250                 255     


Tyr Tyr Cys Phe Ser Gly Tyr Val Asp Ser Asp Ser Lys Leu Tyr Val 
            260                 265                 270         


Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Gly Lys Gly Glu Leu Asn 
        275                 280                 285             


Ser Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
    290                 295                 300                 


Ser Thr Gly Ser Gly His His His His His His 
305                 310                 315 


<210> 985
<211> 1668
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ptet-PelB-FLAG-J43-scFv-V5-HIS"

<400> 985
ttaagaccca ctttcacatt taagttgttt ttctaatccg cagatgatca attcaaggcc       60

gaataagaag gctggctctg caccttggtg atcaaataat tcgatagctt gtcgtaataa      120

tggcggcata ctatcagtag taggtgtttc cctttcttct ttagcgactt gatgctcttg      180

atcttccaat acgcaaccta aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt      240

ctctagtgaa aaaccttgtt ggcataaaaa ggctaattga ttttcgagag tttcatactg      300

tttttctgta ggccgtgtac ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc      360

acatctaaaa cttttagcgt tattacgtaa aaaatcttgc cagctttccc cttctaaagg      420

gcaaaagtga gtatggtgcc tatctaacat ctcaatggct aaggcgtcga gcaaagcccg      480

cttatttttt acatgccaat acaatgtagg ctgctctaca cctagcttct gggcgagttt      540

acgggttgtt aaaccttcga ttccgacctc attaagcagc tctaatgcgc tgttaatcac      600

tttactttta tctaatctag acatcattaa ttcctaattt ttgttgacac tctatcattg      660

atagagttat tttaccactc cctatcagtg atagagaaaa gtgaaaggag gtaaattatg      720

actagtaaat atcttcttcc aacggctgct gctggtttat tgcttcttgc cgcccagcct      780

gcgatggctg tcgactataa ggatgacgac gacaagcaat tgggcggtgg catggaagtt      840

cgcctgttgg agagcggtgg aggacttgtg aagcccgagg gaagccttaa actttcgtgc      900

gttgctagtg ggttcacatt ttcagactat ttcatgtcct gggtccgtca agccccggga      960

aaaggacttg aatgggttgc ccatatttac accaagagct ataactatgc cacatactat     1020

tctggaagcg ttaaaggtcg ttttaccatt tcgcgtgacg acagccgttc tatggtgtat     1080

ttgcagatga ataaccttcg tacagaagat acggctactt actactgtac tcgcgatgga     1140

tcaggctatc ccagtttaga tttctgggga cagggtactc aggttactgt ttcaagcggt     1200

ggaggcggct ctggcggtgg tgggagtgga ggcggtggca gttacgagct gacgcagccg     1260

ccctcggcaa gtgtaaacgt gggcgaaacg gtgaaaatta cttgttcggg ggatcaactg     1320

cccaaatact tcgccgattg gtttcatcaa cgttccgatc agactatttt acaagtgatt     1380

tatgatgata acaaacgtcc gtcaggaatc ccagagcgta tcagcggatc gagcagcgga     1440

acaacagcaa ctttgaccat ccgcgatgtc cgtgccgaag acgaggggga ctactattgt     1500

ttctctggat acgtggactc agacagcaag ctgtatgttt ttggctcagg aacacaactg     1560

accgtactgg gcaagggcga gctcaattcg aagcttgaag gtaagcctat ccctaaccct     1620

ctcctcggac tcgattctac gggatccggt catcatcacc atcaccat                  1668


<210> 986
<211> 314
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="PelB-FLAG-J43-scFv-V5-HIS"

<400> 986
Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gln Pro Ala Met Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu 
            20                  25                  30          


Gly Gly Gly Met Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val 
        35                  40                  45              


Lys Pro Glu Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr 
    50                  55                  60                  


Phe Ser Asp Tyr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
65                  70                  75                  80  


Leu Glu Trp Val Ala His Ile Tyr Thr Lys Ser Tyr Asn Tyr Ala Thr 
                85                  90                  95      


Tyr Tyr Ser Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
            100                 105                 110         


Ser Arg Ser Met Val Tyr Leu Gln Met Asn Asn Leu Arg Thr Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Tyr Cys Thr Arg Asp Gly Ser Gly Tyr Pro Ser Leu 
    130                 135                 140                 


Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Glu Leu Thr 
                165                 170                 175     


Gln Pro Pro Ser Ala Ser Val Asn Val Gly Glu Thr Val Lys Ile Thr 
            180                 185                 190         


Cys Ser Gly Asp Gln Leu Pro Lys Tyr Phe Ala Asp Trp Phe His Gln 
        195                 200                 205             


Arg Ser Asp Gln Thr Ile Leu Gln Val Ile Tyr Asp Asp Asn Lys Arg 
    210                 215                 220                 


Pro Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser Ser Ser Gly Thr Thr 
225                 230                 235                 240 


Ala Thr Leu Thr Ile Arg Asp Val Arg Ala Glu Asp Glu Gly Asp Tyr 
                245                 250                 255     


Tyr Cys Phe Ser Gly Tyr Val Asp Ser Asp Ser Lys Leu Tyr Val Phe 
            260                 265                 270         


Gly Ser Gly Thr Gln Leu Thr Val Leu Gly Lys Gly Glu Leu Asn Ser 
        275                 280                 285             


Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
    290                 295                 300                 


Thr Gly Ser Gly His His His His His His 
305                 310                 


<210> 987
<211> 5708
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="p15A-Kan-ptet-Invasin-FLAG-J43scFv-V5-HIS"

<400> 987
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttt      900

aagacccact ttcacattta agttgttttt ctaatccgca tatgatcaat tcaaggccga      960

ataagaaggc tggctctgca ccttggtgat caaataattc gatagcttgt cgtaataatg     1020

gcggcatact atcagtagta ggtgtttccc tttcttcttt agcgacttga tgctcttgat     1080

cttccaatac gcaacctaaa gtaaaatgcc ccacagcgct gagtgcatat aatgcattct     1140

ctagtgaaaa accttgttgg cataaaaagg ctaattgatt ttcgagagtt tcatactgtt     1200

tttctgtagg ccgtgtacct aaatgtactt ttgctccatc gcgatgactt agtaaagcac     1260

atctaaaact tttagcgtta ttacgtaaaa aatcttgcca gctttcccct tctaaagggc     1320

aaaagtgagt atggtgccta tctaacatct caatggctaa ggcgtcgagc aaagcccgct     1380

tattttttac atgccaatac aatgtaggct gctctacacc tagcttctgg gcgagtttac     1440

gggttgttaa accttcgatt ccgacctcat taagcagctc taatgcgctg ttaatcactt     1500

tacttttatc taatctagac atcattaatt cctaattttt gttgacactc tatcattgat     1560

agagttattt taccactccc tatcagtgat agagaaaagt gaaaggaggt aaattatgac     1620

tagtatggtt ttccaaccca tcagcgaatt tttgctgatt cgtaacgctg ggatgtccat     1680

gtattttaac aagatcattt cttttaacat catttcacgt atcgttattt gcatttttct     1740

tatctgtggt atgttcatgg ccggtgcatc tgaaaagtat gatgcaaacg caccccaaca     1800

ggtgcagcca tactcggttt catcatcagc gttcgagaat ctgcacccca ataacgagat     1860

ggagtcgagt atcaaccctt ttagtgcttc ggacaccgag cgtaatgcag ctatcatcga     1920

tcgtgctaac aaggaacaag aaacggaagc agtcaacaaa atgatctcca ctggcgctcg     1980

tttagctgcc agcggtcgcg cgtccgatgt ggcgcacagt atggtagggg atgcggtcaa     2040

ccaggagatt aaacaatggc tgaatcgctt cggcactgct caagtgaatt taaattttga     2100

caagaacttc tcgttaaagg agtcttcgct tgactggttg gccccatggt acgattcggc     2160

gtcattcctt ttcttttctc agttgggcat ccgtaacaag gacagtcgta atacacttaa     2220

ccttggtgtt ggcattcgca cattagaaaa tggttggttg tatggcctga acacctttta     2280

cgacaatgac ttaacgggac acaatcaccg tatcgggctg ggcgccgagg cgtggactga     2340

ctacttgcag ttagccgcga atgggtactt ccgtcttaat ggttggcact cttcccgtga     2400

cttcagcgac tacaaagaac gccctgctac cgggggagat ttgcgtgcga atgcgtacct     2460

gcccgctctt ccgcaacttg gcgggaagtt aatgtatgag cagtatactg gggaacgcgt     2520

ggctctgttc ggaaaggaca acctgcagcg caacccatac gctgtcactg cgggtatcaa     2580

ctatacgcca gttccgttgc tgacggtcgg cgtggatcaa cgtatgggga agtcgagtaa     2640

acatgaaacg caatggaatt tacaaatgaa ctatcgctta ggggagagtt tccaaagtca     2700

gcttagccct tcggcggtcg cagggactcg tttgcttgct gagtcccgct acaacctggt     2760

tgatcgcaat aacaatatcg tactggaata ccagaaacaa caagtggtta agctgacgtt     2820

gagccctgcg accatcagtg gattgcccgg acaagtttac caggtaaatg cccaggtcca     2880

gggggcctct gcggttcgcg aaattgtctg gtcagacgca gaattaatcg ctgcaggagg     2940

caccttaacg ccactttcca ctacacaatt caatttagtc cttcccccat acaaacgtac     3000

cgcccaggta tcgcgcgtaa ctgatgactt aactgctaat ttttattcac tgtcggcgtt     3060

agcagttgac catcaaggca accgtagtaa ttccttcaca ttatctgtaa cggtgcagca     3120

gccgcaactg acgcttaccg cagcggtcat tggtgatggg gccccagcta atgggaaaac     3180

cgcaatcact gtcgagttca cagttgcaga ttttgaaggc aagccgctgg cgggtcagga     3240

ggttgtgatt acgactaata acggtgctct tcctaataag attactgaaa agactgacgc     3300

taacggcgtt gcccgcattg cccttacgaa cacaaccgat ggggtcacgg tagttaccgc     3360

agaggtcgag gggcaacgcc aatccgttga cacgcacttc gttaagggta ctatcgcggc     3420

cgataaaagc acgctggccg cggtcgacta taaggatgac gacgacaagc aattggaagt     3480

tcgcctgttg gagagcggtg gtggacttgt gaaacccgag ggaagcctta aactttcgtg     3540

cgttgctagt gggttcacat tttcagacta tttcatgtcc tgggtccgtc aagccccggg     3600

aaaaggactt gaatgggttg cccatattta caccaagagc tataactatg ccacatacta     3660

ttctggaagc gttaaaggtc gttttaccat ttcgcgtgac gacagccgtt ctatggtgta     3720

tttgcagatg aataaccttc gtacagaaga tacggctact tactactgta ctcgcgatgg     3780

atcaggctat cccagtttag atttctgggg acagggtact caggttactg tttcaagcgg     3840

tggaggcggc tctggcggtg gtgggagtgg aggcggtggc agttacgagc tgacgcagcc     3900

accctcggca agtgtaaacg tgggcgaaac ggtgaaaatt acttgttcgg gggatcaact     3960

gcccaaatac ttcgccgatt ggtttcatca acgttccgat cagactattt tacaagtgat     4020

ttatgatgat aacaaacgtc cgtcaggaat cccagagcgt atcagcggat cgagcagcgg     4080

aacaacagca actttgacca tccgcgatgt ccgtgccgaa gacgaggggg actactattg     4140

tttctctgga tacgtggact cagacagcaa gctgtatgtt tttggctcag gaacacaact     4200

gaccgtactg ggcaagggcg agctcaattc gaagcttgaa ggtaagccta tccctaaccc     4260

tctcctcggc ctcgattcta cgcgtaccgg tcatcatcac catcaccatt gagcatgcta     4320

atcagccgtg gaattcgcaa cgtaaaaaaa cccgccccgg cgggtttttt tataccggtc     4380

tcaggaggaa cgattggtaa acccggtgaa cgcatgagaa agcccccgga agatcacctt     4440

ccgggggctt ttttattgcg cggaccaaaa cgaaaaaaga cgctcgaaag cgtctctttt     4500

ctggaatttg gtaccgaggc gtaatgctct gccagtgtta caaccaatta accaattctg     4560

attagaaaaa ctcatcgagc atcaaatgaa actgcaattt attcatatca ggattatcaa     4620

taccatattt ttgaaaaagc cgtttctgta atgaaggaga aaactcaccg aggcagttcc     4680

ataggatggc aagatcctgg tatcggtctg cgattccgac tcgtccaaca tcaatacaac     4740

ctattaattt cccctcgtca aaaataaggt tatcaagtga gaaatcacca tgagtgacga     4800

ctgaatccgg tgagaatggc aaaagcttat gcatttcttt ccagacttgt tcaacaggcc     4860

agccattacg ctcgtcatca aaatcactcg catcaaccaa accgttattc attcgtgatt     4920

gcgcctgagc gagacgaaat acgcgatcgc tgttaaaagg acaattacaa acaggaatcg     4980

aatgcaaccg gcgcaggaac actgccagcg catcaacaat attttcacct gaatcaggat     5040

attcttctaa tacctggaat gctgttttcc cggggatcgc agtggtgagt aaccatgcat     5100

catcaggagt acggataaaa tgcttgatgg tcggaagagg cataaattcc gtcagccagt     5160

ttagtctgac catctcatct gtaacatcat tggcaacgct acctttgcca tgtttcagaa     5220

acaactctgg cgcatcgggc ttcccataca atcgatagat tgtcgcacct gattgcccga     5280

cattatcgcg agcccattta tacccatata aatcagcatc catgttggaa tttaatcgcg     5340

gcctcgagca agacgtttcc cgttgaatat ggctcataac accccttgta ttactgttta     5400

tgtaagcaga cagttttatt gttcatgatg atatattttt atcttgtgca atgtaacatc     5460

agagattttg agacacaacg tggctttgtt gaataaatcg aacttttgct gagttgaagg     5520

atcagatcac gcatcttccc gacaacgcag accgttccgt ggcaaagcaa aagttcaaaa     5580

tcaccaactg gtccacctac aacaaagctc tcatcaaccg tggctccctc actttctggc     5640

tggatgatgg ggcgattcag gcctggtatg agtcagcaac accttcttca cgaggcagac     5700

ctcagcgc                                                              5708


<210> 988
<211> 4282
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="p15A-Kan-ptet-LppOmpA-FLAG-J43scFv-V5-HIS"

<400> 988
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttt      900

aagacccact ttcacattta agttgttttt ctaatccgca tatgatcaat tcaaggccga      960

ataagaaggc tggctctgca ccttggtgat caaataattc gatagcttgt cgtaataatg     1020

gcggcatact atcagtagta ggtgtttccc tttcttcttt agcgacttga tgctcttgat     1080

cttccaatac gcaacctaaa gtaaaatgcc ccacagcgct gagtgcatat aatgcattct     1140

ctagtgaaaa accttgttgg cataaaaagg ctaattgatt ttcgagagtt tcatactgtt     1200

tttctgtagg ccgtgtacct aaatgtactt ttgctccatc gcgatgactt agtaaagcac     1260

atctaaaact tttagcgtta ttacgtaaaa aatcttgcca gctttcccct tctaaagggc     1320

aaaagtgagt atggtgccta tctaacatct caatggctaa ggcgtcgagc aaagcccgct     1380

tattttttac atgccaatac aatgtaggct gctctacacc tagcttctgg gcgagtttac     1440

gggttgttaa accttcgatt ccgacctcat taagcagctc taatgcgctg ttaatcactt     1500

tacttttatc taatctagac atcattaatt cctaattttt gttgacactc tatcattgat     1560

agagttattt taccactccc tatcagtgat agagaaaagt gaaaggaggt aaattatgac     1620

tagtaaagca acaaaacttg tgttaggcgc ggttatactt ggctccaccc tgcttgcagg     1680

ttgctcgtct aacgcgaaga tcgaccaggg tatcaatcct tacgtcgggt ttgaaatggg     1740

atacgattgg ttgggacgta tgccttataa gggaagtgtt gaaaacggcg cttataaggc     1800

gcagggagta cagttaacgg ccaagcttgg gtaccccata acagacgatt tagatattta     1860

tacccgttta ggaggaatgg tttggagagc cgacacgaag tctaatgtat atggtaagaa     1920

ccacgacacg ggagtatccc ccgtctttgc agggggagtg gaatatgcta tcacaccaga     1980

gatcgctacc cgtttggaat atcaatggac gaataatata ggcgacgccc atacgatagg     2040

aacgcggccc gacaacggca tccctggggt cgactataag gatgacgacg acaagcaatt     2100

ggaagttcgc ctgttggaga gcggtggtgg acttgtgaaa cccgagggaa gccttaaact     2160

ttcgtgcgtt gctagtgggt tcacattttc agactatttc atgtcctggg tccgtcaagc     2220

cccgggaaaa ggacttgaat gggttgccca tatttacacc aagagctata actatgccac     2280

atactattct ggaagcgtta aaggtcgttt taccatttcg cgtgacgaca gccgttctat     2340

ggtgtatttg cagatgaata accttcgtac agaagatacg gctacttact actgtactcg     2400

cgatggatca ggctatccca gtttagattt ctggggacag ggtactcagg ttactgtttc     2460

aagcggtgga ggcggctctg gcggtggtgg gagtggaggc ggtggcagtt acgagctgac     2520

gcagccaccc tcggcaagtg taaacgtggg cgaaacggtg aaaattactt gttcggggga     2580

tcaactgccc aaatacttcg ccgattggtt tcatcaacgt tccgatcaga ctattttaca     2640

agtgatttat gatgataaca aacgtccgtc aggaatccca gagcgtatca gcggatcgag     2700

cagcggaaca acagcaactt tgaccatccg cgatgtccgt gccgaagacg agggggacta     2760

ctattgtttc tctggatacg tggactcaga cagcaagctg tatgtttttg gctcaggaac     2820

acaactgacc gtactgggca agggcgagct caattcgaag cttgaaggta agcctatccc     2880

taaccctctc ctcggcctcg attctacgcg taccggtcat catcaccatc accattgagc     2940

atgcgaattc ggtctcagga ggaacgattg gtaaacccgg tgaacgcatg agaaagcccc     3000

cggaagatca ccttccgggg gcttttttat tgcgcggacc aaaacgaaaa aagacgctcg     3060

aaagcgtctc ttttctggaa tttggtaccg aggcgtaatg ctctgccagt gttacaacca     3120

attaaccaat tctgattaga aaaactcatc gagcatcaaa tgaaactgca atttattcat     3180

atcaggatta tcaataccat atttttgaaa aagccgtttc tgtaatgaag gagaaaactc     3240

accgaggcag ttccatagga tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc     3300

aacatcaata caacctatta atttcccctc gtcaaaaata aggttatcaa gtgagaaatc     3360

accatgagtg acgactgaat ccggtgagaa tggcaaaagc ttatgcattt ctttccagac     3420

ttgttcaaca ggccagccat tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt     3480

attcattcgt gattgcgcct gagcgagacg aaatacgcga tcgctgttaa aaggacaatt     3540

acaaacagga atcgaatgca accggcgcag gaacactgcc agcgcatcaa caatattttc     3600

acctgaatca ggatattctt ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt     3660

gagtaaccat gcatcatcag gagtacggat aaaatgcttg atggtcggaa gaggcataaa     3720

ttccgtcagc cagtttagtc tgaccatctc atctgtaaca tcattggcaa cgctaccttt     3780

gccatgtttc agaaacaact ctggcgcatc gggcttccca tacaatcgat agattgtcgc     3840

acctgattgc ccgacattat cgcgagccca tttataccca tataaatcag catccatgtt     3900

ggaatttaat cgcggcctcg agcaagacgt ttcccgttga atatggctca taacacccct     3960

tgtattactg tttatgtaag cagacagttt tattgttcat gatgatatat ttttatcttg     4020

tgcaatgtaa catcagagat tttgagacac aacgtggctt tgttgaataa atcgaacttt     4080

tgctgagttg aaggatcaga tcacgcatct tcccgacaac gcagaccgtt ccgtggcaaa     4140

gcaaaagttc aaaatcacca actggtccac ctacaacaaa gctctcatca accgtggctc     4200

cctcactttc tggctggatg atggggcgat tcaggcctgg tatgagtcag caacaccttc     4260

ttcacgaggc agacctcagc gc                                              4282


<210> 989
<211> 5864
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="p15A-Kan-ptet-IntiminN-FLAG-J43scFv-V5-HIS"

<400> 989
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttt      900

aagacccact ttcacattta agttgttttt ctaatccgca tatgatcaat tcaaggccga      960

ataagaaggc tggctctgca ccttggtgat caaataattc gatagcttgt cgtaataatg     1020

gcggcatact atcagtagta ggtgtttccc tttcttcttt agcgacttga tgctcttgat     1080

cttccaatac gcaacctaaa gtaaaatgcc ccacagcgct gagtgcatat aatgcattct     1140

ctagtgaaaa accttgttgg cataaaaagg ctaattgatt ttcgagagtt tcatactgtt     1200

tttctgtagg ccgtgtacct aaatgtactt ttgctccatc gcgatgactt agtaaagcac     1260

atctaaaact tttagcgtta ttacgtaaaa aatcttgcca gctttcccct tctaaagggc     1320

aaaagtgagt atggtgccta tctaacatct caatggctaa ggcgtcgagc aaagcccgct     1380

tattttttac atgccaatac aatgtaggct gctctacacc tagcttctgg gcgagtttac     1440

gggttgttaa accttcgatt ccgacctcat taagcagctc taatgcgctg ttaatcactt     1500

tacttttatc taatctagac atcattaatt cctaattttt gttgacactc tatcattgat     1560

agagttattt taccactccc tatcagtgat agagaaaagt gaaaggaggt aaattatgac     1620

tagtattacg catggctgtt atacccgtac gcgtcataaa cacaagttga agaaaactct     1680

gatcatgtta tccgctggac ttggactttt tttttacgtg aatcagaact ctttcgctaa     1740

tggggaaaat tattttaaac tgggatcaga cagcaaatta cttacgcatg actcatacca     1800

gaatcgtctg ttttatacgc tgaaaactgg tgaaaccgtt gcagatttaa gtaaaagtca     1860

ggacattaac ctgtcaacta tttggtcact taataaacac ttatattcga gcgaatcgga     1920

aatgatgaaa gctgcaccgg ggcaacaaat catcttgccc ctgaagaaat tgccctttga     1980

atactccgct ttgcccttgc tgggctcggc tcctctggta gccgccggag gcgttgccgg     2040

tcacactaat aagctgacaa aaatgtcacc cgacgtgacg aagagcaaca tgacggatga     2100

taaggcttta aattacgcag ctcagcaagc ggcctcgttg ggaagtcagt tacagagtcg     2160

ttcgttaaat ggtgattatg ctaaggatac cgcattgggt attgccggca accaagcgtc     2220

gagccaactt caggcatggt tgcaacatta cggcactgct gaagtaaatc tgcaatcagg     2280

taataatttt gacggtagtt ccctggattt ccttttacct ttttacgatt cagaaaagat     2340

gttggctttc ggacaggtgg gggcgcgtta catcgattca cgttttaccg ctaacttggg     2400

ggccggtcaa cgcttcttct tacctgccaa tatgttgggc tataatgtat ttatcgacca     2460

ggacttcagt ggtgacaata cacgtctggg aattggtgga gagtattggc gcgattactt     2520

taagtcatct gtaaatggct attttcgcat gagcggttgg catgaaagtt acaacaagaa     2580

agactacgat gagcgccccg cgaacgggtt tgacatccgt tttaatggtt atttgccatc     2640

ttatcccgcc ttgggagcta aattaatcta cgagcaatac tatggagata acgtagcttt     2700

gtttaatagc gacaagttac agtctaatcc aggagcggct acagtgggag ttaattatac     2760

cccaatccca ctggtcacaa tgggaatcga ttatcgccac gggactggta atgaaaacga     2820

tttattatac tccatgcagt ttcgttatca gttcgataag agttggtcgc agcagattga     2880

gcctcaatat gttaacgaat tacgtacctt gtccggcagt cgctacgatc tggtacaacg     2940

caataacaat atcatccttg agtataagaa acaggacatt ctgtctttga acattccaca     3000

tgatattaat ggtaccgagc actcaacaca aaaaattcag ctgattgtga aatcaaagta     3060

tggactggac cgtatcgtgt gggatgatag cgctctgcgc agtcagggtg gacagatcca     3120

gcactcgggt agccagtctg cccaagacta ccaggctatc ctgccagcgt atgtccaagg     3180

gggaagtaac atctacaaag ttacagctcg cgcctattac cgcaacggta attctagtaa     3240

taatgtgcag ttgacaatta cggtgctgtc caatgggcag gtcgtcgatc aggtaggtgt     3300

gacggatttt acagccgata aaacctctgc gaaggcagat aacgcggata ccatcacata     3360

cactgccact gtaaaaaaaa acggtgtcgc gcaggcaaac gttcctgtta gcttcaacat     3420

cgtgtcgggt acagccaccc ttggggccaa ctcggcaaag actgacgcga atggcaaggc     3480

tacagtcacg ttgaaatcct cgacaccagg acaggtcgtt gtgtctgcca agacagcaga     3540

gatgacctcc gcccttaatg catctgctgt tatcttcttc gatcaaacga aggcatctgt     3600

cgactataag gatgacgacg acaagcaatt ggaagttcgc ctgttggaga gcggtggtgg     3660

acttgtgaaa cccgagggaa gccttaaact ttcgtgcgtt gctagtgggt tcacattttc     3720

agactatttc atgtcctggg tccgtcaagc cccgggaaaa ggacttgaat gggttgccca     3780

tatttacacc aagagctata actatgccac atactattct ggaagcgtta aaggtcgttt     3840

taccatttcg cgtgacgaca gccgttctat ggtgtatttg cagatgaata accttcgtac     3900

agaagatacg gctacttact actgtactcg cgatggatca ggctatccca gtttagattt     3960

ctggggacag ggtactcagg ttactgtttc aagcggtgga ggcggctctg gcggtggtgg     4020

gagtggaggc ggtggcagtt acgagctgac gcagccaccc tcggcaagtg taaacgtggg     4080

cgaaacggtg aaaattactt gttcggggga tcaactgccc aaatacttcg ccgattggtt     4140

tcatcaacgt tccgatcaga ctattttaca agtgatttat gatgataaca aacgtccgtc     4200

aggaatccca gagcgtatca gcggatcgag cagcggaaca acagcaactt tgaccatccg     4260

cgatgtccgt gccgaagacg agggggacta ctattgtttc tctggatacg tggactcaga     4320

cagcaagctg tatgtttttg gctcaggaac acaactgacc gtactgggca agggcgagct     4380

caattcgaag cttgaaggta agcctatccc taaccctctc ctcggcctcg attctacgcg     4440

taccggtcat catcaccatc accattgagc atgctaatca gccgtggaat tcgcaacgta     4500

aaaaaacccg ccccggcggg tttttttata ccggtctcag gaggaacgat tggtaaaccc     4560

ggtgaacgca tgagaaagcc cccggaagat caccttccgg gggctttttt attgcgcgga     4620

ccaaaacgaa aaaagacgct cgaaagcgtc tcttttctgg aatttggtac cgaggcgtaa     4680

tgctctgcca gtgttacaac caattaacca attctgatta gaaaaactca tcgagcatca     4740

aatgaaactg caatttattc atatcaggat tatcaatacc atatttttga aaaagccgtt     4800

tctgtaatga aggagaaaac tcaccgaggc agttccatag gatggcaaga tcctggtatc     4860

ggtctgcgat tccgactcgt ccaacatcaa tacaacctat taatttcccc tcgtcaaaaa     4920

taaggttatc aagtgagaaa tcaccatgag tgacgactga atccggtgag aatggcaaaa     4980

gcttatgcat ttctttccag acttgttcaa caggccagcc attacgctcg tcatcaaaat     5040

cactcgcatc aaccaaaccg ttattcattc gtgattgcgc ctgagcgaga cgaaatacgc     5100

gatcgctgtt aaaaggacaa ttacaaacag gaatcgaatg caaccggcgc aggaacactg     5160

ccagcgcatc aacaatattt tcacctgaat caggatattc ttctaatacc tggaatgctg     5220

ttttcccggg gatcgcagtg gtgagtaacc atgcatcatc aggagtacgg ataaaatgct     5280

tgatggtcgg aagaggcata aattccgtca gccagtttag tctgaccatc tcatctgtaa     5340

catcattggc aacgctacct ttgccatgtt tcagaaacaa ctctggcgca tcgggcttcc     5400

catacaatcg atagattgtc gcacctgatt gcccgacatt atcgcgagcc catttatacc     5460

catataaatc agcatccatg ttggaattta atcgcggcct cgagcaagac gtttcccgtt     5520

gaatatggct cataacaccc cttgtattac tgtttatgta agcagacagt tttattgttc     5580

atgatgatat atttttatct tgtgcaatgt aacatcagag attttgagac acaacgtggc     5640

tttgttgaat aaatcgaact tttgctgagt tgaaggatca gatcacgcat cttcccgaca     5700

acgcagaccg ttccgtggca aagcaaaagt tcaaaatcac caactggtcc acctacaaca     5760

aagctctcat caaccgtggc tccctcactt tctggctgga tgatggggcg attcaggcct     5820

ggtatgagtc agcaacacct tcttcacgag gcagacctca gcgc                      5864


<210> 990
<211> 607
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Invasin display tag"

<400> 990
Met Val Phe Gln Pro Ile Ser Glu Phe Leu Leu Ile Arg Asn Ala Gly 
1               5                   10                  15      


Met Ser Met Tyr Phe Asn Lys Ile Ile Ser Phe Asn Ile Ile Ser Arg 
            20                  25                  30          


Ile Val Ile Cys Ile Phe Leu Ile Cys Gly Met Phe Met Ala Gly Ala 
        35                  40                  45              


Ser Glu Lys Tyr Asp Ala Asn Ala Pro Gln Gln Val Gln Pro Tyr Ser 
    50                  55                  60                  


Val Ser Ser Ser Ala Phe Glu Asn Leu His Pro Asn Asn Glu Met Glu 
65                  70                  75                  80  


Ser Ser Ile Asn Pro Phe Ser Ala Ser Asp Thr Glu Arg Asn Ala Ala 
                85                  90                  95      


Ile Ile Asp Arg Ala Asn Lys Glu Gln Glu Thr Glu Ala Val Asn Lys 
            100                 105                 110         


Met Ile Ser Thr Gly Ala Arg Leu Ala Ala Ser Gly Arg Ala Ser Asp 
        115                 120                 125             


Val Ala His Ser Met Val Gly Asp Ala Val Asn Gln Glu Ile Lys Gln 
    130                 135                 140                 


Trp Leu Asn Arg Phe Gly Thr Ala Gln Val Asn Leu Asn Phe Asp Lys 
145                 150                 155                 160 


Asn Phe Ser Leu Lys Glu Ser Ser Leu Asp Trp Leu Ala Pro Trp Tyr 
                165                 170                 175     


Asp Ser Ala Ser Phe Leu Phe Phe Ser Gln Leu Gly Ile Arg Asn Lys 
            180                 185                 190         


Asp Ser Arg Asn Thr Leu Asn Leu Gly Val Gly Ile Arg Thr Leu Glu 
        195                 200                 205             


Asn Gly Trp Leu Tyr Gly Leu Asn Thr Phe Tyr Asp Asn Asp Leu Thr 
    210                 215                 220                 


Gly His Asn His Arg Ile Gly Leu Gly Ala Glu Ala Trp Thr Asp Tyr 
225                 230                 235                 240 


Leu Gln Leu Ala Ala Asn Gly Tyr Phe Arg Leu Asn Gly Trp His Ser 
                245                 250                 255     


Ser Arg Asp Phe Ser Asp Tyr Lys Glu Arg Pro Ala Thr Gly Gly Asp 
            260                 265                 270         


Leu Arg Ala Asn Ala Tyr Leu Pro Ala Leu Pro Gln Leu Gly Gly Lys 
        275                 280                 285             


Leu Met Tyr Glu Gln Tyr Thr Gly Glu Arg Val Ala Leu Phe Gly Lys 
    290                 295                 300                 


Asp Asn Leu Gln Arg Asn Pro Tyr Ala Val Thr Ala Gly Ile Asn Tyr 
305                 310                 315                 320 


Thr Pro Val Pro Leu Leu Thr Val Gly Val Asp Gln Arg Met Gly Lys 
                325                 330                 335     


Ser Ser Lys His Glu Thr Gln Trp Asn Leu Gln Met Asn Tyr Arg Leu 
            340                 345                 350         


Gly Glu Ser Phe Gln Ser Gln Leu Ser Pro Ser Ala Val Ala Gly Thr 
        355                 360                 365             


Arg Leu Leu Ala Glu Ser Arg Tyr Asn Leu Val Asp Arg Asn Asn Asn 
    370                 375                 380                 


Ile Val Leu Glu Tyr Gln Lys Gln Gln Val Val Lys Leu Thr Leu Ser 
385                 390                 395                 400 


Pro Ala Thr Ile Ser Gly Leu Pro Gly Gln Val Tyr Gln Val Asn Ala 
                405                 410                 415     


Gln Val Gln Gly Ala Ser Ala Val Arg Glu Ile Val Trp Ser Asp Ala 
            420                 425                 430         


Glu Leu Ile Ala Ala Gly Gly Thr Leu Thr Pro Leu Ser Thr Thr Gln 
        435                 440                 445             


Phe Asn Leu Val Leu Pro Pro Tyr Lys Arg Thr Ala Gln Val Ser Arg 
    450                 455                 460                 


Val Thr Asp Asp Leu Thr Ala Asn Phe Tyr Ser Leu Ser Ala Leu Ala 
465                 470                 475                 480 


Val Asp His Gln Gly Asn Arg Ser Asn Ser Phe Thr Leu Ser Val Thr 
                485                 490                 495     


Val Gln Gln Pro Gln Leu Thr Leu Thr Ala Ala Val Ile Gly Asp Gly 
            500                 505                 510         


Ala Pro Ala Asn Gly Lys Thr Ala Ile Thr Val Glu Phe Thr Val Ala 
        515                 520                 525             


Asp Phe Glu Gly Lys Pro Leu Ala Gly Gln Glu Val Val Ile Thr Thr 
    530                 535                 540                 


Asn Asn Gly Ala Leu Pro Asn Lys Ile Thr Glu Lys Thr Asp Ala Asn 
545                 550                 555                 560 


Gly Val Ala Arg Ile Ala Leu Thr Asn Thr Thr Asp Gly Val Thr Val 
                565                 570                 575     


Val Thr Ala Glu Val Glu Gly Gln Arg Gln Ser Val Asp Thr His Phe 
            580                 585                 590         


Val Lys Gly Thr Ile Ala Ala Asp Lys Ser Thr Leu Ala Ala Val 
        595                 600                 605         


<210> 991
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="LppOmpA display tag"

<400> 991
Lys Ala Thr Lys Leu Val Leu Gly Ala Val Ile Leu Gly Ser Thr Leu 
1               5                   10                  15      


Leu Ala Gly Cys Ser Ser Asn Ala Lys Ile Asp Gln Gly Ile Asn Pro 
            20                  25                  30          


Tyr Val Gly Phe Glu Met Gly Tyr Asp Trp Leu Gly Arg Met Pro Tyr 
        35                  40                  45              


Lys Gly Ser Val Glu Asn Gly Ala Tyr Lys Ala Gln Gly Val Gln Leu 
    50                  55                  60                  


Thr Ala Lys Leu Gly Tyr Pro Ile Thr Asp Asp Leu Asp Ile Tyr Thr 
65                  70                  75                  80  


Arg Leu Gly Gly Met Val Trp Arg Ala Asp Thr Lys Ser Asn Val Tyr 
                85                  90                  95      


Gly Lys Asn His Asp Thr Gly Val Ser Pro Val Phe Ala Gly Gly Val 
            100                 105                 110         


Glu Tyr Ala Ile Thr Pro Glu Ile Ala Thr Arg Leu Glu Tyr Gln Trp 
        115                 120                 125             


Thr Asn Asn Ile Gly Asp Ala His Thr Ile Gly Thr Arg Pro Asp Asn 
    130                 135                 140                 


Gly Ile Pro Gly 
145             


<210> 992
<211> 658
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="IntiminN display tag"

<400> 992
Ile Thr His Gly Cys Tyr Thr Arg Thr Arg His Lys His Lys Leu Lys 
1               5                   10                  15      


Lys Thr Leu Ile Met Leu Ser Ala Gly Leu Gly Leu Phe Phe Tyr Val 
            20                  25                  30          


Asn Gln Asn Ser Phe Ala Asn Gly Glu Asn Tyr Phe Lys Leu Gly Ser 
        35                  40                  45              


Asp Ser Lys Leu Leu Thr His Asp Ser Tyr Gln Asn Arg Leu Phe Tyr 
    50                  55                  60                  


Thr Leu Lys Thr Gly Glu Thr Val Ala Asp Leu Ser Lys Ser Gln Asp 
65                  70                  75                  80  


Ile Asn Leu Ser Thr Ile Trp Ser Leu Asn Lys His Leu Tyr Ser Ser 
                85                  90                  95      


Glu Ser Glu Met Met Lys Ala Ala Pro Gly Gln Gln Ile Ile Leu Pro 
            100                 105                 110         


Leu Lys Lys Leu Pro Phe Glu Tyr Ser Ala Leu Pro Leu Leu Gly Ser 
        115                 120                 125             


Ala Pro Leu Val Ala Ala Gly Gly Val Ala Gly His Thr Asn Lys Leu 
    130                 135                 140                 


Thr Lys Met Ser Pro Asp Val Thr Lys Ser Asn Met Thr Asp Asp Lys 
145                 150                 155                 160 


Ala Leu Asn Tyr Ala Ala Gln Gln Ala Ala Ser Leu Gly Ser Gln Leu 
                165                 170                 175     


Gln Ser Arg Ser Leu Asn Gly Asp Tyr Ala Lys Asp Thr Ala Leu Gly 
            180                 185                 190         


Ile Ala Gly Asn Gln Ala Ser Ser Gln Leu Gln Ala Trp Leu Gln His 
        195                 200                 205             


Tyr Gly Thr Ala Glu Val Asn Leu Gln Ser Gly Asn Asn Phe Asp Gly 
    210                 215                 220                 


Ser Ser Leu Asp Phe Leu Leu Pro Phe Tyr Asp Ser Glu Lys Met Leu 
225                 230                 235                 240 


Ala Phe Gly Gln Val Gly Ala Arg Tyr Ile Asp Ser Arg Phe Thr Ala 
                245                 250                 255     


Asn Leu Gly Ala Gly Gln Arg Phe Phe Leu Pro Ala Asn Met Leu Gly 
            260                 265                 270         


Tyr Asn Val Phe Ile Asp Gln Asp Phe Ser Gly Asp Asn Thr Arg Leu 
        275                 280                 285             


Gly Ile Gly Gly Glu Tyr Trp Arg Asp Tyr Phe Lys Ser Ser Val Asn 
    290                 295                 300                 


Gly Tyr Phe Arg Met Ser Gly Trp His Glu Ser Tyr Asn Lys Lys Asp 
305                 310                 315                 320 


Tyr Asp Glu Arg Pro Ala Asn Gly Phe Asp Ile Arg Phe Asn Gly Tyr 
                325                 330                 335     


Leu Pro Ser Tyr Pro Ala Leu Gly Ala Lys Leu Ile Tyr Glu Gln Tyr 
            340                 345                 350         


Tyr Gly Asp Asn Val Ala Leu Phe Asn Ser Asp Lys Leu Gln Ser Asn 
        355                 360                 365             


Pro Gly Ala Ala Thr Val Gly Val Asn Tyr Thr Pro Ile Pro Leu Val 
    370                 375                 380                 


Thr Met Gly Ile Asp Tyr Arg His Gly Thr Gly Asn Glu Asn Asp Leu 
385                 390                 395                 400 


Leu Tyr Ser Met Gln Phe Arg Tyr Gln Phe Asp Lys Ser Trp Ser Gln 
                405                 410                 415     


Gln Ile Glu Pro Gln Tyr Val Asn Glu Leu Arg Thr Leu Ser Gly Ser 
            420                 425                 430         


Arg Tyr Asp Leu Val Gln Arg Asn Asn Asn Ile Ile Leu Glu Tyr Lys 
        435                 440                 445             


Lys Gln Asp Ile Leu Ser Leu Asn Ile Pro His Asp Ile Asn Gly Thr 
    450                 455                 460                 


Glu His Ser Thr Gln Lys Ile Gln Leu Ile Val Lys Ser Lys Tyr Gly 
465                 470                 475                 480 


Leu Asp Arg Ile Val Trp Asp Asp Ser Ala Leu Arg Ser Gln Gly Gly 
                485                 490                 495     


Gln Ile Gln His Ser Gly Ser Gln Ser Ala Gln Asp Tyr Gln Ala Ile 
            500                 505                 510         


Leu Pro Ala Tyr Val Gln Gly Gly Ser Asn Ile Tyr Lys Val Thr Ala 
        515                 520                 525             


Arg Ala Tyr Tyr Arg Asn Gly Asn Ser Ser Asn Asn Val Gln Leu Thr 
    530                 535                 540                 


Ile Thr Val Leu Ser Asn Gly Gln Val Val Asp Gln Val Gly Val Thr 
545                 550                 555                 560 


Asp Phe Thr Ala Asp Lys Thr Ser Ala Lys Ala Asp Asn Ala Asp Thr 
                565                 570                 575     


Ile Thr Tyr Thr Ala Thr Val Lys Lys Asn Gly Val Ala Gln Ala Asn 
            580                 585                 590         


Val Pro Val Ser Phe Asn Ile Val Ser Gly Thr Ala Thr Leu Gly Ala 
        595                 600                 605             


Asn Ser Ala Lys Thr Asp Ala Asn Gly Lys Ala Thr Val Thr Leu Lys 
    610                 615                 620                 


Ser Ser Thr Pro Gly Gln Val Val Val Ser Ala Lys Thr Ala Glu Met 
625                 630                 635                 640 


Thr Ser Ala Leu Asn Ala Ser Ala Val Ile Phe Phe Asp Gln Thr Lys 
                645                 650                 655     


Ala Ser 
        


<210> 993
<211> 5121
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="pUC-ptet-B6H12antihCD47scFv-V5-HIS"

<400> 993
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagctat      240

ttaggtgaca ctatagaata ctcaagctat gcatcaagct tggtaccgag ctcggatcca      300

ctagtaacgg ccgccagtgt gctggaattc gcccttttaa gacccacttt cacatttaag      360

ttgtttttct aatccgcaga tgatcaattc aaggccgaat aagaaggctg gctctgcacc      420

ttggtgatca aataattcga tagcttgtcg taataatggc ggcatactat cagtagtagg      480

tgtttccctt tcttctttag cgacttgatg ctcttgatct tccaatacgc aacctaaagt      540

aaaatgcccc acagcgctga gtgcatataa tgcattctct agtgaaaaac cttgttggca      600

taaaaaggct aattgatttt cgagagtttc atactgtttt tctgtaggcc gtgtacctaa      660

atgtactttt gctccatcgc gatgacttag taaagcacat ctaaaacttt tagcgttatt      720

acgtaaaaaa tcttgccagc tttccccttc taaagggcaa aagtgagtat ggtgcctatc      780

taacatctca atggctaagg cgtcgagcaa agcccgctta ttttttacat gccaatacaa      840

tgtaggctgc tctacaccta gcttctgggc gagtttacgg gttgttaaac cttcgattcc      900

gacctcatta agcagctcta atgcgctgtt aatcacttta cttttatcta atctagacat      960

cattaattcc taatttttgt tgacactcta tcattgatag agttatttta ccactcccta     1020

tcagtgatag agaaaagtga aaggaggtaa attcatatga ctagtcaatt gggtggtagc     1080

gaggtccagc tggtggaatc tggcggagac ttagtaaagc cgggaggttc gttgaagttg     1140

agttgcgctg ctagtgggtt tacgtttagc ggctatggta tgtcatgggt ccgccaaaca     1200

cccgataaac gtttagagtg ggtcgccacg attacgagtg gaggcaccta cacctattat     1260

ccggattctg tcaaaggccg ctttactatt tctcgtgata atgcaaagaa caccttatat     1320

ttacagatcg actccttgaa gtctgaggat accgcaattt atttctgtgc ccgttcgtta     1380

gccggtaatg ctatggatta ttgggggcaa ggcacatctg tcacagtctc atccggagga     1440

ggcggatcag gtggtggcgg ttctggcggc ggcggatctg acattgtgat gacacaatca     1500

cctgcgacac tttcggttac tccaggagac cgcgttagct tgtcgtgtcg cgcctctcaa     1560

accatcagtg actacttaca ttggtaccaa cagaaatccc atgaatcgcc acgcttactt     1620

attaagtttg cgtcccaatc aattagtggt attccgtcgc gctttagtgg tagcggttct     1680

ggttctgatt tcacattgtc aatcaacagc gtggagccgg aggatgttgg tgtttactac     1740

tgccaaaacg gtcacggctt tccacgtaca ttcggagggg gaacgaagtt ggaaattaaa     1800

ggcagcggcg agctcggtgg cagtggtaag cctatcccta accctctcct cggcctcgat     1860

tctacgggat ccggtcatca tcaccatcac cattgagcat gctaatcagc cgtggaattc     1920

gaattcggtc tcaggaggaa gggcgaattc tgcagatatc catcacactg gcggccgctc     1980

gagcatgcat ctagagggcc caattcgccc tatagtgagt cgtattacaa ttcactggcc     2040

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca     2100

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc     2160

caacagttgc gcagcctata cgtacggcag tttaaggttt acacctataa aagagagagc     2220

cgttatcgtc tgtttgtgga tgtacagagt gatattattg acacgccggg gcgacggatg     2280

gtgatccccc tggccagtgc acgtctgctg tcagataaag tctcccgtga actttacccg     2340

gtggtgcata tcggggatga aagctggcgc atgatgacca ccgatatggc cagtgtgccg     2400

gtctccgtta tcggggaaga agtggctgat ctcagccacc gcgaaaatga catcaaaaac     2460

gccattaacc tgatgttctg gggaatataa atgtcaggca tgagattatc aaaaaggatc     2520

ttcacctaga tccttttcac gtagaaagcc agtccgcaga aacggtgctg accccggatg     2580

aatgtcagct actgggctat ctggacaagg gaaaacgcaa gcgcaaagag aaagcaggta     2640

gcttgcagtg ggcttacatg gcgatagcta gactgggcgg ttttatggac agcaagcgaa     2700

ccggaattgc cagctggggc gccctctggt aaggttggga agccctgcaa agtaaactgg     2760

atggctttct cgccgccaag gatctgatgg cgcaggggat caagctctga tcaagagaca     2820

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     2880

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     2940

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     3000

ggtgccctga atgaactgca agacgaggca gcgcggctat cgtggctggc cacgacgggc     3060

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     3120

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     3180

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     3240

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     3300

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     3360

aaggcgagca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     3420

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     3480

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     3540

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     3600

gccttctatc gccttcttga cgagttcttc tgaattatta acgcttacaa tttcctgatg     3660

cggtattttc tccttacgca tctgtgcggt atttcacacc gcatacaggt ggcacttttc     3720

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     3780

cgctcatgag acaataaccc tgataaatgc ttcaataata gcacgtgagg agggccacca     3840

tggccaagtt gaccagtgcc gttccggtgc tcaccgcgcg cgacgtcgcc ggagcggtcg     3900

agttctggac cgaccggctc gggttctccc gggacttcgt ggaggacgac ttcgccggtg     3960

tggtccggga cgacgtgacc ctgttcatca gcgcggtcca ggaccaggtg gtgccggaca     4020

acaccctggc ctgggtgtgg gtgcgcggcc tggacgagct gtacgccgag tggtcggagg     4080

tcgtgtccac gaacttccgg gacgcctccg ggccggccat gaccgagatc ggcgagcagc     4140

cgtgggggcg ggagttcgcc ctgcgcgacc cggccggcaa ctgcgtgcac ttcgtggccg     4200

aggagcagga ctgacacgtg ctaaaacttc atttttaatt taaaaggatc taggtgaaga     4260

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     4320

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     4380

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     4440

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc     4500

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     4560

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     4620

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     4680

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     4740

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     4800

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     4860

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     4920

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctgggctttt     4980

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     5040

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt     5100

cagtgagcga ggaagcggaa g                                               5121


<210> 994
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="B6H12-anti-CD47-scFv polypeptide sequence"

<400> 994
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Ile Asp Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Thr Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser 
                165                 170                 175     


Pro Arg Leu Leu Ile Lys Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile 
        195                 200                 205             


Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly 
    210                 215                 220                 


His Gly Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


<210> 995
<211> 5133
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="pUC-ptet-5F9antihCD47scFv-V5-HIS"

<400> 995
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagctat      240

ttaggtgaca ctatagaata ctcaagctat gcatcaagct tggtaccgag ctcggatcca      300

ctagtaacgg ccgccagtgt gctggaattc gcccttttaa gacccacttt cacatttaag      360

ttgtttttct aatccgcaga tgatcaattc aaggccgaat aagaaggctg gctctgcacc      420

ttggtgatca aataattcga tagcttgtcg taataatggc ggcatactat cagtagtagg      480

tgtttccctt tcttctttag cgacttgatg ctcttgatct tccaatacgc aacctaaagt      540

aaaatgcccc acagcgctga gtgcatataa tgcattctct agtgaaaaac cttgttggca      600

taaaaaggct aattgatttt cgagagtttc atactgtttt tctgtaggcc gtgtacctaa      660

atgtactttt gctccatcgc gatgacttag taaagcacat ctaaaacttt tagcgttatt      720

acgtaaaaaa tcttgccagc tttccccttc taaagggcaa aagtgagtat ggtgcctatc      780

taacatctca atggctaagg cgtcgagcaa agcccgctta ttttttacat gccaatacaa      840

tgtaggctgc tctacaccta gcttctgggc gagtttacgg gttgttaaac cttcgattcc      900

gacctcatta agcagctcta atgcgctgtt aatcacttta cttttatcta atctagacat      960

cattaattcc taatttttgt tgacactcta tcattgatag agttatttta ccactcccta     1020

tcagtgatag agaaaagtga aaggaggtaa attcatatga ctagtcaatt gggtggtagc     1080

caggtgcagc ttgtgcagag tggcgctgaa gtgaagaaac cgggcgcatc agtgaaagtg     1140

agctgcaaag caagcggtta taccttcacg aactataaca tgcactgggt acgtcaagca     1200

cccggccagc gtcttgagtg gatgggcacc atttatcctg gaaacgacga cacatcctac     1260

aaccaaaagt ttaaggaccg cgtaactatc actgctgaca cttcagcttc cacagcatat     1320

atggagctta gtagcctgcg tagtgaagac acagcggtct actactgcgc acgtggaggg     1380

tatcgtgcga tggactactg ggggcagggc acacttgtga ctgtttcatc tggcggtgga     1440

ggctctggag gggggggtag cggggggggc ggtagcgata tcgtaatgac tcagtcccca     1500

ctttccttac ccgtcacacc gggcgaacct gcatctatta gctgtcgttc gtcgcaaagc     1560

attgtttact cgaatgggaa tacgtacttg gggtggtatc ttcaaaaacc agggcagtcc     1620

cctcagttgt tgatctacaa ggtgtccaac cgctttagtg gggtgcctga tcgtttctct     1680

ggcagtggta gtggtaccga cttcacgctt aaaatttccc gtgtcgaagc agaagacgtt     1740

ggcgtatatt actgcttcca aggcagtcat gtgccataca cgttcgggca aggcaccaaa     1800

cttgagatca aaggcagcgg cgagctcggt ggcagtggta agcctatccc taaccctctc     1860

ctcggcctcg attctacggg atccggtcat catcaccatc accattgagc atgctaatca     1920

gccgtggaat tcgaattcgg tctcaggagg aagggcgaat tctgcagata tccatcacac     1980

tggcggccgc tcgagcatgc atctagaggg cccaattcgc cctatagtga gtcgtattac     2040

aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt     2100

aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc     2160

gatcgccctt cccaacagtt gcgcagccta tacgtacggc agtttaaggt ttacacctat     2220

aaaagagaga gccgttatcg tctgtttgtg gatgtacaga gtgatattat tgacacgccg     2280

gggcgacgga tggtgatccc cctggccagt gcacgtctgc tgtcagataa agtctcccgt     2340

gaactttacc cggtggtgca tatcggggat gaaagctggc gcatgatgac caccgatatg     2400

gccagtgtgc cggtctccgt tatcggggaa gaagtggctg atctcagcca ccgcgaaaat     2460

gacatcaaaa acgccattaa cctgatgttc tggggaatat aaatgtcagg catgagatta     2520

tcaaaaagga tcttcaccta gatccttttc acgtagaaag ccagtccgca gaaacggtgc     2580

tgaccccgga tgaatgtcag ctactgggct atctggacaa gggaaaacgc aagcgcaaag     2640

agaaagcagg tagcttgcag tgggcttaca tggcgatagc tagactgggc ggttttatgg     2700

acagcaagcg aaccggaatt gccagctggg gcgccctctg gtaaggttgg gaagccctgc     2760

aaagtaaact ggatggcttt ctcgccgcca aggatctgat ggcgcagggg atcaagctct     2820

gatcaagaga caggatgagg atcgtttcgc atgattgaac aagatggatt gcacgcaggt     2880

tctccggccg cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc     2940

tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag     3000

accgacctgt ccggtgccct gaatgaactg caagacgagg cagcgcggct atcgtggctg     3060

gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac     3120

tggctgctat tgggcgaagt gccggggcag gatctcctgt catctcacct tgctcctgcc     3180

gagaaagtat ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc     3240

tgcccattcg accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc     3300

ggtcttgtcg atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg     3360

ttcgccaggc tcaaggcgag catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat     3420

gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt ctggattcat cgactgtggc     3480

cggctgggtg tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa     3540

gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat     3600

tcgcagcgca tcgccttcta tcgccttctt gacgagttct tctgaattat taacgcttac     3660

aatttcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatacag     3720

gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt     3780

caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tagcacgtga     3840

ggagggccac catggccaag ttgaccagtg ccgttccggt gctcaccgcg cgcgacgtcg     3900

ccggagcggt cgagttctgg accgaccggc tcgggttctc ccgggacttc gtggaggacg     3960

acttcgccgg tgtggtccgg gacgacgtga ccctgttcat cagcgcggtc caggaccagg     4020

tggtgccgga caacaccctg gcctgggtgt gggtgcgcgg cctggacgag ctgtacgccg     4080

agtggtcgga ggtcgtgtcc acgaacttcc gggacgcctc cgggccggcc atgaccgaga     4140

tcggcgagca gccgtggggg cgggagttcg ccctgcgcga cccggccggc aactgcgtgc     4200

acttcgtggc cgaggagcag gactgacacg tgctaaaact tcatttttaa tttaaaagga     4260

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     4320

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     4380

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     4440

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     4500

caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     4560

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     4620

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     4680

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     4740

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     4800

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     4860

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     4920

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     4980

tcctgggctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg     5040

tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg     5100

agcgcagcga gtcagtgagc gaggaagcgg aag                                  5133


<210> 996
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="5F9-anti-CD47-scFv polypeptide sequence"

<400> 996
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asn Asp Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
    130                 135                 140                 


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 


Ile Val Tyr Ser Asn Gly Asn Thr Tyr Leu Gly Trp Tyr Leu Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210> 997
<211> 2555
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Biosafety Plasmid System Component  dap A"

<400> 997
actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata       60

catatttgaa tgtatttaga aaaataaaca aataggggaa ttaaaaaaaa gcccgctcat      120

taggcgggct actacctagg ccgcggccgc gcgaattcga gctcggtacc cggggatcct      180

ctagagtcga cctgcaggca tgcaagcttg cggccgcgtc gtgactggga aaaccctggc      240

gactagtctt ggactcctgt tgatagatcc agtaatgacc tcagaactcc atctggattt      300

gttcagaacg ctcggttgcc gccgggcgtt ttttattggt gagaatccag gggtccccaa      360

taattacgat ttaaatcaca gcaaacacca cgtcggccct atcagctgcg tgctttctat      420

gagtcgttgc tgcataactt gacaattaac atccggctcg tagggtttgt ggagggccca      480

agttcactta aaaaggagat caacaatgaa agcaattttc gtactgaaac atcttaatca      540

tgctggggag ggtttctaat gttcacggga agtattgtcg cgattgttac tccgatggat      600

gaaaaaggta atgtctgtcg ggctagcttg aaaaaactga ttgattatca tgtcgccagc      660

ggtacttcgg cgatcgtttc tgttggcacc actggcgagt ccgctacctt aaatcatgac      720

gaacatgctg atgtggtgat gatgacgctg gatctggctg atgggcgcat tccggtaatt      780

gccgggaccg gcgctaacgc tactgcggaa gccattagcc tgacgcagcg cttcaatgac      840

agtggtatcg tcggctgcct gacggtaacc ccttactaca atcgtccgtc gcaagaaggt      900

ttgtatcagc atttcaaagc catcgctgag catactgacc tgccgcaaat tctgtataat      960

gtgccgtccc gtactggctg cgatctgctc ccggaaacgg tgggccgtct ggcgaaagta     1020

aaaaatatta tcggaatcaa agaggcaaca gggaacttaa cgcgtgtaaa ccagatcaaa     1080

gagctggttt cagatgattt tgttctgctg agcggcgatg atgcgagcgc gctggacttc     1140

atgcaattgg gcggtcatgg ggttatttcc gttacggcta acgtcgcagc gcgtgatatg     1200

gcccagatgt gcaaactggc agcagaaggg cattttgccg aggcacgcgt tattaatcag     1260

cgtctgatgc cattacacaa caaactattt gtcgaaccca atccaatccc ggtgaaatgg     1320

gcatgtaagg aactgggtct tgtggcgacc gatacgctgc gcctgccaat gacaccaatc     1380

accgacagtg gccgtgagac ggtcagagcg gcgcttaaac atgccggttt gctgtaagac     1440

ttttgtcagg ttcctactgt gacgactacc accgatagac tggagtgttg ctgcgaaaaa     1500

accccgccga agcggggttt tttgcgagaa gtcaccacga ttgtgcttta cacggagtag     1560

tcggcagttc cttaagtcag aatagtggac aggcggccaa gaacttcgtt catgatagtc     1620

tccggaaccc gttcgagtcg ttttccgccc cgtgctttca tatcaattgt ccggggttga     1680

tcgcaacgta caacacctgt ggtacgtatg ccaacaccat ccaacgacac cgcaaagccg     1740

gcagtgcggg caaaattgcc tccgctggtt acgggcacaa caacaggcag gcgggtcacg     1800

cgattaaagg ccgccggtgt gacaatcagc accggccgcg ttccctgctg ctcatgacct     1860

gcggtaggat caagcgagac aagccagatt tcccctcttt ccatctagta taactattgt     1920

ttctctagta acatttattg tacaacacga gcccattttt gtcaaataaa ttttaaatta     1980

tatcaacgtt aataagacgt tgtcaataaa attattttga caaaattggc cggccggcgc     2040

gccgatctga agatcagcag ttcaacctgt tgatagtacg tactaagctc tcatgtttca     2100

cgtactaagc tctcatgttt aacgtactaa gctctcatgt ttaacgaact aaaccctcat     2160

ggctaacgta ctaagctctc atggctaacg tactaagctc tcatgtttca cgtactaagc     2220

tctcatgttt gaacaataaa attaatataa atcagcaact taaatagcct ctaaggtttt     2280

aagttttata agaaaaaaaa gaatatataa ggcttttaaa gcctttaagg tttaacggtt     2340

gtggacaaca agccagggat gtaacgcact gagaagccct tagagcctct caaagcaatt     2400

ttgagtgaca caggaacact taacggctga catggggcgc gcccagctgt ctagggcggc     2460

ggatttgtcc tactcaggag agcgttcacc gacaaacaac agataaaacg aaaggcccag     2520

tctttcgact gagcctttcg ttttatttga tgcct                                2555


<210> 998
<211> 2472
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Biosafety Plasmid System Component  ThyA"

<400> 998
actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata       60

catatttgaa tgtatttaga aaaataaaca aataggggaa ttaaaaaaaa gcccgctcat      120

taggcgggct actacctagg ccgcggccgc gcgaattcga gctcggtacc cggggatcct      180

ctagagtcga cctgcaggca tgcaagcttg cggccgcgtc gtgactggga aaaccctggc      240

gactagtctt ggactcctgt tgatagatcc agtaatgacc tcagaactcc atctggattt      300

gttcagaacg ctcggttgcc gccgggcgtt ttttattggt gagaatccag gggtccccaa      360

taattacgat ttaaatcaca gcaaacacca cgtcggccct atcagctgcg tgctttctat      420

gagtcgttgc tgcataactt gacaattaat catccggctc gtagggtttg tggagggccc      480

aagttcactt aaaaaggaga tcaacaatga aagcaatttt cgtactgaaa catcttaatc      540

atgctgggga gggtttctaa tgaaacagta tttagaactg atgcaaaaag tgctcgacga      600

aggcacacag aaaaacgacc gtaccggaac cggaacgctt tccatttttg gtcatcagat      660

gcgttttaac ctgcaagatg gattcccgct ggtgacaact aaacgttgcc acctgcgttc      720

catcatccat gaactgctgt ggtttcttca gggcgacact aacattgctt atctacacga      780

aaacaatgtc accatctggg acgaatgggc cgatgaaaac ggcgacctcg ggccagtgta      840

tggtaaacag tggcgtgcct ggccaacgcc agatggtcgt catattgacc agatcactac      900

ggtactgaac cagctgaaaa acgacccgga ttcgcgccgc attattgttt cagcgtggaa      960

cgtaggcgaa ctggataaaa tggcgctggc accgtgccat gcattcttcc agttctatgt     1020

ggcagacggc aaactctctt gccagcttta tcagcgctcc tgtgacgtct tcctcggcct     1080

gccgttcaac attgccagct acgcgttatt ggtgcatatg atggcgcagc agtgcgatct     1140

ggaagtgggt gattttgtct ggaccggtgg cgacacgcat ctgtacagca accatatgga     1200

tcaaactcat ctgcaattaa gccgcgaacc gcgtccgctg ccgaagttga ttatcaaacg     1260

taaacccgaa tccatcttcg actaccgttt cgaagacttt gagattgaag gctacgatcc     1320

gcatccgggc attaaagcgc cggtggctat ctaagacttt tgtcaggttc ctactgtgac     1380

gactaccacc gatagactgg agtgttgctg cgaaaaaacc ccgccgaagc ggggtttttt     1440

gcgagaagtc accacgattg tgctttacac ggagtagtcg gcagttcctt aagtcagaat     1500

agtggacagg cggccaagaa cttcgttcat gatagtctcc ggaacccgtt cgagtcgttt     1560

tccgccccgt gctttcatat caattgtccg gggttgatcg caacgtacaa cacctgtggt     1620

acgtatgcca acaccatcca acgacaccgc aaagccggca gtgcgggcaa aattgcctcc     1680

gctggttacg ggcacaacaa caggcaggcg ggtcacgcga ttaaaggccg ccggtgtgac     1740

aatcagcacc ggccgcgttc cctgctgctc atgacctgcg gtaggatcaa gcgagacaag     1800

ccagatttcc cctctttcca tctagtataa ctattgtttc tctagtaaca tttattgtac     1860

aacacgagcc catttttgtc aaataaattt taaattatat caacgttaat aagacgttgt     1920

caataaaatt attttgacaa aattggccgg ccggcgcgcc gatctgaaga tcagcagttc     1980

aacctgttga tagtacgtac taagctctca tgtttcacgt actaagctct catgtttaac     2040

gtactaagct ctcatgttta acgaactaaa ccctcatggc taacgtacta agctctcatg     2100

gctaacgtac taagctctca tgtttcacgt actaagctct catgtttgaa caataaaatt     2160

aatataaatc agcaacttaa atagcctcta aggttttaag ttttataaga aaaaaaagaa     2220

tatataaggc ttttaaagcc tttaaggttt aacggttgtg gacaacaagc cagggatgta     2280

acgcactgag aagcccttag agcctctcaa agcaattttg agtgacacag gaacacttaa     2340

cggctgacat ggggcgcgcc cagctgtcta gggcggcgga tttgtcctac tcaggagagc     2400

gttcaccgac aaacaacaga taaaacgaaa ggcccagtct ttcgactgag cctttcgttt     2460

tatttgatgc ct                                                         2472


<210> 999
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Kid toxin (reverse orientation)"

<400> 999
ttaagtcaga atagtggaca ggcggccaag aacttcgttc atgatagtct ccggaacccg       60

ttcgagtcgt tttccgcccc gtgctttcat atcaattgtc cggggttgat cgcaacgtac      120

aacacctgtg gtacgtatgc caacaccatc caacgacacc gcaaagccgg cagtgcgggc      180

aaaattgcct ccgctggtta cgggcacaac aacaggcagg cgggtcacgc gattaaaggc      240

cgccggtgtg acaatcagca ccggccgcgt tccctgctgc tcatgacctg cggtaggatc      300

aagcgagaca agccagattt cccctctttc cat                                   333


<210> 1000
<211> 879
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="dapA"

<400> 1000
atgttcacgg gaagtattgt cgcgattgtt actccgatgg atgaaaaagg taatgtctgt       60

cgggctagct tgaaaaaact gattgattat catgtcgcca gcggtacttc ggcgatcgtt      120

tctgttggca ccactggcga gtccgctacc ttaaatcatg acgaacatgc tgatgtggtg      180

atgatgacgc tggatctggc tgatgggcgc attccggtaa ttgccgggac cggcgctaac      240

gctactgcgg aagccattag cctgacgcag cgcttcaatg acagtggtat cgtcggctgc      300

ctgacggtaa ccccttacta caatcgtccg tcgcaagaag gtttgtatca gcatttcaaa      360

gccatcgctg agcatactga cctgccgcaa attctgtata atgtgccgtc ccgtactggc      420

tgcgatctgc tcccggaaac ggtgggccgt ctggcgaaag taaaaaatat tatcggaatc      480

aaagaggcaa cagggaactt aacgcgtgta aaccagatca aagagctggt ttcagatgat      540

tttgttctgc tgagcggcga tgatgcgagc gcgctggact tcatgcaatt gggcggtcat      600

ggggttattt ccgttacggc taacgtcgca gcgcgtgata tggcccagat gtgcaaactg      660

gcagcagaag ggcattttgc cgaggcacgc gttattaatc agcgtctgat gccattacac      720

aacaaactat ttgtcgaacc caatccaatc ccggtgaaat gggcatgtaa ggaactgggt      780

cttgtggcga ccgatacgct gcgcctgcca atgacaccaa tcaccgacag tggccgtgag      840

acggtcagag cggcgcttaa acatgccggt ttgctgtaa                             879


<210> 1001
<211> 795
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="thyA"

<400> 1001
atgaaacagt atttagaact gatgcaaaaa gtgctcgacg aaggcacaca gaaaaacgac       60

cgtaccggaa ccggaacgct ttccattttt ggtcatcaga tgcgttttaa cctgcaagat      120

ggattcccgc tggtgacaac taaacgttgc cacctgcgtt ccatcatcca tgaactgctg      180

tggtttcttc agggcgacac taacattgct tatctacacg aaaacaatgt caccatctgg      240

gacgaatggg ccgatgaaaa cggcgacctc gggccagtgt atggtaaaca gtggcgtgcc      300

tggccaacgc cagatggtcg tcatattgac cagatcacta cggtactgaa ccagctgaaa      360

aacgacccgg attcgcgccg cattattgtt tcagcgtgga acgtaggcga actggataaa      420

atggcgctgg caccgtgcca tgcattcttc cagttctatg tggcagacgg caaactctct      480

tgccagcttt atcagcgctc ctgtgacgtc ttcctcggcc tgccgttcaa cattgccagc      540

tacgcgttat tggtgcatat gatggcgcag cagtgcgatc tggaagtggg tgattttgtc      600

tggaccggtg gcgacacgca tctgtacagc aaccatatgg atcaaactca tctgcaatta      660

agccgcgaac cgcgtccgct gccgaagttg attatcaaac gtaaacccga atccatcttc      720

gactaccgtt tcgaagactt tgagattgaa ggctacgatc cgcatccggg cattaaagcg      780

ccggtggcta tctaa                                                       795


<210> 1002
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Kid toxin polypeptide"

<400> 1002
Met Glu Arg Gly Glu Ile Trp Leu Val Ser Leu Asp Pro Thr Ala Gly 
1               5                   10                  15      


His Glu Gln Gln Gly Thr Arg Pro Val Leu Ile Val Thr Pro Ala Ala 
            20                  25                  30          


Phe Asn Arg Val Thr Arg Leu Pro Val Val Val Pro Val Thr Ser Gly 
        35                  40                  45              


Gly Asn Phe Ala Arg Thr Ala Gly Phe Ala Val Ser Leu Asp Gly Val 
    50                  55                  60                  


Gly Ile Arg Thr Thr Gly Val Val Arg Cys Asp Gln Pro Arg Thr Ile 
65                  70                  75                  80  


Asp Met Lys Ala Arg Gly Gly Lys Arg Leu Glu Arg Val Pro Glu Thr 
                85                  90                  95      


Ile Met Asn Glu Val Leu Gly Arg Leu Ser Thr Ile Leu Thr 
            100                 105                 110 


<210> 1003
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="dapA polypeptide"

<400> 1003
Met Phe Thr Gly Ser Ile Val Ala Ile Val Thr Pro Met Asp Glu Lys 
1               5                   10                  15      


Gly Asn Val Cys Arg Ala Ser Leu Lys Lys Leu Ile Asp Tyr His Val 
            20                  25                  30          


Ala Ser Gly Thr Ser Ala Ile Val Ser Val Gly Thr Thr Gly Glu Ser 
        35                  40                  45              


Ala Thr Leu Asn His Asp Glu His Ala Asp Val Val Met Met Thr Leu 
    50                  55                  60                  


Asp Leu Ala Asp Gly Arg Ile Pro Val Ile Ala Gly Thr Gly Ala Asn 
65                  70                  75                  80  


Ala Thr Ala Glu Ala Ile Ser Leu Thr Gln Arg Phe Asn Asp Ser Gly 
                85                  90                  95      


Ile Val Gly Cys Leu Thr Val Thr Pro Tyr Tyr Asn Arg Pro Ser Gln 
            100                 105                 110         


Glu Gly Leu Tyr Gln His Phe Lys Ala Ile Ala Glu His Thr Asp Leu 
        115                 120                 125             


Pro Gln Ile Leu Tyr Asn Val Pro Ser Arg Thr Gly Cys Asp Leu Leu 
    130                 135                 140                 


Pro Glu Thr Val Gly Arg Leu Ala Lys Val Lys Asn Ile Ile Gly Ile 
145                 150                 155                 160 


Lys Glu Ala Thr Gly Asn Leu Thr Arg Val Asn Gln Ile Lys Glu Leu 
                165                 170                 175     


Val Ser Asp Asp Phe Val Leu Leu Ser Gly Asp Asp Ala Ser Ala Leu 
            180                 185                 190         


Asp Phe Met Gln Leu Gly Gly His Gly Val Ile Ser Val Thr Ala Asn 
        195                 200                 205             


Val Ala Ala Arg Asp Met Ala Gln Met Cys Lys Leu Ala Ala Glu Gly 
    210                 215                 220                 


His Phe Ala Glu Ala Arg Val Ile Asn Gln Arg Leu Met Pro Leu His 
225                 230                 235                 240 


Asn Lys Leu Phe Val Glu Pro Asn Pro Ile Pro Val Lys Trp Ala Cys 
                245                 250                 255     


Lys Glu Leu Gly Leu Val Ala Thr Asp Thr Leu Arg Leu Pro Met Thr 
            260                 265                 270         


Pro Ile Thr Asp Ser Gly Arg Glu Thr Val Arg Ala Ala Leu Lys His 
        275                 280                 285             


Ala Gly Leu Leu 
    290         


<210> 1004
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="ThyA polypeptide"

<400> 1004
Met Lys Gln Tyr Leu Glu Leu Met Gln Lys Val Leu Asp Glu Gly Thr 
1               5                   10                  15      


Gln Lys Asn Asp Arg Thr Gly Thr Gly Thr Leu Ser Ile Phe Gly His 
            20                  25                  30          


Gln Met Arg Phe Asn Leu Gln Asp Gly Phe Pro Leu Val Thr Thr Lys 
        35                  40                  45              


Arg Cys His Leu Arg Ser Ile Ile His Glu Leu Leu Trp Phe Leu Gln 
    50                  55                  60                  


Gly Asp Thr Asn Ile Ala Tyr Leu His Glu Asn Asn Val Thr Ile Trp 
65                  70                  75                  80  


Asp Glu Trp Ala Asp Glu Asn Gly Asp Leu Gly Pro Val Tyr Gly Lys 
                85                  90                  95      


Gln Trp Arg Ala Trp Pro Thr Pro Asp Gly Arg His Ile Asp Gln Ile 
            100                 105                 110         


Thr Thr Val Leu Asn Gln Leu Lys Asn Asp Pro Asp Ser Arg Arg Ile 
        115                 120                 125             


Ile Val Ser Ala Trp Asn Val Gly Glu Leu Asp Lys Met Ala Leu Ala 
    130                 135                 140                 


Pro Cys His Ala Phe Phe Gln Phe Tyr Val Ala Asp Gly Lys Leu Ser 
145                 150                 155                 160 


Cys Gln Leu Tyr Gln Arg Ser Cys Asp Val Phe Leu Gly Leu Pro Phe 
                165                 170                 175     


Asn Ile Ala Ser Tyr Ala Leu Leu Val His Met Met Ala Gln Gln Cys 
            180                 185                 190         


Asp Leu Glu Val Gly Asp Phe Val Trp Thr Gly Gly Asp Thr His Leu 
        195                 200                 205             


Tyr Ser Asn His Met Asp Gln Thr His Leu Gln Leu Ser Arg Glu Pro 
    210                 215                 220                 


Arg Pro Leu Pro Lys Leu Ile Ile Lys Arg Lys Pro Glu Ser Ile Phe 
225                 230                 235                 240 


Asp Tyr Arg Phe Glu Asp Phe Glu Ile Glu Gly Tyr Asp Pro His Pro 
                245                 250                 255     


Gly Ile Lys Ala Pro Val Ala Ile 
            260                 


<210> 1005
<211> 1490
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Biosafety Chromosomal Construct -  low copy Rep (Pi)
      and Kis antitoxin (as shown in Fig. 76C)"

<400> 1005
ttgacggcta gctcagtcct aggtacagtg ctagcggatc tgctggaaca ggtggtgaga       60

ctcaaggtca tgatggacgt gaacaaaaaa acgaaaattc gccaccgaaa cgagctaaat      120

cacaccctgg ctcaacttcc tttgcccgca aagcgagtga tgtatatggc gcttgctccc      180

attgatagca aagaacctct tgaacgaggg cgagttttca aaattagggc tgaagacctt      240

gcagcgctcg ccaaaatcac cccatcgctt gcttatcgac aattaaaaga gggtggtaaa      300

ttacttggtg ccagcaaaat ttcgctaaga ggggatgata tcattgcttt agctaaagag      360

cttaacctgc tctttactgc taaaaactcc cctgaagagt tagaccttaa cattattgag      420

tggatagctt attcaaatga tgaaggatac ttgtctttaa aattcaccag aaccatagaa      480

ccatatatct ctagccttat tgggaaaaaa aataaattca caacgcaatt gttaacggca      540

agcttacgct taagtagcca gtattcatct tctctttatc aacttatcag gaagcattac      600

tctaatttta agaagaaaaa ttattttatt atttccgttg atgagttaaa ggaagagtta      660

atagcttata cttttgataa agatggaaat attgagtaca aataccctga ctttcctatt      720

tttaaaaggg atgtgttaaa taaagccatt gctgaaatta aaaagaaaac agaaatatcg      780

tttgttggct tcactgttca tgaaaaagaa ggaagaaaaa ttagtaagct gaagttcgaa      840

tttgtcgttg atgaagatga attttctggc gataaagatg atgaagcttt ttttatgaat      900

ttatctgaag ctgatgcagc ttttctcaag gtatttgatg aaaccgtacc tcccaaaaaa      960

gctaaggggt gaggatctcc aggcatcaaa taaaacgaaa ggctcagtcg aaagactggg     1020

cctttcgttt tatctgttgt ttgtcggtga acgctctcta ctagagtcac actggctcac     1080

cttcgggtgg gcctttctgc gtttataccc gggaaaaaga gtattgactt aaagtctaac     1140

ctataggtat aatgtgtgga gaccagaggt aaggaggtaa caaccatgcg agtgttgaag     1200

aaacatctta atcatgctaa ggaggttttc taatgcatac cacccgactg aagagggttg     1260

gcggctcagt tatgctgacc gtcccaccgg cactgctgaa tgcgctgtct ctgggcacag     1320

ataatgaagt tggcatggtc attgataatg gccggctgat tgttgagccg tacagacgcc     1380

cgcaatattc actggctgag ctactggcac agtgtgatcc gaatgctgaa atatcagctg     1440

aagaacgaga atggctggat gcaccggcga ctggtcagga ggaaatctga                1490


<210> 1006
<211> 1490
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Biosafety Chromosomal Construct -  medium copy Rep
      (Pi) and Kis antitoxin (as shown in Fig. 76D)"

<400> 1006
ttgacggcta gctcagtcct aggtacagtg ctagcggatc ttccggaaga ctaggtgaga       60

ctcaaggtca tgatggacgt gaacaaaaaa acgaaaattc gccaccgaaa cgagctaaat      120

cacaccctgg ctcaacttcc tttgcccgca aagcgagtga tgtatatggc gcttgctccc      180

attgatagca aagaacctct tgaacgaggg cgagttttca aaattagggc tgaagacctt      240

gcagcgctcg ccaaaatcac cccatcgctt gcttatcgac aattaaaaga gggtggtaaa      300

ttacttggtg ccagcaaaat ttcgctaaga ggggatgata tcattgcttt agctaaagag      360

cttaacctgc tctttactgc taaaaactcc cctgaagagt tagaccttaa cattattgag      420

tggatagctt attcaaatga tgaaggatac ttgtctttaa aattcaccag aaccatagaa      480

ccatatatct ctagccttat tgggaaaaaa aataaattca caacgcaatt gttaacggca      540

agcttacgct taagtagcca gtattcatct tctctttatc aacttatcag gaagcattac      600

tctaatttta agaagaaaaa ttattttatt atttccgttg atgagttaaa ggaagagtta      660

atagcttata cttttgataa agatggaaat attgagtaca aataccctga ctttcctatt      720

tttaaaaggg atgtgttaaa taaagccatt gctgaaatta aaaagaaaac agaaatatcg      780

tttgttggct tcactgttca tgaaaaagaa ggaagaaaaa ttagtaagct gaagttcgaa      840

tttgtcgttg atgaagatga attttctggc gataaagatg atgaagcttt ttttatgaat      900

ttatctgaag ctgatgcagc ttttctcaag gtatttgatg aaaccgtacc tcccaaaaaa      960

gctaaggggt gaggatctcc aggcatcaaa taaaacgaaa ggctcagtcg aaagactggg     1020

cctttcgttt tatctgttgt ttgtcggtga acgctctcta ctagagtcac actggctcac     1080

cttcgggtgg gcctttctgc gtttataccc gggaaaaaga gtattgactt aaagtctaac     1140

ctataggtat aatgtgtgga gaccagaggt aaggaggtaa caaccatgcg agtgttgaag     1200

aaacatctta atcatgctaa ggaggttttc taatgcatac cacccgactg aagagggttg     1260

gcggctcagt tatgctgacc gtcccaccgg cactgctgaa tgcgctgtct ctgggcacag     1320

ataatgaagt tggcatggtc attgataatg gccggctgat tgttgagccg tacagacgcc     1380

cgcaatattc actggctgag ctactggcac agtgtgatcc gaatgctgaa atatcagctg     1440

aagaacgaga atggctggat gcaccggcga ctggtcagga ggaaatctga                1490


<210> 1007
<211> 917
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Rep (Pi)"

<400> 1007
tgagactcaa ggtcatgatg gacgtgaaca aaaaaacgaa aattcgccac cgaaacgagc       60

taaatcacac cctggctcaa cttcctttgc ccgcaaagcg agtgatgtat atggcgcttg      120

ctcccattga tagcaaagaa cctcttgaac gagggcgagt tttcaaaatt agggctgaag      180

accttgcagc gctcgccaaa atcaccccat cgcttgctta tcgacaatta aaagagggtg      240

gtaaattact tggtgccagc aaaatttcgc taagagggga tgatatcatt gctttagcta      300

aagagcttaa cctgctcttt actgctaaaa actcccctga agagttagac cttaacatta      360

ttgagtggat agcttattca aatgatgaag gatacttgtc tttaaaattc accagaacca      420

tagaaccata tatctctagc cttattggga aaaaaaataa attcacaacg caattgttaa      480

cggcaagctt acgcttaagt agccagtatt catcttctct ttatcaactt atcaggaagc      540

attactctaa ttttaagaag aaaaattatt ttattatttc cgttgatgag ttaaaggaag      600

agttaatagc ttatactttt gataaagatg gaaatattga gtacaaatac cctgactttc      660

ctatttttaa aagggatgtg ttaaataaag ccattgctga aattaaaaag aaaacagaaa      720

tatcgtttgt tggcttcact gttcatgaaa aagaaggaag aaaaattagt aagctgaagt      780

tcgaatttgt cgttgatgaa gatgaatttt ctggcgataa agatgatgaa gcttttttta      840

tgaatttatc tgaagctgat gcagcttttc tcaaggtatt tgatgaaacc gtacctccca      900

aaaaagctaa ggggtga                                                     917


<210> 1008
<211> 255
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Kis antitoxin"

<400> 1008
cataccaccc gactgaagag ggttggcggc tcagttatgc tgaccgtccc accggcactg       60

ctgaatgcgc tgtctctggg cacagataat gaagttggca tggtcattga taatggccgg      120

ctgattgttg agccgtacag acgcccgcaa tattcactgg ctgagctact ggcacagtgt      180

gatccgaatg ctgaaatatc agctgaagaa cgagaatggc tggatgcacc ggcgactggt      240

caggaggaaa tctga                                                       255


<210> 1009
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RBS (low copy)"

<400> 1009
gctggaacag gtgg                                                         14


<210> 1010
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="RBS (medium copy)"

<400> 1010
tccggaagac tagg                                                         14


<210> 1011
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="SR36"

<400> 1011
tagaactgat gcaaaaagtg ctcgacgaag gcacacagat gtgtaggctg gagctgcttc       60


<210> 1012
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="SR38"

<400> 1012
gtttcgtaat tagatagcca ccggcgcttt aatgcccgga catatgaata tcctccttag       60


<210> 1013
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="SR33"

<400> 1013
caacacgttt cctgaggaac catgaaacag tatttagaac tgatgcaaaa ag               52


<210> 1014
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="SR43"

<400> 1014
atatcgtcgc agcccacagc aacacgtttc ctgagg                                 36


<210> 1015
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="SR44"

<400> 1015
aagaatttaa cggagggcaa aaaaaaccga cgcacactgg cgtcggc                     47


<210> 1016
<211> 967
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Wild-type clbA"

<400> 1016
caaatatcac ataatcttaa catatcaata aacacagtaa agtttcatgt gaaaaacatc       60

aaacataaaa tacaagctcg gaatacgaat cacgctatac acattgctaa caggaatgag      120

attatctaaa tgaggattga tatattaatt ggacatacta gtttttttca tcaaaccagt      180

agagataact tccttcacta tctcaatgag gaagaaataa aacgctatga tcagtttcat      240

tttgtgagtg ataaagaact ctatatttta agccgtatcc tgctcaaaac agcactaaaa      300

agatatcaac ctgatgtctc attacaatca tggcaattta gtacgtgcaa atatggcaaa      360

ccatttatag tttttcctca gttggcaaaa aagatttttt ttaacctttc ccatactata      420

gatacagtag ccgttgctat tagttctcac tgcgagcttg gtgtcgatat tgaacaaata      480

agagatttag acaactctta tctgaatatc agtcagcatt tttttactcc acaggaagct      540

actaacatag tttcacttcc tcgttatgaa ggtcaattac ttttttggaa aatgtggacg      600

ctcaaagaag cttacatcaa atatcgaggt aaaggcctat ctttaggact ggattgtatt      660

gaatttcatt taacaaataa aaaactaact tcaaaatata gaggttcacc tgtttatttc      720

tctcaatgga aaatatgtaa ctcatttctc gcattagcct ctccactcat cacccctaaa      780

ataactattg agctatttcc tatgcagtcc caactttatc accacgacta tcagctaatt      840

cattcgtcaa atgggcagaa ttgaatcgcc acggataatc tagacacttc tgagccgtcg      900

ataatattga ttttcatatt ccgtcggtgg tgtaagtatc ccgcataatc gtgccattca      960

catttag                                                                967


<210> 1017
<211> 424
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="clbA knockout"

<400> 1017
ggatgggggg aaacatggat aagttcaaag aaaaaaaccc gttatctctg cgtgaaagac       60

aagtattgcg catgctggca caaggtgatg agtactctca aatatcacat aatcttaaca      120

tatcaataaa cacagtaaag tttcatgtga aaaacatcaa acataaaata caagctcgga      180

atacgaatca cgctatacac attgctaaca ggaatgagat tatctaaatg aggattgatg      240

tgtaggctgg agctgcttcg aagttcctat actttctaga gaataggaac ttcggaatag      300

gaacttcgga ataggaacta aggaggatat tcatatgtcg tcaaatgggc agaattgaat      360

cgccacggat aatctagaca cttctgagcc gtcgataata ttgattttca tattccgtcg      420

gtgg                                                                   424


<210> 1018
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Master Sequence"


<220>
<221> modified_base
<222> (13)..(15)
<223> a, c, g or t

<220>
<221> modified_base
<222> (18)..(20)
<223> a, c, g or t

<400> 1018
tctagagaaa gannngannn actagatg                                          28


<210> 1019
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61100"

<400> 1019
tctagagaaa gaggggacaa actagatg                                          28


<210> 1020
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61101"

<400> 1020
tctagagaaa gacaggaccc actagatg                                          28


<210> 1021
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61102"

<400> 1021
tctagagaaa gatccgatgt actagatg                                          28


<210> 1022
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61103"

<400> 1022
tctagagaaa gattagacaa actagatg                                          28


<210> 1023
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61104"

<400> 1023
tctagagaaa gaagggacag actagatg                                          28


<210> 1024
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61105"

<400> 1024
tctagagaaa gacatgacgt actagatg                                          28


<210> 1025
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61106"

<400> 1025
tctagagaaa gataggagac actagatg                                          28


<210> 1026
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61107"

<400> 1026
tctagagaaa gaagagactc actagatg                                          28


<210> 1027
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61108"

<400> 1027
tctagagaaa gacgagatat actagatg                                          28


<210> 1028
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61109"

<400> 1028
tctagagaaa gactggagac actagatg                                          28


<210> 1029
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61110"

<400> 1029
tctagagaaa gaggcgaatt actagatg                                          28


<210> 1030
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61111"

<400> 1030
tctagagaaa gaggcgatac actagatg                                          28


<210> 1031
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61112"

<400> 1031
tctagagaaa gaggtgacat actagatg                                          28


<210> 1032
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61113"

<400> 1032
tctagagaaa gagtggaaaa actagatg                                          28


<210> 1033
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61114"

<400> 1033
tctagagaaa gatgagaaga actagatg                                          28


<210> 1034
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61115"

<400> 1034
tctagagaaa gaagggatac actagatg                                          28


<210> 1035
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61116"

<400> 1035
tctagagaaa gacatgaggc actagatg                                          28


<210> 1036
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61117"

<400> 1036
tctagagaaa gacatgagtt actagatg                                          28


<210> 1037
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61118"

<400> 1037
tctagagaaa gagacgaatc actagatg                                          28


<210> 1038
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61119"

<400> 1038
tctagagaaa gatttgatat actagatg                                          28


<210> 1039
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61120"

<400> 1039
tctagagaaa gacgcgagaa actagatg                                          28


<210> 1040
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61121"

<400> 1040
tctagagaaa gagacgagtc actagatg                                          28


<210> 1041
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61122"

<400> 1041
tctagagaaa gagaggagcc actagatg                                          28


<210> 1042
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61123"

<400> 1042
tctagagaaa gagatgacta actagatg                                          28


<210> 1043
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61124"

<400> 1043
tctagagaaa gagccgacat actagatg                                          28


<210> 1044
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61125"

<400> 1044
tctagagaaa gagccgagtt actagatg                                          28


<210> 1045
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61126"

<400> 1045
tctagagaaa gaggtgactc actagatg                                          28


<210> 1046
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61127"

<400> 1046
tctagagaaa gagtggaact actagatg                                          28


<210> 1047
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61128"

<400> 1047
tctagagaaa gataggactc actagatg                                          28


<210> 1048
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61129"

<400> 1048
tctagagaaa gattggacgt actagatg                                          28


<210> 1049
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61130"

<400> 1049
tctagagaaa gaaacgacat actagatg                                          28


<210> 1050
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="BBa_J61131"

<400> 1050
tctagagaaa gaaccgaatt actagatg                                          28


<210> 1051
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="polypeptide linker"

<400> 1051
Ser Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala 
1               5                   10                  15      


Lys Lys Asp Asp Ala Lys Lys Asp Ala Ser 
            20                  25      


<210> 1052
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="polypeptide linker"

<400> 1052
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 1053
<211> 197
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1053
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 1054
<211> 306
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1054
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210> 1055
<211> 197
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1055
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 1056
<211> 313
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1056
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser 
305                 310             


<210> 1057
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1057
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 1058
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1058
Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210> 1059
<211> 177
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1059
Gly Pro Gln Arg Glu Glu Phe Pro Arg Asp Leu Ser Leu Ile Ser Pro 
1               5                   10                  15      


Leu Ala Gln Ala Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro 
            20                  25                  30          


Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp 
        35                  40                  45              


Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg 
    50                  55                  60                  


Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser 
65                  70                  75                  80  


Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu 
                85                  90                  95      


Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn 
            100                 105                 110         


Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly 
        115                 120                 125             


Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe 
    130                 135                 140                 


Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp 
145                 150                 155                 160 


Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala 
                165                 170                 175     


Leu 
    


<210> 1060
<211> 138
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1060
Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe Asn 
1               5                   10                  15      


Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly Ile 
            20                  25                  30          


Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp Gln 
    50                  55                  60                  


Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val Lys 
65                  70                  75                  80  


Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu Thr 
                85                  90                  95      


Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His Glu 
            100                 105                 110         


Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly Lys 
        115                 120                 125             


Arg Lys Arg Ser Gln Met Leu Phe Arg Gly 
    130                 135             


<210> 1061
<211> 73
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1061
Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys Ile Ser Ile Ser Asn 
1               5                   10                  15      


Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu Glu Ile Ile Pro Ala 
            20                  25                  30          


Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala Thr Met Lys Lys Lys 
        35                  40                  45              


Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys Ala Ile Lys Asn Leu 
    50                  55                  60                  


Leu Lys Ala Val Ser Lys Glu Arg Ser 
65                  70              


<210> 1062
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1062
Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210> 1063
<211> 594
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1063
aggaacctgc ctgtggcaac accagaccct gggatgttcc cttgcttaca tcattcccag       60

aacctgttgc gtgcggtgtc taacatgctg cagaaagcca ggcagacgct ggaattctac      120

ccatgcactt ccgaagagat agatcatgaa gacattacga aagacaaaac ctcaacggtt      180

gaagcatgct tacctctgga attgactaag aatgaatcgt gcttaaactc aagagagacc      240

agtttcatca ctaatggctc ttgcttagcg tcgcgcaaga ccagcttcat gatggcgctc      300

tgcctaagta gcatctacga ggacctcaaa atgtaccaag ttgaatttaa aactatgaat      360

gccaaacttc taatggaccc aaaaagacag atatttttag atcagaatat gcttgcggtt      420

attgacgaac tcatgcaggc attgaatttt aattccgaga cggtgccaca aaaaagttct      480

ttggaggagc cggactttta caagacaaaa atcaagctgt gcatacttct tcacgcattc      540

agaatacggg ccgttacgat cgatcgcgtc atgtcgtatc ttaatgcgag ctga            594


<210> 1064
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1064
atctgggaac tgaaaaaaga tgtttatgta gttgaactgg attggtaccc ggatgcaccc       60

ggtgagatgg tggttttgac ctgcgacacg ccggaagaag atggcataac gtggaccctg      120

gatcaaagct ctgaagttct gggttcaggt aagacattga cgatccaagt aaaagaattt      180

ggcgacgcag gtcagtacac ctgccacaaa ggtggcgaag ttctgtcgca ctcactcctg      240

ctcctgcaca aaaaagagga tggcatctgg agtactgata tcctaaagga tcaaaaagaa      300

cctaaaaaca aaacgttctt gcgctgtgaa gcgaagaact atagtggtcg ctttacgtgc      360

tggtggttga ctaccatttc caccgatttg accttttctg ttaagagttc gcgcggctcg      420

tcagatccgc agggcgttac ttgcggtgcg gcgacgctgt cagctgagag agttcgtggg      480

gacaacaaag agtacgaata tagtgtagaa tgtcaagagg attcggcgtg cccggcagca      540

gaggagtctc tccccattga agttatggtg gacgcagtgc ataaactgaa atatgagaat      600

tacacatcaa gcttttttat tcgcgatatc atcaaaccgg atcctccaaa aaatctgcaa      660

ctaaagcccc tgaaaaattc gcgccaagtt gaggtgagct gggaatatcc ggatacttgg      720

tcgacaccgc attcttattt ctcactgacc ttctgcgttc aggttcaagg taaatcaaaa      780

cgagaaaaaa aggatcgcgt ctttaccgac aaaacgtctg ctactgtaat ctgccgcaag      840

aatgcgtcaa tttctgtacg tgcgcaagat cgctactact ctagtagttg gtctgaatgg      900

gcttcagtgc catgctcctg atga                                             924


<210> 1065
<211> 594
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1065
cgtaaccttc cggtggccac gccagatccg ggcatgttcc cgtgcttaca ccattcccag       60

aatctgctgc gcgctgtgag taatatgctg cagaaggcga gacaaacttt ggaattttac      120

ccgtgcactt cggaggagat tgaccatgag gatatcacaa aagacaaaac cagtacagtg      180

gaagcctgcc tgccccttga actgactaaa aatgagagtt gtttaaattc acgcgaaacc      240

agcttcatta ctaacggaag ctgcttagca tcgcggaaaa ccagttttat gatggccctt      300

tgcctttcat ctatttacga ggaccttaaa atgtatcaag ttgaatttaa gactatgaac      360

gcgaaactgc taatggatcc caagcgacaa atctttcttg atcaaaatat gttggctgtt      420

attgatgaac tgatgcaagc cctgaatttt aactcagaaa ccgtacctca gaaatcgagt      480

ttagaagaac ccgatttcta caaaactaaa atcaagttgt gtatcctttt acatgccttc      540

cggattcggg ccgtcactat tgatcgcgtg atgtcgtact tgaatgcctc ctaa            594


<210> 1066
<211> 942
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1066
atgtgggaat tggaaaaaga cgtgtatgtt gttgaagttg actggactcc ggacgcgcct       60

ggtgaaactg ttaatctgac ttgtgataca ccggaggaag atgatataac ttggactagc      120

gatcaacgac acggcgtaat cggctctggt aagactttga ccattactgt gaaggaattc      180

ttggatgcgg ggcaatatac gtgtcataaa ggcggcgaga cgctgtcaca ctctcacctg      240

ttgttacata aaaaagagaa tggtatatgg tctacggaga tcttgaaaaa ctttaaaaac      300

aaaacttttt tgaagtgtga ggctccaaac tattctggtc gctttacctg tagttggttg      360

gtgcaacgta acatggatct caaatttaac ataaagtcgt cttcgtcttc tcccgatagc      420

cgagcggtta cctgtggcat ggctagtttg tcggcggaga aggtgacctt ggatcaacgt      480

gattatgaaa aatatagcgt ttcgtgccaa gaggacgtta cgtgccctac cgctgaagag      540

actttgccga ttgaattggc actggaagca cgacaacaaa ataaatacga gaattactca      600

actagtttct tcatccgaga tatcataaaa ccggaccccc cgaagaatct gcaaatgaaa      660

ccgcttaaaa attcacaggt agaggtttcg tgggagtacc cggatagttg gtctacgcct      720

cattcgtatt ttagcctgaa atttttcgtt cgaatacagc gaaaaaaaga gaagatgaaa      780

gaaactgaag aagggtgtaa ccaaaaaggt gcatttctgg tggagaaaac tagcaccgag      840

gttcaatgca aaggcggtaa cgtgtgcgta caagctcaag accgttatta taacagtagc      900

tgttctaaat gggcttgcgt gccctgccgc gtgagatcat ga                         942


<210> 1067
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1067
aattgggtta atgttatatc tgatttgaaa aaaatagagg atctgattca atcaatgcac       60

atagatgcga ctctgtatac tgagagcgat gtgcacccga gttgcaaagt tactgctatg      120

aaatgttttc tgctggagct gcaagttatc tctctggaga gtggtgatgc gtctattcac      180

gatactgttg agaatctgat tattctggct aataactcgc tgtcaagtaa tgggaatgtt      240

acggaatctg gctgtaagga gtgtgaagaa ttagaagaaa aaaatattaa agagtttctg      300

cagagttttg tgcacattgt tcagatgttt atcaatacta gctga                      345


<210> 1068
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1068
gcaccggccc gcagcccatc accgtcaact caaccttggg aacatgtaaa tgctattcaa       60

gaagctcgcc gcctgttgaa tttgagtcgc gatactgcag cagagatgaa tgagactgta      120

gaggtgattt cagaaatgtt tgacctgcag gagccgactt gtttgcaaac tcgcctggag      180

ctgtacaaac aaggcctgcg tggctcgctg actaaactga aaggtcctct gacgatgatg      240

gcttctcatt ataaacaaca ctgcccgcct actccggaga cgtcttgcgc gacccagata      300

attacttttg aatcttttaa agagaatctg aaagactttc tgctggttat cccgtttgat      360

tgttgggaac cggttcaaga ataa                                             384


<210> 1069
<211> 534
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1069
ggtccgcaga gggaagaatt cccgcgcgat ttgagcctga tttcacctct tgctcaggct       60

gtccgctcct cttcgcgtac cccctcggat aaacctgtcg cgcacgtggt tgcgaacccg      120

caagcggaag ggcagctgca atggttaaac cgccgggcta atgcactgct ggctaatgga      180

gttgagttac gcgacaacca acttgtcgtt ccttcggaag ggctgtatct gatctattca      240

caggttctct ttaaagggca gggttgccca tcaacccacg tgctcctgac acacacgatc      300

agtcgtatcg cggtatccta tcagacgaaa gttaacctcc tgtcagcgat taaatcgccg      360

tgtcagagag aaactccaga gggtgcggaa gctaaaccgt ggtatgaacc tatttatctt      420

ggtggagttt tccagttgga aaaaggtgat agactgtcgg cagagatcaa tcgccctgat      480

tacctggatt tcgctgagtc gggtcaggtt tatttcggaa ttattgcact gtga            534


<210> 1070
<211> 417
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1070
caggatcctt acgttaaaga agcagagaat ctgaaaaaat actttaatgc aggccacagc       60

gatgtggcag ataatggcac gttattcctg ggcattctga aaaattggaa agaagaatct      120

gaccggaaga tcatgcaatc tcagatcgta tcattttatt tcaagttgtt taaaaacttc      180

aaggatgacc agtcgattca aaaatcagtg gaaacgatca aagaagatat gaacgttaag      240

ttcttcaact caaataaaaa aaaacgcgat gatttcgaaa aactgactaa ttattcggta      300

actgatttga atgttcagcg caaggcgatt catgaattga ttcaggttat ggcagaactg      360

tcgccagcgg caaaaacggg taaacgaaaa cgttctcaga tgttgtttcg tggttga         417


<210> 1071
<211> 222
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1071
gtgcccctga gccgcaccgt gcgttgtacg tgtatctcca tctcaaacca gccggtaaac       60

ccgcgtagtt tagaaaaact ggagattatc ccagccagcc agttttgccc gcgcgttgag      120

attattgcga ccatgaagaa aaaaggggaa aaacgttgcc ttaatccaga aagtaaggct      180

atcaaaaacc tgttgaaagc tgtctcgaaa gagcgttcct aa                         222


<210> 1072
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1072
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Val Pro Leu Ser Arg Thr Val Arg Cys Thr 
            20                  25                  30          


Cys Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys 
        35                  40                  45              


Leu Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile 
    50                  55                  60                  


Ala Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser 
65                  70                  75                  80  


Lys Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser 
                85                  90                  95  


<210> 1073
<211> 94
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1073
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser 
                85                  90                  


<210> 1074
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1074
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Val Pro Leu Ser Arg Thr Val Arg Cys 
        35                  40                  45              


Thr Cys Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu 
    50                  55                  60                  


Lys Leu Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile 
65                  70                  75                  80  


Ile Ala Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu 
                85                  90                  95      


Ser Lys Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser 
            100                 105                 110         


<210> 1075
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1075
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210> 1076
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1076
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Thr Pro Val Val Arg Lys Gly Arg Cys Ser Cys 
            20                  25                  30          


Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp Leu 
        35                  40                  45              


Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile Ala 
    50                  55                  60                  


Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala Asp 
65                  70                  75                  80  


Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys Lys 
                85                  90                  95      


Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys Val 
            100                 105                 110         


Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 


<210> 1077
<211> 142
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1077
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Thr Pro Val Val Arg Lys Gly Arg Cys 
        35                  40                  45              


Ser Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys 
    50                  55                  60                  


Asp Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile 
65                  70                  75                  80  


Ile Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser 
                85                  90                  95      


Ala Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln 
            100                 105                 110         


Lys Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu 
        115                 120                 125             


Lys Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
    130                 135                 140         


<210> 1078
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1078
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Thr Leu Val Ile Arg Asn Ala Arg Cys Ser Cys 
            20                  25                  30          


Ile Ser Thr Ser Arg Gly Thr Ile His Tyr Lys Ser Leu Lys Asp Leu 
        35                  40                  45              


Lys Gln Phe Ala Pro Ser Pro Asn Cys Asn Lys Thr Glu Ile Ile Ala 
    50                  55                  60                  


Thr Leu Lys Asn Gly Asp Gln Thr Cys Leu Asp Pro Asp Ser Ala Asn 
65                  70                  75                  80  


Val Lys Lys Leu Met Lys Glu Trp Glu Lys Lys Ile Ser Gln Lys Lys 
                85                  90                  95      


Lys Gln Lys Arg Gly Lys Lys His Gln Lys Asn Met Lys Asn Arg Lys 
            100                 105                 110         


Pro Lys Thr Pro Gln Ser Arg Arg Arg Ser Arg Lys Thr Thr 
        115                 120                 125     


<210> 1079
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1079
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Thr Leu Val Ile Arg Asn Ala Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Ser Arg Gly Thr Ile His Tyr Lys Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Asn Cys Asn Lys Thr Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Asp Gln Thr Cys Leu Asp Pro Asp Ser Ala 
65                  70                  75                  80  


Asn Val Lys Lys Leu Met Lys Glu Trp Glu Lys Lys Ile Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Arg Gly Lys Lys His Gln Lys Asn Met Lys Asn Arg 
            100                 105                 110         


Lys Pro Lys Thr Pro Gln Ser Arg Arg Arg Ser Arg Lys Thr Thr 
        115                 120                 125         


<210> 1080
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1080
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Thr Leu Val Ile Arg Asn Ala Arg Cys 
        35                  40                  45              


Ser Cys Ile Ser Thr Ser Arg Gly Thr Ile His Tyr Lys Ser Leu Lys 
    50                  55                  60                  


Asp Leu Lys Gln Phe Ala Pro Ser Pro Asn Cys Asn Lys Thr Glu Ile 
65                  70                  75                  80  


Ile Ala Thr Leu Lys Asn Gly Asp Gln Thr Cys Leu Asp Pro Asp Ser 
                85                  90                  95      


Ala Asn Val Lys Lys Leu Met Lys Glu Trp Glu Lys Lys Ile Ser Gln 
            100                 105                 110         


Lys Lys Lys Gln Lys Arg Gly Lys Lys His Gln Lys Asn Met Lys Asn 
        115                 120                 125             


Arg Lys Pro Lys Thr Pro Gln Ser Arg Arg Arg Ser Arg Lys Thr Thr 
    130                 135                 140                 


<210> 1081
<211> 285
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1081
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctgtgcccc tgagccgcac cgtgcgttgt acgtgtatct ccatctcaaa ccagccggta      120

aacccgcgta gtttagaaaa actggagatt atcccagcca gccagttttg cccgcgcgtt      180

gagattattg cgaccatgaa gaaaaaaggg gaaaaacgtt gccttaatcc agaaagtaag      240

gctatcaaaa acctgttgaa agctgtctcg aaagagcgtt cctaa                      285


<210> 1082
<211> 297
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1082
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctatcccac tggctcgcac agtccgctgt aattgcatcc acatcgatga cggtcctgtg      120

cgtatgcgtg caatcggtaa acttgaaatt atccctgcct ccttatcgtg tccccgcgta      180

gagattatcg ccacgatgaa gaaaaacgat gaacagcgtt gtcttaaccc agagagcaaa      240

actatcaaaa acctgatgaa ggcttttagt caaaagcgca gtaagcgcgc accataa         297


<210> 1083
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1083
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctacacccg tagtgcgtaa agggcgctgc agttgcatct cgactaacca ggggacaatc      120

cacctgcagt cgctgaaaga tttgaagcag tttgcaccga gccctagttg tgaaaaaatc      180

gagatcatcg ctacattaaa gaacggcgtc caaacatgtc ttaaccccga ctcagcagat      240

gttaaagaac ttattaagaa atgggagaag caggtaagtc agaaaaagaa acagaaaaat      300

ggcaagaaac atcagaaaaa gaaagtctta aaggttcgta aatcgcagcg ttctcgtcaa      360

aagaagacga cgtaa                                                       375


<210> 1084
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1084
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctacgctgg tgatccgtaa cgcccgctgt tcatgcatca gcacttctcg tggaaccatc      120

cactataaat cattaaagga cttgaaacag tttgcacctt caccaaattg taacaagacg      180

gaaattattg ctactctgaa aaacggagat caaacttgcc tggaccccga ctctgcaaac      240

gtgaagaagc tgatgaagga atgggaaaaa aaaatctctc aaaagaaaaa gcaaaagcgc      300

ggtaagaaac atcagaagaa catgaagaat cgtaagccaa agacccctca gtcgcgccgt      360

cgttctcgta agacgacgta a                                                381


<210> 1085
<211> 284
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1085
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctgtgcccc tgagccgcac cgtgcgttgt acgtgtatct ccatctcaaa ccagccggta      120

aacccgcgta gtttagaaaa actggagatt atcccagcca gccagttttg cccgcgcgtt      180

gagattattg cgaccatgaa gaaaaaaggg gaaaaacgtt gccttaatcc agaaagtaag      240

gctatcaaaa acctgttgaa agctgtctcg aaagagcgtt ccta                       284


<210> 1086
<211> 1204
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1086
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaaataag tttatcaaaa taaaaggagg taatatatga      780

agcagagcac catcgcgctt gccctgctgc cgttgctttt cacgcctgtc accaaggcta      840

tcccactggc tcgcacagtc cgctgtaatt gcatccacat cgatgacggt cctgtgcgta      900

tgcgtgcaat cggtaaactt gaaattatcc ctgcctcctt atcgtgtccc cgcgtagaga      960

ttatcgccac gatgaagaaa aacgatgaac agcgttgtct taacccagag agcaaaacta     1020

tcaaaaacct gatgaaggct tttagtcaaa agcgcagtaa gcgcgcacca taaaacgatt     1080

ggtaaacccg gtgaacgcat gagaaagccc ccggaagatc accttccggg ggctttttta     1140

ttgcgcggac caaaacgaaa aaagacgctc gaaagcgtct cttttctgga atttggtacc     1200

gagg                                                                  1204


<210> 1087
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1087
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctacacccg tagtgcgtaa agggcgctgc agttgcatct cgactaacca ggggacaatc      120

cacctgcagt cgctgaaaga tttgaagcag tttgcaccga gccctagttg tgaaaaaatc      180

gagatcatcg ctacattaaa gaacggcgtc caaacatgtc ttaaccccga ctcagcagat      240

gttaaagaac ttattaagaa atgggagaag caggtaagtc agaaaaagaa acagaaaaat      300

ggcaagaaac atcagaaaaa gaaagtctta aaggttcgta aatcgcagcg ttctcgtcaa      360

aagaagacga cgtaa                                                       375


<210> 1088
<211> 1288
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1088
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaaataag tttatcaaaa taaaaggagg taatatatga      780

agcagagcac catcgcgctt gccctgctgc cgttgctttt cacgcctgtc accaaggcta      840

cgctggtgat ccgtaacgcc cgctgttcat gcatcagcac ttctcgtgga accatccact      900

ataaatcatt aaaggacttg aaacagtttg caccttcacc aaattgtaac aagacggaaa      960

ttattgctac tctgaaaaac ggagatcaaa cttgcctgga ccccgactct gcaaacgtga     1020

agaagctgat gaaggaatgg gaaaaaaaaa tctctcaaaa gaaaaagcaa aagcgcggta     1080

agaaacatca gaagaacatg aagaatcgta agccaaagac ccctcagtcg cgccgtcgtt     1140

ctcgtaagac gacgtaaaac gattggtaaa cccggtgaac gcatgagaaa gcccccggaa     1200

gatcaccttc cgggggcttt tttattgcgc ggaccaaaac gaaaaaagac gctcgaaagc     1260

gtctcttttc tggaatttgg taccgagg                                        1288


<210> 1089
<211> 858
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1089
aaacaatcga ccatcgcatt ggcgctgctt cctctattgt tcacaccggt gacaaaggca       60

gtcgactata aggatgacga cgacaagcaa ttgggcggtg gccaccgtcg tttggacaag      120

gtggaggagg aagtcaactt gcatgaagat tttgtattta tcaagaaatt aaagcgttgt      180

aacaagggtg aagggagctt gagtttactt aactgtgaag aaatgcgccg ccaattcgag      240

gacttggtta aggacattac ccttaacaag gaagaaaaga aagagaacag cttcgaaatg      300

cagcgtggcg atgaagaccc ccagatcgcg gcacatgtcg tttccgaggc aaattcgaat      360

gctgcttcag tcttacaatg ggcgaaaaag ggctactaca cgatgaagtc aaacttagtg      420

atgcttgaaa atggcaagca attaaccgtg aagcgcgaag gattgtatta tgtctacacc      480

caagtaacat tttgctccaa tcgcgaaccg tcgtcgcagc gccctttcat cgttggtttg      540

tggttgaagc cgagctccgg ttccgagcgt attcttttga aagccgcaaa cacccacagc      600

agctcgcagc tgtgtgaaca gcagagcgtc cacctgggcg gcgtatttga attgcaagcg      660

ggagcgtcag ttttcgttaa tgtgactgag gcttctcaag ttatccatcg tgtcggtttc      720

tccagcttcg gcttactgaa gttaaagggc gagctcaatt cgaagcttga aggtaagcct      780

atccctaacc ctctcctcgg cctcgattct acggatccga attcgagctc cgtcgaccat      840

caccatcacc accactga                                                    858


<210> 1090
<211> 791
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1090
tgactagtaa acaatcgacc atcgcattgg cgctgcttcc tctattgttc acaccggtga       60

caaaggcagt cgactataag gatgacgacg acaagcaatt gggcggtggc atgcaacgtg      120

gcgatgagga cccgcaaatt gccgcgcatg ttgtgtccga agcgaactcc aatgccgcat      180

ccgtcctgca atgggctaag aaaggctatt acacgatgaa atcaaacctg gttatgcttg      240

agaacggaaa gcagcttaca gtcaagcgtg agggcctgta ttacgtctac acccaagtta      300

ccttttgctc taaccgtgag cccagcagcc aacgcccttt tattgtaggc ctgtggttaa      360

agccctcgtc gggttctgaa cgcattcttc tgaaagctgc gaatacgcac tctagtagcc      420

agctgtgtga gcaacaatct gtccatcttg gtggagtttt tgagttacaa gctggagcat      480

ctgtgttcgt gaatgtaacg gaagcatctc aagttatcca ccgtgtaggc ttctcatctt      540

ttggtttatt aaaattaaag ggcgagctca attcgaagct tgaaggtaag cctatcccta      600

accctctcct cggcctcgat tctacggatc cgaattcgag ctccgtcgac catcaccatc      660

accaccactg agcatgctaa tcagccgtgg aattcggtct caggaggatc agttctggac      720

cagcgagctg tgctgcgact cgtggcgtaa tcatggtcat agctgtttcc tgtgtgaaat      780

tgttatccgc t                                                           791


<210> 1091
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1091
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly His Arg Arg Leu Asp Lys Val Glu Glu Glu Val 
        35                  40                  45              


Asn Leu His Glu Asp Phe Val Phe Ile Lys Lys Leu Lys Arg Cys Asn 
    50                  55                  60                  


Lys Gly Glu Gly Ser Leu Ser Leu Leu Asn Cys Glu Glu Met Arg Arg 
65                  70                  75                  80  


Gln Phe Glu Asp Leu Val Lys Asp Ile Thr Leu Asn Lys Glu Glu Lys 
                85                  90                  95      


Lys Glu Asn Ser Phe Glu Met Gln Arg Gly Asp Glu Asp Pro Gln Ile 
            100                 105                 110         


Ala Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu 
        115                 120                 125             


Gln Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met 
    130                 135                 140                 


Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr 
145                 150                 155                 160 


Val Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln 
                165                 170                 175     


Arg Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu 
            180                 185                 190         


Arg Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys 
        195                 200                 205             


Glu Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly 
    210                 215                 220                 


Ala Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg 
225                 230                 235                 240 


Val Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Lys Gly Glu Leu Asn 
                245                 250                 255     


Ser Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
            260                 265                 270         


Ser Thr Asp Pro Asn Ser Ser Ser Val Asp His His His His His His 
        275                 280                 285             


<210> 1092
<211> 223
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1092
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly Met Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala 
        35                  40                  45              


Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln 
    50                  55                  60                  


Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu 
65                  70                  75                  80  


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val 
                85                  90                  95      


Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg 
            100                 105                 110         


Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg 
        115                 120                 125             


Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu 
    130                 135                 140                 


Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala 
145                 150                 155                 160 


Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg Val 
                165                 170                 175     


Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Lys Gly Glu Leu Asn Ser 
            180                 185                 190         


Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
        195                 200                 205             


Thr Asp Pro Asn Ser Ser Ser Val Asp His His His His His His 
    210                 215                 220             


<210> 1093
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1093
His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp 
1               5                   10                  15      


Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser 
            20                  25                  30          


Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe 
        35                  40                  45              


Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser 
    50                  55                  60                  


Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val 
65                  70                  75                  80  


Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu 
                85                  90                  95      


Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly 
            100                 105                 110         


Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln 
        115                 120                 125             


Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile 
    130                 135                 140                 


Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu 
145                 150                 155                 160 


Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser 
                165                 170                 175     


Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe 
            180                 185                 190         


Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr 
        195                 200                 205             


Ser Phe Gly Leu Leu Lys Leu 
    210                 215 


<210> 1094
<211> 1251
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1094
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggcggtgg caaggaactg      120

aaagtcaccc agcctgagaa gtctgtctca gtagcggcag gtgacagcac ggtgcttaac      180

tgcacgctta cttcactgct gccggtaggt cccattaaat ggtatcgtgg cgtgggccaa      240

agtcgtttgt taatctactc ctttacgggt gagcactttc cgcgcgtaac taatgtaagc      300

gacgcaacaa aacgtaacaa catggatttc agcattcgca tctcaaacgt cactcccgag      360

gatgctggga cttactactg cgtaaaattt cagaaaggcc cctcagagcc cgatacagaa      420

atccaatcag gaggcggcac agaagtctac gttctggcaa aaccctctcc ccctgaagtc      480

tccggtccag cagatcgtgg cattcctgac caaaaagtaa atttcacgtg caaatcgcac      540

gggtttagcc cacgcaacat cacactgaag tggtttaaag atggtcagga acttcatcac      600

cttgagacta ccgtgaaccc gtccggtaaa aacgtttcct acaatatctc gtccactgtg      660

cgtgttgtat tgaatagcat ggacgttcac agcaaggtga tctgtgaagt cgctcacatt      720

acccttgacc gttcaccatt gcgtggtatc gcgaacctga gcaatttcat ccgtgtcagc      780

ccgacggtta aggttactca gcagtcccca acatcgatga accaggtaaa tctgacgtgt      840

cgtgcagaac gtttttaccc tgaagacctg cagttgattt ggctggagaa cgggaacgtc      900

tcgcgcaatg acacacccaa aaatctgaca aagaatactg acggtacgta caattataca      960

tcactgtttc ttgtgaactc ctccgcccat cgcgaggacg tagtctttac atgtcaagtc     1020

aagcacgatc agcagcccgc gatcacccgt aatcacacag ttctgggcct ggctcactca     1080

tccgatcagg gatcaatgca aacatttccg ggaaacaatg caacccacaa ctggaataag     1140

ggcgagctca attcgaagct tgaaggtaag cctatcccta accctctcct cggcctcgat     1200

tctacggatc cgaattcgag ctccgtcgac catcaccatc accaccactg a              1251


<210> 1095
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1095
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggtggtag cgaagaagaa      120

ctgcagatta tccaaccgga caaatctgtt ctggtggctg cgggtgaaac ggctactttg      180

cgctgcacaa tcacctcgct gtttccagtc ggaccaatcc aatggttccg tggtgcggga      240

ccgggtcgcg tgttgatcta caatcagcgt caaggccctt tcccccgtgt tactactgtc      300

tccgatacaa caaagcgcaa caacatggac ttttccatcc gtatcgggaa tatcacaccg      360

gccgacgcgg gaacctatta ttgcatcaag tttcgcaagg gatctccaga cgatgttgaa      420

tttaagagcg gggctggaac tgagctgtcc gtgcgtgcaa aaccttcggg cagcggcgag      480

ctcggtggca gtggtaagcc tatccctaac cctctcctcg gcctcgattc tacgggatcc      540

ggtcatcatc accatcacca ttga                                             564


<210> 1096
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1096
gaagaagaac tgcagattat ccaaccggac aaatctgttc tggtggctgc gggtgaaacg       60

gctactttgc gctgcacaat cacctcgctg tttccagtcg gaccaatcca atggttccgt      120

ggtgcgggac cgggtcgcgt gttgatctac aatcagcgtc aaggcccttt cccccgtgtt      180

actactgtct ccgatacaac aaagcgcaac aacatggact tttccatccg tatcgggaat      240

atcacaccgg ccgacgcggg aacctattat tgcatcaagt ttcgcaaggg atctccagac      300

gatgttgaat ttaagagcgg ggctggaact gagctgtccg tgcgtgcaaa accttcg         357


<210> 1097
<211> 945
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1097
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggtggtag cgaggaggaa      120

gtgcaaatca ttcaacccga caaaagcgtt agtgtcgcgg cgggtgagtc cgccatcctg      180

cattgcacta tcacatccct gtttcccgta ggtcccattc aatggtttcg tggagccggt      240

ccggcgcgtg ttcttatcta caatcaacgc cagggaccct tcccgcgtgt tacaacgatc      300

agtgaaacta cccgtcgtga aaacatggac tttagcattt cgatctccaa cattacaccc      360

gctgacgcag ggacgtacta ctgcatcaag tttcgtaaag gatctccaga cactgagttt      420

aagtctggcg cagggacgga gttgtccgtg cgtgcgaaac cttctggcgg aggagggtcg      480

gggggcggtg gttctgaaga ggaagttcag attatccaac cagataaatc agtgtccgtg      540

gcggcgggag agtcagctat ccttcactgt acaatcacat cgttattccc tgtagggcca      600

attcagtggt tccgtggggc aggacccgca cgtgtcctta tctataatca gcgtcagggg      660

cccttcccac gtgttacgac aatttcagag actactcgcc gcgagaacat ggacttcagt      720

attagcatct cgaacattac cccggcggac gcgggaactt attactgtat caagtttcgt      780

aaaggctcgc cggacaccga gttcaaatcc ggggcaggca ctgagttgag cgtgcgtgcg      840

aaaccatcgg gcagcggcga gctcggtggc agtggtaagc ctatccctaa ccctctcctc      900

ggcctcgatt ctacgggatc cggtcatcat caccatcacc attga                      945


<210> 1098
<211> 1224
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1098
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcac aattgggtgg tagcgaggag gagttacaaa ttatccaacc agataagtct      120

gtcttggtcg cagccggaga aacggcgacg ttacgctgca caatcacctc actgttcccg      180

gtcggtccga ttcagtggtt ccgtggagct ggtccgggcc gtgtcttaat ttacaatcaa      240

cgtcaaggac cttttccacg cgtaacaact gtttctgaca caaccaaacg taacaatatg      300

gacttttcta ttcgtattgg caacattacg ccagccgatg caggtacata ctactgtatc      360

aaattccgta aaggtagtcc tgatgacgtt gagtttaaaa gcggcgcagg gacggagctt      420

tcagtgcgtg caaagcccag tgctagcgcg gcggcgccgc catgcccgcc atgccctgcg      480

cccgagttct tgggtgggcc ttcagtgttc ctttttcccc cgaaaccaaa agataccctg      540

atgatttcgc gcacccctga agttacttgt gtggttgttg acgtctcaca agaggaccca      600

gaggtacaat tcaactggta tgtggacgga gtagaggtgc ataacgccaa gactaagccc      660

cgtgaagagc agttcaattc tacataccgt gtagtttcgg ttttaacggt cttacaccaa      720

gattggttga acggaaagga atataagtgc aaggtgtcca ataagggact gccaagcagt      780

atcgaaaaaa caatctcaaa agcaaaggga caaccgcgtg agccccaggt ttacactctg      840

ccaccgtcgc aagaggagat gacgaagaat caggtgtcgt taacctgttt ggtcaaaggc      900

ttttatccaa gcgatatcgc agtggaatgg gaatcaaatg ggcagcctga aaataactat      960

aagacaaccc cgcctgtact tgattctgat ggatcttttt ttctttatag tcgcttaacc     1020

gtggataaat cccgttggca ggaaggtaat gtcttctcat gctcggttat gcacgaggcc     1080

cttcataacc attacactca gaagagcctt tctctgagtc cggggaaagg cagcggcgag     1140

ctcggtggca gtggtaagcc tatccctaac cctctcctcg gcctcgattc tacgggatcc     1200

ggtcatcatc accatcacca ttga                                            1224


<210> 1099
<211> 1128
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1099
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcac aattgggtgg tagcgaggag gagttacaaa ttatccaacc agataagtct      120

gtcttggtcg cagccggaga aacggcgacg ttacgctgca caatcacctc actgttcccg      180

gtcggtccga ttcagtggtt ccgtggagct ggtccgggcc gtgtcttaat ttacaatcaa      240

cgtcaaggac cttttccacg cgtaacaact gtttctgaca caaccaaacg taacaatatg      300

gacttttcta ttcgtattgg caacattacg ccagccgatg caggtacata ctactgtatc      360

aaattccgta aaggtagtcc tgatgacgtt gagtttaaaa gcggcgcagg gacggagctt      420

tcagtgcgtg caaagcccag tgctagcgcg gcggcgccgc catgcccgcc atgccctgcg      480

cccgagttct tgggtgggcc ttcagtgttc ctttttcccc cgaaaccaaa agataccctg      540

atgatttcgc gcacccctga agttacttgt gtggttgttg acgtctcaca agaggaccca      600

gaggtacaat tcaactggta tgtggacgga gtagaggtgc ataacgccaa gactaagccc      660

cgtgaagagc agttcaattc tacataccgt gtagtttcgg ttttaacggt cttacaccaa      720

gattggttga acggaaagga atataagtgc aaggtgtcca ataagggact gccaagcagt      780

atcgaaaaaa caatctcaaa agcaaaggga caaccgcgtg agccccaggt ttacactctg      840

ccaccgtcgc aagaggagat gacgaagaat caggtgtcgt taacctgttt ggtcaaaggc      900

ttttatccaa gcgatatcgc agtggaatgg gaatcaaatg ggcagcctga aaataactat      960

aagacaaccc cgcctgtact tgattctgat ggatcttttt ttctttatag tcgcttaacc     1020

gtggataaat cccgttggca ggaaggtaat gtcttctcat gctcggttat gcacgaggcc     1080

cttcataacc attacactca gaagagcctt tctctgagtc cggggaaa                  1128


<210> 1100
<211> 1128
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1100
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcac aattgggtgg tagcgaggag gagttacaaa ttatccaacc agataagtct      120

gtcttggtcg cagccggaga aacggcgacg ttacgctgca caatcacctc actgttcccg      180

gtcggtccga ttcagtggtt ccgtggagct ggtccgggcc gtgtcttaat ttacaatcaa      240

cgtcaaggac cttttccacg cgtaacaact gtttctgaca caaccaaacg taacaatatg      300

gacttttcta ttcgtattgg caacattacg ccagccgatg caggtacata ctactgtatc      360

aaattccgta aaggtagtcc tgatgacgtt gagtttaaaa gcggcgcagg gacggagctt      420

tcagtgcgtg caaagcccag tgctagcgcg gcggcgccgc catgcccgcc atgccctgcg      480

cccgagttct tgggtgggcc ttcagtgttc ctttttcccc cgaaaccaaa agataccctg      540

atgatttcgc gcacccctga agttacttgt gtggttgttg acgtctcaca agaggaccca      600

gaggtacaat tcaactggta tgtggacgga gtagaggtgc ataacgccaa gactaagccc      660

cgtgaagagc agttcaattc tacataccgt gtagtttcgg ttttaacggt cttacaccaa      720

gattggttga acggaaagga atataagtgc aaggtgtcca ataagggact gccaagcagt      780

atcgaaaaaa caatctcaaa agcaaaggga caaccgcgtg agccccaggt ttacactctg      840

ccaccgtcgc aagaggagat gacgaagaat caggtgtcgt taacctgttt ggtcaaaggc      900

ttttatccaa gcgatatcgc agtggaatgg gaatcaaatg ggcagcctga aaataactat      960

aagacaaccc cgcctgtact tgattctgat ggatcttttt ttctttatag tcgcttaacc     1020

gtggataaat cccgttggca ggaaggtaat gtcttctcat gctcggttat gcacgaggcc     1080

cttcataacc attacactca gaagagcctt tctctgagtc cggggaaa                  1128


<210> 1101
<211> 1191
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1101
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcac aattgggtgg tagcgaagaa gaggtgcaga tcatccaacc cgataaatcg      120

gtatctgtcg cagctgggga gtcggcgatt ttgcattgca ccattacatc tttgttccct      180

gttgggccta ttcaatggtt tcgcggggca ggtccggccc gcgtattgat ttataaccag      240

cgtcaaggac cgttcccccg tgttacaact atttcggaaa caacacgtcg tgaaaatatg      300

gatttctcga tctctatctc taacattact cccgccgatg cagggactta ttattgcatt      360

aaatttcgca aaggaagccc cgacacggag tttaagagtg gagcgggcac ggaattatcg      420

gtgcgcgcga aacccagtgc tagcgcggcg gcgccgccat gcccgccatg ccctgcgccc      480

gagttcttgg gtgggccttc agtgttcctt tttcccccga aaccaaaaga taccctgatg      540

atttcgcgca cccctgaagt tacttgtgtg gttgttgacg tctcacaaga ggacccagag      600

gtacaattca actggtatgt ggacggagta gaggtgcata acgccaagac taagccccgt      660

gaagagcagt tcaattctac ataccgtgta gtttcggttt taacggtctt acaccaagat      720

tggttgaacg gaaaggaata taagtgcaag gtgtccaata agggactgcc aagcagtatc      780

gaaaaaacaa tctcaaaagc aaagggacaa ccgcgtgagc cccaggttta cactctgcca      840

ccgtcgcaag aggagatgac gaagaatcag gtgtcgttaa cctgtttggt caaaggcttt      900

tatccaagcg atatcgcagt ggaatgggaa tcaaatgggc agcctgaaaa taactataag      960

acaaccccgc ctgtacttga ttctgatgga tctttttttc tttatagtcg cttaaccgtg     1020

gataaatccc gttggcagga aggtaatgtc ttctcatgct cggttatgca cgaggccctt     1080

cataaccatt acactcagaa gagcctttct ctgagtccgg ggaaaggcag cggcgagctc     1140

ggtggcagtg gtaagcctat ccctaaccct ctcctcggcc tcgattctac g              1191


<210> 1102
<211> 1041
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1102
gaagaagagg tgcagatcat ccaacccgat aaatcggtat ctgtcgcagc tggggagtcg       60

gcgattttgc attgcaccat tacatctttg ttccctgttg ggcctattca atggtttcgc      120

ggggcaggtc cggcccgcgt attgatttat aaccagcgtc aaggaccgtt cccccgtgtt      180

acaactattt cggaaacaac acgtcgtgaa aatatggatt tctcgatctc tatctctaac      240

attactcccg ccgatgcagg gacttattat tgcattaaat ttcgcaaagg aagccccgac      300

acggagttta agagtggagc gggcacggaa ttatcggtgc gcgcgaaacc cagtgctagc      360

gcggcggcgc cgccatgccc gccatgccct gcgcccgagt tcttgggtgg gccttcagtg      420

ttcctttttc ccccgaaacc aaaagatacc ctgatgattt cgcgcacccc tgaagttact      480

tgtgtggttg ttgacgtctc acaagaggac ccagaggtac aattcaactg gtatgtggac      540

ggagtagagg tgcataacgc caagactaag ccccgtgaag agcagttcaa ttctacatac      600

cgtgtagttt cggttttaac ggtcttacac caagattggt tgaacggaaa ggaatataag      660

tgcaaggtgt ccaataaggg actgccaagc agtatcgaaa aaacaatctc aaaagcaaag      720

ggacaaccgc gtgagcccca ggtttacact ctgccaccgt cgcaagagga gatgacgaag      780

aatcaggtgt cgttaacctg tttggtcaaa ggcttttatc caagcgatat cgcagtggaa      840

tgggaatcaa atgggcagcc tgaaaataac tataagacaa ccccgcctgt acttgattct      900

gatggatctt tttttcttta tagtcgctta accgtggata aatcccgttg gcaggaaggt      960

aatgtcttct catgctcggt tatgcacgag gcccttcata accattacac tcagaagagc     1020

ctttctctga gtccggggaa a                                               1041


<210> 1103
<211> 681
<212> DNA
<213> Homo sapiens

<400> 1103
gcggcggcgc cgccatgccc gccatgccct gcgcccgagt tcttgggtgg gccttcagtg       60

ttcctttttc ccccgaaacc aaaagatacc ctgatgattt cgcgcacccc tgaagttact      120

tgtgtggttg ttgacgtctc acaagaggac ccagaggtac aattcaactg gtatgtggac      180

ggagtagagg tgcataacgc caagactaag ccccgtgaag agcagttcaa ttctacatac      240

cgtgtagttt cggttttaac ggtcttacac caagattggt tgaacggaaa ggaatataag      300

tgcaaggtgt ccaataaggg actgccaagc agtatcgaaa aaacaatctc aaaagcaaag      360

ggacaaccgc gtgagcccca ggtttacact ctgccaccgt cgcaagagga gatgacgaag      420

aatcaggtgt cgttaacctg tttggtcaaa ggcttttatc caagcgatat cgcagtggaa      480

tgggaatcaa atgggcagcc tgaaaataac tataagacaa ccccgcctgt acttgattct      540

gatggatctt tttttcttta tagtcgctta accgtggata aatcccgttg gcaggaaggt      600

aatgtcttct catgctcggt tatgcacgag gcccttcata accattacac tcagaagagc      660

ctttctctga gtccggggaa a                                                681


<210> 1104
<211> 929
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1104
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcac aattgggtgg tagccaggtt aagttgcttc agtccggtgc cgcattagtg      120

aagcctggag caagtgtcaa gatgtcgtgt caggcaagcg ggtacagctt caccgattat      180

tgggtgacgt gggttaaaca atcccacgga caatcattgg aatggatcgg ggaaatctac      240

cccagtaaca ctgtgacaaa ttttaacgac aattttaaag ggaaggcaac ccttacggtg      300

gataagtcta cttccacagc gtatatggag ctgagtcgcc tgacttctga ggactctgcc      360

atctattact gtacacgtat cgggaacagt gggtatcgtg tagggtggtt catctactgg      420

gggcaaggta cccttgtgac agttttatcc gggggtggcg ggtcgggagg ggggggatca      480

ggcggtggag ggtcggatac agttctgacc cagtctccgg cattggcggt gtcaccgggg      540

gagcgtgtca cgatcagttg taaggcatcg gaatccgtgt cgagccacat gcactggtac      600

cagcagaaac cggggcagca gcctaaactg ttgatttaca aggcatcaaa tttagcctct      660

ggtgtacccg ctcgttttag tggcagtggc tcgggaacgg acttcacttt aacgattgac      720

cctgttgagg cagacgatac cgccacttac ttctgccagc agggttggaa cggcccattc      780

acttttgggg ccgggacccg tctggaactg aagcgcgcgg acgccgctgg cagcggcgag      840

ctcggtggca gtggtaagcc tatccctaac cctctcctcg gcctcgattc tacgggatcc      900

ggtcatcacc accatcacca tcaccattg                                        929


<210> 1105
<211> 415
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1105
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly Lys Glu Leu Lys Val Thr Gln Pro Glu Lys Ser 
        35                  40                  45              


Val Ser Val Ala Ala Gly Asp Ser Thr Val Leu Asn Cys Thr Leu Thr 
    50                  55                  60                  


Ser Leu Leu Pro Val Gly Pro Ile Lys Trp Tyr Arg Gly Val Gly Gln 
65                  70                  75                  80  


Ser Arg Leu Leu Ile Tyr Ser Phe Thr Gly Glu His Phe Pro Arg Val 
                85                  90                  95      


Thr Asn Val Ser Asp Ala Thr Lys Arg Asn Asn Met Asp Phe Ser Ile 
            100                 105                 110         


Arg Ile Ser Asn Val Thr Pro Glu Asp Ala Gly Thr Tyr Tyr Cys Val 
        115                 120                 125             


Lys Phe Gln Lys Gly Pro Ser Glu Pro Asp Thr Glu Ile Gln Ser Gly 
    130                 135                 140                 


Gly Gly Thr Glu Val Tyr Val Leu Ala Lys Pro Ser Pro Pro Glu Val 
145                 150                 155                 160 


Ser Gly Pro Ala Asp Arg Gly Ile Pro Asp Gln Lys Val Asn Phe Thr 
                165                 170                 175     


Cys Lys Ser His Gly Phe Ser Pro Arg Asn Ile Thr Leu Lys Trp Phe 
            180                 185                 190         


Lys Asp Gly Gln Glu Leu His His Leu Glu Thr Thr Val Asn Pro Ser 
        195                 200                 205             


Gly Lys Asn Val Ser Tyr Asn Ile Ser Ser Thr Val Arg Val Val Leu 
    210                 215                 220                 


Asn Ser Met Asp Val His Ser Lys Val Ile Cys Glu Val Ala His Ile 
225                 230                 235                 240 


Thr Leu Asp Arg Ser Pro Leu Arg Gly Ile Ala Asn Leu Ser Asn Phe 
                245                 250                 255     


Ile Arg Val Ser Pro Thr Val Lys Val Thr Gln Gln Ser Pro Thr Ser 
            260                 265                 270         


Met Asn Gln Val Asn Leu Thr Cys Arg Ala Glu Arg Phe Tyr Pro Glu 
        275                 280                 285             


Asp Leu Gln Leu Ile Trp Leu Glu Asn Gly Asn Val Ser Arg Asn Asp 
    290                 295                 300                 


Thr Pro Lys Asn Leu Thr Lys Asn Thr Asp Gly Thr Tyr Asn Tyr Thr 
305                 310                 315                 320 


Ser Leu Phe Leu Val Asn Ser Ser Ala His Arg Glu Asp Val Val Phe 
                325                 330                 335     


Thr Cys Gln Val Lys His Asp Gln Gln Pro Ala Ile Thr Arg Asn His 
            340                 345                 350         


Thr Val Leu Gly Leu Ala His Ser Ser Asp Gln Gly Ser Met Gln Thr 
        355                 360                 365             


Phe Pro Gly Asn Asn Ala Thr His Asn Trp Asn Lys Gly Glu Leu Asn 
    370                 375                 380                 


Ser Lys Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
385                 390                 395                 400 


Thr Asp Pro Asn Ser Ser Ser Val Asp His His His His His His 
                405                 410                 415 


<210> 1106
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1106
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Ser Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys 
        35                  40                  45              


Ser Val Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile 
    50                  55                  60                  


Thr Ser Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly 
65                  70                  75                  80  


Pro Gly Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg 
                85                  90                  95      


Val Thr Thr Val Ser Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser 
            100                 105                 110         


Ile Arg Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys 
        115                 120                 125             


Ile Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly 
    130                 135                 140                 


Ala Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Gly Ser Gly Glu 
145                 150                 155                 160 


Leu Gly Gly Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
                165                 170                 175     


Ser Thr Gly Ser Gly His His His His His His 
            180                 185         


<210> 1107
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1107
Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser 
        115                 


<210> 1108
<211> 314
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1108
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Ser Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys 
        35                  40                  45              


Ser Val Ser Val Ala Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile 
    50                  55                  60                  


Thr Ser Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly 
65                  70                  75                  80  


Pro Ala Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg 
                85                  90                  95      


Val Thr Thr Ile Ser Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser 
            100                 105                 110         


Ile Ser Ile Ser Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys 
        115                 120                 125             


Ile Lys Phe Arg Lys Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala 
    130                 135                 140                 


Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys 
                165                 170                 175     


Ser Val Ser Val Ala Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile 
            180                 185                 190         


Thr Ser Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly 
        195                 200                 205             


Pro Ala Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg 
    210                 215                 220                 


Val Thr Thr Ile Ser Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser 
225                 230                 235                 240 


Ile Ser Ile Ser Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys 
                245                 250                 255     


Ile Lys Phe Arg Lys Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala 
            260                 265                 270         


Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Gly Ser Gly Glu Leu 
        275                 280                 285             


Gly Gly Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
    290                 295                 300                 


Thr Gly Ser Gly His His His His His His 
305                 310                 


<210> 1109
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1109
Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser 
    50                  55                  60                  


Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
    130                 135                 140                 


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro 
145                 150                 155                 160 


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu 
                165                 170                 175     


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser 
            180                 185                 190         


Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
        195                 200                 205             


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
    210                 215                 220                 


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
225                 230                 235                 240 


Val Arg Ala Lys Pro Ser 
                245     


<210> 1110
<211> 416
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1110
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Ser Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys 
        35                  40                  45              


Ser Val Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile 
    50                  55                  60                  


Thr Ser Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly 
65                  70                  75                  80  


Pro Gly Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg 
                85                  90                  95      


Val Thr Thr Val Ser Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser 
            100                 105                 110         


Ile Arg Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys 
        115                 120                 125             


Ile Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly 
    130                 135                 140                 


Ala Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Ser Ala Ala 
145                 150                 155                 160 


Ala Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                165                 170                 175     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            180                 185                 190         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        195                 200                 205             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    210                 215                 220                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
225                 230                 235                 240 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                245                 250                 255     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            260                 265                 270         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        275                 280                 285             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    290                 295                 300                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
305                 310                 315                 320 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                325                 330                 335     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            340                 345                 350         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        355                 360                 365             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380                 


Lys Gly Ser Gly Glu Leu Gly Gly Ser Gly Lys Pro Ile Pro Asn Pro 
385                 390                 395                 400 


Leu Leu Gly Leu Asp Ser Thr Gly Ser Gly His His His His His His 
                405                 410                 415     


<210> 1111
<211> 385
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1111
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Ser Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys 
        35                  40                  45              


Ser Val Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile 
    50                  55                  60                  


Thr Ser Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly 
65                  70                  75                  80  


Pro Gly Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg 
                85                  90                  95      


Val Thr Thr Val Ser Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser 
            100                 105                 110         


Ile Arg Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys 
        115                 120                 125             


Ile Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly 
    130                 135                 140                 


Ala Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Ser Ala Ala 
145                 150                 155                 160 


Ala Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                165                 170                 175     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            180                 185                 190         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        195                 200                 205             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    210                 215                 220                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
225                 230                 235                 240 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                245                 250                 255     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            260                 265                 270         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        275                 280                 285             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    290                 295                 300                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
305                 310                 315                 320 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                325                 330                 335     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            340                 345                 350         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        355                 360                 365             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380                 


Lys 
385 


<210> 1112
<211> 348
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1112
Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Ser Ala Ala Ala Pro Pro Cys Pro 
        115                 120                 125             


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
    130                 135                 140                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
145                 150                 155                 160 


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
                165                 170                 175     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            180                 185                 190         


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        195                 200                 205             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    210                 215                 220                 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
225                 230                 235                 240 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
                245                 250                 255     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            260                 265                 270         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        275                 280                 285             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    290                 295                 300                 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
305                 310                 315                 320 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                325                 330                 335     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345             


<210> 1113
<211> 407
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1113
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Gln Leu Gly Gly Ser Glu Glu Glu Val 
            20                  25                  30          


Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala Ala Gly Glu Ser 
        35                  40                  45              


Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro Val Gly Pro Ile 
    50                  55                  60                  


Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser Glu Thr Thr Arg 
                85                  90                  95      


Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro Ala 
            100                 105                 110         


Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys Gly Ser Pro Asp 
        115                 120                 125             


Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg Ala Lys 
    130                 135                 140                 


Pro Ser Ala Ser Ala Ala Ala Pro Pro Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    210                 215                 220                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                245                 250                 255     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                325                 330                 335     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Glu Leu Gly Gly Ser Gly 
    370                 375                 380                 


Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser 
385                 390                 395                 400 


Gly His His His His His His 
                405         


<210> 1114
<211> 375
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1114
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Gln Leu Gly Gly Ser Glu Glu Glu Val 
            20                  25                  30          


Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala Ala Gly Glu Ser 
        35                  40                  45              


Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro Val Gly Pro Ile 
    50                  55                  60                  


Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser Glu Thr Thr Arg 
                85                  90                  95      


Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro Ala 
            100                 105                 110         


Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys Gly Ser Pro Asp 
        115                 120                 125             


Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg Ala Lys 
    130                 135                 140                 


Pro Ser Ala Ser Ala Ala Ala Pro Pro Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    210                 215                 220                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                245                 250                 255     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                325                 330                 335     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly Lys 
    370                 375 


<210> 1115
<211> 347
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1115
Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser 
    50                  55                  60                  


Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Ala Ser Ala Ala Ala Pro Pro Cys Pro Pro 
        115                 120                 125             


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    130                 135                 140                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
145                 150                 155                 160 


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                165                 170                 175     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            180                 185                 190         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        195                 200                 205             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    210                 215                 220                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
225                 230                 235                 240 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                245                 250                 255     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            260                 265                 270         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        275                 280                 285             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    290                 295                 300                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
305                 310                 315                 320 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                325                 330                 335     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345         


<210> 1116
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1116
Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser 
    50                  55                  60                  


Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser 
        115             


<210> 1117
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1117
Ala Ala Ala Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        35                  40                  45              


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 1118
<211> 307
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1118
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Gln Leu Gly Gly Ser Gln Val Lys Leu 
            20                  25                  30          


Leu Gln Ser Gly Ala Ala Leu Val Lys Pro Gly Ala Ser Val Lys Met 
        35                  40                  45              


Ser Cys Gln Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Trp Val Thr Trp 
    50                  55                  60                  


Val Lys Gln Ser His Gly Gln Ser Leu Glu Trp Ile Gly Glu Ile Tyr 
65                  70                  75                  80  


Pro Ser Asn Thr Val Thr Asn Phe Asn Asp Asn Phe Lys Gly Lys Ala 
                85                  90                  95      


Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
            100                 105                 110         


Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Thr Arg Ile Gly 
        115                 120                 125             


Asn Ser Gly Tyr Arg Val Gly Trp Phe Ile Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Asp Thr Val Leu Thr Gln Ser Pro Ala Leu Ala 
                165                 170                 175     


Val Ser Pro Gly Glu Arg Val Thr Ile Ser Cys Lys Ala Ser Glu Ser 
            180                 185                 190         


Val Ser Ser His Met His Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro 
        195                 200                 205             


Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu Ala Ser Gly Val Pro Ala 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
225                 230                 235                 240 


Pro Val Glu Ala Asp Asp Thr Ala Thr Tyr Phe Cys Gln Gln Gly Trp 
                245                 250                 255     


Asn Gly Pro Phe Thr Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys Arg 
            260                 265                 270         


Ala Asp Ala Ala Gly Ser Gly Glu Leu Gly Gly Ser Gly Lys Pro Ile 
        275                 280                 285             


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser Gly His His His 
    290                 295                 300                 


His His His 
305         


<210> 1119
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1119
Ile Val Val Gly Val Val Cys Thr Leu Leu Val Ala Leu Leu Met Ala 
1               5                   10                  15      


Ala Leu Tyr Leu Val 
            20      


<210> 1120
<211> 110
<212> PRT
<213> Homo sapiens

<400> 1120
Arg Ile Arg Gln Lys Lys Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu 
1               5                   10                  15      


His Glu Pro Glu Lys Asn Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp 
            20                  25                  30          


Ile Thr Tyr Ala Asp Leu Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro 
        35                  40                  45              


Gln Ala Ala Glu Pro Asn Asn His Thr Glu Tyr Ala Ser Ile Gln Thr 
    50                  55                  60                  


Ser Pro Gln Pro Ala Ser Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp 
65                  70                  75                  80  


Met Val His Leu Asn Arg Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu 
                85                  90                  95      


Pro Ser Phe Ser Glu Tyr Ala Ser Val Gln Val Pro Arg Lys 
            100                 105                 110 


<210> 1121
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1121
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 1122
<211> 1452
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1122
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggcggtgg ctttcgtggg      120

ccattgttac ccaaccgtcc attcaccact gtctggaacg ccaatacaca atggtgtttg      180

gagcgtcatg gagtcgatgt agatgtatcc gtgtttgatg tcgtggcgaa cccgggacag      240

acatttcgtg gaccggacat gaccatcttt tattcgtcac aacttggcac ctacccttat      300

tacactccca cgggtgagcc tgtctttggt ggacttcctc aaaatgcttc tttgattgcg      360

cacttggcgc gtactttcca agatatcctg gctgccatcc ctgccccgga tttttcggga      420

ctggctgtaa ttgattggga ggcatggcgc cctcgttggg ccttcaactg ggatacaaag      480

gacatttacc gccaacgcag ccgcgccttg gttcaggccc aacaccccga ctggccggcg      540

ccccaggtgg aagcagttgc acaggaccag ttccaaggag ccgctcgcgc ttggatggcg      600

ggtactttac agttggggcg cgctttgcgt cctcgcggct tgtggggatt ctatggtttt      660

ccagactgct ataactacga cttcttgtct cccaactaca ccggacagtg tccctctggg      720

attcgtgctc agaatgacca acttggatgg ctgtggggcc aaagtcgtgc gctgtatccg      780

agcatttata tgccagccgt tctggaagga acaggcaagt ctcagatgta cgttcaacat      840

cgtgtagcgg aagcctttcg tgtagccgtg gcggcaggtg acccaaattt gccggtctta      900

ccttacgtac agatttttta tgacactaca aatcacttcc ttccactgga tgagttagaa      960

cattcattgg gggagtcagc agctcagggc gcggctgggg tggtgttgtg ggtgagctgg     1020

gaaaacacgc gtacgaaaga gtcatgccag gctatcaagg aatacatgga tacaactctt     1080

ggtccgttta ttttgaatgt gacttctggg gcgcttttgt gttcccaggc tctttgctca     1140

ggtcatgggc gttgcgttcg ccgtacctcg catccgaaag cgcttctgct tctgaaccca     1200

gcgtcattca gcattcaact gacacctgga gggggtcctt tatcactgcg cggggcttta     1260

tctttggaag accaagctca gatggcggtc gagttcaagt gtcgctgcta cccaggttgg     1320

caggccccgt ggtgcgagcg taaaagtatg tggaagggcg agctcaattc gaagcttgaa     1380

ggtaagccta tccctaaccc tctcctcggc ctcgattcta cgcgtaccgg tcatcatcac     1440

catcaccatt ga                                                         1452


<210> 1123
<211> 1353
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1123
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggcggtgg ctttcgtggg      120

ccattgttac ccaaccgtcc attcaccact gtctggaacg ccaatacaca atggtgtttg      180

gagcgtcatg gagtcgatgt agatgtatcc gtgtttgatg tcgtggcgaa cccgggacag      240

acatttcgtg gaccggacat gaccatcttt tattcgtcac aacttggcac ctacccttat      300

tacactccca cgggtgagcc tgtctttggt ggacttcctc aaaatgcttc tttgattgcg      360

cacttggcgc gtactttcca agatatcctg gctgccatcc ctgccccgga tttttcggga      420

ctggctgtaa ttgattggga ggcatggcgc cctcgttggg ccttcaactg ggatacaaag      480

gacatttacc gccaacgcag ccgcgccttg gttcaggccc aacaccccga ctggccggcg      540

ccccaggtgg aagcagttgc acaggaccag ttccaaggag ccgctcgcgc ttggatggcg      600

ggtactttac agttggggcg cgctttgcgt cctcgcggct tgtggggatt ctatggtttt      660

ccagactgct ataactacga cttcttgtct cccaactaca ccggacagtg tccctctggg      720

attcgtgctc agaatgacca acttggatgg ctgtggggcc aaagtcgtgc gctgtatccg      780

agcatttata tgccagccgt tctggaagga acaggcaagt ctcagatgta cgttcaacat      840

cgtgtagcgg aagcctttcg tgtagccgtg gcggcaggtg acccaaattt gccggtctta      900

ccttacgtac agatttttta tgacactaca aatcacttcc ttccactgga tgagttagaa      960

cattcattgg gggagtcagc agctcagggc gcggctgggg tggtgttgtg ggtgagctgg     1020

gaaaacacgc gtacgaaaga gtcatgccag gctatcaagg aatacatgga tacaactctt     1080

ggtccgttta ttttgaatgt gacttctggg gcgcttttgt gttcccaggc tctttgctca     1140

ggtcatgggc gttgcgttcg ccgtacctcg catccgaaag cgcttctgct tctgaaccca     1200

gcgtcattca gcattcaact gacacctgga gggggtcctt tatcactgcg cggggcttta     1260

tctttggaag accaagctca gatggcggtc gagttcaagt gtcgctgcta cccaggttgg     1320

caggccccgt ggtgcgagcg taaaagtatg tgg                                  1353


<210> 1124
<211> 1440
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1124
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggcggtgg ctctgttgtt      120

agcaaccgtc cctttatcac tgtgtggaac ggtgacacac attggtgttt aaccgagtac      180

ggggtcgatg tggacgtttc ggtctttgac gtcgtggcta ataaagagca atctttccaa      240

ggctctaata tgaccatctt ctatcgtgaa gagcttggca catacccata ctacacccca      300

actggcgagc cagtctttgg ggggcttccg caaaatgcct ctttggtgac tcatctggcg      360

cataccttcc aagatatcaa agcggcgatg cccgaaccag atttttccgg gttagcggta      420

atcgactggg aggcatggcg tcctcgctgg gcttttaact gggatagtaa agatatttat      480

cgccaacgtt ctatggaact tgtgcaagca gaacatcctg attggcctga gaccctggtg      540

gaggcagctg ctaaaaatca gttccaggag gcagcagaag cgtggatggc cggaacgctg      600

cagttggggc aagtgttgcg cccgcgcgga ctttggggct attatggatt ccccgactgt      660

tataacaatg acttcctttc gttaaattac accggccaat gtcccgtgtt cgttcgtgat      720

cagaatgatc agttgggatg gttgtggaac cagtcatacg ccctttatcc atccatctat      780

ttacccgccg ctttaatggg cacggagaaa tctcagatgt atgttcgcca ccgtgttcag      840

gaagcattgc gtgttgctat tgtttcccgt gacccccacg ttccggtcat gccatacgtc      900

caaatctttt acgaaatgac cgactatttg ttaccgttag aagagcttga acacagtttg      960

ggggagtcag ctgcacaagg tgtagcggga gcagtgcttt ggttgagttc agacaaaacg     1020

tctactaaag aatcatgtca agcaattaaa gcatacatgg attccacctt gggtccgttt     1080

atcgtgaacg tcacatcggc ggcattgtta tgctcagaag ccctttgctc ggggcatggc     1140

cgctgtgttc gtcatccaag ctaccccgag gctctgttga cattgaatcc tgcaagtttt     1200

tcgatcgaac tgacacatga cgggcgccca cccagtctta aaggcaccct ttcattgaaa     1260

gatcgtgctc agatggcgat gaaattccgc tgtcgttgct atcgtggttg gcgcggcaag     1320

tggtgcgata aacgtggtat gaagggcgag ctcaattcga agcttgaagg taagcctatc     1380

cctaaccctc tcctcggcct cgattctacg cgtaccggtc atcatcacca tcaccattga     1440


<210> 1125
<211> 1580
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1125
atgaaacaat cgaccatcgc attggcgctg cttcctctat tgttcacacc ggtgacaaag       60

gcacaattgg gcggtggcat gaaagagatt gctgttacca tcgacgataa aaacgtgatt      120

gcttcagtca gtgaaagctt tcacggcgtc gctttcgacg cttccctgtt ttctccgaaa      180

ggcctgtgga gttttgttga cattacgtca cccaagctgt ttaaactgct tgagggcctg      240

tctccaggtt actttcgcgt tggcgggaca ttcgcgaact ggttattctt cgacttagac      300

gagaacaaca agtggaagga ttactgggct tttaaagaca aaactcctga gacagccaca      360

attacgcgcc gttggttgtt tcgcaagcaa aacaatttaa agaaggagac gttcgatgat      420

cttgtcaagc tgactaaagg atcaaagatg cgtcttttgt ttgacctgaa tgcagaagtt      480

cgcacagggt acgaaattgg caaaaagatg accagcactt gggattcatc tgaagctgaa      540

aagctgttca agtactgtgt tagcaagggt tacggagaca atattgactg ggagcttggt      600

aacgaacccg accacacaag cgcacataac ttaactgaga agcaggtggg tgaagatttc      660

aaggcgctgc ataaagtttt ggagaagtat ccaaccttaa ataaaggatc gttggtaggg      720

cctgacgtag ggtggatggg ggtatcatac gttaaaggtc tggccgatgg tgcaggtgac      780

catgtgacag cttttacgtt acatcaatac tacttcgatg gtaacacgtc ggatgtgtca      840

acttacttgg acgctaccta ctttaaaaag ttacaacagc tgttcgataa ggtaaaagac      900

gtcttgaaaa attccccaca taaagacaaa cccctttggc ttggcgaaac tagctcgggt      960

tacaacagcg gaacgaaaga tgtgtctgac cgttatgtgt cagggttctt gacacttgat     1020

aaattgggcc ttagcgccgc taacaacgtg aaggtcgtca ttcgccagac tatctataat     1080

ggttactatg gcttgttaga caaaaacacc cttgagccta acccggacta ttggttgatg     1140

catgtacata actcgctggt agggaacact gtgttcaagg ttgacgtgtc tgatcctact     1200

aacaaggccc gtgtttacgc gcagtgtacc aaaactaata gcaaacatac acaatctcgc     1260

tactacaaag gttcccttac catttttgct ttgaatgtcg gcgacgagga tgtgacctta     1320

aagattgacc aatattctgg gaagaaaatt tattcatata ttctgactcc agaggggggt     1380

caactgacca gccaaaaagt acttttgaat ggcaaggagt tgaaactggt gagcgatcag     1440

cttccagagc tgaacgcgga tgagtccaaa acatcattta cattatctcc taagacgttc     1500

gggtttttcg tcgtgagtga cgctaatgta gaagcatgta agaaaggatc cggtcatcac     1560

caccatcacc atcaccatta                                                 1580


<210> 1126
<211> 1545
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1126
atgaaacaat cgaccatcgc attggcgctg cttcctctat tgttcacacc ggtgacaaag       60

gcacaattgg gcggtggcat gaaagagatt gctgttacca tcgacgataa aaacgtgatt      120

gcttcagtca gtgaaagctt tcacggcgtc gctttcgacg cttccctgtt ttctccgaaa      180

ggcctgtgga gttttgttga cattacgtca cccaagctgt ttaaactgct tgagggcctg      240

tctccaggtt actttcgcgt tggcgggaca ttcgcgaact ggttattctt cgacttagac      300

gagaacaaca agtggaagga ttactgggct tttaaagaca aaactcctga gacagccaca      360

attacgcgcc gttggttgtt tcgcaagcaa aacaatttaa agaaggagac gttcgatgat      420

cttgtcaagc tgactaaagg atcaaagatg cgtcttttgt ttgacctgaa tgcagaagtt      480

cgcacagggt acgaaattgg caaaaagatg accagcactt gggattcatc tgaagctgaa      540

aagctgttca agtactgtgt tagcaagggt tacggagaca atattgactg ggagcttggt      600

aacgaacccg accacacaag cgcacataac ttaactgaga agcaggtggg tgaagatttc      660

aaggcgctgc ataaagtttt ggagaagtat ccaaccttaa ataaaggatc gttggtaggg      720

cctgacgtag ggtggatggg ggtatcatac gttaaaggtc tggccgatgg tgcaggtgac      780

catgtgacag cttttacgtt acatcaatac tacttcgatg gtaacacgtc ggatgtgtca      840

acttacttgg acgctaccta ctttaaaaag ttacaacagc tgttcgataa ggtaaaagac      900

gtcttgaaaa attccccaca taaagacaaa cccctttggc ttggcgaaac tagctcgggt      960

tacaacagcg gaacgaaaga tgtgtctgac cgttatgtgt cagggttctt gacacttgat     1020

aaattgggcc ttagcgccgc taacaacgtg aaggtcgtca ttcgccagac tatctataat     1080

ggttactatg gcttgttaga caaaaacacc cttgagccta acccggacta ttggttgatg     1140

catgtacata actcgctggt agggaacact gtgttcaagg ttgacgtgtc tgatcctact     1200

aacaaggccc gtgtttacgc gcagtgtacc aaaactaata gcaaacatac acaatctcgc     1260

tactacaaag gttcccttac catttttgct ttgaatgtcg gcgacgagga tgtgacctta     1320

aagattgacc aatattctgg gaagaaaatt tattcatata ttctgactcc agaggggggt     1380

caactgacca gccaaaaagt acttttgaat ggcaaggagt tgaaactggt gagcgatcag     1440

cttccagagc tgaacgcgga tgagtccaaa acatcattta cattatctcc taagacgttc     1500

gggtttttcg tcgtgagtga cgctaatgta gaagcatgta agaaa                     1545


<210> 1127
<211> 483
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1127
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
        35                  40                  45              


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
    50                  55                  60                  


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
65                  70                  75                  80  


Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
                85                  90                  95      


Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu 
            100                 105                 110         


Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp 
        115                 120                 125             


Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile 
    130                 135                 140                 


Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys 
145                 150                 155                 160 


Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro 
                165                 170                 175     


Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln 
            180                 185                 190         


Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala 
        195                 200                 205             


Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr 
    210                 215                 220                 


Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly 
225                 230                 235                 240 


Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg 
                245                 250                 255     


Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly 
            260                 265                 270         


Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val 
        275                 280                 285             


Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln 
    290                 295                 300                 


Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu 
305                 310                 315                 320 


His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu 
                325                 330                 335     


Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile 
            340                 345                 350         


Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr 
        355                 360                 365             


Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg 
    370                 375                 380                 


Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro 
385                 390                 395                 400 


Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu 
                405                 410                 415     


Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe 
            420                 425                 430         


Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys 
        435                 440                 445             


Ser Met Trp Lys Gly Glu Leu Asn Ser Lys Leu Glu Gly Lys Pro Ile 
    450                 455                 460                 


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His His His 
465                 470                 475                 480 


His His His 
            


<210> 1128
<211> 414
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1128
Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe Thr Thr Val Trp Asn 
1               5                   10                  15      


Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly Val Asp Val Asp Val 
            20                  25                  30          


Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln Thr Phe Arg Gly Pro 
        35                  40                  45              


Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly Thr Tyr Pro Tyr Tyr 
    50                  55                  60                  


Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu Pro Gln Asn Ala Ser 
65                  70                  75                  80  


Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp Ile Leu Ala Ala Ile 
                85                  90                  95      


Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile Asp Trp Glu Ala Trp 
            100                 105                 110         


Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys Asp Ile Tyr Arg Gln 
        115                 120                 125             


Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro Asp Trp Pro Ala Pro 
    130                 135                 140                 


Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln Gly Ala Ala Arg Ala 
145                 150                 155                 160 


Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala Leu Arg Pro Arg Gly 
                165                 170                 175     


Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr Asn Tyr Asp Phe Leu 
            180                 185                 190         


Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly Ile Arg Ala Gln Asn 
        195                 200                 205             


Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg Ala Leu Tyr Pro Ser 
    210                 215                 220                 


Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly Lys Ser Gln Met Tyr 
225                 230                 235                 240 


Val Gln His Arg Val Ala Glu Ala Phe Arg Val Ala Val Ala Ala Gly 
                245                 250                 255     


Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln Ile Phe Tyr Asp Thr 
            260                 265                 270         


Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu His Ser Leu Gly Glu 
        275                 280                 285             


Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu Trp Val Ser Trp Glu 
    290                 295                 300                 


Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile Lys Glu Tyr Met Asp 
305                 310                 315                 320 


Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr Ser Gly Ala Leu Leu 
                325                 330                 335     


Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg Cys Val Arg Arg Thr 
            340                 345                 350         


Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro Ala Ser Phe Ser Ile 
        355                 360                 365             


Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu Arg Gly Ala Leu Ser 
    370                 375                 380                 


Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe Lys Cys Arg Cys Tyr 
385                 390                 395                 400 


Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys Ser Met Trp 
                405                 410                 


<210> 1129
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1129
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
        35                  40                  45              


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
    50                  55                  60                  


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
65                  70                  75                  80  


Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
                85                  90                  95      


Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu 
            100                 105                 110         


Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp 
        115                 120                 125             


Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile 
    130                 135                 140                 


Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys 
145                 150                 155                 160 


Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro 
                165                 170                 175     


Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln 
            180                 185                 190         


Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala 
        195                 200                 205             


Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr 
    210                 215                 220                 


Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly 
225                 230                 235                 240 


Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg 
                245                 250                 255     


Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly 
            260                 265                 270         


Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val 
        275                 280                 285             


Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln 
    290                 295                 300                 


Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu 
305                 310                 315                 320 


His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu 
                325                 330                 335     


Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile 
            340                 345                 350         


Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr 
        355                 360                 365             


Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg 
    370                 375                 380                 


Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro 
385                 390                 395                 400 


Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu 
                405                 410                 415     


Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe 
            420                 425                 430         


Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys 
        435                 440                 445             


Ser Met Trp 
    450     


<210> 1130
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1130
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Lys Gln Ser Thr Ile Ala Leu Ala Leu 
            20                  25                  30          


Leu Pro Leu Leu Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp 
        35                  40                  45              


Asp Asp Asp Lys Asp Leu Gly Gly Gly Ser Val Val Ser Asn Arg Pro 
    50                  55                  60                  


Phe Ile Thr Val Trp Asn Gly Asp Thr His Trp Cys Leu Thr Glu Tyr 
65                  70                  75                  80  


Gly Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Lys Glu 
                85                  90                  95      


Gln Ser Phe Gln Gly Ser Asn Met Thr Ile Phe Tyr Arg Glu Glu Leu 
            100                 105                 110         


Gly Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly 
        115                 120                 125             


Leu Pro Gln Asn Ala Ser Leu Val Thr His Leu Ala His Thr Phe Gln 
    130                 135                 140                 


Asp Ile Lys Ala Ala Met Pro Glu Pro Asp Phe Ser Gly Leu Ala Val 
145                 150                 155                 160 


Ile Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Ser 
                165                 170                 175     


Lys Asp Ile Tyr Arg Gln Arg Ser Met Glu Leu Val Gln Ala Glu His 
            180                 185                 190         


Pro Asp Trp Pro Glu Thr Leu Val Glu Ala Ala Ala Lys Asn Gln Phe 
        195                 200                 205             


Gln Glu Ala Ala Glu Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Gln 
    210                 215                 220                 


Val Leu Arg Pro Arg Gly Leu Trp Gly Tyr Tyr Gly Phe Pro Asp Cys 
225                 230                 235                 240 


Tyr Asn Asn Asp Phe Leu Ser Leu Asn Tyr Thr Gly Gln Cys Pro Val 
                245                 250                 255     


Phe Val Arg Asp Gln Asn Asp Gln Leu Gly Trp Leu Trp Asn Gln Ser 
            260                 265                 270         


Tyr Ala Leu Tyr Pro Ser Ile Tyr Leu Pro Ala Ala Leu Met Gly Thr 
        275                 280                 285             


Glu Lys Ser Gln Met Tyr Val Arg His Arg Val Gln Glu Ala Leu Arg 
    290                 295                 300                 


Val Ala Ile Val Ser Arg Asp Pro His Val Pro Val Met Pro Tyr Val 
305                 310                 315                 320 


Gln Ile Phe Tyr Glu Met Thr Asp Tyr Leu Leu Pro Leu Glu Glu Leu 
                325                 330                 335     


Glu His Ser Leu Gly Glu Ser Ala Ala Gln Gly Val Ala Gly Ala Val 
            340                 345                 350         


Leu Trp Leu Ser Ser Asp Lys Thr Ser Thr Lys Glu Ser Cys Gln Ala 
        355                 360                 365             


Ile Lys Ala Tyr Met Asp Ser Thr Leu Gly Pro Phe Ile Val Asn Val 
    370                 375                 380                 


Thr Ser Ala Ala Leu Leu Cys Ser Glu Ala Leu Cys Ser Gly His Gly 
385                 390                 395                 400 


Arg Cys Val Arg His Pro Ser Tyr Pro Glu Ala Leu Leu Thr Leu Asn 
                405                 410                 415     


Pro Ala Ser Phe Ser Ile Glu Leu Thr His Asp Gly Arg Pro Pro Ser 
            420                 425                 430         


Leu Lys Gly Thr Leu Ser Leu Lys Asp Arg Ala Gln Met Ala Met Lys 
        435                 440                 445             


Phe Arg Cys Arg Cys Tyr Arg Gly Trp Arg Gly Lys Trp Cys Asp Lys 
    450                 455                 460                 


Arg Gly Met Lys Gly Glu Leu Asn Ser Lys Leu Glu Gly Lys Pro Ile 
465                 470                 475                 480 


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His His His 
                485                 490                 495     


His His His 
            


<210> 1131
<211> 489
<212> PRT
<213> Hirudo nipponia

<400> 1131
Met Lys Glu Ile Ala Val Thr Ile Asp Asp Lys Asn Val Ile Ala Ser 
1               5                   10                  15      


Val Ser Glu Ser Phe His Gly Val Ala Phe Asp Ala Ser Leu Phe Ser 
            20                  25                  30          


Pro Lys Gly Leu Trp Ser Phe Val Asp Ile Thr Ser Pro Lys Leu Phe 
        35                  40                  45              


Lys Leu Leu Glu Gly Leu Ser Pro Gly Tyr Phe Arg Val Gly Gly Thr 
    50                  55                  60                  


Phe Ala Asn Trp Leu Phe Phe Asp Leu Asp Glu Asn Asn Lys Trp Lys 
65                  70                  75                  80  


Asp Tyr Trp Ala Phe Lys Asp Lys Thr Pro Glu Thr Ala Thr Ile Thr 
                85                  90                  95      


Arg Arg Trp Leu Phe Arg Lys Gln Asn Asn Leu Lys Lys Glu Thr Phe 
            100                 105                 110         


Asp Asp Leu Val Lys Leu Thr Lys Gly Ser Lys Met Arg Leu Leu Phe 
        115                 120                 125             


Asp Leu Asn Ala Glu Val Arg Thr Gly Tyr Glu Ile Gly Lys Lys Met 
    130                 135                 140                 


Thr Ser Thr Trp Asp Ser Ser Glu Ala Glu Lys Leu Phe Lys Tyr Cys 
145                 150                 155                 160 


Val Ser Lys Gly Tyr Gly Asp Asn Ile Asp Trp Glu Leu Gly Asn Glu 
                165                 170                 175     


Pro Asp His Thr Ser Ala His Asn Leu Thr Glu Lys Gln Val Gly Glu 
            180                 185                 190         


Asp Phe Lys Ala Leu His Lys Val Leu Glu Lys Tyr Pro Thr Leu Asn 
        195                 200                 205             


Lys Gly Ser Leu Val Gly Pro Asp Val Gly Trp Met Gly Val Ser Tyr 
    210                 215                 220                 


Val Lys Gly Leu Ala Asp Gly Ala Gly Asp His Val Thr Ala Phe Thr 
225                 230                 235                 240 


Leu His Gln Tyr Tyr Phe Asp Gly Asn Thr Ser Asp Val Ser Thr Tyr 
                245                 250                 255     


Leu Asp Ala Thr Tyr Phe Lys Lys Leu Gln Gln Leu Phe Asp Lys Val 
            260                 265                 270         


Lys Asp Val Leu Lys Asn Ser Pro His Lys Asp Lys Pro Leu Trp Leu 
        275                 280                 285             


Gly Glu Thr Ser Ser Gly Tyr Asn Ser Gly Thr Lys Asp Val Ser Asp 
    290                 295                 300                 


Arg Tyr Val Ser Gly Phe Leu Thr Leu Asp Lys Leu Gly Leu Ser Ala 
305                 310                 315                 320 


Ala Asn Asn Val Lys Val Val Ile Arg Gln Thr Ile Tyr Asn Gly Tyr 
                325                 330                 335     


Tyr Gly Leu Leu Asp Lys Asn Thr Leu Glu Pro Asn Pro Asp Tyr Trp 
            340                 345                 350         


Leu Met His Val His Asn Ser Leu Val Gly Asn Thr Val Phe Lys Val 
        355                 360                 365             


Asp Val Ser Asp Pro Thr Asn Lys Ala Arg Val Tyr Ala Gln Cys Thr 
    370                 375                 380                 


Lys Thr Asn Ser Lys His Thr Gln Ser Arg Tyr Tyr Lys Gly Ser Leu 
385                 390                 395                 400 


Thr Ile Phe Ala Leu Asn Val Gly Asp Glu Asp Val Thr Leu Lys Ile 
                405                 410                 415     


Asp Gln Tyr Ser Gly Lys Lys Ile Tyr Ser Tyr Ile Leu Thr Pro Glu 
            420                 425                 430         


Gly Gly Gln Leu Thr Ser Gln Lys Val Leu Leu Asn Gly Lys Glu Leu 
        435                 440                 445             


Lys Leu Val Ser Asp Gln Leu Pro Glu Leu Asn Ala Asp Glu Ser Lys 
    450                 455                 460                 


Thr Ser Phe Thr Leu Ser Pro Lys Thr Phe Gly Phe Phe Val Val Ser 
465                 470                 475                 480 


Asp Ala Asn Val Glu Ala Cys Lys Lys 
                485                 


<210> 1132
<211> 78
<212> PRT
<213> Homo sapiens

<400> 1132
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
65                  70                  75              


<210> 1133
<211> 248
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1133
Met Phe Lys Ser Thr Leu Ala Ala Met Ala Ala Val Phe Ala Leu Ser 
1               5                   10                  15      


Ala Leu Ser Pro Ala Ala Met Ala Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Ile Glu Gly Arg Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        35                  40                  45              


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    50                  55                  60                  


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
65                  70                  75                  80  


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                85                  90                  95      


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
            100                 105                 110         


Pro Ser Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
    130                 135                 140                 


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
145                 150                 155                 160 


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
                165                 170                 175     


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
            180                 185                 190         


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu 
        195                 200                 205             


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
    210                 215                 220                 


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
225                 230                 235                 240 


Val Gln Met Phe Ile Asn Thr Ser 
                245             


<210> 1134
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1134
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Ser Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90                  95      


Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            100                 105                 110         


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        115                 120                 125             


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    130                 135                 140                 


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
145                 150                 155                 160 


Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly 
                165                 170                 175     


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            180                 185                 190         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        195                 200                 205             


Ile Asn Thr Ser 
    210         


<210> 1135
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1135
Met Phe Lys Ser Thr Leu Ala Ala Met Ala Ala Val Phe Ala Leu Ser 
1               5                   10                  15      


Ala Leu Ser Pro Ala Ala Met Ala 
            20                  


<210> 1136
<211> 114
<212> PRT
<213> Homo sapiens

<400> 1136
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 1137
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1137
Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Leu Gln 
            20  


<210> 1138
<211> 234
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1138
atcacctgcc cgcctccaat gtctgttgag cacgcagata tttgggtaaa atcttactct       60

ttatattccc gtgaacgcta tatctgtaat agtggcttca agcgcaaggc aggcacatcc      120

tcactgacgg agtgtgtttt aaacaaagca acaaacgtcg ctcactggac gacgcccagc      180

ctgaagtgca tccgcgaccc ggcattggtc catcaacgtc cagcccctcc ctca            234


<210> 1139
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1139
atgtttaagt ctacacttgc agccatggcc gcagtcttcg cactgtcagc cttgagtcct       60

gctgcaatgg cagattataa agacgatgac gataagatcg aaggacgtat cacctgcccg      120

cctccaatgt ctgttgagca cgcagatatt tgggtaaaat cttactcttt atattcccgt      180

gaacgctata tctgtaatag tggcttcaag cgcaaggcag gcacatcctc actgacggag      240

tgtgttttaa acaaagcaac aaacgtcgct cactggacga cgcccagcct gaagtgcatc      300

cgcgacccgg cattggtcca tcaacgtcca gcccctccct catccggagg gagcggcggc      360

gggggtagtg gaggcgggtc aggcggcggg ggctcacttc agaactgggt gaatgtcatc      420

tcggacttaa agaagattga agacttgatt cagagcatgc atatcgacgc gactttatac      480

accgagtctg acgtacaccc aagttgcaag gtcaccgcca tgaagtgctt cttgcttgag      540

ttacaagtca tcagtttgga atctggagac gctagtattc acgatacggt ggaaaacctg      600

atcatccttg caaatgactc tctttcatcc aatggtaatg ttactgagtc ggggtgcaaa      660

gaatgtgaag aacttgagga gaagaacatt aaggaatttc ttcagtcatt cgtgcatatc      720

gtacagatgt tcatcaacac ctcttaa                                          747


<210> 1140
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1140
atcacctgcc cgcctccaat gtctgttgag cacgcagata tttgggtaaa atcttactct       60

ttatattccc gtgaacgcta tatctgtaat agtggcttca agcgcaaggc aggcacatcc      120

tcactgacgg agtgtgtttt aaacaaagca acaaacgtcg ctcactggac gacgcccagc      180

ctgaagtgca tccgcgaccc ggcattggtc catcaacgtc cagcccctcc ctcatccgga      240

gggagcggcg gcgggggtag tggaggcggg tcaggcggcg ggggctcact tcagaactgg      300

gtgaatgtca tctcggactt aaagaagatt gaagacttga ttcagagcat gcatatcgac      360

gcgactttat acaccgagtc tgacgtacac ccaagttgca aggtcaccgc catgaagtgc      420

ttcttgcttg agttacaagt catcagtttg gaatctggag acgctagtat tcacgatacg      480

gtggaaaacc tgatcatcct tgcaaatgac tctctttcat ccaatggtaa tgttactgag      540

tcggggtgca aagaatgtga agaacttgag gagaagaaca ttaaggaatt tcttcagtca      600

ttcgtgcata tcgtacagat gttcatcaac acctcttaa                             639


<210> 1141
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1141
atgtttaagt ctacacttgc agccatggcc gcagtcttcg cactgtcagc cttgagtcct       60

gctgcaatgg ca                                                           72


<210> 1142
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1142
atgaagcagg cgcttcgcgt tgcgtttggg ttccttatcc tgtgggcatc cgtacttcac       60

gcc                                                                     63


<210> 1143
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1143
atgcgcgtac tgttattcct tctgttgtct ctttttatgt tgcccgcttt cagt             54


<210> 1144
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1144
atgaagaaga ctgccatcgc tattgccgtc gcccttgcgg gtttcgcaac cgtggcgcaa       60

gca                                                                     63


<210> 1145
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1145
atgaaatatc tgcttccaac ggctgctgct ggcctgttgc ttcttgccgc ccagcctgcg       60

atggct                                                                  66


<210> 1146
<211> 1749
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1146
atgaaaaaga tttggctggc tcttgccggt ttagtcctgg cattcagcgc aagcgcggtc       60

gactataagg atgacgacga caagcaattg ggcggtggca tctgggagct taagaaggac      120

gtgtatgtag tggagttaga ctggtatcca gatgcccccg gagagatggt ggtcttaaca      180

tgtgacactc cagaggagga cgggattacc tggacacttg accagtcaag cgaggtattg      240

ggttctggaa agacgcttac tattcaagtc aaagaatttg gggatgccgg gcagtataca      300

tgtcacaagg gcggcgaagt tctgtcgcac tccttacttt tgttacacaa aaaagaagac      360

ggcatttggt ccacagacat ccttaaggac caaaaggagc cgaagaataa gacgtttctg      420

cgctgtgaag cgaagaacta tagtggtcgc tttacttgct ggtggttgac gaccatttcc      480

actgatttaa ccttttcggt aaagagttct cgcgggagtt ccgacccaca gggcgtgact      540

tgtggcgcag ccacactttc ggcggaacgc gttcgtgggg acaataagga atacgaatat      600

tcggtcgagt gtcaggaaga ttcagcttgc cctgccgctg aggagtcact tccgattgaa      660

gtgatggttg acgccgtgca caaattaaag tatgaaaatt acacgtcatc tttctttatc      720

cgtgacatta ttaagcccga cccgccaaag aatctgcagc ttaaacccct gaagaacagc      780

cgccaggtgg aagtaagctg ggaatatcct gacacctggt ccactccgca ttcgtatttc      840

tcgttgacgt tttgtgttca ggtgcaggga aagagcaagc gcgaaaagaa ggatcgcgtc      900

tttacagaca aaacgtccgc gacggttatt tgtcgtaaga atgctagtat ctctgttcgc      960

gctcaggacc gttattactc atctagttgg tcggagtggg cctcggttcc ctgctctggg     1020

ggtggaggat cgggtggagg tggctcggga ggtggcggct cccgtaattt accggtggct     1080

actcctgacc cagggatgtt cccgtgcttg caccatagcc aaaacttact tcgcgctgtc     1140

agcaacatgc ttcagaaagc acgtcaaacg cttgagtttt acccgtgtac tagcgaagag     1200

atcgatcacg aggacattac caaagacaaa acctccaccg tcgaggcctg ccttccactt     1260

gaactgacga aaaatgagtc atgcttaaat tctcgtgaaa cctccttcat tactaacgga     1320

tcgtgcctgg cctcgcgcaa gacttcgttc atgatggcat tatgcttgtc gtctatttat     1380

gaagacctta aaatgtatca agtggagttc aagacgatga atgcaaaact tcttatggac     1440

ccgaagcgtc aaatcttctt agaccaaaac atgttggccg tgatcgatga actgatgcaa     1500

gccttgaatt ttaattcgga aactgtaccg caaaaatctt ctcttgaaga accggatttc     1560

tataagacca aaattaaact ttgtatttta cttcacgctt tccgcatccg tgcagtaact     1620

atcgaccgcg taatgagtta ccttaacgcc tcgggtggcg agctcggtgg cagtggtaag     1680

cctatcccta accctctcct cggcctcgat tctacgggat ccggtcatca ccaccatcac     1740

catcaccat                                                             1749


<210> 1147
<211> 1755
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1147
atgaaacaga gcacaatcgc tttagccttg ctgcctcttc ttttcacgcc tgtcacgaag       60

gcagtcgact ataaggatga cgacgacaag caattgggcg gtggcatctg ggagcttaag      120

aaggacgtgt atgtagtgga gttagactgg tatccagatg cccccggaga gatggtggtc      180

ttaacatgtg acactccaga ggaggacggg attacctgga cacttgacca gtcaagcgag      240

gtattgggtt ctggaaagac gcttactatt caagtcaaag aatttgggga tgccgggcag      300

tatacatgtc acaagggcgg cgaagttctg tcgcactcct tacttttgtt acacaaaaaa      360

gaagacggca tttggtccac agacatcctt aaggaccaaa aggagccgaa gaataagacg      420

tttctgcgct gtgaagcgaa gaactatagt ggtcgcttta cttgctggtg gttgacgacc      480

atttccactg atttaacctt ttcggtaaag agttctcgcg ggagttccga cccacagggc      540

gtgacttgtg gcgcagccac actttcggcg gaacgcgttc gtggggacaa taaggaatac      600

gaatattcgg tcgagtgtca ggaagattca gcttgccctg ccgctgagga gtcacttccg      660

attgaagtga tggttgacgc cgtgcacaaa ttaaagtatg aaaattacac gtcatctttc      720

tttatccgtg acattattaa gcccgacccg ccaaagaatc tgcagcttaa acccctgaag      780

aacagccgcc aggtggaagt aagctgggaa tatcctgaca cctggtccac tccgcattcg      840

tatttctcgt tgacgttttg tgttcaggtg cagggaaaga gcaagcgcga aaagaaggat      900

cgcgtcttta cagacaaaac gtccgcgacg gttatttgtc gtaagaatgc tagtatctct      960

gttcgcgctc aggaccgtta ttactcatct agttggtcgg agtgggcctc ggttccctgc     1020

tctgggggtg gaggatcggg tggaggtggc tcgggaggtg gcggctcccg taatttaccg     1080

gtggctactc ctgacccagg gatgttcccg tgcttgcacc atagccaaaa cttacttcgc     1140

gctgtcagca acatgcttca gaaagcacgt caaacgcttg agttttaccc gtgtactagc     1200

gaagagatcg atcacgagga cattaccaaa gacaaaacct ccaccgtcga ggcctgcctt     1260

ccacttgaac tgacgaaaaa tgagtcatgc ttaaattctc gtgaaacctc cttcattact     1320

aacggatcgt gcctggcctc gcgcaagact tcgttcatga tggcattatg cttgtcgtct     1380

atttatgaag accttaaaat gtatcaagtg gagttcaaga cgatgaatgc aaaacttctt     1440

atggacccga agcgtcaaat cttcttagac caaaacatgt tggccgtgat cgatgaactg     1500

atgcaagcct tgaattttaa ttcggaaact gtaccgcaaa aatcttctct tgaagaaccg     1560

gatttctata agaccaaaat taaactttgt attttacttc acgctttccg catccgtgca     1620

gtaactatcg accgcgtaat gagttacctt aacgcctcgg gtggcgagct cggtggcagt     1680

ggtaagccta tccctaaccc tctcctcggc ctcgattcta cgggatccgg tcatcaccac     1740

catcaccatc accat                                                      1755


<210> 1148
<211> 1755
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1148
atgaagcagg ctctgcgcgt ggcatttggg ttcctgatct tatgggcgtc cgtcttacac       60

gcagtcgact ataaggatga cgacgacaag caattgggcg gtggcatctg ggagcttaag      120

aaggacgtgt atgtagtgga gttagactgg tatccagatg cccccggaga gatggtggtc      180

ttaacatgtg acactccaga ggaggacggg attacctgga cacttgacca gtcaagcgag      240

gtattgggtt ctggaaagac gcttactatt caagtcaaag aatttgggga tgccgggcag      300

tatacatgtc acaagggcgg cgaagttctg tcgcactcct tacttttgtt acacaaaaaa      360

gaagacggca tttggtccac agacatcctt aaggaccaaa aggagccgaa gaataagacg      420

tttctgcgct gtgaagcgaa gaactatagt ggtcgcttta cttgctggtg gttgacgacc      480

atttccactg atttaacctt ttcggtaaag agttctcgcg ggagttccga cccacagggc      540

gtgacttgtg gcgcagccac actttcggcg gaacgcgttc gtggggacaa taaggaatac      600

gaatattcgg tcgagtgtca ggaagattca gcttgccctg ccgctgagga gtcacttccg      660

attgaagtga tggttgacgc cgtgcacaaa ttaaagtatg aaaattacac gtcatctttc      720

tttatccgtg acattattaa gcccgacccg ccaaagaatc tgcagcttaa acccctgaag      780

aacagccgcc aggtggaagt aagctgggaa tatcctgaca cctggtccac tccgcattcg      840

tatttctcgt tgacgttttg tgttcaggtg cagggaaaga gcaagcgcga aaagaaggat      900

cgcgtcttta cagacaaaac gtccgcgacg gttatttgtc gtaagaatgc tagtatctct      960

gttcgcgctc aggaccgtta ttactcatct agttggtcgg agtgggcctc ggttccctgc     1020

tctgggggtg gaggatcggg tggaggtggc tcgggaggtg gcggctcccg taatttaccg     1080

gtggctactc ctgacccagg gatgttcccg tgcttgcacc atagccaaaa cttacttcgc     1140

gctgtcagca acatgcttca gaaagcacgt caaacgcttg agttttaccc gtgtactagc     1200

gaagagatcg atcacgagga cattaccaaa gacaaaacct ccaccgtcga ggcctgcctt     1260

ccacttgaac tgacgaaaaa tgagtcatgc ttaaattctc gtgaaacctc cttcattact     1320

aacggatcgt gcctggcctc gcgcaagact tcgttcatga tggcattatg cttgtcgtct     1380

atttatgaag accttaaaat gtatcaagtg gagttcaaga cgatgaatgc aaaacttctt     1440

atggacccga agcgtcaaat cttcttagac caaaacatgt tggccgtgat cgatgaactg     1500

atgcaagcct tgaattttaa ttcggaaact gtaccgcaaa aatcttctct tgaagaaccg     1560

gatttctata agaccaaaat taaactttgt attttacttc acgctttccg catccgtgca     1620

gtaactatcg accgcgtaat gagttacctt aacgcctcgg gtggcgagct cggtggcagt     1680

ggtaagccta tccctaaccc tctcctcggc ctcgattcta cgggatccgg tcatcaccac     1740

catcaccatc accat                                                      1755


<210> 1149
<211> 1770
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1149
atgaaaatca agacgggggc acgcattctt gccttgagcg ccttgacaac gatgatgttc       60

agtgcaagtg cattagcggt cgactataag gatgacgacg acaagcaatt gggcggtggc      120

atctgggagc ttaagaagga cgtgtatgta gtggagttag actggtatcc agatgccccc      180

ggagagatgg tggtcttaac atgtgacact ccagaggagg acgggattac ctggacactt      240

gaccagtcaa gcgaggtatt gggttctgga aagacgctta ctattcaagt caaagaattt      300

ggggatgccg ggcagtatac atgtcacaag ggcggcgaag ttctgtcgca ctccttactt      360

ttgttacaca aaaaagaaga cggcatttgg tccacagaca tccttaagga ccaaaaggag      420

ccgaagaata agacgtttct gcgctgtgaa gcgaagaact atagtggtcg ctttacttgc      480

tggtggttga cgaccatttc cactgattta accttttcgg taaagagttc tcgcgggagt      540

tccgacccac agggcgtgac ttgtggcgca gccacacttt cggcggaacg cgttcgtggg      600

gacaataagg aatacgaata ttcggtcgag tgtcaggaag attcagcttg ccctgccgct      660

gaggagtcac ttccgattga agtgatggtt gacgccgtgc acaaattaaa gtatgaaaat      720

tacacgtcat ctttctttat ccgtgacatt attaagcccg acccgccaaa gaatctgcag      780

cttaaacccc tgaagaacag ccgccaggtg gaagtaagct gggaatatcc tgacacctgg      840

tccactccgc attcgtattt ctcgttgacg ttttgtgttc aggtgcaggg aaagagcaag      900

cgcgaaaaga aggatcgcgt ctttacagac aaaacgtccg cgacggttat ttgtcgtaag      960

aatgctagta tctctgttcg cgctcaggac cgttattact catctagttg gtcggagtgg     1020

gcctcggttc cctgctctgg gggtggagga tcgggtggag gtggctcggg aggtggcggc     1080

tcccgtaatt taccggtggc tactcctgac ccagggatgt tcccgtgctt gcaccatagc     1140

caaaacttac ttcgcgctgt cagcaacatg cttcagaaag cacgtcaaac gcttgagttt     1200

tacccgtgta ctagcgaaga gatcgatcac gaggacatta ccaaagacaa aacctccacc     1260

gtcgaggcct gccttccact tgaactgacg aaaaatgagt catgcttaaa ttctcgtgaa     1320

acctccttca ttactaacgg atcgtgcctg gcctcgcgca agacttcgtt catgatggca     1380

ttatgcttgt cgtctattta tgaagacctt aaaatgtatc aagtggagtt caagacgatg     1440

aatgcaaaac ttcttatgga cccgaagcgt caaatcttct tagaccaaaa catgttggcc     1500

gtgatcgatg aactgatgca agccttgaat tttaattcgg aaactgtacc gcaaaaatct     1560

tctcttgaag aaccggattt ctataagacc aaaattaaac tttgtatttt acttcacgct     1620

ttccgcatcc gtgcagtaac tatcgaccgc gtaatgagtt accttaacgc ctcgggtggc     1680

gagctcggtg gcagtggtaa gcctatccct aaccctctcc tcggcctcga ttctacggga     1740

tccggtcatc accaccatca ccatcaccat                                      1770


<210> 1150
<211> 1761
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1150
atgaataaga aagtcttgac attgtcggcg gtcatggcct cgatgttgtt cggggcagca       60

gcccacgcag tcgactataa ggatgacgac gacaagcaat tgggcggtgg catctgggag      120

cttaagaagg acgtgtatgt agtggagtta gactggtatc cagatgcccc cggagagatg      180

gtggtcttaa catgtgacac tccagaggag gacgggatta cctggacact tgaccagtca      240

agcgaggtat tgggttctgg aaagacgctt actattcaag tcaaagaatt tggggatgcc      300

gggcagtata catgtcacaa gggcggcgaa gttctgtcgc actccttact tttgttacac      360

aaaaaagaag acggcatttg gtccacagac atccttaagg accaaaagga gccgaagaat      420

aagacgtttc tgcgctgtga agcgaagaac tatagtggtc gctttacttg ctggtggttg      480

acgaccattt ccactgattt aaccttttcg gtaaagagtt ctcgcgggag ttccgaccca      540

cagggcgtga cttgtggcgc agccacactt tcggcggaac gcgttcgtgg ggacaataag      600

gaatacgaat attcggtcga gtgtcaggaa gattcagctt gccctgccgc tgaggagtca      660

cttccgattg aagtgatggt tgacgccgtg cacaaattaa agtatgaaaa ttacacgtca      720

tctttcttta tccgtgacat tattaagccc gacccgccaa agaatctgca gcttaaaccc      780

ctgaagaaca gccgccaggt ggaagtaagc tgggaatatc ctgacacctg gtccactccg      840

cattcgtatt tctcgttgac gttttgtgtt caggtgcagg gaaagagcaa gcgcgaaaag      900

aaggatcgcg tctttacaga caaaacgtcc gcgacggtta tttgtcgtaa gaatgctagt      960

atctctgttc gcgctcagga ccgttattac tcatctagtt ggtcggagtg ggcctcggtt     1020

ccctgctctg ggggtggagg atcgggtgga ggtggctcgg gaggtggcgg ctcccgtaat     1080

ttaccggtgg ctactcctga cccagggatg ttcccgtgct tgcaccatag ccaaaactta     1140

cttcgcgctg tcagcaacat gcttcagaaa gcacgtcaaa cgcttgagtt ttacccgtgt     1200

actagcgaag agatcgatca cgaggacatt accaaagaca aaacctccac cgtcgaggcc     1260

tgccttccac ttgaactgac gaaaaatgag tcatgcttaa attctcgtga aacctccttc     1320

attactaacg gatcgtgcct ggcctcgcgc aagacttcgt tcatgatggc attatgcttg     1380

tcgtctattt atgaagacct taaaatgtat caagtggagt tcaagacgat gaatgcaaaa     1440

cttcttatgg acccgaagcg tcaaatcttc ttagaccaaa acatgttggc cgtgatcgat     1500

gaactgatgc aagccttgaa ttttaattcg gaaactgtac cgcaaaaatc ttctcttgaa     1560

gaaccggatt tctataagac caaaattaaa ctttgtattt tacttcacgc tttccgcatc     1620

cgtgcagtaa ctatcgaccg cgtaatgagt taccttaacg cctcgggtgg cgagctcggt     1680

ggcagtggta agcctatccc taaccctctc ctcggcctcg attctacggg atccggtcat     1740

caccaccatc accatcacca t                                               1761


<210> 1151
<211> 1758
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1151
atgatgaagc gtaacatctt agccgttatt gtccccgcat tgcttgtggc cgggacggct       60

aacgcagtcg actataagga tgacgacgac aagcaattgg gcggtggcat ctgggagctt      120

aagaaggacg tgtatgtagt ggagttagac tggtatccag atgcccccgg agagatggtg      180

gtcttaacat gtgacactcc agaggaggac gggattacct ggacacttga ccagtcaagc      240

gaggtattgg gttctggaaa gacgcttact attcaagtca aagaatttgg ggatgccggg      300

cagtatacat gtcacaaggg cggcgaagtt ctgtcgcact ccttactttt gttacacaaa      360

aaagaagacg gcatttggtc cacagacatc cttaaggacc aaaaggagcc gaagaataag      420

acgtttctgc gctgtgaagc gaagaactat agtggtcgct ttacttgctg gtggttgacg      480

accatttcca ctgatttaac cttttcggta aagagttctc gcgggagttc cgacccacag      540

ggcgtgactt gtggcgcagc cacactttcg gcggaacgcg ttcgtgggga caataaggaa      600

tacgaatatt cggtcgagtg tcaggaagat tcagcttgcc ctgccgctga ggagtcactt      660

ccgattgaag tgatggttga cgccgtgcac aaattaaagt atgaaaatta cacgtcatct      720

ttctttatcc gtgacattat taagcccgac ccgccaaaga atctgcagct taaacccctg      780

aagaacagcc gccaggtgga agtaagctgg gaatatcctg acacctggtc cactccgcat      840

tcgtatttct cgttgacgtt ttgtgttcag gtgcagggaa agagcaagcg cgaaaagaag      900

gatcgcgtct ttacagacaa aacgtccgcg acggttattt gtcgtaagaa tgctagtatc      960

tctgttcgcg ctcaggaccg ttattactca tctagttggt cggagtgggc ctcggttccc     1020

tgctctgggg gtggaggatc gggtggaggt ggctcgggag gtggcggctc ccgtaattta     1080

ccggtggcta ctcctgaccc agggatgttc ccgtgcttgc accatagcca aaacttactt     1140

cgcgctgtca gcaacatgct tcagaaagca cgtcaaacgc ttgagtttta cccgtgtact     1200

agcgaagaga tcgatcacga ggacattacc aaagacaaaa cctccaccgt cgaggcctgc     1260

cttccacttg aactgacgaa aaatgagtca tgcttaaatt ctcgtgaaac ctccttcatt     1320

actaacggat cgtgcctggc ctcgcgcaag acttcgttca tgatggcatt atgcttgtcg     1380

tctatttatg aagaccttaa aatgtatcaa gtggagttca agacgatgaa tgcaaaactt     1440

cttatggacc cgaagcgtca aatcttctta gaccaaaaca tgttggccgt gatcgatgaa     1500

ctgatgcaag ccttgaattt taattcggaa actgtaccgc aaaaatcttc tcttgaagaa     1560

ccggatttct ataagaccaa aattaaactt tgtattttac ttcacgcttt ccgcatccgt     1620

gcagtaacta tcgaccgcgt aatgagttac cttaacgcct cgggtggcga gctcggtggc     1680

agtggtaagc ctatccctaa ccctctcctc ggcctcgatt ctacgggatc cggtcatcac     1740

caccatcacc atcaccat                                                   1758


<210> 1152
<211> 1755
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1152
atgaagaaga ctgccatcgc tattgccgtc gcccttgcgg gtttcgcaac cgtggcgcaa       60

gcagtcgact ataaggatga cgacgacaag caattgggcg gtggcatctg ggagcttaag      120

aaggacgtgt atgtagtgga gttagactgg tatccagatg cccccggaga gatggtggtc      180

ttaacatgtg acactccaga ggaggacggg attacctgga cacttgacca gtcaagcgag      240

gtattgggtt ctggaaagac gcttactatt caagtcaaag aatttgggga tgccgggcag      300

tatacatgtc acaagggcgg cgaagttctg tcgcactcct tacttttgtt acacaaaaaa      360

gaagacggca tttggtccac agacatcctt aaggaccaaa aggagccgaa gaataagacg      420

tttctgcgct gtgaagcgaa gaactatagt ggtcgcttta cttgctggtg gttgacgacc      480

atttccactg atttaacctt ttcggtaaag agttctcgcg ggagttccga cccacagggc      540

gtgacttgtg gcgcagccac actttcggcg gaacgcgttc gtggggacaa taaggaatac      600

gaatattcgg tcgagtgtca ggaagattca gcttgccctg ccgctgagga gtcacttccg      660

attgaagtga tggttgacgc cgtgcacaaa ttaaagtatg aaaattacac gtcatctttc      720

tttatccgtg acattattaa gcccgacccg ccaaagaatc tgcagcttaa acccctgaag      780

aacagccgcc aggtggaagt aagctgggaa tatcctgaca cctggtccac tccgcattcg      840

tatttctcgt tgacgttttg tgttcaggtg cagggaaaga gcaagcgcga aaagaaggat      900

cgcgtcttta cagacaaaac gtccgcgacg gttatttgtc gtaagaatgc tagtatctct      960

gttcgcgctc aggaccgtta ttactcatct agttggtcgg agtgggcctc ggttccctgc     1020

tctgggggtg gaggatcggg tggaggtggc tcgggaggtg gcggctcccg taatttaccg     1080

gtggctactc ctgacccagg gatgttcccg tgcttgcacc atagccaaaa cttacttcgc     1140

gctgtcagca acatgcttca gaaagcacgt caaacgcttg agttttaccc gtgtactagc     1200

gaagagatcg atcacgagga cattaccaaa gacaaaacct ccaccgtcga ggcctgcctt     1260

ccacttgaac tgacgaaaaa tgagtcatgc ttaaattctc gtgaaacctc cttcattact     1320

aacggatcgt gcctggcctc gcgcaagact tcgttcatga tggcattatg cttgtcgtct     1380

atttatgaag accttaaaat gtatcaagtg gagttcaaga cgatgaatgc aaaacttctt     1440

atggacccga agcgtcaaat cttcttagac caaaacatgt tggccgtgat cgatgaactg     1500

atgcaagcct tgaattttaa ttcggaaact gtaccgcaaa aatcttctct tgaagaaccg     1560

gatttctata agaccaaaat taaactttgt attttacttc acgctttccg catccgtgca     1620

gtaactatcg accgcgtaat gagttacctt aacgcctcgg gtggcgagct cggtggcagt     1680

ggtaagccta tccctaaccc tctcctcggc ctcgattcta cgggatccgg tcatcaccac     1740

catcaccatc accat                                                      1755


<210> 1153
<211> 1746
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1153
atgcgcgtgt tattgttctt gctgctgagc ttgtttatgt taccagcttt cagtgtcgac       60

tataaggatg acgacgacaa gcaattgggc ggtggcatct gggagcttaa gaaggacgtg      120

tatgtagtgg agttagactg gtatccagat gcccccggag agatggtggt cttaacatgt      180

gacactccag aggaggacgg gattacctgg acacttgacc agtcaagcga ggtattgggt      240

tctggaaaga cgcttactat tcaagtcaaa gaatttgggg atgccgggca gtatacatgt      300

cacaagggcg gcgaagttct gtcgcactcc ttacttttgt tacacaaaaa agaagacggc      360

atttggtcca cagacatcct taaggaccaa aaggagccga agaataagac gtttctgcgc      420

tgtgaagcga agaactatag tggtcgcttt acttgctggt ggttgacgac catttccact      480

gatttaacct tttcggtaaa gagttctcgc gggagttccg acccacaggg cgtgacttgt      540

ggcgcagcca cactttcggc ggaacgcgtt cgtggggaca ataaggaata cgaatattcg      600

gtcgagtgtc aggaagattc agcttgccct gccgctgagg agtcacttcc gattgaagtg      660

atggttgacg ccgtgcacaa attaaagtat gaaaattaca cgtcatcttt ctttatccgt      720

gacattatta agcccgaccc gccaaagaat ctgcagctta aacccctgaa gaacagccgc      780

caggtggaag taagctggga atatcctgac acctggtcca ctccgcattc gtatttctcg      840

ttgacgtttt gtgttcaggt gcagggaaag agcaagcgcg aaaagaagga tcgcgtcttt      900

acagacaaaa cgtccgcgac ggttatttgt cgtaagaatg ctagtatctc tgttcgcgct      960

caggaccgtt attactcatc tagttggtcg gagtgggcct cggttccctg ctctgggggt     1020

ggaggatcgg gtggaggtgg ctcgggaggt ggcggctccc gtaatttacc ggtggctact     1080

cctgacccag ggatgttccc gtgcttgcac catagccaaa acttacttcg cgctgtcagc     1140

aacatgcttc agaaagcacg tcaaacgctt gagttttacc cgtgtactag cgaagagatc     1200

gatcacgagg acattaccaa agacaaaacc tccaccgtcg aggcctgcct tccacttgaa     1260

ctgacgaaaa atgagtcatg cttaaattct cgtgaaacct ccttcattac taacggatcg     1320

tgcctggcct cgcgcaagac ttcgttcatg atggcattat gcttgtcgtc tatttatgaa     1380

gaccttaaaa tgtatcaagt ggagttcaag acgatgaatg caaaacttct tatggacccg     1440

aagcgtcaaa tcttcttaga ccaaaacatg ttggccgtga tcgatgaact gatgcaagcc     1500

ttgaatttta attcggaaac tgtaccgcaa aaatcttctc ttgaagaacc ggatttctat     1560

aagaccaaaa ttaaactttg tattttactt cacgctttcc gcatccgtgc agtaactatc     1620

gaccgcgtaa tgagttacct taacgcctcg ggtggcgagc tcggtggcag tggtaagcct     1680

atccctaacc ctctcctcgg cctcgattct acgggatccg gtcatcacca ccatcaccat     1740

caccat                                                                1746


<210> 1154
<211> 1767
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1154
atgatgatta ccttacgcaa gttgcccctt gcggtagccg ttgctgctgg tgtgatgtcc       60

gcgcaagcaa tggctgtcga ctataaggat gacgacgaca agcaattggg cggtggcatc      120

tgggagctta agaaggacgt gtatgtagtg gagttagact ggtatccaga tgcccccgga      180

gagatggtgg tcttaacatg tgacactcca gaggaggacg ggattacctg gacacttgac      240

cagtcaagcg aggtattggg ttctggaaag acgcttacta ttcaagtcaa agaatttggg      300

gatgccgggc agtatacatg tcacaagggc ggcgaagttc tgtcgcactc cttacttttg      360

ttacacaaaa aagaagacgg catttggtcc acagacatcc ttaaggacca aaaggagccg      420

aagaataaga cgtttctgcg ctgtgaagcg aagaactata gtggtcgctt tacttgctgg      480

tggttgacga ccatttccac tgatttaacc ttttcggtaa agagttctcg cgggagttcc      540

gacccacagg gcgtgacttg tggcgcagcc acactttcgg cggaacgcgt tcgtggggac      600

aataaggaat acgaatattc ggtcgagtgt caggaagatt cagcttgccc tgccgctgag      660

gagtcacttc cgattgaagt gatggttgac gccgtgcaca aattaaagta tgaaaattac      720

acgtcatctt tctttatccg tgacattatt aagcccgacc cgccaaagaa tctgcagctt      780

aaacccctga agaacagccg ccaggtggaa gtaagctggg aatatcctga cacctggtcc      840

actccgcatt cgtatttctc gttgacgttt tgtgttcagg tgcagggaaa gagcaagcgc      900

gaaaagaagg atcgcgtctt tacagacaaa acgtccgcga cggttatttg tcgtaagaat      960

gctagtatct ctgttcgcgc tcaggaccgt tattactcat ctagttggtc ggagtgggcc     1020

tcggttccct gctctggggg tggaggatcg ggtggaggtg gctcgggagg tggcggctcc     1080

cgtaatttac cggtggctac tcctgaccca gggatgttcc cgtgcttgca ccatagccaa     1140

aacttacttc gcgctgtcag caacatgctt cagaaagcac gtcaaacgct tgagttttac     1200

ccgtgtacta gcgaagagat cgatcacgag gacattacca aagacaaaac ctccaccgtc     1260

gaggcctgcc ttccacttga actgacgaaa aatgagtcat gcttaaattc tcgtgaaacc     1320

tccttcatta ctaacggatc gtgcctggcc tcgcgcaaga cttcgttcat gatggcatta     1380

tgcttgtcgt ctatttatga agaccttaaa atgtatcaag tggagttcaa gacgatgaat     1440

gcaaaacttc ttatggaccc gaagcgtcaa atcttcttag accaaaacat gttggccgtg     1500

atcgatgaac tgatgcaagc cttgaatttt aattcggaaa ctgtaccgca aaaatcttct     1560

cttgaagaac cggatttcta taagaccaaa attaaacttt gtattttact tcacgctttc     1620

cgcatccgtg cagtaactat cgaccgcgta atgagttacc ttaacgcctc gggtggcgag     1680

ctcggtggca gtggtaagcc tatccctaac cctctcctcg gcctcgattc tacgggatcc     1740

ggtcatcacc accatcacca tcaccat                                         1767


<210> 1155

<400> 1155
000


<210> 1156
<211> 1758
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1156
atgaaatatc ttcttccaac ggctgctgct ggtttattgc ttcttgccgc ccagcctgcg       60

atggctgtcg actataagga tgacgacgac aagcaattgg gcggtggcat ctgggagctt      120

aagaaggacg tgtatgtagt ggagttagac tggtatccag atgcccccgg agagatggtg      180

gtcttaacat gtgacactcc agaggaggac gggattacct ggacacttga ccagtcaagc      240

gaggtattgg gttctggaaa gacgcttact attcaagtca aagaatttgg ggatgccggg      300

cagtatacat gtcacaaggg cggcgaagtt ctgtcgcact ccttactttt gttacacaaa      360

aaagaagacg gcatttggtc cacagacatc cttaaggacc aaaaggagcc gaagaataag      420

acgtttctgc gctgtgaagc gaagaactat agtggtcgct ttacttgctg gtggttgacg      480

accatttcca ctgatttaac cttttcggta aagagttctc gcgggagttc cgacccacag      540

ggcgtgactt gtggcgcagc cacactttcg gcggaacgcg ttcgtgggga caataaggaa      600

tacgaatatt cggtcgagtg tcaggaagat tcagcttgcc ctgccgctga ggagtcactt      660

ccgattgaag tgatggttga cgccgtgcac aaattaaagt atgaaaatta cacgtcatct      720

ttctttatcc gtgacattat taagcccgac ccgccaaaga atctgcagct taaacccctg      780

aagaacagcc gccaggtgga agtaagctgg gaatatcctg acacctggtc cactccgcat      840

tcgtatttct cgttgacgtt ttgtgttcag gtgcagggaa agagcaagcg cgaaaagaag      900

gatcgcgtct ttacagacaa aacgtccgcg acggttattt gtcgtaagaa tgctagtatc      960

tctgttcgcg ctcaggaccg ttattactca tctagttggt cggagtgggc ctcggttccc     1020

tgctctgggg gtggaggatc gggtggaggt ggctcgggag gtggcggctc ccgtaattta     1080

ccggtggcta ctcctgaccc agggatgttc ccgtgcttgc accatagcca aaacttactt     1140

cgcgctgtca gcaacatgct tcagaaagca cgtcaaacgc ttgagtttta cccgtgtact     1200

agcgaagaga tcgatcacga ggacattacc aaagacaaaa cctccaccgt cgaggcctgc     1260

cttccacttg aactgacgaa aaatgagtca tgcttaaatt ctcgtgaaac ctccttcatt     1320

actaacggat cgtgcctggc ctcgcgcaag acttcgttca tgatggcatt atgcttgtcg     1380

tctatttatg aagaccttaa aatgtatcaa gtggagttca agacgatgaa tgcaaaactt     1440

cttatggacc cgaagcgtca aatcttctta gaccaaaaca tgttggccgt gatcgatgaa     1500

ctgatgcaag ccttgaattt taattcggaa actgtaccgc aaaaatcttc tcttgaagaa     1560

ccggatttct ataagaccaa aattaaactt tgtattttac ttcacgcttt ccgcatccgt     1620

gcagtaacta tcgaccgcgt aatgagttac cttaacgcct cgggtggcga gctcggtggc     1680

agtggtaagc ctatccctaa ccctctcctc ggcctcgatt ctacgggatc cggtcatcac     1740

caccatcacc atcaccat                                                   1758


<210> 1157
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1157
atggggtaca aaatgaacat tagctcgctt cgcaaagcat tcatttttat gggggctgtt       60

gcagctttaa gccttgtcaa tgcccagtca gcgcttgcc                              99


<210> 1158
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1158
atgaaaaaga tttggctggc tcttgccggt ttagtcctgg cattcagcgc aagcgcg          57


<210> 1159
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1159
atgaaacaga gcacaatcgc tttagccttg ctgcctcttc ttttcacgcc tgtcacgaag       60

gca                                                                     63


<210> 1160
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1160
atgaagcagg ctctgcgcgt ggcatttggg ttcctgatct tatgggcgtc cgtcttacac       60

gca                                                                     63


<210> 1161
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1161
atgaaaatca agacgggggc acgcattctt gccttgagcg ccttgacaac gatgatgttc       60

agtgcaagtg cattagcg                                                     78


<210> 1162
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1162
atgaataaga aagtcttgac attgtcggcg gtcatggcct cgatgttgtt cggggcagca       60

gcccacgca                                                               69


<210> 1163
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1163
atgatgaagc gtaacatctt agccgttatt gtccccgcat tgcttgtggc cgggacggct       60

aacgca                                                                  66


<210> 1164
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1164
atgaagaaga ctgccatcgc tattgccgtc gcccttgcgg gtttcgcaac cgtggcgcaa       60

gca                                                                     63


<210> 1165
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1165
atgcgcgtgt tattgttctt gctgctgagc ttgtttatgt taccagcttt cagt             54


<210> 1166
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1166
atgatgatta ccttacgcaa gttgcccctt gcggtagccg ttgctgctgg tgtgatgtcc       60

gcgcaagcaa tggct                                                        75


<210> 1167
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1167
atgaaatatc ttcttccaac ggctgctgct ggtttattgc ttcttgccgc ccagcctgcg       60

atggct                                                                  66


<210> 1168
<211> 1554
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1168
atctgggagc ttaagaagga cgtgtatgta gtggagttag actggtatcc agatgccccc       60

ggagagatgg tggtcttaac atgtgacact ccagaggagg acgggattac ctggacactt      120

gaccagtcaa gcgaggtatt gggttctgga aagacgctta ctattcaagt caaagaattt      180

ggggatgccg ggcagtatac atgtcacaag ggcggcgaag ttctgtcgca ctccttactt      240

ttgttacaca aaaaagaaga cggcatttgg tccacagaca tccttaagga ccaaaaggag      300

ccgaagaata agacgtttct gcgctgtgaa gcgaagaact atagtggtcg ctttacttgc      360

tggtggttga cgaccatttc cactgattta accttttcgg taaagagttc tcgcgggagt      420

tccgacccac agggcgtgac ttgtggcgca gccacacttt cggcggaacg cgttcgtggg      480

gacaataagg aatacgaata ttcggtcgag tgtcaggaag attcagcttg ccctgccgct      540

gaggagtcac ttccgattga agtgatggtt gacgccgtgc acaaattaaa gtatgaaaat      600

tacacgtcat ctttctttat ccgtgacatt attaagcccg acccgccaaa gaatctgcag      660

cttaaacccc tgaagaacag ccgccaggtg gaagtaagct gggaatatcc tgacacctgg      720

tccactccgc attcgtattt ctcgttgacg ttttgtgttc aggtgcaggg aaagagcaag      780

cgcgaaaaga aggatcgcgt ctttacagac aaaacgtccg cgacggttat ttgtcgtaag      840

aatgctagta tctctgttcg cgctcaggac cgttattact catctagttg gtcggagtgg      900

gcctcggttc cctgctctgg gggtggagga tcgggtggag gtggctcggg aggtggcggc      960

tcccgtaatt taccggtggc tactcctgac ccagggatgt tcccgtgctt gcaccatagc     1020

caaaacttac ttcgcgctgt cagcaacatg cttcagaaag cacgtcaaac gcttgagttt     1080

tacccgtgta ctagcgaaga gatcgatcac gaggacatta ccaaagacaa aacctccacc     1140

gtcgaggcct gccttccact tgaactgacg aaaaatgagt catgcttaaa ttctcgtgaa     1200

acctccttca ttactaacgg atcgtgcctg gcctcgcgca agacttcgtt catgatggca     1260

ttatgcttgt cgtctattta tgaagacctt aaaatgtatc aagtggagtt caagacgatg     1320

aatgcaaaac ttcttatgga cccgaagcgt caaatcttct tagaccaaaa catgttggcc     1380

gtgatcgatg aactgatgca agccttgaat tttaattcgg aaactgtacc gcaaaaatct     1440

tctcttgaag aaccggattt ctataagacc aaaattaaac tttgtatttt acttcacgct     1500

ttccgcatcc gtgcagtaac tatcgaccgc gtaatgagtt accttaacgc ctcg           1554


<210> 1169
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1169
Met Gly Tyr Lys Met Asn Ile Ser Ser Leu Arg Lys Ala Phe Ile Phe 
1               5                   10                  15      


Met Gly Ala Val Ala Ala Leu Ser Leu Val Asn Ala Gln Ser Ala Leu 
            20                  25                  30          


Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu Gly Gly Gly Ile 
        35                  40                  45              


Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro 
    50                  55                  60                  


Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu 
65                  70                  75                  80  


Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser 
                85                  90                  95      


Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln 
            100                 105                 110         


Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu 
        115                 120                 125             


Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp 
    130                 135                 140                 


Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn 
145                 150                 155                 160 


Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp 
                165                 170                 175     


Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly 
            180                 185                 190         


Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp 
        195                 200                 205             


Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys 
    210                 215                 220                 


Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala Val 
225                 230                 235                 240 


His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp 
                245                 250                 255     


Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys 
            260                 265                 270         


Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser 
        275                 280                 285             


Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly 
    290                 295                 300                 


Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser 
305                 310                 315                 320 


Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln 
                325                 330                 335     


Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        355                 360                 365             


Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
    370                 375                 380                 


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
385                 390                 395                 400 


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
                405                 410                 415     


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
            420                 425                 430         


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
        435                 440                 445             


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
    450                 455                 460                 


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
465                 470                 475                 480 


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
                485                 490                 495     


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
            500                 505                 510         


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
        515                 520                 525             


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
    530                 535                 540                 


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
545                 550                 555                 560 


Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser Gly Lys Pro Ile 
                565                 570                 575     


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser Gly His His His 
            580                 585                 590         


His His His His His 
        595         


<210> 1170
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1170
Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu Gly Gly 
            20                  25                  30          


Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
        35                  40                  45              


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
    50                  55                  60                  


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
65                  70                  75                  80  


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
                85                  90                  95      


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
            100                 105                 110         


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
        115                 120                 125             


Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 
    130                 135                 140                 


Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 
145                 150                 155                 160 


Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro 
                165                 170                 175     


Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg 
            180                 185                 190         


Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 
        195                 200                 205             


Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp 
    210                 215                 220                 


Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
225                 230                 235                 240 


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
                245                 250                 255     


Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
            260                 265                 270         


Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val 
        275                 280                 285             


Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys 
    290                 295                 300                 


Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg 
305                 310                 315                 320 


Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 
                325                 330                 335     


Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
        355                 360                 365             


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
    370                 375                 380                 


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
385                 390                 395                 400 


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
                405                 410                 415     


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
            420                 425                 430         


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
        435                 440                 445             


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
    450                 455                 460                 


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
465                 470                 475                 480 


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
                485                 490                 495     


Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys 
            500                 505                 510         


Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
        515                 520                 525             


Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val 
    530                 535                 540                 


Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser Gly Lys 
545                 550                 555                 560 


Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser Gly His 
                565                 570                 575     


His His His His His His His 
            580             


<210> 1171
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1171
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu 
            20                  25                  30          


Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu 
        35                  40                  45              


Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp 
    50                  55                  60                  


Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu 
65                  70                  75                  80  


Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly 
                85                  90                  95      


Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His 
            100                 105                 110         


Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp 
        115                 120                 125             


Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys 
    130                 135                 140                 


Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr 
145                 150                 155                 160 


Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser 
                165                 170                 175     


Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg 
            180                 185                 190         


Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu 
        195                 200                 205             


Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met 
    210                 215                 220                 


Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe 
225                 230                 235                 240 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu 
                245                 250                 255     


Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro 
            260                 265                 270         


Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val 
        275                 280                 285             


Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr 
    290                 295                 300                 


Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser 
305                 310                 315                 320 


Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala 
                325                 330                 335     


Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
        355                 360                 365             


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
    370                 375                 380                 


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
385                 390                 395                 400 


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
                405                 410                 415     


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
            420                 425                 430         


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
        435                 440                 445             


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
    450                 455                 460                 


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
465                 470                 475                 480 


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
                485                 490                 495     


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
            500                 505                 510         


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
        515                 520                 525             


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
    530                 535                 540                 


Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser 
545                 550                 555                 560 


Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser 
                565                 570                 575     


Gly His His His His His His His His 
            580                 585 


<210> 1172
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1172
Met Lys Gln Ala Leu Arg Val Ala Phe Gly Phe Leu Ile Leu Trp Ala 
1               5                   10                  15      


Ser Val Leu His Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu 
            20                  25                  30          


Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu 
        35                  40                  45              


Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp 
    50                  55                  60                  


Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu 
65                  70                  75                  80  


Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly 
                85                  90                  95      


Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His 
            100                 105                 110         


Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp 
        115                 120                 125             


Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys 
    130                 135                 140                 


Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr 
145                 150                 155                 160 


Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser 
                165                 170                 175     


Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg 
            180                 185                 190         


Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu 
        195                 200                 205             


Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met 
    210                 215                 220                 


Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe 
225                 230                 235                 240 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu 
                245                 250                 255     


Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro 
            260                 265                 270         


Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val 
        275                 280                 285             


Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr 
    290                 295                 300                 


Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser 
305                 310                 315                 320 


Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala 
                325                 330                 335     


Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
        355                 360                 365             


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
    370                 375                 380                 


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
385                 390                 395                 400 


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
                405                 410                 415     


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
            420                 425                 430         


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
        435                 440                 445             


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
    450                 455                 460                 


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
465                 470                 475                 480 


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
                485                 490                 495     


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
            500                 505                 510         


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
        515                 520                 525             


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
    530                 535                 540                 


Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser 
545                 550                 555                 560 


Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser 
                565                 570                 575     


Gly His His His His His His His His 
            580                 585 


<210> 1173
<211> 590
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1173
Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      


Thr Met Met Phe Ser Ala Ser Ala Leu Ala Val Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Gln Leu Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val 
        35                  40                  45              


Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val 
    50                  55                  60                  


Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu 
65                  70                  75                  80  


Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln 
                85                  90                  95      


Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly 
            100                 105                 110         


Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly 
        115                 120                 125             


Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys 
    130                 135                 140                 


Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys 
145                 150                 155                 160 


Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser 
                165                 170                 175     


Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr 
            180                 185                 190         


Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser 
        195                 200                 205             


Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu 
    210                 215                 220                 


Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn 
225                 230                 235                 240 


Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro 
                245                 250                 255     


Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val 
            260                 265                 270         


Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser 
        275                 280                 285             


Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys 
    290                 295                 300                 


Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys 
305                 310                 315                 320 


Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser 
                325                 330                 335     


Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr 
        355                 360                 365             


Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu 
    370                 375                 380                 


Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe 
385                 390                 395                 400 


Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp 
                405                 410                 415     


Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn 
            420                 425                 430         


Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser 
        435                 440                 445             


Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser 
    450                 455                 460                 


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met 
465                 470                 475                 480 


Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln 
                485                 490                 495     


Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn 
            500                 505                 510         


Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr 
        515                 520                 525             


Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg 
    530                 535                 540                 


Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly 
545                 550                 555                 560 


Glu Leu Gly Gly Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
                565                 570                 575     


Asp Ser Thr Gly Ser Gly His His His His His His His His 
            580                 585                 590 


<210> 1174
<211> 587
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1174
Met Asn Lys Lys Val Leu Thr Leu Ser Ala Val Met Ala Ser Met Leu 
1               5                   10                  15      


Phe Gly Ala Ala Ala His Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
        35                  40                  45              


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
    50                  55                  60                  


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
65                  70                  75                  80  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
                85                  90                  95      


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
            100                 105                 110         


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
        115                 120                 125             


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
    130                 135                 140                 


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
145                 150                 155                 160 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
                165                 170                 175     


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
            180                 185                 190         


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
        195                 200                 205             


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
    210                 215                 220                 


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
225                 230                 235                 240 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
                245                 250                 255     


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
            260                 265                 270         


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
        275                 280                 285             


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
    290                 295                 300                 


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
305                 310                 315                 320 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
                325                 330                 335     


Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
        355                 360                 365             


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
    370                 375                 380                 


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
385                 390                 395                 400 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
                405                 410                 415     


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
            420                 425                 430         


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
        435                 440                 445             


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
    450                 455                 460                 


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
465                 470                 475                 480 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
                485                 490                 495     


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
            500                 505                 510         


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
        515                 520                 525             


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
    530                 535                 540                 


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly 
545                 550                 555                 560 


Gly Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
                565                 570                 575     


Gly Ser Gly His His His His His His His His 
            580                 585         


<210> 1175
<211> 586
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1175
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln 
            20                  25                  30          


Leu Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu 
        35                  40                  45              


Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys 
    50                  55                  60                  


Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser 
65                  70                  75                  80  


Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe 
                85                  90                  95      


Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser 
            100                 105                 110         


His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr 
        115                 120                 125             


Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg 
    130                 135                 140                 


Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr 
145                 150                 155                 160 


Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser 
                165                 170                 175     


Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu 
            180                 185                 190         


Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln 
        195                 200                 205             


Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val 
    210                 215                 220                 


Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser 
225                 230                 235                 240 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
                245                 250                 255     


Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr 
            260                 265                 270         


Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys 
        275                 280                 285             


Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe 
    290                 295                 300                 


Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile 
305                 310                 315                 320 


Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp 
                325                 330                 335     


Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
        355                 360                 365             


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
    370                 375                 380                 


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
385                 390                 395                 400 


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
                405                 410                 415     


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
            420                 425                 430         


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
        435                 440                 445             


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
    450                 455                 460                 


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
465                 470                 475                 480 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
                485                 490                 495     


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
            500                 505                 510         


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
        515                 520                 525             


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
    530                 535                 540                 


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly 
545                 550                 555                 560 


Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly 
                565                 570                 575     


Ser Gly His His His His His His His His 
            580                 585     


<210> 1176
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1176
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu 
            20                  25                  30          


Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu 
        35                  40                  45              


Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp 
    50                  55                  60                  


Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu 
65                  70                  75                  80  


Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly 
                85                  90                  95      


Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His 
            100                 105                 110         


Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp 
        115                 120                 125             


Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys 
    130                 135                 140                 


Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr 
145                 150                 155                 160 


Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser 
                165                 170                 175     


Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg 
            180                 185                 190         


Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu 
        195                 200                 205             


Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met 
    210                 215                 220                 


Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe 
225                 230                 235                 240 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu 
                245                 250                 255     


Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro 
            260                 265                 270         


Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val 
        275                 280                 285             


Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr 
    290                 295                 300                 


Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser 
305                 310                 315                 320 


Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala 
                325                 330                 335     


Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
        355                 360                 365             


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
    370                 375                 380                 


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
385                 390                 395                 400 


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
                405                 410                 415     


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
            420                 425                 430         


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
        435                 440                 445             


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
    450                 455                 460                 


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
465                 470                 475                 480 


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
                485                 490                 495     


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
            500                 505                 510         


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
        515                 520                 525             


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
    530                 535                 540                 


Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser 
545                 550                 555                 560 


Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser 
                565                 570                 575     


Gly His His His His His His His His 
            580                 585 


<210> 1177
<211> 582
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1177
Met Arg Val Leu Leu Phe Leu Leu Leu Ser Leu Phe Met Leu Pro Ala 
1               5                   10                  15      


Phe Ser Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu Gly Gly Gly 
            20                  25                  30          


Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
        35                  40                  45              


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
    50                  55                  60                  


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
65                  70                  75                  80  


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
                85                  90                  95      


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
            100                 105                 110         


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
        115                 120                 125             


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
    130                 135                 140                 


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
145                 150                 155                 160 


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
                165                 170                 175     


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
            180                 185                 190         


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
        195                 200                 205             


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
    210                 215                 220                 


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
225                 230                 235                 240 


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
                245                 250                 255     


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
            260                 265                 270         


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
        275                 280                 285             


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
    290                 295                 300                 


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
305                 310                 315                 320 


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
                325                 330                 335     


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
        355                 360                 365             


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
    370                 375                 380                 


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
385                 390                 395                 400 


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
                405                 410                 415     


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
            420                 425                 430         


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
        435                 440                 445             


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
    450                 455                 460                 


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
465                 470                 475                 480 


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
                485                 490                 495     


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
            500                 505                 510         


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
        515                 520                 525             


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
    530                 535                 540                 


Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser Gly Lys Pro 
545                 550                 555                 560 


Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser Gly His His 
                565                 570                 575     


His His His His His His 
            580         


<210> 1178
<211> 589
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1178
Met Met Ile Thr Leu Arg Lys Leu Pro Leu Ala Val Ala Val Ala Ala 
1               5                   10                  15      


Gly Val Met Ser Ala Gln Ala Met Ala Val Asp Tyr Lys Asp Asp Asp 
            20                  25                  30          


Asp Lys Gln Leu Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr 
        35                  40                  45              


Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val 
    50                  55                  60                  


Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp 
65                  70                  75                  80  


Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val 
                85                  90                  95      


Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu 
            100                 105                 110         


Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile 
        115                 120                 125             


Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr 
    130                 135                 140                 


Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp 
145                 150                 155                 160 


Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser 
                165                 170                 175     


Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu 
            180                 185                 190         


Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val 
        195                 200                 205             


Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro 
    210                 215                 220                 


Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr 
225                 230                 235                 240 


Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys 
                245                 250                 255     


Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser 
            260                 265                 270         


Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 
        275                 280                 285             


Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp 
    290                 295                 300                 


Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn 
305                 310                 315                 320 


Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp 
                325                 330                 335     


Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro 
        355                 360                 365             


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
    370                 375                 380                 


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
385                 390                 395                 400 


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
                405                 410                 415     


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
            420                 425                 430         


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
        435                 440                 445             


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
    450                 455                 460                 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
465                 470                 475                 480 


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
                485                 490                 495     


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
            500                 505                 510         


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
        515                 520                 525             


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
    530                 535                 540                 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu 
545                 550                 555                 560 


Leu Gly Gly Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
                565                 570                 575     


Ser Thr Gly Ser Gly His His His His His His His His 
            580                 585                 


<210> 1179
<211> 586
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1179
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln 
            20                  25                  30          


Leu Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu 
        35                  40                  45              


Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys 
    50                  55                  60                  


Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser 
65                  70                  75                  80  


Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe 
                85                  90                  95      


Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser 
            100                 105                 110         


His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr 
        115                 120                 125             


Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg 
    130                 135                 140                 


Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr 
145                 150                 155                 160 


Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser 
                165                 170                 175     


Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu 
            180                 185                 190         


Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln 
        195                 200                 205             


Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val 
    210                 215                 220                 


Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser 
225                 230                 235                 240 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
                245                 250                 255     


Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr 
            260                 265                 270         


Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys 
        275                 280                 285             


Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe 
    290                 295                 300                 


Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile 
305                 310                 315                 320 


Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp 
                325                 330                 335     


Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
        355                 360                 365             


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
    370                 375                 380                 


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
385                 390                 395                 400 


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
                405                 410                 415     


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
            420                 425                 430         


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
        435                 440                 445             


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
    450                 455                 460                 


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
465                 470                 475                 480 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
                485                 490                 495     


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
            500                 505                 510         


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
        515                 520                 525             


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
    530                 535                 540                 


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly 
545                 550                 555                 560 


Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly 
                565                 570                 575     


Ser Gly His His His His His His His His 
            580                 585     


<210> 1180
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1180
Met Gly Tyr Lys Met Asn Ile Ser Ser Leu Arg Lys Ala Phe Ile Phe 
1               5                   10                  15      


Met Gly Ala Val Ala Ala Leu Ser Leu Val Asn Ala Gln Ser Ala Leu 
            20                  25                  30          


Ala 
    


<210> 1181
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1181
Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala 
            


<210> 1182
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1182
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala 
            20      


<210> 1183
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1183
Met Lys Gln Ala Leu Arg Val Ala Phe Gly Phe Leu Ile Leu Trp Ala 
1               5                   10                  15      


Ser Val Leu His Ala 
            20      


<210> 1184
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1184
Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      


Thr Met Met Phe Ser Ala Ser Ala Leu Ala 
            20                  25      


<210> 1185
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1185
Met Asn Lys Lys Val Leu Thr Leu Ser Ala Val Met Ala Ser Met Leu 
1               5                   10                  15      


Phe Gly Ala Ala Ala His Ala 
            20              


<210> 1186
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1186
Met Thr Asn Ile Thr Lys Arg Ser Leu Val Ala Ala Gly Val Leu Ala 
1               5                   10                  15      


Ala Leu Met Ala Gly Asn Val Ala Leu Ala 
            20                  25      


<210> 1187
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1187
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala 
            20      


<210> 1188
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1188
Met Arg Val Leu Leu Phe Leu Leu Leu Ser Leu Phe Met Leu Pro Ala 
1               5                   10                  15      


Phe Ser 
        


<210> 1189
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1189
Met Met Ile Thr Leu Arg Lys Leu Pro Leu Ala Val Ala Val Ala Ala 
1               5                   10                  15      


Gly Val Met Ser Ala Gln Ala Met Ala 
            20                  25  


<210> 1190
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1190
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210> 1191
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1191
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser 
        515             


<210> 1192
<211> 305
<212> PRT
<213> Homo sapiens

<400> 1192
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys 
305 


<210> 1193
<211> 197
<212> PRT
<213> Homo sapiens

<400> 1193
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 1194
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1194
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 1195
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1195
atggggtaca aaatgaacat tagctcgctt cgcaaagcat tcatttttat gggggctgtt       60

gcagctttaa gccttgtcaa tgcccagtca gcgcttgcca tgatcacttg tccgcccccc      120

atgtctgtgg aacacgcgga tatttgggta aagagctact cactgtacag ccgtgaacgt      180

tatatttgta actccggctt caaacgcaaa gcaggaactt catcactgac ggagtgtgtt      240

ttaaataaag ctactaacgt cgcgcactgg actactccct cattgaagtg catccgtgat      300

cctgctctgg gtggcggggg tagcggcggg ggtggaagcg ggggtggagg gtctggagga      360

ggtgggtcta actgggtgaa tgttatctca gatttaaaga aaattgaaga cctgatccaa      420

tctatgcaca tcgacgctac tctgtataca gaatcagatg tacatccttc gtgtaaagtg      480

accgcgatga agtgtttttt gcttgagctg caagtaattt cccttgagtc cggggacgct      540

tcaatccatg acacggtcga gaacctgatc attctggcaa acaatagttt atcatcgaac      600

ggtaatgtta ccgaatcggg ttgcaaagaa tgcgaagagt tagaggaaaa gaacattaaa      660

gaatttttgc aatccttcgt tcacattgtg cagatgttca ttaatacatc g               711


<210> 1196
<211> 666
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1196
atgcgcgtgt tattgttctt gctgctgagc ttgtttatgt taccagcttt cagtatgatc       60

acttgtccgc cccccatgtc tgtggaacac gcggatattt gggtaaagag ctactcactg      120

tacagccgtg aacgttatat ttgtaactcc ggcttcaaac gcaaagcagg aacttcatca      180

ctgacggagt gtgttttaaa taaagctact aacgtcgcgc actggactac tccctcattg      240

aagtgcatcc gtgatcctgc tctgggtggc gggggtagcg gcgggggtgg aagcgggggt      300

ggagggtctg gaggaggtgg gtctaactgg gtgaatgtta tctcagattt aaagaaaatt      360

gaagacctga tccaatctat gcacatcgac gctactctgt atacagaatc agatgtacat      420

ccttcgtgta aagtgaccgc gatgaagtgt tttttgcttg agctgcaagt aatttccctt      480

gagtccgggg acgcttcaat ccatgacacg gtcgagaacc tgatcattct ggcaaacaat      540

agtttatcat cgaacggtaa tgttaccgaa tcgggttgca aagaatgcga agagttagag      600

gaaaagaaca ttaaagaatt tttgcaatcc ttcgttcaca ttgtgcagat gttcattaat      660

acatcg                                                                 666


<210> 1197
<211> 678
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1197
atgaaatatc ttcttccaac ggctgctgct ggtttattgc ttcttgccgc ccagcctgcg       60

atggctatga tcacttgtcc gccccccatg tctgtggaac acgcggatat ttgggtaaag      120

agctactcac tgtacagccg tgaacgttat atttgtaact ccggcttcaa acgcaaagca      180

ggaacttcat cactgacgga gtgtgtttta aataaagcta ctaacgtcgc gcactggact      240

actccctcat tgaagtgcat ccgtgatcct gctctgggtg gcgggggtag cggcgggggt      300

ggaagcgggg gtggagggtc tggaggaggt gggtctaact gggtgaatgt tatctcagat      360

ttaaagaaaa ttgaagacct gatccaatct atgcacatcg acgctactct gtatacagaa      420

tcagatgtac atccttcgtg taaagtgacc gcgatgaagt gttttttgct tgagctgcaa      480

gtaatttccc ttgagtccgg ggacgcttca atccatgaca cggtcgagaa cctgatcatt      540

ctggcaaaca atagtttatc atcgaacggt aatgttaccg aatcgggttg caaagaatgc      600

gaagagttag aggaaaagaa cattaaagaa tttttgcaat ccttcgttca cattgtgcag      660

atgttcatta atacatcg                                                    678


<210> 1198
<211> 612
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1198
atgatcactt gtccgccccc catgtctgtg gaacacgcgg atatttgggt aaagagctac       60

tcactgtaca gccgtgaacg ttatatttgt aactccggct tcaaacgcaa agcaggaact      120

tcatcactga cggagtgtgt tttaaataaa gctactaacg tcgcgcactg gactactccc      180

tcattgaagt gcatccgtga tcctgctctg ggtggcgggg gtagcggcgg gggtggaagc      240

gggggtggag ggtctggagg aggtgggtct aactgggtga atgttatctc agatttaaag      300

aaaattgaag acctgatcca atctatgcac atcgacgcta ctctgtatac agaatcagat      360

gtacatcctt cgtgtaaagt gaccgcgatg aagtgttttt tgcttgagct gcaagtaatt      420

tcccttgagt ccggggacgc ttcaatccat gacacggtcg agaacctgat cattctggca      480

aacaatagtt tatcatcgaa cggtaatgtt accgaatcgg gttgcaaaga atgcgaagag      540

ttagaggaaa agaacattaa agaatttttg caatccttcg ttcacattgt gcagatgttc      600

attaatacat cg                                                          612


<210> 1199
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1199
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 1200
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1200
Met Gly Tyr Lys Met Asn Ile Ser Ser Leu Arg Lys Ala Phe Ile Phe 
1               5                   10                  15      


Met Gly Ala Val Ala Ala Leu Ser Leu Val Asn Ala Gln Ser Ala Leu 
            20                  25                  30          


Ala Met Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
        35                  40                  45              


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
    50                  55                  60                  


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
65                  70                  75                  80  


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
                85                  90                  95      


Cys Ile Arg Asp Pro Ala Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Val Asn Val 
        115                 120                 125             


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
    130                 135                 140                 


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
145                 150                 155                 160 


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
                165                 170                 175     


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
            180                 185                 190         


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
        195                 200                 205             


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
    210                 215                 220                 


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
225                 230                 235         


<210> 1201
<211> 222
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1201
Met Arg Val Leu Leu Phe Leu Leu Leu Ser Leu Phe Met Leu Pro Ala 
1               5                   10                  15      


Phe Ser Met Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp 
            20                  25                  30          


Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys 
        35                  40                  45              


Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys 
    50                  55                  60                  


Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu 
65                  70                  75                  80  


Lys Cys Ile Arg Asp Pro Ala Leu Gly Gly Gly Gly Ser Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Val Asn 
            100                 105                 110         


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
        115                 120                 125             


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
    130                 135                 140                 


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
145                 150                 155                 160 


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
                165                 170                 175     


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
            180                 185                 190         


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
        195                 200                 205             


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    210                 215                 220         


<210> 1202
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1202
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Met Ile Thr Cys Pro Pro Pro Met Ser Val 
            20                  25                  30          


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
        35                  40                  45              


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
    50                  55                  60                  


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
65                  70                  75                  80  


Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Gly Gly Gly Gly 
                85                  90                  95      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
        115                 120                 125             


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
    130                 135                 140                 


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
145                 150                 155                 160 


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
                165                 170                 175     


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
            180                 185                 190         


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
        195                 200                 205             


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
    210                 215                 220                 


Thr Ser 
225     


<210> 1203
<211> 204
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1203
Met Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
1               5                   10                  15      


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
            20                  25                  30          


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
        35                  40                  45              


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    50                  55                  60                  


Ile Arg Asp Pro Ala Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Val Asn Val Ile 
                85                  90                  95      


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
            100                 105                 110         


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
        115                 120                 125             


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
    130                 135                 140                 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
145                 150                 155                 160 


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
                165                 170                 175     


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
            180                 185                 190         


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
        195                 200                 


<210> 1204
<211> 114
<212> PRT
<213> Homo sapiens

<400> 1204
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 1205
<211> 73
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1205
Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys Ile Ser Ile Ser Asn 
1               5                   10                  15      


Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu Glu Ile Ile Pro Ala 
            20                  25                  30          


Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala Thr Met Lys Lys Lys 
        35                  40                  45              


Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys Ala Ile Lys Asn Leu 
    50                  55                  60                  


Leu Lys Ala Val Ser Lys Glu Arg Ser 
65                  70              


<210> 1206
<211> 94
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1206
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser 
                85                  90                  


<210> 1207
<211> 222
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1207
gtgcccctga gccgcaccgt gcgttgtacg tgtatctcca tctcaaacca gccggtaaac       60

ccgcgtagtt tagaaaaact ggagattatc ccagccagcc agttttgccc gcgcgttgag      120

attattgcga ccatgaagaa aaaaggggaa aaacgttgcc ttaatccaga aagtaaggct      180

atcaaaaacc tgttgaaagc tgtctcgaaa gagcgttcct aa                         222


<210> 1208
<211> 285
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1208
atgaagcaaa gtacgatcgc ccttgcgctg ttgccccttc ttttcacgcc cgtcaccaag       60

gcagtgcccc tgagccgcac cgtgcgttgt acgtgtatct ccatctcaaa ccagccggta      120

aacccgcgta gtttagaaaa actggagatt atcccagcca gccagttttg cccgcgcgtt      180

gagattattg cgaccatgaa gaaaaaaggg gaaaaacgtt gccttaatcc agaaagtaag      240

gctatcaaaa acctgttgaa agctgtctcg aaagagcgtt cctaa                      285


<210> 1209
<211> 273
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1209
Met Asp Phe Ser Asn Met Ser Ile Leu His Tyr Leu Ala Asn Ile Val 
1               5                   10                  15      


Asp Ile Leu Val Val Trp Phe Val Ile Tyr Lys Val Ile Met Leu Ile 
            20                  25                  30          


Arg Gly Thr Lys Ala Val Gln Leu Leu Lys Gly Ile Phe Ile Ile Ile 
        35                  40                  45              


Ala Val Lys Leu Leu Ser Gly Phe Phe Gly Leu Gln Thr Val Glu Trp 
    50                  55                  60                  


Ile Thr Asp Gln Met Leu Thr Trp Gly Phe Leu Ala Ile Ile Ile Ile 
65                  70                  75                  80  


Phe Gln Pro Glu Leu Arg Arg Ala Leu Glu Thr Leu Gly Arg Gly Asn 
                85                  90                  95      


Ile Phe Thr Arg Tyr Gly Ser Arg Ile Glu Arg Glu Gln His His Leu 
            100                 105                 110         


Ile Glu Ser Ile Glu Lys Ser Thr Gln Tyr Met Ala Lys Arg Arg Ile 
        115                 120                 125             


Gly Ala Leu Ile Ser Val Ala Arg Asp Thr Gly Met Asp Asp Tyr Ile 
    130                 135                 140                 


Glu Thr Gly Ile Pro Leu Asn Ala Lys Ile Ser Ser Gln Leu Leu Ile 
145                 150                 155                 160 


Asn Ile Phe Ile Pro Asn Thr Pro Leu His Asp Gly Ala Val Ile Ile 
                165                 170                 175     


Lys Gly Asn Glu Ile Ala Ser Ala Ala Ser Tyr Leu Pro Leu Ser Asp 
            180                 185                 190         


Ser Pro Phe Leu Ser Lys Glu Leu Gly Thr Arg His Arg Ala Ala Leu 
        195                 200                 205             


Gly Ile Ser Glu Val Thr Asp Ser Ile Thr Ile Val Val Ser Glu Glu 
    210                 215                 220                 


Thr Gly Gly Ile Ser Leu Thr Lys Gly Gly Glu Leu Phe Arg Asp Val 
225                 230                 235                 240 


Ser Glu Glu Glu Leu His Lys Ile Leu Leu Lys Glu Leu Val Thr Val 
                245                 250                 255     


Thr Ala Lys Lys Pro Ser Ile Phe Ser Lys Trp Lys Gly Gly Lys Ser 
            260                 265                 270         


Glu 
    


<210> 1210
<211> 822
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1210
atggactttt ccaacatgag tatccttcac tatttagcga atattgtaga cattttggtg       60

gtttggttcg taatttacaa ggttatcatg cttatccgcg gcacgaaagc cgtccagctg      120

ttgaagggga ttttcattat tattgccgtc aagttactta gcggcttctt cggattgcag      180

acagtggaat ggattactga tcaaatgctg acttggggtt tcttagccat tatcattatc      240

tttcaaccgg aattgcgtcg tgccctggag actttggggc gtggcaatat ctttacccgc      300

tatggatcac gcattgagcg tgaacaacac caccttattg agtctattga aaagtccacg      360

caatacatgg cgaagcgtcg cattggagct ttgatctctg tggctcgtga tacaggcatg      420

gacgactaca tcgagactgg cattccgctt aatgcgaaaa tctcatcgca attattgatt      480

aatatcttca tccccaatac ccctcttcac gatggcgcag tgatcattaa aggtaacgag      540

atcgcgagcg ctgccagtta tctgccattg tccgactcgc cgtttctttc taaggagctg      600

ggaactcgcc atcgtgccgc attagggatt tccgaggtga cagattcaat cacaatcgtt      660

gtcagcgagg aaacaggtgg gatttccctt acgaagggag gcgaactgtt ccgtgatgta      720

tccgaagaag aattgcataa gattttgctt aaagagctgg tgactgtcac agctaaaaaa      780

ccaagcattt tctccaaatg gaaaggaggt aagtccgagt ga                         822


<210> 1211
<211> 3787
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1211
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttt      900

aagacccact ttcacattta agttgttttt ctaatccgca tatgatcaat tcaaggccga      960

ataagaaggc tggctctgca ccttggtgat caaataattc gatagcttgt cgtaataatg     1020

gcggcatact atcagtagta ggtgtttccc tttcttcttt agcgacttga tgctcttgat     1080

cttccaatac gcaacctaaa gtaaaatgcc ccacagcgct gagtgcatat aatgcattct     1140

ctagtgaaaa accttgttgg cataaaaagg ctaattgatt ttcgagagtt tcatactgtt     1200

tttctgtagg ccgtgtacct aaatgtactt ttgctccatc gcgatgactt agtaaagcac     1260

atctaaaact tttagcgtta ttacgtaaaa aatcttgcca gctttcccct tctaaagggc     1320

aaaagtgagt atggtgccta tctaacatct caatggctaa ggcgtcgagc aaagcccgct     1380

tattttttac atgccaatac aatgtaggct gctctacacc tagcttctgg gcgagtttac     1440

gggttgttaa accttcgatt ccgacctcat taagcagctc taatgcgctg ttaatcactt     1500

tacttttatc taatctagac atcattaatt cctaattttt gttgacactc tatcattgat     1560

agagttattt taccactccc tatcagtgat agagaaaagt gaacccgcat cccacgctaa     1620

ctaatataag gggggcaaga atggactttt ccaacatgag tatccttcac tatttagcga     1680

atattgtaga cattttggtg gtttggttcg taatttacaa ggttatcatg cttatccgcg     1740

gcacgaaagc cgtccagctg ttgaagggga ttttcattat tattgccgtc aagttactta     1800

gcggcttctt cggattgcag acagtggaat ggattactga tcaaatgctg acttggggtt     1860

tcttagccat tatcattatc tttcaaccgg aattgcgtcg tgccctggag actttggggc     1920

gtggcaatat ctttacccgc tatggatcac gcattgagcg tgaacaacac caccttattg     1980

agtctattga aaagtccacg caatacatgg cgaagcgtcg cattggagct ttgatctctg     2040

tggctcgtga tacaggcatg gacgactaca tcgagactgg cattccgctt aatgcgaaaa     2100

tctcatcgca attattgatt aatatcttca tccccaatac ccctcttcac gatggcgcag     2160

tgatcattaa aggtaacgag atcgcgagcg ctgccagtta tctgccattg tccgactcgc     2220

cgtttctttc taaggagctg ggaactcgcc atcgtgccgc attagggatt tccgaggtga     2280

cagattcaat cacaatcgtt gtcagcgagg aaacaggtgg gatttccctt acgaagggag     2340

gcgaactgtt ccgtgatgta tccgaagaag aattgcataa gattttgctt aaagagctgg     2400

tgactgtcac agctaaaaaa ccaagcattt tctccaaatg gaaaggaggt aagtccgagt     2460

gaggaggaac gattggtaaa cccggtgaac gcatgagaaa gcccccggaa gatcaccttc     2520

cgggggcttt tttattgcgc ggaccaaaac gaaaaaagac gctcgaaagc gtctcttttc     2580

tggaatttgg taccgaggcg taatgctctg ccagtgttac aaccaattaa ccaattctga     2640

ttagaaaaac tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag gattatcaat     2700

accatatttt tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga ggcagttcca     2760

taggatggca agatcctggt atcggtctgc gattccgact cgtccaacat caatacaacc     2820

tattaatttc ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat gagtgacgac     2880

tgaatccggt gagaatggca aaagcttatg catttctttc cagacttgtt caacaggcca     2940

gccattacgc tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca ttcgtgattg     3000

cgcctgagcg agacgaaata cgcgatcgct gttaaaagga caattacaaa caggaatcga     3060

atgcaaccgg cgcaggaaca ctgccagcgc atcaacaata ttttcacctg aatcaggata     3120

ttcttctaat acctggaatg ctgttttccc ggggatcgca gtggtgagta accatgcatc     3180

atcaggagta cggataaaat gcttgatggt cggaagaggc ataaattccg tcagccagtt     3240

tagtctgacc atctcatctg taacatcatt ggcaacgcta cctttgccat gtttcagaaa     3300

caactctggc gcatcgggct tcccatacaa tcgatagatt gtcgcacctg attgcccgac     3360

attatcgcga gcccatttat acccatataa atcagcatcc atgttggaat ttaatcgcgg     3420

cctcgagcaa gacgtttccc gttgaatatg gctcataaca ccccttgtat tactgtttat     3480

gtaagcagac agttttattg ttcatgatga tatattttta tcttgtgcaa tgtaacatca     3540

gagattttga gacacaacgt ggctttgttg aataaatcga acttttgctg agttgaagga     3600

tcagatcacg catcttcccg acaacgcaga ccgttccgtg gcaaagcaaa agttcaaaat     3660

caccaactgg tccacctaca acaaagctct catcaaccgt ggctccctca ctttctggct     3720

ggatgatggg gcgattcagg cctggtatga gtcagcaaca ccttcttcac gaggcagacc     3780

tcagcgc                                                               3787


<210> 1212
<211> 5519
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1212
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagctat      240

ttaggtgaca ctatagaata ctcaagctat gcatcaagct tggtaccgag ctcggatcca      300

ctagtaacgg ccgccagtgt gctggaattc gcccttttaa gacccacttt cacatttaag      360

ttgtttttct aatccgcaga tgatcaattc aaggccgaat aagaaggctg gctctgcacc      420

ttggtgatca aataattcga tagcttgtcg taataatggc ggcatactat cagtagtagg      480

tgtttccctt tcttctttag cgacttgatg ctcttgatct tccaatacgc aacctaaagt      540

aaaatgcccc acagcgctga gtgcatataa tgcattctct agtgaaaaac cttgttggca      600

taaaaaggct aattgatttt cgagagtttc atactgtttt tctgtaggcc gtgtacctaa      660

atgtactttt gctccatcgc gatgacttag taaagcacat ctaaaacttt tagcgttatt      720

acgtaaaaaa tcttgccagc tttccccttc taaagggcaa aagtgagtat ggtgcctatc      780

taacatctca atggctaagg cgtcgagcaa agcccgctta ttttttacat gccaatacaa      840

tgtaggctgc tctacaccta gcttctgggc gagtttacgg gttgttaaac cttcgattcc      900

gacctcatta agcagctcta atgcgctgtt aatcacttta cttttatcta atctagacat      960

cattaattcc taatttttgt tgacactcta tcattgatag agttatttta ccactcccta     1020

tcagtgatag agaaaatgaa aggaggtaaa ttatgagcaa caatgccttg cagactatta     1080

ttaacgctcg tcttcccggc gaagaaggtc tgtggcaaat ccatcttcag gatggtaaga     1140

tttctgccat tgatgcccaa agcggggtga tgccaatcac ggaaaattca ctggatgcag     1200

aacagggctt ggtaattccg ccttttgtag aaccacacat ccatttggat actacccaga     1260

cggcgggtca acccaactgg aaccagagcg gtacgctttt cgaagggatc gagcgctggg     1320

ccgaacgtaa agctcttttg acacatgacg acgtaaagca acgcgcgtgg cagacactga     1380

aatggcaaat tgccaatggg attcagcatg tacgcacgca cgtggacgtt agcgacgcga     1440

ccctgaccgc attaaaggcc atgttggaag tgaagcaaga agtggcccct tggatcgatc     1500

tgcaaattgt agcttttcca caagagggta tccttagcta cccgaacgga gaagctcttt     1560

tagaggaagc gctgcgcttg ggcgctgacg ttgtcggtgc tattcctcac tttgagttta     1620

cacgcgagta tggagttgag tcgcttcata agacgttcgc tttggcccag aaatacgacc     1680

gtttaattga cgtacattgc gatgagatcg acgacgagca atcccgcttt gtagaaacag     1740

tcgccgcgtt ggcgcatcac gaaggcatgg gtgcgcgcgt aaccgcctcg cacactactg     1800

ctatgcactc gtacaacgga gcgtatacta gccgcctgtt tcgcttgctg aaaatgagtg     1860

gcattaactt tgttgccaac ccattggtca atatccattt gcaaggtcgt ttcgatacat     1920

atccaaaacg tcgtggcatc acccgtgtca aagagatgct ggagtctggc attaatgtgt     1980

gttttggaca tgacgatgta ttcgatccat ggtatccgct tggcacggct aacatgttac     2040

aagtgttgca catggggttg catgtgtgcc agttaatggg ctacggtcag atcaatgatg     2100

gcttaaactt aatcacacac cactccgcgc gcactctgaa tttgcaagac tacggcatcg     2160

cagcaggtaa ctcggccaac ctgatcatct tacccgcaga aaacggcttt gatgctttgc     2220

gccgtcaggt gccggtccgc tatagtgtgc gtggtgggaa ggttatcgcg tccacccaac     2280

cagcacagac cactgtgtac cttgaacagc ccgaagctat cgactacaaa cgctaaaagg     2340

gcgaattctg cagatatcca tcacactggc ggccgctcga gcatgcatct agagggccca     2400

attcgcccta tagtgagtcg tattacaatt cactggccgt cgttttacaa cgtcgtgact     2460

gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct     2520

ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctatacg     2580

tacggcagtt taaggtttac acctataaaa gagagagccg ttatcgtctg tttgtggatg     2640

tacagagtga tattattgac acgccggggc gacggatggt gatccccctg gccagtgcac     2700

gtctgctgtc agataaagtc tcccgtgaac tttacccggt ggtgcatatc ggggatgaaa     2760

gctggcgcat gatgaccacc gatatggcca gtgtgccggt ctccgttatc ggggaagaag     2820

tggctgatct cagccaccgc gaaaatgaca tcaaaaacgc cattaacctg atgttctggg     2880

gaatataaat gtcaggcatg agattatcaa aaaggatctt cacctagatc cttttcacgt     2940

agaaagccag tccgcagaaa cggtgctgac cccggatgaa tgtcagctac tgggctatct     3000

ggacaaggga aaacgcaagc gcaaagagaa agcaggtagc ttgcagtggg cttacatggc     3060

gatagctaga ctgggcggtt ttatggacag caagcgaacc ggaattgcca gctggggcgc     3120

cctctggtaa ggttgggaag ccctgcaaag taaactggat ggctttctcg ccgccaagga     3180

tctgatggcg caggggatca agctctgatc aagagacagg atgaggatcg tttcgcatga     3240

ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg ctattcggct     3300

atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc     3360

aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat gaactgcaag     3420

acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca gctgtgctcg     3480

acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg gggcaggatc     3540

tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat gcaatgcggc     3600

ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa catcgcatcg     3660

agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg gacgaagagc     3720

atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgagcatg cccgacggcg     3780

aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc     3840

gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat caggacatag     3900

cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac cgcttcctcg     3960

tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc cttcttgacg     4020

agttcttctg aattattaac gcttacaatt tcctgatgcg gtattttctc cttacgcatc     4080

tgtgcggtat ttcacaccgc atacaggtgg cacttttcgg ggaaatgtgc gcggaacccc     4140

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg     4200

ataaatgctt caataatagc acgtgaggag ggccaccatg gccaagttga ccagtgccgt     4260

tccggtgctc accgcgcgcg acgtcgccgg agcggtcgag ttctggaccg accggctcgg     4320

gttctcccgg gacttcgtgg aggacgactt cgccggtgtg gtccgggacg acgtgaccct     4380

gttcatcagc gcggtccagg accaggtggt gccggacaac accctggcct gggtgtgggt     4440

gcgcggcctg gacgagctgt acgccgagtg gtcggaggtc gtgtccacga acttccggga     4500

cgcctccggg ccggccatga ccgagatcgg cgagcagccg tgggggcggg agttcgccct     4560

gcgcgacccg gccggcaact gcgtgcactt cgtggccgag gagcaggact gacacgtgct     4620

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     4680

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     4740

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     4800

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     4860

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     4920

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     4980

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     5040

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     5100

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     5160

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     5220

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     5280

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     5340

cgccagcaac gcggcctttt tacggttcct gggcttttgc tggccttttg ctcacatgtt     5400

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     5460

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaag      5519


<210> 1213
<211> 1281
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1213
atgagcaaca atgccttgca gactattatt aacgctcgtc ttcccggcga agaaggtctg       60

tggcaaatcc atcttcagga tggtaagatt tctgccattg atgcccaaag cggggtgatg      120

ccaatcacgg aaaattcact ggatgcagaa cagggcttgg taattccgcc ttttgtagaa      180

ccacacatcc atttggatac tacccagacg gcgggtcaac ccaactggaa ccagagcggt      240

acgcttttcg aagggatcga gcgctgggcc gaacgtaaag ctcttttgac acatgacgac      300

gtaaagcaac gcgcgtggca gacactgaaa tggcaaattg ccaatgggat tcagcatgta      360

cgcacgcacg tggacgttag cgacgcgacc ctgaccgcat taaaggccat gttggaagtg      420

aagcaagaag tggccccttg gatcgatctg caaattgtag cttttccaca agagggtatc      480

cttagctacc cgaacggaga agctctttta gaggaagcgc tgcgcttggg cgctgacgtt      540

gtcggtgcta ttcctcactt tgagtttaca cgcgagtatg gagttgagtc gcttcataag      600

acgttcgctt tggcccagaa atacgaccgt ttaattgacg tacattgcga tgagatcgac      660

gacgagcaat cccgctttgt agaaacagtc gccgcgttgg cgcatcacga aggcatgggt      720

gcgcgcgtaa ccgcctcgca cactactgct atgcactcgt acaacggagc gtatactagc      780

cgcctgtttc gcttgctgaa aatgagtggc attaactttg ttgccaaccc attggtcaat      840

atccatttgc aaggtcgttt cgatacatat ccaaaacgtc gtggcatcac ccgtgtcaaa      900

gagatgctgg agtctggcat taatgtgtgt tttggacatg acgatgtatt cgatccatgg      960

tatccgcttg gcacggctaa catgttacaa gtgttgcaca tggggttgca tgtgtgccag     1020

ttaatgggct acggtcagat caatgatggc ttaaacttaa tcacacacca ctccgcgcgc     1080

actctgaatt tgcaagacta cggcatcgca gcaggtaact cggccaacct gatcatctta     1140

cccgcagaaa acggctttga tgctttgcgc cgtcaggtgc cggtccgcta tagtgtgcgt     1200

ggtgggaagg ttatcgcgtc cacccaacca gcacagacca ctgtgtacct tgaacagccc     1260

gaagctatcg actacaaacg c                                               1281


<210> 1214
<211> 4894
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1214
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttt      900

aagacccact ttcacattta agttgttttt ctaatccgca tatgatcaat tcaaggccga      960

ataagaaggc tggctctgca ccttggtgat caaataattc gatagcttgt cgtaataatg     1020

gcggcatact atcagtagta ggtgtttccc tttcttcttt agcgacttga tgctcttgat     1080

cttccaatac gcaacctaaa gtaaaatgcc ccacagcgct gagtgcatat aatgcattct     1140

ctagtgaaaa accttgttgg cataaaaagg ctaattgatt ttcgagagtt tcatactgtt     1200

tttctgtagg ccgtgtacct aaatgtactt ttgctccatc gcgatgactt agtaaagcac     1260

atctaaaact tttagcgtta ttacgtaaaa aatcttgcca gctttcccct tctaaagggc     1320

aaaagtgagt atggtgccta tctaacatct caatggctaa ggcgtcgagc aaagcccgct     1380

tattttttac atgccaatac aatgtaggct gctctacacc tagcttctgg gcgagtttac     1440

gggttgttaa accttcgatt ccgacctcat taagcagctc taatgcgctg ttaatcactt     1500

tacttttatc taatctagac atcattaatt cctaattttt gttgacactc tatcattgat     1560

agagttattt taccactccc tatcagtgat agagaaaagt gaacttcact tattagggag     1620

gaaagaatat gtcaaataac gctctgcaga ctattataaa tgctcgattg ccaggggaag     1680

aggggttgtg gcaaattcac cttcaggatg ggaagatctc tgcgatagat gcgcagtcgg     1740

gcgtgatgcc aatcactgaa aactctctcg acgcggaaca gggcctggtt attcctccgt     1800

ttgttgagcc acacattcac cttgatacta cgcagacggc aggtcagccc aattggaatc     1860

agtctggtac cttgtttgag gggatagagc ggtgggccga acgtaaggca ttgctgaccc     1920

acgatgatgt caaacagcgc gcttggcaga ctttaaagtg gcaaattgcg aatggcatcc     1980

agcatgttag aacacacgtg gatgtgtcgg atgctactct gacggctctg aaagcgatgc     2040

ttgaagttaa gcaggaggtt gccccgtgga tcgatctgca aattgttgca ttcccgcagg     2100

agggcatcct cagctatccg aacggtgagg cgcttctcga agaagctctc agacttggag     2160

cggacgttgt gggcgcgatc ccgcatttcg aattcactcg cgagtacggt gtggaatcac     2220

ttcacaaaac ctttgcgctg gcacagaagt atgaccgact tattgatgta cattgcgatg     2280

aaatagatga tgagcagtcc agattcgttg aaaccgttgc agcgttggct catcacgagg     2340

gcatgggcgc acgcgtcact gcctcccaca cgaccgcgat gcattcgtat aacggtgcat     2400

acacctcacg cctgtttcgg ctgttaaaaa tgagcggaat aaacttcgtc gctaatccat     2460

tggttaatat tcatttgcag ggtcgctttg atacgtatcc aaaaagacgc ggcataacgc     2520

gagtcaaaga aatgctggag agtggtatca atgtgtgctt tggccacgat gatgttttcg     2580

atccctggta tccgcttgga acggcgaata tgcttcaggt tctgcacatg gggctgcacg     2640

tgtgccagct gatgggttac ggacaaatta acgatggcct gaatctcatc acccatcatt     2700

ctgcccgaac tcttaacctg caggattatg gaattgcggc gggcaattct gctaatctga     2760

taatactgcc tgctgaaaac ggtttcgacg cgctccgccg acaagtgccc gttcgttaca     2820

gtgttcgagg cggcaaagtc atcgcgtcaa ctcaaccagc tcaaactact gtatatctgg     2880

aacagcccga agctattgac tacaaacgag gctcagatta taaggacgat gatgataaag     2940

gtagcaaaat agttgaagtt aaacatcccc tcgttaaaca caaactgggc ttgatgcgcg     3000

aacaggacat atcgaccaaa cgcttccgtg aactggcttc agaagtgggc tcactactga     3060

cgtatgaagc aaccgcagat cttgagacag aaaaagtaac tattgaaggc tggaatggcc     3120

ccgtagagat agatcagatc aaaggtaaaa aaattacggt cgttccgatt ttgcgcgccg     3180

ggctgggcat gatggatgga gtgttagaaa acgtcccatc cgcccggatc tcggtggtcg     3240

gaatgtaccg caacgaagag acgcttgaac cagtccctta cttccagaag ttggttagta     3300

acatagacga acgaatggcc ttaatagtag atccgatgct cgcgactggc ggcagcgtga     3360

tcgctacgat tgatctgttg aaaaaagcgg ggtgtagttc tatcaaagtt ctggttctcg     3420

tcgcggcgcc agaaggtatt gccgcgttag aaaaagcaca tccggacgtc gaactgtaca     3480

ctgcatctat tgaccaggga ttgaacgagc atggatatat aattccgggc ttgggcgatg     3540

cgggagataa aatcttcggt actaagtaag gaggaacgat tggtaaaccc ggtgaacgca     3600

tgagaaagcc cccggaagat caccttccgg gggctttttt attgcgcgga ccaaaacgaa     3660

aaaagacgct cgaaagcgtc tcttttctgg aatttggtac cgaggcgtaa tgctctgcca     3720

gtgttacaac caattaacca attctgatta gaaaaactca tcgagcatca aatgaaactg     3780

caatttattc atatcaggat tatcaatacc atatttttga aaaagccgtt tctgtaatga     3840

aggagaaaac tcaccgaggc agttccatag gatggcaaga tcctggtatc ggtctgcgat     3900

tccgactcgt ccaacatcaa tacaacctat taatttcccc tcgtcaaaaa taaggttatc     3960

aagtgagaaa tcaccatgag tgacgactga atccggtgag aatggcaaaa gcttatgcat     4020

ttctttccag acttgttcaa caggccagcc attacgctcg tcatcaaaat cactcgcatc     4080

aaccaaaccg ttattcattc gtgattgcgc ctgagcgaga cgaaatacgc gatcgctgtt     4140

aaaaggacaa ttacaaacag gaatcgaatg caaccggcgc aggaacactg ccagcgcatc     4200

aacaatattt tcacctgaat caggatattc ttctaatacc tggaatgctg ttttcccggg     4260

gatcgcagtg gtgagtaacc atgcatcatc aggagtacgg ataaaatgct tgatggtcgg     4320

aagaggcata aattccgtca gccagtttag tctgaccatc tcatctgtaa catcattggc     4380

aacgctacct ttgccatgtt tcagaaacaa ctctggcgca tcgggcttcc catacaatcg     4440

atagattgtc gcacctgatt gcccgacatt atcgcgagcc catttatacc catataaatc     4500

agcatccatg ttggaattta atcgcggcct cgagcaagac gtttcccgtt gaatatggct     4560

cataacaccc cttgtattac tgtttatgta agcagacagt tttattgttc atgatgatat     4620

atttttatct tgtgcaatgt aacatcagag attttgagac acaacgtggc tttgttgaat     4680

aaatcgaact tttgctgagt tgaaggatca gatcacgcat cttcccgaca acgcagaccg     4740

ttccgtggca aagcaaaagt tcaaaatcac caactggtcc acctacaaca aagctctcat     4800

caaccgtggc tccctcactt tctggctgga tgatggggcg attcaggcct ggtatgagtc     4860

agcaacacct tcttcacgag gcagacctca gcgc                                 4894


<210> 1215
<211> 1941
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1215
atgtcaaata acgctctgca gactattata aatgctcgat tgccagggga agaggggttg       60

tggcaaattc accttcagga tgggaagatc tctgcgatag atgcgcagtc gggcgtgatg      120

ccaatcactg aaaactctct cgacgcggaa cagggcctgg ttattcctcc gtttgttgag      180

ccacacattc accttgatac tacgcagacg gcaggtcagc ccaattggaa tcagtctggt      240

accttgtttg aggggataga gcggtgggcc gaacgtaagg cattgctgac ccacgatgat      300

gtcaaacagc gcgcttggca gactttaaag tggcaaattg cgaatggcat ccagcatgtt      360

agaacacacg tggatgtgtc ggatgctact ctgacggctc tgaaagcgat gcttgaagtt      420

aagcaggagg ttgccccgtg gatcgatctg caaattgttg cattcccgca ggagggcatc      480

ctcagctatc cgaacggtga ggcgcttctc gaagaagctc tcagacttgg agcggacgtt      540

gtgggcgcga tcccgcattt cgaattcact cgcgagtacg gtgtggaatc acttcacaaa      600

acctttgcgc tggcacagaa gtatgaccga cttattgatg tacattgcga tgaaatagat      660

gatgagcagt ccagattcgt tgaaaccgtt gcagcgttgg ctcatcacga gggcatgggc      720

gcacgcgtca ctgcctccca cacgaccgcg atgcattcgt ataacggtgc atacacctca      780

cgcctgtttc ggctgttaaa aatgagcgga ataaacttcg tcgctaatcc attggttaat      840

attcatttgc agggtcgctt tgatacgtat ccaaaaagac gcggcataac gcgagtcaaa      900

gaaatgctgg agagtggtat caatgtgtgc tttggccacg atgatgtttt cgatccctgg      960

tatccgcttg gaacggcgaa tatgcttcag gttctgcaca tggggctgca cgtgtgccag     1020

ctgatgggtt acggacaaat taacgatggc ctgaatctca tcacccatca ttctgcccga     1080

actcttaacc tgcaggatta tggaattgcg gcgggcaatt ctgctaatct gataatactg     1140

cctgctgaaa acggtttcga cgcgctccgc cgacaagtgc ccgttcgtta cagtgttcga     1200

ggcggcaaag tcatcgcgtc aactcaacca gctcaaacta ctgtatatct ggaacagccc     1260

gaagctattg actacaaacg aggctcagat tataaggacg atgatgataa aggtagcaaa     1320

atagttgaag ttaaacatcc cctcgttaaa cacaaactgg gcttgatgcg cgaacaggac     1380

atatcgacca aacgcttccg tgaactggct tcagaagtgg gctcactact gacgtatgaa     1440

gcaaccgcag atcttgagac agaaaaagta actattgaag gctggaatgg ccccgtagag     1500

atagatcaga tcaaaggtaa aaaaattacg gtcgttccga ttttgcgcgc cgggctgggc     1560

atgatggatg gagtgttaga aaacgtccca tccgcccgga tctcggtggt cggaatgtac     1620

cgcaacgaag agacgcttga accagtccct tacttccaga agttggttag taacatagac     1680

gaacgaatgg ccttaatagt agatccgatg ctcgcgactg gcggcagcgt gatcgctacg     1740

attgatctgt tgaaaaaagc ggggtgtagt tctatcaaag ttctggttct cgtcgcggcg     1800

ccagaaggta ttgccgcgtt agaaaaagca catccggacg tcgaactgta cactgcatct     1860

attgaccagg gattgaacga gcatggatat ataattccgg gcttgggcga tgcgggagat     1920

aaaatcttcg gtactaagta a                                               1941


<210> 1216
<211> 427
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1216
Met Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn Ala Arg Leu Pro Gly 
1               5                   10                  15      


Glu Glu Gly Leu Trp Gln Ile His Leu Gln Asp Gly Lys Ile Ser Ala 
            20                  25                  30          


Ile Asp Ala Gln Ser Gly Val Met Pro Ile Thr Glu Asn Ser Leu Asp 
        35                  40                  45              


Ala Glu Gln Gly Leu Val Ile Pro Pro Phe Val Glu Pro His Ile His 
    50                  55                  60                  


Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn Trp Asn Gln Ser Gly 
65                  70                  75                  80  


Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu Arg Lys Ala Leu Leu 
                85                  90                  95      


Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln Thr Leu Lys Trp Gln 
            100                 105                 110         


Ile Ala Asn Gly Ile Gln His Val Arg Thr His Val Asp Val Ser Asp 
        115                 120                 125             


Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu Val Lys Gln Glu Val 
    130                 135                 140                 


Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe Pro Gln Glu Gly Ile 
145                 150                 155                 160 


Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu Glu Ala Leu Arg Leu 
                165                 170                 175     


Gly Ala Asp Val Val Gly Ala Ile Pro His Phe Glu Phe Thr Arg Glu 
            180                 185                 190         


Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala Leu Ala Gln Lys Tyr 
        195                 200                 205             


Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile Asp Asp Glu Gln Ser 
    210                 215                 220                 


Arg Phe Val Glu Thr Val Ala Ala Leu Ala His His Glu Gly Met Gly 
225                 230                 235                 240 


Ala Arg Val Thr Ala Ser His Thr Thr Ala Met His Ser Tyr Asn Gly 
                245                 250                 255     


Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys Met Ser Gly Ile Asn 
            260                 265                 270         


Phe Val Ala Asn Pro Leu Val Asn Ile His Leu Gln Gly Arg Phe Asp 
        275                 280                 285             


Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val Lys Glu Met Leu Glu 
    290                 295                 300                 


Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp Val Phe Asp Pro Trp 
305                 310                 315                 320 


Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val Leu His Met Gly Leu 
                325                 330                 335     


His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile Asn Asp Gly Leu Asn 
            340                 345                 350         


Leu Ile Thr His His Ser Ala Arg Thr Leu Asn Leu Gln Asp Tyr Gly 
        355                 360                 365             


Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile Leu Pro Ala Glu Asn 
    370                 375                 380                 


Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val Arg Tyr Ser Val Arg 
385                 390                 395                 400 


Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala Gln Thr Thr Val Tyr 
                405                 410                 415     


Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg 
            420                 425         


<210> 1217
<211> 646
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1217
Met Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn Ala Arg Leu Pro Gly 
1               5                   10                  15      


Glu Glu Gly Leu Trp Gln Ile His Leu Gln Asp Gly Lys Ile Ser Ala 
            20                  25                  30          


Ile Asp Ala Gln Ser Gly Val Met Pro Ile Thr Glu Asn Ser Leu Asp 
        35                  40                  45              


Ala Glu Gln Gly Leu Val Ile Pro Pro Phe Val Glu Pro His Ile His 
    50                  55                  60                  


Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn Trp Asn Gln Ser Gly 
65                  70                  75                  80  


Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu Arg Lys Ala Leu Leu 
                85                  90                  95      


Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln Thr Leu Lys Trp Gln 
            100                 105                 110         


Ile Ala Asn Gly Ile Gln His Val Arg Thr His Val Asp Val Ser Asp 
        115                 120                 125             


Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu Val Lys Gln Glu Val 
    130                 135                 140                 


Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe Pro Gln Glu Gly Ile 
145                 150                 155                 160 


Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu Glu Ala Leu Arg Leu 
                165                 170                 175     


Gly Ala Asp Val Val Gly Ala Ile Pro His Phe Glu Phe Thr Arg Glu 
            180                 185                 190         


Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala Leu Ala Gln Lys Tyr 
        195                 200                 205             


Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile Asp Asp Glu Gln Ser 
    210                 215                 220                 


Arg Phe Val Glu Thr Val Ala Ala Leu Ala His His Glu Gly Met Gly 
225                 230                 235                 240 


Ala Arg Val Thr Ala Ser His Thr Thr Ala Met His Ser Tyr Asn Gly 
                245                 250                 255     


Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys Met Ser Gly Ile Asn 
            260                 265                 270         


Phe Val Ala Asn Pro Leu Val Asn Ile His Leu Gln Gly Arg Phe Asp 
        275                 280                 285             


Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val Lys Glu Met Leu Glu 
    290                 295                 300                 


Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp Val Phe Asp Pro Trp 
305                 310                 315                 320 


Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val Leu His Met Gly Leu 
                325                 330                 335     


His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile Asn Asp Gly Leu Asn 
            340                 345                 350         


Leu Ile Thr His His Ser Ala Arg Thr Leu Asn Leu Gln Asp Tyr Gly 
        355                 360                 365             


Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile Leu Pro Ala Glu Asn 
    370                 375                 380                 


Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val Arg Tyr Ser Val Arg 
385                 390                 395                 400 


Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala Gln Thr Thr Val Tyr 
                405                 410                 415     


Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg Gly Ser Asp Tyr Lys 
            420                 425                 430         


Asp Asp Asp Asp Lys Gly Ser Lys Ile Val Glu Val Lys His Pro Leu 
        435                 440                 445             


Val Lys His Lys Leu Gly Leu Met Arg Glu Gln Asp Ile Ser Thr Lys 
    450                 455                 460                 


Arg Phe Arg Glu Leu Ala Ser Glu Val Gly Ser Leu Leu Thr Tyr Glu 
465                 470                 475                 480 


Ala Thr Ala Asp Leu Glu Thr Glu Lys Val Thr Ile Glu Gly Trp Asn 
                485                 490                 495     


Gly Pro Val Glu Ile Asp Gln Ile Lys Gly Lys Lys Ile Thr Val Val 
            500                 505                 510         


Pro Ile Leu Arg Ala Gly Leu Gly Met Met Asp Gly Val Leu Glu Asn 
        515                 520                 525             


Val Pro Ser Ala Arg Ile Ser Val Val Gly Met Tyr Arg Asn Glu Glu 
    530                 535                 540                 


Thr Leu Glu Pro Val Pro Tyr Phe Gln Lys Leu Val Ser Asn Ile Asp 
545                 550                 555                 560 


Glu Arg Met Ala Leu Ile Val Asp Pro Met Leu Ala Thr Gly Gly Ser 
                565                 570                 575     


Val Ile Ala Thr Ile Asp Leu Leu Lys Lys Ala Gly Cys Ser Ser Ile 
            580                 585                 590         


Lys Val Leu Val Leu Val Ala Ala Pro Glu Gly Ile Ala Ala Leu Glu 
        595                 600                 605             


Lys Ala His Pro Asp Val Glu Leu Tyr Thr Ala Ser Ile Asp Gln Gly 
    610                 615                 620                 


Leu Asn Glu His Gly Tyr Ile Ile Pro Gly Leu Gly Asp Ala Gly Asp 
625                 630                 635                 640 


Lys Ile Phe Gly Thr Lys 
                645     


<210> 1218
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1218
Met Lys Arg His Leu Asn Thr Ser Tyr Arg Leu Val Trp Asn His Ile 
1               5                   10                  15      


Thr Gly Ala Phe Val Val Ala Ser Glu Leu Ala Arg Ala Arg Gly Lys 
            20                  25                  30          


Arg Ala Gly Val Ala Val Ala Leu Ser Leu Ala Ala Ala Thr Ser Leu 
        35                  40                  45              


Pro Ala Leu Ala 
    50          


<210> 1219
<211> 53
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1219
Met Asn Lys Ile Phe Lys Val Ile Trp Asn Pro Ala Thr Gly Ser Tyr 
1               5                   10                  15      


Thr Val Ala Ser Glu Thr Ala Lys Ser Arg Gly Lys Lys Ser Gly Arg 
            20                  25                  30          


Ser Lys Leu Leu Ile Ser Ala Leu Val Ala Gly Gly Leu Leu Ser Ser 
        35                  40                  45              


Phe Gly Ala Ser Ala 
    50              


<210> 1220
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1220
Met Gln Leu Arg Lys Pro Ala Thr Ala Ile Leu Ala Leu Ala Leu Ser 
1               5                   10                  15      


Ala Gly Leu Ala Gln Ala 
            20          


<210> 1221
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1221
Met Phe Trp Arg Asp Met Thr Leu Ser Val Trp Arg Lys Lys Thr Thr 
1               5                   10                  15      


Gly Leu Lys Thr Lys Lys Arg Leu Leu Ala Leu Val Leu Ala Ala Ala 
            20                  25                  30          


Leu Cys Ser Ser Pro Val Trp Ala 
        35                  40  


<210> 1222
<211> 159
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1222
atgaacaaga ttttcaaggt tatctggaac cccgcgacag gcagctacac tgtggcctcc       60

gaaaccgcta agtcgcgcgg caagaagtca ggacgttcaa agctgcttat ttctgcttta      120

gtagccggag gattactttc tagctttgga gcctcggca                             159


<210> 1223
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1223
atgaaaaaaa tctggctggc attagcaggc ttagtcctgg cctttagtgc ctcggca          57


<210> 1224
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1224
atgcagttgc gcaagcctgc cacggcaatt ttagcattag ctctttctgc gggcttggcc       60

caggca                                                                  66


<210> 1225
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1225
atgttctggc gcgacatgac actgagcgtt tggcgtaaaa aaacaacggg actgaaaacc       60

aaaaagcgtt tgttagccct tgtcctggcg gcagccctgt gctcgtcccc ggtatgggca      120


<210> 1226
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1226
atgggataca agatgaacat ttcatcactt cgcaaagctt ttatcttcat gggtgccgtt       60

gctgctctgt cactggtcaa tgctcaatcg gccctggca                              99


<210> 1227
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1227
atgaagatta aaacaggcgc tcgtattttg gccctgtctg cgcttacgac tatgatgttt       60

agtgcctcgg ccctggca                                                     78


<210> 1228
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1228
atgacgaata tcactaaacg tagccttgtg gccgcggggg tcttggctgc attgatggct       60

ggcaatgttg ctctggca                                                     78


<210> 1229
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1229
atgaaatatc tgttgcccac ggctgccgcg ggtctgctgc tgctggcagc gcaaccggct       60

atggca                                                                  66


<210> 1230
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1230
atgaagcaaa gtacgatcgc ccttgcgctg ttgccccttc ttttcacgcc cgtcaccaag       60

gca                                                                     63


<210> 1231
<211> 343
<212> PRT
<213> Homo sapiens

<400> 1231
Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr 
            340             


<210> 1232
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1232
aactgggtga atgtcatctc ggacttaaag aagattgaag acttgattca gagcatgcat       60

atcgacgcga ctttatacac cgagtctgac gtacacccaa gttgcaaggt caccgccatg      120

aagtgcttct tgcttgagtt acaagtcatc agtttggaat ctggagacgc tagtattcac      180

gatacggtgg aaaacctgat catccttgca aatgactctc tttcatccaa tggtaatgtt      240

actgagtcgg ggtgcaaaga atgtgaagaa cttgaggaga agaacattaa ggaatttctt      300

cagtcattcg tgcatatcgt acagatgttc atcaacacct ct                         342


<210> 1233
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1233
tccggaggga gcggcggcgg gggtagtgga ggcgggtcag gcggcggggg ctcacttcag       60


<210> 1234
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1234
gattataaag acgatgacga taagatcgaa ggacgt                                 36


<210> 1235
<211> 1791
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1235
atggggtaca aaatgaacat tagctcgctt cgcaaagcat tcatttttat gggggctgtt       60

gcagctttaa gccttgtcaa tgcccagtca gcgcttgccg tcgactataa ggatgacgac      120

gacaagcaat tgggcggtgg catctgggag cttaagaagg acgtgtatgt agtggagtta      180

gactggtatc cagatgcccc cggagagatg gtggtcttaa catgtgacac tccagaggag      240

gacgggatta cctggacact tgaccagtca agcgaggtat tgggttctgg aaagacgctt      300

actattcaag tcaaagaatt tggggatgcc gggcagtata catgtcacaa gggcggcgaa      360

gttctgtcgc actccttact tttgttacac aaaaaagaag acggcatttg gtccacagac      420

atccttaagg accaaaagga gccgaagaat aagacgtttc tgcgctgtga agcgaagaac      480

tatagtggtc gctttacttg ctggtggttg acgaccattt ccactgattt aaccttttcg      540

gtaaagagtt ctcgcgggag ttccgaccca cagggcgtga cttgtggcgc agccacactt      600

tcggcggaac gcgttcgtgg ggacaataag gaatacgaat attcggtcga gtgtcaggaa      660

gattcagctt gccctgccgc tgaggagtca cttccgattg aagtgatggt tgacgccgtg      720

cacaaattaa agtatgaaaa ttacacgtca tctttcttta tccgtgacat tattaagccc      780

gacccgccaa agaatctgca gcttaaaccc ctgaagaaca gccgccaggt ggaagtaagc      840

tgggaatatc ctgacacctg gtccactccg cattcgtatt tctcgttgac gttttgtgtt      900

caggtgcagg gaaagagcaa gcgcgaaaag aaggatcgcg tctttacaga caaaacgtcc      960

gcgacggtta tttgtcgtaa gaatgctagt atctctgttc gcgctcagga ccgttattac     1020

tcatctagtt ggtcggagtg ggcctcggtt ccctgctctg ggggtggagg atcgggtgga     1080

ggtggctcgg gaggtggcgg ctcccgtaat ttaccggtgg ctactcctga cccagggatg     1140

ttcccgtgct tgcaccatag ccaaaactta cttcgcgctg tcagcaacat gcttcagaaa     1200

gcacgtcaaa cgcttgagtt ttacccgtgt actagcgaag agatcgatca cgaggacatt     1260

accaaagaca aaacctccac cgtcgaggcc tgccttccac ttgaactgac gaaaaatgag     1320

tcatgcttaa attctcgtga aacctccttc attactaacg gatcgtgcct ggcctcgcgc     1380

aagacttcgt tcatgatggc attatgcttg tcgtctattt atgaagacct taaaatgtat     1440

caagtggagt tcaagacgat gaatgcaaaa cttcttatgg acccgaagcg tcaaatcttc     1500

ttagaccaaa acatgttggc cgtgatcgat gaactgatgc aagccttgaa ttttaattcg     1560

gaaactgtac cgcaaaaatc ttctcttgaa gaaccggatt tctataagac caaaattaaa     1620

ctttgtattt tacttcacgc tttccgcatc cgtgcagtaa ctatcgaccg cgtaatgagt     1680

taccttaacg cctcgggtgg cgagctcggt ggcagtggta agcctatccc taaccctctc     1740

ctcggcctcg attctacggg atccggtcat caccaccatc accatcacca t              1791


<210> 1236
<211> 69
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1236
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu 
65                  


<210> 1237
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1237
atgtttaagt ctacacttgc agccatggcc gcagtcttcg cactgtcagc cttgagtcct       60

gctgcaatgg ca                                                           72


<210> 1238
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1238
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210> 1239
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1239
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210> 1240
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1240
Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210> 1241
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1241
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210> 1242
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MISC_FEATURE
<222> (1)..(30) 
<223> /note="This sequence may encompass 1-6 'Gly Gly Gly Gly Ser'
      repeating units"

<400> 1242
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 1243
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1243
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 1244
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1244
Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210> 1245
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1245
Gly Gly Gly Gly Ser 
1               5   


<210> 1246
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1246
wntgaatwww wattcanw                                                     18


<210> 1247
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1247
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 1248
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (6)..(6) 
<223> 1,3 dimethyl-His

<400> 1248
Cys Ala Val Ala Tyr His 
1               5       


<210> 1249
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1249
ttgttgayry rtcaacwa                                                     18


<210> 1250
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1250
ggaaaatttt tttaaaaaaa aaac                                              24


<210> 1251
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1251
Ala Gly Tyr Gly Ser Thr Leu Thr 
1               5               


<210> 1252
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 1252
His His His His His His 
1               5       


<210> 1253
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1253
atgaagaaaa tttggctggc acttgccggt ttggtattag cgttttccgc ctcggca          57


<210> 1254
<211> 522
<212> PRT
<213> Homo sapiens

<400> 1254
Met Gln Pro Trp His Gly Lys Ala Met Gln Arg Ala Ser Glu Ala Gly 
1               5                   10                  15      


Ala Thr Ala Pro Lys Ala Ser Ala Arg Asn Ala Arg Gly Ala Pro Met 
            20                  25                  30          


Asp Pro Thr Glu Ser Pro Ala Ala Pro Glu Ala Ala Leu Pro Lys Ala 
        35                  40                  45              


Gly Lys Phe Gly Pro Ala Arg Lys Ser Gly Ser Arg Gln Lys Lys Ser 
    50                  55                  60                  


Ala Pro Asp Thr Gln Glu Arg Pro Pro Val Arg Ala Thr Gly Ala Arg 
65                  70                  75                  80  


Ala Lys Lys Ala Pro Gln Arg Ala Gln Asp Thr Gln Pro Ser Asp Ala 
                85                  90                  95      


Thr Ser Ala Pro Gly Ala Glu Gly Leu Glu Pro Pro Ala Ala Arg Glu 
            100                 105                 110         


Pro Ala Leu Ser Arg Ala Gly Ser Cys Arg Gln Arg Gly Ala Arg Cys 
        115                 120                 125             


Ser Thr Lys Pro Arg Pro Pro Pro Gly Pro Trp Asp Val Pro Ser Pro 
    130                 135                 140                 


Gly Leu Pro Val Ser Ala Pro Ile Leu Val Arg Arg Asp Ala Ala Pro 
145                 150                 155                 160 


Gly Ala Ser Lys Leu Arg Ala Val Leu Glu Lys Leu Lys Leu Ser Arg 
                165                 170                 175     


Asp Asp Ile Ser Thr Ala Ala Gly Met Val Lys Gly Val Val Asp His 
            180                 185                 190         


Leu Leu Leu Arg Leu Lys Cys Asp Ser Ala Phe Arg Gly Val Gly Leu 
        195                 200                 205             


Leu Asn Thr Gly Ser Tyr Tyr Glu His Val Lys Ile Ser Ala Pro Asn 
    210                 215                 220                 


Glu Phe Asp Val Met Phe Lys Leu Glu Val Pro Arg Ile Gln Leu Glu 
225                 230                 235                 240 


Glu Tyr Ser Asn Thr Arg Ala Tyr Tyr Phe Val Lys Phe Lys Arg Asn 
                245                 250                 255     


Pro Lys Glu Asn Pro Leu Ser Gln Phe Leu Glu Gly Glu Ile Leu Ser 
            260                 265                 270         


Ala Ser Lys Met Leu Ser Lys Phe Arg Lys Ile Ile Lys Glu Glu Ile 
        275                 280                 285             


Asn Asp Ile Lys Asp Thr Asp Val Ile Met Lys Arg Lys Arg Gly Gly 
    290                 295                 300                 


Ser Pro Ala Val Thr Leu Leu Ile Ser Glu Lys Ile Ser Val Asp Ile 
305                 310                 315                 320 


Thr Leu Ala Leu Glu Ser Lys Ser Ser Trp Pro Ala Ser Thr Gln Glu 
                325                 330                 335     


Gly Leu Arg Ile Gln Asn Trp Leu Ser Ala Lys Val Arg Lys Gln Leu 
            340                 345                 350         


Arg Leu Lys Pro Phe Tyr Leu Val Pro Lys His Ala Lys Glu Gly Asn 
        355                 360                 365             


Gly Phe Gln Glu Glu Thr Trp Arg Leu Ser Phe Ser His Ile Glu Lys 
    370                 375                 380                 


Glu Ile Leu Asn Asn His Gly Lys Ser Lys Thr Cys Cys Glu Asn Lys 
385                 390                 395                 400 


Glu Glu Lys Cys Cys Arg Lys Asp Cys Leu Lys Leu Met Lys Tyr Leu 
                405                 410                 415     


Leu Glu Gln Leu Lys Glu Arg Phe Lys Asp Lys Lys His Leu Asp Lys 
            420                 425                 430         


Phe Ser Ser Tyr His Val Lys Thr Ala Phe Phe His Val Cys Thr Gln 
        435                 440                 445             


Asn Pro Gln Asp Ser Gln Trp Asp Arg Lys Asp Leu Gly Leu Cys Phe 
    450                 455                 460                 


Asp Asn Cys Val Thr Tyr Phe Leu Gln Cys Leu Arg Thr Glu Lys Leu 
465                 470                 475                 480 


Glu Asn Tyr Phe Ile Pro Glu Phe Asn Leu Phe Ser Ser Asn Leu Ile 
                485                 490                 495     


Asp Lys Arg Ser Lys Glu Phe Leu Thr Lys Gln Ile Glu Tyr Glu Arg 
            500                 505                 510         


Asn Asn Glu Phe Pro Val Phe Asp Glu Phe 
        515                 520         


<210> 1255
<211> 1569
<212> DNA
<213> Homo sapiens

<400> 1255
atgcaaccat ggcatggtaa ggcaatgcaa cgtgcatctg aggctggagc taccgcgccc       60

aaagcttcag cacggaacgc gcgcggtgct ccgatggatc cgacggagag ccctgctgca      120

ccggaagccg ctctgccaaa agcgggtaaa ttcgggccgg cgcggaaatc aggctcacgc      180

cagaaaaaga gtgctccgga tacacaggaa cgtccgcctg taagagctac cggcgcgcgc      240

gctaaaaaag cccctcagcg tgcgcaggat acccaaccat cggatgcaac gagcgcaccg      300

ggggcggagg gccttgagcc tcctgctgcg cgtgagccgg ccctctctcg cgcagggagt      360

tgccgccaac gaggcgcacg ctgctcgacg aaaccgcggc cccctccggg tccgtgggat      420

gttccatcgc caggcctgcc ggtttctgcg cctattctcg ttcgccgcga cgcggctcct      480

ggcgcttcga aactgagagc tgtcttagag aaactgaaac tctcgcggga tgatatatct      540

actgcggcag ggatggtcaa aggtgttgtg gatcatctcc tgttacgtct taagtgcgat      600

tcggccttcc gaggtgttgg ccttttaaac actgggtcat actatgagca cgttaagatc      660

agcgcgccga acgagttcga cgttatgttt aagcttgaag tccctcgcat acagctggaa      720

gaatactcca atacacgagc atattatttt gttaaattca aacgaaaccc caaagagaac      780

cctctttcac agtttctgga gggagaaatt ctgtctgcga gtaagatgct ctcgaagttc      840

cgaaaaatca ttaaagagga aatcaacgac atcaaagaca ctgatgttat catgaagagg      900

aaacgtgggg gctcaccggc ggtaacactg ctgatttcgg aaaagatctc agttgatatt      960

actttggcgc tcgaatcaaa atcatcgtgg ccggcgagta cacaggaagg gctccgtatt     1020

cagaattggc tgtctgcgaa agtccgcaaa caactgcgtt tgaaaccatt ttatttagtg     1080

ccaaaacacg cgaaagaagg caacggtttc caggaggaga cgtggcgact gtcatttagc     1140

cacatagaaa aggaaatatt aaataatcac gggaaaagta agacgtgctg cgagaataaa     1200

gaagagaagt gctgcaggaa agattgtctg aaactgatga aatacctgtt ggagcagctg     1260

aaagagaggt ttaaagataa gaagcatctg gacaaatttt cttcatatca cgttaaaacc     1320

gcattcttcc acgtatgcac acagaatccg caggactcac agtgggatcg gaaagatctg     1380

ggcctgtgct ttgacaactg cgtcacatat ttcttgcagt gcttgaggac tgaaaaattg     1440

gaaaactact tcattcccga gttcaattta ttcagtagta acctgatcga caagcgtagc     1500

aaagaattcc tgacgaagca gatcgaatac gaaagaaata acgaattccc ggtgtttgat     1560

gaattttaa                                                             1569


<210> 1256
<211> 1594
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1256
acctattggt ataaggaggt aaataatgca accatggcat ggtaaggcaa tgcaacgtgc       60

atctgaggct ggagctaccg cgcccaaagc ttcagcacgg aacgcgcgcg gtgctccgat      120

ggatccgacg gagagccctg ctgcaccgga agccgctctg ccaaaagcgg gtaaattcgg      180

gccggcgcgg aaatcaggct cacgccagaa aaagagtgct ccggatacac aggaacgtcc      240

gcctgtaaga gctaccggcg cgcgcgctaa aaaagcccct cagcgtgcgc aggataccca      300

accatcggat gcaacgagcg caccgggggc ggagggcctt gagcctcctg ctgcgcgtga      360

gccggccctc tctcgcgcag ggagttgccg ccaacgaggc gcacgctgct cgacgaaacc      420

gcggccccct ccgggtccgt gggatgttcc atcgccaggc ctgccggttt ctgcgcctat      480

tctcgttcgc cgcgacgcgg ctcctggcgc ttcgaaactg agagctgtct tagagaaact      540

gaaactctcg cgggatgata tatctactgc ggcagggatg gtcaaaggtg ttgtggatca      600

tctcctgtta cgtcttaagt gcgattcggc cttccgaggt gttggccttt taaacactgg      660

gtcatactat gagcacgtta agatcagcgc gccgaacgag ttcgacgtta tgtttaagct      720

tgaagtccct cgcatacagc tggaagaata ctccaataca cgagcatatt attttgttaa      780

attcaaacga aaccccaaag agaaccctct ttcacagttt ctggagggag aaattctgtc      840

tgcgagtaag atgctctcga agttccgaaa aatcattaaa gaggaaatca acgacatcaa      900

agacactgat gttatcatga agaggaaacg tgggggctca ccggcggtaa cactgctgat      960

ttcggaaaag atctcagttg atattacttt ggcgctcgaa tcaaaatcat cgtggccggc     1020

gagtacacag gaagggctcc gtattcagaa ttggctgtct gcgaaagtcc gcaaacaact     1080

gcgtttgaaa ccattttatt tagtgccaaa acacgcgaaa gaaggcaacg gtttccagga     1140

ggagacgtgg cgactgtcat ttagccacat agaaaaggaa atattaaata atcacgggaa     1200

aagtaagacg tgctgcgaga ataaagaaga gaagtgctgc aggaaagatt gtctgaaact     1260

gatgaaatac ctgttggagc agctgaaaga gaggtttaaa gataagaagc atctggacaa     1320

attttcttca tatcacgtta aaaccgcatt cttccacgta tgcacacaga atccgcagga     1380

ctcacagtgg gatcggaaag atctgggcct gtgctttgac aactgcgtca catatttctt     1440

gcagtgcttg aggactgaaa aattggaaaa ctacttcatt cccgagttca atttattcag     1500

tagtaacctg atcgacaagc gtagcaaaga attcctgacg aagcagatcg aatacgaaag     1560

aaataacgaa ttcccggtgt ttgatgaatt ttaa                                 1594


<210> 1257
<211> 273
<212> PRT
<213> Listeria monocytogenes

<400> 1257
Met Asp Phe Ser Asn Met Ser Ile Leu His Tyr Leu Ala Asn Ile Val 
1               5                   10                  15      


Asp Ile Leu Val Val Trp Phe Val Ile Tyr Lys Val Ile Met Leu Ile 
            20                  25                  30          


Arg Gly Thr Lys Ala Val Gln Leu Leu Lys Gly Ile Phe Ile Ile Ile 
        35                  40                  45              


Ala Val Lys Leu Leu Ser Gly Phe Phe Gly Leu Gln Thr Val Glu Trp 
    50                  55                  60                  


Ile Thr Asp Gln Met Leu Thr Trp Gly Phe Leu Ala Ile Ile Ile Ile 
65                  70                  75                  80  


Phe Gln Pro Glu Leu Arg Arg Ala Leu Glu Thr Leu Gly Arg Gly Asn 
                85                  90                  95      


Ile Phe Thr Arg Tyr Gly Ser Arg Ile Glu Arg Glu Gln His His Leu 
            100                 105                 110         


Ile Glu Ser Ile Glu Lys Ser Thr Gln Tyr Met Ala Lys Arg Arg Ile 
        115                 120                 125             


Gly Ala Leu Ile Ser Val Ala Arg Asp Thr Gly Met Asp Asp Tyr Ile 
    130                 135                 140                 


Glu Thr Gly Ile Pro Leu Asn Ala Lys Ile Ser Ser Gln Leu Leu Ile 
145                 150                 155                 160 


Asn Ile Phe Ile Pro Asn Thr Pro Leu His Asp Gly Ala Val Ile Ile 
                165                 170                 175     


Lys Gly Asn Glu Ile Ala Ser Ala Ala Ser Tyr Leu Pro Leu Ser Asp 
            180                 185                 190         


Ser Pro Phe Leu Ser Lys Glu Leu Gly Thr Arg His Arg Ala Ala Leu 
        195                 200                 205             


Gly Ile Ser Glu Val Thr Asp Ser Ile Thr Ile Val Val Ser Glu Glu 
    210                 215                 220                 


Thr Gly Gly Ile Ser Leu Thr Lys Gly Gly Glu Leu Phe Arg Asp Val 
225                 230                 235                 240 


Ser Glu Glu Glu Leu His Lys Ile Leu Leu Lys Glu Leu Val Thr Val 
                245                 250                 255     


Thr Ala Lys Lys Pro Ser Ile Phe Ser Lys Trp Lys Gly Gly Lys Ser 
            260                 265                 270         


Glu 
    


<210> 1258
<211> 822
<212> DNA
<213> Listeria monocytogenes

<400> 1258
atggactttt ccaacatgag tatccttcac tatttagcga atattgtaga cattttggtg       60

gtttggttcg taatttacaa ggttatcatg cttatccgcg gcacgaaagc cgtccagctg      120

ttgaagggga ttttcattat tattgccgtc aagttactta gcggcttctt cggattgcag      180

acagtggaat ggattactga tcaaatgctg acttggggtt tcttagccat tatcattatc      240

tttcaaccgg aattgcgtcg tgccctggag actttggggc gtggcaatat ctttacccgc      300

tatggatcac gcattgagcg tgaacaacac caccttattg agtctattga aaagtccacg      360

caatacatgg cgaagcgtcg cattggagct ttgatctctg tggctcgtga tacaggcatg      420

gacgactaca tcgagactgg cattccgctt aatgcgaaaa tctcatcgca attattgatt      480

aatatcttca tccccaatac ccctcttcac gatggcgcag tgatcattaa aggtaacgag      540

atcgcgagcg ctgccagtta tctgccattg tccgactcgc cgtttctttc taaggagctg      600

ggaactcgcc atcgtgccgc attagggatt tccgaggtga cagattcaat cacaatcgtt      660

gtcagcgagg aaacaggtgg gatttccctt acgaagggag gcgaactgtt ccgtgatgta      720

tccgaagaag aattgcataa gattttgctt aaagagctgg tgactgtcac agctaaaaaa      780

ccaagcattt tctccaaatg gaaaggaggt aagtccgagt ga                         822


<210> 1259
<211> 3787
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1259
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttt      900

aagacccact ttcacattta agttgttttt ctaatccgca tatgatcaat tcaaggccga      960

ataagaaggc tggctctgca ccttggtgat caaataattc gatagcttgt cgtaataatg     1020

gcggcatact atcagtagta ggtgtttccc tttcttcttt agcgacttga tgctcttgat     1080

cttccaatac gcaacctaaa gtaaaatgcc ccacagcgct gagtgcatat aatgcattct     1140

ctagtgaaaa accttgttgg cataaaaagg ctaattgatt ttcgagagtt tcatactgtt     1200

tttctgtagg ccgtgtacct aaatgtactt ttgctccatc gcgatgactt agtaaagcac     1260

atctaaaact tttagcgtta ttacgtaaaa aatcttgcca gctttcccct tctaaagggc     1320

aaaagtgagt atggtgccta tctaacatct caatggctaa ggcgtcgagc aaagcccgct     1380

tattttttac atgccaatac aatgtaggct gctctacacc tagcttctgg gcgagtttac     1440

gggttgttaa accttcgatt ccgacctcat taagcagctc taatgcgctg ttaatcactt     1500

tacttttatc taatctagac atcattaatt cctaattttt gttgacactc tatcattgat     1560

agagttattt taccactccc tatcagtgat agagaaaagt gaacccgcat cccacgctaa     1620

ctaatataag gggggcaaga atggactttt ccaacatgag tatccttcac tatttagcga     1680

atattgtaga cattttggtg gtttggttcg taatttacaa ggttatcatg cttatccgcg     1740

gcacgaaagc cgtccagctg ttgaagggga ttttcattat tattgccgtc aagttactta     1800

gcggcttctt cggattgcag acagtggaat ggattactga tcaaatgctg acttggggtt     1860

tcttagccat tatcattatc tttcaaccgg aattgcgtcg tgccctggag actttggggc     1920

gtggcaatat ctttacccgc tatggatcac gcattgagcg tgaacaacac caccttattg     1980

agtctattga aaagtccacg caatacatgg cgaagcgtcg cattggagct ttgatctctg     2040

tggctcgtga tacaggcatg gacgactaca tcgagactgg cattccgctt aatgcgaaaa     2100

tctcatcgca attattgatt aatatcttca tccccaatac ccctcttcac gatggcgcag     2160

tgatcattaa aggtaacgag atcgcgagcg ctgccagtta tctgccattg tccgactcgc     2220

cgtttctttc taaggagctg ggaactcgcc atcgtgccgc attagggatt tccgaggtga     2280

cagattcaat cacaatcgtt gtcagcgagg aaacaggtgg gatttccctt acgaagggag     2340

gcgaactgtt ccgtgatgta tccgaagaag aattgcataa gattttgctt aaagagctgg     2400

tgactgtcac agctaaaaaa ccaagcattt tctccaaatg gaaaggaggt aagtccgagt     2460

gaggaggaac gattggtaaa cccggtgaac gcatgagaaa gcccccggaa gatcaccttc     2520

cgggggcttt tttattgcgc ggaccaaaac gaaaaaagac gctcgaaagc gtctcttttc     2580

tggaatttgg taccgaggcg taatgctctg ccagtgttac aaccaattaa ccaattctga     2640

ttagaaaaac tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag gattatcaat     2700

accatatttt tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga ggcagttcca     2760

taggatggca agatcctggt atcggtctgc gattccgact cgtccaacat caatacaacc     2820

tattaatttc ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat gagtgacgac     2880

tgaatccggt gagaatggca aaagcttatg catttctttc cagacttgtt caacaggcca     2940

gccattacgc tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca ttcgtgattg     3000

cgcctgagcg agacgaaata cgcgatcgct gttaaaagga caattacaaa caggaatcga     3060

atgcaaccgg cgcaggaaca ctgccagcgc atcaacaata ttttcacctg aatcaggata     3120

ttcttctaat acctggaatg ctgttttccc ggggatcgca gtggtgagta accatgcatc     3180

atcaggagta cggataaaat gcttgatggt cggaagaggc ataaattccg tcagccagtt     3240

tagtctgacc atctcatctg taacatcatt ggcaacgcta cctttgccat gtttcagaaa     3300

caactctggc gcatcgggct tcccatacaa tcgatagatt gtcgcacctg attgcccgac     3360

attatcgcga gcccatttat acccatataa atcagcatcc atgttggaat ttaatcgcgg     3420

cctcgagcaa gacgtttccc gttgaatatg gctcataaca ccccttgtat tactgtttat     3480

gtaagcagac agttttattg ttcatgatga tatattttta tcttgtgcaa tgtaacatca     3540

gagattttga gacacaacgt ggctttgttg aataaatcga acttttgctg agttgaagga     3600

tcagatcacg catcttcccg acaacgcaga ccgttccgtg gcaaagcaaa agttcaaaat     3660

caccaactgg tccacctaca acaaagctct catcaaccgt ggctccctca ctttctggct     3720

ggatgatggg gcgattcagg cctggtatga gtcagcaaca ccttcttcac gaggcagacc     3780

tcagcgc                                                               3787


<210> 1260
<211> 403
<212> PRT
<213> Kingella denitrificans

<400> 1260
Met Ser Asp Tyr Thr Asn Asn Leu His Arg Val Phe Val Asp Gln Lys 
1               5                   10                  15      


Ile Gly Phe Lys Lys Lys Ile Thr Pro Thr Glu Gln Asp Leu Asn Phe 
            20                  25                  30          


Phe Asn Gln Val Lys Lys Asp Val Lys Ser His Leu Lys Thr Lys Ile 
        35                  40                  45              


Lys Glu Phe Leu Glu Gln Gln Gly Ile Ala Asn Ile Ala Pro Lys Phe 
    50                  55                  60                  


Arg Ile Gln Gly Ser Trp Ala Tyr Gly Thr Cys Asn Leu Pro Ala Lys 
65                  70                  75                  80  


Gln Asp Gln Glu Met Asp Phe Asp Tyr Gly Val Tyr Leu Pro Val Arg 
                85                  90                  95      


Ala Phe Glu Gly Phe Asn Pro Asp Ala Gly Ala Ser Glu Gln Ala Gln 
            100                 105                 110         


Asn Tyr Phe Glu Gln Val Glu Leu Met Val Glu Asp Leu Cys His Gln 
        115                 120                 125             


His Lys Trp Gln Leu Asp Thr Ser Ala Pro Ser Ser Cys Ile Arg Ile 
    130                 135                 140                 


Lys Ile Arg Ser Asn Ala His Met Asp Ile Pro Leu Tyr Ala Val Pro 
145                 150                 155                 160 


Asp Asp Met Phe Asp Ser Leu Glu Glu Arg Asn Glu Leu Gln Val Ser 
                165                 170                 175     


Leu Gly Thr Thr Thr Ala Ile Asp Lys Ser Leu Asn Tyr Ser Glu Trp 
            180                 185                 190         


Ala Leu Glu Asp Phe Asn Ile Arg Ser Phe Ala Glu Glu Ser Leu Met 
        195                 200                 205             


Asp Lys Asn Ile Arg Met Ile His Met Ala Arg Arg Asp Gly Thr Trp 
    210                 215                 220                 


Gln Lys Ser Asp Cys Glu Leu Ile Arg Lys Trp Phe Ala Asp Lys Leu 
225                 230                 235                 240 


Lys Ser Leu Glu Asn Asn Gly Gln Gln Leu Arg Ala Ile Cys Arg Tyr 
                245                 250                 255     


Leu Lys Ala Trp Arg Asp Trp Gln Phe Ala Asp Lys Ser Phe Gln Pro 
            260                 265                 270         


Ser Ser Ile Leu Leu Met Ile Ile Ala Cys Lys Tyr Tyr Gln Tyr His 
        275                 280                 285             


Gln His Arg Asp Asp Leu Ala Leu Leu Ser Val Leu Glu Lys Leu Pro 
    290                 295                 300                 


Asn Ala Leu Asn Asp Asn Val Tyr Glu Asn Ile Glu Glu His Glu Ser 
305                 310                 315                 320 


Glu Asp Phe Asn Arg Met Glu Glu Tyr Glu Arg Val Glu Ala Ser Gln 
                325                 330                 335     


Tyr Ala Asp Ala Leu Tyr Gln Ser Phe Met Ala Ser Leu Asn Asn Leu 
            340                 345                 350         


Asp Lys Thr Lys Val Leu Asn Phe Ile Thr Asn Glu Trp Gly Asp Arg 
        355                 360                 365             


Ile Pro Gln Asp Glu Asn Leu Ile Glu Thr Ser Pro Gln Ser Ile Phe 
    370                 375                 380                 


Asp Thr Pro Pro Leu Ala Gln Ser Asn Ile Thr Gln Gln Val Pro Leu 
385                 390                 395                 400 


Arg Gln Gly 
            


<210> 1261
<211> 403
<212> PRT
<213> Neisseria bacilliformis

<400> 1261
Met Ser His Tyr Thr Asn Asn Leu His Arg Ile Phe Val Asp Arg Glu 
1               5                   10                  15      


Ile Gly Phe Lys Lys Glu Ile Thr Pro Thr Glu Leu Asp Leu Asp Phe 
            20                  25                  30          


Phe Asn Asn Val Lys Lys Val Val Lys Ser His Leu Lys Thr Lys Ile 
        35                  40                  45              


Lys Glu Phe Leu Glu Gln Gln Gly Leu Ala Ser Ile Thr Pro Lys Phe 
    50                  55                  60                  


Arg Ile Gln Gly Ser Trp Ala Tyr Gly Thr Cys Asn Leu Pro Ala Lys 
65                  70                  75                  80  


Gln Gly Gln Glu Met Asp Phe Asp Tyr Gly Val Tyr Leu Pro Val Arg 
                85                  90                  95      


Ala Phe Asp Gly Phe Asn Pro Asp Ala Gly Ala Ser Glu Gln Ala Lys 
            100                 105                 110         


Asn Tyr Phe Glu Gln Val Glu Leu Met Met Gly Asp Leu Cys Glu Gln 
        115                 120                 125             


His Asp Trp Leu Leu Asp Thr Ser Ala Pro Ser Ser Cys Ile Arg Ile 
    130                 135                 140                 


Lys Ile Arg Asn Asn Ala His Met Asp Ile Pro Leu Tyr Ala Val Pro 
145                 150                 155                 160 


Asp Asp Met Phe Asp Ser Leu Glu Glu Arg Asn Glu Leu Gln Val Ser 
                165                 170                 175     


Leu Gly Ser Ala Thr Ala Ile His Glu Ser Leu Asn Tyr Ser Lys Trp 
            180                 185                 190         


Val Phe Glu Asp Phe Asn Ile Arg Ser Phe Ala Glu Glu Ser Leu Met 
        195                 200                 205             


Asp Lys Asn Ile Arg Met Ile His Met Ala Arg Arg Asp Gly Thr Trp 
    210                 215                 220                 


Gln Glu Ser Asp Cys Glu Leu Ile Arg Lys Trp Phe Ala Asp Lys Leu 
225                 230                 235                 240 


Lys Ser Leu Glu Asn Asn Gly Gln Gln Leu Arg Ala Ile Cys Arg Tyr 
                245                 250                 255     


Leu Lys Ala Trp Arg Asp Trp Gln Phe Ala Asp Lys Ser Phe Gln Pro 
            260                 265                 270         


Ser Ser Ile Leu Leu Met Ile Ile Ala Cys Lys Tyr Tyr Gln Tyr Tyr 
        275                 280                 285             


Gln His Arg Asp Asp Leu Ala Leu Leu Ser Val Leu Glu Lys Leu Pro 
    290                 295                 300                 


Asn Ala Leu Ser Gly Asn Val Tyr Glu Asn Ile Glu Glu His Glu Ser 
305                 310                 315                 320 


Glu Asp Phe Asn Arg Met Lys Glu Gly Glu Arg Val Glu Ala Met Gln 
                325                 330                 335     


Tyr Ala Asp Ala Leu Tyr Gln Asn Phe Met Ala Ser Leu Asn Asn Phe 
            340                 345                 350         


Asp Lys Thr Lys Ala Leu Lys Phe Ile Thr Asn Glu Trp Gly Asn Arg 
        355                 360                 365             


Ile Pro Gln Asp Glu Asp Leu Ile Glu Thr Ser Arg Gln Ala Ile Phe 
    370                 375                 380                 


Asp Thr Pro Pro Leu Val Gln Pro Asn Ile Thr Pro Gln Ala Pro Leu 
385                 390                 395                 400 


Arg Gln Gly 
            


<210> 1262
<211> 468
<212> PRT
<213> Verminephrobacter eiseniae

<400> 1262
Met Gly Gln Ala Ser Lys Leu Phe Asn Gly Asn Thr Asp Gln Thr Leu 
1               5                   10                  15      


Ile Gly Arg Val Thr Pro Thr Thr Glu Gln Arg Glu Phe Leu Gln Gln 
            20                  25                  30          


Gln Trp Asn Asp Leu Ala Asp His Leu Lys Gln Ala Leu Ala Lys His 
        35                  40                  45              


Gly Tyr Thr Ile Ser Thr Trp Leu Gln Gly Ser Tyr Lys Tyr Ala Thr 
    50                  55                  60                  


Leu Ile Lys Pro Val His Leu Gly Glu Glu Tyr Asp Val Asp Val Gly 
65                  70                  75                  80  


Leu Tyr Phe Glu Trp Asn Asp Asp Gln Asp Ala Glu Pro Thr Pro Lys 
                85                  90                  95      


Gln Leu Arg Asp Trp Val Gln Ala Glu Leu Leu Glu Tyr Glu Lys Ala 
            100                 105                 110         


Cys Glu Glu Leu Lys Lys Val Glu Val Pro Pro Lys Glu Arg Cys Ser 
        115                 120                 125             


Arg Ala Ser Tyr Ile Gln Gln Phe His Ile Asp Thr Pro Val Tyr His 
    130                 135                 140                 


Leu Asn Thr Asp Ser Asp Val Arg Arg Leu Ala Cys Leu Ser Gly Lys 
145                 150                 155                 160 


Trp Glu His Ser Asp Pro Lys Lys Leu Tyr Lys Trp Phe Lys Glu Ala 
                165                 170                 175     


Val Ser Gly Asp Asp Arg Asp Gln Leu Arg Arg Leu Val Arg Tyr Leu 
            180                 185                 190         


Lys Ala Trp Ala Ala Val Ser Phe Asp Asp Ala Pro Gly Ser Arg Pro 
        195                 200                 205             


Ser Ser Ile Phe Leu Thr Val Ile Ala Thr Glu Ala Tyr Gln Asp Leu 
    210                 215                 220                 


Trp Ala Gln Arg Leu Leu Gly Leu Ala Asp Asp Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Val Ile Lys Lys Met His Asp Arg Leu Phe Asp Asp Arg Lys Val Glu 
                245                 250                 255     


Asn Pro Val Asp Lys Asn Glu Asp Leu Asn Arg Met Thr Ala Glu Ala 
            260                 265                 270         


Trp Asp Gly Phe Leu Pro Arg Leu Ala Ala Leu Gln Asp Ile Ala Glu 
        275                 280                 285             


Arg Ala Gly Asp Ala Lys Asp Glu Ala Ser Ala Ala Leu Ile Trp Ser 
    290                 295                 300                 


Glu Ala Phe Ser Phe Leu Met Pro Leu Pro Glu Thr Asp Gln Val Glu 
305                 310                 315                 320 


Ile Val Asp Glu Gly Ser Gly Arg Ala Val Met Gln Leu Pro Glu Ile 
                325                 330                 335     


Glu Val Lys Val Cys Thr Gly Thr Pro Pro Arg Pro Val Ala Thr Tyr 
            340                 345                 350         


Arg Asn Glu Val Pro Gly Val Ala Lys Asp Cys Met Leu Ser Phe Ala 
        355                 360                 365             


Ile Val Asn Pro His Val Val Pro Glu Phe Ala Thr Val Glu Trp Thr 
    370                 375                 380                 


Val Arg Asn Glu Gly Gln Glu Ala Asp Gln Arg Ser Asp Leu Gly His 
385                 390                 395                 400 


Arg Arg Val Gly Met Arg Leu Leu Ser Val Glu Glu His Thr Ala Tyr 
                405                 410                 415     


Val Gly Arg His Phe Met Asp Cys Val Val Arg Leu Asn Gly Gln Val 
            420                 425                 430         


Tyr Ala Val Arg Arg Val Pro Val Thr Ile Arg Asp Val Gln His Val 
        435                 440                 445             


Ala Arg Asn Pro Pro Arg Pro Pro Tyr Thr Lys Leu Arg Ser Leu Phe 
    450                 455                 460                 


Arg Arg Arg Arg 
465             


<210> 1263
<211> 1213
<212> DNA
<213> Kingella denitrificans

<400> 1263
atgtcagact acactaataa cttgcatcgc gtctttgttg accaaaaaat tgggttcaag       60

aagaaaatca ctcctaccga gcaagatctg aactttttca atcaggtcaa gaaagatgta      120

aagtcccacc ttaagaccaa aatcaaggaa tttcttgagc aacagggaat cgcgaacatt      180

gctccgaagt tccgtattca gggatcgtgg gcttacggga catgtaattt gcccgcaaaa      240

caggaccagg agatggattt cgattacggg gtatatctgc cagtacgtgc cttcgagggg      300

ttcaacccag acgcaggcgc gtctgagcag gctcaaaact attttgaaca ggtcgagttg      360

atggttgaag atctgtgcca ccagcataaa tggcagctgg acacgtctgc cccttcgtcc      420

tgtatccgca ttaaaattcg cagcaacgct catatggaca ttcctttata tgccgtcccg      480

gatgatatgt tcgattctct tgaagagcgc aatgagttac aagtatcact gggcacgaca      540

acggctatcg ataagtcact gaattacagc gagtgggcac tggaggactt taatatccgc      600

tcattcgccg aagaaagttt aatggataag aacattcgca tgatccacat ggcgcgtcgt      660

gacgggactt ggcaaaagtc ggattgcgag ctgattcgca aatggttcgc agacaaactg      720

aagagcttgg agaataacgg gcaacagctg cgtgcgatct gtcgttacct taaggcgtgg      780

cgcgattggc aattcgctga caagtcgttt caaccatcct ctatcttgtt aatgattatc      840

gcgtgcaaat attatcaata ccatcaacac cgtgacgatt tagcactttt atccgtgctt      900

gaaaagttgc caaacgcttt aaacgataat gtttatgaga atattgaaga acacgaatcc      960

gaagacttta accgtatgga agagtatgaa cgcgttgagg cgtcgcagta tgccgacgcg     1020

ttgtaccaga gtttcatggc ctccttaaac aatttggaca aaactaaggt tttaaatttt     1080

atcactaatg agtgggggga tcgcattcca caagacgaga acttaatcga gacatctcct     1140

caatcaattt tcgatactcc ccccttggca caaagcaata tcacgcaaca agtgcccttg     1200

cgccagggtt aas                                                        1213


<210> 1264
<211> 1212
<212> DNA
<213> Neisseria bacilliformis

<400> 1264
atgtctcact acaccaataa tcttcatcgt atcttcgtag atcgtgaaat tggttttaag       60

aaagagatta ctccgacaga gctggatctt gacttcttca acaacgtcaa aaaagtagtt      120

aagagccacc ttaaaaccaa aatcaaggag tttcttgaac agcaagggct ggcgagtatt      180

actcctaagt ttcgtatcca gggaagctgg gcgtacggaa catgtaacct tccagccaag      240

cagggtcagg aaatggactt cgattatggc gtttatcttc ctgtccgcgc ctttgatgga      300

tttaatcctg atgcaggtgc ctcagaacaa gctaagaatt acttcgaaca ggtggagctt      360

atgatgggtg acctgtgcga gcagcatgac tggttgttgg acacatccgc gccctcttcg      420

tgtattcgca tcaaaatccg caataatgcc catatggaca ttcctttata tgcagttcca      480

gacgatatgt tcgatagcct ggaggaacgt aacgaattac aggtttcctt gggatcagcg      540

acagctattc acgaatcgct gaattattca aagtgggttt ttgaggattt taacatccgc      600

tcttttgctg aggaatccct gatggacaaa aatatccgca tgatccacat ggcccgccgt      660

gacggaactt ggcaggagtc tgattgtgag ttgattcgca aatggtttgc tgacaagttg      720

aaatcccttg agaataatgg tcagcagctt cgtgcaattt gtcgctatct taaagcctgg      780

cgcgattggc aattcgcaga taagtctttt caaccctcca gtatcctgtt gatgatcatt      840

gcgtgtaagt actatcagta ctaccaacat cgtgacgacc tggcactgct gtccgtgctg      900

gagaaattgc ccaacgcttt gtctgggaac gtctatgaga atattgagga acatgagtct      960

gaggacttta accgtatgaa agagggcgag cgtgtagaag caatgcaata tgcggacgcg     1020

ttataccaaa acttcatggc gtctcttaac aattttgata aaacgaaggc gctgaaattc     1080

atcactaatg aatggggaaa tcgtatccca caagatgaag acttaatcga aacgtctcgt     1140

caggcaattt ttgacacacc acccttagtt caacccaaca tcactccaca ggccccactt     1200

cgccaggggt aa                                                         1212


<210> 1265
<211> 1407
<212> DNA
<213> Verminephrobacter eiseniae

<400> 1265
atgggacagg cgtctaagtt atttaatggt aatacagatc aaactttaat tggccgcgtg       60

acgcccacta ccgaacaacg cgagttttta caacagcagt ggaatgatct ggcagatcac      120

ttgaagcaag ccctggcaaa acacggttat acaatttcga catggcttca gggttcttac      180

aaatacgcga ctcttattaa gcctgtgcat ctgggtgaag agtatgacgt agatgtaggg      240

ttgtactttg agtggaacga tgaccaggat gcggagccca cgcctaagca gctgcgtgat      300

tgggtgcaag cggagttgtt agagtatgag aaggcttgtg aggaacttaa gaaagttgag      360

gtgccgccga aagaacgctg ttctcgcgca tcatacatcc aacaatttca cattgacaca      420

ccagtttatc atctgaacac ggactccgac gtgcgccgtc ttgcttgcct tagtggaaag      480

tgggagcatt ctgatccgaa aaagttatac aagtggttta aagaagcagt atccggggat      540

gatcgtgacc aattacgccg tcttgtacgt tacttaaagg cctgggctgc ggtttccttt      600

gatgacgcac cgggatcccg cccatctagc atttttctta cggttattgc tactgaagcc      660

tatcaggact tgtgggcaca acgtttactg ggattagctg acgatgacgc tttgctggca      720

gtgattaaaa agatgcacga ccgccttttc gatgaccgca aggtcgagaa tcccgtagat      780

aaaaacgaag acttaaatcg catgacggct gaagcgtggg acggttttct gccccgcttg      840

gcggcacttc aagacattgc ggaacgcgcc ggagatgcta aggatgaggc gtcagccgca      900

ttgatctgga gcgaagcgtt tagttttttg atgcccttgc cggaaactga tcaggtagaa      960

atcgtagacg aaggctcagg ccgtgccgtc atgcaattgc cagaaattga ggtaaaggtc     1020

tgcactggca cgccaccccg cccagtcgca acgtatcgta atgaggtccc aggagtagca     1080

aaagactgca tgttgtcctt tgcgattgtc aatccacatg tggttccgga gtttgccacg     1140

gtggagtgga ctgtgcgtaa tgagggacag gaggcggacc agcgtagtga tttagggcac     1200

cgtcgcgtcg ggatgcgttt gttgagtgta gaggaacata cggcatatgt cggtcgtcac     1260

tttatggatt gtgtagtccg tctgaacggg caagtttacg ctgtccgtcg cgtacccgtt     1320

accattcgcg acgttcagca cgtcgcccgc aatcccccac gtccacctta cacaaaactg     1380

cgcagtttat tccgccgccg tcgctaa                                         1407


<210> 1266
<211> 4045
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1266
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagtac      900

atgtctaacg tttgaatttt gcgtaacgtt cgcgagcaat ctctaaagtg ctattacgta      960

cacgctcaaa acgttcctta tccttctgcc ataacgaacg caccgcaaga ccacgcacgc     1020

tgttaaaaat caaccacaaa atgtcctcgg catcgtcacg ggataatcca cgcgacacca     1080

gaacgcccaa ccacatatcc tcgaccacaa aacggttgcg ctctaccgtg cgttggatac     1140

cctcacgcag agctggatca cgatcagcgg ccacaatcag atcaaggcta attgaaaagt     1200

cgtcatccaa gaaaaactca gcggcatcat caagcatttg ctgaatcaca tcatcttccg     1260

gttttaactt agccaggcga gcacggctgc gctcggtgat ctgctcatac agccactcaa     1320

acgtagcaag caacagttct aatttggtgg gaaaatggtg tgactgggcg ccacgagaca     1380

cccccgcggc gcccggtaca tccgcaatac gaaaacccgc gtatcccttc tcgcgtaata     1440

caccaagcgc cgccgcgatc agtttacctt gtgtttccat cgcacgttcg gcttgagtac     1500

ggcgcttggg cgacatgatt accatcttgc gaaacgatcc tcatcctgtc tcttgatcag     1560

atcttgatcc cctgcgccat cagatccttg gcggcaagaa agccatccag tttactttgc     1620

agggcttccc aaccttacca gagggcgccc cagctggcaa ttccggacgc gttgcgccta     1680

gggggaatgg tccatgcctg cagtaacacc gtgcgtgttg actattttac ctctggcggt     1740

gataatggtt gcaacaaaca gacaatctgg tctgtttgta ttatgttaac cagcacactg     1800

gcggccgctt actagaaata attttggccg catcccacgc taactaatat aaaggaggtt     1860

ttaaatggac ttttccaaca tgagtatcct tcactattta gcgaatattg tagacatttt     1920

ggtggtttgg ttcgtaattt acaaggttat catgcttatt cgcggcacga aagccgtcca     1980

gctgttgaag gggattttca ttattattgc cgtcaagtta cttagcggct tcttcggatt     2040

gcagacagtg gaatggatta ctgatcaaat gctgacttgg ggtttcttag ccattatcat     2100

tatctttcaa ccggaattgc gtcgtgccct ggagactttg gggcgtggca atatctttac     2160

ccgctatgga tcacgcattg agcgtgaaca acaccacctt attgagtcta ttgaaaagtc     2220

cacgcaatac atggcgaagc gtcgcattgg agctttgatc tctgtggctc gtgatacagg     2280

catggacgac tacatcgaga ctggcattcc gcttaatgcg aaaatctcat cgcaattatt     2340

gattaatatc ttcatcccca atacccctct tcacgatggc gccgtgatca ttaaaggtaa     2400

cgagatcgcg agcgctgcca gttatctgcc attgtccgac tcgccgtttc tttctaagga     2460

gctgggaact cgccatcgtg ccgcattagg gatttccgag gtgacagatt caatcacaat     2520

cgttgtcagc gaggaaacag gtgggatttc ccttacgaag ggaggcgaac tgttccgtga     2580

tgtatccgaa gaagaattgc ataagatttt gcttaaagag ctggtgactg tcacagctaa     2640

aaaaccaagc attttctcca aatggaaagg aggtaagtcc gagtgatgag catgctaatc     2700

agccgtggaa ttcggtctca ggaggaacga ttggtaaacc cggtgaacgc atgagaaagc     2760

ccccggaaga tcaccttccg ggggcttttt tattgcgcgg accaaaacga aaaaagacgc     2820

tcgaaagcgt ctcttttctg gaatttggta ccgaggcgta atgctctgcc agtgttacaa     2880

ccaattaacc aattctgatt agaaaaactc atcgagcatc aaatgaaact gcaatttatt     2940

catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa     3000

ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg     3060

tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa     3120

atcaccatga gtgacgactg aatccggtga gaatggcaaa agcttatgca tttctttcca     3180

gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc     3240

gttattcatt cgtgattgcg cctgagcgag acgaaatacg cgatcgctgt taaaaggaca     3300

attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt     3360

ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttcccgg ggatcgcagt     3420

ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat     3480

aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc     3540

tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt     3600

cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat     3660

gttggaattt aatcgcggcc tcgagcaaga cgtttcccgt tgaatatggc tcataacacc     3720

ccttgtatta ctgtttatgt aagcagacag ttttattgtt catgatgata tatttttatc     3780

ttgtgcaatg taacatcaga gattttgaga cacaacgtgg ctttgttgaa taaatcgaac     3840

ttttgctgag ttgaaggatc agatcacgca tcttcccgac aacgcagacc gttccgtggc     3900

aaagcaaaag ttcaaaatca ccaactggtc cacctacaac aaagctctca tcaaccgtgg     3960

ctccctcact ttctggctgg atgatggggc gattcaggcc tggtatgagt cagcaacacc     4020

ttcttcacga ggcagacctc agcgc                                           4045


<210> 1267
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1267
cttgcgaaac gatcctcatc ctgtctcttg atcagatctt gatcccctgc gccatcagat       60

ccttggcggc aagaaagcca tccagtttac tttgcagggc ttcccaacct taccagaggg      120

cgccccagct ggcaattccg g                                                141


<210> 1268
<211> 621
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1268
ctaacgtttg aattttgcgt aacgttcgcg agcaatctct aaagtgctat tacgtacacg       60

ctcaaaacgt tccttatcct tctgccataa cgaacgcacc gcaagaccac gcacgctgtt      120

aaaaatcaac cacaaaatgt cctcggcatc gtcacgggat aatccacgcg acaccagaac      180

gcccaaccac atatcctcga ccacaaaacg gttgcgctct accgtgcgtt ggataccctc      240

acgcagagct ggatcacgat cagcggccac aatcagatca aggctaattg aaaagtcgtc      300

atccaagaaa aactcagcgg catcatcaag catttgctga atcacatcat cttccggttt      360

taacttagcc aggcgagcac ggctgcgctc ggtgatctgc tcatacagcc actcaaacgt      420

agcaagcaac agttctaatt tggtgggaaa atggtgtgac tgggcgccac gagacacccc      480

cgcggcgccc ggtacatccg caatacgaaa acccgcgtat cccttctcgc gtaatacacc      540

aagcgccgcc gcgatcagtt taccttgtgt ttccatcgca cgttcggctt gagtacggcg      600

cttgggcgac atgattacca t                                                621


<210> 1269
<211> 206
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1269
Met Val Ile Met Ser Pro Lys Arg Arg Thr Gln Ala Glu Arg Ala Met 
1               5                   10                  15      


Glu Thr Gln Gly Lys Leu Ile Ala Ala Ala Leu Gly Val Leu Arg Glu 
            20                  25                  30          


Lys Gly Tyr Ala Gly Phe Arg Ile Ala Asp Val Pro Gly Ala Ala Gly 
        35                  40                  45              


Val Ser Arg Gly Ala Gln Ser His His Phe Pro Thr Lys Leu Glu Leu 
    50                  55                  60                  


Leu Leu Ala Thr Phe Glu Trp Leu Tyr Glu Gln Ile Thr Glu Arg Ser 
65                  70                  75                  80  


Arg Ala Arg Leu Ala Lys Leu Lys Pro Glu Asp Asp Val Ile Gln Gln 
                85                  90                  95      


Met Leu Asp Asp Ala Ala Glu Phe Phe Leu Asp Asp Asp Phe Ser Ile 
            100                 105                 110         


Ser Leu Asp Leu Ile Val Ala Ala Asp Arg Asp Pro Ala Leu Arg Glu 
        115                 120                 125             


Gly Ile Gln Arg Thr Val Glu Arg Asn Arg Phe Val Val Glu Asp Met 
    130                 135                 140                 


Trp Leu Gly Val Leu Val Ser Arg Gly Leu Ser Arg Asp Asp Ala Glu 
145                 150                 155                 160 


Asp Ile Leu Trp Leu Ile Phe Asn Ser Val Arg Gly Leu Ala Val Arg 
                165                 170                 175     


Ser Leu Trp Gln Lys Asp Lys Glu Arg Phe Glu Arg Val Arg Asn Ser 
            180                 185                 190         


Thr Leu Glu Ile Ala Arg Glu Arg Tyr Ala Lys Phe Lys Arg 
        195                 200                 205     


<210> 1270
<211> 123
<212> DNA
<213> Escherichia coli

<400> 1270
taacaccgtg cgtgttgact attttacctc tggcggtgat aatggttgca acaaacagac       60

aatctggtct gtttgtatta tgttaaccag cacactggcg gccgcttact agaaataatt      120

ttg                                                                    123


<210> 1271
<211> 161
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1271
taacaccgtg cgtgttgact attttacctc tggcggtgat aatggttgca acaaacagac       60

aatctggtct gtttgtatta tgttaaccag cacactggcg gccgcttact agaaataatt      120

ttggccgcat cccacgctaa ctaatataaa ggaggtttta a                          161


<210> 1272
<211> 983
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1272
taacaccgtg cgtgttgact attttacctc tggcggtgat aatggttgca acaaacagac       60

aatctggtct gtttgtatta tgttaaccag cacactggcg gccgcttact agaaataatt      120

ttggccgcat cccacgctaa ctaatataaa ggaggtttta aatggacttt tccaacatga      180

gtatccttca ctatttagcg aatattgtag acattttggt ggtttggttc gtaatttaca      240

aggttatcat gcttattcgc ggcacgaaag ccgtccagct gttgaagggg attttcatta      300

ttattgccgt caagttactt agcggcttct tcggattgca gacagtggaa tggattactg      360

atcaaatgct gacttggggt ttcttagcca ttatcattat ctttcaaccg gaattgcgtc      420

gtgccctgga gactttgggg cgtggcaata tctttacccg ctatggatca cgcattgagc      480

gtgaacaaca ccaccttatt gagtctattg aaaagtccac gcaatacatg gcgaagcgtc      540

gcattggagc tttgatctct gtggctcgtg atacaggcat ggacgactac atcgagactg      600

gcattccgct taatgcgaaa atctcatcgc aattattgat taatatcttc atccccaata      660

cccctcttca cgatggcgcc gtgatcatta aaggtaacga gatcgcgagc gctgccagtt      720

atctgccatt gtccgactcg ccgtttcttt ctaaggagct gggaactcgc catcgtgccg      780

cattagggat ttccgaggtg acagattcaa tcacaatcgt tgtcagcgag gaaacaggtg      840

ggatttccct tacgaaggga ggcgaactgt tccgtgatgt atccgaagaa gaattgcata      900

agattttgct taaagagctg gtgactgtca cagctaaaaa accaagcatt ttctccaaat      960

ggaaaggagg taagtccgag tga                                              983


<210> 1273
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1273
tgtatttatc aatattgttt gctccgttat cgttattaac aagtcatcaa taaagccatc       60

acgagtacca tagaggatc                                                    79


<210> 1274
<211> 117
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1274
tgtatttatc aatattgttt gctccgttat cgttattaac aagtcatcaa taaagccatc       60

acgagtacca tagaggatcg ccgcatccca cgctaactaa tataaaggag gttttaa         117


<210> 1275
<211> 939
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1275
tgtatttatc aatattgttt gctccgttat cgttattaac aagtcatcaa taaagccatc       60

acgagtacca tagaggatcg ccgcatccca cgctaactaa tataaaggag gttttaaatg      120

gacttttcca acatgagtat ccttcactat ttagcgaata ttgtagacat tttggtggtt      180

tggttcgtaa tttacaaggt tatcatgctt attcgcggca cgaaagccgt ccagctgttg      240

aaggggattt tcattattat tgccgtcaag ttacttagcg gcttcttcgg attgcagaca      300

gtggaatgga ttactgatca aatgctgact tggggtttct tagccattat cattatcttt      360

caaccggaat tgcgtcgtgc cctggagact ttggggcgtg gcaatatctt tacccgctat      420

ggatcacgca ttgagcgtga acaacaccac cttattgagt ctattgaaaa gtccacgcaa      480

tacatggcga agcgtcgcat tggagctttg atctctgtgg ctcgtgatac aggcatggac      540

gactacatcg agactggcat tccgcttaat gcgaaaatct catcgcaatt attgattaat      600

atcttcatcc ccaatacccc tcttcacgat ggcgccgtga tcattaaagg taacgagatc      660

gcgagcgctg ccagttatct gccattgtcc gactcgccgt ttctttctaa ggagctggga      720

actcgccatc gtgccgcatt agggatttcc gaggtgacag attcaatcac aatcgttgtc      780

agcgaggaaa caggtgggat ttcccttacg aagggaggcg aactgttccg tgatgtatcc      840

gaagaagaat tgcataagat tttgcttaaa gagctggtga ctgtcacagc taaaaaacca      900

agcattttct ccaaatggaa aggaggtaag tccgagtga                             939


<210> 1276
<211> 1918
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1276
tcaatctgta aacaaatcga acatcagttg acgaagccag atattggcca aatccttatg       60

gtatttagcg tgccagaaca tattaatggc aatctcggga agcactaccg gatgaggcag      120

agcggacaag ccgaaaggtt cgacacagca atccgctaag cggatcggca ctgttgccag      180

caggtcagta cgttgaagaa tatggccaac ggctgcgaaa tggggcactt ccagacgaat      240

atcacgacgg atgcctacac gggtcatata cgtgtccact tcaccgtggc ctgtgcctgc      300

tgcaataaca cgtacatgtc cataactaca aaagcgttca agcgtcaatg gctcacgggt      360

aacggggtgg tccttgcggc acaaacaaac gtagtggttt tgcagtaaac ggcgttggaa      420

gaagcctgtt tgaaggttgg gcagaagccc caccgccaaa tcgacagttc cattttgcaa      480

cgcctgcatt aatgacatag acgaatcgcg gacagtagaa atgacgcagt tcggtgcttg      540

atgggcaagt acgtccatca ggcgaggcat gaaataaatc tccccaatat ccgtcattgc      600

cagggtgaaa gtacgctccg aagtaagggg gtcaaagctc tcatgatgtt gtaaagcgtt      660

acgaagggcg tgcatggcac tggtgacagg ctcggccaag tgtgcggcgt atggcgttgg      720

ttccatccct tggtgagtac ggacgaacaa cggatcttgt aacgatgtac gaaggcgttt      780

taatgcgtta gaaactgcgg gttgagtaag cccaagattt tctgcggtga tggagacgcg      840

acgatctacc agcagctgat taaagacaac taacaggtta aggtccagat cacgcaattc      900

catggggcct cgcttgggtt attgctggtg cccggccggg cgcaatattc atgttgatga      960

tttattatat atcgagtggt gtatttatca atattgtttg ctccgttatc gttattaaca     1020

agtcatcaat aaagccatca cgagtaccat agaggatcgc cgcatcccac gctaactaat     1080

ataaaggagg ttttaaatgg acttttccaa catgagtatc cttcactatt tagcgaatat     1140

tgtagacatt ttggtggttt ggttcgtaat ttacaaggtt atcatgctta ttcgcggcac     1200

gaaagccgtc cagctgttga aggggatttt cattattatt gccgtcaagt tacttagcgg     1260

cttcttcgga ttgcagacag tggaatggat tactgatcaa atgctgactt ggggtttctt     1320

agccattatc attatctttc aaccggaatt gcgtcgtgcc ctggagactt tggggcgtgg     1380

caatatcttt acccgctatg gatcacgcat tgagcgtgaa caacaccacc ttattgagtc     1440

tattgaaaag tccacgcaat acatggcgaa gcgtcgcatt ggagctttga tctctgtggc     1500

tcgtgataca ggcatggacg actacatcga gactggcatt ccgcttaatg cgaaaatctc     1560

atcgcaatta ttgattaata tcttcatccc caatacccct cttcacgatg gcgccgtgat     1620

cattaaaggt aacgagatcg cgagcgctgc cagttatctg ccattgtccg actcgccgtt     1680

tctttctaag gagctgggaa ctcgccatcg tgccgcatta gggatttccg aggtgacaga     1740

ttcaatcaca atcgttgtca gcgaggaaac aggtgggatt tcccttacga agggaggcga     1800

actgttccgt gatgtatccg aagaagaatt gcataagatt ttgcttaaag agctggtgac     1860

tgtcacagct aaaaaaccaa gcattttctc caaatggaaa ggaggtaagt ccgagtga       1918


<210> 1277
<211> 4203
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1277
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttc      900

aatctgtaaa caaatcgaac atcagttgac gaagccagat attggccaaa tccttatggt      960

atttagcgtg ccagaacata ttaatggcaa tctcgggaag cactaccgga tgaggcagag     1020

cggacaagcc gaaaggttcg acacagcaat ccgctaagcg gatcggcact gttgccagca     1080

ggtcagtacg ttgaagaata tggccaacgg ctgcgaaatg gggcacttcc agacgaatat     1140

cacgacggat gcctacacgg gtcatatacg tgtccacttc accgtggcct gtgcctgctg     1200

caataacacg tacatgtcca taactacaaa agcgttcaag cgtcaatggc tcacgggtaa     1260

cggggtggtc cttgcggcac aaacaaacgt agtggttttg cagtaaacgg cgttggaaga     1320

agcctgtttg aaggttgggc agaagcccca ccgccaaatc gacagttcca ttttgcaacg     1380

cctgcattaa tgacatagac gaatcgcgga cagtagaaat gacgcagttc ggtgcttgat     1440

gggcaagtac gtccatcagg cgaggcatga aataaatctc cccaatatcc gtcattgcca     1500

gggtgaaagt acgctccgaa gtaagggggt caaagctctc atgatgttgt aaagcgttac     1560

gaagggcgtg catggcactg gtgacaggct cggccaagtg tgcggcgtat ggcgttggtt     1620

ccatcccttg gtgagtacgg acgaacaacg gatcttgtaa cgatgtacga aggcgtttta     1680

atgcgttaga aactgcgggt tgagtaagcc caagattttc tgcggtgatg gagacgcgac     1740

gatctaccag cagctgatta aagacaacta acaggttaag gtccagatca cgcaattcca     1800

tggggcctcg cttgggttat tgctggtgcc cggccgggcg caatattcat gttgatgatt     1860

tattatatat cgagtggtgt atttatcaat attgtttgct ccgttatcgt tattaacaag     1920

tcatcaataa agccatcacg agtaccatag aggatcgccg catcccacgc taactaatat     1980

aaaggaggtt ttaaatggac ttttccaaca tgagtatcct tcactattta gcgaatattg     2040

tagacatttt ggtggtttgg ttcgtaattt acaaggttat catgcttatt cgcggcacga     2100

aagccgtcca gctgttgaag gggattttca ttattattgc cgtcaagtta cttagcggct     2160

tcttcggatt gcagacagtg gaatggatta ctgatcaaat gctgacttgg ggtttcttag     2220

ccattatcat tatctttcaa ccggaattgc gtcgtgccct ggagactttg gggcgtggca     2280

atatctttac ccgctatgga tcacgcattg agcgtgaaca acaccacctt attgagtcta     2340

ttgaaaagtc cacgcaatac atggcgaagc gtcgcattgg agctttgatc tctgtggctc     2400

gtgatacagg catggacgac tacatcgaga ctggcattcc gcttaatgcg aaaatctcat     2460

cgcaattatt gattaatatc ttcatcccca atacccctct tcacgatggc gccgtgatca     2520

ttaaaggtaa cgagatcgcg agcgctgcca gttatctgcc attgtccgac tcgccgtttc     2580

tttctaagga gctgggaact cgccatcgtg ccgcattagg gatttccgag gtgacagatt     2640

caatcacaat cgttgtcagc gaggaaacag gtgggatttc ccttacgaag ggaggcgaac     2700

tgttccgtga tgtatccgaa gaagaattgc ataagatttt gcttaaagag ctggtgactg     2760

tcacagctaa aaaaccaagc attttctcca aatggaaagg aggtaagtcc gagtgaggag     2820

gaacgattgg taaacccggt gtaataagca tgctaatcag ccgtggaatt cggtctcagg     2880

aggaacgatt ggtaaacccg gtgaacgcat gagaaagccc ccggaagatc accttccggg     2940

ggctttttta ttgcgcggac caaaacgaaa aaagacgctc gaaagcgtct cttttctgga     3000

atttggtacc gaggcgtaat gctctgccag tgttacaacc aattaaccaa ttctgattag     3060

aaaaactcat cgagcatcaa atgaaactgc aatttattca tatcaggatt atcaatacca     3120

tatttttgaa aaagccgttt ctgtaatgaa ggagaaaact caccgaggca gttccatagg     3180

atggcaagat cctggtatcg gtctgcgatt ccgactcgtc caacatcaat acaacctatt     3240

aatttcccct cgtcaaaaat aaggttatca agtgagaaat caccatgagt gacgactgaa     3300

tccggtgaga atggcaaaag cttatgcatt tctttccaga cttgttcaac aggccagcca     3360

ttacgctcgt catcaaaatc actcgcatca accaaaccgt tattcattcg tgattgcgcc     3420

tgagcgagac gaaatacgcg atcgctgtta aaaggacaat tacaaacagg aatcgaatgc     3480

aaccggcgca ggaacactgc cagcgcatca acaatatttt cacctgaatc aggatattct     3540

tctaatacct ggaatgctgt tttcccgggg atcgcagtgg tgagtaacca tgcatcatca     3600

ggagtacgga taaaatgctt gatggtcgga agaggcataa attccgtcag ccagtttagt     3660

ctgaccatct catctgtaac atcattggca acgctacctt tgccatgttt cagaaacaac     3720

tctggcgcat cgggcttccc atacaatcga tagattgtcg cacctgattg cccgacatta     3780

tcgcgagccc atttataccc atataaatca gcatccatgt tggaatttaa tcgcggcctc     3840

gagcaagacg tttcccgttg aatatggctc ataacacccc ttgtattact gtttatgtaa     3900

gcagacagtt ttattgttca tgatgatata tttttatctt gtgcaatgta acatcagaga     3960

ttttgagaca caacgtggct ttgttgaata aatcgaactt ttgctgagtt gaaggatcag     4020

atcacgcatc ttcccgacaa cgcagaccgt tccgtggcaa agcaaaagtt caaaatcacc     4080

aactggtcca cctacaacaa agctctcatc aaccgtggct ccctcacttt ctggctggat     4140

gatggggcga ttcaggcctg gtatgagtca gcaacacctt cttcacgagg cagacctcag     4200

cgc                                                                   4203


<210> 1278
<211> 903
<212> DNA
<213> Pseudomonas sp.

<400> 1278
tcaatctgta aacaaatcga acatcagttg acgaagccag atattggcca aatccttatg       60

gtatttagcg tgccagaaca tattaatggc aatctcggga agcactaccg gatgaggcag      120

agcggacaag ccgaaaggtt cgacacagca atccgctaag cggatcggca ctgttgccag      180

caggtcagta cgttgaagaa tatggccaac ggctgcgaaa tggggcactt ccagacgaat      240

atcacgacgg atgcctacac gggtcatata cgtgtccact tcaccgtggc ctgtgcctgc      300

tgcaataaca cgtacatgtc cataactaca aaagcgttca agcgtcaatg gctcacgggt      360

aacggggtgg tccttgcggc acaaacaaac gtagtggttt tgcagtaaac ggcgttggaa      420

gaagcctgtt tgaaggttgg gcagaagccc caccgccaaa tcgacagttc cattttgcaa      480

cgcctgcatt aatgacatag acgaatcgcg gacagtagaa atgacgcagt tcggtgcttg      540

atgggcaagt acgtccatca ggcgaggcat gaaataaatc tccccaatat ccgtcattgc      600

cagggtgaaa gtacgctccg aagtaagggg gtcaaagctc tcatgatgtt gtaaagcgtt      660

acgaagggcg tgcatggcac tggtgacagg ctcggccaag tgtgcggcgt atggcgttgg      720

ttccatccct tggtgagtac ggacgaacaa cggatcttgt aacgatgtac gaaggcgttt      780

taatgcgtta gaaactgcgg gttgagtaag cccaagattt tctgcggtga tggagacgcg      840

acgatctacc agcagctgat taaagacaac taacaggtta aggtccagat cacgcaattc      900

cat                                                                    903


<210> 1279
<211> 155
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1279
ggggcctcgc ttgggttatt gctggtgccc ggccgggcgc aatattcatg ttgatgattt       60

attatatatc gagtggtgta tttatcaata ttgtttgctc cgttatcgtt attaacaagt      120

catcaataaa gccatcacga gtaccataga ggatc                                 155


<210> 1280
<211> 300
<212> PRT
<213> Pseudomonas sp.

<400> 1280
Met Glu Leu Arg Asp Leu Asp Leu Asn Leu Leu Val Val Phe Asn Gln 
1               5                   10                  15      


Leu Leu Val Asp Arg Arg Val Ser Ile Thr Ala Glu Asn Leu Gly Leu 
            20                  25                  30          


Thr Gln Pro Ala Val Ser Asn Ala Leu Lys Arg Leu Arg Thr Ser Leu 
        35                  40                  45              


Gln Asp Pro Leu Phe Val Arg Thr His Gln Gly Met Glu Pro Thr Pro 
    50                  55                  60                  


Tyr Ala Ala His Leu Ala Glu Pro Val Thr Ser Ala Met His Ala Leu 
65                  70                  75                  80  


Arg Asn Ala Leu Gln His His Glu Ser Phe Asp Pro Leu Thr Ser Glu 
                85                  90                  95      


Arg Thr Phe Thr Leu Ala Met Thr Asp Ile Gly Glu Ile Tyr Phe Met 
            100                 105                 110         


Pro Arg Leu Met Asp Val Leu Ala His Gln Ala Pro Asn Cys Val Ile 
        115                 120                 125             


Ser Thr Val Arg Asp Ser Ser Met Ser Leu Met Gln Ala Leu Gln Asn 
    130                 135                 140                 


Gly Thr Val Asp Leu Ala Val Gly Leu Leu Pro Asn Leu Gln Thr Gly 
145                 150                 155                 160 


Phe Phe Gln Arg Arg Leu Leu Gln Asn His Tyr Val Cys Leu Cys Arg 
                165                 170                 175     


Lys Asp His Pro Val Thr Arg Glu Pro Leu Thr Leu Glu Arg Phe Cys 
            180                 185                 190         


Ser Tyr Gly His Val Arg Val Ile Ala Ala Gly Thr Gly His Gly Glu 
        195                 200                 205             


Val Asp Thr Tyr Met Thr Arg Val Gly Ile Arg Arg Asp Ile Arg Leu 
    210                 215                 220                 


Glu Val Pro His Phe Ala Ala Val Gly His Ile Leu Gln Arg Thr Asp 
225                 230                 235                 240 


Leu Leu Ala Thr Val Pro Ile Arg Leu Ala Asp Cys Cys Val Glu Pro 
                245                 250                 255     


Phe Gly Leu Ser Ala Leu Pro His Pro Val Val Leu Pro Glu Ile Ala 
            260                 265                 270         


Ile Asn Met Phe Trp His Ala Lys Tyr His Lys Asp Leu Ala Asn Ile 
        275                 280                 285             


Trp Leu Arg Gln Leu Met Phe Asp Leu Phe Thr Asp 
    290                 295                 300 


<210> 1281
<211> 164
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1281
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgcaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctctt ggatccaaag tgaa                       164


<210> 1282
<211> 201
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1282
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgcaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctctt ggatccaaag tgaacccgca tcccacgcta      180

actaatataa ggggggcaag a                                                201


<210> 1283
<211> 1251
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1283
atgacgaccc gaaatgattg cctagcgttg gatgcacagg acagtctggc tccgctgcgc       60

caacaatttg cgctgccgga gggtgtgata tacctggatg gcaattcgct gggcgcacgt      120

ccggtagctg cgctggctcg cgcgcaggct gtgatcgcag aagaatgggg caacgggttg      180

atccgttcat ggaactctgc gggctggcgt gatctgtctg aacgcctggg taatcgcctg      240

gctaccctga ttggtgcgcg cgatggggaa gtagttgtta ctgataccac ctcgattaat      300

ctgtttaaag tgctgtcagc ggcgctgcgc gtgcaagcta cccgtagccc ggagcgccgt      360

gttatcgtga ctgagacctc gaatttcccg accgacctgt atattgcgga agggttggcg      420

gatatgctgc aacaaggtta cactctgcgt ttggtggatt caccggaaga gctgccacag      480

gctatagatc aggacaccgc ggtggtgatg ctgacgcacg taaattataa aaccggttat      540

atgcacgaca tgcaggctct gaccgcgttg agccacgagt gtggggctct ggcgatttgg      600

gatctggcgc actctgctgg cgctgtgccg gtggacctgc accaagcggg cgcggactat      660

gcgattggct gcacgtacaa atacctgaat ggcggcccgg gttcgcaagc gtttgtttgg      720

gtttcgccgc aactgtgcga cctggtaccg cagccgctgt ctggttggtt cggccatagt      780

cgccaattcg cgatggagcc gcgctacgaa ccttctaacg gcattgctcg ctatctgtgc      840

ggcactcagc ctattactag cttggctatg gtggagtgcg gcctggatgt gtttgcgcag      900

acggatatgg cttcgctgcg ccgtaaaagt ctggcgctga ctgatctgtt catcgagctg      960

gttgaacaac gctgcgctgc acacgaactg accctggtta ctccacgtga acacgcgaaa     1020

cgcggctctc acgtgtcttt tgaacacccc gagggttacg ctgttattca agctctgatt     1080

gatcgtggcg tgatcggcga ttaccgtgag ccacgtatta tgcgtttcgg tttcactcct     1140

ctgtatacta cttttacgga agtttgggat gcagtacaaa tcctgggcga aatcctggat     1200

cgtaagactt gggcgcaggc tcagtttcag gtgcgccact ctgttactta a              1251


<210> 1284
<211> 1023
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1284
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgcaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctctt ggatccaaag tgaacccgca tcccacgcta      180

actaatataa ggggggcaag aatggacttt tccaacatga gtatccttca ctatttagcg      240

aatattgtag acattttggt ggtttggttc gtaatttaca aggttatcat gcttatccgc      300

ggcacgaaag ccgtccagct gttgaagggg attttcatta ttattgccgt caagttactt      360

agcggcttct tcggattgca gacagtggaa tggattactg atcaaatgct gacttggggt      420

ttcttagcca ttatcattat ctttcaaccg gaattgcgtc gtgccctgga gactttgggg      480

cgtggcaata tctttacccg ctatggatca cgcattgagc gtgaacaaca ccaccttatt      540

gagtctattg aaaagtccac gcaatacatg gcgaagcgtc gcattggagc tttgatctct      600

gtggctcgtg atacaggcat ggacgactac atcgagactg gcattccgct taatgcgaaa      660

atctcatcgc aattattgat taatatcttc atccccaata cccctcttca cgatggcgca      720

gtgatcatta aaggtaacga gatcgcgagc gctgccagtt atctgccatt gtccgactcg      780

ccgtttcttt ctaaggagct gggaactcgc catcgtgccg cattagggat ttccgaggtg      840

acagattcaa tcacaatcgt tgtcagcgag gaaacaggtg ggatttccct tacgaaggga      900

ggcgaactgt tccgtgatgt atccgaagaa gaattgcata agattttgct taaagagctg      960

gtgactgtca cagctaaaaa accaagcatt ttctccaaat ggaaaggagg taagtccgag     1020

tga                                                                   1023


<210> 1285
<211> 59056
<212> DNA
<213> Escherichia coli

<400> 1285
aggcctctcc tcgcgagagg cattttttat ttgatgggat aaagatcttt gcgcttatac       60

ggttggattt cgcccggttt gcgagttttc agcaatttta atatccaggt gtattgttct      120

ggtcgcggac caacaaaaat ctcgacttct tcattcatcc gccgcgcaat cgtatgatca      180

tccgcctcta acagatcatc catcggtggg cgcacctgaa tcgtcagacg atgcgtcttg      240

ccatcataaa tcggaaatag cggtacaacg cgcgcacggc acactttcat caaacgacca      300

atcgcgggca acgtcgcttt ataggtggca aagaaatcaa caaattcgct gtgttctggg      360

ccatgatcct gatcgggtaa ataatatccc cagtaaccct gacgtaccga ctggatgaat      420

ggtttaatac catcatttct cgcatgcaga cgaccaccaa agcgacggcg caccgtgttc      480

cagacataat caaaaaccgg gttgccctga ttatggaaca tcgctgccat tttctgccct      540

tgcgaggcca tcagcatggc aggaatatcg acggcccaac cgtgcggcac cagaaaaatc      600

actttctcgt tattacgtcg tatctcttcg atgatctcca gcccttgcca gtcaacgcgc      660

ggctgaattt tctccggccc gcgtattgcc aactcagcca tcattaccat cgcttgcggc      720

gcggtggcaa acatctcatc tacaatcgct tcgcgttcag cttcactacg ttctggaaag      780

cagagcgaca gattgattaa cgcacgacgg cgtgagcttt ttcccagtcg tccggcaaaa      840

cgtcccagcc gtgccagaat gggatcacgg aactttggcg gcgttaaagc gatacccgcc      900

atcgctgcta cgcccagcca tgctccccag tagcgcgggt ggcgaaagga tttatcaaac      960

tcaggaatgt attcgctatt attttttttc gtttccatgc ttttccagtt tcggataagg     1020

caaaaatcaa tctggtgata gtgtagcggc gcaacttgcc ccgcaccaaa taaaaaagcc     1080

ggtactgact gcgtaccggc tgcgaatgga tgttaattaa tcaaaccgta gctgcggcac     1140

aatctctttg gcctgtgcca ggaattcgcg acgatcggag ccggtcagcc cttcggtacg     1200

cggcagtttt gccgtcagcg ggtttacggc ctgctggttt atccatactt catagtgcag     1260

atgcggcccg gttgaacgtc cggtattacc ggaaagcgcg atacggtcgc cacgtttcac     1320

cttctgtccc ggtttcacca ggatcttgcg caagtgcata taacgcgtgg tgtagctgcg     1380

accatgacga atagccacat aataacctgc tgcgccacta cgtttggcaa ccaccacttc     1440

accgtcaccc actgaaagca ctggcgtacc ttgtggcatg gcaaaatcaa cacctctgtg     1500

tggcgcaacg cgaccggtca ccggattagt acgacgcggg ttaaagttag atgagatacg     1560

gaactgtttc gccgtcggga atcgcaagaa tcctttcgcc agaccagtac cgttacgatc     1620

gtagaatttg ccatcttcag cgcggattgc gtaataatct ttaccttctg aacgcaaacg     1680

tacgcccagc agctggcttt gctcacgttt accatcaagc atttctcgtg acattaacac     1740

cgcaaattca tcgccttttt tcagtttgcg gaaatccatt tgccactgca tggctttaat     1800

cactgcgctc acttcggcgc tggttaaacc ggcgtttctg gcgctggcaa caaagcttcc     1860

cccgacggta cctttcagca gattgttgac ccactctcct tgctgcattt cgctggtcat     1920

tttaaaaccg ttagcggcag tacggtcata ggttcgggtt tcacgacgag acacttccca     1980

ggtgaggcgc tgcagttcgc cgtccgcggt taatgtccag gagagttgtt gaccgatttt     2040

caggttacgc aattctttgt cggcagcagc cagttgggtg atatcaccca tatcaatacc     2100

atactgattg agaatgctgc ttagcgtatc gccagtggaa acaacatatt catgcacgcc     2160

cgcttcaccg gcgattttgt catccagttc gtcctgggga atggcttcat cttcttgtgc     2220

agcttgatca atcggctcac tggcttcagg taagagcgaa cgaatttcgt tctgttccag     2280

ctcaatggtt ttgacaattg gcgtggcatc gcggtgataa acatagggcc gccagacagc     2340

gacggccaga gtaagaacgg tgagcgaccc caacataacg cggtgtggtc gcggtaaatt     2400

attaaacgcc agggcgacag agcgggctat ctgttgcacg taatcacttc ctcattaatc     2460

tcctttcagg cagctcgcat actggttggc taattgattc aggaattctg aatagcttgt     2520

tttacccagt ttgatattcg tccccagggg atccaacgtt cccatacgaa cggatgtccc     2580

tcgtgcgacg ctctcaacga ccgctggcct gaactgtggc tcagcaaaaa cgcaggttgc     2640

tttttgctca accaactgtg ttcttatttc atgtaaacgc tgcgcgccag gttgaatctc     2700

agggttaacg gtaaaatgac caagcggtgt cagtccgaac tgtttttcga aatagccgta     2760

agcatcgtga aaaacgaaat aacctttccc cttgagcggc gcgagctcgt taccaacctg     2820

cttttcggtt gaggctaatt gtgcctcaaa atccttcagg ttggcgtcaa gtttggctcg     2880

actttgcggc ataagttcca ctaattttcc atggattgca accgctgtag cccgcgctat     2940

ctctggggaa agccaaagat gcatgttgaa atcgccgtga tggtgatctt cgtcactttt     3000

ttccgcgtgg tcgtgatcat catcatcgcc gtgaatactt ttcatcagca gcggtttcac     3060

attctctagc tgcgcaatcg ttacctgttt cgcttcaggt aatttactta ccggtttttg     3120

catgaacgct tccatctccg ggccaaccca aacgactaag tccgcgttct gtaagcgttt     3180

tacatctgat ggacgcagtg aataatcatg ttctgaagcc ccgtcaggta gtaaaacctc     3240

cgtttctgtt accccatcag caatggcaga agcgatgaac ccaacgggtt taagcgaagc     3300

gacaacggca gcatctgcgg cctgtgttgc accgccccag agagcggcgg ataatgctgc     3360

gaaaagaagc gtttttttat gtaacataat gcgaccaatc atcgtaatga atatgagaag     3420

tgtgatatta taacatttca tgactactgc aagactaaaa ttaacatgac aagtctggtt     3480

tccctggaaa atgtctcggt ttcttttggc caacgccgcg tcctctctga tgtgtcgctg     3540

gaacttaaac ctggaaaaat tttgacttta cttgggccaa acggcgcagg taagtcgaca     3600

ctggtacggg tagtgctcgg gctggtaaca cccgatgaag gggttatcaa gcgcaacgga     3660

aaactgcgca tcggctatgt accgcagaag ctgtatctcg acaccacgtt gccactgacc     3720

gtaaaccgtt ttttacgctt acgccctggc acacataaag aagatatttt gcctgcactg     3780

aaacgtgtcc aggccgggca tctgattaac gcaccgatgc aaaagctctc gggtggcgaa     3840

acgcagcgtg tactgttagc gcgagcattg ttaaatcgac cgcaattatt agtgctggat     3900

gaacccactc agggcgtgga tgtgaatggt caggtggcgt tatatgacct tattgaccaa     3960

ctgcgtcgcg aactggattg tggcgtttta atggtatctc acgatctgca tctggtaatg     4020

gcaaaaaccg atgaagtgct ttgcctgaat caccacattt gttgttccgg cacaccggaa     4080

gttgtttccc tgcatccgga gtttatttct atgtttggtc ctcgtggtgc tgaacaactg     4140

ggtatctatc gccatcatca taatcatcgt cacgatttac agggacgaat tgttttgcgt     4200

cggggaaatg atcgctcatg attgaattat tatttcccgg ttggttagcc gggatcatgc     4260

tcgcctgtgc cgcgggtccg ctgggttcgt ttgtagtctg gcgtcgtatg tcttatttcg     4320

gtgatacgct ggctcatgcc tcattacttg gcgtcgcgtt tggtttgttg ctggacgtga     4380

atccattcta tgcggtgatt gccgttacgc tgctgctggc gggcggtctg gtatggctgg     4440

agaagcgtcc acagctggcg atcgacacgt tattagggat tatggcgcac agtgccctgt     4500

cgctgggcct ggtggtcgtt agtctgatgt ctaatattcg tgttgatttg atggcttacc     4560

tgttcggtga tttactggca gtgacgccag aagatctcat ctctattgcg attggcgtgg     4620

tcatcgtggt ggctattttg ttctggcaat ggcgcaattt gctgtcgatg acgattagcc     4680

cggatctggc gtttgttgat ggtgtgaaat tacagcgcgt gaaattgttg ttgatgctgg     4740

tgacggcatt gacgattggt gtagcgatga aattcgtcgg cgcgttgatt attacttcac     4800

tgctgattat tcctgctgct actgcacgtc gctttgcccg cacgccggaa cagatggctg     4860

gtgtcgctgt tttggtgggg atggtggcag tgactggcgg tttaaccttt tccgcatttt     4920

acgatacacc tgcaggcccg tcggtggtgc tatgcgcggc actgttattt attatcagta     4980

tgatgaaaaa gcaggccagc taatctgtcg ctgaacacat ttgtcggatg cggcgcgagc     5040

gccttatccc acctgcggtt cgctatctct ggtaggcctg ataagacgcg aacagcgtcg     5100

catcaggcac actgccagtg tcggatgcgg ctcgagcgac caatccgact tacggcattt     5160

ctggcggcgt gatgccgaag tggttccacg cccgcactgt cgccatacgc ccgcgcggtg     5220

tacgctgcaa aaagccttgc tgaatcaaat aaggttccag tacatcctca atggtttcac     5280

gttcttcgcc aatggctgcc gccaggttat ccagacctac cggcccacca aagaacttat     5340

cgattaccgc cagcaacaat ttgcggtcca tataatcgaa accttcagca tcgacattca     5400

acatatccag cgcctgagca gcgatatctg ccgagatggt gccatcgtgc ttcacttcag     5460

cgaaatcacg cactcgacgc agcagacggt tggcaatacg tggcgtaccg cgcgcacgac     5520

gagcaacttc cagcgcgccg tcatcactca tctcaagccc cataaagcgt gcgctgcgac     5580

tgacgatata ttgcagatcc ggcacctgat aaaactccag acgttgcaca ataccaaaac     5640

gatcgcgcaa cggtgatgtc agcgaacctg cgcgcgtggt tgcaccaatc agggtaaacg     5700

gcggcaaatc aattttaatg gagcgtgccg ccggaccttc accaatcatg atatccagtt     5760

ggtaatcttc cattgccgga tacaacacct cttccaccac tggtgaaaga cggtggatct     5820

catcaataaa cagtacatcg tgtggttcaa ggttagtgag cattgctgcc agatcgcccg     5880

ccttttccag caccggacca gaagtcgtgc gtaaattaac gcccatttca ttggcgacaa     5940

tattggcaag cgtagtttta cccaaccccg gaggaccaaa aatcaataga tgatcgaggg     6000

catcgccgcg cagtttcgct gctttgatga aaatctccat ctgcgaacga acctgcggct     6060

gaccaacata ctcttccagt aatttagggc gaatggcgcg atctgccaca tcttccggca     6120

aagtggtacc ggcagaaatc agacggtctg cttcaatcat cctttacctc ataacgcggc     6180

gcgtagggct tcgcgaatta atgtttcact gctggcgtca gggcgagcga ttttgctcac     6240

catgcggctt gcttcttgtg gtttatagcc cagtgccacc agcgcagcaa ccgcttcctg     6300

ttcagcatcg tcggtcgccg ggctggcagg agacgtgagt accaggtcgg cggctggcgt     6360

aaagagatcg ccatgcaaac ctttaaatcg gtctttcatt tcgacaatca agcgttcggc     6420

ggtttttttg ccaatacccg gcagtttcac cagtgccccc acttcttcac gctcaacggc     6480

attaacgaac tgctgcgctg acattccgga gaggatcgcc agcgccaact tcgggccgac     6540

gccgttggtt ttgatcaact ctttgaacaa cgtgcgctct tgtttattgt taaaaccgta     6600

cagcagttgc gcgtcttcac gcaccacaaa gtgggtgaaa acgatcgctt cctgacccgc     6660

ttcagggagt tcataaaaac aggtcatcgg catatgcact tcatagccta cgccgcccac     6720

ttcaattaac accagcgggg gttgtttttc aatgatgatg cctctgagtc tgcctatcac     6780

atgacgctcc tgcgtaatga atcaaagata atgctgtatg ataaaaaaat gctggataga     6840

tatccagcga aggatgaaga aaacttgcga ggtgtctcga tgatctgaaa aatggcgcag     6900

tataatttat tctacagatt atattggaag caaatattta aatattacat attcagcgaa     6960

gaaatgtgta ataaaaatac acattgcgac ccctgaaaaa aataaatttt ttatgctatt     7020

acgtatattc atatctattt caatggaatg acaacgtgaa tattaattat cctgctgaat     7080

atgaaattgg tgatatcgtc tttacatgta taagtgctgc cttatttggt caaatatcag     7140

ctgcatcaaa ttgctggagt aatcacgtcg ggatcattat cggtcataac ggtgaagact     7200

ttctggttgc agaaagccgt gttcccctct caaccatcac tacgctatcc cgttttatta     7260

aacgctctgc taatcaacgc tatgctataa agcgattaga cgccggacta acagaacaac     7320

aaaatcaacg aattgttgaa caggttcctt cccggctacg caaaatttac cacaccggtt     7380

ttaaatacga atcttcgcgc cagttctgtt caaaatttgt ttttgatatt tataaagagg     7440

cgctatgtat tccggtgggt gaaatagaga cgtttggaga attgttaaat agcaatccaa     7500

atgcaaaact cactttctgg aaattctggt tcttaggttc tattccgtgg gagcgtaaaa     7560

ccgtcacgcc agccagtttg tggcatcatc cgggtttggt gttgattcac gcggtgggag     7620

ttgaaacgcc tcagcctgaa ctgaccgagg cggtataact taacgcagtc gccctctcgc     7680

caggttcagt cgcgattcgc tcatttgcat cgcattctga ctaacgtggc agtgggtgat     7740

ggcaatcgcc agcgcatcgg cggcatccgc ctgtggatta gcgggcagtt tcagcaaggt     7800

gcggaccata tgctgcacct ggcttttttc ggcactacca atacctacca ctgtttgctt     7860

tacctgacgt gccgcatatt caaataccgg caattcctga ttcaccgccg ccacaatcgc     7920

cacgccgcgc gcctgcccca gtttcagggc tgagtcagcg ttcttcgcca taaagacctg     7980

ttcaatggcg aaataatcag gctggaattg ggtgatgatt tccgtcacgc ccgcatagat     8040

gagcttcaga cgagacggta aatcatccac tttggtgcgt atgcatccgc tacccaggta     8100

ggacagttgc ctgcctacct ggcggatgac gccatagccg gtcacgcgcg aacccgggtc     8160

aatgccgaga ataatagcca tcacgcgtct ccgttttgct gtttagcagg cctcatcaga     8220

gagtcgctgc aacctcatca gagatttcac cgttatggta aacttcctgc acgtcgtcgc     8280

aatcttccag catatcgatc agacgcatca gtttcggtgc ggtttctgca tccatatcag     8340

ctttggtgga cgggatcatg gaaacttccg cgctgtctgc tttcagacct gccgcttcca     8400

gagcgtcgcg tactttgccc atttcttccc atgcagtgta gacatcaatc gcgccgtcat     8460

cataggtcac aacgtcttca gcaccggctt ccagggctgc ttccatgatg gtgtcttcat     8520

cgcctttctc gaaggagatc acgccttttt tgctgaacaa ataagctacg gaaccatcag     8580

taccgaggtt accgccacat ttgctgaatg catgacgcac ttcagcaacg gtacggttgc     8640

ggttgtcaga cagacattca atcatgattg ccgtgccgcc aggaccgtaa ccttcgtaga     8700

tgatggtttc catgtttgca tcatcatcac cgcccacacc tcgtgcaatt gcgcggttca     8760

gagtgtcacg ggtcatgttg ttagacagtg ctttatcaat tgctgcacgc aaacgcgggt     8820

tagcgtccgg atcaccaccg cccagcttag ccgcggttac cagctcacga atgattttag     8880

tgaagatttt accgcgctta gcatcctgcg cagctttacg atgtctggtg ttggcccatt     8940

tactatgacc tgccataaaa atatctccag atagccctgc ctgttcaggc agcgttaatt     9000

acaaactgtt caatcgcctg ccggttgctc caggacttag tgagcgccgc cgcagcagac     9060

gcatcaagcc acttgtaagc cagatgttca gtgaaaacga tctggcgctc gtgcggaagc     9120

gcaagacaga accatgattc cgtattacgc gtcacgcccg gcgcatagcg atgacgtaaa     9180

tgtgaaaaaa tttcaaactc taccgtgcgc tgacagtcaa ttaaggtcag ttgttcagcg     9240

acaacatcaa tggtgacctc ttcctttact tcgcgcatgg cagcttgcgg cgcggtttca     9300

ccctcttcca cgctgccggt taccgactgc cagaaatcgg gatcgtcacg ccgctgcaac     9360

atcagcaccc gtttcgtatc ttgtgcgtag atgaccacta agatcgaaac gggacgctta     9420

taagccatat cagttattct cagccttctt cacaacctga atgctcagct cagccagtgc     9480

agtcgggtta gcaaagctcg gcgcttcagt catcaaacac gctgccgccg tggttttcgg     9540

gaaggcgata acgtcacgga tattgtcggt gccggtcagc agcatcgtca gacggtcaag     9600

accgaatgcc aaacctgcgt gcggcggagt accgtatttc agggcgtcga gcaggaagcc     9660

gaatttctcg cgctgttcct cttcgttgat acccagaata ccaaacaccg tctgctgcat     9720

atcaccatta tggatacgca cagaaccacc gcccacttcg taaccattga tgaccatatc     9780

gtaagcgtta gccaccgcat tttccggtgc agctttcagt tctgctgccg tcatgtcttt     9840

cggtgaggtg aacggatggt gcattgctgt caggccgcct tcaccgtcgt cttcaaacat     9900

cgggaagtcg ataacccaca gcggtgccca tttgctttcg tcggtcagac caaggtcttt     9960

acccactttc aggcgcagtg cgcccatcgc gtcggcaaca attttcttgt tgtcggcacc    10020

gaagaaaatc atatcgccat cttgcgcgcc agtacgctcc aggatggctt cgatgatttc    10080

tgcattaagg aacttcgcta ccgggctatt gataccttcc agacctttcg cgcgttcgtt    10140

aactttgatg taagccagac ctttcgcgcc gtagatttta acgaagttac cgtattcgtc    10200

gatctgctta cgggtcaacg atgcgccgcc cggaacacgc agagcggcaa cacggccttt    10260

cggatcgttc gccggacctg caaatactgc aaactcaaca gatttcagca gatcggcaac    10320

gtcggtcagt tccatcgggt tacgcagatc cggtttatca gaaccataac ggcgttctgc    10380

ttctgcaaag gtcattaccg ggaaatcgcc cagatccacg cccttcactt ccagccacag    10440

atgacgcacc agcgcttcca tcacttcacg cacttgcggc gcggtcatga aagaagtttc    10500

cacatcgatc tgagtaaatt caggctgacg gtcagcacgc aggtcttcgt cacggaagca    10560

tttaacgatc tgatagtagc ggtcaaagcc ggacatcatc agtagctgtt tgaacaactg    10620

cggggattgc ggcagcgcgt agaatttacc tttgtgcaca cgagaaggca ccaggtagtc    10680

acgcgcgcct tcaggcgtgg ctttggtcag catcggagtt tcgatgtcga ggaagccgtg    10740

gtcatccata aaacggcgca ccaggctggt gattttagcg cgggttttca ggcgctgagc    10800

catttccggg cgacgcaggt cgaggtagcg gtatttcaga cgcgcttctt cggtgttgac    10860

gtggttagag tcaagcggca gaacatctgc acggttgatg atagtcagcg aggacgccag    10920

tacttcgatt tcgccagtcg ccatatcgcg gttaatattt ttttcgtcac gcgcacgtac    10980

ggtgcccgtg acctgaatgc agaactcatt acgcagttca gaggccagct ttaacgcgtc    11040

cgcacgatcc ggatcgaaaa atacctgcac gataccttcg cggtcgcgca tatcgatgaa    11100

gatcaggcta ccaagatcac gacgacggtt gacccaacca cacagagtca cctgctgccc    11160

cacgtgggac aaacggagct gtccacaata ttctgtacgc atgagatatc ccttaactta    11220

gctgccggcg gatgccccct gctgcgcagg tgaccaagtc gcagcgttag ctgtatgtca    11280

caactgaatg aaaaaaggcg gctattatac tggaaattct gccgcaccgt aagagcctgg    11340

cccgcgctgg aacgcctcgt taccacttta tatcgggcct gaaatcagac tctacgccag    11400

tttgctataa aggtgttgcc cgaactcata aaaattaaca aaatttgtcg ttccgccatc    11460

ggctaatcgc attaaggtga gaggcacgat tttgttttgt caggagtcat catgcttgaa    11520

cttaatgcta aaaccaccgc gctggtggtg attgatttac aagaaggcat cttgcctttt    11580

gccggaggtc cacatactgc cgatgaggtg gttaatcgcg ccgggaagct ggcggcgaaa    11640

tttcgcgcca gcggtcagcc cgtgtttctg gtgcgcgttg gctggtctgc cgattacgcc    11700

gaagcattaa aacagccggt tgatgccccc tcccccgcaa aagtgttgcc cgaaaactgg    11760

tggcaacatc ctgctgcatt aggtgcaacc gacagcgata tcgaaatcat caaacgtcaa    11820

tggggtgcgt tttacggtac ggatctggag ttgcaattac gccgccgggg tatcgataca    11880

atagtgttat gtgggatctc gaccaatatc ggtgttgaat ccaccgcccg caatgcctgg    11940

gaactcggtt ttaatctggt gattgccgaa gatgcctgta gcgccgctag cgccgagcag    12000

cacaataaca gcattaatca tatctacccg cgcatcgccc gtgtgcgtag cgttgaagag    12060

atcctcaacg cgttatgatt tacatcggtt tgccacaatg gtcgcatcct aaatgggtgc    12120

ggttggggat caccagcctt gaagagtatg cccgccactt taactgcgtg acgcgggcat    12180

tttaaaaatc actaaagaac gcccaagagc atgtgttttc tttagtttat tcaatgcatt    12240

aaaaaatagt ttcgcatgaa attcggtaaa cttcatgtgt gcaataatgt cccattcatg    12300

ccccaaaatg ccccaaagca gacatttttg ccccaagtat gccccacaag tcacgtcttc    12360

aagtcgtcta tatccatagc acaccgagtt acattcttgc atccggggtg tcgacaatac    12420

ctactttatt gagtgtgcga gaattaccag gaacctttcc acaatgtagt agtctaatag    12480

tcgaatccat ctaacattaa gaagcgttat gatcactagc ctctcattga tatcttctgt    12540

aatagtcact ctatgtatca tggtgttcgc tacagtaaag gtagggattg gtttgtctaa    12600

caatccagac agaaatgata attaacctca accacgtaac cacacttcat acttcatact    12660

tcacttaaca gtgaagtgct cacatcaccg ggcagtcatc aaactccgca ttcctggcat    12720

cattaatgat gtacgtgatc actccaaata tagcgggtgc agaactgtaa ccatcatcat    12780

ctgctggcag cgcttccctt ctcccgttat ccagattaac caggtgcggc tgaggatgag    12840

tccgatatcg cttgatcctg aattccccgt cgattgcaca tatcagcagt gaaccatcgc    12900

aggcagtaag tgacgcatcc acaacaagca acgctccctg gattatccct tccctgaaat    12960

gtgaacgcga tgcccgcatg aaataagtcg ctgcgggctg actgattagc tgctgatcga    13020

gggagattcg tgtttcaaca taatctgccg caggtgaagg aaatcccatg tttacgccct    13080

ctcttgaata ccggataaaa acacagtata aatactgtat atccatccag caaagaggca    13140

atgagcaatg ttcgtggaac tcgtttatga caaaaggaat tttgatggtc tgcccggtgc    13200

aaaagatatc attctgggcg agttaactaa gagagttcac cggatcttcc ccgatgctga    13260

tgttcgggtt aaaccgatga tgacactgcc ggcgatcaac actgacgcca gcaagcatga    13320

gaaggaacag ataagccgta ctgttcagga aatgtttgaa gaggctgaat tctggttagt    13380

gagtgagtaa agattttcaa tgcccgccac agttacgtat tgattatgct gtggaggata    13440

ttcattttcg taaacgttgg tttgggagaa gcggcaaaac ggaatgtggg aacaggggaa    13500

aatcagatac cagatatgtc tgcatttcca tctggcaata actggtttca gttaccaagt    13560

ggacatatcg ttcagatatt ttccatgaac gttcttggtg cagatgctaa tggcacgtca    13620

gctaattacc ccattgcttt tccaacaacg atgattgctg tcagtgctct atggtctgat    13680

gggactgtag caaatgcacc gacatacaag atgatgggga acacgactaa cagaacaact    13740

ttgacgataa aagtatcagc cagctcaggt acttacggga caatgattat tgcggtggga    13800

cgataatatg aataaataca gttactctcc ttcagaaaat gccttttatg ctgttgcgtt    13860

aaaaaatacc tatgaattga gtggcacatg gccagctgat gcattagata ttcctgatga    13920

catttctgta aaatatatgg cggaaccgcc acaagggaaa atccgagttg caggggaaaa    13980

tggttttccc acatgggctg aaatacctcc accatcacat gaggaactta ttgaacaggc    14040

cgaatcagag aggcaattat tgattaacca ggccaacgaa tacatgaaca gtaaacaatg    14100

gcccggtaaa gccgctattg gtcgtctgaa aggcgaggaa ctggcacaat ataattcgtg    14160

gctggattat ctggacgcac tggaactggt cgatacttcc ggtacgcccg atattgaatg    14220

gcctacgcct ccggcagttc aggccagatg acatccggcg cggtgctggt atctgttgca    14280

gtcaccgcgt caatgtaatc cagcacggcg ttaagtcggg ttgtttctgc ctgagtcagt    14340

ttccgtccgg cctgtaattt cagctgaatc agactaatgg aagccattgc tgcatcaatc    14400

agtgattggc gctgtgcttc tgccgcttct actgaggcac cgtgttgtgc ctcagtatct    14460

gtcacccatt tctcaccatc ccatttatca tatggcgtta acggtgaaag cgtgacataa    14520

ccgtttttga tggcaccgat ataatccact gtaacagctg cgccattttc gattgagtaa    14580

acagtctcat tgcgatggtc ttcctcatgg ctccatccct tacctgtaaa tactgccact    14640

cttcccggaa tgttttcgtc cgggtcaata ccagtggaac aggcgggcat acttacgcca    14700

gtattaatat attcatcaga ccagcccgta tattcagacg ttactgcatc ataataaaaa    14760

caacgcatat cacccggcac tgcagccagc ccattttcat caaaaacagg tttcattatt    14820

tagccctcac cagaaagtta aatgcaatat ttcgcggtct gacagcaaca aaattcacac    14880

catcacccac agagttactg ttgaaattaa atcgtgaaaa tcctggctga tttccggcga    14940

tgccatcatg aaagttaatt gcgtgtccag cacctccgcc tatattcccg gcaaactgag    15000

aaaagtttgt agcttcctgc cagcttaata attcgcgacc accatctgca cctcgcccgt    15060

catcccagac acgaatgaaa tcaccgcggg cttcaggtaa taccagcgaa ggaaacactt    15120

tcgccagcac aggataatca gtggcagaga atttcgcgcc gttgaacttc aaaaacacca    15180

tactggacca gctgtcgatt acagtatttg gcattgcagc ggacggccag aagaacggaa    15240

cgccaatagc tggagaacct tctcccaaac caaggtttgt gcgagcgtct gcggcattcg    15300

ttgcgccggt tccgccgtct gcgacagtaa ccgcaccgtt gctccctttc tgcgcaagtt    15360

taccgatgcc tgggatggtt acggcggtgc cgttgatggt aactgtgatg ctttggtttg    15420

ctgaggtggt ggcgaacgtc tcccacgcgc caatattctc gtcgtactct ttgatgagct    15480

gtgacatggc ctgcgccagg ccgtcgactg agatattgtc cgacacaagg attccatact    15540

tctggccgct cagcgccggg gaaactgctg gcgtaaccgt cattgacgtg gcgctgttca    15600

cggatgaaat ctgaaacagc tgcaccgggt tagacatcac gataatcgtc tggccagcgc    15660

ggacctggct ggcgggagct gtccagtttg tgccggagcc ggttgcggta tttccgttaa    15720

tagagatagt tccggtgcta taaatcataa caactcctaa atttagacaa catgaagccc    15780

ggagaggtat ataaccctca ccagaaataa tttctgaatt ggtttttaat acatgttggg    15840

caacgccagt gttggcatag ctatagttgt atcaaatgcc attgaccacc cacccaaata    15900

ataattgccg actactttat tcctttctgc tctgacattc ccacctgtca ttacaattcc    15960

tttataccta atatttccgt aaccaccaac gtgtcgacag ttagccccgg tataaacaat    16020

ctggcaaaat tcatcaccaa tattcaggtt cgcattggcg atatttattg tcccatcaaa    16080

aatgaatggc ttcgtgcaag taagaagacg tttgcgttga cgattggttt attcaatcca    16140

tcaactaaaa tatcatgtaa acgaattgcc ataacatttc ccactttatt ttacttactc    16200

aacacaacaa gtatattaaa attgaacctt gtcaacaaca caaaggagtc ccaatgaaac    16260

tcgctctaat tatgctgcca ttatgtctgt ccctcactgc atgtggtaat ggtttaaata    16320

ccggtaaacc aaattccggt gtcattccaa aacctttgga tcgagatggt aacggttctt    16380

taatttatga taccgaaaac cttccaatga cggggcagtg gtgtcacgag attgatcacg    16440

aataccgacg aatcggtagc ccttctaact gtgttataga ctactaaata ttaacccctc    16500

aaaagagggg ttaatatttt aacctgtgaa tgaaccagat ccgtgtgata ctatgatagt    16560

aggcgaagaa attgacgcac ccctgttatt ttgagcggac actttaatac gcactgttac    16620

gtttggacct gttacaaccg cagaatgcat gataagtctc tccatgtctt gcacggatga    16680

accactctca ttgccgttaa tgtcgattgt tcctgcacca ttacctttaa cgtttgctat    16740

aacacagacg tgtcttgcgt gcccagaact ggatgaatca ttataagtca ttaccttttc    16800

taaatatccg tcactagacc gactcacatt cgtccctgtg tgcatatttg caatgtcccc    16860

gataaaactt tgggcttcca cagtcccttt gaatttaccg cttgttgctt ggatctcacc    16920

agtaaagcta ccgccactag catatactac acctctgacg gtcacattgt tgaattcagc    16980

atctccagct ttattcaact tccaaccagc agaaccagct gcatagttgt tggactggat    17040

atagttaccg atttttgcgt tctcaatggt gccgtcctgg atgaagctgg cccggatgaa    17100

tgtctgcccg ttctggatca cgaacggcaa agctacgcta tttccggctg ccgtggtgac    17160

ggcgaagcgg tcagccagga agataacctg cgactgcatg ccggatggcg tattctccac    17220

gccgataccc atccccgcgg cgtaatactg cccgttgctg gagacaccaa ccttgatgtt    17280

gtacatcgcg ctgagttcgc cattaacgtt ggctatagcc tgagcgttag tggtgatggc    17340

ggaggtatgc ccgttcacgg tcgccgtgat gccgtttatc tgcgtggcgg tggcctgctg    17400

atagtcggag agcgtctgat tcaggctgtt gatggatgcc ttgttgccgt tgacgtccgt    17460

ctgcaggctc agcaatgaac gtgctgtggc ttccttctca ctgacgatca cctcgtcgag    17520

acggtccaga ttcgcgctgt tgccggcgac cgatgcagaa agggttttac gcgtggccac    17580

ctgagcgagg ttggcctgga ttatcgcaat tgcagagttc ttcaccccgc ccgtcatgcc    17640

gtccatagaa acgctgatgt tgtcgattcg ctggcccagg gcggtatcag ccgtcgcaac    17700

ggtctgctca agctgactga gtgaagacga aacattcccg accgtgctgg aaagctcatt    17760

aacgctggtc tgaaccttcc cgacgtcctg ggcatttttg gcgatatctt tcgcttgctg    17820

ctccagttcg tcgttggcct gtttgatatc gttagccatg ccagcaattt tttcgttgct    17880

gtccaccgcg ttctcgatca ggtctttgaa cgtttccgac tctttcatat cctccagaat    17940

gtcattagtt atttcgctga catctatcga ggacgtgccc atgatccagt cggtccagtc    18000

cccggcgtta ccgatacggt caatcaggcg cgcgcggtac cactggcgaa cgccggcagg    18060

catggggcca tgctgataat ctgcagccgg gtacggcacc aggaccagca gttcaggatt    18120

ggcgtagtcg gcagttgtgg cgcgctgaat ctctgtatag gccgtgtcgc ctgagccatc    18180

cggaaatttc caggtcaggt cgatatgcca gaccacatct tcggtcgcca ggaagttgag    18240

cggagtaccc ggttttcccg ttttaccgga gagataagtt gtttcaccgt atccccatgg    18300

tgacgacgta tcctgcgcat tcagcgcccg tacgcgcacg tcatagctgc ccgaataaat    18360

gccctgaacc gagaaaccct gcgcgctggt aaccggaacg tttatccagt ccccgttgtc    18420

cttacgccac tgggcaacat accggattgc gccctctacc ttatcccatg acacgtccag    18480

gcttgctaca gtcagcccct gagacacatg atcgctctca gtcaccacga tattcttcgg    18540

agcagacagg acgcttatcg gcgtgacggt gatcggggga gactcgaccc gaacgccgtc    18600

atcgatgtaa cgatatttgt ttggatcgtg ctgaacggcc gtaatagtga aaccgcctgt    18660

actgtcgtcg ttagccgcga ttgaggtgac cctgaagtac tgtattgcga ggttatcact    18720

gtctatcgcc caaacagcgc ccgccacagg aacctgactg aatgccgtag ccaccgtcac    18780

cgttttttta tcggcgctca ccgcgctgat tgtccgcgtc tgggcttttc cgtcgggaag    18840

gttaaccacc agccggtctt tcgccgcgta gtctatttct cgatcgaggg taatttggcg    18900

gccgttggcc gcgcttatac ggcccccgtt ctccttacca gagcggaaag gatcggcgac    18960

accgataatt tcagcgggca aagggatata accgtccagc cccacgccaa acgatacggt    19020

cccgtctttg gcattggaga gcaataccca gcgaccgcgt cggtgcgctt cactttgcga    19080

ggtgcagccg attgcggtca gggacgtctg ccggacgtcg taacgttcta caagcgccga    19140

atcgtaaacc ccctcaacgg tatcgctgta atggttctgc ggatcggacc aggacaccag    19200

gcaggagctg tagcgattct tgtatgagcc gcccgcataa gtaaacagcc catcgataac    19260

gtttgagacg ttataaaccc agtcaacatc gtcctgcggg acgtctgcct ggacataaat    19320

ctgatcgttt ccccagaacg ttattccacg aaataccgcg gcgagatcgt taagtacctg    19380

ccaggcgtcc tcctggctct gaatgaaaac gttgcaggtg aaacgcggtt cggtgccacc    19440

ggccccgtcg gaaaccattt cgtcacagta ctgggcgatt gaatacagcg cccacttatc    19500

caccatggac gcatccacgc gcgtgcccat gccgtaaatt tcatccagaa ccagatcgta    19560

aaagatccag gcagggttat tggaccatgc cattttgaac ccgccggacc atgaaccaga    19620

ataggttcgg gttttcggat cgtaattatc cggaacctta atcagcttgc cttttatctt    19680

acaggtcact ttcggcgcgc tgccgttgaa ttggctgctg tccacttcga catacaggag    19740

cgctgttaaa ggataacgaa gcttgctgtc gatgacttcc gcatacgaaa acaccttgaa    19800

ggcgttaacc agtttcgaat ttgatccgct ggcatcagcc gtaatacgcc tgaccctgac    19860

agaccagccg gacgtggatt ttggcagatc gatacggtgg tcacgctgat attccgtcgt    19920

ggtctttccg tcaaacttgc cgtttacaac cgttttccag gcgccgccgt ccgttgataa    19980

atcgatcgca tactcggtga ccgtgcccac catatcgcca ttatctttat agagatactg    20040

gaccggaagg ctgagcttga tacggatggc atccagggaa aggtttgtaa actggcgcgt    20100

ccagggcgcg gtggtggtga cagttgtgcc cacggccagc tcgttgtcga cctggggcat    20160

cccggcaata taggtctggt cctgtgtgcc cttgcggaac tcccatttca cgccgctgaa    20220

gttgtattcc ccgctgtcgt ttgccagcgg cgtatcgttg agaaaaatgt tctgagcggt    20280

caggtcgccc tgtatttccc cctcagaaac ggcaatgagc atttttaatt ttgcgaccga    20340

cagcagatcg tcaggctgct caaccggagt atgtgaactg ccacctcccc ctttggcacc    20400

ctgcaggatg gtttcttgtt taagaagctg cattttttca cccataaaaa aaggtgccga    20460

agcaccttta agttagtggc cgctggccta ctgctgatcg ctcgagtaca taccggcgct    20520

gactatcgct ccccctgcct cagtcagacc gtaggccagg gggacaggat gccccatagc    20580

gacggtattg accggcgccc cgaaggcgta gttaggcgtg ttgtccgtgc tggaggattt    20640

acccgcgccg aaggatggct ggggcgtgag catctggaca acgcccccca gcatcatcga    20700

cactccgacc cctgtcagaa ttgacgtggc gctgatagct gttgcactca tcgccgcgcc    20760

ccaggctgcc atgctcgcac cagcggtaaa gaatgcagcg accagcgcaa cagccccgac    20820

aactatctgc aggacgcccg aacttttggc cccctcataa acgggcacga tccggtacac    20880

gcttccaccg cgggtcatat caaactcttc cagcccgata ttgttgccac cgttaaaaaa    20940

ggcgaaacgg atccccttca tatgagcttc agacatatat tttttgaatc cgggaacctg    21000

tgaacacatg gccctgagca tctcgcgcag gtcggcaaca tcaaactgaa cgcgtttacc    21060

gaattttttt gccattttac cttcgagaat aagcgtctta accatgcatt ctgtccttat    21120

gcctgaccac ccggaccgtt ctgtcgcgat aatattttcc ataaggcgtt cgcgaagaaa    21180

ggtgcccgaa aagatgatgg agaatgatgt tatcacccac atataccgcg gcgtgattag    21240

tcaccgatgc ctgcacactc atcatgatga tatctccggg ctgcattgca ccggcggcaa    21300

tctcaacgaa tccctcacgc tcccagttgt cgtcgtagag acgctccttg ccgctctccc    21360

accattcgta aggtactgaa taattgccga gaacaatgcc gtattcgcgc agataaaatt    21420

cacggataag cgaccagcag tcggcgtaac ccagcaccca ctgccgcccg gcataatccc    21480

ggtcttcacg cggggaaatc gtacaaaaat ccccgtccgg ccaggacatg atcccccact    21540

caatccccga ccagtcgcac tggatccggt ccagctctga gggcaccagc cgaaccacat    21600

ccggatggga atgaatgagc atgatgatct caccgcgcgc gcgggcagcg agctggtctt    21660

ccggggagag cgtgaatgtc tcctcgggtt tatcggcaat gttgcggcag ggaataaaga    21720

tttgttgctg gcctgactga acaatcaggc cgcaggcttc tttggggtat tcagcagcga    21780

cgtgctgacg gatagcatcc agcaattttt cacgcatttt tatttcccct gcaggtttgc    21840

agccggaaaa ccgccgaacg gcagcggcgc atccgggccg tgacgatcct gacaatcctg    21900

ccggcggccg ccacaaacat ctttcgacgg gtcatcggtc ggtgtaccgt ctttggtaaa    21960

gtatttcgtg ccgttgtaat cgcatccggt cccgcttcgg taccagcccc gcatacacca    22020

ggtgcagaca ggcgtaatct gccgtgtcgg cagctgcagg ctctgaatat cgaaaggaga    22080

acacagctcg aaatcaacct gtacccgcgt ctctgcggtt ttagcattga cgtaaaagag    22140

ctgtaagcgc tcatcggccg ggctggcacc cggattaccg tttttccagt tggcggcatc    22200

gagatacttc gaaagcgtgg tatggatttt gaccttagcc ctgaccatat cgtcatattc    22260

aagacacagc gcggtgacat agtttccgac gttcccgacg gacagcgtgg gcgttggctg    22320

ggaacctgta ctcgataact ccatcccctt aagttcgtag ggatggggat cgtactggtt    22380

tccctgccag ataatggcgg gcagattttc tgcggcgaag gctgcccacc cctcttcctg    22440

aatattgtgc gcatgaaaac gcagcacctg atccataccg aattcagtgc cgtcgatctc    22500

aatcagctga ataacgctgc cgggctcaag ctgttgtatg tctgccgtaa aactcatact    22560

ccccccataa aaaaaagccg cccggaggca gctttcagtg tttttcgaga aaatcagggc    22620

gcgaacgcct gttcaaaagt gaaggccaca gtggcttttt tcccggtagg gaaagaaacg    22680

ctgaacgaat cggccttcat tctgaacagc tttttttcac cccatggagt ggtccaccag    22740

aacgatttag taacgtgaga catcaggaaa gcgcgcagcg cagccgcctc ctgtctggtg    22800

cccgtccagt ccaggttcca cgtttcctgt ttgtcgttga tccccatccc cgctatctgt    22860

ttgtagccat ccccgaactg ggcctgcagc gttcgggctg tttcagtgcc ctgcgctgtt    22920

tttcgcgtgc gccaggtaaa cgtgtccgtc actgtgtcct cctcgaataa agcacgccgc    22980

ccgcggacat ttcttttttc agtcgctcgg tgattgtctg ctgaacaatc gcctgcagct    23040

gtttcgccgt ccccgtggcg ttcgcctgat ttatgcttcc gtcactcccc tgctggctga    23100

tgctgactgg ggcataaaca ctgatcccgc ccatgccagc accggctgcg ttcccgccgc    23160

cgaccagacc acccgaggca tacccgcgca tcaggcgata gagattagcc acgccgatgc    23220

ggctggttga ttctttggtg aagacgaatt ccccgcggtg aacgataccg gctggctcgt    23280

acttgccgcc gtgcccggta aaaccgccca cgtcaaaacc ctgtggccgg tatgacggga    23340

ccgcgaatga ctgaccggca gaggaggttt tcgccccgcc gctaacccag cccattgcac    23400

tctggatggt gtaagccacc agcagctggt tgataacgga cacaatcatt ttaaggatcg    23460

agctggtgaa ttccctgaag ctcgccttcc cggttgtcgt caggctggta agctggcccg    23520

ccaacccgct gaacgtagcc tgagaaatct gctgaacgga gctgaaaacg tttgtcgctg    23580

aatcctgata ttcggcccaa ccctgtttcg caccggccag ccagtttgca cgcagggcat    23640

cttcagcttc gaacgtcgcc ctttgctctt ccagaacctt ttgctgcgcc tgagggttgt    23700

acgaatagct ttcgctgaga cgctgcagcg tagtttgtcg cccggcttcc cgggtggata    23760

acccctcaga ctgagcctgc aggcccgccc tggcggcttt ttgctgctgc tcaaacttca    23820

cggcctgatc ggccagctgg ttgagctttt gctggctggc aaccttatcg cccaggtcgg    23880

ccagctgccg cttgtactcg agcgtttctt ctttgtgcgc cagcagggat ttttcctgcg    23940

ccgtaagctg acgacgccca gcggcctcct gcagaacggt gaactgattt tcagtttgcc    24000

agagatcctg acgctgttta cttatgacgt cgttcacgct ggtatgctgc tcaagcgttt    24060

taagctgggc ctgaagggtg agaagttcgg cctgcgcctt ttcctcggct ttgtccccgg    24120

cgggcgttga gtagcttttg cctttcggtg tttttggatc cttccactgc ttttcaatcc    24180

cggcgcgggc cgcggcaatg tccttttcag tccacagcgt ggcgacaccg tctttcgcat    24240

cctggcggtt tttctcaata agctgactga gctttttctc tgctgaagcc cgcttttctg    24300

ccgccgtcgc gccggactcc accagctggt taaactgctg ctggctgcgg attgcctgag    24360

cctgctggtc cgttcgcatt ttttcccgcg cggctgccag cccttcctgg gcgtattgct    24420

gatcggcaag atcgtaagcc tgctttttca gctccacctg ctggcgcgcg tttctcagcc    24480

tttccgcatc cgctttctgc agaacgttgt taccggcata atccgggtcg accttaagat    24540

tgctggacag cgcgcggtac tctttctctg ctgcctgcca ctcagcaaaa gagtcctggc    24600

gcttcatcgc ggtgtcagga ttacgcccga cgcccagcat cgcatcccac gcaccggagg    24660

cggcattctt cacccagttc caggcttttt cgagggatcc gagattatcc tcgaccgcac    24720

cggcgcgctg aatgaccgcg tcggaatatg cccgcatggc cagctcggca gccttctgag    24780

aatcccccag cgcctgagca gaagctatct gttcatactg ggtggctgtc agaaaatgaa    24840

gggaatcgtt gagcgtcgcg accgcgttaa ccggatcatc cttcaggcgt ttaaactgat    24900

ttatggtttc gtcaacggcc tgcccggtag cctgctgcag cctggcggca acattgctga    24960

ccatgctgac gtcattaccg ctgaacgcgc cgctgccaac gacctgcgcc agcacgcctg    25020

cagcggcatg ctgagtgatg ccattacctg ccagcgagcg cgccagcgcc tgcagctgcc    25080

ctgacgtttt ccccgcgtag ttcccggtca ggatcagctg cctgttaaat tcctcagact    25140

ctttgctgcc gtcgtaccag gccttaccca acccgaatac cgccgcggca atccctccga    25200

ccatgctggc gatcccaaga ccgcgcagtg acagaagctg gtctatccac cctgcccggt    25260

tagccagcgt gatcccggag ccgcgcagcg cgccgaagtt accgcgcatg acctcgccga    25320

tcagtattcc cagttcctgc cgggcggcgg cactttgcag ccccagaccg tgcgtggcga    25380

ctttggcagc ttcgagcttg cggatataga cttcagccgc atcgctggca ccgacctgcg    25440

ccgccttcat gcgcagtagc tcggtaccgg agagcttttg ctctgcaacc tgttgcttca    25500

gctggctgag gaatcgcgtg cgcgctgcgg ccgatttttc ctccacgatc tgcagttctt    25560

tttgacgggc cgtggtgcgg gaaataaggg cgagataatc ctgctgggtt atgttgccct    25620

gtgccctcgc tgcgcgaaag cgcgcctgca cgttcgcaag cgactgtgtt tcaccattga    25680

gctggcgtac gccgtcgatc tggcggaaaa atgatgccgc aagttcatcc tgtcgacggg    25740

caagcgcagc ggcctgcccg tcattctcac gcatgcgctg attaagctcg gtcacgcggc    25800

ggtgagtttc atcaacggac tttgaaacgt tctgccagtc tttggtaagc ccttccgttg    25860

cggccgactg gcgggatttc atatctgcgg cagccgccgc gccagcgtca cccacggttt    25920

taaacgcagc cgcctgccgc tctgaagcgc gctgcattcg cgtctggact ttttcagagt    25980

cctcagccat cccggttagc tggcccttta tgcgggcaac ctgctcacta aacgtggcgc    26040

tgtcgacgtc aaggttgatg accagatcgc taatctgctg ggccatatcg gatacctcct    26100

gttatcccct cagctgcggc catcagcgca tcatcatccg gctcgtcatc gctgatgacg    26160

ataccggaag gagaaagcag gctgaaatgt gcgggggtaa gttccgggtc gcggaagaaa    26220

agagtggaga tggaataaag cagctctgag aaatgcgcat cgagctgagc gtcctgaaaa    26280

taatgctccc ggtagaactg gtgccagtcg cccagctcag tggaagtcat tccagccagc    26340

atggcgcgcc agtcgggtcg cccgaactcg cgcgccagat tcaggacaaa cttcagctcg    26400

ctggcaaggg cttttccgcc gcaacgggtt ctgcgctttc ggcctccgct ggggcatccg    26460

gatcggcagc tttgtcatcc tcaaccggaa cgagcatgcc ggagagcagc tttatttcca    26520

tttctgcttt accgatcgcc tccggcggcc agccgctaag cacctgctgg taaagcgtct    26580

ccacatccgt gccagccgga tcgttatgcc acaaagacat cgcaatcaaa cgcgcaccgc    26640

agcgaatatt tgagccaatc agcctggccg tcatttcctg atcgctgatg ccgtcgctgt    26700

cagcgctgac ggccttttcc tctgcggcca taaacgtgat gtactcaata cgctgaagcg    26760

ccgacagctc gaagatggtc agtgattctt tttgccaggt gaacttctct tttttcagaa    26820

acatgcgtcc ttccttacgc tgcagttacg gtaactttgc agaccgcaac gaaattaccg    26880

tcgctggtca taacaataac gtcagcggtg cctgccgcca cgccggtgac ggtgatcgca    26940

ttaccgctaa cggtgaccgt tgcttttgcc ccgtctgagg ttgccacacg gaacgaggta    27000

tctgaggcac tggctgggtt aaccgtcaca ttgagcgttg tggttgcgcc gacggccacg    27060

cttgccgtgg ctttatcgag cgtaacgcct gtcacgggga tattcggggt cccgctttct    27120

tctgccagtt ccggcttgcc ggtattggta attttcgctg tacgggttat gacctctttt    27180

gccggaatgg ctttacccag gctgctgcac cagccgcgga aaacgtcgac ggtaccgttc    27240

gggtatttga ttttgtaata gcgtactgag ccatcaataa accatgcgac aaggtctttt    27300

tgcccttctt cgcccggctt ccaggcgagg gtgaacgagg tatcgccagc agattttgcc    27360

ccctgggccg tcgcgttcca gtcggcatcc tcgtcgtcga ggtaagtgtc gtcatacgat    27420

tcggcggtca tttcgcccgg cgtcagctct ttaattttcg ccaggcggtt ccagtcgata    27480

tccgagagtg ggttagcgaa agcgttgccc gttccggtgt aaagccagag ggtggtaccg    27540

gcacctttca caggggccag cgggtttgga gtaggcataa gtacctctta aattgaatag    27600

gtgattaagt acgtgaaatc gactgaaccc caggtggcca tttcatcatc ccgctgatag    27660

tcataaccct gcggggtgaa cgtctcgacc agttcggtca gacctgggat gaaggccatt    27720

gccggataca ctttctcttc catccaggaa tcaagcgcgc tgtcggggct ggaggcttta    27780

agaaatacct cgatgtgaac aaccgcctgc cacgaatctt cgtcaagcga atcgccggtg    27840

tactccgcgt cagaaaggta tacagccacg gcagggagat cctgctcttc aagaaaaaca    27900

gggcgcccgt caaaccaggt gaccgtgtcg gtgatctcgg ctttcagttt ggccagaatg    27960

gctgcacgaa ttgcgctgtg tctgttcatc gcttcaggtg gatcctcagt tggtttttca    28020

gggctgcgga aagttctttg ggcatatcgc tttcaataag gcgctttgaa atagcggtga    28080

aggccacggt gagcggtgtc tcaagaggaa ctttgaccac atcaatcgga taacgggcct    28140

gacctacgcg ccgcatgacc tgccagcgcc cgttcgcaag ctgttggata aaagcgttac    28200

gaaaggtata gggcccgatt ttaaggacgc tgcccgctcc gtttctggcc ccttttttac    28260

gcgagagcct gacgcgcgcc gtgccgagct ttatcgcagg aagattaccg cggttgattt    28320

ttatcgacgc gaccgggcga tcgtgacggg ccttgcgcag acgggaacgc tggcggacca    28380

gacgaaccgg aagccccttt ttccggttat catcaactgt tgcttctttc gctacagctt    28440

tgctcccctg gcttatcgtt cttctggcca ccctgttaag tgcttttgcg gttgcctcag    28500

gaacgattaa ccggctgagg ctgttcaggt tctgaatagc cctttccagt cctttcacag    28560

acatagcgcc tcctcattcg agatggatgc ggggttttcc gttgaacatg tcatagcggg    28620

taacgatcag gttcttaccg tcgtagtcga cgctgtcgtt tcggcgtggc tggtaaagct    28680

cagagaaaac caccagcgaa gtacctgttc ccgacaatgg ccccatttcc tcgagttgct    28740

cggcgggaac aacgtcatag ctgctgccat tgatgatcgc tgtctttccc atctttttta    28800

tagtggccgc gtccatgcgc gccgccatcc ggtcaaagga gttaggcatt gatcttaact    28860

tcaacaacgg tggtgtttgc ccctgcatct tcccaggcga tgcccgcggc aacggcgtcc    28920

gtttcttcga tcgtgatttt gccgtccttc agatacacct gcgccccggc agtaaccgca    28980

tctgcggata cttttggcag gaggaaaaca ccctcagtaa aaccgtcccc ggtatcgcca    29040

gccgggatat cggtaattgc caccgcgata agttttccaa caacaaccgg gtcgccgctg    29100

tgaacatcgg ttgcaccact gtttaccaga gggatcgttt tcccgtcctg cgcatagttc    29160

ttagccataa cttctccatt cagccccttt cgaggctggt ttcaggtata aaaaaagccc    29220

ttacgggcgt ctgtttgtca ggactgtttt ttactgacca gaggatttgg tcatgccgcg    29280

atagtccagc ggcgccacgc cagcatcaat acgcactttc gtggcgatac catcagtggt    29340

gaagccttcc tgctgatcga tgtatggcgt gtcgacgccg ttgagataag cgacctcaat    29400

ggtgtcggtg cccttcgcgg cagccagata ccaggctttc gcatcagctt catccagacg    29460

tggttcggca atgacttctg caaagttctg gatagggtta acgatcccgg cattgatgtc    29520

tgcaccttta acactggccg acttgatggt ctgatttgcc agagtttcca gggcgacggg    29580

caccagcatg taggccggac ggatattcag ggttcgctcc ccctccttct gcagacgcat    29640

cagcttgcgc gattcgtcca ggctggccac agaaattgca cccgagctca ggttcttgtg    29700

atcggcatgg aacagcgcct ttccgtctga gagtttcggg tttttggtca gaatggcgta    29760

aaccagatcg ccaatcgttg ctttcgccgc gcgccccatc ttcatcggta cgtcggtaag    29820

ctggttcaga tcgtcgttga tgatcgcctg gcgagttact gagaagattt caccatacgt    29880

ggcaagcgcg atggtttcgc ctttgtcact ggtagtgatg tacttgtact cagccccttc    29940

gcgaacctgt cgcagagaag ggaacccacc cataccgaca cgatgcgccg ttttgaagtc    30000

cgacagctgg ccttttttgg tccactgctc gaaggtttcc tgcgcctcgt cccagccctg    30060

aatcagcgct ttgttcgcaa catcaagcag aatgttgcca aagtcagagg tgctgtgggt    30120

cagcgccagg ccaaccatct gcatcgggtt gtagctggcc acgccgatac ctttttctgt    30180

cagggccata cgcgcatact cgcgcagcgt cataccgtta taaacgttat cccgctcctg    30240

accttcgaac ccggcacgcg ccatcagtgc ctggcgaata ccatccgcga cgaagttacc    30300

gttgcccgca tgaatatgcg gctgagtggt tttattggac ggcgtggccg ttttaccgag    30360

ttctgccagc agcaaatctt tcgccttatc gacggagcaa tcagggtcgg ccacacactg    30420

attctgcagt tccatgtgct tattaccgaa catggcaaag agatcgccga tagcgttaac    30480

acgggttttc tgctcagcca acacctgcgc gcggatcgca ttttcatccg gtgccgggtc    30540

tgtttttgcc tgcggtgcct gaggctgggt aataaccggg tcacgctggg tagtgttgcg    30600

cggcggggtg atcatgttgc gaatgctttt tggcattttt tcaaattcct caatacgttt    30660

tgaatgaata caggccatag cctgaaggga tggtgtcacc tggtcggcaa aacccagttc    30720

aaggcactcg ctgccgttca tccaggtttc gtcctccagc attaccgcaa tttcttcggt    30780

ggattttccg gttttctgtg cataagccgg gataagaacg gattcaacct tgtcgagaag    30840

atccgcatag tcgcgcatat cgctcgcgtc accaccagca aacccccagg gcttatggat    30900

catcatcatc gtgttttcag gcatgatgac cggattgcct accatcgcaa tcaccgaggc    30960

catggaggcc gccagaccgt cgatatgtac ggtaatcgcc gcgccgtggt gcttcagcgc    31020

gttataaata gcaattccgt cgaagacatc accaccgggc gagttgatat aaaggttgat    31080

gtgggtgacg tccccaagtg cccggagatc attgacgaac tgtttcgccg ttacgcccca    31140

gtacccgatt tcgtcataaa taaaaatgtc ggcctcactg ttattgctgg cctgcatgcg    31200

gaaccacgaa ttactttttg cgctggcttt cggacggtgg cgcgcccggt tctttggctt    31260

cggcactggt gcctccttta tcattggcgg ggtcggtgtc aaacaccagg ccctgttcac    31320

ggttctcgtc aacctcagct ttacggcgtg acttaacatc atccgggttg cgaccgctgg    31380

cacgtatcca gtcggattca gtagcagcac cgccgcggat ctgcgttttc caggcattcg    31440

cttctttaac gggatcaatc cacggcataa cgggccccga ataaaccgcg ttataaagcg    31500

agtccatatc aatgcctctc ggcagcttga tttctccggc agcaatagcc atcttgagcc    31560

aggctcggta catgggccgg gtcactgaac cgatgaacca gtcctgaaga atcagatagc    31620

cgtcggttga ctcgacaagc tcctgccgct gggcactgta cgttccgttg tagtttctgg    31680

atgtgctgga aaagctgagg cgactgccgg cggacacggc acgcagctgt ccgttacgaa    31740

aagattcgag gttagggttc gggcgatcgg atttaatcat cccgatttct tccccggcct    31800

gcagttcgtc atagagcata ccgggctgaa tcatcagctc gcggtcatcg ctgcttgaat    31860

cagaatcgaa gctctgtccg tcgccttttt tgatatacat gccgagtgcc gcagcaattc    31920

tggcagcagt aagctccgag tcctcgtatt ctttcagcgc gctcagacgc atcagaacac    31980

cagacaaaag agacgttccg cgggtctggt gcaggcgtcg ggtgaatttg agatgcagca    32040

tgttctctgc atctatctct ttggtatcaa actgacgccc ggatactggc aggcttttat    32100

agacctgata ttttttcggg cgtccccagt tatcgacaaa aacgccctga ttgagctggg    32160

tggcagcatc gctgttcatc ggcacaaagt ccggctccag cgcttccagc cagaacggca    32220

cgccagcaac cggctgaaga ccatttccgg taccgcgaac cagctgagca aatacctcac    32280

cgtcccggag ccacgttcgc agcatcagcc gctccagcat tgggcgggta aactgggttg    32340

tgacatctgg ccttacggac cattcgcccc actttcggcg gatatcagtg gccagctttt    32400

tagcgatctt cccgttactc agcatcggat gcggttcaac tatgatgccc ttcgcaccca    32460

ccaccctttc ttccagcttg tcgaaaacgc cgatcaccag atcgtggttg ttatccagcc    32520

agcgcgcctg ctgcctcagc gaaaccgccc ccatctggct gagctgatcg gctgaacgat    32580

tttccttctg ggctttgtgg gtacgcgttt gctttaccgc ctcatacgct ttaataactg    32640

cgcgggcacg caggcgtgag gctttccagc ctggtgaaaa caggccaatc gcatcatcta    32700

aaaaactcat ccaaacctcg ccagcctgta gccgggtcgc ccacggcgtt tgttattgag    32760

cgttgccagt cgtcgctccc attcctgacg gccttttctg atttccgaca ggttttcgag    32820

cgtcatctgc tgcccgttga aagtgattga tttcccctcc agaacagaca gctcggctgc    32880

agcatagcgg tcgatcatgt tttgaatatc tgctggattc acacccaacc tcctgacgaa    32940

gaccacggat tagcctgctc ggttacgggc ttctcacgtt ttggttttgg tttagatttc    33000

ggcgcaggcg gcggggatgg catttcgcca gcttccgtct gcgtgtcctc gatccacgtt    33060

tcccgccgtg cccactcagg agctgacggc catttgattt tttcgtaacc actaaggatg    33120

gcgagcgcgt cggcataaac gagcaggtca aatgcttcgt ttgcgccccg gccgggctta    33180

ctccatttcc cttcattcga gcgttcctca tacgtcagtt cgtcatagaa ccagctgccc    33240

agccaggcgg ggaaatgcac atagccaggg ccgggtgaat cacgccacag cgcattattc    33300

acccggtctt taagggcatc ggtctggaga agataaagag gcacatcacc agtcgcctgt    33360

gcgcggcgcg ttgatctgcc cgtgttgtcg ggaaacgttc gctggataag tttgctgcgc    33420

ctgacgctgt cccctttgaa gagatagata cgcttaccca gcccctcacg gcgacatctg    33480

cgccagaact tgtaggcatt atccgtcacg ccatcttcgc cccctgagtc cacggccatc    33540

gacatcagcc gcatgccctt tgatgggtca gctgcgagcg gccacgtttt atcaaagacg    33600

tcagtgagta aaagatccca gtcctccgga tagctcgccg gatccacctg aatgctttca    33660

ccgttgccgt cgcagcgcag cgaatgccgg atgttgtaac ggtcaactat ccagcgctca    33720

cccatacttc cataacccgt aatctgcaca acaaagcgcc ggttgcgccc ggcctgcacg    33780

tccacggtcg cagtgagaaa ctgcacgccg ttcggtaccg aacgttttgg gacgtcttcg    33840

gcacgctgct cgagcaattc acttttacgc tgctccatgc tggctcgcgg caaatagggc    33900

ctgccgaaat cggtgttgat caccgtcttc agggtttctt cgctgcgcgt ggattcatat    33960

tcctgctcgg cggtcagaaa cttataaata agctgcgccc aggtctggta agcagctgcc    34020

ggaccttcca tccagaagga ggcaatacgg gaacgacggc catcaccgct aaccaggcct    34080

ttcctgtcga tggtttgccc gtcccggagc cagacacatt tcatgttaag cgcacgcttc    34140

atgtccggtg tgatcctgcc tttacaggca gggcactgaa gaaacgccgc ttcgctggca    34200

agcacaggat cgctgctgtc gcggtatccg gtcatattgt ccatttccgg ctggaaatat    34260

tcgccgcaat gcgggcatgg ccagtaaaga cgacggcggt caccacggtt atagagcgat    34320

aaaattccgg tggtcggagg ggcttcatgg ggcgtggagc gccgccattt tgtgtctctg    34380

atatccctcc cgggcgagct ctcaaccagc gtcatcccgg aggacatgaa tgtcgtggtt    34440

cgtttcgatg ccagtgaaaa agcatccccc tccccgtcga tatcttccgg aaagcggtca    34500

taatccgtca gcgccacact tttatagtcc gaggacgaca tgatattgac ggatggccag    34560

cccagcttca gatagttacc ggcgcggaat gtacggtcgt agacgttgtt atcgttacgt    34620

cttgggctta gccgggtttt aacttcaggg ctacagcgaa aagtacggtc caggcgtttt    34680

ttggaatgct cgcgcgcttt ttcctcagat acctgaatta caagcatatc tgccggatcg    34740

cagacaatgt tataaacgat ccagccgtca atcagcccga tggttttacc cgttcgcgct    34800

gggcccacaa acacaaccgc atcgtattca cgcgatgcca gacagttcat cggctcaatc    34860

acatagggtg ccagatccgg atcccacgga actgagtttc ccgcccccat tggcacgcgc    34920

atataagtac tgaccgcatc ggccaccggc atacgacgcg gggctcgtaa aataccggaa    34980

acatcgcggc ggatgtccct ggcggatgcc cgctttgcca tcagtcctcc tcaggctgct    35040

cctcctcttt tccagcgtcc tgcaccttct ccgccatctg gtcgcgcaga tcatcgataa    35100

cgctttgcac acgaactacc gcagcaggcg ttaaagcaca gtcgcgctcg agcacatccg    35160

ggagggtttc aagtaccatg acgacggctt tcgccatcaa tgagaattct cgcgccactt    35220

catctgcggg tattaactgc cccgtatcct gttcgaactt cagcctctcg ttctctgctt    35280

tccagtggga cagcctgtca gaagggggca tatcgtcgat gttggccgaa acggtaggga    35340

tcatcagttc ggtcagaatg tcggtcacca gatagagctt taacttgcta ttgctgcctg    35400

gagcaggttc aacatttttc agtctcgcgg caaccgtctg acggtgtacg ccggttatcc    35460

ctgccagctg gttgatattg agttttaaag tggcaatttc ctggtccatg atggtgaaca    35520

ctttttgaac gattcgacat gttgcgaaaa tggcctctaa ttaaatcaaa gacctgcgca    35580

catgatgatg atgaccctgg atccgaaaaa ctagccgttt cccgcgagca cgccgccccg    35640

tggcagggtc cccctccggg agtacctttt gataataatt atcaattgca cactatcgac    35700

ggcactgctg ccagataaca ccaccgggga aacattccat catgatggcc gtgcggacat    35760

aggaagccag ttcatccatc gctttcttgt ctgctgccat ttgctttgtg acatccagcg    35820

ccgcacattc agcagcgttt ttcagcgcgt tttcgatcaa cgtttcaatg ttggtatcaa    35880

caccaggttt aactttgaac ttatcggcac tgacggttac cttgttctgc gctggctcat    35940

cacgctggat accaaggctg atgttgtaga tattggtcac cggctgaggt gtttcgattg    36000

ccgctgcgtg gatagcacca tttgcgatag cggcgtcctt gatgaatgac actccattgc    36060

gaataagttc gaaggagacg gtgtcacgaa tgcgctggtc cagctcgtcg attgcctttt    36120

gtgcagcaga ggtatcaatc tcaacgccaa gcgtcatcga agcgcaatat tgctgctcac    36180

caaaacgcgt attgaccagg tgttcaacgg caaatttctg cccttctgat gtcagaaagg    36240

taaagtgatt ttctttctgg tattcagttg ctgtgtgtct ggtttcagca aaaccaagct    36300

cgcgcaattc ggctgtgcca gatttagaag gcagatcacc agacagcaac gcgccacgga    36360

aaaacagcgc ataaagcact tcattagcag cgccagatag cgtaatgatt ttgttactca    36420

tggaatattt ccttttaggc gtgagcctgt cgcacggcaa tgccgcccga gaggtaaacg    36480

caacctaacg gcatcaccca ggctcactac tgaaagactc tctttgatgt gcgcgtgcga    36540

tgcgcgtaga agactgattt atcaacctgt ctttatatca ggattcatta cctgactatt    36600

tgtgggtaaa gttcgtagtg cgctgatcgt gcaaaatgat tttagttggg aacagttcgc    36660

aactctgtcc cataaaaatc agcatattcc catctatccc atatccagcg cattgaccat    36720

cgggatactg aagggagatt ccatcatctc ttagaaagat caccatctct tttgtttcaa    36780

tttgcatata gctacctgga ggatttatga atgcaaggat tttcatggac tattaccatg    36840

agattgattt tccatcttta ttcgcgagag cagtggaaag cgatgacgat gtgggtacta    36900

cattgcgcat tcacctactt tgtgagcgca tggtcgaagc atggatatgc gcatgctgtg    36960

actgccaaga tctctttgga agagataaaa acaaactttt aatcgaatgt aatactaaaa    37020

tatccatggc gggaaacctg ggaatccccc cggaacttat gaaatcactt aaaaccatca    37080

actcaatgcg taatgacctt gcacacaatc catcaataca aagcattgct gattcaagga    37140

tccagagcct gaaggatact ctgactgaat actttaaaca gcatccaacg gaacccagca    37200

tggaagaatc aaaactgggt atttttaacg ccgagaatca attaaccgaa gaagtttcct    37260

tagatagtga cagttcaaaa aacagactta agttaatctt gctgttcagc aagttaatgc    37320

aggcgttaat gcaattagtt gcagctaatc ataatgggcg ctgggataac caatttagcc    37380

aattcgttta ccatgtgacc atgaacgcaa caaagagata aatccaagcc cgttttgtac    37440

gggctgttgc attatcacag gcactcagtg aatgcctgct gtaatgccgc tagtcgtcga    37500

gttgcaacac accgtgatcc agtgattctg aataggcgat aagtccggta taaccgggga    37560

taatctcacc attatcagct tcaaattcag gaattgtgcc ggtggtgatg gtgtattgag    37620

gctggccatc ttccttcgcg aaggctgcca ggtcttcaat ctgcttagct gtaagaacta    37680

ctgtcatgct cattcctcag ttgtaaaaaa gccccgcgag tgcgaggcga tttgattgaa    37740

ttctcggctc ttatctcagc gcagcccctt actgcgtgcc ggttgctcgg tgatgagcat    37800

cagcgatgag acattaaagc cgaccgaagg ccagcggcgt tcctcatgtt gccgacagag    37860

ccatatcgac aagaggacga aaactagcag catgaatcgc ctattggtta ttcgacagtc    37920

gcactgattc gtaaatccgc tcacacgtca ttcctgcccg gtagctttcg tcagatcgtc    37980

cagcataata tcgagctgct tctgcaaggc ttccgagcat gtcggcaagc attgctgcgt    38040

tggctccggc tgttttgctt ctgacggaag tggcgagatc tgcggtgtgc tttgcggcgt    38100

ccatgtgggt agcgagtttt gttgcttcgg cgcgcagctg cttaacagtg gtagccaggc    38160

cagcagaagt aacggcagcg ctcgctgctt gagcttgagc atctttaacg gcctcatccc    38220

gggcgattgt tcgcccttgt tcaatcatac gagctgcggt ctgtgcattc gcttcctgtg    38280

aagattccgc gctatcccgg tcagcccact ttattttcca gctgcggttc gtccactcac    38340

tgccagcgag aaacgaacct accaacgcaa caatcacaat gatgcagatg ccacccggct    38400

tcactggtct atcccccagc acgtcagtgc gctttcctgg tcccgccgtt ctacctgccc    38460

ataacatcca tccttctggc ccttggtcag gcggcaatcg cggccaccgt ctttaatcca    38520

ccagcggata gcttcacagg ctcctttcgt atcgccagca ttaattcgct tatagaacgt    38580

agacgggaaa cattttccgg ggccgatgtt atatgggcag aaagaagcga tacccgcttt    38640

ctgtggttcg gtcagtggta ctttgatatt tcggtcaacc cacgccagcg ccttgtcgcg    38700

ttcaatggcg tttacctggg cgcatttctc agctgacagc ttcatgccct gtactactgg    38760

cttgccatca accattgttg caccacggca aatggtccag agtccgccgc cgtcgcgata    38820

tgctgtcaag ctgttaccct ctttctcatc cagaaactga tcgagaatca cgggtgcgga    38880

agccccggca agaatcaaac caacgaccgc tgcgctcaat ttattcttca gctttagaga    38940

catagccatt gcgccgatcc tcccgttctt tccagcggaa ataccagttc actgcacagg    39000

tgattaccgt gcatgcgata ccgacaataa ttgcccagtc gctcaggctt aaccctgcaa    39060

ttctgtcggc caacatccag gacacctctt ttgctgtttt agctgtttcg gcatatgcct    39120

tcgctgatac accgcagccg gcaagcgtgg ttcctgatcc atatgaaagt ctgctgtaaa    39180

tggtgctcat tctggtcata gcctcacctc cgatagttcg gatggcgctg tgtgtgattg    39240

aaggggatca ggcaaccggg ctcttatgtt caagtaaaaa ttaaggatga ttcccggtgc    39300

ctgaagatgg tgatcaccac agcaacgggg gagcgtggtg atcgttatga ttttttcagt    39360

ttttccacct cttcggtggt ctgtataaac ctgtctgcct ccagttctac gccgatcgcc    39420

cgacggccaa gttctattgc agctttcaca gttgaaccag agcccataaa gaaatcggca    39480

acgatatccc ccggtctgct gctggcgcta atgatctgtt tcagcatgtc ggcaggtttt    39540

tcgcatggat gtttgcctgg ataaaactga acaggcttat gtgtccatac gtcggtataa    39600

ggaacaagag cggaaacaga gaagcagcgc cgaaggattt tgtattcctc cagcaattct    39660

gaatacttgc ggtttaatga ctggtaggta gccaccagct ggtggtgagg atgttcaagc    39720

ttttgctgaa tatgtttatc gatggcgatc cgcgtgaaca gttcctgcaa ttttcgatag    39780

tccacttcat tcggtagttg ccattggctt gcaccaaacc agtgtgacgc catgtttttc    39840

tttccggttg cctcagctat ttctttcgag ctgacaccca gtgattcacg ggcattacgg    39900

aagtaatcaa tcagcggcgt cataatgtgc tgctttagct ctgtgctttt cctttcgtaa    39960

acatcctctt tacctgtata cggtccaaga tagtgctcag caaacaaaat ccgttccgta    40020

gatggaaagt acgcacgcag gctttcttta ttacatccat tccagcggcc cgatggtttt    40080

gcccaaatga tgtgattcaa aacgttgaat cgggcgcgca tcataatctc tatatctgag    40140

gccagtcggt gaccgcaaaa caggtagatg ctgccagcag gtttaagaac gcgagcatac    40200

tcagccaggc agctatcaag ccagcgtaag tagtcctcgt cccccttcca ttggttgtcc    40260

cagccgttgg gcttcacttt gaagtacgga ggatccgtaa ctataagatc aatagagtta    40320

tccgggaggg tggcgacgta atgcagacta tcagcgttga ttaactcaac actgtttatt    40380

tttacagtat ttttcataga tcagtaagcg taactctgat aggctcacgt tgcttttgcg    40440

ctaaagcagt gggccttggt tagcttgtga cctgaaagca tgagctgatg gctggccggg    40500

tgcgctaaca cccaccagcc gcccatttcc acagcagaaa acccccatta ctggaggcgt    40560

ttataacatc cgaactggta atcagataac cccgccatca ccagctgcgt aagtatgagc    40620

tggcaacgtt cgtggctgag gtgggtattc tgtgcaatct ccccagccgt tgctggttta    40680

tcgcttaatt cattgaaaac agcctttgcc gtttctgtca tatcttcctg atttagcatg    40740

tcttttacct aaaattagtt gcgtgacata cagataactc tggttggtga taccagcaag    40800

agaagaattt gattctgcaa ccaacaaggc ctttaggcat caggcaggaa tgagatgcaa    40860

taaaaaaacc acccgaaggt ggtcttatat gaatctttaa cgcggactta gcaaatattc    40920

cacatcatcg tactaccgtt atggttttcg ataatttttg cggctgggct agtaccaaaa    40980

gagtgcatat agcaatgatg aatagtaagg accagatcct gcaacgtttg gtcactctct    41040

agctccatga tatttaaacc aatattttga gctttgtcca aatgaatatg tctggcatgt    41100

gcatacgttg cttggtggtt gtttaactca tcacatatac gcttagcctt agcttcagcg    41160

tcagcctgac ctgcgaacat accagtacaa agccatttct ggacaatttc gttcgcccag    41220

agaattgctt tttcacactc gccaatcaac gttggattta gtttttggaa cgtaaattgc    41280

caccattgca gtgcagcagg gttggcaaaa atttccgctt ttgctctctc atactcctca    41340

ataattgcat gagatgataa cccattaaac tgtggatcaa ttggccccaa gttcgactgt    41400

ttacctaaaa cgatctgctc agcacaacaa gcaagcattg tgccacaact cattgaaatc    41460

ataggtacaa tcgctcggat attggttccg aactttgaac gaagataatg accaattgat    41520

tctagagctg cgatatcgcc tccaggagta tggagtaaga tatccaatcc cagactcgta    41580

tctaacccat tgatagcaga cataagacca tttttatcat catctgacat ctggatcaga    41640

tgttgaaacc caggcccccc tttttgaagg aagcctgagt aataagaaat tacatttcgg    41700

ccagtatgtt tcgataaatc acgtaagtac ttgtggcgaa cctcatccgc tggtgtacgt    41760

tgagcgatag tacccatctc acccaatacg tctatccaat ttggcatgtt atcaatttat    41820

cagtatgagt acagttggtg agattgctga ccgttctgct cagtagtatt tggtgttact    41880

gtgctgtatg aatagagcac accacttctc acattcagat cgttttgctg agcgagaaca    41940

cgcatagcaa aatgctgtac ggattcgcct ttttgaaact cttggggttg tatgcccatt    42000

ttttcgtaaa attcagcagc gctcatgata tgtccctcgt ttttttctac atctatgcaa    42060

ttccaggagc catcaacaca agatgtagta gttagcagtc gtcaaataca cgaaaagcct    42120

caagatgagg cttaaaaaga ttctttttga taaagattta gccaaactat agcggtcaaa    42180

atgcagattt gacaagtata aaaagcactt aaagcctata aataggcagt ttttgagaat    42240

taaagcatct ttaatgaggt tgaacaaaat gcagtcttga cgctgaacag gactttactg    42300

gaacgtagag ctaaatggtt cgatttcatg aaccagttac aaaaaaaccc gctcatcggc    42360

gggtttataa aactttggca acatatcaaa tatgcttcaa atatggctta ttttgttgca    42420

ttttgcaagc gtgtttgaag gagatggtga aatttacttc acatttctgc cactttgagg    42480

gcttcttctt cctcatagta ttcaagagcc atggccaacg cagattcatc aagctgggta    42540

aaagcggcct ttaacccagc ccagtgccct gaatagacac gcaaccatgt cgaacggtca    42600

acgctaacca tgcgggccaa cgctgcacca gcatagtctt tataggtttc attatttctg    42660

gttgcggcaa tttcctgccc tgccagccat accaggccta tcagtttctt tactacgcgc    42720

tcctgaaggg agttatcacc caggcatttc tgataagttt tccagacgta ttcacacatc    42780

atcacctggt gcttatagct aaggtcaaaa ccgtagcagt accgcaacca ggcctgctgg    42840

tatccactaa gcgcggacac tgccctacgc cacggcgcgg actcaaattc cgcatctttt    42900

atcggcggca ttggcctgcg gcggctgcgt gtttccagca catacagtgg cgcggaaagt    42960

gagttaacaa agcgtggccc cttctctcct tcgagttcga cgagatgaat tccacggcga    43020

ggggtggcat ttttgtctgc tggtgggtgt tcactgaaag cctcaagctg cccttttgtt    43080

cccccagaca ggtcaggtag cgcgcggcgc aattctattc ttacaaaatt caggtcttgt    43140

tgattcatgc ttctttgcgc tccatacact taagctttcg caattacgcc gatcgccagc    43200

gcccgatcca taaaacgcag tagcagctca agctgcgtac catgcttctg ctcgaatgcc    43260

ggtacatcgg cgtgtaactc gtcgtggcac tctctgcaca gagggatcac gaagagatca    43320

tgggcttttg ttgctgtccc ccccataccg tgccctacga tatggtgcgg atcatctgct    43380

ggccgtcggc aacactcaca gggttgtgtt ttaacccagc gggtgtacgt ctcatttatc    43440

cagcggcgtc gctttggcct gagcatgaaa gattctggag actccggatc aacagagagc    43500

gtgaggatct tcttcgcctt ctcctgcacg aggctggttg cagaagcgga aggcacaatg    43560

tcgctttccc tcatgaccga gcggatctta tcatccggaa ggcgtagccc cttgtgcgca    43620

acgctttccg gaataacatc agccaggtcg tttctgacca tccaccagca cagttccgga    43680

agcgtcagga tatgcgactc gggaaaacca gaatcacgcc gaatgacttc cagaatccag    43740

gataccaggt ttcctgccgc tatacctgca agctgttcgg tatgctgccc cgacaaagtg    43800

tgatcgcaat gccagcacag gcgaatactt cctggtgggt gccgcattgt tgtgaagttc    43860

ttgtcgtgcc acgatgaatg tggccactgg cattcaaacc gattactcaa ccattgctca    43920

agggaaggaa gcccaccagc acgctgaata acccgatcat tctcgaagac ctgccgcatt    43980

accggatcat cagccagcgg ctgaatggcg gcgggaacag ctcctgtact gaatgacgcc    44040

atttcttctg gttcaggctc aagcagaacg cgaccgcgca taaagaggtg catcagttcc    44100

gcgccgggac gaaacaacac aatccccata cgatgggcga tctcgggggt aagcagagct    44160

ctcacgcgac ctgccccctg gcaatgtgtt ctgcccacag tccaccaatc cagcgcacgc    44220

ctttcgccgt gaaacgtgcc tggctgaatg catgatttga ggttacggat gtgccggttt    44280

tcacttcaaa acggcccgca tcaatatgct gatgccgtgg ggtcatcgtt ccgccaagac    44340

gatacatgat gtcgttctca aggaggaata accgcagatc gggctctttg gccttaagca    44400

gttttgccac ctggcggaat gacattgacc cactggctgt acagtaccga tcaacaaacg    44460

ctaccttcgg cgccgcggca gccagttcgt tagtcaactg ctgtttttgt tctgcaaggt    44520

cagctgcaag acgtagggct tcagagaatg attgaggaat cgtctgctgc tgtgcctgct    44580

caagctcctg ccagcgatca accagacgcg cggtaaactc cggcgacagc tgcgcgacaa    44640

cgatataact gtcccgcttc cctatcagat aaaccgatac cgactgattg aggtgatttt    44700

taacttcccc cattgggggg agttcaataa caccgcgctc tgccaggcgt tcaatggacc    44760

gtttaacatg gtcatgtctt gattccacca gctcagcaat atcgctgctg gacatggtta    44820

acgctgttgt tgctaactgg ctcatacttt tctccatatc aggcggctgc acccgccggt    44880

tcatatctgc tgattgttat ctctacccga cctttcggca caacgggtcc ccattccacc    44940

agcatgcgct taatctggct gtcgtcttcc cagacacccg catgcgtcag cgcgtcaaac    45000

agggctttgt tgtaattatc gatatcccgg cggcgcgcat ccggcgggta cagagtgatt    45060

tctaccgctg ccagttcagt cgatggcttc gggagacgtc gtaattgctc aatgatcgcc    45120

acgcaggcag cgctctggta tttacggcca gcggcgctaa tgaggtgacg accggccagc    45180

ggccccttgt taggggcgcg ccagtaagtg ttcacgctcg gaggaaaagg caggatcagt    45240

ttcacgcggc ctctccccgc atattgcgaa caagttcaga agcagcagta atgatttcgc    45300

tggtggcagt ccgctccagc cagagttgat tgatattggc tttcagcttg tgttgcagtg    45360

actcatccag catgtcagca ccatccacct ggtcgaatac aattctaacc tccagcggcc    45420

agatacggga ctcgggaagc ggatccgata ctggtttagc tttctcacga atgtgcatgc    45480

ggatctggcg aatattggac caactggaaa catccaggct tcccatggct gcaatgaagt    45540

cagtgctgtt catgccatat tcaccggatg cttcaagggc aacagtgcga atacgttccg    45600

acatatccag gcgcacagca gcgtcatcga attcaatcga caacagccac tcatccacac    45660

cgaacaaaat actctcacga ataagcagct tcgctttgtc gatcgttaaa ggtgatacct    45720

gagtgaattc cggtgcttcg acagaatccg ccgcccaggt atgcccaaac ttcgattcac    45780

tgaatgtgta ttcttcttta tcgccaaacg cagctctaac gcatgcccac gcctcgacac    45840

cgctgatagc aaaaatatct ttctgggtga gtggcaactc tgcttctggc ttatcagctg    45900

caggaggtgt ggcagttaca ggttgagact tgctggcagc aaattgtgcc aaagccataa    45960

acgcccgccc ttttgcctcc agttctgtgc ggttgatata gctgaaccgc tcgccacgcc    46020

atgacttatc gaatacagct atggcaccgg caaaaaacgc gctggtgggt ttctgttttt    46080

cgtcagcagg tacaaaccac acaggcagat cgaacccaat gcgcccgcga atgaatacaa    46140

tgtgatcggc atcttccggc caccacgttt cactcggcgc ggcttttatc aggaatacat    46200

agcgaccgcc cttctcgcgc tgggctgctg cgtagttcat gatgtgcgtc atgccggtga    46260

tcgcctgctt ctcgtggtac tgcgaacggc tatacggtgg gttgccatag ccagcgccac    46320

ccagttcagc cagacgttca gaccagtcct gcgtcagcgc gttatcttcg gcggtgtacc    46380

atgccgggca tttcgcgttg tcgtcgtcag caaacaaatc cagaactaat ggaccaaata    46440

gcgcgttgat cccccaaaaa agcagatccg gtgtccgcca ctgatcgcca acctctttca    46500

attcgtgagc tggtttgcta cgcagtgccg ccagcgcctg gcaatattta ttggtcatca    46560

tgaacggaac cccgaatttt ctggcagtga gtaatcaaca ctctggaagt ttgcgcggct    46620

ggctgagtta gtctcccatt tgccgttaac gcgttcaggc cggccagcac tggaccattt    46680

ggtcgcgctt tgcaggtaac cagggaagtt ttttggaatg aacagagttg ccgggcggag    46740

gtattgcgcc tgctcgctat cacgccaatc ggcatttttg taatccacta ccaagcacag    46800

gtcatcaaca gtgaattgtt cccgaagacg ggcgcgaata ttctccagcg acgtgctgca    46860

tacctggtag cgtgagccag tagtctgatt caggtaagac aaaacctgtc tggcctgatc    46920

agtaatcaca acctcagggt cgggttgcgc cgcaaccgga caagagggtt ttgaagttac    46980

ttgtggttct tgttttgatt ttactgacgg atccccacca gattctgacg ggtcaaaacc    47040

gccttttttg ctggatttcg acgcctcaaa ttttgacggg tcggattttg atgcatcaga    47100

ttttgatggg tcagattttg atgcgtcaga ttctgacagg tgagaaaaag cagcctctcg    47160

caacttaacg acgttaagct gatatacgtt cgatgcgtta cggttcccat tacggcgctg    47220

cttacgggaa agccagccat ccttctcaag ctgagcaagg gccgtcctta ccgtactttc    47280

tccagcaccg atttgacgtg cgatcgtgcc aatagacggc cagctaacac cctcatcact    47340

actgaagtcg gccagacgcg ccatgatggc aacgctggat aacttcatgc ctgacgaagc    47400

gcatgcatcc catacgtaac cggttaattt agtgctcatg gtcgtccttt aattctgtaa    47460

atttacgctg gaattgttca agagggctga agcactcatg atcgtaccct tcgcgaaggt    47520

atataacgcg ctgtgtatct ggctcccagc ggacaactct gacgggaact ccgtagtgat    47580

ctctgaaccg ccggttaact tcagccattc ctcgcgcccc ttctcgttca tctgaacaaa    47640

tgcttctacc atcaagtctg ctggctggta gttgcctcca tcagccgcgt tatttatgat    47700

ttccacatag ccgaactggg catctttacc caccagcggc aaacatctga attgcttagc    47760

tggtctgaat cggtttacac tgttcatgcg ttagtttctc cactgatacg acacgccaag    47820

gcgcccggag ctgcacactc gcgggcgtca ccttttctgc ctgttgaaac gaatacgtca    47880

atcgcctgat ctgaaacacc aaccccataa agcgccataa atcccaggaa cccgtgaatc    47940

tggtggcgga gcttcttact gaataattct gaaagcattt tgcgctctga tgaatcaatt    48000

accccatcag ccgctgctgc catcttggca ttagccagct caccagatgc tgctgccgct    48060

ttcatctcaa tgctgtacag ctcaacgtta tccaggctct cagcagttgg aacatccacc    48120

agccatttcc cttttcggtt cgcctggtac tcggccaagt aacaagaacc agacaggtcc    48180

tccatccgtt ccagttctgc caaggtaaag aaccgactgc cacacttctg gtacaggtgg    48240

ttgtggaact ggtcgatagt catccctaaa tcggaagcca tacctaagcg accatgcttg    48300

tgtgccttac acatcaggcg gattgctgta tttatgctgt ctaccatgtt gatttccctc    48360

tggtagttaa taatcaactt aaagttgact attgttgtta gcggaaggta tgccgtcatt    48420

tttgttcgga taaatatcag gtcgtaattg atggggagtt actacccatc cgccccattg    48480

gcagagttga ataactcttt cagaaggtac tcggttcttt gcaatccagt tcgcaacaga    48540

ttgaactgat tggaattcaa accgccttga tacctctgaa atcgacccga tcgccttcac    48600

agctttagct gttacattct tgtgttgaga tgacatgtgt tctcctatga ctaagcctgc    48660

atcaatacta cttatagtag caattattag caacttaaaa tagaaatgac aactatgcct    48720

tgtgcgctta atcttctact tatggtggaa aatgctaaat acaaagactt tgccgaaagg    48780

ctaaacaggt ctctccaaga gcaatctatt ggagttaaag aattgtcaga gttcagtggt    48840

gtctcgtatg agatggcgcg gcgctacact cttggtactg caaagccgag agatgagaag    48900

atgattcgaa ttgcagaaag acttgccgtc tcaccggctt atcttgatta tggtgtgcct    48960

gttaatggtg gcgacgcgcc agccaaaggc acggtcagaa tagagcaatt ggatgttcat    49020

gcttcagccg gttccggata tataaaccaa ccattcccta caatagtgag ctcaatagag    49080

attccagaag agaggatctt cgagttgttt ggtcgtagaa gccttgatgg catcgtcatg    49140

ataaatgttg atggcgatag catgatgccc acgctttgcc caaaggacct gcttttcata    49200

gacagcaagg ttgaacaatt cagcggcgac ggcgtttatg tgttcaattt tgaagacagt    49260

acgttcgtta aacgtttgca gaaggtaaaa gggcgccgac tggcagttct ttcagacaat    49320

gaacattacc cgcccttctt catagaggag catgaaatga atgaactata catattcggc    49380

aagctaatca gatgcttacc tctaaaaatg atagagtttg gctaataatt aattcatcaa    49440

gaaaccggcg aaagccggtt ttttttacgc ctccaattcc tcacctcata acactacact    49500

actaaaaatt tcattttcta ctttttgttg ttgcaattat ctacttaaag tagctatagt    49560

cattgcatcg aaagcgaaca ggcaggacgc ccacgaagta gccgccggtg gcatatgaat    49620

aaccggatga ttcgctgaca gaaaacttag gttgggggta gaggtttaca tgaatcattt    49680

attcacatgc tcattttgcg gagcaaccga actgggagcg ataaagatcg tcgcaaaagg    49740

tggtaaggac gaacctgcca tctgttcgga atgcgtagtc acatgtgtag aaaaaatgat    49800

cctgactaaa aaatcagagg ctgaaaaacc aacctctgat aacgaaataa tatcagtcga    49860

taaaaaacta tttaaagagc ttcttcagct tgtcctcaac cttcctgatt tcggaagtaa    49920

gctggctgct gttgacattg atagtagctc cacatcgaca agtgaaactt ttgttcgact    49980

tgagccaagc gattttcttc ttcgtcttag tgccgcactt agggcatgcg ggtaacgtaa    50040

tttcctggtt atcaaaagcg cccataaaca tccctcttgg ttgtgtgaga acaccaagat    50100

accaccgcgc ctgatgtggt taaaagcagg ctaaagcaat aacaagtaac tccctgttct    50160

ggcggcccgg tgttttcccg tgtatttccg gtaaccgcca gcctttttca gggcacaaca    50220

gaaaagggca tcaccgggcg acgggctcat aacccaatcc acccgggcaa aaagaaagcg    50280

gtctctgcaa gccgccgacc aatgcaggtg cccttctctg ttgtgtatgg agaaactaac    50340

tttttagcgt ctgtgcagat gcgctgagga accgagaatg aataatccgt ttttcaaaaa    50400

tatgttggtg tatcgcatta gtcgcgattt caccatcaac caggaagagc tggaacagca    50460

gcttgaacta tttcgcttca ctccatgcgg tagccaggat atggcaaaaa ccggttgggt    50520

atcaccactt ggtcagctgt cagatcgctt gcatcacact gtcaataatc aagtgttgtt    50580

ggttattcgc cgggaagaaa aaatactgcc atctcctgtc attactgaag aactgcgcaa    50640

gcgtgtgtcg cgtctagaat ccgatcaggg gcgtcgcctc aaaaaaactg agaaagattc    50700

gctgcgtgat gaagtgttgc actccctgct tcctcgggcg ttctccaaaa actcgactgt    50760

tggtttgtgg atcaacgtca ccgacggtct gatcatggtt gatgcagcca gcgctaaacg    50820

tgccgaagac tcactggccc tgcttcgtaa aactctcggt tctctcccgg tggtaccgct    50880

gactatggaa acgccgatcg aactaactat gaccgactgg gttcgttccg gtagtgcgcc    50940

tgctggcttt ggcctgggtg atgaagccga actgaaagct attcttgaag atggcggtat    51000

tggacgcttt aaaaaacaga ctctggtcag tgacgaaatt catgtgcatc tggaagctgg    51060

caaagtagtt acaaagctgt ctatcgactg gcaacagcgc attcagttcg ttctttgcga    51120

tgacggcagc atcaaacgcc ttaagttctc taatgagatt acagaacaaa acgacgatat    51180

cgaccgtgag gatgcggctc agcggttcga cgctgacttt gttctgatga ccggcgagct    51240

tatctctctc attaacggat taacaacctc tctcggcggc gaagccaagc gataaacacc    51300

aggcaacaat tacccccata agcatgggtt gggttgctgc acgctaaatt cagcaattca    51360

ttaatttaat ggcgcggtgc agcgcgccaa tatggagaaa accatgagct acattcagac    51420

attatccggc aaacatttta attacctcga tatccaacag gacgatatcg tgatcgagga    51480

tattgctacc gcgttgtctc atatctgccg ctttgcaggg catcttcctg agttttacag    51540

tgtcggccag catagcgttt taaccagcca cctcgttccg caggagtttg cattagaagc    51600

actgcttcat gatgctgctg aagcctacct gcaggacatc ccctccccac ttaagcgcct    51660

gcttccggat taccaggcaa tcgaagctcg tgtggacgca gccattcggc agaagttcgg    51720

tctaccaact gagcaacacc caaccgtgaa atatgccgac ctggtgatgc tcgccagcga    51780

acgccgcgat tttgagattg acgaaggttc catttggcca tgcctcgagg gagttgtccc    51840

aacggattta ttcattatca acccagttcg tcctggccag tcatacggca tgttcatcaa    51900

tcgctttaac gagttgatgg agcagcgcca atgcgccgca tgaaggtaaa agaactcgta    51960

gcggaggcgt ttgcctccgt tgctgaattg ccaccaaagc atgcgccgct tatgcgcgaa    52020

gtcgccacca gactggacgc tacgttcgca gcattaaaag agtctctggt gcaactggaa    52080

caggaacgta aagataaaac gccatgaccg tatttgaata tctccaggct catccgaata    52140

ccaccagcgg tgaaatcgcc aaaggtatga acaaaaagac cccagcggtc gccggagcat    52200

tatctcagct ctatggcacc ggtcggatcg tgaagtctgg tgttcgcaag ggtattccaa    52260

cataccgcat taacgatatg ccgtttggtt gcagtaacag cctaaccatg atgtttaacc    52320

agctcttgag cagagccaga caaggagcag cccaatgaca gcactcaaca aacaggcgct    52380

gcgtgaagaa ttccagttca tgcaggacaa ctatagcgac ccggcagacc acgatcggca    52440

ggtgatttac atcgaggcgg aggcgctgct ggatgagttg gaagccaaag actcaacgat    52500

agcagcacaa caacatgaga tccgtatgtt gctgaatgcg cttgaggaaa aaccatgccc    52560

gaaatgcaac gacacaggaa tgactgatag tggcggcacg cagccatggg gcgagccgat    52620

tgagattgaa tgcgactgcc gacagcagga tgccaacacc gcagaacttg tagccgctgg    52680

cattggcgtg aagggggagt gagatggata aattaatcaa acctaccgcc aaaggtaaat    52740

atgacggttc atgtgattat ctttgctcgg aagatgcgcg attcatcgtt atgcgcggcg    52800

attatacgga agcggaaata attcaggctt ctgtgtctca agatgtaatc gactcggatg    52860

gtgcggctga ttttgcaagt agcgcccgct attatcagtg ctggtacaaa gttagcccaa    52920

taggtggtca ggatggctat tcaggctggc atcatcctcg tgattcgccg tgtcgcggtg    52980

catatttcgc atcagttttg caatgggatt aaggaggact aacccatgac aactaacaac    53040

cacccggcgc acggtcctgt atcactcgat cgcctgcacc agatacgcga acacctgctg    53100

catgataccc aatactcaaa cggcgggaac agagcctaca ttctcgctga tgtattgaag    53160

gtgattgatg gggctattgc ccgcgagctg gtacgccgtg agcatgcagc gtggtcacag    53220

gctactttcg gcgatgtcgg tccagttggt ccgctgaagc acctttccaa agaagcgctc    53280

gaggctgctg ctgaaccagg cgaccttagc gaatgggctg acatgcaatt cctgttatgg    53340

gatgcgcaac gtcgtgccgg tatcagtgat gagcagatta cccaggcaat gataaaaaag    53400

ctggctataa ataaggttcg ccaatggcct gagccgaaag acggggaacc tcgattgcat    53460

atcaaagaac agtcagagca ggagaaaaaa taagaatgtt tagcctgatt cggcgcggtc    53520

aaatctacac ggacagtagc aactggcccg taattatcca tagctgtagt gatcactcgg    53580

tccgaattaa acgcaatgat ggcgagctga gaacgattag catcaaacgc tttaacgaag    53640

attttgaacg agtggagcat gatgagtatc gcaaaatatg tgccgaaata gagcaggaaa    53700

caaacctgaa aaacctacgt gcgatgcgtc gcggcaagat tactgaatag ccaaacagga    53760

gaatatttaa cgtgaacaac ttaatgatcg accttgagtc catgggcaaa aaaccgaatg    53820

cccctattgt ctccattggt gccgtattct tcgatccgca aagcggtgaa ctgggtcagg    53880

agttttacac cgctgttaat cttgaaagcg ctatggagca gggagcggtg ccggatggtg    53940

acactattct gtggtggtta agacaaagct cagaagcacg atcagcaatc tgtgttgatg    54000

atgcgatgcc gatatcatct gccctatctg aactgagcca tttcattaat cggcattctg    54060

ataaccctaa atatttaaaa gtttggggca atggagctac tttcgacaac gttatattgc    54120

gcggcgcata tgagcgtgcc ggccaggttt gcccgtggca attttggaat gatcacgacg    54180

tcagaaccat cgtcacatta ggcagatctg taggtttcga tcctaagcgt gatatgccat    54240

ttgatggggt tgcacataac gcactggctg atgcccgcca ccaggcgaaa tatgtttcag    54300

cgatttggca gaaactaatc ccaaccacca gcaacagcta aagttttccc cgggtgcagc    54360

cgggataatg gagaaataac tatgagcaat attttccagt tagctcccaa cgattgggtt    54420

tgtgaaagcg ttttgatcgc ggttactggg ctcaaacccg gaaccatcct ccgtgccaga    54480

aaagaatgct ggatgattgg gagggagtat atccacgtat cgcctgacgg aaatcctaaa    54540

ccttccagtg agtgcatgta taacagaaag gctgtagatg cctgggtcgc ttcaatgaaa    54600

agcaagcaac cagggtgatt tgatgccatg aaaaaggtaa gctcgtatcg ctcttgggcg    54660

tctggaggta acaccaatgg ataaagtcac atatccaaca ggcgtcgaaa accacggtgg    54720

cacattacgc atctggttta attttaaagg taagcgtgtc agggaaagtc tcggtgtccc    54780

tgacaccgct aagaacagga agatagccgg ggaactgcgg acatcagtat gttttgccat    54840

ccgcacagga acctttgatt atgcaaccca gtttcctgac tcccctaacc tcaaggcttt    54900

tggtgtaagt aaaaaagaca ttacagtgaa agaacttgaa gaaaaatggc tggatctgaa    54960

acggatggaa atctgcgcga acgcatttaa tcgctatgaa tctgtcgcaa ggaatatggt    55020

gccgaggatc ggaggtaatc gcctggtgtc agcagtaacc aaagaggaat tgctgtatct    55080

gaggaaatat ttgctaactg gttatcagaa tccgacgaaa aacaaagccc cggcaaaagg    55140

gcgaagcgtt gttactgtga actattacat gacgacaatg gccggaatgt ttcagtttgc    55200

tgcggatcac ggttacttag aggtgaaccc attcgaggga attaagcctc tgaaaaaagc    55260

cagggcagaa ccagatcctc tgtctcgtga tgaatttatt cgcctgatag atgcatgccg    55320

gcatcagcag acgaaaaacc tgtggtcatt agcagtgtac acaggaatgc gtcacgggga    55380

actggtctcc ctggcctggg aagatatcga cctgaaggct ggaacaatta ccgtcagacg    55440

taattatacg aaacttggtg agttcactct accgaaaacc gaggcaagca cagatcgagt    55500

ggtgcatctt atccagcccg caatcagtat cctgaaaaat caggctgaaa tgacaaggct    55560

gggcaggcaa tatcacattg aagtgcagtt acgtgagtac ggccgttcgg tgaaccatga    55620

gtgtacattc gtctttaatc cgcatgtggt cagacgcagt aagcaggtcg gatttatcta    55680

ccgggtcgat tcagtaggcg actcatggga agcggcactt aagcgtgcgg ggatcagaca    55740

cagaaaggcg taccagtcac gacacaccta tgcgtgctgg tcattatcag ctggtgcaaa    55800

ccctagtttt attgccagtc agatggggca tgcgagcgcg cagatggtgt tcaatgttta    55860

cggtgcatgg atggctgaca gcagcgcaga gcagatcgca atgctgaatc agaagctggc    55920

agattttgcc ccattgatgc cccatagcca cgagaacagt acgggaggat tattaaaatc    55980

agtaagttaa cccctaacgc ccgtcatgtt aactgtgtgg agggtaacac cacgctttat    56040

gccctgccga aacccgaggt tgtcctgcgc tggcgtgagc agaccacaga tgacttccgc    56100

ttctgtttta agtttccggc gaccatttcg catcaggcag cattacggca ttgcgatgat    56160

ttagtgactg aatttttgac ccgcatgtca ccgttggctc cgcgcattgg acaatactgg    56220

ctgcaactgc ctgccacatt cggcccacgg gagctgcctg cgctttggca ttttctcgat    56280

tctcttcccg gtgaatttaa ttatggggtg gaagtccgcc atccacagtt tttcgccaaa    56340

ggggaagagg aacaaacgct taatcgcggt ttacatcagc gcggcgttaa tcgggtgatt    56400

ttagacagcc gcccggttca tgcagcacgt ccatacagtg aagctattcg cgacgctcaa    56460

cgaaaaaaac ctaaagttcc ggtacatgct gtactgacgg cgaaaaatcc actgatccgt    56520

tttatcggta gtgatgatat gacgcaaaac cgggaattat ttcaggtctg gttacaaaaa    56580

ttagcgcagt ggcatcagac cactacgcct tatctttttt tacatacgcc agatattgcc    56640

caggccccgg aactggtaca taccctgtgg gaagacttac gtaaaacgct tccagagatc    56700

ggagcagttc cggctattcc acagcaatct tctcttttct gaatttgcca cctatcatag    56760

acaggtgcca tcggccattt taaagggagt ttgtatggta agcgcgctgt atgccgtttt    56820

aagtgcgttg ttattaatga agttctcttt tgatgtcgtt cgcctgcgaa tgcagtaccg    56880

cgttgcctat ggcgacggcg gttttagcga actgcaaagc gctattcgca ttcatggtaa    56940

cgcggtggaa tatattccta tcgcgattgt gttgatgctg tttatggaaa tgaatggcgc    57000

agaaacctgg atggtgcata tttgcggcat cgttttgctt gctggtcgtc tgatgcatta    57060

ttacggtttt catcaccgtc tgttccgctg gcgacgttct ggcatgagcg ccacctggtg    57120

tgcgctgttg ctgatggtgc tggcgaatct ttggtatatg ccctgggagt tggttttctc    57180

cctgcgttag cgcacaatac gccactttct ttttcccgga tttttacgtt atgtctcacc    57240

gcgacacgct attttctgcc cctatcgcca gactgggcga ctggaccttt gatgaacggg    57300

tagctgaagt cttcccggat atgatccagc gttccgttcc cggctattcc aatattattt    57360

ccatgattgg tatgttagcc gagcgcttcg ttcaacctgg tacgcaggtt tacgatctgg    57420

gttgttctct gggcgcggcg acgctctcgg tgcgtcgcaa cattcatcat gataattgca    57480

aaattattgc catcgacaac tccccggcga tgattgaacg ctgccgtcgt catattgacg    57540

cctataaagc ccctacgcca gtagacgtta ttgaaggtga tattcgcgat atcgccattg    57600

aaaacgcatc gatggtggtg ctgaatttta ccctgcaatt cctggaacct tccgagcgcc    57660

aggcgttact ggataaaatt tatcaagggc tgaacccggg cggtgcgctg gtgctttcgg    57720

aaaaattcag tttcgaagat gccaaagttg gtgaactgct gttcaacatg caccacgact    57780

ttaaacgtgc caacggttac agcgaactgg agatcagcca gaaacgcagc atgctggaaa    57840

acgtgatgct gaccgattcc gtggaaaccc ataaagcacg cctgcataaa gccggttttg    57900

agcatagcga gctgtggttc cagtgcttta actttggttc actggtggca ttaaaagcag    57960

aggacgctgc atgatcgact ttggtaactt ttattctctg attgccaaaa atcatctttc    58020

acactggctc gaaacgctgc ccgcgcagat tgctaactgg cagcgcgagc agcagcacgg    58080

gctgtttaag cagtggtcca acgcggtgga atttctgcct gaaattaaac cgtatcgtct    58140

ggatttattg catagcgtaa ccgccgaaag cgaagagcca ctgagcgccg ggcaaattaa    58200

gcgcattgaa acgctgatgc gcaacctgat gccgtggcgc aaagggccgt tctcactgta    58260

tggcgtcaac atcgataccg aatggcgttc cgactggaaa tgggatcgcg ttatgcccca    58320

tctttctgat ttaaccgggc gcaccattct tgatgtcggc tgtggcagcg gttatcacat    58380

gtggcgcatg attggcgcag gggcgcatct ggcggtgggt atcgatccca cgcagctatt    58440

cctctgccag tttgaagcag tgcgtaaact gctgggtaac gatcagcgcg cacatttgtt    58500

accgttaggt attgaacaac ttccggcact gaaagccttt gataccgtct tttcgatggg    58560

cgtgctttat catcgtcgtt caccgctgga gcatctctgg cagttaaaag accaactggt    58620

gaatgaaggc gaactggtgc tggaaacgct ggttattgat ggcgacgaaa acacggtgct    58680

ggtgccgggc gatcgttacg ctcaaatgcg taatgtctat ttcattcctt ccgcgctggc    58740

gctgaaaaac tggctgaaga agtgtggttt tgttgatatt cgcattgcag atgtgagcgt    58800

taccaccaca gaagagcagc gacgcaccga atggatggtc accgagtctc tggccgattt    58860

tctcgacccg catgatccgg gtaaaacggt ggaaggttat cctgcgccta aacgcgcggt    58920

gctgattgcg cgcaagccgt aaaggtctgg taatactgcc ggatgcggcg tgaacgcctt    58980

atccggccta caaagtcttg ctaattcaat atattgcagg ggctatgtag gcctgataag    59040

catagcgcat caggca                                                    59056


<210> 1286
<211> 972
<212> DNA
<213> Escherichia coli

<400> 1286
ttatttgatg ggataaagat ctttgcgctt atacggttgg atttcgcccg gtttgcgagt       60

tttcagcaat tttaatatcc aggtgtattg ttctggtcgc ggaccaacaa aaatctcgac      120

ttcttcattc atccgccgcg caatcgtatg atcatccgcc tctaacagat catccatcgg      180

tgggcgcacc tgaatcgtca gacgatgcgt cttgccatca taaatcggaa atagcggtac      240

aacgcgcgca cggcacactt tcatcaaacg accaatcgcg ggcaacgtcg ctttataggt      300

ggcaaagaaa tcaacaaatt cgctgtgttc tgggccatga tcctgatcgg gtaaataata      360

tccccagtaa ccctgacgta ccgactggat gaatggttta ataccatcat ttctcgcatg      420

cagacgacca ccaaagcgac ggcgcaccgt gttccagaca taatcaaaaa ccgggttgcc      480

ctgattatgg aacatcgctg ccattttctg cccttgcgag gccatcagca tggcaggaat      540

atcgacggcc caaccgtgcg gcaccagaaa aatcactttc tcgttattac gtcgtatctc      600

ttcgatgatc tccagccctt gccagtcaac gcgcggctga attttctccg gcccgcgtat      660

tgccaactca gccatcatta ccatcgcttg cggcgcggtg gcaaacatct catctacaat      720

cgcttcgcgt tcagcttcac tacgttctgg aaagcagagc gacagattga ttaacgcacg      780

acggcgtgag ctttttccca gtcgtccggc aaaacgtccc agccgtgcca gaatgggatc      840

acggaacttt ggcggcgtta aagcgatacc cgccatcgct gctacgccca gccatgctcc      900

ccagtagcgc gggtggcgaa aggatttatc aaactcagga atgtattcgc tattattttt      960

tttcgtttcc at                                                          972


<210> 1287
<211> 1323
<212> DNA
<213> Escherichia coli

<400> 1287
ttaatcaaac cgtagctgcg gcacaatctc tttggcctgt gccaggaatt cgcgacgatc       60

ggagccggtc agcccttcgg tacgcggcag ttttgccgtc agcgggttta cggcctgctg      120

gtttatccat acttcatagt gcagatgcgg cccggttgaa cgtccggtat taccggaaag      180

cgcgatacgg tcgccacgtt tcaccttctg tcccggtttc accaggatct tgcgcaagtg      240

catataacgc gtggtgtagc tgcgaccatg acgaatagcc acataataac ctgctgcgcc      300

actacgtttg gcaaccacca cttcaccgtc acccactgaa agcactggcg taccttgtgg      360

catggcaaaa tcaacacctc tgtgtggcgc aacgcgaccg gtcaccggat tagtacgacg      420

cgggttaaag ttagatgaga tacggaactg tttcgccgtc gggaatcgca agaatccttt      480

cgccagacca gtaccgttac gatcgtagaa tttgccatct tcagcgcgga ttgcgtaata      540

atctttacct tctgaacgca aacgtacgcc cagcagctgg ctttgctcac gtttaccatc      600

aagcatttct cgtgacatta acaccgcaaa ttcatcgcct tttttcagtt tgcggaaatc      660

catttgccac tgcatggctt taatcactgc gctcacttcg gcgctggtta aaccggcgtt      720

tctggcgctg gcaacaaagc ttcccccgac ggtacctttc agcagattgt tgacccactc      780

tccttgctgc atttcgctgg tcattttaaa accgttagcg gcagtacggt cataggttcg      840

ggtttcacga cgagacactt cccaggtgag gcgctgcagt tcgccgtccg cggttaatgt      900

ccaggagagt tgttgaccga ttttcaggtt acgcaattct ttgtcggcag cagccagttg      960

ggtgatatca cccatatcaa taccatactg attgagaatg ctgcttagcg tatcgccagt     1020

ggaaacaaca tattcatgca cgcccgcttc accggcgatt ttgtcatcca gttcgtcctg     1080

gggaatggct tcatcttctt gtgcagcttg atcaatcggc tcactggctt caggtaagag     1140

cgaacgaatt tcgttctgtt ccagctcaat ggttttgaca attggcgtgg catcgcggtg     1200

ataaacatag ggccgccaga cagcgacggc cagagtaaga acggtgagcg accccaacat     1260

aacgcggtgt ggtcgcggta aattattaaa cgccagggcg acagagcggg ctatctgttg     1320

cac                                                                   1323


<210> 1288
<211> 933
<212> DNA
<213> Escherichia coli

<400> 1288
ttaatctcct ttcaggcagc tcgcatactg gttggctaat tgattcagga attctgaata       60

gcttgtttta cccagtttga tattcgtccc caggggatcc aacgttccca tacgaacgga      120

tgtccctcgt gcgacgctct caacgaccgc tggcctgaac tgtggctcag caaaaacgca      180

ggttgctttt tgctcaacca actgtgttct tatttcatgt aaacgctgcg cgccaggttg      240

aatctcaggg ttaacggtaa aatgaccaag cggtgtcagt ccgaactgtt tttcgaaata      300

gccgtaagca tcgtgaaaaa cgaaataacc tttccccttg agcggcgcga gctcgttacc      360

aacctgcttt tcggttgagg ctaattgtgc ctcaaaatcc ttcaggttgg cgtcaagttt      420

ggctcgactt tgcggcataa gttccactaa ttttccatgg attgcaaccg ctgtagcccg      480

cgctatctct ggggaaagcc aaagatgcat gttgaaatcg ccgtgatggt gatcttcgtc      540

acttttttcc gcgtggtcgt gatcatcatc atcgccgtga atacttttca tcagcagcgg      600

tttcacattc tctagctgcg caatcgttac ctgtttcgct tcaggtaatt tacttaccgg      660

tttttgcatg aacgcttcca tctccgggcc aacccaaacg actaagtccg cgttctgtaa      720

gcgttttaca tctgatggac gcagtgaata atcatgttct gaagccccgt caggtagtaa      780

aacctccgtt tctgttaccc catcagcaat ggcagaagcg atgaacccaa cgggtttaag      840

cgaagcgaca acggcagcat ctgcggcctg tgttgcaccg ccccagagag cggcggataa      900

tgctgcgaaa agaagcgttt ttttatgtaa cat                                   933


<210> 1289
<211> 756
<212> DNA
<213> Escherichia coli

<400> 1289
atgacaagtc tggtttccct ggaaaatgtc tcggtttctt ttggccaacg ccgcgtcctc       60

tctgatgtgt cgctggaact taaacctgga aaaattttga ctttacttgg gccaaacggc      120

gcaggtaagt cgacactggt acgggtagtg ctcgggctgg taacacccga tgaaggggtt      180

atcaagcgca acggaaaact gcgcatcggc tatgtaccgc agaagctgta tctcgacacc      240

acgttgccac tgaccgtaaa ccgtttttta cgcttacgcc ctggcacaca taaagaagat      300

attttgcctg cactgaaacg tgtccaggcc gggcatctga ttaacgcacc gatgcaaaag      360

ctctcgggtg gcgaaacgca gcgtgtactg ttagcgcgag cattgttaaa tcgaccgcaa      420

ttattagtgc tggatgaacc cactcagggc gtggatgtga atggtcaggt ggcgttatat      480

gaccttattg accaactgcg tcgcgaactg gattgtggcg ttttaatggt atctcacgat      540

ctgcatctgg taatggcaaa aaccgatgaa gtgctttgcc tgaatcacca catttgttgt      600

tccggcacac cggaagttgt ttccctgcat ccggagttta tttctatgtt tggtcctcgt      660

ggtgctgaac aactgggtat ctatcgccat catcataatc atcgtcacga tttacaggga      720

cgaattgttt tgcgtcgggg aaatgatcgc tcatga                                756


<210> 1290
<211> 786
<212> DNA
<213> Escherichia coli

<400> 1290
atgattgaat tattatttcc cggttggtta gccgggatca tgctcgcctg tgccgcgggt       60

ccgctgggtt cgtttgtagt ctggcgtcgt atgtcttatt tcggtgatac gctggctcat      120

gcctcattac ttggcgtcgc gtttggtttg ttgctggacg tgaatccatt ctatgcggtg      180

attgccgtta cgctgctgct ggcgggcggt ctggtatggc tggagaagcg tccacagctg      240

gcgatcgaca cgttattagg gattatggcg cacagtgccc tgtcgctggg cctggtggtc      300

gttagtctga tgtctaatat tcgtgttgat ttgatggctt acctgttcgg tgatttactg      360

gcagtgacgc cagaagatct catctctatt gcgattggcg tggtcatcgt ggtggctatt      420

ttgttctggc aatggcgcaa tttgctgtcg atgacgatta gcccggatct ggcgtttgtt      480

gatggtgtga aattacagcg cgtgaaattg ttgttgatgc tggtgacggc attgacgatt      540

ggtgtagcga tgaaattcgt cggcgcgttg attattactt cactgctgat tattcctgct      600

gctactgcac gtcgctttgc ccgcacgccg gaacagatgg ctggtgtcgc tgttttggtg      660

gggatggtgg cagtgactgg cggtttaacc ttttccgcat tttacgatac acctgcaggc      720

ccgtcggtgg tgctatgcgc ggcactgtta tttattatca gtatgatgaa aaagcaggcc      780

agctaa                                                                 786


<210> 1291
<211> 1011
<212> DNA
<213> Escherichia coli

<400> 1291
ttacggcatt tctggcggcg tgatgccgaa gtggttccac gcccgcactg tcgccatacg       60

cccgcgcggt gtacgctgca aaaagccttg ctgaatcaaa taaggttcca gtacatcctc      120

aatggtttca cgttcttcgc caatggctgc cgccaggtta tccagaccta ccggcccacc      180

aaagaactta tcgattaccg ccagcaacaa tttgcggtcc atataatcga aaccttcagc      240

atcgacattc aacatatcca gcgcctgagc agcgatatct gccgagatgg tgccatcgtg      300

cttcacttca gcgaaatcac gcactcgacg cagcagacgg ttggcaatac gtggcgtacc      360

gcgcgcacga cgagcaactt ccagcgcgcc gtcatcactc atctcaagcc ccataaagcg      420

tgcgctgcga ctgacgatat attgcagatc cggcacctga taaaactcca gacgttgcac      480

aataccaaaa cgatcgcgca acggtgatgt cagcgaacct gcgcgcgtgg ttgcaccaat      540

cagggtaaac ggcggcaaat caattttaat ggagcgtgcc gccggacctt caccaatcat      600

gatatccagt tggtaatctt ccattgccgg atacaacacc tcttccacca ctggtgaaag      660

acggtggatc tcatcaataa acagtacatc gtgtggttca aggttagtga gcattgctgc      720

cagatcgccc gccttttcca gcaccggacc agaagtcgtg cgtaaattaa cgcccatttc      780

attggcgaca atattggcaa gcgtagtttt acccaacccc ggaggaccaa aaatcaatag      840

atgatcgagg gcatcgccgc gcagtttcgc tgctttgatg aaaatctcca tctgcgaacg      900

aacctgcggc tgaccaacat actcttccag taatttaggg cgaatggcgc gatctgccac      960

atcttccggc aaagtggtac cggcagaaat cagacggtct gcttcaatca t              1011


<210> 1292
<211> 612
<212> DNA
<213> Escherichia coli

<400> 1292
tcataacgcg gcgcgtaggg cttcgcgaat taatgtttca ctgctggcgt cagggcgagc       60

gattttgctc accatgcggc ttgcttcttg tggtttatag cccagtgcca ccagcgcagc      120

aaccgcttcc tgttcagcat cgtcggtcgc cgggctggca ggagacgtga gtaccaggtc      180

ggcggctggc gtaaagagat cgccatgcaa acctttaaat cggtctttca tttcgacaat      240

caagcgttcg gcggtttttt tgccaatacc cggcagtttc accagtgccc ccacttcttc      300

acgctcaacg gcattaacga actgctgcgc tgacattccg gagaggatcg ccagcgccaa      360

cttcgggccg acgccgttgg ttttgatcaa ctctttgaac aacgtgcgct cttgtttatt      420

gttaaaaccg tacagcagtt gcgcgtcttc acgcaccaca aagtgggtga aaacgatcgc      480

ttcctgaccc gcttcaggga gttcataaaa acaggtcatc ggcatatgca cttcatagcc      540

tacgccgccc acttcaatta acaccagcgg gggttgtttt tcaatgatga tgcctctgag      600

tctgcctatc ac                                                          612


<210> 1293
<211> 603
<212> DNA
<213> Escherichia coli

<400> 1293
gtgaatatta attatcctgc tgaatatgaa attggtgata tcgtctttac atgtataagt       60

gctgccttat ttggtcaaat atcagctgca tcaaattgct ggagtaatca cgtcgggatc      120

attatcggtc ataacggtga agactttctg gttgcagaaa gccgtgttcc cctctcaacc      180

atcactacgc tatcccgttt tattaaacgc tctgctaatc aacgctatgc tataaagcga      240

ttagacgccg gactaacaga acaacaaaat caacgaattg ttgaacaggt tccttcccgg      300

ctacgcaaaa tttaccacac cggttttaaa tacgaatctt cgcgccagtt ctgttcaaaa      360

tttgtttttg atatttataa agaggcgcta tgtattccgg tgggtgaaat agagacgttt      420

ggagaattgt taaatagcaa tccaaatgca aaactcactt tctggaaatt ctggttctta      480

ggttctattc cgtgggagcg taaaaccgtc acgccagcca gtttgtggca tcatccgggt      540

ttggtgttga ttcacgcggt gggagttgaa acgcctcagc ctgaactgac cgaggcggta      600

taa                                                                    603


<210> 1294
<211> 522
<212> DNA
<213> Escherichia coli

<400> 1294
ttaacgcagt cgccctctcg ccaggttcag tcgcgattcg ctcatttgca tcgcattctg       60

actaacgtgg cagtgggtga tggcaatcgc cagcgcatcg gcggcatccg cctgtggatt      120

agcgggcagt ttcagcaagg tgcggaccat atgctgcacc tggctttttt cggcactacc      180

aatacctacc actgtttgct ttacctgacg tgccgcatat tcaaataccg gcaattcctg      240

attcaccgcc gccacaatcg ccacgccgcg cgcctgcccc agtttcaggg ctgagtcagc      300

gttcttcgcc ataaagacct gttcaatggc gaaataatca ggctggaatt gggtgatgat      360

ttccgtcacg cccgcataga tgagcttcag acgagacggt aaatcatcca ctttggtgcg      420

tatgcatccg ctacccaggt aggacagttg cctgcctacc tggcggatga cgccatagcc      480

ggtcacgcgc gaacccgggt caatgccgag aataatagcc at                         522


<210> 1295
<211> 741
<212> DNA
<213> Escherichia coli

<400> 1295
tcagagagtc gctgcaacct catcagagat ttcaccgtta tggtaaactt cctgcacgtc       60

gtcgcaatct tccagcatat cgatcagacg catcagtttc ggtgcggttt ctgcatccat      120

atcagctttg gtggacggga tcatggaaac ttccgcgctg tctgctttca gacctgccgc      180

ttccagagcg tcgcgtactt tgcccatttc ttcccatgca gtgtagacat caatcgcgcc      240

gtcatcatag gtcacaacgt cttcagcacc ggcttccagg gctgcttcca tgatggtgtc      300

ttcatcgcct ttctcgaagg agatcacgcc ttttttgctg aacaaataag ctacggaacc      360

atcagtaccg aggttaccgc cacatttgct gaatgcatga cgcacttcag caacggtacg      420

gttgcggttg tcagacagac attcaatcat gattgccgtg ccgccaggac cgtaaccttc      480

gtagatgatg gtttccatgt ttgcatcatc atcaccgccc acacctcgtg caattgcgcg      540

gttcagagtg tcacgggtca tgttgttaga cagtgcttta tcaattgctg cacgcaaacg      600

cgggttagcg tccggatcac caccgcccag cttagccgcg gttaccagct cacgaatgat      660

tttagtgaag attttaccgc gcttagcatc ctgcgcagct ttacgatgtc tggtgttggc      720

ccatttacta tgacctgcca t                                                741


<210> 1296
<211> 444
<212> DNA
<213> Escherichia coli

<400> 1296
tcaggcagcg ttaattacaa actgttcaat cgcctgccgg ttgctccagg acttagtgag       60

cgccgccgca gcagacgcat caagccactt gtaagccaga tgttcagtga aaacgatctg      120

gcgctcgtgc ggaagcgcaa gacagaacca tgattccgta ttacgcgtca cgcccggcgc      180

atagcgatga cgtaaatgtg aaaaaatttc aaactctacc gtgcgctgac agtcaattaa      240

ggtcagttgt tcagcgacaa catcaatggt gacctcttcc tttacttcgc gcatggcagc      300

ttgcggcgcg gtttcaccct cttccacgct gccggttacc gactgccaga aatcgggatc      360

gtcacgccgc tgcaacatca gcacccgttt cgtatcttgt gcgtagatga ccactaagat      420

cgaaacggga cgcttataag ccat                                             444


<210> 1297
<211> 1773
<212> DNA
<213> Escherichia coli

<400> 1297
tcagttattc tcagccttct tcacaacctg aatgctcagc tcagccagtg cagtcgggtt       60

agcaaagctc ggcgcttcag tcatcaaaca cgctgccgcc gtggttttcg ggaaggcgat      120

aacgtcacgg atattgtcgg tgccggtcag cagcatcgtc agacggtcaa gaccgaatgc      180

caaacctgcg tgcggcggag taccgtattt cagggcgtcg agcaggaagc cgaatttctc      240

gcgctgttcc tcttcgttga tacccagaat accaaacacc gtctgctgca tatcaccatt      300

atggatacgc acagaaccac cgcccacttc gtaaccattg atgaccatat cgtaagcgtt      360

agccaccgca ttttccggtg cagctttcag ttctgctgcc gtcatgtctt tcggtgaggt      420

gaacggatgg tgcattgctg tcaggccgcc ttcaccgtcg tcttcaaaca tcgggaagtc      480

gataacccac agcggtgccc atttgctttc gtcggtcaga ccaaggtctt tacccacttt      540

caggcgcagt gcgcccatcg cgtcggcaac aattttcttg ttgtcggcac cgaagaaaat      600

catatcgcca tcttgcgcgc cagtacgctc caggatggct tcgatgattt ctgcattaag      660

gaacttcgct accgggctat tgataccttc cagacctttc gcgcgttcgt taactttgat      720

gtaagccaga cctttcgcgc cgtagatttt aacgaagtta ccgtattcgt cgatctgctt      780

acgggtcaac gatgcgccgc ccggaacacg cagagcggca acacggcctt tcggatcgtt      840

cgccggacct gcaaatactg caaactcaac agatttcagc agatcggcaa cgtcggtcag      900

ttccatcggg ttacgcagat ccggtttatc agaaccataa cggcgttctg cttctgcaaa      960

ggtcattacc gggaaatcgc ccagatccac gcccttcact tccagccaca gatgacgcac     1020

cagcgcttcc atcacttcac gcacttgcgg cgcggtcatg aaagaagttt ccacatcgat     1080

ctgagtaaat tcaggctgac ggtcagcacg caggtcttcg tcacggaagc atttaacgat     1140

ctgatagtag cggtcaaagc cggacatcat cagtagctgt ttgaacaact gcggggattg     1200

cggcagcgcg tagaatttac ctttgtgcac acgagaaggc accaggtagt cacgcgcgcc     1260

ttcaggcgtg gctttggtca gcatcggagt ttcgatgtcg aggaagccgt ggtcatccat     1320

aaaacggcgc accaggctgg tgattttagc gcgggttttc aggcgctgag ccatttccgg     1380

gcgacgcagg tcgaggtagc ggtatttcag acgcgcttct tcggtgttga cgtggttaga     1440

gtcaagcggc agaacatctg cacggttgat gatagtcagc gaggacgcca gtacttcgat     1500

ttcgccagtc gccatatcgc ggttaatatt tttttcgtca cgcgcacgta cggtgcccgt     1560

gacctgaatg cagaactcat tacgcagttc agaggccagc tttaacgcgt ccgcacgatc     1620

cggatcgaaa aatacctgca cgataccttc gcggtcgcgc atatcgatga agatcaggct     1680

accaagatca cgacgacggt tgacccaacc acacagagtc acctgctgcc ccacgtggga     1740

caaacggagc tgtccacaat attctgtacg cat                                  1773


<210> 1298
<211> 567
<212> DNA
<213> Escherichia coli

<400> 1298
atgcttgaac ttaatgctaa aaccaccgcg ctggtggtga ttgatttaca agaaggcatc       60

ttgccttttg ccggaggtcc acatactgcc gatgaggtgg ttaatcgcgc cgggaagctg      120

gcggcgaaat ttcgcgccag cggtcagccc gtgtttctgg tgcgcgttgg ctggtctgcc      180

gattacgccg aagcattaaa acagccggtt gatgccccct cccccgcaaa agtgttgccc      240

gaaaactggt ggcaacatcc tgctgcatta ggtgcaaccg acagcgatat cgaaatcatc      300

aaacgtcaat ggggtgcgtt ttacggtacg gatctggagt tgcaattacg ccgccggggt      360

atcgatacaa tagtgttatg tgggatctcg accaatatcg gtgttgaatc caccgcccgc      420

aatgcctggg aactcggttt taatctggtg attgccgaag atgcctgtag cgccgctagc      480

gccgagcagc acaataacag cattaatcat atctacccgc gcatcgcccg tgtgcgtagc      540

gttgaagaga tcctcaacgc gttatga                                          567


<210> 1299
<211> 390
<212> DNA
<213> Escherichia coli

<400> 1299
tcacatcacc gggcagtcat caaactccgc attcctggca tcattaatga tgtacgtgat       60

cactccaaat atagcgggtg cagaactgta accatcatca tctgctggca gcgcttccct      120

tctcccgtta tccagattaa ccaggtgcgg ctgaggatga gtccgatatc gcttgatcct      180

gaattccccg tcgattgcac atatcagcag tgaaccatcg caggcagtaa gtgacgcatc      240

cacaacaagc aacgctccct ggattatccc ttccctgaaa tgtgaacgcg atgcccgcat      300

gaaataagtc gctgcgggct gactgattag ctgctgatcg agggagattc gtgtttcaac      360

ataatctgcc gcaggtgaag gaaatcccat                                       390


<210> 1300
<211> 243
<212> DNA
<213> Escherichia coli

<400> 1300
atgttcgtgg aactcgttta tgacaaaagg aattttgatg gtctgcccgg tgcaaaagat       60

atcattctgg gcgagttaac taagagagtt caccggatct tccccgatgc tgatgttcgg      120

gttaaaccga tgatgacact gccggcgatc aacactgacg ccagcaagca tgagaaggaa      180

cagataagcc gtactgttca ggaaatgttt gaagaggctg aattctggtt agtgagtgag      240

taa                                                                    243


<210> 1301
<211> 381
<212> DNA
<213> Escherichia coli

<400> 1301
atgctgtgga ggatattcat tttcgtaaac gttggtttgg gagaagcggc aaaacggaat       60

gtgggaacag gggaaaatca gataccagat atgtctgcat ttccatctgg caataactgg      120

tttcagttac caagtggaca tatcgttcag atattttcca tgaacgttct tggtgcagat      180

gctaatggca cgtcagctaa ttaccccatt gcttttccaa caacgatgat tgctgtcagt      240

gctctatggt ctgatgggac tgtagcaaat gcaccgacat acaagatgat ggggaacacg      300

actaacagaa caactttgac gataaaagta tcagccagct caggtactta cgggacaatg      360

attattgcgg tgggacgata a                                                381


<210> 1302
<211> 444
<212> DNA
<213> Escherichia coli

<400> 1302
atgaataaat acagttactc tccttcagaa aatgcctttt atgctgttgc gttaaaaaat       60

acctatgaat tgagtggcac atggccagct gatgcattag atattcctga tgacatttct      120

gtaaaatata tggcggaacc gccacaaggg aaaatccgag ttgcagggga aaatggtttt      180

cccacatggg ctgaaatacc tccaccatca catgaggaac ttattgaaca ggccgaatca      240

gagaggcaat tattgattaa ccaggccaac gaatacatga acagtaaaca atggcccggt      300

aaagccgcta ttggtcgtct gaaaggcgag gaactggcac aatataattc gtggctggat      360

tatctggacg cactggaact ggtcgatact tccggtacgc ccgatattga atggcctacg      420

cctccggcag ttcaggccag atga                                             444


<210> 1303
<211> 594
<212> DNA
<213> Escherichia coli

<400> 1303
ctacgcctcc ggcagttcag gccagatgac atccggcgcg gtgctggtat ctgttgcagt       60

caccgcgtca atgtaatcca gcacggcgtt aagtcgggtt gtttctgcct gagtcagttt      120

ccgtccggcc tgtaatttca gctgaatcag actaatggaa gccattgctg catcaatcag      180

tgattggcgc tgtgcttctg ccgcttctac tgaggcaccg tgttgtgcct cagtatctgt      240

cacccatttc tcaccatccc atttatcata tggcgttaac ggtgaaagcg tgacataacc      300

gtttttgatg gcaccgatat aatccactgt aacagctgcg ccattttcga ttgagtaaac      360

agtctcattg cgatggtctt cctcatggct ccatccctta cctgtaaata ctgccactct      420

tcccggaatg ttttcgtccg ggtcaatacc agtggaacag gcgggcatac ttacgccagt      480

attaatatat tcatcagacc agcccgtata ttcagacgtt actgcatcat aataaaaaca      540

acgcatatca cccggcactg cagccagccc attttcatca aaaacaggtt tcat            594


<210> 1304
<211> 933
<212> DNA
<213> Escherichia coli

<400> 1304
ttatttagcc ctcaccagaa agttaaatgc aatatttcgc ggtctgacag caacaaaatt       60

cacaccatca cccacagagt tactgttgaa attaaatcgt gaaaatcctg gctgatttcc      120

ggcgatgcca tcatgaaagt taattgcgtg tccagcacct ccgcctatat tcccggcaaa      180

ctgagaaaag tttgtagctt cctgccagct taataattcg cgaccaccat ctgcacctcg      240

cccgtcatcc cagacacgaa tgaaatcacc gcgggcttca ggtaatacca gcgaaggaaa      300

cactttcgcc agcacaggat aatcagtggc agagaatttc gcgccgttga acttcaaaaa      360

caccatactg gaccagctgt cgattacagt atttggcatt gcagcggacg gccagaagaa      420

cggaacgcca atagctggag aaccttctcc caaaccaagg tttgtgcgag cgtctgcggc      480

attcgttgcg ccggttccgc cgtctgcgac agtaaccgca ccgttgctcc ctttctgcgc      540

aagtttaccg atgcctggga tggttacggc ggtgccgttg atggtaactg tgatgctttg      600

gtttgctgag gtggtggcga acgtctccca cgcgccaata ttctcgtcgt actctttgat      660

gagctgtgac atggcctgcg ccaggccgtc gactgagata ttgtccgaca caaggattcc      720

atacttctgg ccgctcagcg ccggggaaac tgctggcgta accgtcattg acgtggcgct      780

gttcacggat gaaatctgaa acagctgcac cgggttagac atcacgataa tcgtctggcc      840

agcgcggacc tggctggcgg gagctgtcca gtttgtgccg gagccggttg cggtatttcc      900

gttaatagag atagttccgg tgctataaat cat                                   933


<210> 1305
<211> 3927
<212> DNA
<213> Escherichia coli

<400> 1305
ttaacctgtg aatgaaccag atccgtgtga tactatgata gtaggcgaag aaattgacgc       60

acccctgtta ttttgagcgg acactttaat acgcactgtt acgtttggac ctgttacaac      120

cgcagaatgc atgataagtc tctccatgtc ttgcacggat gaaccactct cattgccgtt      180

aatgtcgatt gttcctgcac cattaccttt aacgtttgct ataacacaga cgtgtcttgc      240

gtgcccagaa ctggatgaat cattataagt cattaccttt tctaaatatc cgtcactaga      300

ccgactcaca ttcgtccctg tgtgcatatt tgcaatgtcc ccgataaaac tttgggcttc      360

cacagtccct ttgaatttac cgcttgttgc ttggatctca ccagtaaagc taccgccact      420

agcatatact acacctctga cggtcacatt gttgaattca gcatctccag ctttattcaa      480

cttccaacca gcagaaccag ctgcatagtt gttggactgg atatagttac cgatttttgc      540

gttctcaatg gtgccgtcct ggatgaagct ggcccggatg aatgtctgcc cgttctggat      600

cacgaacggc aaagctacgc tatttccggc tgccgtggtg acggcgaagc ggtcagccag      660

gaagataacc tgcgactgca tgccggatgg cgtattctcc acgccgatac ccatccccgc      720

ggcgtaatac tgcccgttgc tggagacacc aaccttgatg ttgtacatcg cgctgagttc      780

gccattaacg ttggctatag cctgagcgtt agtggtgatg gcggaggtat gcccgttcac      840

ggtcgccgtg atgccgttta tctgcgtggc ggtggcctgc tgatagtcgg agagcgtctg      900

attcaggctg ttgatggatg ccttgttgcc gttgacgtcc gtctgcaggc tcagcaatga      960

acgtgctgtg gcttccttct cactgacgat cacctcgtcg agacggtcca gattcgcgct     1020

gttgccggcg accgatgcag aaagggtttt acgcgtggcc acctgagcga ggttggcctg     1080

gattatcgca attgcagagt tcttcacccc gcccgtcatg ccgtccatag aaacgctgat     1140

gttgtcgatt cgctggccca gggcggtatc agccgtcgca acggtctgct caagctgact     1200

gagtgaagac gaaacattcc cgaccgtgct ggaaagctca ttaacgctgg tctgaacctt     1260

cccgacgtcc tgggcatttt tggcgatatc tttcgcttgc tgctccagtt cgtcgttggc     1320

ctgtttgata tcgttagcca tgccagcaat tttttcgttg ctgtccaccg cgttctcgat     1380

caggtctttg aacgtttccg actctttcat atcctccaga atgtcattag ttatttcgct     1440

gacatctatc gaggacgtgc ccatgatcca gtcggtccag tccccggcgt taccgatacg     1500

gtcaatcagg cgcgcgcggt accactggcg aacgccggca ggcatggggc catgctgata     1560

atctgcagcc gggtacggca ccaggaccag cagttcagga ttggcgtagt cggcagttgt     1620

ggcgcgctga atctctgtat aggccgtgtc gcctgagcca tccggaaatt tccaggtcag     1680

gtcgatatgc cagaccacat cttcggtcgc caggaagttg agcggagtac ccggttttcc     1740

cgttttaccg gagagataag ttgtttcacc gtatccccat ggtgacgacg tatcctgcgc     1800

attcagcgcc cgtacgcgca cgtcatagct gcccgaataa atgccctgaa ccgagaaacc     1860

ctgcgcgctg gtaaccggaa cgtttatcca gtccccgttg tccttacgcc actgggcaac     1920

ataccggatt gcgccctcta ccttatccca tgacacgtcc aggcttgcta cagtcagccc     1980

ctgagacaca tgatcgctct cagtcaccac gatattcttc ggagcagaca ggacgcttat     2040

cggcgtgacg gtgatcgggg gagactcgac ccgaacgccg tcatcgatgt aacgatattt     2100

gtttggatcg tgctgaacgg ccgtaatagt gaaaccgcct gtactgtcgt cgttagccgc     2160

gattgaggtg accctgaagt actgtattgc gaggttatca ctgtctatcg cccaaacagc     2220

gcccgccaca ggaacctgac tgaatgccgt agccaccgtc accgtttttt tatcggcgct     2280

caccgcgctg attgtccgcg tctgggcttt tccgtcggga aggttaacca ccagccggtc     2340

tttcgccgcg tagtctattt ctcgatcgag ggtaatttgg cggccgttgg ccgcgcttat     2400

acggcccccg ttctccttac cagagcggaa aggatcggcg acaccgataa tttcagcggg     2460

caaagggata taaccgtcca gccccacgcc aaacgatacg gtcccgtctt tggcattgga     2520

gagcaatacc cagcgaccgc gtcggtgcgc ttcactttgc gaggtgcagc cgattgcggt     2580

cagggacgtc tgccggacgt cgtaacgttc tacaagcgcc gaatcgtaaa ccccctcaac     2640

ggtatcgctg taatggttct gcggatcgga ccaggacacc aggcaggagc tgtagcgatt     2700

cttgtatgag ccgcccgcat aagtaaacag cccatcgata acgtttgaga cgttataaac     2760

ccagtcaaca tcgtcctgcg ggacgtctgc ctggacataa atctgatcgt ttccccagaa     2820

cgttattcca cgaaataccg cggcgagatc gttaagtacc tgccaggcgt cctcctggct     2880

ctgaatgaaa acgttgcagg tgaaacgcgg ttcggtgcca ccggccccgt cggaaaccat     2940

ttcgtcacag tactgggcga ttgaatacag cgcccactta tccaccatgg acgcatccac     3000

gcgcgtgccc atgccgtaaa tttcatccag aaccagatcg taaaagatcc aggcagggtt     3060

attggaccat gccattttga acccgccgga ccatgaacca gaataggttc gggttttcgg     3120

atcgtaatta tccggaacct taatcagctt gccttttatc ttacaggtca ctttcggcgc     3180

gctgccgttg aattggctgc tgtccacttc gacatacagg agcgctgtta aaggataacg     3240

aagcttgctg tcgatgactt ccgcatacga aaacaccttg aaggcgttaa ccagtttcga     3300

atttgatccg ctggcatcag ccgtaatacg cctgaccctg acagaccagc cggacgtgga     3360

ttttggcaga tcgatacggt ggtcacgctg atattccgtc gtggtctttc cgtcaaactt     3420

gccgtttaca accgttttcc aggcgccgcc gtccgttgat aaatcgatcg catactcggt     3480

gaccgtgccc accatatcgc cattatcttt atagagatac tggaccggaa ggctgagctt     3540

gatacggatg gcatccaggg aaaggtttgt aaactggcgc gtccagggcg cggtggtggt     3600

gacagttgtg cccacggcca gctcgttgtc gacctggggc atcccggcaa tataggtctg     3660

gtcctgtgtg cccttgcgga actcccattt cacgccgctg aagttgtatt ccccgctgtc     3720

gtttgccagc ggcgtatcgt tgagaaaaat gttctgagcg gtcaggtcgc cctgtatttc     3780

cccctcagaa acggcaatga gcatttttaa ttttgcgacc gacagcagat cgtcaggctg     3840

ctcaaccgga gtatgtgaac tgccacctcc ccctttggca ccctgcagga tggtttcttg     3900

tttaagaagc tgcatttttt cacccat                                         3927


<210> 1306
<211> 618
<212> DNA
<213> Escherichia coli

<400> 1306
ctactgctga tcgctcgagt acataccggc gctgactatc gctccccctg cctcagtcag       60

accgtaggcc agggggacag gatgccccat agcgacggta ttgaccggcg ccccgaaggc      120

gtagttaggc gtgttgtccg tgctggagga tttacccgcg ccgaaggatg gctggggcgt      180

gagcatctgg acaacgcccc ccagcatcat cgacactccg acccctgtca gaattgacgt      240

ggcgctgata gctgttgcac tcatcgccgc gccccaggct gccatgctcg caccagcggt      300

aaagaatgca gcgaccagcg caacagcccc gacaactatc tgcaggacgc ccgaactttt      360

ggccccctca taaacgggca cgatccggta cacgcttcca ccgcgggtca tatcaaactc      420

ttccagcccg atattgttgc caccgttaaa aaaggcgaaa cggatcccct tcatatgagc      480

ttcagacata tattttttga atccgggaac ctgtgaacac atggccctga gcatctcgcg      540

caggtcggca acatcaaact gaacgcgttt accgaatttt tttgccattt taccttcgag      600

aataagcgtc ttaaccat                                                    618


<210> 1307
<211> 720
<212> DNA
<213> Escherichia coli

<400> 1307
ttaaccatgc attctgtcct tatgcctgac cacccggacc gttctgtcgc gataatattt       60

tccataaggc gttcgcgaag aaaggtgccc gaaaagatga tggagaatga tgttatcacc      120

cacatatacc gcggcgtgat tagtcaccga tgcctgcaca ctcatcatga tgatatctcc      180

gggctgcatt gcaccggcgg caatctcaac gaatccctca cgctcccagt tgtcgtcgta      240

gagacgctcc ttgccgctct cccaccattc gtaaggtact gaataattgc cgagaacaat      300

gccgtattcg cgcagataaa attcacggat aagcgaccag cagtcggcgt aacccagcac      360

ccactgccgc ccggcataat cccggtcttc acgcggggaa atcgtacaaa aatccccgtc      420

cggccaggac atgatccccc actcaatccc cgaccagtcg cactggatcc ggtccagctc      480

tgagggcacc agccgaacca catccggatg ggaatgaatg agcatgatga tctcaccgcg      540

cgcgcgggca gcgagctggt cttccgggga gagcgtgaat gtctcctcgg gtttatcggc      600

aatgttgcgg cagggaataa agatttgttg ctggcctgac tgaacaatca ggccgcaggc      660

ttctttgggg tattcagcag cgacgtgctg acggatagca tccagcaatt tttcacgcat      720


<210> 1308
<211> 738
<212> DNA
<213> Escherichia coli

<400> 1308
ttatttcccc tgcaggtttg cagccggaaa accgccgaac ggcagcggcg catccgggcc       60

gtgacgatcc tgacaatcct gccggcggcc gccacaaaca tctttcgacg ggtcatcggt      120

cggtgtaccg tctttggtaa agtatttcgt gccgttgtaa tcgcatccgg tcccgcttcg      180

gtaccagccc cgcatacacc aggtgcagac aggcgtaatc tgccgtgtcg gcagctgcag      240

gctctgaata tcgaaaggag aacacagctc gaaatcaacc tgtacccgcg tctctgcggt      300

tttagcattg acgtaaaaga gctgtaagcg ctcatcggcc gggctggcac ccggattacc      360

gtttttccag ttggcggcat cgagatactt cgaaagcgtg gtatggattt tgaccttagc      420

cctgaccata tcgtcatatt caagacacag cgcggtgaca tagtttccga cgttcccgac      480

ggacagcgtg ggcgttggct gggaacctgt actcgataac tccatcccct taagttcgta      540

gggatgggga tcgtactggt ttccctgcca gataatggcg ggcagatttt ctgcggcgaa      600

ggctgcccac ccctcttcct gaatattgtg cgcatgaaaa cgcagcacct gatccatacc      660

gaattcagtg ccgtcgatct caatcagctg aataacgctg ccgggctcaa gctgttgtat      720

gtctgccgta aaactcat                                                    738


<210> 1309
<211> 339
<212> DNA
<213> Escherichia coli

<400> 1309
tcagggcgcg aacgcctgtt caaaagtgaa ggccacagtg gcttttttcc cggtagggaa       60

agaaacgctg aacgaatcgg ccttcattct gaacagcttt ttttcacccc atggagtggt      120

ccaccagaac gatttagtaa cgtgagacat caggaaagcg cgcagcgcag ccgcctcctg      180

tctggtgccc gtccagtcca ggttccacgt ttcctgtttg tcgttgatcc ccatccccgc      240

tatctgtttg tagccatccc cgaactgggc ctgcagcgtt cgggctgttt cagtgccctg      300

cgctgttttt cgcgtgcgcc aggtaaacgt gtccgtcac                             339


<210> 1310
<211> 3138
<212> DNA
<213> Escherichia coli

<400> 1310
tcactgtgtc ctcctcgaat aaagcacgcc gcccgcggac atttcttttt tcagtcgctc       60

ggtgattgtc tgctgaacaa tcgcctgcag ctgtttcgcc gtccccgtgg cgttcgcctg      120

atttatgctt ccgtcactcc cctgctggct gatgctgact ggggcataaa cactgatccc      180

gcccatgcca gcaccggctg cgttcccgcc gccgaccaga ccacccgagg catacccgcg      240

catcaggcga tagagattag ccacgccgat gcggctggtt gattctttgg tgaagacgaa      300

ttccccgcgg tgaacgatac cggctggctc gtacttgccg ccgtgcccgg taaaaccgcc      360

cacgtcaaaa ccctgtggcc ggtatgacgg gaccgcgaat gactgaccgg cagaggaggt      420

tttcgccccg ccgctaaccc agcccattgc actctggatg gtgtaagcca ccagcagctg      480

gttgataacg gacacaatca ttttaaggat cgagctggtg aattccctga agctcgcctt      540

cccggttgtc gtcaggctgg taagctggcc cgccaacccg ctgaacgtag cctgagaaat      600

ctgctgaacg gagctgaaaa cgtttgtcgc tgaatcctga tattcggccc aaccctgttt      660

cgcaccggcc agccagtttg cacgcagggc atcttcagct tcgaacgtcg ccctttgctc      720

ttccagaacc ttttgctgcg cctgagggtt gtacgaatag ctttcgctga gacgctgcag      780

cgtagtttgt cgcccggctt cccgggtgga taacccctca gactgagcct gcaggcccgc      840

cctggcggct ttttgctgct gctcaaactt cacggcctga tcggccagct ggttgagctt      900

ttgctggctg gcaaccttat cgcccaggtc ggccagctgc cgcttgtact cgagcgtttc      960

ttctttgtgc gccagcaggg atttttcctg cgccgtaagc tgacgacgcc cagcggcctc     1020

ctgcagaacg gtgaactgat tttcagtttg ccagagatcc tgacgctgtt tacttatgac     1080

gtcgttcacg ctggtatgct gctcaagcgt tttaagctgg gcctgaaggg tgagaagttc     1140

ggcctgcgcc ttttcctcgg ctttgtcccc ggcgggcgtt gagtagcttt tgcctttcgg     1200

tgtttttgga tccttccact gcttttcaat cccggcgcgg gccgcggcaa tgtccttttc     1260

agtccacagc gtggcgacac cgtctttcgc atcctggcgg tttttctcaa taagctgact     1320

gagctttttc tctgctgaag cccgcttttc tgccgccgtc gcgccggact ccaccagctg     1380

gttaaactgc tgctggctgc ggattgcctg agcctgctgg tccgttcgca ttttttcccg     1440

cgcggctgcc agcccttcct gggcgtattg ctgatcggca agatcgtaag cctgcttttt     1500

cagctccacc tgctggcgcg cgtttctcag cctttccgca tccgctttct gcagaacgtt     1560

gttaccggca taatccgggt cgaccttaag attgctggac agcgcgcggt actctttctc     1620

tgctgcctgc cactcagcaa aagagtcctg gcgcttcatc gcggtgtcag gattacgccc     1680

gacgcccagc atcgcatccc acgcaccgga ggcggcattc ttcacccagt tccaggcttt     1740

ttcgagggat ccgagattat cctcgaccgc accggcgcgc tgaatgaccg cgtcggaata     1800

tgcccgcatg gccagctcgg cagccttctg agaatccccc agcgcctgag cagaagctat     1860

ctgttcatac tgggtggctg tcagaaaatg aagggaatcg ttgagcgtcg cgaccgcgtt     1920

aaccggatca tccttcaggc gtttaaactg atttatggtt tcgtcaacgg cctgcccggt     1980

agcctgctgc agcctggcgg caacattgct gaccatgctg acgtcattac cgctgaacgc     2040

gccgctgcca acgacctgcg ccagcacgcc tgcagcggca tgctgagtga tgccattacc     2100

tgccagcgag cgcgccagcg cctgcagctg ccctgacgtt ttccccgcgt agttcccggt     2160

caggatcagc tgcctgttaa attcctcaga ctctttgctg ccgtcgtacc aggccttacc     2220

caacccgaat accgccgcgg caatccctcc gaccatgctg gcgatcccaa gaccgcgcag     2280

tgacagaagc tggtctatcc accctgcccg gttagccagc gtgatcccgg agccgcgcag     2340

cgcgccgaag ttaccgcgca tgacctcgcc gatcagtatt cccagttcct gccgggcggc     2400

ggcactttgc agccccagac cgtgcgtggc gactttggca gcttcgagct tgcggatata     2460

gacttcagcc gcatcgctgg caccgacctg cgccgccttc atgcgcagta gctcggtacc     2520

ggagagcttt tgctctgcaa cctgttgctt cagctggctg aggaatcgcg tgcgcgctgc     2580

ggccgatttt tcctccacga tctgcagttc tttttgacgg gccgtggtgc gggaaataag     2640

ggcgagataa tcctgctggg ttatgttgcc ctgtgccctc gctgcgcgaa agcgcgcctg     2700

cacgttcgca agcgactgtg tttcaccatt gagctggcgt acgccgtcga tctggcggaa     2760

aaatgatgcc gcaagttcat cctgtcgacg ggcaagcgca gcggcctgcc cgtcattctc     2820

acgcatgcgc tgattaagct cggtcacgcg gcggtgagtt tcatcaacgg actttgaaac     2880

gttctgccag tctttggtaa gcccttccgt tgcggccgac tggcgggatt tcatatctgc     2940

ggcagccgcc gcgccagcgt cacccacggt tttaaacgca gccgcctgcc gctctgaagc     3000

gcgctgcatt cgcgtctgga ctttttcaga gtcctcagcc atcccggtta gctggccctt     3060

tatgcgggca acctgctcac taaacgtggc gctgtcgacg tcaaggttga tgaccagatc     3120

gctaatctgc tgggccat                                                   3138


<210> 1311
<211> 273
<212> DNA
<213> Escherichia coli

<400> 1311
ctaatctgct gggccatatc ggatacctcc tgttatcccc tcagctgcgg ccatcagcgc       60

atcatcatcc ggctcgtcat cgctgatgac gataccggaa ggagaaagca ggctgaaatg      120

tgcgggggta agttccgggt cgcggaagaa aagagtggag atggaataaa gcagctctga      180

gaaatgcgca tcgagctgag cgtcctgaaa ataatgctcc cggtagaact ggtgccagtc      240

gcccagctca gtggaagtca ttccagccag cat                                   273


<210> 1312
<211> 432
<212> DNA
<213> Escherichia coli

<400> 1312
tcagctcgct ggcaagggct tttccgccgc aacgggttct gcgctttcgg cctccgctgg       60

ggcatccgga tcggcagctt tgtcatcctc aaccggaacg agcatgccgg agagcagctt      120

tatttccatt tctgctttac cgatcgcctc cggcggccag ccgctaagca cctgctggta      180

aagcgtctcc acatccgtgc cagccggatc gttatgccac aaagacatcg caatcaaacg      240

cgcaccgcag cgaatatttg agccaatcag cctggccgtc atttcctgat cgctgatgcc      300

gtcgctgtca gcgctgacgg ccttttcctc tgcggccata aacgtgatgt actcaatacg      360

ctgaagcgcc gacagctcga agatggtcag tgattctttt tgccaggtga acttctcttt      420

tttcagaaac at                                                          432


<210> 1313
<211> 744
<212> DNA
<213> Escherichia coli

<400> 1313
ttacgctgca gttacggtaa ctttgcagac cgcaacgaaa ttaccgtcgc tggtcataac       60

aataacgtca gcggtgcctg ccgccacgcc ggtgacggtg atcgcattac cgctaacggt      120

gaccgttgct tttgccccgt ctgaggttgc cacacggaac gaggtatctg aggcactggc      180

tgggttaacc gtcacattga gcgttgtggt tgcgccgacg gccacgcttg ccgtggcttt      240

atcgagcgta acgcctgtca cggggatatt cggggtcccg ctttcttctg ccagttccgg      300

cttgccggta ttggtaattt tcgctgtacg ggttatgacc tcttttgccg gaatggcttt      360

acccaggctg ctgcaccagc cgcggaaaac gtcgacggta ccgttcgggt atttgatttt      420

gtaatagcgt actgagccat caataaacca tgcgacaagg tctttttgcc cttcttcgcc      480

cggcttccag gcgagggtga acgaggtatc gccagcagat tttgccccct gggccgtcgc      540

gttccagtcg gcatcctcgt cgtcgaggta agtgtcgtca tacgattcgg cggtcatttc      600

gcccggcgtc agctctttaa ttttcgccag gcggttccag tcgatatccg agagtgggtt      660

agcgaaagcg ttgcccgttc cggtgtaaag ccagagggtg gtaccggcac ctttcacagg      720

ggccagcggg tttggagtag gcat                                             744


<210> 1314
<211> 402
<212> DNA
<213> Escherichia coli

<400> 1314
ttaaattgaa taggtgatta agtacgtgaa atcgactgaa ccccaggtgg ccatttcatc       60

atcccgctga tagtcataac cctgcggggt gaacgtctcg accagttcgg tcagacctgg      120

gatgaaggcc attgccggat acactttctc ttccatccag gaatcaagcg cgctgtcggg      180

gctggaggct ttaagaaata cctcgatgtg aacaaccgcc tgccacgaat cttcgtcaag      240

cgaatcgccg gtgtactccg cgtcagaaag gtatacagcc acggcaggga gatcctgctc      300

ttcaagaaaa acagggcgcc cgtcaaacca ggtgaccgtg tcggtgatct cggctttcag      360

tttggccaga atggctgcac gaattgcgct gtgtctgttc at                         402


<210> 1315
<211> 573
<212> DNA
<213> Escherichia coli

<400> 1315
tcatcgcttc aggtggatcc tcagttggtt tttcagggct gcggaaagtt ctttgggcat       60

atcgctttca ataaggcgct ttgaaatagc ggtgaaggcc acggtgagcg gtgtctcaag      120

aggaactttg accacatcaa tcggataacg ggcctgacct acgcgccgca tgacctgcca      180

gcgcccgttc gcaagctgtt ggataaaagc gttacgaaag gtatagggcc cgattttaag      240

gacgctgccc gctccgtttc tggccccttt tttacgcgag agcctgacgc gcgccgtgcc      300

gagctttatc gcaggaagat taccgcggtt gatttttatc gacgcgaccg ggcgatcgtg      360

acgggccttg cgcagacggg aacgctggcg gaccagacga accggaagcc cctttttccg      420

gttatcatca actgttgctt ctttcgctac agctttgctc ccctggctta tcgttcttct      480

ggccaccctg ttaagtgctt ttgcggttgc ctcaggaacg attaaccggc tgaggctgtt      540

caggttctga atagcccttt ccagtccttt cac                                   573


<210> 1316
<211> 243
<212> DNA
<213> Escherichia coli

<400> 1316
tcattcgaga tggatgcggg gttttccgtt gaacatgtca tagcgggtaa cgatcaggtt       60

cttaccgtcg tagtcgacgc tgtcgtttcg gcgtggctgg taaagctcag agaaaaccac      120

cagcgaagta cctgttcccg acaatggccc catttcctcg agttgctcgg cgggaacaac      180

gtcatagctg ctgccattga tgatcgctgt ctttcccatc ttttttatag tggccgcgtc      240

cat                                                                    243


<210> 1317
<211> 327
<212> DNA
<213> Escherichia coli

<400> 1317
ttaggcattg atcttaactt caacaacggt ggtgtttgcc cctgcatctt cccaggcgat       60

gcccgcggca acggcgtccg tttcttcgat cgtgattttg ccgtccttca gatacacctg      120

cgccccggca gtaaccgcat ctgcggatac ttttggcagg aggaaaacac cctcagtaaa      180

accgtccccg gtatcgccag ccgggatatc ggtaattgcc accgcgataa gttttccaac      240

aacaaccggg tcgccgctgt gaacatcggt tgcaccactg tttaccagag ggatcgtttt      300

cccgtcctgc gcatagttct tagccat                                          327


<210> 1318
<211> 1947
<212> DNA
<213> Escherichia coli

<400> 1318
ttactgacca gaggatttgg tcatgccgcg atagtccagc ggcgccacgc cagcatcaat       60

acgcactttc gtggcgatac catcagtggt gaagccttcc tgctgatcga tgtatggcgt      120

gtcgacgccg ttgagataag cgacctcaat ggtgtcggtg cccttcgcgg cagccagata      180

ccaggctttc gcatcagctt catccagacg tggttcggca atgacttctg caaagttctg      240

gatagggtta acgatcccgg cattgatgtc tgcaccttta acactggccg acttgatggt      300

ctgatttgcc agagtttcca gggcgacggg caccagcatg taggccggac ggatattcag      360

ggttcgctcc ccctccttct gcagacgcat cagcttgcgc gattcgtcca ggctggccac      420

agaaattgca cccgagctca ggttcttgtg atcggcatgg aacagcgcct ttccgtctga      480

gagtttcggg tttttggtca gaatggcgta aaccagatcg ccaatcgttg ctttcgccgc      540

gcgccccatc ttcatcggta cgtcggtaag ctggttcaga tcgtcgttga tgatcgcctg      600

gcgagttact gagaagattt caccatacgt ggcaagcgcg atggtttcgc ctttgtcact      660

ggtagtgatg tacttgtact cagccccttc gcgaacctgt cgcagagaag ggaacccacc      720

cataccgaca cgatgcgccg ttttgaagtc cgacagctgg ccttttttgg tccactgctc      780

gaaggtttcc tgcgcctcgt cccagccctg aatcagcgct ttgttcgcaa catcaagcag      840

aatgttgcca aagtcagagg tgctgtgggt cagcgccagg ccaaccatct gcatcgggtt      900

gtagctggcc acgccgatac ctttttctgt cagggccata cgcgcatact cgcgcagcgt      960

cataccgtta taaacgttat cccgctcctg accttcgaac ccggcacgcg ccatcagtgc     1020

ctggcgaata ccatccgcga cgaagttacc gttgcccgca tgaatatgcg gctgagtggt     1080

tttattggac ggcgtggccg ttttaccgag ttctgccagc agcaaatctt tcgccttatc     1140

gacggagcaa tcagggtcgg ccacacactg attctgcagt tccatgtgct tattaccgaa     1200

catggcaaag agatcgccga tagcgttaac acgggttttc tgctcagcca acacctgcgc     1260

gcggatcgca ttttcatccg gtgccgggtc tgtttttgcc tgcggtgcct gaggctgggt     1320

aataaccggg tcacgctggg tagtgttgcg cggcggggtg atcatgttgc gaatgctttt     1380

tggcattttt tcaaattcct caatacgttt tgaatgaata caggccatag cctgaaggga     1440

tggtgtcacc tggtcggcaa aacccagttc aaggcactcg ctgccgttca tccaggtttc     1500

gtcctccagc attaccgcaa tttcttcggt ggattttccg gttttctgtg cataagccgg     1560

gataagaacg gattcaacct tgtcgagaag atccgcatag tcgcgcatat cgctcgcgtc     1620

accaccagca aacccccagg gcttatggat catcatcatc gtgttttcag gcatgatgac     1680

cggattgcct accatcgcaa tcaccgaggc catggaggcc gccagaccgt cgatatgtac     1740

ggtaatcgcc gcgccgtggt gcttcagcgc gttataaata gcaattccgt cgaagacatc     1800

accaccgggc gagttgatat aaaggttgat gtgggtgacg tccccaagtg cccggagatc     1860

attgacgaac tgtttcgccg ttacgcccca gtacccgatt tcgtcataaa taaaaatgtc     1920

ggcctcactg ttattgctgg cctgcat                                         1947


<210> 1319
<211> 1500
<212> DNA
<213> Escherichia coli

<400> 1319
ttactttttg cgctggcttt cggacggtgg cgcgcccggt tctttggctt cggcactggt       60

gcctccttta tcattggcgg ggtcggtgtc aaacaccagg ccctgttcac ggttctcgtc      120

aacctcagct ttacggcgtg acttaacatc atccgggttg cgaccgctgg cacgtatcca      180

gtcggattca gtagcagcac cgccgcggat ctgcgttttc caggcattcg cttctttaac      240

gggatcaatc cacggcataa cgggccccga ataaaccgcg ttataaagcg agtccatatc      300

aatgcctctc ggcagcttga tttctccggc agcaatagcc atcttgagcc aggctcggta      360

catgggccgg gtcactgaac cgatgaacca gtcctgaaga atcagatagc cgtcggttga      420

ctcgacaagc tcctgccgct gggcactgta cgttccgttg tagtttctgg atgtgctgga      480

aaagctgagg cgactgccgg cggacacggc acgcagctgt ccgttacgaa aagattcgag      540

gttagggttc gggcgatcgg atttaatcat cccgatttct tccccggcct gcagttcgtc      600

atagagcata ccgggctgaa tcatcagctc gcggtcatcg ctgcttgaat cagaatcgaa      660

gctctgtccg tcgccttttt tgatatacat gccgagtgcc gcagcaattc tggcagcagt      720

aagctccgag tcctcgtatt ctttcagcgc gctcagacgc atcagaacac cagacaaaag      780

agacgttccg cgggtctggt gcaggcgtcg ggtgaatttg agatgcagca tgttctctgc      840

atctatctct ttggtatcaa actgacgccc ggatactggc aggcttttat agacctgata      900

ttttttcggg cgtccccagt tatcgacaaa aacgccctga ttgagctggg tggcagcatc      960

gctgttcatc ggcacaaagt ccggctccag cgcttccagc cagaacggca cgccagcaac     1020

cggctgaaga ccatttccgg taccgcgaac cagctgagca aatacctcac cgtcccggag     1080

ccacgttcgc agcatcagcc gctccagcat tgggcgggta aactgggttg tgacatctgg     1140

ccttacggac cattcgcccc actttcggcg gatatcagtg gccagctttt tagcgatctt     1200

cccgttactc agcatcggat gcggttcaac tatgatgccc ttcgcaccca ccaccctttc     1260

ttccagcttg tcgaaaacgc cgatcaccag atcgtggttg ttatccagcc agcgcgcctg     1320

ctgcctcagc gaaaccgccc ccatctggct gagctgatcg gctgaacgat tttccttctg     1380

ggctttgtgg gtacgcgttt gctttaccgc ctcatacgct ttaataactg cgcgggcacg     1440

caggcgtgag gctttccagc ctggtgaaaa caggccaatc gcatcatcta aaaaactcat     1500


<210> 1320
<211> 216
<212> DNA
<213> Escherichia coli

<400> 1320
tcatccaaac ctcgccagcc tgtagccggg tcgcccacgg cgtttgttat tgagcgttgc       60

cagtcgtcgc tcccattcct gacggccttt tctgatttcc gacaggtttt cgagcgtcat      120

ctgctgcccg ttgaaagtga ttgatttccc ctccagaaca gacagctcgg ctgcagcata      180

gcggtcgatc atgttttgaa tatctgctgg attcac                                216


<210> 1321
<211> 2103
<212> DNA
<213> Escherichia coli

<400> 1321
tcacacccaa cctcctgacg aagaccacgg attagcctgc tcggttacgg gcttctcacg       60

ttttggtttt ggtttagatt tcggcgcagg cggcggggat ggcatttcgc cagcttccgt      120

ctgcgtgtcc tcgatccacg tttcccgccg tgcccactca ggagctgacg gccatttgat      180

tttttcgtaa ccactaagga tggcgagcgc gtcggcataa acgagcaggt caaatgcttc      240

gtttgcgccc cggccgggct tactccattt cccttcattc gagcgttcct catacgtcag      300

ttcgtcatag aaccagctgc ccagccaggc ggggaaatgc acatagccag ggccgggtga      360

atcacgccac agcgcattat tcacccggtc tttaagggca tcggtctgga gaagataaag      420

aggcacatca ccagtcgcct gtgcgcggcg cgttgatctg cccgtgttgt cgggaaacgt      480

tcgctggata agtttgctgc gcctgacgct gtcccctttg aagagataga tacgcttacc      540

cagcccctca cggcgacatc tgcgccagaa cttgtaggca ttatccgtca cgccatcttc      600

gccccctgag tccacggcca tcgacatcag ccgcatgccc tttgatgggt cagctgcgag      660

cggccacgtt ttatcaaaga cgtcagtgag taaaagatcc cagtcctccg gatagctcgc      720

cggatccacc tgaatgcttt caccgttgcc gtcgcagcgc agcgaatgcc ggatgttgta      780

acggtcaact atccagcgct cacccatact tccataaccc gtaatctgca caacaaagcg      840

ccggttgcgc ccggcctgca cgtccacggt cgcagtgaga aactgcacgc cgttcggtac      900

cgaacgtttt gggacgtctt cggcacgctg ctcgagcaat tcacttttac gctgctccat      960

gctggctcgc ggcaaatagg gcctgccgaa atcggtgttg atcaccgtct tcagggtttc     1020

ttcgctgcgc gtggattcat attcctgctc ggcggtcaga aacttataaa taagctgcgc     1080

ccaggtctgg taagcagctg ccggaccttc catccagaag gaggcaatac gggaacgacg     1140

gccatcaccg ctaaccaggc ctttcctgtc gatggtttgc ccgtcccgga gccagacaca     1200

tttcatgtta agcgcacgct tcatgtccgg tgtgatcctg cctttacagg cagggcactg     1260

aagaaacgcc gcttcgctgg caagcacagg atcgctgctg tcgcggtatc cggtcatatt     1320

gtccatttcc ggctggaaat attcgccgca atgcgggcat ggccagtaaa gacgacggcg     1380

gtcaccacgg ttatagagcg ataaaattcc ggtggtcgga ggggcttcat ggggcgtgga     1440

gcgccgccat tttgtgtctc tgatatccct cccgggcgag ctctcaacca gcgtcatccc     1500

ggaggacatg aatgtcgtgg ttcgtttcga tgccagtgaa aaagcatccc cctccccgtc     1560

gatatcttcc ggaaagcggt cataatccgt cagcgccaca cttttatagt ccgaggacga     1620

catgatattg acggatggcc agcccagctt cagatagtta ccggcgcgga atgtacggtc     1680

gtagacgttg ttatcgttac gtcttgggct tagccgggtt ttaacttcag ggctacagcg     1740

aaaagtacgg tccaggcgtt ttttggaatg ctcgcgcgct ttttcctcag atacctgaat     1800

tacaagcata tctgccggat cgcagacaat gttataaacg atccagccgt caatcagccc     1860

gatggtttta cccgttcgcg ctgggcccac aaacacaacc gcatcgtatt cacgcgatgc     1920

cagacagttc atcggctcaa tcacataggg tgccagatcc ggatcccacg gaactgagtt     1980

tcccgccccc attggcacgc gcatataagt actgaccgca tcggccaccg gcatacgacg     2040

cggggctcgt aaaataccgg aaacatcgcg gcggatgtcc ctggcggatg cccgctttgc     2100

cat                                                                   2103


<210> 1322
<211> 489
<212> DNA
<213> Escherichia coli

<400> 1322
tcagtcctcc tcaggctgct cctcctcttt tccagcgtcc tgcaccttct ccgccatctg       60

gtcgcgcaga tcatcgataa cgctttgcac acgaactacc gcagcaggcg ttaaagcaca      120

gtcgcgctcg agcacatccg ggagggtttc aagtaccatg acgacggctt tcgccatcaa      180

tgagaattct cgcgccactt catctgcggg tattaactgc cccgtatcct gttcgaactt      240

cagcctctcg ttctctgctt tccagtggga cagcctgtca gaagggggca tatcgtcgat      300

gttggccgaa acggtaggga tcatcagttc ggtcagaatg tcggtcacca gatagagctt      360

taacttgcta ttgctgcctg gagcaggttc aacatttttc agtctcgcgg caaccgtctg      420

acggtgtacg ccggttatcc ctgccagctg gttgatattg agttttaaag tggcaatttc      480

ctggtccat                                                              489


<210> 1323
<211> 729
<212> DNA
<213> Escherichia coli

<400> 1323
ctatcgacgg cactgctgcc agataacacc accggggaaa cattccatca tgatggccgt       60

gcggacatag gaagccagtt catccatcgc tttcttgtct gctgccattt gctttgtgac      120

atccagcgcc gcacattcag cagcgttttt cagcgcgttt tcgatcaacg tttcaatgtt      180

ggtatcaaca ccaggtttaa ctttgaactt atcggcactg acggttacct tgttctgcgc      240

tggctcatca cgctggatac caaggctgat gttgtagata ttggtcaccg gctgaggtgt      300

ttcgattgcc gctgcgtgga tagcaccatt tgcgatagcg gcgtccttga tgaatgacac      360

tccattgcga ataagttcga aggagacggt gtcacgaatg cgctggtcca gctcgtcgat      420

tgccttttgt gcagcagagg tatcaatctc aacgccaagc gtcatcgaag cgcaatattg      480

ctgctcacca aaacgcgtat tgaccaggtg ttcaacggca aatttctgcc cttctgatgt      540

cagaaaggta aagtgatttt ctttctggta ttcagttgct gtgtgtctgg tttcagcaaa      600

accaagctcg cgcaattcgg ctgtgccaga tttagaaggc agatcaccag acagcaacgc      660

gccacggaaa aacagcgcat aaagcacttc attagcagcg ccagatagcg taatgatttt      720

gttactcat                                                              729


<210> 1324
<211> 231
<212> DNA
<213> Escherichia coli

<400> 1324
ctatttgtgg gtaaagttcg tagtgcgctg atcgtgcaaa atgattttag ttgggaacag       60

ttcgcaactc tgtcccataa aaatcagcat attcccatct atcccatatc cagcgcattg      120

accatcggga tactgaaggg agattccatc atctcttaga aagatcacca tctcttttgt      180

ttcaatttgc atatagctac ctggaggatt tatgaatgca aggattttca t               231


<210> 1325
<211> 597
<212> DNA
<213> Escherichia coli

<400> 1325
atggactatt accatgagat tgattttcca tctttattcg cgagagcagt ggaaagcgat       60

gacgatgtgg gtactacatt gcgcattcac ctactttgtg agcgcatggt cgaagcatgg      120

atatgcgcat gctgtgactg ccaagatctc tttggaagag ataaaaacaa acttttaatc      180

gaatgtaata ctaaaatatc catggcggga aacctgggaa tccccccgga acttatgaaa      240

tcacttaaaa ccatcaactc aatgcgtaat gaccttgcac acaatccatc aatacaaagc      300

attgctgatt caaggatcca gagcctgaag gatactctga ctgaatactt taaacagcat      360

ccaacggaac ccagcatgga agaatcaaaa ctgggtattt ttaacgccga gaatcaatta      420

accgaagaag tttccttaga tagtgacagt tcaaaaaaca gacttaagtt aatcttgctg      480

ttcagcaagt taatgcaggc gttaatgcaa ttagttgcag ctaatcataa tgggcgctgg      540

gataaccaat ttagccaatt cgtttaccat gtgaccatga acgcaacaaa gagataa         597


<210> 1326
<211> 198
<212> DNA
<213> Escherichia coli

<400> 1326
ctagtcgtcg agttgcaaca caccgtgatc cagtgattct gaataggcga taagtccggt       60

ataaccgggg ataatctcac cattatcagc ttcaaattca ggaattgtgc cggtggtgat      120

ggtgtattga ggctggccat cttccttcgc gaaggctgcc aggtcttcaa tctgcttagc      180

tgtaagaact actgtcat                                                    198


<210> 1327
<211> 480
<212> DNA
<213> Escherichia coli

<400> 1327
ctattggtta ttcgacagtc gcactgattc gtaaatccgc tcacacgtca ttcctgcccg       60

gtagctttcg tcagatcgtc cagcataata tcgagctgct tctgcaaggc ttccgagcat      120

gtcggcaagc attgctgcgt tggctccggc tgttttgctt ctgacggaag tggcgagatc      180

tgcggtgtgc tttgcggcgt ccatgtgggt agcgagtttt gttgcttcgg cgcgcagctg      240

cttaacagtg gtagccaggc cagcagaagt aacggcagcg ctcgctgctt gagcttgagc      300

atctttaacg gcctcatccc gggcgattgt tcgcccttgt tcaatcatac gagctgcggt      360

ctgtgcattc gcttcctgtg aagattccgc gctatcccgg tcagcccact ttattttcca      420

gctgcggttc gtccactcac tgccagcgag aaacgaacct accaacgcaa caatcacaat      480


<210> 1328
<211> 549
<212> DNA
<213> Escherichia coli

<400> 1328
tcactggtct atcccccagc acgtcagtgc gctttcctgg tcccgccgtt ctacctgccc       60

ataacatcca tccttctggc ccttggtcag gcggcaatcg cggccaccgt ctttaatcca      120

ccagcggata gcttcacagg ctcctttcgt atcgccagca ttaattcgct tatagaacgt      180

agacgggaaa cattttccgg ggccgatgtt atatgggcag aaagaagcga tacccgcttt      240

ctgtggttcg gtcagtggta ctttgatatt tcggtcaacc cacgccagcg ccttgtcgcg      300

ttcaatggcg tttacctggg cgcatttctc agctgacagc ttcatgccct gtactactgg      360

cttgccatca accattgttg caccacggca aatggtccag agtccgccgc cgtcgcgata      420

tgctgtcaag ctgttaccct ctttctcatc cagaaactga tcgagaatca cgggtgcgga      480

agccccggca agaatcaaac caacgaccgc tgcgctcaat ttattcttca gctttagaga      540

catagccat                                                              549


<210> 1329
<211> 279
<212> DNA
<213> Escherichia coli

<400> 1329
ttattcttca gctttagaga catagccatt gcgccgatcc tcccgttctt tccagcggaa       60

ataccagttc actgcacagg tgattaccgt gcatgcgata ccgacaataa ttgcccagtc      120

gctcaggctt aaccctgcaa ttctgtcggc caacatccag gacacctctt ttgctgtttt      180

agctgtttcg gcatatgcct tcgctgatac accgcagccg gcaagcgtgg ttcctgatcc      240

atatgaaagt ctgctgtaaa tggtgctcat tctggtcat                             279


<210> 1330
<211> 1053
<212> DNA
<213> Escherichia coli

<400> 1330
ttatgatttt ttcagttttt ccacctcttc ggtggtctgt ataaacctgt ctgcctccag       60

ttctacgccg atcgcccgac ggccaagttc tattgcagct ttcacagttg aaccagagcc      120

cataaagaaa tcggcaacga tatcccccgg tctgctgctg gcgctaatga tctgtttcag      180

catgtcggca ggtttttcgc atggatgttt gcctggataa aactgaacag gcttatgtgt      240

ccatacgtcg gtataaggaa caagagcgga aacagagaag cagcgccgaa ggattttgta      300

ttcctccagc aattctgaat acttgcggtt taatgactgg taggtagcca ccagctggtg      360

gtgaggatgt tcaagctttt gctgaatatg tttatcgatg gcgatccgcg tgaacagttc      420

ctgcaatttt cgatagtcca cttcattcgg tagttgccat tggcttgcac caaaccagtg      480

tgacgccatg tttttctttc cggttgcctc agctatttct ttcgagctga cacccagtga      540

ttcacgggca ttacggaagt aatcaatcag cggcgtcata atgtgctgct ttagctctgt      600

gcttttcctt tcgtaaacat cctctttacc tgtatacggt ccaagatagt gctcagcaaa      660

caaaatccgt tccgtagatg gaaagtacgc acgcaggctt tctttattac atccattcca      720

gcggcccgat ggttttgccc aaatgatgtg attcaaaacg ttgaatcggg cgcgcatcat      780

aatctctata tctgaggcca gtcggtgacc gcaaaacagg tagatgctgc cagcaggttt      840

aagaacgcga gcatactcag ccaggcagct atcaagccag cgtaagtagt cctcgtcccc      900

cttccattgg ttgtcccagc cgttgggctt cactttgaag tacggaggat ccgtaactat      960

aagatcaata gagttatccg ggagggtggc gacgtaatgc agactatcag cgttgattaa     1020

ctcaacactg tttattttta cagtattttt cat                                  1053


<210> 1331
<211> 192
<212> DNA
<213> Escherichia coli

<400> 1331
ttactggagg cgtttataac atccgaactg gtaatcagat aaccccgcca tcaccagctg       60

cgtaagtatg agctggcaac gttcgtggct gaggtgggta ttctgtgcaa tctccccagc      120

cgttgctggt ttatcgctta attcattgaa aacagccttt gccgtttctg tcatatcttc      180

ctgatttagc at                                                          192


<210> 1332
<211> 900
<212> DNA
<213> Escherichia coli

<400> 1332
ttagcaaata ttccacatca tcgtactacc gttatggttt tcgataattt ttgcggctgg       60

gctagtacca aaagagtgca tatagcaatg atgaatagta aggaccagat cctgcaacgt      120

ttggtcactc tctagctcca tgatatttaa accaatattt tgagctttgt ccaaatgaat      180

atgtctggca tgtgcatacg ttgcttggtg gttgtttaac tcatcacata tacgcttagc      240

cttagcttca gcgtcagcct gacctgcgaa cataccagta caaagccatt tctggacaat      300

ttcgttcgcc cagagaattg ctttttcaca ctcgccaatc aacgttggat ttagtttttg      360

gaacgtaaat tgccaccatt gcagtgcagc agggttggca aaaatttccg cttttgctct      420

ctcatactcc tcaataattg catgagatga taacccatta aactgtggat caattggccc      480

caagttcgac tgtttaccta aaacgatctg ctcagcacaa caagcaagca ttgtgccaca      540

actcattgaa atcataggta caatcgctcg gatattggtt ccgaactttg aacgaagata      600

atgaccaatt gattctagag ctgcgatatc gcctccagga gtatggagta agatatccaa      660

tcccagactc gtatctaacc cattgatagc agacataaga ccatttttat catcatctga      720

catctggatc agatgttgaa acccaggccc ccctttttga aggaagcctg agtaataaga      780

aattacattt cggccagtat gtttcgataa atcacgtaag tacttgtggc gaacctcatc      840

cgctggtgta cgttgagcga tagtacccat ctcacccaat acgtctatcc aatttggcat      900


<210> 1333
<211> 207
<212> DNA
<213> Escherichia coli

<400> 1333
tcagtatgag tacagttggt gagattgctg accgttctgc tcagtagtat ttggtgttac       60

tgtgctgtat gaatagagca caccacttct cacattcaga tcgttttgct gagcgagaac      120

acgcatagca aaatgctgta cggattcgcc tttttgaaac tcttggggtt gtatgcccat      180

tttttcgtaa aattcagcag cgctcat                                          207


<210> 1334
<211> 690
<212> DNA
<213> Escherichia coli

<400> 1334
tcacatttct gccactttga gggcttcttc ttcctcatag tattcaagag ccatggccaa       60

cgcagattca tcaagctggg taaaagcggc ctttaaccca gcccagtgcc ctgaatagac      120

acgcaaccat gtcgaacggt caacgctaac catgcgggcc aacgctgcac cagcatagtc      180

tttataggtt tcattatttc tggttgcggc aatttcctgc cctgccagcc ataccaggcc      240

tatcagtttc tttactacgc gctcctgaag ggagttatca cccaggcatt tctgataagt      300

tttccagacg tattcacaca tcatcacctg gtgcttatag ctaaggtcaa aaccgtagca      360

gtaccgcaac caggcctgct ggtatccact aagcgcggac actgccctac gccacggcgc      420

ggactcaaat tccgcatctt ttatcggcgg cattggcctg cggcggctgc gtgtttccag      480

cacatacagt ggcgcggaaa gtgagttaac aaagcgtggc cccttctctc cttcgagttc      540

gacgagatga attccacggc gaggggtggc atttttgtct gctggtgggt gttcactgaa      600

agcctcaagc tgcccttttg ttcccccaga caggtcaggt agcgcgcggc gcaattctat      660

tcttacaaaa ttcaggtctt gttgattcat                                       690


<210> 1335
<211> 996
<212> DNA
<213> Escherichia coli

<400> 1335
ttaagctttc gcaattacgc cgatcgccag cgcccgatcc ataaaacgca gtagcagctc       60

aagctgcgta ccatgcttct gctcgaatgc cggtacatcg gcgtgtaact cgtcgtggca      120

ctctctgcac agagggatca cgaagagatc atgggctttt gttgctgtcc cccccatacc      180

gtgccctacg atatggtgcg gatcatctgc tggccgtcgg caacactcac agggttgtgt      240

tttaacccag cgggtgtacg tctcatttat ccagcggcgt cgctttggcc tgagcatgaa      300

agattctgga gactccggat caacagagag cgtgaggatc ttcttcgcct tctcctgcac      360

gaggctggtt gcagaagcgg aaggcacaat gtcgctttcc ctcatgaccg agcggatctt      420

atcatccgga aggcgtagcc ccttgtgcgc aacgctttcc ggaataacat cagccaggtc      480

gtttctgacc atccaccagc acagttccgg aagcgtcagg atatgcgact cgggaaaacc      540

agaatcacgc cgaatgactt ccagaatcca ggataccagg tttcctgccg ctatacctgc      600

aagctgttcg gtatgctgcc ccgacaaagt gtgatcgcaa tgccagcaca ggcgaatact      660

tcctggtggg tgccgcattg ttgtgaagtt cttgtcgtgc cacgatgaat gtggccactg      720

gcattcaaac cgattactca accattgctc aagggaagga agcccaccag cacgctgaat      780

aacccgatca ttctcgaaga cctgccgcat taccggatca tcagccagcg gctgaatggc      840

ggcgggaaca gctcctgtac tgaatgacgc catttcttct ggttcaggct caagcagaac      900

gcgaccgcgc ataaagaggt gcatcagttc cgcgccggga cgaaacaaca caatccccat      960

acgatgggcg atctcggggg taagcagagc tctcac                                996


<210> 1336
<211> 684
<212> DNA
<213> Escherichia coli

<400> 1336
tcacgcgacc tgccccctgg caatgtgttc tgcccacagt ccaccaatcc agcgcacgcc       60

tttcgccgtg aaacgtgcct ggctgaatgc atgatttgag gttacggatg tgccggtttt      120

cacttcaaaa cggcccgcat caatatgctg atgccgtggg gtcatcgttc cgccaagacg      180

atacatgatg tcgttctcaa ggaggaataa ccgcagatcg ggctctttgg ccttaagcag      240

ttttgccacc tggcggaatg acattgaccc actggctgta cagtaccgat caacaaacgc      300

taccttcggc gccgcggcag ccagttcgtt agtcaactgc tgtttttgtt ctgcaaggtc      360

agctgcaaga cgtagggctt cagagaatga ttgaggaatc gtctgctgct gtgcctgctc      420

aagctcctgc cagcgatcaa ccagacgcgc ggtaaactcc ggcgacagct gcgcgacaac      480

gatataactg tcccgcttcc ctatcagata aaccgatacc gactgattga ggtgattttt      540

aacttccccc attgggggga gttcaataac accgcgctct gccaggcgtt caatggaccg      600

tttaacatgg tcatgtcttg attccaccag ctcagcaata tcgctgctgg acatggttaa      660

cgctgttgtt gctaactggc tcat                                             684


<210> 1337
<211> 387
<212> DNA
<213> Escherichia coli

<400> 1337
tcaggcggct gcacccgccg gttcatatct gctgattgtt atctctaccc gacctttcgg       60

cacaacgggt ccccattcca ccagcatgcg cttaatctgg ctgtcgtctt cccagacacc      120

cgcatgcgtc agcgcgtcaa acagggcttt gttgtaatta tcgatatccc ggcggcgcgc      180

atccggcggg tacagagtga tttctaccgc tgccagttca gtcgatggct tcgggagacg      240

tcgtaattgc tcaatgatcg ccacgcaggc agcgctctgg tatttacggc cagcggcgct      300

aatgaggtga cgaccggcca gcggcccctt gttaggggcg cgccagtaag tgttcacgct      360

cggaggaaaa ggcaggatca gtttcac                                          387


<210> 1338
<211> 1320
<212> DNA
<213> Escherichia coli

<400> 1338
tcacgcggcc tctccccgca tattgcgaac aagttcagaa gcagcagtaa tgatttcgct       60

ggtggcagtc cgctccagcc agagttgatt gatattggct ttcagcttgt gttgcagtga      120

ctcatccagc atgtcagcac catccacctg gtcgaataca attctaacct ccagcggcca      180

gatacgggac tcgggaagcg gatccgatac tggtttagct ttctcacgaa tgtgcatgcg      240

gatctggcga atattggacc aactggaaac atccaggctt cccatggctg caatgaagtc      300

agtgctgttc atgccatatt caccggatgc ttcaagggca acagtgcgaa tacgttccga      360

catatccagg cgcacagcag cgtcatcgaa ttcaatcgac aacagccact catccacacc      420

gaacaaaata ctctcacgaa taagcagctt cgctttgtcg atcgttaaag gtgatacctg      480

agtgaattcc ggtgcttcga cagaatccgc cgcccaggta tgcccaaact tcgattcact      540

gaatgtgtat tcttctttat cgccaaacgc agctctaacg catgcccacg cctcgacacc      600

gctgatagca aaaatatctt tctgggtgag tggcaactct gcttctggct tatcagctgc      660

aggaggtgtg gcagttacag gttgagactt gctggcagca aattgtgcca aagccataaa      720

cgcccgccct tttgcctcca gttctgtgcg gttgatatag ctgaaccgct cgccacgcca      780

tgacttatcg aatacagcta tggcaccggc aaaaaacgcg ctggtgggtt tctgtttttc      840

gtcagcaggt acaaaccaca caggcagatc gaacccaatg cgcccgcgaa tgaatacaat      900

gtgatcggca tcttccggcc accacgtttc actcggcgcg gcttttatca ggaatacata      960

gcgaccgccc ttctcgcgct gggctgctgc gtagttcatg atgtgcgtca tgccggtgat     1020

cgcctgcttc tcgtggtact gcgaacggct atacggtggg ttgccatagc cagcgccacc     1080

cagttcagcc agacgttcag accagtcctg cgtcagcgcg ttatcttcgg cggtgtacca     1140

tgccgggcat ttcgcgttgt cgtcgtcagc aaacaaatcc agaactaatg gaccaaatag     1200

cgcgttgatc ccccaaaaaa gcagatccgg tgtccgccac tgatcgccaa cctctttcaa     1260

ttcgtgagct ggtttgctac gcagtgccgc cagcgcctgg caatatttat tggtcatcat     1320


<210> 1339
<211> 882
<212> DNA
<213> Escherichia coli

<400> 1339
tcatgaacgg aaccccgaat tttctggcag tgagtaatca acactctgga agtttgcgcg       60

gctggctgag ttagtctccc atttgccgtt aacgcgttca ggccggccag cactggacca      120

tttggtcgcg ctttgcaggt aaccagggaa gttttttgga atgaacagag ttgccgggcg      180

gaggtattgc gcctgctcgc tatcacgcca atcggcattt ttgtaatcca ctaccaagca      240

caggtcatca acagtgaatt gttcccgaag acgggcgcga atattctcca gcgacgtgct      300

gcatacctgg tagcgtgagc cagtagtctg attcaggtaa gacaaaacct gtctggcctg      360

atcagtaatc acaacctcag ggtcgggttg cgccgcaacc ggacaagagg gttttgaagt      420

tacttgtggt tcttgttttg attttactga cggatcccca ccagattctg acgggtcaaa      480

accgcctttt ttgctggatt tcgacgcctc aaattttgac gggtcggatt ttgatgcatc      540

agattttgat gggtcagatt ttgatgcgtc agattctgac aggtgagaaa aagcagcctc      600

tcgcaactta acgacgttaa gctgatatac gttcgatgcg ttacggttcc cattacggcg      660

ctgcttacgg gaaagccagc catccttctc aagctgagca agggccgtcc ttaccgtact      720

ttctccagca ccgatttgac gtgcgatcgt gccaatagac ggccagctaa caccctcatc      780

actactgaag tcggccagac gcgccatgat ggcaacgctg gataacttca tgcctgacga      840

agcgcatgca tcccatacgt aaccggttaa tttagtgctc at                         882


<210> 1340
<211> 339
<212> DNA
<213> Escherichia coli

<400> 1340
ttaattctgt aaatttacgc tggaattgtt caagagggct gaagcactca tgatcgtacc       60

cttcgcgaag gtatataacg cgctgtgtat ctggctccca gcggacaact ctgacgggaa      120

ctccgtagtg atctctgaac cgccggttaa cttcagccat tcctcgcgcc ccttctcgtt      180

catctgaaca aatgcttcta ccatcaagtc tgctggctgg tagttgcctc catcagccgc      240

gttatttatg atttccacat agccgaactg ggcatcttta cccaccagcg gcaaacatct      300

gaattgctta gctggtctga atcggtttac actgttcat                             339


<210> 1341
<211> 564
<212> DNA
<213> Escherichia coli

<400> 1341
tcatgcgtta gtttctccac tgatacgaca cgccaaggcg cccggagctg cacactcgcg       60

ggcgtcacct tttctgcctg ttgaaacgaa tacgtcaatc gcctgatctg aaacaccaac      120

cccataaagc gccataaatc ccaggaaccc gtgaatctgg tggcggagct tcttactgaa      180

taattctgaa agcattttgc gctctgatga atcaattacc ccatcagccg ctgctgccat      240

cttggcatta gccagctcac cagatgctgc tgccgctttc atctcaatgc tgtacagctc      300

aacgttatcc aggctctcag cagttggaac atccaccagc catttccctt ttcggttcgc      360

ctggtactcg gccaagtaac aagaaccaga caggtcctcc atccgttcca gttctgccaa      420

ggtaaagaac cgactgccac acttctggta caggtggttg tggaactggt cgatagtcat      480

ccctaaatcg gaagccatac ctaagcgacc atgcttgtgt gccttacaca tcaggcggat      540

tgctgtattt atgctgtcta ccat                                             564


<210> 1342
<211> 258
<212> DNA
<213> Escherichia coli

<400> 1342
ttaaagttga ctattgttgt tagcggaagg tatgccgtca tttttgttcg gataaatatc       60

aggtcgtaat tgatggggag ttactaccca tccgccccat tggcagagtt gaataactct      120

ttcagaaggt actcggttct ttgcaatcca gttcgcaaca gattgaactg attggaattc      180

aaaccgcctt gatacctctg aaatcgaccc gatcgccttc acagctttag ctgttacatt      240

cttgtgttga gatgacat                                                    258


<210> 1343
<211> 711
<212> DNA
<213> Escherichia coli

<400> 1343
atgccttgtg cgcttaatct tctacttatg gtggaaaatg ctaaatacaa agactttgcc       60

gaaaggctaa acaggtctct ccaagagcaa tctattggag ttaaagaatt gtcagagttc      120

agtggtgtct cgtatgagat ggcgcggcgc tacactcttg gtactgcaaa gccgagagat      180

gagaagatga ttcgaattgc agaaagactt gccgtctcac cggcttatct tgattatggt      240

gtgcctgtta atggtggcga cgcgccagcc aaaggcacgg tcagaataga gcaattggat      300

gttcatgctt cagccggttc cggatatata aaccaaccat tccctacaat agtgagctca      360

atagagattc cagaagagag gatcttcgag ttgtttggtc gtagaagcct tgatggcatc      420

gtcatgataa atgttgatgg cgatagcatg atgcccacgc tttgcccaaa ggacctgctt      480

ttcatagaca gcaaggttga acaattcagc ggcgacggcg tttatgtgtt caattttgaa      540

gacagtacgt tcgttaaacg tttgcagaag gtaaaagggc gccgactggc agttctttca      600

gacaatgaac attacccgcc cttcttcata gaggagcatg aaatgaatga actatacata      660

ttcggcaagc taatcagatg cttacctcta aaaatgatag agtttggcta a               711


<210> 1344
<211> 198
<212> DNA
<213> Escherichia coli

<400> 1344
ctatttaaag agcttcttca gcttgtcctc aaccttcctg atttcggaag taagctggct       60

gctgttgaca ttgatagtag ctccacatcg acaagtgaaa cttttgttcg acttgagcca      120

agcgattttc ttcttcgtct tagtgccgca cttagggcat gcgggtaacg taatttcctg      180

gttatcaaaa gcgcccat                                                    198


<210> 1345
<211> 918
<212> DNA
<213> Escherichia coli

<400> 1345
atgaataatc cgtttttcaa aaatatgttg gtgtatcgca ttagtcgcga tttcaccatc       60

aaccaggaag agctggaaca gcagcttgaa ctatttcgct tcactccatg cggtagccag      120

gatatggcaa aaaccggttg ggtatcacca cttggtcagc tgtcagatcg cttgcatcac      180

actgtcaata atcaagtgtt gttggttatt cgccgggaag aaaaaatact gccatctcct      240

gtcattactg aagaactgcg caagcgtgtg tcgcgtctag aatccgatca ggggcgtcgc      300

ctcaaaaaaa ctgagaaaga ttcgctgcgt gatgaagtgt tgcactccct gcttcctcgg      360

gcgttctcca aaaactcgac tgttggtttg tggatcaacg tcaccgacgg tctgatcatg      420

gttgatgcag ccagcgctaa acgtgccgaa gactcactgg ccctgcttcg taaaactctc      480

ggttctctcc cggtggtacc gctgactatg gaaacgccga tcgaactaac tatgaccgac      540

tgggttcgtt ccggtagtgc gcctgctggc tttggcctgg gtgatgaagc cgaactgaaa      600

gctattcttg aagatggcgg tattggacgc tttaaaaaac agactctggt cagtgacgaa      660

attcatgtgc atctggaagc tggcaaagta gttacaaagc tgtctatcga ctggcaacag      720

cgcattcagt tcgttctttg cgatgacggc agcatcaaac gccttaagtt ctctaatgag      780

attacagaac aaaacgacga tatcgaccgt gaggatgcgg ctcagcggtt cgacgctgac      840

tttgttctga tgaccggcga gcttatctct ctcattaacg gattaacaac ctctctcggc      900

ggcgaagcca agcgataa                                                    918


<210> 1346
<211> 540
<212> DNA
<213> Escherichia coli

<400> 1346
atgagctaca ttcagacatt atccggcaaa cattttaatt acctcgatat ccaacaggac       60

gatatcgtga tcgaggatat tgctaccgcg ttgtctcata tctgccgctt tgcagggcat      120

cttcctgagt tttacagtgt cggccagcat agcgttttaa ccagccacct cgttccgcag      180

gagtttgcat tagaagcact gcttcatgat gctgctgaag cctacctgca ggacatcccc      240

tccccactta agcgcctgct tccggattac caggcaatcg aagctcgtgt ggacgcagcc      300

attcggcaga agttcggtct accaactgag caacacccaa ccgtgaaata tgccgacctg      360

gtgatgctcg ccagcgaacg ccgcgatttt gagattgacg aaggttccat ttggccatgc      420

ctcgagggag ttgtcccaac ggatttattc attatcaacc cagttcgtcc tggccagtca      480

tacggcatgt tcatcaatcg ctttaacgag ttgatggagc agcgccaatg cgccgcatga      540


<210> 1347
<211> 255
<212> DNA
<213> Escherichia coli

<400> 1347
atgaccgtat ttgaatatct ccaggctcat ccgaatacca ccagcggtga aatcgccaaa       60

ggtatgaaca aaaagacccc agcggtcgcc ggagcattat ctcagctcta tggcaccggt      120

cggatcgtga agtctggtgt tcgcaagggt attccaacat accgcattaa cgatatgccg      180

tttggttgca gtaacagcct aaccatgatg tttaaccagc tcttgagcag agccagacaa      240

ggagcagccc aatga                                                       255


<210> 1348
<211> 348
<212> DNA
<213> Escherichia coli

<400> 1348
atgacagcac tcaacaaaca ggcgctgcgt gaagaattcc agttcatgca ggacaactat       60

agcgacccgg cagaccacga tcggcaggtg atttacatcg aggcggaggc gctgctggat      120

gagttggaag ccaaagactc aacgatagca gcacaacaac atgagatccg tatgttgctg      180

aatgcgcttg aggaaaaacc atgcccgaaa tgcaacgaca caggaatgac tgatagtggc      240

ggcacgcagc catggggcga gccgattgag attgaatgcg actgccgaca gcaggatgcc      300

aacaccgcag aacttgtagc cgctggcatt ggcgtgaagg gggagtga                   348


<210> 1349
<211> 309
<212> DNA
<213> Escherichia coli

<400> 1349
atggataaat taatcaaacc taccgccaaa ggtaaatatg acggttcatg tgattatctt       60

tgctcggaag atgcgcgatt catcgttatg cgcggcgatt atacggaagc ggaaataatt      120

caggcttctg tgtctcaaga tgtaatcgac tcggatggtg cggctgattt tgcaagtagc      180

gcccgctatt atcagtgctg gtacaaagtt agcccaatag gtggtcagga tggctattca      240

ggctggcatc atcctcgtga ttcgccgtgt cgcggtgcat atttcgcatc agttttgcaa      300

tgggattaa                                                              309


<210> 1350
<211> 468
<212> DNA
<213> Escherichia coli

<400> 1350
atgacaacta acaaccaccc ggcgcacggt cctgtatcac tcgatcgcct gcaccagata       60

cgcgaacacc tgctgcatga tacccaatac tcaaacggcg ggaacagagc ctacattctc      120

gctgatgtat tgaaggtgat tgatggggct attgcccgcg agctggtacg ccgtgagcat      180

gcagcgtggt cacaggctac tttcggcgat gtcggtccag ttggtccgct gaagcacctt      240

tccaaagaag cgctcgaggc tgctgctgaa ccaggcgacc ttagcgaatg ggctgacatg      300

caattcctgt tatgggatgc gcaacgtcgt gccggtatca gtgatgagca gattacccag      360

gcaatgataa aaaagctggc tataaataag gttcgccaat ggcctgagcc gaaagacggg      420

gaacctcgat tgcatatcaa agaacagtca gagcaggaga aaaaataa                   468


<210> 1351
<211> 255
<212> DNA
<213> Escherichia coli

<400> 1351
atgtttagcc tgattcggcg cggtcaaatc tacacggaca gtagcaactg gcccgtaatt       60

atccatagct gtagtgatca ctcggtccga attaaacgca atgatggcga gctgagaacg      120

attagcatca aacgctttaa cgaagatttt gaacgagtgg agcatgatga gtatcgcaaa      180

atatgtgccg aaatagagca ggaaacaaac ctgaaaaacc tacgtgcgat gcgtcgcggc      240

aagattactg aatag                                                       255


<210> 1352
<211> 570
<212> DNA
<213> Escherichia coli

<400> 1352
gtgaacaact taatgatcga ccttgagtcc atgggcaaaa aaccgaatgc ccctattgtc       60

tccattggtg ccgtattctt cgatccgcaa agcggtgaac tgggtcagga gttttacacc      120

gctgttaatc ttgaaagcgc tatggagcag ggagcggtgc cggatggtga cactattctg      180

tggtggttaa gacaaagctc agaagcacga tcagcaatct gtgttgatga tgcgatgccg      240

atatcatctg ccctatctga actgagccat ttcattaatc ggcattctga taaccctaaa      300

tatttaaaag tttggggcaa tggagctact ttcgacaacg ttatattgcg cggcgcatat      360

gagcgtgccg gccaggtttg cccgtggcaa ttttggaatg atcacgacgt cagaaccatc      420

gtcacattag gcagatctgt aggtttcgat cctaagcgtg atatgccatt tgatggggtt      480

gcacataacg cactggctga tgcccgccac caggcgaaat atgtttcagc gatttggcag      540

aaactaatcc caaccaccag caacagctaa                                       570


<210> 1353
<211> 237
<212> DNA
<213> Escherichia coli

<400> 1353
atgagcaata ttttccagtt agctcccaac gattgggttt gtgaaagcgt tttgatcgcg       60

gttactgggc tcaaacccgg aaccatcctc cgtgccagaa aagaatgctg gatgattggg      120

agggagtata tccacgtatc gcctgacgga aatcctaaac cttccagtga gtgcatgtat      180

aacagaaagg ctgtagatgc ctgggtcgct tcaatgaaaa gcaagcaacc agggtga         237


<210> 1354
<211> 1314
<212> DNA
<213> Escherichia coli

<400> 1354
atggataaag tcacatatcc aacaggcgtc gaaaaccacg gtggcacatt acgcatctgg       60

tttaatttta aaggtaagcg tgtcagggaa agtctcggtg tccctgacac cgctaagaac      120

aggaagatag ccggggaact gcggacatca gtatgttttg ccatccgcac aggaaccttt      180

gattatgcaa cccagtttcc tgactcccct aacctcaagg cttttggtgt aagtaaaaaa      240

gacattacag tgaaagaact tgaagaaaaa tggctggatc tgaaacggat ggaaatctgc      300

gcgaacgcat ttaatcgcta tgaatctgtc gcaaggaata tggtgccgag gatcggaggt      360

aatcgcctgg tgtcagcagt aaccaaagag gaattgctgt atctgaggaa atatttgcta      420

actggttatc agaatccgac gaaaaacaaa gccccggcaa aagggcgaag cgttgttact      480

gtgaactatt acatgacgac aatggccgga atgtttcagt ttgctgcgga tcacggttac      540

ttagaggtga acccattcga gggaattaag cctctgaaaa aagccagggc agaaccagat      600

cctctgtctc gtgatgaatt tattcgcctg atagatgcat gccggcatca gcagacgaaa      660

aacctgtggt cattagcagt gtacacagga atgcgtcacg gggaactggt ctccctggcc      720

tgggaagata tcgacctgaa ggctggaaca attaccgtca gacgtaatta tacgaaactt      780

ggtgagttca ctctaccgaa aaccgaggca agcacagatc gagtggtgca tcttatccag      840

cccgcaatca gtatcctgaa aaatcaggct gaaatgacaa ggctgggcag gcaatatcac      900

attgaagtgc agttacgtga gtacggccgt tcggtgaacc atgagtgtac attcgtcttt      960

aatccgcatg tggtcagacg cagtaagcag gtcggattta tctaccgggt cgattcagta     1020

ggcgactcat gggaagcggc acttaagcgt gcggggatca gacacagaaa ggcgtaccag     1080

tcacgacaca cctatgcgtg ctggtcatta tcagctggtg caaaccctag ttttattgcc     1140

agtcagatgg ggcatgcgag cgcgcagatg gtgttcaatg tttacggtgc atggatggct     1200

gacagcagcg cagagcagat cgcaatgctg aatcagaagc tggcagattt tgccccattg     1260

atgccccata gccacgagaa cagtacggga ggattattaa aatcagtaag ttaa           1314


<210> 1355
<211> 726
<212> DNA
<213> Escherichia coli

<400> 1355
gtggagggta acaccacgct ttatgccctg ccgaaacccg aggttgtcct gcgctggcgt       60

gagcagacca cagatgactt ccgcttctgt tttaagtttc cggcgaccat ttcgcatcag      120

gcagcattac ggcattgcga tgatttagtg actgaatttt tgacccgcat gtcaccgttg      180

gctccgcgca ttggacaata ctggctgcaa ctgcctgcca cattcggccc acgggagctg      240

cctgcgcttt ggcattttct cgattctctt cccggtgaat ttaattatgg ggtggaagtc      300

cgccatccac agtttttcgc caaaggggaa gaggaacaaa cgcttaatcg cggtttacat      360

cagcgcggcg ttaatcgggt gattttagac agccgcccgg ttcatgcagc acgtccatac      420

agtgaagcta ttcgcgacgc tcaacgaaaa aaacctaaag ttccggtaca tgctgtactg      480

acggcgaaaa atccactgat ccgttttatc ggtagtgatg atatgacgca aaaccgggaa      540

ttatttcagg tctggttaca aaaattagcg cagtggcatc agaccactac gccttatctt      600

tttttacata cgccagatat tgcccaggcc ccggaactgg tacataccct gtgggaagac      660

ttacgtaaaa cgcttccaga gatcggagca gttccggcta ttccacagca atcttctctt      720

ttctga                                                                 726


<210> 1356
<211> 396
<212> DNA
<213> Escherichia coli

<400> 1356
atggtaagcg cgctgtatgc cgttttaagt gcgttgttat taatgaagtt ctcttttgat       60

gtcgttcgcc tgcgaatgca gtaccgcgtt gcctatggcg acggcggttt tagcgaactg      120

caaagcgcta ttcgcattca tggtaacgcg gtggaatata ttcctatcgc gattgtgttg      180

atgctgttta tggaaatgaa tggcgcagaa acctggatgg tgcatatttg cggcatcgtt      240

ttgcttgctg gtcgtctgat gcattattac ggttttcatc accgtctgtt ccgctggcga      300

cgttctggca tgagcgccac ctggtgtgcg ctgttgctga tggtgctggc gaatctttgg      360

tatatgccct gggagttggt tttctccctg cgttag                                396


<210> 1357
<211> 744
<212> DNA
<213> Escherichia coli

<400> 1357
atgtctcacc gcgacacgct attttctgcc cctatcgcca gactgggcga ctggaccttt       60

gatgaacggg tagctgaagt cttcccggat atgatccagc gttccgttcc cggctattcc      120

aatattattt ccatgattgg tatgttagcc gagcgcttcg ttcaacctgg tacgcaggtt      180

tacgatctgg gttgttctct gggcgcggcg acgctctcgg tgcgtcgcaa cattcatcat      240

gataattgca aaattattgc catcgacaac tccccggcga tgattgaacg ctgccgtcgt      300

catattgacg cctataaagc ccctacgcca gtagacgtta ttgaaggtga tattcgcgat      360

atcgccattg aaaacgcatc gatggtggtg ctgaatttta ccctgcaatt cctggaacct      420

tccgagcgcc aggcgttact ggataaaatt tatcaagggc tgaacccggg cggtgcgctg      480

gtgctttcgg aaaaattcag tttcgaagat gccaaagttg gtgaactgct gttcaacatg      540

caccacgact ttaaacgtgc caacggttac agcgaactgg agatcagcca gaaacgcagc      600

atgctggaaa acgtgatgct gaccgattcc gtggaaaccc ataaagcacg cctgcataaa      660

gccggttttg agcatagcga gctgtggttc cagtgcttta actttggttc actggtggca      720

ttaaaagcag aggacgctgc atga                                             744


<210> 1358
<211> 972
<212> DNA
<213> Escherichia coli

<400> 1358
atgatcgact ttggtaactt ttattctctg attgccaaaa atcatctttc acactggctc       60

gaaacgctgc ccgcgcagat tgctaactgg cagcgcgagc agcagcacgg gctgtttaag      120

cagtggtcca acgcggtgga atttctgcct gaaattaaac cgtatcgtct ggatttattg      180

catagcgtaa ccgccgaaag cgaagagcca ctgagcgccg ggcaaattaa gcgcattgaa      240

acgctgatgc gcaacctgat gccgtggcgc aaagggccgt tctcactgta tggcgtcaac      300

atcgataccg aatggcgttc cgactggaaa tgggatcgcg ttatgcccca tctttctgat      360

ttaaccgggc gcaccattct tgatgtcggc tgtggcagcg gttatcacat gtggcgcatg      420

attggcgcag gggcgcatct ggcggtgggt atcgatccca cgcagctatt cctctgccag      480

tttgaagcag tgcgtaaact gctgggtaac gatcagcgcg cacatttgtt accgttaggt      540

attgaacaac ttccggcact gaaagccttt gataccgtct tttcgatggg cgtgctttat      600

catcgtcgtt caccgctgga gcatctctgg cagttaaaag accaactggt gaatgaaggc      660

gaactggtgc tggaaacgct ggttattgat ggcgacgaaa acacggtgct ggtgccgggc      720

gatcgttacg ctcaaatgcg taatgtctat ttcattcctt ccgcgctggc gctgaaaaac      780

tggctgaaga agtgtggttt tgttgatatt cgcattgcag atgtgagcgt taccaccaca      840

gaagagcagc gacgcaccga atggatggtc accgagtctc tggccgattt tctcgacccg      900

catgatccgg gtaaaacggt ggaaggttat cctgcgccta aacgcgcggt gctgattgcg      960

cgcaagccgt aa                                                          972


<210> 1359
<211> 323
<212> PRT
<213> Escherichia coli

<400> 1359
Met Glu Thr Lys Lys Asn Asn Ser Glu Tyr Ile Pro Glu Phe Asp Lys 
1               5                   10                  15      


Ser Phe Arg His Pro Arg Tyr Trp Gly Ala Trp Leu Gly Val Ala Ala 
            20                  25                  30          


Met Ala Gly Ile Ala Leu Thr Pro Pro Lys Phe Arg Asp Pro Ile Leu 
        35                  40                  45              


Ala Arg Leu Gly Arg Phe Ala Gly Arg Leu Gly Lys Ser Ser Arg Arg 
    50                  55                  60                  


Arg Ala Leu Ile Asn Leu Ser Leu Cys Phe Pro Glu Arg Ser Glu Ala 
65                  70                  75                  80  


Glu Arg Glu Ala Ile Val Asp Glu Met Phe Ala Thr Ala Pro Gln Ala 
                85                  90                  95      


Met Val Met Met Ala Glu Leu Ala Ile Arg Gly Pro Glu Lys Ile Gln 
            100                 105                 110         


Pro Arg Val Asp Trp Gln Gly Leu Glu Ile Ile Glu Glu Ile Arg Arg 
        115                 120                 125             


Asn Asn Glu Lys Val Ile Phe Leu Val Pro His Gly Trp Ala Val Asp 
    130                 135                 140                 


Ile Pro Ala Met Leu Met Ala Ser Gln Gly Gln Lys Met Ala Ala Met 
145                 150                 155                 160 


Phe His Asn Gln Gly Asn Pro Val Phe Asp Tyr Val Trp Asn Thr Val 
                165                 170                 175     


Arg Arg Arg Phe Gly Gly Arg Leu His Ala Arg Asn Asp Gly Ile Lys 
            180                 185                 190         


Pro Phe Ile Gln Ser Val Arg Gln Gly Tyr Trp Gly Tyr Tyr Leu Pro 
        195                 200                 205             


Asp Gln Asp His Gly Pro Glu His Ser Glu Phe Val Asp Phe Phe Ala 
    210                 215                 220                 


Thr Tyr Lys Ala Thr Leu Pro Ala Ile Gly Arg Leu Met Lys Val Cys 
225                 230                 235                 240 


Arg Ala Arg Val Val Pro Leu Phe Pro Ile Tyr Asp Gly Lys Thr His 
                245                 250                 255     


Arg Leu Thr Ile Gln Val Arg Pro Pro Met Asp Asp Leu Leu Glu Ala 
            260                 265                 270         


Asp Asp His Thr Ile Ala Arg Arg Met Asn Glu Glu Val Glu Ile Phe 
        275                 280                 285             


Val Gly Pro Arg Pro Glu Gln Tyr Thr Trp Ile Leu Lys Leu Leu Lys 
    290                 295                 300                 


Thr Arg Lys Pro Gly Glu Ile Gln Pro Tyr Lys Arg Lys Asp Leu Tyr 
305                 310                 315                 320 


Pro Ile Lys 
            


<210> 1360
<211> 440
<212> PRT
<213> Escherichia coli

<400> 1360
Met Gln Gln Ile Ala Arg Ser Val Ala Leu Ala Phe Asn Asn Leu Pro 
1               5                   10                  15      


Arg Pro His Arg Val Met Leu Gly Ser Leu Thr Val Leu Thr Leu Ala 
            20                  25                  30          


Val Ala Val Trp Arg Pro Tyr Val Tyr His Arg Asp Ala Thr Pro Ile 
        35                  40                  45              


Val Lys Thr Ile Glu Leu Glu Gln Asn Glu Ile Arg Ser Leu Leu Pro 
    50                  55                  60                  


Glu Ala Ser Glu Pro Ile Asp Gln Ala Ala Gln Glu Asp Glu Ala Ile 
65                  70                  75                  80  


Pro Gln Asp Glu Leu Asp Asp Lys Ile Ala Gly Glu Ala Gly Val His 
                85                  90                  95      


Glu Tyr Val Val Ser Thr Gly Asp Thr Leu Ser Ser Ile Leu Asn Gln 
            100                 105                 110         


Tyr Gly Ile Asp Met Gly Asp Ile Thr Gln Leu Ala Ala Ala Asp Lys 
        115                 120                 125             


Glu Leu Arg Asn Leu Lys Ile Gly Gln Gln Leu Ser Trp Thr Leu Thr 
    130                 135                 140                 


Ala Asp Gly Glu Leu Gln Arg Leu Thr Trp Glu Val Ser Arg Arg Glu 
145                 150                 155                 160 


Thr Arg Thr Tyr Asp Arg Thr Ala Ala Asn Gly Phe Lys Met Thr Ser 
                165                 170                 175     


Glu Met Gln Gln Gly Glu Trp Val Asn Asn Leu Leu Lys Gly Thr Val 
            180                 185                 190         


Gly Gly Ser Phe Val Ala Ser Ala Arg Asn Ala Gly Leu Thr Ser Ala 
        195                 200                 205             


Glu Val Ser Ala Val Ile Lys Ala Met Gln Trp Gln Met Asp Phe Arg 
    210                 215                 220                 


Lys Leu Lys Lys Gly Asp Glu Phe Ala Val Leu Met Ser Arg Glu Met 
225                 230                 235                 240 


Leu Asp Gly Lys Arg Glu Gln Ser Gln Leu Leu Gly Val Arg Leu Arg 
                245                 250                 255     


Ser Glu Gly Lys Asp Tyr Tyr Ala Ile Arg Ala Glu Asp Gly Lys Phe 
            260                 265                 270         


Tyr Asp Arg Asn Gly Thr Gly Leu Ala Lys Gly Phe Leu Arg Phe Pro 
        275                 280                 285             


Thr Ala Lys Gln Phe Arg Ile Ser Ser Asn Phe Asn Pro Arg Arg Thr 
    290                 295                 300                 


Asn Pro Val Thr Gly Arg Val Ala Pro His Arg Gly Val Asp Phe Ala 
305                 310                 315                 320 


Met Pro Gln Gly Thr Pro Val Leu Ser Val Gly Asp Gly Glu Val Val 
                325                 330                 335     


Val Ala Lys Arg Ser Gly Ala Ala Gly Tyr Tyr Val Ala Ile Arg His 
            340                 345                 350         


Gly Arg Ser Tyr Thr Thr Arg Tyr Met His Leu Arg Lys Ile Leu Val 
        355                 360                 365             


Lys Pro Gly Gln Lys Val Lys Arg Gly Asp Arg Ile Ala Leu Ser Gly 
    370                 375                 380                 


Asn Thr Gly Arg Ser Thr Gly Pro His Leu His Tyr Glu Val Trp Ile 
385                 390                 395                 400 


Asn Gln Gln Ala Val Asn Pro Leu Thr Ala Lys Leu Pro Arg Thr Glu 
                405                 410                 415     


Gly Leu Thr Gly Ser Asp Arg Arg Glu Phe Leu Ala Gln Ala Lys Glu 
            420                 425                 430         


Ile Val Pro Gln Leu Arg Phe Asp 
        435                 440 


<210> 1361
<211> 310
<212> PRT
<213> Escherichia coli

<400> 1361
Met Leu His Lys Lys Thr Leu Leu Phe Ala Ala Leu Ser Ala Ala Leu 
1               5                   10                  15      


Trp Gly Gly Ala Thr Gln Ala Ala Asp Ala Ala Val Val Ala Ser Leu 
            20                  25                  30          


Lys Pro Val Gly Phe Ile Ala Ser Ala Ile Ala Asp Gly Val Thr Glu 
        35                  40                  45              


Thr Glu Val Leu Leu Pro Asp Gly Ala Ser Glu His Asp Tyr Ser Leu 
    50                  55                  60                  


Arg Pro Ser Asp Val Lys Arg Leu Gln Asn Ala Asp Leu Val Val Trp 
65                  70                  75                  80  


Val Gly Pro Glu Met Glu Ala Phe Met Gln Lys Pro Val Ser Lys Leu 
                85                  90                  95      


Pro Glu Ala Lys Gln Val Thr Ile Ala Gln Leu Glu Asn Val Lys Pro 
            100                 105                 110         


Leu Leu Met Lys Ser Ile His Gly Asp Asp Asp Asp His Asp His Ala 
        115                 120                 125             


Glu Lys Ser Asp Glu Asp His His His Gly Asp Phe Asn Met His Leu 
    130                 135                 140                 


Trp Leu Ser Pro Glu Ile Ala Arg Ala Thr Ala Val Ala Ile His Gly 
145                 150                 155                 160 


Lys Leu Val Glu Leu Met Pro Gln Ser Arg Ala Lys Leu Asp Ala Asn 
                165                 170                 175     


Leu Lys Asp Phe Glu Ala Gln Leu Ala Ser Thr Glu Lys Gln Val Gly 
            180                 185                 190         


Asn Glu Leu Ala Pro Leu Lys Gly Lys Gly Tyr Phe Val Phe His Asp 
        195                 200                 205             


Ala Tyr Gly Tyr Phe Glu Lys Gln Phe Gly Leu Thr Pro Leu Gly His 
    210                 215                 220                 


Phe Thr Val Asn Pro Glu Ile Gln Pro Gly Ala Gln Arg Leu His Glu 
225                 230                 235                 240 


Ile Arg Thr Gln Leu Val Glu Gln Lys Ala Thr Cys Val Phe Ala Glu 
                245                 250                 255     


Pro Gln Phe Arg Pro Ala Val Val Glu Ser Val Ala Arg Gly Thr Ser 
            260                 265                 270         


Val Arg Met Gly Thr Leu Asp Pro Leu Gly Thr Asn Ile Lys Leu Gly 
        275                 280                 285             


Lys Thr Ser Tyr Ser Glu Phe Leu Asn Gln Leu Ala Asn Gln Tyr Ala 
    290                 295                 300                 


Ser Cys Leu Lys Gly Asp 
305                 310 


<210> 1362
<211> 251
<212> PRT
<213> Escherichia coli

<400> 1362
Met Thr Ser Leu Val Ser Leu Glu Asn Val Ser Val Ser Phe Gly Gln 
1               5                   10                  15      


Arg Arg Val Leu Ser Asp Val Ser Leu Glu Leu Lys Pro Gly Lys Ile 
            20                  25                  30          


Leu Thr Leu Leu Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu Val Arg 
        35                  40                  45              


Val Val Leu Gly Leu Val Thr Pro Asp Glu Gly Val Ile Lys Arg Asn 
    50                  55                  60                  


Gly Lys Leu Arg Ile Gly Tyr Val Pro Gln Lys Leu Tyr Leu Asp Thr 
65                  70                  75                  80  


Thr Leu Pro Leu Thr Val Asn Arg Phe Leu Arg Leu Arg Pro Gly Thr 
                85                  90                  95      


His Lys Glu Asp Ile Leu Pro Ala Leu Lys Arg Val Gln Ala Gly His 
            100                 105                 110         


Leu Ile Asn Ala Pro Met Gln Lys Leu Ser Gly Gly Glu Thr Gln Arg 
        115                 120                 125             


Val Leu Leu Ala Arg Ala Leu Leu Asn Arg Pro Gln Leu Leu Val Leu 
    130                 135                 140                 


Asp Glu Pro Thr Gln Gly Val Asp Val Asn Gly Gln Val Ala Leu Tyr 
145                 150                 155                 160 


Asp Leu Ile Asp Gln Leu Arg Arg Glu Leu Asp Cys Gly Val Leu Met 
                165                 170                 175     


Val Ser His Asp Leu His Leu Val Met Ala Lys Thr Asp Glu Val Leu 
            180                 185                 190         


Cys Leu Asn His His Ile Cys Cys Ser Gly Thr Pro Glu Val Val Ser 
        195                 200                 205             


Leu His Pro Glu Phe Ile Ser Met Phe Gly Pro Arg Gly Ala Glu Gln 
    210                 215                 220                 


Leu Gly Ile Tyr Arg His His His Asn His Arg His Asp Leu Gln Gly 
225                 230                 235                 240 


Arg Ile Val Leu Arg Arg Gly Asn Asp Arg Ser 
                245                 250     


<210> 1363
<211> 261
<212> PRT
<213> Escherichia coli

<400> 1363
Met Ile Glu Leu Leu Phe Pro Gly Trp Leu Ala Gly Ile Met Leu Ala 
1               5                   10                  15      


Cys Ala Ala Gly Pro Leu Gly Ser Phe Val Val Trp Arg Arg Met Ser 
            20                  25                  30          


Tyr Phe Gly Asp Thr Leu Ala His Ala Ser Leu Leu Gly Val Ala Phe 
        35                  40                  45              


Gly Leu Leu Leu Asp Val Asn Pro Phe Tyr Ala Val Ile Ala Val Thr 
    50                  55                  60                  


Leu Leu Leu Ala Gly Gly Leu Val Trp Leu Glu Lys Arg Pro Gln Leu 
65                  70                  75                  80  


Ala Ile Asp Thr Leu Leu Gly Ile Met Ala His Ser Ala Leu Ser Leu 
                85                  90                  95      


Gly Leu Val Val Val Ser Leu Met Ser Asn Ile Arg Val Asp Leu Met 
            100                 105                 110         


Ala Tyr Leu Phe Gly Asp Leu Leu Ala Val Thr Pro Glu Asp Leu Ile 
        115                 120                 125             


Ser Ile Ala Ile Gly Val Val Ile Val Val Ala Ile Leu Phe Trp Gln 
    130                 135                 140                 


Trp Arg Asn Leu Leu Ser Met Thr Ile Ser Pro Asp Leu Ala Phe Val 
145                 150                 155                 160 


Asp Gly Val Lys Leu Gln Arg Val Lys Leu Leu Leu Met Leu Val Thr 
                165                 170                 175     


Ala Leu Thr Ile Gly Val Ala Met Lys Phe Val Gly Ala Leu Ile Ile 
            180                 185                 190         


Thr Ser Leu Leu Ile Ile Pro Ala Ala Thr Ala Arg Arg Phe Ala Arg 
        195                 200                 205             


Thr Pro Glu Gln Met Ala Gly Val Ala Val Leu Val Gly Met Val Ala 
    210                 215                 220                 


Val Thr Gly Gly Leu Thr Phe Ser Ala Phe Tyr Asp Thr Pro Ala Gly 
225                 230                 235                 240 


Pro Ser Val Val Leu Cys Ala Ala Leu Leu Phe Ile Ile Ser Met Met 
                245                 250                 255     


Lys Lys Gln Ala Ser 
            260     


<210> 1364
<211> 336
<212> PRT
<213> Escherichia coli

<400> 1364
Met Ile Glu Ala Asp Arg Leu Ile Ser Ala Gly Thr Thr Leu Pro Glu 
1               5                   10                  15      


Asp Val Ala Asp Arg Ala Ile Arg Pro Lys Leu Leu Glu Glu Tyr Val 
            20                  25                  30          


Gly Gln Pro Gln Val Arg Ser Gln Met Glu Ile Phe Ile Lys Ala Ala 
        35                  40                  45              


Lys Leu Arg Gly Asp Ala Leu Asp His Leu Leu Ile Phe Gly Pro Pro 
    50                  55                  60                  


Gly Leu Gly Lys Thr Thr Leu Ala Asn Ile Val Ala Asn Glu Met Gly 
65                  70                  75                  80  


Val Asn Leu Arg Thr Thr Ser Gly Pro Val Leu Glu Lys Ala Gly Asp 
                85                  90                  95      


Leu Ala Ala Met Leu Thr Asn Leu Glu Pro His Asp Val Leu Phe Ile 
            100                 105                 110         


Asp Glu Ile His Arg Leu Ser Pro Val Val Glu Glu Val Leu Tyr Pro 
        115                 120                 125             


Ala Met Glu Asp Tyr Gln Leu Asp Ile Met Ile Gly Glu Gly Pro Ala 
    130                 135                 140                 


Ala Arg Ser Ile Lys Ile Asp Leu Pro Pro Phe Thr Leu Ile Gly Ala 
145                 150                 155                 160 


Thr Thr Arg Ala Gly Ser Leu Thr Ser Pro Leu Arg Asp Arg Phe Gly 
                165                 170                 175     


Ile Val Gln Arg Leu Glu Phe Tyr Gln Val Pro Asp Leu Gln Tyr Ile 
            180                 185                 190         


Val Ser Arg Ser Ala Arg Phe Met Gly Leu Glu Met Ser Asp Asp Gly 
        195                 200                 205             


Ala Leu Glu Val Ala Arg Arg Ala Arg Gly Thr Pro Arg Ile Ala Asn 
    210                 215                 220                 


Arg Leu Leu Arg Arg Val Arg Asp Phe Ala Glu Val Lys His Asp Gly 
225                 230                 235                 240 


Thr Ile Ser Ala Asp Ile Ala Ala Gln Ala Leu Asp Met Leu Asn Val 
                245                 250                 255     


Asp Ala Glu Gly Phe Asp Tyr Met Asp Arg Lys Leu Leu Leu Ala Val 
            260                 265                 270         


Ile Asp Lys Phe Phe Gly Gly Pro Val Gly Leu Asp Asn Leu Ala Ala 
        275                 280                 285             


Ala Ile Gly Glu Glu Arg Glu Thr Ile Glu Asp Val Leu Glu Pro Tyr 
    290                 295                 300                 


Leu Ile Gln Gln Gly Phe Leu Gln Arg Thr Pro Arg Gly Arg Met Ala 
305                 310                 315                 320 


Thr Val Arg Ala Trp Asn His Phe Gly Ile Thr Pro Pro Glu Met Pro 
                325                 330                 335     


<210> 1365
<211> 203
<212> PRT
<213> Escherichia coli

<400> 1365
Met Ile Gly Arg Leu Arg Gly Ile Ile Ile Glu Lys Gln Pro Pro Leu 
1               5                   10                  15      


Val Leu Ile Glu Val Gly Gly Val Gly Tyr Glu Val His Met Pro Met 
            20                  25                  30          


Thr Cys Phe Tyr Glu Leu Pro Glu Ala Gly Gln Glu Ala Ile Val Phe 
        35                  40                  45              


Thr His Phe Val Val Arg Glu Asp Ala Gln Leu Leu Tyr Gly Phe Asn 
    50                  55                  60                  


Asn Lys Gln Glu Arg Thr Leu Phe Lys Glu Leu Ile Lys Thr Asn Gly 
65                  70                  75                  80  


Val Gly Pro Lys Leu Ala Leu Ala Ile Leu Ser Gly Met Ser Ala Gln 
                85                  90                  95      


Gln Phe Val Asn Ala Val Glu Arg Glu Glu Val Gly Ala Leu Val Lys 
            100                 105                 110         


Leu Pro Gly Ile Gly Lys Lys Thr Ala Glu Arg Leu Ile Val Glu Met 
        115                 120                 125             


Lys Asp Arg Phe Lys Gly Leu His Gly Asp Leu Phe Thr Pro Ala Ala 
    130                 135                 140                 


Asp Leu Val Leu Thr Ser Pro Ala Ser Pro Ala Thr Asp Asp Ala Glu 
145                 150                 155                 160 


Gln Glu Ala Val Ala Ala Leu Val Ala Leu Gly Tyr Lys Pro Gln Glu 
                165                 170                 175     


Ala Ser Arg Met Val Ser Lys Ile Ala Arg Pro Asp Ala Ser Ser Glu 
            180                 185                 190         


Thr Leu Ile Arg Glu Ala Leu Arg Ala Ala Leu 
        195                 200             


<210> 1366
<211> 200
<212> PRT
<213> Escherichia coli

<400> 1366
Met Asn Ile Asn Tyr Pro Ala Glu Tyr Glu Ile Gly Asp Ile Val Phe 
1               5                   10                  15      


Thr Cys Ile Ser Ala Ala Leu Phe Gly Gln Ile Ser Ala Ala Ser Asn 
            20                  25                  30          


Cys Trp Ser Asn His Val Gly Ile Ile Ile Gly His Asn Gly Glu Asp 
        35                  40                  45              


Phe Leu Val Ala Glu Ser Arg Val Pro Leu Ser Thr Ile Thr Thr Leu 
    50                  55                  60                  


Ser Arg Phe Ile Lys Arg Ser Ala Asn Gln Arg Tyr Ala Ile Lys Arg 
65                  70                  75                  80  


Leu Asp Ala Gly Leu Thr Glu Gln Gln Asn Gln Arg Ile Val Glu Gln 
                85                  90                  95      


Val Pro Ser Arg Leu Arg Lys Ile Tyr His Thr Gly Phe Lys Tyr Glu 
            100                 105                 110         


Ser Ser Arg Gln Phe Cys Ser Lys Phe Val Phe Asp Ile Tyr Lys Glu 
        115                 120                 125             


Ala Leu Cys Ile Pro Val Gly Glu Ile Glu Thr Phe Gly Glu Leu Leu 
    130                 135                 140                 


Asn Ser Asn Pro Asn Ala Lys Leu Thr Phe Trp Lys Phe Trp Phe Leu 
145                 150                 155                 160 


Gly Ser Ile Pro Trp Glu Arg Lys Thr Val Thr Pro Ala Ser Leu Trp 
                165                 170                 175     


His His Pro Gly Leu Val Leu Ile His Ala Val Gly Val Glu Thr Pro 
            180                 185                 190         


Gln Pro Glu Leu Thr Glu Ala Val 
        195                 200 


<210> 1367
<211> 173
<212> PRT
<213> Escherichia coli

<400> 1367
Met Ala Ile Ile Leu Gly Ile Asp Pro Gly Ser Arg Val Thr Gly Tyr 
1               5                   10                  15      


Gly Val Ile Arg Gln Val Gly Arg Gln Leu Ser Tyr Leu Gly Ser Gly 
            20                  25                  30          


Cys Ile Arg Thr Lys Val Asp Asp Leu Pro Ser Arg Leu Lys Leu Ile 
        35                  40                  45              


Tyr Ala Gly Val Thr Glu Ile Ile Thr Gln Phe Gln Pro Asp Tyr Phe 
    50                  55                  60                  


Ala Ile Glu Gln Val Phe Met Ala Lys Asn Ala Asp Ser Ala Leu Lys 
65                  70                  75                  80  


Leu Gly Gln Ala Arg Gly Val Ala Ile Val Ala Ala Val Asn Gln Glu 
                85                  90                  95      


Leu Pro Val Phe Glu Tyr Ala Ala Arg Gln Val Lys Gln Thr Val Val 
            100                 105                 110         


Gly Ile Gly Ser Ala Glu Lys Ser Gln Val Gln His Met Val Arg Thr 
        115                 120                 125             


Leu Leu Lys Leu Pro Ala Asn Pro Gln Ala Asp Ala Ala Asp Ala Leu 
    130                 135                 140                 


Ala Ile Ala Ile Thr His Cys His Val Ser Gln Asn Ala Met Gln Met 
145                 150                 155                 160 


Ser Glu Ser Arg Leu Asn Leu Ala Arg Gly Arg Leu Arg 
                165                 170             


<210> 1368
<211> 246
<212> PRT
<213> Escherichia coli

<400> 1368
Met Ala Gly His Ser Lys Trp Ala Asn Thr Arg His Arg Lys Ala Ala 
1               5                   10                  15      


Gln Asp Ala Lys Arg Gly Lys Ile Phe Thr Lys Ile Ile Arg Glu Leu 
            20                  25                  30          


Val Thr Ala Ala Lys Leu Gly Gly Gly Asp Pro Asp Ala Asn Pro Arg 
        35                  40                  45              


Leu Arg Ala Ala Ile Asp Lys Ala Leu Ser Asn Asn Met Thr Arg Asp 
    50                  55                  60                  


Thr Leu Asn Arg Ala Ile Ala Arg Gly Val Gly Gly Asp Asp Asp Ala 
65                  70                  75                  80  


Asn Met Glu Thr Ile Ile Tyr Glu Gly Tyr Gly Pro Gly Gly Thr Ala 
                85                  90                  95      


Ile Met Ile Glu Cys Leu Ser Asp Asn Arg Asn Arg Thr Val Ala Glu 
            100                 105                 110         


Val Arg His Ala Phe Ser Lys Cys Gly Gly Asn Leu Gly Thr Asp Gly 
        115                 120                 125             


Ser Val Ala Tyr Leu Phe Ser Lys Lys Gly Val Ile Ser Phe Glu Lys 
    130                 135                 140                 


Gly Asp Glu Asp Thr Ile Met Glu Ala Ala Leu Glu Ala Gly Ala Glu 
145                 150                 155                 160 


Asp Val Val Thr Tyr Asp Asp Gly Ala Ile Asp Val Tyr Thr Ala Trp 
                165                 170                 175     


Glu Glu Met Gly Lys Val Arg Asp Ala Leu Glu Ala Ala Gly Leu Lys 
            180                 185                 190         


Ala Asp Ser Ala Glu Val Ser Met Ile Pro Ser Thr Lys Ala Asp Met 
        195                 200                 205             


Asp Ala Glu Thr Ala Pro Lys Leu Met Arg Leu Ile Asp Met Leu Glu 
    210                 215                 220                 


Asp Cys Asp Asp Val Gln Glu Val Tyr His Asn Gly Glu Ile Ser Asp 
225                 230                 235                 240 


Glu Val Ala Ala Thr Leu 
                245     


<210> 1369
<211> 147
<212> PRT
<213> Escherichia coli

<400> 1369
Met Ala Tyr Lys Arg Pro Val Ser Ile Leu Val Val Ile Tyr Ala Gln 
1               5                   10                  15      


Asp Thr Lys Arg Val Leu Met Leu Gln Arg Arg Asp Asp Pro Asp Phe 
            20                  25                  30          


Trp Gln Ser Val Thr Gly Ser Val Glu Glu Gly Glu Thr Ala Pro Gln 
        35                  40                  45              


Ala Ala Met Arg Glu Val Lys Glu Glu Val Thr Ile Asp Val Val Ala 
    50                  55                  60                  


Glu Gln Leu Thr Leu Ile Asp Cys Gln Arg Thr Val Glu Phe Glu Ile 
65                  70                  75                  80  


Phe Ser His Leu Arg His Arg Tyr Ala Pro Gly Val Thr Arg Asn Thr 
                85                  90                  95      


Glu Ser Trp Phe Cys Leu Ala Leu Pro His Glu Arg Gln Ile Val Phe 
            100                 105                 110         


Thr Glu His Leu Ala Tyr Lys Trp Leu Asp Ala Ser Ala Ala Ala Ala 
        115                 120                 125             


Leu Thr Lys Ser Trp Ser Asn Arg Gln Ala Ile Glu Gln Phe Val Ile 
    130                 135                 140                 


Asn Ala Ala 
145         


<210> 1370
<211> 590
<212> PRT
<213> Escherichia coli

<400> 1370
Met Arg Thr Glu Tyr Cys Gly Gln Leu Arg Leu Ser His Val Gly Gln 
1               5                   10                  15      


Gln Val Thr Leu Cys Gly Trp Val Asn Arg Arg Arg Asp Leu Gly Ser 
            20                  25                  30          


Leu Ile Phe Ile Asp Met Arg Asp Arg Glu Gly Ile Val Gln Val Phe 
        35                  40                  45              


Phe Asp Pro Asp Arg Ala Asp Ala Leu Lys Leu Ala Ser Glu Leu Arg 
    50                  55                  60                  


Asn Glu Phe Cys Ile Gln Val Thr Gly Thr Val Arg Ala Arg Asp Glu 
65                  70                  75                  80  


Lys Asn Ile Asn Arg Asp Met Ala Thr Gly Glu Ile Glu Val Leu Ala 
                85                  90                  95      


Ser Ser Leu Thr Ile Ile Asn Arg Ala Asp Val Leu Pro Leu Asp Ser 
            100                 105                 110         


Asn His Val Asn Thr Glu Glu Ala Arg Leu Lys Tyr Arg Tyr Leu Asp 
        115                 120                 125             


Leu Arg Arg Pro Glu Met Ala Gln Arg Leu Lys Thr Arg Ala Lys Ile 
    130                 135                 140                 


Thr Ser Leu Val Arg Arg Phe Met Asp Asp His Gly Phe Leu Asp Ile 
145                 150                 155                 160 


Glu Thr Pro Met Leu Thr Lys Ala Thr Pro Glu Gly Ala Arg Asp Tyr 
                165                 170                 175     


Leu Val Pro Ser Arg Val His Lys Gly Lys Phe Tyr Ala Leu Pro Gln 
            180                 185                 190         


Ser Pro Gln Leu Phe Lys Gln Leu Leu Met Met Ser Gly Phe Asp Arg 
        195                 200                 205             


Tyr Tyr Gln Ile Val Lys Cys Phe Arg Asp Glu Asp Leu Arg Ala Asp 
    210                 215                 220                 


Arg Gln Pro Glu Phe Thr Gln Ile Asp Val Glu Thr Ser Phe Met Thr 
225                 230                 235                 240 


Ala Pro Gln Val Arg Glu Val Met Glu Ala Leu Val Arg His Leu Trp 
                245                 250                 255     


Leu Glu Val Lys Gly Val Asp Leu Gly Asp Phe Pro Val Met Thr Phe 
            260                 265                 270         


Ala Glu Ala Glu Arg Arg Tyr Gly Ser Asp Lys Pro Asp Leu Arg Asn 
        275                 280                 285             


Pro Met Glu Leu Thr Asp Val Ala Asp Leu Leu Lys Ser Val Glu Phe 
    290                 295                 300                 


Ala Val Phe Ala Gly Pro Ala Asn Asp Pro Lys Gly Arg Val Ala Ala 
305                 310                 315                 320 


Leu Arg Val Pro Gly Gly Ala Ser Leu Thr Arg Lys Gln Ile Asp Glu 
                325                 330                 335     


Tyr Gly Asn Phe Val Lys Ile Tyr Gly Ala Lys Gly Leu Ala Tyr Ile 
            340                 345                 350         


Lys Val Asn Glu Arg Ala Lys Gly Leu Glu Gly Ile Asn Ser Pro Val 
        355                 360                 365             


Ala Lys Phe Leu Asn Ala Glu Ile Ile Glu Ala Ile Leu Glu Arg Thr 
    370                 375                 380                 


Gly Ala Gln Asp Gly Asp Met Ile Phe Phe Gly Ala Asp Asn Lys Lys 
385                 390                 395                 400 


Ile Val Ala Asp Ala Met Gly Ala Leu Arg Leu Lys Val Gly Lys Asp 
                405                 410                 415     


Leu Gly Leu Thr Asp Glu Ser Lys Trp Ala Pro Leu Trp Val Ile Asp 
            420                 425                 430         


Phe Pro Met Phe Glu Asp Asp Gly Glu Gly Gly Leu Thr Ala Met His 
        435                 440                 445             


His Pro Phe Thr Ser Pro Lys Asp Met Thr Ala Ala Glu Leu Lys Ala 
    450                 455                 460                 


Ala Pro Glu Asn Ala Val Ala Asn Ala Tyr Asp Met Val Ile Asn Gly 
465                 470                 475                 480 


Tyr Glu Val Gly Gly Gly Ser Val Arg Ile His Asn Gly Asp Met Gln 
                485                 490                 495     


Gln Thr Val Phe Gly Ile Leu Gly Ile Asn Glu Glu Glu Gln Arg Glu 
            500                 505                 510         


Lys Phe Gly Phe Leu Leu Asp Ala Leu Lys Tyr Gly Thr Pro Pro His 
        515                 520                 525             


Ala Gly Leu Ala Phe Gly Leu Asp Arg Leu Thr Met Leu Leu Thr Gly 
    530                 535                 540                 


Thr Asp Asn Ile Arg Asp Val Ile Ala Phe Pro Lys Thr Thr Ala Ala 
545                 550                 555                 560 


Ala Cys Leu Met Thr Glu Ala Pro Ser Phe Ala Asn Pro Thr Ala Leu 
                565                 570                 575     


Ala Glu Leu Ser Ile Gln Val Val Lys Lys Ala Glu Asn Asn 
            580                 585                 590 


<210> 1371
<211> 188
<212> PRT
<213> Escherichia coli

<400> 1371
Met Leu Glu Leu Asn Ala Lys Thr Thr Ala Leu Val Val Ile Asp Leu 
1               5                   10                  15      


Gln Glu Gly Ile Leu Pro Phe Ala Gly Gly Pro His Thr Ala Asp Glu 
            20                  25                  30          


Val Val Asn Arg Ala Gly Lys Leu Ala Ala Lys Phe Arg Ala Ser Gly 
        35                  40                  45              


Gln Pro Val Phe Leu Val Arg Val Gly Trp Ser Ala Asp Tyr Ala Glu 
    50                  55                  60                  


Ala Leu Lys Gln Pro Val Asp Ala Pro Ser Pro Ala Lys Val Leu Pro 
65                  70                  75                  80  


Glu Asn Trp Trp Gln His Pro Ala Ala Leu Gly Ala Thr Asp Ser Asp 
                85                  90                  95      


Ile Glu Ile Ile Lys Arg Gln Trp Gly Ala Phe Tyr Gly Thr Asp Leu 
            100                 105                 110         


Glu Leu Gln Leu Arg Arg Arg Gly Ile Asp Thr Ile Val Leu Cys Gly 
        115                 120                 125             


Ile Ser Thr Asn Ile Gly Val Glu Ser Thr Ala Arg Asn Ala Trp Glu 
    130                 135                 140                 


Leu Gly Phe Asn Leu Val Ile Ala Glu Asp Ala Cys Ser Ala Ala Ser 
145                 150                 155                 160 


Ala Glu Gln His Asn Asn Ser Ile Asn His Ile Tyr Pro Arg Ile Ala 
                165                 170                 175     


Arg Val Arg Ser Val Glu Glu Ile Leu Asn Ala Leu 
            180                 185             


<210> 1372
<211> 129
<212> PRT
<213> Escherichia coli

<400> 1372
Met Gly Phe Pro Ser Pro Ala Ala Asp Tyr Val Glu Thr Arg Ile Ser 
1               5                   10                  15      


Leu Asp Gln Gln Leu Ile Ser Gln Pro Ala Ala Thr Tyr Phe Met Arg 
            20                  25                  30          


Ala Ser Arg Ser His Phe Arg Glu Gly Ile Ile Gln Gly Ala Leu Leu 
        35                  40                  45              


Val Val Asp Ala Ser Leu Thr Ala Cys Asp Gly Ser Leu Leu Ile Cys 
    50                  55                  60                  


Ala Ile Asp Gly Glu Phe Arg Ile Lys Arg Tyr Arg Thr His Pro Gln 
65                  70                  75                  80  


Pro His Leu Val Asn Leu Asp Asn Gly Arg Arg Glu Ala Leu Pro Ala 
                85                  90                  95      


Asp Asp Asp Gly Tyr Ser Ser Ala Pro Ala Ile Phe Gly Val Ile Thr 
            100                 105                 110         


Tyr Ile Ile Asn Asp Ala Arg Asn Ala Glu Phe Asp Asp Cys Pro Val 
        115                 120                 125             


Met 
    


<210> 1373
<211> 80
<212> PRT
<213> Escherichia coli

<400> 1373
Met Phe Val Glu Leu Val Tyr Asp Lys Arg Asn Phe Asp Gly Leu Pro 
1               5                   10                  15      


Gly Ala Lys Asp Ile Ile Leu Gly Glu Leu Thr Lys Arg Val His Arg 
            20                  25                  30          


Ile Phe Pro Asp Ala Asp Val Arg Val Lys Pro Met Met Thr Leu Pro 
        35                  40                  45              


Ala Ile Asn Thr Asp Ala Ser Lys His Glu Lys Glu Gln Ile Ser Arg 
    50                  55                  60                  


Thr Val Gln Glu Met Phe Glu Glu Ala Glu Phe Trp Leu Val Ser Glu 
65                  70                  75                  80  


<210> 1374
<211> 126
<212> PRT
<213> Escherichia coli

<400> 1374
Met Leu Trp Arg Ile Phe Ile Phe Val Asn Val Gly Leu Gly Glu Ala 
1               5                   10                  15      


Ala Lys Arg Asn Val Gly Thr Gly Glu Asn Gln Ile Pro Asp Met Ser 
            20                  25                  30          


Ala Phe Pro Ser Gly Asn Asn Trp Phe Gln Leu Pro Ser Gly His Ile 
        35                  40                  45              


Val Gln Ile Phe Ser Met Asn Val Leu Gly Ala Asp Ala Asn Gly Thr 
    50                  55                  60                  


Ser Ala Asn Tyr Pro Ile Ala Phe Pro Thr Thr Met Ile Ala Val Ser 
65                  70                  75                  80  


Ala Leu Trp Ser Asp Gly Thr Val Ala Asn Ala Pro Thr Tyr Lys Met 
                85                  90                  95      


Met Gly Asn Thr Thr Asn Arg Thr Thr Leu Thr Ile Lys Val Ser Ala 
            100                 105                 110         


Ser Ser Gly Thr Tyr Gly Thr Met Ile Ile Ala Val Gly Arg 
        115                 120                 125     


<210> 1375
<211> 147
<212> PRT
<213> Escherichia coli

<400> 1375
Met Asn Lys Tyr Ser Tyr Ser Pro Ser Glu Asn Ala Phe Tyr Ala Val 
1               5                   10                  15      


Ala Leu Lys Asn Thr Tyr Glu Leu Ser Gly Thr Trp Pro Ala Asp Ala 
            20                  25                  30          


Leu Asp Ile Pro Asp Asp Ile Ser Val Lys Tyr Met Ala Glu Pro Pro 
        35                  40                  45              


Gln Gly Lys Ile Arg Val Ala Gly Glu Asn Gly Phe Pro Thr Trp Ala 
    50                  55                  60                  


Glu Ile Pro Pro Pro Ser His Glu Glu Leu Ile Glu Gln Ala Glu Ser 
65                  70                  75                  80  


Glu Arg Gln Leu Leu Ile Asn Gln Ala Asn Glu Tyr Met Asn Ser Lys 
                85                  90                  95      


Gln Trp Pro Gly Lys Ala Ala Ile Gly Arg Leu Lys Gly Glu Glu Leu 
            100                 105                 110         


Ala Gln Tyr Asn Ser Trp Leu Asp Tyr Leu Asp Ala Leu Glu Leu Val 
        115                 120                 125             


Asp Thr Ser Gly Thr Pro Asp Ile Glu Trp Pro Thr Pro Pro Ala Val 
    130                 135                 140                 


Gln Ala Arg 
145         


<210> 1376
<211> 197
<212> PRT
<213> Escherichia coli

<400> 1376
Met Lys Pro Val Phe Asp Glu Asn Gly Leu Ala Ala Val Pro Gly Asp 
1               5                   10                  15      


Met Arg Cys Phe Tyr Tyr Asp Ala Val Thr Ser Glu Tyr Thr Gly Trp 
            20                  25                  30          


Ser Asp Glu Tyr Ile Asn Thr Gly Val Ser Met Pro Ala Cys Ser Thr 
        35                  40                  45              


Gly Ile Asp Pro Asp Glu Asn Ile Pro Gly Arg Val Ala Val Phe Thr 
    50                  55                  60                  


Gly Lys Gly Trp Ser His Glu Glu Asp His Arg Asn Glu Thr Val Tyr 
65                  70                  75                  80  


Ser Ile Glu Asn Gly Ala Ala Val Thr Val Asp Tyr Ile Gly Ala Ile 
                85                  90                  95      


Lys Asn Gly Tyr Val Thr Leu Ser Pro Leu Thr Pro Tyr Asp Lys Trp 
            100                 105                 110         


Asp Gly Glu Lys Trp Val Thr Asp Thr Glu Ala Gln His Gly Ala Ser 
        115                 120                 125             


Val Glu Ala Ala Glu Ala Gln Arg Gln Ser Leu Ile Asp Ala Ala Met 
    130                 135                 140                 


Ala Ser Ile Ser Leu Ile Gln Leu Lys Leu Gln Ala Gly Arg Lys Leu 
145                 150                 155                 160 


Thr Gln Ala Glu Thr Thr Arg Leu Asn Ala Val Leu Asp Tyr Ile Asp 
                165                 170                 175     


Ala Val Thr Ala Thr Asp Thr Ser Thr Ala Pro Asp Val Ile Trp Pro 
            180                 185                 190         


Glu Leu Pro Glu Ala 
        195         


<210> 1377
<211> 310
<212> PRT
<213> Escherichia coli

<400> 1377
Met Ile Tyr Ser Thr Gly Thr Ile Ser Ile Asn Gly Asn Thr Ala Thr 
1               5                   10                  15      


Gly Ser Gly Thr Asn Trp Thr Ala Pro Ala Ser Gln Val Arg Ala Gly 
            20                  25                  30          


Gln Thr Ile Ile Val Met Ser Asn Pro Val Gln Leu Phe Gln Ile Ser 
        35                  40                  45              


Ser Val Asn Ser Ala Thr Ser Met Thr Val Thr Pro Ala Val Ser Pro 
    50                  55                  60                  


Ala Leu Ser Gly Gln Lys Tyr Gly Ile Leu Val Ser Asp Asn Ile Ser 
65                  70                  75                  80  


Val Asp Gly Leu Ala Gln Ala Met Ser Gln Leu Ile Lys Glu Tyr Asp 
                85                  90                  95      


Glu Asn Ile Gly Ala Trp Glu Thr Phe Ala Thr Thr Ser Ala Asn Gln 
            100                 105                 110         


Ser Ile Thr Val Thr Ile Asn Gly Thr Ala Val Thr Ile Pro Gly Ile 
        115                 120                 125             


Gly Lys Leu Ala Gln Lys Gly Ser Asn Gly Ala Val Thr Val Ala Asp 
    130                 135                 140                 


Gly Gly Thr Gly Ala Thr Asn Ala Ala Asp Ala Arg Thr Asn Leu Gly 
145                 150                 155                 160 


Leu Gly Glu Gly Ser Pro Ala Ile Gly Val Pro Phe Phe Trp Pro Ser 
                165                 170                 175     


Ala Ala Met Pro Asn Thr Val Ile Asp Ser Trp Ser Ser Met Val Phe 
            180                 185                 190         


Leu Lys Phe Asn Gly Ala Lys Phe Ser Ala Thr Asp Tyr Pro Val Leu 
        195                 200                 205             


Ala Lys Val Phe Pro Ser Leu Val Leu Pro Glu Ala Arg Gly Asp Phe 
    210                 215                 220                 


Ile Arg Val Trp Asp Asp Gly Arg Gly Ala Asp Gly Gly Arg Glu Leu 
225                 230                 235                 240 


Leu Ser Trp Gln Glu Ala Thr Asn Phe Ser Gln Phe Ala Gly Asn Ile 
                245                 250                 255     


Gly Gly Gly Ala Gly His Ala Ile Asn Phe His Asp Gly Ile Ala Gly 
            260                 265                 270         


Asn Gln Pro Gly Phe Ser Arg Phe Asn Phe Asn Ser Asn Ser Val Gly 
        275                 280                 285             


Asp Gly Val Asn Phe Val Ala Val Arg Pro Arg Asn Ile Ala Phe Asn 
    290                 295                 300                 


Phe Leu Val Arg Ala Lys 
305                 310 


<210> 1378
<211> 1308
<212> PRT
<213> Escherichia coli

<400> 1378
Met Gly Glu Lys Met Gln Leu Leu Lys Gln Glu Thr Ile Leu Gln Gly 
1               5                   10                  15      


Ala Lys Gly Gly Gly Gly Ser Ser His Thr Pro Val Glu Gln Pro Asp 
            20                  25                  30          


Asp Leu Leu Ser Val Ala Lys Leu Lys Met Leu Ile Ala Val Ser Glu 
        35                  40                  45              


Gly Glu Ile Gln Gly Asp Leu Thr Ala Gln Asn Ile Phe Leu Asn Asp 
    50                  55                  60                  


Thr Pro Leu Ala Asn Asp Ser Gly Glu Tyr Asn Phe Ser Gly Val Lys 
65                  70                  75                  80  


Trp Glu Phe Arg Lys Gly Thr Gln Asp Gln Thr Tyr Ile Ala Gly Met 
                85                  90                  95      


Pro Gln Val Asp Asn Glu Leu Ala Val Gly Thr Thr Val Thr Thr Thr 
            100                 105                 110         


Ala Pro Trp Thr Arg Gln Phe Thr Asn Leu Ser Leu Asp Ala Ile Arg 
        115                 120                 125             


Ile Lys Leu Ser Leu Pro Val Gln Tyr Leu Tyr Lys Asp Asn Gly Asp 
    130                 135                 140                 


Met Val Gly Thr Val Thr Glu Tyr Ala Ile Asp Leu Ser Thr Asp Gly 
145                 150                 155                 160 


Gly Ala Trp Lys Thr Val Val Asn Gly Lys Phe Asp Gly Lys Thr Thr 
                165                 170                 175     


Thr Glu Tyr Gln Arg Asp His Arg Ile Asp Leu Pro Lys Ser Thr Ser 
            180                 185                 190         


Gly Trp Ser Val Arg Val Arg Arg Ile Thr Ala Asp Ala Ser Gly Ser 
        195                 200                 205             


Asn Ser Lys Leu Val Asn Ala Phe Lys Val Phe Ser Tyr Ala Glu Val 
    210                 215                 220                 


Ile Asp Ser Lys Leu Arg Tyr Pro Leu Thr Ala Leu Leu Tyr Val Glu 
225                 230                 235                 240 


Val Asp Ser Ser Gln Phe Asn Gly Ser Ala Pro Lys Val Thr Cys Lys 
                245                 250                 255     


Ile Lys Gly Lys Leu Ile Lys Val Pro Asp Asn Tyr Asp Pro Lys Thr 
            260                 265                 270         


Arg Thr Tyr Ser Gly Ser Trp Ser Gly Gly Phe Lys Met Ala Trp Ser 
        275                 280                 285             


Asn Asn Pro Ala Trp Ile Phe Tyr Asp Leu Val Leu Asp Glu Ile Tyr 
    290                 295                 300                 


Gly Met Gly Thr Arg Val Asp Ala Ser Met Val Asp Lys Trp Ala Leu 
305                 310                 315                 320 


Tyr Ser Ile Ala Gln Tyr Cys Asp Glu Met Val Ser Asp Gly Ala Gly 
                325                 330                 335     


Gly Thr Glu Pro Arg Phe Thr Cys Asn Val Phe Ile Gln Ser Gln Glu 
            340                 345                 350         


Asp Ala Trp Gln Val Leu Asn Asp Leu Ala Ala Val Phe Arg Gly Ile 
        355                 360                 365             


Thr Phe Trp Gly Asn Asp Gln Ile Tyr Val Gln Ala Asp Val Pro Gln 
    370                 375                 380                 


Asp Asp Val Asp Trp Val Tyr Asn Val Ser Asn Val Ile Asp Gly Leu 
385                 390                 395                 400 


Phe Thr Tyr Ala Gly Gly Ser Tyr Lys Asn Arg Tyr Ser Ser Cys Leu 
                405                 410                 415     


Val Ser Trp Ser Asp Pro Gln Asn His Tyr Ser Asp Thr Val Glu Gly 
            420                 425                 430         


Val Tyr Asp Ser Ala Leu Val Glu Arg Tyr Asp Val Arg Gln Thr Ser 
        435                 440                 445             


Leu Thr Ala Ile Gly Cys Thr Ser Gln Ser Glu Ala His Arg Arg Gly 
    450                 455                 460                 


Arg Trp Val Leu Leu Ser Asn Ala Lys Asp Gly Thr Val Ser Phe Gly 
465                 470                 475                 480 


Val Gly Leu Asp Gly Tyr Ile Pro Leu Pro Ala Glu Ile Ile Gly Val 
                485                 490                 495     


Ala Asp Pro Phe Arg Ser Gly Lys Glu Asn Gly Gly Arg Ile Ser Ala 
            500                 505                 510         


Ala Asn Gly Arg Gln Ile Thr Leu Asp Arg Glu Ile Asp Tyr Ala Ala 
        515                 520                 525             


Lys Asp Arg Leu Val Val Asn Leu Pro Asp Gly Lys Ala Gln Thr Arg 
    530                 535                 540                 


Thr Ile Ser Ala Val Ser Ala Asp Lys Lys Thr Val Thr Val Ala Thr 
545                 550                 555                 560 


Ala Phe Ser Gln Val Pro Val Ala Gly Ala Val Trp Ala Ile Asp Ser 
                565                 570                 575     


Asp Asn Leu Ala Ile Gln Tyr Phe Arg Val Thr Ser Ile Ala Ala Asn 
            580                 585                 590         


Asp Asp Ser Thr Gly Gly Phe Thr Ile Thr Ala Val Gln His Asp Pro 
        595                 600                 605             


Asn Lys Tyr Arg Tyr Ile Asp Asp Gly Val Arg Val Glu Ser Pro Pro 
    610                 615                 620                 


Ile Thr Val Thr Pro Ile Ser Val Leu Ser Ala Pro Lys Asn Ile Val 
625                 630                 635                 640 


Val Thr Glu Ser Asp His Val Ser Gln Gly Leu Thr Val Ala Ser Leu 
                645                 650                 655     


Asp Val Ser Trp Asp Lys Val Glu Gly Ala Ile Arg Tyr Val Ala Gln 
            660                 665                 670         


Trp Arg Lys Asp Asn Gly Asp Trp Ile Asn Val Pro Val Thr Ser Ala 
        675                 680                 685             


Gln Gly Phe Ser Val Gln Gly Ile Tyr Ser Gly Ser Tyr Asp Val Arg 
    690                 695                 700                 


Val Arg Ala Leu Asn Ala Gln Asp Thr Ser Ser Pro Trp Gly Tyr Gly 
705                 710                 715                 720 


Glu Thr Thr Tyr Leu Ser Gly Lys Thr Gly Lys Pro Gly Thr Pro Leu 
                725                 730                 735     


Asn Phe Leu Ala Thr Glu Asp Val Val Trp His Ile Asp Leu Thr Trp 
            740                 745                 750         


Lys Phe Pro Asp Gly Ser Gly Asp Thr Ala Tyr Thr Glu Ile Gln Arg 
        755                 760                 765             


Ala Thr Thr Ala Asp Tyr Ala Asn Pro Glu Leu Leu Val Leu Val Pro 
    770                 775                 780                 


Tyr Pro Ala Ala Asp Tyr Gln His Gly Pro Met Pro Ala Gly Val Arg 
785                 790                 795                 800 


Gln Trp Tyr Arg Ala Arg Leu Ile Asp Arg Ile Gly Asn Ala Gly Asp 
                805                 810                 815     


Trp Thr Asp Trp Ile Met Gly Thr Ser Ser Ile Asp Val Ser Glu Ile 
            820                 825                 830         


Thr Asn Asp Ile Leu Glu Asp Met Lys Glu Ser Glu Thr Phe Lys Asp 
        835                 840                 845             


Leu Ile Glu Asn Ala Val Asp Ser Asn Glu Lys Ile Ala Gly Met Ala 
    850                 855                 860                 


Asn Asp Ile Lys Gln Ala Asn Asp Glu Leu Glu Gln Gln Ala Lys Asp 
865                 870                 875                 880 


Ile Ala Lys Asn Ala Gln Asp Val Gly Lys Val Gln Thr Ser Val Asn 
                885                 890                 895     


Glu Leu Ser Ser Thr Val Gly Asn Val Ser Ser Ser Leu Ser Gln Leu 
            900                 905                 910         


Glu Gln Thr Val Ala Thr Ala Asp Thr Ala Leu Gly Gln Arg Ile Asp 
        915                 920                 925             


Asn Ile Ser Val Ser Met Asp Gly Met Thr Gly Gly Val Lys Asn Ser 
    930                 935                 940                 


Ala Ile Ala Ile Ile Gln Ala Asn Leu Ala Gln Val Ala Thr Arg Lys 
945                 950                 955                 960 


Thr Leu Ser Ala Ser Val Ala Gly Asn Ser Ala Asn Leu Asp Arg Leu 
                965                 970                 975     


Asp Glu Val Ile Val Ser Glu Lys Glu Ala Thr Ala Arg Ser Leu Leu 
            980                 985                 990         


Ser Leu Gln Thr Asp Val Asn Gly  Asn Lys Ala Ser Ile  Asn Ser Leu 
        995                 1000                 1005             


Asn Gln  Thr Leu Ser Asp Tyr  Gln Gln Ala Thr Ala  Thr Gln Ile 
    1010                 1015                 1020             


Asn Gly  Ile Thr Ala Thr Val  Asn Gly His Thr Ser  Ala Ile Thr 
    1025                 1030                 1035             


Thr Asn  Ala Gln Ala Ile Ala  Asn Val Asn Gly Glu  Leu Ser Ala 
    1040                 1045                 1050             


Met Tyr  Asn Ile Lys Val Gly  Val Ser Ser Asn Gly  Gln Tyr Tyr 
    1055                 1060                 1065             


Ala Ala  Gly Met Gly Ile Gly  Val Glu Asn Thr Pro  Ser Gly Met 
    1070                 1075                 1080             


Gln Ser  Gln Val Ile Phe Leu  Ala Asp Arg Phe Ala  Val Thr Thr 
    1085                 1090                 1095             


Ala Ala  Gly Asn Ser Val Ala  Leu Pro Phe Val Ile  Gln Asn Gly 
    1100                 1105                 1110             


Gln Thr  Phe Ile Arg Ala Ser  Phe Ile Gln Asp Gly  Thr Ile Glu 
    1115                 1120                 1125             


Asn Ala  Lys Ile Gly Asn Tyr  Ile Gln Ser Asn Asn  Tyr Ala Ala 
    1130                 1135                 1140             


Gly Ser  Ala Gly Trp Lys Leu  Asn Lys Ala Gly Asp  Ala Glu Phe 
    1145                 1150                 1155             


Asn Asn  Val Thr Val Arg Gly  Val Val Tyr Ala Ser  Gly Gly Ser 
    1160                 1165                 1170             


Phe Thr  Gly Glu Ile Gln Ala  Thr Ser Gly Lys Phe  Lys Gly Thr 
    1175                 1180                 1185             


Val Glu  Ala Gln Ser Phe Ile  Gly Asp Ile Ala Asn  Met His Thr 
    1190                 1195                 1200             


Gly Thr  Asn Val Ser Arg Ser  Ser Asp Gly Tyr Leu  Glu Lys Val 
    1205                 1210                 1215             


Met Thr  Tyr Asn Asp Ser Ser  Ser Ser Gly His Ala  Arg His Val 
    1220                 1225                 1230             


Cys Val  Ile Ala Asn Val Lys  Gly Asn Gly Ala Gly  Thr Ile Asp 
    1235                 1240                 1245             


Ile Asn  Gly Asn Glu Ser Gly  Ser Ser Val Gln Asp  Met Glu Arg 
    1250                 1255                 1260             


Leu Ile  Met His Ser Ala Val  Val Thr Gly Pro Asn  Val Thr Val 
    1265                 1270                 1275             


Arg Ile  Lys Val Ser Ala Gln  Asn Asn Arg Gly Ala  Ser Ile Ser 
    1280                 1285                 1290             


Ser Pro  Thr Ile Ile Val Ser  His Gly Ser Gly Ser  Phe Thr Gly 
    1295                 1300                 1305             


<210> 1379
<211> 205
<212> PRT
<213> Escherichia coli

<400> 1379
Met Val Lys Thr Leu Ile Leu Glu Gly Lys Met Ala Lys Lys Phe Gly 
1               5                   10                  15      


Lys Arg Val Gln Phe Asp Val Ala Asp Leu Arg Glu Met Leu Arg Ala 
            20                  25                  30          


Met Cys Ser Gln Val Pro Gly Phe Lys Lys Tyr Met Ser Glu Ala His 
        35                  40                  45              


Met Lys Gly Ile Arg Phe Ala Phe Phe Asn Gly Gly Asn Asn Ile Gly 
    50                  55                  60                  


Leu Glu Glu Phe Asp Met Thr Arg Gly Gly Ser Val Tyr Arg Ile Val 
65                  70                  75                  80  


Pro Val Tyr Glu Gly Ala Lys Ser Ser Gly Val Leu Gln Ile Val Val 
                85                  90                  95      


Gly Ala Val Ala Leu Val Ala Ala Phe Phe Thr Ala Gly Ala Ser Met 
            100                 105                 110         


Ala Ala Trp Gly Ala Ala Met Ser Ala Thr Ala Ile Ser Ala Thr Ser 
        115                 120                 125             


Ile Leu Thr Gly Val Gly Val Ser Met Met Leu Gly Gly Val Val Gln 
    130                 135                 140                 


Met Leu Thr Pro Gln Pro Ser Phe Gly Ala Gly Lys Ser Ser Ser Thr 
145                 150                 155                 160 


Asp Asn Thr Pro Asn Tyr Ala Phe Gly Ala Pro Val Asn Thr Val Ala 
                165                 170                 175     


Met Gly His Pro Val Pro Leu Ala Tyr Gly Leu Thr Glu Ala Gly Gly 
            180                 185                 190         


Ala Ile Val Ser Ala Gly Met Tyr Ser Ser Asp Gln Gln 
        195                 200                 205 


<210> 1380
<211> 239
<212> PRT
<213> Escherichia coli

<400> 1380
Met Arg Glu Lys Leu Leu Asp Ala Ile Arg Gln His Val Ala Ala Glu 
1               5                   10                  15      


Tyr Pro Lys Glu Ala Cys Gly Leu Ile Val Gln Ser Gly Gln Gln Gln 
            20                  25                  30          


Ile Phe Ile Pro Cys Arg Asn Ile Ala Asp Lys Pro Glu Glu Thr Phe 
        35                  40                  45              


Thr Leu Ser Pro Glu Asp Gln Leu Ala Ala Arg Ala Arg Gly Glu Ile 
    50                  55                  60                  


Ile Met Leu Ile His Ser His Pro Asp Val Val Arg Leu Val Pro Ser 
65                  70                  75                  80  


Glu Leu Asp Arg Ile Gln Cys Asp Trp Ser Gly Ile Glu Trp Gly Ile 
                85                  90                  95      


Met Ser Trp Pro Asp Gly Asp Phe Cys Thr Ile Ser Pro Arg Glu Asp 
            100                 105                 110         


Arg Asp Tyr Ala Gly Arg Gln Trp Val Leu Gly Tyr Ala Asp Cys Trp 
        115                 120                 125             


Ser Leu Ile Arg Glu Phe Tyr Leu Arg Glu Tyr Gly Ile Val Leu Gly 
    130                 135                 140                 


Asn Tyr Ser Val Pro Tyr Glu Trp Trp Glu Ser Gly Lys Glu Arg Leu 
145                 150                 155                 160 


Tyr Asp Asp Asn Trp Glu Arg Glu Gly Phe Val Glu Ile Ala Ala Gly 
                165                 170                 175     


Ala Met Gln Pro Gly Asp Ile Ile Met Met Ser Val Gln Ala Ser Val 
            180                 185                 190         


Thr Asn His Ala Ala Val Tyr Val Gly Asp Asn Ile Ile Leu His His 
        195                 200                 205             


Leu Phe Gly His Leu Ser Ser Arg Thr Pro Tyr Gly Lys Tyr Tyr Arg 
    210                 215                 220                 


Asp Arg Thr Val Arg Val Val Arg His Lys Asp Arg Met His Gly 
225                 230                 235                 


<210> 1381
<211> 245
<212> PRT
<213> Escherichia coli

<400> 1381
Met Ser Phe Thr Ala Asp Ile Gln Gln Leu Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Gln Leu Ile Glu Ile Asp Gly Thr Glu Phe Gly Met Asp Gln Val Leu 
            20                  25                  30          


Arg Phe His Ala His Asn Ile Gln Glu Glu Gly Trp Ala Ala Phe Ala 
        35                  40                  45              


Ala Glu Asn Leu Pro Ala Ile Ile Trp Gln Gly Asn Gln Tyr Asp Pro 
    50                  55                  60                  


His Pro Tyr Glu Leu Lys Gly Met Glu Leu Ser Ser Thr Gly Ser Gln 
65                  70                  75                  80  


Pro Thr Pro Thr Leu Ser Val Gly Asn Val Gly Asn Tyr Val Thr Ala 
                85                  90                  95      


Leu Cys Leu Glu Tyr Asp Asp Met Val Arg Ala Lys Val Lys Ile His 
            100                 105                 110         


Thr Thr Leu Ser Lys Tyr Leu Asp Ala Ala Asn Trp Lys Asn Gly Asn 
        115                 120                 125             


Pro Gly Ala Ser Pro Ala Asp Glu Arg Leu Gln Leu Phe Tyr Val Asn 
    130                 135                 140                 


Ala Lys Thr Ala Glu Thr Arg Val Gln Val Asp Phe Glu Leu Cys Ser 
145                 150                 155                 160 


Pro Phe Asp Ile Gln Ser Leu Gln Leu Pro Thr Arg Gln Ile Thr Pro 
                165                 170                 175     


Val Cys Thr Trp Cys Met Arg Gly Trp Tyr Arg Ser Gly Thr Gly Cys 
            180                 185                 190         


Asp Tyr Asn Gly Thr Lys Tyr Phe Thr Lys Asp Gly Thr Pro Thr Asp 
        195                 200                 205             


Asp Pro Ser Lys Asp Val Cys Gly Gly Arg Arg Gln Asp Cys Gln Asp 
    210                 215                 220                 


Arg His Gly Pro Asp Ala Pro Leu Pro Phe Gly Gly Phe Pro Ala Ala 
225                 230                 235                 240 


Asn Leu Gln Gly Lys 
                245 


<210> 1382
<211> 112
<212> PRT
<213> Escherichia coli

<400> 1382
Met Thr Asp Thr Phe Thr Trp Arg Thr Arg Lys Thr Ala Gln Gly Thr 
1               5                   10                  15      


Glu Thr Ala Arg Thr Leu Gln Ala Gln Phe Gly Asp Gly Tyr Lys Gln 
            20                  25                  30          


Ile Ala Gly Met Gly Ile Asn Asp Lys Gln Glu Thr Trp Asn Leu Asp 
        35                  40                  45              


Trp Thr Gly Thr Arg Gln Glu Ala Ala Ala Leu Arg Ala Phe Leu Met 
    50                  55                  60                  


Ser His Val Thr Lys Ser Phe Trp Trp Thr Thr Pro Trp Gly Glu Lys 
65                  70                  75                  80  


Lys Leu Phe Arg Met Lys Ala Asp Ser Phe Ser Val Ser Phe Pro Thr 
                85                  90                  95      


Gly Lys Lys Ala Thr Val Ala Phe Thr Phe Glu Gln Ala Phe Ala Pro 
            100                 105                 110         


<210> 1383
<211> 1045
<212> PRT
<213> Escherichia coli

<400> 1383
Met Ala Gln Gln Ile Ser Asp Leu Val Ile Asn Leu Asp Val Asp Ser 
1               5                   10                  15      


Ala Thr Phe Ser Glu Gln Val Ala Arg Ile Lys Gly Gln Leu Thr Gly 
            20                  25                  30          


Met Ala Glu Asp Ser Glu Lys Val Gln Thr Arg Met Gln Arg Ala Ser 
        35                  40                  45              


Glu Arg Gln Ala Ala Ala Phe Lys Thr Val Gly Asp Ala Gly Ala Ala 
    50                  55                  60                  


Ala Ala Ala Asp Met Lys Ser Arg Gln Ser Ala Ala Thr Glu Gly Leu 
65                  70                  75                  80  


Thr Lys Asp Trp Gln Asn Val Ser Lys Ser Val Asp Glu Thr His Arg 
                85                  90                  95      


Arg Val Thr Glu Leu Asn Gln Arg Met Arg Glu Asn Asp Gly Gln Ala 
            100                 105                 110         


Ala Ala Leu Ala Arg Arg Gln Asp Glu Leu Ala Ala Ser Phe Phe Arg 
        115                 120                 125             


Gln Ile Asp Gly Val Arg Gln Leu Asn Gly Glu Thr Gln Ser Leu Ala 
    130                 135                 140                 


Asn Val Gln Ala Arg Phe Arg Ala Ala Arg Ala Gln Gly Asn Ile Thr 
145                 150                 155                 160 


Gln Gln Asp Tyr Leu Ala Leu Ile Ser Arg Thr Thr Ala Arg Gln Lys 
                165                 170                 175     


Glu Leu Gln Ile Val Glu Glu Lys Ser Ala Ala Ala Arg Thr Arg Phe 
            180                 185                 190         


Leu Ser Gln Leu Lys Gln Gln Val Ala Glu Gln Lys Leu Ser Gly Thr 
        195                 200                 205             


Glu Leu Leu Arg Met Lys Ala Ala Gln Val Gly Ala Ser Asp Ala Ala 
    210                 215                 220                 


Glu Val Tyr Ile Arg Lys Leu Glu Ala Ala Lys Val Ala Thr His Gly 
225                 230                 235                 240 


Leu Gly Leu Gln Ser Ala Ala Ala Arg Gln Glu Leu Gly Ile Leu Ile 
                245                 250                 255     


Gly Glu Val Met Arg Gly Asn Phe Gly Ala Leu Arg Gly Ser Gly Ile 
            260                 265                 270         


Thr Leu Ala Asn Arg Ala Gly Trp Ile Asp Gln Leu Leu Ser Leu Arg 
        275                 280                 285             


Gly Leu Gly Ile Ala Ser Met Val Gly Gly Ile Ala Ala Ala Val Phe 
    290                 295                 300                 


Gly Leu Gly Lys Ala Trp Tyr Asp Gly Ser Lys Glu Ser Glu Glu Phe 
305                 310                 315                 320 


Asn Arg Gln Leu Ile Leu Thr Gly Asn Tyr Ala Gly Lys Thr Ser Gly 
                325                 330                 335     


Gln Leu Gln Ala Leu Ala Arg Ser Leu Ala Gly Asn Gly Ile Thr Gln 
            340                 345                 350         


His Ala Ala Ala Gly Val Leu Ala Gln Val Val Gly Ser Gly Ala Phe 
        355                 360                 365             


Ser Gly Asn Asp Val Ser Met Val Ser Asn Val Ala Ala Arg Leu Gln 
    370                 375                 380                 


Gln Ala Thr Gly Gln Ala Val Asp Glu Thr Ile Asn Gln Phe Lys Arg 
385                 390                 395                 400 


Leu Lys Asp Asp Pro Val Asn Ala Val Ala Thr Leu Asn Asp Ser Leu 
                405                 410                 415     


His Phe Leu Thr Ala Thr Gln Tyr Glu Gln Ile Ala Ser Ala Gln Ala 
            420                 425                 430         


Leu Gly Asp Ser Gln Lys Ala Ala Glu Leu Ala Met Arg Ala Tyr Ser 
        435                 440                 445             


Asp Ala Val Ile Gln Arg Ala Gly Ala Val Glu Asp Asn Leu Gly Ser 
    450                 455                 460                 


Leu Glu Lys Ala Trp Asn Trp Val Lys Asn Ala Ala Ser Gly Ala Trp 
465                 470                 475                 480 


Asp Ala Met Leu Gly Val Gly Arg Asn Pro Asp Thr Ala Met Lys Arg 
                485                 490                 495     


Gln Asp Ser Phe Ala Glu Trp Gln Ala Ala Glu Lys Glu Tyr Arg Ala 
            500                 505                 510         


Leu Ser Ser Asn Leu Lys Val Asp Pro Asp Tyr Ala Gly Asn Asn Val 
        515                 520                 525             


Leu Gln Lys Ala Asp Ala Glu Arg Leu Arg Asn Ala Arg Gln Gln Val 
    530                 535                 540                 


Glu Leu Lys Lys Gln Ala Tyr Asp Leu Ala Asp Gln Gln Tyr Ala Gln 
545                 550                 555                 560 


Glu Gly Leu Ala Ala Ala Arg Glu Lys Met Arg Thr Asp Gln Gln Ala 
                565                 570                 575     


Gln Ala Ile Arg Ser Gln Gln Gln Phe Asn Gln Leu Val Glu Ser Gly 
            580                 585                 590         


Ala Thr Ala Ala Glu Lys Arg Ala Ser Ala Glu Lys Lys Leu Ser Gln 
        595                 600                 605             


Leu Ile Glu Lys Asn Arg Gln Asp Ala Lys Asp Gly Val Ala Thr Leu 
    610                 615                 620                 


Trp Thr Glu Lys Asp Ile Ala Ala Ala Arg Ala Gly Ile Glu Lys Gln 
625                 630                 635                 640 


Trp Lys Asp Pro Lys Thr Pro Lys Gly Lys Ser Tyr Ser Thr Pro Ala 
                645                 650                 655     


Gly Asp Lys Ala Glu Glu Lys Ala Gln Ala Glu Leu Leu Thr Leu Gln 
            660                 665                 670         


Ala Gln Leu Lys Thr Leu Glu Gln His Thr Ser Val Asn Asp Val Ile 
        675                 680                 685             


Ser Lys Gln Arg Gln Asp Leu Trp Gln Thr Glu Asn Gln Phe Thr Val 
    690                 695                 700                 


Leu Gln Glu Ala Ala Gly Arg Arg Gln Leu Thr Ala Gln Glu Lys Ser 
705                 710                 715                 720 


Leu Leu Ala His Lys Glu Glu Thr Leu Glu Tyr Lys Arg Gln Leu Ala 
                725                 730                 735     


Asp Leu Gly Asp Lys Val Ala Ser Gln Gln Lys Leu Asn Gln Leu Ala 
            740                 745                 750         


Asp Gln Ala Val Lys Phe Glu Gln Gln Gln Lys Ala Ala Arg Ala Gly 
        755                 760                 765             


Leu Gln Ala Gln Ser Glu Gly Leu Ser Thr Arg Glu Ala Gly Arg Gln 
    770                 775                 780                 


Thr Thr Leu Gln Arg Leu Ser Glu Ser Tyr Ser Tyr Asn Pro Gln Ala 
785                 790                 795                 800 


Gln Gln Lys Val Leu Glu Glu Gln Arg Ala Thr Phe Glu Ala Glu Asp 
                805                 810                 815     


Ala Leu Arg Ala Asn Trp Leu Ala Gly Ala Lys Gln Gly Trp Ala Glu 
            820                 825                 830         


Tyr Gln Asp Ser Ala Thr Asn Val Phe Ser Ser Val Gln Gln Ile Ser 
        835                 840                 845             


Gln Ala Thr Phe Ser Gly Leu Ala Gly Gln Leu Thr Ser Leu Thr Thr 
    850                 855                 860                 


Thr Gly Lys Ala Ser Phe Arg Glu Phe Thr Ser Ser Ile Leu Lys Met 
865                 870                 875                 880 


Ile Val Ser Val Ile Asn Gln Leu Leu Val Ala Tyr Thr Ile Gln Ser 
                885                 890                 895     


Ala Met Gly Trp Val Ser Gly Gly Ala Lys Thr Ser Ser Ala Gly Gln 
            900                 905                 910         


Ser Phe Ala Val Pro Ser Tyr Arg Pro Gln Gly Phe Asp Val Gly Gly 
        915                 920                 925             


Phe Thr Gly His Gly Gly Lys Tyr Glu Pro Ala Gly Ile Val His Arg 
    930                 935                 940                 


Gly Glu Phe Val Phe Thr Lys Glu Ser Thr Ser Arg Ile Gly Val Ala 
945                 950                 955                 960 


Asn Leu Tyr Arg Leu Met Arg Gly Tyr Ala Ser Gly Gly Leu Val Gly 
                965                 970                 975     


Gly Gly Asn Ala Ala Gly Ala Gly Met Gly Gly Ile Ser Val Tyr Ala 
            980                 985                 990         


Pro Val Ser Ile Ser Gln Gln Gly  Ser Asp Gly Ser Ile  Asn Gln Ala 
        995                 1000                 1005             


Asn Ala  Thr Gly Thr Ala Lys  Gln Leu Gln Ala Ile  Val Gln Gln 
    1010                 1015                 1020             


Thr Ile  Thr Glu Arg Leu Lys  Lys Glu Met Ser Ala  Gly Gly Val 
    1025                 1030                 1035             


Leu Tyr  Ser Arg Arg Thr Gln  
    1040                 1045 


<210> 1384
<211> 90
<212> PRT
<213> Escherichia coli

<400> 1384
Met Leu Ala Gly Met Thr Ser Thr Glu Leu Gly Asp Trp His Gln Phe 
1               5                   10                  15      


Tyr Arg Glu His Tyr Phe Gln Asp Ala Gln Leu Asp Ala His Phe Ser 
            20                  25                  30          


Glu Leu Leu Tyr Ser Ile Ser Thr Leu Phe Phe Arg Asp Pro Glu Leu 
        35                  40                  45              


Thr Pro Ala His Phe Ser Leu Leu Ser Pro Ser Gly Ile Val Ile Ser 
    50                  55                  60                  


Asp Asp Glu Pro Asp Asp Asp Ala Leu Met Ala Ala Ala Glu Gly Ile 
65                  70                  75                  80  


Thr Gly Gly Ile Arg Tyr Gly Pro Ala Asp 
                85                  90  


<210> 1385
<211> 143
<212> PRT
<213> Escherichia coli

<400> 1385
Met Phe Leu Lys Lys Glu Lys Phe Thr Trp Gln Lys Glu Ser Leu Thr 
1               5                   10                  15      


Ile Phe Glu Leu Ser Ala Leu Gln Arg Ile Glu Tyr Ile Thr Phe Met 
            20                  25                  30          


Ala Ala Glu Glu Lys Ala Val Ser Ala Asp Ser Asp Gly Ile Ser Asp 
        35                  40                  45              


Gln Glu Met Thr Ala Arg Leu Ile Gly Ser Asn Ile Arg Cys Gly Ala 
    50                  55                  60                  


Arg Leu Ile Ala Met Ser Leu Trp His Asn Asp Pro Ala Gly Thr Asp 
65                  70                  75                  80  


Val Glu Thr Leu Tyr Gln Gln Val Leu Ser Gly Trp Pro Pro Glu Ala 
                85                  90                  95      


Ile Gly Lys Ala Glu Met Glu Ile Lys Leu Leu Ser Gly Met Leu Val 
            100                 105                 110         


Pro Val Glu Asp Asp Lys Ala Ala Asp Pro Asp Ala Pro Ala Glu Ala 
        115                 120                 125             


Glu Ser Ala Glu Pro Val Ala Ala Glu Lys Pro Leu Pro Ala Ser 
    130                 135                 140             


<210> 1386
<211> 247
<212> PRT
<213> Escherichia coli

<400> 1386
Met Pro Thr Pro Asn Pro Leu Ala Pro Val Lys Gly Ala Gly Thr Thr 
1               5                   10                  15      


Leu Trp Leu Tyr Thr Gly Thr Gly Asn Ala Phe Ala Asn Pro Leu Ser 
            20                  25                  30          


Asp Ile Asp Trp Asn Arg Leu Ala Lys Ile Lys Glu Leu Thr Pro Gly 
        35                  40                  45              


Glu Met Thr Ala Glu Ser Tyr Asp Asp Thr Tyr Leu Asp Asp Glu Asp 
    50                  55                  60                  


Ala Asp Trp Asn Ala Thr Ala Gln Gly Ala Lys Ser Ala Gly Asp Thr 
65                  70                  75                  80  


Ser Phe Thr Leu Ala Trp Lys Pro Gly Glu Glu Gly Gln Lys Asp Leu 
                85                  90                  95      


Val Ala Trp Phe Ile Asp Gly Ser Val Arg Tyr Tyr Lys Ile Lys Tyr 
            100                 105                 110         


Pro Asn Gly Thr Val Asp Val Phe Arg Gly Trp Cys Ser Ser Leu Gly 
        115                 120                 125             


Lys Ala Ile Pro Ala Lys Glu Val Ile Thr Arg Thr Ala Lys Ile Thr 
    130                 135                 140                 


Asn Thr Gly Lys Pro Glu Leu Ala Glu Glu Ser Gly Thr Pro Asn Ile 
145                 150                 155                 160 


Pro Val Thr Gly Val Thr Leu Asp Lys Ala Thr Ala Ser Val Ala Val 
                165                 170                 175     


Gly Ala Thr Thr Thr Leu Asn Val Thr Val Asn Pro Ala Ser Ala Ser 
            180                 185                 190         


Asp Thr Ser Phe Arg Val Ala Thr Ser Asp Gly Ala Lys Ala Thr Val 
        195                 200                 205             


Thr Val Ser Gly Asn Ala Ile Thr Val Thr Gly Val Ala Ala Gly Thr 
    210                 215                 220                 


Ala Asp Val Ile Val Met Thr Ser Asp Gly Asn Phe Val Ala Val Cys 
225                 230                 235                 240 


Lys Val Thr Val Thr Ala Ala 
                245         


<210> 1387
<211> 133
<212> PRT
<213> Escherichia coli

<400> 1387
Met Asn Arg His Ser Ala Ile Arg Ala Ala Ile Leu Ala Lys Leu Lys 
1               5                   10                  15      


Ala Glu Ile Thr Asp Thr Val Thr Trp Phe Asp Gly Arg Pro Val Phe 
            20                  25                  30          


Leu Glu Glu Gln Asp Leu Pro Ala Val Ala Val Tyr Leu Ser Asp Ala 
        35                  40                  45              


Glu Tyr Thr Gly Asp Ser Leu Asp Glu Asp Ser Trp Gln Ala Val Val 
    50                  55                  60                  


His Ile Glu Val Phe Leu Lys Ala Ser Ser Pro Asp Ser Ala Leu Asp 
65                  70                  75                  80  


Ser Trp Met Glu Glu Lys Val Tyr Pro Ala Met Ala Phe Ile Pro Gly 
                85                  90                  95      


Leu Thr Glu Leu Val Glu Thr Phe Thr Pro Gln Gly Tyr Asp Tyr Gln 
            100                 105                 110         


Arg Asp Asp Glu Met Ala Thr Trp Gly Ser Val Asp Phe Thr Tyr Leu 
        115                 120                 125             


Ile Thr Tyr Ser Ile 
    130             


<210> 1388
<211> 190
<212> PRT
<213> Escherichia coli

<400> 1388
Met Lys Gly Leu Glu Arg Ala Ile Gln Asn Leu Asn Ser Leu Ser Arg 
1               5                   10                  15      


Leu Ile Val Pro Glu Ala Thr Ala Lys Ala Leu Asn Arg Val Ala Arg 
            20                  25                  30          


Arg Thr Ile Ser Gln Gly Ser Lys Ala Val Ala Lys Glu Ala Thr Val 
        35                  40                  45              


Asp Asp Asn Arg Lys Lys Gly Leu Pro Val Arg Leu Val Arg Gln Arg 
    50                  55                  60                  


Ser Arg Leu Arg Lys Ala Arg His Asp Arg Pro Val Ala Ser Ile Lys 
65                  70                  75                  80  


Ile Asn Arg Gly Asn Leu Pro Ala Ile Lys Leu Gly Thr Ala Arg Val 
                85                  90                  95      


Arg Leu Ser Arg Lys Lys Gly Ala Arg Asn Gly Ala Gly Ser Val Leu 
            100                 105                 110         


Lys Ile Gly Pro Tyr Thr Phe Arg Asn Ala Phe Ile Gln Gln Leu Ala 
        115                 120                 125             


Asn Gly Arg Trp Gln Val Met Arg Arg Val Gly Gln Ala Arg Tyr Pro 
    130                 135                 140                 


Ile Asp Val Val Lys Val Pro Leu Glu Thr Pro Leu Thr Val Ala Phe 
145                 150                 155                 160 


Thr Ala Ile Ser Lys Arg Leu Ile Glu Ser Asp Met Pro Lys Glu Leu 
                165                 170                 175     


Ser Ala Ala Leu Lys Asn Gln Leu Arg Ile His Leu Lys Arg 
            180                 185                 190 


<210> 1389
<211> 80
<212> PRT
<213> Escherichia coli

<400> 1389
Met Asp Ala Ala Thr Ile Lys Lys Met Gly Lys Thr Ala Ile Ile Asn 
1               5                   10                  15      


Gly Ser Ser Tyr Asp Val Val Pro Ala Glu Gln Leu Glu Glu Met Gly 
            20                  25                  30          


Pro Leu Ser Gly Thr Gly Thr Ser Leu Val Val Phe Ser Glu Leu Tyr 
        35                  40                  45              


Gln Pro Arg Arg Asn Asp Ser Val Asp Tyr Asp Gly Lys Asn Leu Ile 
    50                  55                  60                  


Val Thr Arg Tyr Asp Met Phe Asn Gly Lys Pro Arg Ile His Leu Glu 
65                  70                  75                  80  


<210> 1390
<211> 108
<212> PRT
<213> Escherichia coli

<400> 1390
Met Ala Lys Asn Tyr Ala Gln Asp Gly Lys Thr Ile Pro Leu Val Asn 
1               5                   10                  15      


Ser Gly Ala Thr Asp Val His Ser Gly Asp Pro Val Val Val Gly Lys 
            20                  25                  30          


Leu Ile Ala Val Ala Ile Thr Asp Ile Pro Ala Gly Asp Thr Gly Asp 
        35                  40                  45              


Gly Phe Thr Glu Gly Val Phe Leu Leu Pro Lys Val Ser Ala Asp Ala 
    50                  55                  60                  


Val Thr Ala Gly Ala Gln Val Tyr Leu Lys Asp Gly Lys Ile Thr Ile 
65                  70                  75                  80  


Glu Glu Thr Asp Ala Val Ala Ala Gly Ile Ala Trp Glu Asp Ala Gly 
                85                  90                  95      


Ala Asn Thr Thr Val Val Glu Val Lys Ile Asn Ala 
            100                 105             


<210> 1391
<211> 648
<212> PRT
<213> Escherichia coli

<400> 1391
Met Gln Ala Ser Asn Asn Ser Glu Ala Asp Ile Phe Ile Tyr Asp Glu 
1               5                   10                  15      


Ile Gly Tyr Trp Gly Val Thr Ala Lys Gln Phe Val Asn Asp Leu Arg 
            20                  25                  30          


Ala Leu Gly Asp Val Thr His Ile Asn Leu Tyr Ile Asn Ser Pro Gly 
        35                  40                  45              


Gly Asp Val Phe Asp Gly Ile Ala Ile Tyr Asn Ala Leu Lys His His 
    50                  55                  60                  


Gly Ala Ala Ile Thr Val His Ile Asp Gly Leu Ala Ala Ser Met Ala 
65                  70                  75                  80  


Ser Val Ile Ala Met Val Gly Asn Pro Val Ile Met Pro Glu Asn Thr 
                85                  90                  95      


Met Met Met Ile His Lys Pro Trp Gly Phe Ala Gly Gly Asp Ala Ser 
            100                 105                 110         


Asp Met Arg Asp Tyr Ala Asp Leu Leu Asp Lys Val Glu Ser Val Leu 
        115                 120                 125             


Ile Pro Ala Tyr Ala Gln Lys Thr Gly Lys Ser Thr Glu Glu Ile Ala 
    130                 135                 140                 


Val Met Leu Glu Asp Glu Thr Trp Met Asn Gly Ser Glu Cys Leu Glu 
145                 150                 155                 160 


Leu Gly Phe Ala Asp Gln Val Thr Pro Ser Leu Gln Ala Met Ala Cys 
                165                 170                 175     


Ile His Ser Lys Arg Ile Glu Glu Phe Glu Lys Met Pro Lys Ser Ile 
            180                 185                 190         


Arg Asn Met Ile Thr Pro Pro Arg Asn Thr Thr Gln Arg Asp Pro Val 
        195                 200                 205             


Ile Thr Gln Pro Gln Ala Pro Gln Ala Lys Thr Asp Pro Ala Pro Asp 
    210                 215                 220                 


Glu Asn Ala Ile Arg Ala Gln Val Leu Ala Glu Gln Lys Thr Arg Val 
225                 230                 235                 240 


Asn Ala Ile Gly Asp Leu Phe Ala Met Phe Gly Asn Lys His Met Glu 
                245                 250                 255     


Leu Gln Asn Gln Cys Val Ala Asp Pro Asp Cys Ser Val Asp Lys Ala 
            260                 265                 270         


Lys Asp Leu Leu Leu Ala Glu Leu Gly Lys Thr Ala Thr Pro Ser Asn 
        275                 280                 285             


Lys Thr Thr Gln Pro His Ile His Ala Gly Asn Gly Asn Phe Val Ala 
    290                 295                 300                 


Asp Gly Ile Arg Gln Ala Leu Met Ala Arg Ala Gly Phe Glu Gly Gln 
305                 310                 315                 320 


Glu Arg Asp Asn Val Tyr Asn Gly Met Thr Leu Arg Glu Tyr Ala Arg 
                325                 330                 335     


Met Ala Leu Thr Glu Lys Gly Ile Gly Val Ala Ser Tyr Asn Pro Met 
            340                 345                 350         


Gln Met Val Gly Leu Ala Leu Thr His Ser Thr Ser Asp Phe Gly Asn 
        355                 360                 365             


Ile Leu Leu Asp Val Ala Asn Lys Ala Leu Ile Gln Gly Trp Asp Glu 
    370                 375                 380                 


Ala Gln Glu Thr Phe Glu Gln Trp Thr Lys Lys Gly Gln Leu Ser Asp 
385                 390                 395                 400 


Phe Lys Thr Ala His Arg Val Gly Met Gly Gly Phe Pro Ser Leu Arg 
                405                 410                 415     


Gln Val Arg Glu Gly Ala Glu Tyr Lys Tyr Ile Thr Thr Ser Asp Lys 
            420                 425                 430         


Gly Glu Thr Ile Ala Leu Ala Thr Tyr Gly Glu Ile Phe Ser Val Thr 
        435                 440                 445             


Arg Gln Ala Ile Ile Asn Asp Asp Leu Asn Gln Leu Thr Asp Val Pro 
    450                 455                 460                 


Met Lys Met Gly Arg Ala Ala Lys Ala Thr Ile Gly Asp Leu Val Tyr 
465                 470                 475                 480 


Ala Ile Leu Thr Lys Asn Pro Lys Leu Ser Asp Gly Lys Ala Leu Phe 
                485                 490                 495     


His Ala Asp His Lys Asn Leu Ser Ser Gly Ala Ile Ser Val Ala Ser 
            500                 505                 510         


Leu Asp Glu Ser Arg Lys Leu Met Arg Leu Gln Lys Glu Gly Glu Arg 
        515                 520                 525             


Thr Leu Asn Ile Arg Pro Ala Tyr Met Leu Val Pro Val Ala Leu Glu 
    530                 535                 540                 


Thr Leu Ala Asn Gln Thr Ile Lys Ser Ala Ser Val Lys Gly Ala Asp 
545                 550                 555                 560 


Ile Asn Ala Gly Ile Val Asn Pro Ile Gln Asn Phe Ala Glu Val Ile 
                565                 570                 575     


Ala Glu Pro Arg Leu Asp Glu Ala Asp Ala Lys Ala Trp Tyr Leu Ala 
            580                 585                 590         


Ala Ala Lys Gly Thr Asp Thr Ile Glu Val Ala Tyr Leu Asn Gly Val 
        595                 600                 605             


Asp Thr Pro Tyr Ile Asp Gln Gln Glu Gly Phe Thr Thr Asp Gly Ile 
    610                 615                 620                 


Ala Thr Lys Val Arg Ile Asp Ala Gly Val Ala Pro Leu Asp Tyr Arg 
625                 630                 635                 640 


Gly Met Thr Lys Ser Ser Gly Gln 
                645             


<210> 1392
<211> 499
<212> PRT
<213> Escherichia coli

<400> 1392
Met Ser Phe Leu Asp Asp Ala Ile Gly Leu Phe Ser Pro Gly Trp Lys 
1               5                   10                  15      


Ala Ser Arg Leu Arg Ala Arg Ala Val Ile Lys Ala Tyr Glu Ala Val 
            20                  25                  30          


Lys Gln Thr Arg Thr His Lys Ala Gln Lys Glu Asn Arg Ser Ala Asp 
        35                  40                  45              


Gln Leu Ser Gln Met Gly Ala Val Ser Leu Arg Gln Gln Ala Arg Trp 
    50                  55                  60                  


Leu Asp Asn Asn His Asp Leu Val Ile Gly Val Phe Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Arg Val Val Gly Ala Lys Gly Ile Ile Val Glu Pro His Pro Met 
                85                  90                  95      


Leu Ser Asn Gly Lys Ile Ala Lys Lys Leu Ala Thr Asp Ile Arg Arg 
            100                 105                 110         


Lys Trp Gly Glu Trp Ser Val Arg Pro Asp Val Thr Thr Gln Phe Thr 
        115                 120                 125             


Arg Pro Met Leu Glu Arg Leu Met Leu Arg Thr Trp Leu Arg Asp Gly 
    130                 135                 140                 


Glu Val Phe Ala Gln Leu Val Arg Gly Thr Gly Asn Gly Leu Gln Pro 
145                 150                 155                 160 


Val Ala Gly Val Pro Phe Trp Leu Glu Ala Leu Glu Pro Asp Phe Val 
                165                 170                 175     


Pro Met Asn Ser Asp Ala Ala Thr Gln Leu Asn Gln Gly Val Phe Val 
            180                 185                 190         


Asp Asn Trp Gly Arg Pro Lys Lys Tyr Gln Val Tyr Lys Ser Leu Pro 
        195                 200                 205             


Val Ser Gly Arg Gln Phe Asp Thr Lys Glu Ile Asp Ala Glu Asn Met 
    210                 215                 220                 


Leu His Leu Lys Phe Thr Arg Arg Leu His Gln Thr Arg Gly Thr Ser 
225                 230                 235                 240 


Leu Leu Ser Gly Val Leu Met Arg Leu Ser Ala Leu Lys Glu Tyr Glu 
                245                 250                 255     


Asp Ser Glu Leu Thr Ala Ala Arg Ile Ala Ala Ala Leu Gly Met Tyr 
            260                 265                 270         


Ile Lys Lys Gly Asp Gly Gln Ser Phe Asp Ser Asp Ser Ser Ser Asp 
        275                 280                 285             


Asp Arg Glu Leu Met Ile Gln Pro Gly Met Leu Tyr Asp Glu Leu Gln 
    290                 295                 300                 


Ala Gly Glu Glu Ile Gly Met Ile Lys Ser Asp Arg Pro Asn Pro Asn 
305                 310                 315                 320 


Leu Glu Ser Phe Arg Asn Gly Gln Leu Arg Ala Val Ser Ala Gly Ser 
                325                 330                 335     


Arg Leu Ser Phe Ser Ser Thr Ser Arg Asn Tyr Asn Gly Thr Tyr Ser 
            340                 345                 350         


Ala Gln Arg Gln Glu Leu Val Glu Ser Thr Asp Gly Tyr Leu Ile Leu 
        355                 360                 365             


Gln Asp Trp Phe Ile Gly Ser Val Thr Arg Pro Met Tyr Arg Ala Trp 
    370                 375                 380                 


Leu Lys Met Ala Ile Ala Ala Gly Glu Ile Lys Leu Pro Arg Gly Ile 
385                 390                 395                 400 


Asp Met Asp Ser Leu Tyr Asn Ala Val Tyr Ser Gly Pro Val Met Pro 
                405                 410                 415     


Trp Ile Asp Pro Val Lys Glu Ala Asn Ala Trp Lys Thr Gln Ile Arg 
            420                 425                 430         


Gly Gly Ala Ala Thr Glu Ser Asp Trp Ile Arg Ala Ser Gly Arg Asn 
        435                 440                 445             


Pro Asp Asp Val Lys Ser Arg Arg Lys Ala Glu Val Asp Glu Asn Arg 
    450                 455                 460                 


Glu Gln Gly Leu Val Phe Asp Thr Asp Pro Ala Asn Asp Lys Gly Gly 
465                 470                 475                 480 


Thr Ser Ala Glu Ala Lys Glu Pro Gly Ala Pro Pro Ser Glu Ser Gln 
                485                 490                 495     


Arg Lys Lys 
            


<210> 1393
<211> 71
<212> PRT
<213> Escherichia coli

<400> 1393
Met Asn Pro Ala Asp Ile Gln Asn Met Ile Asp Arg Tyr Ala Ala Ala 
1               5                   10                  15      


Glu Leu Ser Val Leu Glu Gly Lys Ser Ile Thr Phe Asn Gly Gln Gln 
            20                  25                  30          


Met Thr Leu Glu Asn Leu Ser Glu Ile Arg Lys Gly Arg Gln Glu Trp 
        35                  40                  45              


Glu Arg Arg Leu Ala Thr Leu Asn Asn Lys Arg Arg Gly Arg Pro Gly 
    50                  55                  60                  


Tyr Arg Leu Ala Arg Phe Gly 
65                  70      


<210> 1394
<211> 700
<212> PRT
<213> Escherichia coli

<400> 1394
Met Ala Lys Arg Ala Ser Ala Arg Asp Ile Arg Arg Asp Val Ser Gly 
1               5                   10                  15      


Ile Leu Arg Ala Pro Arg Arg Met Pro Val Ala Asp Ala Val Ser Thr 
            20                  25                  30          


Tyr Met Arg Val Pro Met Gly Ala Gly Asn Ser Val Pro Trp Asp Pro 
        35                  40                  45              


Asp Leu Ala Pro Tyr Val Ile Glu Pro Met Asn Cys Leu Ala Ser Arg 
    50                  55                  60                  


Glu Tyr Asp Ala Val Val Phe Val Gly Pro Ala Arg Thr Gly Lys Thr 
65                  70                  75                  80  


Ile Gly Leu Ile Asp Gly Trp Ile Val Tyr Asn Ile Val Cys Asp Pro 
                85                  90                  95      


Ala Asp Met Leu Val Ile Gln Val Ser Glu Glu Lys Ala Arg Glu His 
            100                 105                 110         


Ser Lys Lys Arg Leu Asp Arg Thr Phe Arg Cys Ser Pro Glu Val Lys 
        115                 120                 125             


Thr Arg Leu Ser Pro Arg Arg Asn Asp Asn Asn Val Tyr Asp Arg Thr 
    130                 135                 140                 


Phe Arg Ala Gly Asn Tyr Leu Lys Leu Gly Trp Pro Ser Val Asn Ile 
145                 150                 155                 160 


Met Ser Ser Ser Asp Tyr Lys Ser Val Ala Leu Thr Asp Tyr Asp Arg 
                165                 170                 175     


Phe Pro Glu Asp Ile Asp Gly Glu Gly Asp Ala Phe Ser Leu Ala Ser 
            180                 185                 190         


Lys Arg Thr Thr Thr Phe Met Ser Ser Gly Met Thr Leu Val Glu Ser 
        195                 200                 205             


Ser Pro Gly Arg Asp Ile Arg Asp Thr Lys Trp Arg Arg Ser Thr Pro 
    210                 215                 220                 


His Glu Ala Pro Pro Thr Thr Gly Ile Leu Ser Leu Tyr Asn Arg Gly 
225                 230                 235                 240 


Asp Arg Arg Arg Leu Tyr Trp Pro Cys Pro His Cys Gly Glu Tyr Phe 
                245                 250                 255     


Gln Pro Glu Met Asp Asn Met Thr Gly Tyr Arg Asp Ser Ser Asp Pro 
            260                 265                 270         


Val Leu Ala Ser Glu Ala Ala Phe Leu Gln Cys Pro Ala Cys Lys Gly 
        275                 280                 285             


Arg Ile Thr Pro Asp Met Lys Arg Ala Leu Asn Met Lys Cys Val Trp 
    290                 295                 300                 


Leu Arg Asp Gly Gln Thr Ile Asp Arg Lys Gly Leu Val Ser Gly Asp 
305                 310                 315                 320 


Gly Arg Arg Ser Arg Ile Ala Ser Phe Trp Met Glu Gly Pro Ala Ala 
                325                 330                 335     


Ala Tyr Gln Thr Trp Ala Gln Leu Ile Tyr Lys Phe Leu Thr Ala Glu 
            340                 345                 350         


Gln Glu Tyr Glu Ser Thr Arg Ser Glu Glu Thr Leu Lys Thr Val Ile 
        355                 360                 365             


Asn Thr Asp Phe Gly Arg Pro Tyr Leu Pro Arg Ala Ser Met Glu Gln 
    370                 375                 380                 


Arg Lys Ser Glu Leu Leu Glu Gln Arg Ala Glu Asp Val Pro Lys Arg 
385                 390                 395                 400 


Ser Val Pro Asn Gly Val Gln Phe Leu Thr Ala Thr Val Asp Val Gln 
                405                 410                 415     


Ala Gly Arg Asn Arg Arg Phe Val Val Gln Ile Thr Gly Tyr Gly Ser 
            420                 425                 430         


Met Gly Glu Arg Trp Ile Val Asp Arg Tyr Asn Ile Arg His Ser Leu 
        435                 440                 445             


Arg Cys Asp Gly Asn Gly Glu Ser Ile Gln Val Asp Pro Ala Ser Tyr 
    450                 455                 460                 


Pro Glu Asp Trp Asp Leu Leu Leu Thr Asp Val Phe Asp Lys Thr Trp 
465                 470                 475                 480 


Pro Leu Ala Ala Asp Pro Ser Lys Gly Met Arg Leu Met Ser Met Ala 
                485                 490                 495     


Val Asp Ser Gly Gly Glu Asp Gly Val Thr Asp Asn Ala Tyr Lys Phe 
            500                 505                 510         


Trp Arg Arg Cys Arg Arg Glu Gly Leu Gly Lys Arg Ile Tyr Leu Phe 
        515                 520                 525             


Lys Gly Asp Ser Val Arg Arg Ser Lys Leu Ile Gln Arg Thr Phe Pro 
    530                 535                 540                 


Asp Asn Thr Gly Arg Ser Thr Arg Arg Ala Gln Ala Thr Gly Asp Val 
545                 550                 555                 560 


Pro Leu Tyr Leu Leu Gln Thr Asp Ala Leu Lys Asp Arg Val Asn Asn 
                565                 570                 575     


Ala Leu Trp Arg Asp Ser Pro Gly Pro Gly Tyr Val His Phe Pro Ala 
            580                 585                 590         


Trp Leu Gly Ser Trp Phe Tyr Asp Glu Leu Thr Tyr Glu Glu Arg Ser 
        595                 600                 605             


Asn Glu Gly Lys Trp Ser Lys Pro Gly Arg Gly Ala Asn Glu Ala Phe 
    610                 615                 620                 


Asp Leu Leu Val Tyr Ala Asp Ala Leu Ala Ile Leu Ser Gly Tyr Glu 
625                 630                 635                 640 


Lys Ile Lys Trp Pro Ser Ala Pro Glu Trp Ala Arg Arg Glu Thr Trp 
                645                 650                 655     


Ile Glu Asp Thr Gln Thr Glu Ala Gly Glu Met Pro Ser Pro Pro Pro 
            660                 665                 670         


Ala Pro Lys Ser Lys Pro Lys Pro Lys Arg Glu Lys Pro Val Thr Glu 
        675                 680                 685             


Gln Ala Asn Pro Trp Ser Ser Ser Gly Gly Trp Val 
    690                 695                 700 


<210> 1395
<211> 162
<212> PRT
<213> Escherichia coli

<400> 1395
Met Asp Gln Glu Ile Ala Thr Leu Lys Leu Asn Ile Asn Gln Leu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Val His Arg Gln Thr Val Ala Ala Arg Leu Lys Asn 
            20                  25                  30          


Val Glu Pro Ala Pro Gly Ser Asn Ser Lys Leu Lys Leu Tyr Leu Val 
        35                  40                  45              


Thr Asp Ile Leu Thr Glu Leu Met Ile Pro Thr Val Ser Ala Asn Ile 
    50                  55                  60                  


Asp Asp Met Pro Pro Ser Asp Arg Leu Ser His Trp Lys Ala Glu Asn 
65                  70                  75                  80  


Glu Arg Leu Lys Phe Glu Gln Asp Thr Gly Gln Leu Ile Pro Ala Asp 
                85                  90                  95      


Glu Val Ala Arg Glu Phe Ser Leu Met Ala Lys Ala Val Val Met Val 
            100                 105                 110         


Leu Glu Thr Leu Pro Asp Val Leu Glu Arg Asp Cys Ala Leu Thr Pro 
        115                 120                 125             


Ala Ala Val Val Arg Val Gln Ser Val Ile Asp Asp Leu Arg Asp Gln 
    130                 135                 140                 


Met Ala Glu Lys Val Gln Asp Ala Gly Lys Glu Glu Glu Gln Pro Glu 
145                 150                 155                 160 


Glu Asp 
        


<210> 1396
<211> 242
<212> PRT
<213> Escherichia coli

<400> 1396
Met Ser Asn Lys Ile Ile Thr Leu Ser Gly Ala Ala Asn Glu Val Leu 
1               5                   10                  15      


Tyr Ala Leu Phe Phe Arg Gly Ala Leu Leu Ser Gly Asp Leu Pro Ser 
            20                  25                  30          


Lys Ser Gly Thr Ala Glu Leu Arg Glu Leu Gly Phe Ala Glu Thr Arg 
        35                  40                  45              


His Thr Ala Thr Glu Tyr Gln Lys Glu Asn His Phe Thr Phe Leu Thr 
    50                  55                  60                  


Ser Glu Gly Gln Lys Phe Ala Val Glu His Leu Val Asn Thr Arg Phe 
65                  70                  75                  80  


Gly Glu Gln Gln Tyr Cys Ala Ser Met Thr Leu Gly Val Glu Ile Asp 
                85                  90                  95      


Thr Ser Ala Ala Gln Lys Ala Ile Asp Glu Leu Asp Gln Arg Ile Arg 
            100                 105                 110         


Asp Thr Val Ser Phe Glu Leu Ile Arg Asn Gly Val Ser Phe Ile Lys 
        115                 120                 125             


Asp Ala Ala Ile Ala Asn Gly Ala Ile His Ala Ala Ala Ile Glu Thr 
    130                 135                 140                 


Pro Gln Pro Val Thr Asn Ile Tyr Asn Ile Ser Leu Gly Ile Gln Arg 
145                 150                 155                 160 


Asp Glu Pro Ala Gln Asn Lys Val Thr Val Ser Ala Asp Lys Phe Lys 
                165                 170                 175     


Val Lys Pro Gly Val Asp Thr Asn Ile Glu Thr Leu Ile Glu Asn Ala 
            180                 185                 190         


Leu Lys Asn Ala Ala Glu Cys Ala Ala Leu Asp Val Thr Lys Gln Met 
        195                 200                 205             


Ala Ala Asp Lys Lys Ala Met Asp Glu Leu Ala Ser Tyr Val Arg Thr 
    210                 215                 220                 


Ala Ile Met Met Glu Cys Phe Pro Gly Gly Val Ile Trp Gln Gln Cys 
225                 230                 235                 240 


Arg Arg 
        


<210> 1397
<211> 76
<212> PRT
<213> Escherichia coli

<400> 1397
Met Lys Ile Leu Ala Phe Ile Asn Pro Pro Gly Ser Tyr Met Gln Ile 
1               5                   10                  15      


Glu Thr Lys Glu Met Val Ile Phe Leu Arg Asp Asp Gly Ile Ser Leu 
            20                  25                  30          


Gln Tyr Pro Asp Gly Gln Cys Ala Gly Tyr Gly Ile Asp Gly Asn Met 
        35                  40                  45              


Leu Ile Phe Met Gly Gln Ser Cys Glu Leu Phe Pro Thr Lys Ile Ile 
    50                  55                  60                  


Leu His Asp Gln Arg Thr Thr Asn Phe Thr His Lys 
65                  70                  75      


<210> 1398
<211> 198
<212> PRT
<213> Escherichia coli

<400> 1398
Met Asp Tyr Tyr His Glu Ile Asp Phe Pro Ser Leu Phe Ala Arg Ala 
1               5                   10                  15      


Val Glu Ser Asp Asp Asp Val Gly Thr Thr Leu Arg Ile His Leu Leu 
            20                  25                  30          


Cys Glu Arg Met Val Glu Ala Trp Ile Cys Ala Cys Cys Asp Cys Gln 
        35                  40                  45              


Asp Leu Phe Gly Arg Asp Lys Asn Lys Leu Leu Ile Glu Cys Asn Thr 
    50                  55                  60                  


Lys Ile Ser Met Ala Gly Asn Leu Gly Ile Pro Pro Glu Leu Met Lys 
65                  70                  75                  80  


Ser Leu Lys Thr Ile Asn Ser Met Arg Asn Asp Leu Ala His Asn Pro 
                85                  90                  95      


Ser Ile Gln Ser Ile Ala Asp Ser Arg Ile Gln Ser Leu Lys Asp Thr 
            100                 105                 110         


Leu Thr Glu Tyr Phe Lys Gln His Pro Thr Glu Pro Ser Met Glu Glu 
        115                 120                 125             


Ser Lys Leu Gly Ile Phe Asn Ala Glu Asn Gln Leu Thr Glu Glu Val 
    130                 135                 140                 


Ser Leu Asp Ser Asp Ser Ser Lys Asn Arg Leu Lys Leu Ile Leu Leu 
145                 150                 155                 160 


Phe Ser Lys Leu Met Gln Ala Leu Met Gln Leu Val Ala Ala Asn His 
                165                 170                 175     


Asn Gly Arg Trp Asp Asn Gln Phe Ser Gln Phe Val Tyr His Val Thr 
            180                 185                 190         


Met Asn Ala Thr Lys Arg 
        195             


<210> 1399
<211> 65
<212> PRT
<213> Escherichia coli

<400> 1399
Met Thr Val Val Leu Thr Ala Lys Gln Ile Glu Asp Leu Ala Ala Phe 
1               5                   10                  15      


Ala Lys Glu Asp Gly Gln Pro Gln Tyr Thr Ile Thr Thr Gly Thr Ile 
            20                  25                  30          


Pro Glu Phe Glu Ala Asp Asn Gly Glu Ile Ile Pro Gly Tyr Thr Gly 
        35                  40                  45              


Leu Ile Ala Tyr Ser Glu Ser Leu Asp His Gly Val Leu Gln Leu Asp 
    50                  55                  60                  


Asp 
65  


<210> 1400
<211> 159
<212> PRT
<213> Escherichia coli

<400> 1400
Met Val Ile Val Ala Leu Val Gly Ser Phe Leu Ala Gly Ser Glu Trp 
1               5                   10                  15      


Thr Asn Arg Ser Trp Lys Ile Lys Trp Ala Asp Arg Asp Ser Ala Glu 
            20                  25                  30          


Ser Ser Gln Glu Ala Asn Ala Gln Thr Ala Ala Arg Met Ile Glu Gln 
        35                  40                  45              


Gly Arg Thr Ile Ala Arg Asp Glu Ala Val Lys Asp Ala Gln Ala Gln 
    50                  55                  60                  


Ala Ala Ser Ala Ala Val Thr Ser Ala Gly Leu Ala Thr Thr Val Lys 
65                  70                  75                  80  


Gln Leu Arg Ala Glu Ala Thr Lys Leu Ala Thr His Met Asp Ala Ala 
                85                  90                  95      


Lys His Thr Ala Asp Leu Ala Thr Ser Val Arg Ser Lys Thr Ala Gly 
            100                 105                 110         


Ala Asn Ala Ala Met Leu Ala Asp Met Leu Gly Ser Leu Ala Glu Ala 
        115                 120                 125             


Ala Arg Tyr Tyr Ala Gly Arg Ser Asp Glu Ser Tyr Arg Ala Gly Met 
    130                 135                 140                 


Thr Cys Glu Arg Ile Tyr Glu Ser Val Arg Leu Ser Asn Asn Gln 
145                 150                 155                 


<210> 1401
<211> 182
<212> PRT
<213> Escherichia coli

<400> 1401
Met Ala Met Ser Leu Lys Leu Lys Asn Lys Leu Ser Ala Ala Val Val 
1               5                   10                  15      


Gly Leu Ile Leu Ala Gly Ala Ser Ala Pro Val Ile Leu Asp Gln Phe 
            20                  25                  30          


Leu Asp Glu Lys Glu Gly Asn Ser Leu Thr Ala Tyr Arg Asp Gly Gly 
        35                  40                  45              


Gly Leu Trp Thr Ile Cys Arg Gly Ala Thr Met Val Asp Gly Lys Pro 
    50                  55                  60                  


Val Val Gln Gly Met Lys Leu Ser Ala Glu Lys Cys Ala Gln Val Asn 
65                  70                  75                  80  


Ala Ile Glu Arg Asp Lys Ala Leu Ala Trp Val Asp Arg Asn Ile Lys 
                85                  90                  95      


Val Pro Leu Thr Glu Pro Gln Lys Ala Gly Ile Ala Ser Phe Cys Pro 
            100                 105                 110         


Tyr Asn Ile Gly Pro Gly Lys Cys Phe Pro Ser Thr Phe Tyr Lys Arg 
        115                 120                 125             


Ile Asn Ala Gly Asp Thr Lys Gly Ala Cys Glu Ala Ile Arg Trp Trp 
    130                 135                 140                 


Ile Lys Asp Gly Gly Arg Asp Cys Arg Leu Thr Lys Gly Gln Lys Asp 
145                 150                 155                 160 


Gly Cys Tyr Gly Gln Val Glu Arg Arg Asp Gln Glu Ser Ala Leu Thr 
                165                 170                 175     


Cys Trp Gly Ile Asp Gln 
            180         


<210> 1402
<211> 92
<212> PRT
<213> Escherichia coli

<400> 1402
Met Thr Arg Met Ser Thr Ile Tyr Ser Arg Leu Ser Tyr Gly Ser Gly 
1               5                   10                  15      


Thr Thr Leu Ala Gly Cys Gly Val Ser Ala Lys Ala Tyr Ala Glu Thr 
            20                  25                  30          


Ala Lys Thr Ala Lys Glu Val Ser Trp Met Leu Ala Asp Arg Ile Ala 
        35                  40                  45              


Gly Leu Ser Leu Ser Asp Trp Ala Ile Ile Val Gly Ile Ala Cys Thr 
    50                  55                  60                  


Val Ile Thr Cys Ala Val Asn Trp Tyr Phe Arg Trp Lys Glu Arg Glu 
65                  70                  75                  80  


Asp Arg Arg Asn Gly Tyr Val Ser Lys Ala Glu Glu 
                85                  90          


<210> 1403
<211> 350
<212> PRT
<213> Escherichia coli

<400> 1403
Met Lys Asn Thr Val Lys Ile Asn Ser Val Glu Leu Ile Asn Ala Asp 
1               5                   10                  15      


Ser Leu His Tyr Val Ala Thr Leu Pro Asp Asn Ser Ile Asp Leu Ile 
            20                  25                  30          


Val Thr Asp Pro Pro Tyr Phe Lys Val Lys Pro Asn Gly Trp Asp Asn 
        35                  40                  45              


Gln Trp Lys Gly Asp Glu Asp Tyr Leu Arg Trp Leu Asp Ser Cys Leu 
    50                  55                  60                  


Ala Glu Tyr Ala Arg Val Leu Lys Pro Ala Gly Ser Ile Tyr Leu Phe 
65                  70                  75                  80  


Cys Gly His Arg Leu Ala Ser Asp Ile Glu Ile Met Met Arg Ala Arg 
                85                  90                  95      


Phe Asn Val Leu Asn His Ile Ile Trp Ala Lys Pro Ser Gly Arg Trp 
            100                 105                 110         


Asn Gly Cys Asn Lys Glu Ser Leu Arg Ala Tyr Phe Pro Ser Thr Glu 
        115                 120                 125             


Arg Ile Leu Phe Ala Glu His Tyr Leu Gly Pro Tyr Thr Gly Lys Glu 
    130                 135                 140                 


Asp Val Tyr Glu Arg Lys Ser Thr Glu Leu Lys Gln His Ile Met Thr 
145                 150                 155                 160 


Pro Leu Ile Asp Tyr Phe Arg Asn Ala Arg Glu Ser Leu Gly Val Ser 
                165                 170                 175     


Ser Lys Glu Ile Ala Glu Ala Thr Gly Lys Lys Asn Met Ala Ser His 
            180                 185                 190         


Trp Phe Gly Ala Ser Gln Trp Gln Leu Pro Asn Glu Val Asp Tyr Arg 
        195                 200                 205             


Lys Leu Gln Glu Leu Phe Thr Arg Ile Ala Ile Asp Lys His Ile Gln 
    210                 215                 220                 


Gln Lys Leu Glu His Pro His His Gln Leu Val Ala Thr Tyr Gln Ser 
225                 230                 235                 240 


Leu Asn Arg Lys Tyr Ser Glu Leu Leu Glu Glu Tyr Lys Ile Leu Arg 
                245                 250                 255     


Arg Cys Phe Ser Val Ser Ala Leu Val Pro Tyr Thr Asp Val Trp Thr 
            260                 265                 270         


His Lys Pro Val Gln Phe Tyr Pro Gly Lys His Pro Cys Glu Lys Pro 
        275                 280                 285             


Ala Asp Met Leu Lys Gln Ile Ile Ser Ala Ser Ser Arg Pro Gly Asp 
    290                 295                 300                 


Ile Val Ala Asp Phe Phe Met Gly Ser Gly Ser Thr Val Lys Ala Ala 
305                 310                 315                 320 


Ile Glu Leu Gly Arg Arg Ala Ile Gly Val Glu Leu Glu Ala Asp Arg 
                325                 330                 335     


Phe Ile Gln Thr Thr Glu Glu Val Glu Lys Leu Lys Lys Ser 
            340                 345                 350 


<210> 1404
<211> 63
<212> PRT
<213> Escherichia coli

<400> 1404
Met Leu Asn Gln Glu Asp Met Thr Glu Thr Ala Lys Ala Val Phe Asn 
1               5                   10                  15      


Glu Leu Ser Asp Lys Pro Ala Thr Ala Gly Glu Ile Ala Gln Asn Thr 
            20                  25                  30          


His Leu Ser His Glu Arg Cys Gln Leu Ile Leu Thr Gln Leu Val Met 
        35                  40                  45              


Ala Gly Leu Ser Asp Tyr Gln Phe Gly Cys Tyr Lys Arg Leu Gln 
    50                  55                  60              


<210> 1405
<211> 299
<212> PRT
<213> Escherichia coli

<400> 1405
Met Pro Asn Trp Ile Asp Val Leu Gly Glu Met Gly Thr Ile Ala Gln 
1               5                   10                  15      


Arg Thr Pro Ala Asp Glu Val Arg His Lys Tyr Leu Arg Asp Leu Ser 
            20                  25                  30          


Lys His Thr Gly Arg Asn Val Ile Ser Tyr Tyr Ser Gly Phe Leu Gln 
        35                  40                  45              


Lys Gly Gly Pro Gly Phe Gln His Leu Ile Gln Met Ser Asp Asp Asp 
    50                  55                  60                  


Lys Asn Gly Leu Met Ser Ala Ile Asn Gly Leu Asp Thr Ser Leu Gly 
65                  70                  75                  80  


Leu Asp Ile Leu Leu His Thr Pro Gly Gly Asp Ile Ala Ala Leu Glu 
                85                  90                  95      


Ser Ile Gly His Tyr Leu Arg Ser Lys Phe Gly Thr Asn Ile Arg Ala 
            100                 105                 110         


Ile Val Pro Met Ile Ser Met Ser Cys Gly Thr Met Leu Ala Cys Cys 
        115                 120                 125             


Ala Glu Gln Ile Val Leu Gly Lys Gln Ser Asn Leu Gly Pro Ile Asp 
    130                 135                 140                 


Pro Gln Phe Asn Gly Leu Ser Ser His Ala Ile Ile Glu Glu Tyr Glu 
145                 150                 155                 160 


Arg Ala Lys Ala Glu Ile Phe Ala Asn Pro Ala Ala Leu Gln Trp Trp 
                165                 170                 175     


Gln Phe Thr Phe Gln Lys Leu Asn Pro Thr Leu Ile Gly Glu Cys Glu 
            180                 185                 190         


Lys Ala Ile Leu Trp Ala Asn Glu Ile Val Gln Lys Trp Leu Cys Thr 
        195                 200                 205             


Gly Met Phe Ala Gly Gln Ala Asp Ala Glu Ala Lys Ala Lys Arg Ile 
    210                 215                 220                 


Cys Asp Glu Leu Asn Asn His Gln Ala Thr Tyr Ala His Ala Arg His 
225                 230                 235                 240 


Ile His Leu Asp Lys Ala Gln Asn Ile Gly Leu Asn Ile Met Glu Leu 
                245                 250                 255     


Glu Ser Asp Gln Thr Leu Gln Asp Leu Val Leu Thr Ile His His Cys 
            260                 265                 270         


Tyr Met His Ser Phe Gly Thr Ser Pro Ala Ala Lys Ile Ile Glu Asn 
        275                 280                 285             


His Asn Gly Ser Thr Met Met Trp Asn Ile Cys 
    290                 295                 


<210> 1406
<211> 68
<212> PRT
<213> Escherichia coli

<400> 1406
Met Ser Ala Ala Glu Phe Tyr Glu Lys Met Gly Ile Gln Pro Gln Glu 
1               5                   10                  15      


Phe Gln Lys Gly Glu Ser Val Gln His Phe Ala Met Arg Val Leu Ala 
            20                  25                  30          


Gln Gln Asn Asp Leu Asn Val Arg Ser Gly Val Leu Tyr Ser Tyr Ser 
        35                  40                  45              


Thr Val Thr Pro Asn Thr Thr Glu Gln Asn Gly Gln Gln Ser His Gln 
    50                  55                  60                  


Leu Tyr Ser Tyr 
65              


<210> 1407
<211> 229
<212> PRT
<213> Escherichia coli

<400> 1407
Met Asn Gln Gln Asp Leu Asn Phe Val Arg Ile Glu Leu Arg Arg Ala 
1               5                   10                  15      


Leu Pro Asp Leu Ser Gly Gly Thr Lys Gly Gln Leu Glu Ala Phe Ser 
            20                  25                  30          


Glu His Pro Pro Ala Asp Lys Asn Ala Thr Pro Arg Arg Gly Ile His 
        35                  40                  45              


Leu Val Glu Leu Glu Gly Glu Lys Gly Pro Arg Phe Val Asn Ser Leu 
    50                  55                  60                  


Ser Ala Pro Leu Tyr Val Leu Glu Thr Arg Ser Arg Arg Arg Pro Met 
65                  70                  75                  80  


Pro Pro Ile Lys Asp Ala Glu Phe Glu Ser Ala Pro Trp Arg Arg Ala 
                85                  90                  95      


Val Ser Ala Leu Ser Gly Tyr Gln Gln Ala Trp Leu Arg Tyr Cys Tyr 
            100                 105                 110         


Gly Phe Asp Leu Ser Tyr Lys His Gln Val Met Met Cys Glu Tyr Val 
        115                 120                 125             


Trp Lys Thr Tyr Gln Lys Cys Leu Gly Asp Asn Ser Leu Gln Glu Arg 
    130                 135                 140                 


Val Val Lys Lys Leu Ile Gly Leu Val Trp Leu Ala Gly Gln Glu Ile 
145                 150                 155                 160 


Ala Ala Thr Arg Asn Asn Glu Thr Tyr Lys Asp Tyr Ala Gly Ala Ala 
                165                 170                 175     


Leu Ala Arg Met Val Ser Val Asp Arg Ser Thr Trp Leu Arg Val Tyr 
            180                 185                 190         


Ser Gly His Trp Ala Gly Leu Lys Ala Ala Phe Thr Gln Leu Asp Glu 
        195                 200                 205             


Ser Ala Leu Ala Met Ala Leu Glu Tyr Tyr Glu Glu Glu Glu Ala Leu 
    210                 215                 220                 


Lys Val Ala Glu Met 
225                 


<210> 1408
<211> 331
<212> PRT
<213> Escherichia coli

<400> 1408
Met Arg Ala Leu Leu Thr Pro Glu Ile Ala His Arg Met Gly Ile Val 
1               5                   10                  15      


Leu Phe Arg Pro Gly Ala Glu Leu Met His Leu Phe Met Arg Gly Arg 
            20                  25                  30          


Val Leu Leu Glu Pro Glu Pro Glu Glu Met Ala Ser Phe Ser Thr Gly 
        35                  40                  45              


Ala Val Pro Ala Ala Ile Gln Pro Leu Ala Asp Asp Pro Val Met Arg 
    50                  55                  60                  


Gln Val Phe Glu Asn Asp Arg Val Ile Gln Arg Ala Gly Gly Leu Pro 
65                  70                  75                  80  


Ser Leu Glu Gln Trp Leu Ser Asn Arg Phe Glu Cys Gln Trp Pro His 
                85                  90                  95      


Ser Ser Trp His Asp Lys Asn Phe Thr Thr Met Arg His Pro Pro Gly 
            100                 105                 110         


Ser Ile Arg Leu Cys Trp His Cys Asp His Thr Leu Ser Gly Gln His 
        115                 120                 125             


Thr Glu Gln Leu Ala Gly Ile Ala Ala Gly Asn Leu Val Ser Trp Ile 
    130                 135                 140                 


Leu Glu Val Ile Arg Arg Asp Ser Gly Phe Pro Glu Ser His Ile Leu 
145                 150                 155                 160 


Thr Leu Pro Glu Leu Cys Trp Trp Met Val Arg Asn Asp Leu Ala Asp 
                165                 170                 175     


Val Ile Pro Glu Ser Val Ala His Lys Gly Leu Arg Leu Pro Asp Asp 
            180                 185                 190         


Lys Ile Arg Ser Val Met Arg Glu Ser Asp Ile Val Pro Ser Ala Ser 
        195                 200                 205             


Ala Thr Ser Leu Val Gln Glu Lys Ala Lys Lys Ile Leu Thr Leu Ser 
    210                 215                 220                 


Val Asp Pro Glu Ser Pro Glu Ser Phe Met Leu Arg Pro Lys Arg Arg 
225                 230                 235                 240 


Arg Trp Ile Asn Glu Thr Tyr Thr Arg Trp Val Lys Thr Gln Pro Cys 
                245                 250                 255     


Glu Cys Cys Arg Arg Pro Ala Asp Asp Pro His His Ile Val Gly His 
            260                 265                 270         


Gly Met Gly Gly Thr Ala Thr Lys Ala His Asp Leu Phe Val Ile Pro 
        275                 280                 285             


Leu Cys Arg Glu Cys His Asp Glu Leu His Ala Asp Val Pro Ala Phe 
    290                 295                 300                 


Glu Gln Lys His Gly Thr Gln Leu Glu Leu Leu Leu Arg Phe Met Asp 
305                 310                 315                 320 


Arg Ala Leu Ala Ile Gly Val Ile Ala Lys Ala 
                325                 330     


<210> 1409
<211> 227
<212> PRT
<213> Escherichia coli

<400> 1409
Met Ser Gln Leu Ala Thr Thr Ala Leu Thr Met Ser Ser Ser Asp Ile 
1               5                   10                  15      


Ala Glu Leu Val Glu Ser Arg His Asp His Val Lys Arg Ser Ile Glu 
            20                  25                  30          


Arg Leu Ala Glu Arg Gly Val Ile Glu Leu Pro Pro Met Gly Glu Val 
        35                  40                  45              


Lys Asn His Leu Asn Gln Ser Val Ser Val Tyr Leu Ile Gly Lys Arg 
    50                  55                  60                  


Asp Ser Tyr Ile Val Val Ala Gln Leu Ser Pro Glu Phe Thr Ala Arg 
65                  70                  75                  80  


Leu Val Asp Arg Trp Gln Glu Leu Glu Gln Ala Gln Gln Gln Thr Ile 
                85                  90                  95      


Pro Gln Ser Phe Ser Glu Ala Leu Arg Leu Ala Ala Asp Leu Ala Glu 
            100                 105                 110         


Gln Lys Gln Gln Leu Thr Asn Glu Leu Ala Ala Ala Ala Pro Lys Val 
        115                 120                 125             


Ala Phe Val Asp Arg Tyr Cys Thr Ala Ser Gly Ser Met Ser Phe Arg 
    130                 135                 140                 


Gln Val Ala Lys Leu Leu Lys Ala Lys Glu Pro Asp Leu Arg Leu Phe 
145                 150                 155                 160 


Leu Leu Glu Asn Asp Ile Met Tyr Arg Leu Gly Gly Thr Met Thr Pro 
                165                 170                 175     


Arg His Gln His Ile Asp Ala Gly Arg Phe Glu Val Lys Thr Gly Thr 
            180                 185                 190         


Ser Val Thr Ser Asn His Ala Phe Ser Gln Ala Arg Phe Thr Ala Lys 
        195                 200                 205             


Gly Val Arg Trp Ile Gly Gly Leu Trp Ala Glu His Ile Ala Arg Gly 
    210                 215                 220                 


Gln Val Ala 
225         


<210> 1410
<211> 128
<212> PRT
<213> Escherichia coli

<400> 1410
Met Lys Leu Ile Leu Pro Phe Pro Pro Ser Val Asn Thr Tyr Trp Arg 
1               5                   10                  15      


Ala Pro Asn Lys Gly Pro Leu Ala Gly Arg His Leu Ile Ser Ala Ala 
            20                  25                  30          


Gly Arg Lys Tyr Gln Ser Ala Ala Cys Val Ala Ile Ile Glu Gln Leu 
        35                  40                  45              


Arg Arg Leu Pro Lys Pro Ser Thr Glu Leu Ala Ala Val Glu Ile Thr 
    50                  55                  60                  


Leu Tyr Pro Pro Asp Ala Arg Arg Arg Asp Ile Asp Asn Tyr Asn Lys 
65                  70                  75                  80  


Ala Leu Phe Asp Ala Leu Thr His Ala Gly Val Trp Glu Asp Asp Ser 
                85                  90                  95      


Gln Ile Lys Arg Met Leu Val Glu Trp Gly Pro Val Val Pro Lys Gly 
            100                 105                 110         


Arg Val Glu Ile Thr Ile Ser Arg Tyr Glu Pro Ala Gly Ala Ala Ala 
        115                 120                 125             


<210> 1411
<211> 439
<212> PRT
<213> Escherichia coli

<400> 1411
Met Met Thr Asn Lys Tyr Cys Gln Ala Leu Ala Ala Leu Arg Ser Lys 
1               5                   10                  15      


Pro Ala His Glu Leu Lys Glu Val Gly Asp Gln Trp Arg Thr Pro Asp 
            20                  25                  30          


Leu Leu Phe Trp Gly Ile Asn Ala Leu Phe Gly Pro Leu Val Leu Asp 
        35                  40                  45              


Leu Phe Ala Asp Asp Asp Asn Ala Lys Cys Pro Ala Trp Tyr Thr Ala 
    50                  55                  60                  


Glu Asp Asn Ala Leu Thr Gln Asp Trp Ser Glu Arg Leu Ala Glu Leu 
65                  70                  75                  80  


Gly Gly Ala Gly Tyr Gly Asn Pro Pro Tyr Ser Arg Ser Gln Tyr His 
                85                  90                  95      


Glu Lys Gln Ala Ile Thr Gly Met Thr His Ile Met Asn Tyr Ala Ala 
            100                 105                 110         


Ala Gln Arg Glu Lys Gly Gly Arg Tyr Val Phe Leu Ile Lys Ala Ala 
        115                 120                 125             


Pro Ser Glu Thr Trp Trp Pro Glu Asp Ala Asp His Ile Val Phe Ile 
    130                 135                 140                 


Arg Gly Arg Ile Gly Phe Asp Leu Pro Val Trp Phe Val Pro Ala Asp 
145                 150                 155                 160 


Glu Lys Gln Lys Pro Thr Ser Ala Phe Phe Ala Gly Ala Ile Ala Val 
                165                 170                 175     


Phe Asp Lys Ser Trp Arg Gly Glu Arg Phe Ser Tyr Ile Asn Arg Thr 
            180                 185                 190         


Glu Leu Glu Ala Lys Gly Arg Ala Phe Met Ala Leu Ala Gln Phe Ala 
        195                 200                 205             


Ala Ser Lys Ser Gln Pro Val Thr Ala Thr Pro Pro Ala Ala Asp Lys 
    210                 215                 220                 


Pro Glu Ala Glu Leu Pro Leu Thr Gln Lys Asp Ile Phe Ala Ile Ser 
225                 230                 235                 240 


Gly Val Glu Ala Trp Ala Cys Val Arg Ala Ala Phe Gly Asp Lys Glu 
                245                 250                 255     


Glu Tyr Thr Phe Ser Glu Ser Lys Phe Gly His Thr Trp Ala Ala Asp 
            260                 265                 270         


Ser Val Glu Ala Pro Glu Phe Thr Gln Val Ser Pro Leu Thr Ile Asp 
        275                 280                 285             


Lys Ala Lys Leu Leu Ile Arg Glu Ser Ile Leu Phe Gly Val Asp Glu 
    290                 295                 300                 


Trp Leu Leu Ser Ile Glu Phe Asp Asp Ala Ala Val Arg Leu Asp Met 
305                 310                 315                 320 


Ser Glu Arg Ile Arg Thr Val Ala Leu Glu Ala Ser Gly Glu Tyr Gly 
                325                 330                 335     


Met Asn Ser Thr Asp Phe Ile Ala Ala Met Gly Ser Leu Asp Val Ser 
            340                 345                 350         


Ser Trp Ser Asn Ile Arg Gln Ile Arg Met His Ile Arg Glu Lys Ala 
        355                 360                 365             


Lys Pro Val Ser Asp Pro Leu Pro Glu Ser Arg Ile Trp Pro Leu Glu 
    370                 375                 380                 


Val Arg Ile Val Phe Asp Gln Val Asp Gly Ala Asp Met Leu Asp Glu 
385                 390                 395                 400 


Ser Leu Gln His Lys Leu Lys Ala Asn Ile Asn Gln Leu Trp Leu Glu 
                405                 410                 415     


Arg Thr Ala Thr Ser Glu Ile Ile Thr Ala Ala Ser Glu Leu Val Arg 
            420                 425                 430         


Asn Met Arg Gly Glu Ala Ala 
        435                 


<210> 1412
<211> 293
<212> PRT
<213> Escherichia coli

<400> 1412
Met Ser Thr Lys Leu Thr Gly Tyr Val Trp Asp Ala Cys Ala Ser Ser 
1               5                   10                  15      


Gly Met Lys Leu Ser Ser Val Ala Ile Met Ala Arg Leu Ala Asp Phe 
            20                  25                  30          


Ser Ser Asp Glu Gly Val Ser Trp Pro Ser Ile Gly Thr Ile Ala Arg 
        35                  40                  45              


Gln Ile Gly Ala Gly Glu Ser Thr Val Arg Thr Ala Leu Ala Gln Leu 
    50                  55                  60                  


Glu Lys Asp Gly Trp Leu Ser Arg Lys Gln Arg Arg Asn Gly Asn Arg 
65                  70                  75                  80  


Asn Ala Ser Asn Val Tyr Gln Leu Asn Val Val Lys Leu Arg Glu Ala 
                85                  90                  95      


Ala Phe Ser His Leu Ser Glu Ser Asp Ala Ser Lys Ser Asp Pro Ser 
            100                 105                 110         


Lys Ser Asp Ala Ser Lys Ser Asp Pro Ser Lys Phe Glu Ala Ser Lys 
        115                 120                 125             


Ser Ser Lys Lys Gly Gly Phe Asp Pro Ser Glu Ser Gly Gly Asp Pro 
    130                 135                 140                 


Ser Val Lys Ser Lys Gln Glu Pro Gln Val Thr Ser Lys Pro Ser Cys 
145                 150                 155                 160 


Pro Val Ala Ala Gln Pro Asp Pro Glu Val Val Ile Thr Asp Gln Ala 
                165                 170                 175     


Arg Gln Val Leu Ser Tyr Leu Asn Gln Thr Thr Gly Ser Arg Tyr Gln 
            180                 185                 190         


Val Cys Ser Thr Ser Leu Glu Asn Ile Arg Ala Arg Leu Arg Glu Gln 
        195                 200                 205             


Phe Thr Val Asp Asp Leu Cys Leu Val Val Asp Tyr Lys Asn Ala Asp 
    210                 215                 220                 


Trp Arg Asp Ser Glu Gln Ala Gln Tyr Leu Arg Pro Ala Thr Leu Phe 
225                 230                 235                 240 


Ile Pro Lys Asn Phe Pro Gly Tyr Leu Gln Ser Ala Thr Lys Trp Ser 
                245                 250                 255     


Ser Ala Gly Arg Pro Glu Arg Val Asn Gly Lys Trp Glu Thr Asn Ser 
            260                 265                 270         


Ala Ser Arg Ala Asn Phe Gln Ser Val Asp Tyr Ser Leu Pro Glu Asn 
        275                 280                 285             


Ser Gly Phe Arg Ser 
    290             


<210> 1413
<211> 112
<212> PRT
<213> Escherichia coli

<400> 1413
Met Asn Ser Val Asn Arg Phe Arg Pro Ala Lys Gln Phe Arg Cys Leu 
1               5                   10                  15      


Pro Leu Val Gly Lys Asp Ala Gln Phe Gly Tyr Val Glu Ile Ile Asn 
            20                  25                  30          


Asn Ala Ala Asp Gly Gly Asn Tyr Gln Pro Ala Asp Leu Met Val Glu 
        35                  40                  45              


Ala Phe Val Gln Met Asn Glu Lys Gly Arg Glu Glu Trp Leu Lys Leu 
    50                  55                  60                  


Thr Gly Gly Ser Glu Ile Thr Thr Glu Phe Pro Ser Glu Leu Ser Ala 
65                  70                  75                  80  


Gly Ser Gln Ile His Ser Ala Leu Tyr Thr Phe Ala Lys Gly Thr Ile 
                85                  90                  95      


Met Ser Ala Ser Ala Leu Leu Asn Asn Ser Ser Val Asn Leu Gln Asn 
            100                 105                 110         


<210> 1414
<211> 187
<212> PRT
<213> Escherichia coli

<400> 1414
Met Val Asp Ser Ile Asn Thr Ala Ile Arg Leu Met Cys Lys Ala His 
1               5                   10                  15      


Lys His Gly Arg Leu Gly Met Ala Ser Asp Leu Gly Met Thr Ile Asp 
            20                  25                  30          


Gln Phe His Asn His Leu Tyr Gln Lys Cys Gly Ser Arg Phe Phe Thr 
        35                  40                  45              


Leu Ala Glu Leu Glu Arg Met Glu Asp Leu Ser Gly Ser Cys Tyr Leu 
    50                  55                  60                  


Ala Glu Tyr Gln Ala Asn Arg Lys Gly Lys Trp Leu Val Asp Val Pro 
65                  70                  75                  80  


Thr Ala Glu Ser Leu Asp Asn Val Glu Leu Tyr Ser Ile Glu Met Lys 
                85                  90                  95      


Ala Ala Ala Ala Ser Gly Glu Leu Ala Asn Ala Lys Met Ala Ala Ala 
            100                 105                 110         


Ala Asp Gly Val Ile Asp Ser Ser Glu Arg Lys Met Leu Ser Glu Leu 
        115                 120                 125             


Phe Ser Lys Lys Leu Arg His Gln Ile His Gly Phe Leu Gly Phe Met 
    130                 135                 140                 


Ala Leu Tyr Gly Val Gly Val Ser Asp Gln Ala Ile Asp Val Phe Val 
145                 150                 155                 160 


Ser Thr Gly Arg Lys Gly Asp Ala Arg Glu Cys Ala Ala Pro Gly Ala 
                165                 170                 175     


Leu Ala Cys Arg Ile Ser Gly Glu Thr Asn Ala 
            180                 185         


<210> 1415
<211> 85
<212> PRT
<213> Escherichia coli

<400> 1415
Met Ser Ser Gln His Lys Asn Val Thr Ala Lys Ala Val Lys Ala Ile 
1               5                   10                  15      


Gly Ser Ile Ser Glu Val Ser Arg Arg Phe Glu Phe Gln Ser Val Gln 
            20                  25                  30          


Ser Val Ala Asn Trp Ile Ala Lys Asn Arg Val Pro Ser Glu Arg Val 
        35                  40                  45              


Ile Gln Leu Cys Gln Trp Gly Gly Trp Val Val Thr Pro His Gln Leu 
    50                  55                  60                  


Arg Pro Asp Ile Tyr Pro Asn Lys Asn Asp Gly Ile Pro Ser Ala Asn 
65                  70                  75                  80  


Asn Asn Ser Gln Leu 
                85  


<210> 1416
<211> 236
<212> PRT
<213> Escherichia coli

<400> 1416
Met Pro Cys Ala Leu Asn Leu Leu Leu Met Val Glu Asn Ala Lys Tyr 
1               5                   10                  15      


Lys Asp Phe Ala Glu Arg Leu Asn Arg Ser Leu Gln Glu Gln Ser Ile 
            20                  25                  30          


Gly Val Lys Glu Leu Ser Glu Phe Ser Gly Val Ser Tyr Glu Met Ala 
        35                  40                  45              


Arg Arg Tyr Thr Leu Gly Thr Ala Lys Pro Arg Asp Glu Lys Met Ile 
    50                  55                  60                  


Arg Ile Ala Glu Arg Leu Ala Val Ser Pro Ala Tyr Leu Asp Tyr Gly 
65                  70                  75                  80  


Val Pro Val Asn Gly Gly Asp Ala Pro Ala Lys Gly Thr Val Arg Ile 
                85                  90                  95      


Glu Gln Leu Asp Val His Ala Ser Ala Gly Ser Gly Tyr Ile Asn Gln 
            100                 105                 110         


Pro Phe Pro Thr Ile Val Ser Ser Ile Glu Ile Pro Glu Glu Arg Ile 
        115                 120                 125             


Phe Glu Leu Phe Gly Arg Arg Ser Leu Asp Gly Ile Val Met Ile Asn 
    130                 135                 140                 


Val Asp Gly Asp Ser Met Met Pro Thr Leu Cys Pro Lys Asp Leu Leu 
145                 150                 155                 160 


Phe Ile Asp Ser Lys Val Glu Gln Phe Ser Gly Asp Gly Val Tyr Val 
                165                 170                 175     


Phe Asn Phe Glu Asp Ser Thr Phe Val Lys Arg Leu Gln Lys Val Lys 
            180                 185                 190         


Gly Arg Arg Leu Ala Val Leu Ser Asp Asn Glu His Tyr Pro Pro Phe 
        195                 200                 205             


Phe Ile Glu Glu His Glu Met Asn Glu Leu Tyr Ile Phe Gly Lys Leu 
    210                 215                 220                 


Ile Arg Cys Leu Pro Leu Lys Met Ile Glu Phe Gly 
225                 230                 235     


<210> 1417
<211> 65
<212> PRT
<213> Escherichia coli

<400> 1417
Met Gly Ala Phe Asp Asn Gln Glu Ile Thr Leu Pro Ala Cys Pro Lys 
1               5                   10                  15      


Cys Gly Thr Lys Thr Lys Lys Lys Ile Ala Trp Leu Lys Ser Asn Lys 
            20                  25                  30          


Ser Phe Thr Cys Arg Cys Gly Ala Thr Ile Asn Val Asn Ser Ser Gln 
        35                  40                  45              


Leu Thr Ser Glu Ile Arg Lys Val Glu Asp Lys Leu Lys Lys Leu Phe 
    50                  55                  60                  


Lys 
65  


<210> 1418
<211> 305
<212> PRT
<213> Escherichia coli

<400> 1418
Met Asn Asn Pro Phe Phe Lys Asn Met Leu Val Tyr Arg Ile Ser Arg 
1               5                   10                  15      


Asp Phe Thr Ile Asn Gln Glu Glu Leu Glu Gln Gln Leu Glu Leu Phe 
            20                  25                  30          


Arg Phe Thr Pro Cys Gly Ser Gln Asp Met Ala Lys Thr Gly Trp Val 
        35                  40                  45              


Ser Pro Leu Gly Gln Leu Ser Asp Arg Leu His His Thr Val Asn Asn 
    50                  55                  60                  


Gln Val Leu Leu Val Ile Arg Arg Glu Glu Lys Ile Leu Pro Ser Pro 
65                  70                  75                  80  


Val Ile Thr Glu Glu Leu Arg Lys Arg Val Ser Arg Leu Glu Ser Asp 
                85                  90                  95      


Gln Gly Arg Arg Leu Lys Lys Thr Glu Lys Asp Ser Leu Arg Asp Glu 
            100                 105                 110         


Val Leu His Ser Leu Leu Pro Arg Ala Phe Ser Lys Asn Ser Thr Val 
        115                 120                 125             


Gly Leu Trp Ile Asn Val Thr Asp Gly Leu Ile Met Val Asp Ala Ala 
    130                 135                 140                 


Ser Ala Lys Arg Ala Glu Asp Ser Leu Ala Leu Leu Arg Lys Thr Leu 
145                 150                 155                 160 


Gly Ser Leu Pro Val Val Pro Leu Thr Met Glu Thr Pro Ile Glu Leu 
                165                 170                 175     


Thr Met Thr Asp Trp Val Arg Ser Gly Ser Ala Pro Ala Gly Phe Gly 
            180                 185                 190         


Leu Gly Asp Glu Ala Glu Leu Lys Ala Ile Leu Glu Asp Gly Gly Ile 
        195                 200                 205             


Gly Arg Phe Lys Lys Gln Thr Leu Val Ser Asp Glu Ile His Val His 
    210                 215                 220                 


Leu Glu Ala Gly Lys Val Val Thr Lys Leu Ser Ile Asp Trp Gln Gln 
225                 230                 235                 240 


Arg Ile Gln Phe Val Leu Cys Asp Asp Gly Ser Ile Lys Arg Leu Lys 
                245                 250                 255     


Phe Ser Asn Glu Ile Thr Glu Gln Asn Asp Asp Ile Asp Arg Glu Asp 
            260                 265                 270         


Ala Ala Gln Arg Phe Asp Ala Asp Phe Val Leu Met Thr Gly Glu Leu 
        275                 280                 285             


Ile Ser Leu Ile Asn Gly Leu Thr Thr Ser Leu Gly Gly Glu Ala Lys 
    290                 295                 300                 


Arg 
305 


<210> 1419
<211> 179
<212> PRT
<213> Escherichia coli

<400> 1419
Met Ser Tyr Ile Gln Thr Leu Ser Gly Lys His Phe Asn Tyr Leu Asp 
1               5                   10                  15      


Ile Gln Gln Asp Asp Ile Val Ile Glu Asp Ile Ala Thr Ala Leu Ser 
            20                  25                  30          


His Ile Cys Arg Phe Ala Gly His Leu Pro Glu Phe Tyr Ser Val Gly 
        35                  40                  45              


Gln His Ser Val Leu Thr Ser His Leu Val Pro Gln Glu Phe Ala Leu 
    50                  55                  60                  


Glu Ala Leu Leu His Asp Ala Ala Glu Ala Tyr Leu Gln Asp Ile Pro 
65                  70                  75                  80  


Ser Pro Leu Lys Arg Leu Leu Pro Asp Tyr Gln Ala Ile Glu Ala Arg 
                85                  90                  95      


Val Asp Ala Ala Ile Arg Gln Lys Phe Gly Leu Pro Thr Glu Gln His 
            100                 105                 110         


Pro Thr Val Lys Tyr Ala Asp Leu Val Met Leu Ala Ser Glu Arg Arg 
        115                 120                 125             


Asp Phe Glu Ile Asp Glu Gly Ser Ile Trp Pro Cys Leu Glu Gly Val 
    130                 135                 140                 


Val Pro Thr Asp Leu Phe Ile Ile Asn Pro Val Arg Pro Gly Gln Ser 
145                 150                 155                 160 


Tyr Gly Met Phe Ile Asn Arg Phe Asn Glu Leu Met Glu Gln Arg Gln 
                165                 170                 175     


Cys Ala Ala 
            


<210> 1420
<211> 84
<212> PRT
<213> Escherichia coli

<400> 1420
Met Thr Val Phe Glu Tyr Leu Gln Ala His Pro Asn Thr Thr Ser Gly 
1               5                   10                  15      


Glu Ile Ala Lys Gly Met Asn Lys Lys Thr Pro Ala Val Ala Gly Ala 
            20                  25                  30          


Leu Ser Gln Leu Tyr Gly Thr Gly Arg Ile Val Lys Ser Gly Val Arg 
        35                  40                  45              


Lys Gly Ile Pro Thr Tyr Arg Ile Asn Asp Met Pro Phe Gly Cys Ser 
    50                  55                  60                  


Asn Ser Leu Thr Met Met Phe Asn Gln Leu Leu Ser Arg Ala Arg Gln 
65                  70                  75                  80  


Gly Ala Ala Gln 
                


<210> 1421
<211> 115
<212> PRT
<213> Escherichia coli

<400> 1421
Met Thr Ala Leu Asn Lys Gln Ala Leu Arg Glu Glu Phe Gln Phe Met 
1               5                   10                  15      


Gln Asp Asn Tyr Ser Asp Pro Ala Asp His Asp Arg Gln Val Ile Tyr 
            20                  25                  30          


Ile Glu Ala Glu Ala Leu Leu Asp Glu Leu Glu Ala Lys Asp Ser Thr 
        35                  40                  45              


Ile Ala Ala Gln Gln His Glu Ile Arg Met Leu Leu Asn Ala Leu Glu 
    50                  55                  60                  


Glu Lys Pro Cys Pro Lys Cys Asn Asp Thr Gly Met Thr Asp Ser Gly 
65                  70                  75                  80  


Gly Thr Gln Pro Trp Gly Glu Pro Ile Glu Ile Glu Cys Asp Cys Arg 
                85                  90                  95      


Gln Gln Asp Ala Asn Thr Ala Glu Leu Val Ala Ala Gly Ile Gly Val 
            100                 105                 110         


Lys Gly Glu 
        115 


<210> 1422
<211> 102
<212> PRT
<213> Escherichia coli

<400> 1422
Met Asp Lys Leu Ile Lys Pro Thr Ala Lys Gly Lys Tyr Asp Gly Ser 
1               5                   10                  15      


Cys Asp Tyr Leu Cys Ser Glu Asp Ala Arg Phe Ile Val Met Arg Gly 
            20                  25                  30          


Asp Tyr Thr Glu Ala Glu Ile Ile Gln Ala Ser Val Ser Gln Asp Val 
        35                  40                  45              


Ile Asp Ser Asp Gly Ala Ala Asp Phe Ala Ser Ser Ala Arg Tyr Tyr 
    50                  55                  60                  


Gln Cys Trp Tyr Lys Val Ser Pro Ile Gly Gly Gln Asp Gly Tyr Ser 
65                  70                  75                  80  


Gly Trp His His Pro Arg Asp Ser Pro Cys Arg Gly Ala Tyr Phe Ala 
                85                  90                  95      


Ser Val Leu Gln Trp Asp 
            100         


<210> 1423
<211> 155
<212> PRT
<213> Escherichia coli

<400> 1423
Met Thr Thr Asn Asn His Pro Ala His Gly Pro Val Ser Leu Asp Arg 
1               5                   10                  15      


Leu His Gln Ile Arg Glu His Leu Leu His Asp Thr Gln Tyr Ser Asn 
            20                  25                  30          


Gly Gly Asn Arg Ala Tyr Ile Leu Ala Asp Val Leu Lys Val Ile Asp 
        35                  40                  45              


Gly Ala Ile Ala Arg Glu Leu Val Arg Arg Glu His Ala Ala Trp Ser 
    50                  55                  60                  


Gln Ala Thr Phe Gly Asp Val Gly Pro Val Gly Pro Leu Lys His Leu 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Glu Ala Ala Ala Glu Pro Gly Asp Leu Ser Glu 
                85                  90                  95      


Trp Ala Asp Met Gln Phe Leu Leu Trp Asp Ala Gln Arg Arg Ala Gly 
            100                 105                 110         


Ile Ser Asp Glu Gln Ile Thr Gln Ala Met Ile Lys Lys Leu Ala Ile 
        115                 120                 125             


Asn Lys Val Arg Gln Trp Pro Glu Pro Lys Asp Gly Glu Pro Arg Leu 
    130                 135                 140                 


His Ile Lys Glu Gln Ser Glu Gln Glu Lys Lys 
145                 150                 155 


<210> 1424
<211> 84
<212> PRT
<213> Escherichia coli

<400> 1424
Met Phe Ser Leu Ile Arg Arg Gly Gln Ile Tyr Thr Asp Ser Ser Asn 
1               5                   10                  15      


Trp Pro Val Ile Ile His Ser Cys Ser Asp His Ser Val Arg Ile Lys 
            20                  25                  30          


Arg Asn Asp Gly Glu Leu Arg Thr Ile Ser Ile Lys Arg Phe Asn Glu 
        35                  40                  45              


Asp Phe Glu Arg Val Glu His Asp Glu Tyr Arg Lys Ile Cys Ala Glu 
    50                  55                  60                  


Ile Glu Gln Glu Thr Asn Leu Lys Asn Leu Arg Ala Met Arg Arg Gly 
65                  70                  75                  80  


Lys Ile Thr Glu 
                


<210> 1425
<211> 189
<212> PRT
<213> Escherichia coli

<400> 1425
Met Asn Asn Leu Met Ile Asp Leu Glu Ser Met Gly Lys Lys Pro Asn 
1               5                   10                  15      


Ala Pro Ile Val Ser Ile Gly Ala Val Phe Phe Asp Pro Gln Ser Gly 
            20                  25                  30          


Glu Leu Gly Gln Glu Phe Tyr Thr Ala Val Asn Leu Glu Ser Ala Met 
        35                  40                  45              


Glu Gln Gly Ala Val Pro Asp Gly Asp Thr Ile Leu Trp Trp Leu Arg 
    50                  55                  60                  


Gln Ser Ser Glu Ala Arg Ser Ala Ile Cys Val Asp Asp Ala Met Pro 
65                  70                  75                  80  


Ile Ser Ser Ala Leu Ser Glu Leu Ser His Phe Ile Asn Arg His Ser 
                85                  90                  95      


Asp Asn Pro Lys Tyr Leu Lys Val Trp Gly Asn Gly Ala Thr Phe Asp 
            100                 105                 110         


Asn Val Ile Leu Arg Gly Ala Tyr Glu Arg Ala Gly Gln Val Cys Pro 
        115                 120                 125             


Trp Gln Phe Trp Asn Asp His Asp Val Arg Thr Ile Val Thr Leu Gly 
    130                 135                 140                 


Arg Ser Val Gly Phe Asp Pro Lys Arg Asp Met Pro Phe Asp Gly Val 
145                 150                 155                 160 


Ala His Asn Ala Leu Ala Asp Ala Arg His Gln Ala Lys Tyr Val Ser 
                165                 170                 175     


Ala Ile Trp Gln Lys Leu Ile Pro Thr Thr Ser Asn Ser 
            180                 185                 


<210> 1426
<211> 78
<212> PRT
<213> Escherichia coli

<400> 1426
Met Ser Asn Ile Phe Gln Leu Ala Pro Asn Asp Trp Val Cys Glu Ser 
1               5                   10                  15      


Val Leu Ile Ala Val Thr Gly Leu Lys Pro Gly Thr Ile Leu Arg Ala 
            20                  25                  30          


Arg Lys Glu Cys Trp Met Ile Gly Arg Glu Tyr Ile His Val Ser Pro 
        35                  40                  45              


Asp Gly Asn Pro Lys Pro Ser Ser Glu Cys Met Tyr Asn Arg Lys Ala 
    50                  55                  60                  


Val Asp Ala Trp Val Ala Ser Met Lys Ser Lys Gln Pro Gly 
65                  70                  75              


<210> 1427
<211> 437
<212> PRT
<213> Escherichia coli

<400> 1427
Met Asp Lys Val Thr Tyr Pro Thr Gly Val Glu Asn His Gly Gly Thr 
1               5                   10                  15      


Leu Arg Ile Trp Phe Asn Phe Lys Gly Lys Arg Val Arg Glu Ser Leu 
            20                  25                  30          


Gly Val Pro Asp Thr Ala Lys Asn Arg Lys Ile Ala Gly Glu Leu Arg 
        35                  40                  45              


Thr Ser Val Cys Phe Ala Ile Arg Thr Gly Thr Phe Asp Tyr Ala Thr 
    50                  55                  60                  


Gln Phe Pro Asp Ser Pro Asn Leu Lys Ala Phe Gly Val Ser Lys Lys 
65                  70                  75                  80  


Asp Ile Thr Val Lys Glu Leu Glu Glu Lys Trp Leu Asp Leu Lys Arg 
                85                  90                  95      


Met Glu Ile Cys Ala Asn Ala Phe Asn Arg Tyr Glu Ser Val Ala Arg 
            100                 105                 110         


Asn Met Val Pro Arg Ile Gly Gly Asn Arg Leu Val Ser Ala Val Thr 
        115                 120                 125             


Lys Glu Glu Leu Leu Tyr Leu Arg Lys Tyr Leu Leu Thr Gly Tyr Gln 
    130                 135                 140                 


Asn Pro Thr Lys Asn Lys Ala Pro Ala Lys Gly Arg Ser Val Val Thr 
145                 150                 155                 160 


Val Asn Tyr Tyr Met Thr Thr Met Ala Gly Met Phe Gln Phe Ala Ala 
                165                 170                 175     


Asp His Gly Tyr Leu Glu Val Asn Pro Phe Glu Gly Ile Lys Pro Leu 
            180                 185                 190         


Lys Lys Ala Arg Ala Glu Pro Asp Pro Leu Ser Arg Asp Glu Phe Ile 
        195                 200                 205             


Arg Leu Ile Asp Ala Cys Arg His Gln Gln Thr Lys Asn Leu Trp Ser 
    210                 215                 220                 


Leu Ala Val Tyr Thr Gly Met Arg His Gly Glu Leu Val Ser Leu Ala 
225                 230                 235                 240 


Trp Glu Asp Ile Asp Leu Lys Ala Gly Thr Ile Thr Val Arg Arg Asn 
                245                 250                 255     


Tyr Thr Lys Leu Gly Glu Phe Thr Leu Pro Lys Thr Glu Ala Ser Thr 
            260                 265                 270         


Asp Arg Val Val His Leu Ile Gln Pro Ala Ile Ser Ile Leu Lys Asn 
        275                 280                 285             


Gln Ala Glu Met Thr Arg Leu Gly Arg Gln Tyr His Ile Glu Val Gln 
    290                 295                 300                 


Leu Arg Glu Tyr Gly Arg Ser Val Asn His Glu Cys Thr Phe Val Phe 
305                 310                 315                 320 


Asn Pro His Val Val Arg Arg Ser Lys Gln Val Gly Phe Ile Tyr Arg 
                325                 330                 335     


Val Asp Ser Val Gly Asp Ser Trp Glu Ala Ala Leu Lys Arg Ala Gly 
            340                 345                 350         


Ile Arg His Arg Lys Ala Tyr Gln Ser Arg His Thr Tyr Ala Cys Trp 
        355                 360                 365             


Ser Leu Ser Ala Gly Ala Asn Pro Ser Phe Ile Ala Ser Gln Met Gly 
    370                 375                 380                 


His Ala Ser Ala Gln Met Val Phe Asn Val Tyr Gly Ala Trp Met Ala 
385                 390                 395                 400 


Asp Ser Ser Ala Glu Gln Ile Ala Met Leu Asn Gln Lys Leu Ala Asp 
                405                 410                 415     


Phe Ala Pro Leu Met Pro His Ser His Glu Asn Ser Thr Gly Gly Leu 
            420                 425                 430         


Leu Lys Ser Val Ser 
        435         


<210> 1428
<211> 241
<212> PRT
<213> Escherichia coli

<400> 1428
Met Glu Gly Asn Thr Thr Leu Tyr Ala Leu Pro Lys Pro Glu Val Val 
1               5                   10                  15      


Leu Arg Trp Arg Glu Gln Thr Thr Asp Asp Phe Arg Phe Cys Phe Lys 
            20                  25                  30          


Phe Pro Ala Thr Ile Ser His Gln Ala Ala Leu Arg His Cys Asp Asp 
        35                  40                  45              


Leu Val Thr Glu Phe Leu Thr Arg Met Ser Pro Leu Ala Pro Arg Ile 
    50                  55                  60                  


Gly Gln Tyr Trp Leu Gln Leu Pro Ala Thr Phe Gly Pro Arg Glu Leu 
65                  70                  75                  80  


Pro Ala Leu Trp His Phe Leu Asp Ser Leu Pro Gly Glu Phe Asn Tyr 
                85                  90                  95      


Gly Val Glu Val Arg His Pro Gln Phe Phe Ala Lys Gly Glu Glu Glu 
            100                 105                 110         


Gln Thr Leu Asn Arg Gly Leu His Gln Arg Gly Val Asn Arg Val Ile 
        115                 120                 125             


Leu Asp Ser Arg Pro Val His Ala Ala Arg Pro Tyr Ser Glu Ala Ile 
    130                 135                 140                 


Arg Asp Ala Gln Arg Lys Lys Pro Lys Val Pro Val His Ala Val Leu 
145                 150                 155                 160 


Thr Ala Lys Asn Pro Leu Ile Arg Phe Ile Gly Ser Asp Asp Met Thr 
                165                 170                 175     


Gln Asn Arg Glu Leu Phe Gln Val Trp Leu Gln Lys Leu Ala Gln Trp 
            180                 185                 190         


His Gln Thr Thr Thr Pro Tyr Leu Phe Leu His Thr Pro Asp Ile Ala 
        195                 200                 205             


Gln Ala Pro Glu Leu Val His Thr Leu Trp Glu Asp Leu Arg Lys Thr 
    210                 215                 220                 


Leu Pro Glu Ile Gly Ala Val Pro Ala Ile Pro Gln Gln Ser Ser Leu 
225                 230                 235                 240 


Phe 
    


<210> 1429
<211> 131
<212> PRT
<213> Escherichia coli

<400> 1429
Met Val Ser Ala Leu Tyr Ala Val Leu Ser Ala Leu Leu Leu Met Lys 
1               5                   10                  15      


Phe Ser Phe Asp Val Val Arg Leu Arg Met Gln Tyr Arg Val Ala Tyr 
            20                  25                  30          


Gly Asp Gly Gly Phe Ser Glu Leu Gln Ser Ala Ile Arg Ile His Gly 
        35                  40                  45              


Asn Ala Val Glu Tyr Ile Pro Ile Ala Ile Val Leu Met Leu Phe Met 
    50                  55                  60                  


Glu Met Asn Gly Ala Glu Thr Trp Met Val His Ile Cys Gly Ile Val 
65                  70                  75                  80  


Leu Leu Ala Gly Arg Leu Met His Tyr Tyr Gly Phe His His Arg Leu 
                85                  90                  95      


Phe Arg Trp Arg Arg Ser Gly Met Ser Ala Thr Trp Cys Ala Leu Leu 
            100                 105                 110         


Leu Met Val Leu Ala Asn Leu Trp Tyr Met Pro Trp Glu Leu Val Phe 
        115                 120                 125             


Ser Leu Arg 
    130     


<210> 1430
<211> 247
<212> PRT
<213> Escherichia coli

<400> 1430
Met Ser His Arg Asp Thr Leu Phe Ser Ala Pro Ile Ala Arg Leu Gly 
1               5                   10                  15      


Asp Trp Thr Phe Asp Glu Arg Val Ala Glu Val Phe Pro Asp Met Ile 
            20                  25                  30          


Gln Arg Ser Val Pro Gly Tyr Ser Asn Ile Ile Ser Met Ile Gly Met 
        35                  40                  45              


Leu Ala Glu Arg Phe Val Gln Pro Gly Thr Gln Val Tyr Asp Leu Gly 
    50                  55                  60                  


Cys Ser Leu Gly Ala Ala Thr Leu Ser Val Arg Arg Asn Ile His His 
65                  70                  75                  80  


Asp Asn Cys Lys Ile Ile Ala Ile Asp Asn Ser Pro Ala Met Ile Glu 
                85                  90                  95      


Arg Cys Arg Arg His Ile Asp Ala Tyr Lys Ala Pro Thr Pro Val Asp 
            100                 105                 110         


Val Ile Glu Gly Asp Ile Arg Asp Ile Ala Ile Glu Asn Ala Ser Met 
        115                 120                 125             


Val Val Leu Asn Phe Thr Leu Gln Phe Leu Glu Pro Ser Glu Arg Gln 
    130                 135                 140                 


Ala Leu Leu Asp Lys Ile Tyr Gln Gly Leu Asn Pro Gly Gly Ala Leu 
145                 150                 155                 160 


Val Leu Ser Glu Lys Phe Ser Phe Glu Asp Ala Lys Val Gly Glu Leu 
                165                 170                 175     


Leu Phe Asn Met His His Asp Phe Lys Arg Ala Asn Gly Tyr Ser Glu 
            180                 185                 190         


Leu Glu Ile Ser Gln Lys Arg Ser Met Leu Glu Asn Val Met Leu Thr 
        195                 200                 205             


Asp Ser Val Glu Thr His Lys Ala Arg Leu His Lys Ala Gly Phe Glu 
    210                 215                 220                 


His Ser Glu Leu Trp Phe Gln Cys Phe Asn Phe Gly Ser Leu Val Ala 
225                 230                 235                 240 


Leu Lys Ala Glu Asp Ala Ala 
                245         


<210> 1431
<211> 323
<212> PRT
<213> Escherichia coli

<400> 1431
Met Ile Asp Phe Gly Asn Phe Tyr Ser Leu Ile Ala Lys Asn His Leu 
1               5                   10                  15      


Ser His Trp Leu Glu Thr Leu Pro Ala Gln Ile Ala Asn Trp Gln Arg 
            20                  25                  30          


Glu Gln Gln His Gly Leu Phe Lys Gln Trp Ser Asn Ala Val Glu Phe 
        35                  40                  45              


Leu Pro Glu Ile Lys Pro Tyr Arg Leu Asp Leu Leu His Ser Val Thr 
    50                  55                  60                  


Ala Glu Ser Glu Glu Pro Leu Ser Ala Gly Gln Ile Lys Arg Ile Glu 
65                  70                  75                  80  


Thr Leu Met Arg Asn Leu Met Pro Trp Arg Lys Gly Pro Phe Ser Leu 
                85                  90                  95      


Tyr Gly Val Asn Ile Asp Thr Glu Trp Arg Ser Asp Trp Lys Trp Asp 
            100                 105                 110         


Arg Val Met Pro His Leu Ser Asp Leu Thr Gly Arg Thr Ile Leu Asp 
        115                 120                 125             


Val Gly Cys Gly Ser Gly Tyr His Met Trp Arg Met Ile Gly Ala Gly 
    130                 135                 140                 


Ala His Leu Ala Val Gly Ile Asp Pro Thr Gln Leu Phe Leu Cys Gln 
145                 150                 155                 160 


Phe Glu Ala Val Arg Lys Leu Leu Gly Asn Asp Gln Arg Ala His Leu 
                165                 170                 175     


Leu Pro Leu Gly Ile Glu Gln Leu Pro Ala Leu Lys Ala Phe Asp Thr 
            180                 185                 190         


Val Phe Ser Met Gly Val Leu Tyr His Arg Arg Ser Pro Leu Glu His 
        195                 200                 205             


Leu Trp Gln Leu Lys Asp Gln Leu Val Asn Glu Gly Glu Leu Val Leu 
    210                 215                 220                 


Glu Thr Leu Val Ile Asp Gly Asp Glu Asn Thr Val Leu Val Pro Gly 
225                 230                 235                 240 


Asp Arg Tyr Ala Gln Met Arg Asn Val Tyr Phe Ile Pro Ser Ala Leu 
                245                 250                 255     


Ala Leu Lys Asn Trp Leu Lys Lys Cys Gly Phe Val Asp Ile Arg Ile 
            260                 265                 270         


Ala Asp Val Ser Val Thr Thr Thr Glu Glu Gln Arg Arg Thr Glu Trp 
        275                 280                 285             


Met Val Thr Glu Ser Leu Ala Asp Phe Leu Asp Pro His Asp Pro Gly 
    290                 295                 300                 


Lys Thr Val Glu Gly Tyr Pro Ala Pro Lys Arg Ala Val Leu Ile Ala 
305                 310                 315                 320 


Arg Lys Pro 
            


<210> 1432
<211> 9687
<212> DNA
<213> Escherichia coli

<400> 1432
aatcgccggt gtactccgcg tcagaaaggt atacagccac ggcagggaga tcctgctctt       60

caagaaaaac agggcgcccg tcaaaccagg tgaccgtgtc ggtgatctcg gctttcagtt      120

tggccagaat ggctgcacga attgcgctgt gtctgttcat cgcttcaggt ggatcctcag      180

ttggtttttc agggctgcgg aaagttcttt gggcatatcg ctttcaataa ggcgctttga      240

aatagcggtg aaggccacgg tgagcggtgt ctcaagagga actttgacca catcaatcgg      300

ataacgggcc tgacctacgc gccgcatgac ctgccagcgc ccgttcgcaa gctgttggat      360

aaaagcgtta cgaaaggtat agggcccgat tttaaggacg ctgcccgctc cgtttctggc      420

ccctttttta cgcgagagcc tgacgcgcgc cgtgccgagc tttatcgcag gaagattacc      480

gcggttgatt tttatcgacg cgaccgggcg atcgtgacgg gccttgcgca gacgggaacg      540

ctggcggacc agacgaaccg gaagcccctt tttccggtta tcatcaactg ttgcttcttt      600

cgctacagct ttgctcccct ggcttatcgt tcttctggcc accctgttaa gtgcttttgc      660

ggttgcctca ggaacgatta accggctgag gctgttcagg ttctgaatag ccctttccag      720

tcctttcaca gacatagcgc ctcctcattc gagatggatg cggggttttc cgttgaacat      780

gtcatagcgg gtaacgatca ggttcttacc gtcgtagtcg acgctgtcgt ttcggcgtgg      840

ctggtaaagc tcagagaaaa ccaccagcga agtacctgtt cccgacaatg gccccatttc      900

ctcgagttgc tcggcgggaa caacgtcata gctgctgcca ttgatgatcg ctgtctttcc      960

catctttttt atagtggccg cgtccatgcg cgccgccatc cggtcaaagg agttaggcat     1020

tgatcttaac ttcaacaacg gtggtgtttg cccctgcatc ttcccaggcg atgcccgcgg     1080

caacggcgtc cgtttcttcg atcgtgattt tgccgtcctt cagatacacc tgcgccccgg     1140

cagtaaccgc atctgcggat acttttggca ggaggaaaac accctcagta aaaccgtccc     1200

cggtatcgcc agccgggata tcggtaattg ccaccgcgat aagttttcca acaacaaccg     1260

ggtcgccgct gtgaacatcg gttgcaccac tgtttaccag agggatcgtt ttcccgtcct     1320

gcgcatagtt cttagccata acttctccat tcagcccctt tcgaggctgg tttcaggtat     1380

aaaaaaagcc cttacgggcg tctgtttgtc aggactgttt tttactgacc agaggatttg     1440

gtcatgccgc gatagtccag cggcgccacg ccagcatcaa tacgcacttt cgtggcgata     1500

ccatcagtgg tgaagccttc ctgctgatcg atgtatggcg tgtcgacgcc gttgagataa     1560

gcgacctcaa tggtgtcggt gcccttcgcg gcagccagat accaggcttt cgcatcagct     1620

tcatccagac gtggttcggc aatgacttct gcaaagttct ggatagggtt aacgatcccg     1680

gcattgatgt ctgcaccttt aacactggcc gacttgatgg tctgatttgc cagagtttcc     1740

agggcgacgg gcaccagcat gtaggccgga cggatattca gggttcgctc cccctccttc     1800

tgcagacgca tcagcttgcg cgattcgtcc aggctggcca cagaaattgc acccgagctc     1860

aggttcttgt gatcggcatg gaacagcgcc tttccgtctg agagtttcgg gtttttggtc     1920

agaatggcgt aaaccagatc gccaatcgtt gctttcgccg cgcgccccat cttcatcggt     1980

acgtcggtaa gctggttcag atcgtcgttg atgatcgcct ggcgagttac tgagaagatt     2040

tcaccatacg tggcaagcgc gatggtttcg cctttgtcac tggtagtgat gtacttgtac     2100

tcagcccctt cgcgaacctg tcgcagagaa gggaacccac ccataccgac acgatgcgcc     2160

gttttgaagt ccgacagctg gccttttttg gtccactgct cgaaggtttc ctgcgcctcg     2220

tcccagccct gaatcagcgc tttgttcgca acatcaagca gaatgttgcc aaagtcagag     2280

gtgctgtggg tcagcgccag gccaaccatc tgcatcgggt tgtagctggc cacgccgata     2340

cctttttctg tcagggccat acgcgcatac tcgcgcagcg tcataccgtt ataaacgtta     2400

tcccgctcct gaccttcgaa cccggcacgc gccatcagtg cctggcgaat accatccgcg     2460

acgaagttac cgttgcccgc atgaatatgc ggctgagtgg ttttattgga cggcgtggcc     2520

gttttaccga gttctgccag cagcaaatct ttcgccttat cgacggagca atcagggtcg     2580

gccacacact gattctgcag ttccatgtgc ttattaccga acatggcaaa gagatcgccg     2640

atagcgttaa cacgggtttt ctgctcagcc aacacctgcg cgcggatcgc attttcatcc     2700

ggtgccgggt ctgtttttgc ctgcggtgcc tgaggctggg taataaccgg gtcacgctgg     2760

gtagtgttgc gcggcggggt gatcatgttg cgaatgcttt ttggcatttt ttcaaattcc     2820

tcaatacgtt ttgaatgaat acaggccata gcctgaaggg atggtgtcac ctggtcggca     2880

aaacccagtt caaggcactc gctgccgttc atccaggttt cgtcctccag cattaccgca     2940

atttcttcgg tggattttcc ggttttctgt gcataagccg ggataagaac ggattcaacc     3000

ttgtcgagaa gatccgcata gtcgcgcata tcgctcgcgt caccaccagc aaacccccag     3060

ggcttatgga tcatcatcat cgtgttttca ggcatgatga ccggattgcc taccatcgca     3120

atcaccgagg ccatggaggc cgccagaccg tcgatatgta cggtaatcgc cgcgccgtgg     3180

tgcttcagcg cgttataaat agcaattccg tcgaagacat caccaccggg cgagttgata     3240

taaaggttga tgtgggtgac gtccccaagt gcccggagat cattgacgaa ctgtttcgcc     3300

gttacgcccc agtacccgat ttcgtcataa ataaaaatgt cggcctcact gttattgctg     3360

gcctgcatgc ggaaccacga attacttttt gcgctggctt tcggacggtg gcgcgcccgg     3420

ttctttggct tcggcactgg tgcctccttt atcattggcg gggtcggtgt caaacaccag     3480

gccctgttca cggttctcgt caacctcagc tttacggcgt gacttaacat catccgggtt     3540

gcgaccgctg gcacgtatcc agtcggattc agtagcagca ccgccgcgga tctgcgtttt     3600

ccaggcattc gcttctttaa cgggatcaat ccacggcata acgggccccg aataaaccgc     3660

gttataaagc gagtccatat caatgcctct cggcagcttg atttctccgg cagcaatagc     3720

catcttgagc caggctcggt acatgggccg ggtcactgaa ccgatgaacc agtcctgaag     3780

aatcagatag ccgtcggttg actcgacaag ctcctgccgc tgggcactgt acgttccgtt     3840

gtagtttctg gatgtgctgg aaaagctgag gcgactgccg gcggacacgg cacgcagctg     3900

tccgttacga aaagattcga ggttagggtt cgggcgatcg gatttaatca tcccgatttc     3960

ttccccggcc tgcagttcgt catagagcat accgggctga atcatcagct cgcggtcatc     4020

gctgcttgaa tcagaatcga agctctgtcc gtcgcctttt ttgatataca tgccgagtgc     4080

cgcagcaatt ctggcagcag taagctccga gtcctcgtat tctttcagcg cgctcagacg     4140

catcagaaca ccagacaaaa gagacgttcc gcgggtctgg tgcaggcgtc gggtgaattt     4200

gagatgcagc atgttctctg catctatctc tttggtatca aactgacgcc cggatactgg     4260

caggctttta tagacctgat attttttcgg gcgtccccag ttatcgacaa aaacgccctg     4320

attgagctgg gtggcagcat cgctgttcat cggcacaaag tccggctcca gcgcttccag     4380

ccagaacggc acgccagcaa ccggctgaag accatttccg gtaccgcgaa ccagctgagc     4440

aaatacctca ccgtcccgga gccacgttcg cagcatcagc cgctccagca ttgggcgggt     4500

aaactgggtt gtgacatctg gccttacgga ccattcgccc cactttcggc ggatatcagt     4560

ggccagcttt ttagcgatct tcccgttact cagcatcgga tgcggttcaa ctatgatgcc     4620

cttcgcaccc accacccttt cttccagctt gtcgaaaacg ccgatcacca gatcgtggtt     4680

gttatccagc cagcgcgcct gctgcctcag cgaaaccgcc cccatctggc tgagctgatc     4740

ggctgaacga ttttccttct gggctttgtg ggtacgcgtt tgctttaccg cctcatacgc     4800

tttaataact gcgcgggcac gcaggcgtga ggctttccag cctggtgaaa acaggccaat     4860

cgcatcatct aaaaaactca tccaaacctc gccagcctgt agccgggtcg cccacggcgt     4920

ttgttattga gcgttgccag tcgtcgctcc cattcctgac ggccttttct gatttccgac     4980

aggttttcga gcgtcatctg ctgcccgttg aaagtgattg atttcccctc cagaacagac     5040

agctcggctg cagcatagcg gtcgatcatg ttttgaatat ctgctggatt cacacccaac     5100

ctcctgacga agaccacgga ttagcctgct cggttacggg cttctcacgt tttggttttg     5160

gtttagattt cggcgcaggc ggcggggatg gcatttcgcc agcttccgtc tgcgtgtcct     5220

cgatccacgt ttcccgccgt gcccactcag gagctgacgg ccatttgatt ttttcgtaac     5280

cactaaggat ggcgagcgcg tcggcataaa cgagcaggtc aaatgcttcg tttgcgcccc     5340

ggccgggctt actccatttc ccttcattcg agcgttcctc atacgtcagt tcgtcataga     5400

accagctgcc cagccaggcg gggaaatgca catagccagg gccgggtgaa tcacgccaca     5460

gcgcattatt cacccggtct ttaagggcat cggtctggag aagataaaga ggcacatcac     5520

cagtcgcctg tgcgcggcgc gttgatctgc ccgtgttgtc gggaaacgtt cgctggataa     5580

gtttgctgcg cctgacgctg tcccctttga agagatagat acgcttaccc agcccctcac     5640

ggcgacatct gcgccagaac ttgtaggcat tatccgtcac gccatcttcg ccccctgagt     5700

ccacggccat cgacatcagc cgcatgccct ttgatgggtc agctgcgagc ggccacgttt     5760

tatcaaagac gtcagtgagt aaaagatccc agtcctccgg atagctcgcc ggatccacct     5820

gaatgctttc accgttgccg tcgcagcgca gcgaatgccg gatgttgtaa cggtcaacta     5880

tccagcgctc acccatactt ccataacccg taatctgcac aacaaagcgc cggttgcgcc     5940

cggcctgcac gtccacggtc gcagtgagaa actgcacgcc gttcggtacc gaacgttttg     6000

ggacgtcttc ggcacgctgc tcgagcaatt cacttttacg ctgctccatg ctggctcgcg     6060

gcaaataggg cctgccgaaa tcggtgttga tcaccgtctt cagggtttct tcgctgcgcg     6120

tggattcata ttcctgctcg gcggtcagaa acttataaat aagctgcgcc caggtctggt     6180

aagcagctgc cggaccttcc atccagaagg aggcaatacg ggaacgacgg ccatcaccgc     6240

taaccaggcc tttcctgtcg atggtttgcc cgtcccggag ccagacacat ttcatgttaa     6300

gcgcacgctt catgtccggt gtgatcctgc ctttacaggc agggcactga agaaacgccg     6360

cttcgctggc aagcacagga tcgctgctgt cgcggtatcc ggtcatattg tccatttccg     6420

gctggaaata ttcgccgcaa tgcgggcatg gccagtaaag acgacggcgg tcaccacggt     6480

tatagagcga taaaattccg gtggtcggag gggcttcatg gggcgtggag cgccgccatt     6540

ttgtgtctct gatatccctc ccgggcgagc tctcaaccag cgtcatcccg gaggacatga     6600

atgtcgtggt tcgtttcgat gccagtgaaa aagcatcccc ctccccgtcg atatcttccg     6660

gaaagcggtc ataatccgtc agcgccacac ttttatagtc cgaggacgac atgatattga     6720

cggatggcca gcccagcttc agatagttac cggcgcggaa tgtacggtcg tagacgttgt     6780

tatcgttacg tcttgggctt agccgggttt taacttcagg gctacagcga aaagtacggt     6840

ccaggcgttt tttggaatgc tcgcgcgctt tttcctcaga tacctgaatt acaagcatat     6900

ctgccggatc gcagacaatg ttataaacga tccagccgtc aatcagcccg atggttttac     6960

ccgttcgcgc tgggcccaca aacacaaccg catcgtattc acgcgatgcc agacagttca     7020

tcggctcaat cacatagggt gccagatccg gatcccacgg aactgagttt cccgccccca     7080

ttggcacgcg catataagta ctgaccgcat cggccaccgg catacgacgc ggggctcgta     7140

aaataccgga aacatcgcgg cggatgtccc tggcggatgc ccgctttgcc atcagtcctc     7200

ctcaggctgc tcctcctctt ttccagcgtc ctgcaccttc tccgccatct ggtcgcgcag     7260

atcatcgata acgctttgca cacgaactac cgcagcaggc gttaaagcac agtcgcgctc     7320

gagcacatcc gggagggttt caagtaccat gacgacggct ttcgccatca atgagaattc     7380

tcgcgccact tcatctgcgg gtattaactg ccccgtatcc tgttcgaact tcagcctctc     7440

gttctctgct ttccagtggg acagcctgtc agaagggggc atatcgtcga tgttggccga     7500

aacggtaggg atcatcagtt cggtcagaat gtcggtcacc agatagagct ttaacttgct     7560

attgctgcct ggagcaggtt caacattttt cagtctcgcg gcaaccgtct gacggtgtac     7620

gccggttatc cctgccagct ggttgatatt gagttttaaa gtggcaattt cctggtccat     7680

gatggtgaac actttttgaa cgattcgaca tgttgcgaaa atggcctcta attaaatcaa     7740

agacctgcgc acatgatgat gatgaccctg gatccgaaaa actagccgtt tcccgcgagc     7800

acgccgcccc gtggcagggt ccccctccgg gagtaccttt tgataataat tatcaattgc     7860

acactatcga cggcactgct gccagataac accaccgggg aaacattcca tcatgatggc     7920

cgtgcggaca taggaagcca gttcatccat cgctttcttg tctgctgcca tttgctttgt     7980

gacatccagc gccgcacatt cagcagcgtt tttcagcgcg ttttcgatca acgtttcaat     8040

gttggtatca acaccaggtt taactttgaa cttatcggca ctgacggtta ccttgttctg     8100

cgctggctca tcacgctgga taccaaggct gatgttgtag atattggtca ccggctgagg     8160

tgtttcgatt gccgctgcgt ggatagcacc atttgcgata gcggcgtcct tgatgaatga     8220

cactccattg cgaataagtt cgaaggagac ggtgtcacga atgcgctggt ccagctcgtc     8280

gattgccttt tgtgcagcag aggtatcaat ctcaacgcca agcgtcatcg aagcgcaata     8340

ttgctgctca ccaaaacgcg tattgaccag gtgttcaacg gcaaatttct gcccttctga     8400

tgtcagaaag gtaaagtgat tttctttctg gtattcagtt gctgtgtgtc tggtttcagc     8460

aaaaccaagc tcgcgcaatt cggctgtgcc agatttagaa ggcagatcac cagacagcaa     8520

cgcgccacgg aaaaacagcg cataaagcac ttcattagca gcgccagata gcgtaatgat     8580

tttgttactc atggaatatt tccttttagg cgtgagcctg tcgcacggca atgccgcccg     8640

agaggtaaac gcaacctaac ggcatcaccc aggctcacta ctgaaagact ctctttgatg     8700

tgcgcgtgcg atgcgcgtag aagactgatt tatcaacctg tctttatatc aggattcatt     8760

acctgactat ttgtgggtaa agttcgtagt gcgctgatcg tgcaaaatga ttttagttgg     8820

gaacagttcg caactctgtc ccataaaaat cagcatattc ccatctatcc catatccagc     8880

gcattgacca tcgggatact gaagggagat tccatcatct cttagaaaga tcaccatctc     8940

ttttgtttca atttgcatat agctacctgg aggatttatg aatgcaagga ttttcatgga     9000

ctattaccat gagattgatt ttccatcttt attcgcgaga gcagtggaaa gcgatgacga     9060

tgtgggtact acattgcgca ttcacctact ttgtgagcgc atggtcgaag catggatatg     9120

cgcatgctgt gactgccaag atctctttgg aagagataaa aacaaacttt taatcgaatg     9180

taatactaaa atatccatgg cgggaaacct gggaatcccc ccggaactta tgaaatcact     9240

taaaaccatc aactcaatgc gtaatgacct tgcacacaat ccatcaatac aaagcattgc     9300

tgattcaagg atccagagcc tgaaggatac tctgactgaa tactttaaac agcatccaac     9360

ggaacccagc atggaagaat caaaactggg tatttttaac gccgagaatc aattaaccga     9420

agaagtttcc ttagatagtg acagttcaaa aaacagactt aagttaatct tgctgttcag     9480

caagttaatg caggcgttaa tgcaattagt tgcagctaat cataatgggc gctgggataa     9540

ccaatttagc caattcgttt accatgtgac catgaacgca acaaagagat aaatccaagc     9600

ccgttttgta cgggctgttg cattatcaca ggcactcagt gaatgcctgc tgtaatgccg     9660

ctagtcgtcg agttgcaaca caccgtg                                         9687


<210> 1433
<211> 49496
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1433
aggcctctcc tcgcgagagg cattttttat ttgatgggat aaagatcttt gcgcttatac       60

ggttggattt cgcccggttt gcgagttttc agcaatttta atatccaggt gtattgttct      120

ggtcgcggac caacaaaaat ctcgacttct tcattcatcc gccgcgcaat cgtatgatca      180

tccgcctcta acagatcatc catcggtggg cgcacctgaa tcgtcagacg atgcgtcttg      240

ccatcataaa tcggaaatag cggtacaacg cgcgcacggc acactttcat caaacgacca      300

atcgcgggca acgtcgcttt ataggtggca aagaaatcaa caaattcgct gtgttctggg      360

ccatgatcct gatcgggtaa ataatatccc cagtaaccct gacgtaccga ctggatgaat      420

ggtttaatac catcatttct cgcatgcaga cgaccaccaa agcgacggcg caccgtgttc      480

cagacataat caaaaaccgg gttgccctga ttatggaaca tcgctgccat tttctgccct      540

tgcgaggcca tcagcatggc aggaatatcg acggcccaac cgtgcggcac cagaaaaatc      600

actttctcgt tattacgtcg tatctcttcg atgatctcca gcccttgcca gtcaacgcgc      660

ggctgaattt tctccggccc gcgtattgcc aactcagcca tcattaccat cgcttgcggc      720

gcggtggcaa acatctcatc tacaatcgct tcgcgttcag cttcactacg ttctggaaag      780

cagagcgaca gattgattaa cgcacgacgg cgtgagcttt ttcccagtcg tccggcaaaa      840

cgtcccagcc gtgccagaat gggatcacgg aactttggcg gcgttaaagc gatacccgcc      900

atcgctgcta cgcccagcca tgctccccag tagcgcgggt ggcgaaagga tttatcaaac      960

tcaggaatgt attcgctatt attttttttc gtttccatgc ttttccagtt tcggataagg     1020

caaaaatcaa tctggtgata gtgtagcggc gcaacttgcc ccgcaccaaa taaaaaagcc     1080

ggtactgact gcgtaccggc tgcgaatgga tgttaattaa tcaaaccgta gctgcggcac     1140

aatctctttg gcctgtgcca ggaattcgcg acgatcggag ccggtcagcc cttcggtacg     1200

cggcagtttt gccgtcagcg ggtttacggc ctgctggttt atccatactt catagtgcag     1260

atgcggcccg gttgaacgtc cggtattacc ggaaagcgcg atacggtcgc cacgtttcac     1320

cttctgtccc ggtttcacca ggatcttgcg caagtgcata taacgcgtgg tgtagctgcg     1380

accatgacga atagccacat aataacctgc tgcgccacta cgtttggcaa ccaccacttc     1440

accgtcaccc actgaaagca ctggcgtacc ttgtggcatg gcaaaatcaa cacctctgtg     1500

tggcgcaacg cgaccggtca ccggattagt acgacgcggg ttaaagttag atgagatacg     1560

gaactgtttc gccgtcggga atcgcaagaa tcctttcgcc agaccagtac cgttacgatc     1620

gtagaatttg ccatcttcag cgcggattgc gtaataatct ttaccttctg aacgcaaacg     1680

tacgcccagc agctggcttt gctcacgttt accatcaagc atttctcgtg acattaacac     1740

cgcaaattca tcgccttttt tcagtttgcg gaaatccatt tgccactgca tggctttaat     1800

cactgcgctc acttcggcgc tggttaaacc ggcgtttctg gcgctggcaa caaagcttcc     1860

cccgacggta cctttcagca gattgttgac ccactctcct tgctgcattt cgctggtcat     1920

tttaaaaccg ttagcggcag tacggtcata ggttcgggtt tcacgacgag acacttccca     1980

ggtgaggcgc tgcagttcgc cgtccgcggt taatgtccag gagagttgtt gaccgatttt     2040

caggttacgc aattctttgt cggcagcagc cagttgggtg atatcaccca tatcaatacc     2100

atactgattg agaatgctgc ttagcgtatc gccagtggaa acaacatatt catgcacgcc     2160

cgcttcaccg gcgattttgt catccagttc gtcctgggga atggcttcat cttcttgtgc     2220

agcttgatca atcggctcac tggcttcagg taagagcgaa cgaatttcgt tctgttccag     2280

ctcaatggtt ttgacaattg gcgtggcatc gcggtgataa acatagggcc gccagacagc     2340

gacggccaga gtaagaacgg tgagcgaccc caacataacg cggtgtggtc gcggtaaatt     2400

attaaacgcc agggcgacag agcgggctat ctgttgcacg taatcacttc ctcattaatc     2460

tcctttcagg cagctcgcat actggttggc taattgattc aggaattctg aatagcttgt     2520

tttacccagt ttgatattcg tccccagggg atccaacgtt cccatacgaa cggatgtccc     2580

tcgtgcgacg ctctcaacga ccgctggcct gaactgtggc tcagcaaaaa cgcaggttgc     2640

tttttgctca accaactgtg ttcttatttc atgtaaacgc tgcgcgccag gttgaatctc     2700

agggttaacg gtaaaatgac caagcggtgt cagtccgaac tgtttttcga aatagccgta     2760

agcatcgtga aaaacgaaat aacctttccc cttgagcggc gcgagctcgt taccaacctg     2820

cttttcggtt gaggctaatt gtgcctcaaa atccttcagg ttggcgtcaa gtttggctcg     2880

actttgcggc ataagttcca ctaattttcc atggattgca accgctgtag cccgcgctat     2940

ctctggggaa agccaaagat gcatgttgaa atcgccgtga tggtgatctt cgtcactttt     3000

ttccgcgtgg tcgtgatcat catcatcgcc gtgaatactt ttcatcagca gcggtttcac     3060

attctctagc tgcgcaatcg ttacctgttt cgcttcaggt aatttactta ccggtttttg     3120

catgaacgct tccatctccg ggccaaccca aacgactaag tccgcgttct gtaagcgttt     3180

tacatctgat ggacgcagtg aataatcatg ttctgaagcc ccgtcaggta gtaaaacctc     3240

cgtttctgtt accccatcag caatggcaga agcgatgaac ccaacgggtt taagcgaagc     3300

gacaacggca gcatctgcgg cctgtgttgc accgccccag agagcggcgg ataatgctgc     3360

gaaaagaagc gtttttttat gtaacataat gcgaccaatc atcgtaatga atatgagaag     3420

tgtgatatta taacatttca tgactactgc aagactaaaa ttaacatgac aagtctggtt     3480

tccctggaaa atgtctcggt ttcttttggc caacgccgcg tcctctctga tgtgtcgctg     3540

gaacttaaac ctggaaaaat tttgacttta cttgggccaa acggcgcagg taagtcgaca     3600

ctggtacggg tagtgctcgg gctggtaaca cccgatgaag gggttatcaa gcgcaacgga     3660

aaactgcgca tcggctatgt accgcagaag ctgtatctcg acaccacgtt gccactgacc     3720

gtaaaccgtt ttttacgctt acgccctggc acacataaag aagatatttt gcctgcactg     3780

aaacgtgtcc aggccgggca tctgattaac gcaccgatgc aaaagctctc gggtggcgaa     3840

acgcagcgtg tactgttagc gcgagcattg ttaaatcgac cgcaattatt agtgctggat     3900

gaacccactc agggcgtgga tgtgaatggt caggtggcgt tatatgacct tattgaccaa     3960

ctgcgtcgcg aactggattg tggcgtttta atggtatctc acgatctgca tctggtaatg     4020

gcaaaaaccg atgaagtgct ttgcctgaat caccacattt gttgttccgg cacaccggaa     4080

gttgtttccc tgcatccgga gtttatttct atgtttggtc ctcgtggtgc tgaacaactg     4140

ggtatctatc gccatcatca taatcatcgt cacgatttac agggacgaat tgttttgcgt     4200

cggggaaatg atcgctcatg attgaattat tatttcccgg ttggttagcc gggatcatgc     4260

tcgcctgtgc cgcgggtccg ctgggttcgt ttgtagtctg gcgtcgtatg tcttatttcg     4320

gtgatacgct ggctcatgcc tcattacttg gcgtcgcgtt tggtttgttg ctggacgtga     4380

atccattcta tgcggtgatt gccgttacgc tgctgctggc gggcggtctg gtatggctgg     4440

agaagcgtcc acagctggcg atcgacacgt tattagggat tatggcgcac agtgccctgt     4500

cgctgggcct ggtggtcgtt agtctgatgt ctaatattcg tgttgatttg atggcttacc     4560

tgttcggtga tttactggca gtgacgccag aagatctcat ctctattgcg attggcgtgg     4620

tcatcgtggt ggctattttg ttctggcaat ggcgcaattt gctgtcgatg acgattagcc     4680

cggatctggc gtttgttgat ggtgtgaaat tacagcgcgt gaaattgttg ttgatgctgg     4740

tgacggcatt gacgattggt gtagcgatga aattcgtcgg cgcgttgatt attacttcac     4800

tgctgattat tcctgctgct actgcacgtc gctttgcccg cacgccggaa cagatggctg     4860

gtgtcgctgt tttggtgggg atggtggcag tgactggcgg tttaaccttt tccgcatttt     4920

acgatacacc tgcaggcccg tcggtggtgc tatgcgcggc actgttattt attatcagta     4980

tgatgaaaaa gcaggccagc taatctgtcg ctgaacacat ttgtcggatg cggcgcgagc     5040

gccttatccc acctgcggtt cgctatctct ggtaggcctg ataagacgcg aacagcgtcg     5100

catcaggcac actgccagtg tcggatgcgg ctcgagcgac caatccgact tacggcattt     5160

ctggcggcgt gatgccgaag tggttccacg cccgcactgt cgccatacgc ccgcgcggtg     5220

tacgctgcaa aaagccttgc tgaatcaaat aaggttccag tacatcctca atggtttcac     5280

gttcttcgcc aatggctgcc gccaggttat ccagacctac cggcccacca aagaacttat     5340

cgattaccgc cagcaacaat ttgcggtcca tataatcgaa accttcagca tcgacattca     5400

acatatccag cgcctgagca gcgatatctg ccgagatggt gccatcgtgc ttcacttcag     5460

cgaaatcacg cactcgacgc agcagacggt tggcaatacg tggcgtaccg cgcgcacgac     5520

gagcaacttc cagcgcgccg tcatcactca tctcaagccc cataaagcgt gcgctgcgac     5580

tgacgatata ttgcagatcc ggcacctgat aaaactccag acgttgcaca ataccaaaac     5640

gatcgcgcaa cggtgatgtc agcgaacctg cgcgcgtggt tgcaccaatc agggtaaacg     5700

gcggcaaatc aattttaatg gagcgtgccg ccggaccttc accaatcatg atatccagtt     5760

ggtaatcttc cattgccgga tacaacacct cttccaccac tggtgaaaga cggtggatct     5820

catcaataaa cagtacatcg tgtggttcaa ggttagtgag cattgctgcc agatcgcccg     5880

ccttttccag caccggacca gaagtcgtgc gtaaattaac gcccatttca ttggcgacaa     5940

tattggcaag cgtagtttta cccaaccccg gaggaccaaa aatcaataga tgatcgaggg     6000

catcgccgcg cagtttcgct gctttgatga aaatctccat ctgcgaacga acctgcggct     6060

gaccaacata ctcttccagt aatttagggc gaatggcgcg atctgccaca tcttccggca     6120

aagtggtacc ggcagaaatc agacggtctg cttcaatcat cctttacctc ataacgcggc     6180

gcgtagggct tcgcgaatta atgtttcact gctggcgtca gggcgagcga ttttgctcac     6240

catgcggctt gcttcttgtg gtttatagcc cagtgccacc agcgcagcaa ccgcttcctg     6300

ttcagcatcg tcggtcgccg ggctggcagg agacgtgagt accaggtcgg cggctggcgt     6360

aaagagatcg ccatgcaaac ctttaaatcg gtctttcatt tcgacaatca agcgttcggc     6420

ggtttttttg ccaatacccg gcagtttcac cagtgccccc acttcttcac gctcaacggc     6480

attaacgaac tgctgcgctg acattccgga gaggatcgcc agcgccaact tcgggccgac     6540

gccgttggtt ttgatcaact ctttgaacaa cgtgcgctct tgtttattgt taaaaccgta     6600

cagcagttgc gcgtcttcac gcaccacaaa gtgggtgaaa acgatcgctt cctgacccgc     6660

ttcagggagt tcataaaaac aggtcatcgg catatgcact tcatagccta cgccgcccac     6720

ttcaattaac accagcgggg gttgtttttc aatgatgatg cctctgagtc tgcctatcac     6780

atgacgctcc tgcgtaatga atcaaagata atgctgtatg ataaaaaaat gctggataga     6840

tatccagcga aggatgaaga aaacttgcga ggtgtctcga tgatctgaaa aatggcgcag     6900

tataatttat tctacagatt atattggaag caaatattta aatattacat attcagcgaa     6960

gaaatgtgta ataaaaatac acattgcgac ccctgaaaaa aataaatttt ttatgctatt     7020

acgtatattc atatctattt caatggaatg acaacgtgaa tattaattat cctgctgaat     7080

atgaaattgg tgatatcgtc tttacatgta taagtgctgc cttatttggt caaatatcag     7140

ctgcatcaaa ttgctggagt aatcacgtcg ggatcattat cggtcataac ggtgaagact     7200

ttctggttgc agaaagccgt gttcccctct caaccatcac tacgctatcc cgttttatta     7260

aacgctctgc taatcaacgc tatgctataa agcgattaga cgccggacta acagaacaac     7320

aaaatcaacg aattgttgaa caggttcctt cccggctacg caaaatttac cacaccggtt     7380

ttaaatacga atcttcgcgc cagttctgtt caaaatttgt ttttgatatt tataaagagg     7440

cgctatgtat tccggtgggt gaaatagaga cgtttggaga attgttaaat agcaatccaa     7500

atgcaaaact cactttctgg aaattctggt tcttaggttc tattccgtgg gagcgtaaaa     7560

ccgtcacgcc agccagtttg tggcatcatc cgggtttggt gttgattcac gcggtgggag     7620

ttgaaacgcc tcagcctgaa ctgaccgagg cggtataact taacgcagtc gccctctcgc     7680

caggttcagt cgcgattcgc tcatttgcat cgcattctga ctaacgtggc agtgggtgat     7740

ggcaatcgcc agcgcatcgg cggcatccgc ctgtggatta gcgggcagtt tcagcaaggt     7800

gcggaccata tgctgcacct ggcttttttc ggcactacca atacctacca ctgtttgctt     7860

tacctgacgt gccgcatatt caaataccgg caattcctga ttcaccgccg ccacaatcgc     7920

cacgccgcgc gcctgcccca gtttcagggc tgagtcagcg ttcttcgcca taaagacctg     7980

ttcaatggcg aaataatcag gctggaattg ggtgatgatt tccgtcacgc ccgcatagat     8040

gagcttcaga cgagacggta aatcatccac tttggtgcgt atgcatccgc tacccaggta     8100

ggacagttgc ctgcctacct ggcggatgac gccatagccg gtcacgcgcg aacccgggtc     8160

aatgccgaga ataatagcca tcacgcgtct ccgttttgct gtttagcagg cctcatcaga     8220

gagtcgctgc aacctcatca gagatttcac cgttatggta aacttcctgc acgtcgtcgc     8280

aatcttccag catatcgatc agacgcatca gtttcggtgc ggtttctgca tccatatcag     8340

ctttggtgga cgggatcatg gaaacttccg cgctgtctgc tttcagacct gccgcttcca     8400

gagcgtcgcg tactttgccc atttcttccc atgcagtgta gacatcaatc gcgccgtcat     8460

cataggtcac aacgtcttca gcaccggctt ccagggctgc ttccatgatg gtgtcttcat     8520

cgcctttctc gaaggagatc acgccttttt tgctgaacaa ataagctacg gaaccatcag     8580

taccgaggtt accgccacat ttgctgaatg catgacgcac ttcagcaacg gtacggttgc     8640

ggttgtcaga cagacattca atcatgattg ccgtgccgcc aggaccgtaa ccttcgtaga     8700

tgatggtttc catgtttgca tcatcatcac cgcccacacc tcgtgcaatt gcgcggttca     8760

gagtgtcacg ggtcatgttg ttagacagtg ctttatcaat tgctgcacgc aaacgcgggt     8820

tagcgtccgg atcaccaccg cccagcttag ccgcggttac cagctcacga atgattttag     8880

tgaagatttt accgcgctta gcatcctgcg cagctttacg atgtctggtg ttggcccatt     8940

tactatgacc tgccataaaa atatctccag atagccctgc ctgttcaggc agcgttaatt     9000

acaaactgtt caatcgcctg ccggttgctc caggacttag tgagcgccgc cgcagcagac     9060

gcatcaagcc acttgtaagc cagatgttca gtgaaaacga tctggcgctc gtgcggaagc     9120

gcaagacaga accatgattc cgtattacgc gtcacgcccg gcgcatagcg atgacgtaaa     9180

tgtgaaaaaa tttcaaactc taccgtgcgc tgacagtcaa ttaaggtcag ttgttcagcg     9240

acaacatcaa tggtgacctc ttcctttact tcgcgcatgg cagcttgcgg cgcggtttca     9300

ccctcttcca cgctgccggt taccgactgc cagaaatcgg gatcgtcacg ccgctgcaac     9360

atcagcaccc gtttcgtatc ttgtgcgtag atgaccacta agatcgaaac gggacgctta     9420

taagccatat cagttattct cagccttctt cacaacctga atgctcagct cagccagtgc     9480

agtcgggtta gcaaagctcg gcgcttcagt catcaaacac gctgccgccg tggttttcgg     9540

gaaggcgata acgtcacgga tattgtcggt gccggtcagc agcatcgtca gacggtcaag     9600

accgaatgcc aaacctgcgt gcggcggagt accgtatttc agggcgtcga gcaggaagcc     9660

gaatttctcg cgctgttcct cttcgttgat acccagaata ccaaacaccg tctgctgcat     9720

atcaccatta tggatacgca cagaaccacc gcccacttcg taaccattga tgaccatatc     9780

gtaagcgtta gccaccgcat tttccggtgc agctttcagt tctgctgccg tcatgtcttt     9840

cggtgaggtg aacggatggt gcattgctgt caggccgcct tcaccgtcgt cttcaaacat     9900

cgggaagtcg ataacccaca gcggtgccca tttgctttcg tcggtcagac caaggtcttt     9960

acccactttc aggcgcagtg cgcccatcgc gtcggcaaca attttcttgt tgtcggcacc    10020

gaagaaaatc atatcgccat cttgcgcgcc agtacgctcc aggatggctt cgatgatttc    10080

tgcattaagg aacttcgcta ccgggctatt gataccttcc agacctttcg cgcgttcgtt    10140

aactttgatg taagccagac ctttcgcgcc gtagatttta acgaagttac cgtattcgtc    10200

gatctgctta cgggtcaacg atgcgccgcc cggaacacgc agagcggcaa cacggccttt    10260

cggatcgttc gccggacctg caaatactgc aaactcaaca gatttcagca gatcggcaac    10320

gtcggtcagt tccatcgggt tacgcagatc cggtttatca gaaccataac ggcgttctgc    10380

ttctgcaaag gtcattaccg ggaaatcgcc cagatccacg cccttcactt ccagccacag    10440

atgacgcacc agcgcttcca tcacttcacg cacttgcggc gcggtcatga aagaagtttc    10500

cacatcgatc tgagtaaatt caggctgacg gtcagcacgc aggtcttcgt cacggaagca    10560

tttaacgatc tgatagtagc ggtcaaagcc ggacatcatc agtagctgtt tgaacaactg    10620

cggggattgc ggcagcgcgt agaatttacc tttgtgcaca cgagaaggca ccaggtagtc    10680

acgcgcgcct tcaggcgtgg ctttggtcag catcggagtt tcgatgtcga ggaagccgtg    10740

gtcatccata aaacggcgca ccaggctggt gattttagcg cgggttttca ggcgctgagc    10800

catttccggg cgacgcaggt cgaggtagcg gtatttcaga cgcgcttctt cggtgttgac    10860

gtggttagag tcaagcggca gaacatctgc acggttgatg atagtcagcg aggacgccag    10920

tacttcgatt tcgccagtcg ccatatcgcg gttaatattt ttttcgtcac gcgcacgtac    10980

ggtgcccgtg acctgaatgc agaactcatt acgcagttca gaggccagct ttaacgcgtc    11040

cgcacgatcc ggatcgaaaa atacctgcac gataccttcg cggtcgcgca tatcgatgaa    11100

gatcaggcta ccaagatcac gacgacggtt gacccaacca cacagagtca cctgctgccc    11160

cacgtgggac aaacggagct gtccacaata ttctgtacgc atgagatatc ccttaactta    11220

gctgccggcg gatgccccct gctgcgcagg tgaccaagtc gcagcgttag ctgtatgtca    11280

caactgaatg aaaaaaggcg gctattatac tggaaattct gccgcaccgt aagagcctgg    11340

cccgcgctgg aacgcctcgt taccacttta tatcgggcct gaaatcagac tctacgccag    11400

tttgctataa aggtgttgcc cgaactcata aaaattaaca aaatttgtcg ttccgccatc    11460

ggctaatcgc attaaggtga gaggcacgat tttgttttgt caggagtcat catgcttgaa    11520

cttaatgcta aaaccaccgc gctggtggtg attgatttac aagaaggcat cttgcctttt    11580

gccggaggtc cacatactgc cgatgaggtg gttaatcgcg ccgggaagct ggcggcgaaa    11640

tttcgcgcca gcggtcagcc cgtgtttctg gtgcgcgttg gctggtctgc cgattacgcc    11700

gaagcattaa aacagccggt tgatgccccc tcccccgcaa aagtgttgcc cgaaaactgg    11760

tggcaacatc ctgctgcatt aggtgcaacc gacagcgata tcgaaatcat caaacgtcaa    11820

tggggtgcgt tttacggtac ggatctggag ttgcaattac gccgccgggg tatcgataca    11880

atagtgttat gtgggatctc gaccaatatc ggtgttgaat ccaccgcccg caatgcctgg    11940

gaactcggtt ttaatctggt gattgccgaa gatgcctgta gcgccgctag cgccgagcag    12000

cacaataaca gcattaatca tatctacccg cgcatcgccc gtgtgcgtag cgttgaagag    12060

atcctcaacg cgttatgatt tacatcggtt tgccacaatg gtcgcatcct aaatgggtgc    12120

ggttggggat caccagcctt gaagagtatg cccgccactt taactgcgtg acgcgggcat    12180

tttaaaaatc actaaagaac gcccaagagc atgtgttttc tttagtttat tcaatgcatt    12240

aaaaaatagt ttcgcatgaa attcggtaaa cttcatgtgt gcaataatgt cccattcatg    12300

ccccaaaatg ccccaaagca gacatttttg ccccaagtat gccccacaag tcacgtcttc    12360

aagtcgtcta tatccatagc acaccgagtt acattcttgc atccggggtg tcgacaatac    12420

ctactttatt gagtgtgcga gaattaccag gaacctttcc acaatgtagt agtctaatag    12480

tcgaatccat ctaacattaa gaagcgttat gatcactagc ctctcattga tatcttctgt    12540

aatagtcact ctatgtatca tggtgttcgc tacagtaaag gtagggattg gtttgtctaa    12600

caatccagac agaaatgata attaacctca accacgtaac cacacttcat acttcatact    12660

tcacttaaca gtgaagtgct cacatcaccg ggcagtcatc aaactccgca ttcctggcat    12720

cattaatgat gtacgtgatc actccaaata tagcgggtgc agaactgtaa ccatcatcat    12780

ctgctggcag cgcttccctt ctcccgttat ccagattaac caggtgcggc tgaggatgag    12840

tccgatatcg cttgatcctg aattccccgt cgattgcaca tatcagcagt gaaccatcgc    12900

aggcagtaag tgacgcatcc acaacaagca acgctccctg gattatccct tccctgaaat    12960

gtgaacgcga tgcccgcatg aaataagtcg ctgcgggctg actgattagc tgctgatcga    13020

gggagattcg tgtttcaaca taatctgccg caggtgaagg aaatcccatg tttacgccct    13080

ctcttgaata ccggataaaa acacagtata aatactgtat atccatccag caaagaggca    13140

atgagcaatg ttcgtggaac tcgtttatga caaaaggaat tttgatggtc tgcccggtgc    13200

aaaagatatc attctgggcg agttaactaa gagagttcac cggatcttcc ccgatgctga    13260

tgttcgggtt aaaccgatga tgacactgcc ggcgatcaac actgacgcca gcaagcatga    13320

gaaggaacag ataagccgta ctgttcagga aatgtttgaa gaggctgaat tctggttagt    13380

gagtgagtaa agattttcaa tgcccgccac agttacgtat tgattatgct gtggaggata    13440

ttcattttcg taaacgttgg tttgggagaa gcggcaaaac ggaatgtggg aacaggggaa    13500

aatcagatac cagatatgtc tgcatttcca tctggcaata actggtttca gttaccaagt    13560

ggacatatcg ttcagatatt ttccatgaac gttcttggtg cagatgctaa tggcacgtca    13620

gctaattacc ccattgcttt tccaacaacg atgattgctg tcagtgctct atggtctgat    13680

gggactgtag caaatgcacc gacatacaag atgatgggga acacgactaa cagaacaact    13740

ttgacgataa aagtatcagc cagctcaggt acttacggga caatgattat tgcggtggga    13800

cgataatatg aataaataca gttactctcc ttcagaaaat gccttttatg ctgttgcgtt    13860

aaaaaatacc tatgaattga gtggcacatg gccagctgat gcattagata ttcctgatga    13920

catttctgta aaatatatgg cggaaccgcc acaagggaaa atccgagttg caggggaaaa    13980

tggttttccc acatgggctg aaatacctcc accatcacat gaggaactta ttgaacaggc    14040

cgaatcagag aggcaattat tgattaacca ggccaacgaa tacatgaaca gtaaacaatg    14100

gcccggtaaa gccgctattg gtcgtctgaa aggcgaggaa ctggcacaat ataattcgtg    14160

gctggattat ctggacgcac tggaactggt cgatacttcc ggtacgcccg atattgaatg    14220

gcctacgcct ccggcagttc aggccagatg acatccggcg cggtgctggt atctgttgca    14280

gtcaccgcgt caatgtaatc cagcacggcg ttaagtcggg ttgtttctgc ctgagtcagt    14340

ttccgtccgg cctgtaattt cagctgaatc agactaatgg aagccattgc tgcatcaatc    14400

agtgattggc gctgtgcttc tgccgcttct actgaggcac cgtgttgtgc ctcagtatct    14460

gtcacccatt tctcaccatc ccatttatca tatggcgtta acggtgaaag cgtgacataa    14520

ccgtttttga tggcaccgat ataatccact gtaacagctg cgccattttc gattgagtaa    14580

acagtctcat tgcgatggtc ttcctcatgg ctccatccct tacctgtaaa tactgccact    14640

cttcccggaa tgttttcgtc cgggtcaata ccagtggaac aggcgggcat acttacgcca    14700

gtattaatat attcatcaga ccagcccgta tattcagacg ttactgcatc ataataaaaa    14760

caacgcatat cacccggcac tgcagccagc ccattttcat caaaaacagg tttcattatt    14820

tagccctcac cagaaagtta aatgcaatat ttcgcggtct gacagcaaca aaattcacac    14880

catcacccac agagttactg ttgaaattaa atcgtgaaaa tcctggctga tttccggcga    14940

tgccatcatg aaagttaatt gcgtgtccag cacctccgcc tatattcccg gcaaactgag    15000

aaaagtttgt agcttcctgc cagcttaata attcgcgacc accatctgca cctcgcccgt    15060

catcccagac acgaatgaaa tcaccgcggg cttcaggtaa taccagcgaa ggaaacactt    15120

tcgccagcac aggataatca gtggcagaga atttcgcgcc gttgaacttc aaaaacacca    15180

tactggacca gctgtcgatt acagtatttg gcattgcagc ggacggccag aagaacggaa    15240

cgccaatagc tggagaacct tctcccaaac caaggtttgt gcgagcgtct gcggcattcg    15300

ttgcgccggt tccgccgtct gcgacagtaa ccgcaccgtt gctccctttc tgcgcaagtt    15360

taccgatgcc tgggatggtt acggcggtgc cgttgatggt aactgtgatg ctttggtttg    15420

ctgaggtggt ggcgaacgtc tcccacgcgc caatattctc gtcgtactct ttgatgagct    15480

gtgacatggc ctgcgccagg ccgtcgactg agatattgtc cgacacaagg attccatact    15540

tctggccgct cagcgccggg gaaactgctg gcgtaaccgt cattgacgtg gcgctgttca    15600

cggatgaaat ctgaaacagc tgcaccgggt tagacatcac gataatcgtc tggccagcgc    15660

ggacctggct ggcgggagct gtccagtttg tgccggagcc ggttgcggta tttccgttaa    15720

tagagatagt tccggtgcta taaatcataa caactcctaa atttagacaa catgaagccc    15780

ggagaggtat ataaccctca ccagaaataa tttctgaatt ggtttttaat acatgttggg    15840

caacgccagt gttggcatag ctatagttgt atcaaatgcc attgaccacc cacccaaata    15900

ataattgccg actactttat tcctttctgc tctgacattc ccacctgtca ttacaattcc    15960

tttataccta atatttccgt aaccaccaac gtgtcgacag ttagccccgg tataaacaat    16020

ctggcaaaat tcatcaccaa tattcaggtt cgcattggcg atatttattg tcccatcaaa    16080

aatgaatggc ttcgtgcaag taagaagacg tttgcgttga cgattggttt attcaatcca    16140

tcaactaaaa tatcatgtaa acgaattgcc ataacatttc ccactttatt ttacttactc    16200

aacacaacaa gtatattaaa attgaacctt gtcaacaaca caaaggagtc ccaatgaaac    16260

tcgctctaat tatgctgcca ttatgtctgt ccctcactgc atgtggtaat ggtttaaata    16320

ccggtaaacc aaattccggt gtcattccaa aacctttgga tcgagatggt aacggttctt    16380

taatttatga taccgaaaac cttccaatga cggggcagtg gtgtcacgag attgatcacg    16440

aataccgacg aatcggtagc ccttctaact gtgttataga ctactaaata ttaacccctc    16500

aaaagagggg ttaatatttt aacctgtgaa tgaaccagat ccgtgtgata ctatgatagt    16560

aggcgaagaa attgacgcac ccctgttatt ttgagcggac actttaatac gcactgttac    16620

gtttggacct gttacaaccg cagaatgcat gataagtctc tccatgtctt gcacggatga    16680

accactctca ttgccgttaa tgtcgattgt tcctgcacca ttacctttaa cgtttgctat    16740

aacacagacg tgtcttgcgt gcccagaact ggatgaatca ttataagtca ttaccttttc    16800

taaatatccg tcactagacc gactcacatt cgtccctgtg tgcatatttg caatgtcccc    16860

gataaaactt tgggcttcca cagtcccttt gaatttaccg cttgttgctt ggatctcacc    16920

agtaaagcta ccgccactag catatactac acctctgacg gtcacattgt tgaattcagc    16980

atctccagct ttattcaact tccaaccagc agaaccagct gcatagttgt tggactggat    17040

atagttaccg atttttgcgt tctcaatggt gccgtcctgg atgaagctgg cccggatgaa    17100

tgtctgcccg ttctggatca cgaacggcaa agctacgcta tttccggctg ccgtggtgac    17160

ggcgaagcgg tcagccagga agataacctg cgactgcatg ccggatggcg tattctccac    17220

gccgataccc atccccgcgg cgtaatactg cccgttgctg gagacaccaa ccttgatgtt    17280

gtacatcgcg ctgagttcgc cattaacgtt ggctatagcc tgagcgttag tggtgatggc    17340

ggaggtatgc ccgttcacgg tcgccgtgat gccgtttatc tgcgtggcgg tggcctgctg    17400

atagtcggag agcgtctgat tcaggctgtt gatggatgcc ttgttgccgt tgacgtccgt    17460

ctgcaggctc agcaatgaac gtgctgtggc ttccttctca ctgacgatca cctcgtcgag    17520

acggtccaga ttcgcgctgt tgccggcgac cgatgcagaa agggttttac gcgtggccac    17580

ctgagcgagg ttggcctgga ttatcgcaat tgcagagttc ttcaccccgc ccgtcatgcc    17640

gtccatagaa acgctgatgt tgtcgattcg ctggcccagg gcggtatcag ccgtcgcaac    17700

ggtctgctca agctgactga gtgaagacga aacattcccg accgtgctgg aaagctcatt    17760

aacgctggtc tgaaccttcc cgacgtcctg ggcatttttg gcgatatctt tcgcttgctg    17820

ctccagttcg tcgttggcct gtttgatatc gttagccatg ccagcaattt tttcgttgct    17880

gtccaccgcg ttctcgatca ggtctttgaa cgtttccgac tctttcatat cctccagaat    17940

gtcattagtt atttcgctga catctatcga ggacgtgccc atgatccagt cggtccagtc    18000

cccggcgtta ccgatacggt caatcaggcg cgcgcggtac cactggcgaa cgccggcagg    18060

catggggcca tgctgataat ctgcagccgg gtacggcacc aggaccagca gttcaggatt    18120

ggcgtagtcg gcagttgtgg cgcgctgaat ctctgtatag gccgtgtcgc ctgagccatc    18180

cggaaatttc caggtcaggt cgatatgcca gaccacatct tcggtcgcca ggaagttgag    18240

cggagtaccc ggttttcccg ttttaccgga gagataagtt gtttcaccgt atccccatgg    18300

tgacgacgta tcctgcgcat tcagcgcccg tacgcgcacg tcatagctgc ccgaataaat    18360

gccctgaacc gagaaaccct gcgcgctggt aaccggaacg tttatccagt ccccgttgtc    18420

cttacgccac tgggcaacat accggattgc gccctctacc ttatcccatg acacgtccag    18480

gcttgctaca gtcagcccct gagacacatg atcgctctca gtcaccacga tattcttcgg    18540

agcagacagg acgcttatcg gcgtgacggt gatcggggga gactcgaccc gaacgccgtc    18600

atcgatgtaa cgatatttgt ttggatcgtg ctgaacggcc gtaatagtga aaccgcctgt    18660

actgtcgtcg ttagccgcga ttgaggtgac cctgaagtac tgtattgcga ggttatcact    18720

gtctatcgcc caaacagcgc ccgccacagg aacctgactg aatgccgtag ccaccgtcac    18780

cgttttttta tcggcgctca ccgcgctgat tgtccgcgtc tgggcttttc cgtcgggaag    18840

gttaaccacc agccggtctt tcgccgcgta gtctatttct cgatcgaggg taatttggcg    18900

gccgttggcc gcgcttatac ggcccccgtt ctccttacca gagcggaaag gatcggcgac    18960

accgataatt tcagcgggca aagggatata accgtccagc cccacgccaa acgatacggt    19020

cccgtctttg gcattggaga gcaataccca gcgaccgcgt cggtgcgctt cactttgcga    19080

ggtgcagccg attgcggtca gggacgtctg ccggacgtcg taacgttcta caagcgccga    19140

atcgtaaacc ccctcaacgg tatcgctgta atggttctgc ggatcggacc aggacaccag    19200

gcaggagctg tagcgattct tgtatgagcc gcccgcataa gtaaacagcc catcgataac    19260

gtttgagacg ttataaaccc agtcaacatc gtcctgcggg acgtctgcct ggacataaat    19320

ctgatcgttt ccccagaacg ttattccacg aaataccgcg gcgagatcgt taagtacctg    19380

ccaggcgtcc tcctggctct gaatgaaaac gttgcaggtg aaacgcggtt cggtgccacc    19440

ggccccgtcg gaaaccattt cgtcacagta ctgggcgatt gaatacagcg cccacttatc    19500

caccatggac gcatccacgc gcgtgcccat gccgtaaatt tcatccagaa ccagatcgta    19560

aaagatccag gcagggttat tggaccatgc cattttgaac ccgccggacc atgaaccaga    19620

ataggttcgg gttttcggat cgtaattatc cggaacctta atcagcttgc cttttatctt    19680

acaggtcact ttcggcgcgc tgccgttgaa ttggctgctg tccacttcga catacaggag    19740

cgctgttaaa ggataacgaa gcttgctgtc gatgacttcc gcatacgaaa acaccttgaa    19800

ggcgttaacc agtttcgaat ttgatccgct ggcatcagcc gtaatacgcc tgaccctgac    19860

agaccagccg gacgtggatt ttggcagatc gatacggtgg tcacgctgat attccgtcgt    19920

ggtctttccg tcaaacttgc cgtttacaac cgttttccag gcgccgccgt ccgttgataa    19980

atcgatcgca tactcggtga ccgtgcccac catatcgcca ttatctttat agagatactg    20040

gaccggaagg ctgagcttga tacggatggc atccagggaa aggtttgtaa actggcgcgt    20100

ccagggcgcg gtggtggtga cagttgtgcc cacggccagc tcgttgtcga cctggggcat    20160

cccggcaata taggtctggt cctgtgtgcc cttgcggaac tcccatttca cgccgctgaa    20220

gttgtattcc ccgctgtcgt ttgccagcgg cgtatcgttg agaaaaatgt tctgagcggt    20280

caggtcgccc tgtatttccc cctcagaaac ggcaatgagc atttttaatt ttgcgaccga    20340

cagcagatcg tcaggctgct caaccggagt atgtgaactg ccacctcccc ctttggcacc    20400

ctgcaggatg gtttcttgtt taagaagctg cattttttca cccataaaaa aaggtgccga    20460

agcaccttta agttagtggc cgctggccta ctgctgatcg ctcgagtaca taccggcgct    20520

gactatcgct ccccctgcct cagtcagacc gtaggccagg gggacaggat gccccatagc    20580

gacggtattg accggcgccc cgaaggcgta gttaggcgtg ttgtccgtgc tggaggattt    20640

acccgcgccg aaggatggct ggggcgtgag catctggaca acgcccccca gcatcatcga    20700

cactccgacc cctgtcagaa ttgacgtggc gctgatagct gttgcactca tcgccgcgcc    20760

ccaggctgcc atgctcgcac cagcggtaaa gaatgcagcg accagcgcaa cagccccgac    20820

aactatctgc aggacgcccg aacttttggc cccctcataa acgggcacga tccggtacac    20880

gcttccaccg cgggtcatat caaactcttc cagcccgata ttgttgccac cgttaaaaaa    20940

ggcgaaacgg atccccttca tatgagcttc agacatatat tttttgaatc cgggaacctg    21000

tgaacacatg gccctgagca tctcgcgcag gtcggcaaca tcaaactgaa cgcgtttacc    21060

gaattttttt gccattttac cttcgagaat aagcgtctta accatgcatt ctgtccttat    21120

gcctgaccac ccggaccgtt ctgtcgcgat aatattttcc ataaggcgtt cgcgaagaaa    21180

ggtgcccgaa aagatgatgg agaatgatgt tatcacccac atataccgcg gcgtgattag    21240

tcaccgatgc ctgcacactc atcatgatga tatctccggg ctgcattgca ccggcggcaa    21300

tctcaacgaa tccctcacgc tcccagttgt cgtcgtagag acgctccttg ccgctctccc    21360

accattcgta aggtactgaa taattgccga gaacaatgcc gtattcgcgc agataaaatt    21420

cacggataag cgaccagcag tcggcgtaac ccagcaccca ctgccgcccg gcataatccc    21480

ggtcttcacg cggggaaatc gtacaaaaat ccccgtccgg ccaggacatg atcccccact    21540

caatccccga ccagtcgcac tggatccggt ccagctctga gggcaccagc cgaaccacat    21600

ccggatggga atgaatgagc atgatgatct caccgcgcgc gcgggcagcg agctggtctt    21660

ccggggagag cgtgaatgtc tcctcgggtt tatcggcaat gttgcggcag ggaataaaga    21720

tttgttgctg gcctgactga acaatcaggc cgcaggcttc tttggggtat tcagcagcga    21780

cgtgctgacg gatagcatcc agcaattttt cacgcatttt tatttcccct gcaggtttgc    21840

agccggaaaa ccgccgaacg gcagcggcgc atccgggccg tgacgatcct gacaatcctg    21900

ccggcggccg ccacaaacat ctttcgacgg gtcatcggtc ggtgtaccgt ctttggtaaa    21960

gtatttcgtg ccgttgtaat cgcatccggt cccgcttcgg taccagcccc gcatacacca    22020

ggtgcagaca ggcgtaatct gccgtgtcgg cagctgcagg ctctgaatat cgaaaggaga    22080

acacagctcg aaatcaacct gtacccgcgt ctctgcggtt ttagcattga cgtaaaagag    22140

ctgtaagcgc tcatcggccg ggctggcacc cggattaccg tttttccagt tggcggcatc    22200

gagatacttc gaaagcgtgg tatggatttt gaccttagcc ctgaccatat cgtcatattc    22260

aagacacagc gcggtgacat agtttccgac gttcccgacg gacagcgtgg gcgttggctg    22320

ggaacctgta ctcgataact ccatcccctt aagttcgtag ggatggggat cgtactggtt    22380

tccctgccag ataatggcgg gcagattttc tgcggcgaag gctgcccacc cctcttcctg    22440

aatattgtgc gcatgaaaac gcagcacctg atccataccg aattcagtgc cgtcgatctc    22500

aatcagctga ataacgctgc cgggctcaag ctgttgtatg tctgccgtaa aactcatact    22560

ccccccataa aaaaaagccg cccggaggca gctttcagtg tttttcgaga aaatcagggc    22620

gcgaacgcct gttcaaaagt gaaggccaca gtggcttttt tcccggtagg gaaagaaacg    22680

ctgaacgaat cggccttcat tctgaacagc tttttttcac cccatggagt ggtccaccag    22740

aacgatttag taacgtgaga catcaggaaa gcgcgcagcg cagccgcctc ctgtctggtg    22800

cccgtccagt ccaggttcca cgtttcctgt ttgtcgttga tccccatccc cgctatctgt    22860

ttgtagccat ccccgaactg ggcctgcagc gttcgggctg tttcagtgcc ctgcgctgtt    22920

tttcgcgtgc gccaggtaaa cgtgtccgtc actgtgtcct cctcgaataa agcacgccgc    22980

ccgcggacat ttcttttttc agtcgctcgg tgattgtctg ctgaacaatc gcctgcagct    23040

gtttcgccgt ccccgtggcg ttcgcctgat ttatgcttcc gtcactcccc tgctggctga    23100

tgctgactgg ggcataaaca ctgatcccgc ccatgccagc accggctgcg ttcccgccgc    23160

cgaccagacc acccgaggca tacccgcgca tcaggcgata gagattagcc acgccgatgc    23220

ggctggttga ttctttggtg aagacgaatt ccccgcggtg aacgataccg gctggctcgt    23280

acttgccgcc gtgcccggta aaaccgccca cgtcaaaacc ctgtggccgg tatgacggga    23340

ccgcgaatga ctgaccggca gaggaggttt tcgccccgcc gctaacccag cccattgcac    23400

tctggatggt gtaagccacc agcagctggt tgataacgga cacaatcatt ttaaggatcg    23460

agctggtgaa ttccctgaag ctcgccttcc cggttgtcgt caggctggta agctggcccg    23520

ccaacccgct gaacgtagcc tgagaaatct gctgaacgga gctgaaaacg tttgtcgctg    23580

aatcctgata ttcggcccaa ccctgtttcg caccggccag ccagtttgca cgcagggcat    23640

cttcagcttc gaacgtcgcc ctttgctctt ccagaacctt ttgctgcgcc tgagggttgt    23700

acgaatagct ttcgctgaga cgctgcagcg tagtttgtcg cccggcttcc cgggtggata    23760

acccctcaga ctgagcctgc aggcccgccc tggcggcttt ttgctgctgc tcaaacttca    23820

cggcctgatc ggccagctgg ttgagctttt gctggctggc aaccttatcg cccaggtcgg    23880

ccagctgccg cttgtactcg agcgtttctt ctttgtgcgc cagcagggat ttttcctgcg    23940

ccgtaagctg acgacgccca gcggcctcct gcagaacggt gaactgattt tcagtttgcc    24000

agagatcctg acgctgttta cttatgacgt cgttcacgct ggtatgctgc tcaagcgttt    24060

taagctgggc ctgaagggtg agaagttcgg cctgcgcctt ttcctcggct ttgtccccgg    24120

cgggcgttga gtagcttttg cctttcggtg tttttggatc cttccactgc ttttcaatcc    24180

cggcgcgggc cgcggcaatg tccttttcag tccacagcgt ggcgacaccg tctttcgcat    24240

cctggcggtt tttctcaata agctgactga gctttttctc tgctgaagcc cgcttttctg    24300

ccgccgtcgc gccggactcc accagctggt taaactgctg ctggctgcgg attgcctgag    24360

cctgctggtc cgttcgcatt ttttcccgcg cggctgccag cccttcctgg gcgtattgct    24420

gatcggcaag atcgtaagcc tgctttttca gctccacctg ctggcgcgcg tttctcagcc    24480

tttccgcatc cgctttctgc agaacgttgt taccggcata atccgggtcg accttaagat    24540

tgctggacag cgcgcggtac tctttctctg ctgcctgcca ctcagcaaaa gagtcctggc    24600

gcttcatcgc ggtgtcagga ttacgcccga cgcccagcat cgcatcccac gcaccggagg    24660

cggcattctt cacccagttc caggcttttt cgagggatcc gagattatcc tcgaccgcac    24720

cggcgcgctg aatgaccgcg tcggaatatg cccgcatggc cagctcggca gccttctgag    24780

aatcccccag cgcctgagca gaagctatct gttcatactg ggtggctgtc agaaaatgaa    24840

gggaatcgtt gagcgtcgcg accgcgttaa ccggatcatc cttcaggcgt ttaaactgat    24900

ttatggtttc gtcaacggcc tgcccggtag cctgctgcag cctggcggca acattgctga    24960

ccatgctgac gtcattaccg ctgaacgcgc cgctgccaac gacctgcgcc agcacgcctg    25020

cagcggcatg ctgagtgatg ccattacctg ccagcgagcg cgccagcgcc tgcagctgcc    25080

ctgacgtttt ccccgcgtag ttcccggtca ggatcagctg cctgttaaat tcctcagact    25140

ctttgctgcc gtcgtaccag gccttaccca acccgaatac cgccgcggca atccctccga    25200

ccatgctggc gatcccaaga ccgcgcagtg acagaagctg gtctatccac cctgcccggt    25260

tagccagcgt gatcccggag ccgcgcagcg cgccgaagtt accgcgcatg acctcgccga    25320

tcagtattcc cagttcctgc cgggcggcgg cactttgcag ccccagaccg tgcgtggcga    25380

ctttggcagc ttcgagcttg cggatataga cttcagccgc atcgctggca ccgacctgcg    25440

ccgccttcat gcgcagtagc tcggtaccgg agagcttttg ctctgcaacc tgttgcttca    25500

gctggctgag gaatcgcgtg cgcgctgcgg ccgatttttc ctccacgatc tgcagttctt    25560

tttgacgggc cgtggtgcgg gaaataaggg cgagataatc ctgctgggtt atgttgccct    25620

gtgccctcgc tgcgcgaaag cgcgcctgca cgttcgcaag cgactgtgtt tcaccattga    25680

gctggcgtac gccgtcgatc tggcggaaaa atgatgccgc aagttcatcc tgtcgacggg    25740

caagcgcagc ggcctgcccg tcattctcac gcatgcgctg attaagctcg gtcacgcggc    25800

ggtgagtttc atcaacggac tttgaaacgt tctgccagtc tttggtaagc ccttccgttg    25860

cggccgactg gcgggatttc atatctgcgg cagccgccgc gccagcgtca cccacggttt    25920

taaacgcagc cgcctgccgc tctgaagcgc gctgcattcg cgtctggact ttttcagagt    25980

cctcagccat cccggttagc tggcccttta tgcgggcaac ctgctcacta aacgtggcgc    26040

tgtcgacgtc aaggttgatg accagatcgc taatctgctg ggccatatcg gatacctcct    26100

gttatcccct cagctgcggc catcagcgca tcatcatccg gctcgtcatc gctgatgacg    26160

ataccggaag gagaaagcag gctgaaatgt gcgggggtaa gttccgggtc gcggaagaaa    26220

agagtggaga tggaataaag cagctctgag aaatgcgcat cgagctgagc gtcctgaaaa    26280

taatgctccc ggtagaactg gtgccagtcg cccagctcag tggaagtcat tccagccagc    26340

atggcgcgcc agtcgggtcg cccgaactcg cgcgccagat tcaggacaaa cttcagctcg    26400

ctggcaaggg cttttccgcc gcaacgggtt ctgcgctttc ggcctccgct ggggcatccg    26460

gatcggcagc tttgtcatcc tcaaccggaa cgagcatgcc ggagagcagc tttatttcca    26520

tttctgcttt accgatcgcc tccggcggcc agccgctaag cacctgctgg taaagcgtct    26580

ccacatccgt gccagccgga tcgttatgcc acaaagacat cgcaatcaaa cgcgcaccgc    26640

agcgaatatt tgagccaatc agcctggccg tcatttcctg atcgctgatg ccgtcgctgt    26700

cagcgctgac ggccttttcc tctgcggcca taaacgtgat gtactcaata cgctgaagcg    26760

ccgacagctc gaagatggtc agtgattctt tttgccaggt gaacttctct tttttcagaa    26820

acatgcgtcc ttccttacgc tgcagttacg gtaactttgc agaccgcaac gaaattaccg    26880

tcgctggtca taacaataac gtcagcggtg cctgccgcca cgccggtgac ggtgatcgca    26940

ttaccgctaa cggtgaccgt tgcttttgcc ccgtctgagg ttgccacacg gaacgaggta    27000

tctgaggcac tggctgggtt aaccgtcaca ttgagcgttg tggttgcgcc gacggccacg    27060

cttgccgtgg ctttatcgag cgtaacgcct gtcacgggga tattcggggt cccgctttct    27120

tctgccagtt ccggcttgcc ggtattggta attttcgctg tacgggttat gacctctttt    27180

gccggaatgg ctttacccag gctgctgcac cagccgcgga aaacgtcgac ggtaccgttc    27240

gggtatttga ttttgtaata gcgtactgag ccatcaataa accatgcgac aaggtctttt    27300

tgcccttctt cgcccggctt ccaggcgagg gtgaacgagg tatcgccagc agattttgcc    27360

ccctgggccg tcgcgttcca gtcggcatcc tcgtcgtcga ggtaagtgtc gtcatacgat    27420

tcggcggtca tttcgcccgg cgtcagctct ttaattttcg ccaggcggtt ccagtcgata    27480

tccgagagtg ggttagcgaa agcgttgccc gttccggtgt aaagccagag ggtggtaccg    27540

gcacctttca caggggccag cgggtttgga gtaggcataa gtacctctta aattgaatag    27600

gtgattaagt acgtgaaatc gactgaaccc caggtggcca tttcatcatc ccgctgatag    27660

tcataaccct gcggggtgaa cgtctcgacc agttcggtca gacctgggat gaaggccatt    27720

gccggataca ctttctcttc catccaggaa tcaagcgcgc tgtcggggct ggaggcttta    27780

agaaatacct cgatgtgaac aaccgcctgc cacgaatctt cgtcaagcga ttacacgtct    27840

tgagcgattg tgtaggctgg agctgcttcg aagttcctat actttctaga gaataggaac    27900

ttcggaatag gaactaagga ggatattcat atggaccatg gctaattccc atgtcagtcc    27960

agtgattctg aataggcgat aagtccggta taaccgggga taatctcacc attatcagct    28020

tcaaattcag gaattgtgcc ggtggtgatg gtgtattgag gctggccatc ttccttcgcg    28080

aaggctgcca ggtcttcaat ctgcttagct gtaagaacta ctgtcatgct cattcctcag    28140

ttgtaaaaaa gccccgcgag tgcgaggcga tttgattgaa ttctcggctc ttatctcagc    28200

gcagcccctt actgcgtgcc ggttgctcgg tgatgagcat cagcgatgag acattaaagc    28260

cgaccgaagg ccagcggcgt tcctcatgtt gccgacagag ccatatcgac aagaggacga    28320

aaactagcag catgaatcgc ctattggtta ttcgacagtc gcactgattc gtaaatccgc    28380

tcacacgtca ttcctgcccg gtagctttcg tcagatcgtc cagcataata tcgagctgct    28440

tctgcaaggc ttccgagcat gtcggcaagc attgctgcgt tggctccggc tgttttgctt    28500

ctgacggaag tggcgagatc tgcggtgtgc tttgcggcgt ccatgtgggt agcgagtttt    28560

gttgcttcgg cgcgcagctg cttaacagtg gtagccaggc cagcagaagt aacggcagcg    28620

ctcgctgctt gagcttgagc atctttaacg gcctcatccc gggcgattgt tcgcccttgt    28680

tcaatcatac gagctgcggt ctgtgcattc gcttcctgtg aagattccgc gctatcccgg    28740

tcagcccact ttattttcca gctgcggttc gtccactcac tgccagcgag aaacgaacct    28800

accaacgcaa caatcacaat gatgcagatg ccacccggct tcactggtct atcccccagc    28860

acgtcagtgc gctttcctgg tcccgccgtt ctacctgccc ataacatcca tccttctggc    28920

ccttggtcag gcggcaatcg cggccaccgt ctttaatcca ccagcggata gcttcacagg    28980

ctcctttcgt atcgccagca ttaattcgct tatagaacgt agacgggaaa cattttccgg    29040

ggccgatgtt atatgggcag aaagaagcga tacccgcttt ctgtggttcg gtcagtggta    29100

ctttgatatt tcggtcaacc cacgccagcg ccttgtcgcg ttcaatggcg tttacctggg    29160

cgcatttctc agctgacagc ttcatgccct gtactactgg cttgccatca accattgttg    29220

caccacggca aatggtccag agtccgccgc cgtcgcgata tgctgtcaag ctgttaccct    29280

ctttctcatc cagaaactga tcgagaatca cgggtgcgga agccccggca agaatcaaac    29340

caacgaccgc tgcgctcaat ttattcttca gctttagaga catagccatt gcgccgatcc    29400

tcccgttctt tccagcggaa ataccagttc actgcacagg tgattaccgt gcatgcgata    29460

ccgacaataa ttgcccagtc gctcaggctt aaccctgcaa ttctgtcggc caacatccag    29520

gacacctctt ttgctgtttt agctgtttcg gcatatgcct tcgctgatac accgcagccg    29580

gcaagcgtgg ttcctgatcc atatgaaagt ctgctgtaaa tggtgctcat tctggtcata    29640

gcctcacctc cgatagttcg gatggcgctg tgtgtgattg aaggggatca ggcaaccggg    29700

ctcttatgtt caagtaaaaa ttaaggatga ttcccggtgc ctgaagatgg tgatcaccac    29760

agcaacgggg gagcgtggtg atcgttatga ttttttcagt ttttccacct cttcggtggt    29820

ctgtataaac ctgtctgcct ccagttctac gccgatcgcc cgacggccaa gttctattgc    29880

agctttcaca gttgaaccag agcccataaa gaaatcggca acgatatccc ccggtctgct    29940

gctggcgcta atgatctgtt tcagcatgtc ggcaggtttt tcgcatggat gtttgcctgg    30000

ataaaactga acaggcttat gtgtccatac gtcggtataa ggaacaagag cggaaacaga    30060

gaagcagcgc cgaaggattt tgtattcctc cagcaattct gaatacttgc ggtttaatga    30120

ctggtaggta gccaccagct ggtggtgagg atgttcaagc ttttgctgaa tatgtttatc    30180

gatggcgatc cgcgtgaaca gttcctgcaa ttttcgatag tccacttcat tcggtagttg    30240

ccattggctt gcaccaaacc agtgtgacgc catgtttttc tttccggttg cctcagctat    30300

ttctttcgag ctgacaccca gtgattcacg ggcattacgg aagtaatcaa tcagcggcgt    30360

cataatgtgc tgctttagct ctgtgctttt cctttcgtaa acatcctctt tacctgtata    30420

cggtccaaga tagtgctcag caaacaaaat ccgttccgta gatggaaagt acgcacgcag    30480

gctttcttta ttacatccat tccagcggcc cgatggtttt gcccaaatga tgtgattcaa    30540

aacgttgaat cgggcgcgca tcataatctc tatatctgag gccagtcggt gaccgcaaaa    30600

caggtagatg ctgccagcag gtttaagaac gcgagcatac tcagccaggc agctatcaag    30660

ccagcgtaag tagtcctcgt cccccttcca ttggttgtcc cagccgttgg gcttcacttt    30720

gaagtacgga ggatccgtaa ctataagatc aatagagtta tccgggaggg tggcgacgta    30780

atgcagacta tcagcgttga ttaactcaac actgtttatt tttacagtat ttttcataga    30840

tcagtaagcg taactctgat aggctcacgt tgcttttgcg ctaaagcagt gggccttggt    30900

tagcttgtga cctgaaagca tgagctgatg gctggccggg tgcgctaaca cccaccagcc    30960

gcccatttcc acagcagaaa acccccatta ctggaggcgt ttataacatc cgaactggta    31020

atcagataac cccgccatca ccagctgcgt aagtatgagc tggcaacgtt cgtggctgag    31080

gtgggtattc tgtgcaatct ccccagccgt tgctggttta tcgcttaatt cattgaaaac    31140

agcctttgcc gtttctgtca tatcttcctg atttagcatg tcttttacct aaaattagtt    31200

gcgtgacata cagataactc tggttggtga taccagcaag agaagaattt gattctgcaa    31260

ccaacaaggc ctttaggcat caggcaggaa tgagatgcaa taaaaaaacc acccgaaggt    31320

ggtcttatat gaatctttaa cgcggactta gcaaatattc cacatcatcg tactaccgtt    31380

atggttttcg ataatttttg cggctgggct agtaccaaaa gagtgcatat agcaatgatg    31440

aatagtaagg accagatcct gcaacgtttg gtcactctct agctccatga tatttaaacc    31500

aatattttga gctttgtcca aatgaatatg tctggcatgt gcatacgttg cttggtggtt    31560

gtttaactca tcacatatac gcttagcctt agcttcagcg tcagcctgac ctgcgaacat    31620

accagtacaa agccatttct ggacaatttc gttcgcccag agaattgctt tttcacactc    31680

gccaatcaac gttggattta gtttttggaa cgtaaattgc caccattgca gtgcagcagg    31740

gttggcaaaa atttccgctt ttgctctctc atactcctca ataattgcat gagatgataa    31800

cccattaaac tgtggatcaa ttggccccaa gttcgactgt ttacctaaaa cgatctgctc    31860

agcacaacaa gcaagcattg tgccacaact cattgaaatc ataggtacaa tcgctcggat    31920

attggttccg aactttgaac gaagataatg accaattgat tctagagctg cgatatcgcc    31980

tccaggagta tggagtaaga tatccaatcc cagactcgta tctaacccat tgatagcaga    32040

cataagacca tttttatcat catctgacat ctggatcaga tgttgaaacc caggcccccc    32100

tttttgaagg aagcctgagt aataagaaat tacatttcgg ccagtatgtt tcgataaatc    32160

acgtaagtac ttgtggcgaa cctcatccgc tggtgtacgt tgagcgatag tacccatctc    32220

acccaatacg tctatccaat ttggcatgtt atcaatttat cagtatgagt acagttggtg    32280

agattgctga ccgttctgct cagtagtatt tggtgttact gtgctgtatg aatagagcac    32340

accacttctc acattcagat cgttttgctg agcgagaaca cgcatagcaa aatgctgtac    32400

ggattcgcct ttttgaaact cttggggttg tatgcccatt ttttcgtaaa attcagcagc    32460

gctcatgata tgtccctcgt ttttttctac atctatgcaa ttccaggagc catcaacaca    32520

agatgtagta gttagcagtc gtcaaataca cgaaaagcct caagatgagg cttaaaaaga    32580

ttctttttga taaagattta gccaaactat agcggtcaaa atgcagattt gacaagtata    32640

aaaagcactt aaagcctata aataggcagt ttttgagaat taaagcatct ttaatgaggt    32700

tgaacaaaat gcagtcttga cgctgaacag gactttactg gaacgtagag ctaaatggtt    32760

cgatttcatg aaccagttac aaaaaaaccc gctcatcggc gggtttataa aactttggca    32820

acatatcaaa tatgcttcaa atatggctta ttttgttgca ttttgcaagc gtgtttgaag    32880

gagatggtga aatttacttc acatttctgc cactttgagg gcttcttctt cctcatagta    32940

ttcaagagcc atggccaacg cagattcatc aagctgggta aaagcggcct ttaacccagc    33000

ccagtgccct gaatagacac gcaaccatgt cgaacggtca acgctaacca tgcgggccaa    33060

cgctgcacca gcatagtctt tataggtttc attatttctg gttgcggcaa tttcctgccc    33120

tgccagccat accaggccta tcagtttctt tactacgcgc tcctgaaggg agttatcacc    33180

caggcatttc tgataagttt tccagacgta ttcacacatc atcacctggt gcttatagct    33240

aaggtcaaaa ccgtagcagt accgcaacca ggcctgctgg tatccactaa gcgcggacac    33300

tgccctacgc cacggcgcgg actcaaattc cgcatctttt atcggcggca ttggcctgcg    33360

gcggctgcgt gtttccagca catacagtgg cgcggaaagt gagttaacaa agcgtggccc    33420

cttctctcct tcgagttcga cgagatgaat tccacggcga ggggtggcat ttttgtctgc    33480

tggtgggtgt tcactgaaag cctcaagctg cccttttgtt cccccagaca ggtcaggtag    33540

cgcgcggcgc aattctattc ttacaaaatt caggtcttgt tgattcatgc ttctttgcgc    33600

tccatacact taagctttcg caattacgcc gatcgccagc gcccgatcca taaaacgcag    33660

tagcagctca agctgcgtac catgcttctg ctcgaatgcc ggtacatcgg cgtgtaactc    33720

gtcgtggcac tctctgcaca gagggatcac gaagagatca tgggcttttg ttgctgtccc    33780

ccccataccg tgccctacga tatggtgcgg atcatctgct ggccgtcggc aacactcaca    33840

gggttgtgtt ttaacccagc gggtgtacgt ctcatttatc cagcggcgtc gctttggcct    33900

gagcatgaaa gattctggag actccggatc aacagagagc gtgaggatct tcttcgcctt    33960

ctcctgcacg aggctggttg cagaagcgga aggcacaatg tcgctttccc tcatgaccga    34020

gcggatctta tcatccggaa ggcgtagccc cttgtgcgca acgctttccg gaataacatc    34080

agccaggtcg tttctgacca tccaccagca cagttccgga agcgtcagga tatgcgactc    34140

gggaaaacca gaatcacgcc gaatgacttc cagaatccag gataccaggt ttcctgccgc    34200

tatacctgca agctgttcgg tatgctgccc cgacaaagtg tgatcgcaat gccagcacag    34260

gcgaatactt cctggtgggt gccgcattgt tgtgaagttc ttgtcgtgcc acgatgaatg    34320

tggccactgg cattcaaacc gattactcaa ccattgctca agggaaggaa gcccaccagc    34380

acgctgaata acccgatcat tctcgaagac ctgccgcatt accggatcat cagccagcgg    34440

ctgaatggcg gcgggaacag ctcctgtact gaatgacgcc atttcttctg gttcaggctc    34500

aagcagaacg cgaccgcgca taaagaggtg catcagttcc gcgccgggac gaaacaacac    34560

aatccccata cgatgggcga tctcgggggt aagcagagct ctcacgcgac ctgccccctg    34620

gcaatgtgtt ctgcccacag tccaccaatc cagcgcacgc ctttcgccgt gaaacgtgcc    34680

tggctgaatg catgatttga ggttacggat gtgccggttt tcacttcaaa acggcccgca    34740

tcaatatgct gatgccgtgg ggtcatcgtt ccgccaagac gatacatgat gtcgttctca    34800

aggaggaata accgcagatc gggctctttg gccttaagca gttttgccac ctggcggaat    34860

gacattgacc cactggctgt acagtaccga tcaacaaacg ctaccttcgg cgccgcggca    34920

gccagttcgt tagtcaactg ctgtttttgt tctgcaaggt cagctgcaag acgtagggct    34980

tcagagaatg attgaggaat cgtctgctgc tgtgcctgct caagctcctg ccagcgatca    35040

accagacgcg cggtaaactc cggcgacagc tgcgcgacaa cgatataact gtcccgcttc    35100

cctatcagat aaaccgatac cgactgattg aggtgatttt taacttcccc cattgggggg    35160

agttcaataa caccgcgctc tgccaggcgt tcaatggacc gtttaacatg gtcatgtctt    35220

gattccacca gctcagcaat atcgctgctg gacatggtta acgctgttgt tgctaactgg    35280

ctcatacttt tctccatatc aggcggctgc acccgccggt tcatatctgc tgattgttat    35340

ctctacccga cctttcggca caacgggtcc ccattccacc agcatgcgct taatctggct    35400

gtcgtcttcc cagacacccg catgcgtcag cgcgtcaaac agggctttgt tgtaattatc    35460

gatatcccgg cggcgcgcat ccggcgggta cagagtgatt tctaccgctg ccagttcagt    35520

cgatggcttc gggagacgtc gtaattgctc aatgatcgcc acgcaggcag cgctctggta    35580

tttacggcca gcggcgctaa tgaggtgacg accggccagc ggccccttgt taggggcgcg    35640

ccagtaagtg ttcacgctcg gaggaaaagg caggatcagt ttcacgcggc ctctccccgc    35700

atattgcgaa caagttcaga agcagcagta atgatttcgc tggtggcagt ccgctccagc    35760

cagagttgat tgatattggc tttcagcttg tgttgcagtg actcatccag catgtcagca    35820

ccatccacct ggtcgaatac aattctaacc tccagcggcc agatacggga ctcgggaagc    35880

ggatccgata ctggtttagc tttctcacga atgtgcatgc ggatctggcg aatattggac    35940

caactggaaa catccaggct tcccatggct gcaatgaagt cagtgctgtt catgccatat    36000

tcaccggatg cttcaagggc aacagtgcga atacgttccg acatatccag gcgcacagca    36060

gcgtcatcga attcaatcga caacagccac tcatccacac cgaacaaaat actctcacga    36120

ataagcagct tcgctttgtc gatcgttaaa ggtgatacct gagtgaattc cggtgcttcg    36180

acagaatccg ccgcccaggt atgcccaaac ttcgattcac tgaatgtgta ttcttcttta    36240

tcgccaaacg cagctctaac gcatgcccac gcctcgacac cgctgatagc aaaaatatct    36300

ttctgggtga gtggcaactc tgcttctggc ttatcagctg caggaggtgt ggcagttaca    36360

ggttgagact tgctggcagc aaattgtgcc aaagccataa acgcccgccc ttttgcctcc    36420

agttctgtgc ggttgatata gctgaaccgc tcgccacgcc atgacttatc gaatacagct    36480

atggcaccgg caaaaaacgc gctggtgggt ttctgttttt cgtcagcagg tacaaaccac    36540

acaggcagat cgaacccaat gcgcccgcga atgaatacaa tgtgatcggc atcttccggc    36600

caccacgttt cactcggcgc ggcttttatc aggaatacat agcgaccgcc cttctcgcgc    36660

tgggctgctg cgtagttcat gatgtgcgtc atgccggtga tcgcctgctt ctcgtggtac    36720

tgcgaacggc tatacggtgg gttgccatag ccagcgccac ccagttcagc cagacgttca    36780

gaccagtcct gcgtcagcgc gttatcttcg gcggtgtacc atgccgggca tttcgcgttg    36840

tcgtcgtcag caaacaaatc cagaactaat ggaccaaata gcgcgttgat cccccaaaaa    36900

agcagatccg gtgtccgcca ctgatcgcca acctctttca attcgtgagc tggtttgcta    36960

cgcagtgccg ccagcgcctg gcaatattta ttggtcatca tgaacggaac cccgaatttt    37020

ctggcagtga gtaatcaaca ctctggaagt ttgcgcggct ggctgagtta gtctcccatt    37080

tgccgttaac gcgttcaggc cggccagcac tggaccattt ggtcgcgctt tgcaggtaac    37140

cagggaagtt ttttggaatg aacagagttg ccgggcggag gtattgcgcc tgctcgctat    37200

cacgccaatc ggcatttttg taatccacta ccaagcacag gtcatcaaca gtgaattgtt    37260

cccgaagacg ggcgcgaata ttctccagcg acgtgctgca tacctggtag cgtgagccag    37320

tagtctgatt caggtaagac aaaacctgtc tggcctgatc agtaatcaca acctcagggt    37380

cgggttgcgc cgcaaccgga caagagggtt ttgaagttac ttgtggttct tgttttgatt    37440

ttactgacgg atccccacca gattctgacg ggtcaaaacc gccttttttg ctggatttcg    37500

acgcctcaaa ttttgacggg tcggattttg atgcatcaga ttttgatggg tcagattttg    37560

atgcgtcaga ttctgacagg tgagaaaaag cagcctctcg caacttaacg acgttaagct    37620

gatatacgtt cgatgcgtta cggttcccat tacggcgctg cttacgggaa agccagccat    37680

ccttctcaag ctgagcaagg gccgtcctta ccgtactttc tccagcaccg atttgacgtg    37740

cgatcgtgcc aatagacggc cagctaacac cctcatcact actgaagtcg gccagacgcg    37800

ccatgatggc aacgctggat aacttcatgc ctgacgaagc gcatgcatcc catacgtaac    37860

cggttaattt agtgctcatg gtcgtccttt aattctgtaa atttacgctg gaattgttca    37920

agagggctga agcactcatg atcgtaccct tcgcgaaggt atataacgcg ctgtgtatct    37980

ggctcccagc ggacaactct gacgggaact ccgtagtgat ctctgaaccg ccggttaact    38040

tcagccattc ctcgcgcccc ttctcgttca tctgaacaaa tgcttctacc atcaagtctg    38100

ctggctggta gttgcctcca tcagccgcgt tatttatgat ttccacatag ccgaactggg    38160

catctttacc caccagcggc aaacatctga attgcttagc tggtctgaat cggtttacac    38220

tgttcatgcg ttagtttctc cactgatacg acacgccaag gcgcccggag ctgcacactc    38280

gcgggcgtca ccttttctgc ctgttgaaac gaatacgtca atcgcctgat ctgaaacacc    38340

aaccccataa agcgccataa atcccaggaa cccgtgaatc tggtggcgga gcttcttact    38400

gaataattct gaaagcattt tgcgctctga tgaatcaatt accccatcag ccgctgctgc    38460

catcttggca ttagccagct caccagatgc tgctgccgct ttcatctcaa tgctgtacag    38520

ctcaacgtta tccaggctct cagcagttgg aacatccacc agccatttcc cttttcggtt    38580

cgcctggtac tcggccaagt aacaagaacc agacaggtcc tccatccgtt ccagttctgc    38640

caaggtaaag aaccgactgc cacacttctg gtacaggtgg ttgtggaact ggtcgatagt    38700

catccctaaa tcggaagcca tacctaagcg accatgcttg tgtgccttac acatcaggcg    38760

gattgctgta tttatgctgt ctaccatgtt gatttccctc tggtagttaa taatcaactt    38820

aaagttgact attgttgtta gcggaaggta tgccgtcatt tttgttcgga taaatatcag    38880

gtcgtaattg atggggagtt actacccatc cgccccattg gcagagttga ataactcttt    38940

cagaaggtac tcggttcttt gcaatccagt tcgcaacaga ttgaactgat tggaattcaa    39000

accgccttga tacctctgaa atcgacccga tcgccttcac agctttagct gttacattct    39060

tgtgttgaga tgacatgtgt tctcctatga ctaagcctgc atcaatacta cttatagtag    39120

caattattag caacttaaaa tagaaatgac aactatgcct tgtgcgctta atcttctact    39180

tatggtggaa aatgctaaat acaaagactt tgccgaaagg ctaaacaggt ctctccaaga    39240

gcaatctatt ggagttaaag aattgtcaga gttcagtggt gtctcgtatg agatggcgcg    39300

gcgctacact cttggtactg caaagccgag agatgagaag atgattcgaa ttgcagaaag    39360

acttgccgtc tcaccggctt atcttgatta tggtgtgcct gttaatggtg gcgacgcgcc    39420

agccaaaggc acggtcagaa tagagcaatt ggatgttcat gcttcagccg gttccggata    39480

tataaaccaa ccattcccta caatagtgag ctcaatagag attccagaag agaggatctt    39540

cgagttgttt ggtcgtagaa gccttgatgg catcgtcatg ataaatgttg atggcgatag    39600

catgatgccc acgctttgcc caaaggacct gcttttcata gacagcaagg ttgaacaatt    39660

cagcggcgac ggcgtttatg tgttcaattt tgaagacagt acgttcgtta aacgtttgca    39720

gaaggtaaaa gggcgccgac tggcagttct ttcagacaat gaacattacc cgcccttctt    39780

catagaggag catgaaatga atgaactata catattcggc aagctaatca gatgcttacc    39840

tctaaaaatg atagagtttg gctaataatt aattcatcaa gaaaccggcg aaagccggtt    39900

ttttttacgc ctccaattcc tcacctcata acactacact actaaaaatt tcattttcta    39960

ctttttgttg ttgcaattat ctacttaaag tagctatagt cattgcatcg aaagcgaaca    40020

ggcaggacgc ccacgaagta gccgccggtg gcatatgaat aaccggatga ttcgctgaca    40080

gaaaacttag gttgggggta gaggtttaca tgaatcattt attcacatgc tcattttgcg    40140

gagcaaccga actgggagcg ataaagatcg tcgcaaaagg tggtaaggac gaacctgcca    40200

tctgttcgga atgcgtagtc acatgtgtag aaaaaatgat cctgactaaa aaatcagagg    40260

ctgaaaaacc aacctctgat aacgaaataa tatcagtcga taaaaaacta tttaaagagc    40320

ttcttcagct tgtcctcaac cttcctgatt tcggaagtaa gctggctgct gttgacattg    40380

atagtagctc cacatcgaca agtgaaactt ttgttcgact tgagccaagc gattttcttc    40440

ttcgtcttag tgccgcactt agggcatgcg ggtaacgtaa tttcctggtt atcaaaagcg    40500

cccataaaca tccctcttgg ttgtgtgaga acaccaagat accaccgcgc ctgatgtggt    40560

taaaagcagg ctaaagcaat aacaagtaac tccctgttct ggcggcccgg tgttttcccg    40620

tgtatttccg gtaaccgcca gcctttttca gggcacaaca gaaaagggca tcaccgggcg    40680

acgggctcat aacccaatcc acccgggcaa aaagaaagcg gtctctgcaa gccgccgacc    40740

aatgcaggtg cccttctctg ttgtgtatgg agaaactaac tttttagcgt ctgtgcagat    40800

gcgctgagga accgagaatg aataatccgt ttttcaaaaa tatgttggtg tatcgcatta    40860

gtcgcgattt caccatcaac caggaagagc tggaacagca gcttgaacta tttcgcttca    40920

ctccatgcgg tagccaggat atggcaaaaa ccggttgggt atcaccactt ggtcagctgt    40980

cagatcgctt gcatcacact gtcaataatc aagtgttgtt ggttattcgc cgggaagaaa    41040

aaatactgcc atctcctgtc attactgaag aactgcgcaa gcgtgtgtcg cgtctagaat    41100

ccgatcaggg gcgtcgcctc aaaaaaactg agaaagattc gctgcgtgat gaagtgttgc    41160

actccctgct tcctcgggcg ttctccaaaa actcgactgt tggtttgtgg atcaacgtca    41220

ccgacggtct gatcatggtt gatgcagcca gcgctaaacg tgccgaagac tcactggccc    41280

tgcttcgtaa aactctcggt tctctcccgg tggtaccgct gactatggaa acgccgatcg    41340

aactaactat gaccgactgg gttcgttccg gtagtgcgcc tgctggcttt ggcctgggtg    41400

atgaagccga actgaaagct attcttgaag atggcggtat tggacgcttt aaaaaacaga    41460

ctctggtcag tgacgaaatt catgtgcatc tggaagctgg caaagtagtt acaaagctgt    41520

ctatcgactg gcaacagcgc attcagttcg ttctttgcga tgacggcagc atcaaacgcc    41580

ttaagttctc taatgagatt acagaacaaa acgacgatat cgaccgtgag gatgcggctc    41640

agcggttcga cgctgacttt gttctgatga ccggcgagct tatctctctc attaacggat    41700

taacaacctc tctcggcggc gaagccaagc gataaacacc aggcaacaat tacccccata    41760

agcatgggtt gggttgctgc acgctaaatt cagcaattca ttaatttaat ggcgcggtgc    41820

agcgcgccaa tatggagaaa accatgagct acattcagac attatccggc aaacatttta    41880

attacctcga tatccaacag gacgatatcg tgatcgagga tattgctacc gcgttgtctc    41940

atatctgccg ctttgcaggg catcttcctg agttttacag tgtcggccag catagcgttt    42000

taaccagcca cctcgttccg caggagtttg cattagaagc actgcttcat gatgctgctg    42060

aagcctacct gcaggacatc ccctccccac ttaagcgcct gcttccggat taccaggcaa    42120

tcgaagctcg tgtggacgca gccattcggc agaagttcgg tctaccaact gagcaacacc    42180

caaccgtgaa atatgccgac ctggtgatgc tcgccagcga acgccgcgat tttgagattg    42240

acgaaggttc catttggcca tgcctcgagg gagttgtccc aacggattta ttcattatca    42300

acccagttcg tcctggccag tcatacggca tgttcatcaa tcgctttaac gagttgatgg    42360

agcagcgcca atgcgccgca tgaaggtaaa agaactcgta gcggaggcgt ttgcctccgt    42420

tgctgaattg ccaccaaagc atgcgccgct tatgcgcgaa gtcgccacca gactggacgc    42480

tacgttcgca gcattaaaag agtctctggt gcaactggaa caggaacgta aagataaaac    42540

gccatgaccg tatttgaata tctccaggct catccgaata ccaccagcgg tgaaatcgcc    42600

aaaggtatga acaaaaagac cccagcggtc gccggagcat tatctcagct ctatggcacc    42660

ggtcggatcg tgaagtctgg tgttcgcaag ggtattccaa cataccgcat taacgatatg    42720

ccgtttggtt gcagtaacag cctaaccatg atgtttaacc agctcttgag cagagccaga    42780

caaggagcag cccaatgaca gcactcaaca aacaggcgct gcgtgaagaa ttccagttca    42840

tgcaggacaa ctatagcgac ccggcagacc acgatcggca ggtgatttac atcgaggcgg    42900

aggcgctgct ggatgagttg gaagccaaag actcaacgat agcagcacaa caacatgaga    42960

tccgtatgtt gctgaatgcg cttgaggaaa aaccatgccc gaaatgcaac gacacaggaa    43020

tgactgatag tggcggcacg cagccatggg gcgagccgat tgagattgaa tgcgactgcc    43080

gacagcagga tgccaacacc gcagaacttg tagccgctgg cattggcgtg aagggggagt    43140

gagatggata aattaatcaa acctaccgcc aaaggtaaat atgacggttc atgtgattat    43200

ctttgctcgg aagatgcgcg attcatcgtt atgcgcggcg attatacgga agcggaaata    43260

attcaggctt ctgtgtctca agatgtaatc gactcggatg gtgcggctga ttttgcaagt    43320

agcgcccgct attatcagtg ctggtacaaa gttagcccaa taggtggtca ggatggctat    43380

tcaggctggc atcatcctcg tgattcgccg tgtcgcggtg catatttcgc atcagttttg    43440

caatgggatt aaggaggact aacccatgac aactaacaac cacccggcgc acggtcctgt    43500

atcactcgat cgcctgcacc agatacgcga acacctgctg catgataccc aatactcaaa    43560

cggcgggaac agagcctaca ttctcgctga tgtattgaag gtgattgatg gggctattgc    43620

ccgcgagctg gtacgccgtg agcatgcagc gtggtcacag gctactttcg gcgatgtcgg    43680

tccagttggt ccgctgaagc acctttccaa agaagcgctc gaggctgctg ctgaaccagg    43740

cgaccttagc gaatgggctg acatgcaatt cctgttatgg gatgcgcaac gtcgtgccgg    43800

tatcagtgat gagcagatta cccaggcaat gataaaaaag ctggctataa ataaggttcg    43860

ccaatggcct gagccgaaag acggggaacc tcgattgcat atcaaagaac agtcagagca    43920

ggagaaaaaa taagaatgtt tagcctgatt cggcgcggtc aaatctacac ggacagtagc    43980

aactggcccg taattatcca tagctgtagt gatcactcgg tccgaattaa acgcaatgat    44040

ggcgagctga gaacgattag catcaaacgc tttaacgaag attttgaacg agtggagcat    44100

gatgagtatc gcaaaatatg tgccgaaata gagcaggaaa caaacctgaa aaacctacgt    44160

gcgatgcgtc gcggcaagat tactgaatag ccaaacagga gaatatttaa cgtgaacaac    44220

ttaatgatcg accttgagtc catgggcaaa aaaccgaatg cccctattgt ctccattggt    44280

gccgtattct tcgatccgca aagcggtgaa ctgggtcagg agttttacac cgctgttaat    44340

cttgaaagcg ctatggagca gggagcggtg ccggatggtg acactattct gtggtggtta    44400

agacaaagct cagaagcacg atcagcaatc tgtgttgatg atgcgatgcc gatatcatct    44460

gccctatctg aactgagcca tttcattaat cggcattctg ataaccctaa atatttaaaa    44520

gtttggggca atggagctac tttcgacaac gttatattgc gcggcgcata tgagcgtgcc    44580

ggccaggttt gcccgtggca attttggaat gatcacgacg tcagaaccat cgtcacatta    44640

ggcagatctg taggtttcga tcctaagcgt gatatgccat ttgatggggt tgcacataac    44700

gcactggctg atgcccgcca ccaggcgaaa tatgtttcag cgatttggca gaaactaatc    44760

ccaaccacca gcaacagcta aagttttccc cgggtgcagc cgggataatg gagaaataac    44820

tatgagcaat attttccagt tagctcccaa cgattgggtt tgtgaaagcg ttttgatcgc    44880

ggttactggg ctcaaacccg gaaccatcct ccgtgccaga aaagaatgct ggatgattgg    44940

gagggagtat atccacgtat cgcctgacgg aaatcctaaa ccttccagtg agtgcatgta    45000

taacagaaag gctgtagatg cctgggtcgc ttcaatgaaa agcaagcaac cagggtgatt    45060

tgatgccatg aaaaaggtaa gctcgtatcg ctcttgggcg tctggaggta acaccaatgg    45120

ataaagtcac atatccaaca ggcgtcgaaa accacggtgg cacattacgc atctggttta    45180

attttaaagg taagcgtgtc agggaaagtc tcggtgtccc tgacaccgct aagaacagga    45240

agatagccgg ggaactgcgg acatcagtat gttttgccat ccgcacagga acctttgatt    45300

atgcaaccca gtttcctgac tcccctaacc tcaaggcttt tggtgtaagt aaaaaagaca    45360

ttacagtgaa agaacttgaa gaaaaatggc tggatctgaa acggatggaa atctgcgcga    45420

acgcatttaa tcgctatgaa tctgtcgcaa ggaatatggt gccgaggatc ggaggtaatc    45480

gcctggtgtc agcagtaacc aaagaggaat tgctgtatct gaggaaatat ttgctaactg    45540

gttatcagaa tccgacgaaa aacaaagccc cggcaaaagg gcgaagcgtt gttactgtga    45600

actattacat gacgacaatg gccggaatgt ttcagtttgc tgcggatcac ggttacttag    45660

aggtgaaccc attcgaggga attaagcctc tgaaaaaagc cagggcagaa ccagatcctc    45720

tgtctcgtga tgaatttatt cgcctgatag atgcatgccg gcatcagcag acgaaaaacc    45780

tgtggtcatt agcagtgtac acaggaatgc gtcacgggga actggtctcc ctggcctggg    45840

aagatatcga cctgaaggct ggaacaatta ccgtcagacg taattatacg aaacttggtg    45900

agttcactct accgaaaacc gaggcaagca cagatcgagt ggtgcatctt atccagcccg    45960

caatcagtat cctgaaaaat caggctgaaa tgacaaggct gggcaggcaa tatcacattg    46020

aagtgcagtt acgtgagtac ggccgttcgg tgaaccatga gtgtacattc gtctttaatc    46080

cgcatgtggt cagacgcagt aagcaggtcg gatttatcta ccgggtcgat tcagtaggcg    46140

actcatggga agcggcactt aagcgtgcgg ggatcagaca cagaaaggcg taccagtcac    46200

gacacaccta tgcgtgctgg tcattatcag ctggtgcaaa ccctagtttt attgccagtc    46260

agatggggca tgcgagcgcg cagatggtgt tcaatgttta cggtgcatgg atggctgaca    46320

gcagcgcaga gcagatcgca atgctgaatc agaagctggc agattttgcc ccattgatgc    46380

cccatagcca cgagaacagt acgggaggat tattaaaatc agtaagttaa cccctaacgc    46440

ccgtcatgtt aactgtgtgg agggtaacac cacgctttat gccctgccga aacccgaggt    46500

tgtcctgcgc tggcgtgagc agaccacaga tgacttccgc ttctgtttta agtttccggc    46560

gaccatttcg catcaggcag cattacggca ttgcgatgat ttagtgactg aatttttgac    46620

ccgcatgtca ccgttggctc cgcgcattgg acaatactgg ctgcaactgc ctgccacatt    46680

cggcccacgg gagctgcctg cgctttggca ttttctcgat tctcttcccg gtgaatttaa    46740

ttatggggtg gaagtccgcc atccacagtt tttcgccaaa ggggaagagg aacaaacgct    46800

taatcgcggt ttacatcagc gcggcgttaa tcgggtgatt ttagacagcc gcccggttca    46860

tgcagcacgt ccatacagtg aagctattcg cgacgctcaa cgaaaaaaac ctaaagttcc    46920

ggtacatgct gtactgacgg cgaaaaatcc actgatccgt tttatcggta gtgatgatat    46980

gacgcaaaac cgggaattat ttcaggtctg gttacaaaaa ttagcgcagt ggcatcagac    47040

cactacgcct tatctttttt tacatacgcc agatattgcc caggccccgg aactggtaca    47100

taccctgtgg gaagacttac gtaaaacgct tccagagatc ggagcagttc cggctattcc    47160

acagcaatct tctcttttct gaatttgcca cctatcatag acaggtgcca tcggccattt    47220

taaagggagt ttgtatggta agcgcgctgt atgccgtttt aagtgcgttg ttattaatga    47280

agttctcttt tgatgtcgtt cgcctgcgaa tgcagtaccg cgttgcctat ggcgacggcg    47340

gttttagcga actgcaaagc gctattcgca ttcatggtaa cgcggtggaa tatattccta    47400

tcgcgattgt gttgatgctg tttatggaaa tgaatggcgc agaaacctgg atggtgcata    47460

tttgcggcat cgttttgctt gctggtcgtc tgatgcatta ttacggtttt catcaccgtc    47520

tgttccgctg gcgacgttct ggcatgagcg ccacctggtg tgcgctgttg ctgatggtgc    47580

tggcgaatct ttggtatatg ccctgggagt tggttttctc cctgcgttag cgcacaatac    47640

gccactttct ttttcccgga tttttacgtt atgtctcacc gcgacacgct attttctgcc    47700

cctatcgcca gactgggcga ctggaccttt gatgaacggg tagctgaagt cttcccggat    47760

atgatccagc gttccgttcc cggctattcc aatattattt ccatgattgg tatgttagcc    47820

gagcgcttcg ttcaacctgg tacgcaggtt tacgatctgg gttgttctct gggcgcggcg    47880

acgctctcgg tgcgtcgcaa cattcatcat gataattgca aaattattgc catcgacaac    47940

tccccggcga tgattgaacg ctgccgtcgt catattgacg cctataaagc ccctacgcca    48000

gtagacgtta ttgaaggtga tattcgcgat atcgccattg aaaacgcatc gatggtggtg    48060

ctgaatttta ccctgcaatt cctggaacct tccgagcgcc aggcgttact ggataaaatt    48120

tatcaagggc tgaacccggg cggtgcgctg gtgctttcgg aaaaattcag tttcgaagat    48180

gccaaagttg gtgaactgct gttcaacatg caccacgact ttaaacgtgc caacggttac    48240

agcgaactgg agatcagcca gaaacgcagc atgctggaaa acgtgatgct gaccgattcc    48300

gtggaaaccc ataaagcacg cctgcataaa gccggttttg agcatagcga gctgtggttc    48360

cagtgcttta actttggttc actggtggca ttaaaagcag aggacgctgc atgatcgact    48420

ttggtaactt ttattctctg attgccaaaa atcatctttc acactggctc gaaacgctgc    48480

ccgcgcagat tgctaactgg cagcgcgagc agcagcacgg gctgtttaag cagtggtcca    48540

acgcggtgga atttctgcct gaaattaaac cgtatcgtct ggatttattg catagcgtaa    48600

ccgccgaaag cgaagagcca ctgagcgccg ggcaaattaa gcgcattgaa acgctgatgc    48660

gcaacctgat gccgtggcgc aaagggccgt tctcactgta tggcgtcaac atcgataccg    48720

aatggcgttc cgactggaaa tgggatcgcg ttatgcccca tctttctgat ttaaccgggc    48780

gcaccattct tgatgtcggc tgtggcagcg gttatcacat gtggcgcatg attggcgcag    48840

gggcgcatct ggcggtgggt atcgatccca cgcagctatt cctctgccag tttgaagcag    48900

tgcgtaaact gctgggtaac gatcagcgcg cacatttgtt accgttaggt attgaacaac    48960

ttccggcact gaaagccttt gataccgtct tttcgatggg cgtgctttat catcgtcgtt    49020

caccgctgga gcatctctgg cagttaaaag accaactggt gaatgaaggc gaactggtgc    49080

tggaaacgct ggttattgat ggcgacgaaa acacggtgct ggtgccgggc gatcgttacg    49140

ctcaaatgcg taatgtctat ttcattcctt ccgcgctggc gctgaaaaac tggctgaaga    49200

agtgtggttt tgttgatatt cgcattgcag atgtgagcgt taccaccaca gaagagcagc    49260

gacgcaccga atggatggtc accgagtctc tggccgattt tctcgacccg catgatccgg    49320

gtaaaacggt ggaaggttat cctgcgccta aacgcgcggt gctgattgcg cgcaagccgt    49380

aaaggtctgg taatactgcc ggatgcggcg tgaacgcctt atccggccta caaagtcttg    49440

ctaattcaat atattgcagg ggctatgtag gcctgataag catagcgcat caggca        49496


<210> 1434
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1434
tggaggcttt aagaaatacc tcgatgtgaa caaccgcctg ccacgaatct tcgtcaagcg       60

attacacgtc ttgagcgat                                                    79


<210> 1435
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1435
gataatggtg agattatccc cggttatacc ggacttatcg cctattcaga atcactggat       60

ctgacatggg aattagcca                                                    79


<210> 1436
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1436
gtgattaagt acgtgaaatc gactgaac                                          28


<210> 1437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1437
ctctgtcggc aacatgagga                                                   20


<210> 1438
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1438
tggaggcttt aagaaatacc tcgatgtgaa caaccgcctg ccacgaatct tcgtcaagcg       60

attacacgtc ttgagcgat                                                    79


<210> 1439
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1439
gataatggtg agattatccc cggttatacc ggacttatcg cctattcaga atcactggat       60

ctgacatggg aattagcca                                                    79


<210> 1440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1440
tggaggcttt aagaaatacc                                                   20


<210> 1441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1441
gctggcgatt caggttcatc                                                   20


<210> 1442
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1442
gctggcgatt caggttcatc gttttcaccg taacacgcca                             40


<210> 1443
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1443
tcgacattta tcccttgcgg cgaatactta cagccatagc aa                          42


<210> 1444
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1444
ggcgcgcctt gacaattaat catccggctc ctaggatgtg tggagggac                   49


<210> 1445
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1445
ggcgcgcctt gacatcagga aaatttttct gtataataga ttcatctcaa                  50


<210> 1446
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1446
ggcgcgcctt gacataaagt ctaacctata ggatacttac agccatacaa g                51


