                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
       THE TRUSTEES OF PRINCETON UNIVERSITY
       THE SIMONS FOUNDATION, INC.
       LIM, Wendell  A.
       TROYANSKAYA, Olga  G.
       VANDERSLUIS, Benjamin
       DANNENFELSER, Ruth
 
<120>  SYSTEMS AND METHODS FOR TARGETING CANCER CELLS

<130>  UCSF-569WO

<150>  US 62/653,929
<151>  2018-04-06

<160>  543   

<170>  PatentIn version 3.5

<210>  1
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Pro Ala Glu Pro Cys Ala Gly Gln Gly Val Trp Asn Gln 
1               5                   10                  15      


Thr Glu Pro Glu Pro Ala Ala Thr Ser Leu Leu Ser Leu Cys Phe Leu 
            20                  25                  30          


Arg Thr Ala Gly Val Trp Val Pro Pro Met Tyr Leu Trp Val Leu Gly 
        35                  40                  45              


Pro Ile Tyr Leu Leu Phe Ile His His His Gly Arg Gly Tyr Leu Arg 
    50                  55                  60                  


Met Ser Pro Leu Phe Lys Ala Lys Met Val Ala Ala Ile Pro Gly Ser 
65                  70                  75                  80  


Leu Glu Pro Gly Asn Val Arg Gly Arg Gln Gly Thr Gly Trp Asn Leu 
                85                  90                  95      


Val Lys Ser 
            


<210>  2
<211>  1503
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Pro Ala Glu Pro Cys Ala Gly Gln Gly Val Trp Asn Gln 
1               5                   10                  15      


Thr Glu Pro Glu Pro Ala Ala Thr Ser Leu Leu Ser Leu Cys Phe Leu 
            20                  25                  30          


Arg Thr Ala Gly Val Trp Val Pro Pro Met Tyr Leu Trp Val Leu Gly 
        35                  40                  45              


Pro Ile Tyr Leu Leu Phe Ile His His His Gly Arg Gly Tyr Leu Arg 
    50                  55                  60                  


Met Ser Pro Leu Phe Lys Ala Lys Met Val Leu Gly Phe Ala Leu Ile 
65                  70                  75                  80  


Val Leu Cys Thr Ser Ser Val Ala Val Ala Leu Trp Lys Ile Gln Gln 
                85                  90                  95      


Gly Thr Pro Glu Ala Pro Glu Phe Leu Ile His Pro Thr Val Trp Leu 
            100                 105                 110         


Thr Thr Met Ser Phe Ala Val Phe Leu Ile His Thr Glu Arg Lys Lys 
        115                 120                 125             


Gly Val Gln Ser Ser Gly Val Leu Phe Gly Tyr Trp Leu Leu Cys Phe 
    130                 135                 140                 


Val Leu Pro Ala Thr Asn Ala Ala Gln Gln Ala Ser Gly Ala Gly Phe 
145                 150                 155                 160 


Gln Ser Asp Pro Val Arg His Leu Ser Thr Tyr Leu Cys Leu Ser Leu 
                165                 170                 175     


Val Val Ala Gln Phe Val Leu Ser Cys Leu Ala Asp Gln Pro Pro Phe 
            180                 185                 190         


Phe Pro Glu Asp Pro Gln Gln Ser Asn Pro Cys Pro Glu Thr Gly Ala 
        195                 200                 205             


Ala Phe Pro Ser Lys Ala Thr Phe Trp Trp Val Ser Gly Leu Val Trp 
    210                 215                 220                 


Arg Gly Tyr Arg Arg Pro Leu Arg Pro Lys Asp Leu Trp Ser Leu Gly 
225                 230                 235                 240 


Arg Glu Asn Ser Ser Glu Glu Leu Val Ser Arg Leu Glu Lys Glu Trp 
                245                 250                 255     


Met Arg Asn Arg Ser Ala Ala Arg Arg His Asn Lys Ala Ile Ala Phe 
            260                 265                 270         


Lys Arg Lys Gly Gly Ser Gly Met Lys Ala Pro Glu Thr Glu Pro Phe 
        275                 280                 285             


Leu Arg Gln Glu Gly Ser Gln Trp Arg Pro Leu Leu Lys Ala Ile Trp 
    290                 295                 300                 


Gln Val Phe His Ser Thr Phe Leu Leu Gly Thr Leu Ser Leu Ile Ile 
305                 310                 315                 320 


Ser Asp Val Phe Arg Phe Thr Val Pro Lys Leu Leu Ser Leu Phe Leu 
                325                 330                 335     


Glu Phe Ile Gly Asp Pro Lys Pro Pro Ala Trp Lys Gly Tyr Leu Leu 
            340                 345                 350         


Ala Val Leu Met Phe Leu Ser Ala Cys Leu Gln Thr Leu Phe Glu Gln 
        355                 360                 365             


Gln Asn Met Tyr Arg Leu Lys Val Leu Gln Met Arg Leu Arg Ser Ala 
    370                 375                 380                 


Ile Thr Gly Leu Val Tyr Arg Lys Val Leu Ala Leu Ser Ser Gly Ser 
385                 390                 395                 400 


Arg Lys Ala Ser Ala Val Gly Asp Val Val Asn Leu Val Ser Val Asp 
                405                 410                 415     


Val Gln Arg Leu Thr Glu Ser Val Leu Tyr Leu Asn Gly Leu Trp Leu 
            420                 425                 430         


Pro Leu Val Trp Ile Val Val Cys Phe Val Tyr Leu Trp Gln Leu Leu 
        435                 440                 445             


Gly Pro Ser Ala Leu Thr Ala Ile Ala Val Phe Leu Ser Leu Leu Pro 
    450                 455                 460                 


Leu Asn Phe Phe Ile Ser Lys Lys Arg Asn His His Gln Glu Glu Gln 
465                 470                 475                 480 


Met Arg Gln Lys Asp Ser Arg Ala Arg Leu Thr Ser Ser Ile Leu Arg 
                485                 490                 495     


Asn Ser Lys Thr Ile Lys Phe His Gly Trp Glu Gly Ala Phe Leu Asp 
            500                 505                 510         


Arg Val Leu Gly Ile Arg Gly Gln Glu Leu Gly Ala Leu Arg Thr Ser 
        515                 520                 525             


Gly Leu Leu Phe Ser Val Ser Leu Val Ser Phe Gln Val Ser Thr Phe 
    530                 535                 540                 


Leu Val Ala Leu Val Val Phe Ala Val His Thr Leu Val Ala Glu Asn 
545                 550                 555                 560 


Ala Met Asn Ala Glu Lys Ala Phe Val Thr Leu Thr Val Leu Asn Ile 
                565                 570                 575     


Leu Asn Lys Ala Gln Ala Phe Leu Pro Phe Ser Ile His Ser Leu Val 
            580                 585                 590         


Gln Ala Arg Val Ser Phe Asp Arg Leu Val Thr Phe Leu Cys Leu Glu 
        595                 600                 605             


Glu Val Asp Pro Gly Val Val Asp Ser Ser Ser Ser Gly Ser Ala Ala 
    610                 615                 620                 


Gly Lys Asp Cys Ile Thr Ile His Ser Ala Thr Phe Ala Trp Ser Gln 
625                 630                 635                 640 


Glu Ser Pro Pro Cys Leu His Arg Ile Asn Leu Thr Val Pro Gln Gly 
                645                 650                 655     


Cys Leu Leu Ala Val Val Gly Pro Val Gly Ala Gly Lys Ser Ser Leu 
            660                 665                 670         


Leu Ser Ala Leu Leu Gly Glu Leu Ser Lys Val Glu Gly Phe Val Ser 
        675                 680                 685             


Ile Glu Gly Ala Val Ala Tyr Val Pro Gln Glu Ala Trp Val Gln Asn 
    690                 695                 700                 


Thr Ser Val Val Glu Asn Val Cys Phe Gly Gln Glu Leu Asp Pro Pro 
705                 710                 715                 720 


Trp Leu Glu Arg Val Leu Glu Ala Cys Ala Leu Gln Pro Asp Val Asp 
                725                 730                 735     


Ser Phe Pro Glu Gly Ile His Thr Ser Ile Gly Glu Gln Gly Met Asn 
            740                 745                 750         


Leu Ser Gly Gly Gln Lys Gln Arg Leu Ser Leu Ala Arg Ala Val Tyr 
        755                 760                 765             


Arg Lys Ala Ala Val Tyr Leu Leu Asp Asp Pro Leu Ala Ala Leu Asp 
    770                 775                 780                 


Ala His Val Gly Gln His Val Phe Asn Gln Val Ile Gly Pro Gly Gly 
785                 790                 795                 800 


Leu Leu Gln Gly Thr Thr Arg Ile Leu Val Thr His Ala Leu His Ile 
                805                 810                 815     


Leu Pro Gln Ala Asp Trp Ile Ile Val Leu Ala Asn Gly Ala Ile Ala 
            820                 825                 830         


Glu Met Gly Ser Tyr Gln Glu Leu Leu Gln Arg Lys Gly Ala Leu Val 
        835                 840                 845             


Cys Leu Leu Asp Gln Ala Arg Gln Pro Gly Asp Arg Gly Glu Gly Glu 
    850                 855                 860                 


Thr Glu Pro Gly Thr Ser Thr Lys Asp Pro Arg Gly Thr Ser Ala Gly 
865                 870                 875                 880 


Arg Arg Pro Glu Leu Arg Arg Glu Arg Ser Ile Lys Ser Val Pro Glu 
                885                 890                 895     


Lys Asp Arg Thr Thr Ser Glu Ala Gln Thr Glu Val Pro Leu Asp Asp 
            900                 905                 910         


Pro Asp Arg Ala Gly Trp Pro Ala Gly Lys Asp Ser Ile Gln Tyr Gly 
        915                 920                 925             


Arg Val Lys Ala Thr Val His Leu Ala Tyr Leu Arg Ala Val Gly Thr 
    930                 935                 940                 


Pro Leu Cys Leu Tyr Ala Leu Phe Leu Phe Leu Cys Gln Gln Val Ala 
945                 950                 955                 960 


Ser Phe Cys Arg Gly Tyr Trp Leu Ser Leu Trp Ala Asp Asp Pro Ala 
                965                 970                 975     


Val Gly Gly Gln Gln Thr Gln Ala Ala Leu Arg Gly Gly Ile Phe Gly 
            980                 985                 990         


Leu Leu Gly Cys Leu Gln Ala Ile  Gly Leu Phe Ala Ser  Met Ala Ala 
        995                 1000                 1005             


Val Leu  Leu Gly Gly Ala Arg  Ala Ser Arg Leu Leu  Phe Gln Arg 
    1010                 1015                 1020             


Leu Leu  Trp Asp Val Val Arg  Ser Pro Ile Ser Phe  Phe Glu Arg 
    1025                 1030                 1035             


Thr Pro  Ile Gly His Leu Leu  Asn Arg Phe Ser Lys  Glu Thr Asp 
    1040                 1045                 1050             


Thr Val  Asp Val Asp Ile Pro  Asp Lys Leu Arg Ser  Leu Leu Met 
    1055                 1060                 1065             


Tyr Ala  Phe Gly Leu Leu Glu  Val Ser Leu Val Val  Ala Val Ala 
    1070                 1075                 1080             


Thr Pro  Leu Ala Thr Val Ala  Ile Leu Pro Leu Phe  Leu Leu Tyr 
    1085                 1090                 1095             


Ala Gly  Phe Gln Ser Leu Tyr  Val Val Ser Ser Cys  Gln Leu Arg 
    1100                 1105                 1110             


Arg Leu  Glu Ser Ala Ser Tyr  Ser Ser Val Cys Ser  His Met Ala 
    1115                 1120                 1125             


Glu Thr  Phe Gln Gly Ser Thr  Val Val Arg Ala Phe  Arg Thr Gln 
    1130                 1135                 1140             


Ala Pro  Phe Val Ala Gln Asn  Asn Ala Arg Val Asp  Glu Ser Gln 
    1145                 1150                 1155             


Arg Ile  Ser Phe Pro Arg Leu  Val Ala Asp Arg Trp  Leu Ala Ala 
    1160                 1165                 1170             


Asn Val  Glu Leu Leu Gly Asn  Gly Leu Val Phe Ala  Ala Ala Thr 
    1175                 1180                 1185             


Cys Ala  Val Leu Ser Lys Ala  His Leu Ser Ala Gly  Leu Val Gly 
    1190                 1195                 1200             


Phe Ser  Val Ser Ala Ala Leu  Gln Val Thr Gln Thr  Leu Gln Trp 
    1205                 1210                 1215             


Val Val  Arg Asn Trp Thr Asp  Leu Glu Asn Ser Ile  Val Ser Val 
    1220                 1225                 1230             


Glu Arg  Met Gln Asp Tyr Ala  Trp Thr Pro Lys Glu  Ala Pro Trp 
    1235                 1240                 1245             


Arg Leu  Pro Thr Cys Ala Ala  Gln Pro Pro Trp Pro  Gln Gly Gly 
    1250                 1255                 1260             


Gln Ile  Glu Phe Arg Asp Phe  Gly Leu Arg Tyr Arg  Pro Glu Leu 
    1265                 1270                 1275             


Pro Leu  Ala Val Gln Gly Val  Ser Phe Lys Ile His  Ala Gly Glu 
    1280                 1285                 1290             


Lys Val  Gly Ile Val Gly Arg  Thr Gly Ala Gly Lys  Ser Ser Leu 
    1295                 1300                 1305             


Ala Ser  Gly Leu Leu Arg Leu  Gln Glu Ala Ala Glu  Gly Gly Ile 
    1310                 1315                 1320             


Trp Ile  Asp Gly Val Pro Ile  Ala His Val Gly Leu  His Thr Leu 
    1325                 1330                 1335             


Arg Ser  Arg Ile Ser Ile Ile  Pro Gln Asp Pro Ile  Leu Phe Pro 
    1340                 1345                 1350             


Gly Ser  Leu Arg Met Asn Leu  Asp Leu Leu Gln Glu  His Ser Asp 
    1355                 1360                 1365             


Glu Ala  Ile Trp Ala Ala Leu  Glu Thr Val Gln Leu  Lys Ala Leu 
    1370                 1375                 1380             


Val Ala  Ser Leu Pro Gly Gln  Leu Gln Tyr Lys Cys  Ala Asp Arg 
    1385                 1390                 1395             


Gly Glu  Asp Leu Ser Val Gly  Gln Lys Gln Leu Leu  Cys Leu Ala 
    1400                 1405                 1410             


Arg Ala  Leu Leu Arg Lys Thr  Gln Ile Leu Ile Leu  Asp Glu Ala 
    1415                 1420                 1425             


Thr Ala  Ala Val Asp Pro Gly  Thr Glu Leu Gln Met  Gln Ala Met 
    1430                 1435                 1440             


Leu Gly  Ser Trp Phe Ala Gln  Cys Thr Val Leu Leu  Ile Ala His 
    1445                 1450                 1455             


Arg Leu  Arg Ser Val Met Asp  Cys Ala Arg Val Leu  Val Met Asp 
    1460                 1465                 1470             


Lys Gly  Gln Val Ala Glu Ser  Gly Ser Pro Ala Gln  Leu Leu Ala 
    1475                 1480                 1485             


Gln Lys  Gly Leu Phe Tyr Arg  Leu Ala Gln Glu Ser  Gly Leu Val 
    1490                 1495                 1500             


<210>  3
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Thr Phe Phe Leu Val Ser Gly Gly Ser Leu Trp Leu Phe Val 
1               5                   10                  15      


Glu Phe Val Leu Ser Leu Leu Glu Lys Met Gln Thr Gln Glu Ile Leu 
            20                  25                  30          


Arg Ile Leu Arg Leu Pro Glu Leu Gly Asp Leu Gly Gln Phe Phe Arg 
        35                  40                  45              


Ser Leu Ser Ala Thr Thr Leu Val Ser Met Gly Ala Leu Ala Ala Ile 
    50                  55                  60                  


Leu Ala Tyr Trp Phe Thr His Arg Pro Lys Ala Leu Gln Pro Pro Cys 
65                  70                  75                  80  


Asn Leu Leu Met Gln Ser Glu Glu Val Glu Asp Ser Gly Gly Ala Arg 
                85                  90                  95      


Arg Ser Val Ile Gly Ser Gly Pro Gln Leu Leu Thr His Tyr Tyr Asp 
            100                 105                 110         


Asp Ala Arg Thr Met Tyr Gln Val Phe Arg Arg Gly Leu Ser Ile Ser 
        115                 120                 125             


Gly Asn Gly Pro Cys Leu Gly Phe Arg Lys Pro Lys Gln Pro Tyr Gln 
    130                 135                 140                 


Trp Leu Ser Tyr Gln Glu Val Ala Asp Arg Ala Glu Phe Leu Gly Ser 
145                 150                 155                 160 


Gly Leu Leu Gln His Asn Cys Lys Ala Cys Thr Asp Gln Phe Ile Gly 
                165                 170                 175     


Val Phe Ala Gln Asn Arg Pro Glu Trp Ile Ile Val Glu Leu Ala Cys 
            180                 185                 190         


Tyr Thr Tyr Ser Met Val Val Val Pro Leu Tyr Asp Thr Leu Gly Pro 
        195                 200                 205             


Gly Ala Ile Arg Tyr Ile Ile Asn Thr Ala Asp Ile Ser Thr Val Ile 
    210                 215                 220                 


Val Asp Lys Pro Gln Lys Ala Val Leu Leu Leu Glu His Val Glu Arg 
225                 230                 235                 240 


Lys Glu Thr Pro Gly Leu Lys Leu Ile Ile Leu Met Asp Pro Phe Glu 
                245                 250                 255     


Glu Ala Leu Lys Glu Arg Gly Gln Lys Cys Gly Val Val Ile Lys Ser 
            260                 265                 270         


Met Gln Ala Val Glu Asp Cys Gly Gln Glu Asn His Gln Ala Pro Val 
        275                 280                 285             


Pro Pro Gln Pro Asp Asp Leu Ser Ile Val Cys Phe Thr Ser Gly Thr 
    290                 295                 300                 


Thr Gly Asn Pro Lys Gly Ala Met Leu Thr His Gly Asn Val Val Ala 
305                 310                 315                 320 


Asp Phe Ser Gly Phe Leu Lys Val Thr Glu Lys Val Ile Phe Pro Arg 
                325                 330                 335     


Gln Asp Asp Val Leu Ile Ser Phe Leu Pro Leu Ala His Met Phe Glu 
            340                 345                 350         


Arg Val Ile Gln Ser Val Val Tyr Cys His Gly Gly Arg Val Gly Phe 
        355                 360                 365             


Phe Gln Gly Asp Ile Arg Leu Leu Ser Asp Asp Met Lys Ala Leu Cys 
    370                 375                 380                 


Pro Thr Ile Phe Pro Val Val Pro Arg Leu Leu Asn Arg Met Tyr Asp 
385                 390                 395                 400 


Lys Ile Phe Ser Gln Ala Asn Thr Pro Leu Lys Arg Trp Leu Leu Glu 
                405                 410                 415     


Phe Ala Ala Lys Arg Lys Gln Ala Glu Val Arg Ser Gly Ile Ile Arg 
            420                 425                 430         


Asn Asp Ser Ile Trp Asp Glu Leu Phe Phe Asn Lys Ile Gln Ala Ser 
        435                 440                 445             


Leu Gly Gly Cys Val Arg Met Ile Val Thr Gly Ala Ala Pro Ala Ser 
    450                 455                 460                 


Pro Thr Val Leu Gly Phe Leu Arg Ala Ala Leu Gly Cys Gln Val Tyr 
465                 470                 475                 480 


Glu Gly Tyr Gly Gln Thr Glu Cys Thr Ala Gly Cys Thr Phe Thr Thr 
                485                 490                 495     


Pro Gly Asp Trp Thr Ser Gly His Val Gly Ala Pro Leu Pro Cys Asn 
            500                 505                 510         


His Ile Lys Leu Val Asp Val Glu Glu Leu Asn Tyr Trp Ala Cys Lys 
        515                 520                 525             


Gly Glu Gly Glu Ile Cys Val Arg Gly Pro Asn Val Phe Lys Gly Tyr 
    530                 535                 540                 


Leu Lys Asp Pro Asp Arg Thr Lys Glu Ala Leu Asp Ser Asp Gly Trp 
545                 550                 555                 560 


Leu His Thr Gly Asp Ile Gly Lys Trp Leu Pro Ala Gly Thr Leu Lys 
                565                 570                 575     


Ile Ile Asp Arg Lys Lys His Ile Phe Lys Leu Ala Gln Gly Glu Tyr 
            580                 585                 590         


Val Ala Pro Glu Lys Ile Glu Asn Ile Tyr Ile Arg Ser Gln Pro Val 
        595                 600                 605             


Ala Gln Ile Tyr Val His Gly Asp Ser Leu Lys Ala Phe Leu Val Gly 
    610                 615                 620                 


Ile Val Val Pro Asp Pro Glu Val Met Pro Ser Trp Ala Gln Lys Arg 
625                 630                 635                 640 


Gly Ile Glu Gly Thr Tyr Ala Asp Leu Cys Thr Asn Lys Asp Leu Lys 
                645                 650                 655     


Lys Ala Ile Leu Glu Asp Met Val Arg Leu Gly Lys Glu Ser Gly Leu 
            660                 665                 670         


His Ser Phe Glu Gln Val Lys Ala Ile His Ile His Ser Asp Met Phe 
        675                 680                 685             


Ser Val Gln Asn Gly Leu Leu Thr Pro Thr Leu Lys Ala Lys Arg Pro 
    690                 695                 700                 


Glu Leu Arg Glu Tyr Phe Lys Lys Gln Ile Glu Glu Leu Tyr Ser Ile 
705                 710                 715                 720 


Ser Met 
        


<210>  4
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Thr Phe Phe Leu Val Ser Gly Gly Ser Leu Trp Leu Phe Val 
1               5                   10                  15      


Glu Phe Val Leu Ser Leu Leu Glu Lys Met Gln Thr Gln Glu Ile Leu 
            20                  25                  30          


Arg Ile Leu Arg Leu Pro Glu Leu Gly Asp Leu Gly Gln Phe Phe Arg 
        35                  40                  45              


Ser Leu Ser Ala Thr Thr Leu Asp Ser Gly Gly Ala Arg Arg Ser Val 
    50                  55                  60                  


Ile Gly Ser Gly Pro Gln Leu Leu Thr His Tyr Tyr Asp Asp Ala Arg 
65                  70                  75                  80  


Thr Met Tyr Gln Val Phe Arg Arg Gly Leu Ser Ile Ser Gly Asn Gly 
                85                  90                  95      


Pro Cys Leu Gly Phe Arg Lys Pro Lys Gln Pro Tyr Gln Trp Leu Ser 
            100                 105                 110         


Tyr Gln Glu Val Ala Asp Arg Ala Glu Phe Leu Gly Ser Gly Leu Leu 
        115                 120                 125             


Gln His Asn Cys Lys Ala Cys Thr Asp Gln Phe Ile Gly Val Phe Ala 
    130                 135                 140                 


Gln Asn Arg Pro Glu Trp Ile Ile Val Glu Leu Ala Cys Tyr Thr Tyr 
145                 150                 155                 160 


Ser Met Val Val Val Pro Leu Tyr Asp Thr Leu Gly Pro Gly Ala Ile 
                165                 170                 175     


Arg Tyr Ile Ile Asn Thr Ala Asp Ile Ser Thr Val Ile Val Asp Lys 
            180                 185                 190         


Pro Gln Lys Ala Val Leu Leu Leu Glu His Val Glu Arg Lys Glu Thr 
        195                 200                 205             


Pro Gly Leu Lys Leu Ile Ile Leu Met Asp Pro Phe Glu Glu Ala Leu 
    210                 215                 220                 


Lys Glu Arg Gly Gln Lys Cys Gly Val Val Ile Lys Ser Met Gln Ala 
225                 230                 235                 240 


Val Glu Asp Cys Gly Gln Glu Asn His Gln Ala Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Asp Asp Leu Ser Ile Val Cys Phe Thr Ser Gly Thr Thr Gly Asn 
            260                 265                 270         


Pro Lys Gly Ala Met Leu Thr His Gly Asn Val Val Ala Asp Phe Ser 
        275                 280                 285             


Gly Phe Leu Lys Val Thr Glu Ser Gln Trp Ala Pro Thr Cys Ala Asp 
    290                 295                 300                 


Val His Ile Ser Tyr Leu Pro Leu Ala His Met Phe Glu Arg Met Val 
305                 310                 315                 320 


Gln Ser Val Val Tyr Cys His Gly Gly Arg Val Gly Phe Phe Gln Gly 
                325                 330                 335     


Asp Ile Arg Leu Leu Ser Asp Asp Met Lys Ala Leu Cys Pro Thr Ile 
            340                 345                 350         


Phe Pro Val Val Pro Arg Leu Leu Asn Arg Met Tyr Asp Lys Ile Phe 
        355                 360                 365             


Ser Gln Ala Asn Thr Pro Leu Lys Arg Trp Leu Leu Glu Phe Ala Ala 
    370                 375                 380                 


Lys Arg Lys Gln Ala Glu Val Arg Ser Gly Ile Ile Arg Asn Asp Ser 
385                 390                 395                 400 


Ile Trp Asp Glu Leu Phe Phe Asn Lys Ile Gln Ala Ser Leu Gly Gly 
                405                 410                 415     


Cys Val Arg Met Ile Val Thr Gly Ala Ala Pro Ala Ser Pro Thr Val 
            420                 425                 430         


Leu Gly Phe Leu Arg Ala Ala Leu Gly Cys Gln Val Tyr Glu Gly Tyr 
        435                 440                 445             


Gly Gln Thr Glu Cys Thr Ala Gly Cys Thr Phe Thr Thr Pro Gly Asp 
    450                 455                 460                 


Trp Thr Ser Gly His Val Gly Ala Pro Leu Pro Cys Asn His Ile Lys 
465                 470                 475                 480 


Leu Val Asp Val Glu Glu Leu Asn Tyr Trp Ala Cys Lys Gly Glu Gly 
                485                 490                 495     


Glu Ile Cys Val Arg Gly Pro Asn Val Phe Lys Gly Tyr Leu Lys Asp 
            500                 505                 510         


Pro Asp Arg Thr Lys Glu Ala Leu Asp Ser Asp Gly Trp Leu His Thr 
        515                 520                 525             


Gly Asp Ile Gly Lys Trp Leu Pro Ala Gly Thr Leu Lys Ile Ile Asp 
    530                 535                 540                 


Arg Lys Lys His Ile Phe Lys Leu Ala Gln Gly Glu Tyr Val Ala Pro 
545                 550                 555                 560 


Glu Lys Ile Glu Asn Ile Tyr Ile Arg Ser Gln Pro Val Ala Gln Ile 
                565                 570                 575     


Tyr Val His Gly Asp Ser Leu Lys Ala Phe Leu Val Gly Ile Val Val 
            580                 585                 590         


Pro Asp Pro Glu Val Met Pro Ser Trp Ala Gln Lys Arg Gly Ile Glu 
        595                 600                 605             


Gly Thr Tyr Ala Asp Leu Cys Thr Asn Lys Asp Leu Lys Lys Ala Ile 
    610                 615                 620                 


Leu Glu Asp Met Val Arg Leu Gly Lys Glu Ser Gly Leu His Ser Phe 
625                 630                 635                 640 


Glu Gln Val Lys Ala Ile His Ile His Ser Asp Met Phe Ser Val Gln 
                645                 650                 655     


Asn Gly Leu Leu Thr Pro Thr Leu Lys Ala Lys Arg Pro Glu Leu Arg 
            660                 665                 670         


Glu Tyr Phe Lys Lys Gln Ile Glu Glu Leu Tyr Ser Ile Ser Met 
        675                 680                 685         


<210>  5
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gln Thr Gln Glu Ile Leu Arg Ile Leu Arg Leu Pro Glu Leu Gly 
1               5                   10                  15      


Asp Leu Gly Gln Phe Phe Arg Ser Leu Ser Ala Thr Thr Leu Val Ser 
            20                  25                  30          


Met Gly Ala Leu Ala Ala Ile Leu Ala Tyr Trp Phe Thr His Arg Pro 
        35                  40                  45              


Lys Ala Leu Gln Pro Pro Cys Asn Leu Leu Met Gln Ser Glu Glu Val 
    50                  55                  60                  


Glu Asp Ser Gly Gly Ala Arg Arg Ser Val Ile Gly Ser Gly Pro Gln 
65                  70                  75                  80  


Leu Leu Thr His Tyr Tyr Asp Asp Ala Arg Thr Met Tyr Gln Val Phe 
                85                  90                  95      


Arg Arg Gly Leu Ser Ile Ser Gly Asn Gly Pro Cys Leu Gly Phe Arg 
            100                 105                 110         


Lys Pro Lys Gln Pro Tyr Gln Trp Leu Ser Tyr Gln Glu Val Ala Asp 
        115                 120                 125             


Arg Ala Glu Phe Leu Gly Ser Gly Leu Leu Gln His Asn Cys Lys Ala 
    130                 135                 140                 


Cys Thr Asp Gln Phe Ile Gly Val Phe Ala Gln Asn Arg Pro Glu Trp 
145                 150                 155                 160 


Ile Ile Val Glu Leu Ala Cys Tyr Thr Tyr Ser Met Val Val Val Pro 
                165                 170                 175     


Leu Tyr Asp Thr Leu Gly Pro Gly Ala Ile Arg Tyr Ile Ile Asn Thr 
            180                 185                 190         


Ala Asp Ile Ser Thr Val Ile Val Asp Lys Pro Gln Lys Ala Val Leu 
        195                 200                 205             


Leu Leu Glu His Val Glu Arg Lys Glu Thr Pro Gly Leu Lys Leu Ile 
    210                 215                 220                 


Ile Leu Met Asp Pro Phe Glu Glu Ala Leu Lys Glu Arg Gly Gln Lys 
225                 230                 235                 240 


Cys Gly Val Val Ile Lys Ser Met Gln Ala Val Glu Asp Cys Gly Gln 
                245                 250                 255     


Glu Asn His Gln Ala Pro Val Pro Pro Gln Pro Asp Asp Leu Ser Ile 
            260                 265                 270         


Val Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Leu 
        275                 280                 285             


Thr His Gly Asn Val Val Ala Asp Phe Ser Gly Phe Leu Lys Val Thr 
    290                 295                 300                 


Glu Ser Gln Trp Ala Pro Thr Cys Ala Asp Val His Ile Ser Tyr Leu 
305                 310                 315                 320 


Pro Leu Ala His Met Phe Glu Arg Met Val Gln Ser Val Val Tyr Cys 
                325                 330                 335     


His Gly Gly Arg Val Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Ser 
            340                 345                 350         


Asp Asp Met Lys Ala Leu Cys Pro Thr Ile Phe Pro Val Val Pro Arg 
        355                 360                 365             


Leu Leu Asn Arg Met Tyr Asp Lys Ile Phe Ser Gln Ala Asn Thr Pro 
    370                 375                 380                 


Leu Lys Arg Trp Leu Leu Glu Phe Ala Ala Lys Arg Lys Gln Ala Glu 
385                 390                 395                 400 


Val Arg Ser Gly Ile Ile Arg Asn Asp Ser Ile Trp Asp Glu Leu Phe 
                405                 410                 415     


Phe Asn Lys Ile Gln Ala Ser Leu Gly Gly Cys Val Arg Met Ile Val 
            420                 425                 430         


Thr Gly Ala Ala Pro Ala Ser Pro Thr Val Leu Gly Phe Leu Arg Ala 
        435                 440                 445             


Ala Leu Gly Cys Gln Val Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr 
    450                 455                 460                 


Ala Gly Cys Thr Phe Thr Thr Pro Gly Asp Trp Thr Ser Gly His Val 
465                 470                 475                 480 


Gly Ala Pro Leu Pro Cys Asn His Ile Lys Leu Val Asp Val Glu Glu 
                485                 490                 495     


Leu Asn Tyr Trp Ala Cys Lys Gly Glu Gly Glu Ile Cys Val Arg Gly 
            500                 505                 510         


Pro Asn Val Phe Lys Gly Tyr Leu Lys Asp Pro Asp Arg Thr Lys Glu 
        515                 520                 525             


Ala Leu Asp Ser Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp 
    530                 535                 540                 


Leu Pro Ala Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe 
545                 550                 555                 560 


Lys Leu Ala Gln Gly Glu Tyr Val Ala Pro Glu Lys Ile Glu Asn Ile 
                565                 570                 575     


Tyr Ile Arg Ser Gln Pro Val Ala Gln Ile Tyr Val His Gly Asp Ser 
            580                 585                 590         


Leu Lys Ala Phe Leu Val Gly Ile Val Val Pro Asp Pro Glu Val Met 
        595                 600                 605             


Pro Ser Trp Ala Gln Lys Arg Gly Ile Glu Gly Thr Tyr Ala Asp Leu 
    610                 615                 620                 


Cys Thr Asn Lys Asp Leu Lys Lys Ala Ile Leu Glu Asp Met Val Arg 
625                 630                 635                 640 


Leu Gly Lys Glu Ser Gly Leu His Ser Phe Glu Gln Val Lys Ala Ile 
                645                 650                 655     


His Ile His Ser Asp Met Phe Ser Val Gln Asn Gly Leu Leu Thr Pro 
            660                 665                 670         


Thr Leu Lys Ala Lys Arg Pro Glu Leu Arg Glu Tyr Phe Lys Lys Gln 
        675                 680                 685             


Ile Glu Glu Leu Tyr Ser Ile Ser Met 
    690                 695         


<210>  6
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Glu Phe Val Leu Ser Leu Leu Glu Lys Met Gln Thr Gln Glu 
1               5                   10                  15      


Ile Leu Arg Ile Leu Arg Leu Pro Glu Leu Gly Asp Leu Gly Gln Phe 
            20                  25                  30          


Phe Arg Ser Leu Ser Ala Thr Thr Leu Val Ser Met Gly Ala Leu Ala 
        35                  40                  45              


Ala Ile Leu Ala Tyr Trp Phe Thr His Arg Pro Lys Ala Leu Gln Pro 
    50                  55                  60                  


Pro Cys Asn Leu Leu Met Gln Ser Glu Glu Val Glu Asp Ser Gly Gly 
65                  70                  75                  80  


Ala Arg Arg Ser Val Ile Gly Ser Gly Pro Gln Leu Leu Thr His Tyr 
                85                  90                  95      


Tyr Asp Asp Ala Arg Thr Met Tyr Gln Val Phe Arg Arg Gly Leu Ser 
            100                 105                 110         


Ile Ser Gly Asn Gly Pro Cys Leu Gly Phe Arg Lys Pro Lys Gln Pro 
        115                 120                 125             


Tyr Gln Trp Leu Ser Tyr Gln Glu Val Ala Asp Arg Ala Glu Phe Leu 
    130                 135                 140                 


Gly Ser Gly Leu Leu Gln His Asn Cys Lys Ala Cys Thr Asp Gln Phe 
145                 150                 155                 160 


Ile Gly Val Phe Ala Gln Asn Arg Pro Glu Trp Ile Ile Val Glu Leu 
                165                 170                 175     


Ala Cys Tyr Thr Tyr Ser Met Val Val Val Pro Leu Tyr Asp Thr Leu 
            180                 185                 190         


Gly Pro Gly Ala Ile Arg Tyr Ile Ile Asn Thr Ala Asp Ile Ser Thr 
        195                 200                 205             


Val Ile Val Asp Lys Pro Gln Lys Ala Val Leu Leu Leu Glu His Val 
    210                 215                 220                 


Glu Arg Lys Glu Thr Pro Gly Leu Lys Leu Ile Ile Leu Met Asp Pro 
225                 230                 235                 240 


Phe Glu Glu Ala Leu Lys Glu Arg Gly Gln Lys Cys Gly Val Val Ile 
                245                 250                 255     


Lys Ser Met Gln Ala Val Glu Asp Cys Gly Gln Glu Asn His Gln Ala 
            260                 265                 270         


Pro Val Pro Pro Gln Pro Asp Asp Leu Ser Ile Val Cys Phe Thr Ser 
        275                 280                 285             


Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Leu Thr His Gly Asn Val 
    290                 295                 300                 


Val Ala Asp Phe Ser Gly Phe Leu Lys Val Thr Glu Lys Val Ile Phe 
305                 310                 315                 320 


Pro Arg Gln Asp Asp Val Leu Ile Ser Phe Leu Pro Leu Ala His Met 
                325                 330                 335     


Phe Glu Arg Val Ile Gln Ser Val Val Tyr Cys His Gly Gly Arg Val 
            340                 345                 350         


Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Ser Asp Asp Met Lys Ala 
        355                 360                 365             


Leu Cys Pro Thr Ile Phe Pro Val Val Pro Arg Leu Leu Asn Arg Met 
    370                 375                 380                 


Tyr Asp Lys Ile Phe Ser Gln Ala Asn Thr Pro Leu Lys Arg Trp Leu 
385                 390                 395                 400 


Leu Glu Phe Ala Ala Lys Arg Lys Gln Ala Glu Val Arg Ser Gly Ile 
                405                 410                 415     


Ile Arg Asn Asp Ser Ile Trp Asp Glu Leu Phe Phe Asn Lys Ile Gln 
            420                 425                 430         


Ala Ser Leu Gly Gly Cys Val Arg Met Ile Val Thr Gly Ala Ala Pro 
        435                 440                 445             


Ala Ser Pro Thr Val Leu Gly Phe Leu Arg Ala Ala Leu Gly Cys Gln 
    450                 455                 460                 


Val Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr Ala Gly Cys Thr Phe 
465                 470                 475                 480 


Thr Thr Pro Gly Asp Trp Thr Ser Gly His Val Gly Ala Pro Leu Pro 
                485                 490                 495     


Cys Asn His Ile Lys Leu Val Asp Val Glu Glu Leu Asn Tyr Trp Ala 
            500                 505                 510         


Cys Lys Gly Glu Gly Glu Ile Cys Val Arg Gly Pro Asn Val Phe Lys 
        515                 520                 525             


Gly Tyr Leu Lys Asp Pro Asp Arg Thr Lys Glu Ala Leu Asp Ser Asp 
    530                 535                 540                 


Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp Leu Pro Ala Gly Thr 
545                 550                 555                 560 


Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe Lys Leu Ala Gln Gly 
                565                 570                 575     


Glu Tyr Val Ala Pro Glu Lys Ile Glu Asn Ile Tyr Ile Arg Ser Gln 
            580                 585                 590         


Pro Val Ala Gln Ile Tyr Val His Gly Asp Ser Leu Lys Ala Phe Leu 
        595                 600                 605             


Val Gly Ile Val Val Pro Asp Pro Glu Val Met Pro Ser Trp Ala Gln 
    610                 615                 620                 


Lys Arg Gly Ile Glu Gly Thr Tyr Ala Asp Leu Cys Thr Asn Lys Asp 
625                 630                 635                 640 


Leu Lys Lys Ala Ile Leu Glu Asp Met Val Arg Leu Gly Lys Glu Ser 
                645                 650                 655     


Gly Leu His Ser Phe Glu Gln Val Lys Ala Ile His Ile His Ser Asp 
            660                 665                 670         


Met Phe Ser Val Gln Asn Gly Leu Leu Thr Pro Thr Leu Lys Ala Lys 
        675                 680                 685             


Arg Pro Glu Leu Arg Glu Tyr Phe Lys Lys Gln Ile Glu Glu Leu Tyr 
    690                 695                 700                 


Ser Ile Ser Met 
705             


<210>  7
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gln Thr Gln Glu Ile Leu Arg Ile Leu Arg Leu Pro Glu Leu Gly 
1               5                   10                  15      


Asp Leu Gly Gln Phe Phe Arg Ser Leu Ser Ala Thr Thr Leu Asp Ser 
            20                  25                  30          


Gly Gly Ala Arg Arg Ser Val Ile Gly Ser Gly Pro Gln Leu Leu Thr 
        35                  40                  45              


His Tyr Tyr Asp Asp Ala Arg Thr Met Tyr Gln Val Phe Arg Arg Gly 
    50                  55                  60                  


Leu Ser Ile Ser Gly Asn Gly Pro Cys Leu Gly Phe Arg Lys Pro Lys 
65                  70                  75                  80  


Gln Pro Tyr Gln Trp Leu Ser Tyr Gln Glu Val Ala Asp Arg Ala Glu 
                85                  90                  95      


Phe Leu Gly Ser Gly Leu Leu Gln His Asn Cys Lys Ala Cys Thr Asp 
            100                 105                 110         


Gln Phe Ile Gly Val Phe Ala Gln Asn Arg Pro Glu Trp Ile Ile Val 
        115                 120                 125             


Glu Leu Ala Cys Tyr Thr Tyr Ser Met Val Val Val Pro Leu Tyr Asp 
    130                 135                 140                 


Thr Leu Gly Pro Gly Ala Ile Arg Tyr Ile Ile Asn Thr Ala Asp Ile 
145                 150                 155                 160 


Ser Thr Val Ile Val Asp Lys Pro Gln Lys Ala Val Leu Leu Leu Glu 
                165                 170                 175     


His Val Glu Arg Lys Glu Thr Pro Gly Leu Lys Leu Ile Ile Leu Met 
            180                 185                 190         


Asp Pro Phe Glu Glu Ala Leu Lys Glu Arg Gly Gln Lys Cys Gly Val 
        195                 200                 205             


Val Ile Lys Ser Met Gln Ala Val Glu Asp Cys Gly Gln Glu Asn His 
    210                 215                 220                 


Gln Ala Pro Val Pro Pro Gln Pro Asp Asp Leu Ser Ile Val Cys Phe 
225                 230                 235                 240 


Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Leu Thr His Gly 
                245                 250                 255     


Asn Val Val Ala Asp Phe Ser Gly Phe Leu Lys Val Thr Glu Gly Asp 
            260                 265                 270         


Ile Arg Leu Leu Ser Asp Asp Met Lys Ala Leu Cys Pro Thr Ile Phe 
        275                 280                 285             


Pro Val Val Pro Arg Leu Leu Asn Arg Met Tyr Asp Lys Ile Phe Ser 
    290                 295                 300                 


Gln Ala Asn Thr Pro Leu Lys Arg Trp Leu Leu Glu Phe Ala Ala Lys 
305                 310                 315                 320 


Arg Lys Gln Ala Glu Val Arg Ser Gly Ile Ile Arg Asn Asp Ser Ile 
                325                 330                 335     


Trp Asp Glu Leu Phe Phe Asn Lys Ile Gln Ala Ser Leu Gly Gly Cys 
            340                 345                 350         


Val Arg Met Ile Val Thr Gly Ala Ala Pro Ala Ser Pro Thr Val Leu 
        355                 360                 365             


Gly Phe Leu Arg Ala Ala Leu Gly Cys Gln Val Tyr Glu Gly Tyr Gly 
    370                 375                 380                 


Gln Thr Glu Cys Thr Ala Gly Cys Thr Phe Thr Thr Pro Gly Asp Trp 
385                 390                 395                 400 


Thr Ser Gly His Val Gly Ala Pro Leu Pro Cys Asn His Ile Lys Leu 
                405                 410                 415     


Val Asp Val Glu Glu Leu Asn Tyr Trp Ala Cys Lys Gly Glu Gly Glu 
            420                 425                 430         


Ile Cys Val Arg Gly Pro Asn Val Phe Lys Gly Tyr Leu Lys Asp Pro 
        435                 440                 445             


Asp Arg Thr Lys Glu Ala Leu Asp Ser Asp Gly Trp Leu His Thr Gly 
    450                 455                 460                 


Asp Ile Gly Lys Trp Leu Pro Ala Gly Thr Leu Lys Ile Ile Asp Arg 
465                 470                 475                 480 


Lys Lys His Ile Phe Lys Leu Ala Gln Gly Glu Tyr Val Ala Pro Glu 
                485                 490                 495     


Lys Ile Glu Asn Ile Tyr Ile Arg Ser Gln Pro Val Ala Gln Ile Tyr 
            500                 505                 510         


Val His Gly Asp Ser Leu Lys Ala Phe Leu Val Gly Ile Val Val Pro 
        515                 520                 525             


Asp Pro Glu Val Met Pro Ser Trp Ala Gln Lys Arg Gly Ile Glu Gly 
    530                 535                 540                 


Thr Tyr Ala Asp Leu Cys Thr Asn Lys Asp Leu Lys Lys Ala Ile Leu 
545                 550                 555                 560 


Glu Asp Met Val Arg Leu Gly Lys Glu Ser Gly Leu His Ser Phe Glu 
                565                 570                 575     


Gln Val Lys Ala Ile His Ile His Ser Asp Met Phe Ser Val Gln Asn 
            580                 585                 590         


Gly Leu Leu Thr Pro Thr Leu Lys Ala Lys Arg Pro Glu Leu Arg Glu 
        595                 600                 605             


Tyr Phe Lys Lys Gln Ile Glu Glu Leu Tyr Ser Ile Ser Met 
    610                 615                 620         


<210>  8
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Thr Phe Phe Leu Val Ser Gly Gly Ser Leu Trp Leu Phe Val 
1               5                   10                  15      


Glu Phe Val Leu Ser Leu Leu Glu Lys Met Gln Thr Gln Glu Ile Leu 
            20                  25                  30          


Arg Ile Leu Arg Leu Pro Glu Leu Gly Asp Leu Gly Gln Phe Phe Arg 
        35                  40                  45              


Ser Leu Ser Ala Thr Thr Leu Val Ser Met Gly Ala Leu Ala Ala Ile 
    50                  55                  60                  


Leu Ala Tyr Trp Phe Thr His Arg Pro Lys Ala Leu Gln Pro Pro Cys 
65                  70                  75                  80  


Asn Leu Leu Met Gln Ser Glu Glu Val Glu Asp Ser Gly Gly Ala Arg 
                85                  90                  95      


Arg Ser Val Ile Gly Ser Gly Pro Gln Leu Leu Thr His Tyr Tyr Asp 
            100                 105                 110         


Asp Ala Arg Thr Met Tyr Gln Val Phe Arg Arg Gly Leu Ser Ile Ser 
        115                 120                 125             


Gly Asn Gly Pro Cys Leu Gly Phe Arg Lys Pro Lys Gln Pro Tyr Gln 
    130                 135                 140                 


Trp Leu Ser Tyr Gln Glu Val Ala Asp Arg Ala Glu Phe Leu Gly Ser 
145                 150                 155                 160 


Gly Leu Leu Gln His Asn Cys Lys Ala Cys Thr Asp Gln Phe Ile Gly 
                165                 170                 175     


Val Phe Ala Gln Asn Arg Pro Glu Trp Ile Ile Val Glu Leu Ala Cys 
            180                 185                 190         


Tyr Thr Tyr Ser Met Val Val Val Pro Leu Tyr Asp Thr Leu Gly Pro 
        195                 200                 205             


Gly Ala Ile Arg Tyr Ile Ile Asn Thr Ala Asp Ile Ser Thr Val Ile 
    210                 215                 220                 


Val Asp Lys Pro Gln Lys Ala Val Leu Leu Leu Glu His Val Glu Arg 
225                 230                 235                 240 


Lys Glu Thr Pro Gly Leu Lys Leu Ile Ile Leu Met Asp Pro Phe Glu 
                245                 250                 255     


Glu Ala Leu Lys Glu Arg Gly Gln Lys Cys Gly Val Val Ile Lys Ser 
            260                 265                 270         


Met Gln Ala Val Glu Asp Cys Gly Gln Glu Asn His Gln Ala Pro Val 
        275                 280                 285             


Pro Pro Gln Pro Asp Asp Leu Ser Ile Val Cys Phe Thr Ser Gly Thr 
    290                 295                 300                 


Thr Gly Asn Pro Lys Gly Ala Met Leu Thr His Gly Asn Val Val Ala 
305                 310                 315                 320 


Asp Phe Ser Gly Phe Leu Lys Val Thr Glu Ser Gln Trp Ala Pro Thr 
                325                 330                 335     


Cys Ala Asp Val His Ile Ser Tyr Leu Pro Leu Ala His Met Phe Glu 
            340                 345                 350         


Arg Met Val Gln Ser Val Val Tyr Cys His Gly Gly Arg Val Gly Phe 
        355                 360                 365             


Phe Gln Gly Asp Ile Arg Leu Leu Ser Asp Asp Met Lys Ala Leu Cys 
    370                 375                 380                 


Pro Thr Ile Phe Pro Val Val Pro Arg Leu Leu Asn Arg Met Tyr Asp 
385                 390                 395                 400 


Lys Ile Phe Ser Gln Ala Asn Thr Pro Leu Lys Arg Trp Leu Leu Glu 
                405                 410                 415     


Phe Ala Ala Lys Arg Lys Gln Ala Glu Val Arg Ser Gly Ile Ile Arg 
            420                 425                 430         


Asn Asp Ser Ile Trp Asp Glu Leu Phe Phe Asn Lys Ile Gln Ala Ser 
        435                 440                 445             


Leu Gly Gly Cys Val Arg Met Ile Val Thr Gly Ala Ala Pro Ala Ser 
    450                 455                 460                 


Pro Thr Val Leu Gly Phe Leu Arg Ala Ala Leu Gly Cys Gln Val Tyr 
465                 470                 475                 480 


Glu Gly Tyr Gly Gln Thr Glu Cys Thr Ala Gly Cys Thr Phe Thr Thr 
                485                 490                 495     


Pro Gly Asp Trp Thr Ser Gly His Val Gly Ala Pro Leu Pro Cys Asn 
            500                 505                 510         


His Ile Lys Leu Val Asp Val Glu Glu Leu Asn Tyr Trp Ala Cys Lys 
        515                 520                 525             


Gly Glu Gly Glu Ile Cys Val Arg Gly Pro Asn Val Phe Lys Gly Tyr 
    530                 535                 540                 


Leu Lys Asp Pro Asp Arg Thr Lys Glu Ala Leu Asp Ser Asp Gly Trp 
545                 550                 555                 560 


Leu His Thr Gly Asp Ile Gly Lys Trp Leu Pro Ala Gly Thr Leu Lys 
                565                 570                 575     


Ile Ile Asp Arg Lys Lys His Ile Phe Lys Leu Ala Gln Gly Glu Tyr 
            580                 585                 590         


Val Ala Pro Glu Lys Ile Glu Asn Ile Tyr Ile Arg Ser Gln Pro Val 
        595                 600                 605             


Ala Gln Ile Tyr Val His Gly Asp Ser Leu Lys Ala Phe Leu Val Gly 
    610                 615                 620                 


Ile Val Val Pro Asp Pro Glu Val Met Pro Ser Trp Ala Gln Lys Arg 
625                 630                 635                 640 


Gly Ile Glu Gly Thr Tyr Ala Asp Leu Cys Thr Asn Lys Asp Leu Lys 
                645                 650                 655     


Lys Ala Ile Leu Glu Asp Met Val Arg Leu Gly Lys Glu Ser Gly Leu 
            660                 665                 670         


His Ser Phe Glu Gln Val Lys Ala Ile His Ile His Ser Asp Met Phe 
        675                 680                 685             


Ser Val Gln Asn Gly Leu Leu Thr Pro Thr Leu Lys Ala Lys Arg Pro 
    690                 695                 700                 


Glu Leu Arg Glu Tyr Phe Lys Lys Gln Ile Glu Glu Leu Tyr Ser Ile 
705                 710                 715                 720 


Ser Met 
        


<210>  9
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr Ser Asp Ser 
        115                 120                 125             


Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu Ile Val Phe 
    130                 135                 140                 


Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala Thr Asn Arg 
145                 150                 155                 160 


Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg Gly Ser Cys 
                165                 170                 175     


Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn Val Phe Pro 
            180                 185                 190         


Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu Thr Leu Lys 
        195                 200                 205             


Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn Arg Glu Phe 
    210                 215                 220                 


Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg Leu Ile Glu 
225                 230                 235                 240 


Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn Ile Arg Ile 
                245                 250                 255     


Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys Cys Ser Val 
            260                 265                 270         


Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp Trp Arg Lys 
        275                 280                 285             


Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln Leu Val Ser 
    290                 295                 300                 


Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro Ile Met Ser 
305                 310                 315                 320 


Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp His Ser Asp 
                325                 330                 335     


Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser Cys Gln Met 
        355                 360                 365             


Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr Gly Tyr Pro 
    370                 375                 380                 


Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu Glu Thr Ser 
385                 390                 395                 400 


Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro Glu Val Arg 
                405                 410                 415     


Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val Glu Glu Gly 
            420                 425                 430         


Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn Arg Cys Cys 
        435                 440                 445             


Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys Ala His Gly 
    450                 455                 460                 


Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr Ala Cys Arg 
465                 470                 475                 480 


Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr Gly Ala Ser 
                485                 490                 495     


Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His Ser Cys Gln 
            500                 505                 510         


Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr His Glu Gln 
        515                 520                 525             


Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala Pro Gly Ile 
    530                 535                 540                 


Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly Asn Cys Gly 
545                 550                 555                 560 


Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg Asp Ala Lys 
                565                 570                 575     


Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro Val Ile Gly 
            580                 585                 590         


Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln Gln Gly Gly 
        595                 600                 605             


Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp Asp Met Pro 
    610                 615                 620                 


Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp Gly Lys Ile 
625                 630                 635                 640 


Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly Val His Glu 
                645                 650                 655     


Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn Arg Lys Asn 
            660                 665                 670         


Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp Lys Phe Gly 
        675                 680                 685             


Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala Gly Lys Glu 
    690                 695                 700                 


Ala Arg Gln Glu Ala Ala Glu Ser Asn Arg Glu Arg Gly Gln Gly Gln 
705                 710                 715                 720 


Glu Pro Val Gly Ser Gln Glu His Ala Ser Thr Ala Ser Leu Thr Leu 
                725                 730                 735     


Ile 
    


<210>  10
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr Ser Asp Ser 
        115                 120                 125             


Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu Ile Val Phe 
    130                 135                 140                 


Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala Thr Asn Arg 
145                 150                 155                 160 


Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg Gly Ser Cys 
                165                 170                 175     


Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn Val Phe Pro 
            180                 185                 190         


Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu Thr Leu Lys 
        195                 200                 205             


Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn Arg Glu Phe 
    210                 215                 220                 


Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg Leu Ile Glu 
225                 230                 235                 240 


Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn Ile Arg Ile 
                245                 250                 255     


Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys Cys Ser Val 
            260                 265                 270         


Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp Trp Arg Lys 
        275                 280                 285             


Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln Leu Val Ser 
    290                 295                 300                 


Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro Ile Met Ser 
305                 310                 315                 320 


Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp His Ser Asp 
                325                 330                 335     


Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser Cys Gln Met 
        355                 360                 365             


Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr Gly Tyr Pro 
    370                 375                 380                 


Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu Glu Thr Ser 
385                 390                 395                 400 


Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro Glu Val Arg 
                405                 410                 415     


Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val Glu Glu Gly 
            420                 425                 430         


Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn Arg Cys Cys 
        435                 440                 445             


Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys Ala His Gly 
    450                 455                 460                 


Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr Ala Cys Arg 
465                 470                 475                 480 


Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr Gly Ala Ser 
                485                 490                 495     


Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His Ser Cys Gln 
            500                 505                 510         


Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr His Glu Gln 
        515                 520                 525             


Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala Pro Gly Ile 
    530                 535                 540                 


Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly Asn Cys Gly 
545                 550                 555                 560 


Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg Asp Ala Lys 
                565                 570                 575     


Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro Val Ile Gly 
            580                 585                 590         


Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln Gln Gly Gly 
        595                 600                 605             


Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp Asp Met Pro 
    610                 615                 620                 


Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp Gly Lys Ile 
625                 630                 635                 640 


Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly Val His Glu 
                645                 650                 655     


Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn Arg Lys Asn 
            660                 665                 670         


Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp Lys Phe Gly 
        675                 680                 685             


Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala Glu Ala Arg 
    690                 695                 700                 


Gln Glu Ala Ala Glu Ser Asn Arg Glu Arg Gly Gln Gly Gln Glu Pro 
705                 710                 715                 720 


Val Gly Ser Gln Glu His Ala Ser Thr Ala Ser Leu Thr Leu Ile 
                725                 730                 735 


<210>  11
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Asp Asn Gln Gly Leu Thr Ile Gly Ile Leu Val Thr Ile Leu Cys Leu 
705                 710                 715                 720 


Leu Ala Ala Gly Phe Val Val Tyr Leu Lys Arg Lys Thr Leu Ile Arg 
                725                 730                 735     


Leu Leu Phe Thr Asn Lys Lys Thr Thr Ile Glu Lys Leu Arg Cys Val 
            740                 745                 750         


Arg Pro Ser Arg Pro Pro Arg Gly Phe Gln Pro Cys Gln Ala His Leu 
        755                 760                 765             


Gly His Leu Gly Lys Gly Leu Met Arg Lys Pro Pro Asp Ser Tyr Pro 
    770                 775                 780                 


Pro Lys Asp Asn Pro Arg Arg Leu Leu Gln Cys Gln Asn Val Asp Ile 
785                 790                 795                 800 


Ser Arg Pro Leu Asn Gly Leu Asn Val Pro Gln Pro Gln Ser Thr Gln 
                805                 810                 815     


Arg Val Leu Pro Pro Leu His Arg Ala Pro Arg Ala Pro Ser Val Pro 
            820                 825                 830         


Ala Arg Pro Leu Pro Ala Lys Pro Ala Leu Arg Gln Ala Gln Gly Thr 
        835                 840                 845             


Cys Lys Pro Asn Pro Pro Gln Lys Pro Leu Pro Ala Asp Pro Leu Ala 
    850                 855                 860                 


Arg Thr Thr Arg Leu Thr His Ala Leu Ala Arg Thr Pro Gly Gln Trp 
865                 870                 875                 880 


Glu Thr Gly Leu Arg Leu Ala Pro Leu Arg Pro Ala Pro Gln Tyr Pro 
                885                 890                 895     


His Gln Val Pro Arg Ser Thr His Thr Ala Tyr Ile Lys 
            900                 905                 


<210>  12
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Glu Ala Arg Gln Glu Ala Ala Glu Ser Asn Arg Glu Arg Gly Gln Gly 
705                 710                 715                 720 


Gln Glu Pro Val Gly Ser Gln Glu His Ala Ser Thr Ala Ser Leu Thr 
                725                 730                 735     


Leu Ile 
        


<210>  13
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
1               5                   10                  15      


Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
            20                  25                  30          


Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
        35                  40                  45              


Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
    50                  55                  60                  


His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
65                  70                  75                  80  


Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                85                  90                  95      


Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
            100                 105                 110         


Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
        115                 120                 125             


Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
    130                 135                 140                 


Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
145                 150                 155                 160 


Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                165                 170                 175     


Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
            180                 185                 190         


Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
        195                 200                 205             


Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
    210                 215                 220                 


Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
225                 230                 235                 240 


Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                245                 250                 255     


Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
            260                 265                 270         


Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
        275                 280                 285             


Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
    290                 295                 300                 


Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
305                 310                 315                 320 


Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                325                 330                 335     


Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
            340                 345                 350         


Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
        355                 360                 365             


Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
    370                 375                 380                 


Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
385                 390                 395                 400 


Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                405                 410                 415     


Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
            420                 425                 430         


Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
        435                 440                 445             


Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
    450                 455                 460                 


Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
465                 470                 475                 480 


Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                485                 490                 495     


Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
            500                 505                 510         


Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
        515                 520                 525             


Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
    530                 535                 540                 


Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                565                 570                 575     


Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
            580                 585                 590         


Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
        595                 600                 605             


Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
    610                 615                 620                 


Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
625                 630                 635                 640 


Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                645                 650                 655     


Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
            660                 665                 670         


Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
        675                 680                 685             


Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
    690                 695                 700                 


Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
705                 710                 715                 720 


Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                725                 730                 735     


Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
            740                 745                 750         


Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
        755                 760                 765             


Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
    770                 775                 780                 


Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
785                 790                 795                 800 


Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                805                 810                 815     


Val Asp Ser Lys Glu Thr Glu Cys 
            820                 


<210>  14
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  15
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  16
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  17
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  18
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  19
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  20
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  21
<211>  1077
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Arg Leu Phe Ser Pro Arg Pro Pro Pro Ser Glu Asp Leu Phe 
1               5                   10                  15      


Tyr Glu Thr Tyr Tyr Ser Leu Ser Gln Gln Tyr Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Gly Ile Val Leu Cys Ala Leu Ala Ala Leu Leu Ala Val Ala 
        35                  40                  45              


Trp Ala Ser Gly Arg Glu Leu Thr Ser Asp Pro Ser Phe Leu Thr Thr 
    50                  55                  60                  


Val Leu Cys Ala Leu Gly Gly Phe Ser Leu Leu Leu Gly Leu Ala Ser 
65                  70                  75                  80  


Arg Glu Gln Arg Leu Gln Arg Trp Thr Arg Pro Leu Ser Gly Leu Val 
                85                  90                  95      


Trp Val Ala Leu Leu Ala Leu Gly His Ala Phe Leu Phe Thr Gly Gly 
            100                 105                 110         


Val Val Ser Ala Trp Asp Gln Val Ser Tyr Phe Leu Phe Val Ile Phe 
        115                 120                 125             


Thr Ala Tyr Ala Met Leu Pro Leu Gly Met Arg Asp Ala Ala Val Ala 
    130                 135                 140                 


Gly Leu Ala Ser Ser Leu Ser His Leu Leu Val Leu Gly Leu Tyr Leu 
145                 150                 155                 160 


Gly Pro Gln Pro Asp Ser Arg Pro Ala Leu Leu Pro Gln Leu Ala Ala 
                165                 170                 175     


Asn Ala Val Leu Phe Leu Cys Gly Asn Val Ala Gly Val Tyr His Lys 
            180                 185                 190         


Ala Leu Met Glu Arg Ala Leu Arg Ala Thr Phe Arg Glu Ala Leu Ser 
        195                 200                 205             


Ser Leu His Ser Arg Arg Arg Leu Asp Thr Glu Lys Lys His Gln Glu 
    210                 215                 220                 


His Leu Leu Leu Ser Ile Leu Pro Ala Tyr Leu Ala Arg Glu Met Lys 
225                 230                 235                 240 


Ala Glu Ile Met Ala Arg Leu Gln Ala Gly Gln Gly Ser Arg Pro Glu 
                245                 250                 255     


Ser Thr Asn Asn Phe His Ser Leu Tyr Val Lys Arg His Gln Gly Val 
            260                 265                 270         


Ser Val Leu Tyr Ala Asp Ile Val Gly Phe Thr Arg Leu Ala Ser Glu 
        275                 280                 285             


Cys Ser Pro Lys Glu Leu Val Leu Met Leu Asn Glu Leu Phe Gly Lys 
    290                 295                 300                 


Phe Asp Gln Ile Ala Lys Glu His Glu Cys Met Arg Ile Lys Ile Leu 
305                 310                 315                 320 


Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Leu Ser Leu Pro Asp 
                325                 330                 335     


His Ala Ile Asn Cys Val Arg Met Gly Leu Asp Met Cys Arg Ala Ile 
            340                 345                 350         


Arg Lys Leu Arg Ala Ala Thr Gly Val Asp Ile Asn Met Arg Val Gly 
        355                 360                 365             


Val His Ser Gly Ser Val Leu Cys Gly Val Ile Gly Leu Gln Lys Trp 
    370                 375                 380                 


Gln Tyr Asp Val Trp Ser His Asp Val Thr Leu Ala Asn His Met Glu 
385                 390                 395                 400 


Ala Gly Gly Val Pro Gly Arg Val His Ile Thr Gly Ala Thr Leu Ala 
                405                 410                 415     


Leu Leu Ala Gly Ala Tyr Ala Val Glu Asp Ala Gly Met Glu His Arg 
            420                 425                 430         


Asp Pro Tyr Leu Arg Glu Leu Gly Glu Pro Thr Tyr Leu Val Ile Asp 
        435                 440                 445             


Pro Arg Ala Glu Glu Glu Asp Glu Lys Gly Thr Ala Gly Gly Leu Leu 
    450                 455                 460                 


Ser Ser Leu Glu Gly Leu Lys Met Arg Pro Ser Leu Leu Met Thr Arg 
465                 470                 475                 480 


Tyr Leu Glu Ser Trp Gly Ala Ala Lys Pro Phe Ala His Leu Ser His 
                485                 490                 495     


Gly Asp Ser Pro Val Ser Thr Ser Thr Pro Leu Pro Glu Lys Thr Leu 
            500                 505                 510         


Ala Ser Phe Ser Thr Gln Trp Ser Leu Asp Arg Ser Arg Thr Pro Arg 
        515                 520                 525             


Gly Leu Asp Asp Glu Leu Asp Thr Gly Asp Ala Lys Phe Phe Gln Val 
    530                 535                 540                 


Ile Glu Gln Leu Asn Ser Gln Lys Gln Trp Lys Gln Ser Lys Asp Phe 
545                 550                 555                 560 


Asn Pro Leu Thr Leu Tyr Phe Arg Glu Lys Glu Met Glu Lys Glu Tyr 
                565                 570                 575     


Arg Leu Ser Ala Ile Pro Ala Phe Lys Tyr Tyr Glu Ala Cys Thr Phe 
            580                 585                 590         


Leu Val Phe Leu Ser Asn Phe Ile Ile Gln Met Leu Val Thr Asn Arg 
        595                 600                 605             


Pro Pro Ala Leu Ala Ile Thr Tyr Ser Ile Thr Phe Leu Leu Phe Leu 
    610                 615                 620                 


Leu Ile Leu Phe Val Cys Phe Ser Glu Asp Leu Met Arg Cys Val Leu 
625                 630                 635                 640 


Lys Gly Pro Lys Met Leu His Trp Leu Pro Ala Leu Ser Gly Leu Val 
                645                 650                 655     


Ala Thr Arg Pro Gly Leu Arg Ile Ala Leu Gly Thr Ala Thr Ile Leu 
            660                 665                 670         


Leu Val Phe Ala Met Ala Ile Thr Ser Leu Phe Phe Phe Pro Thr Ser 
        675                 680                 685             


Ser Asp Cys Pro Phe Gln Ala Pro Asn Val Ser Ser Met Ile Ser Asn 
    690                 695                 700                 


Leu Ser Trp Glu Leu Pro Gly Ser Leu Pro Leu Ile Ser Val Pro Tyr 
705                 710                 715                 720 


Ser Met His Cys Cys Thr Leu Gly Phe Leu Ser Cys Ser Leu Phe Leu 
                725                 730                 735     


His Met Ser Phe Glu Leu Lys Leu Leu Leu Leu Leu Leu Trp Leu Ala 
            740                 745                 750         


Ala Ser Cys Ser Leu Phe Leu His Ser His Ala Trp Leu Ser Glu Cys 
        755                 760                 765             


Leu Ile Val Arg Leu Tyr Leu Gly Pro Leu Asp Ser Arg Pro Gly Val 
    770                 775                 780                 


Leu Lys Glu Pro Lys Leu Met Gly Ala Ile Ser Phe Phe Ile Phe Phe 
785                 790                 795                 800 


Phe Thr Leu Leu Val Leu Ala Arg Gln Asn Glu Tyr Tyr Cys Arg Leu 
                805                 810                 815     


Asp Phe Leu Trp Lys Lys Lys Leu Arg Gln Glu Arg Glu Glu Thr Glu 
            820                 825                 830         


Thr Met Glu Asn Leu Thr Arg Leu Leu Leu Glu Asn Val Leu Pro Ala 
        835                 840                 845             


His Val Ala Pro Gln Phe Ile Gly Gln Asn Arg Arg Asn Glu Asp Leu 
    850                 855                 860                 


Tyr His Gln Ser Tyr Glu Cys Val Cys Val Leu Phe Ala Ser Val Pro 
865                 870                 875                 880 


Asp Phe Lys Glu Phe Tyr Ser Glu Ser Asn Ile Asn His Glu Gly Leu 
                885                 890                 895     


Glu Cys Leu Arg Leu Leu Asn Glu Ile Ile Ala Asp Phe Asp Glu Leu 
            900                 905                 910         


Leu Ser Lys Pro Lys Phe Ser Gly Val Glu Lys Ile Lys Thr Ile Gly 
        915                 920                 925             


Ser Thr Tyr Met Ala Ala Thr Gly Leu Asn Ala Thr Ser Gly Gln Asp 
    930                 935                 940                 


Ala Gln Gln Asp Ala Glu Arg Ser Cys Ser His Leu Gly Thr Met Val 
945                 950                 955                 960 


Glu Phe Ala Val Ala Leu Gly Ser Lys Leu Asp Val Ile Asn Lys His 
                965                 970                 975     


Ser Phe Asn Asn Phe Arg Leu Arg Val Gly Leu Asn His Gly Pro Val 
            980                 985                 990         


Val Ala Gly Val Ile Gly Ala Gln  Lys Pro Gln Tyr Asp  Ile Trp Gly 
        995                 1000                 1005             


Asn Thr  Val Asn Val Ala Ser  Arg Met Glu Ser Thr  Gly Val Leu 
    1010                 1015                 1020             


Gly Lys  Ile Gln Val Thr Glu  Glu Thr Ala Trp Ala  Leu Gln Ser 
    1025                 1030                 1035             


Leu Gly  Tyr Thr Cys Tyr Ser  Arg Gly Val Ile Lys  Val Lys Gly 
    1040                 1045                 1050             


Lys Gly  Gln Leu Cys Thr Tyr  Phe Leu Asn Thr Asp  Leu Thr Arg 
    1055                 1060                 1065             


Thr Gly  Pro Pro Ser Ala Thr  Leu Gly 
    1070                 1075         


<210>  22
<211>  1077
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Arg Leu Phe Ser Pro Arg Pro Pro Pro Ser Glu Asp Leu Phe 
1               5                   10                  15      


Tyr Glu Thr Tyr Tyr Ser Leu Ser Gln Gln Tyr Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Gly Ile Val Leu Cys Ala Leu Ala Ala Leu Leu Ala Val Ala 
        35                  40                  45              


Trp Ala Ser Gly Arg Glu Leu Thr Ser Asp Pro Ser Phe Leu Thr Thr 
    50                  55                  60                  


Val Leu Cys Ala Leu Gly Gly Phe Ser Leu Leu Leu Gly Leu Ala Ser 
65                  70                  75                  80  


Arg Glu Gln Arg Leu Gln Arg Trp Thr Arg Pro Leu Ser Gly Leu Val 
                85                  90                  95      


Trp Val Ala Leu Leu Ala Leu Gly His Ala Phe Leu Phe Thr Gly Gly 
            100                 105                 110         


Val Val Ser Ala Trp Asp Gln Val Ser Tyr Phe Leu Phe Val Ile Phe 
        115                 120                 125             


Thr Ala Tyr Ala Met Leu Pro Leu Gly Met Arg Asp Ala Ala Val Ala 
    130                 135                 140                 


Gly Leu Ala Ser Ser Leu Ser His Leu Leu Val Leu Gly Leu Tyr Leu 
145                 150                 155                 160 


Gly Pro Gln Pro Asp Ser Arg Pro Ala Leu Leu Pro Gln Leu Ala Ala 
                165                 170                 175     


Asn Ala Val Leu Phe Leu Cys Gly Asn Val Ala Gly Val Tyr His Lys 
            180                 185                 190         


Ala Leu Met Glu Arg Ala Leu Arg Ala Thr Phe Arg Glu Ala Leu Ser 
        195                 200                 205             


Ser Leu His Ser Arg Arg Arg Leu Asp Thr Glu Lys Lys His Gln Glu 
    210                 215                 220                 


His Leu Leu Leu Ser Ile Leu Pro Ala Tyr Leu Ala Arg Glu Met Lys 
225                 230                 235                 240 


Ala Glu Ile Met Ala Arg Leu Gln Ala Gly Gln Gly Ser Arg Pro Glu 
                245                 250                 255     


Ser Thr Asn Asn Phe His Ser Leu Tyr Val Lys Arg His Gln Gly Val 
            260                 265                 270         


Ser Val Leu Tyr Ala Asp Ile Val Gly Phe Thr Arg Leu Ala Ser Glu 
        275                 280                 285             


Cys Ser Pro Lys Glu Leu Val Leu Met Leu Asn Glu Leu Phe Gly Lys 
    290                 295                 300                 


Phe Asp Gln Ile Ala Lys Glu His Glu Cys Met Arg Ile Lys Ile Leu 
305                 310                 315                 320 


Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Leu Ser Leu Pro Asp 
                325                 330                 335     


His Ala Ile Asn Cys Val Arg Met Gly Leu Asp Met Cys Arg Ala Ile 
            340                 345                 350         


Arg Lys Leu Arg Ala Ala Thr Gly Val Asp Ile Asn Met Arg Val Gly 
        355                 360                 365             


Val His Ser Gly Ser Val Leu Cys Gly Val Ile Gly Leu Gln Lys Trp 
    370                 375                 380                 


Gln Tyr Asp Val Trp Ser His Asp Val Thr Leu Ala Asn His Met Glu 
385                 390                 395                 400 


Ala Gly Gly Val Pro Gly Arg Val His Ile Thr Gly Ala Thr Leu Ala 
                405                 410                 415     


Leu Leu Ala Gly Ala Tyr Ala Val Glu Asp Ala Gly Met Glu His Arg 
            420                 425                 430         


Asp Pro Tyr Leu Arg Glu Leu Gly Glu Pro Thr Tyr Leu Val Ile Asp 
        435                 440                 445             


Pro Arg Ala Glu Glu Glu Asp Glu Lys Gly Thr Ala Gly Gly Leu Leu 
    450                 455                 460                 


Ser Ser Leu Glu Gly Leu Lys Met Arg Pro Ser Leu Leu Met Thr Arg 
465                 470                 475                 480 


Tyr Leu Glu Ser Trp Gly Ala Ala Lys Pro Phe Ala His Leu Ser His 
                485                 490                 495     


Gly Asp Ser Pro Val Ser Thr Ser Thr Pro Leu Pro Glu Lys Thr Leu 
            500                 505                 510         


Ala Ser Phe Ser Thr Gln Trp Ser Leu Asp Arg Ser Arg Thr Pro Arg 
        515                 520                 525             


Gly Leu Asp Asp Glu Leu Asp Thr Gly Asp Ala Lys Phe Phe Gln Val 
    530                 535                 540                 


Ile Glu Gln Leu Asn Ser Gln Lys Gln Trp Lys Gln Ser Lys Asp Phe 
545                 550                 555                 560 


Asn Pro Leu Thr Leu Tyr Phe Arg Glu Lys Glu Met Glu Lys Glu Tyr 
                565                 570                 575     


Arg Leu Ser Ala Ile Pro Ala Phe Lys Tyr Tyr Glu Ala Cys Thr Phe 
            580                 585                 590         


Leu Val Phe Leu Ser Asn Phe Ile Ile Gln Met Leu Val Thr Asn Arg 
        595                 600                 605             


Pro Pro Ala Leu Ala Ile Thr Tyr Ser Ile Thr Phe Leu Leu Phe Leu 
    610                 615                 620                 


Leu Ile Leu Phe Val Cys Phe Ser Glu Asp Leu Met Arg Cys Val Leu 
625                 630                 635                 640 


Lys Gly Pro Lys Met Leu His Trp Leu Pro Ala Leu Ser Gly Leu Val 
                645                 650                 655     


Ala Thr Arg Pro Gly Leu Arg Ile Ala Leu Gly Thr Ala Thr Ile Leu 
            660                 665                 670         


Leu Val Phe Ala Met Ala Ile Thr Ser Leu Phe Phe Phe Pro Thr Ser 
        675                 680                 685             


Ser Asp Cys Pro Phe Gln Ala Pro Asn Val Ser Ser Met Ile Ser Asn 
    690                 695                 700                 


Leu Ser Trp Glu Leu Pro Gly Ser Leu Pro Leu Ile Ser Val Pro Tyr 
705                 710                 715                 720 


Ser Met His Cys Cys Thr Leu Gly Phe Leu Ser Cys Ser Leu Phe Leu 
                725                 730                 735     


His Met Ser Phe Glu Leu Lys Leu Leu Leu Leu Leu Leu Trp Leu Ala 
            740                 745                 750         


Ala Ser Cys Ser Leu Phe Leu His Ser His Ala Trp Leu Ser Glu Cys 
        755                 760                 765             


Leu Ile Val Arg Leu Tyr Leu Gly Pro Leu Asp Ser Arg Pro Gly Val 
    770                 775                 780                 


Leu Lys Glu Pro Lys Leu Met Gly Ala Ile Ser Phe Phe Ile Phe Phe 
785                 790                 795                 800 


Phe Thr Leu Leu Val Leu Ala Arg Gln Asn Glu Tyr Tyr Cys Arg Leu 
                805                 810                 815     


Asp Phe Leu Trp Lys Lys Lys Leu Arg Gln Glu Arg Glu Glu Thr Glu 
            820                 825                 830         


Thr Met Glu Asn Leu Thr Arg Leu Leu Leu Glu Asn Val Leu Pro Ala 
        835                 840                 845             


His Val Ala Pro Gln Phe Ile Gly Gln Asn Arg Arg Asn Glu Asp Leu 
    850                 855                 860                 


Tyr His Gln Ser Tyr Glu Cys Val Cys Val Leu Phe Ala Ser Val Pro 
865                 870                 875                 880 


Asp Phe Lys Glu Phe Tyr Ser Glu Ser Asn Ile Asn His Glu Gly Leu 
                885                 890                 895     


Glu Cys Leu Arg Leu Leu Asn Glu Ile Ile Ala Asp Phe Asp Glu Leu 
            900                 905                 910         


Leu Ser Lys Pro Lys Phe Ser Gly Val Glu Lys Ile Lys Thr Ile Gly 
        915                 920                 925             


Ser Thr Tyr Met Ala Ala Thr Gly Leu Asn Ala Thr Ser Gly Gln Asp 
    930                 935                 940                 


Ala Gln Gln Asp Ala Glu Arg Ser Cys Ser His Leu Gly Thr Met Val 
945                 950                 955                 960 


Glu Phe Ala Val Ala Leu Gly Ser Lys Leu Asp Val Ile Asn Lys His 
                965                 970                 975     


Ser Phe Asn Asn Phe Arg Leu Arg Val Gly Leu Asn His Gly Pro Val 
            980                 985                 990         


Val Ala Gly Val Ile Gly Ala Gln  Lys Pro Gln Tyr Asp  Ile Trp Gly 
        995                 1000                 1005             


Asn Thr  Val Asn Val Ala Ser  Arg Met Glu Ser Thr  Gly Val Leu 
    1010                 1015                 1020             


Gly Lys  Ile Gln Val Thr Glu  Glu Thr Ala Trp Ala  Leu Gln Ser 
    1025                 1030                 1035             


Leu Gly  Tyr Thr Cys Tyr Ser  Arg Gly Val Ile Lys  Val Lys Gly 
    1040                 1045                 1050             


Lys Gly  Gln Leu Cys Thr Tyr  Phe Leu Asn Thr Asp  Leu Thr Arg 
    1055                 1060                 1065             


Thr Gly  Pro Pro Ser Ala Thr  Leu Gly 
    1070                 1075         


<210>  23
<211>  1077
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Arg Leu Phe Ser Pro Arg Pro Pro Pro Ser Glu Asp Leu Phe 
1               5                   10                  15      


Tyr Glu Thr Tyr Tyr Ser Leu Ser Gln Gln Tyr Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Gly Ile Val Leu Cys Ala Leu Ala Ala Leu Leu Ala Val Ala 
        35                  40                  45              


Trp Ala Ser Gly Arg Glu Leu Thr Ser Asp Pro Ser Phe Leu Thr Thr 
    50                  55                  60                  


Val Leu Cys Ala Leu Gly Gly Phe Ser Leu Leu Leu Gly Leu Ala Ser 
65                  70                  75                  80  


Arg Glu Gln Arg Leu Gln Arg Trp Thr Arg Pro Leu Ser Gly Leu Val 
                85                  90                  95      


Trp Val Ala Leu Leu Ala Leu Gly His Ala Phe Leu Phe Thr Gly Gly 
            100                 105                 110         


Val Val Ser Ala Trp Asp Gln Val Ser Tyr Phe Leu Phe Val Ile Phe 
        115                 120                 125             


Thr Ala Tyr Ala Met Leu Pro Leu Gly Met Arg Asp Ala Ala Val Ala 
    130                 135                 140                 


Gly Leu Ala Ser Ser Leu Ser His Leu Leu Val Leu Gly Leu Tyr Leu 
145                 150                 155                 160 


Gly Pro Gln Pro Asp Ser Arg Pro Ala Leu Leu Pro Gln Leu Ala Ala 
                165                 170                 175     


Asn Ala Val Leu Phe Leu Cys Gly Asn Val Ala Gly Val Tyr His Lys 
            180                 185                 190         


Ala Leu Met Glu Arg Ala Leu Arg Ala Thr Phe Arg Glu Ala Leu Ser 
        195                 200                 205             


Ser Leu His Ser Arg Arg Arg Leu Asp Thr Glu Lys Lys His Gln Glu 
    210                 215                 220                 


His Leu Leu Leu Ser Ile Leu Pro Ala Tyr Leu Ala Arg Glu Met Lys 
225                 230                 235                 240 


Ala Glu Ile Met Ala Arg Leu Gln Ala Gly Gln Gly Ser Arg Pro Glu 
                245                 250                 255     


Ser Thr Asn Asn Phe His Ser Leu Tyr Val Lys Arg His Gln Gly Val 
            260                 265                 270         


Ser Val Leu Tyr Ala Asp Ile Val Gly Phe Thr Arg Leu Ala Ser Glu 
        275                 280                 285             


Cys Ser Pro Lys Glu Leu Val Leu Met Leu Asn Glu Leu Phe Gly Lys 
    290                 295                 300                 


Phe Asp Gln Ile Ala Lys Glu His Glu Cys Met Arg Ile Lys Ile Leu 
305                 310                 315                 320 


Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Leu Ser Leu Pro Asp 
                325                 330                 335     


His Ala Ile Asn Cys Val Arg Met Gly Leu Asp Met Cys Arg Ala Ile 
            340                 345                 350         


Arg Lys Leu Arg Ala Ala Thr Gly Val Asp Ile Asn Met Arg Val Gly 
        355                 360                 365             


Val His Ser Gly Ser Val Leu Cys Gly Val Ile Gly Leu Gln Lys Trp 
    370                 375                 380                 


Gln Tyr Asp Val Trp Ser His Asp Val Thr Leu Ala Asn His Met Glu 
385                 390                 395                 400 


Ala Gly Gly Val Pro Gly Arg Val His Ile Thr Gly Ala Thr Leu Ala 
                405                 410                 415     


Leu Leu Ala Gly Ala Tyr Ala Val Glu Asp Ala Gly Met Glu His Arg 
            420                 425                 430         


Asp Pro Tyr Leu Arg Glu Leu Gly Glu Pro Thr Tyr Leu Val Ile Asp 
        435                 440                 445             


Pro Arg Ala Glu Glu Glu Asp Glu Lys Gly Thr Ala Gly Gly Leu Leu 
    450                 455                 460                 


Ser Ser Leu Glu Gly Leu Lys Met Arg Pro Ser Leu Leu Met Thr Arg 
465                 470                 475                 480 


Tyr Leu Glu Ser Trp Gly Ala Ala Lys Pro Phe Ala His Leu Ser His 
                485                 490                 495     


Gly Asp Ser Pro Val Ser Thr Ser Thr Pro Leu Pro Glu Lys Thr Leu 
            500                 505                 510         


Ala Ser Phe Ser Thr Gln Trp Ser Leu Asp Arg Ser Arg Thr Pro Arg 
        515                 520                 525             


Gly Leu Asp Asp Glu Leu Asp Thr Gly Asp Ala Lys Phe Phe Gln Val 
    530                 535                 540                 


Ile Glu Gln Leu Asn Ser Gln Lys Gln Trp Lys Gln Ser Lys Asp Phe 
545                 550                 555                 560 


Asn Pro Leu Thr Leu Tyr Phe Arg Glu Lys Glu Met Glu Lys Glu Tyr 
                565                 570                 575     


Arg Leu Ser Ala Ile Pro Ala Phe Lys Tyr Tyr Glu Ala Cys Thr Phe 
            580                 585                 590         


Leu Val Phe Leu Ser Asn Phe Ile Ile Gln Met Leu Val Thr Asn Arg 
        595                 600                 605             


Pro Pro Ala Leu Ala Ile Thr Tyr Ser Ile Thr Phe Leu Leu Phe Leu 
    610                 615                 620                 


Leu Ile Leu Phe Val Cys Phe Ser Glu Asp Leu Met Arg Cys Val Leu 
625                 630                 635                 640 


Lys Gly Pro Lys Met Leu His Trp Leu Pro Ala Leu Ser Gly Leu Val 
                645                 650                 655     


Ala Thr Arg Pro Gly Leu Arg Ile Ala Leu Gly Thr Ala Thr Ile Leu 
            660                 665                 670         


Leu Val Phe Ala Met Ala Ile Thr Ser Leu Phe Phe Phe Pro Thr Ser 
        675                 680                 685             


Ser Asp Cys Pro Phe Gln Ala Pro Asn Val Ser Ser Met Ile Ser Asn 
    690                 695                 700                 


Leu Ser Trp Glu Leu Pro Gly Ser Leu Pro Leu Ile Ser Val Pro Tyr 
705                 710                 715                 720 


Ser Met His Cys Cys Thr Leu Gly Phe Leu Ser Cys Ser Leu Phe Leu 
                725                 730                 735     


His Met Ser Phe Glu Leu Lys Leu Leu Leu Leu Leu Leu Trp Leu Ala 
            740                 745                 750         


Ala Ser Cys Ser Leu Phe Leu His Ser His Ala Trp Leu Ser Glu Cys 
        755                 760                 765             


Leu Ile Val Arg Leu Tyr Leu Gly Pro Leu Asp Ser Arg Pro Gly Val 
    770                 775                 780                 


Leu Lys Glu Pro Lys Leu Met Gly Ala Ile Ser Phe Phe Ile Phe Phe 
785                 790                 795                 800 


Phe Thr Leu Leu Val Leu Ala Arg Gln Asn Glu Tyr Tyr Cys Arg Leu 
                805                 810                 815     


Asp Phe Leu Trp Lys Lys Lys Leu Arg Gln Glu Arg Glu Glu Thr Glu 
            820                 825                 830         


Thr Met Glu Asn Leu Thr Arg Leu Leu Leu Glu Asn Val Leu Pro Ala 
        835                 840                 845             


His Val Ala Pro Gln Phe Ile Gly Gln Asn Arg Arg Asn Glu Asp Leu 
    850                 855                 860                 


Tyr His Gln Ser Tyr Glu Cys Val Cys Val Leu Phe Ala Ser Val Pro 
865                 870                 875                 880 


Asp Phe Lys Glu Phe Tyr Ser Glu Ser Asn Ile Asn His Glu Gly Leu 
                885                 890                 895     


Glu Cys Leu Arg Leu Leu Asn Glu Ile Ile Ala Asp Phe Asp Glu Leu 
            900                 905                 910         


Leu Ser Lys Pro Lys Phe Ser Gly Val Glu Lys Ile Lys Thr Ile Gly 
        915                 920                 925             


Ser Thr Tyr Met Ala Ala Thr Gly Leu Asn Ala Thr Ser Gly Gln Asp 
    930                 935                 940                 


Ala Gln Gln Asp Ala Glu Arg Ser Cys Ser His Leu Gly Thr Met Val 
945                 950                 955                 960 


Glu Phe Ala Val Ala Leu Gly Ser Lys Leu Asp Val Ile Asn Lys His 
                965                 970                 975     


Ser Phe Asn Asn Phe Arg Leu Arg Val Gly Leu Asn His Gly Pro Val 
            980                 985                 990         


Val Ala Gly Val Ile Gly Ala Gln  Lys Pro Gln Tyr Asp  Ile Trp Gly 
        995                 1000                 1005             


Asn Thr  Val Asn Val Ala Ser  Arg Met Glu Ser Thr  Gly Val Leu 
    1010                 1015                 1020             


Gly Lys  Ile Gln Val Thr Glu  Glu Thr Ala Trp Ala  Leu Gln Ser 
    1025                 1030                 1035             


Leu Gly  Tyr Thr Cys Tyr Ser  Arg Gly Val Ile Lys  Val Lys Gly 
    1040                 1045                 1050             


Lys Gly  Gln Leu Cys Thr Tyr  Phe Leu Asn Thr Asp  Leu Thr Arg 
    1055                 1060                 1065             


Thr Gly  Pro Pro Ser Ala Thr  Leu Gly 
    1070                 1075         


<210>  24
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asn Glu Pro Thr Glu Asn Arg Leu Gly Cys Ser Arg Thr Pro Glu 
1               5                   10                  15      


Pro Asp Ile Arg Leu Arg Lys Gly His Gln Leu Asp Gly Thr Arg Arg 
            20                  25                  30          


Gly Asp Asn Asp Ser His Gln Gly Asp Leu Glu Pro Ile Leu Glu Ala 
        35                  40                  45              


Ser Val Leu Ser Ser His His Lys Lys Ser Ser Glu Glu His Glu Tyr 
    50                  55                  60                  


Ser Asp Glu Ala Pro Gln Glu Asp Glu Gly Phe Met Gly Met Ser Pro 
65                  70                  75                  80  


Leu Leu Gln Ala His His Ala Met Glu Lys Met Glu Glu Phe Val Cys 
                85                  90                  95      


Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro His Asp Val Leu Pro 
            100                 105                 110         


Asp Trp Leu Lys Asp Asn Asp Phe Leu Leu His Gly His Arg Pro Pro 
        115                 120                 125             


Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile Phe Arg Ile His Thr 
    130                 135                 140                 


Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly Cys Val Phe Phe Leu 
145                 150                 155                 160 


Cys Leu Gly Ile Phe Tyr Met Phe Arg Pro Asn Ile Ser Phe Val Ala 
                165                 170                 175     


Pro Leu Gln Glu Lys Val Val Phe Gly Leu Phe Phe Leu Gly Ala Ile 
            180                 185                 190         


Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr Val Tyr Cys His Ser 
        195                 200                 205             


Glu Gly Val Ser Arg Leu Phe Ser Lys Leu Asp Tyr Ser Gly Ile Ala 
    210                 215                 220                 


Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu Tyr Tyr Ser Phe Tyr 
225                 230                 235                 240 


Cys Asn Pro Gln Pro Cys Phe Ile Tyr Leu Ile Val Ile Cys Val Leu 
                245                 250                 255     


Gly Ile Ala Ala Ile Ile Val Ser Gln Trp Asp Met Phe Ala Thr Pro 
            260                 265                 270         


Gln Tyr Arg Gly Val Arg Ala Gly Val Phe Leu Gly Leu Gly Leu Ser 
        275                 280                 285             


Gly Ile Ile Pro Thr Leu His Tyr Val Ile Ser Glu Gly Phe Leu Lys 
    290                 295                 300                 


Ala Ala Thr Ile Gly Gln Ile Gly Trp Leu Met Leu Met Ala Ser Leu 
305                 310                 315                 320 


Tyr Ile Thr Gly Ala Ala Leu Tyr Ala Ala Arg Ile Pro Glu Arg Phe 
                325                 330                 335     


Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser His Gln Leu Phe His 
            340                 345                 350         


Ile Phe Val Val Ala Gly Ala Phe Val His Phe His Gly Val Ser Asn 
        355                 360                 365             


Leu Gln Glu Phe Arg Phe Met Ile Gly Gly Gly Cys Ser Glu Glu Asp 
    370                 375                 380                 


Ala Leu 
385     


<210>  25
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Arg 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Thr Gln Gln Arg Asp Glu Val Trp 
            20                  25                  30          


Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  


Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  


Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      


Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         


Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 


Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 


Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     


Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         


Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             


Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 


Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 


His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     


Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         


Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             


Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 


Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 


Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     


Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         


Gly Tyr Ser Ser Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             


Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Thr 
    370                 375                 380                 


Glu Asp Phe Val Gly His Gln Gly Thr Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 


Ser Gln Gly Arg Asn Cys Ser Thr Asn Asp Ser Leu Leu 
                405                 410             


<210>  26
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210>  27
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 
        195                 200                 205             


Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
        435                 440                 445             


Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Asn Glu Asn Arg Glu Lys Val Asn Asp Gln 
            500                 505                 510         


Ala Lys Leu Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu 
        515                 520                 525             


Val Ala Gly Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala 
    530                 535                 540                 


Ser Lys His Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys 
545                 550                 555                 560 


Leu Glu Glu Asn Asn His Lys Thr Glu Ala 
                565                 570 


<210>  28
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
        115                 120                 125             


Lys Val Phe Ser Lys 
    130             


<210>  29
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 
        195                 200                 205             


Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
        435                 440                 445             


Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 
            500                 505                 510         


Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 
        515                 520                 525             


Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 
    530                 535                 540                 


Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His 
545                 550                 555                 560 


Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 
                565                 570                 575     


Asn Asn His Lys Thr Glu Ala 
            580             


<210>  30
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu 
1               5                   10                  15      


Lys Ile Gln Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser 
            20                  25                  30          


Val Ser Gly Lys Lys Phe Pro Val Phe Asn Pro Ala Thr Glu Glu Glu 
        35                  40                  45              


Leu Cys Gln Val Glu Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
    50                  55                  60                  


Lys Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met 
65                  70                  75                  80  


Asp Ala Ser Glu Arg Gly Arg Leu Leu Tyr Lys Leu Ala Asp Leu Ile 
                85                  90                  95      


Glu Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Gly Gly 
            100                 105                 110         


Lys Leu Tyr Ser Asn Ala Tyr Leu Asn Asp Leu Ala Gly Cys Ile Lys 
        115                 120                 125             


Thr Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr 
    130                 135                 140                 


Ile Pro Ile Asp Gly Asn Phe Phe Thr Tyr Thr Arg His Glu Pro Ile 
145                 150                 155                 160 


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Leu 
                165                 170                 175     


Ile Trp Lys Ile Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val 
            180                 185                 190         


Lys Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Val Ala Ser Leu 
        195                 200                 205             


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
    210                 215                 220                 


Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ser Ser His Met Asp Ile Asp 
225                 230                 235                 240 


Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu 
                245                 250                 255     


Ala Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         


Lys Ser Pro Cys Ile Val Leu Ala Asp Ala Asp Leu Asp Asn Ala Val 
        275                 280                 285             


Glu Phe Ala His His Gly Val Phe Tyr His Gln Gly Gln Cys Cys Ile 
    290                 295                 300                 


Ala Ala Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val 
305                 310                 315                 320 


Arg Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu 
                325                 330                 335     


Thr Pro Gly Val Thr Gln Gly Pro Gln Ile Asp Lys Glu Gln Tyr Asp 
            340                 345                 350         


Lys Ile Leu Asp Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu 
        355                 360                 365             


Glu Cys Gly Gly Gly Pro Trp Gly Asn Lys Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 


Thr Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu 
385                 390                 395                 400 


Ile Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Leu Asp Asp 
                405                 410                 415     


Val Ile Lys Arg Ala Asn Asn Thr Phe Tyr Gly Leu Ser Ala Gly Val 
            420                 425                 430         


Phe Thr Lys Asp Ile Asp Lys Ala Ile Thr Ile Ser Ser Ala Leu Gln 
        435                 440                 445             


Ala Gly Thr Val Trp Val Asn Cys Tyr Gly Val Val Ser Ala Gln Cys 
    450                 455                 460                 


Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu 
465                 470                 475                 480 


Tyr Gly Phe His Glu Tyr Thr Glu Val Lys Thr Val Thr Val Lys Ile 
                485                 490                 495     


Ser Gln Lys Asn Ser 
            500     


<210>  31
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ser Leu Arg Val His Thr Leu Pro Thr Leu Leu Gly Ala Val Val 
1               5                   10                  15      


Arg Pro Gly Cys Arg Glu Leu Leu Cys Leu Leu Met Ile Thr Val Thr 
            20                  25                  30          


Val Gly Pro Gly Ala Ser Gly Val Cys Pro Thr Ala Cys Ile Cys Ala 
        35                  40                  45              


Thr Asp Ile Val Ser Cys Thr Asn Lys Asn Leu Ser Lys Val Pro Gly 
    50                  55                  60                  


Asn Leu Phe Arg Leu Ile Lys Arg Leu Asp Leu Ser Tyr Asn Arg Ile 
65                  70                  75                  80  


Gly Leu Leu Asp Ser Glu Trp Ile Pro Val Ser Phe Ala Lys Leu Asn 
                85                  90                  95      


Thr Leu Ile Leu Arg His Asn Asn Ile Thr Ser Ile Ser Thr Gly Ser 
            100                 105                 110         


Phe Ser Thr Thr Pro Asn Leu Lys Cys Leu Asp Leu Ser Ser Asn Lys 
        115                 120                 125             


Leu Lys Thr Val Lys Asn Ala Val Phe Gln Glu Leu Lys Val Leu Glu 
    130                 135                 140                 


Val Leu Leu Leu Tyr Asn Asn His Ile Ser Tyr Leu Asp Pro Ser Ala 
145                 150                 155                 160 


Phe Gly Gly Leu Ser Gln Leu Gln Lys Leu Tyr Leu Ser Gly Asn Phe 
                165                 170                 175     


Leu Thr Gln Phe Pro Met Asp Leu Tyr Val Gly Arg Phe Lys Leu Ala 
            180                 185                 190         


Glu Leu Met Phe Leu Asp Val Ser Tyr Asn Arg Ile Pro Ser Met Pro 
        195                 200                 205             


Met His His Ile Asn Leu Val Pro Gly Lys Gln Leu Arg Gly Ile Tyr 
    210                 215                 220                 


Leu His Gly Asn Pro Phe Val Cys Asp Cys Ser Leu Tyr Ser Leu Leu 
225                 230                 235                 240 


Val Phe Trp Tyr Arg Arg His Phe Ser Ser Val Met Asp Phe Lys Asn 
                245                 250                 255     


Asp Tyr Thr Cys Arg Leu Trp Ser Asp Ser Arg His Ser Arg Gln Val 
            260                 265                 270         


Leu Leu Leu Gln Asp Ser Phe Met Asn Cys Ser Asp Ser Ile Ile Asn 
        275                 280                 285             


Gly Ser Phe Arg Ala Leu Gly Phe Ile His Glu Ala Gln Val Gly Glu 
    290                 295                 300                 


Arg Leu Met Val His Cys Asp Ser Lys Thr Gly Asn Ala Asn Thr Asp 
305                 310                 315                 320 


Phe Ile Trp Val Gly Pro Asp Asn Arg Leu Leu Glu Pro Asp Lys Glu 
                325                 330                 335     


Met Glu Asn Phe Tyr Val Phe His Asn Gly Ser Leu Val Ile Glu Ser 
            340                 345                 350         


Pro Arg Phe Glu Asp Ala Gly Val Tyr Ser Cys Ile Ala Met Asn Lys 
        355                 360                 365             


Gln Arg Leu Leu Asn Glu Thr Val Asp Val Thr Ile Asn Val Ser Asn 
    370                 375                 380                 


Phe Thr Val Ser Arg Ser His Ala His Glu Ala Phe Asn Thr Ala Phe 
385                 390                 395                 400 


Thr Thr Leu Ala Ala Cys Val Ala Ser Ile Val Leu Val Leu Leu Tyr 
                405                 410                 415     


Leu Tyr Leu Thr Pro Cys Pro Cys Lys Cys Lys Thr Lys Arg Gln Lys 
            420                 425                 430         


Asn Met Leu His Gln Ser Asn Ala His Ser Ser Ile Leu Ser Pro Gly 
        435                 440                 445             


Pro Ala Ser Asp Ala Ser Ala Asp Glu Arg Lys Ala Gly Ala Gly Lys 
    450                 455                 460                 


Arg Val Val Phe Leu Glu Pro Leu Lys Asp Thr Ala Ala Gly Gln Asn 
465                 470                 475                 480 


Gly Lys Val Arg Leu Phe Pro Ser Glu Ala Val Ile Ala Glu Gly Ile 
                485                 490                 495     


Leu Lys Ser Thr Arg Gly Lys Ser Asp Ser Asp Ser Val Asn Ser Val 
            500                 505                 510         


Phe Ser Asp Thr Pro Phe Val Ala Ser Thr 
        515                 520         


<210>  32
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Leu Arg Val His Thr Leu Pro Thr Leu Leu Gly Ala Val Val 
1               5                   10                  15      


Arg Pro Gly Cys Arg Glu Leu Leu Cys Leu Leu Met Ile Thr Val Thr 
            20                  25                  30          


Val Gly Pro Gly Ala Ser Gly Val Cys Pro Thr Ala Cys Ile Cys Ala 
        35                  40                  45              


Thr Asp Ile Val Ser Cys Thr Asn Lys Asn Leu Ser Lys Val Pro Gly 
    50                  55                  60                  


Asn Leu Phe Arg Leu Ile Lys Arg Leu Asp Leu Ser Tyr Asn Arg Ile 
65                  70                  75                  80  


Gly Leu Leu Asp Ser Glu Trp Ile Pro Val Ser Phe Ala Lys Leu Asn 
                85                  90                  95      


Thr Leu Ile Leu Arg His Asn Asn Ile Thr Ser Ile Ser Thr Gly Ser 
            100                 105                 110         


Phe Ser Thr Thr Pro Asn Leu Lys Cys Leu Asp Leu Ser Ser Asn Lys 
        115                 120                 125             


Leu Lys Thr Val Lys Asn Ala Val Phe Gln Glu Leu Lys Val Leu Glu 
    130                 135                 140                 


Val Leu Leu Leu Tyr Asn Asn His Ile Ser Tyr Leu Asp Pro Ser Ala 
145                 150                 155                 160 


Phe Gly Gly Leu Ser Gln Leu Gln Lys Leu Tyr Leu Ser Gly Asn Phe 
                165                 170                 175     


Leu Thr Gln Phe Pro Met Asp Leu Tyr Val Gly Arg Phe Lys Leu Ala 
            180                 185                 190         


Glu Leu Met Phe Leu Asp Val Ser Tyr Asn Arg Ile Pro Ser Met Pro 
        195                 200                 205             


Met His His Ile Asn Leu Val Pro Gly Lys Gln Leu Arg Gly Ile Tyr 
    210                 215                 220                 


Leu His Gly Asn Pro Phe Val Cys Asp Cys Ser Leu Tyr Ser Leu Leu 
225                 230                 235                 240 


Val Phe Trp Tyr Arg Arg His Phe Ser Ser Val Met Asp Phe Lys Asn 
                245                 250                 255     


Asp Tyr Thr Cys Arg Leu Trp Ser Asp Ser Arg His Ser Arg Gln Val 
            260                 265                 270         


Leu Leu Leu Gln Asp Ser Phe Met Asn Cys Ser Asp Ser Ile Ile Asn 
        275                 280                 285             


Gly Ser Phe Arg Ala Leu Gly Phe Ile His Glu Ala Gln Val Gly Glu 
    290                 295                 300                 


Arg Leu Met Val His Cys Asp Ser Lys Thr Gly Asn Ala Asn Thr Asp 
305                 310                 315                 320 


Phe Ile Trp Val Gly Pro Asp Asn Arg Leu Leu Glu Pro Asp Lys Glu 
                325                 330                 335     


Met Glu Asn Phe Tyr Val Phe His Asn Gly Ser Leu Val Ile Glu Ser 
            340                 345                 350         


Pro Arg Phe Glu Asp Ala Gly Val Tyr Ser Cys Ile Ala Met Asn Lys 
        355                 360                 365             


Gln Arg Leu Leu Asn Glu Thr Val Asp Val Thr Ile Asn Val Ser Asn 
    370                 375                 380                 


Phe Thr Val Ser Arg Ser His Ala His Glu Ala Phe Asn Thr Ala Phe 
385                 390                 395                 400 


Thr Thr Leu Ala Ala Cys Val Ala Ser Ile Val Leu Val Leu Leu Tyr 
                405                 410                 415     


Leu Tyr Leu Thr Pro Cys Pro Cys Lys Cys Lys Thr Lys Arg Gln Lys 
            420                 425                 430         


Asn Met Leu His Gln Ser Asn Ala His Ser Ser Ile Leu Ser Pro Gly 
        435                 440                 445             


Pro Ala Ser Asp Ala Ser Ala Asp Glu Arg Lys Ala Gly Ala Gly Lys 
    450                 455                 460                 


Arg Val Val Phe Leu Glu Pro Leu Lys Asp Thr Ala Ala Gly Gln Asn 
465                 470                 475                 480 


Gly Lys Val Arg Leu Phe Pro Ser Glu Ala Val Ile Ala Glu Gly Ile 
                485                 490                 495     


Leu Lys Ser Thr Arg Gly Lys Ser Asp Ser Asp Ser Val Asn Ser Val 
            500                 505                 510         


Phe Ser Asp Thr Pro Phe Val Ala Ser Thr 
        515                 520         


<210>  33
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Asp Arg Pro Thr Ala Arg Arg Trp Gly Lys Cys Gly Pro Leu 
1               5                   10                  15      


Cys Thr Arg Glu Asn Ile Met Val Ala Phe Lys Gly Val Trp Thr Gln 
            20                  25                  30          


Ala Phe Trp Lys Ala Val Thr Ala Glu Phe Leu Ala Met Leu Ile Phe 
        35                  40                  45              


Val Leu Leu Ser Leu Gly Ser Thr Ile Asn Trp Gly Gly Thr Glu Lys 
    50                  55                  60                  


Pro Leu Pro Val Asp Met Val Leu Ile Ser Leu Cys Phe Gly Leu Ser 
65                  70                  75                  80  


Ile Ala Thr Met Val Gln Cys Phe Gly His Ile Ser Gly Gly His Ile 
                85                  90                  95      


Asn Pro Ala Val Thr Val Ala Met Val Cys Thr Arg Lys Ile Ser Ile 
            100                 105                 110         


Ala Lys Ser Val Phe Tyr Ile Ala Ala Gln Cys Leu Gly Ala Ile Ile 
        115                 120                 125             


Gly Ala Gly Ile Leu Tyr Leu Val Thr Pro Pro Ser Val Val Gly Gly 
    130                 135                 140                 


Leu Gly Val Thr Met Val His Gly Asn Leu Thr Ala Gly His Gly Leu 
145                 150                 155                 160 


Leu Val Glu Leu Ile Ile Thr Phe Gln Leu Val Phe Thr Ile Phe Ala 
                165                 170                 175     


Ser Cys Asp Ser Lys Arg Thr Asp Val Thr Gly Ser Ile Ala Leu Ala 
            180                 185                 190         


Ile Gly Phe Ser Val Ala Ile Gly His Leu Phe Ala Ile Asn Tyr Thr 
        195                 200                 205             


Gly Ala Ser Met Asn Pro Ala Arg Ser Phe Gly Pro Ala Val Ile Met 
    210                 215                 220                 


Gly Asn Trp Glu Asn His Trp Ile Tyr Trp Val Gly Pro Ile Ile Gly 
225                 230                 235                 240 


Ala Val Leu Ala Gly Gly Leu Tyr Glu Tyr Val Phe Cys Pro Asp Val 
                245                 250                 255     


Glu Phe Lys Arg Arg Phe Lys Glu Ala Phe Ser Lys Ala Ala Gln Gln 
            260                 265                 270         


Thr Lys Gly Ser Tyr Met Glu Val Glu Asp Asn Arg Ser Gln Val Glu 
        275                 280                 285             


Thr Asp Asp Leu Ile Leu Lys Pro Gly Val Val His Val Ile Asp Val 
    290                 295                 300                 


Asp Arg Gly Glu Glu Lys Lys Gly Lys Asp Gln Ser Gly Glu Val Leu 
305                 310                 315                 320 


Ser Ser Val 
            


<210>  34
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Val Ala Phe Lys Gly Val Trp Thr Gln Ala Phe Trp Lys Ala Val 
1               5                   10                  15      


Thr Ala Glu Phe Leu Ala Met Leu Ile Phe Val Leu Leu Ser Leu Gly 
            20                  25                  30          


Ser Thr Ile Asn Trp Gly Gly Thr Glu Lys Pro Leu Pro Val Asp Met 
        35                  40                  45              


Val Leu Ile Ser Leu Cys Phe Gly Leu Ser Ile Ala Thr Met Val Gln 
    50                  55                  60                  


Cys Phe Gly His Ile Ser Gly Gly His Ile Asn Pro Ala Val Thr Val 
65                  70                  75                  80  


Ala Met Val Cys Thr Arg Lys Ile Ser Ile Ala Lys Ser Val Phe Tyr 
                85                  90                  95      


Ile Ala Ala Gln Cys Leu Gly Ala Ile Ile Gly Ala Gly Ile Leu Tyr 
            100                 105                 110         


Leu Val Thr Pro Pro Ser Val Val Gly Gly Leu Gly Val Thr Met Val 
        115                 120                 125             


His Gly Asn Leu Thr Ala Gly His Gly Leu Leu Val Glu Leu Ile Ile 
    130                 135                 140                 


Thr Phe Gln Leu Val Phe Thr Ile Phe Ala Ser Cys Asp Ser Lys Arg 
145                 150                 155                 160 


Thr Asp Val Thr Gly Ser Ile Ala Leu Ala Ile Gly Phe Ser Val Ala 
                165                 170                 175     


Ile Gly His Leu Phe Ala Ile Asn Tyr Thr Gly Ala Ser Met Asn Pro 
            180                 185                 190         


Ala Arg Ser Phe Gly Pro Ala Val Ile Met Gly Asn Trp Glu Asn His 
        195                 200                 205             


Trp Ile Tyr Trp Val Gly Pro Ile Ile Gly Ala Val Leu Ala Gly Gly 
    210                 215                 220                 


Leu Tyr Glu Tyr Val Phe Cys Pro Asp Val Glu Phe Lys Arg Arg Phe 
225                 230                 235                 240 


Lys Glu Ala Phe Ser Lys Ala Ala Gln Gln Thr Lys Gly Ser Tyr Met 
                245                 250                 255     


Glu Val Glu Asp Asn Arg Ser Gln Val Glu Thr Asp Asp Leu Ile Leu 
            260                 265                 270         


Lys Pro Gly Val Val His Val Ile Asp Val Asp Arg Gly Glu Glu Lys 
        275                 280                 285             


Lys Gly Lys Asp Gln Ser Gly Glu Val Leu Ser Ser Val 
    290                 295                 300     


<210>  35
<211>  1196
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gly His Phe Glu Lys Gly Gln His Ala Leu Leu Asn Glu Gly Glu 
1               5                   10                  15      


Glu Asn Glu Met Glu Ile Phe Gly Tyr Arg Thr Gln Gly Cys Arg Lys 
            20                  25                  30          


Ser Leu Cys Leu Ala Gly Ser Ile Phe Ser Phe Gly Ile Leu Pro Leu 
        35                  40                  45              


Val Phe Tyr Trp Arg Pro Ala Trp His Val Trp Ala His Cys Val Pro 
    50                  55                  60                  


Cys Ser Leu Gln Glu Ala Asp Thr Val Leu Leu Arg Thr Thr Asp Glu 
65                  70                  75                  80  


Phe Gln Ile Tyr Ser Trp Lys Lys Val Ile Trp Ile Tyr Leu Ser Ala 
                85                  90                  95      


Leu Asn Ser Ala Phe Gly Leu Thr Pro Asp His Pro Leu Met Thr Asp 
            100                 105                 110         


Glu Glu Tyr Ile Ile Asn Arg Ala Ile Arg Lys Pro Asp Leu Lys Val 
        115                 120                 125             


Arg Cys Ile Lys Val Gln Lys Ile Arg Tyr Val Trp Asn Tyr Leu Glu 
    130                 135                 140                 


Gly Gln Phe Gln Lys Ile Gly Ser Leu Glu Asp Trp Leu Ser Ser Ala 
145                 150                 155                 160 


Lys Ile His Gln Lys Phe Gly Ser Gly Leu Thr Arg Glu Glu Gln Glu 
                165                 170                 175     


Ile Arg Arg Leu Ile Cys Gly Pro Asn Thr Ile Asp Val Glu Val Thr 
            180                 185                 190         


Pro Ile Trp Lys Leu Leu Ile Lys Glu Val Leu Asn Pro Phe Tyr Ile 
        195                 200                 205             


Phe Gln Leu Phe Ser Val Cys Leu Trp Phe Ser Glu Asp Tyr Lys Glu 
    210                 215                 220                 


Tyr Ala Phe Ala Ile Ile Ile Met Ser Ile Ile Ser Ile Ser Leu Thr 
225                 230                 235                 240 


Val Tyr Asp Leu Arg Glu Gln Ser Val Lys Leu His His Leu Val Glu 
                245                 250                 255     


Ser His Asn Ser Ile Thr Val Ser Val Cys Gly Arg Lys Ala Gly Val 
            260                 265                 270         


Gln Glu Leu Glu Ser Arg Val Leu Val Pro Gly Asp Leu Leu Ile Leu 
        275                 280                 285             


Thr Gly Asn Lys Val Leu Met Pro Cys Asp Ala Val Leu Ile Glu Gly 
    290                 295                 300                 


Ser Cys Val Val Asp Glu Gly Met Leu Thr Gly Glu Ser Ile Pro Val 
305                 310                 315                 320 


Thr Lys Thr Pro Leu Pro Lys Met Asp Ser Ser Val Pro Trp Lys Thr 
                325                 330                 335     


Gln Ser Glu Ala Asp Tyr Lys Arg His Val Leu Phe Cys Gly Thr Glu 
            340                 345                 350         


Val Ile Gln Ala Lys Ala Ala Cys Ser Gly Thr Val Arg Ala Val Val 
        355                 360                 365             


Leu Gln Thr Gly Phe Asn Thr Ala Lys Gly Asp Leu Val Arg Ser Ile 
    370                 375                 380                 


Leu Tyr Pro Lys Pro Val Asn Phe Gln Leu Tyr Arg Asp Ala Ile Arg 
385                 390                 395                 400 


Phe Leu Leu Cys Leu Val Gly Thr Ala Thr Ile Gly Met Ile Tyr Thr 
                405                 410                 415     


Leu Cys Val Tyr Val Leu Ser Gly Glu Pro Pro Glu Glu Val Val Arg 
            420                 425                 430         


Lys Ala Leu Asp Val Ile Thr Ile Ala Val Pro Pro Ala Leu Pro Ala 
        435                 440                 445             


Ala Leu Thr Thr Gly Ile Ile Tyr Ala Gln Arg Arg Leu Lys Lys Arg 
    450                 455                 460                 


Gly Ile Phe Cys Ile Ser Pro Gln Arg Ile Asn Val Cys Gly Gln Leu 
465                 470                 475                 480 


Asn Leu Val Cys Phe Asp Lys Thr Gly Thr Leu Thr Arg Asp Gly Leu 
                485                 490                 495     


Asp Leu Trp Gly Val Val Ser Cys Asp Arg Asn Gly Phe Gln Glu Val 
            500                 505                 510         


His Ser Phe Ala Ser Gly Gln Ala Leu Pro Trp Gly Pro Leu Cys Ala 
        515                 520                 525             


Ala Met Ala Ser Cys His Ser Leu Ile Leu Leu Asp Gly Thr Ile Gln 
    530                 535                 540                 


Gly Asp Pro Leu Asp Leu Lys Met Phe Glu Ala Thr Thr Trp Glu Met 
545                 550                 555                 560 


Ala Phe Ser Gly Asp Asp Phe His Ile Lys Gly Val Pro Ala His Ala 
                565                 570                 575     


Met Val Val Lys Pro Cys Arg Thr Ala Ser Gln Val Pro Val Glu Gly 
            580                 585                 590         


Ile Ala Ile Leu His Gln Phe Pro Phe Ser Ser Ala Leu Gln Arg Met 
        595                 600                 605             


Thr Val Ile Val Gln Glu Met Gly Gly Asp Arg Leu Ala Phe Met Lys 
    610                 615                 620                 


Gly Ala Pro Glu Arg Val Ala Ser Phe Cys Gln Pro Glu Thr Val Pro 
625                 630                 635                 640 


Thr Ser Phe Val Ser Glu Leu Gln Ile Tyr Thr Thr Gln Gly Phe Arg 
                645                 650                 655     


Val Ile Ala Leu Ala Tyr Lys Lys Leu Glu Asn Asp His His Ala Thr 
            660                 665                 670         


Thr Leu Thr Arg Glu Thr Val Glu Ser Asp Leu Ile Phe Leu Gly Leu 
        675                 680                 685             


Leu Ile Leu Glu Asn Arg Leu Lys Glu Glu Thr Lys Pro Val Leu Glu 
    690                 695                 700                 


Glu Leu Ile Ser Ala Arg Ile Arg Thr Val Met Ile Thr Gly Asp Asn 
705                 710                 715                 720 


Leu Gln Thr Ala Ile Thr Val Ala Arg Lys Ser Gly Met Val Ser Glu 
                725                 730                 735     


Ser Gln Lys Val Ile Leu Ile Glu Ala Asn Glu Thr Thr Gly Ser Ser 
            740                 745                 750         


Ser Ala Ser Ile Ser Trp Thr Leu Val Glu Glu Lys Lys His Ile Met 
        755                 760                 765             


Tyr Gly Asn Gln Asp Asn Tyr Ile Asn Ile Arg Asp Glu Val Ser Asp 
    770                 775                 780                 


Lys Gly Arg Glu Gly Ser Tyr His Phe Ala Leu Thr Gly Lys Ser Phe 
785                 790                 795                 800 


His Val Ile Ser Gln His Phe Ser Ser Leu Leu Pro Lys Ile Leu Ile 
                805                 810                 815     


Asn Gly Thr Ile Phe Ala Arg Met Ser Pro Gly Gln Lys Ser Ser Leu 
            820                 825                 830         


Val Glu Glu Phe Gln Lys Leu Asp Tyr Phe Val Gly Met Cys Gly Asp 
        835                 840                 845             


Gly Ala Asn Asp Cys Gly Ala Leu Lys Met Ala His Val Gly Ile Ser 
    850                 855                 860                 


Leu Ser Glu Gln Glu Ala Ser Val Ala Ser Pro Phe Thr Ser Lys Thr 
865                 870                 875                 880 


Pro Asn Ile Glu Cys Val Pro His Leu Ile Lys Glu Gly Arg Ala Ala 
                885                 890                 895     


Leu Val Thr Ser Phe Cys Met Phe Lys Tyr Met Ala Leu Tyr Ser Met 
            900                 905                 910         


Ile Gln Tyr Val Gly Val Leu Leu Leu Tyr Trp Glu Thr Asn Ser Leu 
        915                 920                 925             


Ser Asn Tyr Gln Phe Leu Phe Gln Asp Leu Ala Ile Thr Thr Leu Ile 
    930                 935                 940                 


Gly Val Thr Met Asn Leu Asn Gly Ala Tyr Pro Lys Leu Val Pro Phe 
945                 950                 955                 960 


Arg Pro Ala Gly Arg Leu Ile Ser Pro Pro Leu Leu Leu Ser Val Ile 
                965                 970                 975     


Phe Asn Ile Leu Leu Ser Leu Ala Met His Ile Ala Gly Phe Ile Leu 
            980                 985                 990         


Val Gln Arg Gln Pro Trp Tyr Ser  Val Glu Ile His Ser  Ala Cys Thr 
        995                 1000                 1005             


Val Gln  Asn Glu Ser Ile Ser  Glu Leu Thr Met Ser  Pro Thr Ala 
    1010                 1015                 1020             


Pro Glu  Lys Met Glu Ser Asn  Ser Thr Phe Thr Ser  Phe Glu Asn 
    1025                 1030                 1035             


Thr Thr  Val Trp Phe Leu Gly  Thr Ile Asn Cys Ile  Thr Val Ala 
    1040                 1045                 1050             


Leu Val  Phe Ser Lys Gly Lys  Pro Phe Arg Gln Pro  Thr Tyr Thr 
    1055                 1060                 1065             


Asn Tyr  Ile Phe Val Leu Val  Leu Ile Ile Gln Leu  Gly Val Cys 
    1070                 1075                 1080             


Leu Phe  Ile Leu Phe Ala Asp  Ile Pro Glu Leu Tyr  Arg Arg Leu 
    1085                 1090                 1095             


Asp Leu  Leu Cys Thr Pro Val  Leu Trp Arg Ala Ser  Ile Val Ile 
    1100                 1105                 1110             


Met Leu  Ser Leu Asn Phe Ile  Val Ser Leu Val Ala  Glu Glu Ala 
    1115                 1120                 1125             


Val Ile  Glu Asn Arg Ala Leu  Trp Met Met Ile Lys  Arg Cys Phe 
    1130                 1135                 1140             


Gly Tyr  Gln Ser Lys Ser Gln  Tyr Arg Ile Trp Gln  Arg Asp Leu 
    1145                 1150                 1155             


Ala Asn  Asp Pro Ser Trp Pro  Pro Leu Asn Gln Thr  Ser His Ser 
    1160                 1165                 1170             


Asp Met  Pro Glu Cys Gly Arg  Gly Val Ser Tyr Ser  Asn Pro Val 
    1175                 1180                 1185             


Phe Glu  Ser Asn Glu Glu Gln  Leu 
    1190                 1195     


<210>  36
<211>  1020
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Arg Gly Ala Gly Arg Glu Tyr Ser Pro Ala Ala Thr Thr Ala 
1               5                   10                  15      


Glu Asn Gly Gly Gly Lys Lys Lys Gln Lys Glu Lys Glu Leu Asp Glu 
            20                  25                  30          


Leu Lys Lys Glu Val Ala Met Asp Asp His Lys Leu Ser Leu Asp Glu 
        35                  40                  45              


Leu Gly Arg Lys Tyr Gln Val Asp Leu Ser Lys Gly Leu Thr Asn Gln 
    50                  55                  60                  


Arg Ala Gln Asp Val Leu Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro 
65                  70                  75                  80  


Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln Leu Phe Gly 
                85                  90                  95      


Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala 
            100                 105                 110         


Tyr Gly Ile Gln Ala Ala Met Glu Asp Glu Pro Ser Asn Asp Asn Leu 
        115                 120                 125             


Tyr Leu Gly Val Val Leu Ala Ala Val Val Ile Val Thr Gly Cys Phe 
    130                 135                 140                 


Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Asp Ser Phe Lys 
145                 150                 155                 160 


Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Glu Gly Glu Lys Met 
                165                 170                 175     


Gln Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys 
            180                 185                 190         


Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile Ile Ser Ser His Gly 
        195                 200                 205             


Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr 
    210                 215                 220                 


Arg Ser Pro Glu Phe Thr His Glu Asn Pro Leu Glu Thr Arg Asn Ile 
225                 230                 235                 240 


Cys Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val 
                245                 250                 255     


Ile Ala Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala 
            260                 265                 270         


Ser Gly Leu Glu Val Gly Arg Thr Pro Ile Ala Met Glu Ile Glu His 
        275                 280                 285             


Phe Ile Gln Leu Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe 
    290                 295                 300                 


Phe Val Leu Ser Leu Ile Leu Gly Tyr Ser Trp Leu Glu Ala Val Ile 
305                 310                 315                 320 


Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala 
                325                 330                 335     


Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys 
            340                 345                 350         


Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr 
        355                 360                 365             


Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met 
    370                 375                 380                 


Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr 
385                 390                 395                 400 


Thr Glu Asp Gln Ser Gly Ala Thr Phe Asp Lys Arg Ser Pro Thr Trp 
                405                 410                 415     


Thr Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Lys 
            420                 425                 430         


Ala Gly Gln Glu Asn Ile Ser Val Ser Lys Arg Asp Thr Ala Gly Asp 
        435                 440                 445             


Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Ser Cys Gly Ser 
    450                 455                 460                 


Val Arg Lys Met Arg Asp Arg Asn Pro Lys Val Ala Glu Ile Pro Phe 
465                 470                 475                 480 


Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Glu Arg Glu Asp Ser 
                485                 490                 495     


Pro Gln Ser His Val Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu 
            500                 505                 510         


Asp Arg Cys Ser Thr Ile Leu Val Gln Gly Lys Glu Ile Pro Leu Asp 
        515                 520                 525             


Lys Glu Met Gln Asp Ala Phe Gln Asn Ala Tyr Met Glu Leu Gly Gly 
    530                 535                 540                 


Leu Gly Glu Arg Val Leu Gly Phe Cys Gln Leu Asn Leu Pro Ser Gly 
545                 550                 555                 560 


Lys Phe Pro Arg Gly Phe Lys Phe Asp Thr Asp Glu Leu Asn Phe Pro 
                565                 570                 575     


Thr Glu Lys Leu Cys Phe Val Gly Leu Met Ser Met Ile Asp Pro Pro 
            580                 585                 590         


Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile 
        595                 600                 605             


Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile 
    610                 615                 620                 


Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp 
625                 630                 635                 640 


Ile Ala Ala Arg Leu Asn Ile Pro Met Ser Gln Val Asn Pro Arg Glu 
                645                 650                 655     


Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser 
            660                 665                 670         


Glu Gln Leu Asp Glu Ile Leu Lys Asn His Thr Glu Ile Val Phe Ala 
        675                 680                 685             


Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg 
    690                 695                 700                 


Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro 
705                 710                 715                 720 


Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Met Gly Ile Ser Gly Ser 
                725                 730                 735     


Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe 
            740                 745                 750         


Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn 
        755                 760                 765             


Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile 
    770                 775                 780                 


Thr Pro Phe Leu Leu Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly 
785                 790                 795                 800 


Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala 
                805                 810                 815     


Ile Ser Leu Ala Tyr Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln 
            820                 825                 830         


Pro Arg Asn Ser Gln Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser 
        835                 840                 845             


Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe 
    850                 855                 860                 


Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ser Arg Leu 
865                 870                 875                 880 


Leu Gly Ile Arg Leu Asp Trp Asp Asp Arg Thr Met Asn Asp Leu Glu 
                885                 890                 895     


Asp Ser Tyr Gly Gln Glu Trp Thr Tyr Glu Gln Arg Lys Val Val Glu 
            900                 905                 910         


Phe Thr Cys His Thr Ala Phe Phe Ala Ser Ile Val Val Val Gln Trp 
        915                 920                 925             


Ala Asp Leu Ile Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln 
    930                 935                 940                 


Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Leu Glu Glu Thr Ala 
945                 950                 955                 960 


Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg 
                965                 970                 975     


Met Tyr Pro Leu Lys Val Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser 
            980                 985                 990         


Leu Leu Ile Phe Ile Tyr Asp Glu  Val Arg Lys Leu Ile  Leu Arg Arg 
        995                 1000                 1005             


Tyr Pro  Gly Gly Trp Val Glu  Lys Glu Thr Tyr Tyr  
    1010                 1015                 1020 


<210>  37
<211>  1047
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Thr Asp Asn Ile Pro Leu Gln Pro Val Arg Gln Lys Lys Arg Met 
1               5                   10                  15      


Asp Ser Arg Pro Arg Ala Gly Cys Cys Glu Trp Leu Arg Cys Cys Gly 
            20                  25                  30          


Gly Gly Glu Ala Arg Pro Arg Thr Val Trp Leu Gly His Pro Glu Lys 
        35                  40                  45              


Arg Asp Gln Arg Tyr Pro Arg Asn Val Ile Asn Asn Gln Lys Tyr Asn 
    50                  55                  60                  


Phe Phe Thr Phe Leu Pro Gly Val Leu Phe Asn Gln Phe Lys Tyr Phe 
65                  70                  75                  80  


Phe Asn Leu Tyr Phe Leu Leu Leu Ala Cys Ser Gln Phe Val Pro Glu 
                85                  90                  95      


Met Arg Leu Gly Ala Leu Tyr Thr Tyr Trp Val Pro Leu Gly Phe Val 
            100                 105                 110         


Leu Ala Val Thr Val Ile Arg Glu Ala Val Glu Glu Ile Arg Cys Tyr 
        115                 120                 125             


Val Arg Asp Lys Glu Val Asn Ser Gln Val Tyr Ser Arg Leu Thr Ala 
    130                 135                 140                 


Arg Gly Thr Val Lys Val Lys Ser Ser Asn Ile Gln Val Gly Asp Leu 
145                 150                 155                 160 


Ile Ile Val Glu Lys Asn Gln Arg Val Pro Ala Asp Met Ile Phe Leu 
                165                 170                 175     


Arg Thr Ser Glu Lys Asn Gly Ser Cys Phe Leu Arg Thr Asp Gln Leu 
            180                 185                 190         


Asp Gly Glu Thr Asp Trp Lys Leu Arg Leu Pro Val Ala Cys Thr Gln 
        195                 200                 205             


Arg Leu Pro Thr Ala Ala Asp Leu Leu Gln Ile Arg Ser Tyr Val Tyr 
    210                 215                 220                 


Ala Glu Glu Pro Asn Ile Asp Ile His Asn Phe Val Gly Thr Phe Thr 
225                 230                 235                 240 


Arg Glu Asp Ser Asp Pro Pro Ile Ser Glu Ser Leu Ser Ile Glu Asn 
                245                 250                 255     


Thr Leu Trp Ala Gly Thr Val Val Ala Ser Gly Thr Val Val Gly Val 
            260                 265                 270         


Val Leu Tyr Thr Gly Arg Glu Leu Arg Ser Val Met Asn Thr Ser Asn 
        275                 280                 285             


Pro Arg Ser Lys Ile Gly Leu Phe Asp Leu Glu Val Asn Cys Leu Thr 
    290                 295                 300                 


Lys Ile Leu Phe Gly Ala Leu Val Val Val Ser Leu Val Met Val Ala 
305                 310                 315                 320 


Leu Gln His Phe Ala Gly Arg Trp Tyr Leu Gln Ile Ile Arg Phe Leu 
                325                 330                 335     


Leu Leu Phe Ser Asn Ile Ile Pro Ile Ser Leu Arg Val Asn Leu Asp 
            340                 345                 350         


Met Gly Lys Ile Val Tyr Ser Trp Val Ile Arg Arg Asp Ser Lys Ile 
        355                 360                 365             


Pro Gly Thr Val Val Arg Ser Ser Thr Ile Pro Glu Gln Leu Gly Arg 
    370                 375                 380                 


Ile Ser Tyr Leu Leu Thr Asp Lys Thr Gly Thr Leu Thr Gln Asn Glu 
385                 390                 395                 400 


Met Ile Phe Lys Arg Leu His Leu Gly Thr Val Ala Tyr Gly Leu Asp 
                405                 410                 415     


Ser Met Asp Glu Val Gln Ser His Ile Phe Ser Ile Tyr Thr Gln Gln 
            420                 425                 430         


Ser Gln Asp Pro Pro Ala Gln Lys Gly Pro Thr Leu Thr Thr Lys Val 
        435                 440                 445             


Arg Arg Thr Met Ser Ser Arg Val His Glu Ala Val Lys Ala Ile Ala 
    450                 455                 460                 


Leu Cys His Asn Val Thr Pro Val Tyr Glu Ser Asn Gly Val Thr Asp 
465                 470                 475                 480 


Gln Ala Glu Ala Glu Lys Gln Tyr Glu Asp Ser Cys Arg Val Tyr Gln 
                485                 490                 495     


Ala Ser Ser Pro Asp Glu Val Ala Leu Val Gln Trp Thr Glu Ser Val 
            500                 505                 510         


Gly Leu Thr Leu Val Gly Arg Asp Gln Ser Ser Met Gln Leu Arg Thr 
        515                 520                 525             


Pro Gly Asp Gln Ile Leu Asn Phe Thr Ile Leu Gln Ile Phe Pro Phe 
    530                 535                 540                 


Thr Tyr Glu Ser Lys Arg Met Gly Ile Ile Val Arg Asp Glu Ser Thr 
545                 550                 555                 560 


Gly Glu Ile Thr Phe Tyr Met Lys Gly Ala Asp Val Val Met Ala Gly 
                565                 570                 575     


Ile Val Gln Tyr Asn Asp Trp Leu Glu Glu Glu Cys Gly Asn Met Ala 
            580                 585                 590         


Arg Glu Gly Leu Arg Val Leu Val Val Ala Lys Lys Ser Leu Ala Glu 
        595                 600                 605             


Glu Gln Tyr Gln Asp Phe Glu Ala Arg Tyr Val Gln Ala Lys Leu Ser 
    610                 615                 620                 


Val His Asp Arg Ser Leu Lys Val Ala Thr Val Ile Glu Ser Leu Glu 
625                 630                 635                 640 


Met Glu Met Glu Leu Leu Cys Leu Thr Gly Val Glu Asp Gln Leu Gln 
                645                 650                 655     


Ala Asp Val Arg Pro Thr Leu Glu Thr Leu Arg Asn Ala Gly Ile Lys 
            660                 665                 670         


Val Trp Met Leu Thr Gly Asp Lys Leu Glu Thr Ala Thr Cys Thr Ala 
        675                 680                 685             


Lys Asn Ala His Leu Val Thr Arg Asn Gln Asp Ile His Val Phe Arg 
    690                 695                 700                 


Leu Val Thr Asn Arg Gly Glu Ala His Leu Glu Leu Asn Ala Phe Arg 
705                 710                 715                 720 


Arg Lys His Asp Cys Ala Leu Val Ile Ser Gly Asp Ser Leu Glu Val 
                725                 730                 735     


Cys Leu Lys Tyr Tyr Glu Tyr Glu Phe Met Glu Leu Ala Cys Gln Cys 
            740                 745                 750         


Pro Ala Val Val Cys Cys Arg Cys Ala Pro Thr Gln Lys Ala Gln Ile 
        755                 760                 765             


Val Arg Leu Leu Gln Glu Arg Thr Gly Lys Leu Thr Cys Ala Val Gly 
    770                 775                 780                 


Asp Gly Gly Asn Asp Val Ser Met Ile Gln Glu Ser Asp Cys Gly Val 
785                 790                 795                 800 


Gly Val Glu Gly Lys Glu Gly Lys Gln Ala Ser Leu Ala Ala Asp Phe 
                805                 810                 815     


Ser Ile Thr Gln Phe Lys His Leu Gly Arg Leu Leu Met Val His Gly 
            820                 825                 830         


Arg Asn Ser Tyr Lys Arg Ser Ala Ala Leu Ser Gln Phe Val Ile His 
        835                 840                 845             


Arg Ser Leu Cys Ile Ser Thr Met Gln Ala Val Phe Ser Ser Val Phe 
    850                 855                 860                 


Tyr Phe Ala Ser Val Pro Leu Tyr Gln Gly Phe Leu Ile Ile Gly Tyr 
865                 870                 875                 880 


Ser Thr Ile Tyr Thr Met Phe Pro Val Phe Ser Leu Val Leu Asp Lys 
                885                 890                 895     


Asp Val Lys Ser Glu Val Ala Met Leu Tyr Pro Glu Leu Tyr Lys Asp 
            900                 905                 910         


Leu Leu Lys Gly Arg Pro Leu Ser Tyr Lys Thr Phe Leu Ile Trp Val 
        915                 920                 925             


Leu Ile Ser Ile Tyr Gln Gly Ser Thr Ile Met Tyr Gly Ala Leu Leu 
    930                 935                 940                 


Leu Phe Glu Ser Glu Phe Val His Ile Val Ala Ile Ser Phe Thr Ser 
945                 950                 955                 960 


Leu Ile Leu Thr Glu Leu Leu Met Val Ala Leu Thr Ile Gln Thr Trp 
                965                 970                 975     


His Trp Leu Met Thr Val Ala Glu Leu Leu Ser Leu Ala Cys Tyr Ile 
            980                 985                 990         


Ala Ser Leu Val Phe Leu His Glu  Phe Ile Asp Val Tyr  Phe Ile Ala 
        995                 1000                 1005             


Thr Leu  Ser Phe Leu Trp Lys  Val Ser Val Ile Thr  Leu Val Ser 
    1010                 1015                 1020             


Cys Leu  Pro Leu Tyr Val Leu  Lys Tyr Leu Arg Arg  Arg Phe Ser 
    1025                 1030                 1035             


Pro Pro  Ser Tyr Ser Lys Leu  Thr Ser 
    1040                 1045         


<210>  38
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
            420                 425                 430         


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
        435                 440                 445             


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
    450                 455                 460                 


Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val 
465                 470                 475                 480 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
                485                 490                 495     


Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu 
            500                 505                 510         


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
        515                 520                 525             


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
    530                 535                 540                 


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met 
545                 550                 555                 560 


Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
                565                 570                 575     


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
            580                 585                 590         


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
        595                 600                 605             


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
    610                 615                 620                 


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu 
625                 630                 635                 640 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr 
                645                 650                 655     


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
            660                 665                 670         


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
        675                 680                 685             


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
    690                 695                 700                 


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg 
                725                 730                 735     


Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
            740                 745                 750         


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
        755                 760                 765             


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
    770                 775                 780                 


Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala 
785                 790                 795                 800 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
                805                 810                 815     


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
            820                 825                 830         


Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala 
        835                 840                 845             


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr 
    850                 855                 860                 


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
865                 870                 875                 880 


Gln Glu Asp Gly Ala 
                885 


<210>  39
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  40
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Ser Gln Ser Pro Ala Asp Gln 
65                  70                  75                  80  


Leu Leu Ile Ala Pro Ala Asn Ser Pro Leu Gln Tyr Pro Leu Gln Gly 
                85                  90                  95      


Val Glu Val Gln Pro Leu Arg Ser Ile Leu Val Pro Gly Leu Ser Leu 
            100                 105                 110         


Gln Ala Ala Ser Gly Gln Glu Val Tyr Gln Val Asn Leu Thr Ala Ser 
        115                 120                 125             


Leu Gly Thr Trp Asp Val Ala Gly Glu Val Thr Gly Val Thr Leu Thr 
    130                 135                 140                 


Gly Glu Gly Gln Ala Asp Leu Thr Leu Val Ser Pro Gly Leu Asp Gln 
145                 150                 155                 160 


Leu Asn Arg Gln Leu Gln Leu Val Thr Tyr Ser Ser Arg Ser Tyr Gln 
                165                 170                 175     


Thr Asn Thr Ala Asp Thr Val Arg Phe Ser Thr Glu Gly His Glu Ala 
            180                 185                 190         


Ala Phe Thr Ile Arg Ile Arg His Pro Pro Asn Pro Arg Leu Tyr Pro 
        195                 200                 205             


Pro Gly Ser Leu Pro Gln Gly Ala Gln Tyr Asn Ile Ser Ala Leu Val 
    210                 215                 220                 


Thr Ile Ala Thr Lys Thr Phe Leu Arg Tyr Asp Arg Leu Arg Ala Leu 
225                 230                 235                 240 


Ile Thr Ser Ile Arg Arg Phe Tyr Pro Thr Val Thr Val Val Ile Ala 
                245                 250                 255     


Asp Asp Ser Asp Lys Pro Glu Arg Val Ser Gly Pro Tyr Val Glu His 
            260                 265                 270         


Tyr Leu Met Pro Phe Gly Lys Gly Trp Phe Ala Gly Arg Asn Leu Ala 
        275                 280                 285             


Val Ser Gln Val Thr Thr Lys Tyr Val Leu Trp Val Asp Asp Asp Phe 
    290                 295                 300                 


Val Phe Thr Ala Arg Thr Arg Leu Glu Arg Leu Val Asp Val Leu Glu 
305                 310                 315                 320 


Arg Thr Pro Leu Asp Leu Val Gly Gly Ala Val Arg Glu Ile Ser Gly 
                325                 330                 335     


Phe Ala Thr Thr Tyr Arg Gln Leu Leu Ser Val Glu Pro Gly Ala Pro 
            340                 345                 350         


Gly Leu Gly Asn Cys Leu Arg Gln Arg Arg Gly Phe His His Glu Leu 
        355                 360                 365             


Val Gly Phe Pro Gly Cys Val Val Thr Asp Gly Val Val Asn Phe Phe 
    370                 375                 380                 


Leu Ala Arg Thr Asp Lys Val Arg Glu Val Gly Phe Asp Pro Arg Leu 
385                 390                 395                 400 


Ser Arg Val Ala His Leu Glu Phe Phe Leu Asp Gly Leu Gly Ser Leu 
                405                 410                 415     


Arg Val Gly Ser Cys Ser Asp Val Val Val Asp His Ala Ser Lys Leu 
            420                 425                 430         


Lys Leu Pro Trp Thr Ser Arg Asp Ala Gly Ala Glu Thr Tyr Ala Arg 
        435                 440                 445             


Tyr Arg Tyr Pro Gly Ser Leu Asp Glu Ser Gln Met Ala Lys His Arg 
    450                 455                 460                 


Leu Leu Phe Phe Lys His Arg Leu Gln Cys Met Thr Ser Gln 
465                 470                 475             


<210>  41
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             


Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 


Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 


Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                165                 170                 175     


Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
            180                 185                 190         


Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
        195                 200                 205             


Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
    210                 215                 220                 


Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Gly Ala Arg 
225                 230                 235                 240 


Pro Gly Trp Arg Asp Gly Gln Ala Gly Gln Thr Glu Lys Asn Gln Lys 
                245                 250                 255     


Gly Trp Ser Gly Gln Met Ala Glu Gly Met Gly Gly Ile Trp Ala Met 
            260                 265                 270         


Ala Arg Ala Val Gln Pro His Asn Gly Cys Phe Asn Trp Thr Ser Arg 
        275                 280                 285             


Ala Arg Gly Arg Lys Gly Ala Phe Val His Leu Gly Leu Glu Gln Ala 
    290                 295                 300                 


Arg Gly Lys Pro Glu Pro Trp Val Cys Leu Pro Phe Arg Pro Thr Val 
305                 310                 315                 320 


Gly Gly Pro Arg Lys Arg Leu Val 
                325             


<210>  42
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             


Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 


Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 


Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                165                 170                 175     


Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
            180                 185                 190         


Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
        195                 200                 205             


Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
    210                 215                 220                 


Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Val Arg Phe 
225                 230                 235                 240 


Ser Thr Glu Gly His Glu Ala Ala Phe Thr Ile Arg Ile Arg His Pro 
                245                 250                 255     


Pro Asn Pro Arg Leu Tyr Pro Pro Gly Ser Leu Pro Gln Gly Ala Gln 
            260                 265                 270         


Tyr Asn Ile Ser Ala Leu Val Thr Ile Ala Thr Lys Thr Phe Leu Arg 
        275                 280                 285             


Tyr Asp Arg Leu Arg Ala Leu Ile Thr Ser Ile Arg Arg Phe Tyr Pro 
    290                 295                 300                 


Thr Val Thr Val Val Ile Ala Asp Asp Ser Asp Lys Pro Glu Arg Val 
305                 310                 315                 320 


Ser Gly Pro Tyr Val Glu His Tyr Leu Met Pro Phe Gly Lys Gly Trp 
                325                 330                 335     


Phe Ala Gly Arg Asn Leu Ala Val Ser Gln Val Thr Thr Lys Tyr Val 
            340                 345                 350         


Leu Trp Val Asp Asp Asp Phe Val Phe Thr Ala Arg Thr Arg Leu Glu 
        355                 360                 365             


Arg Leu Val Asp Val Leu Glu Arg Thr Pro Leu Asp Leu Val Gly Gly 
    370                 375                 380                 


Ala Val Arg Glu Ile Ser Gly Phe Ala Thr Thr Tyr Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Val Glu Pro Gly Ala Pro Gly Leu Gly Asn Cys Leu Arg Gln Arg 
                405                 410                 415     


Arg Gly Phe His His Glu Leu Val Gly Phe Pro Gly Cys Val Val Thr 
            420                 425                 430         


Asp Gly Val Val Asn Phe Phe Leu Ala Arg Thr Asp Lys Val Arg Glu 
        435                 440                 445             


Val Gly Phe Asp Pro Arg Leu Ser Arg Val Ala His Leu Glu Phe Phe 
    450                 455                 460                 


Leu Asp Gly Leu Gly Ser Leu Arg Val Gly Ser Cys Ser Asp Val Val 
465                 470                 475                 480 


Val Asp His Ala Ser Lys Leu Lys Leu Pro Trp Thr Ser Arg Asp Ala 
                485                 490                 495     


Gly Ala Glu Thr Tyr Ala Arg Tyr Arg Tyr Pro Gly Ser Leu Asp Glu 
            500                 505                 510         


Ser Gln Met Ala Lys His Arg Leu Leu Phe Phe Lys His Arg Leu Gln 
        515                 520                 525             


Cys Met Thr Ser Gln 
    530             


<210>  43
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Asp Arg His Ser Ser Tyr Ile Phe Ile Trp Leu Gln Leu Glu Leu 
1               5                   10                  15      


Cys Ala Met Ala Val Leu Leu Thr Lys Gly Glu Ile Arg Cys Tyr Cys 
            20                  25                  30          


Asp Ala Ala His Cys Val Ala Thr Gly Tyr Met Cys Lys Ser Glu Leu 
        35                  40                  45              


Ser Ala Cys Phe Ser Arg Leu Leu Asp Pro Gln Asn Ser Asn Ser Pro 
    50                  55                  60                  


Leu Thr His Gly Cys Leu Asp Ser Leu Ala Ser Thr Thr Asp Ile Cys 
65                  70                  75                  80  


Gln Ala Lys Gln Ala Arg Asn His Ser Gly Thr Thr Ile Pro Thr Leu 
                85                  90                  95      


Glu Cys Cys His Glu Asp Met Cys Asn Tyr Arg Gly Leu His Asp Val 
            100                 105                 110         


Leu Ser Pro Pro Arg Gly Glu Ala Ser Gly Gln Gly Asn Arg Tyr Gln 
        115                 120                 125             


His Asp Gly Ser Arg Asn Leu Ile Thr Lys Val Gln Glu Leu Thr Ser 
    130                 135                 140                 


Ser Lys Glu Leu Trp Phe Arg Ala Ala Val Ile Ala Val Pro Ile Ala 
145                 150                 155                 160 


Gly Gly Leu Ile Leu Val Leu Leu Ile Met Leu Ala Leu Arg Met Leu 
                165                 170                 175     


Arg Ser Glu Asn Lys Arg Leu Gln Asp Gln Arg Gln Gln Met Leu Ser 
            180                 185                 190         


Arg Leu His Tyr Ser Phe His Gly His His Ser Lys Lys Gly Gln Val 
        195                 200                 205             


Ala Lys Leu Asp Leu Glu Cys Met Val Pro Val Ser Gly His Glu Asn 
    210                 215                 220                 


Cys Cys Leu Thr Cys Asp Lys Met Arg Gln Ala Asp Leu Ser Asn Asp 
225                 230                 235                 240 


Lys Ile Leu Ser Leu Val His Trp Gly Met Tyr Ser Gly His Gly Lys 
                245                 250                 255     


Leu Glu Phe Val 
            260 


<210>  44
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Gln Leu Phe Leu Pro Leu Leu Ala Ala Leu Val Leu Ala Gln 
1               5                   10                  15      


Ala Pro Ala Ala Leu Ala Asp Val Leu Glu Gly Asp Ser Ser Glu Asp 
            20                  25                  30          


Arg Ala Phe Arg Val Arg Ile Ala Gly Asp Ala Pro Leu Gln Gly Val 
        35                  40                  45              


Leu Gly Gly Ala Leu Thr Ile Pro Cys His Val His Tyr Leu Arg Pro 
    50                  55                  60                  


Pro Pro Ser Arg Arg Ala Val Leu Gly Ser Pro Arg Val Lys Trp Thr 
65                  70                  75                  80  


Phe Leu Ser Arg Gly Arg Glu Ala Glu Val Leu Val Ala Arg Gly Val 
                85                  90                  95      


Arg Val Lys Val Asn Glu Ala Tyr Arg Phe Arg Val Ala Leu Pro Ala 
            100                 105                 110         


Tyr Pro Ala Ser Leu Thr Asp Val Ser Leu Ala Leu Ser Glu Leu Arg 
        115                 120                 125             


Pro Asn Asp Ser Gly Ile Tyr Arg Cys Glu Val Gln His Gly Ile Asp 
    130                 135                 140                 


Asp Ser Ser Asp Ala Val Glu Val Lys Val Lys Gly Val Val Phe Leu 
145                 150                 155                 160 


Tyr Arg Glu Gly Ser Ala Arg Tyr Ala Phe Ser Phe Ser Gly Ala Gln 
                165                 170                 175     


Glu Ala Cys Ala Arg Ile Gly Ala His Ile Ala Thr Pro Glu Gln Leu 
            180                 185                 190         


Tyr Ala Ala Tyr Leu Gly Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu 
        195                 200                 205             


Ser Asp Gln Thr Val Arg Tyr Pro Ile Gln Thr Pro Arg Glu Ala Cys 
    210                 215                 220                 


Tyr Gly Asp Met Asp Gly Phe Pro Gly Val Arg Asn Tyr Gly Val Val 
225                 230                 235                 240 


Asp Pro Asp Asp Leu Tyr Asp Val Tyr Cys Tyr Ala Glu Asp Leu Asn 
                245                 250                 255     


Gly Glu Leu Phe Leu Gly Asp Pro Pro Glu Lys Leu Thr Leu Glu Glu 
            260                 265                 270         


Ala Arg Ala Tyr Cys Gln Glu Arg Gly Ala Glu Ile Ala Thr Thr Gly 
        275                 280                 285             


Gln Leu Tyr Ala Ala Trp Asp Gly Gly Leu Asp His Cys Ser Pro Gly 
    290                 295                 300                 


Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Val Thr Pro Ser Gln 
305                 310                 315                 320 


Arg Cys Gly Gly Gly Leu Pro Gly Val Lys Thr Leu Phe Leu Phe Pro 
                325                 330                 335     


Asn Gln Thr Gly Phe Pro Asn Lys His Ser Arg Phe Asn Val Tyr Cys 
            340                 345                 350         


Phe Arg Asp Ser Ala Gln Pro Ser Ala Ile Pro Glu Ala Ser Asn Pro 
        355                 360                 365             


Ala Ser Asn Pro Ala Ser Asp Gly Leu Glu Ala Ile Val Thr Val Thr 
    370                 375                 380                 


Glu Thr Leu Glu Glu Leu Gln Leu Pro Gln Glu Ala Thr Glu Ser Glu 
385                 390                 395                 400 


Ser Arg Gly Ala Ile Tyr Ser Ile Pro Ile Met Glu Asp Gly Gly Gly 
                405                 410                 415     


Gly Ser Ser Thr Pro Glu Asp Pro Ala Glu Ala Pro Arg Thr Leu Leu 
            420                 425                 430         


Glu Phe Glu Thr Gln Ser Met Val Pro Pro Thr Gly Phe Ser Glu Glu 
        435                 440                 445             


Glu Gly Lys Ala Leu Glu Glu Glu Glu Lys Tyr Glu Asp Glu Glu Glu 
    450                 455                 460                 


Lys Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Asp Glu Ala Leu Trp 
465                 470                 475                 480 


Ala Trp Pro Ser Glu Leu Ser Ser Pro Gly Pro Glu Ala Ser Leu Pro 
                485                 490                 495     


Thr Glu Pro Ala Ala Gln Glu Glu Ser Leu Ser Gln Ala Pro Ala Arg 
            500                 505                 510         


Ala Val Leu Gln Pro Gly Ala Ser Pro Leu Pro Asp Gly Glu Ser Glu 
        515                 520                 525             


Ala Ser Arg Pro Pro Arg Val His Gly Pro Pro Thr Glu Thr Leu Pro 
    530                 535                 540                 


Thr Pro Arg Glu Arg Asn Leu Ala Ser Pro Ser Pro Ser Thr Leu Val 
545                 550                 555                 560 


Glu Ala Arg Glu Val Gly Glu Ala Thr Gly Gly Pro Glu Leu Ser Gly 
                565                 570                 575     


Val Pro Arg Gly Glu Ser Glu Glu Thr Gly Ser Ser Glu Gly Ala Pro 
            580                 585                 590         


Ser Leu Leu Pro Ala Thr Arg Ala Pro Glu Gly Thr Arg Glu Leu Glu 
        595                 600                 605             


Ala Pro Ser Glu Asp Asn Ser Gly Arg Thr Ala Pro Ala Gly Thr Ser 
    610                 615                 620                 


Val Gln Ala Gln Pro Val Leu Pro Thr Asp Ser Ala Ser Arg Gly Gly 
625                 630                 635                 640 


Val Ala Val Val Pro Ala Ser Gly Asp Cys Val Pro Ser Pro Cys His 
                645                 650                 655     


Asn Gly Gly Thr Cys Leu Glu Glu Glu Glu Gly Val Arg Cys Leu Cys 
            660                 665                 670         


Leu Pro Gly Tyr Gly Gly Asp Leu Cys Asp Val Gly Leu Arg Phe Cys 
        675                 680                 685             


Asn Pro Gly Trp Asp Ala Phe Gln Gly Ala Cys Tyr Lys His Phe Ser 
    690                 695                 700                 


Thr Arg Arg Ser Trp Glu Glu Ala Glu Thr Gln Cys Arg Met Tyr Gly 
705                 710                 715                 720 


Ala His Leu Ala Ser Ile Ser Thr Pro Glu Glu Gln Asp Phe Ile Asn 
                725                 730                 735     


Asn Arg Tyr Arg Glu Tyr Gln Trp Ile Gly Leu Asn Asp Arg Thr Ile 
            740                 745                 750         


Glu Gly Asp Phe Leu Trp Ser Asp Gly Val Pro Leu Leu Tyr Glu Asn 
        755                 760                 765             


Trp Asn Pro Gly Gln Pro Asp Ser Tyr Phe Leu Ser Gly Glu Asn Cys 
    770                 775                 780                 


Val Val Met Val Trp His Asp Gln Gly Gln Trp Ser Asp Val Pro Cys 
785                 790                 795                 800 


Asn Tyr His Leu Ser Tyr Thr Cys Lys Met Gly Leu Val Ser Cys Gly 
                805                 810                 815     


Pro Pro Pro Glu Leu Pro Leu Ala Gln Val Phe Gly Arg Pro Arg Leu 
            820                 825                 830         


Arg Tyr Glu Val Asp Thr Val Leu Arg Tyr Arg Cys Arg Glu Gly Leu 
        835                 840                 845             


Ala Gln Arg Asn Leu Pro Leu Ile Arg Cys Gln Glu Asn Gly Arg Trp 
    850                 855                 860                 


Glu Ala Pro Gln Ile Ser Cys Val Pro Arg Arg Pro Ala Arg Ala Leu 
865                 870                 875                 880 


His Pro Glu Glu Asp Pro Glu Gly Arg Gln Gly Arg Leu Leu Gly Arg 
                885                 890                 895     


Trp Lys Ala Leu Leu Ile Pro Pro Ser Ser Pro Met Pro Gly Pro 
            900                 905                 910     


<210>  45
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Gln Leu Phe Leu Pro Leu Leu Ala Ala Leu Val Leu Ala Gln 
1               5                   10                  15      


Ala Pro Ala Ala Leu Ala Asp Val Leu Glu Gly Asp Ser Ser Glu Asp 
            20                  25                  30          


Arg Ala Phe Arg Val Arg Ile Ala Gly Asp Ala Pro Leu Gln Gly Val 
        35                  40                  45              


Leu Gly Gly Ala Leu Thr Ile Pro Cys His Val His Tyr Leu Arg Pro 
    50                  55                  60                  


Pro Pro Ser Arg Arg Ala Val Leu Gly Ser Pro Arg Val Lys Trp Thr 
65                  70                  75                  80  


Phe Leu Ser Arg Gly Arg Glu Ala Glu Val Leu Val Ala Arg Gly Val 
                85                  90                  95      


Arg Val Lys Val Asn Glu Ala Tyr Arg Phe Arg Val Ala Leu Pro Ala 
            100                 105                 110         


Tyr Pro Ala Ser Leu Thr Asp Val Ser Leu Ala Leu Ser Glu Leu Arg 
        115                 120                 125             


Pro Asn Asp Ser Gly Ile Tyr Arg Cys Glu Val Gln His Gly Ile Asp 
    130                 135                 140                 


Asp Ser Ser Asp Ala Val Glu Val Lys Val Lys Gly Val Val Phe Leu 
145                 150                 155                 160 


Tyr Arg Glu Gly Ser Ala Arg Tyr Ala Phe Ser Phe Ser Gly Ala Gln 
                165                 170                 175     


Glu Ala Cys Ala Arg Ile Gly Ala His Ile Ala Thr Pro Glu Gln Leu 
            180                 185                 190         


Tyr Ala Ala Tyr Leu Gly Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu 
        195                 200                 205             


Ser Asp Gln Thr Val Arg Tyr Pro Ile Gln Thr Pro Arg Glu Ala Cys 
    210                 215                 220                 


Tyr Gly Asp Met Asp Gly Phe Pro Gly Val Arg Asn Tyr Gly Val Val 
225                 230                 235                 240 


Asp Pro Asp Asp Leu Tyr Asp Val Tyr Cys Tyr Ala Glu Asp Leu Asn 
                245                 250                 255     


Gly Glu Leu Phe Leu Gly Asp Pro Pro Glu Lys Leu Thr Leu Glu Glu 
            260                 265                 270         


Ala Arg Ala Tyr Cys Gln Glu Arg Gly Ala Glu Ile Ala Thr Thr Gly 
        275                 280                 285             


Gln Leu Tyr Ala Ala Trp Asp Gly Gly Leu Asp His Cys Ser Pro Gly 
    290                 295                 300                 


Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Val Thr Pro Ser Gln 
305                 310                 315                 320 


Arg Cys Gly Gly Gly Leu Pro Gly Val Lys Thr Leu Phe Leu Phe Pro 
                325                 330                 335     


Asn Gln Thr Gly Phe Pro Asn Lys His Ser Arg Phe Asn Val Tyr Cys 
            340                 345                 350         


Phe Arg Asp Ser Ala Gln Pro Ser Ala Ile Pro Glu Ala Ser Asn Pro 
        355                 360                 365             


Ala Ser Asn Pro Ala Ser Asp Gly Leu Glu Ala Ile Val Thr Val Thr 
    370                 375                 380                 


Glu Thr Leu Glu Glu Leu Gln Leu Pro Gln Glu Ala Thr Glu Ser Glu 
385                 390                 395                 400 


Ser Arg Gly Ala Ile Tyr Ser Ile Pro Ile Met Glu Asp Gly Gly Gly 
                405                 410                 415     


Gly Ser Ser Thr Pro Glu Asp Pro Ala Glu Ala Pro Arg Thr Leu Leu 
            420                 425                 430         


Glu Phe Glu Thr Gln Ser Met Val Pro Pro Thr Gly Phe Ser Glu Glu 
        435                 440                 445             


Glu Gly Lys Ala Leu Glu Glu Glu Glu Lys Tyr Glu Asp Glu Glu Glu 
    450                 455                 460                 


Lys Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Asp Glu Ala Leu Trp 
465                 470                 475                 480 


Ala Trp Pro Ser Glu Leu Ser Ser Pro Gly Pro Glu Ala Ser Leu Pro 
                485                 490                 495     


Thr Glu Pro Ala Ala Gln Glu Glu Ser Leu Ser Gln Ala Pro Ala Arg 
            500                 505                 510         


Ala Val Leu Gln Pro Gly Ala Ser Pro Leu Pro Asp Gly Glu Ser Glu 
        515                 520                 525             


Ala Ser Arg Pro Pro Arg Val His Gly Pro Pro Thr Glu Thr Leu Pro 
    530                 535                 540                 


Thr Pro Arg Glu Arg Asn Leu Ala Ser Pro Ser Pro Ser Thr Leu Val 
545                 550                 555                 560 


Glu Ala Arg Glu Val Gly Glu Ala Thr Gly Gly Pro Glu Leu Ser Gly 
                565                 570                 575     


Val Pro Arg Gly Glu Ser Glu Glu Thr Gly Ser Ser Glu Gly Ala Pro 
            580                 585                 590         


Ser Leu Leu Pro Ala Thr Arg Ala Pro Glu Gly Thr Arg Glu Leu Glu 
        595                 600                 605             


Ala Pro Ser Glu Asp Asn Ser Gly Arg Thr Ala Pro Ala Gly Thr Ser 
    610                 615                 620                 


Val Gln Ala Gln Pro Val Leu Pro Thr Asp Ser Ala Ser Arg Gly Gly 
625                 630                 635                 640 


Val Ala Val Val Pro Ala Ser Gly Asn Ser Ala Gln Gly Ser Thr Ala 
                645                 650                 655     


Leu Ser Ile Leu Leu Leu Phe Phe Pro Leu Gln Leu Trp Val Thr 
            660                 665                 670     


<210>  46
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Leu Gln Trp Thr Ala Val Ala Thr Phe Leu Tyr Ala Glu Val 
1               5                   10                  15      


Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro Lys Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val Ser Tyr Gly 
        35                  40                  45              


Asn Thr Phe Phe Val Val Leu Ile Val Ile Leu Val Leu Leu Val Ile 
    50                  55                  60                  


Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Thr Glu Lys Val 
65                  70                  75                  80  


Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His Met Lys Leu 
                85                  90                  95      


Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Ser Phe Leu Leu Arg Arg Leu Val Thr Leu Ile Ser Gln Gln Ala Thr 
        115                 120                 125             


Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu Ser Ala Ser 
    130                 135                 140                 


Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu Lys Lys Gly 
145                 150                 155                 160 


Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala Glu Val Lys 
                165                 170                 175     


Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp Leu Gln Lys Leu Lys 
            180                 185                 190         


Asp Glu Leu Ala Ser Thr Lys Gln Lys Leu Glu Lys Ala Glu Asn Gln 
        195                 200                 205             


Val Leu Ala Met Arg Lys Gln Ser Glu Gly Leu Thr Lys Glu Tyr Asp 
    210                 215                 220                 


Arg Leu Leu Glu Glu His Ala Lys Leu Gln Ala Ala Val Asp Gly Pro 
225                 230                 235                 240 


Met Asp Lys Lys Glu Glu 
                245     


<210>  47
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gly Ala Glu Ala Ser Ser Ser Trp Cys Pro Gly Thr Ala Leu Pro 
1               5                   10                  15      


Glu Glu Arg Leu Ser Val Lys Arg Ala Ser Glu Ile Ser Gly Phe Leu 
            20                  25                  30          


Gly Gln Gly Ser Ser Gly Glu Ala Ala Leu Asp Val Leu Thr His Val 
        35                  40                  45              


Leu Glu Gly Ala Gly Asn Lys Leu Thr Ser Ser Cys Gly Lys Pro Ser 
    50                  55                  60                  


Ser Asn Arg Met Ser Leu Gln Trp Thr Ala Val Ala Thr Phe Leu Tyr 
65                  70                  75                  80  


Ala Glu Val Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro 
                85                  90                  95      


Lys Arg Trp Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val 
            100                 105                 110         


Ser Tyr Gly Asn Thr Phe Phe Val Val Leu Ile Val Ile Leu Val Leu 
        115                 120                 125             


Leu Val Ile Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Thr 
    130                 135                 140                 


Glu Lys Val Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His 
145                 150                 155                 160 


Met Lys Leu Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser 
                165                 170                 175     


Leu Leu Leu Ser Phe Leu Leu Arg Arg Leu Val Thr Leu Ile Ser Gln 
            180                 185                 190         


Gln Ala Thr Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu 
        195                 200                 205             


Ser Ala Ser Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu 
    210                 215                 220                 


Lys Lys Gly Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala 
225                 230                 235                 240 


Glu Val Lys Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp Leu Gln 
                245                 250                 255     


Lys Leu Lys Asp Glu Leu Ala Ser Thr Lys Gln Lys Leu Glu Lys Ala 
            260                 265                 270         


Glu Asn Gln Val Leu Ala Met Arg Lys Gln Ser Glu Gly Leu Thr Lys 
        275                 280                 285             


Glu Tyr Asp Arg Leu Leu Glu Glu His Ala Lys Leu Gln Ala Ala Val 
    290                 295                 300                 


Asp Gly Pro Met Asp Lys Lys Glu Glu 
305                 310             


<210>  48
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Leu Gln Trp Thr Ala Val Ala Thr Phe Leu Tyr Ala Glu Val 
1               5                   10                  15      


Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro Lys Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val Ser Tyr Gly 
        35                  40                  45              


Asn Thr Phe Phe Val Val Leu Ile Val Ile Leu Val Leu Leu Val Ile 
    50                  55                  60                  


Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Thr Glu Lys Val 
65                  70                  75                  80  


Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His Met Lys Leu 
                85                  90                  95      


Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Ser Phe Leu Leu Arg Arg Leu Val Thr Leu Ile Ser Gln Gln Ala Thr 
        115                 120                 125             


Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu Ser Ala Ser 
    130                 135                 140                 


Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu Lys Lys Gly 
145                 150                 155                 160 


Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala Glu Val Lys 
                165                 170                 175     


Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp Leu Gln Lys Leu Lys 
            180                 185                 190         


Asp Glu Leu Ala Ser Thr Lys Gln Lys Leu Glu Lys Ala Glu Asn Gln 
        195                 200                 205             


Val Leu Ala Met Arg Lys Gln Ser Glu Gly Leu Thr Lys Glu Tyr Asp 
    210                 215                 220                 


Arg Leu Leu Glu Glu His Ala Lys Leu Gln Ala Ala Val Asp Gly Pro 
225                 230                 235                 240 


Met Asp Lys Lys Glu Glu 
                245     


<210>  49
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ser Leu Gln Trp Thr Ala Val Ala Thr Phe Leu Tyr Ala Glu Val 
1               5                   10                  15      


Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro Lys Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val Ser Tyr Gly 
        35                  40                  45              


Asn Thr Phe Phe Val Val Leu Ile Val Ile Leu Val Leu Leu Val Ile 
    50                  55                  60                  


Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Thr Glu Lys Val 
65                  70                  75                  80  


Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His Met Lys Leu 
                85                  90                  95      


Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Ser Phe Leu Leu Arg Arg Leu Val Thr Leu Ile Ser Gln Gln Ala Thr 
        115                 120                 125             


Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu Ser Ala Ser 
    130                 135                 140                 


Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu Lys Lys Gly 
145                 150                 155                 160 


Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala Glu Val Lys 
                165                 170                 175     


Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp Leu Gln Lys Leu Lys 
            180                 185                 190         


Asp Glu Leu Ala Ser Thr Lys Gln Lys Leu Glu Lys Ala Glu Asn Gln 
        195                 200                 205             


Val Leu Ala Met Arg Lys Gln Ser Glu Gly Leu Thr Lys Glu Tyr Asp 
    210                 215                 220                 


Arg Leu Leu Glu Glu His Ala Lys Leu Gln Ala Ala Val Asp Gly Pro 
225                 230                 235                 240 


Met Asp Lys Lys Glu Glu 
                245     


<210>  50
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Phe Leu Ile Ser Ser Ser Val His Gly Ser Asp Glu His Gly Arg 
1               5                   10                  15      


Leu Leu Arg Arg Thr Leu Met Arg Tyr Val Asn Leu Thr Ser Leu Leu 
            20                  25                  30          


Ile Phe Arg Ser Val Ser Thr Ala Val Tyr Lys Arg Phe Pro Thr Met 
        35                  40                  45              


Asp His Val Val Glu Ala Gly Phe Met Thr Thr Asp Glu Arg Lys Leu 
    50                  55                  60                  


Phe Asn His Leu Lys Ser Pro His Leu Lys Tyr Trp Val Pro Phe Ile 
65                  70                  75                  80  


Trp Phe Gly Asn Leu Ala Thr Lys Ala Arg Asn Glu Gly Arg Ile Arg 
                85                  90                  95      


Asp Ser Val Asp Leu Gln Ser Leu Met Thr Glu Met Asn Arg Tyr Arg 
            100                 105                 110         


Ser Trp Cys Ser Leu Leu Phe Gly Tyr Asp Trp Val Gly Ile Pro Leu 
        115                 120                 125             


Val Tyr Thr Gln Val Val Thr Leu Ala Val Tyr Thr Phe Phe Phe Ala 
    130                 135                 140                 


Cys Leu Ile Gly Arg Gln Phe Leu Asp Pro Thr Lys Gly Tyr Ala Gly 
145                 150                 155                 160 


His Asp Leu Asp Leu Tyr Ile Pro Ile Phe Thr Leu Leu Gln Phe Phe 
                165                 170                 175     


Phe Tyr Ala Gly Trp Leu Lys Val Ala Glu Gln Leu Ile Asn Pro Phe 
            180                 185                 190         


Gly Glu Asp Asp Asp Asp Phe Glu Thr Asn Trp Cys Ile Asp Arg Asn 
        195                 200                 205             


Leu Gln Val Ser Leu Leu Ala Val Asp Glu Met His Met Ser Leu Pro 
    210                 215                 220                 


Lys Met Lys Lys Asp Ile Tyr Trp Asp Asp Ser Ala Ala Arg Pro Pro 
225                 230                 235                 240 


Tyr Thr Leu Ala Ala Ala Asp Tyr Cys Ile Pro Ser Phe Leu Gly Ser 
                245                 250                 255     


Thr Val Gln Met Gly Leu Ser Gly Ser Asp Phe Pro Asp Glu Glu Trp 
            260                 265                 270         


Leu Trp Asp Tyr Glu Lys His Gly His Arg His Ser Met Ile Arg Arg 
        275                 280                 285             


Val Lys Arg Phe Leu Ser Ala His Glu His Pro Ser Ser Pro Arg Arg 
    290                 295                 300                 


Arg Ser Tyr Arg Arg Gln Thr Ser Asp Ser Ser Met Phe Leu Pro Arg 
305                 310                 315                 320 


Asp Asp Leu Ser Pro Ala Arg Asp Leu Leu Asp Val Pro Ser Arg Asn 
                325                 330                 335     


Pro Pro Arg Ala Ser Pro Thr Trp Lys Lys Ser Cys Phe Pro Glu Gly 
            340                 345                 350         


Ser Pro Thr Leu His Phe Ser Met Gly Glu Leu Ser Thr Ile Arg Glu 
        355                 360                 365             


Thr Ser Gln Thr Ser Thr Leu Gln Ser Leu Thr Pro Gln Ser Ser Val 
    370                 375                 380                 


Arg Thr Ser Pro Ile Lys Met Pro Leu Val Pro Glu Val Leu Ile Thr 
385                 390                 395                 400 


Ala Ala Glu Ala Pro Val Pro Thr Ser Gly Gly Tyr His His Asp Ser 
                405                 410                 415     


Ala Thr Ser Ile Leu Ser Ser Glu Phe Thr Gly Val Gln Pro Ser Lys 
            420                 425                 430         


Thr Glu Gln Gln Gln Gly Pro Met Gly Ser Ile Leu Ser Pro Ser Glu 
        435                 440                 445             


Lys Glu Thr Pro Pro Gly Gly Pro Ser Pro Gln Thr Val Ser Ala Ser 
    450                 455                 460                 


Ala Glu Glu Asn Ile Phe Asn Cys Glu Glu Asp Pro Gly Asp Thr Phe 
465                 470                 475                 480 


Leu Lys Arg Trp Ser Leu Pro Gly Phe Leu Gly Ser Ser His Thr Ser 
                485                 490                 495     


Leu Gly Asn Leu Ser Pro Asp Pro Met Ser Ser Gln Pro Ala Leu Leu 
            500                 505                 510         


Ile Asp Thr Glu Thr Ser Ser Glu Ile Ser Gly Ile Asn Ile Val Ala 
        515                 520                 525             


Gly Ser Arg Val Ser Ser Asp Met Leu Tyr Leu Met Glu Asn Leu Asp 
    530                 535                 540                 


Thr Lys Glu Thr Asp Ile Ile Glu Leu Asn Lys Glu Thr Glu Glu Ser 
545                 550                 555                 560 


Pro Lys 
        


<210>  51
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Thr Val Thr Tyr Ser Ser Lys Val Ala Asn Ala Thr Phe Phe Gly 
1               5                   10                  15      


Phe His Arg Leu Leu Leu Lys Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Tyr Arg Glu Phe Ile Val Phe Ala Val Leu Tyr Thr Ala Ile Ser Leu 
        35                  40                  45              


Val Tyr Arg Leu Leu Leu Thr Gly Val Gln Lys Arg Tyr Phe Glu Lys 
    50                  55                  60                  


Leu Ser Ile Tyr Cys Asp Arg Tyr Ala Glu Gln Ile Pro Val Thr Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Asn Arg Trp Trp Asn Gln 
                85                  90                  95      


Phe Val Asn Leu Pro Trp Pro Asp Arg Leu Met Phe Leu Ile Ser Ser 
            100                 105                 110         


Ser Val His Gly Ser Asp Glu His Gly Arg Leu Leu Arg Arg Thr Leu 
        115                 120                 125             


Met Arg Tyr Val Asn Leu Thr Ser Leu Leu Ile Phe Arg Ser Val Ser 
    130                 135                 140                 


Thr Ala Val Tyr Lys Arg Phe Pro Thr Met Asp His Val Val Glu Ala 
145                 150                 155                 160 


Gly Phe Met Thr Thr Asp Glu Arg Lys Leu Phe Asn His Leu Lys Ser 
                165                 170                 175     


Pro His Leu Lys Tyr Trp Val Pro Phe Ile Trp Phe Gly Asn Leu Ala 
            180                 185                 190         


Thr Lys Ala Arg Asn Glu Gly Arg Ile Arg Asp Ser Val Asp Leu Gln 
        195                 200                 205             


Ser Leu Met Thr Glu Met Asn Arg Tyr Arg Ser Trp Cys Ser Leu Leu 
    210                 215                 220                 


Phe Gly Tyr Asp Trp Val Gly Ile Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Leu Ala Val Tyr Thr Phe Phe Phe Ala Cys Leu Ile Gly Arg Gln 
                245                 250                 255     


Phe Leu Asp Pro Thr Lys Gly Tyr Ala Gly His Asp Leu Asp Leu Tyr 
            260                 265                 270         


Ile Pro Ile Phe Thr Leu Leu Gln Phe Phe Phe Tyr Ala Gly Trp Leu 
        275                 280                 285             


Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp 
    290                 295                 300                 


Phe Glu Thr Asn Trp Cys Ile Asp Arg Asn Leu Gln Val Ser Leu Leu 
305                 310                 315                 320 


Ala Val Asp Glu Met His Met Ser Leu Pro Lys Met Lys Lys Asp Ile 
                325                 330                 335     


Tyr Trp Asp Asp Ser Ala Ala Arg Pro Pro Tyr Thr Leu Ala Ala Ala 
            340                 345                 350         


Asp Tyr Cys Ile Pro Ser Phe Leu Gly Ser Thr Val Gln Met Gly Lys 
        355                 360                 365             


Gln Met Pro Lys Asn Glu Trp Lys Met Glu Asp Ile Lys Ile Pro Leu 
    370                 375                 380                 


Pro Gln Pro Gln Phe Gln Cys Ala Lys Ser Asp Pro Gly Gly 
385                 390                 395             


<210>  52
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Phe Leu Ile Ser Ser Ser Val His Gly Ser Asp Glu His Gly Arg 
1               5                   10                  15      


Leu Leu Arg Arg Thr Leu Met Arg Tyr Val Asn Leu Thr Ser Leu Leu 
            20                  25                  30          


Ile Phe Arg Ser Val Ser Thr Ala Val Tyr Lys Arg Phe Pro Thr Met 
        35                  40                  45              


Asp His Val Val Glu Ala Glu Arg Thr Gly Met Lys Pro Ile Leu Pro 
    50                  55                  60                  


Ser Ser Phe Glu Met Gln Ser Phe 
65                  70          


<210>  53
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Phe Leu Ile Ser Ser Ser Val His Gly Ser Asp Glu His Gly Arg 
1               5                   10                  15      


Leu Leu Arg Arg Thr Leu Met Arg Tyr Val Asn Leu Thr Ser Leu Leu 
            20                  25                  30          


Ile Phe Arg Ser Val Ser Thr Ala Val Tyr Lys Arg Phe Pro Thr Met 
        35                  40                  45              


Asp His Val Val Glu Ala Glu Arg Thr Gly Met Lys Pro Ile Leu Pro 
    50                  55                  60                  


Ser Ser Phe Glu Met Gln Ser Phe 
65                  70          


<210>  54
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Thr Val Thr Tyr Ser Ser Lys Val Ala Asn Ala Thr Phe Phe Gly 
1               5                   10                  15      


Phe His Arg Leu Leu Leu Lys Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Tyr Arg Glu Phe Ile Val Phe Ala Val Leu Tyr Thr Ala Ile Ser Leu 
        35                  40                  45              


Val Tyr Arg Leu Leu Leu Thr Gly Val Gln Lys Arg Tyr Phe Glu Lys 
    50                  55                  60                  


Leu Ser Ile Tyr Cys Asp Arg Tyr Ala Glu Gln Ile Pro Val Thr Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Asn Arg Trp Trp Asn Gln 
                85                  90                  95      


Phe Val Asn Leu Pro Trp Pro Asp Arg Leu Met Phe Leu Ile Ser Ser 
            100                 105                 110         


Ser Val His Gly Ser Asp Glu His Gly Arg Leu Leu Arg Arg Thr Leu 
        115                 120                 125             


Met Arg Tyr Val Asn Leu Thr Ser Leu Leu Ile Phe Arg Ser Val Ser 
    130                 135                 140                 


Thr Ala Val Tyr Lys Arg Phe Pro Thr Met Asp His Val Val Glu Ala 
145                 150                 155                 160 


Gly Phe Met Thr Thr Asp Glu Arg Lys Leu Phe Asn His Leu Lys Ser 
                165                 170                 175     


Pro His Leu Lys Tyr Trp Val Pro Phe Ile Trp Phe Gly Asn Leu Ala 
            180                 185                 190         


Thr Lys Ala Arg Asn Glu Gly Arg Ile Arg Asp Ser Val Asp Leu Gln 
        195                 200                 205             


Ser Leu Met Thr Glu Met Asn Arg Tyr Arg Ser Trp Cys Ser Leu Leu 
    210                 215                 220                 


Phe Gly Tyr Asp Trp Val Gly Ile Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Leu Ala Val Tyr Thr Phe Phe Phe Ala Cys Leu Ile Gly Arg Gln 
                245                 250                 255     


Phe Leu Asp Pro Thr Lys Gly Tyr Ala Gly His Asp Leu Asp Leu Tyr 
            260                 265                 270         


Ile Pro Ile Phe Thr Leu Leu Gln Phe Phe Phe Tyr Ala Gly Trp Leu 
        275                 280                 285             


Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp 
    290                 295                 300                 


Phe Glu Thr Asn Trp Cys Ile Asp Arg Asn Leu Gln Val Ser Leu Leu 
305                 310                 315                 320 


Ala Val Asp Glu Met His Met Ser Leu Pro Lys Met Lys Lys Asp Ile 
                325                 330                 335     


Tyr Trp Asp Asp Ser Ala Ala Arg Pro Pro Tyr Thr Leu Ala Ala Ala 
            340                 345                 350         


Asp Tyr Cys Ile Pro Ser Phe Leu Gly Ser Thr Val Gln Met Gly Leu 
        355                 360                 365             


Ser Gly Ser Asp Phe Pro Asp Glu Glu Trp Leu Trp Asp Tyr Glu Lys 
    370                 375                 380                 


His Gly His Arg His Ser Met Ile Arg Arg Val Lys Arg Phe Leu Ser 
385                 390                 395                 400 


Ala His Glu His Pro Ser Ser Pro Arg Arg Arg Ser Tyr Arg Arg Gln 
                405                 410                 415     


Thr Ser Asp Ser Ser Met Phe Leu Pro Arg Asp Asp Leu Ser Pro Ala 
            420                 425                 430         


Arg Asp Leu Leu Asp Val Pro Ser Arg Asn Pro Pro Arg Ala Ser Pro 
        435                 440                 445             


Thr Trp Lys Lys Ser Cys Phe Pro Glu Gly Ser Pro Thr Leu His Phe 
    450                 455                 460                 


Ser Met Gly Glu Leu Ser Thr Ile Arg Glu Thr Ser Gln Thr Ser Thr 
465                 470                 475                 480 


Leu Gln Ser Leu Thr Pro Gln Ser Ser Val Arg Thr Ser Pro Ile Lys 
                485                 490                 495     


Met Pro Leu Val Pro Glu Val Leu Ile Thr Ala Ala Glu Ala Pro Val 
            500                 505                 510         


Pro Thr Ser Gly Gly Tyr His His Asp Ser Ala Thr Ser Ile Leu Ser 
        515                 520                 525             


Ser Glu Phe Thr Gly Val Gln Pro Ser Lys Thr Glu Gln Gln Gln Gly 
    530                 535                 540                 


Pro Met Gly Ser Ile Leu Ser Pro Ser Glu Lys Glu Thr Pro Pro Gly 
545                 550                 555                 560 


Gly Pro Ser Pro Gln Thr Val Ser Ala Ser Ala Glu Glu Asn Ile Phe 
                565                 570                 575     


Asn Cys Glu Glu Asp Pro Gly Asp Thr Phe Leu Lys Arg Trp Ser Leu 
            580                 585                 590         


Pro Gly Phe Leu Gly Ser Ser His Thr Ser Leu Gly Asn Leu Ser Pro 
        595                 600                 605             


Asp Pro Met Ser Ser Gln Pro Ala Leu Leu Ile Asp Thr Glu Thr Ser 
    610                 615                 620                 


Ser Glu Ile Ser Gly Ile Asn Ile Val Ala Gly Ser Arg Val Ser Ser 
625                 630                 635                 640 


Asp Met Leu Tyr Leu Met Glu Asn Leu Asp Thr Lys Glu Thr Asp Ile 
                645                 650                 655     


Ile Glu Leu Asn Lys Glu Thr Glu Glu Ser Pro Lys 
            660                 665             


<210>  55
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Thr Thr Asp Glu Arg Lys Leu Phe Asn His Leu Lys Ser Pro His 
1               5                   10                  15      


Leu Lys Tyr Trp Val Pro Phe Ile Trp Phe Gly Asn Leu Ala Thr Lys 
            20                  25                  30          


Ala Arg Asn Glu Gly Arg Ile Arg Asp Ser Val Asp Leu Gln Ser Leu 
        35                  40                  45              


Met Thr Glu Met Asn Arg Tyr Arg Ser Trp Cys Ser Leu Leu Phe Gly 
    50                  55                  60                  


Tyr Asp Trp Val Gly Ile Pro Leu Val Tyr Thr Gln Val Ala Glu Gln 
65                  70                  75                  80  


Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp Phe Glu Thr Asn Trp 
                85                  90                  95      


Cys Ile Asp Arg Asn Leu Gln Val Ser Leu Leu Ala Val Asp Glu Met 
            100                 105                 110         


His Met Ser Leu Pro Lys Met Lys Lys Asp Ile Tyr Trp Asp Asp Ser 
        115                 120                 125             


Ala Ala Arg Pro Pro Tyr Thr Leu Ala Ala Ala Asp Tyr Cys Ile Pro 
    130                 135                 140                 


Ser Phe Leu Gly Ser Thr Val Gln Met Gly Leu Ser Gly Ser Asp Phe 
145                 150                 155                 160 


Pro Asp Glu Glu Trp Leu Trp Asp Tyr Glu Lys His Gly His Arg His 
                165                 170                 175     


Ser Met Ile Arg Arg Val Lys Arg Phe Leu Ser Ala His Glu His Pro 
            180                 185                 190         


Ser Ser Pro Arg Arg Arg Ser Tyr Arg Arg Gln Thr Ser Asp Ser Ser 
        195                 200                 205             


Met Phe Leu Pro Arg Asp Asp Leu Ser Pro Ala Arg Asp Leu Leu Asp 
    210                 215                 220                 


Val Pro Ser Arg Asn Pro Pro Arg Ala Ser Pro Thr Trp Lys Lys Ser 
225                 230                 235                 240 


Cys Phe Pro Glu Gly Ser Pro Thr Leu His Phe Ser Met Gly Glu Leu 
                245                 250                 255     


Ser Thr Ile Arg Glu Thr Ser Gln Thr Ser Thr Leu Gln Ser Leu Thr 
            260                 265                 270         


Pro Gln Ser Ser Val Arg Thr Ser Pro Ile Lys Met Pro Leu Val Pro 
        275                 280                 285             


Glu Val Leu Ile Thr Ala Ala Glu Ala Pro Val Pro Thr Ser Gly Gly 
    290                 295                 300                 


Tyr His His Asp Ser Ala Thr Ser Ile Leu Ser Ser Glu Phe Thr Gly 
305                 310                 315                 320 


Val Gln Pro Ser Lys Thr Glu Gln Gln Gln Gly Pro Met Gly Ser Ile 
                325                 330                 335     


Leu Ser Pro Ser Glu Lys Glu Thr Pro Pro Gly Gly Pro Ser Pro Gln 
            340                 345                 350         


Thr Val Ser Ala Ser Ala Glu Glu Asn Ile Phe Asn Cys Glu Glu Asp 
        355                 360                 365             


Pro Gly Asp Thr Phe Leu Lys Arg Trp Ser Leu Pro Gly Phe Leu Gly 
    370                 375                 380                 


Ser Ser His Thr Ser Leu Gly Asn Leu Ser Pro Asp Pro Met Ser Ser 
385                 390                 395                 400 


Gln Pro Ala Leu Leu Ile Asp Thr Glu Thr Ser Ser Glu Ile Ser Gly 
                405                 410                 415     


Ile Asn Ile Val Ala Gly Ser Arg Val Ser Ser Asp Met Leu Tyr Leu 
            420                 425                 430         


Met Glu Asn Leu Asp Thr Lys Glu Thr Asp Ile Ile Glu Leu Asn Lys 
        435                 440                 445             


Glu Thr Glu Glu Ser Pro Lys 
    450                 455 


<210>  56
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Glu Glu Pro Gln Lys Ser Tyr Val Asn Thr Met Asp Leu Glu Arg 
1               5                   10                  15      


Asp Glu Pro Leu Lys Ser Thr Gly Pro Gln Ile Ser Val Ser Glu Phe 
            20                  25                  30          


Ser Cys His Cys Cys Tyr Asp Ile Leu Val Asn Pro Thr Thr Leu Asn 
        35                  40                  45              


Cys Gly His Ser Phe Cys Arg His Cys Leu Ala Leu Trp Trp Ala Ser 
    50                  55                  60                  


Ser Lys Lys Thr Glu Cys Pro Glu Cys Arg Glu Lys Trp Glu Gly Phe 
65                  70                  75                  80  


Pro Lys Val Ser Ile Leu Leu Arg Asp Ala Ile Glu Lys Leu Phe Pro 
                85                  90                  95      


Asp Ala Ile Arg Leu Arg Phe Glu Asp Ile Gln Gln Asn Asn Asp Ile 
            100                 105                 110         


Val Gln Ser Leu Ala Ala Phe Gln Lys Tyr Gly Asn Asp Gln Ile Pro 
        115                 120                 125             


Leu Ala Pro Asn Thr Gly Arg Ala Asn Gln Gln Met Gly Gly Gly Phe 
    130                 135                 140                 


Phe Ser Gly Val Leu Thr Ala Leu Thr Gly Val Ala Val Val Leu Leu 
145                 150                 155                 160 


Val Tyr His Trp Ser Ser Arg Glu Ser Glu His Asp Leu Leu Val His 
                165                 170                 175     


Lys Ala Val Ala Lys Trp Thr Ala Glu Glu Val Val Leu Trp Leu Glu 
            180                 185                 190         


Gln Leu Gly Pro Trp Ala Ser Leu Tyr Arg Glu Arg Phe Leu Ser Glu 
        195                 200                 205             


Arg Val Asn Gly Arg Leu Leu Leu Thr Leu Thr Glu Glu Glu Phe Ser 
    210                 215                 220                 


Lys Thr Pro Tyr Thr Ile Glu Asn Ser Ser His Arg Arg Ala Ile Leu 
225                 230                 235                 240 


Met Glu Leu Glu Arg Val Lys Ala Leu Gly Val Lys Pro Pro Gln Asn 
                245                 250                 255     


Leu Trp Glu Tyr Lys Ala Val Asn Pro Gly Arg Ser Leu Phe Leu Leu 
            260                 265                 270         


Tyr Ala Leu Lys Ser Ser Pro Arg Leu Ser Leu Leu Tyr Leu Tyr Leu 
        275                 280                 285             


Phe Asp Tyr Thr Asp Thr Phe Leu Pro Phe Ile His Thr Ile Cys Pro 
    290                 295                 300                 


Leu Gln Glu Asp Ser Ser Gly Glu Asp Ile Val Thr Lys Leu Leu Asp 
305                 310                 315                 320 


Leu Lys Glu Pro Thr Trp Lys Gln Trp Arg Glu Phe Leu Val Lys Tyr 
                325                 330                 335     


Ser Phe Leu Pro Tyr Gln Leu Ile Ala Glu Phe Ala Trp Asp Trp Leu 
            340                 345                 350         


Glu Val His Tyr Trp Thr Ser Arg Phe Leu Ile Ile Asn Ala Met Leu 
        355                 360                 365             


Leu Ser Val Leu Glu Leu Phe Ser Phe Trp Arg Ile Trp Ser Arg Ser 
    370                 375                 380                 


Glu Leu Lys Thr Val Pro Gln Arg Met Trp Ser His Phe Trp Lys Val 
385                 390                 395                 400 


Ser Thr Gln Gly Leu Phe Val Ala Met Phe Trp Pro Leu Ile Pro Gln 
                405                 410                 415     


Phe Val Cys Asn Cys Leu Phe Tyr Trp Ala Leu Tyr Phe Asn Pro Ile 
            420                 425                 430         


Ile Asn Ile Asp Leu Val Val Lys Glu Leu Arg Arg Leu Glu Thr Gln 
        435                 440                 445             


Val Leu 
    450 


<210>  57
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Met Gln Arg Lys Pro Thr Ile 
65                  70                  75                  80  


Arg Arg Lys Asn Leu Arg Lys Leu Arg Arg Lys Cys Ala Val Pro Ser 
                85                  90                  95      


Ser Ser Trp Leu Pro Trp Ile Glu Ala Ser Gly Arg Ser Cys Leu Val 
            100                 105                 110         


Pro Glu Trp Leu His His Phe Gln Gly Leu Phe Pro Gly Ala Thr Ser 
        115                 120                 125             


Leu Pro Val Gly Pro Leu Ala Met Ser 
    130                 135         


<210>  58
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Gly Pro Gly Thr Val Ala 
65                  70                  75                  80  


Tyr Ala Cys Asn Thr Ser Thr Leu Gly Gly Arg Gly Gly Arg Ile Thr 
                85                  90                  95      


Arg Glu Glu His Lys Lys His Ser Ser Gly Cys Ala Phe Leu Ser Val 
            100                 105                 110         


Lys Lys Gln Phe Glu Glu Leu Thr Leu Gly Glu Phe Leu Lys Leu Asp 
        115                 120                 125             


Arg Glu Arg Ala Lys Asn Lys Ile Ala Lys Glu Thr Asn Asn Lys Lys 
    130                 135                 140                 


Lys Glu Phe Glu Glu Thr Ala Glu Lys Val Arg Arg Ala Ile Glu Gln 
145                 150                 155                 160 


Leu Ala Ala Met Asp 
                165 


<210>  59
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  60
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Trp Thr Ala Leu Val Leu Ile Trp Ile Phe Ser Leu Ser Leu Ser 
1               5                   10                  15      


Glu Ser His Ala Ala Ser Asn Asp Pro Arg Asn Phe Val Pro Asn Lys 
            20                  25                  30          


Met Trp Lys Gly Leu Val Lys Arg Asn Ala Ser Val Glu Thr Val Asp 
        35                  40                  45              


Asn Lys Thr Ser Glu Asp Val Thr Met Ala Ala Ala Ser Pro Val Thr 
    50                  55                  60                  


Leu Thr Lys Gly Thr Ser Ala Ala His Leu Asn Ser Met Glu Val Thr 
65                  70                  75                  80  


Thr Glu Asp Thr Ser Arg Thr Asp Ala Tyr Glu Ser Tyr Lys Lys Lys 
                85                  90                  95      


Asp Tyr Thr Gln Val Asp Tyr Leu Ile Asn Gly Met Tyr Ala Asp Ser 
            100                 105                 110         


Glu Met 
        


<210>  61
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Trp Thr Ala Leu Val Leu Ile Trp Ile Phe Ser Leu Ser Leu Ser 
1               5                   10                  15      


Glu Ser His Ala Ala Ser Asn Asp Pro Arg Asn Phe Val Pro Asn Lys 
            20                  25                  30          


Met Trp Lys Gly Leu Val Lys Arg Asn Ala Ser Val Glu Thr Val Asp 
        35                  40                  45              


Asn Lys Thr Ser Glu Asp Val Thr Met Ala Ala Ala Ser Pro Val Thr 
    50                  55                  60                  


Leu Thr Lys Gly Thr Ser Ala Ala His Leu Asn Ser Met Glu Val Thr 
65                  70                  75                  80  


Thr Glu Asp Thr Ser Arg Thr Asp Val Ser Glu Pro Ala Thr Ser Gly 
                85                  90                  95      


Gly Ala Ala Asp Gly Val Thr Ser Ile Ala Pro Thr Ala Val Ala Ser 
            100                 105                 110         


Ser Thr Thr Ala Ala Ser Ile Thr Thr Ala Ala Ser Ser Met Thr Val 
        115                 120                 125             


Ala Ser Ser Ala Pro Thr Thr Ala Ala Ser Ser Thr Thr Val Ala Ser 
    130                 135                 140                 


Ile Ala Pro Thr Thr Ala Ala Ser Ser Met Thr Ala Ala Ser Ser Thr 
145                 150                 155                 160 


Pro Met Thr Leu Ala Leu Pro Ala Pro Thr Ser Thr Ser Thr Gly Arg 
                165                 170                 175     


Thr Pro Ser Thr Thr Ala Thr Gly His Pro Ser Leu Ser Thr Ala Leu 
            180                 185                 190         


Ala Gln Val Pro Lys Ser Ser Ala Leu Pro Arg Thr Ala Thr Leu Ala 
        195                 200                 205             


Thr Leu Ala Thr Arg Ala Gln Thr Val Ala Thr Thr Ala Asn Thr Ser 
    210                 215                 220                 


Ser Pro Met Ser Thr Arg Pro Ser Pro Ser Lys His Met Pro Ser Asp 
225                 230                 235                 240 


Thr Ala Ala Ser Pro Val Pro Pro Met Arg Pro Gln Ala Gln Gly Pro 
                245                 250                 255     


Ile Ser Gln Val Ser Val Asp Gln Pro Val Val Asn Thr Thr Asn Lys 
            260                 265                 270         


Ser Thr Pro Met Pro Ser Asn Thr Thr Pro Glu Pro Ala Pro Thr Pro 
        275                 280                 285             


Thr Val Val Thr Thr Thr Lys Ala Gln Ala Arg Glu Pro Thr Ala Ser 
    290                 295                 300                 


Pro Val Pro Val Pro His Thr Ser Pro Ile Pro Glu Met Glu Ala Met 
305                 310                 315                 320 


Ser Pro Thr Thr Gln Pro Ser Pro Met Pro Tyr Thr Gln Arg Ala Ala 
                325                 330                 335     


Gly Pro Gly Thr Ser Gln Ala Pro Glu Gln Val Glu Thr Glu Ala Thr 
            340                 345                 350         


Pro Gly Thr Asp Ser Thr Gly Pro Thr Pro Arg Ser Ser Gly Gly Thr 
        355                 360                 365             


Lys Met Pro Ala Thr Asp Ser Cys Gln Pro Ser Thr Gln Gly Gln Tyr 
    370                 375                 380                 


Met Val Val Thr Thr Glu Pro Leu Thr Gln Ala Val Val Asp Lys Thr 
385                 390                 395                 400 


Leu Leu Leu Val Val Leu Leu Leu Gly Val Thr Leu Phe Ile Thr Val 
                405                 410                 415     


Leu Val Leu Phe Ala Leu Gln Ala Tyr Glu Ser Tyr Lys Lys Lys Asp 
            420                 425                 430         


Tyr Thr Gln Val Asp Tyr Leu Ile Asn Gly Met Tyr Ala Asp Ser Glu 
        435                 440                 445             


Met 
    


<210>  62
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Asn Glu Thr Asn Lys Thr Leu Val Gly Pro Ser Glu Leu Pro Thr 
1               5                   10                  15      


Ala Ser Ala Val Ala Pro Gly Pro Gly Thr Gly Ala Arg Ala Trp Pro 
            20                  25                  30          


Val Leu Val Gly Phe Val Leu Gly Ala Val Val Leu Ser Leu Leu Ile 
        35                  40                  45              


Ala Leu Ala Ala Lys Cys His Leu Cys Arg Arg Tyr His Ala Ser Tyr 
    50                  55                  60                  


Arg His Arg Pro Leu Pro Glu Thr Gly Arg Gly Gly Arg Pro Gln Val 
65                  70                  75                  80  


Ala Glu Asp Glu Asp Asp Asp Gly Phe Ile Glu Asp Asn Tyr Ile Gln 
                85                  90                  95      


Pro Gly Thr Gly Glu Leu Gly Thr Glu Gly Ser Arg Asp His Phe Ser 
            100                 105                 110         


Leu 
    


<210>  63
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Asn Glu Thr Asn Lys Thr Leu Val Gly Pro Ser Glu Leu Pro Thr 
1               5                   10                  15      


Ala Ser Ala Val Ala Pro Gly Pro Gly Thr Gly Ala Arg Ala Trp Pro 
            20                  25                  30          


Val Leu Val Gly Phe Val Leu Gly Ala Val Val Leu Ser Leu Leu Ile 
        35                  40                  45              


Ala Leu Ala Ala Lys Cys His Leu Cys Arg Arg Tyr His Ala Ser Tyr 
    50                  55                  60                  


Arg His Arg Pro Leu Pro Glu Thr Gly Arg Gly Gly Arg Pro Gln Val 
65                  70                  75                  80  


Ala Glu Asp Glu Asp Asp Asp Gly Phe Ile Glu Asp Asn Tyr Ile Gln 
                85                  90                  95      


Pro Gly Thr Gly Glu Leu Gly Thr Glu Gly Ser Arg Asp His Phe Ser 
            100                 105                 110         


Leu 
    


<210>  64
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  65
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  66
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  67
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile Leu Lys 
1               5                   10                  15      


Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys Tyr Gly 
            20                  25                  30          


Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys Gly Gln 
        35                  40                  45              


Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His Tyr Ala 
    50                  55                  60                  


Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His Tyr Tyr 
65                  70                  75                  80  


Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp His Phe 
                85                  90                  95      


Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu Tyr Phe 
            100                 105                 110         


Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr Leu His 
        115                 120                 125             


Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln Val Gly 
    130                 135                 140                 


Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu Arg Glu 
145                 150                 155                 160 


Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu Asn Ala 
                165                 170                 175     


Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly Tyr Leu 
            180                 185                 190         


Val Lys His Ala Thr Glu Pro 
        195                 


<210>  68
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Leu His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp 
        355                 360                 365             


Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg 
    370                 375                 380                 


Val Ile Glu Ala Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala 
385                 390                 395                 400 


Ala Glu Pro Val Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu 
                405                 410                 415     


Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu 
            420                 425                 430         


Val Gln Met Arg Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser 
        435                 440                 445             


Tyr Arg Pro Ala Glu Val Ala Glu Thr Gly Ala 
    450                 455                 


<210>  69
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Ser Arg Ala Gly 
                325                 330                 335     


Glu Glu Gly Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val 
            340                 345                 350         


Val Ala Val Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly 
        355                 360                 365             


Arg Tyr Phe Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys 
    370                 375                 380                 


Gly Ala Asp Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu 
385                 390                 395                 400 


Gly Gly Gln Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
                405                 410                 


<210>  70
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     


Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         


Thr Ile Leu Thr Ile Ile Thr Asp Thr Thr Ala Thr Thr Glu Pro Ala 
        355                 360                 365             


Val His Gly Leu Thr Gln Leu Pro Asn Ser Ala Glu Glu Leu Asp Ser 
    370                 375                 380                 


Glu Asp Leu Ser Asp Ser Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala 
385                 390                 395                 400 


Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val Val Phe Ala 
                405                 410                 415     


Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala Arg His Lys 
            420                 425                 430         


Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp Ala Ala Asp 
        435                 440                 445             


Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn Asn Ser Glu 
    450                 455                 460                 


Glu Lys Lys Glu Tyr Phe Ile 
465                 470     


<210>  71
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     


Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         


Thr Ile Leu Thr Ile Ile Thr Asp Thr Thr Ala Thr Thr Glu Pro Ala 
        355                 360                 365             


Val His Asp Ser Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp 
    370                 375                 380                 


His Ala Val Ile Gly Gly Val Val Ala Val Val Val Phe Ala Met Leu 
385                 390                 395                 400 


Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala Arg His Lys Gly Thr 
                405                 410                 415     


Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp Ala Ala Asp Ala Asp 
            420                 425                 430         


Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn Asn Ser Glu Glu Lys 
        435                 440                 445             


Lys Glu Tyr Phe Ile 
    450             


<210>  72
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Thr Thr Ala Thr 
                325                 330                 335     


Thr Glu Pro Ala Val His Gly Leu Thr Gln Leu Pro Asn Ser Ala Glu 
            340                 345                 350         


Glu Leu Asp Ser Glu Asp Leu Ser Asp Ser Arg Ala Gly Glu Glu Gly 
        355                 360                 365             


Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val 
    370                 375                 380                 


Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe 
385                 390                 395                 400 


Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp 
                405                 410                 415     


Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln 
            420                 425                 430         


Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
        435                 440             


<210>  73
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     


Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         


Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser 
        355                 360                 365             


Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val 
    370                 375                 380                 


Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala 
385                 390                 395                 400 


Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp 
                405                 410                 415     


Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn 
            420                 425                 430         


Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
        435                 440         


<210>  74
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Gly Ala Pro Ala Ala Ser Leu Leu Leu Leu Leu Leu Leu Phe Ala 
1               5                   10                  15      


Cys Cys Trp Ala Pro Gly Gly Ala Asn Leu Ser Gln Asp Asp Ser Gln 
            20                  25                  30          


Pro Trp Thr Ser Asp Glu Thr Val Val Ala Gly Gly Thr Val Val Leu 
        35                  40                  45              


Lys Cys Gln Val Lys Asp His Glu Asp Ser Ser Leu Gln Trp Ser Asn 
    50                  55                  60                  


Pro Ala Gln Gln Thr Leu Tyr Phe Gly Glu Lys Arg Ala Leu Arg Asp 
65                  70                  75                  80  


Asn Arg Ile Gln Leu Val Thr Ser Thr Pro His Glu Leu Ser Ile Ser 
                85                  90                  95      


Ile Ser Asn Val Ala Leu Ala Asp Glu Gly Glu Tyr Thr Cys Ser Ile 
            100                 105                 110         


Phe Thr Met Pro Val Arg Thr Ala Lys Ser Leu Val Thr Val Leu Gly 
        115                 120                 125             


Ile Pro Gln Lys Pro Ile Ile Thr Gly Tyr Lys Ser Ser Leu Arg Glu 
    130                 135                 140                 


Lys Asp Thr Ala Thr Leu Asn Cys Gln Ser Ser Gly Ser Lys Pro Ala 
145                 150                 155                 160 


Ala Arg Leu Thr Trp Arg Lys Gly Asp Gln Glu Leu His Gly Glu Pro 
                165                 170                 175     


Thr Arg Ile Gln Glu Asp Pro Asn Gly Lys Thr Phe Thr Val Ser Ser 
            180                 185                 190         


Ser Val Thr Phe Gln Val Thr Arg Glu Asp Asp Gly Ala Ser Ile Val 
        195                 200                 205             


Cys Ser Val Asn His Glu Ser Leu Lys Gly Ala Asp Arg Ser Thr Ser 
    210                 215                 220                 


Gln Arg Ile Glu Val Leu Tyr Thr Pro Thr Ala Met Ile Arg Pro Asp 
225                 230                 235                 240 


Pro Pro His Pro Arg Glu Gly Gln Lys Leu Leu Leu His Cys Glu Gly 
                245                 250                 255     


Arg Gly Asn Pro Val Pro Gln Gln Tyr Leu Trp Glu Lys Glu Gly Ser 
            260                 265                 270         


Val Pro Pro Leu Lys Met Thr Gln Glu Ser Ala Leu Ile Phe Pro Phe 
        275                 280                 285             


Leu Asn Lys Ser Asp Ser Gly Thr Tyr Gly Cys Thr Ala Thr Ser Asn 
    290                 295                 300                 


Met Gly Ser Tyr Lys Ala Tyr Tyr Thr Leu Asn Val Asn Asp Pro Ser 
305                 310                 315                 320 


Pro Val Pro Ser Ser Ser Ser Thr Tyr His Ala Ile Ile Gly Gly Ile 
                325                 330                 335     


Val Ala Phe Ile Val Phe Leu Leu Leu Ile Met Leu Ile Phe Leu Gly 
            340                 345                 350         


His Tyr Leu Ile Arg His Lys Gly Thr Tyr Leu Thr His Glu Ala Lys 
        355                 360                 365             


Gly Ser Asp Asp Ala Pro Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu 
    370                 375                 380                 


Gly Gly Gln Ser Gly Gly Asp Asp Lys Lys Glu Tyr Phe Ile 
385                 390                 395             


<210>  75
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Gly Ala Pro Ala Ala Ser Leu Leu Leu Leu Leu Leu Leu Phe Ala 
1               5                   10                  15      


Cys Cys Trp Ala Pro Gly Gly Ala Asn Leu Ser Gln Asp Asp Ser Gln 
            20                  25                  30          


Pro Trp Thr Ser Asp Glu Thr Val Val Ala Gly Gly Thr Val Val Leu 
        35                  40                  45              


Lys Cys Gln Val Lys Asp His Glu Asp Ser Ser Leu Gln Trp Ser Asn 
    50                  55                  60                  


Pro Ala Gln Gln Thr Leu Tyr Phe Gly Glu Lys Arg Ala Leu Arg Asp 
65                  70                  75                  80  


Asn Arg Ile Gln Leu Val Thr Ser Thr Pro His Glu Leu Ser Ile Ser 
                85                  90                  95      


Ile Ser Asn Val Ala Leu Ala Asp Glu Gly Glu Tyr Thr Cys Ser Ile 
            100                 105                 110         


Phe Thr Met Pro Val Arg Thr Ala Lys Ser Leu Val Thr Val Leu Gly 
        115                 120                 125             


Ile Pro Gln Lys Pro Ile Ile Thr Gly Tyr Lys Ser Ser Leu Arg Glu 
    130                 135                 140                 


Lys Asp Thr Ala Thr Leu Asn Cys Gln Ser Ser Gly Ser Lys Pro Ala 
145                 150                 155                 160 


Ala Arg Leu Thr Trp Arg Lys Gly Asp Gln Glu Leu His Gly Glu Pro 
                165                 170                 175     


Thr Arg Ile Gln Glu Asp Pro Asn Asp Thr Pro Thr Ala Met Ile Arg 
            180                 185                 190         


Pro Asp Pro Pro His Pro Arg Glu Gly Gln Lys Leu Leu Leu His Cys 
        195                 200                 205             


Glu Gly Arg Gly Asn Pro Val Pro Gln Gln Tyr Leu Trp Glu Lys Glu 
    210                 215                 220                 


Gly Ser Val Pro Pro Leu Lys Met Thr Gln Glu Ser Ala Leu Ile Phe 
225                 230                 235                 240 


Pro Phe Leu Asn Lys Ser Asp Ser Gly Thr Tyr Gly Cys Thr Ala Thr 
                245                 250                 255     


Ser Asn Met Gly Ser Tyr Lys Ala Tyr Tyr Thr Leu Asn Val Asn Asp 
            260                 265                 270         


Pro Ser Pro Val Pro Ser Ser Ser Ser Thr Tyr His Ala Ile Ile Gly 
        275                 280                 285             


Gly Ile Val Ala Phe Ile Val Phe Leu Leu Leu Ile Met Leu Ile Phe 
    290                 295                 300                 


Leu Gly His Tyr Leu Ile Arg His Lys Gly Thr Tyr Leu Thr His Glu 
305                 310                 315                 320 


Ala Lys Gly Ser Asp Asp Ala Pro Asp Ala Asp Thr Ala Ile Ile Asn 
                325                 330                 335     


Ala Glu Gly Gly Gln Ser Gly Gly Asp Asp Lys Lys Glu Tyr Phe Ile 
            340                 345                 350         


<210>  76
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Gly Ala Pro Ala Ala Ser Leu Leu Leu Leu Leu Leu Leu Phe Ala 
1               5                   10                  15      


Cys Cys Trp Ala Pro Gly Gly Ala Asn Leu Ser Gln Asp Gly Tyr Trp 
            20                  25                  30          


Gln Glu Gln Asp Leu Glu Leu Gly Thr Leu Ala Pro Leu Asp Glu Ala 
        35                  40                  45              


Ile Ser Ser Thr Val Trp Ser Ser Pro Asp Met Leu Ala Ser Gln Asp 
    50                  55                  60                  


Ser Gln Pro Trp Thr Ser Asp Glu Thr Val Val Ala Gly Gly Thr Val 
65                  70                  75                  80  


Val Leu Lys Cys Gln Val Lys Asp His Glu Asp Ser Ser Leu Gln Trp 
                85                  90                  95      


Ser Asn Pro Ala Gln Gln Thr Leu Tyr Phe Gly Glu Lys Arg Ala Leu 
            100                 105                 110         


Arg Asp Asn Arg Ile Gln Leu Val Thr Ser Thr Pro His Glu Leu Ser 
        115                 120                 125             


Ile Ser Ile Ser Asn Val Ala Leu Ala Asp Glu Gly Glu Tyr Thr Cys 
    130                 135                 140                 


Ser Ile Phe Thr Met Pro Val Arg Thr Ala Lys Ser Leu Val Thr Val 
145                 150                 155                 160 


Leu Gly Ile Pro Gln Lys Pro Ile Ile Thr Gly Tyr Lys Ser Ser Leu 
                165                 170                 175     


Arg Glu Lys Asp Thr Ala Thr Leu Asn Cys Gln Ser Ser Gly Ser Lys 
            180                 185                 190         


Pro Ala Ala Arg Leu Thr Trp Arg Lys Gly Asp Gln Glu Leu His Gly 
        195                 200                 205             


Glu Pro Thr Arg Ile Gln Glu Asp Pro Asn Gly Lys Thr Phe Thr Val 
    210                 215                 220                 


Ser Ser Ser Val Thr Phe Gln Val Thr Arg Glu Asp Asp Gly Ala Ser 
225                 230                 235                 240 


Ile Val Cys Ser Val Asn His Glu Ser Leu Lys Gly Ala Asp Arg Ser 
                245                 250                 255     


Thr Ser Gln Arg Ile Glu Val Leu Tyr Thr Pro Thr Ala Met Ile Arg 
            260                 265                 270         


Pro Asp Pro Pro His Pro Arg Glu Gly Gln Lys Leu Leu Leu His Cys 
        275                 280                 285             


Glu Gly Arg Gly Asn Pro Val Pro Gln Gln Tyr Leu Trp Glu Lys Glu 
    290                 295                 300                 


Gly Ser Val Pro Pro Leu Lys Met Thr Gln Glu Ser Ala Leu Ile Phe 
305                 310                 315                 320 


Pro Phe Leu Asn Lys Ser Asp Ser Gly Thr Tyr Gly Cys Thr Ala Thr 
                325                 330                 335     


Ser Asn Met Gly Ser Tyr Lys Ala Tyr Tyr Thr Leu Asn Val Asn Asp 
            340                 345                 350         


Pro Ser Pro Val Pro Ser Ser Ser Ser Thr Tyr His Ala Ile Ile Gly 
        355                 360                 365             


Gly Ile Val Ala Phe Ile Val Phe Leu Leu Leu Ile Met Leu Ile Phe 
    370                 375                 380                 


Leu Gly His Tyr Leu Ile Arg His Lys Gly Thr Tyr Leu Thr His Glu 
385                 390                 395                 400 


Ala Lys Gly Ser Asp Asp Ala Pro Asp Ala Asp Thr Ala Ile Ile Asn 
                405                 410                 415     


Ala Glu Gly Gly Gln Ser Gly Gly Asp Asp Lys Lys Glu Tyr Phe Ile 
            420                 425                 430         


<210>  77
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  78
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  79
<211>  1021
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ala Gly Ile Ser Tyr Val Ala Ser Phe Phe Leu Leu Leu Thr Lys 
1               5                   10                  15      


Leu Ser Ile Gly Gln Arg Glu Val Thr Val Gln Lys Gly Pro Leu Phe 
            20                  25                  30          


Arg Ala Glu Gly Tyr Pro Val Ser Ile Gly Cys Asn Val Thr Gly His 
        35                  40                  45              


Gln Gly Pro Ser Glu Gln His Phe Gln Trp Ser Val Tyr Leu Pro Thr 
    50                  55                  60                  


Asn Pro Thr Gln Glu Val Gln Ile Ile Ser Thr Lys Asp Ala Ala Phe 
65                  70                  75                  80  


Ser Tyr Ala Val Tyr Thr Gln Arg Val Arg Ser Gly Asp Val Tyr Val 
                85                  90                  95      


Glu Arg Val Gln Gly Asn Ser Val Leu Leu His Ile Ser Lys Leu Gln 
            100                 105                 110         


Met Lys Asp Ala Gly Glu Tyr Glu Cys His Thr Pro Asn Thr Asp Glu 
        115                 120                 125             


Lys Tyr Tyr Gly Ser Tyr Ser Ala Lys Thr Asn Leu Ile Val Ile Pro 
    130                 135                 140                 


Asp Thr Leu Ser Ala Thr Met Ser Ser Gln Thr Leu Gly Lys Glu Glu 
145                 150                 155                 160 


Gly Glu Pro Leu Ala Leu Thr Cys Glu Ala Ser Lys Ala Thr Ala Gln 
                165                 170                 175     


His Thr His Leu Ser Val Thr Trp Tyr Leu Thr Gln Asp Gly Gly Gly 
            180                 185                 190         


Ser Gln Ala Thr Glu Ile Ile Ser Leu Ser Lys Asp Phe Ile Leu Val 
        195                 200                 205             


Pro Gly Pro Leu Tyr Thr Glu Arg Phe Ala Ala Ser Asp Val Gln Leu 
    210                 215                 220                 


Asn Lys Leu Gly Pro Thr Thr Phe Arg Leu Ser Ile Glu Arg Leu Gln 
225                 230                 235                 240 


Ser Ser Asp Gln Gly Gln Leu Phe Cys Glu Ala Thr Glu Trp Ile Gln 
                245                 250                 255     


Asp Pro Asp Glu Thr Trp Met Phe Ile Thr Lys Lys Gln Thr Asp Gln 
            260                 265                 270         


Thr Thr Leu Arg Ile Gln Pro Ala Val Lys Asp Phe Gln Val Asn Ile 
        275                 280                 285             


Thr Ala Asp Ser Leu Phe Ala Glu Gly Lys Pro Leu Glu Leu Val Cys 
    290                 295                 300                 


Leu Val Val Ser Ser Gly Arg Asp Pro Gln Leu Gln Gly Ile Trp Phe 
305                 310                 315                 320 


Phe Asn Gly Thr Glu Ile Ala His Ile Asp Ala Gly Gly Val Leu Gly 
                325                 330                 335     


Leu Lys Asn Asp Tyr Lys Glu Arg Ala Ser Gln Gly Glu Leu Gln Val 
            340                 345                 350         


Ser Lys Leu Gly Pro Lys Ala Phe Ser Leu Lys Ile Phe Ser Leu Gly 
        355                 360                 365             


Pro Glu Asp Glu Gly Ala Tyr Arg Cys Val Val Ala Glu Val Met Lys 
    370                 375                 380                 


Thr Arg Thr Gly Ser Trp Gln Val Leu Gln Arg Lys Gln Ser Pro Asp 
385                 390                 395                 400 


Ser His Val His Leu Arg Lys Pro Ala Ala Arg Ser Val Val Met Ser 
                405                 410                 415     


Thr Lys Asn Lys Gln Gln Val Val Trp Glu Gly Glu Thr Leu Ala Phe 
            420                 425                 430         


Leu Cys Lys Ala Gly Gly Ala Glu Ser Pro Leu Ser Val Ser Trp Trp 
        435                 440                 445             


His Ile Pro Arg Asp Gln Thr Gln Pro Glu Phe Val Ala Gly Met Gly 
    450                 455                 460                 


Gln Asp Gly Ile Val Gln Leu Gly Ala Ser Tyr Gly Val Pro Ser Tyr 
465                 470                 475                 480 


His Gly Asn Thr Arg Leu Glu Lys Met Asp Trp Ala Thr Phe Gln Leu 
                485                 490                 495     


Glu Ile Thr Phe Thr Ala Ile Thr Asp Ser Gly Thr Tyr Glu Cys Arg 
            500                 505                 510         


Val Ser Glu Lys Ser Arg Asn Gln Ala Arg Asp Leu Ser Trp Thr Gln 
        515                 520                 525             


Lys Ile Ser Val Thr Val Lys Ser Leu Glu Ser Ser Leu Gln Val Ser 
    530                 535                 540                 


Leu Met Ser Arg Gln Pro Gln Val Met Leu Thr Asn Thr Phe Asp Leu 
545                 550                 555                 560 


Ser Cys Val Val Arg Ala Gly Tyr Ser Asp Leu Lys Val Pro Leu Thr 
                565                 570                 575     


Val Thr Trp Gln Phe Gln Pro Ala Ser Ser His Ile Phe His Gln Leu 
            580                 585                 590         


Ile Arg Ile Thr His Asn Gly Thr Ile Glu Trp Gly Asn Phe Leu Ser 
        595                 600                 605             


Arg Phe Gln Lys Lys Thr Lys Val Ser Gln Ser Leu Phe Arg Ser Gln 
    610                 615                 620                 


Leu Leu Val His Asp Ala Thr Glu Glu Glu Thr Gly Val Tyr Gln Cys 
625                 630                 635                 640 


Glu Val Glu Val Tyr Asp Arg Asn Ser Leu Tyr Asn Asn Arg Pro Pro 
                645                 650                 655     


Arg Ala Ser Ala Ile Ser His Pro Leu Arg Ile Ala Val Thr Leu Pro 
            660                 665                 670         


Glu Ser Lys Leu Lys Val Asn Ser Arg Ser Gln Val Gln Glu Leu Ser 
        675                 680                 685             


Ile Asn Ser Asn Thr Asp Ile Glu Cys Ser Ile Leu Ser Arg Ser Asn 
    690                 695                 700                 


Gly Asn Leu Gln Leu Ala Ile Ile Trp Tyr Phe Ser Pro Val Ser Thr 
705                 710                 715                 720 


Asn Ala Ser Trp Leu Lys Ile Leu Glu Met Asp Gln Thr Asn Val Ile 
                725                 730                 735     


Lys Thr Gly Asp Glu Phe His Thr Pro Gln Arg Lys Gln Lys Phe His 
            740                 745                 750         


Thr Glu Lys Val Ser Gln Asp Leu Phe Gln Leu His Ile Leu Asn Val 
        755                 760                 765             


Glu Asp Ser Asp Arg Gly Lys Tyr His Cys Ala Val Glu Glu Trp Leu 
    770                 775                 780                 


Leu Ser Thr Asn Gly Thr Trp His Lys Leu Gly Glu Lys Lys Ser Gly 
785                 790                 795                 800 


Leu Thr Glu Leu Lys Leu Lys Pro Thr Gly Ser Lys Val Arg Val Ser 
                805                 810                 815     


Lys Val Tyr Trp Thr Glu Asn Val Thr Glu His Arg Glu Val Ala Ile 
            820                 825                 830         


Arg Cys Ser Leu Glu Ser Val Gly Ser Ser Ala Thr Leu Tyr Ser Val 
        835                 840                 845             


Met Trp Tyr Trp Asn Arg Glu Asn Ser Gly Ser Lys Leu Leu Val His 
    850                 855                 860                 


Leu Gln His Asp Gly Leu Leu Glu Tyr Gly Glu Glu Gly Leu Arg Arg 
865                 870                 875                 880 


His Leu His Cys Tyr Arg Ser Ser Ser Thr Asp Phe Val Leu Lys Leu 
                885                 890                 895     


His Gln Val Glu Met Glu Asp Ala Gly Met Tyr Trp Cys Arg Val Ala 
            900                 905                 910         


Glu Trp Gln Leu His Gly His Pro Ser Lys Trp Ile Asn Gln Ala Ser 
        915                 920                 925             


Asp Glu Ser Gln Arg Met Val Leu Thr Val Leu Pro Ser Glu Pro Thr 
    930                 935                 940                 


Leu Pro Ser Arg Ile Cys Ser Ser Ala Pro Leu Leu Tyr Phe Leu Phe 
945                 950                 955                 960 


Ile Cys Pro Phe Val Leu Leu Leu Leu Leu Leu Ile Ser Leu Leu Cys 
                965                 970                 975     


Leu Tyr Trp Lys Ala Arg Lys Leu Ser Thr Leu Arg Ser Asn Thr Arg 
            980                 985                 990         


Lys Glu Lys Ala Leu Trp Val Asp  Leu Lys Glu Ala Gly  Gly Val Thr 
        995                 1000                 1005             


Thr Asn  Arg Arg Glu Asp Glu  Glu Glu Asp Glu Gly  Asn 
    1010                 1015                 1020     


<210>  80
<211>  1021
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ala Gly Ile Ser Tyr Val Ala Ser Phe Phe Leu Leu Leu Thr Lys 
1               5                   10                  15      


Leu Ser Ile Gly Gln Arg Glu Val Thr Val Gln Lys Gly Pro Leu Phe 
            20                  25                  30          


Arg Ala Glu Gly Tyr Pro Val Ser Ile Gly Cys Asn Val Thr Gly His 
        35                  40                  45              


Gln Gly Pro Ser Glu Gln His Phe Gln Trp Ser Val Tyr Leu Pro Thr 
    50                  55                  60                  


Asn Pro Thr Gln Glu Val Gln Ile Ile Ser Thr Lys Asp Ala Ala Phe 
65                  70                  75                  80  


Ser Tyr Ala Val Tyr Thr Gln Arg Val Arg Ser Gly Asp Val Tyr Val 
                85                  90                  95      


Glu Arg Val Gln Gly Asn Ser Val Leu Leu His Ile Ser Lys Leu Gln 
            100                 105                 110         


Met Lys Asp Ala Gly Glu Tyr Glu Cys His Thr Pro Asn Thr Asp Glu 
        115                 120                 125             


Lys Tyr Tyr Gly Ser Tyr Ser Ala Lys Thr Asn Leu Ile Val Ile Pro 
    130                 135                 140                 


Asp Thr Leu Ser Ala Thr Met Ser Ser Gln Thr Leu Gly Lys Glu Glu 
145                 150                 155                 160 


Gly Glu Pro Leu Ala Leu Thr Cys Glu Ala Ser Lys Ala Thr Ala Gln 
                165                 170                 175     


His Thr His Leu Ser Val Thr Trp Tyr Leu Thr Gln Asp Gly Gly Gly 
            180                 185                 190         


Ser Gln Ala Thr Glu Ile Ile Ser Leu Ser Lys Asp Phe Ile Leu Val 
        195                 200                 205             


Pro Gly Pro Leu Tyr Thr Glu Arg Phe Ala Ala Ser Asp Val Gln Leu 
    210                 215                 220                 


Asn Lys Leu Gly Pro Thr Thr Phe Arg Leu Ser Ile Glu Arg Leu Gln 
225                 230                 235                 240 


Ser Ser Asp Gln Gly Gln Leu Phe Cys Glu Ala Thr Glu Trp Ile Gln 
                245                 250                 255     


Asp Pro Asp Glu Thr Trp Met Phe Ile Thr Lys Lys Gln Thr Asp Gln 
            260                 265                 270         


Thr Thr Leu Arg Ile Gln Pro Ala Val Lys Asp Phe Gln Val Asn Ile 
        275                 280                 285             


Thr Ala Asp Ser Leu Phe Ala Glu Gly Lys Pro Leu Glu Leu Val Cys 
    290                 295                 300                 


Leu Val Val Ser Ser Gly Arg Asp Pro Gln Leu Gln Gly Ile Trp Phe 
305                 310                 315                 320 


Phe Asn Gly Thr Glu Ile Ala His Ile Asp Ala Gly Gly Val Leu Gly 
                325                 330                 335     


Leu Lys Asn Asp Tyr Lys Glu Arg Ala Ser Gln Gly Glu Leu Gln Val 
            340                 345                 350         


Ser Lys Leu Gly Pro Lys Ala Phe Ser Leu Lys Ile Phe Ser Leu Gly 
        355                 360                 365             


Pro Glu Asp Glu Gly Ala Tyr Arg Cys Val Val Ala Glu Val Met Lys 
    370                 375                 380                 


Thr Arg Thr Gly Ser Trp Gln Val Leu Gln Arg Lys Gln Ser Pro Asp 
385                 390                 395                 400 


Ser His Val His Leu Arg Lys Pro Ala Ala Arg Ser Val Val Met Ser 
                405                 410                 415     


Thr Lys Asn Lys Gln Gln Val Val Trp Glu Gly Glu Thr Leu Ala Phe 
            420                 425                 430         


Leu Cys Lys Ala Gly Gly Ala Glu Ser Pro Leu Ser Val Ser Trp Trp 
        435                 440                 445             


His Ile Pro Arg Asp Gln Thr Gln Pro Glu Phe Val Ala Gly Met Gly 
    450                 455                 460                 


Gln Asp Gly Ile Val Gln Leu Gly Ala Ser Tyr Gly Val Pro Ser Tyr 
465                 470                 475                 480 


His Gly Asn Thr Arg Leu Glu Lys Met Asp Trp Ala Thr Phe Gln Leu 
                485                 490                 495     


Glu Ile Thr Phe Thr Ala Ile Thr Asp Ser Gly Thr Tyr Glu Cys Arg 
            500                 505                 510         


Val Ser Glu Lys Ser Arg Asn Gln Ala Arg Asp Leu Ser Trp Thr Gln 
        515                 520                 525             


Lys Ile Ser Val Thr Val Lys Ser Leu Glu Ser Ser Leu Gln Val Ser 
    530                 535                 540                 


Leu Met Ser Arg Gln Pro Gln Val Met Leu Thr Asn Thr Phe Asp Leu 
545                 550                 555                 560 


Ser Cys Val Val Arg Ala Gly Tyr Ser Asp Leu Lys Val Pro Leu Thr 
                565                 570                 575     


Val Thr Trp Gln Phe Gln Pro Ala Ser Ser His Ile Phe His Gln Leu 
            580                 585                 590         


Ile Arg Ile Thr His Asn Gly Thr Ile Glu Trp Gly Asn Phe Leu Ser 
        595                 600                 605             


Arg Phe Gln Lys Lys Thr Lys Val Ser Gln Ser Leu Phe Arg Ser Gln 
    610                 615                 620                 


Leu Leu Val His Asp Ala Thr Glu Glu Glu Thr Gly Val Tyr Gln Cys 
625                 630                 635                 640 


Glu Val Glu Val Tyr Asp Arg Asn Ser Leu Tyr Asn Asn Arg Pro Pro 
                645                 650                 655     


Arg Ala Ser Ala Ile Ser His Pro Leu Arg Ile Ala Val Thr Leu Pro 
            660                 665                 670         


Glu Ser Lys Leu Lys Val Asn Ser Arg Ser Gln Val Gln Glu Leu Ser 
        675                 680                 685             


Ile Asn Ser Asn Thr Asp Ile Glu Cys Ser Ile Leu Ser Arg Ser Asn 
    690                 695                 700                 


Gly Asn Leu Gln Leu Ala Ile Ile Trp Tyr Phe Ser Pro Val Ser Thr 
705                 710                 715                 720 


Asn Ala Ser Trp Leu Lys Ile Leu Glu Met Asp Gln Thr Asn Val Ile 
                725                 730                 735     


Lys Thr Gly Asp Glu Phe His Thr Pro Gln Arg Lys Gln Lys Phe His 
            740                 745                 750         


Thr Glu Lys Val Ser Gln Asp Leu Phe Gln Leu His Ile Leu Asn Val 
        755                 760                 765             


Glu Asp Ser Asp Arg Gly Lys Tyr His Cys Ala Val Glu Glu Trp Leu 
    770                 775                 780                 


Leu Ser Thr Asn Gly Thr Trp His Lys Leu Gly Glu Lys Lys Ser Gly 
785                 790                 795                 800 


Leu Thr Glu Leu Lys Leu Lys Pro Thr Gly Ser Lys Val Arg Val Ser 
                805                 810                 815     


Lys Val Tyr Trp Thr Glu Asn Val Thr Glu His Arg Glu Val Ala Ile 
            820                 825                 830         


Arg Cys Ser Leu Glu Ser Val Gly Ser Ser Ala Thr Leu Tyr Ser Val 
        835                 840                 845             


Met Trp Tyr Trp Asn Arg Glu Asn Ser Gly Ser Lys Leu Leu Val His 
    850                 855                 860                 


Leu Gln His Asp Gly Leu Leu Glu Tyr Gly Glu Glu Gly Leu Arg Arg 
865                 870                 875                 880 


His Leu His Cys Tyr Arg Ser Ser Ser Thr Asp Phe Val Leu Lys Leu 
                885                 890                 895     


His Gln Val Glu Met Glu Asp Ala Gly Met Tyr Trp Cys Arg Val Ala 
            900                 905                 910         


Glu Trp Gln Leu His Gly His Pro Ser Lys Trp Ile Asn Gln Ala Ser 
        915                 920                 925             


Asp Glu Ser Gln Arg Met Val Leu Thr Val Leu Pro Ser Glu Pro Thr 
    930                 935                 940                 


Leu Pro Ser Arg Ile Cys Ser Ser Ala Pro Leu Leu Tyr Phe Leu Phe 
945                 950                 955                 960 


Ile Cys Pro Phe Val Leu Leu Leu Leu Leu Leu Ile Ser Leu Leu Cys 
                965                 970                 975     


Leu Tyr Trp Lys Ala Arg Lys Leu Ser Thr Leu Arg Ser Asn Thr Arg 
            980                 985                 990         


Lys Glu Lys Ala Leu Trp Val Asp  Leu Lys Glu Ala Gly  Gly Val Thr 
        995                 1000                 1005             


Thr Asn  Arg Arg Glu Asp Glu  Glu Glu Asp Glu Gly  Asn 
    1010                 1015                 1020     


<210>  81
<211>  1021
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Gly Ile Ser Tyr Val Ala Ser Phe Phe Leu Leu Leu Thr Lys 
1               5                   10                  15      


Leu Ser Ile Gly Gln Arg Glu Val Thr Val Gln Lys Gly Pro Leu Phe 
            20                  25                  30          


Arg Ala Glu Gly Tyr Pro Val Ser Ile Gly Cys Asn Val Thr Gly His 
        35                  40                  45              


Gln Gly Pro Ser Glu Gln His Phe Gln Trp Ser Val Tyr Leu Pro Thr 
    50                  55                  60                  


Asn Pro Thr Gln Glu Val Gln Ile Ile Ser Thr Lys Asp Ala Ala Phe 
65                  70                  75                  80  


Ser Tyr Ala Val Tyr Thr Gln Arg Val Arg Ser Gly Asp Val Tyr Val 
                85                  90                  95      


Glu Arg Val Gln Gly Asn Ser Val Leu Leu His Ile Ser Lys Leu Gln 
            100                 105                 110         


Met Lys Asp Ala Gly Glu Tyr Glu Cys His Thr Pro Asn Thr Asp Glu 
        115                 120                 125             


Lys Tyr Tyr Gly Ser Tyr Ser Ala Lys Thr Asn Leu Ile Val Ile Pro 
    130                 135                 140                 


Asp Thr Leu Ser Ala Thr Met Ser Ser Gln Thr Leu Gly Lys Glu Glu 
145                 150                 155                 160 


Gly Glu Pro Leu Ala Leu Thr Cys Glu Ala Ser Lys Ala Thr Ala Gln 
                165                 170                 175     


His Thr His Leu Ser Val Thr Trp Tyr Leu Thr Gln Asp Gly Gly Gly 
            180                 185                 190         


Ser Gln Ala Thr Glu Ile Ile Ser Leu Ser Lys Asp Phe Ile Leu Val 
        195                 200                 205             


Pro Gly Pro Leu Tyr Thr Glu Arg Phe Ala Ala Ser Asp Val Gln Leu 
    210                 215                 220                 


Asn Lys Leu Gly Pro Thr Thr Phe Arg Leu Ser Ile Glu Arg Leu Gln 
225                 230                 235                 240 


Ser Ser Asp Gln Gly Gln Leu Phe Cys Glu Ala Thr Glu Trp Ile Gln 
                245                 250                 255     


Asp Pro Asp Glu Thr Trp Met Phe Ile Thr Lys Lys Gln Thr Asp Gln 
            260                 265                 270         


Thr Thr Leu Arg Ile Gln Pro Ala Val Lys Asp Phe Gln Val Asn Ile 
        275                 280                 285             


Thr Ala Asp Ser Leu Phe Ala Glu Gly Lys Pro Leu Glu Leu Val Cys 
    290                 295                 300                 


Leu Val Val Ser Ser Gly Arg Asp Pro Gln Leu Gln Gly Ile Trp Phe 
305                 310                 315                 320 


Phe Asn Gly Thr Glu Ile Ala His Ile Asp Ala Gly Gly Val Leu Gly 
                325                 330                 335     


Leu Lys Asn Asp Tyr Lys Glu Arg Ala Ser Gln Gly Glu Leu Gln Val 
            340                 345                 350         


Ser Lys Leu Gly Pro Lys Ala Phe Ser Leu Lys Ile Phe Ser Leu Gly 
        355                 360                 365             


Pro Glu Asp Glu Gly Ala Tyr Arg Cys Val Val Ala Glu Val Met Lys 
    370                 375                 380                 


Thr Arg Thr Gly Ser Trp Gln Val Leu Gln Arg Lys Gln Ser Pro Asp 
385                 390                 395                 400 


Ser His Val His Leu Arg Lys Pro Ala Ala Arg Ser Val Val Met Ser 
                405                 410                 415     


Thr Lys Asn Lys Gln Gln Val Val Trp Glu Gly Glu Thr Leu Ala Phe 
            420                 425                 430         


Leu Cys Lys Ala Gly Gly Ala Glu Ser Pro Leu Ser Val Ser Trp Trp 
        435                 440                 445             


His Ile Pro Arg Asp Gln Thr Gln Pro Glu Phe Val Ala Gly Met Gly 
    450                 455                 460                 


Gln Asp Gly Ile Val Gln Leu Gly Ala Ser Tyr Gly Val Pro Ser Tyr 
465                 470                 475                 480 


His Gly Asn Thr Arg Leu Glu Lys Met Asp Trp Ala Thr Phe Gln Leu 
                485                 490                 495     


Glu Ile Thr Phe Thr Ala Ile Thr Asp Ser Gly Thr Tyr Glu Cys Arg 
            500                 505                 510         


Val Ser Glu Lys Ser Arg Asn Gln Ala Arg Asp Leu Ser Trp Thr Gln 
        515                 520                 525             


Lys Ile Ser Val Thr Val Lys Ser Leu Glu Ser Ser Leu Gln Val Ser 
    530                 535                 540                 


Leu Met Ser Arg Gln Pro Gln Val Met Leu Thr Asn Thr Phe Asp Leu 
545                 550                 555                 560 


Ser Cys Val Val Arg Ala Gly Tyr Ser Asp Leu Lys Val Pro Leu Thr 
                565                 570                 575     


Val Thr Trp Gln Phe Gln Pro Ala Ser Ser His Ile Phe His Gln Leu 
            580                 585                 590         


Ile Arg Ile Thr His Asn Gly Thr Ile Glu Trp Gly Asn Phe Leu Ser 
        595                 600                 605             


Arg Phe Gln Lys Lys Thr Lys Val Ser Gln Ser Leu Phe Arg Ser Gln 
    610                 615                 620                 


Leu Leu Val His Asp Ala Thr Glu Glu Glu Thr Gly Val Tyr Gln Cys 
625                 630                 635                 640 


Glu Val Glu Val Tyr Asp Arg Asn Ser Leu Tyr Asn Asn Arg Pro Pro 
                645                 650                 655     


Arg Ala Ser Ala Ile Ser His Pro Leu Arg Ile Ala Val Thr Leu Pro 
            660                 665                 670         


Glu Ser Lys Leu Lys Val Asn Ser Arg Ser Gln Val Gln Glu Leu Ser 
        675                 680                 685             


Ile Asn Ser Asn Thr Asp Ile Glu Cys Ser Ile Leu Ser Arg Ser Asn 
    690                 695                 700                 


Gly Asn Leu Gln Leu Ala Ile Ile Trp Tyr Phe Ser Pro Val Ser Thr 
705                 710                 715                 720 


Asn Ala Ser Trp Leu Lys Ile Leu Glu Met Asp Gln Thr Asn Val Ile 
                725                 730                 735     


Lys Thr Gly Asp Glu Phe His Thr Pro Gln Arg Lys Gln Lys Phe His 
            740                 745                 750         


Thr Glu Lys Val Ser Gln Asp Leu Phe Gln Leu His Ile Leu Asn Val 
        755                 760                 765             


Glu Asp Ser Asp Arg Gly Lys Tyr His Cys Ala Val Glu Glu Trp Leu 
    770                 775                 780                 


Leu Ser Thr Asn Gly Thr Trp His Lys Leu Gly Glu Lys Lys Ser Gly 
785                 790                 795                 800 


Leu Thr Glu Leu Lys Leu Lys Pro Thr Gly Ser Lys Val Arg Val Ser 
                805                 810                 815     


Lys Val Tyr Trp Thr Glu Asn Val Thr Glu His Arg Glu Val Ala Ile 
            820                 825                 830         


Arg Cys Ser Leu Glu Ser Val Gly Ser Ser Ala Thr Leu Tyr Ser Val 
        835                 840                 845             


Met Trp Tyr Trp Asn Arg Glu Asn Ser Gly Ser Lys Leu Leu Val His 
    850                 855                 860                 


Leu Gln His Asp Gly Leu Leu Glu Tyr Gly Glu Glu Gly Leu Arg Arg 
865                 870                 875                 880 


His Leu His Cys Tyr Arg Ser Ser Ser Thr Asp Phe Val Leu Lys Leu 
                885                 890                 895     


His Gln Val Glu Met Glu Asp Ala Gly Met Tyr Trp Cys Arg Val Ala 
            900                 905                 910         


Glu Trp Gln Leu His Gly His Pro Ser Lys Trp Ile Asn Gln Ala Ser 
        915                 920                 925             


Asp Glu Ser Gln Arg Met Val Leu Thr Val Leu Pro Ser Glu Pro Thr 
    930                 935                 940                 


Leu Pro Ser Arg Ile Cys Ser Ser Ala Pro Leu Leu Tyr Phe Leu Phe 
945                 950                 955                 960 


Ile Cys Pro Phe Val Leu Leu Leu Leu Leu Leu Ile Ser Leu Leu Cys 
                965                 970                 975     


Leu Tyr Trp Lys Ala Arg Lys Leu Ser Thr Leu Arg Ser Asn Thr Arg 
            980                 985                 990         


Lys Glu Lys Ala Leu Trp Val Asp  Leu Lys Glu Ala Gly  Gly Val Thr 
        995                 1000                 1005             


Thr Asn  Arg Arg Glu Asp Glu  Glu Glu Asp Glu Gly  Asn 
    1010                 1015                 1020     


<210>  82
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
            20                  25                  30          


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
        35                  40                  45              


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
    50                  55                  60                  


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
65                  70                  75                  80  


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
                85                  90                  95      


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
            100                 105                 110         


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 
        115                 120                 125             


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 
    130                 135                 140                 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
145                 150                 155                 160 


Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
                165                 170                 175     


<210>  83
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  84
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu 
    130                 135                 140                 


Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg 
145                 150                 155                 160 


Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr 
                165                 170                 175     


Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro 
            180                 185                 190         


Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp 
        195                 200                 205             


Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser 
    210                 215                 220                 


Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
225                 230                 235         


<210>  85
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Val Arg 
305                 310 


<210>  86
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  87
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  88
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  89
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  90
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  91
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  92
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Ser Ile Tyr Ala Val Phe 
225                 230                 235                 240 


Glu Ser Asp Val Asn Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu 
                245                 250                 255     


Pro Ser Lys Ala Phe Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys 
            260                 265                 270         


Phe Cys Thr Glu Lys Ile Ile Ser Lys Asn Cys Thr Ser Tyr Gly Val 
        275                 280                 285             


Leu Asp Ile Ser Lys Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu 
    290                 295                 300                 


Pro His Phe Leu Tyr Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly 
305                 310                 315                 320 


Leu Asn Pro Asn Glu Glu Glu His Arg Thr Tyr Leu Asp Ile Glu Pro 
                325                 330                 335     


Ile Thr Gly Phe Thr Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu 
            340                 345                 350         


Leu Val Lys Pro Ser Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg 
        355                 360                 365             


Asn Tyr Ile Val Pro Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly 
    370                 375                 380                 


Asp Glu Lys Ala Asn Met Phe Arg Ser Gln Val Thr Gly Lys Ile Asn 
385                 390                 395                 400 


Leu Leu Gly Leu Ile Glu Met Ile Leu Leu Ser Val Gly Val Val Met 
                405                 410                 415     


Phe Val Ala Phe Met Ile Ser Tyr Cys Ala Cys Arg Ser Lys Thr Ile 
            420                 425                 430         


Lys 
    


<210>  93
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Tyr 
    130                 135                 140                 


Asn Asn Thr Ala Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn 
145                 150                 155                 160 


Ile Ser Lys Val Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu 
                165                 170                 175     


Ser Tyr Trp Glu Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala 
            180                 185                 190         


Ser Phe Pro Pro Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser 
        195                 200                 205             


Ser Asp Ile Cys Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn 
    210                 215                 220                 


Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe 
225                 230                 235                 240 


Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys 
                245                 250                 255     


Ile Ile Ser Lys Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys 
            260                 265                 270         


Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr 
        275                 280                 285             


Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu 
    290                 295                 300                 


Glu Glu His Arg Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr 
305                 310                 315                 320 


Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser 
                325                 330                 335     


Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro 
            340                 345                 350         


Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn 
        355                 360                 365             


Met Phe Arg Ser Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile 
    370                 375                 380                 


Glu Met Ile Leu Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met 
385                 390                 395                 400 


Ile Ser Tyr Cys Ala Cys Arg Ser Lys Thr Ile Lys 
                405                 410         


<210>  94
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Met Asn Ser Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr 
1               5                   10                  15      


Tyr Arg Val Arg Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu 
            20                  25                  30          


Asp Asn Thr Val Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro 
        35                  40                  45              


Ser Leu Ser Val Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu 
    50                  55                  60                  


Ala Val Ala Ala Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met 
65                  70                  75                  80  


Ile Leu Asn Ser Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val 
                85                  90                  95      


Arg Thr Leu Arg Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser 
            100                 105                 110         


Leu Val Pro Tyr Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr 
        115                 120                 125             


Asn Asn Thr Ala Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn 
    130                 135                 140                 


Ile Ser Lys Val Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu 
145                 150                 155                 160 


Ser Tyr Trp Glu Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala 
                165                 170                 175     


Ser Phe Pro Pro Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser 
            180                 185                 190         


Ser Asp Ile Cys Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn 
        195                 200                 205             


Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe 
    210                 215                 220                 


Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys 
225                 230                 235                 240 


Ile Ile Ser Lys Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys 
                245                 250                 255     


Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr 
            260                 265                 270         


Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu 
        275                 280                 285             


Glu Glu His Arg Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr 
    290                 295                 300                 


Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser 
305                 310                 315                 320 


Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro 
                325                 330                 335     


Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn 
            340                 345                 350         


Met Phe Arg Ser Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile 
        355                 360                 365             


Glu Met Ile Leu Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met 
    370                 375                 380                 


Ile Ser Tyr Cys Ala Cys Arg Ser Lys Thr Ile Lys 
385                 390                 395     


<210>  95
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  96
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Leu Phe Gly Phe Trp Asn Trp Gly Leu Lys 
145                 150                 155                 160 


Val Lys Cys Phe Leu Arg His Leu Ile Trp Thr Ala His Cys Phe Ile 
                165                 170                 175     


Pro Leu Thr Gln Leu Val Phe Met Gln Ala Leu Gln Ser Trp Arg Asn 
            180                 185                 190         


His His Cys Ser His Phe Thr Asp Glu Glu Asn Arg Gly Val Asn Arg 
        195                 200                 205             


<210>  97
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  98
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Arg Ile 
                245                 250                 255     


Phe Pro Glu Gly Ser Cys Leu Asn Thr Phe Thr Lys Asn Pro Tyr Ala 
            260                 265                 270         


Ala Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr 
        275                 280                 285             


Gln Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val 
    290                 295                 300                 


Leu Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln 
305                 310                 315                 320 


Phe Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro 
                325                 330                 335     


Gly Thr Ser Ser Tyr Glu Ile Val Ile 
            340                 345 


<210>  99
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Ala Ser 
                245                 250                 255     


Leu Gln Gly Arg Ala Ser Glu His Ser Leu Phe Arg Ser Ala Val Cys 
            260                 265                 270         


<210>  100
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Cys 
1               5                   10                  15      


Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser Val Asn 
            20                  25                  30          


Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu Glu Lys 
        35                  40                  45              


Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn Val Leu 
    50                  55                  60                  


Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr Cys Thr 
65                  70                  75                  80  


Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala Arg Gln 
                85                  90                  95      


Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr Gly Leu 
            100                 105                 110         


Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu Ser Ser 
        115                 120                 125             


Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Asp Ala Ala Ser Lys 
    130                 135                 140                 


Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln Pro Ala 
145                 150                 155                 160 


Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu Pro Ser 
                165                 170                 175     


Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe Ala Asp 
            180                 185                 190         


Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly Thr Ser 
        195                 200                 205             


Ser Tyr Glu Ile Val Ile 
    210                 


<210>  101
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Ser Cys 
                245                 250                 255     


Leu Asn Thr Phe Thr Lys Asn Pro Tyr Ala Ala Ser Lys Lys Thr Ile 
            260                 265                 270         


Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln Pro Ala Glu Ser Arg 
        275                 280                 285             


Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu Pro Ser Lys Glu Glu 
    290                 295                 300                 


Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe Ala Asp Lys Met Gly 
305                 310                 315                 320 


Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly Thr Ser Ser Tyr Glu 
                325                 330                 335     


Ile Val Ile 
            


<210>  102
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Asp Ala Ala 
                245                 250                 255     


Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln 
            260                 265                 270         


Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu 
        275                 280                 285             


Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe 
    290                 295                 300                 


Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly 
305                 310                 315                 320 


Thr Ser Ser Tyr Glu Ile Val Ile 
                325             


<210>  103
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
            20                  25                  30          


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
        35                  40                  45              


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
    50                  55                  60                  


Asn Ser Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn 
65                  70                  75                  80  


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
                85                  90                  95      


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
            100                 105                 110         


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
        115                 120                 125             


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
    130                 135                 140                 


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
145                 150                 155                 160 


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
                165                 170                 175     


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
            180                 185                 190         


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
        195                 200                 205             


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
    210                 215         


<210>  104
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His 
1               5                   10                  15      


Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His 
            20                  25                  30          


Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu 
        35                  40                  45              


Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn 
    50                  55                  60                  


Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly 
65                  70                  75                  80  


Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser 
                85                  90                  95      


Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr 
            100                 105                 110         


Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
        115                 120                 125             


Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg 
    130                 135                 140                 


Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro 
145                 150                 155                 160 


Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile 
                165                 170                 175     


Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys 
            180                 185                 190         


Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu 
        195                 200                 205             


Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg 
    210                 215                 220                 


Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys 
225                 230                 235                 240 


Asp Lys Ser Asp Thr Cys Phe 
                245         


<210>  105
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val 
                245                 250                 255     


Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn 
            260                 265                 270         


Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln 
        275                 280                 285             


Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala 
    290                 295                 300                 


Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp 
305                 310                 315                 320 


Thr Cys Phe 
            


<210>  106
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  107
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln 
225                 230                 235                 240 


Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala 
                245                 250                 255     


Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp 
            260                 265                 270         


Thr Cys Phe 
        275 


<210>  108
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
        35                  40                  45              


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
    50                  55                  60                  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
65                  70                  75                  80  


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
                85                  90                  95      


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
            100                 105                 110         


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
        115                 120                 125             


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 
    130                 135                 140                 


Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 
145                 150                 155                 160 


Ala Val Gln Arg Thr Leu Leu Glu Lys 
                165                 


<210>  109
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
        35                  40                  45              


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
    50                  55                  60                  


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
65                  70                  75                  80  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
                85                  90                  95      


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
            100                 105                 110         


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
        115                 120                 125             


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
    130                 135                 140                 


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Asp Gly 
145                 150                 155                 160 


<210>  110
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
        35                  40                  45              


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
    50                  55                  60                  


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
65                  70                  75                  80  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
                85                  90                  95      


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
            100                 105                 110         


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
        115                 120                 125             


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
    130                 135                 140                 


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Glu Gln 
145                 150                 155                 160 


Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro Ala 
                165                 170                 175     


Val Gln Arg Thr Leu Leu Glu Lys 
            180                 


<210>  111
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
        35                  40                  45              


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
    50                  55                  60                  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
65                  70                  75                  80  


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
                85                  90                  95      


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
            100                 105                 110         


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
        115                 120                 125             


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Glu Gln 
    130                 135                 140                 


Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro Ala 
145                 150                 155                 160 


Val Gln Arg Thr Leu Leu Glu Lys 
                165             


<210>  112
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
        35                  40                  45              


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
    50                  55                  60                  


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
65                  70                  75                  80  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
                85                  90                  95      


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
            100                 105                 110         


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
        115                 120                 125             


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
    130                 135                 140                 


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 
145                 150                 155                 160 


Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 
                165                 170                 175     


Ala Val Gln Arg Thr Leu Leu Glu Lys 
            180                 185 


<210>  113
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Gly Leu Asp Phe Glu 
    370                 375                 380                 


Ala Lys Gln Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro 
385                 390                 395                 400 


Phe Glu Val Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val 
                405                 410                 415     


Leu Asp Val Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val 
            420                 425                 430         


Glu Val Ser Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr 
        435                 440                 445             


Ala Gln Glu Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile 
    450                 455                 460                 


Trp Arg Asp Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala 
465                 470                 475                 480 


Ile Ser Thr Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys 
                485                 490                 495     


Asn Ser Thr Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro 
            500                 505                 510         


Val Ala Thr Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn 
        515                 520                 525             


Asp Asn Ala Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg 
    530                 535                 540                 


Asn Pro Lys Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro 
545                 550                 555                 560 


Asn Thr Ser Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn 
                565                 570                 575     


Trp Thr Ile Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys 
            580                 585                 590         


Pro Lys Met Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu 
        595                 600                 605             


Met Asp Asn Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val 
    610                 615                 620                 


Cys Asp Cys Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val 
625                 630                 635                 640 


Glu Ala Gly Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile 
                645                 650                 655     


Leu Ala Leu Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg 
            660                 665                 670         


Arg Ala Val Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg 
        675                 680                 685             


Asp Asn Val Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln 
    690                 695                 700                 


Asp Phe Asp Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu 
705                 710                 715                 720 


Val Thr Arg Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr 
                725                 730                 735     


Leu Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu 
            740                 745                 750         


Asn Leu Lys Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser 
        755                 760                 765             


Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu 
    770                 775                 780                 


Ser Ser Leu Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr 
785                 790                 795                 800 


Leu Asn Glu Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly 
                805                 810                 815     


Gly Gly Glu Asp Asp 
            820     


<210>  114
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp Thr Ala Asn Trp 
1               5                   10                  15      


Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr Arg Ala Glu Leu 
            20                  25                  30          


Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr Tyr Thr Ala Leu 
        35                  40                  45              


Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr Gly Thr Gly Thr 
    50                  55                  60                  


Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala Pro Ile Pro Glu 
65                  70                  75                  80  


Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys Pro Gln Val Ile 
                85                  90                  95      


Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser Pro Phe Thr Ala 
            100                 105                 110         


Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile Gln Tyr Asn Asp 
        115                 120                 125             


Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met Ala Leu Glu Val 
    130                 135                 140                 


Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn Gln Asn Lys Asp 
145                 150                 155                 160 


Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys Glu Gly Ala Ala 
                165                 170                 175     


Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly Leu Gln Ile Pro 
            180                 185                 190         


Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu Leu Ile Leu Ile 
        195                 200                 205             


Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val Val Lys Glu Pro 
    210                 215                 220                 


Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val Tyr Tyr Tyr Asp 
225                 230                 235                 240 


Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp Leu Ser Gln Leu 
                245                 250                 255     


His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg Asn Asp Val Ala 
            260                 265                 270         


Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg Pro Ala Asn Pro 
        275                 280                 285             


Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys Ala Ala Asp Thr 
    290                 295                 300                 


Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu 
305                 310                 315                 320 


Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu Asn Ser Ser Glu 
                325                 330                 335     


Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu Trp Gly Asn Arg 
            340                 345                 350         


Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Asp Asp 
        355                 360                 365     


<210>  115
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp 
1               5                   10                  15      


Asn Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp 
            20                  25                  30          


Cys Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala 
        35                  40                  45              


Gly Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala 
    50                  55                  60                  


Leu Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala 
65                  70                  75                  80  


Val Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn 
                85                  90                  95      


Val Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe 
            100                 105                 110         


Asp Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr 
        115                 120                 125             


Arg Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro 
    130                 135                 140                 


Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu 
145                 150                 155                 160 


Lys Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu 
                165                 170                 175     


Val Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser 
            180                 185                 190         


Leu Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn 
        195                 200                 205             


Glu Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly 
    210                 215                 220                 


Glu Asp Asp 
225         


<210>  116
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  117
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Thr Ile His Gln Phe Leu Leu Leu Phe Leu Phe Trp Val Cys Leu 
1               5                   10                  15      


Pro His Phe Cys Ser Pro Glu Ile Met Phe Arg Arg Thr Pro Val Pro 
            20                  25                  30          


Gln Gln Arg Ile Leu Ser Ser Arg Val Pro Arg Ser Asp Gly Lys Ile 
        35                  40                  45              


Leu His Arg Gln Lys Arg Gly Trp Met Trp Asn Gln Phe Phe Leu Leu 
    50                  55                  60                  


Glu Glu Tyr Thr Gly Ser Asp Tyr Gln Tyr Val Gly Lys Leu His Ser 
65                  70                  75                  80  


Asp Gln Asp Lys Gly Asp Gly Ser Leu Lys Tyr Ile Leu Ser Gly Asp 
                85                  90                  95      


Gly Ala Gly Thr Leu Phe Ile Ile Asp Glu Lys Thr Gly Asp Ile His 
            100                 105                 110         


Ala Thr Arg Arg Ile Asp Arg Glu Glu Lys Ala Phe Tyr Thr Leu Arg 
        115                 120                 125             


Ala Gln Ala Ile Asn Arg Arg Thr Leu Arg Pro Val Glu Pro Glu Ser 
    130                 135                 140                 


Glu Phe Val Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Thr Phe 
145                 150                 155                 160 


Pro Glu Glu Ile Tyr Thr Ala Ser Val Pro Glu Met Ser Val Val Gly 
                165                 170                 175     


Thr Ser Val Val Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Ser Tyr 
            180                 185                 190         


Gly Asn Ser Ala Arg Val Ile Tyr Ser Ile Leu Gln Gly Gln Pro Tyr 
        195                 200                 205             


Phe Ser Val Glu Pro Glu Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn 
    210                 215                 220                 


Met Asn Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys 
225                 230                 235                 240 


Asp Met Gly Gly Gln Met Gly Gly Leu Ser Gly Thr Thr Thr Val Asn 
                245                 250                 255     


Ile Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Asn 
            260                 265                 270         


Thr Ile His Leu Arg Val Leu Glu Ser Ser Pro Val Gly Thr Ala Ile 
        275                 280                 285             


Gly Ser Val Lys Ala Thr Asp Ala Asp Thr Gly Lys Asn Ala Glu Val 
    290                 295                 300                 


Glu Tyr Arg Ile Ile Asp Gly Asp Gly Thr Asp Met Phe Asp Ile Val 
305                 310                 315                 320 


Thr Glu Lys Asp Thr Gln Glu Gly Ile Ile Thr Val Lys Lys Pro Leu 
                325                 330                 335     


Asp Tyr Glu Ser Arg Arg Leu Tyr Thr Leu Lys Val Glu Ala Glu Asn 
            340                 345                 350         


Thr His Val Asp Pro Arg Phe Tyr Tyr Leu Gly Pro Phe Lys Asp Thr 
        355                 360                 365             


Thr Ile Val Lys Ile Ser Ile Glu Asp Val Asp Glu Pro Pro Val Phe 
    370                 375                 380                 


Ser Arg Ser Ser Tyr Leu Phe Glu Val His Glu Asp Ile Glu Val Gly 
385                 390                 395                 400 


Thr Ile Ile Gly Thr Val Met Ala Arg Asp Pro Asp Ser Ile Ser Ser 
                405                 410                 415     


Pro Ile Arg Phe Ser Leu Asp Arg His Thr Asp Leu Asp Arg Ile Phe 
            420                 425                 430         


Asn Ile His Ser Gly Asn Gly Ser Leu Tyr Thr Ser Lys Pro Leu Asp 
        435                 440                 445             


Arg Glu Leu Ser Gln Trp His Asn Leu Thr Val Ile Ala Ala Glu Ile 
    450                 455                 460                 


Asn Asn Pro Lys Glu Thr Thr Arg Val Ala Val Phe Val Arg Ile Leu 
465                 470                 475                 480 


Asp Val Asn Asp Asn Ala Pro Gln Phe Ala Val Phe Tyr Asp Thr Phe 
                485                 490                 495     


Val Cys Glu Asn Ala Arg Pro Gly Gln Leu Ile Gln Thr Ile Ser Ala 
            500                 505                 510         


Val Asp Lys Asp Asp Pro Leu Gly Gly Gln Lys Phe Phe Phe Ser Leu 
        515                 520                 525             


Ala Ala Val Asn Pro Asn Phe Thr Val Gln Asp Asn Glu Asp Asn Thr 
    530                 535                 540                 


Ala Arg Ile Leu Thr Arg Lys Asn Gly Phe Asn Arg His Glu Ile Ser 
545                 550                 555                 560 


Thr Tyr Leu Leu Pro Val Val Ile Ser Asp Asn Asp Tyr Pro Ile Gln 
                565                 570                 575     


Ser Ser Thr Gly Thr Leu Thr Ile Arg Val Cys Ala Cys Asp Ser Gln 
            580                 585                 590         


Gly Asn Met Gln Ser Cys Ser Ala Glu Ala Leu Leu Leu Pro Ala Gly 
        595                 600                 605             


Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu 
    610                 615                 620                 


Leu Val Ile Val Val Leu Phe Ala Ala Leu Lys Arg Gln Arg Lys Lys 
625                 630                 635                 640 


Glu Pro Leu Ile Leu Ser Lys Glu Asp Ile Arg Asp Asn Ile Val Ser 
                645                 650                 655     


Tyr Asn Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala Phe Asp Ile 
            660                 665                 670         


Gly Thr Leu Arg Asn Pro Ala Ala Ile Glu Glu Lys Lys Leu Arg Arg 
        675                 680                 685             


Asp Ile Ile Pro Glu Thr Leu Phe Ile Pro Arg Arg Thr Pro Thr Ala 
    690                 695                 700                 


Pro Asp Asn Thr Asp Val Arg Asp Phe Ile Asn Glu Arg Leu Lys Glu 
705                 710                 715                 720 


His Asp Leu Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Ala Thr Tyr 
                725                 730                 735     


Ala Tyr Glu Gly Asn Asp Ser Ile Ala Glu Ser Leu Ser Ser Leu Glu 
            740                 745                 750         


Ser Gly Thr Thr Glu Gly Asp Gln Asn Tyr Asp Tyr Leu Arg Glu Trp 
        755                 760                 765             


Gly Pro Arg Phe Asn Lys Leu Ala Glu Met Tyr Gly Gly Gly Glu Ser 
    770                 775                 780                 


Asp Lys Asp Ser 
785             


<210>  118
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  


Ile Asp Ser Gly Asp Gly Asn Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         


Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             


Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 


Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 


His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val Thr Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln Ser Val 
            260                 265                 270         


Tyr Gln Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly 
        275                 280                 285             


Arg Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Val Thr 
    290                 295                 300                 


Tyr Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile Thr Thr 
305                 310                 315                 320 


Asp Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Val Asp 
                325                 330                 335     


Phe Glu Thr Lys Arg Ala Tyr Ser Leu Lys Val Glu Ala Ala Asn Val 
            340                 345                 350         


His Ile Asp Pro Lys Phe Ile Ser Asn Gly Pro Phe Lys Asp Thr Val 
        355                 360                 365             


Thr Val Lys Ile Ser Val Glu Asp Ala Asp Glu Pro Pro Met Phe Leu 
    370                 375                 380                 


Ala Pro Ser Tyr Ile His Glu Val Gln Glu Asn Ala Ala Ala Gly Thr 
385                 390                 395                 400 


Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn Ser Pro 
                405                 410                 415     


Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe Phe Thr 
            420                 425                 430         


Ile Asn Pro Glu Asp Gly Phe Ile Lys Thr Thr Lys Pro Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Ala Trp Leu Asn Ile Thr Val Phe Ala Ala Glu Ile His 
    450                 455                 460                 


Asn Arg His Gln Glu Ala Lys Val Pro Val Ala Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Lys Phe Ala Ala Pro Tyr Glu Gly Phe Ile 
                485                 490                 495     


Cys Glu Ser Asp Gln Thr Lys Pro Leu Ser Asn Gln Pro Ile Val Thr 
            500                 505                 510         


Ile Ser Ala Asp Asp Lys Asp Asp Thr Ala Asn Gly Pro Arg Phe Ile 
        515                 520                 525             


Phe Ser Leu Pro Pro Glu Ile Ile His Asn Pro Asn Phe Thr Val Arg 
    530                 535                 540                 


Asp Asn Arg Asp Asn Thr Ala Gly Val Tyr Ala Arg Arg Gly Gly Phe 
545                 550                 555                 560 


Ser Arg Gln Lys Gln Asp Leu Tyr Leu Leu Pro Ile Val Ile Ser Asp 
                565                 570                 575     


Gly Gly Ile Pro Pro Met Ser Ser Thr Asn Thr Leu Thr Ile Lys Val 
            580                 585                 590         


Cys Gly Cys Asp Val Asn Gly Ala Leu Leu Ser Cys Asn Ala Glu Ala 
        595                 600                 605             


Tyr Ile Leu Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu 
    610                 615                 620                 


Ala Cys Ile Val Ile Leu Leu Gly Cys Pro Ser Leu Met Glu Pro Pro 
625                 630                 635                 640 


Ser Pro Arg Glu Asp Met Arg Leu Leu Tyr Leu Gly Phe Gln Leu Met 
                645                 650                 655     


Leu Phe Ser Tyr Val Lys Val Asn Arg Arg Phe Cys Leu Leu Gly Val 
            660                 665                 670         


Phe Ile Lys Leu Pro Phe Leu Tyr Val Val Ala Thr Glu Ser Pro Thr 
        675                 680                 685             


Thr Leu Thr Ser Leu 
    690             


<210>  119
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  


Ile Asp Ser Gly Asp Gly Asn Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         


Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             


Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 


Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 


His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val Thr Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln Ser Val 
            260                 265                 270         


Tyr Gln Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly 
        275                 280                 285             


Arg Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Val Thr 
    290                 295                 300                 


Tyr Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile Thr Thr 
305                 310                 315                 320 


Asp Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Val Asp 
                325                 330                 335     


Phe Glu Thr Lys Arg Ala Tyr Ser Leu Lys Val Glu Ala Ala Asn Val 
            340                 345                 350         


His Ile Asp Pro Lys Phe Ile Ser Asn Gly Pro Phe Lys Asp Thr Val 
        355                 360                 365             


Thr Val Lys Ile Ser Val Glu Asp Ala Asp Glu Pro Pro Met Phe Leu 
    370                 375                 380                 


Ala Pro Ser Tyr Ile His Glu Val Gln Glu Asn Ala Ala Ala Gly Thr 
385                 390                 395                 400 


Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn Ser Pro 
                405                 410                 415     


Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe Phe Thr 
            420                 425                 430         


Ile Asn Pro Glu Asp Gly Phe Ile Lys Thr Thr Lys Pro Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Ala Trp Leu Asn Ile Thr Val Phe Ala Ala Glu Ile His 
    450                 455                 460                 


Asn Arg His Gln Glu Ala Lys Val Pro Val Ala Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Lys Phe Ala Ala Pro Tyr Glu Gly Phe Ile 
                485                 490                 495     


Cys Glu Ser Asp Gln Thr Lys Pro Leu Ser Asn Gln Pro Ile Val Thr 
            500                 505                 510         


Ile Ser Ala Asp Asp Lys Asp Asp Thr Ala Asn Gly Pro Arg Phe Ile 
        515                 520                 525             


Phe Ser Leu Pro Pro Glu Ile Ile His Asn Pro Asn Phe Thr Val Arg 
    530                 535                 540                 


Asp Asn Arg Asp Asn Thr Ala Gly Val Tyr Ala Arg Arg Gly Gly Phe 
545                 550                 555                 560 


Ser Arg Gln Lys Gln Asp Leu Tyr Leu Leu Pro Ile Val Ile Ser Asp 
                565                 570                 575     


Gly Gly Ile Pro Pro Met Ser Ser Thr Asn Thr Leu Thr Ile Lys Val 
            580                 585                 590         


Cys Gly Cys Asp Val Asn Gly Ala Leu Leu Ser Cys Asn Ala Glu Ala 
        595                 600                 605             


Tyr Ile Leu Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu 
    610                 615                 620                 


Ala Cys Ile Val Ile Leu Leu Val Ile Val Val Leu Phe Val Thr Leu 
625                 630                 635                 640 


Arg Arg Gln Lys Lys Glu Pro Leu Ile Val Phe Glu Glu Glu Asp Val 
                645                 650                 655     


Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp 
            660                 665                 670         


Thr Glu Ala Phe Asp Ile Ala Thr Leu Gln Asn Pro Asp Gly Ile Asn 
        675                 680                 685             


Gly Phe Ile Pro Arg Lys Asp Ile Lys Pro Glu Tyr Gln Tyr Met Pro 
    690                 695                 700                 


Arg Pro Gly Leu Arg Pro Ala Pro Asn Ser Val Asp Val Asp Asp Phe 
705                 710                 715                 720 


Ile Asn Thr Arg Ile Gln Glu Ala Asp Asn Asp Pro Thr Ala Pro Pro 
                725                 730                 735     


Tyr Asp Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg Gly Ser Val Ala 
            740                 745                 750         


Gly Ser Leu Ser Ser Leu Glu Ser Ala Thr Thr Asp Ser Asp Leu Asp 
        755                 760                 765             


Tyr Asp Tyr Leu Gln Asn Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp 
    770                 775                 780                 


Leu Tyr Gly Ser Lys Asp Thr Phe Asp Asp Asp Ser 
785                 790                 795     


<210>  120
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Arg Thr Tyr Arg Tyr Phe Leu Leu Leu Phe Trp Val Gly Gln Pro 
1               5                   10                  15      


Tyr Pro Thr Leu Ser Thr Pro Leu Ser Lys Arg Thr Ser Gly Phe Pro 
            20                  25                  30          


Ala Lys Lys Arg Ala Leu Glu Leu Ser Gly Asn Ser Lys Asn Glu Leu 
        35                  40                  45              


Asn Arg Ser Lys Arg Ser Trp Met Trp Asn Gln Phe Phe Leu Leu Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Ser Asp Tyr Gln Tyr Val Gly Lys Leu His Ser Asp 
65                  70                  75                  80  


Gln Asp Arg Gly Asp Gly Ser Leu Lys Tyr Ile Leu Ser Gly Asp Gly 
                85                  90                  95      


Ala Gly Asp Leu Phe Ile Ile Asn Glu Asn Thr Gly Asp Ile Gln Ala 
            100                 105                 110         


Thr Lys Arg Leu Asp Arg Glu Glu Lys Pro Val Tyr Ile Leu Arg Ala 
        115                 120                 125             


Gln Ala Ile Asn Arg Arg Thr Gly Arg Pro Val Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Ile Phe Thr 
145                 150                 155                 160 


Lys Glu Val Tyr Thr Ala Thr Val Pro Glu Met Ser Asp Val Gly Thr 
                165                 170                 175     


Phe Val Val Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ser Glu Thr Gly Ile Ile Lys Thr Ala Leu Leu Asn Met 
    210                 215                 220                 


Asp Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly Gln Met Gly Gly Leu Ser Gly Thr Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Ser Thr 
            260                 265                 270         


Tyr Gln Phe Lys Thr Pro Glu Ser Ser Pro Pro Gly Thr Pro Ile Gly 
        275                 280                 285             


Arg Ile Lys Ala Ser Asp Ala Asp Val Gly Glu Asn Ala Glu Ile Glu 
    290                 295                 300                 


Tyr Ser Ile Thr Asp Gly Glu Gly Leu Asp Met Phe Asp Val Ile Thr 
305                 310                 315                 320 


Asp Gln Glu Thr Gln Glu Gly Ile Ile Thr Val Lys Lys Leu Leu Asp 
                325                 330                 335     


Phe Glu Lys Lys Lys Val Tyr Thr Leu Lys Val Glu Ala Ser Asn Pro 
            340                 345                 350         


Tyr Val Glu Pro Arg Phe Leu Tyr Leu Gly Pro Phe Lys Asp Ser Ala 
        355                 360                 365             


Thr Val Arg Ile Val Val Glu Asp Val Asp Glu Pro Pro Val Phe Ser 
    370                 375                 380                 


Lys Leu Ala Tyr Ile Leu Gln Ile Arg Glu Asp Ala Gln Ile Asn Thr 
385                 390                 395                 400 


Thr Ile Gly Ser Val Thr Ala Gln Asp Pro Asp Ala Ala Arg Asn Pro 
                405                 410                 415     


Val Lys Tyr Ser Val Asp Arg His Thr Asp Met Asp Arg Ile Phe Asn 
            420                 425                 430         


Ile Asp Ser Gly Asn Gly Ser Ile Phe Thr Ser Lys Leu Leu Asp Arg 
        435                 440                 445             


Glu Thr Leu Leu Trp His Asn Ile Thr Val Ile Ala Thr Glu Ile Asn 
    450                 455                 460                 


Asn Pro Lys Gln Ser Ser Arg Val Pro Leu Tyr Ile Lys Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Glu Phe Ala Glu Phe Tyr Glu Thr Phe Val 
                485                 490                 495     


Cys Glu Lys Ala Lys Ala Asp Gln Leu Ile Gln Thr Leu His Ala Val 
            500                 505                 510         


Asp Lys Asp Asp Pro Tyr Ser Gly His Gln Phe Ser Phe Ser Leu Ala 
        515                 520                 525             


Pro Glu Ala Ala Ser Gly Ser Asn Phe Thr Ile Gln Asp Asn Lys Asp 
    530                 535                 540                 


Asn Thr Ala Gly Ile Leu Thr Arg Lys Asn Gly Tyr Asn Arg His Glu 
545                 550                 555                 560 


Met Ser Thr Tyr Leu Leu Pro Val Val Ile Ser Asp Asn Asp Tyr Pro 
                565                 570                 575     


Val Gln Ser Ser Thr Gly Thr Val Thr Val Arg Val Cys Ala Cys Asp 
            580                 585                 590         


His His Gly Asn Met Gln Ser Cys His Ala Glu Ala Leu Ile His Pro 
        595                 600                 605             


Thr Gly Leu Ser Thr Gly Ala Leu Val Ala Ile Leu Leu Cys Ile Val 
    610                 615                 620                 


Ile Leu Leu Val Thr Val Val Leu Phe Ala Ala Leu Arg Arg Gln Arg 
625                 630                 635                 640 


Lys Lys Glu Pro Leu Ile Ile Ser Lys Glu Asp Ile Arg Asp Asn Ile 
                645                 650                 655     


Val Ser Tyr Asn Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala Phe 
            660                 665                 670         


Asp Ile Gly Thr Leu Arg Asn Pro Glu Ala Ile Glu Asp Asn Lys Leu 
        675                 680                 685             


Arg Arg Asp Ile Val Pro Glu Ala Leu Phe Leu Pro Arg Arg Thr Pro 
    690                 695                 700                 


Thr Ala Arg Asp Asn Thr Asp Val Arg Asp Phe Ile Asn Gln Arg Leu 
705                 710                 715                 720 


Lys Glu Asn Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Ala 
                725                 730                 735     


Thr Tyr Ala Tyr Glu Gly Thr Gly Ser Val Ala Asp Ser Leu Ser Ser 
            740                 745                 750         


Leu Glu Ser Val Thr Thr Asp Ala Asp Gln Asp Tyr Asp Tyr Leu Ser 
        755                 760                 765             


Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Val 
    770                 775                 780                 


Asp Ser Asp Lys Asp Ser 
785                 790 


<210>  121
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Lys Leu Gly Lys Val Glu Phe Cys His Phe Leu Gln Leu Ile Ala 
1               5                   10                  15      


Leu Phe Leu Cys Phe Ser Gly Met Ser Gln Ala Glu Leu Ser Arg Ser 
            20                  25                  30          


Arg Ser Lys Pro Tyr Phe Gln Ser Gly Arg Ser Arg Thr Lys Arg Ser 
        35                  40                  45              


Trp Val Trp Asn Gln Phe Phe Val Leu Glu Glu Tyr Met Gly Ser Asp 
    50                  55                  60                  


Pro Leu Tyr Val Gly Lys Leu His Ser Asp Val Asp Lys Gly Asp Gly 
65                  70                  75                  80  


Ser Ile Lys Tyr Ile Leu Ser Gly Glu Gly Ala Ser Ser Ile Phe Ile 
                85                  90                  95      


Ile Asp Glu Asn Thr Gly Asp Ile His Ala Thr Lys Arg Leu Asp Arg 
            100                 105                 110         


Glu Glu Gln Ala Tyr Tyr Thr Leu Arg Ala Gln Ala Leu Asp Arg Leu 
        115                 120                 125             


Thr Asn Lys Pro Val Glu Pro Glu Ser Glu Phe Val Ile Lys Ile Gln 
    130                 135                 140                 


Asp Ile Asn Asp Asn Glu Pro Lys Phe Leu Asp Gly Pro Tyr Thr Ala 
145                 150                 155                 160 


Gly Val Pro Glu Met Ser Pro Val Gly Thr Ser Val Val Gln Val Thr 
                165                 170                 175     


Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly Asn Ser Ala Arg Val Val 
            180                 185                 190         


Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe Ser Val Glu Pro Lys Thr 
        195                 200                 205             


Gly Val Ile Lys Thr Ala Leu Pro Asn Met Asp Arg Glu Ala Lys Asp 
    210                 215                 220                 


Gln Tyr Leu Leu Val Ile Gln Ala Lys Asp Met Val Gly Gln Asn Gly 
225                 230                 235                 240 


Gly Leu Ser Gly Thr Thr Ser Val Thr Val Thr Leu Thr Asp Val Asn 
                245                 250                 255     


Asp Asn Pro Pro Arg Phe Pro Arg Arg Ser Tyr Gln Tyr Asn Val Pro 
            260                 265                 270         


Glu Ser Leu Pro Val Ala Ser Val Val Ala Arg Ile Lys Ala Ala Asp 
        275                 280                 285             


Ala Asp Ile Gly Ala Asn Ala Glu Met Glu Tyr Lys Ile Val Asp Gly 
    290                 295                 300                 


Asp Gly Leu Gly Ile Phe Lys Ile Ser Val Asp Lys Glu Thr Gln Glu 
305                 310                 315                 320 


Gly Ile Ile Thr Ile Gln Lys Glu Leu Asp Phe Glu Ala Lys Thr Ser 
                325                 330                 335     


Tyr Thr Leu Arg Ile Glu Ala Ala Asn Lys Asp Ala Asp Pro Arg Phe 
            340                 345                 350         


Leu Ser Leu Gly Pro Phe Ser Asp Thr Thr Thr Val Lys Ile Ile Val 
        355                 360                 365             


Glu Asp Val Asp Glu Pro Pro Val Phe Ser Ser Pro Leu Tyr Pro Met 
    370                 375                 380                 


Glu Val Ser Glu Ala Thr Gln Val Gly Asn Ile Ile Gly Thr Val Ala 
385                 390                 395                 400 


Ala His Asp Pro Asp Ser Ser Asn Ser Pro Val Arg Tyr Ser Ile Asp 
                405                 410                 415     


Arg Asn Thr Asp Leu Glu Arg Tyr Phe Asn Ile Asp Ala Asn Ser Gly 
            420                 425                 430         


Val Ile Thr Thr Ala Lys Ser Leu Asp Arg Glu Thr Asn Ala Ile His 
        435                 440                 445             


Asn Ile Thr Val Leu Ala Met Glu Ser Gln Asn Pro Ser Gln Val Gly 
    450                 455                 460                 


Arg Gly Tyr Val Ala Ile Thr Ile Leu Asp Ile Asn Asp Asn Ala Pro 
465                 470                 475                 480 


Glu Phe Ala Met Asp Tyr Glu Thr Thr Val Cys Glu Asn Ala Gln Pro 
                485                 490                 495     


Gly Gln Val Ile Gln Lys Ile Ser Ala Val Asp Lys Asp Glu Pro Ser 
            500                 505                 510         


Asn Gly His Gln Phe Tyr Phe Ser Leu Thr Thr Asp Ala Thr Asn Asn 
        515                 520                 525             


His Asn Phe Ser Leu Lys Asp Asn Lys Asp Asn Thr Ala Ser Ile Leu 
    530                 535                 540                 


Thr Arg Arg Asn Gly Phe Arg Arg Gln Glu Gln Ser Val Tyr Tyr Leu 
545                 550                 555                 560 


Pro Ile Phe Ile Val Asp Ser Gly Ser Pro Ser Leu Ser Ser Thr Asn 
                565                 570                 575     


Thr Leu Thr Ile Arg Val Cys Asp Cys Asp Ala Asp Gly Val Ala Gln 
            580                 585                 590         


Thr Cys Asn Ala Glu Ala Tyr Val Leu Pro Ala Gly Leu Ser Thr Gly 
        595                 600                 605             


Ala Leu Ile Ala Ile Leu Ala Cys Val Leu Thr Leu Leu Gly Arg Tyr 
    610                 615                 620                 


Cys Phe Gln Gly Leu Leu 
625                 630 


<210>  122
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Lys Leu Gly Lys Val Glu Phe Cys His Phe Leu Gln Leu Ile Ala 
1               5                   10                  15      


Leu Phe Leu Cys Phe Ser Gly Met Ser Gln Ala Glu Leu Ser Arg Ser 
            20                  25                  30          


Arg Ser Lys Pro Tyr Phe Gln Ser Gly Arg Ser Arg Thr Lys Arg Ser 
        35                  40                  45              


Trp Val Trp Asn Gln Phe Phe Val Leu Glu Glu Tyr Met Gly Ser Asp 
    50                  55                  60                  


Pro Leu Tyr Val Gly Lys Leu His Ser Asp Val Asp Lys Gly Asp Gly 
65                  70                  75                  80  


Ser Ile Lys Tyr Ile Leu Ser Gly Glu Gly Ala Ser Ser Ile Phe Ile 
                85                  90                  95      


Ile Asp Glu Asn Thr Gly Asp Ile His Ala Thr Lys Arg Leu Asp Arg 
            100                 105                 110         


Glu Glu Gln Ala Tyr Tyr Thr Leu Arg Ala Gln Ala Leu Asp Arg Leu 
        115                 120                 125             


Thr Asn Lys Pro Val Glu Pro Glu Ser Glu Phe Val Ile Lys Ile Gln 
    130                 135                 140                 


Asp Ile Asn Asp Asn Glu Pro Lys Phe Leu Asp Gly Pro Tyr Thr Ala 
145                 150                 155                 160 


Gly Val Pro Glu Met Ser Pro Val Gly Thr Ser Val Val Gln Val Thr 
                165                 170                 175     


Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly Asn Ser Ala Arg Val Val 
            180                 185                 190         


Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe Ser Val Glu Pro Lys Thr 
        195                 200                 205             


Gly Val Ile Lys Thr Ala Leu Pro Asn Met Asp Arg Glu Ala Lys Asp 
    210                 215                 220                 


Gln Tyr Leu Leu Val Ile Gln Ala Lys Asp Met Val Gly Gln Asn Gly 
225                 230                 235                 240 


Gly Leu Ser Gly Thr Thr Ser Val Thr Val Thr Leu Thr Asp Val Asn 
                245                 250                 255     


Asp Asn Pro Pro Arg Phe Pro Arg Arg Ser Tyr Gln Tyr Asn Val Pro 
            260                 265                 270         


Glu Ser Leu Pro Val Ala Ser Val Val Ala Arg Ile Lys Ala Ala Asp 
        275                 280                 285             


Ala Asp Ile Gly Ala Asn Ala Glu Met Glu Tyr Lys Ile Val Asp Gly 
    290                 295                 300                 


Asp Gly Leu Gly Ile Phe Lys Ile Ser Val Asp Lys Glu Thr Gln Glu 
305                 310                 315                 320 


Gly Ile Ile Thr Ile Gln Lys Glu Leu Asp Phe Glu Ala Lys Thr Ser 
                325                 330                 335     


Tyr Thr Leu Arg Ile Glu Ala Ala Asn Lys Asp Ala Asp Pro Arg Phe 
            340                 345                 350         


Leu Ser Leu Gly Pro Phe Ser Asp Thr Thr Thr Val Lys Ile Ile Val 
        355                 360                 365             


Glu Asp Val Asp Glu Pro Pro Val Phe Ser Ser Pro Leu Tyr Pro Met 
    370                 375                 380                 


Glu Val Ser Glu Ala Thr Gln Val Gly Asn Ile Ile Gly Thr Val Ala 
385                 390                 395                 400 


Ala His Asp Pro Asp Ser Ser Asn Ser Pro Val Arg Tyr Ser Ile Asp 
                405                 410                 415     


Arg Asn Thr Asp Leu Glu Arg Tyr Phe Asn Ile Asp Ala Asn Ser Gly 
            420                 425                 430         


Val Ile Thr Thr Ala Lys Ser Leu Asp Arg Glu Thr Asn Ala Ile His 
        435                 440                 445             


Asn Ile Thr Val Leu Ala Met Glu Ser Gln Asn Pro Ser Gln Val Gly 
    450                 455                 460                 


Arg Gly Tyr Val Ala Ile Thr Ile Leu Asp Ile Asn Asp Asn Ala Pro 
465                 470                 475                 480 


Glu Phe Ala Met Asp Tyr Glu Thr Thr Val Cys Glu Asn Ala Gln Pro 
                485                 490                 495     


Gly Gln Val Ile Gln Lys Ile Ser Ala Val Asp Lys Asp Glu Pro Ser 
            500                 505                 510         


Asn Gly His Gln Phe Tyr Phe Ser Leu Thr Thr Asp Ala Thr Asn Asn 
        515                 520                 525             


His Asn Phe Ser Leu Lys Asp Asn Lys Asp Asn Thr Ala Ser Ile Leu 
    530                 535                 540                 


Thr Arg Arg Asn Gly Phe Arg Arg Gln Glu Gln Ser Val Tyr Tyr Leu 
545                 550                 555                 560 


Pro Ile Phe Ile Val Asp Ser Gly Ser Pro Ser Leu Ser Ser Thr Asn 
                565                 570                 575     


Thr Leu Thr Ile Arg Val Cys Asp Cys Asp Ala Asp Gly Val Ala Gln 
            580                 585                 590         


Thr Cys Asn Ala Glu Ala Tyr Val Leu Pro Ala Gly Leu Ser Thr Gly 
        595                 600                 605             


Ala Leu Ile Ala Ile Leu Ala Cys Val Leu Thr Leu Leu Val Leu Ile 
    610                 615                 620                 


Leu Leu Ile Val Thr Met Arg Arg Arg Lys Lys Glu Pro Leu Ile Phe 
625                 630                 635                 640 


Asp Glu Glu Arg Asp Ile Arg Glu Asn Ile Val Arg Tyr Asp Asp Glu 
                645                 650                 655     


Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp Met Ala Ala Leu Arg 
            660                 665                 670         


Asn Leu Asn Val Ile Arg Asp Thr Lys Thr Arg Arg Asp Val Thr Pro 
        675                 680                 685             


Glu Ile Gln Phe Leu Ser Arg Pro Ala Phe Lys Ser Ile Pro Asp Asn 
    690                 695                 700                 


Val Ile Phe Arg Glu Phe Ile Trp Glu Arg Leu Lys Glu Ala Asp Val 
705                 710                 715                 720 


Asp Pro Gly Ala Pro Pro Tyr Asp Ser Leu Gln Thr Tyr Ala Phe Glu 
                725                 730                 735     


Gly Asn Gly Ser Val Ala Glu Ser Leu Ser Ser Leu Asp Ser Ile Ser 
            740                 745                 750         


Ser Asn Ser Asp Gln Asn Tyr Asp Tyr Leu Ser Asp Trp Gly Pro Arg 
        755                 760                 765             


Phe Lys Arg Leu Ala Asp Met Tyr Gly Thr Gly Gln Glu Ser Leu Tyr 
    770                 775                 780                 


Ser 
785 


<210>  123
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Lys Leu Gly Lys Val Glu Phe Cys His Phe Leu Gln Leu Ile Ala 
1               5                   10                  15      


Leu Phe Leu Cys Phe Ser Gly Met Ser Gln Ala Glu Leu Ser Arg Ser 
            20                  25                  30          


Arg Ser Lys Pro Tyr Phe Gln Ser Gly Arg Ser Arg Thr Lys Arg Ser 
        35                  40                  45              


Trp Val Trp Asn Gln Phe Phe Val Leu Glu Glu Tyr Met Gly Ser Asp 
    50                  55                  60                  


Pro Leu Tyr Val Gly Lys Leu His Ser Asp Val Asp Lys Gly Asp Gly 
65                  70                  75                  80  


Ser Ile Lys Tyr Ile Leu Ser Gly Glu Gly Ala Ser Ser Ile Phe Ile 
                85                  90                  95      


Ile Asp Glu Asn Thr Gly Asp Ile His Ala Thr Lys Arg Leu Asp Arg 
            100                 105                 110         


Glu Glu Gln Ala Tyr Tyr Thr Leu Arg Ala Gln Ala Leu Asp Arg Leu 
        115                 120                 125             


Thr Asn Lys Pro Val Glu Pro Glu Ser Glu Phe Val Ile Lys Ile Gln 
    130                 135                 140                 


Asp Ile Asn Asp Asn Glu Pro Lys Phe Leu Asp Gly Pro Tyr Thr Ala 
145                 150                 155                 160 


Gly Val Pro Glu Met Ser Pro Val Gly Thr Ser Val Val Gln Val Thr 
                165                 170                 175     


Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly Asn Ser Ala Arg Val Val 
            180                 185                 190         


Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe Ser Val Glu Pro Lys Thr 
        195                 200                 205             


Gly Val Ile Lys Thr Ala Leu Pro Asn Met Asp Arg Glu Ala Lys Asp 
    210                 215                 220                 


Gln Tyr Leu Leu Val Ile Gln Ala Lys Asp Met Val Gly Gln Asn Gly 
225                 230                 235                 240 


Gly Leu Ser Gly Thr Thr Ser Val Thr Val Thr Leu Thr Asp Val Asn 
                245                 250                 255     


Asp Asn Pro Pro Arg Phe Pro Arg Arg Ser Tyr Gln Tyr Asn Val Pro 
            260                 265                 270         


Glu Ser Leu Pro Val Ala Ser Val Val Ala Arg Ile Lys Ala Ala Asp 
        275                 280                 285             


Ala Asp Ile Gly Ala Asn Ala Glu Met Glu Tyr Lys Ile Val Asp Gly 
    290                 295                 300                 


Asp Gly Leu Gly Ile Phe Lys Ile Ser Val Asp Lys Glu Thr Gln Glu 
305                 310                 315                 320 


Gly Ile Ile Thr Ile Gln Lys Glu Leu Asp Phe Glu Ala Lys Thr Ser 
                325                 330                 335     


Tyr Thr Leu Arg Ile Glu Ala Ala Asn Lys Asp Ala Asp Pro Arg Phe 
            340                 345                 350         


Leu Ser Leu Gly Pro Phe Ser Asp Thr Thr Thr Val Lys Ile Ile Val 
        355                 360                 365             


Glu Asp Val Asp Glu Pro Pro Val Phe Ser Ser Pro Leu Tyr Pro Met 
    370                 375                 380                 


Glu Val Ser Glu Ala Thr Gln Val Gly Asn Ile Ile Gly Thr Val Ala 
385                 390                 395                 400 


Ala His Asp Pro Asp Ser Ser Asn Ser Pro Val Arg Tyr Ser Ile Asp 
                405                 410                 415     


Arg Asn Thr Asp Leu Glu Arg Tyr Phe Asn Ile Asp Ala Asn Ser Gly 
            420                 425                 430         


Val Ile Thr Thr Ala Lys Ser Leu Asp Arg Glu Thr Asn Ala Ile His 
        435                 440                 445             


Asn Ile Thr Val Leu Ala Met Glu Ser Gln Asn Pro Ser Gln Val Gly 
    450                 455                 460                 


Arg Gly Tyr Val Ala Ile Thr Ile Leu Asp Ile Asn Asp Asn Ala Pro 
465                 470                 475                 480 


Glu Phe Ala Met Asp Tyr Glu Thr Thr Val Cys Glu Asn Ala Gln Pro 
                485                 490                 495     


Gly Gln Val Ile Gln Lys Ile Ser Ala Val Asp Lys Asp Glu Pro Ser 
            500                 505                 510         


Asn Gly His Gln Phe Tyr Phe Ser Leu Thr Thr Asp Ala Thr Asn Asn 
        515                 520                 525             


His Asn Phe Ser Leu Lys Asp Asn Lys Asp Asn Thr Ala Ser Ile Leu 
    530                 535                 540                 


Thr Arg Arg Asn Gly Phe Arg Arg Gln Glu Gln Ser Val Tyr Tyr Leu 
545                 550                 555                 560 


Pro Ile Phe Ile Val Asp Ser Gly Ser Pro Ser Leu Ser Ser Thr Asn 
                565                 570                 575     


Thr Leu Thr Ile Arg Val Cys Asp Cys Asp Ala Asp Gly Val Ala Gln 
            580                 585                 590         


Thr Cys Asn Ala Glu Ala Tyr Val Leu Pro Ala Gly Leu Ser Thr Gly 
        595                 600                 605             


Ala Leu Ile Ala Ile Leu Ala Cys Val Leu Thr Leu Leu Val Leu Ile 
    610                 615                 620                 


Leu Leu Ile Val Thr Met Arg Arg Arg Lys Lys Glu Pro Leu Ile Phe 
625                 630                 635                 640 


Asp Glu Glu Arg Asp Ile Arg Glu Asn Ile Val Arg Tyr Asp Asp Glu 
                645                 650                 655     


Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp Met Ala Ala Leu Arg 
            660                 665                 670         


Asn Leu Asn Val Ile Arg Asp Thr Lys Thr Arg Arg Asp Val Thr Pro 
        675                 680                 685             


Glu Ile Gln Phe Leu Ser Arg Pro Ala Phe Lys Ser Ile Pro Asp Asn 
    690                 695                 700                 


Val Ile Phe Arg Glu Phe Ile Trp Glu Arg Leu Lys Glu Ala Asp Val 
705                 710                 715                 720 


Asp Pro Gly Ala Pro Pro Tyr Asp Ser Leu Gln Thr Tyr Ala Phe Glu 
                725                 730                 735     


Gly Asn Gly Ser Val Ala Glu Ser Leu Ser Ser Leu Asp Ser Ile Ser 
            740                 745                 750         


Ser Asn Ser Asp Gln Asn Tyr Asp Tyr Leu Ser Asp Trp Gly Pro Arg 
        755                 760                 765             


Phe Lys Arg Leu Ala Asp Met Tyr Gly Thr Gly Gln Glu Ser Leu Tyr 
    770                 775                 780                 


Ser 
785 


<210>  124
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  125
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Glu 
305                 310                 315                 320 


Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp 
                325                 330                 335     


Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr 
            340                 345                 350         


Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu 
        355                 360                 365             


Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg 
    370                 375                 380                 


Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val 
385                 390                 395                 400 


Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp 
                405                 410                 415     


Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu 
            420                 425                 430         


Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp 
        435                 440                 445             


Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser 
    450                 455                 460                 


Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn 
465                 470                 475                 480 


Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser 
                485                 490                 495     


Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val 
            500                 505                 510         


Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn 
        515                 520                 525             


Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro 
    530                 535                 540                 


Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val 
545                 550                 555                 560 


Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val 
                565                 570                 575     


Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro 
            580                 585                 590         


Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala 
        595                 600                 605             


Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr 
    610                 615                 620                 


Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe 
625                 630                 635                 640 


Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val 
                645                 650                 655     


Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr 
            660                 665                 670         


Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val 
        675                 680                 685             


Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700     


<210>  126
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  127
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly 
305                 310                 315                 320 


Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly 
                325                 330                 335     


Val Leu Ala Arg Val Ala Leu Ile 
            340                 


<210>  128
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Glu Glu Phe Val Gly Leu Arg Glu Gly Ser Ser Gly Asn Pro Val 
1               5                   10                  15      


Thr Leu Gln Glu Leu Trp Gly Pro Cys Pro Arg Ile Arg Arg Gly Ile 
            20                  25                  30          


Arg Gly Gly Leu Glu Trp Leu Lys Gln Lys Leu Phe Arg Leu Gly Glu 
        35                  40                  45              


Asp Trp Tyr Phe Leu Met Thr Leu Gly Val Leu Met Ala Leu Val Ser 
    50                  55                  60                  


Cys Ala Met Asp Leu Ala Val Glu Ser Val Val Arg Ala His Gln Trp 
65                  70                  75                  80  


Leu Tyr Arg Glu Ile Gly Asp Ser His Leu Leu Arg Tyr Leu Ser Trp 
                85                  90                  95      


Thr Val Tyr Pro Val Ala Leu Val Ser Phe Ser Ser Gly Phe Ser Gln 
            100                 105                 110         


Ser Ile Thr Pro Ser Ser Gly Gly Ser Gly Ile Pro Glu Val Lys Thr 
        115                 120                 125             


Met Leu Ala Gly Val Val Leu Glu Asp Tyr Leu Asp Ile Lys Asn Phe 
    130                 135                 140                 


Gly Ala Lys Val Val Gly Leu Ser Cys Thr Leu Ala Cys Gly Ser Thr 
145                 150                 155                 160 


Leu Phe Leu Gly Lys Val Gly Pro Phe Val His Leu Ser Val Met Met 
                165                 170                 175     


Ala Ala Tyr Leu Gly Arg Val Arg Thr Thr Thr Ile Gly Glu Pro Glu 
            180                 185                 190         


Asn Lys Ser Lys Gln Asn Glu Met Leu Val Ala Ala Ala Ala Val Gly 
        195                 200                 205             


Val Ala Thr Val Phe Ala Ala Pro Phe Ser Gly Val Leu Phe Ser Ile 
    210                 215                 220                 


Glu Val Met Ser Ser His Phe Ser Val Trp Asp Tyr Trp Arg Gly Phe 
225                 230                 235                 240 


Phe Ala Ala Thr Cys Gly Ala Phe Met Phe Arg Leu Leu Ala Val Phe 
                245                 250                 255     


Asn Ser Glu Gln Glu Thr Ile Thr Ser Leu Tyr Lys Thr Ser Phe Arg 
            260                 265                 270         


Val Asp Val Pro Phe Asp Leu Pro Glu Ile Phe Phe Phe Val Ala Leu 
        275                 280                 285             


Gly Gly Leu Cys Gly Ile Leu Gly Ser Ala Tyr Leu Phe Cys Gln Arg 
    290                 295                 300                 


Ile Phe Phe Gly Phe Ile Arg Asn Asn Arg Phe Ser Ser Lys Leu Leu 
305                 310                 315                 320 


Ala Thr Ser Lys Pro Val Tyr Ser Ala Leu Ala Thr Leu Val Leu Ala 
                325                 330                 335     


Ser Ile Thr Tyr Pro Pro Ser Ala Gly Arg Phe Leu Ala Ser Arg Leu 
            340                 345                 350         


Ser Met Lys Gln His Leu Asp Ser Leu Phe Asp Asn His Ser Trp Ala 
        355                 360                 365             


Leu Met Thr Gln Asn Ser Ser Pro Pro Trp Pro Glu Glu Leu Asp Pro 
    370                 375                 380                 


Gln His Leu Trp Trp Glu Trp Tyr His Pro Arg Phe Thr Ile Phe Gly 
385                 390                 395                 400 


Thr Leu Ala Phe Phe Leu Val Met Lys Phe Trp Met Leu Ile Leu Ala 
                405                 410                 415     


Thr Thr Ile Pro Met Pro Ala Gly Tyr Phe Met Pro Ile Phe Val Tyr 
            420                 425                 430         


Gly Ala Ala Ile Gly Arg Leu Phe Gly Glu Thr Leu Ser Phe Ile Phe 
        435                 440                 445             


Pro Glu Gly Ile Val Ala Gly Gly Ile Thr Asn Pro Ile Met Pro Gly 
    450                 455                 460                 


Gly Tyr Ala Leu Ala Gly Ala Ala Ala Phe Ser Gly Ala Val Thr His 
465                 470                 475                 480 


Thr Ile Ser Thr Ala Leu Leu Ala Phe Glu Val Thr Gly Gln Ile Val 
                485                 490                 495     


His Ala Leu Pro Val Leu Met Ala Val Leu Ala Ala Asn Ala Ile Ala 
            500                 505                 510         


Gln Ser Cys Gln Pro Ser Phe Tyr Asp Gly Thr Val Ile Val Lys Lys 
        515                 520                 525             


Leu Pro Tyr Leu Pro Arg Ile Leu Gly Arg Asn Ile Gly Ser His Arg 
    530                 535                 540                 


Val Arg Val Glu His Phe Met Asn His Ser Ile Thr Thr Leu Ala Lys 
545                 550                 555                 560 


Asp Met Pro Leu Glu Glu Val Val Lys Val Val Thr Ser Thr Asp Val 
                565                 570                 575     


Ala Lys Tyr Pro Leu Val Glu Ser Thr Glu Ser Gln Ile Leu Val Gly 
            580                 585                 590         


Ile Val Arg Arg Ala Gln Leu Val Gln Ala Leu Lys Ala Glu Pro Pro 
        595                 600                 605             


Ser Trp Ala Pro Gly His Gln Gln Cys Leu Gln Asp Ile Leu Ala Ala 
    610                 615                 620                 


Gly Cys Pro Thr Glu Pro Val Thr Leu Lys Leu Ser Pro Glu Thr Ser 
625                 630                 635                 640 


Leu His Glu Ala His Asn Leu Phe Glu Leu Leu Asn Leu His Ser Leu 
                645                 650                 655     


Phe Val Thr Ser Arg Gly Arg Ala Val Gly Cys Val Ser Trp Val Glu 
            660                 665                 670         


Met Lys Lys Ala Ile Ser Asn Leu Thr Asn Pro Pro Ala Pro Lys 
        675                 680                 685         


<210>  129
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Pro Cys Pro Pro Leu Leu Ser Val Pro Val Arg Ala Ala Gly Glu 
1               5                   10                  15      


Gln Asp Arg Trp Val Arg Glu Glu Val Thr Trp Gly Gly Gly Pro Thr 
            20                  25                  30          


Val Thr Gly Gly Trp Gly Trp Arg Ala His Leu Arg Ser Val Ser Pro 
        35                  40                  45              


Pro Gly Val Leu Phe Ser Ile Glu Val Met Ser Ser His Phe Ser Val 
    50                  55                  60                  


Trp Asp Tyr Trp Arg Gly Phe Phe Ala Ala Thr Cys Gly Ala Phe Met 
65                  70                  75                  80  


Phe Arg Leu Leu Ala Val Phe Asn Ser Glu Gln Glu Thr Ile Thr Ser 
                85                  90                  95      


Leu Tyr Lys Thr Ser Phe Arg Val Asp Val Pro Phe Asp Leu Pro Glu 
            100                 105                 110         


Ile Phe Phe Phe Val Ala Leu Gly Gly Leu Cys Gly Ile Leu Gly Ser 
        115                 120                 125             


Ala Tyr Leu Phe Cys Gln Arg Ile Phe Phe Gly Phe Ile Arg Asn Asn 
    130                 135                 140                 


Arg Phe Ser Ser Lys Leu Leu Ala Thr Ser Lys Pro Val Tyr Ser Ala 
145                 150                 155                 160 


Leu Ala Thr Leu Val Leu Ala Ser Ile Thr Tyr Pro Pro Ser Ala Gly 
                165                 170                 175     


Arg Phe Leu Ala Ser Arg Leu Ser Met Lys Gln His Leu Asp Ser Leu 
            180                 185                 190         


Phe Asp Asn His Ser Trp Ala Leu Met Thr Gln Asn Ser Ser Pro Pro 
        195                 200                 205             


Trp Pro Glu Glu Leu Asp Pro Gln His Leu Trp Trp Glu Trp Tyr His 
    210                 215                 220                 


Pro Arg Phe Thr Ile Phe Gly Thr Leu Ala Phe Phe Leu Val Met Lys 
225                 230                 235                 240 


Phe Trp Met Leu Ile Leu Ala Thr Thr Ile Pro Met Pro Ala Gly Tyr 
                245                 250                 255     


Phe Met Pro Ile Phe Val Tyr Gly Ala Ala Ile Gly Arg Leu Phe Gly 
            260                 265                 270         


Glu Thr Leu Ser Phe Ile Phe Pro Glu Gly Ile Val Ala Gly Gly Ile 
        275                 280                 285             


Thr Asn Pro Ile Met Pro Gly Gly Tyr Ala Leu Ala Gly Ala Ala Ala 
    290                 295                 300                 


Phe Ser Gly Ala Val Thr His Thr Ile Ser Thr Ala Leu Leu Ala Phe 
305                 310                 315                 320 


Glu Val Thr Gly Gln Ile Val His Ala Leu Pro Val Leu Met Ala Val 
                325                 330                 335     


Leu Ala Ala Asn Ala Ile Ala Gln Ser Cys Gln Pro Ser Phe Tyr Asp 
            340                 345                 350         


Gly Thr Val Ile Val Lys Lys Leu Pro Tyr Leu Pro Arg Ile Leu Gly 
        355                 360                 365             


Arg Asn Ile Gly Ser His Arg Val Arg Val Glu His Phe Met Asn His 
    370                 375                 380                 


Ser Ile Thr Thr Leu Ala Lys Asp Met Pro Leu Glu Glu Val Val Lys 
385                 390                 395                 400 


Val Val Thr Ser Thr Asp Val Ala Lys Tyr Pro Leu Val Glu Ser Thr 
                405                 410                 415     


Glu Ser Gln Ile Leu Val Gly Ile Val Arg Arg Ala Gln Leu Val Gln 
            420                 425                 430         


Ala Leu Lys Ala Glu Pro Pro Ser Trp Ala Pro Gly His Gln Cys Leu 
        435                 440                 445             


Gln Asp Ile Leu Ala Ala Gly Cys Pro Thr Glu Pro Val Thr Leu Lys 
    450                 455                 460                 


Leu Ser Pro Glu Thr Ser Leu His Glu Ala His Asn Leu Phe Glu Leu 
465                 470                 475                 480 


Leu Asn Leu His Ser Leu Phe Val Thr Ser Arg Gly Arg Ala Val Gly 
                485                 490                 495     


Cys Val Ser Trp Val Glu Met Lys Lys Ala Ile Ser Asn Leu Thr Asn 
            500                 505                 510         


Pro Pro Ala Pro Lys 
        515         


<210>  130
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ser Met Ala Val Glu Thr Phe Gly Phe Phe Met Ala Thr Val Gly 
1               5                   10                  15      


Leu Leu Met Leu Gly Val Thr Leu Pro Asn Ser Tyr Trp Arg Val Ser 
            20                  25                  30          


Thr Val His Gly Asn Val Ile Thr Thr Asn Thr Ile Phe Glu Asn Leu 
        35                  40                  45              


Trp Phe Ser Cys Ala Thr Asp Ser Leu Gly Val Tyr Asn Cys Trp Glu 
    50                  55                  60                  


Phe Pro Ser Met Leu Ala Leu Ser Gly Tyr Ile Gln Ala Cys Arg Ala 
65                  70                  75                  80  


Leu Met Ile Thr Ala Ile Leu Leu Gly Phe Leu Gly Leu Leu Leu Gly 
                85                  90                  95      


Ile Ala Gly Leu Arg Cys Thr Asn Ile Gly Gly Leu Glu Leu Ser Arg 
            100                 105                 110         


Lys Ala Lys Leu Ala Ala Thr Ala Gly Ala Leu His Ile Leu Ala Gly 
        115                 120                 125             


Ile Cys Gly Met Val Ala Ile Ser Trp Tyr Ala Phe Asn Ile Thr Arg 
    130                 135                 140                 


Asp Phe Phe Asp Pro Leu Tyr Pro Gly Thr Lys Tyr Glu Leu Gly Pro 
145                 150                 155                 160 


Ala Leu Tyr Leu Gly Trp Ser Ala Ser Leu Ile Ser Ile Leu Gly Gly 
                165                 170                 175     


Leu Cys Leu Cys Ser Ala Cys Cys Cys Gly Ser Asp Glu Asp Pro Ala 
            180                 185                 190         


Ala Ser Ala Arg Arg Pro Tyr Gln Ala Pro Val Ser Val Met Pro Val 
        195                 200                 205             


Ala Thr Ser Asp Gln Glu Gly Asp Ser Ser Phe Gly Lys Tyr Gly Arg 
    210                 215                 220                 


Asn Ala Tyr Val 
225             


<210>  131
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Ser Met Ala Val Glu Thr Phe Gly Phe Phe Met Ala Thr Val Gly 
1               5                   10                  15      


Leu Leu Met Leu Gly Val Thr Leu Pro Asn Ser Tyr Trp Arg Val Ser 
            20                  25                  30          


Thr Val His Gly Asn Val Ile Thr Thr Asn Thr Ile Phe Glu Asn Leu 
        35                  40                  45              


Trp Phe Ser Cys Ala Thr Asp Ser Leu Gly Val Tyr Asn Cys Trp Glu 
    50                  55                  60                  


Phe Pro Ser Met Leu Ala Leu Ser Gly Tyr Ile Gln Ala Cys Arg Ala 
65                  70                  75                  80  


Leu Met Ile Thr Ala Ile Leu Leu Gly Phe Leu Gly Leu Leu Leu Gly 
                85                  90                  95      


Ile Ala Gly Leu Arg Cys Thr Asn Ile Gly Gly Leu Glu Leu Ser Arg 
            100                 105                 110         


Lys Ala Lys Leu Ala Ala Thr Ala Gly Ala Leu His Ile Leu Ala Gly 
        115                 120                 125             


Ile Cys Gly Met Val Ala Ile Ser Trp Tyr Ala Phe Asn Ile Thr Arg 
    130                 135                 140                 


Asp Phe Phe Asp Pro Leu Tyr Pro Gly Thr Lys Tyr Glu Leu Gly Pro 
145                 150                 155                 160 


Ala Leu Tyr Leu Gly Trp Ser Ala Ser Leu Ile Ser Ile Leu Gly Gly 
                165                 170                 175     


Leu Cys Leu Cys Ser Ala Cys Cys Cys Gly Ser Asp Glu Asp Pro Ala 
            180                 185                 190         


Ala Ser Ala Arg Arg Pro Tyr Gln Ala Pro Val Ser Val Met Pro Val 
        195                 200                 205             


Ala Thr Ser Asp Gln Glu Gly Asp Ser Ser Phe Gly Lys Tyr Gly Arg 
    210                 215                 220                 


Asn Ala Tyr Val 
225             


<210>  132
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ala Val Thr Ala Cys Gln Gly Leu Gly Phe Val Val Ser Leu Ile 
1               5                   10                  15      


Gly Ile Ala Gly Ile Ile Ala Ala Thr Cys Met Asp Gln Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Gly Tyr Phe Thr Leu Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  133
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Ser Thr Thr Thr Cys Gln Val Val Ala Phe Leu Leu Ser Ile Leu 
1               5                   10                  15      


Gly Leu Ala Gly Cys Ile Ala Ala Thr Gly Met Asp Met Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asp Asn Pro Val Thr Ser Val Phe Gln Tyr Glu Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Gln Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Pro Tyr Phe Thr Ile Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  134
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu 
1               5                   10                  15      


Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr 
            20                  25                  30          


Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys 
    50                  55                  60                  


Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala 
65                  70                  75                  80  


Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile 
                85                  90                  95      


Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg 
            100                 105                 110         


Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly 
        115                 120                 125             


Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu 
    130                 135                 140                 


Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile 
                165                 170                 175     


Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser 
            180                 185                 190         


Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser 
        195                 200                 205             


Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Gly Tyr Val 
225                 230 


<210>  135
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu 
1               5                   10                  15      


Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr 
            20                  25                  30          


Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys 
    50                  55                  60                  


Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala 
65                  70                  75                  80  


Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile 
                85                  90                  95      


Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg 
            100                 105                 110         


Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly 
        115                 120                 125             


Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu 
    130                 135                 140                 


Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile 
                165                 170                 175     


Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser 
            180                 185                 190         


Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser 
        195                 200                 205             


Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Gly Tyr Val 
225                 230 


<210>  136
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu 
1               5                   10                  15      


Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr 
            20                  25                  30          


Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys 
    50                  55                  60                  


Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala 
65                  70                  75                  80  


Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile 
                85                  90                  95      


Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg 
            100                 105                 110         


Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly 
        115                 120                 125             


Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu 
    130                 135                 140                 


Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile 
                165                 170                 175     


Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser 
            180                 185                 190         


Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser 
        195                 200                 205             


Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Gly Tyr Val 
225                 230 


<210>  137
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Ser Met Gly Leu Glu Ile Thr Gly Thr Ala Leu Ala Val Leu Gly 
1               5                   10                  15      


Trp Leu Gly Thr Ile Val Cys Cys Ala Leu Pro Met Trp Arg Val Ser 
            20                  25                  30          


Ala Phe Ile Gly Ser Asn Ile Ile Thr Ser Gln Asn Ile Trp Glu Gly 
        35                  40                  45              


Leu Trp Met Asn Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys Lys 
    50                  55                  60                  


Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala Arg 
65                  70                  75                  80  


Ala Leu Ile Val Val Ala Ile Leu Leu Ala Ala Phe Gly Leu Leu Val 
                85                  90                  95      


Ala Leu Val Gly Ala Gln Cys Thr Asn Cys Val Gln Asp Asp Thr Ala 
            100                 105                 110         


Lys Ala Lys Ile Thr Ile Val Ala Gly Val Leu Phe Leu Leu Ala Ala 
        115                 120                 125             


Leu Leu Thr Leu Val Pro Val Ser Trp Ser Ala Asn Thr Ile Ile Arg 
    130                 135                 140                 


Asp Phe Tyr Asn Pro Val Val Pro Glu Ala Gln Lys Arg Glu Met Gly 
145                 150                 155                 160 


Ala Gly Leu Tyr Val Gly Trp Ala Ala Ala Ala Leu Gln Leu Leu Gly 
                165                 170                 175     


Gly Ala Leu Leu Cys Cys Ser Cys Pro Pro Arg Glu Lys Lys Tyr Thr 
            180                 185                 190         


Ala Thr Lys Val Val Tyr Ser Ala Pro Arg Ser Thr Gly Pro Gly Ala 
        195                 200                 205             


Ser Leu Gly Thr Gly Tyr Asp Arg Lys Asp Tyr Val 
    210                 215                 220 


<210>  138
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln Phe 
            20                  25                  30          


Gln Gln Ile His Gly His Lys Ser Ser Thr Gly Cys Leu Gly His Gly 
        35                  40                  45              


Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val Leu 
    50                  55                  60                  


Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser Gln 
65                  70                  75                  80  


Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu Lys 
                85                  90                  95      


Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr 
            100                 105                 110         


Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys 
        115                 120                 125             


Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala 
    130                 135                 140                 


Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu 
145                 150                 155                 160 


Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys 
                165                 170                 175     


Leu Gln Glu Ile Tyr Gln Glu Leu Thr Glu Leu Lys Ala Ala Val Gly 
            180                 185                 190         


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
        195                 200                 205             


Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Asp Gln Ser Lys Gln Gln 
    210                 215                 220                 


Gln Ile Tyr Gln Glu Leu Thr Asp Leu Lys Thr Ala Phe Glu Arg Leu 
225                 230                 235                 240 


Cys Arg His Cys Pro Lys Asp Trp Thr Phe Phe Gln Gly Asn Cys Tyr 
                245                 250                 255     


Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser Val Thr Ala Cys 
            260                 265                 270         


Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys Thr Ala Glu Glu Gln 
        275                 280                 285             


Asn Phe Leu Gln Leu Gln Thr Ser Arg Ser Asn Arg Phe Ser Trp Met 
    290                 295                 300                 


Gly Leu Ser Asp Leu Asn Gln Glu Gly Thr Trp Gln Trp Val Asp Gly 
305                 310                 315                 320 


Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp Asn Ser Gly Glu Pro 
                325                 330                 335     


Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe Ser Gly Ser Gly Trp 
            340                 345                 350         


Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp Ile Cys Lys Lys Pro 
        355                 360                 365             


Ala Ala Cys Phe Arg Asp Glu 
    370                 375 


<210>  139
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Val Pro Phe Leu Leu 
        35                  40                  45              


Gly Pro Val Ser Lys Val Pro Ser Ser Leu Ser Gln Glu Gln Ser Glu 
    50                  55                  60                  


Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu Lys Ala Ala Val Gly 
65                  70                  75                  80  


Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
                85                  90                  95      


Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
            100                 105                 110         


Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Glu Arg Leu 
        115                 120                 125             


Cys Arg His Cys Pro Lys Asp Trp Thr Phe Phe Gln Gly Asn Cys Tyr 
    130                 135                 140                 


Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser Val Thr Ala Cys 
145                 150                 155                 160 


Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys Thr Ala Glu Glu Gln 
                165                 170                 175     


Asn Phe Leu Gln Leu Gln Thr Ser Arg Ser Asn Arg Phe Ser Trp Met 
            180                 185                 190         


Gly Leu Ser Asp Leu Asn Gln Glu Gly Thr Trp Gln Trp Val Asp Gly 
        195                 200                 205             


Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp Asn Ser Gly Glu Pro 
    210                 215                 220                 


Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe Ser Gly Ser Gly Trp 
225                 230                 235                 240 


Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp Ile Cys Lys Lys Pro 
                245                 250                 255     


Ala Ala Cys Phe Arg Asp Glu 
            260             


<210>  140
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Val Pro Phe Leu Leu 
        35                  40                  45              


Gly Pro Val Ser Lys Val Pro Ser Ser Leu Ser Gln Glu Gln Ser Glu 
    50                  55                  60                  


Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu Lys Ala Ala Val Gly 
65                  70                  75                  80  


Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
                85                  90                  95      


Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
            100                 105                 110         


Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu 
        115                 120                 125             


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu 
    130                 135                 140                 


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
145                 150                 155                 160 


Tyr Gln Glu Leu Thr Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
                165                 170                 175     


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala 
            180                 185                 190         


Ala Val Glu Arg Leu Cys Arg His Cys Pro Lys Asp Trp Thr Phe Phe 
        195                 200                 205             


Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp 
    210                 215                 220                 


Ser Val Thr Ala Cys Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys 
225                 230                 235                 240 


Thr Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Thr Ser Arg Ser Asn 
                245                 250                 255     


Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Thr Trp 
            260                 265                 270         


Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp 
        275                 280                 285             


Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe 
    290                 295                 300                 


Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp 
305                 310                 315                 320 


Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp Glu 
                325                 330         


<210>  141
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Thr Arg Leu Lys Ala Ala Val Glu Arg Leu Cys Arg His Cys 
                165                 170                 175     


Pro Lys Asp Trp Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
            180                 185                 190         


Ser Gln Arg Asn Trp His Asp Ser Val Thr Ala Cys Gln Glu Val Arg 
        195                 200                 205             


Ala Gln Leu Val Val Ile Lys Thr Ala Glu Glu Gln Leu Pro Ala Val 
    210                 215                 220                 


Leu Glu Gln Trp Arg Thr Gln Gln 
225                 230         


<210>  142
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser 
                165                 170                 175     


Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val 
            180                 185                 190         


Gly Glu Leu Pro Asp Gln Ser Lys Gln Gln Gln Ile Tyr Gln Glu Leu 
        195                 200                 205             


Thr Asp Leu Lys Thr Ala Phe Glu Arg Leu Cys Arg His Cys Pro Lys 
    210                 215                 220                 


Asp Trp Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln 
225                 230                 235                 240 


Arg Asn Trp His Asp Ser Val Thr Ala Cys Gln Glu Val Arg Ala Gln 
                245                 250                 255     


Leu Val Val Ile Lys Thr Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln 
            260                 265                 270         


Thr Ser Arg Ser Asn Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn 
        275                 280                 285             


Gln Glu Gly Thr Trp Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser 
    290                 295                 300                 


Phe Gln Arg Tyr Trp Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu 
305                 310                 315                 320 


Asp Cys Ala Glu Phe Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp 
                325                 330                 335     


Val Asp Asn Tyr Trp Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp 
            340                 345                 350         


Glu 
    


<210>  143
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser 
                165                 170                 175     


Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Glu Leu Lys Ala Ala Val 
            180                 185                 190         


Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu 
        195                 200                 205             


Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Asp Gln Ser Lys Gln 
    210                 215                 220                 


Gln Gln Ile Tyr Gln Glu Leu Thr Asp Leu Lys Thr Ala Phe Glu Arg 
225                 230                 235                 240 


Leu Cys Arg His Cys Pro Lys Asp Trp Thr Phe Phe Gln Gly Asn Cys 
                245                 250                 255     


Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser Val Thr Ala 
            260                 265                 270         


Cys Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys Thr Ala Glu Glu 
        275                 280                 285             


Gln Asn Phe Leu Gln Leu Gln Thr Ser Arg Ser Asn Arg Phe Ser Trp 
    290                 295                 300                 


Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Thr Trp Gln Trp Val Asp 
305                 310                 315                 320 


Gly Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp Asn Ser Gly Glu 
                325                 330                 335     


Pro Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe Ser Gly Ser Gly 
            340                 345                 350         


Trp Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp Ile Cys Lys Lys 
        355                 360                 365             


Pro Ala Ala Cys Phe Arg Asp Glu 
    370                 375     


<210>  144
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Gly 
1               5                   10                  15      


Cys Leu Gly His Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu 
            20                  25                  30          


Leu Ala Gly Val Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro 
        35                  40                  45              


Ser Ser Leu Ser Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn 
    50                  55                  60                  


Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
65                  70                  75                  80  


Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly 
                85                  90                  95      


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
            100                 105                 110         


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
        115                 120                 125             


Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu 
    130                 135                 140                 


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu 
145                 150                 155                 160 


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
                165                 170                 175     


Tyr Gln Glu Leu Thr Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
            180                 185                 190         


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala 
        195                 200                 205             


Ala Val Gly Glu Leu Pro Asp Gln Ser Lys Gln Gln Gln Ile Tyr Gln 
    210                 215                 220                 


Glu Leu Thr Asp Leu Lys Thr Ala Phe Glu Arg Leu Cys Arg His Cys 
225                 230                 235                 240 


Pro Lys Asp Trp Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
                245                 250                 255     


Ser Gln Arg Asn Trp His Asp Ser Val Thr Ala Cys Gln Glu Val Arg 
            260                 265                 270         


Ala Gln Leu Val Val Ile Lys Thr Ala Glu Glu Gln Leu Pro Ala Val 
        275                 280                 285             


Leu Glu Gln Trp Arg Thr Gln Gln 
    290                 295     


<210>  145
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser 
                165                 170                 175     


Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val 
            180                 185                 190         


Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu 
        195                 200                 205             


Thr Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu 
    210                 215                 220                 


Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu 
225                 230                 235                 240 


Leu Pro Asp Gln Ser Lys Gln Gln Gln Ile Tyr Gln Glu Leu Thr Asp 
                245                 250                 255     


Leu Lys Thr Ala Phe Glu Arg Leu Cys Arg His Cys Pro Lys Asp Trp 
            260                 265                 270         


Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn 
        275                 280                 285             


Trp His Asp Ser Val Thr Ala Cys Gln Glu Val Arg Ala Gln Leu Val 
    290                 295                 300                 


Val Ile Lys Thr Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Thr Ser 
305                 310                 315                 320 


Arg Ser Asn Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn Gln Glu 
                325                 330                 335     


Gly Thr Trp Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser Phe Gln 
            340                 345                 350         


Arg Tyr Trp Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu Asp Cys 
        355                 360                 365             


Ala Glu Phe Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp Val Asp 
    370                 375                 380                 


Asn Tyr Trp Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp Glu 
385                 390                 395                 


<210>  146
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Lys Ser His Leu Ala Ile Val 
                405                 410                 415     


Gln Lys Val Asn Asn Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu 
            420                 425                 430         


Gly Leu Val Thr Leu Glu Asp Val Ile Glu Glu Ile Ile Arg Ser Glu 
        435                 440                 445             


Ile Leu Asp Glu Ser Glu Asp Tyr Arg Asp Thr Val Val Lys Arg Lys 
    450                 455                 460                 


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
465                 470                 475                 480 


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
                485                 490                 495     


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
            500                 505                 510         


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
        515                 520                 525             


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
    530                 535                 540                 


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
545                 550                 555                 560 


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
                565                 570                 575     


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
            580                 585                 590         


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
        595                 600                 605             


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
    610                 615                 620                 


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
625                 630                 635                 640 


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
                645                 650                 655     


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
            660                 665                 670         


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
        675                 680                 685             


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
    690                 695                 700                 


Pro Gly Val 
705         


<210>  147
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Asp Thr Val Val Lys Arg Lys 
                405                 410                 415     


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
            420                 425                 430         


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
        435                 440                 445             


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
    450                 455                 460                 


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
465                 470                 475                 480 


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
                485                 490                 495     


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
            500                 505                 510         


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
        515                 520                 525             


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
    530                 535                 540                 


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
545                 550                 555                 560 


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
                565                 570                 575     


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
            580                 585                 590         


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
        595                 600                 605             


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
    610                 615                 620                 


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
625                 630                 635                 640 


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
                645                 650                 655     


Pro Gly Val 
            


<210>  148
<211>  1294
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe 
1               5                   10                  15      


Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Thr 
            20                  25                  30          


Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Thr Cys Lys Asp Phe 
        35                  40                  45              


Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Thr Ala Asn Asn Leu Asp 
    50                  55                  60                  


Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln 
65                  70                  75                  80  


Gly Ser Ala Thr Cys Val Asn Thr Pro Gly Glu Arg Ser Phe Leu Cys 
                85                  90                  95      


Lys Cys Pro Pro Gly Tyr Ser Gly Thr Ile Cys Glu Thr Thr Ile Gly 
            100                 105                 110         


Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp 
        115                 120                 125             


Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe 
    130                 135                 140                 


Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro 
                165                 170                 175     


Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser 
            180                 185                 190         


Asp Pro Cys Lys Asn Glu Ala Thr Cys Leu Asn Glu Ile Gly Arg Tyr 
        195                 200                 205             


Thr Cys Ile Cys Pro His Asn Tyr Ser Gly Tyr Thr Gly Ala Gln Cys 
    210                 215                 220                 


Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly 
225                 230                 235                 240 


Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Thr Gly 
                245                 250                 255     


Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile 
            260                 265                 270         


Cys Gln Pro Gly Phe Thr Gly Ile His Cys Glu Glu Asp Val Asn Glu 
        275                 280                 285             


Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Thr Cys Glu Asn Leu Pro 
    290                 295                 300                 


Gly Asn Tyr Thr Cys His Cys Pro Phe Asp Asn Leu Ser Arg Thr Phe 
305                 310                 315                 320 


Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Thr His Gln 
                325                 330                 335     


Gln Cys Leu Asn Asn Gly Thr Cys Ile Pro His Phe Gln Asp Gly Gln 
            340                 345                 350         


His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Thr Gly Ser Leu Cys 
        355                 360                 365             


Glu Ile Ala Thr Thr Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val 
    370                 375                 380                 


Lys Ser Gly Ser Val Thr Thr Lys Gly Ser Val Cys Asn Ile Ala Leu 
385                 390                 395                 400 


Arg Phe Gln Thr Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn 
                405                 410                 415     


Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu 
            420                 425                 430         


Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His 
        435                 440                 445             


Asn Thr Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu 
    450                 455                 460                 


Ala Val Thr Leu Thr Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile 
465                 470                 475                 480 


Ala Lys Ala Pro Thr Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe 
                485                 490                 495     


Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Thr Ser Asn Gly 
            500                 505                 510         


Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Thr Pro Ser Phe Val 
        515                 520                 525             


Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Thr Leu Glu 
    530                 535                 540                 


Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg 
545                 550                 555                 560 


Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile 
                565                 570                 575     


Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly 
            580                 585                 590         


Pro Asn Cys Leu Arg Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp 
        595                 600                 605             


Ser Thr Gly Tyr Val Ile Phe Thr Leu Asp Glu Ser Tyr Gly Asp Thr 
    610                 615                 620                 


Ile Ser Leu Ser Met Phe Val Arg Thr Leu Gln Pro Ser Gly Leu Leu 
625                 630                 635                 640 


Leu Ala Leu Glu Asn Ser Thr Tyr Gln Tyr Ile Arg Val Trp Leu Glu 
                645                 650                 655     


Arg Gly Arg Leu Ala Met Leu Thr Pro Asn Ser Pro Lys Leu Val Val 
            660                 665                 670         


Lys Phe Val Leu Asn Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile 
        675                 680                 685             


Lys Pro Tyr Lys Ile Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe 
    690                 695                 700                 


Ile Ser Ala Ser Thr Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile 
705                 710                 715                 720 


Gly Gly Leu Pro Asp Lys Gln Glu Thr Glu Leu Asn Gly Gly Phe Phe 
                725                 730                 735     


Lys Gly Cys Ile Gln Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe 
            740                 745                 750         


Phe Pro Asn Pro Thr Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn 
        755                 760                 765             


Val Thr Gln Gly Cys Ala Gly Asp Asn Ser Cys Lys Ser Asn Pro Cys 
    770                 775                 780                 


His Asn Gly Gly Val Cys His Ser Arg Trp Asp Asp Phe Ser Cys Ser 
785                 790                 795                 800 


Cys Pro Ala Leu Thr Ser Gly Lys Ala Cys Glu Glu Val Gln Trp Cys 
                805                 810                 815     


Gly Phe Ser Pro Cys Pro His Gly Ala Gln Cys Gln Pro Val Leu Gln 
            820                 825                 830         


Gly Phe Glu Cys Ile Ala Asn Ala Val Phe Asn Gly Gln Ser Gly Gln 
        835                 840                 845             


Ile Leu Phe Arg Ser Asn Gly Asn Ile Thr Arg Glu Leu Thr Asn Ile 
    850                 855                 860                 


Thr Phe Gly Phe Arg Thr Arg Asp Ala Asn Val Ile Ile Leu His Ala 
865                 870                 875                 880 


Glu Lys Glu Pro Glu Phe Leu Asn Ile Ser Ile Gln Asp Ser Arg Leu 
                885                 890                 895     


Phe Phe Gln Leu Gln Ser Gly Asn Ser Phe Tyr Met Leu Ser Leu Thr 
            900                 905                 910         


Ser Leu Gln Ser Val Asn Asp Gly Thr Trp His Glu Val Thr Leu Ser 
        915                 920                 925             


Met Thr Asp Pro Leu Ser Gln Thr Ser Arg Trp Gln Met Glu Val Asp 
    930                 935                 940                 


Asn Glu Thr Pro Phe Val Thr Ser Thr Ile Ala Thr Gly Ser Leu Asn 
945                 950                 955                 960 


Phe Leu Lys Asp Asn Thr Asp Ile Tyr Val Gly Asp Arg Ala Ile Asp 
                965                 970                 975     


Asn Ile Lys Gly Leu Gln Gly Cys Leu Ser Thr Ile Glu Ile Gly Gly 
            980                 985                 990         


Ile Tyr Leu Ser Tyr Phe Glu Asn  Val His Gly Phe Ile  Asn Lys Pro 
        995                 1000                 1005             


Gln Glu  Glu Gln Phe Leu Lys  Ile Ser Thr Asn Ser  Val Val Thr 
    1010                 1015                 1020             


Gly Cys  Leu Gln Leu Asn Val  Cys Asn Ser Asn Pro  Cys Leu His 
    1025                 1030                 1035             


Gly Gly  Asn Cys Glu Asp Ile  Tyr Ser Ser Tyr His  Cys Ser Cys 
    1040                 1045                 1050             


Pro Leu  Gly Trp Ser Gly Lys  His Cys Glu Leu Asn  Ile Asp Glu 
    1055                 1060                 1065             


Cys Phe  Ser Asn Pro Cys Ile  His Gly Asn Cys Ser  Asp Arg Val 
    1070                 1075                 1080             


Ala Ala  Tyr His Cys Thr Cys  Glu Pro Gly Tyr Thr  Gly Val Asn 
    1085                 1090                 1095             


Cys Glu  Val Asp Ile Asp Asn  Cys Gln Ser His Gln  Cys Ala Asn 
    1100                 1105                 1110             


Gly Ala  Thr Cys Ile Ser His  Thr Asn Gly Tyr Ser  Cys Leu Cys 
    1115                 1120                 1125             


Phe Gly  Asn Phe Thr Gly Lys  Phe Cys Arg Gln Ser  Arg Leu Pro 
    1130                 1135                 1140             


Ser Thr  Val Cys Gly Asn Glu  Lys Thr Asn Leu Thr  Cys Tyr Asn 
    1145                 1150                 1155             


Gly Gly  Asn Cys Thr Glu Phe  Gln Thr Glu Leu Lys  Cys Met Cys 
    1160                 1165                 1170             


Arg Pro  Gly Phe Thr Gly Glu  Trp Cys Glu Lys Asp  Ile Asp Glu 
    1175                 1180                 1185             


Cys Ala  Ser Asp Pro Cys Val  Asn Gly Gly Leu Cys  Gln Asp Leu 
    1190                 1195                 1200             


Leu Asn  Lys Phe Gln Cys Leu  Cys Asp Val Ala Phe  Ala Gly Glu 
    1205                 1210                 1215             


Arg Cys  Glu Val Asp Leu Ala  Asp Asp Leu Ile Ser  Asp Ile Phe 
    1220                 1225                 1230             


Thr Thr  Ile Gly Ser Val Thr  Val Ala Leu Leu Leu  Ile Leu Leu 
    1235                 1240                 1245             


Leu Ala  Ile Val Ala Ser Val  Val Thr Ser Asn Lys  Arg Ala Thr 
    1250                 1255                 1260             


Gln Gly  Thr Tyr Ser Pro Ser  Arg Gln Glu Lys Glu  Gly Ser Arg 
    1265                 1270                 1275             


Val Glu  Met Trp Asn Leu Met  Pro Pro Pro Ala Met  Glu Arg Leu 
    1280                 1285                 1290             


Ile 
    


<210>  149
<211>  1382
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln Gly Ser Ala Thr Cys 
1               5                   10                  15      


Val Asn Thr Pro Gly Glu Arg Ser Phe Leu Cys Lys Cys Pro Pro Gly 
            20                  25                  30          


Tyr Ser Gly Thr Ile Cys Glu Thr Thr Ile Gly Ser Cys Gly Lys Asn 
        35                  40                  45              


Ser Cys Gln His Gly Gly Ile Cys His Gln Asp Pro Ile Tyr Pro Val 
    50                  55                  60                  


Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe Cys Glu Ile Asp His 
65                  70                  75                  80  


Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly Ala Val Cys Gln Asp 
                85                  90                  95      


Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro Gly Tyr Gln Gly Arg 
            100                 105                 110         


His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser Asp Pro Cys Lys Asn 
        115                 120                 125             


Glu Ala Thr Cys Leu Asn Glu Ile Gly Arg Tyr Thr Cys Ile Cys Pro 
    130                 135                 140                 


His Asn Tyr Ser Gly Val Asn Cys Glu Leu Glu Ile Asp Glu Cys Trp 
145                 150                 155                 160 


Ser Gln Pro Cys Leu Asn Gly Ala Thr Cys Gln Asp Ala Leu Gly Ala 
                165                 170                 175     


Tyr Phe Cys Asp Cys Ala Pro Gly Phe Leu Gly Asp His Cys Glu Leu 
            180                 185                 190         


Asn Thr Asp Glu Cys Ala Ser Gln Pro Cys Leu His Gly Gly Leu Cys 
        195                 200                 205             


Val Asp Gly Glu Asn Arg Tyr Ser Cys Asn Cys Thr Gly Ser Gly Phe 
    210                 215                 220                 


Thr Gly Thr His Cys Glu Thr Leu Met Pro Leu Cys Trp Ser Lys Pro 
225                 230                 235                 240 


Cys His Asn Asn Ala Thr Cys Glu Asp Ser Val Asp Asn Tyr Thr Cys 
                245                 250                 255     


His Cys Trp Pro Gly Tyr Thr Gly Ala Gln Cys Glu Ile Asp Leu Asn 
            260                 265                 270         


Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly Glu Cys Val Glu Leu 
        275                 280                 285             


Ser Ser Glu Lys Gln Tyr Gly Arg Ile Thr Gly Leu Pro Ser Ser Phe 
    290                 295                 300                 


Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile Cys Gln Pro Gly Phe 
305                 310                 315                 320 


Thr Gly Ile His Cys Glu Glu Asp Val Asn Glu Cys Ser Ser Asn Pro 
                325                 330                 335     


Cys Gln Asn Gly Gly Thr Cys Glu Asn Leu Pro Gly Asn Tyr Thr Cys 
            340                 345                 350         


His Cys Pro Phe Asp Asn Leu Ser Arg Thr Phe Tyr Gly Gly Arg Asp 
        355                 360                 365             


Cys Ser Asp Ile Leu Leu Gly Cys Thr His Gln Gln Cys Leu Asn Asn 
    370                 375                 380                 


Gly Thr Cys Ile Pro His Phe Gln Asp Gly Gln His Gly Phe Ser Cys 
385                 390                 395                 400 


Leu Cys Pro Ser Gly Tyr Thr Gly Ser Leu Cys Glu Ile Ala Thr Thr 
                405                 410                 415     


Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val Lys Ser Gly Ser Val 
            420                 425                 430         


Thr Thr Lys Gly Ser Val Cys Asn Ile Ala Leu Arg Phe Gln Thr Val 
        435                 440                 445             


Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn Arg Asp Val Phe Val 
    450                 455                 460                 


Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu Ser Ile Gln Val Asn 
465                 470                 475                 480 


Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His Asn Thr Ser Asp Gly 
                485                 490                 495     


Glu Trp His Phe Val Glu Val Ile Phe Ala Glu Ala Val Thr Leu Thr 
            500                 505                 510         


Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile Ala Lys Ala Pro Thr 
        515                 520                 525             


Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe Gln Asn Ser Phe Leu 
    530                 535                 540                 


Gly Gly Leu Pro Val Gly Met Thr Ser Asn Gly Val Ala Leu Leu Asn 
545                 550                 555                 560 


Phe Tyr Asn Met Pro Ser Thr Pro Ser Phe Val Gly Cys Leu Gln Asp 
                565                 570                 575     


Ile Lys Ile Asp Trp Asn His Ile Thr Leu Glu Asn Ile Ser Ser Gly 
            580                 585                 590         


Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg Lys Asp Trp Cys Glu 
        595                 600                 605             


Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile Asn Leu Trp Leu Ser 
    610                 615                 620                 


Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly Pro Asn Cys Leu Arg 
625                 630                 635                 640 


Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp Ser Thr Gly Tyr Val 
                645                 650                 655     


Ile Phe Thr Leu Asp Glu Ser Tyr Gly Asp Thr Ile Ser Leu Ser Met 
            660                 665                 670         


Phe Val Arg Thr Leu Gln Pro Ser Gly Leu Leu Leu Ala Leu Glu Asn 
        675                 680                 685             


Ser Thr Tyr Gln Tyr Ile Arg Val Trp Leu Glu Arg Gly Arg Leu Ala 
    690                 695                 700                 


Met Leu Thr Pro Asn Ser Pro Lys Leu Val Val Lys Phe Val Leu Asn 
705                 710                 715                 720 


Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile Lys Pro Tyr Lys Ile 
                725                 730                 735     


Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe Ile Ser Ala Ser Thr 
            740                 745                 750         


Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile Gly Gly Leu Pro Asp 
        755                 760                 765             


Lys Gln Glu Thr Glu Leu Asn Gly Gly Phe Phe Lys Gly Cys Ile Gln 
    770                 775                 780                 


Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe Phe Pro Asn Pro Thr 
785                 790                 795                 800 


Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn Val Thr Gln Gly Cys 
                805                 810                 815     


Ala Gly Asp Asn Ser Cys Lys Arg Gln Thr Asn Val Gly Arg Ala Leu 
            820                 825                 830         


Thr Glu Leu Gly Ser Arg Gly Pro Lys Tyr Gln Val Ser Leu Phe Arg 
        835                 840                 845             


Phe Cys Val Gly Ser Trp Ala Thr Gly Asn Thr Phe Phe Leu Ser Ser 
    850                 855                 860                 


Ile Lys Pro Gly Ser Asn Pro Cys His Asn Gly Gly Val Cys His Ser 
865                 870                 875                 880 


Arg Trp Asp Asp Phe Ser Cys Ser Cys Pro Ala Leu Thr Ser Gly Lys 
                885                 890                 895     


Ala Cys Glu Glu Val Gln Trp Cys Gly Phe Ser Pro Cys Pro His Gly 
            900                 905                 910         


Ala Gln Cys Gln Pro Val Leu Gln Gly Phe Glu Cys Ile Ala Asn Ala 
        915                 920                 925             


Val Phe Asn Gly Gln Ser Gly Gln Ile Leu Phe Arg Ser Asn Gly Asn 
    930                 935                 940                 


Ile Thr Arg Glu Leu Thr Asn Ile Thr Phe Gly Phe Arg Thr Arg Asp 
945                 950                 955                 960 


Ala Asn Val Ile Ile Leu His Ala Glu Lys Glu Pro Glu Phe Leu Asn 
                965                 970                 975     


Ile Ser Ile Gln Asp Ser Arg Leu Phe Phe Gln Leu Gln Ser Gly Asn 
            980                 985                 990         


Ser Phe Tyr Met Leu Ser Leu Thr  Ser Leu Gln Ser Val  Asn Asp Gly 
        995                 1000                 1005             


Thr Trp  His Glu Val Thr Leu  Ser Met Thr Asp Pro  Leu Ser Gln 
    1010                 1015                 1020             


Thr Ser  Arg Trp Gln Met Glu  Val Asp Asn Glu Thr  Pro Phe Val 
    1025                 1030                 1035             


Thr Ser  Thr Ile Ala Thr Gly  Ser Leu Asn Phe Leu  Lys Asp Asn 
    1040                 1045                 1050             


Thr Asp  Ile Tyr Val Gly Asp  Arg Ala Ile Asp Asn  Ile Lys Gly 
    1055                 1060                 1065             


Leu Gln  Gly Cys Leu Ser Thr  Ile Glu Ile Gly Gly  Ile Tyr Leu 
    1070                 1075                 1080             


Ser Tyr  Phe Glu Asn Val His  Gly Phe Ile Asn Lys  Pro Gln Glu 
    1085                 1090                 1095             


Glu Gln  Phe Leu Lys Ile Ser  Thr Asn Ser Val Val  Thr Gly Cys 
    1100                 1105                 1110             


Leu Gln  Leu Asn Val Cys Asn  Ser Asn Pro Cys Leu  His Gly Gly 
    1115                 1120                 1125             


Asn Cys  Glu Asp Ile Tyr Ser  Ser Tyr His Cys Ser  Cys Pro Leu 
    1130                 1135                 1140             


Gly Trp  Ser Gly Lys His Cys  Glu Leu Asn Ile Asp  Glu Cys Phe 
    1145                 1150                 1155             


Ser Asn  Pro Cys Ile His Gly  Asn Cys Ser Asp Arg  Val Ala Ala 
    1160                 1165                 1170             


Tyr His  Cys Thr Cys Glu Pro  Gly Tyr Thr Gly Val  Asn Cys Glu 
    1175                 1180                 1185             


Val Asp  Ile Asp Asn Cys Gln  Ser His Gln Cys Ala  Asn Gly Ala 
    1190                 1195                 1200             


Thr Cys  Ile Ser His Thr Asn  Gly Tyr Ser Cys Leu  Cys Phe Gly 
    1205                 1210                 1215             


Asn Phe  Thr Gly Lys Phe Cys  Arg Gln Ser Arg Leu  Pro Ser Thr 
    1220                 1225                 1230             


Val Cys  Gly Asn Glu Lys Thr  Asn Leu Thr Cys Tyr  Asn Gly Gly 
    1235                 1240                 1245             


Asn Cys  Thr Glu Phe Gln Thr  Glu Leu Lys Cys Met  Cys Arg Pro 
    1250                 1255                 1260             


Gly Phe  Thr Gly Glu Trp Cys  Glu Lys Asp Ile Asp  Glu Cys Ala 
    1265                 1270                 1275             


Ser Asp  Pro Cys Val Asn Gly  Gly Leu Cys Gln Asp  Leu Leu Asn 
    1280                 1285                 1290             


Lys Phe  Gln Cys Leu Cys Asp  Val Ala Phe Ala Gly  Glu Arg Cys 
    1295                 1300                 1305             


Glu Val  Asp Leu Ala Asp Asp  Leu Ile Ser Asp Ile  Phe Thr Thr 
    1310                 1315                 1320             


Ile Gly  Ser Val Thr Val Ala  Leu Leu Leu Ile Leu  Leu Leu Ala 
    1325                 1330                 1335             


Ile Val  Ala Ser Val Val Thr  Ser Asn Lys Arg Ala  Thr Gln Gly 
    1340                 1345                 1350             


Thr Tyr  Ser Pro Ser Arg Gln  Glu Lys Glu Gly Ser  Arg Val Glu 
    1355                 1360                 1365             


Met Trp  Asn Leu Met Pro Pro  Pro Ala Met Glu Arg  Leu Ile 
    1370                 1375                 1380         


<210>  150
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe 
1               5                   10                  15      


Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Thr 
            20                  25                  30          


Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Thr Cys Lys Asp Phe 
        35                  40                  45              


Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Thr Ala Asn Asn Leu Asp 
    50                  55                  60                  


Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln 
65                  70                  75                  80  


Gly Ser Ala Thr Cys Val Asn Thr Pro Gly Glu Arg Ser Phe Leu Cys 
                85                  90                  95      


Lys Cys Pro Pro Gly Tyr Ser Gly Thr Ile Cys Glu Thr Thr Ile Gly 
            100                 105                 110         


Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp 
        115                 120                 125             


Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe 
    130                 135                 140                 


Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro 
                165                 170                 175     


Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser 
            180                 185                 190         


Asp Pro Cys Lys Asn Glu Ala Thr Cys Leu Asn Glu Ile Gly Arg Tyr 
        195                 200                 205             


Thr Cys Ile Cys Pro His Asn Tyr Ser Gly Val Asn Cys Glu Leu Glu 
    210                 215                 220                 


Ile Asp Glu Cys Trp Ser Gln Pro Cys Leu Asn Gly Ala Thr Cys Gln 
225                 230                 235                 240 


Asp Ala Leu Gly Ala Tyr Phe Cys Asp Cys Ala Pro Gly Phe Leu Gly 
                245                 250                 255     


Asp His Cys Glu Leu Asn Thr Asp Glu Cys Ala Ser Gln Pro Cys Leu 
            260                 265                 270         


His Gly Gly Leu Cys Val Asp Gly Glu Asn Arg Tyr Ser Cys Asn Cys 
        275                 280                 285             


Thr Gly Ser Gly Phe Thr Gly Thr His Cys Glu Thr Leu Met Pro Leu 
    290                 295                 300                 


Cys Trp Ser Lys Pro Cys His Asn Asn Ala Thr Cys Glu Asp Ser Val 
305                 310                 315                 320 


Asp Asn Tyr Thr Cys His Cys Trp Pro Gly Tyr Thr Gly Ala Gln Cys 
                325                 330                 335     


Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly 
            340                 345                 350         


Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Thr Gly 
        355                 360                 365             


Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile 
    370                 375                 380                 


Cys Gln Pro Gly Phe Thr Gly Ile His Cys Glu Glu Asp Val Asn Glu 
385                 390                 395                 400 


Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Thr Cys Glu Asn Leu Pro 
                405                 410                 415     


Gly Asn Tyr Thr Cys His Cys Pro Phe Asp Asn Leu Ser Arg Thr Phe 
            420                 425                 430         


Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Thr His Gln 
        435                 440                 445             


Gln Cys Leu Asn Asn Gly Thr Cys Ile Pro His Phe Gln Asp Gly Gln 
    450                 455                 460                 


His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Thr Gly Ser Leu Cys 
465                 470                 475                 480 


Glu Ile Ala Thr Thr Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val 
                485                 490                 495     


Lys Ser Gly Ser Val Thr Thr Lys Gly Ser Val Cys Asn Ile Ala Leu 
            500                 505                 510         


Arg Phe Gln Thr Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn 
        515                 520                 525             


Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu 
    530                 535                 540                 


Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His 
545                 550                 555                 560 


Asn Thr Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu 
                565                 570                 575     


Ala Val Thr Leu Thr Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile 
            580                 585                 590         


Ala Lys Ala Pro Thr Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe 
        595                 600                 605             


Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Thr Ser Asn Gly 
    610                 615                 620                 


Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Thr Pro Ser Phe Val 
625                 630                 635                 640 


Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Thr Leu Glu 
                645                 650                 655     


Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg 
            660                 665                 670         


Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile 
        675                 680                 685             


Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly 
    690                 695                 700                 


Pro Asn Cys Leu Arg Gly Lys Phe Cys Arg Gln Ser Arg Leu Pro Ser 
705                 710                 715                 720 


Thr Val Cys Gly Asn Glu Lys Thr Asn Leu Thr Cys Tyr Asn Gly Gly 
                725                 730                 735     


Asn Cys Thr Glu Phe Gln Thr Glu Leu Lys Cys Met Cys Arg Pro Gly 
            740                 745                 750         


Phe Thr Gly Glu Trp Cys Glu Lys Asp Ile Asp Glu Cys Ala Ser Asp 
        755                 760                 765             


Pro Cys Val Asn Gly Gly Leu Cys Gln Asp Leu Leu Asn Lys Phe Gln 
    770                 775                 780                 


Cys Leu Cys Asp Val Ala Phe Ala Gly Glu Arg Cys Glu Val Asp Leu 
785                 790                 795                 800 


Ala Asp Asp Leu Ile Ser Asp Ile Phe Thr Thr Ile Gly Ser Val Thr 
                805                 810                 815     


Val Ala Leu Leu Leu Ile Leu Leu Leu Ala Ile Val Ala Ser Val Val 
            820                 825                 830         


Thr Ser Asn Lys Arg Ala Thr Gln Gly Thr Tyr Ser Pro Ser Arg Gln 
        835                 840                 845             


Glu Lys Glu Gly Ser Arg Val Glu Met Trp Asn Leu Met Pro Pro Pro 
    850                 855                 860                 


Ala Met Glu Arg Leu Ile 
865                 870 


<210>  151
<211>  1406
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe 
1               5                   10                  15      


Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Thr 
            20                  25                  30          


Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Thr Cys Lys Asp Phe 
        35                  40                  45              


Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Thr Ala Asn Asn Leu Asp 
    50                  55                  60                  


Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln 
65                  70                  75                  80  


Gly Ser Ala Thr Cys Val Asn Thr Pro Gly Glu Arg Ser Phe Leu Cys 
                85                  90                  95      


Lys Cys Pro Pro Gly Tyr Ser Gly Thr Ile Cys Glu Thr Thr Ile Gly 
            100                 105                 110         


Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp 
        115                 120                 125             


Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe 
    130                 135                 140                 


Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro 
                165                 170                 175     


Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser 
            180                 185                 190         


Asp Pro Cys Lys Asn Glu Ala Thr Cys Leu Asn Glu Ile Gly Arg Tyr 
        195                 200                 205             


Thr Cys Ile Cys Pro His Asn Tyr Ser Gly Val Asn Cys Glu Leu Glu 
    210                 215                 220                 


Ile Asp Glu Cys Trp Ser Gln Pro Cys Leu Asn Gly Ala Thr Cys Gln 
225                 230                 235                 240 


Asp Ala Leu Gly Ala Tyr Phe Cys Asp Cys Ala Pro Gly Phe Leu Gly 
                245                 250                 255     


Asp His Cys Glu Leu Asn Thr Asp Glu Cys Ala Ser Gln Pro Cys Leu 
            260                 265                 270         


His Gly Gly Leu Cys Val Asp Gly Glu Asn Arg Tyr Ser Cys Asn Cys 
        275                 280                 285             


Thr Gly Ser Gly Phe Thr Gly Thr His Cys Glu Thr Leu Met Pro Leu 
    290                 295                 300                 


Cys Trp Ser Lys Pro Cys His Asn Asn Ala Thr Cys Glu Asp Ser Val 
305                 310                 315                 320 


Asp Asn Tyr Thr Cys His Cys Trp Pro Gly Tyr Thr Gly Ala Gln Cys 
                325                 330                 335     


Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly 
            340                 345                 350         


Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Thr Gly 
        355                 360                 365             


Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile 
    370                 375                 380                 


Cys Gln Pro Gly Phe Thr Gly Ile His Cys Glu Glu Asp Val Asn Glu 
385                 390                 395                 400 


Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Thr Cys Glu Asn Leu Pro 
                405                 410                 415     


Gly Asn Tyr Thr Cys His Cys Pro Phe Asp Asn Leu Ser Arg Thr Phe 
            420                 425                 430         


Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Thr His Gln 
        435                 440                 445             


Gln Cys Leu Asn Asn Gly Thr Cys Ile Pro His Phe Gln Asp Gly Gln 
    450                 455                 460                 


His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Thr Gly Ser Leu Cys 
465                 470                 475                 480 


Glu Ile Ala Thr Thr Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val 
                485                 490                 495     


Lys Ser Gly Ser Val Thr Thr Lys Gly Ser Val Cys Asn Ile Ala Leu 
            500                 505                 510         


Arg Phe Gln Thr Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn 
        515                 520                 525             


Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu 
    530                 535                 540                 


Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His 
545                 550                 555                 560 


Asn Thr Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu 
                565                 570                 575     


Ala Val Thr Leu Thr Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile 
            580                 585                 590         


Ala Lys Ala Pro Thr Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe 
        595                 600                 605             


Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Thr Ser Asn Gly 
    610                 615                 620                 


Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Thr Pro Ser Phe Val 
625                 630                 635                 640 


Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Thr Leu Glu 
                645                 650                 655     


Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg 
            660                 665                 670         


Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile 
        675                 680                 685             


Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly 
    690                 695                 700                 


Pro Asn Cys Leu Arg Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp 
705                 710                 715                 720 


Ser Thr Gly Tyr Val Ile Phe Thr Leu Asp Glu Ser Tyr Gly Asp Thr 
                725                 730                 735     


Ile Ser Leu Ser Met Phe Val Arg Thr Leu Gln Pro Ser Gly Leu Leu 
            740                 745                 750         


Leu Ala Leu Glu Asn Ser Thr Tyr Gln Tyr Ile Arg Val Trp Leu Glu 
        755                 760                 765             


Arg Gly Arg Leu Ala Met Leu Thr Pro Asn Ser Pro Lys Leu Val Val 
    770                 775                 780                 


Lys Phe Val Leu Asn Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile 
785                 790                 795                 800 


Lys Pro Tyr Lys Ile Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe 
                805                 810                 815     


Ile Ser Ala Ser Thr Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile 
            820                 825                 830         


Gly Gly Leu Pro Asp Lys Gln Glu Thr Glu Leu Asn Gly Gly Phe Phe 
        835                 840                 845             


Lys Gly Cys Ile Gln Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe 
    850                 855                 860                 


Phe Pro Asn Pro Thr Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn 
865                 870                 875                 880 


Val Thr Gln Gly Cys Ala Gly Asp Asn Ser Cys Lys Ser Asn Pro Cys 
                885                 890                 895     


His Asn Gly Gly Val Cys His Ser Arg Trp Asp Asp Phe Ser Cys Ser 
            900                 905                 910         


Cys Pro Ala Leu Thr Ser Gly Lys Ala Cys Glu Glu Val Gln Trp Cys 
        915                 920                 925             


Gly Phe Ser Pro Cys Pro His Gly Ala Gln Cys Gln Pro Val Leu Gln 
    930                 935                 940                 


Gly Phe Glu Cys Ile Ala Asn Ala Val Phe Asn Gly Gln Ser Gly Gln 
945                 950                 955                 960 


Ile Leu Phe Arg Ser Asn Gly Asn Ile Thr Arg Glu Leu Thr Asn Ile 
                965                 970                 975     


Thr Phe Gly Phe Arg Thr Arg Asp Ala Asn Val Ile Ile Leu His Ala 
            980                 985                 990         


Glu Lys Glu Pro Glu Phe Leu Asn  Ile Ser Ile Gln Asp  Ser Arg Leu 
        995                 1000                 1005             


Phe Phe  Gln Leu Gln Ser Gly  Asn Ser Phe Tyr Met  Leu Ser Leu 
    1010                 1015                 1020             


Thr Ser  Leu Gln Ser Val Asn  Asp Gly Thr Trp His  Glu Val Thr 
    1025                 1030                 1035             


Leu Ser  Met Thr Asp Pro Leu  Ser Gln Thr Ser Arg  Trp Gln Met 
    1040                 1045                 1050             


Glu Val  Asp Asn Glu Thr Pro  Phe Val Thr Ser Thr  Ile Ala Thr 
    1055                 1060                 1065             


Gly Ser  Leu Asn Phe Leu Lys  Asp Asn Thr Asp Ile  Tyr Val Gly 
    1070                 1075                 1080             


Asp Arg  Ala Ile Asp Asn Ile  Lys Gly Leu Gln Gly  Cys Leu Ser 
    1085                 1090                 1095             


Thr Ile  Glu Ile Gly Gly Ile  Tyr Leu Ser Tyr Phe  Glu Asn Val 
    1100                 1105                 1110             


His Gly  Phe Ile Asn Lys Pro  Gln Glu Glu Gln Phe  Leu Lys Ile 
    1115                 1120                 1125             


Ser Thr  Asn Ser Val Val Thr  Gly Cys Leu Gln Leu  Asn Val Cys 
    1130                 1135                 1140             


Asn Ser  Asn Pro Cys Leu His  Gly Gly Asn Cys Glu  Asp Ile Tyr 
    1145                 1150                 1155             


Ser Ser  Tyr His Cys Ser Cys  Pro Leu Gly Trp Ser  Gly Lys His 
    1160                 1165                 1170             


Cys Glu  Leu Asn Ile Asp Glu  Cys Phe Ser Asn Pro  Cys Ile His 
    1175                 1180                 1185             


Gly Asn  Cys Ser Asp Arg Val  Ala Ala Tyr His Cys  Thr Cys Glu 
    1190                 1195                 1200             


Pro Gly  Tyr Thr Gly Val Asn  Cys Glu Val Asp Ile  Asp Asn Cys 
    1205                 1210                 1215             


Gln Ser  His Gln Cys Ala Asn  Gly Ala Thr Cys Ile  Ser His Thr 
    1220                 1225                 1230             


Asn Gly  Tyr Ser Cys Leu Cys  Phe Gly Asn Phe Thr  Gly Lys Phe 
    1235                 1240                 1245             


Cys Arg  Gln Ser Arg Leu Pro  Ser Thr Val Cys Gly  Asn Glu Lys 
    1250                 1255                 1260             


Thr Asn  Leu Thr Cys Tyr Asn  Gly Gly Asn Cys Thr  Glu Phe Gln 
    1265                 1270                 1275             


Thr Glu  Leu Lys Cys Met Cys  Arg Pro Gly Phe Thr  Gly Glu Trp 
    1280                 1285                 1290             


Cys Glu  Lys Asp Ile Asp Glu  Cys Ala Ser Asp Pro  Cys Val Asn 
    1295                 1300                 1305             


Gly Gly  Leu Cys Gln Asp Leu  Leu Asn Lys Phe Gln  Cys Leu Cys 
    1310                 1315                 1320             


Asp Val  Ala Phe Ala Gly Glu  Arg Cys Glu Val Asp  Leu Ala Asp 
    1325                 1330                 1335             


Asp Leu  Ile Ser Asp Ile Phe  Thr Thr Ile Gly Ser  Val Thr Val 
    1340                 1345                 1350             


Ala Leu  Leu Leu Ile Leu Leu  Leu Ala Ile Val Ala  Ser Val Val 
    1355                 1360                 1365             


Thr Ser  Asn Lys Arg Ala Thr  Gln Gly Thr Tyr Ser  Pro Ser Arg 
    1370                 1375                 1380             


Gln Glu  Lys Glu Gly Ser Arg  Val Glu Met Trp Asn  Leu Met Pro 
    1385                 1390                 1395             


Pro Pro  Ala Met Glu Arg Leu  Ile 
    1400                 1405     


<210>  152
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Thr Ile Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu 
        675                 680                 685             


Gly Thr Pro Pro Ile Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys 
    690                 695                 700                 


Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu 
705                 710                 715                 720 


Pro Thr Leu Val Gln Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val 
                725                 730                 735     


Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr Ser Asp Gln Val Leu Tyr 
            740                 745                 750         


Gly Gln Leu Leu Gly Ser Pro Thr Ser Pro Gly Pro Gly His Tyr Leu 
        755                 760                 765             


Arg Cys Asp Ser Thr Gln Pro Leu Leu Ala Gly Leu Thr Pro Ser Pro 
    770                 775                 780                 


Lys Ser Tyr Glu Asn Leu Trp Phe Gln Ala Ser Pro Leu Gly Thr Leu 
785                 790                 795                 800 


Val Thr Pro Ala Pro Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu 
                805                 810                 815     


Leu Asn Phe Pro Leu Leu Gln Gly Ile Arg Val His Gly Met Glu Ala 
            820                 825                 830         


Leu Gly Ser Phe 
        835     


<210>  153
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Thr Ile Met Glu Glu Leu Pro Gly Pro Arg Gln Gly Gln 
        675                 680                 685             


Trp Leu Gly Gln Thr Ser Glu Met Ser Arg Ala Leu Thr Pro His Pro 
    690                 695                 700                 


Cys Val Gln Asp Ala Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile 
705                 710                 715                 720 


Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp 
                725                 730                 735     


Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln 
            740                 745                 750         


Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln 
        755                 760                 765             


Ser Gln Ser Gly Thr Ser Asp Gln Val Leu Tyr Gly Gln Leu Leu Gly 
    770                 775                 780                 


Ser Pro Thr Ser Pro Gly Pro Gly His Tyr Leu Arg Cys Asp Ser Thr 
785                 790                 795                 800 


Gln Pro Leu Leu Ala Gly Leu Thr Pro Ser Pro Lys Ser Tyr Glu Asn 
                805                 810                 815     


Leu Trp Phe Gln Ala Ser Pro Leu Gly Thr Leu Val Thr Pro Ala Pro 
            820                 825                 830         


Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu Leu Asn Phe Pro Leu 
        835                 840                 845             


Leu Gln Gly Ile Arg Val His Gly Met Glu Ala Leu Gly Ser Phe 
    850                 855                 860             


<210>  154
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Thr Ile Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu 
        675                 680                 685             


Gly Thr Pro Pro Ile Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys 
    690                 695                 700                 


Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu 
705                 710                 715                 720 


Pro Thr Leu Val Gln Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val 
                725                 730                 735     


Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr Ser Asp Gln Ala Gly Pro 
            740                 745                 750         


Pro Arg Arg Ser Ala Tyr Phe Lys Asp Gln Ile Met Leu His Pro Ala 
        755                 760                 765             


Pro Pro Asn Gly Leu Leu Cys Leu Phe Pro Ile Thr Ser Val Leu 
    770                 775                 780             


<210>  155
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210>  156
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Ser Leu Leu Ser Leu Pro Trp Leu Gly Leu Arg Pro Val Ala Thr 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Val Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Ala Phe Tyr Asn Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Trp Gly His Leu 
    50                  55                  60                  


Gly Leu Ile Thr Pro Thr Glu Glu Gly Leu Lys Asn Ser Thr Gln Met 
65                  70                  75                  80  


Ser Ala Thr Tyr Ser Gln Gly Phe Thr Val Trp Leu Gly Pro Ile Ile 
                85                  90                  95      


Pro Phe Ile Val Leu Cys His Pro Asp Thr Ile Arg Ser Ile Thr Asn 
            100                 105                 110         


Ala Ser Ala Ala Ile Ala Pro Lys Asp Asn Leu Phe Ile Arg Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Glu Gly Ile Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Ser Tyr Ile Thr Ile Phe Asn Lys Ser Ala Asn Ile Met Leu Asp 
                165                 170                 175     


Lys Trp Gln His Leu Ala Ser Glu Gly Ser Ser Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Arg Pro Ser Glu Tyr Ile Ala Thr 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Glu Lys Arg Ser Gln His Ile Leu 
225                 230                 235                 240 


Gln His Met Asp Phe Leu Tyr Tyr Leu Ser His Asp Gly Arg Arg Phe 
                245                 250                 255     


His Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Arg 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Phe Lys 
        275                 280                 285             


Asp Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Ala Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Gly Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr Asn Leu Ala Arg His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Asp Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Val Lys Glu Ser Leu Arg Leu His Pro Pro Ala Pro Phe Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Thr Cys Leu Ile Asp Ile Ile Gly Val His His Asn Pro Thr 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ser Lys Gly Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Met Leu Leu His Phe Arg Phe Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Leu Glu Leu Ile Met Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Asn Val Ser Leu Gln 
        515                 520                 


<210>  157
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Lys Ser Asp Phe Tyr Phe Gln Ala Val Tyr Thr Leu Thr Ser Leu 
1               5                   10                  15      


Tyr Arg Gln Tyr Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu Glu 
            20                  25                  30          


Asp Glu Val Trp Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr Ser 
        35                  40                  45              


Lys His Gln Glu Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala Val 
    50                  55                  60                  


Gly Leu Ser Glu Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala Asp 
65                  70                  75                  80  


Gln Ala Ser Ile Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu Gln 
                85                  90                  95      


Val Glu Glu Val His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu Ala 
            100                 105                 110         


Glu Ala Gln Ile Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly Glu 
        115                 120                 125             


Glu Arg Ala Glu Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp 
    130                 135                 140         


<210>  158
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Arg Arg Ala Val Ser Leu Val Thr Asp Ser Thr Ser Thr Phe Leu 
1               5                   10                  15      


Ser Gln Thr Thr Tyr Ala Leu Ile Glu Ala Ile Thr Glu Tyr Thr Lys 
            20                  25                  30          


Ala Val Tyr Thr Leu Thr Ser Leu Tyr Arg Gln Tyr Thr Ser Leu Leu 
        35                  40                  45              


Gly Lys Met Asn Ser Glu Glu Glu Asp Glu Val Trp Gln Val Ile Ile 
    50                  55                  60                  


Gly Ala Arg Ala Glu Met Thr Ser Lys His Gln Glu Tyr Leu Lys Leu 
65                  70                  75                  80  


Glu Thr Thr Trp Met Thr Ala Val Gly Leu Ser Glu Met Ala Ala Glu 
                85                  90                  95      


Ala Ala Tyr Gln Thr Gly Ala Asp Gln Ala Ser Ile Thr Ala Arg Asn 
            100                 105                 110         


His Ile Gln Leu Val Lys Leu Gln Val Glu Glu Val His Gln Leu Ser 
        115                 120                 125             


Arg Lys Ala Glu Thr Lys Leu Ala Glu Ala Gln Ile Glu Glu Leu Arg 
    130                 135                 140                 


Gln Lys Thr Gln Glu Glu Gly Glu Glu Arg Ala Glu Ser Glu Gln Glu 
145                 150                 155                 160 


Ala Tyr Leu Arg Glu Asp 
                165     


<210>  159
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Lys Ser Asp Phe Tyr Phe Gln Lys Ser Glu Pro His Ser Leu Ser 
1               5                   10                  15      


Ser Glu Ala Leu Met Arg Arg Ala Val Ser Leu Val Thr Asp Ser Thr 
            20                  25                  30          


Ser Thr Phe Leu Ser Gln Thr Thr Tyr Ala Leu Ile Glu Ala Ile Thr 
        35                  40                  45              


Glu Tyr Thr Lys Ala Val Tyr Thr Leu Thr Ser Leu Tyr Arg Gln Tyr 
    50                  55                  60                  


Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu Glu Asp Glu Val Trp 
65                  70                  75                  80  


Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr Ser Lys His Gln Glu 
                85                  90                  95      


Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala Val Gly Leu Ser Glu 
            100                 105                 110         


Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala Asp Gln Ala Ser Ile 
        115                 120                 125             


Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu Gln Val Glu Glu Val 
    130                 135                 140                 


His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu Ala Glu Ala Gln Ile 
145                 150                 155                 160 


Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly Glu Glu Arg Ala Glu 
                165                 170                 175     


Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp 
            180                 185     


<210>  160
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Ala Ala Leu Lys Ser Trp Leu Ser Arg Ser Val Thr Ser Phe Phe 
1               5                   10                  15      


Arg Tyr Arg Gln Cys Leu Cys Val Pro Val Val Ala Asn Phe Lys Lys 
            20                  25                  30          


Arg Cys Phe Ser Glu Leu Ile Arg Pro Trp His Lys Thr Val Thr Ile 
        35                  40                  45              


Gly Phe Gly Val Thr Leu Cys Ala Val Pro Ile Ala Gln Ala Val Tyr 
    50                  55                  60                  


Thr Leu Thr Ser Leu Tyr Arg Gln Tyr Thr Ser Leu Leu Gly Lys Met 
65                  70                  75                  80  


Asn Ser Glu Glu Glu Asp Glu Val Trp Gln Val Ile Ile Gly Ala Arg 
                85                  90                  95      


Ala Glu Met Thr Ser Lys His Gln Glu Tyr Leu Lys Leu Glu Thr Thr 
            100                 105                 110         


Trp Met Thr Ala Val Gly Leu Ser Glu Met Ala Ala Glu Ala Ala Tyr 
        115                 120                 125             


Gln Thr Gly Ala Asp Gln Ala Ser Ile Thr Ala Arg Asn His Ile Gln 
    130                 135                 140                 


Leu Val Lys Leu Gln Val Glu Glu Val His Gln Leu Ser Arg Lys Ala 
145                 150                 155                 160 


Glu Thr Lys Leu Ala Glu Ala Gln Ile Glu Glu Leu Arg Gln Lys Thr 
                165                 170                 175     


Gln Glu Glu Gly Glu Glu Arg Ala Glu Ser Glu Gln Glu Ala Tyr Leu 
            180                 185                 190         


Arg Glu Asp 
        195 


<210>  161
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Ala Ala Leu Lys Ser Trp Leu Ser Arg Ser Val Thr Ser Phe Phe 
1               5                   10                  15      


Arg Tyr Arg Gln Cys Leu Cys Val Pro Val Val Ala Asn Phe Lys Lys 
            20                  25                  30          


Arg Cys Phe Ser Glu Leu Ile Arg Pro Trp His Lys Thr Val Thr Ile 
        35                  40                  45              


Gly Phe Gly Val Thr Leu Cys Ala Val Pro Ile Ala Gln Lys Ser Glu 
    50                  55                  60                  


Pro His Ser Leu Ser Ser Glu Ala Leu Met Arg Arg Ala Val Ser Leu 
65                  70                  75                  80  


Val Thr Asp Ser Thr Ser Thr Phe Leu Ser Gln Thr Thr Tyr Ala Leu 
                85                  90                  95      


Ile Glu Ala Ile Thr Glu Tyr Thr Lys Ala Val Tyr Thr Leu Thr Ser 
            100                 105                 110         


Leu Tyr Arg Gln Tyr Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu 
        115                 120                 125             


Glu Asp Glu Val Trp Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr 
    130                 135                 140                 


Ser Lys His Gln Glu Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala 
145                 150                 155                 160 


Val Gly Leu Ser Glu Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala 
                165                 170                 175     


Asp Gln Ala Ser Ile Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu 
            180                 185                 190         


Gln Val Glu Glu Val His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu 
        195                 200                 205             


Ala Glu Ala Gln Ile Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly 
    210                 215                 220                 


Glu Glu Arg Ala Glu Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp 
225                 230                 235                 


<210>  162
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Lys Ser Asp Phe Tyr Phe Gln Lys Ser Glu Pro His Ser Leu Ser 
1               5                   10                  15      


Ser Glu Ala Leu Met Arg Arg Ala Val Ser Leu Val Thr Asp Ser Thr 
            20                  25                  30          


Ser Thr Phe Leu Ser Gln Thr Thr Tyr Ala Leu Ile Glu Ala Ile Thr 
        35                  40                  45              


Glu Tyr Thr Lys Ala Val Tyr Thr Leu Thr Ser Leu Tyr Arg Gln Tyr 
    50                  55                  60                  


Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu Glu Asp Glu Val Trp 
65                  70                  75                  80  


Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr Ser Lys His Gln Glu 
                85                  90                  95      


Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala Val Gly Leu Ser Glu 
            100                 105                 110         


Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala Asp Gln Ala Ser Ile 
        115                 120                 125             


Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu Gln Val Glu Glu Val 
    130                 135                 140                 


His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu Ala Glu Ala Gln Ile 
145                 150                 155                 160 


Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly Glu Glu Arg Ala Glu 
                165                 170                 175     


Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp 
            180                 185     


<210>  163
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Met Ala Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala Met 
1               5                   10                  15      


Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr 
            20                  25                  30          


Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro 
        35                  40                  45              


Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro 
    50                  55                  60                  


Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr 
65                  70                  75                  80  


Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr 
                85                  90                  95      


Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu 
            100                 105                 110         


Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys 
        115                 120                 125             


Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn 
    130                 135                 140                 


His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn 
145                 150                 155                 160 


Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser 
                165                 170                 175     


Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
            180                 185                 190         


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
        195                 200                 205             


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
    210                 215                 220                 


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
225                 230                 235                 240 


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
                245                 250                 255     


Ser Ser Arg Leu His Thr Cys Gln Arg His 
            260                 265     


<210>  164
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 
1               5                   10                  15      


Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 
            20                  25                  30          


Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 
        35                  40                  45              


Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 
65                  70                  75                  80  


Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 
                85                  90                  95      


Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 
            100                 105                 110         


Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 
        115                 120                 125             


Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala 
    130                 135                 140                 


Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala 
                165                 170                 175     


Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg 
            180                 185                 190         


Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala 
        195                 200                 205             


Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu Val Cys Arg Ala Gly Cys 
    210                 215                 220                 


Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu 
225                 230                 235                 240 


Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser 
                245                 250                 255     


Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val 
            260                 265                 270         


Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser 
        275                 280                 285             


Cys Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe 
    290                 295                 300                 


Tyr Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro 
305                 310                 315                 320 


Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala 
                325                 330                 335     


Tyr Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys 
            340                 345                 350         


Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys 
        355                 360                 365             


Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala 
    370                 375                 380                 


Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys 
385                 390                 395                 400 


Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser 
                405                 410                 415     


Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro 
            420                 425                 430         


Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe 
        435                 440                 445             


Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Ala Arg Cys 
    450                 455                 460                 


Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro 
465                 470                 475                 480 


Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu Leu Pro Pro Ala 
                485                 490                 495     


Leu Gly Leu Leu Val Ala Ala Gly Val Ala Gly Ala Ala Leu Leu Leu 
            500                 505                 510         


Val His Val Arg Arg Arg Gly His Ser Gln Asp Ala Gly Ser Arg Leu 
        515                 520                 525             


Leu Ala Gly Thr Pro Glu Pro Ser Val His Ala Leu Pro Asp Ala Leu 
    530                 535                 540                 


Asn Asn Leu Arg Thr Gln Glu Gly Ser Gly Asp Gly Pro Ser Ser Ser 
545                 550                 555                 560 


Val Asp Trp Asn Arg Pro Glu Asp Val Asp Pro Gln Gly Ile Tyr Val 
                565                 570                 575     


Ile Ser Ala Pro Ser Ile Tyr Ala Arg Glu Val Ala Thr Pro Leu Phe 
            580                 585                 590         


Pro Pro Leu His Thr Gly Arg Ala Gly Gln Arg Gln His Leu Leu Phe 
        595                 600                 605             


Pro Tyr Pro Ser Ser Ile Leu Ser Val Lys 
    610                 615             


<210>  165
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 
1               5                   10                  15      


Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 
            20                  25                  30          


Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 
        35                  40                  45              


Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 
65                  70                  75                  80  


Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 
                85                  90                  95      


Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 
            100                 105                 110         


Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 
        115                 120                 125             


Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala 
    130                 135                 140                 


Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala 
                165                 170                 175     


Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg 
            180                 185                 190         


Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala 
        195                 200                 205             


Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu Val Cys Arg Ala Gly Cys 
    210                 215                 220                 


Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu 
225                 230                 235                 240 


Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser 
                245                 250                 255     


Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val 
            260                 265                 270         


Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser 
        275                 280                 285             


Cys Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe 
    290                 295                 300                 


Tyr Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro 
305                 310                 315                 320 


Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala 
                325                 330                 335     


Tyr Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys 
            340                 345                 350         


Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys 
        355                 360                 365             


Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala 
    370                 375                 380                 


Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys 
385                 390                 395                 400 


Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser 
                405                 410                 415     


Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro 
            420                 425                 430         


Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe 
        435                 440                 445             


Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Ala Arg Cys 
    450                 455                 460                 


Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro 
465                 470                 475                 480 


Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu Leu Pro Pro Ala 
                485                 490                 495     


Leu Gly Leu Leu Val Ala Ala Gly Val Ala Gly Ala Ala Leu Leu Leu 
            500                 505                 510         


Val His Val Arg Arg Arg Gly His Ser Gln Asp Ala Gly Ser Arg Leu 
        515                 520                 525             


Leu Ala Gly Thr Pro Glu Pro Ser Val His Ala Leu Pro Asp Ala Leu 
    530                 535                 540                 


Asn Asn Leu Arg Thr Gln Glu Gly Ser Gly Asp Gly Pro Ser Ser Ser 
545                 550                 555                 560 


Val Asp Trp Asn Arg Pro Glu Asp Val Asp Pro Gln Gly Ile Tyr Val 
                565                 570                 575     


Ile Ser Ala Pro Ser Ile Tyr Ala Arg Glu Ala 
            580                 585         


<210>  166
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu 
            20                  25                  30          


Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg 
        35                  40                  45              


Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His 
    50                  55                  60                  


Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser 
65                  70                  75                  80  


Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser 
                85                  90                  95      


Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro 
            100                 105                 110         


Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp 
        115                 120                 125             


Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala 
    130                 135                 140                 


Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln 
145                 150                 155                 160 


Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser 
                165                 170                 175     


Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn 
            180                 185                 190         


Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys 
        195                 200                 205             


Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser 
    210                 215                 220                 


Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu 
225                 230                 235                 240 


Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His 
                245                 250                 255     


Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys 
            260                 265                 270         


Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys 
        275                 280                 285             


Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly 
    290                 295                 300                 


Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp 
305                 310                 315                 320 


Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys Arg Asn Gly 
                325                 330                 335     


Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu Cys Pro Pro 
            340                 345                 350         


Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser Cys Ala Asp 
        355                 360                 365             


Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly Ala 
    370                 375                 380                 


Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys Glu 
385                 390                 395                 400 


Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly Gln 
                405                 410                 415     


Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg Pro Gly Phe 
            420                 425                 430         


Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala Arg Asn Pro 
        435                 440                 445             


Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Leu Met Cys 
    450                 455                 460                 


Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Thr Ser 
465                 470                 475                 480 


Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala Thr Cys Tyr 
                485                 490                 495     


Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro Tyr Gly Phe 
            500                 505                 510         


Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser Phe Pro 
        515                 520                 525             


Trp Val Ala Val Ser Leu Gly Val Gly Leu Ala Val Leu Leu Val Leu 
    530                 535                 540                 


Leu Gly Met Val Ala Val Ala Val Arg Gln Leu Arg Leu Arg Arg Pro 
545                 550                 555                 560 


Asp Asp Gly Ser Arg Glu Ala Met Asn Asn Leu Ser Asp Phe Gln Lys 
                565                 570                 575     


Asp Asn Leu Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn Gln Lys Lys 
            580                 585                 590         


Glu Leu Glu Val Asp Cys Gly Leu Asp Lys Ser Asn Cys Gly Lys Gln 
        595                 600                 605             


Gln Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro Leu Gly Arg 
    610                 615                 620                 


Gly Thr Met Pro Gly Lys Phe Pro His Ser Asp Lys Ser Leu Gly Glu 
625                 630                 635                 640 


Lys Ala Pro Leu Arg Leu His Ser Glu Lys Pro Glu Cys Arg Ile Ser 
                645                 650                 655     


Ala Ile Cys Ser Pro Arg Asp Ser Met Tyr Gln Ser Val Cys Leu Ile 
            660                 665                 670         


Ser Glu Glu Arg Asn Glu Cys Val Ile Ala Thr Glu Val 
        675                 680                 685 


<210>  167
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  168
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Ser 
625             


<210>  169
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Leu Ser 
                405 


<210>  170
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Pro Gly Asn Glu Ser Leu Lys Ala Met Leu Phe Cys Leu 
625                 630                 635                 640 


Phe Lys Leu Ser Ser Cys Asn Gln Ser Asn Asp Gly Ser Val Ser His 
                645                 650                 655     


Gln Ser Gly Ser Pro Ala Ala Gln Glu Ser Cys Leu Gly Trp Ile Pro 
            660                 665                 670         


Ser Leu Leu Pro Ser Glu Phe Gln Leu Gly Trp Gly Gly Cys Ser His 
        675                 680                 685             


Leu His Ala Trp Pro Ser Ala Ser Val Ile Ile Thr Ala Ser Ser Cys 
    690                 695                 700                 


His 
705 


<210>  171
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Asn Phe Ala Glu Arg Glu Gly Ser Lys Arg Tyr Cys Ile Gln Thr 
1               5                   10                  15      


Lys His Val Ala Ile Leu Cys Ala Val Val Val Gly Val Gly Leu Ile 
            20                  25                  30          


Val Gly Leu Ala Val Gly Leu Thr Arg Ser Cys Asp Ser Ser Gly Asp 
        35                  40                  45              


Gly Gly Pro Gly Thr Ala Pro Ala Pro Ser His Leu Pro Ser Ser Thr 
    50                  55                  60                  


Ala Ser Pro Ser Gly Pro Pro Ala Gln Asp Gln Asp Ile Cys Pro Ala 
65                  70                  75                  80  


Ser Glu Asp Glu Ser Gly Gln Trp Lys Asn Phe Arg Leu Pro Asp Phe 
                85                  90                  95      


Val Asn Pro Val His Tyr Asp Leu His Val Lys Pro Leu Leu Glu Glu 
            100                 105                 110         


Asp Thr Tyr Thr Gly Thr Val Ser Ile Ser Ile Asn Leu Ser Ala Pro 
        115                 120                 125             


Thr Arg Tyr Leu Trp Leu His Leu Arg Glu Thr Arg Ile Thr Arg Leu 
    130                 135                 140                 


Pro Glu Leu Lys Arg Pro Ser Gly Asp Gln Val Gln Val Arg Arg Cys 
145                 150                 155                 160 


Phe Glu Tyr Lys Lys Gln Glu Tyr Val Val Val Glu Ala Glu Glu Glu 
                165                 170                 175     


Leu Thr Pro Ser Ser Gly Asp Gly Leu Tyr Leu Leu Thr Met Glu Phe 
            180                 185                 190         


Ala Gly Trp Leu Asn Gly Ser Leu Val Gly Phe Tyr Arg Thr Thr Tyr 
        195                 200                 205             


Thr Glu Asn Gly Gln Val Lys Ser Ile Val Ala Thr Asp His Glu Pro 
    210                 215                 220                 


Thr Asp Ala Arg Lys Ser Phe Pro Cys Phe Asp Glu Pro Asn Lys Lys 
225                 230                 235                 240 


Ala Thr Tyr Thr Ile Ser Ile Thr His Pro Lys Glu Tyr Gly Ala Leu 
                245                 250                 255     


Ser Asn Met Pro Val Ala Lys Glu Glu Ser Val Asp Asp Lys Trp Thr 
            260                 265                 270         


Arg Thr Thr Phe Glu Lys Ser Val Pro Met Ser Thr Tyr Leu Val Cys 
        275                 280                 285             


Phe Ala Val His Gln Phe Asp Ser Val Lys Arg Ile Ser Asn Ser Gly 
    290                 295                 300                 


Lys Pro Leu Thr Ile Tyr Val Gln Pro Glu Gln Lys His Thr Ala Glu 
305                 310                 315                 320 


Tyr Ala Ala Asn Ile Thr Lys Ser Val Phe Asp Tyr Phe Glu Glu Tyr 
                325                 330                 335     


Phe Ala Met Asn Tyr Ser Leu Pro Lys Leu Asp Lys Ile Ala Ile Pro 
            340                 345                 350         


Asp Phe Gly Thr Gly Ala Met Glu Asn Trp Gly Leu Ile Thr Tyr Arg 
        355                 360                 365             


Glu Thr Asn Leu Leu Tyr Asp Pro Lys Glu Ser Ala Ser Ser Asn Gln 
    370                 375                 380                 


Gln Arg Val Ala Thr Val Val Ala His Glu Leu Val His Gln Trp Phe 
385                 390                 395                 400 


Gly Asn Ile Val Thr Met Asp Trp Trp Glu Asp Leu Trp Leu Asn Glu 
                405                 410                 415     


Gly Phe Ala Ser Phe Phe Glu Phe Leu Gly Val Asn His Ala Glu Thr 
            420                 425                 430         


Asp Trp Gln Met Arg Asp Gln Met Leu Leu Glu Asp Val Leu Pro Val 
        435                 440                 445             


Gln Glu Asp Asp Ser Leu Met Ser Ser His Pro Ile Ile Val Thr Val 
    450                 455                 460                 


Thr Thr Pro Asp Glu Ile Thr Ser Val Phe Asp Gly Ile Ser Tyr Ser 
465                 470                 475                 480 


Lys Gly Ser Ser Ile Leu Arg Met Leu Glu Asp Trp Ile Lys Pro Glu 
                485                 490                 495     


Asn Phe Gln Lys Gly Cys Gln Met Tyr Leu Glu Lys Tyr Gln Phe Lys 
            500                 505                 510         


Asn Ala Lys Thr Ser Asp Phe Trp Ala Ala Leu Glu Glu Ala Ser Arg 
        515                 520                 525             


Leu Pro Val Lys Glu Val Met Asp Thr Trp Thr Arg Gln Met Gly Tyr 
    530                 535                 540                 


Pro Val Leu Asn Val Asn Gly Val Lys Asn Ile Thr Gln Lys Arg Phe 
545                 550                 555                 560 


Leu Leu Asp Pro Arg Ala Asn Pro Ser Gln Pro Pro Ser Asp Leu Gly 
                565                 570                 575     


Tyr Thr Trp Asn Ile Pro Val Lys Trp Thr Glu Asp Asn Ile Thr Ser 
            580                 585                 590         


Ser Val Leu Phe Asn Arg Ser Glu Lys Glu Gly Ile Thr Leu Asn Ser 
        595                 600                 605             


Ser Asn Pro Ser Gly Asn Ala Phe Leu Lys Ile Asn Pro Asp His Ile 
    610                 615                 620                 


Gly Phe Tyr Arg Val Asn Tyr Glu Val Ala Thr Trp Asp Ser Ile Ala 
625                 630                 635                 640 


Thr Ala Leu Ser Leu Asn His Lys Thr Phe Ser Ser Ala Asp Arg Ala 
                645                 650                 655     


Ser Leu Ile Asp Asp Ala Phe Ala Leu Ala Arg Ala Gln Leu Leu Asp 
            660                 665                 670         


Tyr Lys Val Ala Leu Asn Leu Thr Lys Tyr Leu Lys Arg Glu Glu Asn 
        675                 680                 685             


Phe Leu Pro Trp Gln Arg Val Ile Ser Ala Val Thr Tyr Ile Ile Ser 
    690                 695                 700                 


Met Phe Glu Asp Asp Lys Glu Leu Tyr Pro Met Ile Glu Glu Tyr Phe 
705                 710                 715                 720 


Gln Gly Gln Val Lys Pro Ile Ala Asp Ser Leu Gly Trp Asn Asp Ala 
                725                 730                 735     


Gly Asp His Val Thr Lys Leu Leu Arg Ser Ser Val Leu Gly Phe Ala 
            740                 745                 750         


Cys Lys Met Gly Asp Arg Glu Ala Leu Asn Asn Ala Ser Ser Leu Phe 
        755                 760                 765             


Glu Gln Trp Leu Asn Gly Thr Val Ser Leu Pro Val Asn Leu Arg Leu 
    770                 775                 780                 


Leu Val Tyr Arg Tyr Gly Met Gln Asn Ser Gly Asn Glu Ile Ser Trp 
785                 790                 795                 800 


Asn Tyr Thr Leu Glu Gln Tyr Gln Lys Thr Ser Leu Ala Gln Glu Lys 
                805                 810                 815     


Glu Lys Leu Leu Tyr Gly Leu Ala Ser Val Lys Asn Val Thr Leu Leu 
            820                 825                 830         


Ser Arg Tyr Leu Asp Leu Leu Lys Asp Thr Asn Leu Ile Lys Thr Gln 
        835                 840                 845             


Asp Val Phe Thr Val Ile Arg Tyr Ile Ser Tyr Asn Ser Tyr Gly Lys 
    850                 855                 860                 


Asn Met Ala Trp Asn Trp Ile Gln Leu Asn Trp Asp Tyr Leu Val Asn 
865                 870                 875                 880 


Arg Tyr Thr Leu Asn Asn Arg Asn Leu Gly Arg Ile Val Thr Ile Ala 
                885                 890                 895     


Glu Pro Phe Asn Thr Glu Leu Gln Leu Trp Gln Met Glu Ser Phe Phe 
            900                 905                 910         


Ala Lys Tyr Pro Gln Ala Gly Ala Gly Glu Lys Pro Arg Glu Gln Val 
        915                 920                 925             


Leu Glu Thr Val Lys Asn Asn Ile Glu Trp Leu Lys Gln His Arg Asn 
    930                 935                 940                 


Thr Ile Arg Glu Trp Phe Phe Asn Leu Leu Glu Ser Gly 
945                 950                 955         


<210>  172
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Glu Ser Thr Leu Thr Leu Ala Thr Glu Gln Pro Val Lys Lys Asn 
1               5                   10                  15      


Thr Leu Lys Lys Tyr Lys Ile Ala Cys Ile Val Leu Leu Ala Leu Leu 
            20                  25                  30          


Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys Leu 
        35                  40                  45              


Glu Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg 
    50                  55                  60                  


Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp 
65                  70                  75                  80  


Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp 
                85                  90                  95      


Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu Ala Ser Leu 
            100                 105                 110         


Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Ala Asp 
        115                 120                 125             


Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys 
    130                 135                 140                 


Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro 
145                 150                 155                 160 


Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr 
                165                 170                 175     


Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile 
            180                 185                 190         


His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn 
        195                 200                 205             


His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile 
    210                 215                 220                 


Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser 
225                 230                 235                 240 


Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp 
                245                 250                 255     


Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro 
            260                 265                 270         


Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro 
        275                 280                 285             


Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys 
    290                 295                 300                 


Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr 
305                 310                 315                 320 


Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala 
                325                 330                 335     


Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu 
            340                 345                 350         


Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile 
        355                 360                 365             


Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu 
    370                 375                 380                 


Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu 
385                 390                 395                 400 


Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe 
                405                 410                 415     


Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro 
            420                 425                 430         


Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
        435                 440                 445             


His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp 
    450                 455                 460                 


Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly 
465                 470                 475                 480 


Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe 
                485                 490                 495     


Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe 
            500                 505                 510         


Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln 
        515                 520                 525             


Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys 
    530                 535                 540                 


Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser 
545                 550                 555                 560 


Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe 
                565                 570                 575     


Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met 
            580                 585                 590         


Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu 
        595                 600                 605             


Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu 
    610                 615                 620                 


Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met 
625                 630                 635                 640 


Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro 
                645                 650                 655     


Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro 
            660                 665                 670         


Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile 
        675                 680                 685             


Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser 
    690                 695                 700                 


Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu 
705                 710                 715                 720 


Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His 
                725                 730                 735     


Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
            740                 745                 750         


Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His 
        755                 760                 765             


Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu 
    770                 775                 780                 


Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp 
785                 790                 795                 800 


Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu 
                805                 810                 815     


Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe 
            820                 825                 830         


Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu 
        835                 840                 845             


Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu 
    850                 855                 860                 


Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile 
865                 870                 875 


<210>  173
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  174
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys 
1               5                   10                  15      


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu 
            20                  25                  30          


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr 
        35                  40                  45              


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile 
    50                  55                  60                  


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp 
65                  70                  75                  80  


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile 
                85                  90                  95      


Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala 
            100                 105                 110         


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu 
        115                 120                 125             


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr 
    130                 135                 140                 


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His 
145                 150                 155                 160 


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys 
                165                 170                 175     


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu 
            180                 185                 190         


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu 
        195                 200                 205             


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala 
    210                 215                 220                 


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly 
225                 230                 235                 240 


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala 
            260                 265                 270         


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser 
        275                 280                 285             


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr 
                325                 330                 335     


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln 
            340                 345                 350         


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln 
        355                 360                 365             


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg 
    370                 375                 380                 


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser 
385                 390                 395                 400 


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn 
                405                 410                 415     


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val 
            420                 425                 430         


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser 
        435                 440                 445             


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser 
    450                 455                 460                 


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn 
465                 470                 475                 480 


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp 
                485                 490                 495     


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln 
            500                 505                 510         


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser 
        515                 520                 525             


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly 
    530                 535                 540                 


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg 
545                 550                 555                 560 


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe 
                565                 570                 575     


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His 
            580                 585                 590         


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile 
        595                 600                 605             


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe 
    610                 615                 620                 


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln 
                645                 650                 655     


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His 
            660                 665                 670         


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met 
        675                 680                 685             


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu 
    690                 695                 700                 


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu 
705                 710                 715                 720 


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val 
                725                 730                 735     


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val 
            740                 745                 750         


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro 
        755                 760                 765             


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr 
    770                 775                 780                 


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val 
785                 790                 795                 800 


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg 
                805                 810                 815     


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp 
            820                 825                 830         


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln 
        835                 840                 845             


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe 
    850                 855                 860                 


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser 
865                 870                 875                 880 


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro 
                885                 890                 895     


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp 
            900                 905                 910         


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala 
        915                 920                 925             


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile 
    930                 935                 940                 


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr 
945                 950                 955                 960 


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
                965                 970                 975     


<210>  175
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile 
1               5                   10                  15      


Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu 
            20                  25                  30          


Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn 
    50                  55                  60                  


Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn 
65                  70                  75                  80  


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln 
                85                  90                  95      


Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu 
            100                 105                 110         


Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr 
        115                 120                 125             


Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val 
    130                 135                 140                 


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu 
145                 150                 155                 160 


Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro 
                165                 170                 175     


Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys 
            180                 185                 190         


Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile 
        195                 200                 205             


Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe 
    210                 215                 220                 


Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp 
                245                 250                 255     


Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys 
            260                 265                 270         


Gly Asp Thr Cys Glu Pro Cys Gly Arg Gly Phe Tyr Lys Ser Ser Ser 
        275                 280                 285             


Gln Asp Leu Gln Cys Ser Arg Cys Pro Thr His Ser Phe Ser Asp Lys 
    290                 295                 300                 


Glu Gly Ser Ser Arg Cys Glu Cys Glu Asp Gly Tyr Tyr Arg Ala Pro 
305                 310                 315                 320 


Ser Asp Pro Pro Tyr Val Ala Cys Thr Arg Pro Pro Ser Ala Pro Gln 
                325                 330                 335     


Asn Leu Ile Phe Asn Ile Asn Gln Thr Thr Val Ser Leu Glu Trp Ser 
            340                 345                 350         


Pro Pro Ala Asp Asn Gly Gly Arg Asn Asp Val Thr Tyr Arg Ile Leu 
        355                 360                 365             


Cys Lys Arg Cys Ser Trp Glu Gln Gly Glu Cys Val Pro Cys Gly Ser 
    370                 375                 380                 


Asn Ile Gly Tyr Met Pro Gln Gln Thr Gly Leu Glu Asp Asn Tyr Val 
385                 390                 395                 400 


Thr Val Met Asp Leu Leu Ala His Ala Asn Tyr Thr Phe Glu Val Glu 
                405                 410                 415     


Ala Val Asn Gly Val Ser Asp Leu Ser Arg Ser Gln Arg Leu Phe Ala 
            420                 425                 430         


Ala Val Ser Ile Thr Thr Gly Gln Ala Ala Pro Ser Gln Val Ser Gly 
        435                 440                 445             


Val Met Lys Glu Arg Val Leu Gln Arg Ser Val Glu Leu Ser Trp Gln 
    450                 455                 460                 


Glu Pro Glu His Pro Asn Gly Val Ile Thr Glu Tyr Glu Ile Lys Tyr 
465                 470                 475                 480 


Tyr Glu Lys Asp Gln Arg Glu Arg Thr Tyr Ser Thr Val Lys Thr Lys 
                485                 490                 495     


Ser Thr Ser Ala Ser Ile Asn Asn Leu Lys Pro Gly Thr Val Tyr Val 
            500                 505                 510         


Phe Gln Ile Arg Ala Phe Thr Ala Ala Gly Tyr Gly Asn Tyr Ser Pro 
        515                 520                 525             


Arg Leu Asp Val Ala Thr Leu Glu Glu Ala Thr Ala Thr Ala Val Ser 
    530                 535                 540                 


Ser Glu Gln Asn Pro Val Ile Ile Ile Ala Val Val Ala Val Ala Gly 
545                 550                 555                 560 


Thr Ile Ile Leu Val Phe Met Val Phe Gly Phe Ile Ile Gly Arg Arg 
                565                 570                 575     


His Cys Gly Tyr Ser Lys Ala Asp Gln Glu Gly Asp Glu Glu Leu Tyr 
            580                 585                 590         


Phe His Phe Lys Phe Pro Gly Thr Lys Thr Tyr Ile Asp Pro Glu Thr 
        595                 600                 605             


Tyr Glu Asp Pro Asn Arg Ala Val His Gln Phe Ala Lys Glu Leu Asp 
    610                 615                 620                 


Ala Ser Cys Ile Lys Ile Glu Arg Val Ile Gly Ala Gly Glu Phe Gly 
625                 630                 635                 640 


Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly Lys Arg Asp Val Ala 
                645                 650                 655     


Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr Glu Lys Gln Arg Arg 
            660                 665                 670         


Asp Phe Leu Cys Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro Asn 
        675                 680                 685             


Val Val His Leu Glu Gly Val Val Thr Arg Gly Lys Pro Val Met Ile 
    690                 695                 700                 


Val Ile Glu Phe Met Glu Asn Gly Ala Leu Asp Ala Phe Leu Arg Lys 
705                 710                 715                 720 


His Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly 
                725                 730                 735     


Ile Ala Ala Gly Met Arg Tyr Leu Ala Asp Met Gly Tyr Val His Arg 
            740                 745                 750         


Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys 
        755                 760                 765             


Val Ser Asp Phe Gly Leu Ser Arg Val Ile Glu Asp Asp Pro Glu Ala 
    770                 775                 780                 


Val Tyr Thr Thr Thr Gly Gly Lys Ile Pro Val Arg Trp Thr Ala Pro 
785                 790                 795                 800 


Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser 
                805                 810                 815     


Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr 
            820                 825                 830         


Trp Asp Met Ser Asn Gln Asp Val Ile Lys Ala Ile Glu Glu Gly Tyr 
        835                 840                 845             


Arg Leu Pro Ala Pro Met Asp Cys Pro Ala Gly Leu His Gln Leu Met 
    850                 855                 860                 


Leu Asp Cys Trp Gln Lys Glu Arg Ala Glu Arg Pro Lys Phe Glu Gln 
865                 870                 875                 880 


Ile Val Gly Ile Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys 
                885                 890                 895     


Thr Pro Leu Gly Thr Cys Ser Arg Pro Ile Ser Pro Leu Leu Asp Gln 
            900                 905                 910         


Asn Thr Pro Asp Phe Thr Thr Phe Cys Ser Val Gly Glu Trp Leu Gln 
        915                 920                 925             


Ala Ile Lys Met Glu Arg Tyr Lys Asp Asn Phe Thr Ala Ala Gly Tyr 
    930                 935                 940                 


Asn Ser Leu Glu Ser Val Ala Arg Met Thr Ile Glu Asp Val Met Ser 
945                 950                 955                 960 


Leu Gly Ile Thr Leu Val Gly His Gln Lys Lys Ile Met Ser Ser Ile 
                965                 970                 975     


Gln Thr Met Arg Ala Gln Met Leu His Leu His Gly Thr Gly Ile Gln 
            980                 985                 990         


Val 
    


<210>  176
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile 
1               5                   10                  15      


Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu 
            20                  25                  30          


Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn 
    50                  55                  60                  


Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn 
65                  70                  75                  80  


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln 
                85                  90                  95      


Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu 
            100                 105                 110         


Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr 
        115                 120                 125             


Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val 
    130                 135                 140                 


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu 
145                 150                 155                 160 


Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro 
                165                 170                 175     


Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys 
            180                 185                 190         


Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile 
        195                 200                 205             


Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe 
    210                 215                 220                 


Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp 
                245                 250                 255     


Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys 
            260                 265                 270         


Gly Asp Thr Cys Glu Arg Lys 
        275                 


<210>  177
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile 
1               5                   10                  15      


Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu 
            20                  25                  30          


Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn 
    50                  55                  60                  


Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn 
65                  70                  75                  80  


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln 
                85                  90                  95      


Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu 
            100                 105                 110         


Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr 
        115                 120                 125             


Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val 
    130                 135                 140                 


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu 
145                 150                 155                 160 


Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro 
                165                 170                 175     


Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys 
            180                 185                 190         


Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile 
        195                 200                 205             


Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe 
    210                 215                 220                 


Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp 
                245                 250                 255     


Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys 
            260                 265                 270         


Gly Asp Thr Cys Glu Pro Cys Gly Arg Gly Phe Tyr Lys Ser Ser Ser 
        275                 280                 285             


Gln Asp Leu Gln Cys Ser Arg Cys Pro Thr His Ser Phe Ser Asp Lys 
    290                 295                 300                 


Glu Gly Ser Ser Arg Cys Glu Cys Glu Asp Gly Tyr Tyr Arg Ala Pro 
305                 310                 315                 320 


Ser Asp Pro Pro Tyr Val Ala Cys Thr Arg Pro Pro Ser Ala Pro Gln 
                325                 330                 335     


Asn Leu Ile Phe Asn Ile Asn Gln Thr Thr Val Ser Leu Glu Trp Ser 
            340                 345                 350         


Pro Pro Ala Asp Asn Gly Gly Arg Asn Asp Val Thr Tyr Arg Ile Leu 
        355                 360                 365             


Cys Lys Arg Cys Ser Trp Glu Gln Gly Glu Cys Val Pro Cys Gly Ser 
    370                 375                 380                 


Asn Ile Gly Tyr Met Pro Gln Gln Thr Gly Leu Glu Asp Asn Tyr Val 
385                 390                 395                 400 


Thr Val Met Asp Leu Leu Ala His Ala Asn Tyr Thr Phe Glu Val Glu 
                405                 410                 415     


Ala Val Asn Gly Val Ser Asp Leu Ser Arg Ser Gln Arg Leu Phe Ala 
            420                 425                 430         


Ala Val Ser Ile Thr Thr Gly Gln Ala Ala Pro Ser Gln Val Ser Gly 
        435                 440                 445             


Val Met Lys Glu Arg Val Leu Gln Arg Ser Val Glu Leu Ser Trp Gln 
    450                 455                 460                 


Glu Pro Glu His Pro Asn Gly Val Ile Thr Glu Tyr Glu Ile Lys Tyr 
465                 470                 475                 480 


Tyr Glu Lys Asp Gln Arg Glu Arg Thr Tyr Ser Thr Val Lys Thr Lys 
                485                 490                 495     


Ser Thr Ser Ala Ser Ile Asn Asn Leu Lys Pro Gly Thr Val Tyr Val 
            500                 505                 510         


Phe Gln Ile Arg Ala Phe Thr Ala Ala Gly Tyr Gly Asn Tyr Ser Pro 
        515                 520                 525             


Arg Leu Asp Val Ala Thr Leu Glu Glu Ala Thr Gly Lys Met Phe Glu 
    530                 535                 540                 


Ala Thr Ala Val Ser Ser Glu Gln Asn Pro Val Ile Ile Ile Ala Val 
545                 550                 555                 560 


Val Ala Val Ala Gly Thr Ile Ile Leu Val Phe Met Val Phe Gly Phe 
                565                 570                 575     


Ile Ile Gly Arg Arg His Cys Gly Tyr Ser Lys Ala Asp Gln Glu Gly 
            580                 585                 590         


Asp Glu Glu Leu Tyr Phe His Phe Lys Phe Pro Gly Thr Lys Thr Tyr 
        595                 600                 605             


Ile Asp Pro Glu Thr Tyr Glu Asp Pro Asn Arg Ala Val His Gln Phe 
    610                 615                 620                 


Ala Lys Glu Leu Asp Ala Ser Cys Ile Lys Ile Glu Arg Val Ile Gly 
625                 630                 635                 640 


Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly 
                645                 650                 655     


Lys Arg Asp Val Ala Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr 
            660                 665                 670         


Glu Lys Gln Arg Arg Asp Phe Leu Cys Glu Ala Ser Ile Met Gly Gln 
        675                 680                 685             


Phe Asp His Pro Asn Val Val His Leu Glu Gly Val Val Thr Arg Gly 
    690                 695                 700                 


Lys Pro Val Met Ile Val Ile Glu Phe Met Glu Asn Gly Ala Leu Asp 
705                 710                 715                 720 


Ala Phe Leu Arg Lys His Asp Gly Gln Phe Thr Val Ile Gln Leu Val 
                725                 730                 735     


Gly Met Leu Arg Gly Ile Ala Ala Gly Met Arg Tyr Leu Ala Asp Met 
            740                 745                 750         


Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser 
        755                 760                 765             


Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Ile Glu 
    770                 775                 780                 


Asp Asp Pro Glu Ala Val Tyr Thr Thr Thr Gly Gly Lys Ile Pro Val 
785                 790                 795                 800 


Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala 
                805                 810                 815     


Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr 
            820                 825                 830         


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Lys Ala 
        835                 840                 845             


Ile Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Asp Cys Pro Ala Gly 
    850                 855                 860                 


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu Arg Ala Glu Arg 
865                 870                 875                 880 


Pro Lys Phe Glu Gln Ile Val Gly Ile Leu Asp Lys Met Ile Arg Asn 
                885                 890                 895     


Pro Asn Ser Leu Lys Thr Pro Leu Gly Thr Cys Ser Arg Pro Ile Ser 
            900                 905                 910         


Pro Leu Leu Asp Gln Asn Thr Pro Asp Phe Thr Thr Phe Cys Ser Val 
        915                 920                 925             


Gly Glu Trp Leu Gln Ala Ile Lys Met Glu Arg Tyr Lys Asp Asn Phe 
    930                 935                 940                 


Thr Ala Ala Gly Tyr Asn Ser Leu Glu Ser Val Ala Arg Met Thr Ile 
945                 950                 955                 960 


Glu Asp Val Met Ser Leu Gly Ile Thr Leu Val Gly His Gln Lys Lys 
                965                 970                 975     


Ile Met Ser Ser Ile Gln Thr Met Arg Ala Gln Met Leu His Leu His 
            980                 985                 990         


Gly Thr Gly Ile Gln Val 
        995             


<210>  178
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala 
1               5                   10                  15      


Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu 
            20                  25                  30          


Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr 
        35                  40                  45              


Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe 
    50                  55                  60                  


Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg 
65                  70                  75                  80  


Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys 
                85                  90                  95      


Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu 
            100                 105                 110         


Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe 
        115                 120                 125             


Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu 
    130                 135                 140                 


Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu Met Lys Val Asn Thr 
145                 150                 155                 160 


Glu Val Arg Ser Phe Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala 
                165                 170                 175     


Phe Gln Asp Tyr Gly Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe 
            180                 185                 190         


Phe Lys Lys Cys Pro Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu 
        195                 200                 205             


Thr Met Thr Gly Ala Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr 
    210                 215                 220                 


Cys Ile Pro Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys 
225                 230                 235                 240 


Asn Gly Asp Gly Glu Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys 
                245                 250                 255     


Pro Gly Tyr Glu Pro Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala 
            260                 265                 270         


Gly Thr Phe Lys Ala Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro 
        275                 280                 285             


Ser Asn Ser Arg Ser Pro Ala Glu Ala Ser Pro Ile Cys Thr Cys Arg 
    290                 295                 300                 


Thr Gly Tyr Tyr Arg Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr 
305                 310                 315                 320 


Ser Val Pro Ser Gly Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr 
                325                 330                 335     


Ser Ile Ile Leu Glu Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp 
            340                 345                 350         


Asp Val Thr Tyr Asn Ile Ile Cys Lys Lys Cys Arg Ala Asp Arg Arg 
        355                 360                 365             


Ser Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu 
    370                 375                 380                 


Gly Leu Thr Glu Cys Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr 
385                 390                 395                 400 


Pro Tyr Thr Phe Asp Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser 
                405                 410                 415     


Pro Phe Pro Pro Gln His Val Ser Val Asn Ile Thr Thr Asn Gln Ala 
            420                 425                 430         


Ala Pro Ser Thr Val Pro Ile Met His Gln Val Ser Ala Thr Met Arg 
        435                 440                 445             


Ser Ile Thr Leu Ser Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile 
    450                 455                 460                 


Leu Asp Tyr Glu Ile Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn 
465                 470                 475                 480 


Ser Ser Met Ala Arg Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu 
                485                 490                 495     


Arg Pro Gly Met Val Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala 
            500                 505                 510         


Gly Tyr Gly Lys Phe Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp 
        515                 520                 525             


Asp Asp Tyr Lys Ser Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly 
    530                 535                 540                 


Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu Val Ala Ile Ser 
545                 550                 555                 560 


Ile Val Cys Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser 
                565                 570                 575     


Asp Lys Leu Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys 
            580                 585                 590         


Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg 
        595                 600                 605             


Glu Phe Ala Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val 
    610                 615                 620                 


Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu 
625                 630                 635                 640 


Pro Gly Lys Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly 
                645                 650                 655     


Tyr Ser Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met 
            660                 665                 670         


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr 
        675                 680                 685             


Lys Ser Arg Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala 
    690                 695                 700                 


Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln 
705                 710                 715                 720 


Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala 
                725                 730                 735     


Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val 
            740                 745                 750         


Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr 
        755                 760                 765             


Leu Gln Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly 
    770                 775                 780                 


Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Ser Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys 
865                 870                 875                 880 


Met Ile Arg Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala 
                885                 890                 895     


Val Pro Ser Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala 
            900                 905                 910         


Phe Thr Thr Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr 
        915                 920                 925             


Arg Asp Ser Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr 
    930                 935                 940                 


Gln Met Thr Ser Glu Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly 
945                 950                 955                 960 


His Gln Lys Lys Ile Leu Asn Ser Ile His Ser Met Arg Val Gln Ile 
                965                 970                 975     


Ser Gln Ser Pro Thr Ala Met Ala 
            980                 


<210>  179
<211>  1225
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
        595                 600                 605             


Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 
    610                 615                 620                 


Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 
625                 630                 635                 640 


Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 
                645                 650                 655     


Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
            660                 665                 670         


Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
        675                 680                 685             


Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
    690                 695                 700                 


Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
705                 710                 715                 720 


Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
                725                 730                 735     


Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
            740                 745                 750         


Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
        755                 760                 765             


Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 
    770                 775                 780                 


Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 
785                 790                 795                 800 


Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
                805                 810                 815     


Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
            820                 825                 830         


Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
        835                 840                 845             


Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
    850                 855                 860                 


Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
865                 870                 875                 880 


Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
                885                 890                 895     


Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
            900                 905                 910         


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
        915                 920                 925             


Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
    930                 935                 940                 


Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
945                 950                 955                 960 


Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 
                965                 970                 975     


Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
            980                 985                 990         


Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
        995                 1000                 1005             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1010                 1015                 1020             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1025                 1030                 1035             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1040                 1045                 1050             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1055                 1060                 1065             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1070                 1075                 1080             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1085                 1090                 1095             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1100                 1105                 1110             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1115                 1120                 1125             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1145                 1150                 1155             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1160                 1165                 1170             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1175                 1180                 1185             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1190                 1195                 1200             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1205                 1210                 1215             


Leu Gly  Leu Asp Val Pro Val  
    1220                 1225 


<210>  180
<211>  1240
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Pro Arg Gly Ser Trp Lys Pro Gln Val Cys Thr Gly Thr Asp Met 
1               5                   10                  15      


Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg 
            20                  25                  30          


His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr 
        35                  40                  45              


Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu 
    50                  55                  60                  


Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro 
65                  70                  75                  80  


Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn 
                85                  90                  95      


Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr 
            100                 105                 110         


Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg 
        115                 120                 125             


Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro 
    130                 135                 140                 


Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys 
145                 150                 155                 160 


Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala 
                165                 170                 175     


Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu 
            180                 185                 190         


Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly 
        195                 200                 205             


Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln 
    210                 215                 220                 


Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys 
225                 230                 235                 240 


Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu 
                245                 250                 255     


Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly 
            260                 265                 270         


Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr 
        275                 280                 285             


Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn 
    290                 295                 300                 


Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser 
305                 310                 315                 320 


Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg 
                325                 330                 335     


Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys 
            340                 345                 350         


Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly 
        355                 360                 365             


Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val 
    370                 375                 380                 


Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp 
385                 390                 395                 400 


Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile 
                405                 410                 415     


Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly 
            420                 425                 430         


Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser 
        435                 440                 445             


Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr 
    450                 455                 460                 


Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His 
465                 470                 475                 480 


Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys 
                485                 490                 495     


His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln 
            500                 505                 510         


Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu 
        515                 520                 525             


Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His 
    530                 535                 540                 


Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr 
545                 550                 555                 560 


Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys 
                565                 570                 575     


Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp 
            580                 585                 590         


Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys 
        595                 600                 605             


Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp 
    610                 615                 620                 


Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile 
625                 630                 635                 640 


Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe 
                645                 650                 655     


Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665                 670         


Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser 
        675                 680                 685             


Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu 
    690                 695                 700                 


Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
705                 710                 715                 720 


Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala 
                725                 730                 735     


Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile 
            740                 745                 750         


Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser 
        755                 760                 765             


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln 
    770                 775                 780                 


Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly 
785                 790                 795                 800 


Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys 
                805                 810                 815     


Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala 
            820                 825                 830         


Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp 
        835                 840                 845             


Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala 
    850                 855                 860                 


Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
865                 870                 875                 880 


Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
                885                 890                 895     


Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro 
            900                 905                 910         


Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln 
        915                 920                 925             


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
    930                 935                 940                 


Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu 
945                 950                 955                 960 


Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn 
                965                 970                 975     


Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser 
            980                 985                 990         


Leu Leu Glu Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
        995                 1000                 1005             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1010                 1015                 1020             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1025                 1030                 1035             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1040                 1045                 1050             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1055                 1060                 1065             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1070                 1075                 1080             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1085                 1090                 1095             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1100                 1105                 1110             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1115                 1120                 1125             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1130                 1135                 1140             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1145                 1150                 1155             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1160                 1165                 1170             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1175                 1180                 1185             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1190                 1195                 1200             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1205                 1210                 1215             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1220                 1225                 1230             


Leu Gly  Leu Asp Val Pro Val  
    1235                 1240 


<210>  181
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser 
        595                 600             


<210>  182
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  183
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Gly Gln Phe Pro 
    130                 135                 140                 


Met Val Pro Ser Gly Leu Thr Pro Gln Pro Ala Gln Asp Trp Tyr Leu 
145                 150                 155                 160 


Leu Asp Asp Asp Pro Arg Leu Leu Thr Leu Ser Ala Ser Ser Lys Val 
                165                 170                 175     


Pro Val Thr Leu Ala Ala Val 
            180             


<210>  184
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  185
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Ala Ile Val Val Phe Ile Leu Lys Met Lys Val Lys Lys Pro Ala 
1               5                   10                  15      


Val Val Tyr Met Leu His Leu Ala Thr Ala Asp Val Leu Phe Val Ser 
            20                  25                  30          


Val Leu Pro Phe Lys Ile Ser Tyr Tyr Phe Ser Gly Ser Asp Trp Gln 
        35                  40                  45              


Phe Gly Ser Glu Leu Cys Arg Phe Val Thr Ala Ala Phe Tyr Cys Asn 
    50                  55                  60                  


Met Tyr Ala Ser Ile Leu Leu Met Thr Val Ile Ser Ile Asp Arg Phe 
65                  70                  75                  80  


Leu Ala Val Val Tyr Pro Met Gln Ser Leu Ser Trp Arg Thr Leu Gly 
                85                  90                  95      


Arg Ala Ser Phe Thr Cys Leu Ala Ile Trp Ala Leu Ala Ile Ala Gly 
            100                 105                 110         


Val Val Pro Leu Leu Leu Lys Glu Gln Thr Ile Gln Val Pro Gly Leu 
        115                 120                 125             


Asn Ile Thr Thr Cys His Asp Val Leu Asn Glu Thr Leu Leu Glu Gly 
    130                 135                 140                 


Tyr Tyr Ala Tyr Tyr Phe Ser Ala Phe Ser Ala Val Phe Phe Phe Val 
145                 150                 155                 160 


Pro Leu Ile Ile Ser Thr Val Cys Tyr Val Ser Ile Ile Arg Cys Leu 
                165                 170                 175     


Ser Ser Ser Ala Val Ala Asn Arg Ser Lys Lys Ser Arg Ala Leu Phe 
            180                 185                 190         


Leu Ser Ala Ala Val Phe Cys Ile Phe Ile Ile Cys Phe Gly Pro Thr 
        195                 200                 205             


Asn Val Leu Leu Ile Ala His Tyr Ser Phe Leu Ser His Thr Ser Thr 
    210                 215                 220                 


Thr Glu Ala Ala Tyr Phe Ala Tyr Leu Leu Cys Val Cys Val Ser Ser 
225                 230                 235                 240 


Ile Ser Cys Cys Ile Asp Pro Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu 
                245                 250                 255     


Cys Gln Arg Tyr Val Tyr Ser Ile Leu Cys Cys Lys Glu Ser Ser Asp 
            260                 265                 270         


Pro Ser Ser Tyr Asn Ser Ser Gly Gln Leu Met Ala Ser Lys Met Asp 
        275                 280                 285             


Thr Cys Ser Ser Asn Leu Asn Asn Ser Ile Tyr Lys Lys Leu Leu Thr 
    290                 295                 300                 


<210>  186
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Gly Pro Arg Arg Leu Leu Leu Val Ala Ala Cys Phe Ser Leu Cys 
1               5                   10                  15      


Gly Pro Leu Leu Ser Ala Arg Thr Arg Ala Arg Arg Pro Glu Ser Lys 
            20                  25                  30          


Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu Leu Arg Asn Pro 
        35                  40                  45              


Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu Lys Asn Glu Ser 
    50                  55                  60                  


Gly Leu Thr Glu Tyr Arg Leu Val Ser Ile Asn Lys Ser Ser Pro Leu 
65                  70                  75                  80  


Gln Lys Gln Leu Pro Ala Phe Ile Ser Glu Asp Ala Ser Gly Tyr Leu 
                85                  90                  95      


Thr Ser Ser Trp Leu Thr Leu Phe Val Pro Ser Val Tyr Thr Gly Val 
            100                 105                 110         


Phe Val Val Ser Leu Pro Leu Asn Ile Met Ala Ile Val Val Phe Ile 
        115                 120                 125             


Leu Lys Met Lys Val Lys Lys Pro Ala Val Val Tyr Met Leu His Leu 
    130                 135                 140                 


Ala Thr Ala Asp Val Leu Phe Val Ser Val Leu Pro Phe Lys Ile Ser 
145                 150                 155                 160 


Tyr Tyr Phe Ser Gly Ser Asp Trp Gln Phe Gly Ser Glu Leu Cys Arg 
                165                 170                 175     


Phe Val Thr Ala Ala Phe Tyr Cys Asn Met Tyr Ala Ser Ile Leu Leu 
            180                 185                 190         


Met Thr Val Ile Ser Ile Asp Arg Phe Leu Ala Val Val Tyr Pro Met 
        195                 200                 205             


Gln Ser Leu Ser Trp Arg Thr Leu Gly Arg Ala Ser Phe Thr Cys Leu 
    210                 215                 220                 


Ala Ile Trp Ala Leu Ala Ile Ala Gly Val Val Pro Leu Leu Leu Lys 
225                 230                 235                 240 


Glu Gln Thr Ile Gln Val Pro Gly Leu Asn Ile Thr Thr Cys His Asp 
                245                 250                 255     


Val Leu Asn Glu Thr Leu Leu Glu Gly Tyr Tyr Ala Tyr Tyr Phe Ser 
            260                 265                 270         


Ala Phe Ser Ala Val Phe Phe Phe Val Pro Leu Ile Ile Ser Thr Val 
        275                 280                 285             


Cys Tyr Val Ser Ile Ile Arg Cys Leu Ser Ser Ser Ala Val Ala Asn 
    290                 295                 300                 


Arg Ser Lys Lys Ser Arg Ala Leu Phe Leu Ser Ala Ala Val Phe Cys 
305                 310                 315                 320 


Ile Phe Ile Ile Cys Phe Gly Pro Thr Asn Val Leu Leu Ile Ala His 
                325                 330                 335     


Tyr Ser Phe Leu Ser His Thr Ser Thr Thr Glu Ala Ala Tyr Phe Ala 
            340                 345                 350         


Tyr Leu Leu Cys Val Cys Val Ser Ser Ile Ser Cys Cys Ile Asp Pro 
        355                 360                 365             


Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser 
    370                 375                 380                 


Ile Leu Cys Cys Lys Glu Ser Ser Asp Pro Ser Ser Tyr Asn Ser Ser 
385                 390                 395                 400 


Gly Gln Leu Met Ala Ser Lys Met Asp Thr Cys Ser Ser Asn Leu Asn 
                405                 410                 415     


Asn Ser Ile Tyr Lys Lys Leu Leu Thr 
            420                 425 


<210>  187
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Glu Asn Asp Thr Asn Asn Leu Ala Lys Pro Thr Leu Pro Ile Lys 
1               5                   10                  15      


Thr Phe Arg Gly Ala Pro Pro Asn Ser Phe Glu Glu Phe Pro Phe Ser 
            20                  25                  30          


Ala Leu Glu Gly Trp Thr Gly Ala Thr Ile Thr Val Lys Ile Lys Cys 
        35                  40                  45              


Pro Glu Glu Ser Ala Ser His Leu His Val Lys Asn Ala Thr Met Gly 
    50                  55                  60                  


Tyr Leu Thr Ser Ser Leu Ser Thr Lys Leu Ile Pro Ala Ile Tyr Leu 
65                  70                  75                  80  


Leu Val Phe Val Val Gly Val Pro Ala Asn Ala Val Thr Leu Trp Met 
                85                  90                  95      


Leu Phe Phe Arg Thr Arg Ser Ile Cys Thr Thr Val Phe Tyr Thr Asn 
            100                 105                 110         


Leu Ala Ile Ala Asp Phe Leu Phe Cys Val Thr Leu Pro Phe Lys Ile 
        115                 120                 125             


Ala Tyr His Leu Asn Gly Asn Asn Trp Val Phe Gly Glu Val Leu Cys 
    130                 135                 140                 


Arg Ala Thr Thr Val Ile Phe Tyr Gly Asn Met Tyr Cys Ser Ile Leu 
145                 150                 155                 160 


Leu Leu Ala Cys Ile Ser Ile Asn Arg Tyr Leu Ala Ile Val His Pro 
                165                 170                 175     


Phe Thr Tyr Arg Gly Leu Pro Lys His Thr Tyr Ala Leu Val Thr Cys 
            180                 185                 190         


Gly Leu Val Trp Ala Thr Val Phe Leu Tyr Met Leu Pro Phe Phe Ile 
        195                 200                 205             


Leu Lys Gln Glu Tyr Tyr Leu Val Gln Pro Asp Ile Thr Thr Cys His 
    210                 215                 220                 


Asp Val His Asn Thr Cys Glu Ser Ser Ser Pro Phe Gln Leu Tyr Tyr 
225                 230                 235                 240 


Phe Ile Ser Leu Ala Phe Phe Gly Phe Leu Ile Pro Phe Val Leu Ile 
                245                 250                 255     


Ile Tyr Cys Tyr Ala Ala Ile Ile Arg Thr Leu Asn Ala Tyr Asp His 
            260                 265                 270         


Arg Trp Leu Trp Tyr Val Lys Ala Ser Leu Leu Ile Leu Val Ile Phe 
        275                 280                 285             


Thr Ile Cys Phe Ala Pro Ser Asn Ile Ile Leu Ile Ile His His Ala 
    290                 295                 300                 


Asn Tyr Tyr Tyr Asn Asn Thr Asp Gly Leu Tyr Phe Ile Tyr Leu Ile 
305                 310                 315                 320 


Ala Leu Cys Leu Gly Ser Leu Asn Ser Cys Leu Asp Pro Phe Leu Tyr 
                325                 330                 335     


Phe Leu Met Ser Lys Thr Arg Asn His Ser Thr Ala Tyr Leu Thr Lys 
            340                 345                 350         


<210>  188
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Lys Ala Leu Ile Phe Ala Ala Ala Gly Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Phe Cys Gln Ser Gly Met Glu Asn Asp Thr Asn Asn Leu Ala Lys 
            20                  25                  30          


Pro Thr Leu Pro Ile Lys Thr Phe Arg Gly Ala Pro Pro Asn Ser Phe 
        35                  40                  45              


Glu Glu Phe Pro Phe Ser Ala Leu Glu Gly Trp Thr Gly Ala Thr Ile 
    50                  55                  60                  


Thr Val Lys Ile Lys Cys Pro Glu Glu Ser Ala Ser His Leu His Val 
65                  70                  75                  80  


Lys Asn Ala Thr Met Gly Tyr Leu Thr Ser Ser Leu Ser Thr Lys Leu 
                85                  90                  95      


Ile Pro Ala Ile Tyr Leu Leu Val Phe Val Val Gly Val Pro Ala Asn 
            100                 105                 110         


Ala Val Thr Leu Trp Met Leu Phe Phe Arg Thr Arg Ser Ile Cys Thr 
        115                 120                 125             


Thr Val Phe Tyr Thr Asn Leu Ala Ile Ala Asp Phe Leu Phe Cys Val 
    130                 135                 140                 


Thr Leu Pro Phe Lys Ile Ala Tyr His Leu Asn Gly Asn Asn Trp Val 
145                 150                 155                 160 


Phe Gly Glu Val Leu Cys Arg Ala Thr Thr Val Ile Phe Tyr Gly Asn 
                165                 170                 175     


Met Tyr Cys Ser Ile Leu Leu Leu Ala Cys Ile Ser Ile Asn Arg Tyr 
            180                 185                 190         


Leu Ala Ile Val His Pro Phe Thr Tyr Arg Gly Leu Pro Lys His Thr 
        195                 200                 205             


Tyr Ala Leu Val Thr Cys Gly Leu Val Trp Ala Thr Val Phe Leu Tyr 
    210                 215                 220                 


Met Leu Pro Phe Phe Ile Leu Lys Gln Glu Tyr Tyr Leu Val Gln Pro 
225                 230                 235                 240 


Asp Ile Thr Thr Cys His Asp Val His Asn Thr Cys Glu Ser Ser Ser 
                245                 250                 255     


Pro Phe Gln Leu Tyr Tyr Phe Ile Ser Leu Ala Phe Phe Gly Phe Leu 
            260                 265                 270         


Ile Pro Phe Val Leu Ile Ile Tyr Cys Tyr Ala Ala Ile Ile Arg Thr 
        275                 280                 285             


Leu Asn Ala Tyr Asp His Arg Trp Leu Trp Tyr Val Lys Ala Ser Leu 
    290                 295                 300                 


Leu Ile Leu Val Ile Phe Thr Ile Cys Phe Ala Pro Ser Asn Ile Ile 
305                 310                 315                 320 


Leu Ile Ile His His Ala Asn Tyr Tyr Tyr Asn Asn Thr Asp Gly Leu 
                325                 330                 335     


Tyr Phe Ile Tyr Leu Ile Ala Leu Cys Leu Gly Ser Leu Asn Ser Cys 
            340                 345                 350         


Leu Asp Pro Phe Leu Tyr Phe Leu Met Ser Lys Thr Arg Asn His Ser 
        355                 360                 365             


Thr Ala Tyr Leu Thr Lys 
    370                 


<210>  189
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Leu 
                85                  90                  95      


Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn 
            100                 105                 110         


Gly Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu 
        115                 120                 125             


Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn 
    130                 135                 140                 


Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe 
145                 150                 155                 160 


Asn Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr 
                165                 170                 175     


Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn 
            180                 185                 190         


Gly Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val 
        195                 200                 205             


Ile Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn 
    210                 215                 220                 


Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe 
225                 230                 235                 240 


Ile Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro 
                245                 250                 255     


Val Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr 
            260                 265                 270         


Trp Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln 
        275                 280                 285             


Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr 
    290                 295                 300                 


Trp Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly 
305                 310                 315                 320 


Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala 
                325                 330                 335     


Ile Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile 
            340                 345                 350         


His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly 
        355                 360                 365             


Lys Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe 
    370                 375                 380                 


Tyr Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr 
385                 390                 395                 400 


Arg Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys 
                405                 410                 415     


His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp 
            420                 425                 430         


Tyr Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile 
        435                 440                 445             


Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu 
    450                 455                 460                 


Glu Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys 
465                 470                 475                 480 


Glu Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys 
                485                 490                 495     


Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu 
            500                 505                 510         


Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe 
        515                 520                 525             


Ala Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile 
    530                 535                 540                 


Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu 
545                 550                 555                 560 


Tyr Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile 
                565                 570                 575     


Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg 
            580                 585                 590         


Ile Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala 
        595                 600                 605             


Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro 
    610                 615                 620                 


Val Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met 
625                 630                 635                 640 


Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr 
                645                 650                 655     


Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile 
            660                 665                 670         


His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile 
        675                 680                 685             


Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr 
    690                 695                 700                 


Ser Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr 
705                 710                 715                 720 


Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
                725                 730                 735 


<210>  190
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  191
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Leu Leu Trp Val Ile Leu Leu Val Leu Ala Pro Val Ser Gly Gln 
1               5                   10                  15      


Phe Ala Arg Thr Pro Arg Pro Ile Ile Phe Leu Gln Pro Pro Trp Thr 
            20                  25                  30          


Thr Val Phe Gln Gly Glu Arg Val Thr Leu Thr Cys Lys Gly Phe Arg 
        35                  40                  45              


Phe Tyr Ser Pro Gln Lys Thr Lys Trp Tyr His Arg Tyr Leu Gly Lys 
    50                  55                  60                  


Glu Ile Leu Arg Glu Thr Pro Asp Asn Ile Leu Glu Val Gln Glu Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Ala Gln Gly Ser Pro Leu Ser Ser Pro Val 
                85                  90                  95      


His Leu Asp Phe Ser Ser Ala Ser Leu Ile Leu Gln Ala Pro Leu Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Ser Val Val Leu Arg Cys Arg Ala Lys Ala Glu 
        115                 120                 125             


Val Thr Leu Asn Asn Thr Ile Tyr Lys Asn Asp Asn Val Leu Ala Phe 
    130                 135                 140                 


Leu Asn Lys Arg Thr Asp Phe His Ile Pro His Ala Cys Leu Lys Asp 
145                 150                 155                 160 


Asn Gly Ala Tyr Arg Cys Thr Gly Tyr Lys Glu Ser Cys Cys Pro Val 
                165                 170                 175     


Ser Ser Asn Thr Val Lys Ile Gln Val Gln Glu Pro Phe Thr Arg Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Phe Gln Pro Ile Ser Gly Asn Pro Val Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Leu Glu Arg Ser Asp Val Pro Leu 
    210                 215                 220                 


Arg Phe Arg Phe Phe Arg Asp Asp Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Leu Ser Pro Asn Phe Gln Ile Thr Ala Met Trp Ser Lys Asp Ser Gly 
                245                 250                 255     


Phe Tyr Trp Cys Lys Ala Ala Thr Met Pro Tyr Ser Val Ile Ser Asp 
            260                 265                 270         


Ser Pro Arg Ser Trp Ile Gln Val Gln Ile Pro Ala Ser His Pro Val 
        275                 280                 285             


Leu Thr Leu Ser Pro Glu Lys Ala Leu Asn Phe Glu Gly Thr Lys Val 
    290                 295                 300                 


Thr Leu His Cys Glu Thr Gln Glu Asp Ser Leu Arg Thr Leu Tyr Arg 
305                 310                 315                 320 


Phe Tyr His Glu Gly Val Pro Leu Arg His Lys Ser Val Arg Cys Glu 
                325                 330                 335     


Arg Gly Ala Ser Ile Ser Phe Ser Leu Thr Thr Glu Asn Ser Gly Asn 
            340                 345                 350         


Tyr Tyr Cys Thr Ala Asp Asn Gly Leu Gly Ala Lys Pro Ser Lys Ala 
        355                 360                 365             


Val Ser Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu Asn Leu 
    370                 375                 380                 


Ser Ser Pro Glu Asp Leu Ile Phe Glu Gly Ala Lys Val Thr Leu His 
385                 390                 395                 400 


Cys Glu Ala Gln Arg Gly Ser Leu Pro Ile Leu Tyr Gln Phe His His 
                405                 410                 415     


Glu Gly Ala Ala Leu Glu Arg Arg Ser Ala Asn Ser Ala Gly Gly Val 
            420                 425                 430         


Ala Ile Ser Phe Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Tyr Cys 
        435                 440                 445             


Thr Ala Asp Asn Gly Phe Gly Pro Gln Arg Ser Lys Ala Val Ser Leu 
    450                 455                 460                 


Ser Val Thr Val Pro Val Ser His Pro Val Leu Thr Leu Ser Ser Ala 
465                 470                 475                 480 


Glu Ala Leu Thr Phe Glu Gly Ala Thr Val Thr Leu His Cys Glu Val 
                485                 490                 495     


Gln Arg Gly Ser Pro Gln Ile Leu Tyr Gln Phe Tyr His Glu Asp Met 
            500                 505                 510         


Pro Leu Trp Ser Ser Ser Thr Pro Ser Val Gly Arg Val Ser Phe Ser 
        515                 520                 525             


Phe Ser Leu Thr Glu Gly His Ser Gly Asn Tyr Tyr Cys Thr Ala Asp 
    530                 535                 540                 


Asn Gly Phe Gly Pro Gln Arg Ser Glu Val Val Ser Leu Phe Val Thr 
545                 550                 555                 560 


Val Pro Val Ser Arg Pro Ile Leu Thr Leu Arg Val Pro Arg Ala Gln 
                565                 570                 575     


Ala Val Val Gly Asp Leu Leu Glu Leu His Cys Glu Ala Pro Arg Gly 
            580                 585                 590         


Ser Pro Pro Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly 
        595                 600                 605             


Ser Ser Ser Ala Pro Ser Gly Gly Glu Ala Ser Phe Asn Leu Ser Leu 
    610                 615                 620                 


Thr Ala Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu 
625                 630                 635                 640 


Val Ala Gln His Ser Asp Thr Ile Ser Leu Ser Val Ile Val Pro Val 
                645                 650                 655     


Ser Arg Pro Ile Leu Thr Phe Arg Ala Pro Arg Ala Gln Ala Val Val 
            660                 665                 670         


Gly Asp Leu Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Ser Pro 
        675                 680                 685             


Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly Lys Ile Ser 
    690                 695                 700                 


Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu 
705                 710                 715                 720 


His Ser Gly Ile Tyr Ser Cys Glu Ala Asp Asn Gly Leu Glu Ala Gln 
                725                 730                 735     


Arg Ser Glu Met Val Thr Leu Lys Val Ala Val Pro Val Ser Arg Pro 
            740                 745                 750         


Val Leu Thr Leu Arg Ala Pro Gly Thr His Ala Ala Val Gly Asp Leu 
        755                 760                 765             


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Leu Ile Leu Tyr 
    770                 775                 780                 


Arg Phe Phe His Glu Asp Val Thr Leu Gly Asn Arg Ser Ser Pro Ser 
785                 790                 795                 800 


Gly Gly Ala Ser Leu Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
                805                 810                 815     


Tyr Ser Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln Arg Ser Glu Thr 
            820                 825                 830         


Val Thr Leu Tyr Ile Thr Gly Leu Thr Ala Asn Arg Ser Gly Pro Phe 
        835                 840                 845             


Ala Thr Gly Val Ala Gly Gly Leu Leu Ser Ile Ala Gly Leu Ala Ala 
    850                 855                 860                 


Gly Ala Leu Leu Leu Tyr Cys Trp Leu Ser Arg Lys Ala Gly Arg Lys 
865                 870                 875                 880 


Pro Ala Ser Asp Pro Ala Arg Ser Pro Ser Asp Ser Asp Ser Gln Glu 
                885                 890                 895     


Pro Thr Tyr His Asn Val Pro Ala Trp Glu Glu Leu Gln Pro Val Tyr 
            900                 905                 910         


Thr Asn Glu Glu Lys Met Trp Phe Thr Gln Lys Tyr Gly Ser Ser Lys 
        915                 920                 925             


Arg Lys Arg Asn Met Gln Trp Pro Leu Thr Pro Gly Ile Ser Gly Thr 
    930                 935                 940                 


Arg Val Pro Leu Ser Ser Thr Leu Lys Leu Arg Trp Arg Gln Pro Arg 
945                 950                 955                 960 


Phe Pro Asp Pro Cys Ser Trp Leu Pro Gln Leu Leu Thr Asp Glu Ser 
                965                 970                 975     


Thr Arg Leu Ser Asn Cys Cys Phe Ser Leu Cys Thr Pro Lys Phe Pro 
            980                 985                 990         


Leu Gly Glu Lys Gln His 
        995             


<210>  192
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Leu Leu Trp Val Ile Leu Leu Val Leu Ala Pro Val Ser Gly Gln 
1               5                   10                  15      


Phe Ala Arg Thr Pro Arg Pro Ile Ile Phe Leu Gln Pro Pro Trp Thr 
            20                  25                  30          


Thr Val Phe Gln Gly Glu Arg Val Thr Leu Thr Cys Lys Gly Phe Arg 
        35                  40                  45              


Phe Tyr Ser Pro Gln Lys Thr Lys Trp Tyr His Arg Tyr Leu Gly Lys 
    50                  55                  60                  


Glu Ile Leu Arg Glu Thr Pro Asp Asn Ile Leu Glu Val Gln Glu Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Ala Gln Gly Ser Pro Leu Ser Ser Pro Val 
                85                  90                  95      


His Leu Asp Phe Ser Ser Ala Ser Leu Ile Leu Gln Ala Pro Leu Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Ser Val Val Leu Arg Cys Arg Ala Lys Ala Glu 
        115                 120                 125             


Val Thr Leu Asn Asn Thr Ile Tyr Lys Asn Asp Asn Val Leu Ala Phe 
    130                 135                 140                 


Leu Asn Lys Arg Thr Asp Phe His Ile Pro His Ala Cys Leu Lys Asp 
145                 150                 155                 160 


Asn Gly Ala Tyr Arg Cys Thr Gly Tyr Lys Glu Ser Cys Cys Pro Val 
                165                 170                 175     


Ser Ser Asn Thr Val Lys Ile Gln Val Gln Glu Pro Phe Thr Arg Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Phe Gln Pro Ile Ser Gly Asn Pro Val Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Leu Glu Arg Ser Asp Val Pro Leu 
    210                 215                 220                 


Arg Phe Arg Phe Phe Arg Asp Asp Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Leu Ser Pro Asn Phe Gln Ile Thr Ala Met Trp Ser Lys Asp Ser Gly 
                245                 250                 255     


Phe Tyr Trp Cys Lys Ala Ala Thr Met Pro Tyr Ser Val Ile Ser Asp 
            260                 265                 270         


Ser Pro Arg Ser Trp Ile Gln Val Gln Ile Pro Ala Ser His Pro Val 
        275                 280                 285             


Leu Thr Leu Ser Pro Glu Lys Ala Leu Asn Phe Glu Gly Thr Lys Val 
    290                 295                 300                 


Thr Leu His Cys Glu Thr Gln Glu Asp Ser Leu Arg Thr Leu Tyr Arg 
305                 310                 315                 320 


Phe Tyr His Glu Gly Val Pro Leu Arg His Lys Ser Val Arg Cys Glu 
                325                 330                 335     


Arg Gly Ala Ser Ile Ser Phe Ser Leu Thr Thr Glu Asn Ser Gly Asn 
            340                 345                 350         


Tyr Tyr Cys Thr Ala Asp Asn Gly Leu Gly Ala Lys Pro Ser Lys Ala 
        355                 360                 365             


Val Ser Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu Asn Leu 
    370                 375                 380                 


Ser Ser Pro Glu Asp Leu Ile Phe Glu Gly Ala Lys Val Thr Leu His 
385                 390                 395                 400 


Cys Glu Ala Gln Arg Gly Ser Leu Pro Ile Leu Tyr Gln Phe His His 
                405                 410                 415     


Glu Gly Ala Ala Leu Glu Arg Arg Ser Ala Asn Ser Ala Gly Gly Val 
            420                 425                 430         


Ala Ile Ser Phe Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Tyr Cys 
        435                 440                 445             


Thr Ala Asp Asn Gly Phe Gly Pro Gln Arg Ser Lys Ala Val Ser Leu 
    450                 455                 460                 


Ser Val Thr Val Pro Val Ser His Pro Val Leu Thr Leu Ser Ser Ala 
465                 470                 475                 480 


Glu Ala Leu Thr Phe Glu Gly Ala Thr Val Thr Leu His Cys Glu Val 
                485                 490                 495     


Gln Arg Gly Ser Pro Gln Ile Leu Tyr Gln Phe Tyr His Glu Asp Met 
            500                 505                 510         


Pro Leu Trp Ser Ser Ser Thr Pro Ser Val Gly Arg Val Ser Phe Ser 
        515                 520                 525             


Phe Ser Leu Thr Glu Gly His Ser Gly Asn Tyr Tyr Cys Thr Ala Asp 
    530                 535                 540                 


Asn Gly Phe Gly Pro Gln Arg Ser Glu Val Val Ser Leu Phe Val Thr 
545                 550                 555                 560 


Val Pro Val Ser Arg Pro Ile Leu Thr Leu Arg Val Pro Arg Ala Gln 
                565                 570                 575     


Ala Val Val Gly Asp Leu Leu Glu Leu His Cys Glu Ala Pro Arg Gly 
            580                 585                 590         


Ser Pro Pro Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly 
        595                 600                 605             


Ser Ser Ser Ala Pro Ser Gly Gly Glu Ala Ser Phe Asn Leu Ser Leu 
    610                 615                 620                 


Thr Ala Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu 
625                 630                 635                 640 


Val Ala Gln His Ser Asp Thr Ile Ser Leu Ser Val Ile Val Pro Val 
                645                 650                 655     


Ser Arg Pro Ile Leu Thr Phe Arg Ala Pro Arg Ala Gln Ala Val Val 
            660                 665                 670         


Gly Asp Leu Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Ser Pro 
        675                 680                 685             


Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly Lys Ile Ser 
    690                 695                 700                 


Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu 
705                 710                 715                 720 


His Ser Gly Ile Tyr Ser Cys Glu Ala Asp Asn Gly Leu Glu Ala Gln 
                725                 730                 735     


Arg Ser Glu Met Val Thr Leu Lys Val Ala Val Pro Val Ser Arg Pro 
            740                 745                 750         


Val Leu Thr Leu Arg Ala Pro Gly Thr His Ala Ala Val Gly Asp Leu 
        755                 760                 765             


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Leu Ile Leu Tyr 
    770                 775                 780                 


Arg Phe Phe His Glu Asp Val Thr Leu Gly Asn Arg Ser Ser Pro Ser 
785                 790                 795                 800 


Gly Gly Ala Ser Leu Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
                805                 810                 815     


Tyr Ser Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln Arg Ser Glu Thr 
            820                 825                 830         


Val Thr Leu Tyr Ile Thr Gly Leu Thr Ala Asn Arg Ser Gly Pro Phe 
        835                 840                 845             


Ala Thr Gly Val Ala Gly Gly Leu Leu Ser Ile Ala Gly Leu Ala Ala 
    850                 855                 860                 


Gly Ala Leu Leu Leu Tyr Cys Trp Leu Ser Arg Lys Ala Gly Arg Lys 
865                 870                 875                 880 


Pro Ala Ser Asp Pro Ala Arg Ser Pro Ser Asp Ser Asp Ser Gln Glu 
                885                 890                 895     


Pro Thr Tyr His Asn Val Pro Ala Trp Glu Glu Leu Gln Pro Val Tyr 
            900                 905                 910         


Thr Asn Ala Asn Pro Arg Gly Glu Asn Val Val Tyr Ser Glu Val Arg 
        915                 920                 925             


Ile Ile Gln Glu Lys Lys Lys His Ala Val Ala Ser Asp Pro Arg His 
    930                 935                 940                 


Leu Arg Asn Lys Gly Ser Pro Ile Ile Tyr Ser Glu Val Lys Val Ala 
945                 950                 955                 960 


Ser Thr Pro Val Ser Gly Ser Leu Phe Leu Ala Ser Ser Ala Pro His 
                965                 970                 975     


Arg 
    


<210>  193
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Lys His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu 
            660                 665                 670         


Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val 
        675                 680                 685             


Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala 
    690                 695                 700                 


Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
705                 710                 715                 


<210>  194
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Thr Ala Gly Ser Ser Tyr Pro Leu Phe Leu Ala Ala Tyr Ala Cys 
1               5                   10                  15      


Thr Gly Cys Leu Ala Glu Arg Leu Gly Trp Phe Ile Lys Ser Ser Asn 
            20                  25                  30          


Glu Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp 
        35                  40                  45              


Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln 
    50                  55                  60                  


Ile Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln 
65                  70                  75                  80  


Ile Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala 
                85                  90                  95      


His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr 
            100                 105                 110         


Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu 
        115                 120                 125             


Phe Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro 
    130                 135                 140                 


Pro Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val 
145                 150                 155                 160 


Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp 
                165                 170                 175     


Met Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys 
            180                 185                 190         


Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys 
        195                 200                 205             


Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val 
    210                 215                 220                 


Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg 
225                 230                 235                 240 


Gly Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly 
                245                 250                 255     


Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val 
            260                 265                 270         


Gly Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln 
        275                 280                 285             


Lys Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp 
    290                 295                 300                 


Arg Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly 
305                 310                 315                 320 


Asn Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu 
                325                 330                 335     


Val Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu 
            340                 345                 350         


Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe 
        355                 360                 365             


Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val 
    370                 375                 380                 


Arg Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr 
385                 390                 395                 400 


Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser 
                405                 410                 415     


Thr Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val 
            420                 425                 430         


Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg 
        435                 440                 445             


Val Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys 
    450                 455                 460                 


Glu Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu 
465                 470                 475                 480 


Ser Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg 
                485                 490                 495     


Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg 
            500                 505                 510         


Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr 
        515                 520                 525             


Asn Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr 
    530                 535                 540                 


Glu Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr 
545                 550                 555                 560 


Val Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile 
                565                 570                 575     


Val Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr 
            580                 585                 590         


Ala Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys 
        595                 600                 605             


Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe 
    610                 615                 620                 


Thr Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys 
625                 630                 635                 640 


Ser Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu 
                645                 650                 655     


Glu Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr 
            660                 665                 670         


Arg His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu 
        675                 680                 685             


Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val 
    690                 695                 700                 


Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala 
705                 710                 715                 720 


Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
                725                 730                 735 


<210>  195
<211>  704
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Thr Ala Gly Ser Ser Tyr Pro Leu Phe Leu Ala Ala Tyr Ala Cys 
1               5                   10                  15      


Thr Gly Cys Leu Ala Glu Arg Leu Gly Trp Phe Ile Lys Ser Ser Asn 
            20                  25                  30          


Glu Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp 
        35                  40                  45              


Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln 
    50                  55                  60                  


Ile Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln 
65                  70                  75                  80  


Ile Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala 
                85                  90                  95      


His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr 
            100                 105                 110         


Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu 
        115                 120                 125             


Phe Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro 
    130                 135                 140                 


Pro Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val 
145                 150                 155                 160 


Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp 
                165                 170                 175     


Met Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys 
            180                 185                 190         


Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys 
        195                 200                 205             


Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val 
    210                 215                 220                 


Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg 
225                 230                 235                 240 


Gly Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly 
                245                 250                 255     


Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val 
            260                 265                 270         


Gly Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln 
        275                 280                 285             


Lys Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp 
    290                 295                 300                 


Arg Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly 
305                 310                 315                 320 


Asn Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu 
                325                 330                 335     


Val Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu 
            340                 345                 350         


Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe 
        355                 360                 365             


Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val 
    370                 375                 380                 


Arg Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr 
385                 390                 395                 400 


Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser 
                405                 410                 415     


Thr Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val 
            420                 425                 430         


Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg 
        435                 440                 445             


Val Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys 
    450                 455                 460                 


Glu Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu 
465                 470                 475                 480 


Ser Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg 
                485                 490                 495     


Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg 
            500                 505                 510         


Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr 
        515                 520                 525             


Asn Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr 
    530                 535                 540                 


Glu Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr 
545                 550                 555                 560 


Val Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile 
                565                 570                 575     


Val Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr 
            580                 585                 590         


Ala Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys 
        595                 600                 605             


Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe 
    610                 615                 620                 


Thr Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys 
625                 630                 635                 640 


Ser Lys His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly 
                645                 650                 655     


Glu Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys 
            660                 665                 670         


Val Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val 
        675                 680                 685             


Ala Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
    690                 695                 700                 


<210>  196
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg Gly Ser Leu Lys 
1               5                   10                  15      


Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn Phe Ser Thr Gln 
            20                  25                  30          


Lys Val Lys Met His Ile His Ser Thr Asn Glu Val Thr Arg Ile Tyr 
        35                  40                  45              


Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro Asp Arg Tyr Val 
    50                  55                  60                  


Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly Gly Ile Asp Pro 
65                  70                  75                  80  


Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg Ser Phe Gly Thr 
                85                  90                  95      


Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile Leu Phe Ala Ser 
            100                 105                 110         


Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu 
        115                 120                 125             


Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala Tyr Ile Asn Ala 
    130                 135                 140                 


Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro 
145                 150                 155                 160 


Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu Leu Lys Ser Pro 
                165                 170                 175     


Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser Trp Thr Lys Lys 
            180                 185                 190         


Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile Ser Lys Leu Gly 
        195                 200                 205             


Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu Gly Ile Ala Ser 
    210                 215                 220                 


Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn Lys Phe Ser Gly 
225                 230                 235                 240 


Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu Leu Val Glu Lys 
                245                 250                 255     


Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val Ala Gln Val Arg 
            260                 265                 270         


Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val Leu Pro Phe Asp 
        275                 280                 285             


Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala Asp Lys Ile Tyr 
    290                 295                 300                 


Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr Tyr Ser Val Ser 
305                 310                 315                 320 


Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr Glu Ile Ala Ser 
                325                 330                 335     


Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser Asn Pro Ile Val 
            340                 345                 350         


Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu Arg Ala Phe Ile 
        355                 360                 365             


Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg His Val Ile Tyr 
    370                 375                 380                 


Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile 
385                 390                 395                 400 


Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp Pro Ser Lys Ala 
                405                 410                 415     


Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala Phe Thr Val Gln 
            420                 425                 430         


Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
        435                 440         


<210>  197
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  198
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  199
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  200
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  201
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  202
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Gly Arg Gly Tyr Ser Gly Ala Leu Gln Ala Arg Gly Gly Leu Glu 
1               5                   10                  15      


Glu Pro Leu Glu Arg Gly Leu Arg Gly Pro Ser Phe Thr Gln Ser Pro 
            20                  25                  30          


Leu His Gly Ala Ala Ala Ala Tyr Leu Ser Ala Gln Arg Asp Ala Ser 
        35                  40                  45              


Leu Pro Val Pro Gly Gln Arg Ser Asp Met Gln Lys Val Thr Leu Gly 
    50                  55                  60                  


Leu Leu Val Phe Leu Ala Gly Phe Pro Val Leu Asp Ala Asn Asp Leu 
65                  70                  75                  80  


Glu Asp Lys Asn Ser Pro Phe Tyr Tyr Asp Trp His Ser Leu Gln Val 
                85                  90                  95      


Gly Gly Leu Ile Cys Ala Gly Val Leu Cys Ala Met Gly Ile Ile Ile 
            100                 105                 110         


Val Met Ser Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly His 
        115                 120                 125             


His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln Ser 
    130                 135                 140                 


<210>  203
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Glu Trp Arg Ser Ser Gly 
    50                  55                  60                  


Glu Gln Ala Gly Arg Gly Trp Gly Ser Pro Pro Leu Thr Thr Gln Leu 
65                  70                  75                  80  


Ser Pro Thr Gly Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly 
                85                  90                  95      


<210>  204
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Gly Glu Ser Pro Cys Pro Leu Ser Pro Pro His Asn Pro Thr Tyr Cys 
        35                  40                  45              


Leu Val Pro Arg Val Pro Ile Gln Gly Trp Gly Leu Thr 
    50                  55                  60      


<210>  205
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Gly Glu Ser Pro Cys Pro Leu Ser Pro Pro His Asn Pro Thr Tyr Cys 
        35                  40                  45              


Leu Val Pro Arg Val Pro Ile Gln Gly Trp Gly Leu Thr 
    50                  55                  60      


<210>  206
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Ala Lys Cys Lys Cys Lys 
    50                  55                  60                  


Phe Gly Gln Lys Ser Gly His His Pro Gly Glu Thr Pro Pro Leu Ile 
65                  70                  75                  80  


Thr Pro Gly Ser Ala Gln Ser 
                85          


<210>  207
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Glu Trp Arg Ser Ser Gly 
    50                  55                  60                  


Glu Gln Ala Gly Arg Gly Trp Gly Ser Pro Pro Leu Thr Thr Gln Leu 
65                  70                  75                  80  


Ser Pro Thr Gly Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly 
                85                  90                  95      


His His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln 
            100                 105                 110         


Ser 
    


<210>  208
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Ala Lys Cys Lys Cys Lys 
    50                  55                  60                  


Phe Gly Gln Lys Ser Gly His His Pro Gly Glu Thr Pro Pro Leu Ile 
65                  70                  75                  80  


Thr Pro Gly Ser Ala Gln Ser 
                85          


<210>  209
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Glu Trp Arg Ser Ser Gly 
    50                  55                  60                  


Glu Gln Ala Gly Arg Gly Trp Gly Ser Pro Pro Leu Thr Thr Gln Leu 
65                  70                  75                  80  


Ser Pro Thr Gly Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly 
                85                  90                  95      


His His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln 
            100                 105                 110         


Ser 
    


<210>  210
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly 
            20                  25                  30          


Tyr Gly Asn Pro Ile Glu Ala Ser Ser Tyr Gly Leu Asp Leu Asp Cys 
        35                  40                  45              


Gly Ala Pro Gly Thr Pro Glu Ala His Val Cys Phe Asp Pro Cys Gln 
    50                  55                  60                  


Asn Tyr Thr Leu Leu Asp Glu Pro Phe Arg Ser Thr Glu Asn Ser Ala 
65                  70                  75                  80  


Gly Ser Gln Gly Cys Asp Lys Asn Met Ser Gly Trp Tyr Arg Phe Val 
                85                  90                  95      


Gly Glu Gly Gly Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg 
            100                 105                 110         


Cys Gln Thr Asp Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu 
        115                 120                 125             


Gly Asp Gly Ile Thr Asn His Thr Ala Cys Ala His Trp Ser Gly Asn 
    130                 135                 140                 


Cys Cys Phe Trp Lys Thr Glu Val Leu Val Lys Ala Cys Pro Gly Gly 
145                 150                 155                 160 


Tyr His Val Tyr Arg Leu Glu Gly Thr Pro Trp Cys Asn Leu Arg Tyr 
                165                 170                 175     


Cys Thr Val Pro Arg Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys 
            180                 185                 190         


Ala Cys Arg Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly 
        195                 200                 205             


Cys Phe Cys Arg Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln 
    210                 215                 220                 


Pro Gln Leu Asp Cys Gly Pro Arg Glu Ile Lys Val Lys Val Asp Lys 
225                 230                 235                 240 


Cys Leu Leu Gly Gly Leu Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu 
                245                 250                 255     


Arg Asp Pro Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp 
            260                 265                 270         


Val Ser Val Thr Ser Pro Val Gln Ala Ser Ala Cys Arg Asn Ile Leu 
        275                 280                 285             


Glu Arg Asn Gln Thr His Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val 
    290                 295                 300                 


Asn Asp Phe Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys 
305                 310                 315                 320 


Ala Tyr Pro Leu Asp Met Lys Val Ser Leu Gln Ala Ala Leu Gln Pro 
                325                 330                 335     


Ile Val Ser Ser Leu Asn Val Ser Val Asp Gly Asn Gly Glu Phe Ile 
            340                 345                 350         


Val Arg Met Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu 
        355                 360                 365             


Gly Asp Ala Val Glu Leu Ser Val Glu Ser Val Leu Tyr Val Gly Ala 
    370                 375                 380                 


Ile Leu Glu Gln Gly Asp Thr Ser Arg Phe Asn Leu Val Leu Arg Asn 
385                 390                 395                 400 


Cys Tyr Ala Thr Pro Thr Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe 
                405                 410                 415     


Ile Ile Arg Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr Ile His Val 
            420                 425                 430         


Glu Glu Asn Gly Gln Ser Ser Glu Ser Arg Phe Ser Val Gln Met Phe 
        435                 440                 445             


Met Phe Ala Gly His Tyr Asp Leu Val Phe Leu His Cys Glu Ile His 
    450                 455                 460                 


Leu Cys Asp Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser 
465                 470                 475                 480 


Gln Val Arg Ser Glu Val Pro Ala Ile Asp Leu Ala Arg Val Leu Asp 
                485                 490                 495     


Leu Gly Pro Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn 
            500                 505                 510         


Gly Thr Pro Ser Thr Ala Gly Phe Leu Val Ala Trp Pro Met Val Leu 
        515                 520                 525             


Leu Thr Val Leu Leu Ala Trp Leu Phe 
    530                 535         


<210>  211
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly 
            20                  25                  30          


Tyr Gly Asn Pro Ile Glu Ala Ser Ser Tyr Gly Leu Asp Leu Asp Cys 
        35                  40                  45              


Gly Ala Pro Gly Thr Pro Glu Ala His Val Cys Phe Asp Pro Cys Gln 
    50                  55                  60                  


Asn Tyr Thr Leu Leu Asp Glu Pro Phe Arg Ser Thr Glu Asn Ser Ala 
65                  70                  75                  80  


Gly Ser Gln Gly Cys Asp Lys Asn Met Ser Gly Trp Tyr Arg Phe Val 
                85                  90                  95      


Gly Glu Gly Gly Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg 
            100                 105                 110         


Cys Gln Thr Asp Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu 
        115                 120                 125             


Gly Asp Gly Ile Thr Asn His Thr Ala Cys Ala His Trp Ser Gly Asn 
    130                 135                 140                 


Cys Cys Phe Trp Lys Thr Glu Val Leu Val Lys Ala Cys Pro Gly Gly 
145                 150                 155                 160 


Tyr His Val Tyr Arg Leu Glu Gly Thr Pro Trp Cys Asn Leu Arg Tyr 
                165                 170                 175     


Cys Thr Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys Ala Cys Arg 
            180                 185                 190         


Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly Cys Phe Cys 
        195                 200                 205             


Arg Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln Pro Gln Leu 
    210                 215                 220                 


Asp Cys Gly Pro Arg Glu Ile Lys Val Lys Val Asp Lys Cys Leu Leu 
225                 230                 235                 240 


Gly Gly Leu Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu Arg Asp Pro 
                245                 250                 255     


Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp Val Ser Val 
            260                 265                 270         


Thr Ser Pro Val Gln Ala Ser Ala Cys Arg Asn Ile Leu Glu Arg Asn 
        275                 280                 285             


Gln Thr His Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val Asn Asp Phe 
    290                 295                 300                 


Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys Ala Tyr Pro 
305                 310                 315                 320 


Leu Asp Met Lys Val Ser Leu Gln Ala Ala Leu Gln Pro Ile Val Ser 
                325                 330                 335     


Ser Leu Asn Val Ser Val Asp Gly Asn Gly Glu Phe Ile Val Arg Met 
            340                 345                 350         


Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu Gly Asp Ala 
        355                 360                 365             


Val Glu Leu Ser Val Glu Ser Val Leu Tyr Val Gly Ala Ile Leu Glu 
    370                 375                 380                 


Gln Gly Asp Thr Ser Arg Phe Asn Leu Val Leu Arg Asn Cys Tyr Ala 
385                 390                 395                 400 


Thr Pro Thr Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe Ile Ile Arg 
                405                 410                 415     


Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr Ile His Val Glu Glu Asn 
            420                 425                 430         


Gly Gln Ser Ser Glu Ser Arg Phe Ser Val Gln Met Phe Met Phe Ala 
        435                 440                 445             


Gly His Tyr Asp Leu Val Phe Leu His Cys Glu Ile His Leu Cys Asp 
    450                 455                 460                 


Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser Gln Val Arg 
465                 470                 475                 480 


Ser Glu Val Pro Ala Ile Asp Leu Ala Arg Val Leu Asp Leu Gly Pro 
                485                 490                 495     


Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn Gly Thr Pro 
            500                 505                 510         


Ser Thr Ala Gly Phe Leu Val Ala Trp Pro Met Val Leu Leu Thr Val 
        515                 520                 525             


Leu Leu Ala Trp Leu Phe 
    530                 


<210>  212
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 
            20                  25                  30          


Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro 
        35                  40                  45              


Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr 
    50                  55                  60                  


Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg 
65                  70                  75                  80  


Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe 
                85                  90                  95      


Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met 
            100                 105                 110         


Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu 
        115                 120                 125             


Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu 
    130                 135                 140                 


Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile 
145                 150                 155                 160 


Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro 
                165                 170                 175     


Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala 
            180                 185                 190         


His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg 
        195                 200                 205             


Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg 
    210                 215                 220                 


Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr 
225                 230                 235                 240 


Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro 
                245                 250                 255     


Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser 
            260                 265                 270         


Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr 
        275                 280                 285             


Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly 
    290                 295                 300                 


Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser 
305                 310                 315                 320 


Ser Gln Ser Ser Val Asp Leu Asp Leu Asn 
                325                 330 


<210>  213
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 
            20                  25                  30          


Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro 
        35                  40                  45              


Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr 
    50                  55                  60                  


Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg 
65                  70                  75                  80  


Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe 
                85                  90                  95      


Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met 
            100                 105                 110         


Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu 
        115                 120                 125             


Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu 
    130                 135                 140                 


Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile 
145                 150                 155                 160 


Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro 
                165                 170                 175     


Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala 
            180                 185                 190         


His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg 
        195                 200                 205             


Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg 
    210                 215                 220                 


Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr 
225                 230                 235                 240 


Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro 
                245                 250                 255     


Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser 
            260                 265                 270         


Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr 
        275                 280                 285             


Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly 
    290                 295                 300                 


Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser 
305                 310                 315                 320 


Ser Gln Ser Ser Val Asp Leu Asp Leu Asn 
                325                 330 


<210>  214
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 
            20                  25                  30          


Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro 
        35                  40                  45              


Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr 
    50                  55                  60                  


Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg 
65                  70                  75                  80  


Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe 
                85                  90                  95      


Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met 
            100                 105                 110         


Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu 
        115                 120                 125             


Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu 
    130                 135                 140                 


Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile 
145                 150                 155                 160 


Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro 
                165                 170                 175     


Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala 
            180                 185                 190         


His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg 
        195                 200                 205             


Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg 
    210                 215                 220                 


Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr 
225                 230                 235                 240 


Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro 
                245                 250                 255     


Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser 
            260                 265                 270         


Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr 
        275                 280                 285             


Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly 
    290                 295                 300                 


Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser 
305                 310                 315                 320 


Ser Gln Ser Ser Val Asp Leu Asp Leu Asn 
                325                 330 


<210>  215
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 
            20                  25                  30          


Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro 
        35                  40                  45              


Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr 
    50                  55                  60                  


Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg 
65                  70                  75                  80  


Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe 
                85                  90                  95      


Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met 
            100                 105                 110         


Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu 
        115                 120                 125             


Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu 
    130                 135                 140                 


Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile 
145                 150                 155                 160 


Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro 
                165                 170                 175     


Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala 
            180                 185                 190         


His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg 
        195                 200                 205             


Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg 
    210                 215                 220                 


Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr 
225                 230                 235                 240 


Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro 
                245                 250                 255     


Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser 
            260                 265                 270         


Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr 
        275                 280                 285             


Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly 
    290                 295                 300                 


Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser 
305                 310                 315                 320 


Ser Gln Ser Ser Val Asp Leu Asp Leu Asn 
                325                 330 


<210>  216
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Glu Thr Glu Lys Lys Ile Trp His 
            340                 345                 350         


Phe Lys Tyr Pro Ile Phe Phe Leu Cys Ile Gly Leu Asp Leu Gln Ile 
        355                 360                 365             


Gly Lys Leu Cys Ala His Ser Gln Gln Arg Gln Tyr Arg Ser Ala Tyr 
    370                 375                 380                 


Tyr Pro Glu Asp Leu Phe Ile Asp Lys Lys Val Leu Lys Val Ala His 
385                 390                 395                 400 


Val Glu His Glu Glu Thr Leu Ser Ser Arg Arg Arg Glu Leu Ile Gln 
                405                 410                 415     


Lys Leu Lys Ser Phe Ile Ser Phe Tyr Ser Ala Leu Pro Gly Tyr Ile 
            420                 425                 430         


Cys Ser His Ser Pro Val Ala Glu Asn Asp Thr Leu Cys Trp Asn Gly 
        435                 440                 445             


Gln Glu Leu Val Glu Arg Tyr Ser Gln Lys Ala Ala Arg Asn Gly Met 
    450                 455                 460                 


Lys Asn Gln Phe Asn Leu His Glu Leu Lys Met Lys Gly Pro Glu Pro 
465                 470                 475                 480 


Val Val Ser Gln Ile Ile Asp Lys Leu Lys His Ile Asn Gln Leu Leu 
                485                 490                 495     


Arg Thr Met Ser Met Pro Lys Gly Arg Val Leu Asp Lys Asn Leu Asp 
            500                 505                 510         


Glu Glu Gly Phe Glu Ser Gly Asp Cys Gly Asp Asp Glu Asp Glu Cys 
        515                 520                 525             


Ile Gly Gly Ser Gly Asp Gly Met Ile Lys Val Lys Asn Gln Leu Arg 
    530                 535                 540                 


Phe Leu Ala Glu Leu Ala Tyr Asp Leu Asp Val Asp Asp Ala Pro Gly 
545                 550                 555                 560 


Asn Ser Gln Gln Ala Thr Pro Lys Asp Asn Glu Ile Ser Thr Phe His 
                565                 570                 575     


Asn Leu Gly Asn Val His Ser Pro Leu Lys Leu Leu Thr Ser Met Ala 
            580                 585                 590         


Ile Ser Val Val Cys Phe Phe Phe Leu Val His 
        595                 600             


<210>  217
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Glu Ala Phe Glu Ile Val 
    50                  55                  60                  


Val Arg His Ala Lys Asn Tyr Thr Asn Ala Met Phe Lys Asn Asn Tyr 
65                  70                  75                  80  


Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe Val Gly Glu Phe Phe Thr 
                85                  90                  95      


Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp Ile Asn Val Asp Asp Met 
            100                 105                 110         


Val Asn Glu Leu Phe Asp Ser Leu Phe Pro Val Ile Tyr Thr Gln Leu 
        115                 120                 125             


Met Asn Pro Gly Leu Pro Asp Ser Ala Leu Asp Ile Asn Glu Cys Leu 
    130                 135                 140                 


Arg Gly Ala Arg Arg Asp Leu Lys Val Phe Gly Asn Phe Pro Lys Leu 
145                 150                 155                 160 


Ile Met Thr Gln Val Ser Lys Ser Leu Gln Val Thr Arg Ile Phe Leu 
                165                 170                 175     


Gln Ala Leu Asn Leu Gly Ile Glu Val Ile Asn Thr Thr Asp His Leu 
            180                 185                 190         


Lys Phe Ser Lys Asp Cys Gly Arg Met Leu Thr Arg Met Trp Tyr Cys 
        195                 200                 205             


Ser Tyr Cys Gln Gly Leu Met Met Val Lys Pro Cys Gly Gly Tyr Cys 
    210                 215                 220                 


Asn Val Val Met Gln Gly Cys Met Ala Gly Val Val Glu Ile Asp Lys 
225                 230                 235                 240 


Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu Glu Leu Val Asn Gly Met 
                245                 250                 255     


Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu Leu Gly Leu Phe Ser Thr 
            260                 265                 270         


Ile His Asp Ser Ile Gln Tyr Val Gln Lys Asn Ala Gly Lys Leu Thr 
        275                 280                 285             


Thr Thr Ile Gly Lys Leu Cys Ala His Ser Gln Gln Arg Gln Tyr Arg 
    290                 295                 300                 


Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile Asp Lys Lys Val Leu Lys 
305                 310                 315                 320 


Val Ala His Val Glu His Glu Glu Thr Leu Ser Ser Arg Arg Arg Glu 
                325                 330                 335     


Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser Phe Tyr Ser Ala Leu Pro 
            340                 345                 350         


Gly Tyr Ile Cys Ser His Ser Pro Val Ala Glu Asn Asp Thr Leu Cys 
        355                 360                 365             


Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr Ser Gln Lys Ala Ala Arg 
    370                 375                 380                 


Asn Gly Met Lys Asn Gln Phe Asn Leu His Glu Leu Lys Met Lys Gly 
385                 390                 395                 400 


Pro Glu Pro Val Val Ser Gln Ile Ile Asp Lys Leu Lys His Ile Asn 
                405                 410                 415     


Gln Leu Leu Arg Thr Met Ser Met Pro Lys Gly Arg Val Leu Asp Lys 
            420                 425                 430         


Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly Asp Cys Gly Asp Asp Glu 
        435                 440                 445             


Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly Met Ile Lys Val Lys Asn 
    450                 455                 460                 


Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr Asp Leu Asp Val Asp Asp 
465                 470                 475                 480 


Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro Lys Asp Asn Glu Ile Ser 
                485                 490                 495     


Thr Phe His Asn Leu Gly Asn Val His Ser Pro Leu Lys Leu Leu Thr 
            500                 505                 510         


Ser Met Ala Ile Ser Val Val Cys Phe Phe Phe Leu Val His 
        515                 520                 525     


<210>  218
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
            340                 345                 350         


Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
        355                 360                 365             


Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
    370                 375                 380                 


Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
385                 390                 395                 400 


Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                405                 410                 415     


Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
            420                 425                 430         


Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
        435                 440                 445             


Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
    450                 455                 460                 


Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
465                 470                 475                 480 


Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                485                 490                 495     


Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
            500                 505                 510         


Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
        515                 520                 525             


Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
    530                 535                 540                 


Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
545                 550                 555                 560 


Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                565                 570                 575     


Phe Leu Val His 
            580 


<210>  219
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Thr Asp Leu Glu Gly Cys Phe Glu Cys Cys Ile Lys Cys Leu Gly 
1               5                   10                  15      


Gly Ile Pro Tyr Ala Ser Leu Ile Ala Thr Ile Leu Leu Tyr Ala Gly 
            20                  25                  30          


Val Ala Leu Phe Cys Gly Cys Gly His Glu Ala Leu Ser Gly Thr Val 
        35                  40                  45              


Asn Ile Leu Gln Thr Tyr Phe Glu Met Ala Arg Thr Ala Gly Asp Thr 
    50                  55                  60                  


Leu Asp Val Phe Thr Met Ile Asp Ile Phe Lys Tyr Val Ile Tyr Gly 
65                  70                  75                  80  


Ile Ala Ala Ala Phe Phe Val Tyr Gly Ile Leu Leu Met Val Glu Gly 
                85                  90                  95      


Phe Phe Thr Thr Gly Ala Ile Lys Asp Leu Tyr Gly Asp Phe Lys Ile 
            100                 105                 110         


Thr Thr Cys Gly Arg Cys Val Ser Ala Trp Phe Ile Met Leu Thr Tyr 
        115                 120                 125             


Leu Phe Met Leu Ala Trp Leu Gly Val Thr Ala Phe Thr Ser Leu Pro 
    130                 135                 140                 


Val Tyr Met Tyr Phe Asn Leu Trp Thr Ile Cys Arg Asn Thr Thr Leu 
145                 150                 155                 160 


Val Glu Gly Ala Asn Leu Cys Leu Asp Leu Arg Gln Phe Gly Ile Val 
                165                 170                 175     


Thr Ile Gly Glu Glu Lys Lys Ile Cys Thr Val Ser Glu Asn Phe Leu 
            180                 185                 190         


Arg Met Cys Glu Ser Thr Glu Leu Asn Met Thr Phe His Leu Phe Ile 
        195                 200                 205             


Val Ala Leu Ala Gly Ala Gly Ala Ala Val Ile Ala Met Val His Tyr 
    210                 215                 220                 


Leu Met Val Leu Ser Ala Asn Trp Ala Tyr Val Lys Asp Ala Cys Arg 
225                 230                 235                 240 


Met Gln Lys Tyr Glu Asp Ile Lys Ser Lys Glu Glu Gln Glu Leu His 
                245                 250                 255     


Asp Ile His Ser Thr Arg Ser Lys Glu Arg Leu Asn Ala Tyr Thr 
            260                 265                 270     


<210>  220
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Glu Glu Asn Met Glu Glu Gly Gln Thr Gln Lys Gly Cys Phe Glu 
1               5                   10                  15      


Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr Ala Ser Leu Ile Ala 
            20                  25                  30          


Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe Cys Gly Cys Gly His 
        35                  40                  45              


Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln Thr Tyr Phe Glu Met 
    50                  55                  60                  


Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr Met Ile Asp Ile 
65                  70                  75                  80  


Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala Phe Phe Val Tyr Gly 
                85                  90                  95      


Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp 
            100                 105                 110         


Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala 
        115                 120                 125             


Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val 
    130                 135                 140                 


Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr 
145                 150                 155                 160 


Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp 
                165                 170                 175     


Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys 
            180                 185                 190         


Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn 
        195                 200                 205             


Met Thr Phe His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala 
    210                 215                 220                 


Val Ile Ala Met Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala 
225                 230                 235                 240 


Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser 
                245                 250                 255     


Lys Glu Glu Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu 
            260                 265                 270         


Arg Leu Asn Ala Tyr Thr 
        275             


<210>  221
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Glu Glu Asn Met Glu Glu Gly Gln Thr Gln Lys Gly Cys Phe Glu 
1               5                   10                  15      


Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr Ala Ser Leu Ile Ala 
            20                  25                  30          


Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe Cys Gly Cys Gly His 
        35                  40                  45              


Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln Thr Tyr Phe Glu Met 
    50                  55                  60                  


Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr Met Ile Asp Ile 
65                  70                  75                  80  


Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala Phe Phe Val Tyr Gly 
                85                  90                  95      


Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp 
            100                 105                 110         


Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala 
        115                 120                 125             


Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val 
    130                 135                 140                 


Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr 
145                 150                 155                 160 


Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp 
                165                 170                 175     


Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys 
            180                 185                 190         


Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn 
        195                 200                 205             


Met Thr Phe His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala 
    210                 215                 220                 


Val Ile Ala Met Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala 
225                 230                 235                 240 


Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser 
                245                 250                 255     


Lys Glu Glu Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu 
            260                 265                 270         


Arg Leu Asn Ala Tyr Thr 
        275             


<210>  222
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Gly Cys Phe Glu Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr 
1               5                   10                  15      


Ala Ser Leu Ile Ala Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln 
        35                  40                  45              


Thr Tyr Phe Glu Met Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe 
    50                  55                  60                  


Thr Met Ile Asp Ile Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala 
65                  70                  75                  80  


Phe Phe Val Tyr Gly Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr 
                85                  90                  95      


Gly Ala Ile Lys Asp Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly 
            100                 105                 110         


Arg Cys Val Ser Ala Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu 
        115                 120                 125             


Ala Trp Leu Gly Val Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr 
    130                 135                 140                 


Phe Asn Leu Trp Thr Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala 
145                 150                 155                 160 


Asn Leu Cys Leu Asp Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu 
                165                 170                 175     


Glu Lys Lys Ile Cys Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu 
            180                 185                 190         


Ser Thr Glu Leu Asn Met Thr Phe His Leu Phe Ile Val Ala Leu Ala 
        195                 200                 205             


Gly Ala Gly Ala Ala Val Ile Ala Met Val His Tyr Leu Met Val Leu 
    210                 215                 220                 


Ser Ala Asn Trp Ala Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr 
225                 230                 235                 240 


Glu Asp Ile Lys Ser Lys Glu Glu Gln Glu Leu His Asp Ile His Ser 
                245                 250                 255     


Thr Arg Ser Lys Glu Arg Leu Asn Ala Tyr Thr 
            260                 265         


<210>  223
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Gly Cys Phe Glu Cys Cys Ile Lys Cys Leu Gly Gly Val Pro Tyr 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Ile Leu Cys Phe Ser Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Val Ala Leu Ala Gly Thr Val Ala Ile Leu Glu 
        35                  40                  45              


Gln His Phe Ser Thr Asn Ala Ser Asp His Ala Leu Leu Ser Glu Val 
    50                  55                  60                  


Ile Gln Leu Met Gln Tyr Val Ile Tyr Gly Ile Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ile Ile Leu Leu Ala Glu Gly Phe Tyr Thr Thr Ser Ala 
                85                  90                  95      


Val Lys Glu Leu His Gly Glu Phe Lys Thr Thr Ala Cys Gly Arg Cys 
            100                 105                 110         


Ile Ser Gly Met Phe Val Phe Leu Thr Tyr Val Leu Gly Val Ala Trp 
        115                 120                 125             


Leu Gly Val Phe Gly Phe Ser Ala Val Pro Val Phe Met Phe Tyr Asn 
    130                 135                 140                 


Ile Trp Ser Thr Cys Glu Val Ile Lys Ser Pro Gln Thr Asn Gly Thr 
145                 150                 155                 160 


Thr Gly Val Glu Gln Ile Cys Val Asp Ile Arg Gln Tyr Gly Ile Ile 
                165                 170                 175     


Pro Trp Asn Ala Phe Pro Gly Lys Ile Cys Gly Ser Ala Leu Glu Asn 
            180                 185                 190         


Ile Cys Asn Thr Asn Glu Phe Tyr Met Ser Tyr His Leu Phe Ile Val 
        195                 200                 205             


Ala Cys Ala Gly Ala Gly Ala Thr Val Ile Ala Leu Leu Ile Tyr Met 
    210                 215                 220                 


Met Ala Thr Thr Tyr Asn Tyr Ala Val Leu Lys Phe Lys Ser Arg Glu 
225                 230                 235                 240 


Asp Cys Cys Thr Lys Phe 
                245     


<210>  224
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Lys Pro Ala Met Glu Thr Ala Ala Glu Glu Asn Thr Glu Gln Ser 
1               5                   10                  15      


Gln Glu Arg Lys Val Asn Ser Arg Ala Glu Met Glu Ile Gly Arg Tyr 
            20                  25                  30          


His Trp Met Tyr Pro Gly Ser Lys Asn His Gln Tyr His Pro Val Pro 
        35                  40                  45              


Thr Leu Gly Asp Arg Ala Ser Pro Leu Ser Ser Pro Gly Cys Phe Glu 
    50                  55                  60                  


Cys Cys Ile Lys Cys Leu Gly Gly Val Pro Tyr Ala Ser Leu Val Ala 
65                  70                  75                  80  


Thr Ile Leu Cys Phe Ser Gly Val Ala Leu Phe Cys Gly Cys Gly His 
                85                  90                  95      


Val Ala Leu Ala Gly Thr Val Ala Ile Leu Glu Gln His Phe Ser Thr 
            100                 105                 110         


Asn Ala Ser Asp His Ala Leu Leu Ser Glu Val Ile Gln Leu Met Gln 
        115                 120                 125             


Tyr Val Ile Tyr Gly Ile Ala Ser Phe Phe Phe Leu Tyr Gly Ile Ile 
    130                 135                 140                 


Leu Leu Ala Glu Gly Phe Tyr Thr Thr Ser Ala Val Lys Glu Leu His 
145                 150                 155                 160 


Gly Glu Phe Lys Thr Thr Ala Cys Gly Arg Cys Ile Ser Gly Met Phe 
                165                 170                 175     


Val Phe Leu Thr Tyr Val Leu Gly Val Ala Trp Leu Gly Val Phe Gly 
            180                 185                 190         


Phe Ser Ala Val Pro Val Phe Met Phe Tyr Asn Ile Trp Ser Thr Cys 
        195                 200                 205             


Glu Val Ile Lys Ser Pro Gln Thr Asn Gly Thr Thr Gly Val Glu Gln 
    210                 215                 220                 


Ile Cys Val Asp Ile Arg Gln Tyr Gly Ile Ile Pro Trp Asn Ala Phe 
225                 230                 235                 240 


Pro Gly Lys Ile Cys Gly Ser Ala Leu Glu Asn Ile Cys Asn Thr Asn 
                245                 250                 255     


Glu Phe Tyr Met Ser Tyr His Leu Phe Ile Val Ala Cys Ala Gly Ala 
            260                 265                 270         


Gly Ala Thr Val Ile Ala Leu Ile His Phe Leu Met Ile Leu Ser Ser 
        275                 280                 285             


Asn Trp Ala Tyr Leu Lys Asp Ala Ser Lys Met Gln Ala Tyr Gln Asp 
    290                 295                 300                 


Ile Lys Ala Lys Glu Glu Gln Glu Leu Gln Asp Ile Gln Ser Arg Ser 
305                 310                 315                 320 


Lys Glu Gln Leu Asn Ser Tyr Thr 
                325             


<210>  225
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Lys Pro Ala Met Glu Thr Ala Ala Glu Glu Asn Thr Glu Gln Ser 
1               5                   10                  15      


Gln Glu Arg Lys Val Asn Ser Arg Ala Glu Met Glu Ile Gly Arg Tyr 
            20                  25                  30          


His Trp Met Tyr Pro Gly Ser Lys Asn His Gln Tyr His Pro Val Pro 
        35                  40                  45              


Thr Leu Gly Asp Arg Ala Ser Pro Leu Ser Ser Pro Gly Cys Phe Glu 
    50                  55                  60                  


Cys Cys Ile Lys Cys Leu Gly Gly Val Pro Tyr Ala Ser Leu Val Ala 
65                  70                  75                  80  


Thr Ile Leu Cys Phe Ser Gly Val Ala Leu Phe Cys Gly Cys Gly His 
                85                  90                  95      


Val Ala Leu Ala Gly Thr Val Ala Ile Leu Glu Gln His Phe Ser Thr 
            100                 105                 110         


Asn Ala Ser Asp His Ala Leu Leu Ser Glu Val Ile Gln Leu Met Gln 
        115                 120                 125             


Tyr Val Ile Tyr Gly Ile Ala Ser Phe Phe Phe Leu Tyr Gly Ile Ile 
    130                 135                 140                 


Leu Leu Ala Glu Gly Phe Tyr Thr Thr Ser Ala Val Lys Glu Leu His 
145                 150                 155                 160 


Gly Glu Phe Lys Thr Thr Ala Cys Gly Arg Cys Ile Ser Gly Met Phe 
                165                 170                 175     


Val Phe Leu Thr Tyr Val Leu Gly Val Ala Trp Leu Gly Val Phe Gly 
            180                 185                 190         


Phe Ser Ala Val Pro Val Phe Met Phe Tyr Asn Ile Trp Ser Thr Cys 
        195                 200                 205             


Glu Val Ile Lys Ser Pro Gln Thr Asn Gly Thr Thr Gly Val Glu Gln 
    210                 215                 220                 


Ile Cys Val Asp Ile Arg Gln Tyr Gly Ile Ile Pro Trp Asn Ala Phe 
225                 230                 235                 240 


Pro Gly Lys Ile Cys Gly Ser Ala Leu Glu Asn Ile Cys Asn Thr Asn 
                245                 250                 255     


Glu Phe Tyr Met Ser Tyr His Leu Phe Ile Val Ala Cys Ala Gly Ala 
            260                 265                 270         


Gly Ala Thr Val Ile Ala Leu Leu Ile Tyr Met Met Ala Thr Thr Tyr 
        275                 280                 285             


Asn Tyr Ala Val Leu Lys Phe Lys Ser Arg Glu Asp Cys Cys Thr Lys 
    290                 295                 300                 


Phe 
305 


<210>  226
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Lys Pro Ala Met Glu Thr Ala Ala Glu Glu Asn Thr Glu Gln Ser 
1               5                   10                  15      


Gln Glu Arg Lys Gly Cys Phe Glu Cys Cys Ile Lys Cys Leu Gly Gly 
            20                  25                  30          


Val Pro Tyr Ala Ser Leu Val Ala Thr Ile Leu Cys Phe Ser Gly Val 
        35                  40                  45              


Ala Leu Phe Cys Gly Cys Gly His Val Ala Leu Ala Gly Thr Val Ala 
    50                  55                  60                  


Ile Leu Glu Gln His Phe Ser Thr Asn Ala Ser Asp His Ala Leu Leu 
65                  70                  75                  80  


Ser Glu Val Ile Gln Leu Met Gln Tyr Val Ile Tyr Gly Ile Ala Ser 
                85                  90                  95      


Phe Phe Phe Leu Tyr Gly Ile Ile Leu Leu Ala Glu Gly Phe Tyr Thr 
            100                 105                 110         


Thr Ser Ala Val Lys Glu Leu His Gly Glu Phe Lys Thr Thr Ala Cys 
        115                 120                 125             


Gly Arg Cys Ile Ser Gly Met Phe Val Phe Leu Thr Tyr Val Leu Gly 
    130                 135                 140                 


Val Ala Trp Leu Gly Val Phe Gly Phe Ser Ala Val Pro Val Phe Met 
145                 150                 155                 160 


Phe Tyr Asn Ile Trp Ser Thr Cys Glu Val Ile Lys Ser Pro Gln Thr 
                165                 170                 175     


Asn Gly Thr Thr Gly Val Glu Gln Ile Cys Val Asp Ile Arg Gln Tyr 
            180                 185                 190         


Gly Ile Ile Pro Trp Asn Ala Phe Pro Gly Lys Ile Cys Gly Ser Ala 
        195                 200                 205             


Leu Glu Asn Ile Cys Asn Thr Asn Glu Phe Tyr Met Ser Tyr His Leu 
    210                 215                 220                 


Phe Ile Val Ala Cys Ala Gly Ala Gly Ala Thr Val Ile Ala Leu Leu 
225                 230                 235                 240 


Ile Tyr Met Met Ala Thr Thr Tyr Asn Tyr Ala Val Leu Lys Phe Lys 
                245                 250                 255     


Ser Arg Glu Asp Cys Cys Thr Lys Phe 
            260                 265 


<210>  227
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Val Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  228
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Val Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  229
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Val Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  230
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Val Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  231
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Val Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  232
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Val Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  233
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Val Phe Ala His Arg Met Asp Asn Ser Lys Pro His Leu Ile Ile 
1               5                   10                  15      


Pro Thr Leu Leu Val Pro Leu Gln Asn Arg Ser Cys Thr Glu Thr Ala 
            20                  25                  30          


Thr Pro Leu Pro Ser Gln Tyr Leu Met Glu Leu Ser Glu Glu His Ser 
        35                  40                  45              


Trp Met Ser Asn Gln Thr Asp Leu His Tyr Val Leu Lys Pro Gly Glu 
    50                  55                  60                  


Val Ala Thr Ala Ser Ile Phe Phe Gly Ile Leu Trp Leu Phe Ser Ile 
65                  70                  75                  80  


Phe Gly Asn Ser Leu Val Cys Leu Val Ile His Arg Ser Arg Arg Thr 
                85                  90                  95      


Gln Ser Thr Thr Asn Tyr Phe Val Val Ser Met Ala Cys Ala Asp Leu 
            100                 105                 110         


Leu Ile Ser Val Ala Ser Thr Pro Phe Val Leu Leu Gln Phe Thr Thr 
        115                 120                 125             


Gly Arg Trp Thr Leu Gly Ser Ala Thr Cys Lys Val Val Arg Tyr Phe 
    130                 135                 140                 


Gln Tyr Leu Thr Pro Gly Val Gln Ile Tyr Val Leu Leu Ser Ile Cys 
145                 150                 155                 160 


Ile Asp Arg Phe Tyr Thr Ile Val Tyr Pro Leu Ser Phe Lys Val Ser 
                165                 170                 175     


Arg Glu Lys Ala Lys Lys Met Ile Ala Ala Ser Trp Ile Phe Asp Ala 
            180                 185                 190         


Gly Phe Val Thr Pro Val Leu Phe Phe Tyr Gly Ser Asn Trp Asp Ser 
        195                 200                 205             


His Cys Asn Tyr Phe Leu Pro Ser Ser Trp Glu Gly Thr Ala Tyr Thr 
    210                 215                 220                 


Val Ile His Phe Leu Val Gly Phe Val Ile Pro Ser Val Leu Ile Ile 
225                 230                 235                 240 


Leu Phe Tyr Gln Lys Val Ile Lys Tyr Ile Trp Arg Ile Gly Thr Asp 
                245                 250                 255     


Gly Arg Thr Val Arg Arg Thr Met Asn Ile Val Pro Arg Thr Lys Val 
            260                 265                 270         


Lys Thr Ile Lys Met Phe Leu Ile Leu Asn Leu Leu Phe Leu Leu Ser 
        275                 280                 285             


Trp Leu Pro Phe His Val Ala Gln Leu Trp His Pro His Glu Gln Asp 
    290                 295                 300                 


Tyr Lys Lys Ser Ser Leu Val Phe Thr Ala Ile Thr Trp Ile Ser Phe 
305                 310                 315                 320 


Ser Ser Ser Ala Ser Lys Pro Thr Leu Tyr Ser Ile Tyr Asn Ala Asn 
                325                 330                 335     


Phe Arg Arg Gly Met Lys Glu Thr Phe Cys Met Ser Ser Met Lys Cys 
            340                 345                 350         


Tyr Arg Ser Asn Ala Tyr Thr Ile Thr Thr Ser Ser Arg Met Ala Lys 
        355                 360                 365             


Lys Asn Tyr Val Gly Ile Ser Glu Ile Pro Ser Met Ala Lys Thr Ile 
    370                 375                 380                 


Thr Lys Asp Ser Ile Tyr Asp Ser Phe Asp Arg Glu Ala Lys Glu Lys 
385                 390                 395                 400 


Lys Leu Ala Trp Pro Ile Asn Ser Asn Pro Pro Asn Thr Phe Val 
                405                 410                 415 


<210>  234
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Thr Asn Ser Ser Ser Thr Ser Thr Ser Ser Thr Thr Gly Gly Ser 
1               5                   10                  15      


Leu Leu Leu Leu Cys Glu Glu Glu Glu Ser Trp Ala Gly Arg Arg Ile 
            20                  25                  30          


Pro Val Ser Leu Leu Tyr Ser Gly Leu Ala Ile Gly Gly Thr Leu Ala 
        35                  40                  45              


Asn Gly Met Val Ile Tyr Leu Val Ser Ser Phe Arg Lys Leu Gln Thr 
    50                  55                  60                  


Thr Ser Asn Ala Phe Ile Val Asn Gly Cys Ala Ala Asp Leu Ser Val 
65                  70                  75                  80  


Cys Ala Leu Trp Met Pro Gln Glu Ala Val Leu Gly Leu Leu Pro Thr 
                85                  90                  95      


Gly Ser Ala Glu Pro Pro Ala Asp Trp Asp Gly Ala Gly Gly Ser Tyr 
            100                 105                 110         


Arg Leu Leu Arg Gly Gly Leu Leu Gly Leu Gly Leu Thr Val Ser Leu 
        115                 120                 125             


Leu Ser His Cys Leu Val Ala Leu Asn Arg Tyr Leu Leu Ile Thr Arg 
    130                 135                 140                 


Ala Pro Ala Thr Tyr Gln Ala Leu Tyr Gln Arg Arg His Thr Ala Gly 
145                 150                 155                 160 


Met Leu Ala Leu Ser Trp Ala Leu Ala Leu Gly Leu Val Leu Leu Leu 
                165                 170                 175     


Pro Pro Trp Ala Pro Arg Pro Gly Ala Ala Pro Pro Arg Val His Tyr 
            180                 185                 190         


Pro Ala Leu Leu Ala Ala Ala Ala Leu Leu Ala Gln Thr Ala Leu Leu 
        195                 200                 205             


Leu His Cys Tyr Leu Gly Ile Val Arg Arg Val Arg Val Ser Val Lys 
    210                 215                 220                 


Arg Val Ser Val Leu Asn Phe His Leu Leu His Gln Leu Pro Gly Cys 
225                 230                 235                 240 


Ala Ala Ala Ala Ala Ala Phe Pro Gly Ala Gln His Ala Pro Gly Pro 
                245                 250                 255     


Gly Gly Ala Ala His Pro Ala Gln Ala Gln Pro Leu Pro Pro Ala Leu 
            260                 265                 270         


His Pro Arg Arg Ala Gln Arg Arg Leu Ser Gly Leu Ser Val Leu Leu 
        275                 280                 285             


Leu Cys Cys Val Phe Leu Leu Ala Thr Gln Pro Leu Val Trp Val Ser 
    290                 295                 300                 


Leu Ala Ser Gly Phe Ser Leu Pro Val Pro Trp Gly Val Gln Ala Ala 
305                 310                 315                 320 


Ser Trp Leu Leu Cys Cys Ala Leu Ser Ala Leu Asn Pro Leu Leu Tyr 
                325                 330                 335     


Thr Trp Arg Asn Glu Glu Phe Arg Arg Ser Val Arg Ser Val Leu Pro 
            340                 345                 350         


Gly Val Gly Asp Ala Ala Ala Ala Ala Val Ala Ala Thr Ala Val Pro 
        355                 360                 365             


Ala Val Ser Gln Ala Gln Leu Gly Thr Arg Ala Ala Gly Gln His Trp 
    370                 375                 380                 


<210>  235
<211>  981
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Pro Ala Glu Leu Leu Leu Leu Leu Ile Val Ala Phe Ala Ser Pro 
1               5                   10                  15      


Ser Cys Gln Val Leu Ser Ser Leu Arg Met Ala Ala Ile Leu Asp Asp 
            20                  25                  30          


Gln Thr Val Cys Gly Arg Gly Glu Arg Leu Ala Leu Ala Leu Ala Arg 
        35                  40                  45              


Glu Gln Ile Asn Gly Ile Ile Glu Val Pro Ala Lys Ala Arg Val Glu 
    50                  55                  60                  


Val Asp Ile Phe Glu Leu Gln Arg Asp Ser Gln Tyr Glu Thr Thr Asp 
65                  70                  75                  80  


Thr Met Cys Gln Ile Leu Pro Lys Gly Val Val Ser Val Leu Gly Pro 
                85                  90                  95      


Ser Ser Ser Pro Ala Ser Ala Ser Thr Val Ser His Ile Cys Gly Glu 
            100                 105                 110         


Lys Glu Ile Pro His Ile Lys Val Gly Pro Glu Glu Thr Pro Arg Leu 
        115                 120                 125             


Gln Tyr Leu Arg Phe Ala Ser Val Ser Leu Tyr Pro Ser Asn Glu Asp 
    130                 135                 140                 


Val Ser Leu Ala Val Ser Arg Ile Leu Lys Ser Phe Asn Tyr Pro Ser 
145                 150                 155                 160 


Ala Ser Leu Ile Cys Ala Lys Ala Glu Cys Leu Leu Arg Leu Glu Glu 
                165                 170                 175     


Leu Val Arg Gly Phe Leu Ile Ser Lys Glu Thr Leu Ser Val Arg Met 
            180                 185                 190         


Leu Asp Asp Ser Arg Asp Pro Thr Pro Leu Leu Lys Glu Ile Arg Asp 
        195                 200                 205             


Asp Lys Val Ser Thr Ile Ile Ile Asp Ala Asn Ala Ser Ile Ser His 
    210                 215                 220                 


Leu Ile Leu Arg Lys Ala Ser Glu Leu Gly Met Thr Ser Ala Phe Tyr 
225                 230                 235                 240 


Lys Tyr Ile Leu Thr Thr Met Asp Phe Pro Ile Leu His Leu Asp Gly 
                245                 250                 255     


Ile Val Glu Asp Ser Ser Asn Ile Leu Gly Phe Ser Met Phe Asn Thr 
            260                 265                 270         


Ser His Pro Phe Tyr Pro Glu Phe Val Arg Ser Leu Asn Met Ser Trp 
        275                 280                 285             


Arg Glu Asn Cys Glu Ala Ser Thr Tyr Leu Gly Pro Ala Leu Ser Ala 
    290                 295                 300                 


Ala Leu Met Phe Asp Ala Val His Val Val Val Ser Ala Val Arg Glu 
305                 310                 315                 320 


Leu Asn Arg Ser Gln Glu Ile Gly Val Lys Pro Leu Ala Cys Thr Ser 
                325                 330                 335     


Ala Asn Ile Trp Pro His Gly Thr Ser Leu Met Asn Tyr Leu Arg Met 
            340                 345                 350         


Val Glu Tyr Asp Gly Leu Thr Gly Arg Val Glu Phe Asn Ser Lys Gly 
        355                 360                 365             


Gln Arg Thr Asn Tyr Thr Leu Arg Ile Leu Glu Lys Ser Arg Gln Gly 
    370                 375                 380                 


His Arg Glu Ile Gly Val Trp Tyr Ser Asn Arg Thr Leu Ala Met Asn 
385                 390                 395                 400 


Ala Thr Thr Leu Asp Ile Asn Leu Ser Gln Thr Leu Ala Asn Lys Thr 
                405                 410                 415     


Leu Val Val Thr Thr Ile Leu Glu Asn Pro Tyr Val Met Arg Arg Pro 
            420                 425                 430         


Asn Phe Gln Ala Leu Ser Gly Asn Glu Arg Phe Glu Gly Phe Cys Val 
        435                 440                 445             


Asp Met Leu Arg Glu Leu Ala Glu Leu Leu Arg Phe Arg Tyr Arg Leu 
    450                 455                 460                 


Arg Leu Val Glu Asp Gly Leu Tyr Gly Ala Pro Glu Pro Asn Gly Ser 
465                 470                 475                 480 


Trp Thr Gly Met Val Gly Glu Leu Ile Asn Arg Lys Ala Asp Leu Ala 
                485                 490                 495     


Val Ala Ala Phe Thr Ile Thr Ala Glu Arg Glu Lys Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Val His 
        515                 520                 525             


Met Gly Arg Lys Pro Gly Tyr Phe Ser Phe Leu Asp Pro Phe Ser Pro 
    530                 535                 540                 


Ala Val Trp Leu Phe Met Leu Leu Ala Tyr Leu Ala Val Ser Cys Val 
545                 550                 555                 560 


Leu Phe Leu Ala Ala Arg Leu Ser Pro Tyr Glu Trp Tyr Asn Pro His 
                565                 570                 575     


Pro Cys Leu Arg Ala Arg Pro His Ile Leu Glu Asn Gln Tyr Thr Leu 
            580                 585                 590         


Gly Asn Ser Leu Trp Phe Pro Val Gly Gly Phe Met Gln Gln Gly Ser 
        595                 600                 605             


Glu Ile Met Pro Arg Ala Leu Ser Thr Arg Cys Val Ser Gly Val Trp 
    610                 615                 620                 


Trp Ala Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
625                 630                 635                 640 


Ala Phe Leu Thr Val Gln Arg Met Glu Val Pro Val Glu Ser Ala Asp 
                645                 650                 655     


Asp Leu Ala Asp Gln Thr Asn Ile Glu Tyr Gly Thr Ile His Ala Gly 
            660                 665                 670         


Ser Thr Met Thr Phe Phe Gln Asn Ser Arg Tyr Gln Thr Tyr Gln Arg 
        675                 680                 685             


Met Trp Asn Tyr Met Gln Ser Lys Gln Pro Ser Val Phe Val Lys Ser 
    690                 695                 700                 


Thr Glu Glu Gly Ile Ala Arg Val Leu Asn Ser Arg Tyr Ala Phe Leu 
705                 710                 715                 720 


Leu Glu Ser Thr Met Asn Glu Tyr His Arg Arg Leu Asn Cys Asn Leu 
                725                 730                 735     


Thr Gln Ile Gly Gly Leu Leu Asp Thr Lys Gly Tyr Gly Ile Gly Met 
            740                 745                 750         


Pro Leu Gly Ser Pro Phe Arg Asp Glu Ile Thr Leu Ala Ile Leu Gln 
        755                 760                 765             


Leu Gln Glu Asn Asn Arg Leu Glu Ile Leu Lys Arg Lys Trp Trp Glu 
    770                 775                 780                 


Gly Gly Arg Cys Pro Lys Glu Glu Asp His Arg Ala Lys Gly Leu Gly 
785                 790                 795                 800 


Met Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ile Cys Gly Leu Ile 
                805                 810                 815     


Ile Ala Val Phe Val Ala Val Met Glu Phe Ile Trp Ser Thr Arg Arg 
            820                 825                 830         


Ser Ala Glu Ser Glu Glu Thr Pro Ala Leu His Pro Ala Ala Cys Gln 
        835                 840                 845             


Cys Ser Ala Leu Gly Pro Arg Thr Pro Leu Lys Glu Pro Ser Met Leu 
    850                 855                 860                 


Leu Val Lys Val Pro Ser Thr Arg Val Gln Val Ala Phe Ser Arg Thr 
865                 870                 875                 880 


Ser Leu Arg Gln Val Cys Pro Phe Leu Leu Gln His Gln Leu Ser Ser 
                885                 890                 895     


Leu Tyr Trp Ile Gln Ala Thr Asn Val Gln Ile Cys Cys His Phe Ser 
            900                 905                 910         


Ser Leu Lys Pro Ser Pro Asp Leu Thr Phe Pro Pro Ser His Arg Pro 
        915                 920                 925             


Leu Ser Ser Leu Leu Phe Thr Ala Leu Ala Ala Val Gly Gly Leu Pro 
    930                 935                 940                 


Asp Ala Ser Ser Phe Phe Phe Pro Pro Ile Ser Ser Cys Pro Pro Leu 
945                 950                 955                 960 


Gln Ser Gly Ile Gly Pro Cys His Ser Thr Glu Ala Thr Leu Val Thr 
                965                 970                 975     


Ser Asn Phe His Val 
            980     


<210>  236
<211>  980
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Pro Ala Glu Leu Leu Leu Leu Leu Ile Val Ala Phe Ala Ser Pro 
1               5                   10                  15      


Ser Cys Gln Val Leu Ser Ser Leu Arg Met Ala Ala Ile Leu Asp Asp 
            20                  25                  30          


Gln Thr Val Cys Gly Arg Gly Glu Arg Leu Ala Leu Ala Leu Ala Arg 
        35                  40                  45              


Glu Gln Ile Asn Gly Ile Ile Glu Val Pro Ala Lys Ala Arg Val Glu 
    50                  55                  60                  


Val Asp Ile Phe Glu Leu Gln Arg Asp Ser Gln Tyr Glu Thr Thr Asp 
65                  70                  75                  80  


Thr Met Cys Gln Ile Leu Pro Lys Gly Val Val Ser Val Leu Gly Pro 
                85                  90                  95      


Ser Ser Ser Pro Ala Ser Ala Ser Thr Val Ser His Ile Cys Gly Glu 
            100                 105                 110         


Lys Glu Ile Pro His Ile Lys Val Gly Pro Glu Glu Thr Pro Arg Leu 
        115                 120                 125             


Gln Tyr Leu Arg Phe Ala Ser Val Ser Leu Tyr Pro Ser Asn Glu Asp 
    130                 135                 140                 


Val Ser Leu Ala Val Ser Arg Ile Leu Lys Ser Phe Asn Tyr Pro Ser 
145                 150                 155                 160 


Ala Ser Leu Ile Cys Ala Lys Ala Glu Cys Leu Leu Arg Leu Glu Glu 
                165                 170                 175     


Leu Val Arg Gly Phe Leu Ile Ser Lys Glu Thr Leu Ser Val Arg Met 
            180                 185                 190         


Leu Asp Asp Ser Arg Asp Pro Thr Pro Leu Leu Lys Glu Ile Arg Asp 
        195                 200                 205             


Asp Lys Val Ser Thr Ile Ile Ile Asp Ala Asn Ala Ser Ile Ser His 
    210                 215                 220                 


Leu Ile Leu Arg Lys Ala Ser Glu Leu Gly Met Thr Ser Ala Phe Tyr 
225                 230                 235                 240 


Lys Tyr Ile Leu Thr Thr Met Asp Phe Pro Ile Leu His Leu Asp Gly 
                245                 250                 255     


Ile Val Glu Asp Ser Ser Asn Ile Leu Gly Phe Ser Met Phe Asn Thr 
            260                 265                 270         


Ser His Pro Phe Tyr Pro Glu Phe Val Arg Ser Leu Asn Met Ser Trp 
        275                 280                 285             


Arg Glu Asn Cys Glu Ala Ser Thr Tyr Leu Gly Pro Ala Leu Ser Ala 
    290                 295                 300                 


Ala Leu Met Phe Asp Ala Val His Val Val Val Ser Ala Val Arg Glu 
305                 310                 315                 320 


Leu Asn Arg Ser Gln Glu Ile Gly Val Lys Pro Leu Ala Cys Thr Ser 
                325                 330                 335     


Ala Asn Ile Trp Pro His Gly Thr Ser Leu Met Asn Tyr Leu Arg Met 
            340                 345                 350         


Val Glu Tyr Asp Gly Leu Thr Gly Arg Val Glu Phe Asn Ser Lys Gly 
        355                 360                 365             


Gln Arg Thr Asn Tyr Thr Leu Arg Ile Leu Glu Lys Ser Arg Gln Gly 
    370                 375                 380                 


His Arg Glu Ile Gly Val Trp Tyr Ser Asn Arg Thr Leu Ala Met Asn 
385                 390                 395                 400 


Ala Thr Thr Leu Asp Ile Asn Leu Ser Gln Thr Leu Ala Asn Lys Thr 
                405                 410                 415     


Leu Val Val Thr Thr Ile Leu Glu Asn Pro Tyr Val Met Arg Arg Pro 
            420                 425                 430         


Asn Phe Gln Ala Leu Ser Gly Asn Glu Arg Phe Glu Gly Phe Cys Val 
        435                 440                 445             


Asp Met Leu Arg Glu Leu Ala Glu Leu Leu Arg Phe Arg Tyr Arg Leu 
    450                 455                 460                 


Arg Leu Val Glu Asp Gly Leu Tyr Gly Ala Pro Glu Pro Asn Gly Ser 
465                 470                 475                 480 


Trp Thr Gly Met Val Gly Glu Leu Ile Asn Arg Lys Ala Asp Leu Ala 
                485                 490                 495     


Val Ala Ala Phe Thr Ile Thr Ala Glu Arg Glu Lys Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Val His 
        515                 520                 525             


Met Gly Arg Lys Pro Gly Tyr Phe Ser Phe Leu Asp Pro Phe Ser Pro 
    530                 535                 540                 


Ala Val Trp Leu Phe Met Leu Leu Ala Tyr Leu Ala Val Ser Cys Val 
545                 550                 555                 560 


Leu Phe Leu Ala Ala Arg Leu Ser Pro Tyr Glu Trp Tyr Asn Pro His 
                565                 570                 575     


Pro Cys Leu Arg Ala Arg Pro His Ile Leu Glu Asn Gln Tyr Thr Leu 
            580                 585                 590         


Gly Asn Ser Leu Trp Phe Pro Val Gly Gly Phe Met Gln Gln Gly Ser 
        595                 600                 605             


Glu Ile Met Pro Arg Ala Leu Ser Thr Arg Cys Val Ser Gly Val Trp 
    610                 615                 620                 


Trp Ala Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
625                 630                 635                 640 


Ala Phe Leu Thr Val Gln Arg Met Glu Val Pro Val Glu Ser Ala Asp 
                645                 650                 655     


Asp Leu Ala Asp Gln Thr Asn Ile Glu Tyr Gly Thr Ile His Ala Gly 
            660                 665                 670         


Ser Thr Met Thr Phe Phe Gln Asn Ser Arg Tyr Gln Thr Tyr Gln Arg 
        675                 680                 685             


Met Trp Asn Tyr Met Gln Ser Lys Gln Pro Ser Val Phe Val Lys Ser 
    690                 695                 700                 


Thr Glu Glu Gly Ile Ala Arg Val Leu Asn Ser Arg Tyr Ala Phe Leu 
705                 710                 715                 720 


Leu Glu Ser Thr Met Asn Glu Tyr His Arg Arg Leu Asn Cys Asn Leu 
                725                 730                 735     


Thr Gln Ile Gly Gly Leu Leu Asp Thr Lys Gly Tyr Gly Ile Gly Met 
            740                 745                 750         


Pro Leu Gly Ser Pro Phe Arg Asp Glu Ile Thr Leu Ala Ile Leu Gln 
        755                 760                 765             


Leu Gln Glu Asn Asn Arg Leu Glu Ile Leu Lys Arg Lys Trp Trp Glu 
    770                 775                 780                 


Gly Gly Arg Cys Pro Lys Glu Glu Asp His Arg Ala Lys Gly Leu Gly 
785                 790                 795                 800 


Met Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ile Cys Gly Leu Ile 
                805                 810                 815     


Ile Ala Val Phe Val Ala Val Met Glu Phe Ile Trp Ser Thr Arg Arg 
            820                 825                 830         


Ser Ala Glu Ser Glu Glu Val Ser Val Cys Gln Glu Met Leu Gln Glu 
        835                 840                 845             


Leu Arg His Ala Val Ser Cys Arg Lys Thr Ser Arg Ser Arg Arg Arg 
    850                 855                 860                 


Arg Arg Pro Gly Gly Pro Ser Arg Ala Leu Leu Ser Leu Arg Ala Val 
865                 870                 875                 880 


Arg Glu Met Arg Leu Ser Asn Gly Lys Leu Tyr Ser Ala Gly Ala Gly 
                885                 890                 895     


Gly Asp Ala Gly Ser Ala His Gly Gly Pro Gln Arg Leu Leu Asp Asp 
            900                 905                 910         


Pro Gly Pro Pro Ser Gly Ala Arg Pro Ala Ala Pro Thr Pro Cys Thr 
        915                 920                 925             


His Val Arg Val Cys Gln Glu Cys Arg Arg Ile Gln Ala Leu Arg Ala 
    930                 935                 940                 


Ser Gly Ala Gly Ala Pro Pro Arg Gly Leu Gly Val Pro Ala Glu Ala 
945                 950                 955                 960 


Thr Ser Pro Pro Arg Pro Arg Pro Gly Pro Ala Gly Pro Arg Glu Leu 
                965                 970                 975     


Ala Glu His Glu 
            980 


<210>  237
<211>  1381
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Ala Ser Pro Arg Ala Ser Arg Trp Pro Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Leu Pro Pro Ala Ala Pro Gly Thr Arg Asp 
            20                  25                  30          


Pro Pro Pro Ser Pro Ala Arg Arg Ala Leu Ser Leu Ala Pro Leu Ala 
        35                  40                  45              


Gly Ala Gly Leu Glu Leu Gln Leu Glu Arg Arg Pro Glu Arg Glu Pro 
    50                  55                  60                  


Pro Pro Thr Pro Pro Arg Glu Arg Arg Gly Pro Ala Thr Pro Gly Pro 
65                  70                  75                  80  


Ser Tyr Arg Ala Pro Glu Pro Gly Ala Ala Thr Gln Arg Gly Pro Ser 
                85                  90                  95      


Gly Arg Ala Pro Arg Gly Gly Ser Ala Asp Ala Ala Trp Lys His Trp 
            100                 105                 110         


Pro Glu Ser Asn Thr Glu Ala His Val Glu Asn Ile Thr Phe Tyr Gln 
        115                 120                 125             


Asn Gln Glu Asp Phe Ser Thr Val Ser Ser Lys Glu Gly Val Met Val 
    130                 135                 140                 


Gln Thr Ser Gly Lys Ser His Ala Ala Ser Asp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu Leu Ala Glu Thr Ala Asp Ala Arg Gly Arg Ser Gly Ser Ser 
                165                 170                 175     


Ser Arg Thr Asn Phe Thr Ile Leu Pro Val Gly Tyr Ser Leu Glu Ile 
            180                 185                 190         


Ala Thr Ala Leu Thr Ser Gln Ser Gly Asn Leu Ala Ser Glu Ser Leu 
        195                 200                 205             


His Leu Pro Ser Ser Ser Ser Glu Phe Asp Glu Arg Ile Ala Ala Phe 
    210                 215                 220                 


Gln Thr Lys Ser Gly Thr Ala Ser Glu Met Gly Thr Glu Arg Ala Met 
225                 230                 235                 240 


Gly Leu Ser Glu Glu Trp Thr Val His Ser Gln Glu Ala Thr Thr Ser 
                245                 250                 255     


Ala Trp Ser Pro Ser Phe Leu Pro Ala Leu Glu Met Gly Glu Leu Thr 
            260                 265                 270         


Thr Pro Ser Arg Lys Arg Asn Ser Ser Gly Pro Asp Leu Ser Trp Leu 
        275                 280                 285             


His Phe Tyr Arg Thr Ala Ala Ser Ser Pro Leu Leu Asp Leu Ser Ser 
    290                 295                 300                 


Ser Ser Glu Ser Thr Glu Lys Leu Asn Asn Ser Thr Gly Leu Gln Ser 
305                 310                 315                 320 


Ser Ser Val Ser Gln Thr Lys Thr Met His Val Ala Thr Val Phe Thr 
                325                 330                 335     


Asp Gly Gly Pro Arg Thr Leu Arg Ser Leu Thr Val Ser Leu Gly Pro 
            340                 345                 350         


Val Ser Lys Thr Glu Gly Phe Pro Lys Asp Ser Arg Ile Ala Thr Thr 
        355                 360                 365             


Ser Ser Ser Val Leu Leu Ser Pro Ser Ala Val Glu Ser Arg Arg Asn 
    370                 375                 380                 


Ser Arg Val Thr Gly Asn Pro Gly Asp Glu Glu Phe Ile Glu Pro Ser 
385                 390                 395                 400 


Thr Glu Asn Glu Phe Gly Leu Thr Ser Leu Arg Trp Gln Asn Asp Ser 
                405                 410                 415     


Pro Thr Phe Gly Glu His Gln Leu Ala Ser Ser Ser Glu Val Gln Asn 
            420                 425                 430         


Gly Ser Pro Met Ser Gln Thr Glu Thr Val Ser Arg Ser Val Ala Pro 
        435                 440                 445             


Met Arg Gly Gly Glu Ile Thr Ala His Trp Leu Leu Thr Asn Ser Thr 
    450                 455                 460                 


Thr Ser Ala Asp Val Thr Gly Ser Ser Ala Ser Tyr Pro Glu Gly Val 
465                 470                 475                 480 


Asn Ala Ser Val Leu Thr Gln Phe Ser Asp Ser Thr Val Gln Ser Gly 
                485                 490                 495     


Gly Ser His Thr Ala Leu Gly Asp Arg Ser Tyr Ser Glu Ser Ser Ser 
            500                 505                 510         


Thr Ser Ser Ser Glu Ser Leu Asn Ser Ser Ala Pro Arg Gly Glu Arg 
        515                 520                 525             


Ser Ile Ala Gly Ile Ser Tyr Gly Gln Val Arg Gly Thr Ala Ile Glu 
    530                 535                 540                 


Gln Arg Thr Ser Ser Asp His Thr Asp His Thr Tyr Leu Ser Ser Thr 
545                 550                 555                 560 


Phe Thr Lys Gly Glu Arg Ala Leu Leu Ser Ile Thr Asp Asn Ser Ser 
                565                 570                 575     


Ser Ser Asp Ile Val Glu Ser Ser Thr Ser Tyr Ile Lys Ile Ser Asn 
            580                 585                 590         


Ser Ser His Ser Glu Tyr Ser Ser Phe Phe His Ala Gln Thr Glu Arg 
        595                 600                 605             


Ser Asn Ile Ser Ser Tyr Asp Gly Glu Tyr Ala Gln Pro Ser Thr Glu 
    610                 615                 620                 


Ser Pro Val Leu His Thr Ser Asn Leu Pro Ser Tyr Thr Pro Thr Ile 
625                 630                 635                 640 


Asn Met Pro Asn Thr Ser Val Val Leu Asp Thr Asp Ala Glu Phe Val 
                645                 650                 655     


Ser Asp Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
            660                 665                 670         


Gly Pro Pro Leu Pro Leu Pro Ser Val Ser Gln Ser His His Leu Phe 
        675                 680                 685             


Ser Ser Ile Leu Pro Ser Thr Arg Ala Ser Val His Leu Leu Lys Ser 
    690                 695                 700                 


Thr Ser Asp Ala Ser Thr Pro Trp Ser Ser Ser Pro Ser Pro Leu Pro 
705                 710                 715                 720 


Val Ser Leu Thr Thr Ser Thr Ser Ala Pro Leu Ser Val Ser Gln Thr 
                725                 730                 735     


Thr Leu Pro Gln Ser Ser Ser Thr Pro Val Leu Pro Arg Ala Arg Glu 
            740                 745                 750         


Thr Pro Val Thr Ser Phe Gln Thr Ser Thr Met Thr Ser Phe Met Thr 
        755                 760                 765             


Met Leu His Ser Ser Gln Thr Ala Asp Leu Lys Ser Gln Ser Thr Pro 
    770                 775                 780                 


His Gln Glu Lys Val Ile Thr Glu Ser Lys Ser Pro Ser Leu Val Ser 
785                 790                 795                 800 


Leu Pro Thr Glu Ser Thr Lys Ala Val Thr Thr Asn Ser Pro Leu Pro 
                805                 810                 815     


Pro Ser Leu Thr Glu Ser Ser Thr Glu Gln Thr Leu Pro Ala Thr Ser 
            820                 825                 830         


Thr Asn Leu Ala Gln Met Ser Pro Thr Phe Thr Thr Thr Ile Leu Lys 
        835                 840                 845             


Thr Ser Gln Pro Leu Met Thr Thr Pro Gly Thr Leu Ser Ser Thr Ala 
    850                 855                 860                 


Ser Leu Val Thr Gly Pro Ile Ala Val Gln Thr Thr Ala Gly Lys Gln 
865                 870                 875                 880 


Leu Ser Leu Thr His Pro Glu Ile Leu Val Pro Gln Ile Ser Thr Glu 
                885                 890                 895     


Gly Gly Ile Ser Thr Glu Arg Asn Arg Val Ile Val Asp Ala Thr Thr 
            900                 905                 910         


Gly Leu Ile Pro Leu Thr Ser Val Pro Thr Ser Ala Lys Glu Met Thr 
        915                 920                 925             


Thr Lys Leu Gly Val Thr Ala Glu Tyr Ser Pro Ala Ser Arg Ser Leu 
    930                 935                 940                 


Gly Thr Ser Pro Ser Pro Gln Thr Thr Val Val Ser Thr Ala Glu Asp 
945                 950                 955                 960 


Leu Ala Pro Lys Ser Ala Thr Phe Ala Val Gln Ser Ser Thr Gln Ser 
                965                 970                 975     


Pro Thr Thr Val Ser Ser Ser Ala Ser Val Asn Ser Cys Ala Val Asn 
            980                 985                 990         


Pro Cys Leu His Asn Gly Glu Cys  Val Ala Asp Asn Thr  Ser Arg Gly 
        995                 1000                 1005             


Tyr His  Cys Arg Cys Pro Pro  Ser Trp Gln Gly Asp  Asp Cys Ser 
    1010                 1015                 1020             


Val Asp  Val Asn Glu Cys Leu  Ser Asn Pro Cys Pro  Ser Thr Ala 
    1025                 1030                 1035             


Met Cys  Asn Asn Thr Gln Gly  Ser Phe Ile Cys Lys  Cys Pro Val 
    1040                 1045                 1050             


Gly Tyr  Gln Leu Glu Lys Gly  Ile Cys Asn Leu Val  Arg Thr Phe 
    1055                 1060                 1065             


Val Thr  Glu Phe Lys Leu Lys  Arg Thr Phe Leu Asn  Thr Thr Val 
    1070                 1075                 1080             


Glu Lys  His Ser Asp Leu Gln  Glu Val Glu Asn Glu  Ile Thr Lys 
    1085                 1090                 1095             


Thr Leu  Asn Met Cys Phe Ser  Ala Leu Pro Ser Tyr  Ile Arg Ser 
    1100                 1105                 1110             


Thr Val  His Ala Ser Arg Glu  Ser Asn Ala Val Val  Ile Ser Leu 
    1115                 1120                 1125             


Gln Thr  Thr Phe Ser Leu Ala  Ser Asn Val Thr Leu  Phe Asp Leu 
    1130                 1135                 1140             


Ala Asp  Arg Met Gln Lys Cys  Val Asn Ser Cys Lys  Ser Ser Ala 
    1145                 1150                 1155             


Glu Val  Cys Gln Leu Leu Gly  Ser Gln Arg Arg Ile  Phe Arg Ala 
    1160                 1165                 1170             


Gly Ser  Leu Cys Lys Arg Lys  Ser Pro Glu Cys Asp  Lys Asp Thr 
    1175                 1180                 1185             


Ser Ile  Cys Thr Asp Leu Asp  Gly Val Ala Leu Cys  Gln Cys Lys 
    1190                 1195                 1200             


Ser Gly  Tyr Phe Gln Phe Asn  Lys Met Asp His Ser  Cys Arg Ala 
    1205                 1210                 1215             


Cys Glu  Asp Gly Tyr Arg Leu  Glu Asn Glu Thr Cys  Met Ser Cys 
    1220                 1225                 1230             


Pro Phe  Gly Leu Gly Gly Leu  Asn Cys Gly Asn Pro  Tyr Gln Leu 
    1235                 1240                 1245             


Ile Thr  Val Val Ile Ala Ala  Ala Gly Gly Gly Leu  Leu Leu Ile 
    1250                 1255                 1260             


Leu Gly  Ile Ala Leu Ile Val  Thr Cys Cys Arg Lys  Asn Lys Asn 
    1265                 1270                 1275             


Asp Ile  Ser Lys Leu Ile Phe  Lys Ser Gly Asp Phe  Gln Met Ser 
    1280                 1285                 1290             


Pro Tyr  Ala Glu Tyr Pro Lys  Asn Pro Arg Ser Gln  Glu Trp Gly 
    1295                 1300                 1305             


Arg Glu  Ala Ile Glu Met His  Glu Asn Gly Ser Thr  Lys Asn Leu 
    1310                 1315                 1320             


Leu Gln  Met Thr Asp Val Tyr  Tyr Ser Pro Thr Ser  Val Arg Asn 
    1325                 1330                 1335             


Pro Glu  Leu Glu Arg Asn Gly  Leu Tyr Pro Ala Tyr  Thr Gly Leu 
    1340                 1345                 1350             


Pro Gly  Ser Arg His Ser Cys  Ile Phe Pro Gly Gln  Tyr Asn Pro 
    1355                 1360                 1365             


Ser Phe  Ile Ser Asp Glu Ser  Arg Arg Arg Asp Tyr  Phe 
    1370                 1375                 1380     


<210>  238
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Asn Ile Thr Asn Cys Thr Thr Glu Ala Ser Met Ala Ile Arg Pro 
1               5                   10                  15      


Lys Thr Ile Thr Glu Lys Met Leu Ile Cys Met Thr Leu Val Val Ile 
            20                  25                  30          


Thr Thr Leu Thr Thr Leu Leu Asn Leu Ala Val Ile Met Ala Ile Gly 
        35                  40                  45              


Thr Thr Lys Lys Leu His Gln Pro Ala Asn Tyr Leu Ile Cys Ser Leu 
    50                  55                  60                  


Ala Val Thr Asp Leu Leu Val Ala Val Leu Val Met Pro Leu Ser Ile 
65                  70                  75                  80  


Ile Tyr Ile Val Met Asp Arg Trp Lys Leu Gly Tyr Phe Leu Cys Glu 
                85                  90                  95      


Val Trp Leu Ser Val Asp Met Thr Cys Cys Thr Cys Ser Ile Leu His 
            100                 105                 110         


Leu Cys Val Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asn Ala Ile 
        115                 120                 125             


Glu Tyr Ala Arg Lys Arg Thr Ala Lys Arg Ala Ala Leu Met Ile Leu 
    130                 135                 140                 


Thr Val Trp Thr Ile Ser Ile Phe Ile Ser Met Pro Pro Leu Phe Trp 
145                 150                 155                 160 


Arg Ser His Arg Arg Leu Ser Pro Pro Pro Ser Gln Cys Thr Ile Gln 
                165                 170                 175     


His Asp His Val Ile Tyr Thr Ile Tyr Ser Thr Leu Gly Ala Phe Tyr 
            180                 185                 190         


Ile Pro Leu Thr Leu Ile Leu Ile Leu Tyr Tyr Arg Ile Tyr His Ala 
        195                 200                 205             


Ala Lys Ser Leu Tyr Gln Lys Arg Gly Ser Ser Arg His Leu Ser Asn 
    210                 215                 220                 


Arg Ser Thr Asp Ser Gln Asn Ser Phe Ala Ser Cys Lys Leu Thr Gln 
225                 230                 235                 240 


Thr Phe Cys Val Ser Asp Phe Ser Thr Ser Asp Pro Thr Thr Glu Phe 
                245                 250                 255     


Glu Lys Phe His Ala Ser Ile Arg Ile Pro Pro Phe Asp Asn Asp Leu 
            260                 265                 270         


Asp His Pro Gly Glu Arg Gln Gln Ile Ser Ser Thr Arg Glu Arg Lys 
        275                 280                 285             


Ala Ala Arg Ile Leu Gly Leu Ile Leu Gly Ala Phe Ile Leu Ser Trp 
    290                 295                 300                 


Leu Pro Phe Phe Ile Lys Glu Leu Ile Val Gly Leu Ser Ile Tyr Thr 
305                 310                 315                 320 


Val Ser Ser Glu Val Ala Asp Phe Leu Thr Trp Leu Gly Tyr Val Asn 
                325                 330                 335     


Ser Leu Ile Asn Pro Leu Leu Tyr Thr Ser Phe Asn Glu Asp Phe Lys 
            340                 345                 350         


Leu Ala Phe Lys Lys Leu Ile Arg Cys Arg Glu His Thr 
        355                 360                 365 


<210>  239
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Ala Ala Pro Arg Ala Gly Arg Gly Ala Gly Trp Ser Leu Arg Ala 
1               5                   10                  15      


Trp Arg Ala Leu Gly Gly Ile Arg Trp Gly Arg Arg Pro Arg Leu Thr 
            20                  25                  30          


Pro Asp Leu Arg Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala 
        35                  40                  45              


Arg Val Thr Tyr Gly Thr Pro Ser Leu Trp Ala Arg Leu Ser Val Gly 
    50                  55                  60                  


Val Thr Glu Pro Arg Ala Cys Leu Thr Ser Gly Thr Pro Gly Pro Arg 
65                  70                  75                  80  


Ala Gln Leu Thr Ala Val Thr Pro Asp Thr Arg Thr Arg Glu Ala Ser 
                85                  90                  95      


Glu Asn Ser Gly Thr Arg Ser Arg Ala Trp Leu Ala Val Ala Leu Gly 
            100                 105                 110         


Ala Gly Gly Ala Val Leu Leu Leu Leu Trp Gly Gly Gly Arg Gly Pro 
        115                 120                 125             


Pro Ala Val Leu Ala Ala Val Pro Ser Pro Pro Pro Ala Ser Pro Arg 
    130                 135                 140                 


Ser Gln Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Thr Ala Pro Ala 
145                 150                 155                 160 


Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Phe Leu Gly Arg Glu 
                165                 170                 175     


Val Pro Ile Ser Asn Gly Ser Gly Phe Val Val Ala Ala Asp Gly Leu 
            180                 185                 190         


Ile Val Thr Asn Ala His Val Val Ala Asp Arg Arg Arg Val Arg Val 
        195                 200                 205             


Arg Leu Leu Ser Gly Asp Thr Tyr Glu Ala Val Val Thr Ala Val Asp 
    210                 215                 220                 


Pro Val Ala Asp Ile Ala Thr Leu Arg Ile Gln Thr Lys Glu Pro Leu 
225                 230                 235                 240 


Pro Thr Leu Pro Leu Gly Arg Ser Ala Asp Val Arg Gln Gly Glu Phe 
                245                 250                 255     


Val Val Ala Met Gly Ser Pro Phe Ala Leu Gln Asn Thr Ile Thr Ser 
            260                 265                 270         


Gly Ile Val Ser Ser Ala Gln Arg Pro Ala Arg Asp Leu Gly Leu Pro 
        275                 280                 285             


Gln Thr Asn Val Glu Tyr Ile Gln Thr Asp Ala Ala Ile Asp Phe Gly 
    290                 295                 300                 


Asn Ser Gly Gly Pro Leu Val Asn Leu Ala Arg Glu Leu Gly Ala Val 
305                 310                 315                 320 


Ser Leu Gln Asp Gly Glu Val Ile Gly Val Asn Thr Met Lys Val Thr 
                325                 330                 335     


Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp Arg Leu Arg Glu Phe Leu 
            340                 345                 350         


His Arg Gly Glu Lys Lys Asn Ser Ser Ser Gly Ile Ser Gly Ser Gln 
        355                 360                 365             


Arg Arg Tyr Ile Gly Val Met Met Leu Thr Leu Ser Pro Arg Ala Gly 
    370                 375                 380                 


Leu Arg Pro Gly Asp Val Ile Leu Ala Ile Gly Glu Gln Met Val Gln 
385                 390                 395                 400 


Asn Ala Glu Asp Val Tyr Glu Ala Val Arg Thr Gln Ser Gln Leu Ala 
                405                 410                 415     


Val Gln Ile Arg Arg Gly Arg Glu Thr Leu Thr Leu Tyr Val Thr Pro 
            420                 425                 430         


Glu Val Thr Glu 
        435     


<210>  240
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Ala Ala Pro Arg Ala Gly Arg Gly Ala Gly Trp Ser Leu Arg Ala 
1               5                   10                  15      


Trp Arg Ala Leu Gly Gly Ile Arg Trp Gly Arg Arg Pro Arg Leu Thr 
            20                  25                  30          


Pro Asp Leu Arg Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala 
        35                  40                  45              


Arg Val Thr Tyr Gly Thr Pro Ser Leu Trp Ala Arg Leu Ser Val Gly 
    50                  55                  60                  


Val Thr Glu Pro Arg Ala Cys Leu Thr Ser Gly Thr Pro Gly Pro Arg 
65                  70                  75                  80  


Ala Gln Leu Thr Ala Val Thr Pro Asp Thr Arg Thr Arg Glu Ala Ser 
                85                  90                  95      


Glu Asn Ser Gly Thr Arg Ser Arg Ala Trp Leu Ala Val Ala Leu Gly 
            100                 105                 110         


Ala Gly Gly Ala Val Leu Leu Leu Leu Trp Gly Gly Gly Arg Gly Pro 
        115                 120                 125             


Pro Ala Val Leu Ala Ala Val Pro Ser Pro Pro Pro Ala Ser Pro Arg 
    130                 135                 140                 


Ser Gln Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Thr Ala Pro Ala 
145                 150                 155                 160 


Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Phe Leu Gly Arg Glu 
                165                 170                 175     


Val Pro Ile Ser Asn Gly Ser Gly Phe Val Val Ala Ala Asp Gly Leu 
            180                 185                 190         


Ile Val Thr Asn Ala His Val Val Ala Asp Arg Arg Arg Val Arg Val 
        195                 200                 205             


Arg Leu Leu Ser Gly Asp Thr Tyr Glu Ala Val Val Thr Ala Val Asp 
    210                 215                 220                 


Pro Val Ala Asp Ile Ala Thr Leu Arg Ile Gln Thr Lys Glu Pro Leu 
225                 230                 235                 240 


Pro Thr Leu Pro Leu Gly Arg Ser Ala Asp Val Arg Gln Gly Glu Phe 
                245                 250                 255     


Val Val Ala Met Gly Ser Pro Phe Ala Leu Gln Asn Thr Ile Thr Ser 
            260                 265                 270         


Gly Ile Val Ser Ser Ala Gln Arg Pro Ala Arg Asp Leu Gly Leu Pro 
        275                 280                 285             


Gln Thr Asn Val Glu Tyr Ile Gln Thr Asp Ala Ala Ile Asp Phe Gly 
    290                 295                 300                 


Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Val 
305                 310                 315                 320 


Asn Thr Met Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp 
                325                 330                 335     


Arg Leu Arg Glu Phe Leu His Arg Gly Glu Lys Lys Asn Ser Ser Ser 
            340                 345                 350         


Gly Ile Ser Gly Ser Gln Arg Arg Tyr Ile Gly Val Met Met Leu Thr 
        355                 360                 365             


Leu Ser Pro Ser Ile Leu Ala Glu Leu Gln Leu Arg Glu Pro Ser Phe 
    370                 375                 380                 


Pro Asp Val Gln His Gly Val Leu Ile His Lys Val Ile Leu Gly Ser 
385                 390                 395                 400 


Pro Ala His Arg Ala Gly Leu Arg Pro Gly Asp Val Ile Leu Ala Ile 
                405                 410                 415     


Gly Glu Gln Met Val Gln Asn Ala Glu Asp Val Tyr Glu Ala Val Arg 
            420                 425                 430         


Thr Gln Ser Gln Leu Ala Val Gln Ile Arg Arg Gly Arg Glu Thr Leu 
        435                 440                 445             


Thr Leu Tyr Val Thr Pro Glu Val Thr Glu 
    450                 455             


<210>  241
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Ala Ala Pro Arg Ala Gly Arg Gly Ala Gly Trp Ser Leu Arg Ala 
1               5                   10                  15      


Trp Arg Ala Leu Gly Gly Ile Arg Trp Gly Arg Arg Pro Arg Leu Thr 
            20                  25                  30          


Pro Asp Leu Arg Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala 
        35                  40                  45              


Arg Val Thr Tyr Gly Thr Pro Ser Leu Trp Ala Arg Leu Ser Val Gly 
    50                  55                  60                  


Val Thr Glu Pro Arg Ala Cys Leu Thr Ser Gly Thr Pro Gly Pro Arg 
65                  70                  75                  80  


Ala Gln Leu Thr Ala Val Thr Pro Asp Thr Arg Thr Arg Glu Ala Ser 
                85                  90                  95      


Glu Asn Ser Gly Thr Arg Ser Arg Ala Trp Leu Ala Val Ala Leu Gly 
            100                 105                 110         


Ala Gly Gly Ala Val Leu Leu Leu Leu Trp Gly Gly Gly Arg Gly Pro 
        115                 120                 125             


Pro Ala Val Leu Ala Ala Val Pro Ser Pro Pro Pro Ala Ser Pro Arg 
    130                 135                 140                 


Ser Gln Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Thr Ala Pro Ala 
145                 150                 155                 160 


Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Phe Leu Gly Arg Glu 
                165                 170                 175     


Val Pro Ile Ser Asn Gly Ser Gly Phe Val Val Ala Ala Asp Gly Leu 
            180                 185                 190         


Ile Val Thr Asn Ala His Val Val Ala Asp Arg Arg Arg Val Arg Val 
        195                 200                 205             


Arg Leu Leu Ser Gly Asp Thr Tyr Glu Ala Val Val Thr Ala Val Asp 
    210                 215                 220                 


Pro Val Ala Asp Ile Ala Thr Leu Arg Ile Gln Thr Lys Phe Gly Asn 
225                 230                 235                 240 


Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Val Asn 
                245                 250                 255     


Thr Met Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp Arg 
            260                 265                 270         


Leu Arg Glu Phe Leu His Arg Gly Glu Lys Lys Asn Ser Ser Ser Gly 
        275                 280                 285             


Ile Ser Gly Ser Gln Arg Arg Tyr Ile Gly Val Met Met Leu Thr Leu 
    290                 295                 300                 


Ser Pro Arg Ala Gly Leu Arg Pro Gly Asp Val Ile Leu Ala Ile Gly 
305                 310                 315                 320 


Glu Gln Met Val Gln Asn Ala Glu Asp Val Tyr Glu Ala Val Arg Thr 
                325                 330                 335     


Gln Ser Gln Leu Ala Val Gln Ile Arg Arg Gly Arg Glu Thr Leu Thr 
            340                 345                 350         


Leu Tyr Val Thr Pro Glu Val Thr Glu 
        355                 360     


<210>  242
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg 
    50                  55                  60                  


Leu Leu Asp Glu Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp 
65                  70                  75                  80  


Pro Glu Pro Gly Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His 
                85                  90                  95      


Leu Ala Ala Arg Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr 
            100                 105                 110         


Ser Leu Arg Pro Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val 
        115                 120                 125             


Val Ala Arg Glu Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu 
    130                 135                 140                 


Ala Gln Leu Gly Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly 
145                 150                 155                 160 


Ser Ser Gly Val Cys Trp Ala 
                165         


<210>  243
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg 
    50                  55                  60                  


Leu Leu Asp Glu Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp 
65                  70                  75                  80  


Pro Glu Pro Gly Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His 
                85                  90                  95      


Leu Ala Ala Arg Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr 
            100                 105                 110         


Ser Leu Arg Pro Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val 
        115                 120                 125             


Val Ala Arg Glu Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu 
    130                 135                 140                 


Ala Gln Leu Gly Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly 
145                 150                 155                 160 


Ser Ser Gly Val Cys Trp Ala 
                165         


<210>  244
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp 
    50                  55                  60                  


His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln 
65                  70                  75                  80  


Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys 
            100                 105                 110         


Arg Glu Arg Pro Val Pro Ala Lys Gly His Cys Pro Leu Thr Pro Gly 
        115                 120                 125             


Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg Ser Ser Pro Ala Ser Ser 
    130                 135                 140                 


Ile Ala Trp Arg Thr Pro Glu Pro Val Pro Gln Gln Ala Trp Pro Asn 
145                 150                 155                 160 


Phe Leu Pro Leu Val Val Leu Val Leu Leu Leu Thr Leu Ala Val Ile 
                165                 170                 175     


Ala Ile Leu Leu Phe Ile Leu Leu Trp His Leu Cys Trp Pro Lys Glu 
            180                 185                 190         


Lys Ala Asp Pro Tyr Pro Tyr Pro Gly Leu Val Cys Gly Val Pro Asn 
        195                 200                 205             


Thr His Thr Pro Ser Ser Ser His Leu Ser Ser Pro Gly Ala Leu Glu 
    210                 215                 220                 


Thr Gly Asp Thr Trp Lys Glu Ala Ser Leu Leu Pro Leu Leu Ser Arg 
225                 230                 235                 240 


Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg Leu Leu Asp Glu 
                245                 250                 255     


Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp Pro Glu Pro Gly 
            260                 265                 270         


Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His Leu Ala Ala Arg 
        275                 280                 285             


Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr Ser Leu Arg Pro 
    290                 295                 300                 


Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val Val Ala Arg Glu 
305                 310                 315                 320 


Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu Ala Gln Leu Gly 
                325                 330                 335     


Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly Ser Ser Gly Val 
            340                 345                 350         


Cys Trp Ala 
        355 


<210>  245
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 
1               5                   10                  15      


Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 
            20                  25                  30          


Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 
        35                  40                  45              


Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 
    50                  55                  60                  


Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
65                  70                  75                  80  


Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 
                85                  90                  95      


Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 
            100                 105                 110         


Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 
        115                 120                 125             


Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 
    130                 135                 140                 


Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 
145                 150                 155                 160 


Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 
                165                 170                 175     


Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 
            180                 185                 190         


Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 
        195                 200                 205             


Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 
    210                 215                 220                 


Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 
225                 230                 235                 240 


Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 
                245                 250                 255     


Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 
            260                 265                 270         


Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 
        275                 280                 285             


Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 
    290                 295                 300                 


Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 
305                 310                 315                 320 


Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 
                325                 330                 335     


Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 
            340                 345                 350         


Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 
        355                 360                 365             


Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 
    370                 375                 380 


<210>  246
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  247
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly Glu Glu Lys Pro Gln 
        115                 120                 125             


Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr 
    130                 135                 140                 


Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr 
145                 150                 155                 160 


Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly Cys Val Phe 
                165                 170                 175     


Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp Gln Arg Arg 
            180                 185                 190         


Gln Arg Lys Ser Arg Arg Thr Ile 
        195                 200 


<210>  248
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Asp Phe Gln Ile Gln Thr 
        115                 120                 125             


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    130                 135                 140                 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
145                 150                 155                 160 


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                165                 170                 175     


<210>  249
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Gly Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu 
            20                  25                  30          


Thr Cys Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val 
        35                  40                  45              


Gly Pro Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val 
    50                  55                  60                  


Ala Asn Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala 
65                  70                  75                  80  


Gln Gly Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser 
                85                  90                  95      


Ser Gly Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala 
            100                 105                 110         


Phe Gly Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu 
        115                 120                 125             


Ile Leu Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser 
    130                 135                 140                 


Phe Met His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr 
145                 150                 155                 160 


Glu Leu Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val 
                165                 170                 175     


Arg Asp Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val 
            180                 185                 190         


Gln Ile Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser 
        195                 200                 205             


Thr Pro Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg 
    210                 215                 220                 


Ala Trp Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu 
225                 230                 235                 240 


Val Cys Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu 
                245                 250                 255     


Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln 
            260                 265                 270         


Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu 
        275                 280                 285             


Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr 
    290                 295                 300 


<210>  250
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met 
            20                  25                  30          


Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr 
        35                  40                  45              


Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn 
    50                  55                  60                  


Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn 
65                  70                  75                  80  


Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe 
                85                  90                  95      


Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys 
            100                 105                 110         


Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro 
        115                 120                 125             


Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn 
    130                 135                 140                 


Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly 
145                 150                 155                 160 


Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly 
                165                 170                 175     


Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly 
            180                 185                 190         


Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu 
        195                 200                 205             


Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met 
    210                 215                 220                 


His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu 
225                 230                 235                 240 


Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp 
                245                 250                 255     


Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile 
            260                 265                 270         


Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro 
        275                 280                 285             


Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp 
    290                 295                 300                 


Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys 
305                 310                 315                 320 


Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro 
                325                 330                 335     


Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp 
            340                 345                 350         


Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu 
        355                 360                 365             


Val Thr Glu Val Gln Val Val Gln Lys Thr 
    370                 375             


<210>  251
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Gly Ile Glu Leu Leu Cys Leu Phe Phe Leu Phe Leu Gly Arg Asn 
1               5                   10                  15      


Asp His Val Gln Gly Gly Cys Ala Leu Gly Gly Ala Glu Thr Cys Glu 
            20                  25                  30          


Asp Cys Leu Leu Ile Gly Pro Gln Cys Ala Trp Cys Ala Gln Glu Asn 
        35                  40                  45              


Phe Thr His Pro Ser Gly Val Gly Glu Arg Cys Asp Thr Pro Ala Asn 
    50                  55                  60                  


Leu Leu Ala Lys Gly Cys Gln Leu Asn Phe Ile Glu Asn Pro Val Ser 
65                  70                  75                  80  


Gln Val Glu Ile Leu Lys Asn Lys Pro Leu Ser Val Gly Arg Gln Lys 
                85                  90                  95      


Asn Ser Ser Asp Ile Val Gln Ile Ala Pro Gln Ser Leu Ile Leu Lys 
            100                 105                 110         


Leu Arg Pro Gly Gly Ala Gln Thr Leu Gln Val His Val Arg Gln Thr 
        115                 120                 125             


Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala Ser 
    130                 135                 140                 


Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu Ser 
145                 150                 155                 160 


Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser 
                165                 170                 175     


Phe Val Glu Lys Pro Val Ser Pro Phe Val Lys Thr Thr Pro Glu Glu 
            180                 185                 190         


Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr Phe Cys Leu Pro Thr Phe 
        195                 200                 205             


Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala Glu Arg Phe Asn 
    210                 215                 220                 


Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile Asp Thr Pro Glu 
225                 230                 235                 240 


Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Cys Lys Glu Lys Ile 
                245                 250                 255     


Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe Val Ser Asp Ala 
            260                 265                 270         


Asp Ser His Phe Gly Met Asp Ser Lys Leu Ala Gly Ile Val Ile Pro 
        275                 280                 285             


Asn Asp Gly Leu Cys His Leu Asp Ser Lys Asn Glu Tyr Ser Met Ser 
    290                 295                 300                 


Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln Leu Ile Asp Lys Leu Val 
305                 310                 315                 320 


Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln Val His 
                325                 330                 335     


Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val Gly Leu 
            340                 345                 350         


Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser Ala Tyr 
        355                 360                 365             


Glu Glu Leu Arg Ser Glu Val Glu Leu Glu Val Leu Gly Asp Thr Glu 
    370                 375                 380                 


Gly Leu Asn Leu Ser Phe Thr Ala Ile Cys Asn Asn Gly Thr Leu Phe 
385                 390                 395                 400 


Gln His Gln Lys Lys Cys Ser His Met Lys Val Gly Asp Thr Ala Ser 
                405                 410                 415     


Phe Ser Val Thr Val Asn Ile Pro His Cys Glu Arg Arg Ser Arg His 
            420                 425                 430         


Ile Ile Ile Lys Pro Val Gly Leu Gly Asp Ala Leu Glu Leu Leu Val 
        435                 440                 445             


Ser Pro Glu Cys Asn Cys Asp Cys Gln Lys Glu Val Glu Val Asn Ser 
    450                 455                 460                 


Ser Lys Cys His His Gly Asn Gly Ser Phe Gln Cys Gly Val Cys Ala 
465                 470                 475                 480 


Cys His Pro Gly His Met Gly Pro Arg Cys Glu Cys Gly Glu Asp Met 
                485                 490                 495     


Leu Ser Thr Asp Ser Cys Lys Glu Ala Pro Asp His Pro Ser Cys Ser 
            500                 505                 510         


Gly Arg Gly Asp Cys Tyr Cys Gly Gln Cys Ile Cys His Leu Ser Pro 
        515                 520                 525             


Tyr Gly Asn Ile Tyr Gly Pro Tyr Cys Gln Cys Asp Asn Phe Ser Cys 
    530                 535                 540                 


Val Arg His Lys Gly Leu Leu Cys Gly Gly Asn Gly Asp Cys Asp Cys 
545                 550                 555                 560 


Gly Glu Cys Val Cys Arg Ser Gly Trp Thr Gly Glu Tyr Cys Asn Cys 
                565                 570                 575     


Thr Thr Ser Thr Asp Ser Cys Val Ser Glu Asp Gly Val Leu Cys Ser 
            580                 585                 590         


Gly Arg Gly Asp Cys Val Cys Gly Lys Cys Val Cys Thr Asn Pro Gly 
        595                 600                 605             


Ala Ser Gly Pro Thr Cys Glu Arg Cys Pro Thr Cys Gly Asp Pro Cys 
    610                 615                 620                 


Asn Ser Lys Arg Ser Cys Ile Glu Cys His Leu Ser Ala Ala Gly Gln 
625                 630                 635                 640 


Ala Arg Glu Glu Cys Val Asp Lys Cys Lys Leu Ala Gly Ala Thr Ile 
                645                 650                 655     


Ser Glu Glu Glu Asp Phe Ser Lys Asp Gly Ser Val Ser Cys Ser Leu 
            660                 665                 670         


Gln Gly Glu Asn Glu Cys Leu Ile Thr Phe Leu Ile Thr Thr Asp Asn 
        675                 680                 685             


Glu Gly Lys Thr Ile Ile His Ser Ile Asn Glu Lys Asp Cys Pro Lys 
    690                 695                 700                 


Pro Pro Asn Ile Pro Met Ile Met Leu Gly Val Ser Leu Ala Ile Leu 
705                 710                 715                 720 


Leu Ile Gly Val Val Leu Leu Cys Ile Trp Lys Leu Leu Val Ser Phe 
                725                 730                 735     


His Asp Arg Lys Glu Val Ala Lys Phe Glu Ala Glu Arg Ser Lys Ala 
            740                 745                 750         


Lys Trp Gln Thr Gly Thr Asn Pro Leu Tyr Arg Gly Ser Thr Ser Thr 
        755                 760                 765             


Phe Lys Asn Val Thr Tyr Lys His Arg Glu Lys Gln Lys Val Asp Leu 
    770                 775                 780                 


Ser Thr Asp Cys 
785             


<210>  252
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Gly Ile Glu Leu Leu Cys Leu Phe Phe Leu Phe Leu Gly Arg Asn 
1               5                   10                  15      


Asp His Val Gln Gly Gly Cys Ala Leu Gly Gly Ala Glu Thr Cys Glu 
            20                  25                  30          


Asp Cys Leu Leu Ile Gly Pro Gln Cys Ala Trp Cys Ala Gln Glu Asn 
        35                  40                  45              


Phe Thr His Pro Ser Gly Val Gly Glu Arg Cys Asp Thr Pro Ala Asn 
    50                  55                  60                  


Leu Leu Ala Lys Gly Cys Gln Leu Asn Phe Ile Glu Asn Pro Val Ser 
65                  70                  75                  80  


Gln Val Glu Ile Leu Lys Asn Lys Pro Leu Ser Val Gly Arg Gln Lys 
                85                  90                  95      


Asn Ser Ser Asp Ile Val Gln Ile Ala Pro Gln Ser Leu Ile Leu Lys 
            100                 105                 110         


Leu Arg Pro Gly Gly Ala Gln Thr Leu Gln Val His Val Arg Gln Thr 
        115                 120                 125             


Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala Ser 
    130                 135                 140                 


Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu Ser 
145                 150                 155                 160 


Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser 
                165                 170                 175     


Phe Val Glu Lys Pro Val Ser Pro Phe Val Lys Thr Thr Pro Glu Glu 
            180                 185                 190         


Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr Phe Cys Leu Pro Thr Phe 
        195                 200                 205             


Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala Glu Arg Phe Asn 
    210                 215                 220                 


Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile Asp Thr Pro Glu 
225                 230                 235                 240 


Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Cys Lys Glu Lys Ile 
                245                 250                 255     


Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe Val Ser Asp Ala 
            260                 265                 270         


Asp Ser His Phe Gly Met Asp Ser Lys Leu Ala Gly Ile Val Ile Pro 
        275                 280                 285             


Asn Asp Gly Leu Cys His Leu Asp Ser Lys Asn Glu Tyr Ser Met Ser 
    290                 295                 300                 


Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln Leu Ile Asp Lys Leu Val 
305                 310                 315                 320 


Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln Val His 
                325                 330                 335     


Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val Gly Leu 
            340                 345                 350         


Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser Ala Tyr 
        355                 360                 365             


Glu Glu Leu Arg Ser Glu Val Glu Leu Glu Val Leu Gly Asp Thr Glu 
    370                 375                 380                 


Gly Leu Asn Leu Ser Phe Thr Ala Ile Cys Asn Asn Gly Thr Leu Phe 
385                 390                 395                 400 


Gln His Gln Lys Lys Cys Ser His Met Lys Val Gly Asp Thr Ala Ser 
                405                 410                 415     


Phe Ser Val Thr Val Asn Ile Pro His Cys Glu Arg Arg Ser Arg His 
            420                 425                 430         


Ile Ile Ile Lys Pro Val Gly Leu Gly Asp Ala Leu Glu Leu Leu Val 
        435                 440                 445             


Ser Pro Glu Cys Asn Cys Asp Cys Gln Lys Glu Val Glu Val Asn Ser 
    450                 455                 460                 


Ser Lys Cys His His Gly Asn Gly Ser Phe Gln Cys Gly Val Cys Ala 
465                 470                 475                 480 


Cys His Pro Gly His Met Gly Pro Arg Cys Glu Cys Gly Glu Asp Met 
                485                 490                 495     


Leu Ser Thr Asp Ser Cys Lys Glu Ala Pro Asp His Pro Ser Cys Ser 
            500                 505                 510         


Gly Arg Gly Asp Cys Tyr Cys Gly Gln Cys Ile Cys His Leu Ser Pro 
        515                 520                 525             


Tyr Gly Asn Ile Tyr Gly Pro Tyr Cys Gln Cys Asp Asn Phe Ser Cys 
    530                 535                 540                 


Val Arg His Lys Gly Leu Leu Cys Gly Gly Asn Gly Asp Cys Asp Cys 
545                 550                 555                 560 


Gly Glu Cys Val Cys Arg Ser Gly Trp Thr Gly Glu Tyr Cys Asn Cys 
                565                 570                 575     


Thr Thr Ser Thr Asp Ser Cys Val Ser Glu Asp Gly Val Leu Cys Ser 
            580                 585                 590         


Gly Arg Gly Asp Cys Val Cys Gly Lys Cys Val Cys Thr Asn Pro Gly 
        595                 600                 605             


Ala Ser Gly Pro Thr Cys Glu Arg Cys Pro Thr Cys Gly Asp Pro Cys 
    610                 615                 620                 


Asn Ser Lys Arg Ser Cys Ile Glu Cys His Leu Ser Ala Ala Gly Gln 
625                 630                 635                 640 


Ala Arg Glu Glu Cys Val Asp Lys Cys Lys Leu Ala Gly Ala Thr Ile 
                645                 650                 655     


Ser Glu Glu Glu Asp Phe Ser Lys Asp Gly Ser Val Ser Cys Ser Leu 
            660                 665                 670         


Gln Gly Glu Asn Glu Cys Leu Ile Thr Phe Leu Ile Thr Thr Asp Asn 
        675                 680                 685             


Glu Gly Lys Thr Ile Ile His Ser Ile Asn Glu Lys Asp Cys Pro Lys 
    690                 695                 700                 


Pro Pro Asn Ile Pro Met Ile Met Leu Gly Val Ser Leu Ala Ile Leu 
705                 710                 715                 720 


Leu Ile Gly Val Val Leu Leu Cys Ile Trp Lys Leu Leu Val Ser Phe 
                725                 730                 735     


His Asp Arg Lys Glu Val Ala Lys Phe Glu Ala Glu Arg Ser Lys Ala 
            740                 745                 750         


Lys Trp Gln Thr Gly Thr Asn Pro Leu Tyr Arg Gly Ser Thr Ser Thr 
        755                 760                 765             


Phe Lys Asn Val Thr Tyr Lys His Arg Glu Lys Gln Lys Val Asp Leu 
    770                 775                 780                 


Ser Thr Asp Cys 
785             


<210>  253
<211>  681
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Gly Ile Glu Leu Leu Cys Leu Phe Phe Leu Phe Leu Gly Arg Asn 
1               5                   10                  15      


Asp His Val Gln Gly Gly Cys Ala Leu Gly Gly Ala Glu Thr Cys Glu 
            20                  25                  30          


Asp Cys Leu Leu Ile Gly Pro Gln Cys Ala Trp Cys Ala Gln Glu Asn 
        35                  40                  45              


Phe Thr His Pro Ser Gly Val Gly Glu Arg Cys Asp Thr Pro Ala Asn 
    50                  55                  60                  


Leu Leu Ala Lys Gly Cys Gln Leu Asn Phe Ile Glu Asn Pro Val Ser 
65                  70                  75                  80  


Gln Val Glu Ile Leu Lys Asn Lys Pro Leu Ser Val Gly Arg Gln Lys 
                85                  90                  95      


Asn Ser Ser Asp Ile Val Gln Ile Ala Pro Gln Ser Leu Ile Leu Lys 
            100                 105                 110         


Leu Arg Pro Gly Gly Ala Gln Thr Leu Gln Val His Val Arg Gln Thr 
        115                 120                 125             


Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala Ser 
    130                 135                 140                 


Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu Ser 
145                 150                 155                 160 


Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser 
                165                 170                 175     


Phe Val Glu Lys Pro Val Ser Pro Phe Val Lys Thr Thr Pro Glu Glu 
            180                 185                 190         


Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr Phe Cys Leu Pro Thr Phe 
        195                 200                 205             


Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala Glu Arg Phe Asn 
    210                 215                 220                 


Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile Asp Thr Pro Glu 
225                 230                 235                 240 


Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Cys Lys Glu Lys Ile 
                245                 250                 255     


Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe Val Ser Asp Ala 
            260                 265                 270         


Asp Ser His Phe Gly Met Asp Ser Lys Leu Ala Gly Ile Val Ile Pro 
        275                 280                 285             


Asn Asp Gly Leu Cys His Leu Asp Ser Lys Asn Glu Tyr Ser Met Ser 
    290                 295                 300                 


Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln Leu Ile Asp Lys Leu Val 
305                 310                 315                 320 


Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln Val His 
                325                 330                 335     


Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val Gly Leu 
            340                 345                 350         


Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser Ala Tyr 
        355                 360                 365             


Glu Glu Leu Arg Ser Glu Val Glu Leu Glu Val Leu Gly Asp Thr Glu 
    370                 375                 380                 


Gly Leu Asn Leu Ser Phe Thr Ala Ile Cys Asn Asn Gly Thr Leu Phe 
385                 390                 395                 400 


Gln His Gln Lys Lys Cys Ser His Met Lys Val Gly Asp Thr Ala Ser 
                405                 410                 415     


Phe Ser Val Thr Val Asn Ile Pro His Cys Glu Arg Arg Ser Arg His 
            420                 425                 430         


Ile Ile Ile Lys Pro Val Gly Leu Gly Asp Ala Leu Glu Leu Leu Val 
        435                 440                 445             


Ser Pro Glu Cys Asn Cys Asp Cys Gln Lys Glu Val Glu Val Asn Ser 
    450                 455                 460                 


Ser Lys Cys His His Gly Asn Gly Ser Phe Gln Cys Gly Val Cys Ala 
465                 470                 475                 480 


Cys His Pro Gly His Met Gly Pro Arg Cys Glu Cys Gly Glu Asp Met 
                485                 490                 495     


Leu Ser Thr Asp Ser Cys Lys Glu Ala Pro Asp His Pro Ser Cys Ser 
            500                 505                 510         


Gly Arg Gly Asp Cys Tyr Cys Gly Gln Cys Ile Cys His Leu Ser Pro 
        515                 520                 525             


Tyr Gly Asn Ile Tyr Gly Pro Tyr Cys Gln Cys Asp Asn Phe Ser Cys 
    530                 535                 540                 


Val Arg His Lys Gly Leu Leu Cys Gly Asp Phe Ser Lys Asp Gly Ser 
545                 550                 555                 560 


Val Ser Cys Ser Leu Gln Gly Glu Asn Glu Cys Leu Ile Thr Phe Leu 
                565                 570                 575     


Ile Thr Thr Asp Asn Glu Gly Lys Thr Ile Ile His Ser Ile Asn Glu 
            580                 585                 590         


Lys Asp Cys Pro Lys Pro Pro Asn Ile Pro Met Ile Met Leu Gly Val 
        595                 600                 605             


Ser Leu Ala Ile Leu Leu Ile Gly Val Val Leu Leu Cys Ile Trp Lys 
    610                 615                 620                 


Leu Leu Val Ser Phe His Asp Arg Lys Glu Val Ala Lys Phe Glu Ala 
625                 630                 635                 640 


Glu Arg Ser Lys Ala Lys Trp Gln Thr Gly Thr Asn Pro Leu Tyr Arg 
                645                 650                 655     


Gly Ser Thr Ser Thr Phe Lys Asn Val Thr Tyr Lys His Arg Glu Lys 
            660                 665                 670         


Gln Lys Val Asp Leu Ser Thr Asp Cys 
        675                 680     


<210>  254
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Ile Thr Tyr Lys Asn Phe Thr His Pro Ser Gly Val Gly Glu Arg 
1               5                   10                  15      


Cys Asp Thr Pro Ala Asn Leu Leu Ala Lys Gly Cys Gln Leu Asn Phe 
            20                  25                  30          


Ile Glu Asn Pro Val Ser Gln Val Glu Ile Leu Lys Asn Lys Pro Leu 
        35                  40                  45              


Ser Val Gly Arg Gln Lys Asn Ser Ser Asp Ile Val Gln Ile Ala Pro 
    50                  55                  60                  


Gln Ser Leu Ile Leu Lys Leu Arg Pro Gly Gly Ala Gln Thr Leu Gln 
65                  70                  75                  80  


Val His Val Arg Gln Thr Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu 
                85                  90                  95      


Met Asp Leu Ser Ala Ser Met Asp Asp Asp Leu Asn Thr Ile Lys Glu 
            100                 105                 110         


Leu Gly Ser Arg Leu Ser Lys Glu Met Ser Lys Leu Thr Ser Asn Phe 
        115                 120                 125             


Arg Leu Gly Phe Gly Ser Phe Val Glu Lys Pro Val Ser Pro Phe Val 
    130                 135                 140                 


Lys Thr Thr Pro Glu Glu Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr 
145                 150                 155                 160 


Phe Cys Leu Pro Thr Phe Gly Phe Lys His Ile Leu Pro Leu Thr Asn 
                165                 170                 175     


Asp Ala Glu Arg Phe Asn Glu Ile Val Lys Asn Gln Lys Ile Ser Ala 
            180                 185                 190         


Asn Ile Asp Thr Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Ala 
        195                 200                 205             


Val Cys Lys Glu Lys Ile Gly Trp Arg Asn Asp Ser Leu His Leu Leu 
    210                 215                 220                 


Val Phe Val Ser Asp Ala Asp Ser His Phe Gly Met Asp Ser Lys Leu 
225                 230                 235                 240 


Ala Gly Ile Val Ile Pro Asn Asp Gly Leu Cys His Leu Asp Ser Lys 
                245                 250                 255     


Asn Glu Tyr Ser Met Ser Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln 
            260                 265                 270         


Leu Ile Asp Lys Leu Val Gln Asn Asn Val Leu Leu Ile Phe Ala Val 
        275                 280                 285             


Thr Gln Glu Gln Val His Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro 
    290                 295                 300                 


Gly Ala Thr Val Gly Leu Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln 
305                 310                 315                 320 


Leu Ile Ile Ser Ala Tyr Glu Glu Leu Arg Ser Glu Val Glu Leu Glu 
                325                 330                 335     


Val Leu Gly Asp Thr Glu Gly Leu Asn Leu Ser Phe Thr Ala Ile Cys 
            340                 345                 350         


Asn Asn Gly Thr Leu Phe Gln His Gln Lys Lys Cys Ser His Met Lys 
        355                 360                 365             


Val Gly Asp Thr Ala Ser Phe Ser Val Thr Val Asn Ile Pro His Cys 
    370                 375                 380                 


Glu Arg Arg Ser Arg His Ile Ile Ile Lys Pro Val Gly Leu Gly Asp 
385                 390                 395                 400 


Ala Leu Glu Leu Leu Val Ser Pro Glu Cys Asn Cys Asp Cys Gln Lys 
                405                 410                 415     


Glu Val Glu Val Asn Ser Ser Lys Cys His His Gly Asn Gly Ser Phe 
            420                 425                 430         


Gln Cys Gly Val Cys Ala Cys His Pro Gly His Met Gly Pro Arg Cys 
        435                 440                 445             


Glu Cys Gly Glu Asp Met Leu Ser Thr Asp Ser Cys Lys Glu Ala Pro 
    450                 455                 460                 


Asp His Pro Ser Cys Ser Gly Arg Gly Asp Cys Tyr Cys Gly Gln Cys 
465                 470                 475                 480 


Ile Cys His Leu Ser Pro Tyr Gly Asn Ile Tyr Gly Pro Tyr Cys Gln 
                485                 490                 495     


Cys Asp Asn Phe Ser Cys Val Arg His Lys Gly Leu Leu Cys Gly Gly 
            500                 505                 510         


Asn Gly Asp Cys Asp Cys Gly Glu Cys Val Cys Arg Ser Gly Trp Thr 
        515                 520                 525             


Gly Glu Tyr Cys Asn Cys Thr Thr Ser Thr Asp Ser Cys Val Ser Glu 
    530                 535                 540                 


Asp Gly Val Leu Cys Ser Gly Arg Gly Asp Cys Val Cys Gly Lys Cys 
545                 550                 555                 560 


Val Cys Thr Asn Pro Gly Ala Ser Gly Pro Thr Cys Glu Arg Cys Pro 
                565                 570                 575     


Thr Cys Gly Asp Pro Cys Asn Ser Lys Arg Ser Cys Ile Glu Cys His 
            580                 585                 590         


Leu Ser Ala Ala Gly Gln Ala Arg Glu Glu Cys Val Asp Lys Cys Lys 
        595                 600                 605             


Leu Ala Gly Ala Thr Ile Ser Glu Glu Glu Asp Phe Ser Lys Asp Gly 
    610                 615                 620                 


Ser Val Ser Cys Ser Leu Gln Gly Glu Asn Glu Cys Leu Ile Thr Phe 
625                 630                 635                 640 


Leu Ile Thr Thr Asp Asn Glu Gly Lys Thr Ile Ile His Ser Ile Asn 
                645                 650                 655     


Glu Lys Asp Cys Pro Lys Pro Pro Asn Ile Pro Met Ile Met Leu Gly 
            660                 665                 670         


Val Ser Leu Ala Ile Leu Leu Ile Gly Val Val Leu Leu Cys Ile Trp 
        675                 680                 685             


Lys Leu Leu Val Ser Phe His Asp Arg Lys Glu Val Ala Lys Phe Glu 
    690                 695                 700                 


Ala Glu Arg Ser Lys Ala Lys Trp Gln Thr Gly Thr Asn Pro Leu Tyr 
705                 710                 715                 720 


Arg Gly Ser Thr Ser Thr Phe Lys Asn Val Thr Tyr Lys His Arg Glu 
                725                 730                 735     


Lys Gln Lys Val Asp Leu Ser Thr Asp Cys 
            740                 745     


<210>  255
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Cys Gly Ser Ala Leu Ala Phe Phe Thr Ala Ala Phe Val Cys Leu 
1               5                   10                  15      


Gln Asn Asp Arg Arg Gly Pro Ala Ser Phe Leu Trp Ala Ala Trp Val 
            20                  25                  30          


Phe Ser Leu Val Leu Gly Leu Gly Gln Gly Glu Asp Asn Arg Cys Ala 
        35                  40                  45              


Ser Ser Asn Ala Ala Ser Cys Ala Arg Cys Leu Ala Leu Gly Pro Glu 
    50                  55                  60                  


Cys Gly Trp Cys Val Gln Glu Asp Phe Ile Ser Gly Gly Ser Arg Ser 
65                  70                  75                  80  


Glu Arg Cys Asp Ile Val Ser Asn Leu Ile Ser Lys Gly Cys Ser Val 
                85                  90                  95      


Asp Ser Ile Glu Tyr Pro Ser Val His Val Ile Ile Pro Thr Glu Asn 
            100                 105                 110         


Glu Ile Asn Thr Gln Val Thr Pro Gly Glu Val Ser Ile Gln Leu Arg 
        115                 120                 125             


Pro Gly Ala Glu Ala Asn Phe Met Leu Lys Val His Pro Leu Lys Lys 
    130                 135                 140                 


Tyr Pro Val Asp Leu Tyr Tyr Leu Val Asp Val Ser Ala Ser Met His 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Leu Asn Ser Val Gly Asn Asp Leu Ser Arg Lys 
                165                 170                 175     


Met Ala Phe Phe Ser Arg Asp Phe Arg Leu Gly Phe Gly Ser Tyr Val 
            180                 185                 190         


Asp Lys Thr Val Ser Pro Tyr Ile Ser Ile His Pro Glu Arg Ile His 
        195                 200                 205             


Asn Gln Cys Ser Asp Tyr Asn Leu Asp Cys Met Pro Pro His Gly Tyr 
    210                 215                 220                 


Ile His Val Leu Ser Leu Thr Glu Asn Ile Thr Glu Phe Glu Lys Ala 
225                 230                 235                 240 


Val His Arg Gln Lys Ile Ser Gly Asn Ile Asp Thr Pro Glu Gly Gly 
                245                 250                 255     


Phe Asp Ala Met Leu Gln Ala Ala Val Cys Glu Ser His Ile Gly Trp 
            260                 265                 270         


Arg Lys Glu Ala Lys Arg Leu Leu Leu Val Met Thr Asp Gln Thr Ser 
        275                 280                 285             


His Leu Ala Leu Asp Ser Lys Leu Ala Gly Ile Val Val Pro Asn Asp 
    290                 295                 300                 


Gly Asn Cys His Leu Lys Asn Asn Val Tyr Val Lys Ser Thr Thr Met 
305                 310                 315                 320 


Glu His Pro Ser Leu Gly Gln Leu Ser Glu Lys Leu Ile Asp Asn Asn 
                325                 330                 335     


Ile Asn Val Ile Phe Ala Val Gln Gly Lys Gln Phe His Trp Tyr Lys 
            340                 345                 350         


Asp Leu Leu Pro Leu Leu Pro Gly Thr Ile Ala Gly Glu Ile Glu Ser 
        355                 360                 365             


Lys Ala Ala Asn Leu Asn Asn Leu Val Val Glu Ala Tyr Gln Lys Leu 
    370                 375                 380                 


Ile Ser Glu Val Lys Val Gln Val Glu Asn Gln Val Gln Gly Ile Tyr 
385                 390                 395                 400 


Phe Asn Ile Thr Ala Ile Cys Pro Asp Gly Ser Arg Lys Pro Gly Met 
                405                 410                 415     


Glu Gly Cys Arg Asn Val Thr Ser Asn Asp Glu Val Leu Phe Asn Val 
            420                 425                 430         


Thr Val Thr Met Lys Lys Cys Asp Val Thr Gly Gly Lys Asn Tyr Ala 
        435                 440                 445             


Ile Ile Lys Pro Ile Gly Phe Asn Glu Thr Ala Lys Ile His Ile His 
    450                 455                 460                 


Arg Asn Cys Ser Cys Gln Cys Glu Asp Asn Arg Gly Pro Lys Gly Lys 
465                 470                 475                 480 


Cys Val Asp Glu Thr Phe Leu Asp Ser Lys Cys Phe Gln Cys Asp Glu 
                485                 490                 495     


Asn Lys Cys His Phe Asp Glu Asp Gln Phe Ser Ser Glu Ser Cys Lys 
            500                 505                 510         


Ser His Lys Asp Gln Pro Val Cys Ser Gly Arg Gly Val Cys Val Cys 
        515                 520                 525             


Gly Lys Cys Ser Cys His Lys Ile Lys Leu Gly Lys Val Tyr Gly Lys 
    530                 535                 540                 


Tyr Cys Glu Lys Asp Asp Phe Ser Cys Pro Tyr His His Gly Asn Leu 
545                 550                 555                 560 


Cys Ala Gly His Gly Glu Cys Glu Ala Gly Arg Cys Gln Cys Phe Ser 
                565                 570                 575     


Gly Trp Glu Gly Asp Arg Cys Gln Cys Pro Ser Ala Ala Ala Gln His 
            580                 585                 590         


Cys Val Asn Ser Lys Gly Gln Val Cys Ser Gly Arg Gly Thr Cys Val 
        595                 600                 605             


Cys Gly Arg Cys Glu Cys Thr Asp Pro Arg Ser Ile Gly Arg Phe Cys 
    610                 615                 620                 


Glu His Cys Pro Thr Cys Tyr Thr Ala Cys Lys Glu Asn Trp Asn Cys 
625                 630                 635                 640 


Met Gln Cys Leu His Pro His Asn Leu Ser Gln Ala Ile Leu Asp Gln 
                645                 650                 655     


Cys Lys Thr Ser Cys Ala Leu Met Glu Gln Gln His Tyr Val Asp Gln 
            660                 665                 670         


Thr Ser Glu Cys Phe Ser Ser Pro Ser Tyr Leu Arg Ile Phe Phe Ile 
        675                 680                 685             


Ile Phe Ile Val Thr Phe Leu Ile Gly Leu Leu Lys Val Leu Ile Ile 
    690                 695                 700                 


Arg Gln Val Ile Leu Gln Trp Asn Ser Asn Lys Ile Lys Ser Ser Ser 
705                 710                 715                 720 


Asp Tyr Arg Val Ser Ala Ser Lys Lys Asp Lys Leu Ile Leu Gln Ser 
                725                 730                 735     


Val Cys Thr Arg Ala Val Thr Tyr Arg Arg Glu Lys Pro Glu Glu Ile 
            740                 745                 750         


Lys Met Asp Ile Ser Lys Leu Asn Ala His Glu Thr Phe Arg Cys Asn 
        755                 760                 765             


Phe 
    


<210>  256
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Arg Ser Glu Lys Ser Leu Thr Leu Ala Ala Pro Gly Glu Val Arg 
1               5                   10                  15      


Gly Pro Glu Gly Glu Gln Gln Asp Ala Gly Asp Phe Pro Glu Ala Gly 
            20                  25                  30          


Gly Gly Gly Gly Cys Cys Ser Ser Glu Arg Leu Val Ile Asn Ile Ser 
        35                  40                  45              


Gly Leu Arg Phe Glu Thr Gln Leu Arg Thr Leu Ser Leu Phe Pro Asp 
    50                  55                  60                  


Thr Leu Leu Gly Asp Pro Gly Arg Arg Val Arg Phe Phe Asp Pro Leu 
65                  70                  75                  80  


Arg Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile 
                85                  90                  95      


Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val 
            100                 105                 110         


Pro Leu Asp Ile Phe Leu Glu Glu Ile Arg Phe Tyr Gln Leu Gly Asp 
        115                 120                 125             


Glu Ala Leu Ala Ala Phe Arg Glu Asp Glu Gly Cys Leu Pro Glu Gly 
    130                 135                 140                 


Gly Glu Asp Glu Lys Pro Leu Pro Ser Gln Pro Phe Gln Arg Gln Val 
145                 150                 155                 160 


Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile 
                165                 170                 175     


Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys 
            180                 185                 190         


Leu Glu Thr Leu Pro Gln Phe Arg Val Asp Gly Arg Gly Gly Asn Asn 
        195                 200                 205             


Gly Gly Val Ser Arg Val Ser Pro Val Ser Arg Gly Ser Gln Glu Glu 
    210                 215                 220                 


Glu Glu Asp Glu Asp Asp Ser Tyr Thr Phe His His Gly Ile Thr Pro 
225                 230                 235                 240 


Gly Glu Met Gly Thr Gly Gly Ser Ser Ser Leu Ser Thr Leu Gly Gly 
                245                 250                 255     


Ser Phe Phe Thr Asp Pro Phe Phe Leu Val Glu Thr Leu Cys Ile Val 
            260                 265                 270         


Trp Phe Thr Phe Glu Leu Leu Val Arg Phe Ser Ala Cys Pro Ser Lys 
        275                 280                 285             


Pro Ala Phe Phe Arg Asn Ile Met Asn Ile Ile Asp Leu Val Ala Ile 
    290                 295                 300                 


Phe Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Val Gln Gln Gln Glu 
305                 310                 315                 320 


Gln Gln Pro Ala Ser Gly Gly Gly Gly Gln Asn Gly Gln Gln Ala Met 
                325                 330                 335     


Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile 
            340                 345                 350         


Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Lys Thr 
        355                 360                 365             


Leu Gln Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe 
    370                 375                 380                 


Ile Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Asp 
385                 390                 395                 400 


Asp Asp Asp Ser Leu Phe Pro Ser Ile Pro Asp Ala Phe Trp Trp Ala 
                405                 410                 415     


Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Met Thr 
            420                 425                 430         


Val Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu 
        435                 440                 445             


Thr Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe 
    450                 455                 460                 


Tyr His Arg Glu Thr Glu Gln Glu Glu Gln Gly Gln Tyr Thr His Val 
465                 470                 475                 480 


Thr Cys Gly Gln Pro Ala Pro Asp Leu Arg Ala Thr Asp Asn Gly Leu 
                485                 490                 495     


Gly Lys Pro Asp Phe Pro Glu Ala Asn Arg Glu Arg Arg Pro Ser Tyr 
            500                 505                 510         


Leu Pro Thr Pro His Arg Ala Tyr Ala Glu Lys Arg Met Leu Thr Glu 
        515                 520                 525             


Val 
    


<210>  257
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Pro Ala Gly Met Thr Lys His Gly Ser Arg Ser Thr Ser Ser Leu 
1               5                   10                  15      


Pro Pro Glu Pro Met Glu Ile Val Arg Ser Lys Ala Cys Ser Arg Arg 
            20                  25                  30          


Val Arg Leu Asn Val Gly Gly Leu Ala His Glu Val Leu Trp Arg Thr 
        35                  40                  45              


Leu Asp Arg Leu Pro Arg Thr Arg Leu Gly Lys Leu Arg Asp Cys Asn 
    50                  55                  60                  


Thr His Asp Ser Leu Leu Glu Val Cys Asp Asp Tyr Ser Leu Asp Asp 
65                  70                  75                  80  


Asn Glu Tyr Phe Phe Asp Arg His Pro Gly Ala Phe Thr Ser Ile Leu 
                85                  90                  95      


Asn Phe Tyr Arg Thr Gly Arg Leu His Met Met Glu Glu Met Cys Ala 
            100                 105                 110         


Leu Ser Phe Ser Gln Glu Leu Asp Tyr Trp Gly Ile Asp Glu Ile Tyr 
        115                 120                 125             


Leu Glu Ser Cys Cys Gln Ala Arg Tyr His Gln Lys Lys Glu Gln Met 
    130                 135                 140                 


Asn Glu Glu Leu Lys Arg Glu Ala Glu Thr Leu Arg Glu Arg Glu Gly 
145                 150                 155                 160 


Glu Glu Phe Asp Asn Thr Cys Cys Ala Glu Lys Arg Lys Lys Leu Trp 
                165                 170                 175     


Asp Leu Leu Glu Lys Pro Asn Ser Ser Val Ala Ala Lys Ile Leu Ala 
            180                 185                 190         


Ile Ile Ser Ile Met Phe Ile Val Leu Ser Thr Ile Ala Leu Ser Leu 
        195                 200                 205             


Asn Thr Leu Pro Glu Leu Gln Ser Leu Asp Glu Phe Gly Gln Ser Thr 
    210                 215                 220                 


Asp Asn Pro Gln Leu Ala His Val Glu Ala Val Cys Ile Ala Trp Phe 
225                 230                 235                 240 


Thr Met Glu Tyr Leu Leu Arg Phe Leu Ser Ser Pro Lys Lys Trp Lys 
                245                 250                 255     


Phe Phe Lys Gly Pro Leu Asn Ala Ile Asp Leu Leu Ala Ile Leu Pro 
            260                 265                 270         


Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys Ser Val Leu Gln 
        275                 280                 285             


Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg Ile Met Arg Ile 
    290                 295                 300                 


Leu Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Gln Ser Leu 
305                 310                 315                 320 


Gly Phe Thr Leu Arg Arg Ser Tyr Asn Glu Leu Gly Leu Leu Ile Leu 
                325                 330                 335     


Phe Leu Ala Met Gly Ile Met Ile Phe Ser Ser Leu Val Phe Phe Ala 
            340                 345                 350         


Glu Lys Asp Glu Asp Asp Thr Lys Phe Lys Ser Ile Pro Ala Ser Phe 
        355                 360                 365             


Trp Trp Ala Thr Ile Thr Met Thr Thr Val Gly Tyr Gly Asp Ile Tyr 
    370                 375                 380                 


Pro Lys Thr Leu Leu Gly Lys Ile Val Gly Gly Leu Cys Cys Ile Ala 
385                 390                 395                 400 


Gly Val Leu Val Ile Ala Leu Pro Ile Pro Ile Ile Val Asn Asn Phe 
                405                 410                 415     


Ser Glu Phe Tyr Lys Glu Gln Lys Arg Gln Glu Lys Ala Ile Lys Arg 
            420                 425                 430         


Arg Glu Ala Leu Glu Arg Ala Lys Arg Asn Gly Ser Ile Val Ser Met 
        435                 440                 445             


Asn Met Lys Asp Ala Phe Ala Arg Ser Ile Glu Met Met Asp Ile Val 
    450                 455                 460                 


Val Glu Lys Asn Gly Glu Asn Met Gly Lys Lys Asp Lys Val Gln Asp 
465                 470                 475                 480 


Asn His Leu Ser Pro Asn Lys Trp Lys Trp Thr Lys Arg Thr Leu Ser 
                485                 490                 495     


Glu Thr Ser Ser Ser Lys Ser Phe Glu Thr Lys Glu Gln Gly Ser Pro 
            500                 505                 510         


Glu Lys Ala Arg Ser Ser Ser Ser Pro Gln His Leu Asn Val Gln Gln 
        515                 520                 525             


Leu Glu Asp Met Tyr Asn Lys Met Ala Lys Thr Gln Ser Gln Pro Ile 
    530                 535                 540                 


Leu Asn Thr Lys Glu Ser Ala Ala Gln Ser Lys Pro Lys Glu Glu Leu 
545                 550                 555                 560 


Glu Met Glu Ser Ile Pro Ser Pro Val Ala Pro Leu Pro Thr Arg Thr 
                565                 570                 575     


Glu Gly Val Ile Asp Met Arg Ser Met Ser Ser Ile Asp Ser Phe Ile 
            580                 585                 590         


Ser Cys Ala Thr Asp Phe Pro Glu Ala Thr Arg Phe Ser His Ser Pro 
        595                 600                 605             


Leu Thr Ser Leu Pro Ser Lys Thr Gly Gly Ser Thr Ala Pro Glu Val 
    610                 615                 620                 


Gly Trp Arg Gly Ala Leu Gly Ala Ser Gly Gly Arg Phe Val Glu Ala 
625                 630                 635                 640 


Asn Pro Ser Pro Asp Ala Ser Gln His Ser Ser Phe Phe Ile Glu Ser 
                645                 650                 655     


Pro Lys Ser Ser Met Lys Thr Asn Asn Pro Leu Lys Leu Arg Ala Leu 
            660                 665                 670         


Lys Val Asn Phe Met Glu Gly Asp Pro Ser Pro Leu Leu Pro Val Leu 
        675                 680                 685             


Gly Met Tyr His Asp Pro Leu Arg Asn Arg Gly Ser Ala Ala Ala Ala 
    690                 695                 700                 


Val Ala Gly Leu Glu Cys Ala Thr Leu Leu Asp Lys Ala Val Leu Ser 
705                 710                 715                 720 


Pro Glu Ser Ser Ile Tyr Thr Thr Ala Ser Ala Lys Thr Pro Pro Arg 
                725                 730                 735     


Ser Pro Glu Lys His Thr Ala Ile Ala Phe Asn Phe Glu Ala Gly Val 
            740                 745                 750         


His Gln Tyr Ile Asp Ala Asp Thr Asp Asp Glu Gly Gln Leu Leu Tyr 
        755                 760                 765             


Ser Val Asp Ser Ser Pro Pro Lys Ser Leu Pro Gly Ser Thr Ser Pro 
    770                 775                 780                 


Lys Phe Ser Thr Gly Thr Arg Ser Glu Lys Asn His Phe Glu Ser Ser 
785                 790                 795                 800 


Pro Leu Pro Thr Ser Pro Lys Phe Leu Arg Gln Asn Cys Ile Tyr Ser 
                805                 810                 815     


Thr Glu Ala Leu Thr Gly Lys Gly Pro Ser Gly Gln Glu Lys Cys Lys 
            820                 825                 830         


Leu Glu Asn His Ile Ser Pro Asp Val Arg Val Leu Pro Gly Gly Gly 
        835                 840                 845             


Ala His Gly Ser Thr Arg Asp Gln Ser Ile 
    850                 855             


<210>  258
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  258

Met His Phe Leu Thr Ile Tyr Pro Asn Cys Ser Ser Gly Val Val Arg 
1               5                   10                  15      


Ala Gln Ser Arg Thr Glu Gln Lys Asn Pro Leu Gly Leu Asp Asp Leu 
            20                  25                  30          


Gly Ile Gln Asn Leu Gly Gln Thr Val Ser Leu Ala Pro Ala Val Glu 
        35                  40                  45              


Ala Ala Ser Met Leu Lys Met Glu Pro Leu Asn Ser Thr His Pro Gly 
    50                  55                  60                  


Thr Ala Ala Ser Ser Ser Pro Leu Glu Ser Arg Ala Ala Gly Gly Gly 
65                  70                  75                  80  


Ser Gly Asn Gly Asn Glu Tyr Phe Tyr Ile Leu Val Val Met Ser Phe 
                85                  90                  95      


Tyr Gly Ile Phe Leu Ile Gly Ile Met Leu Gly Tyr Met Lys Ser Lys 
            100                 105                 110         


Arg Arg Glu Lys Lys Ser Ser Leu Leu Leu Leu Tyr Lys Asp Glu Glu 
        115                 120                 125             


Arg Leu Trp Gly Glu Ala Met Lys Pro Leu Pro Val Val Ser Gly Leu 
    130                 135                 140                 


Arg Ser Val Gln Val Pro Leu Met Leu Asn Met Leu Gln Glu Ser Val 
145                 150                 155                 160 


Ala Pro Ala Leu Ser Cys Thr Leu Cys Ser Met Glu Gly Asp Ser Val 
                165                 170                 175     


Ser Ser Glu Ser Ser Ser Pro Asp Val His Leu Thr Ile Gln Glu Glu 
            180                 185                 190         


Gly Ala Asp Asp Glu Leu Glu Glu Thr Ser Glu Thr Pro Leu Asn Glu 
        195                 200                 205             


Ser Ser Glu Gly Ser Ser Glu Asn Ile His Gln Asn Ser 
    210                 215                 220     


<210>  259
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Asn Ala Ser Ser Arg Asn Val Phe Asp Thr Leu Ile Arg Val Leu 
1               5                   10                  15      


Thr Glu Ser Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe 
            20                  25                  30          


Phe Gly His Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg 
        35                  40                  45              


Cys Asn Ile Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe 
    50                  55                  60                  


Phe Val Asp Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys 
65                  70                  75                  80  


Met Thr Ile Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly 
                85                  90                  95      


Leu Leu Trp Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe 
            100                 105                 110         


His Pro Ser Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu 
        115                 120                 125             


Thr Ser Ala Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr 
    130                 135                 140                 


Gly Phe Arg Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu 
145                 150                 155                 160 


Ile Phe Gln Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly 
                165                 170                 175     


Ala Ile Leu Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile 
            180                 185                 190         


Thr Phe Ser Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys 
        195                 200                 205             


Leu Leu Ile Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser 
    210                 215                 220                 


His Ile Tyr Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu 
225                 230                 235                 240 


Thr Ile Ile Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly 
                245                 250                 255     


Asn Glu Asn Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile 
            260                 265                 270         


Asp His Asn Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln 
        275                 280                 285             


Gln Asp Phe Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr 
    290                 295                 300                 


Ser Ala Thr Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu 
305                 310                 315                 320 


Trp Gly Tyr Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys 
                325                 330                 335     


Tyr Arg Val Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr 
            340                 345                 350         


Pro His Cys Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg 
        355                 360                 365             


Met Lys Arg Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn 
    370                 375                 380                 


Glu Thr Asp Asp Thr Lys Met 
385                 390     


<210>  260
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe Phe Gly His 
1               5                   10                  15      


Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg Cys Asn Ile 
            20                  25                  30          


Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe Phe Val Asp 
        35                  40                  45              


Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys Met Thr Ile 
    50                  55                  60                  


Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly Leu Leu Trp 
65                  70                  75                  80  


Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe His Pro Ser 
                85                  90                  95      


Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu Thr Ser Ala 
            100                 105                 110         


Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr Gly Phe Arg 
        115                 120                 125             


Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu Ile Phe Gln 
    130                 135                 140                 


Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly Ala Ile Leu 
145                 150                 155                 160 


Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile Thr Phe Ser 
                165                 170                 175     


Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys Leu Leu Ile 
            180                 185                 190         


Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser His Ile Tyr 
        195                 200                 205             


Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu Thr Ile Ile 
    210                 215                 220                 


Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly Asn Glu Asn 
225                 230                 235                 240 


Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile Asp His Asn 
                245                 250                 255     


Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln Gln Asp Phe 
            260                 265                 270         


Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr Ser Ala Thr 
        275                 280                 285             


Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu Trp Gly Tyr 
    290                 295                 300                 


Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys Tyr Arg Val 
305                 310                 315                 320 


Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr Pro His Cys 
                325                 330                 335     


Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg Met Lys Arg 
            340                 345                 350         


Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn Glu Thr Asp 
        355                 360                 365             


Asp Thr Lys Met 
    370         


<210>  261
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Pro Thr Val Tyr Leu Cys Ser Glu Gln Ile Arg Val Leu Thr Glu 
1               5                   10                  15      


Ser Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe Phe Gly 
            20                  25                  30          


His Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg Cys Asn 
        35                  40                  45              


Ile Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe Phe Val 
    50                  55                  60                  


Asp Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys Met Thr 
65                  70                  75                  80  


Ile Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly Leu Leu 
                85                  90                  95      


Trp Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe His Pro 
            100                 105                 110         


Ser Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu Thr Ser 
        115                 120                 125             


Ala Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr Gly Phe 
    130                 135                 140                 


Arg Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu Ile Phe 
145                 150                 155                 160 


Gln Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly Ala Ile 
                165                 170                 175     


Leu Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile Thr Phe 
            180                 185                 190         


Ser Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys Leu Leu 
        195                 200                 205             


Ile Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser His Ile 
    210                 215                 220                 


Tyr Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu Thr Ile 
225                 230                 235                 240 


Ile Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly Asn Glu 
                245                 250                 255     


Asn Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile Asp His 
            260                 265                 270         


Asn Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln Gln Asp 
        275                 280                 285             


Phe Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr Ser Ala 
    290                 295                 300                 


Thr Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu Trp Gly 
305                 310                 315                 320 


Tyr Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys Tyr Arg 
                325                 330                 335     


Val Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr Pro His 
            340                 345                 350         


Cys Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg Met Lys 
        355                 360                 365             


Arg Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn Glu Thr 
    370                 375                 380                 


Asp Asp Thr Lys Met 
385                 


<210>  262
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe Phe Gly His 
1               5                   10                  15      


Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg Cys Asn Ile 
            20                  25                  30          


Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe Phe Val Asp 
        35                  40                  45              


Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys Met Thr Ile 
    50                  55                  60                  


Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly Leu Leu Trp 
65                  70                  75                  80  


Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe His Pro Ser 
                85                  90                  95      


Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu Thr Ser Ala 
            100                 105                 110         


Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr Gly Phe Arg 
        115                 120                 125             


Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu Ile Phe Gln 
    130                 135                 140                 


Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly Ala Ile Leu 
145                 150                 155                 160 


Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile Thr Phe Ser 
                165                 170                 175     


Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys Leu Leu Ile 
            180                 185                 190         


Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser His Ile Tyr 
        195                 200                 205             


Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu Thr Ile Ile 
    210                 215                 220                 


Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly Asn Glu Asn 
225                 230                 235                 240 


Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile Asp His Asn 
                245                 250                 255     


Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln Gln Asp Phe 
            260                 265                 270         


Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr Ser Ala Thr 
        275                 280                 285             


Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu Trp Gly Tyr 
    290                 295                 300                 


Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys Tyr Arg Val 
305                 310                 315                 320 


Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr Pro His Cys 
                325                 330                 335     


Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg Met Lys Arg 
            340                 345                 350         


Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn Glu Thr Asp 
        355                 360                 365             


Asp Thr Lys Met 
    370         


<210>  263
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe Phe Gly His 
1               5                   10                  15      


Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg Cys Asn Ile 
            20                  25                  30          


Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe Phe Val Asp 
        35                  40                  45              


Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys Met Thr Ile 
    50                  55                  60                  


Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly Leu Leu Trp 
65                  70                  75                  80  


Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe His Pro Ser 
                85                  90                  95      


Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu Thr Ser Ala 
            100                 105                 110         


Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr Gly Phe Arg 
        115                 120                 125             


Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu Ile Phe Gln 
    130                 135                 140                 


Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly Ala Ile Leu 
145                 150                 155                 160 


Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile Thr Phe Ser 
                165                 170                 175     


Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys Leu Leu Ile 
            180                 185                 190         


Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser His Ile Tyr 
        195                 200                 205             


Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu Thr Ile Ile 
    210                 215                 220                 


Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly Asn Glu Asn 
225                 230                 235                 240 


Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile Asp His Asn 
                245                 250                 255     


Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln Gln Asp Phe 
            260                 265                 270         


Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr Ser Ala Thr 
        275                 280                 285             


Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu Trp Gly Tyr 
    290                 295                 300                 


Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys Tyr Arg Val 
305                 310                 315                 320 


Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr Pro His Cys 
                325                 330                 335     


Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg Met Lys Arg 
            340                 345                 350         


Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn Glu Thr Asp 
        355                 360                 365             


Asp Thr Lys Met 
    370         


<210>  264
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala Asp Ala Lys 
1               5                   10                  15      


Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys Arg Arg Ala 
            20                  25                  30          


Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val Tyr Phe Lys 
        35                  40                  45              


His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile Phe Thr Thr 
    50                  55                  60                  


Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe Ser Leu Ser 
65                  70                  75                  80  


Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp Leu Ile Ala 
                85                  90                  95      


Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr Pro Cys Val 
            100                 105                 110         


Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser Leu Glu Thr 
        115                 120                 125             


Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu Glu Cys Ser 
    130                 135                 140                 


Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser Cys Ile Ile 
145                 150                 155                 160 


Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala Thr Ala Arg 
                165                 170                 175     


Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu Ile Gly Met 
            180                 185                 190         


Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp Phe Arg Pro 
        195                 200                 205             


Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu Arg Tyr Thr 
    210                 215                 220                 


Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp Leu Lys Leu 
225                 230                 235                 240 


Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile Val His Glu 
                245                 250                 255     


Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys Ala Val Ala 
            260                 265                 270         


Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr Gly Asp Ser 
        275                 280                 285             


Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro Arg Glu Ile 
    290                 295                 300                 


Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys Arg Lys Tyr 
305                 310                 315                 320 


Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu Val Tyr Ala 
                325                 330                 335     


Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln Gln Leu His 
            340                 345                 350         


Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser Asp Thr Lys 
        355                 360                 365             


Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser Ser Cys Glu 
    370                 375                 380                 


Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr Arg Glu Thr 
385                 390                 395                 400 


Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser Val Glu Ser 
                405                 410                 415     


Gln Met 
        


<210>  265
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Leu Lys Met Val Leu Thr Glu Asn Pro Asn Gln Glu Ile Ala Thr 
1               5                   10                  15      


Ser Leu Glu Phe Leu Leu Leu Gln Asn Ser Pro Gly Ser Leu Arg Ala 
            20                  25                  30          


Gln Gln Arg Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala 
        35                  40                  45              


Asp Ala Lys Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys 
    50                  55                  60                  


Arg Arg Ala Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val 
65                  70                  75                  80  


Tyr Phe Lys His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile 
                85                  90                  95      


Phe Thr Thr Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe 
            100                 105                 110         


Ser Leu Ser Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp 
        115                 120                 125             


Leu Ile Ala Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr 
    130                 135                 140                 


Pro Cys Val Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser 
145                 150                 155                 160 


Leu Glu Thr Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu 
                165                 170                 175     


Glu Cys Ser Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser 
            180                 185                 190         


Cys Ile Ile Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala 
        195                 200                 205             


Thr Ala Arg Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu 
    210                 215                 220                 


Ile Gly Met Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp 
225                 230                 235                 240 


Phe Arg Pro Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu 
                245                 250                 255     


Arg Tyr Thr Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp 
            260                 265                 270         


Leu Lys Leu Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile 
        275                 280                 285             


Val His Glu Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys 
    290                 295                 300                 


Ala Val Ala Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr 
305                 310                 315                 320 


Gly Asp Ser Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro 
                325                 330                 335     


Arg Glu Ile Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys 
            340                 345                 350         


Arg Lys Tyr Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu 
        355                 360                 365             


Val Tyr Ala Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln 
    370                 375                 380                 


Gln Leu His Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser 
385                 390                 395                 400 


Asp Thr Lys Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser 
                405                 410                 415     


Ser Cys Glu Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr 
            420                 425                 430         


Arg Glu Thr Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser 
        435                 440                 445             


Val Glu Ser Gln Met 
    450             


<210>  266
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Leu Lys Met Val Leu Thr Glu Asn Pro Asn Gln Glu Ile Ala Thr 
1               5                   10                  15      


Ser Leu Glu Phe Leu Leu Leu Gln Asn Ser Pro Gly Ser Leu Arg Ala 
            20                  25                  30          


Gln Gln Arg Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala 
        35                  40                  45              


Asp Ala Lys Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys 
    50                  55                  60                  


Arg Arg Ala Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val 
65                  70                  75                  80  


Tyr Phe Lys His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile 
                85                  90                  95      


Phe Thr Thr Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe 
            100                 105                 110         


Ser Leu Ser Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp 
        115                 120                 125             


Leu Ile Ala Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr 
    130                 135                 140                 


Pro Cys Val Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser 
145                 150                 155                 160 


Leu Glu Thr Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu 
                165                 170                 175     


Glu Cys Ser Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser 
            180                 185                 190         


Cys Ile Ile Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala 
        195                 200                 205             


Thr Ala Arg Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu 
    210                 215                 220                 


Ile Gly Met Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp 
225                 230                 235                 240 


Phe Arg Pro Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu 
                245                 250                 255     


Arg Tyr Thr Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp 
            260                 265                 270         


Leu Lys Leu Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile 
        275                 280                 285             


Val His Glu Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys 
    290                 295                 300                 


Ala Val Ala Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr 
305                 310                 315                 320 


Gly Asp Ser Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro 
                325                 330                 335     


Arg Glu Ile Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys 
            340                 345                 350         


Arg Lys Tyr Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu 
        355                 360                 365             


Val Tyr Ala Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln 
    370                 375                 380                 


Gln Leu His Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser 
385                 390                 395                 400 


Asp Thr Lys Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser 
                405                 410                 415     


Ser Cys Glu Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr 
            420                 425                 430         


Arg Glu Thr Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser 
        435                 440                 445             


Val Glu Ser Gln Met 
    450             


<210>  267
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala Asp Ala Lys 
1               5                   10                  15      


Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys Arg Arg Ala 
            20                  25                  30          


Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val Tyr Phe Lys 
        35                  40                  45              


His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile Phe Thr Thr 
    50                  55                  60                  


Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe Ser Leu Ser 
65                  70                  75                  80  


Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp Leu Ile Ala 
                85                  90                  95      


Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr Pro Cys Val 
            100                 105                 110         


Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser Leu Glu Thr 
        115                 120                 125             


Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu Glu Cys Ser 
    130                 135                 140                 


Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser Cys Ile Ile 
145                 150                 155                 160 


Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala Thr Ala Arg 
                165                 170                 175     


Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu Ile Gly Met 
            180                 185                 190         


Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp Phe Arg Pro 
        195                 200                 205             


Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu Arg Tyr Thr 
    210                 215                 220                 


Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp Leu Lys Leu 
225                 230                 235                 240 


Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile Val His Glu 
                245                 250                 255     


Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys Ala Val Ala 
            260                 265                 270         


Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr Gly Asp Ser 
        275                 280                 285             


Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro Arg Glu Ile 
    290                 295                 300                 


Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys Arg Lys Tyr 
305                 310                 315                 320 


Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu Val Tyr Ala 
                325                 330                 335     


Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln Gln Leu His 
            340                 345                 350         


Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser Asp Thr Lys 
        355                 360                 365             


Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser Ser Cys Glu 
    370                 375                 380                 


Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr Arg Glu Thr 
385                 390                 395                 400 


Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser Val Glu Ser 
                405                 410                 415     


Gln Met 
        


<210>  268
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala Asp Ala Lys 
1               5                   10                  15      


Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys Arg Arg Ala 
            20                  25                  30          


Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val Tyr Phe Lys 
        35                  40                  45              


His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile Phe Thr Thr 
    50                  55                  60                  


Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe Ser Leu Ser 
65                  70                  75                  80  


Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp Leu Ile Ala 
                85                  90                  95      


Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr Pro Cys Val 
            100                 105                 110         


Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser Leu Glu Thr 
        115                 120                 125             


Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu Glu Cys Ser 
    130                 135                 140                 


Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser Cys Ile Ile 
145                 150                 155                 160 


Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala Thr Ala Arg 
                165                 170                 175     


Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu Ile Gly Met 
            180                 185                 190         


Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp Phe Arg Pro 
        195                 200                 205             


Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu Arg Tyr Thr 
    210                 215                 220                 


Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp Leu Lys Leu 
225                 230                 235                 240 


Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile Val His Glu 
                245                 250                 255     


Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys Ala Val Ala 
            260                 265                 270         


Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr Gly Asp Ser 
        275                 280                 285             


Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro Arg Glu Ile 
    290                 295                 300                 


Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys Arg Lys Tyr 
305                 310                 315                 320 


Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu Val Tyr Ala 
                325                 330                 335     


Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln Gln Leu His 
            340                 345                 350         


Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser Asp Thr Lys 
        355                 360                 365             


Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser Ser Cys Glu 
    370                 375                 380                 


Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr Arg Glu Thr 
385                 390                 395                 400 


Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser Val Glu Ser 
                405                 410                 415     


Gln Met 
        


<210>  269
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Leu Lys Met Val Leu Thr Glu Asn Pro Asn Gln Glu Ile Ala Thr 
1               5                   10                  15      


Ser Leu Glu Phe Leu Leu Leu Gln Asn Ser Pro Gly Ser Leu Arg Ala 
            20                  25                  30          


Gln Gln Arg Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala 
        35                  40                  45              


Asp Ala Lys Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys 
    50                  55                  60                  


Arg Arg Ala Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val 
65                  70                  75                  80  


Tyr Phe Lys His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile 
                85                  90                  95      


Phe Thr Thr Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe 
            100                 105                 110         


Ser Leu Ser Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp 
        115                 120                 125             


Leu Ile Ala Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr 
    130                 135                 140                 


Pro Cys Val Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser 
145                 150                 155                 160 


Leu Glu Thr Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu 
                165                 170                 175     


Glu Cys Ser Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser 
            180                 185                 190         


Cys Ile Ile Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala 
        195                 200                 205             


Thr Ala Arg Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu 
    210                 215                 220                 


Ile Gly Met Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp 
225                 230                 235                 240 


Phe Arg Pro Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu 
                245                 250                 255     


Arg Tyr Thr Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp 
            260                 265                 270         


Leu Lys Leu Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile 
        275                 280                 285             


Val His Glu Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys 
    290                 295                 300                 


Ala Val Ala Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr 
305                 310                 315                 320 


Gly Asp Ser Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro 
                325                 330                 335     


Arg Glu Ile Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys 
            340                 345                 350         


Arg Lys Tyr Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu 
        355                 360                 365             


Val Tyr Ala Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln 
    370                 375                 380                 


Gln Leu His Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser 
385                 390                 395                 400 


Asp Thr Lys Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser 
                405                 410                 415     


Ser Cys Glu Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr 
            420                 425                 430         


Arg Glu Thr Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser 
        435                 440                 445             


Val Glu Ser Gln Met 
    450             


<210>  270
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Leu Lys Met Val Leu Thr Glu Asn Pro Asn Gln Glu Ile Ala Thr 
1               5                   10                  15      


Ser Leu Glu Phe Leu Leu Leu Gln Asn Ser Pro Gly Ser Leu Arg Ala 
            20                  25                  30          


Gln Gln Arg Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala 
        35                  40                  45              


Asp Ala Lys Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys 
    50                  55                  60                  


Arg Arg Ala Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val 
65                  70                  75                  80  


Tyr Phe Lys His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile 
                85                  90                  95      


Phe Thr Thr Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe 
            100                 105                 110         


Ser Leu Ser Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp 
        115                 120                 125             


Leu Ile Ala Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr 
    130                 135                 140                 


Pro Cys Val Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser 
145                 150                 155                 160 


Leu Glu Thr Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu 
                165                 170                 175     


Glu Cys Ser Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser 
            180                 185                 190         


Cys Ile Ile Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala 
        195                 200                 205             


Thr Ala Arg Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu 
    210                 215                 220                 


Ile Gly Met Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp 
225                 230                 235                 240 


Phe Arg Pro Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu 
                245                 250                 255     


Arg Tyr Thr Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp 
            260                 265                 270         


Leu Lys Leu Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile 
        275                 280                 285             


Val His Glu Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys 
    290                 295                 300                 


Ala Val Ala Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr 
305                 310                 315                 320 


Gly Asp Ser Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro 
                325                 330                 335     


Arg Glu Ile Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys 
            340                 345                 350         


Arg Lys Tyr Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu 
        355                 360                 365             


Val Tyr Ala Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln 
    370                 375                 380                 


Gln Leu His Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser 
385                 390                 395                 400 


Asp Thr Lys Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser 
                405                 410                 415     


Ser Cys Glu Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr 
            420                 425                 430         


Arg Glu Thr Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser 
        435                 440                 445             


Val Glu Ser Gln Met 
    450             


<210>  271
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  271

Met Leu Lys Met Val Leu Thr Glu Asn Pro Asn Gln Glu Ile Ala Thr 
1               5                   10                  15      


Ser Leu Glu Phe Leu Leu Leu Gln Asn Ser Pro Gly Ser Leu Arg Ala 
            20                  25                  30          


Gln Gln Arg Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala 
        35                  40                  45              


Asp Ala Lys Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys 
    50                  55                  60                  


Arg Arg Ala Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val 
65                  70                  75                  80  


Tyr Phe Lys His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile 
                85                  90                  95      


Phe Thr Thr Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe 
            100                 105                 110         


Ser Leu Ser Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp 
        115                 120                 125             


Leu Ile Ala Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr 
    130                 135                 140                 


Pro Cys Val Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser 
145                 150                 155                 160 


Leu Glu Thr Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu 
                165                 170                 175     


Glu Cys Ser Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser 
            180                 185                 190         


Cys Ile Ile Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala 
        195                 200                 205             


Thr Ala Arg Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu 
    210                 215                 220                 


Ile Gly Met Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp 
225                 230                 235                 240 


Phe Arg Pro Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu 
                245                 250                 255     


Arg Tyr Thr Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp 
            260                 265                 270         


Leu Lys Leu Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile 
        275                 280                 285             


Val His Glu Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys 
    290                 295                 300                 


Ala Val Ala Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr 
305                 310                 315                 320 


Gly Asp Ser Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro 
                325                 330                 335     


Arg Glu Ile Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys 
            340                 345                 350         


Arg Lys Tyr Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu 
        355                 360                 365             


Val Tyr Ala Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln 
    370                 375                 380                 


Gln Leu His Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser 
385                 390                 395                 400 


Asp Thr Lys Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser 
                405                 410                 415     


Ser Cys Glu Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr 
            420                 425                 430         


Arg Glu Thr Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser 
        435                 440                 445             


Val Glu Ser Gln Met 
    450             


<210>  272
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Ala Gly Asp Ser Arg Asn Ala Met Asn Gln Asp Met Glu Ile Gly 
1               5                   10                  15      


Val Thr Pro Trp Asp Pro Lys Lys Ile Pro Lys Gln Ala Arg Asp Tyr 
            20                  25                  30          


Val Pro Ile Ala Thr Asp Arg Thr Arg Leu Leu Ala Glu Gly Lys Lys 
        35                  40                  45              


Pro Arg Gln Arg Tyr Met Glu Lys Ser Gly Lys Cys Asn Val His His 
    50                  55                  60                  


Gly Asn Val Gln Glu Thr Tyr Arg Tyr Leu Ser Asp Leu Phe Thr Thr 
65                  70                  75                  80  


Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu Val Phe Thr Met Val 
                85                  90                  95      


Tyr Thr Val Thr Trp Leu Phe Phe Gly Phe Ile Trp Trp Leu Ile Ala 
            100                 105                 110         


Tyr Ile Arg Gly Asp Leu Asp His Val Gly Asp Gln Glu Trp Ile Pro 
        115                 120                 125             


Cys Val Glu Asn Leu Ser Gly Phe Val Ser Ala Phe Leu Phe Ser Ile 
    130                 135                 140                 


Glu Thr Glu Thr Thr Ile Gly Tyr Gly Phe Arg Val Ile Thr Glu Lys 
145                 150                 155                 160 


Cys Pro Glu Gly Ile Ile Leu Leu Leu Val Gln Ala Ile Leu Gly Ser 
                165                 170                 175     


Ile Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys Ile Ser Gln 
            180                 185                 190         


Pro Lys Lys Arg Ala Glu Thr Leu Met Phe Ser Asn Asn Ala Val Ile 
        195                 200                 205             


Ser Met Arg Asp Glu Lys Leu Cys Leu Met Phe Arg Val Gly Asp Leu 
    210                 215                 220                 


Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys Leu Ile Lys 
225                 230                 235                 240 


Ser Arg Gln Thr Lys Glu Gly Glu Phe Ile Pro Leu Asn Gln Thr Asp 
                245                 250                 255     


Ile Asn Val Gly Phe Asp Thr Gly Asp Asp Arg Leu Phe Leu Val Ser 
            260                 265                 270         


Pro Leu Ile Ile Ser His Glu Ile Asn Gln Lys Ser Pro Phe Trp Glu 
        275                 280                 285             


Met Ser Gln Ala Gln Leu His Gln Glu Glu Phe Glu Val Val Val Ile 
    290                 295                 300                 


Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln Ala Arg Ser 
305                 310                 315                 320 


Ser Tyr Met Asp Thr Glu Val Leu Trp Gly His Arg Phe Thr Pro Val 
                325                 330                 335     


Leu Thr Leu Glu Lys Gly Phe Tyr Glu Val Asp Tyr Asn Thr Phe His 
            340                 345                 350         


Asp Thr Tyr Glu Thr Asn Thr Pro Ser Cys Cys Ala Lys Glu Leu Ala 
        355                 360                 365             


Glu Met Lys Arg Glu Gly Arg Leu Leu Gln Tyr Leu Pro Ser Pro Pro 
    370                 375                 380                 


Leu Leu Gly Gly Cys Ala Glu Ala Gly Leu Asp Ala Glu Ala Glu Gln 
385                 390                 395                 400 


Asn Glu Glu Asp Glu Pro Lys Gly Leu Gly Gly Ser Arg Glu Ala Arg 
                405                 410                 415     


Gly Ser Val 
            


<210>  273
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Arg Arg Pro Ser Val Arg Ala Ala Gly Leu Val Leu Cys Thr Leu 
1               5                   10                  15      


Cys Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Glu 
            20                  25                  30          


Ala Glu Ser Gly Arg Gln Arg Leu Leu Val Gln Lys Arg Gly Ala Leu 
        35                  40                  45              


Arg Arg Lys Phe Gly Phe Ser Ala Glu Asp Tyr Arg Glu Leu Glu Arg 
    50                  55                  60                  


Leu Ala Leu Gln Ala Glu Pro His Arg Ala Gly Arg Gln Trp Lys Phe 
65                  70                  75                  80  


Pro Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Glu Tyr 
                85                  90                  95      


Gly His Ala Ala Pro Gly Thr Asp Ser Gly Lys Val Phe Cys Met Phe 
            100                 105                 110         


Tyr Ala Leu Leu Gly Ile Pro Leu Thr Leu Val Thr Phe Gln Ser Leu 
        115                 120                 125             


Gly Glu Arg Leu Asn Ala Val Val Arg Arg Leu Leu Leu Ala Ala Lys 
    130                 135                 140                 


Cys Cys Leu Gly Leu Arg Trp Thr Cys Val Ser Thr Glu Asn Leu Val 
145                 150                 155                 160 


Val Ala Gly Leu Leu Ala Cys Ala Ala Thr Leu Ala Leu Gly Ala Val 
                165                 170                 175     


Ala Phe Ser His Phe Glu Gly Trp Thr Phe Phe His Ala Tyr Tyr Tyr 
            180                 185                 190         


Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Phe Val Ala Leu 
        195                 200                 205             


Gln Ser Gly Glu Ala Leu Gln Arg Lys Leu Pro Tyr Val Ala Phe Ser 
    210                 215                 220                 


Phe Leu Tyr Ile Leu Leu Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 
225                 230                 235                 240 


Leu Val Val Leu Arg Phe Leu Val Ala Ser Ala Asp Trp Pro Glu Arg 
                245                 250                 255     


Ala Ala Arg Thr Pro Ser Pro Arg Pro Pro Gly Ala Pro Glu Ser Arg 
            260                 265                 270         


Gly Leu Trp Leu Pro Arg Arg Pro Ala Arg Ser Val Gly Ser Ala Ser 
        275                 280                 285             


Val Phe Cys His Val His Lys Leu Glu Arg Cys Ala Arg Asp Asn Leu 
    290                 295                 300                 


Gly Phe Ser Pro Pro Ser Ser Pro Gly Val Val Arg Gly Gly Gln Ala 
305                 310                 315                 320 


Pro Arg Leu Gly Ala Arg Trp Lys Ser Ile 
                325                 330 


<210>  274
<211>  1356
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  275
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  275

Met His Thr Val Ala Thr Ser Gly Pro Asn Ala Ser Trp Gly Ala Pro 
1               5                   10                  15      


Ala Asn Ala Ser Gly Cys Pro Gly Cys Gly Ala Asn Ala Ser Asp Gly 
            20                  25                  30          


Pro Val Pro Ser Pro Arg Ala Val Asp Ala Trp Leu Val Pro Leu Phe 
        35                  40                  45              


Phe Ala Ala Leu Met Leu Leu Gly Leu Val Gly Asn Ser Leu Val Ile 
    50                  55                  60                  


Tyr Val Ile Cys Arg His Lys Pro Met Arg Thr Val Thr Asn Phe Tyr 
65                  70                  75                  80  


Ile Ala Asn Leu Ala Ala Thr Asp Val Thr Phe Leu Leu Cys Cys Val 
                85                  90                  95      


Pro Phe Thr Ala Leu Leu Tyr Pro Leu Pro Gly Trp Val Leu Gly Asp 
            100                 105                 110         


Phe Met Cys Lys Phe Val Asn Tyr Ile Gln Gln Val Ser Val Gln Ala 
        115                 120                 125             


Thr Cys Ala Thr Leu Thr Ala Met Ser Val Asp Arg Trp Tyr Val Thr 
    130                 135                 140                 


Val Phe Pro Leu Arg Ala Leu His Arg Arg Thr Pro Arg Leu Ala Leu 
145                 150                 155                 160 


Ala Val Ser Leu Ser Ile Trp Val Gly Ser Ala Ala Val Ser Ala Pro 
                165                 170                 175     


Val Leu Ala Leu His Arg Leu Ser Pro Gly Pro Arg Ala Tyr Cys Ser 
            180                 185                 190         


Glu Ala Phe Pro Ser Arg Ala Leu Glu Arg Ala Phe Ala Leu Tyr Asn 
        195                 200                 205             


Leu Leu Ala Leu Tyr Leu Leu Pro Leu Leu Ala Thr Cys Ala Cys Tyr 
    210                 215                 220                 


Ala Ala Met Leu Arg His Leu Gly Arg Val Ala Val Arg Pro Ala Pro 
225                 230                 235                 240 


Ala Asp Ser Ala Leu Gln Gly Gln Val Leu Ala Glu Arg Ala Gly Ala 
                245                 250                 255     


Val Arg Ala Lys Val Ser Arg Leu Val Ala Ala Val Val Leu Leu Phe 
            260                 265                 270         


Ala Ala Cys Trp Gly Pro Ile Gln Leu Phe Leu Val Leu Gln Ala Leu 
        275                 280                 285             


Gly Pro Ala Gly Ser Trp His Pro Arg Ser Tyr Ala Ala Tyr Ala Leu 
    290                 295                 300                 


Lys Thr Trp Ala His Cys Met Ser Tyr Ser Asn Ser Ala Leu Asn Pro 
305                 310                 315                 320 


Leu Leu Tyr Ala Phe Leu Gly Ser His Phe Arg Gln Ala Phe Arg Arg 
                325                 330                 335     


Val Cys Pro Cys Ala Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro Gly 
            340                 345                 350         


Pro Ser Asp Pro Ala Ala Pro His Ala Glu Leu Leu Arg Leu Gly Ser 
        355                 360                 365             


His Pro Ala Pro Ala Arg Ala Gln Lys Pro Gly Ser Ser Gly Leu Ala 
    370                 375                 380                 


Ala Arg Gly Leu Cys Val Leu Gly Glu Asp Asn Ala Pro Leu 
385                 390                 395             


<210>  276
<211>  1257
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 
                85                  90                  95      


Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 
            100                 105                 110         


Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 
        115                 120                 125             


Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 
    130                 135                 140                 


Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 
145                 150                 155                 160 


Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 
                165                 170                 175     


Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 
            180                 185                 190         


Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 
        195                 200                 205             


Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 
    210                 215                 220                 


Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 
225                 230                 235                 240 


Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 
                245                 250                 255     


Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 
            260                 265                 270         


Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 
        275                 280                 285             


Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 
    290                 295                 300                 


Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 
305                 310                 315                 320 


Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 
                325                 330                 335     


His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 
            340                 345                 350         


Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 
        355                 360                 365             


Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 
    370                 375                 380                 


Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 
385                 390                 395                 400 


Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 
                405                 410                 415     


Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 
            420                 425                 430         


Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 
        435                 440                 445             


Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 
    450                 455                 460                 


Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 
465                 470                 475                 480 


Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 
                485                 490                 495     


Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 
            500                 505                 510         


Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 
        515                 520                 525             


Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 
    530                 535                 540                 


Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 
545                 550                 555                 560 


Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 
                565                 570                 575     


Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 
            580                 585                 590         


Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 
        595                 600                 605             


Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 
    610                 615                 620                 


Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 
625                 630                 635                 640 


His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 
                645                 650                 655     


Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 
            660                 665                 670         


Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 
        675                 680                 685             


Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 
    690                 695                 700                 


Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 
705                 710                 715                 720 


Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 
                725                 730                 735     


Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 
            740                 745                 750         


Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 
        755                 760                 765             


Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 
    770                 775                 780                 


Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 
785                 790                 795                 800 


Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 
                805                 810                 815     


Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 
            820                 825                 830         


Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 
        835                 840                 845             


Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 
    850                 855                 860                 


His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 
865                 870                 875                 880 


Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 
                885                 890                 895     


Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 
            900                 905                 910         


Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 
        915                 920                 925             


Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 
    930                 935                 940                 


Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 
945                 950                 955                 960 


Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 
                965                 970                 975     


Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 
            980                 985                 990         


Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 
        995                 1000                 1005             


Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 
    1010                 1015                 1020             


Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 
    1025                 1030                 1035             


Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 
    1040                 1045                 1050             


Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 
    1055                 1060                 1065             


Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 
    1070                 1075                 1080             


Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 
    1085                 1090                 1095             


Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 
    1100                 1105                 1110             


Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 
    1115                 1120                 1125             


Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 
    1130                 1135                 1140             


Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 
    1145                 1150                 1155             


Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 
    1160                 1165                 1170             


Gly Glu  Tyr Arg Ser Leu Glu  Ser Asp Asn Glu Glu  Lys Ala Phe 
    1175                 1180                 1185             


Gly Ser  Ser Gln Pro Ser Leu  Asn Gly Asp Ile Lys  Pro Leu Gly 
    1190                 1195                 1200             


Ser Asp  Asp Ser Leu Ala Asp  Tyr Gly Gly Ser Val  Asp Val Gln 
    1205                 1210                 1215             


Phe Asn  Glu Asp Gly Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys 
    1220                 1225                 1230             


Glu Lys  Glu Ala Ala Gly Gly  Asn Asp Ser Ser Gly  Ala Thr Ser 
    1235                 1240                 1245             


Pro Ile  Asn Pro Ala Val Ala  Leu Glu 
    1250                 1255         


<210>  277
<211>  1248
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Leu Met Glu Pro Pro Val Ile 
            20                  25                  30          


Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe Pro Thr Asp Asp Ile 
        35                  40                  45              


Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu Val Gln Phe Arg Trp 
    50                  55                  60                  


Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu Glu Leu Gly Val Thr 
65                  70                  75                  80  


Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr Ile Thr Gly Asn Asn 
                85                  90                  95      


Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile Arg Leu Met Ala Glu 
        115                 120                 125             


Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys Pro Val Glu Val Glu 
    130                 135                 140                 


Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro Pro Pro Ser Ala Glu 
145                 150                 155                 160 


Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile Leu His Ile Lys Gln 
                165                 170                 175     


Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile Cys His Ala His Phe 
        195                 200                 205             


Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro Ile Asp Leu Arg Val 
    210                 215                 220                 


Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro Arg Leu Leu Phe Pro 
225                 230                 235                 240 


Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln Gly Gln Pro Leu Val 
                245                 250                 255     


Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro Thr Ile Lys Trp Leu 
            260                 265                 270         


Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val Thr Tyr Gln Asn His 
        275                 280                 285             


Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu Glu Asp Asp Gly Glu 
    290                 295                 300                 


Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser Ala Arg His Ala Tyr 
305                 310                 315                 320 


Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu His Lys Pro Gln Ser 
                325                 330                 335     


His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu Asp Cys Gln Val Gln 
            340                 345                 350         


Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile Asn Gly Ile Pro Val 
        355                 360                 365             


Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile Gln Arg Gly Ala Leu 
    370                 375                 380                 


Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met Val Thr Gln Cys Glu 
385                 390                 395                 400 


Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn Ala Tyr Ile Tyr Val 
                405                 410                 415     


Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp Asn Gln Thr Tyr Met 
            420                 425                 430         


Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys Lys Ala Phe Gly Ala 
        435                 440                 445             


Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp Gly Thr Thr Val Leu 
    450                 455                 460                 


Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly Thr Leu Gly Ile Arg 
465                 470                 475                 480 


Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe Cys Leu Ala Ala Asn 
                485                 490                 495     


Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu Lys Val Lys Asp Ala 
            500                 505                 510         


Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile Glu Lys Lys Gly Ser 
        515                 520                 525             


Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp Pro Ser Leu Gln Pro 
    530                 535                 540                 


Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu Gln Glu Leu Gly Asp 
545                 550                 555                 560 


Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu Val Ile His Ser Leu 
                565                 570                 575     


Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val Ala Ser Thr Glu Leu 
            580                 585                 590         


Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val Val Gly Ser Pro Gly 
        595                 600                 605             


Pro Val Pro Arg Leu Val Leu Ser Asp Leu His Leu Leu Thr Gln Ser 
    610                 615                 620                 


Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp His Asn Ala Pro Ile 
625                 630                 635                 640 


Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu Met Ala Pro Glu Lys 
                645                 650                 655     


Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln Thr Ser Thr Thr Leu 
            660                 665                 670         


Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg Val Thr Ala Ile Asn 
        675                 680                 685             


Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser Glu Thr Val Val Thr 
    690                 695                 700                 


Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp Val Lys Gly Glu Gly 
705                 710                 715                 720 


Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys Pro Leu Arg Trp Met 
                725                 730                 735     


Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val Gln Trp Arg Pro Gln 
            740                 745                 750         


Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val Ser Asp Pro Phe Leu 
        755                 760                 765             


Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr Glu Ile Lys Val Gln 
    770                 775                 780                 


Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro Gln Val Thr Ile Gly 
785                 790                 795                 800 


Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro Glu Leu Glu Gly Ile 
                805                 810                 815     


Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys Trp Arg Pro Val Asp 
            820                 825                 830         


Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr Asn Val Thr Tyr Trp 
        835                 840                 845             


Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg His Ile His Lys Asp 
    850                 855                 860                 


His Val Val Val Pro Ala Asn Thr Thr Ser Val Ile Leu Ser Gly Leu 
865                 870                 875                 880 


Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln Ala Phe Asn Gly Arg 
                885                 890                 895     


Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser Thr Pro Glu Gly Val 
            900                 905                 910         


Pro Gly His Pro Glu Ala Leu His Leu Glu Cys Gln Ser Asn Thr Ser 
        915                 920                 925             


Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His Asn Gly Val Leu Thr 
    930                 935                 940                 


Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu Gly Gly Lys Gly Gln 
945                 950                 955                 960 


Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg Thr His Asn Leu Thr 
                965                 970                 975     


Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln Leu Gln Ala Thr Thr 
            980                 985                 990         


Lys Glu Gly Pro Gly Glu Ala Ile  Val Arg Glu Gly Gly  Thr Met Ala 
        995                 1000                 1005             


Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile Ser Ala  Thr Ala Gly 
    1010                 1015                 1020             


Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro Lys Glu  Gly Gln Cys 
    1025                 1030                 1035             


Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala Leu Gly  Glu Glu Lys 
    1040                 1045                 1050             


Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val Ser Tyr  Asn Gln Ser 
    1055                 1060                 1065             


Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp Thr Asp  Tyr Glu Ile 
    1070                 1075                 1080             


His Leu  Phe Lys Glu Arg Met  Phe Arg His Gln Met  Ala Val Lys 
    1085                 1090                 1095             


Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro Pro Ala  Gly Phe Ala 
    1100                 1105                 1110             


Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser Ala Ile  Ile Leu Leu 
    1115                 1120                 1125             


Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile Lys Arg  Ser Lys Gly 
    1130                 1135                 1140             


Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp Thr Gln  Val Asp Ser 
    1145                 1150                 1155             


Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe Gly Glu  Tyr Ser Asp 
    1160                 1165                 1170             


Asn Glu  Glu Lys Ala Phe Gly  Ser Ser Gln Pro Ser  Leu Asn Gly 
    1175                 1180                 1185             


Asp Ile  Lys Pro Leu Gly Ser  Asp Asp Ser Leu Ala  Asp Tyr Gly 
    1190                 1195                 1200             


Gly Ser  Val Asp Val Gln Phe  Asn Glu Asp Gly Ser  Phe Ile Gly 
    1205                 1210                 1215             


Gln Tyr  Ser Gly Lys Lys Glu  Lys Glu Ala Ala Gly  Gly Asn Asp 
    1220                 1225                 1230             


Ser Ser  Gly Ala Thr Ser Pro  Ile Asn Pro Ala Val  Ala Leu Glu 
    1235                 1240                 1245             


<210>  278
<211>  1257
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 
                85                  90                  95      


Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 
            100                 105                 110         


Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 
        115                 120                 125             


Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 
    130                 135                 140                 


Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 
145                 150                 155                 160 


Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 
                165                 170                 175     


Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 
            180                 185                 190         


Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 
        195                 200                 205             


Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 
    210                 215                 220                 


Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 
225                 230                 235                 240 


Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 
                245                 250                 255     


Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 
            260                 265                 270         


Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 
        275                 280                 285             


Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 
    290                 295                 300                 


Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 
305                 310                 315                 320 


Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 
                325                 330                 335     


His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 
            340                 345                 350         


Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 
        355                 360                 365             


Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 
    370                 375                 380                 


Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 
385                 390                 395                 400 


Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 
                405                 410                 415     


Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 
            420                 425                 430         


Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 
        435                 440                 445             


Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 
    450                 455                 460                 


Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 
465                 470                 475                 480 


Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 
                485                 490                 495     


Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 
            500                 505                 510         


Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 
        515                 520                 525             


Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 
    530                 535                 540                 


Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 
545                 550                 555                 560 


Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 
                565                 570                 575     


Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 
            580                 585                 590         


Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 
        595                 600                 605             


Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 
    610                 615                 620                 


Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 
625                 630                 635                 640 


His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 
                645                 650                 655     


Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 
            660                 665                 670         


Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 
        675                 680                 685             


Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 
    690                 695                 700                 


Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 
705                 710                 715                 720 


Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 
                725                 730                 735     


Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 
            740                 745                 750         


Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 
        755                 760                 765             


Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 
    770                 775                 780                 


Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 
785                 790                 795                 800 


Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 
                805                 810                 815     


Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 
            820                 825                 830         


Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 
        835                 840                 845             


Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 
    850                 855                 860                 


His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 
865                 870                 875                 880 


Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 
                885                 890                 895     


Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 
            900                 905                 910         


Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 
        915                 920                 925             


Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 
    930                 935                 940                 


Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 
945                 950                 955                 960 


Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 
                965                 970                 975     


Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 
            980                 985                 990         


Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 
        995                 1000                 1005             


Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 
    1010                 1015                 1020             


Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 
    1025                 1030                 1035             


Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 
    1040                 1045                 1050             


Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 
    1055                 1060                 1065             


Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 
    1070                 1075                 1080             


Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 
    1085                 1090                 1095             


Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 
    1100                 1105                 1110             


Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 
    1115                 1120                 1125             


Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 
    1130                 1135                 1140             


Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 
    1145                 1150                 1155             


Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 
    1160                 1165                 1170             


Gly Glu  Tyr Arg Ser Leu Glu  Ser Asp Asn Glu Glu  Lys Ala Phe 
    1175                 1180                 1185             


Gly Ser  Ser Gln Pro Ser Leu  Asn Gly Asp Ile Lys  Pro Leu Gly 
    1190                 1195                 1200             


Ser Asp  Asp Ser Leu Ala Asp  Tyr Gly Gly Ser Val  Asp Val Gln 
    1205                 1210                 1215             


Phe Asn  Glu Asp Gly Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys 
    1220                 1225                 1230             


Glu Lys  Glu Ala Ala Gly Gly  Asn Asp Ser Ser Gly  Ala Thr Ser 
    1235                 1240                 1245             


Pro Ile  Asn Pro Ala Val Ala  Leu Glu 
    1250                 1255         


<210>  279
<211>  1253
<212>  PRT
<213>  Homo sapiens

<400>  279

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 
                85                  90                  95      


Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 
            100                 105                 110         


Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 
        115                 120                 125             


Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 
    130                 135                 140                 


Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 
145                 150                 155                 160 


Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 
                165                 170                 175     


Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 
            180                 185                 190         


Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 
        195                 200                 205             


Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 
    210                 215                 220                 


Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 
225                 230                 235                 240 


Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 
                245                 250                 255     


Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 
            260                 265                 270         


Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 
        275                 280                 285             


Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 
    290                 295                 300                 


Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 
305                 310                 315                 320 


Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 
                325                 330                 335     


His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 
            340                 345                 350         


Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 
        355                 360                 365             


Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 
    370                 375                 380                 


Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 
385                 390                 395                 400 


Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 
                405                 410                 415     


Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 
            420                 425                 430         


Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 
        435                 440                 445             


Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 
    450                 455                 460                 


Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 
465                 470                 475                 480 


Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 
                485                 490                 495     


Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 
            500                 505                 510         


Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 
        515                 520                 525             


Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 
    530                 535                 540                 


Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 
545                 550                 555                 560 


Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 
                565                 570                 575     


Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 
            580                 585                 590         


Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 
        595                 600                 605             


Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 
    610                 615                 620                 


Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 
625                 630                 635                 640 


His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 
                645                 650                 655     


Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 
            660                 665                 670         


Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 
        675                 680                 685             


Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 
    690                 695                 700                 


Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 
705                 710                 715                 720 


Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 
                725                 730                 735     


Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 
            740                 745                 750         


Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 
        755                 760                 765             


Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 
    770                 775                 780                 


Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 
785                 790                 795                 800 


Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 
                805                 810                 815     


Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 
            820                 825                 830         


Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 
        835                 840                 845             


Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 
    850                 855                 860                 


His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 
865                 870                 875                 880 


Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 
                885                 890                 895     


Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 
            900                 905                 910         


Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 
        915                 920                 925             


Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 
    930                 935                 940                 


Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 
945                 950                 955                 960 


Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 
                965                 970                 975     


Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 
            980                 985                 990         


Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 
        995                 1000                 1005             


Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 
    1010                 1015                 1020             


Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 
    1025                 1030                 1035             


Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 
    1040                 1045                 1050             


Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 
    1055                 1060                 1065             


Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 
    1070                 1075                 1080             


Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 
    1085                 1090                 1095             


Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 
    1100                 1105                 1110             


Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 
    1115                 1120                 1125             


Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 
    1130                 1135                 1140             


Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 
    1145                 1150                 1155             


Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 
    1160                 1165                 1170             


Gly Glu  Tyr Ser Asp Asn Glu  Glu Lys Ala Phe Gly  Ser Ser Gln 
    1175                 1180                 1185             


Pro Ser  Leu Asn Gly Asp Ile  Lys Pro Leu Gly Ser  Asp Asp Ser 
    1190                 1195                 1200             


Leu Ala  Asp Tyr Gly Gly Ser  Val Asp Val Gln Phe  Asn Glu Asp 
    1205                 1210                 1215             


Gly Ser  Phe Ile Gly Gln Tyr  Ser Gly Lys Lys Glu  Lys Glu Ala 
    1220                 1225                 1230             


Ala Gly  Gly Asn Asp Ser Ser  Gly Ala Thr Ser Pro  Ile Asn Pro 
    1235                 1240                 1245             


Ala Val  Ala Leu Glu 
    1250             


<210>  280
<211>  1097
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Met Asp Ile Tyr Val Cys Leu Lys Arg Pro Ser Trp Met Val Asp 
1               5                   10                  15      


Asn Lys Arg Met Arg Thr Ala Ser Asn Phe Gln Trp Leu Leu Ser Thr 
            20                  25                  30          


Phe Ile Leu Leu Tyr Leu Met Asn Gln Val Asn Ser Gln Lys Lys Gly 
        35                  40                  45              


Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Gln Val Trp Asn 
    50                  55                  60                  


Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly Thr Asp Tyr Glu 
65                  70                  75                  80  


Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln Leu Glu Lys Thr 
                85                  90                  95      


Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr Glu Ile Thr Ile 
            100                 105                 110         


Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys Phe Thr Leu Asn 
        115                 120                 125             


Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu Ile Leu Asn Leu 
    130                 135                 140                 


Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys Trp Asn Asp Arg 
145                 150                 155                 160 


Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp Glu Ile Lys Val 
                165                 170                 175     


Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val Thr His Asn Thr 
            180                 185                 190         


Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser Trp Ala Ser Asp 
        195                 200                 205             


Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile Arg Cys Tyr Ile 
    210                 215                 220                 


Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser Asp Trp Ser Pro 
225                 230                 235                 240 


Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr Lys Val Phe Pro 
                245                 250                 255     


Gln Asp Lys Val Ile Leu Val Gly Ser Asp Ile Thr Phe Cys Cys Val 
            260                 265                 270         


Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly His Thr Asn Cys Pro 
        275                 280                 285             


Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys Ile Arg Asn Ile 
    290                 295                 300                 


Ser Val Ser Ala Ser Ser Gly Thr Asn Val Val Phe Thr Thr Glu Asp 
305                 310                 315                 320 


Asn Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro Pro Asp Thr Pro 
                325                 330                 335     


Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu Ile Ile Cys Ser 
            340                 345                 350         


Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro Arg Ala Thr Ser 
        355                 360                 365             


Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val Arg Leu Lys Arg 
    370                 375                 380                 


Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu Phe Gln Met Leu 
385                 390                 395                 400 


Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala His Asn Pro Leu 
                405                 410                 415     


Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr Glu Lys Val Tyr 
            420                 425                 430         


Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile Asn Ser Thr Ala 
        435                 440                 445             


Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala Lys Ile Asn Phe 
    450                 455                 460                 


Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val Gln Glu Gln Arg 
465                 470                 475                 480 


Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr Leu Val Ala Leu 
                485                 490                 495     


Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg Ile Arg Cys Ser 
            500                 505                 510         


Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn Lys Lys Gln His 
        515                 520                 525             


Leu Thr Thr Glu Ala Ser Pro Ser Lys Gly Pro Asp Thr Trp Arg Glu 
    530                 535                 540                 


Trp Ser Ser Asp Gly Lys Asn Leu Ile Ile Tyr Trp Lys Pro Leu Pro 
545                 550                 555                 560 


Ile Asn Glu Ala Asn Gly Lys Ile Leu Ser Tyr Asn Val Ser Cys Ser 
                565                 570                 575     


Ser Asp Glu Glu Thr Gln Ser Leu Ser Glu Ile Pro Asp Pro Gln His 
            580                 585                 590         


Lys Ala Glu Ile Arg Leu Asp Lys Asn Asp Tyr Ile Ile Ser Val Val 
        595                 600                 605             


Ala Lys Asn Ser Val Gly Ser Ser Pro Pro Ser Lys Ile Ala Ser Met 
    610                 615                 620                 


Glu Ile Pro Asn Asp Asp Leu Lys Ile Glu Gln Val Val Gly Met Gly 
625                 630                 635                 640 


Lys Gly Ile Leu Leu Thr Trp His Tyr Asp Pro Asn Met Thr Cys Asp 
                645                 650                 655     


Tyr Val Ile Lys Trp Cys Asn Ser Ser Arg Ser Glu Pro Cys Leu Met 
            660                 665                 670         


Asp Trp Arg Lys Val Pro Ser Asn Ser Thr Glu Thr Val Ile Glu Ser 
        675                 680                 685             


Asp Glu Phe Arg Pro Gly Ile Arg Tyr Asn Phe Phe Leu Tyr Gly Cys 
    690                 695                 700                 


Arg Asn Gln Gly Tyr Gln Leu Leu Arg Ser Met Ile Gly Tyr Ile Glu 
705                 710                 715                 720 


Glu Leu Ala Pro Ile Val Ala Pro Asn Phe Thr Val Glu Asp Thr Ser 
                725                 730                 735     


Ala Asp Ser Ile Leu Val Lys Trp Glu Asp Ile Pro Val Glu Glu Leu 
            740                 745                 750         


Arg Gly Phe Leu Arg Gly Tyr Leu Phe Tyr Phe Gly Lys Gly Glu Arg 
        755                 760                 765             


Asp Thr Ser Lys Met Arg Val Leu Glu Ser Gly Arg Ser Asp Ile Lys 
    770                 775                 780                 


Val Lys Asn Ile Thr Asp Ile Ser Gln Lys Thr Leu Arg Ile Ala Asp 
785                 790                 795                 800 


Leu Gln Gly Lys Thr Ser Tyr His Leu Val Leu Arg Ala Tyr Thr Asp 
                805                 810                 815     


Gly Gly Val Gly Pro Glu Lys Ser Met Tyr Val Val Thr Lys Glu Asn 
            820                 825                 830         


Ser Val Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val 
        835                 840                 845             


Ile Val Gly Val Val Thr Ser Ile Leu Cys Tyr Arg Lys Arg Glu Trp 
    850                 855                 860                 


Ile Lys Glu Thr Phe Tyr Pro Asp Ile Pro Asn Pro Glu Asn Cys Lys 
865                 870                 875                 880 


Ala Leu Gln Phe Gln Lys Ser Val Cys Glu Gly Ser Ser Ala Leu Lys 
                885                 890                 895     


Thr Leu Glu Met Asn Pro Cys Thr Pro Asn Asn Val Glu Val Leu Glu 
            900                 905                 910         


Thr Arg Ser Ala Phe Pro Lys Ile Glu Asp Thr Glu Ile Ile Ser Pro 
        915                 920                 925             


Val Ala Glu Arg Pro Glu Asp Arg Ser Asp Ala Glu Pro Glu Asn His 
    930                 935                 940                 


Val Val Val Ser Tyr Cys Pro Pro Ile Ile Glu Glu Glu Ile Pro Asn 
945                 950                 955                 960 


Pro Ala Ala Asp Glu Ala Gly Gly Thr Ala Gln Val Ile Tyr Ile Asp 
                965                 970                 975     


Val Gln Ser Met Tyr Gln Pro Gln Ala Lys Pro Glu Glu Glu Gln Glu 
            980                 985                 990         


Asn Asp Pro Val Gly Gly Ala Gly  Tyr Lys Pro Gln Met  His Leu Pro 
        995                 1000                 1005             


Ile Asn  Ser Thr Val Glu Asp  Ile Ala Ala Glu Glu  Asp Leu Asp 
    1010                 1015                 1020             


Lys Thr  Ala Gly Tyr Arg Pro  Gln Ala Asn Val Asn  Thr Trp Asn 
    1025                 1030                 1035             


Leu Val  Ser Pro Asp Ser Pro  Arg Ser Ile Asp Ser  Asn Ser Glu 
    1040                 1045                 1050             


Ile Val  Ser Phe Gly Ser Pro  Cys Ser Ile Asn Ser  Arg Gln Phe 
    1055                 1060                 1065             


Leu Ile  Pro Pro Lys Asp Glu  Asp Ser Pro Lys Ser  Asn Gly Gly 
    1070                 1075                 1080             


Gly Trp  Ser Phe Thr Asn Phe  Phe Gln Asn Lys Pro  Asn Asp 
    1085                 1090                 1095         


<210>  281
<211>  1097
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Met Asp Ile Tyr Val Cys Leu Lys Arg Pro Ser Trp Met Val Asp 
1               5                   10                  15      


Asn Lys Arg Met Arg Thr Ala Ser Asn Phe Gln Trp Leu Leu Ser Thr 
            20                  25                  30          


Phe Ile Leu Leu Tyr Leu Met Asn Gln Val Asn Ser Gln Lys Lys Gly 
        35                  40                  45              


Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Gln Val Trp Asn 
    50                  55                  60                  


Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly Thr Asp Tyr Glu 
65                  70                  75                  80  


Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln Leu Glu Lys Thr 
                85                  90                  95      


Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr Glu Ile Thr Ile 
            100                 105                 110         


Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys Phe Thr Leu Asn 
        115                 120                 125             


Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu Ile Leu Asn Leu 
    130                 135                 140                 


Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys Trp Asn Asp Arg 
145                 150                 155                 160 


Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp Glu Ile Lys Val 
                165                 170                 175     


Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val Thr His Asn Thr 
            180                 185                 190         


Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser Trp Ala Ser Asp 
        195                 200                 205             


Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile Arg Cys Tyr Ile 
    210                 215                 220                 


Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser Asp Trp Ser Pro 
225                 230                 235                 240 


Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr Lys Val Phe Pro 
                245                 250                 255     


Gln Asp Lys Val Ile Leu Val Gly Ser Asp Ile Thr Phe Cys Cys Val 
            260                 265                 270         


Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly His Thr Asn Cys Pro 
        275                 280                 285             


Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys Ile Arg Asn Ile 
    290                 295                 300                 


Ser Val Ser Ala Ser Ser Gly Thr Asn Val Val Phe Thr Thr Glu Asp 
305                 310                 315                 320 


Asn Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro Pro Asp Thr Pro 
                325                 330                 335     


Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu Ile Ile Cys Ser 
            340                 345                 350         


Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro Arg Ala Thr Ser 
        355                 360                 365             


Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val Arg Leu Lys Arg 
    370                 375                 380                 


Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu Phe Gln Met Leu 
385                 390                 395                 400 


Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala His Asn Pro Leu 
                405                 410                 415     


Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr Glu Lys Val Tyr 
            420                 425                 430         


Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile Asn Ser Thr Ala 
        435                 440                 445             


Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala Lys Ile Asn Phe 
    450                 455                 460                 


Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val Gln Glu Gln Arg 
465                 470                 475                 480 


Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr Leu Val Ala Leu 
                485                 490                 495     


Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg Ile Arg Cys Ser 
            500                 505                 510         


Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn Lys Lys Gln His 
        515                 520                 525             


Leu Thr Thr Glu Ala Ser Pro Ser Lys Gly Pro Asp Thr Trp Arg Glu 
    530                 535                 540                 


Trp Ser Ser Asp Gly Lys Asn Leu Ile Ile Tyr Trp Lys Pro Leu Pro 
545                 550                 555                 560 


Ile Asn Glu Ala Asn Gly Lys Ile Leu Ser Tyr Asn Val Ser Cys Ser 
                565                 570                 575     


Ser Asp Glu Glu Thr Gln Ser Leu Ser Glu Ile Pro Asp Pro Gln His 
            580                 585                 590         


Lys Ala Glu Ile Arg Leu Asp Lys Asn Asp Tyr Ile Ile Ser Val Val 
        595                 600                 605             


Ala Lys Asn Ser Val Gly Ser Ser Pro Pro Ser Lys Ile Ala Ser Met 
    610                 615                 620                 


Glu Ile Pro Asn Asp Asp Leu Lys Ile Glu Gln Val Val Gly Met Gly 
625                 630                 635                 640 


Lys Gly Ile Leu Leu Thr Trp His Tyr Asp Pro Asn Met Thr Cys Asp 
                645                 650                 655     


Tyr Val Ile Lys Trp Cys Asn Ser Ser Arg Ser Glu Pro Cys Leu Met 
            660                 665                 670         


Asp Trp Arg Lys Val Pro Ser Asn Ser Thr Glu Thr Val Ile Glu Ser 
        675                 680                 685             


Asp Glu Phe Arg Pro Gly Ile Arg Tyr Asn Phe Phe Leu Tyr Gly Cys 
    690                 695                 700                 


Arg Asn Gln Gly Tyr Gln Leu Leu Arg Ser Met Ile Gly Tyr Ile Glu 
705                 710                 715                 720 


Glu Leu Ala Pro Ile Val Ala Pro Asn Phe Thr Val Glu Asp Thr Ser 
                725                 730                 735     


Ala Asp Ser Ile Leu Val Lys Trp Glu Asp Ile Pro Val Glu Glu Leu 
            740                 745                 750         


Arg Gly Phe Leu Arg Gly Tyr Leu Phe Tyr Phe Gly Lys Gly Glu Arg 
        755                 760                 765             


Asp Thr Ser Lys Met Arg Val Leu Glu Ser Gly Arg Ser Asp Ile Lys 
    770                 775                 780                 


Val Lys Asn Ile Thr Asp Ile Ser Gln Lys Thr Leu Arg Ile Ala Asp 
785                 790                 795                 800 


Leu Gln Gly Lys Thr Ser Tyr His Leu Val Leu Arg Ala Tyr Thr Asp 
                805                 810                 815     


Gly Gly Val Gly Pro Glu Lys Ser Met Tyr Val Val Thr Lys Glu Asn 
            820                 825                 830         


Ser Val Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val 
        835                 840                 845             


Ile Val Gly Val Val Thr Ser Ile Leu Cys Tyr Arg Lys Arg Glu Trp 
    850                 855                 860                 


Ile Lys Glu Thr Phe Tyr Pro Asp Ile Pro Asn Pro Glu Asn Cys Lys 
865                 870                 875                 880 


Ala Leu Gln Phe Gln Lys Ser Val Cys Glu Gly Ser Ser Ala Leu Lys 
                885                 890                 895     


Thr Leu Glu Met Asn Pro Cys Thr Pro Asn Asn Val Glu Val Leu Glu 
            900                 905                 910         


Thr Arg Ser Ala Phe Pro Lys Ile Glu Asp Thr Glu Ile Ile Ser Pro 
        915                 920                 925             


Val Ala Glu Arg Pro Glu Asp Arg Ser Asp Ala Glu Pro Glu Asn His 
    930                 935                 940                 


Val Val Val Ser Tyr Cys Pro Pro Ile Ile Glu Glu Glu Ile Pro Asn 
945                 950                 955                 960 


Pro Ala Ala Asp Glu Ala Gly Gly Thr Ala Gln Val Ile Tyr Ile Asp 
                965                 970                 975     


Val Gln Ser Met Tyr Gln Pro Gln Ala Lys Pro Glu Glu Glu Gln Glu 
            980                 985                 990         


Asn Asp Pro Val Gly Gly Ala Gly  Tyr Lys Pro Gln Met  His Leu Pro 
        995                 1000                 1005             


Ile Asn  Ser Thr Val Glu Asp  Ile Ala Ala Glu Glu  Asp Leu Asp 
    1010                 1015                 1020             


Lys Thr  Ala Gly Tyr Arg Pro  Gln Ala Asn Val Asn  Thr Trp Asn 
    1025                 1030                 1035             


Leu Val  Ser Pro Asp Ser Pro  Arg Ser Ile Asp Ser  Asn Ser Glu 
    1040                 1045                 1050             


Ile Val  Ser Phe Gly Ser Pro  Cys Ser Ile Asn Ser  Arg Gln Phe 
    1055                 1060                 1065             


Leu Ile  Pro Pro Lys Asp Glu  Asp Ser Pro Lys Ser  Asn Gly Gly 
    1070                 1075                 1080             


Gly Trp  Ser Phe Thr Asn Phe  Phe Gln Asn Lys Pro  Asn Asp 
    1085                 1090                 1095         


<210>  282
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  283
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  284
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  285
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  286
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  287
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  288
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  289
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  290
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  291
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  291

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  292
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  293
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Gln Val Ser Lys Arg Met Leu Ala Gly Gly Val Arg Ser Met Pro 
1               5                   10                  15      


Ser Pro Leu Leu Ala Cys Trp Gln Pro Ile Leu Leu Leu Val Leu Gly 
            20                  25                  30          


Ser Val Leu Ser Gly Ser Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys 
        35                  40                  45              


Ser Ala Gln Asp Arg Ala Val Leu Cys His Arg Lys Arg Phe Val Ala 
    50                  55                  60                  


Val Pro Glu Gly Ile Pro Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys 
65                  70                  75                  80  


Asn Arg Ile Lys Thr Leu Asn Gln Asp Glu Phe Ala Ser Phe Pro His 
                85                  90                  95      


Leu Glu Glu Leu Glu Leu Asn Glu Asn Ile Val Ser Ala Val Glu Pro 
            100                 105                 110         


Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser 
        115                 120                 125             


Asn Arg Leu Lys Leu Ile Pro Leu Gly Val Phe Thr Gly Leu Ser Asn 
    130                 135                 140                 


Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu Leu Asp 
145                 150                 155                 160 


Tyr Met Phe Gln Asp Leu Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp 
                165                 170                 175     


Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu Asn Ser 
            180                 185                 190         


Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr 
        195                 200                 205             


Glu Ala Leu Ser His Leu His Gly Leu Ile Val Leu Arg Leu Arg His 
    210                 215                 220                 


Leu Asn Ile Asn Ala Ile Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg 
225                 230                 235                 240 


Leu Lys Val Leu Glu Ile Ser His Trp Pro Tyr Leu Asp Thr Met Thr 
                245                 250                 255     


Pro Asn Cys Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Ile Thr His 
            260                 265                 270         


Cys Asn Leu Thr Ala Val Pro Tyr Leu Ala Val Arg His Leu Val Tyr 
        275                 280                 285             


Leu Arg Phe Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly 
    290                 295                 300                 


Ser Met Leu His Glu Leu Leu Arg Leu Gln Glu Ile Gln Leu Val Gly 
305                 310                 315                 320 


Gly Gln Leu Ala Val Val Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr 
                325                 330                 335     


Leu Arg Val Leu Asn Val Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu 
            340                 345                 350         


Ser Val Phe His Ser Val Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser 
        355                 360                 365             


Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Val Phe Arg Arg Arg 
    370                 375                 380                 


Trp Arg Leu Asn Phe Asn Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu 
385                 390                 395                 400 


Phe Val Gln Gly Lys Glu Phe Lys Asp Phe Pro Asp Val Leu Leu Pro 
                405                 410                 415     


Asn Tyr Phe Thr Cys Arg Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln 
            420                 425                 430         


Gln Val Phe Val Asp Glu Gly His Thr Val Gln Phe Val Cys Arg Ala 
        435                 440                 445             


Asp Gly Asp Pro Pro Pro Ala Ile Leu Trp Leu Ser Pro Arg Lys His 
    450                 455                 460                 


Leu Val Ser Ala Lys Ser Asn Gly Arg Leu Thr Val Phe Pro Asp Gly 
465                 470                 475                 480 


Thr Leu Glu Val Arg Tyr Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu 
                485                 490                 495     


Cys Ile Ala Ala Asn Ala Gly Gly Asn Asp Ser Met Pro Ala His Leu 
            500                 505                 510         


His Val Arg Ser Tyr Ser Pro Asp Trp Pro His Gln Pro Asn Lys Thr 
        515                 520                 525             


Phe Ala Phe Ile Ser Asn Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr 
    530                 535                 540                 


Arg Ala Thr Val Pro Phe Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala 
545                 550                 555                 560 


Thr Thr Met Gly Phe Ile Ser Phe Leu Gly Val Val Leu Phe Cys Leu 
                565                 570                 575     


Val Leu Leu Phe Leu Trp Ser Arg Gly Lys Gly Asn Thr Lys His Asn 
            580                 585                 590         


Ile Glu Ile Glu Tyr Val Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser 
        595                 600                 605             


Ala Asp Ala Pro Arg Lys Phe Asn Met Lys Met Ile 
    610                 615                 620 


<210>  294
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Val Ile Met Gly Gln Cys Tyr Tyr Asn Glu Thr Ile Gly Phe Phe 
1               5                   10                  15      


Tyr Asn Asn Ser Gly Lys Glu Leu Ser Ser His Trp Arg Pro Lys Asp 
            20                  25                  30          


Val Val Val Val Ala Leu Gly Leu Thr Val Ser Val Leu Val Leu Leu 
        35                  40                  45              


Thr Asn Leu Leu Val Ile Ala Ala Ile Ala Ser Asn Arg Arg Phe His 
    50                  55                  60                  


Gln Pro Ile Tyr Tyr Leu Leu Gly Asn Leu Ala Ala Ala Asp Leu Phe 
65                  70                  75                  80  


Ala Gly Val Ala Tyr Leu Phe Leu Met Phe His Thr Gly Pro Arg Thr 
                85                  90                  95      


Ala Arg Leu Ser Leu Glu Gly Trp Phe Leu Arg Gln Gly Leu Leu Asp 
            100                 105                 110         


Thr Ser Leu Thr Ala Ser Val Ala Thr Leu Leu Ala Ile Ala Val Glu 
        115                 120                 125             


Arg His Arg Ser Val Met Ala Val Gln Leu His Ser Arg Leu Pro Arg 
    130                 135                 140                 


Gly Arg Val Val Met Leu Ile Val Gly Val Trp Val Ala Ala Leu Gly 
145                 150                 155                 160 


Leu Gly Leu Leu Pro Ala His Ser Trp His Cys Leu Cys Ala Leu Asp 
                165                 170                 175     


Arg Cys Ser Arg Met Ala Pro Leu Leu Ser Arg Ser Tyr Leu Ala Val 
            180                 185                 190         


Trp Ala Leu Ser Ser Leu Leu Val Phe Leu Leu Met Val Ala Val Tyr 
        195                 200                 205             


Thr Arg Ile Phe Phe Tyr Val Arg Arg Arg Val Gln Arg Met Ala Glu 
    210                 215                 220                 


His Val Ser Cys His Pro Arg Tyr Arg Glu Thr Thr Leu Ser Leu Val 
225                 230                 235                 240 


Lys Thr Val Val Ile Ile Leu Gly Ala Phe Val Val Cys Trp Thr Pro 
                245                 250                 255     


Gly Gln Val Val Leu Leu Leu Asp Gly Leu Gly Cys Glu Ser Cys Asn 
            260                 265                 270         


Val Leu Ala Val Glu Lys Tyr Phe Leu Leu Leu Ala Glu Ala Asn Ser 
        275                 280                 285             


Leu Val Asn Ala Ala Val Tyr Ser Cys Arg Asp Ala Glu Met Arg Arg 
    290                 295                 300                 


Thr Phe Arg Arg Leu Leu Cys Cys Ala Cys Leu Arg Gln Ser Thr Arg 
305                 310                 315                 320 


Glu Ser Val His Tyr Thr Ser Ser Ala Gln Gly Gly Ala Ser Thr Arg 
                325                 330                 335     


Ile Met Leu Pro Glu Asn Gly His Pro Leu Met Asp Ser Thr Leu 
            340                 345                 350     


<210>  295
<211>  4655
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp 
        515                 520                 525             


Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp 
    530                 535                 540                 


Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala 
545                 550                 555                 560 


Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser 
                565                 570                 575     


Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys 
            580                 585                 590         


Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser 
        595                 600                 605             


Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val 
    610                 615                 620                 


Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln 
625                 630                 635                 640 


Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln 
                645                 650                 655     


Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln 
            660                 665                 670         


Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg 
        675                 680                 685             


Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys 
    690                 695                 700                 


Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg 
705                 710                 715                 720 


Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val 
                725                 730                 735     


Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp 
            740                 745                 750         


Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln 
        755                 760                 765             


Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu 
    770                 775                 780                 


Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp 
785                 790                 795                 800 


Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys 
                805                 810                 815     


Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val 
            820                 825                 830         


Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro 
        835                 840                 845             


Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val 
    850                 855                 860                 


Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala 
865                 870                 875                 880 


Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His 
                885                 890                 895     


Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln 
            900                 905                 910         


Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe 
        915                 920                 925             


Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly 
    930                 935                 940                 


Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu 
945                 950                 955                 960 


Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln 
                965                 970                 975     


Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro 
            980                 985                 990         


Asn Phe Gln Arg Val Cys Gly Cys  Pro Tyr Gly Met Arg  Leu Ala Ser 
        995                 1000                 1005             


Asn His  Leu Thr Cys Glu Gly  Asp Pro Thr Asn Glu  Pro Pro Thr 
    1010                 1015                 1020             


Glu Gln  Cys Gly Leu Phe Ser  Phe Pro Cys Lys Asn  Gly Arg Cys 
    1025                 1030                 1035             


Val Pro  Asn Tyr Tyr Leu Cys  Asp Gly Val Asp Asp  Cys His Asp 
    1040                 1045                 1050             


Asn Ser  Asp Glu Gln Leu Cys  Gly Thr Leu Asn Asn  Thr Cys Ser 
    1055                 1060                 1065             


Ser Ser  Ala Phe Thr Cys Gly  His Gly Glu Cys Ile  Pro Ala His 
    1070                 1075                 1080             


Trp Arg  Cys Asp Lys Arg Asn  Asp Cys Val Asp Gly  Ser Asp Glu 
    1085                 1090                 1095             


His Asn  Cys Pro Thr His Ala  Pro Ala Ser Cys Leu  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Thr  Cys Asp Asn His Gln  Cys Ile Ser Lys Asn  Trp Val Cys 
    1115                 1120                 1125             


Asp Thr  Asp Asn Asp Cys Gly  Asp Gly Ser Asp Glu  Lys Asn Cys 
    1130                 1135                 1140             


Asn Ser  Thr Glu Thr Cys Gln  Pro Ser Gln Phe Asn  Cys Pro Asn 
    1145                 1150                 1155             


His Arg  Cys Ile Asp Leu Ser  Phe Val Cys Asp Gly  Asp Lys Asp 
    1160                 1165                 1170             


Cys Val  Asp Gly Ser Asp Glu  Val Gly Cys Val Leu  Asn Cys Thr 
    1175                 1180                 1185             


Ala Ser  Gln Phe Lys Cys Ala  Ser Gly Asp Lys Cys  Ile Gly Val 
    1190                 1195                 1200             


Thr Asn  Arg Cys Asp Gly Val  Phe Asp Cys Ser Asp  Asn Ser Asp 
    1205                 1210                 1215             


Glu Ala  Gly Cys Pro Thr Arg  Pro Pro Gly Met Cys  His Ser Asp 
    1220                 1225                 1230             


Glu Phe  Gln Cys Gln Glu Asp  Gly Ile Cys Ile Pro  Asn Phe Trp 
    1235                 1240                 1245             


Glu Cys  Asp Gly His Pro Asp  Cys Leu Tyr Gly Ser  Asp Glu His 
    1250                 1255                 1260             


Asn Ala  Cys Val Pro Lys Thr  Cys Pro Ser Ser Tyr  Phe His Cys 
    1265                 1270                 1275             


Asp Asn  Gly Asn Cys Ile His  Arg Ala Trp Leu Cys  Asp Arg Asp 
    1280                 1285                 1290             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Lys Asp Cys  Pro Thr Gln 
    1295                 1300                 1305             


Pro Phe  Arg Cys Pro Ser Trp  Gln Trp Gln Cys Leu  Gly His Asn 
    1310                 1315                 1320             


Ile Cys  Val Asn Leu Ser Val  Val Cys Asp Gly Ile  Phe Asp Cys 
    1325                 1330                 1335             


Pro Asn  Gly Thr Asp Glu Ser  Pro Leu Cys Asn Gly  Asn Ser Cys 
    1340                 1345                 1350             


Ser Asp  Phe Asn Gly Gly Cys  Thr His Glu Cys Val  Gln Glu Pro 
    1355                 1360                 1365             


Phe Gly  Ala Lys Cys Leu Cys  Pro Leu Gly Phe Leu  Leu Ala Asn 
    1370                 1375                 1380             


Asp Ser  Lys Thr Cys Glu Asp  Ile Asp Glu Cys Asp  Ile Leu Gly 
    1385                 1390                 1395             


Ser Cys  Ser Gln His Cys Tyr  Asn Met Arg Gly Ser  Phe Arg Cys 
    1400                 1405                 1410             


Ser Cys  Asp Thr Gly Tyr Met  Leu Glu Ser Asp Gly  Arg Thr Cys 
    1415                 1420                 1425             


Lys Val  Thr Ala Ser Glu Ser  Leu Leu Leu Leu Val  Ala Ser Gln 
    1430                 1435                 1440             


Asn Lys  Ile Ile Ala Asp Ser  Val Thr Ser Gln Val  His Asn Ile 
    1445                 1450                 1455             


Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile Val Ala  Val Asp Phe 
    1460                 1465                 1470             


Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser Asp Ala  Thr Gln Gly 
    1475                 1480                 1485             


Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr Asp Arg  Arg Val Val 
    1490                 1495                 1500             


Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr Ile Ala  Ile Asp Trp 
    1505                 1510                 1515             


Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr Ala Leu  Glu Thr Ile 
    1520                 1525                 1530             


Glu Val  Ser Lys Ile Asp Gly  Ser His Arg Thr Val  Leu Ile Ser 
    1535                 1540                 1545             


Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala Leu Asp  Pro Arg Met 
    1550                 1555                 1560             


Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp Gly His  His Pro Arg 
    1565                 1570                 1575             


Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met Arg Thr  Val Ile Val 
    1580                 1585                 1590             


Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu Thr Ile  Asp Tyr Pro 
    1595                 1600                 1605             


Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr Leu Asp  Tyr Met Asp 
    1610                 1615                 1620             


Phe Cys  Asp Tyr Asn Gly His  His Arg Arg Gln Val  Ile Ala Ser 
    1625                 1630                 1635             


Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu Thr Leu  Phe Glu Asp 
    1640                 1645                 1650             


Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg Arg Val  Met Arg Ala 
    1655                 1660                 1665             


Asn Lys  Trp His Gly Gly Asn  Gln Ser Val Val Met  Tyr Asn Ile 
    1670                 1675                 1680             


Gln Trp  Pro Leu Gly Ile Val  Ala Val His Pro Ser  Lys Gln Pro 
    1685                 1690                 1695             


Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg Cys Ser  His Leu Cys 
    1700                 1705                 1710             


Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr Ser Cys  Val Cys Pro 
    1715                 1720                 1725             


Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu Asn Cys  Leu Arg Asp 
    1730                 1735                 1740             


Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln His Ile  Ile Phe Gly 
    1745                 1750                 1755             


Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn Asp Ala  Met Val Pro 
    1760                 1765                 1770             


Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val Glu Phe  Asp Asp Ala 
    1775                 1780                 1785             


Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro Gly Glu  Ile His Arg 
    1790                 1795                 1800             


Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val Phe Ala  Ser Ile Ser 
    1805                 1810                 1815             


Met Val  Gly Pro Ser Met Asn  Leu Ala Leu Asp Trp  Ile Ser Arg 
    1820                 1825                 1830             


Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln Ser Ile  Glu Val Leu 
    1835                 1840                 1845             


Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys Thr Leu  Ile Ala Asn 
    1850                 1855                 1860             


Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro Ile Gly  Ile Thr Val 
    1865                 1870                 1875             


Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser Asp Gln  Gly Thr Asp 
    1880                 1885                 1890             


Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala Asn Met  Asp Gly Thr 
    1895                 1900                 1905             


Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu Glu His  Leu Glu Cys 
    1910                 1915                 1920             


Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu Tyr Trp  Ala Val Thr 
    1925                 1930                 1935             


Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val Asp Gly  Thr Asp Arg 
    1940                 1945                 1950             


Met Ile  Leu Val His Gln Leu  Ser His Pro Trp Gly  Ile Ala Val 
    1955                 1960                 1965             


His Asp  Ser Phe Leu Tyr Tyr  Thr Asp Glu Gln Tyr  Glu Val Ile 
    1970                 1975                 1980             


Glu Arg  Val Asp Lys Ala Thr  Gly Ala Asn Lys Ile  Val Leu Arg 
    1985                 1990                 1995             


Asp Asn  Val Pro Asn Leu Arg  Gly Leu Gln Val Tyr  His Arg Arg 
    2000                 2005                 2010             


Asn Ala  Ala Glu Ser Ser Asn  Gly Cys Ser Asn Asn  Met Asn Ala 
    2015                 2020                 2025             


Cys Gln  Gln Ile Cys Leu Pro  Val Pro Gly Gly Leu  Phe Ser Cys 
    2030                 2035                 2040             


Ala Cys  Ala Thr Gly Phe Lys  Leu Asn Pro Asp Asn  Arg Ser Cys 
    2045                 2050                 2055             


Ser Pro  Tyr Asn Ser Phe Ile  Val Val Ser Met Leu  Ser Ala Ile 
    2060                 2065                 2070             


Arg Gly  Phe Ser Leu Glu Leu  Ser Asp His Ser Glu  Thr Met Val 
    2075                 2080                 2085             


Pro Val  Ala Gly Gln Gly Arg  Asn Ala Leu His Val  Asp Val Asp 
    2090                 2095                 2100             


Val Ser  Ser Gly Phe Ile Tyr  Trp Cys Asp Phe Ser  Ser Ser Val 
    2105                 2110                 2115             


Ala Ser  Asp Asn Ala Ile Arg  Arg Ile Lys Pro Asp  Gly Ser Ser 
    2120                 2125                 2130             


Leu Met  Asn Ile Val Thr His  Gly Ile Gly Glu Asn  Gly Val Arg 
    2135                 2140                 2145             


Gly Ile  Ala Val Asp Trp Val  Ala Gly Asn Leu Tyr  Phe Thr Asn 
    2150                 2155                 2160             


Ala Phe  Val Ser Glu Thr Leu  Ile Glu Val Leu Arg  Ile Asn Thr 
    2165                 2170                 2175             


Thr Tyr  Arg Arg Val Leu Leu  Lys Val Thr Val Asp  Met Pro Arg 
    2180                 2185                 2190             


His Ile  Val Val Asp Pro Lys  Asn Arg Tyr Leu Phe  Trp Ala Asp 
    2195                 2200                 2205             


Tyr Gly  Gln Arg Pro Lys Ile  Glu Arg Ser Phe Leu  Asp Cys Thr 
    2210                 2215                 2220             


Asn Arg  Thr Val Leu Val Ser  Glu Gly Ile Val Thr  Pro Arg Gly 
    2225                 2230                 2235             


Leu Ala  Val Asp Arg Ser Asp  Gly Tyr Val Tyr Trp  Val Asp Asp 
    2240                 2245                 2250             


Ser Leu  Asp Ile Ile Ala Arg  Ile Arg Ile Asn Gly  Glu Asn Ser 
    2255                 2260                 2265             


Glu Val  Ile Arg Tyr Gly Ser  Arg Tyr Pro Thr Pro  Tyr Gly Ile 
    2270                 2275                 2280             


Thr Val  Phe Glu Asn Ser Ile  Ile Trp Val Asp Arg  Asn Leu Lys 
    2285                 2290                 2295             


Lys Ile  Phe Gln Ala Ser Lys  Glu Pro Glu Asn Thr  Glu Pro Pro 
    2300                 2305                 2310             


Thr Val  Ile Arg Asp Asn Ile  Asn Trp Leu Arg Asp  Val Thr Ile 
    2315                 2320                 2325             


Phe Asp  Lys Gln Val Gln Pro  Arg Ser Pro Ala Glu  Val Asn Asn 
    2330                 2335                 2340             


Asn Pro  Cys Leu Glu Asn Asn  Gly Gly Cys Ser His  Leu Cys Phe 
    2345                 2350                 2355             


Ala Leu  Pro Gly Leu His Thr  Pro Lys Cys Asp Cys  Ala Phe Gly 
    2360                 2365                 2370             


Thr Leu  Gln Ser Asp Gly Lys  Asn Cys Ala Ile Ser  Thr Glu Asn 
    2375                 2380                 2385             


Phe Leu  Ile Phe Ala Leu Ser  Asn Ser Leu Arg Ser  Leu His Leu 
    2390                 2395                 2400             


Asp Pro  Glu Asn His Ser Pro  Pro Phe Gln Thr Ile  Asn Val Glu 
    2405                 2410                 2415             


Arg Thr  Val Met Ser Leu Asp  Tyr Asp Ser Val Ser  Asp Arg Ile 
    2420                 2425                 2430             


Tyr Phe  Thr Gln Asn Leu Ala  Ser Gly Val Gly Gln  Ile Ser Tyr 
    2435                 2440                 2445             


Ala Thr  Leu Ser Ser Gly Ile  His Thr Pro Thr Val  Ile Ala Ser 
    2450                 2455                 2460             


Gly Ile  Gly Thr Ala Asp Gly  Ile Ala Phe Asp Trp  Ile Thr Arg 
    2465                 2470                 2475             


Arg Ile  Tyr Tyr Ser Asp Tyr  Leu Asn Gln Met Ile  Asn Ser Met 
    2480                 2485                 2490             


Ala Glu  Asp Gly Ser Asn Arg  Thr Val Ile Ala Arg  Val Pro Lys 
    2495                 2500                 2505             


Pro Arg  Ala Ile Val Leu Asp  Pro Cys Gln Gly Tyr  Leu Tyr Trp 
    2510                 2515                 2520             


Ala Asp  Trp Asp Thr His Ala  Lys Ile Glu Arg Ala  Thr Leu Gly 
    2525                 2530                 2535             


Gly Asn  Phe Arg Val Pro Ile  Val Asn Ser Ser Leu  Val Met Pro 
    2540                 2545                 2550             


Ser Gly  Leu Thr Leu Asp Tyr  Glu Glu Asp Leu Leu  Tyr Trp Val 
    2555                 2560                 2565             


Asp Ala  Ser Leu Gln Arg Ile  Glu Arg Ser Thr Leu  Thr Gly Val 
    2570                 2575                 2580             


Asp Arg  Glu Val Ile Val Asn  Ala Ala Val His Ala  Phe Gly Leu 
    2585                 2590                 2595             


Thr Leu  Tyr Gly Gln Tyr Ile  Tyr Trp Thr Asp Leu  Tyr Thr Gln 
    2600                 2605                 2610             


Arg Ile  Tyr Arg Ala Asn Lys  Tyr Asp Gly Ser Gly  Gln Ile Ala 
    2615                 2620                 2625             


Met Thr  Thr Asn Leu Leu Ser  Gln Pro Arg Gly Ile  Asn Thr Val 
    2630                 2635                 2640             


Val Lys  Asn Gln Lys Gln Gln  Cys Asn Asn Pro Cys  Glu Gln Phe 
    2645                 2650                 2655             


Asn Gly  Gly Cys Ser His Ile  Cys Ala Pro Gly Pro  Asn Gly Ala 
    2660                 2665                 2670             


Glu Cys  Gln Cys Pro His Glu  Gly Asn Trp Tyr Leu  Ala Asn Asn 
    2675                 2680                 2685             


Arg Lys  His Cys Ile Val Asp  Asn Gly Glu Arg Cys  Gly Ala Ser 
    2690                 2695                 2700             


Ser Phe  Thr Cys Ser Asn Gly  Arg Cys Ile Ser Glu  Glu Trp Lys 
    2705                 2710                 2715             


Cys Asp  Asn Asp Asn Asp Cys  Gly Asp Gly Ser Asp  Glu Met Glu 
    2720                 2725                 2730             


Ser Val  Cys Ala Leu His Thr  Cys Ser Pro Thr Ala  Phe Thr Cys 
    2735                 2740                 2745             


Ala Asn  Gly Arg Cys Val Gln  Tyr Ser Tyr Arg Cys  Asp Tyr Tyr 
    2750                 2755                 2760             


Asn Asp  Cys Gly Asp Gly Ser  Asp Glu Ala Gly Cys  Leu Phe Arg 
    2765                 2770                 2775             


Asp Cys  Asn Ala Thr Thr Glu  Phe Met Cys Asn Asn  Arg Arg Cys 
    2780                 2785                 2790             


Ile Pro  Arg Glu Phe Ile Cys  Asn Gly Val Asp Asn  Cys His Asp 
    2795                 2800                 2805             


Asn Asn  Thr Ser Asp Glu Lys  Asn Cys Pro Asp Arg  Thr Cys Gln 
    2810                 2815                 2820             


Ser Gly  Tyr Thr Lys Cys His  Asn Ser Asn Ile Cys  Ile Pro Arg 
    2825                 2830                 2835             


Val Tyr  Leu Cys Asp Gly Asp  Asn Asp Cys Gly Asp  Asn Ser Asp 
    2840                 2845                 2850             


Glu Asn  Pro Thr Tyr Cys Thr  Thr His Thr Cys Ser  Ser Ser Glu 
    2855                 2860                 2865             


Phe Gln  Cys Ala Ser Gly Arg  Cys Ile Pro Gln His  Trp Tyr Cys 
    2870                 2875                 2880             


Asp Gln  Glu Thr Asp Cys Phe  Asp Ala Ser Asp Glu  Pro Ala Ser 
    2885                 2890                 2895             


Cys Gly  His Ser Glu Arg Thr  Cys Leu Ala Asp Glu  Phe Lys Cys 
    2900                 2905                 2910             


Asp Gly  Gly Arg Cys Ile Pro  Ser Glu Trp Ile Cys  Asp Gly Asp 
    2915                 2920                 2925             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Asp Lys Arg  His Gln Cys 
    2930                 2935                 2940             


Gln Asn  Gln Asn Cys Ser Asp  Ser Glu Phe Leu Cys  Val Asn Asp 
    2945                 2950                 2955             


Arg Pro  Pro Asp Arg Arg Cys  Ile Pro Gln Ser Trp  Val Cys Asp 
    2960                 2965                 2970             


Gly Asp  Val Asp Cys Thr Asp  Gly Tyr Asp Glu Asn  Gln Asn Cys 
    2975                 2980                 2985             


Thr Arg  Arg Thr Cys Ser Glu  Asn Glu Phe Thr Cys  Gly Tyr Gly 
    2990                 2995                 3000             


Leu Cys  Ile Pro Lys Ile Phe  Arg Cys Asp Arg His  Asn Asp Cys 
    3005                 3010                 3015             


Gly Asp  Tyr Ser Asp Glu Arg  Gly Cys Leu Tyr Gln  Thr Cys Gln 
    3020                 3025                 3030             


Gln Asn  Gln Phe Thr Cys Gln  Asn Gly Arg Cys Ile  Ser Lys Thr 
    3035                 3040                 3045             


Phe Val  Cys Asp Glu Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3050                 3055                 3060             


Leu Met  His Leu Cys His Thr  Pro Glu Pro Thr Cys  Pro Pro His 
    3065                 3070                 3075             


Glu Phe  Lys Cys Asp Asn Gly  Arg Cys Ile Glu Met  Met Lys Leu 
    3080                 3085                 3090             


Cys Asn  His Leu Asp Asp Cys  Leu Asp Asn Ser Asp  Glu Lys Gly 
    3095                 3100                 3105             


Cys Gly  Ile Asn Glu Cys His  Asp Pro Ser Ile Ser  Gly Cys Asp 
    3110                 3115                 3120             


His Asn  Cys Thr Asp Thr Leu  Thr Ser Phe Tyr Cys  Ser Cys Arg 
    3125                 3130                 3135             


Pro Gly  Tyr Lys Leu Met Ser  Asp Lys Arg Thr Cys  Val Asp Ile 
    3140                 3145                 3150             


Asp Glu  Cys Thr Glu Met Pro  Phe Val Cys Ser Gln  Lys Cys Glu 
    3155                 3160                 3165             


Asn Val  Ile Gly Ser Tyr Ile  Cys Lys Cys Ala Pro  Gly Tyr Leu 
    3170                 3175                 3180             


Arg Glu  Pro Asp Gly Lys Thr  Cys Arg Gln Asn Ser  Asn Ile Glu 
    3185                 3190                 3195             


Pro Tyr  Leu Ile Phe Ser Asn  Arg Tyr Tyr Leu Arg  Asn Leu Thr 
    3200                 3205                 3210             


Ile Asp  Gly Tyr Phe Tyr Ser  Leu Ile Leu Glu Gly  Leu Asp Asn 
    3215                 3220                 3225             


Val Val  Ala Leu Asp Phe Asp  Arg Val Glu Lys Arg  Leu Tyr Trp 
    3230                 3235                 3240             


Ile Asp  Thr Gln Arg Gln Val  Ile Glu Arg Met Phe  Leu Asn Lys 
    3245                 3250                 3255             


Thr Asn  Lys Glu Thr Ile Ile  Asn His Arg Leu Pro  Ala Ala Glu 
    3260                 3265                 3270             


Ser Leu  Ala Val Asp Trp Val  Ser Arg Lys Leu Tyr  Trp Leu Asp 
    3275                 3280                 3285             


Ala Arg  Leu Asp Gly Leu Phe  Val Ser Asp Leu Asn  Gly Gly His 
    3290                 3295                 3300             


Arg Arg  Met Leu Ala Gln His  Cys Val Asp Ala Asn  Asn Thr Phe 
    3305                 3310                 3315             


Cys Phe  Asp Asn Pro Arg Gly  Leu Ala Leu His Pro  Gln Tyr Gly 
    3320                 3325                 3330             


Tyr Leu  Tyr Trp Ala Asp Trp  Gly His Arg Ala Tyr  Ile Gly Arg 
    3335                 3340                 3345             


Val Gly  Met Asp Gly Thr Asn  Lys Ser Val Ile Ile  Ser Thr Lys 
    3350                 3355                 3360             


Leu Glu  Trp Pro Asn Gly Ile  Thr Ile Asp Tyr Thr  Asn Asp Leu 
    3365                 3370                 3375             


Leu Tyr  Trp Ala Asp Ala His  Leu Gly Tyr Ile Glu  Tyr Ser Asp 
    3380                 3385                 3390             


Leu Glu  Gly His His Arg His  Thr Val Tyr Asp Gly  Ala Leu Pro 
    3395                 3400                 3405             


His Pro  Phe Ala Ile Thr Ile  Phe Glu Asp Thr Ile  Tyr Trp Thr 
    3410                 3415                 3420             


Asp Trp  Asn Thr Arg Thr Val  Glu Lys Gly Asn Lys  Tyr Asp Gly 
    3425                 3430                 3435             


Ser Asn  Arg Gln Thr Leu Val  Asn Thr Thr His Arg  Pro Phe Asp 
    3440                 3445                 3450             


Ile His  Val Tyr His Pro Tyr  Arg Gln Pro Ile Val  Ser Asn Pro 
    3455                 3460                 3465             


Cys Gly  Thr Asn Asn Gly Gly  Cys Ser His Leu Cys  Leu Ile Lys 
    3470                 3475                 3480             


Pro Gly  Gly Lys Gly Phe Thr  Cys Glu Cys Pro Asp  Asp Phe Arg 
    3485                 3490                 3495             


Thr Leu  Gln Leu Ser Gly Ser  Thr Tyr Cys Met Pro  Met Cys Ser 
    3500                 3505                 3510             


Ser Thr  Gln Phe Leu Cys Ala  Asn Asn Glu Lys Cys  Ile Pro Ile 
    3515                 3520                 3525             


Trp Trp  Lys Cys Asp Gly Gln  Lys Asp Cys Ser Asp  Gly Ser Asp 
    3530                 3535                 3540             


Glu Leu  Ala Leu Cys Pro Gln  Arg Phe Cys Arg Leu  Gly Gln Phe 
    3545                 3550                 3555             


Gln Cys  Ser Asp Gly Asn Cys  Thr Ser Pro Gln Thr  Leu Cys Asn 
    3560                 3565                 3570             


Ala His  Gln Asn Cys Pro Asp  Gly Ser Asp Glu Asp  Arg Leu Leu 
    3575                 3580                 3585             


Cys Glu  Asn His His Cys Asp  Ser Asn Glu Trp Gln  Cys Ala Asn 
    3590                 3595                 3600             


Lys Arg  Cys Ile Pro Glu Ser  Trp Gln Cys Asp Thr  Phe Asn Asp 
    3605                 3610                 3615             


Cys Glu  Asp Asn Ser Asp Glu  Asp Ser Ser His Cys  Ala Ser Arg 
    3620                 3625                 3630             


Thr Cys  Arg Pro Gly Gln Phe  Arg Cys Ala Asn Gly  Arg Cys Ile 
    3635                 3640                 3645             


Pro Gln  Ala Trp Lys Cys Asp  Val Asp Asn Asp Cys  Gly Asp His 
    3650                 3655                 3660             


Ser Asp  Glu Pro Ile Glu Glu  Cys Met Ser Ser Ala  His Leu Cys 
    3665                 3670                 3675             


Asp Asn  Phe Thr Glu Phe Ser  Cys Lys Thr Asn Tyr  Arg Cys Ile 
    3680                 3685                 3690             


Pro Lys  Trp Ala Val Cys Asn  Gly Val Asp Asp Cys  Arg Asp Asn 
    3695                 3700                 3705             


Ser Asp  Glu Gln Gly Cys Glu  Glu Arg Thr Cys His  Pro Val Gly 
    3710                 3715                 3720             


Asp Phe  Arg Cys Lys Asn His  His Cys Ile Pro Leu  Arg Trp Gln 
    3725                 3730                 3735             


Cys Asp  Gly Gln Asn Asp Cys  Gly Asp Asn Ser Asp  Glu Glu Asn 
    3740                 3745                 3750             


Cys Ala  Pro Arg Glu Cys Thr  Glu Ser Glu Phe Arg  Cys Val Asn 
    3755                 3760                 3765             


Gln Gln  Cys Ile Pro Ser Arg  Trp Ile Cys Asp His  Tyr Asn Asp 
    3770                 3775                 3780             


Cys Gly  Asp Asn Ser Asp Glu  Arg Asp Cys Glu Met  Arg Thr Cys 
    3785                 3790                 3795             


His Pro  Glu Tyr Phe Gln Cys  Thr Ser Gly His Cys  Val His Ser 
    3800                 3805                 3810             


Glu Leu  Lys Cys Asp Gly Ser  Ala Asp Cys Leu Asp  Ala Ser Asp 
    3815                 3820                 3825             


Glu Ala  Asp Cys Pro Thr Arg  Phe Pro Asp Gly Ala  Tyr Cys Gln 
    3830                 3835                 3840             


Ala Thr  Met Phe Glu Cys Lys  Asn His Val Cys Ile  Pro Pro Tyr 
    3845                 3850                 3855             


Trp Lys  Cys Asp Gly Asp Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3860                 3865                 3870             


Glu Leu  His Leu Cys Leu Asp  Val Pro Cys Asn Ser  Pro Asn Arg 
    3875                 3880                 3885             


Phe Arg  Cys Asp Asn Asn Arg  Cys Ile Tyr Ser His  Glu Val Cys 
    3890                 3895                 3900             


Asn Gly  Val Asp Asp Cys Gly  Asp Gly Thr Asp Glu  Thr Glu Glu 
    3905                 3910                 3915             


His Cys  Arg Lys Pro Thr Pro  Lys Pro Cys Thr Glu  Tyr Glu Tyr 
    3920                 3925                 3930             


Lys Cys  Gly Asn Gly His Cys  Ile Pro His Asp Asn  Val Cys Asp 
    3935                 3940                 3945             


Asp Ala  Asp Asp Cys Gly Asp  Trp Ser Asp Glu Leu  Gly Cys Asn 
    3950                 3955                 3960             


Lys Gly  Lys Glu Arg Thr Cys  Ala Glu Asn Ile Cys  Glu Gln Asn 
    3965                 3970                 3975             


Cys Thr  Gln Leu Asn Glu Gly  Gly Phe Ile Cys Ser  Cys Thr Ala 
    3980                 3985                 3990             


Gly Phe  Glu Thr Asn Val Phe  Asp Arg Thr Ser Cys  Leu Asp Ile 
    3995                 4000                 4005             


Asn Glu  Cys Glu Gln Phe Gly  Thr Cys Pro Gln His  Cys Arg Asn 
    4010                 4015                 4020             


Thr Lys  Gly Ser Tyr Glu Cys  Val Cys Ala Asp Gly  Phe Thr Ser 
    4025                 4030                 4035             


Met Ser  Asp Arg Pro Gly Lys  Arg Cys Ala Ala Glu  Gly Ser Ser 
    4040                 4045                 4050             


Pro Leu  Leu Leu Leu Pro Asp  Asn Val Arg Ile Arg  Lys Tyr Asn 
    4055                 4060                 4065             


Leu Ser  Ser Glu Arg Phe Ser  Glu Tyr Leu Gln Asp  Glu Glu Tyr 
    4070                 4075                 4080             


Ile Gln  Ala Val Asp Tyr Asp  Trp Asp Pro Lys Asp  Ile Gly Leu 
    4085                 4090                 4095             


Ser Val  Val Tyr Tyr Thr Val  Arg Gly Glu Gly Ser  Arg Phe Gly 
    4100                 4105                 4110             


Ala Ile  Lys Arg Ala Tyr Ile  Pro Asn Phe Glu Ser  Gly Arg Asn 
    4115                 4120                 4125             


Asn Leu  Val Gln Glu Val Asp  Leu Lys Leu Lys Tyr  Val Met Gln 
    4130                 4135                 4140             


Pro Asp  Gly Ile Ala Val Asp  Trp Val Gly Arg His  Ile Tyr Trp 
    4145                 4150                 4155             


Ser Asp  Val Lys Asn Lys Arg  Ile Glu Val Ala Lys  Leu Asp Gly 
    4160                 4165                 4170             


Arg Tyr  Arg Lys Trp Leu Ile  Ser Thr Asp Leu Asp  Gln Pro Ala 
    4175                 4180                 4185             


Ala Ile  Ala Val Asn Pro Lys  Leu Gly Leu Met Phe  Trp Thr Asp 
    4190                 4195                 4200             


Trp Gly  Lys Glu Pro Lys Ile  Glu Ser Ala Trp Met  Asn Gly Glu 
    4205                 4210                 4215             


Asp Arg  Asn Ile Leu Val Phe  Glu Asp Leu Gly Trp  Pro Thr Gly 
    4220                 4225                 4230             


Leu Ser  Ile Asp Tyr Leu Asn  Asn Asp Arg Ile Tyr  Trp Ser Asp 
    4235                 4240                 4245             


Phe Lys  Glu Asp Val Ile Glu  Thr Ile Lys Tyr Asp  Gly Thr Asp 
    4250                 4255                 4260             


Arg Arg  Val Ile Ala Lys Glu  Ala Met Asn Pro Tyr  Ser Leu Asp 
    4265                 4270                 4275             


Ile Phe  Glu Asp Gln Leu Tyr  Trp Ile Ser Lys Glu  Lys Gly Glu 
    4280                 4285                 4290             


Val Trp  Lys Gln Asn Lys Phe  Gly Gln Gly Lys Lys  Glu Lys Thr 
    4295                 4300                 4305             


Leu Val  Val Asn Pro Trp Leu  Thr Gln Val Arg Ile  Phe His Gln 
    4310                 4315                 4320             


Leu Arg  Tyr Asn Lys Ser Val  Pro Asn Leu Cys Lys  Gln Ile Cys 
    4325                 4330                 4335             


Ser His  Leu Cys Leu Leu Arg  Pro Gly Gly Tyr Ser  Cys Ala Cys 
    4340                 4345                 4350             


Pro Gln  Gly Ser Ser Phe Ile  Glu Gly Ser Thr Thr  Glu Cys Asp 
    4355                 4360                 4365             


Ala Ala  Ile Glu Leu Pro Ile  Asn Leu Pro Pro Pro  Cys Arg Cys 
    4370                 4375                 4380             


Met His  Gly Gly Asn Cys Tyr  Phe Asp Glu Thr Asp  Leu Pro Lys 
    4385                 4390                 4395             


Cys Lys  Cys Pro Ser Gly Tyr  Thr Gly Lys Tyr Cys  Glu Met Ala 
    4400                 4405                 4410             


Phe Ser  Lys Gly Ile Ser Pro  Gly Thr Thr Ala Val  Ala Val Leu 
    4415                 4420                 4425             


Leu Thr  Ile Leu Leu Ile Val  Val Ile Gly Ala Leu  Ala Ile Ala 
    4430                 4435                 4440             


Gly Phe  Phe His Tyr Arg Arg  Thr Gly Ser Leu Leu  Pro Ala Leu 
    4445                 4450                 4455             


Pro Lys  Leu Pro Ser Leu Ser  Ser Leu Val Lys Pro  Ser Glu Asn 
    4460                 4465                 4470             


Gly Asn  Gly Val Thr Phe Arg  Ser Gly Ala Asp Leu  Asn Met Asp 
    4475                 4480                 4485             


Ile Gly  Val Ser Gly Phe Gly  Pro Glu Thr Ala Ile  Asp Arg Ser 
    4490                 4495                 4500             


Met Ala  Met Ser Glu Asp Phe  Val Met Glu Met Gly  Lys Gln Pro 
    4505                 4510                 4515             


Ile Ile  Phe Glu Asn Pro Met  Tyr Ser Ala Arg Asp  Ser Ala Val 
    4520                 4525                 4530             


Lys Val  Val Gln Pro Ile Gln  Val Thr Val Ser Glu  Asn Val Asp 
    4535                 4540                 4545             


Asn Lys  Asn Tyr Gly Ser Pro  Ile Asn Pro Ser Glu  Ile Val Pro 
    4550                 4555                 4560             


Glu Thr  Asn Pro Thr Ser Pro  Ala Ala Asp Gly Thr  Gln Val Thr 
    4565                 4570                 4575             


Lys Trp  Asn Leu Phe Lys Arg  Lys Ser Lys Gln Thr  Thr Asn Phe 
    4580                 4585                 4590             


Glu Asn  Pro Ile Tyr Ala Gln  Met Glu Asn Glu Gln  Lys Glu Ser 
    4595                 4600                 4605             


Val Ala  Ala Thr Pro Pro Pro  Ser Pro Ser Leu Pro  Ala Lys Pro 
    4610                 4615                 4620             


Lys Pro  Pro Ser Arg Arg Asp  Pro Thr Pro Thr Tyr  Ser Ala Thr 
    4625                 4630                 4635             


Glu Asp  Thr Phe Lys Asp Thr  Ala Asn Leu Val Lys  Glu Asp Ser 
    4640                 4645                 4650             


Glu Val  
    4655 


<210>  296
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Phe Thr Leu Ala Glu Val Ala Ser Leu Asn Asp Ile Gln Pro Thr 
1               5                   10                  15      


Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Met Asp Tyr Leu Ala 
            20                  25                  30          


Val Val Met Leu Met Val Ala Ile Phe Ala Gly Thr Met Gln Leu Thr 
        35                  40                  45              


Lys Asp Gln Val Val Cys Leu Pro Val Leu Pro Ser Pro Val Asn Ser 
    50                  55                  60                  


Lys Ala His Thr Pro Pro Gly Asn Ala Glu Val Thr Thr Asn Ile Pro 
65                  70                  75                  80  


Lys Met Glu Ala Ala Thr Asn Gln Asp Gln Asp Gly Arg Thr Thr Asn 
                85                  90                  95      


Asp Ile Ser Phe Gly Thr Ser Ala Val Thr Pro Asp Ile Pro Leu Arg 
            100                 105                 110         


Ala Thr Tyr Pro Arg Thr Asp Phe Ala Leu Pro Asn Gln Glu Ala Lys 
        115                 120                 125             


Lys Glu Lys Lys Asp Pro Thr Gly Arg Lys Thr Asn Leu Asp Phe Gln 
    130                 135                 140                 


Gln Tyr Val Phe Ile Asn Gln Met Cys Tyr His Leu Ala Leu Pro Trp 
145                 150                 155                 160 


Tyr Ser Lys Tyr Phe Pro Tyr Leu Ala Leu Ile His Thr Ile Ile Leu 
                165                 170                 175     


Met Val Ser Ser Asn Phe Trp Phe Lys Tyr Pro Lys Thr Cys Ser Lys 
            180                 185                 190         


Val Glu His Phe Val Ser Ile Leu Gly Lys Cys Phe Glu Ser Pro Trp 
        195                 200                 205             


Thr Thr Lys Ala Leu Ser Glu Thr Ala Cys Glu Asp Ser Glu Glu Asn 
    210                 215                 220                 


Lys Gln Arg Ile Thr Gly Ala Gln Thr Leu Pro Lys His Val Ser Thr 
225                 230                 235                 240 


Ser Ser Asp Glu Gly Ser Pro Ser Ala Ser Thr Pro Met Ile Asn Lys 
                245                 250                 255     


Thr Gly Phe Lys Phe Ser Ala Glu Lys Pro Val Ile Glu Val Pro Ser 
            260                 265                 270         


Met Thr Ile Leu Asp Lys Lys Asp Gly Glu Gln Ala Lys Ala Leu Phe 
        275                 280                 285             


Glu Lys Val Arg Lys Phe Arg Ala His Val Glu Asp Ser Asp Leu Ile 
    290                 295                 300                 


Tyr Lys Leu Tyr Val Val Gln Thr Val Ile Lys Thr Ala Lys Phe Ile 
305                 310                 315                 320 


Phe Ile Leu Cys Tyr Thr Ala Asn Phe Val Asn Ala Ile Ser Phe Glu 
                325                 330                 335     


His Val Cys Lys Pro Lys Val Glu His Leu Ile Gly Tyr Glu Val Phe 
            340                 345                 350         


Glu Cys Thr His Asn Met Ala Tyr Met Leu Lys Lys Leu Leu Ile Ser 
        355                 360                 365             


Tyr Ile Ser Ile Ile Cys Val Tyr Gly Phe Ile Cys Leu Tyr Thr Leu 
    370                 375                 380                 


Phe Trp Leu Phe Arg Ile Pro Leu Lys Glu Tyr Ser Phe Glu Lys Val 
385                 390                 395                 400 


Arg Glu Glu Ser Ser Phe Ser Asp Ile Pro Asp Val Lys Asn Asp Phe 
                405                 410                 415     


Ala Phe Leu Leu His Met Val Asp Gln Tyr Asp Gln Leu Tyr Ser Lys 
            420                 425                 430         


Arg Phe Gly Val Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Arg Glu 
        435                 440                 445             


Ile Ser Leu Asn His Glu Trp Thr Phe Glu Lys Leu Arg Gln His Ile 
    450                 455                 460                 


Ser Arg Asn Ala Gln Asp Lys Gln Glu Leu His Leu Phe Met Leu Ser 
465                 470                 475                 480 


Gly Val Pro Asp Ala Val Phe Asp Leu Thr Asp Leu Asp Val Leu Lys 
                485                 490                 495     


Leu Glu Leu Ile Pro Glu Ala Lys Ile Pro Ala Lys Ile Ser Gln Met 
            500                 505                 510         


Thr Asn Leu Gln Glu Leu His Leu Cys His Cys Pro Ala Lys Val Glu 
        515                 520                 525             


Gln Thr Ala Phe Ser Phe Leu Arg Asp His Leu Arg Cys Leu His Val 
    530                 535                 540                 


Lys Phe Thr Asp Val Ala Glu Ile Pro Ala Trp Val Tyr Leu Leu Lys 
545                 550                 555                 560 


Asn Leu Arg Glu Leu Tyr Leu Ile Gly Asn Leu Asn Ser Glu Asn Asn 
                565                 570                 575     


Lys Met Ile Gly Leu Glu Ser Leu Arg Glu Leu Arg His Leu Lys Ile 
            580                 585                 590         


Leu His Val Lys Ser Asn Leu Thr Lys Val Pro Ser Asn Ile Thr Asp 
        595                 600                 605             


Val Ala Pro His Leu Thr Lys Leu Val Ile His Asn Asp Gly Thr Lys 
    610                 615                 620                 


Leu Leu Val Leu Asn Ser Leu Lys Lys Met Met Asn Val Ala Glu Leu 
625                 630                 635                 640 


Glu Leu Gln Asn Cys Glu Leu Glu Arg Ile Pro His Ala Ile Phe Ser 
                645                 650                 655     


Leu Ser Asn Leu Gln Glu Leu Asp Leu Lys Ser Asn Asn Ile Arg Thr 
            660                 665                 670         


Ile Glu Glu Ile Ile Ser Phe Gln His Leu Lys Arg Leu Thr Cys Leu 
        675                 680                 685             


Lys Leu Trp His Asn Lys Ile Val Thr Ile Pro Pro Ser Ile Thr His 
    690                 695                 700                 


Val Lys Asn Leu Glu Ser Leu Tyr Phe Ser Asn Asn Lys Leu Glu Ser 
705                 710                 715                 720 


Leu Pro Val Ala Val Phe Ser Leu Gln Lys Leu Arg Cys Leu Asp Val 
                725                 730                 735     


Ser Tyr Asn Asn Ile Ser Met Ile Pro Ile Glu Ile Gly Leu Leu Gln 
            740                 745                 750         


Asn Leu Gln His Leu His Ile Thr Gly Asn Lys Val Asp Ile Leu Pro 
        755                 760                 765             


Lys Gln Leu Phe Lys Cys Ile Lys Leu Arg Thr Leu Asn Leu Gly Gln 
    770                 775                 780                 


Asn Cys Ile Thr Ser Leu Pro Glu Lys Val Gly Gln Leu Ser Gln Leu 
785                 790                 795                 800 


Thr Gln Leu Glu Leu Lys Gly Asn Cys Leu Asp Arg Leu Pro Ala Gln 
                805                 810                 815     


Leu Gly Gln Cys Arg Met Leu Lys Lys Ser Gly Leu Val Val Glu Asp 
            820                 825                 830         


His Leu Phe Asp Thr Leu Pro Leu Glu Val Lys Glu Ala Leu Asn Gln 
        835                 840                 845             


Asp Ile Asn Ile Pro Phe Ala Asn Gly Ile 
    850                 855             


<210>  297
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Phe Thr Leu Ala Glu Val Ala Ser Leu Asn Asp Ile Gln Pro Thr 
1               5                   10                  15      


Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Met Asp Tyr Leu Ala 
            20                  25                  30          


Val Val Met Leu Met Val Ala Ile Phe Ala Gly Thr Met Gln Leu Thr 
        35                  40                  45              


Lys Asp Gln Val Val Cys Leu Pro Val Leu Pro Ser Pro Val Asn Ser 
    50                  55                  60                  


Lys Ala His Thr Pro Pro Gly Asn Ala Glu Val Thr Thr Asn Ile Pro 
65                  70                  75                  80  


Lys Met Glu Ala Ala Thr Asn Gln Asp Gln Asp Gly Arg Thr Thr Asn 
                85                  90                  95      


Asp Ile Ser Phe Gly Thr Ser Ala Val Thr Pro Asp Ile Pro Leu Arg 
            100                 105                 110         


Ala Thr Tyr Pro Arg Thr Asp Phe Ala Leu Pro Asn Gln Glu Ala Lys 
        115                 120                 125             


Lys Glu Lys Lys Asp Pro Thr Gly Arg Lys Thr Asn Leu Asp Phe Gln 
    130                 135                 140                 


Gln Tyr Val Phe Ile Asn Gln Met Cys Tyr His Leu Ala Leu Pro Trp 
145                 150                 155                 160 


Tyr Ser Lys Tyr Phe Pro Tyr Leu Ala Leu Ile His Thr Ile Ile Leu 
                165                 170                 175     


Met Val Ser Ser Asn Phe Trp Phe Lys Tyr Pro Lys Thr Cys Ser Lys 
            180                 185                 190         


Val Glu His Phe Val Ser Ile Leu Gly Lys Cys Phe Glu Ser Pro Trp 
        195                 200                 205             


Thr Thr Lys Ala Leu Ser Glu Thr Ala Cys Glu Asp Ser Glu Glu Asn 
    210                 215                 220                 


Lys Gln Arg Ile Thr Gly Ala Gln Thr Leu Pro Lys His Val Ser Thr 
225                 230                 235                 240 


Ser Ser Asp Glu Gly Ser Pro Ser Ala Ser Thr Pro Met Ile Asn Lys 
                245                 250                 255     


Thr Gly Phe Lys Phe Ser Ala Glu Lys Pro Val Ile Glu Val Pro Ser 
            260                 265                 270         


Met Thr Ile Leu Asp Lys Lys Asp Gly Glu Gln Ala Lys Ala Leu Phe 
        275                 280                 285             


Glu Lys Val Arg Lys Phe Arg Ala His Val Glu Asp Ser Asp Leu Ile 
    290                 295                 300                 


Tyr Lys Leu Tyr Val Val Gln Thr Val Ile Lys Thr Ala Lys Phe Ile 
305                 310                 315                 320 


Phe Ile Leu Cys Tyr Thr Ala Asn Phe Val Asn Ala Ile Ser Phe Glu 
                325                 330                 335     


His Val Cys Lys Pro Lys Val Glu His Leu Ile Gly Tyr Glu Val Phe 
            340                 345                 350         


Glu Cys Thr His Asn Met Ala Tyr Met Leu Lys Lys Leu Leu Ile Ser 
        355                 360                 365             


Tyr Ile Ser Ile Ile Cys Val Tyr Gly Phe Ile Cys Leu Tyr Thr Leu 
    370                 375                 380                 


Phe Trp Leu Phe Arg Ile Pro Leu Lys Glu Tyr Ser Phe Glu Lys Val 
385                 390                 395                 400 


Arg Glu Glu Ser Ser Phe Ser Asp Ile Pro Asp Val Lys Asn Asp Phe 
                405                 410                 415     


Ala Phe Leu Leu His Met Val Asp Gln Tyr Asp Gln Leu Tyr Ser Lys 
            420                 425                 430         


Arg Phe Gly Val Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Arg Glu 
        435                 440                 445             


Ile Ser Leu Asn His Glu Trp Thr Phe Glu Lys Leu Arg Gln His Ile 
    450                 455                 460                 


Ser Arg Asn Ala Gln Asp Lys Gln Glu Leu His Leu Phe Met Leu Ser 
465                 470                 475                 480 


Gly Val Pro Asp Ala Val Phe Asp Leu Thr Asp Leu Asp Val Leu Lys 
                485                 490                 495     


Leu Glu Leu Ile Pro Glu Ala Lys Ile Pro Ala Lys Ile Ser Gln Met 
            500                 505                 510         


Thr Asn Leu Gln Glu Leu His Leu Cys His Cys Pro Ala Lys Val Glu 
        515                 520                 525             


Gln Thr Ala Phe Ser Phe Leu Arg Asp His Leu Arg Cys Leu His Val 
    530                 535                 540                 


Lys Phe Thr Asp Val Ala Glu Ile Pro Ala Trp Val Tyr Leu Leu Lys 
545                 550                 555                 560 


Asn Leu Arg Glu Leu Tyr Leu Ile Gly Asn Leu Asn Ser Glu Asn Asn 
                565                 570                 575     


Lys Met Ile Gly Leu Glu Ser Leu Arg Glu Leu Arg His Leu Lys Ile 
            580                 585                 590         


Leu His Val Lys Ser Asn Leu Thr Lys Val Pro Ser Asn Ile Thr Asp 
        595                 600                 605             


Val Ala Pro His Leu Thr Lys Leu Val Ile His Asn Asp Gly Thr Lys 
    610                 615                 620                 


Leu Leu Val Leu Asn Ser Leu Lys Lys Met Met Asn Val Ala Glu Leu 
625                 630                 635                 640 


Glu Leu Gln Asn Cys Glu Leu Glu Arg Ile Pro His Ala Ile Phe Ser 
                645                 650                 655     


Leu Ser Asn Leu Gln Glu Leu Asp Leu Lys Ser Asn Asn Ile Arg Thr 
            660                 665                 670         


Ile Glu Glu Ile Ile Ser Phe Gln His Leu Lys Arg Leu Thr Cys Leu 
        675                 680                 685             


Lys Leu Trp His Asn Lys Ile Val Thr Ile Pro Pro Ser Ile Thr His 
    690                 695                 700                 


Val Lys Asn Leu Glu Ser Leu Tyr Phe Ser Asn Asn Lys Leu Glu Ser 
705                 710                 715                 720 


Leu Pro Val Ala Val Phe Ser Leu Gln Lys Leu Arg Cys Leu Asp Val 
                725                 730                 735     


Ser Tyr Asn Asn Ile Ser Met Ile Pro Ile Glu Ile Gly Leu Leu Gln 
            740                 745                 750         


Asn Leu Gln His Leu His Ile Thr Gly Asn Lys Val Asp Ile Leu Pro 
        755                 760                 765             


Lys Gln Leu Phe Lys Cys Ile Lys Leu Arg Thr Leu Asn Leu Gly Gln 
    770                 775                 780                 


Asn Cys Ile Thr Ser Leu Pro Glu Lys Val Gly Gln Leu Ser Gln Leu 
785                 790                 795                 800 


Thr Gln Leu Glu Leu Lys Gly Asn Cys Leu Asp Arg Leu Pro Ala Gln 
                805                 810                 815     


Leu Gly Gln Cys Arg Met Leu Lys Lys Ser Gly Leu Val Val Glu Asp 
            820                 825                 830         


His Leu Phe Asp Thr Leu Pro Leu Glu Val Lys Glu Ala Leu Asn Gln 
        835                 840                 845             


Asp Ile Asn Ile Pro Phe Ala Asn Gly Ile 
    850                 855             


<210>  298
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Ile Pro Val Ala Glu Phe Lys Gln Phe Thr Glu Gln Gln Pro Ala 
1               5                   10                  15      


Phe Lys Val Leu Lys Pro Trp Trp Asp Val Leu Ala Glu Tyr Leu Thr 
            20                  25                  30          


Val Ala Met Leu Met Ile Gly Val Phe Gly Cys Thr Leu Gln Val Thr 
        35                  40                  45              


Gln Asp Lys Ile Ile Cys Leu Pro Asn His Glu Leu Gln Glu Asn Leu 
    50                  55                  60                  


Ser Glu Ala Pro Cys Gln Gln Leu Leu Pro Arg Gly Ile Pro Glu Gln 
65                  70                  75                  80  


Ile Gly Ala Leu Gln Glu Val Lys Gly Leu Lys Asn Asn Leu Asp Leu 
                85                  90                  95      


Gln Gln Tyr Ser Phe Ile Asn Gln Leu Cys Tyr Glu Thr Ala Leu His 
            100                 105                 110         


Trp Tyr Ala Lys Tyr Phe Pro Tyr Leu Val Val Ile His Thr Leu Ile 
        115                 120                 125             


Phe Met Val Cys Thr Ser Phe Trp Phe Lys Phe Pro Gly Thr Ser Ser 
    130                 135                 140                 


Lys Ile Glu His Phe Ile Ser Ile Leu Gly Lys Cys Phe Asp Ser Pro 
145                 150                 155                 160 


Trp Thr Thr Arg Ala Leu Ser Glu Val Ser Gly Glu Asn Gln Lys Gly 
                165                 170                 175     


Pro Ala Ala Thr Glu Arg Ala Ala Ala Thr Ile Val Ala Met Ala Gly 
            180                 185                 190         


Thr Gly Pro Gly Lys Ala Gly Glu Gly Glu Lys Glu Lys Val Leu Ala 
        195                 200                 205             


Glu Pro Glu Lys Val Val Thr Glu Pro Pro Val Val Thr Leu Leu Asp 
    210                 215                 220                 


Lys Lys Glu Gly Glu Gln Ala Lys Ala Leu Phe Glu Lys Val Lys Lys 
225                 230                 235                 240 


Phe Arg Met His Val Glu Glu Gly Asp Ile Leu Tyr Thr Met Tyr Ile 
                245                 250                 255     


Arg Gln Thr Val Leu Lys Val Cys Lys Phe Leu Ala Ile Leu Val Tyr 
            260                 265                 270         


Asn Leu Val Tyr Val Glu Lys Ile Ser Phe Leu Val Ala Cys Arg Val 
        275                 280                 285             


Glu Thr Ser Glu Val Thr Gly Tyr Ala Ser Phe Cys Cys Asn His Thr 
    290                 295                 300                 


Lys Ala His Leu Phe Ser Lys Leu Ala Phe Cys Tyr Ile Ser Phe Val 
305                 310                 315                 320 


Cys Ile Tyr Gly Leu Thr Cys Ile Tyr Thr Leu Tyr Trp Leu Phe His 
                325                 330                 335     


Arg Pro Leu Lys Glu Tyr Ser Phe Arg Ser Val Arg Glu Glu Thr Gly 
            340                 345                 350         


Met Gly Asp Ile Pro Asp Val Lys Asn Asp Phe Ala Phe Met Leu His 
        355                 360                 365             


Leu Ile Asp Gln Tyr Asp Ser Leu Tyr Ser Lys Arg Phe Ala Val Phe 
    370                 375                 380                 


Leu Ser Glu Val Ser Glu Ser Arg Leu Lys Gln Leu Asn Leu Asn His 
385                 390                 395                 400 


Glu Trp Thr Pro Glu Lys Leu Arg Gln Lys Leu Gln Arg Asn Ala Ala 
                405                 410                 415     


Gly Arg Leu Glu Leu Ala Leu Cys Met Leu Pro Gly Leu Pro Asp Thr 
            420                 425                 430         


Val Phe Glu Leu Ser Glu Val Glu Ser Leu Arg Leu Glu Ala Ile Cys 
        435                 440                 445             


Asp Ile Thr Phe Pro Pro Gly Leu Ser Gln Leu Val His Leu Gln Glu 
    450                 455                 460                 


Leu Ser Leu Leu His Ser Pro Ala Arg Leu Pro Phe Ser Leu Gln Val 
465                 470                 475                 480 


Phe Leu Arg Asp His Leu Lys Val Met Arg Val Lys Cys Glu Glu Leu 
                485                 490                 495     


Arg Glu Val Pro Leu Trp Val Phe Gly Leu Arg Gly Leu Glu Glu Leu 
            500                 505                 510         


His Leu Glu Gly Leu Phe Pro Gln Glu Leu Ala Arg Ala Ala Thr Leu 
        515                 520                 525             


Glu Ser Leu Arg Glu Leu Lys Gln Leu Lys Val Leu Ser Leu Arg Ser 
    530                 535                 540                 


Asn Ala Gly Lys Val Pro Ala Ser Val Thr Asp Val Ala Gly His Leu 
545                 550                 555                 560 


Gln Arg Leu Ser Leu His Asn Asp Gly Ala Arg Leu Val Ala Leu Asn 
                565                 570                 575     


Ser Leu Lys Lys Leu Ala Ala Leu Arg Glu Leu Glu Leu Val Ala Cys 
            580                 585                 590         


Gly Leu Glu Arg Ile Pro His Ala Val Phe Ser Leu Gly Ala Leu Gln 
        595                 600                 605             


Glu Leu Asp Leu Lys Asp Asn His Leu Arg Ser Ile Glu Glu Ile Leu 
    610                 615                 620                 


Ser Phe Gln His Cys Arg Lys Leu Val Thr Leu Arg Leu Trp His Asn 
625                 630                 635                 640 


Gln Ile Ala Tyr Val Pro Glu His Val Arg Lys Leu Arg Ser Leu Glu 
                645                 650                 655     


Gln Leu Tyr Leu Ser Tyr Asn Lys Leu Glu Thr Leu Pro Ser Gln Leu 
            660                 665                 670         


Gly Leu Cys Ser Gly Leu Arg Leu Leu Asp Val Ser His Asn Gly Leu 
        675                 680                 685             


His Ser Leu Pro Pro Glu Val Gly Leu Leu Gln Asn Leu Gln His Leu 
    690                 695                 700                 


Ala Leu Ser Tyr Asn Ala Leu Glu Ala Leu Pro Glu Glu Leu Phe Phe 
705                 710                 715                 720 


Cys Arg Lys Leu Arg Thr Leu Leu Leu Gly Asp Asn Gln Leu Ser Gln 
                725                 730                 735     


Leu Ser Pro His Val Gly Ala Leu Arg Ala Leu Ser Arg Leu Glu Leu 
            740                 745                 750         


Lys Gly Asn Arg Leu Glu Ala Leu Pro Glu Glu Leu Gly Asn Cys Gly 
        755                 760                 765             


Gly Leu Lys Lys Ala Gly Leu Leu Val Glu Asp Thr Leu Tyr Gln Gly 
    770                 775                 780                 


Leu Pro Ala Glu Val Arg Asp Lys Met Glu Glu Glu 
785                 790                 795     


<210>  299
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Val Cys Thr Ser Phe Trp Phe Lys Phe Pro Gly Thr Ser Ser Lys 
1               5                   10                  15      


Ile Glu His Phe Ile Ser Ile Leu Gly Lys Cys Phe Asp Ser Pro Trp 
            20                  25                  30          


Thr Thr Arg Ala Leu Ser Glu Val Ser Gly Glu Asn Gln Lys Gly Pro 
        35                  40                  45              


Ala Ala Thr Glu Arg Ala Ala Ala Thr Ile Val Ala Met Ala Gly Thr 
    50                  55                  60                  


Gly Pro Gly Lys Ala Gly Glu Gly Glu Lys Glu Lys Val Leu Ala Glu 
65                  70                  75                  80  


Pro Glu Lys Val Val Thr Glu Pro Pro Val Val Thr Leu Leu Asp Lys 
                85                  90                  95      


Lys Glu Gly Glu Gln Ala Lys Ala Leu Phe Glu Lys Val Lys Lys Phe 
            100                 105                 110         


Arg Met His Val Glu Glu Gly Asp Ile Leu Tyr Thr Met Tyr Ile Arg 
        115                 120                 125             


Gln Thr Val Leu Lys Val Cys Lys Phe Leu Ala Ile Leu Val Tyr Asn 
    130                 135                 140                 


Leu Val Tyr Val Glu Lys Ile Ser Phe Leu Val Ala Cys Arg Val Glu 
145                 150                 155                 160 


Thr Ser Glu Val Thr Gly Tyr Ala Ser Phe Cys Cys Asn His Thr Lys 
                165                 170                 175     


Ala His Leu Phe Ser Lys Leu Ala Phe Cys Tyr Ile Ser Phe Val Cys 
            180                 185                 190         


Ile Tyr Gly Leu Thr Cys Ile Tyr Thr Leu Tyr Trp Leu Phe His Arg 
        195                 200                 205             


Pro Leu Lys Glu Tyr Ser Phe Arg Ser Val Arg Glu Glu Thr Gly Met 
    210                 215                 220                 


Gly Asp Ile Pro Asp Val Lys Asn Asp Phe Ala Phe Met Leu His Leu 
225                 230                 235                 240 


Ile Asp Gln Tyr Asp Ser Leu Tyr Ser Lys Arg Phe Ala Val Phe Leu 
                245                 250                 255     


Ser Glu Val Ser Glu Ser Arg Leu Lys Gln Leu Asn Leu Asn His Glu 
            260                 265                 270         


Trp Thr Pro Glu Lys Leu Arg Gln Lys Leu Gln Arg Asn Ala Ala Gly 
        275                 280                 285             


Arg Leu Glu Leu Ala Leu Cys Met Leu Pro Gly Leu Pro Asp Thr Val 
    290                 295                 300                 


Phe Glu Leu Ser Glu Val Glu Ser Leu Arg Leu Glu Ala Ile Cys Asp 
305                 310                 315                 320 


Ile Thr Phe Pro Pro Gly Leu Ser Gln Leu Val His Leu Gln Glu Leu 
                325                 330                 335     


Ser Leu Leu His Ser Pro Ala Arg Leu Pro Phe Ser Leu Gln Val Phe 
            340                 345                 350         


Leu Arg Asp His Leu Lys Val Met Arg Val Lys Cys Glu Glu Leu Arg 
        355                 360                 365             


Glu Val Pro Leu Trp Val Phe Gly Leu Arg Gly Leu Glu Glu Leu His 
    370                 375                 380                 


Leu Glu Gly Leu Phe Pro Gln Glu Leu Ala Arg Ala Ala Thr Leu Glu 
385                 390                 395                 400 


Ser Leu Arg Glu Leu Lys Gln Leu Lys Val Leu Ser Leu Arg Ser Asn 
                405                 410                 415     


Ala Gly Lys Val Pro Ala Ser Val Thr Asp Val Ala Gly His Leu Gln 
            420                 425                 430         


Arg Leu Ser Leu His Asn Asp Gly Ala Arg Leu Val Ala Leu Asn Ser 
        435                 440                 445             


Leu Lys Lys Leu Ala Ala Leu Arg Glu Leu Glu Leu Val Ala Cys Gly 
    450                 455                 460                 


Leu Glu Arg Ile Pro His Ala Val Phe Ser Leu Gly Ala Leu Gln Glu 
465                 470                 475                 480 


Leu Asp Leu Lys Asp Asn His Leu Arg Ser Ile Glu Glu Ile Leu Ser 
                485                 490                 495     


Phe Gln His Cys Arg Lys Leu Val Thr Leu Arg Leu Trp His Asn Gln 
            500                 505                 510         


Ile Ala Tyr Val Pro Glu His Val Arg Lys Leu Arg Ser Leu Glu Gln 
        515                 520                 525             


Leu Tyr Leu Ser Tyr Asn Lys Leu Glu Thr Leu Pro Ser Gln Leu Gly 
    530                 535                 540                 


Leu Cys Ser Gly Leu Arg Leu Leu Asp Val Ser His Asn Gly Leu His 
545                 550                 555                 560 


Ser Leu Pro Pro Glu Val Gly Leu Leu Gln Asn Leu Gln His Leu Ala 
                565                 570                 575     


Leu Ser Tyr Asn Ala Leu Glu Ala Leu Pro Glu Glu Leu Phe Phe Cys 
            580                 585                 590         


Arg Lys Leu Arg Thr Leu Leu Leu Gly Asp Asn Gln Leu Ser Gln Leu 
        595                 600                 605             


Ser Pro His Val Gly Ala Leu Arg Ala Leu Ser Arg Leu Glu Leu Lys 
    610                 615                 620                 


Gly Asn Arg Leu Glu Ala Leu Pro Glu Glu Leu Gly Asn Cys Gly Gly 
625                 630                 635                 640 


Leu Lys Lys Ala Gly Leu Leu Val Glu Asp Thr Leu Tyr Gln Gly Leu 
                645                 650                 655     


Pro Ala Glu Val Arg Asp Lys Met Glu Glu Glu 
            660                 665         


<210>  300
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Ile Pro Val Ala Glu Phe Lys Gln Phe Thr Glu Gln Gln Pro Ala 
1               5                   10                  15      


Phe Lys Val Leu Lys Pro Trp Trp Asp Val Leu Ala Glu Tyr Leu Thr 
            20                  25                  30          


Val Ala Met Leu Met Ile Gly Val Phe Gly Cys Thr Leu Gln Val Thr 
        35                  40                  45              


Gln Asp Lys Ile Ile Cys Leu Pro Asn His Glu Leu Gln Glu Asn Leu 
    50                  55                  60                  


Ser Glu Ala Pro Cys Gln Gln Leu Leu Pro Arg Gly Ile Pro Glu Gln 
65                  70                  75                  80  


Ile Gly Ala Leu Gln Glu Val Lys Gly Leu Lys Asn Asn Leu Asp Leu 
                85                  90                  95      


Gln Gln Tyr Ser Phe Ile Asn Gln Leu Cys Tyr Glu Thr Ala Leu His 
            100                 105                 110         


Trp Tyr Ala Lys Tyr Phe Pro Tyr Leu Val Val Ile His Thr Leu Ile 
        115                 120                 125             


Phe Met Val Cys Thr Ser Phe Trp Phe Lys Phe Pro Gly Thr Ser Ser 
    130                 135                 140                 


Lys Ile Glu His Phe Ile Ser Ile Leu Gly Lys Cys Phe Asp Ser Pro 
145                 150                 155                 160 


Trp Thr Thr Arg Ala Leu Ser Glu Val Ser Gly Glu Asn Gln Lys Gly 
                165                 170                 175     


Pro Ala Ala Thr Glu Arg Ala Ala Ala Thr Ile Val Ala Met Ala Gly 
            180                 185                 190         


Thr Gly Pro Gly Lys Ala Gly Glu Gly Glu Lys Glu Lys Val Leu Ala 
        195                 200                 205             


Glu Pro Glu Lys Val Val Thr Glu Pro Pro Val Val Thr Leu Leu Asp 
    210                 215                 220                 


Lys Lys Glu Gly Glu Gln Ala Lys Ala Leu Phe Glu Lys Val Lys Lys 
225                 230                 235                 240 


Phe Arg Met His Val Glu Glu Gly Asp Ile Leu Tyr Thr Met Tyr Ile 
                245                 250                 255     


Arg Gln Thr Val Leu Lys Val Cys Lys Phe Leu Ala Ile Leu Val Tyr 
            260                 265                 270         


Asn Leu Val Tyr Val Glu Lys Ile Ser Phe Leu Val Ala Cys Arg Val 
        275                 280                 285             


Glu Thr Ser Glu Val Thr Gly Tyr Ala Ser Phe Cys Cys Asn His Thr 
    290                 295                 300                 


Lys Ala His Leu Phe Ser Lys Leu Ala Phe Cys Tyr Ile Ser Phe Val 
305                 310                 315                 320 


Cys Ile Tyr Gly Leu Thr Cys Ile Tyr Thr Leu Tyr Trp Leu Phe His 
                325                 330                 335     


Arg Pro Leu Lys Glu Tyr Ser Phe Arg Ser Val Arg Glu Glu Thr Gly 
            340                 345                 350         


Met Gly Asp Ile Pro Asp Val Lys Asn Asp Phe Ala Phe Met Leu His 
        355                 360                 365             


Leu Ile Asp Gln Tyr Asp Ser Leu Tyr Ser Lys Arg Phe Ala Val Phe 
    370                 375                 380                 


Leu Ser Glu Val Ser Glu Ser Arg Leu Lys Gln Leu Asn Leu Asn His 
385                 390                 395                 400 


Glu Trp Thr Pro Glu Lys Leu Arg Gln Lys Leu Gln Arg Asn Ala Ala 
                405                 410                 415     


Gly Arg Leu Glu Leu Ala Leu Cys Met Leu Pro Gly Leu Pro Asp Thr 
            420                 425                 430         


Val Phe Glu Leu Ser Glu Val Glu Ser Leu Arg Leu Glu Ala Ile Cys 
        435                 440                 445             


Asp Ile Thr Phe Pro Pro Gly Leu Ser Gln Leu Val His Leu Gln Glu 
    450                 455                 460                 


Leu Ser Leu Leu His Ser Pro Ala Arg Leu Pro Phe Ser Leu Gln Val 
465                 470                 475                 480 


Phe Leu Arg Asp His Leu Lys Val Met Arg Val Lys Cys Glu Glu Leu 
                485                 490                 495     


Arg Glu Val Pro Leu Trp Val Phe Gly Leu Arg Gly Leu Glu Glu Leu 
            500                 505                 510         


His Leu Glu Gly Leu Phe Pro Gln Glu Leu Ala Arg Ala Ala Thr Leu 
        515                 520                 525             


Glu Ser Leu Arg Glu Leu Lys Gln Leu Lys Val Leu Ser Leu Arg Ser 
    530                 535                 540                 


Asn Ala Gly Lys Val Pro Ala Ser Val Thr Asp Val Ala Gly His Leu 
545                 550                 555                 560 


Gln Arg Leu Ser Leu His Asn Asp Gly Ala Arg Leu Val Ala Leu Asn 
                565                 570                 575     


Ser Leu Lys Lys Leu Ala Ala Leu Arg Glu Leu Glu Leu Val Ala Cys 
            580                 585                 590         


Gly Leu Glu Arg Ile Pro His Ala Val Phe Ser Leu Gly Ala Leu Gln 
        595                 600                 605             


Glu Leu Asp Leu Lys Asp Asn His Leu Arg Ser Ile Glu Glu Ile Leu 
    610                 615                 620                 


Ser Phe Gln His Cys Arg Lys Leu Val Thr Leu Arg Leu Trp His Asn 
625                 630                 635                 640 


Gln Ile Ala Tyr Val Pro Glu His Val Arg Lys Leu Arg Ser Leu Glu 
                645                 650                 655     


Gln Leu Tyr Leu Ser Tyr Asn Lys Leu Glu Thr Leu Pro Ser Gln Leu 
            660                 665                 670         


Gly Leu Cys Ser Gly Leu Arg Leu Leu Asp Val Ser His Asn Gly Leu 
        675                 680                 685             


His Ser Leu Pro Pro Glu Val Gly Leu Leu Gln Asn Leu Gln His Leu 
    690                 695                 700                 


Ala Leu Ser Tyr Asn Ala Leu Glu Ala Leu Pro Glu Glu Leu Phe Phe 
705                 710                 715                 720 


Cys Arg Lys Leu Arg Thr Leu Leu Leu Gly Asp Asn Gln Leu Ser Gln 
                725                 730                 735     


Leu Ser Pro His Val Gly Ala Leu Arg Ala Leu Ser Arg Leu Glu Leu 
            740                 745                 750         


Lys Gly Asn Arg Leu Glu Ala Leu Pro Glu Glu Leu Gly Asn Cys Gly 
        755                 760                 765             


Gly Leu Lys Lys Ala Gly Leu Leu Val Glu Asp Thr Leu Tyr Gln Gly 
    770                 775                 780                 


Leu Pro Ala Glu Val Arg Asp Lys Met Glu Glu Glu 
785                 790                 795     


<210>  301
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Asp Phe Leu Leu Leu Gly Leu Cys Leu Tyr Trp Leu Leu Arg Arg 
1               5                   10                  15      


Pro Ser Gly Val Val Leu Cys Leu Leu Gly Ala Cys Phe Gln Met Leu 
            20                  25                  30          


Pro Ala Ala Pro Ser Gly Cys Pro Gln Leu Cys Arg Cys Glu Gly Arg 
        35                  40                  45              


Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr Glu Ala Pro His Asn Leu 
    50                  55                  60                  


Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr Asn Ser Leu Ser Glu Leu 
65                  70                  75                  80  


Arg Ala Gly Gln Phe Thr Gly Leu Met Gln Leu Thr Trp Leu Tyr Leu 
                85                  90                  95      


Asp His Asn His Ile Cys Ser Val Gln Gly Asp Ala Phe Gln Lys Leu 
            100                 105                 110         


Arg Arg Val Lys Glu Leu Thr Leu Ser Ser Asn Gln Ile Thr Gln Leu 
        115                 120                 125             


Pro Asn Thr Thr Phe Arg Pro Met Pro Asn Leu Arg Ser Val Asp Leu 
    130                 135                 140                 


Ser Tyr Asn Lys Leu Gln Ala Leu Ala Pro Asp Leu Phe His Gly Leu 
145                 150                 155                 160 


Arg Lys Leu Thr Thr Leu His Met Arg Ala Asn Ala Ile Gln Phe Val 
                165                 170                 175     


Pro Val Arg Ile Phe Gln Asp Cys Arg Ser Leu Lys Phe Leu Asp Ile 
            180                 185                 190         


Gly Tyr Asn Gln Leu Lys Ser Leu Ala Arg Asn Ser Phe Ala Gly Leu 
        195                 200                 205             


Phe Lys Leu Thr Glu Leu His Leu Glu His Asn Asp Leu Val Lys Val 
    210                 215                 220                 


Asn Phe Ala His Phe Pro Arg Leu Ile Ser Leu His Ser Leu Cys Leu 
225                 230                 235                 240 


Arg Arg Asn Lys Val Ala Ile Val Val Ser Ser Leu Asp Trp Val Trp 
                245                 250                 255     


Asn Leu Glu Lys Met Asp Leu Ser Gly Asn Glu Ile Glu Tyr Met Glu 
            260                 265                 270         


Pro His Val Phe Glu Thr Val Pro His Leu Gln Ser Leu Gln Leu Asp 
        275                 280                 285             


Ser Asn Arg Leu Thr Tyr Ile Glu Pro Arg Ile Leu Asn Ser Trp Lys 
    290                 295                 300                 


Ser Leu Thr Ser Ile Thr Leu Ala Gly Asn Leu Trp Asp Cys Gly Arg 
305                 310                 315                 320 


Asn Val Cys Ala Leu Ala Ser Trp Leu Asn Asn Phe Gln Gly Arg Tyr 
                325                 330                 335     


Asp Gly Asn Leu Gln Cys Ala Ser Pro Glu Tyr Ala Gln Gly Glu Asp 
            340                 345                 350         


Val Leu Asp Ala Val Tyr Ala Phe His Leu Cys Glu Asp Gly Ala Glu 
        355                 360                 365             


Pro Thr Ser Gly His Leu Leu Ser Ala Val Thr Asn Arg Ser Asp Leu 
    370                 375                 380                 


Gly Pro Pro Ala Ser Ser Ala Thr Thr Leu Ala Asp Gly Gly Glu Gly 
385                 390                 395                 400 


Gln His Asp Gly Thr Phe Glu Pro Ala Thr Val Ala Leu Pro Gly Gly 
                405                 410                 415     


Glu His Ala Glu Asn Ala Val Gln Ile His Lys Val Val Thr Gly Thr 
            420                 425                 430         


Met Ala Leu Ile Phe Ser Phe Leu Ile Val Val Leu Val Leu Tyr Val 
        435                 440                 445             


Ser Trp Lys Cys Phe Pro Ala Ser Leu Arg Gln Leu Arg Gln Cys Phe 
    450                 455                 460                 


Val Thr Gln Arg Arg Lys Gln Lys Gln Lys Gln Thr Met His Gln Met 
465                 470                 475                 480 


Ala Ala Met Ser Ala Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Asn His 
                485                 490                 495     


Ile Glu Gly Ala Leu Val Ile Ile Asn Glu Tyr Gly Ser Cys Thr Cys 
            500                 505                 510         


His Gln Gln Pro Ala Arg Glu Cys Glu Val 
        515                 520         


<210>  302
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
    50                  55                  60                  


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
65                  70                  75                  80  


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
                85                  90                  95      


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
            100                 105                 110         


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
        115                 120                 125             


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
    130                 135                 140                 


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
145                 150                 155                 160 


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
                165                 170                 175     


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
            180                 185                 190         


Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 
        195                 200                 205             


Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 
    210                 215                 220                 


Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Asp 
225                 230                 235                 240 


Trp Leu Phe Val Val Val Val Cys Leu Ala Ala Phe Leu Ile Phe Leu 
                245                 250                 255     


Leu Leu Gly Ile Cys Trp Cys Gln Cys Cys Pro His Thr Cys Cys Cys 
            260                 265                 270         


Tyr Val Arg Cys Pro Cys Cys Pro Asp Lys Cys Cys Cys Pro Glu Ala 
        275                 280                 285             


Leu Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro Ser Ile Tyr 
    290                 295                 300                 


Ala Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr Pro Pro Pro 
305                 310                 315                 320 


Pro Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr Pro Gly Gly 
                325                 330                 335     


Tyr Pro Gly Asp Val Asp Arg Ser Ser Ser Ala Gly Gly Gln Gly Ser 
            340                 345                 350         


Tyr Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala Ser Val Arg 
        355                 360                 365             


Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp Ser Met Arg Val 
    370                 375                 380                 


Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp Pro Ser Arg Pro 
385                 390                 395                 400 


Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser Glu Val Thr Ser 
                405                 410                 415     


Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser Pro Arg Ser Pro 
        435                 440                 445             


Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala Gly Gly Gly Trp 
    450                 455                 460                 


Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala Leu Asp Asp Leu 
465                 470                 475                 480 


Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser Pro Thr Ser Asn 
                485                 490                 495     


Gly Gly Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser Arg Ser Arg Asp 
            500                 505                 510         


Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro Arg Ser Arg Asp 
        515                 520                 525             


Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro Pro Ala Asp Pro 
    530                 535                 540                 


Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp Asn Gly Ser Arg 
545                 550                 555                 560 


Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu Glu Ala Val Arg 
                565                 570                 575     


Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys Glu Glu Glu Glu 
            580                 585                 590         


Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser Glu Thr Asp Ser 
        595                 600                 605             


Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu Ala Leu Ser Arg 
    610                 615                 620                 


Glu Ser Leu Val Val 
625                 


<210>  303
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
    50                  55                  60                  


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
65                  70                  75                  80  


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
                85                  90                  95      


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
            100                 105                 110         


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
        115                 120                 125             


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
    130                 135                 140                 


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
145                 150                 155                 160 


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
                165                 170                 175     


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
            180                 185                 190         


Arg Arg Ile Thr Ile Thr Gly Met Tyr Ala Ala Gly Lys Ala Ala Thr 
        195                 200                 205             


Ser Gly Val Pro Ser Ile Tyr Ala Pro Ser Thr Tyr Ala His Leu Ser 
    210                 215                 220                 


Pro Ala Lys Thr Pro Pro Pro Pro Ala Met Ile Pro Met Gly Pro Ala 
225                 230                 235                 240 


Tyr Asn Gly Tyr Pro Gly Gly Tyr Pro Gly Asp Val Asp Arg Ser Ser 
                245                 250                 255     


Ser Ala Gly Gly Gln Gly Ser Tyr Val Pro Leu Leu Arg Asp Thr Asp 
            260                 265                 270         


Ser Ser Val Ala Ser Glu Val Arg Ser Gly Tyr Arg Ile Gln Ala Ser 
        275                 280                 285             


Gln Gln Asp Asp Ser Met Arg Val Leu Tyr Tyr Met Glu Lys Glu Leu 
    290                 295                 300                 


Ala Asn Phe Asp Pro Ser Arg Pro Gly Pro Pro Ser Gly Arg Val Glu 
305                 310                 315                 320 


Arg Ala Met Ser Glu Val Thr Ser Leu His Glu Asp Asp Trp Arg Ser 
                325                 330                 335     


Arg Pro Ser Arg Gly Pro Ala Leu Thr Pro Ile Arg Asp Glu Glu Trp 
            340                 345                 350         


Gly Gly His Ser Pro Arg Ser Pro Arg Gly Trp Asp Gln Glu Pro Ala 
        355                 360                 365             


Arg Glu Gln Ala Gly Gly Gly Trp Arg Ala Arg Arg Pro Arg Ala Arg 
    370                 375                 380                 


Ser Val Asp Ala Leu Asp Asp Leu Thr Pro Pro Ser Thr Ala Glu Ser 
385                 390                 395                 400 


Gly Ser Arg Ser Pro Thr Ser Asn Gly Gly Arg Ser Arg Ala Tyr Met 
                405                 410                 415     


Pro Pro Arg Ser Arg Ser Arg Asp Asp Leu Tyr Asp Gln Asp Asp Ser 
            420                 425                 430         


Arg Asp Phe Pro Arg Ser Arg Asp Pro His Tyr Asp Asp Phe Arg Ser 
        435                 440                 445             


Arg Glu Arg Pro Pro Ala Asp Pro Arg Ser His His His Arg Thr Arg 
    450                 455                 460                 


Asp Pro Arg Asp Asn Gly Ser Arg Ser Gly Asp Leu Pro Tyr Asp Gly 
465                 470                 475                 480 


Arg Leu Leu Glu Glu Ala Val Arg Lys Lys Gly Ser Glu Glu Arg Arg 
                485                 490                 495     


Arg Pro His Lys Glu Glu Glu Glu Glu Ala Tyr Tyr Pro Pro Ala Pro 
            500                 505                 510         


Pro Pro Tyr Ser Glu Thr Asp Ser Gln Ala Ser Arg Glu Arg Arg Leu 
        515                 520                 525             


Lys Lys Asn Leu Ala Leu Ser Arg Glu Ser Leu Val Val 
    530                 535                 540     


<210>  304
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
    50                  55                  60                  


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
65                  70                  75                  80  


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
                85                  90                  95      


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
            100                 105                 110         


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
        115                 120                 125             


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
    130                 135                 140                 


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
145                 150                 155                 160 


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
                165                 170                 175     


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
            180                 185                 190         


Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 
        195                 200                 205             


Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 
    210                 215                 220                 


Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Asp 
225                 230                 235                 240 


Trp Leu Phe Val Val Val Val Cys Leu Ala Ala Phe Leu Ile Phe Leu 
                245                 250                 255     


Leu Leu Gly Ile Cys Trp Cys Gln Cys Cys Pro His Thr Cys Cys Cys 
            260                 265                 270         


Tyr Val Arg Cys Pro Cys Cys Pro Asp Lys Cys Cys Cys Pro Glu Ala 
        275                 280                 285             


Leu Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro Ser Ile Tyr 
    290                 295                 300                 


Ala Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr Pro Pro Pro 
305                 310                 315                 320 


Pro Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr Pro Gly Gly 
                325                 330                 335     


Tyr Pro Gly Asp Val Asp Arg Ser Ser Ser Ala Gly Gly Gln Gly Ser 
            340                 345                 350         


Tyr Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala Ser Glu Val 
        355                 360                 365             


Arg Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp Ser Met Arg 
    370                 375                 380                 


Val Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp Pro Ser Arg 
385                 390                 395                 400 


Pro Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser Glu Val Thr 
                405                 410                 415     


Ser Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg Gly Pro Ala 
            420                 425                 430         


Leu Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser Pro Arg Ser 
        435                 440                 445             


Pro Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala Gly Gly Gly 
    450                 455                 460                 


Trp Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala Leu Asp Asp 
465                 470                 475                 480 


Leu Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser Pro Thr Ser 
                485                 490                 495     


Asn Gly Gly Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser Arg Ser Arg 
            500                 505                 510         


Asp Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro Arg Ser Arg 
        515                 520                 525             


Asp Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro Pro Ala Asp 
    530                 535                 540                 


Pro Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp Asn Gly Ser 
545                 550                 555                 560 


Arg Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu Glu Ala Val 
                565                 570                 575     


Arg Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys Glu Glu Glu 
            580                 585                 590         


Glu Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser Glu Thr Asp 
        595                 600                 605             


Ser Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu Ala Leu Ser 
    610                 615                 620                 


Arg Glu Ser Leu Val Val 
625                 630 


<210>  305
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
    50                  55                  60                  


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
65                  70                  75                  80  


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
                85                  90                  95      


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
            100                 105                 110         


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
        115                 120                 125             


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
    130                 135                 140                 


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
145                 150                 155                 160 


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
                165                 170                 175     


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
            180                 185                 190         


Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 
        195                 200                 205             


Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 
    210                 215                 220                 


Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Gly 
225                 230                 235                 240 


Arg Thr Ser Gly Val Ala Glu Leu Leu Pro Gly Phe Gln Ala Gly Pro 
                245                 250                 255     


Ile Glu Asp Trp Leu Phe Val Val Val Val Cys Leu Ala Ala Phe Leu 
            260                 265                 270         


Ile Phe Leu Leu Leu Gly Ile Cys Trp Cys Gln Cys Cys Pro His Thr 
        275                 280                 285             


Cys Cys Cys Tyr Val Arg Cys Pro Cys Cys Pro Asp Lys Cys Cys Cys 
    290                 295                 300                 


Pro Glu Ala Leu Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro 
305                 310                 315                 320 


Ser Ile Tyr Ala Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr 
                325                 330                 335     


Pro Pro Pro Pro Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr 
            340                 345                 350         


Pro Gly Gly Tyr Pro Gly Asp Val Asp Arg Ser Ser Ser Ala Gly Gly 
        355                 360                 365             


Gln Gly Ser Tyr Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala 
    370                 375                 380                 


Ser Glu Val Arg Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp 
385                 390                 395                 400 


Ser Met Arg Val Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp 
                405                 410                 415     


Pro Ser Arg Pro Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser 
            420                 425                 430         


Glu Val Thr Ser Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg 
        435                 440                 445             


Gly Pro Ala Leu Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser 
    450                 455                 460                 


Pro Arg Ser Pro Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala 
465                 470                 475                 480 


Gly Gly Gly Trp Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala 
                485                 490                 495     


Leu Asp Asp Leu Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser 
            500                 505                 510         


Pro Thr Ser Asn Gly Gly Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser 
        515                 520                 525             


Arg Ser Arg Asp Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro 
    530                 535                 540                 


Arg Ser Arg Asp Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro 
545                 550                 555                 560 


Pro Ala Asp Pro Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp 
                565                 570                 575     


Asn Gly Ser Arg Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu 
            580                 585                 590         


Glu Ala Val Arg Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys 
        595                 600                 605             


Glu Glu Glu Glu Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser 
    610                 615                 620                 


Glu Thr Asp Ser Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu 
625                 630                 635                 640 


Ala Leu Ser Arg Glu Ser Leu Val Val 
                645                 


<210>  306
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
    50                  55                  60                  


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
65                  70                  75                  80  


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
                85                  90                  95      


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
            100                 105                 110         


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
        115                 120                 125             


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
    130                 135                 140                 


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
145                 150                 155                 160 


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
                165                 170                 175     


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
            180                 185                 190         


Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 
        195                 200                 205             


Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 
    210                 215                 220                 


Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Val 
225                 230                 235                 240 


Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro Ser Ile Tyr Ala 
                245                 250                 255     


Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr Pro Pro Pro Pro 
            260                 265                 270         


Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr Pro Gly Gly Tyr 
        275                 280                 285             


Pro Gly Asp Val Asp Arg Ser Ser Ser Ala Gly Gly Gln Gly Ser Tyr 
    290                 295                 300                 


Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala Ser Glu Val Arg 
305                 310                 315                 320 


Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp Ser Met Arg Val 
                325                 330                 335     


Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp Pro Ser Arg Pro 
            340                 345                 350         


Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser Glu Val Thr Ser 
        355                 360                 365             


Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg Gly Pro Ala Leu 
    370                 375                 380                 


Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser Pro Arg Ser Pro 
385                 390                 395                 400 


Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala Gly Gly Gly Trp 
                405                 410                 415     


Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala Leu Asp Asp Leu 
            420                 425                 430         


Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser Pro Thr Ser Asn 
        435                 440                 445             


Gly Gly Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser Arg Ser Arg Asp 
    450                 455                 460                 


Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro Arg Ser Arg Asp 
465                 470                 475                 480 


Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro Pro Ala Asp Pro 
                485                 490                 495     


Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp Asn Gly Ser Arg 
            500                 505                 510         


Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu Glu Ala Val Arg 
        515                 520                 525             


Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys Glu Glu Glu Glu 
    530                 535                 540                 


Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser Glu Thr Asp Ser 
545                 550                 555                 560 


Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu Ala Leu Ser Arg 
                565                 570                 575     


Glu Ser Leu Val Val 
            580     


<210>  307
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Ser Leu Glu Gln Arg Ser Leu His Cys Lys Pro Glu Glu Ala Leu 
1               5                   10                  15      


Glu Ala Gln Gln Glu Ala Leu Gly Leu Val Cys Val Gln Ala Ala Thr 
            20                  25                  30          


Ser Ser Ser Ser Pro Leu Val Leu Gly Thr Leu Glu Glu Val Pro Thr 
        35                  40                  45              


Ala Gly Ser Thr Asp Pro Pro Gln Ser Pro Gln Gly Ala Ser Ala Phe 
    50                  55                  60                  


Pro Thr Thr Ile Asn Phe Thr Arg Gln Arg Gln Pro Ser Glu Gly Ser 
65                  70                  75                  80  


Ser Ser Arg Glu Glu Glu Gly Pro Ser Thr Ser Cys Ile Leu Glu Ser 
                85                  90                  95      


Leu Phe Arg Ala Val Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 
            100                 105                 110         


Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu Met 
        115                 120                 125             


Leu Glu Ser Val Ile Lys Asn Tyr Lys His Cys Phe Pro Glu Ile Phe 
    130                 135                 140                 


Gly Lys Ala Ser Glu Ser Leu Gln Leu Val Phe Gly Ile Asp Val Lys 
145                 150                 155                 160 


Glu Ala Asp Pro Thr Gly His Ser Tyr Val Leu Val Thr Cys Leu Gly 
                165                 170                 175     


Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn Gln Ile Met Pro Lys Thr 
            180                 185                 190         


Gly Phe Leu Ile Ile Val Leu Val Met Ile Ala Met Glu Gly Gly His 
        195                 200                 205             


Ala Pro Glu Glu Glu Ile Trp Glu Glu Leu Ser Val Met Glu Val Tyr 
    210                 215                 220                 


Asp Gly Arg Glu His Ser Ala Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
225                 230                 235                 240 


Gln Asp Leu Val Gln Glu Lys Tyr Leu Glu Tyr Arg Gln Val Pro Asp 
                245                 250                 255     


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala 
            260                 265                 270         


Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr Val Ile Lys Val Ser Ala 
        275                 280                 285             


Arg Val Arg Phe Phe Phe Pro Ser Leu Arg Glu Ala Ala Leu Arg Glu 
    290                 295                 300                 


Glu Glu Glu Gly Val 
305                 


<210>  308
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Arg Lys Gly Lys Gly Pro Ile Cys Leu Phe Ser Arg Pro Thr Leu 
1               5                   10                  15      


Arg Pro Ser Arg Ser Lys Val Ser Leu Ile Glu Gly Arg Gly Ala Asn 
            20                  25                  30          


Met Ala Ala Arg Trp Arg Phe Trp Cys Val Ser Val Thr Met Val Val 
        35                  40                  45              


Ala Leu Leu Ile Val Cys Asp Val Pro Ser Ala Ser Ala Gln Arg Lys 
    50                  55                  60                  


Lys Glu Met Val Leu Ser Glu Lys Val Ser Gln Leu Met Glu Trp Thr 
65                  70                  75                  80  


Asn Lys Arg Pro Val Ile Arg Met Asn Gly Asp Lys Phe Arg Arg Leu 
                85                  90                  95      


Val Lys Ala Pro Pro Arg Asn Tyr Ser Val Ile Val Met Phe Thr Ala 
            100                 105                 110         


Leu Gln Leu His Arg Gln Cys Val Val Cys Lys Gln Ala Asp Glu Glu 
        115                 120                 125             


Phe Gln Ile Leu Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Thr Asn 
    130                 135                 140                 


Arg Ile Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val Phe 
145                 150                 155                 160 


Gln Met Leu Asn Met Asn Ser Ala Pro Thr Phe Ile Asn Phe Pro Ala 
                165                 170                 175     


Lys Gly Lys Pro Lys Arg Gly Asp Thr Tyr Glu Leu Gln Val Arg Gly 
            180                 185                 190         


Phe Ser Ala Glu Gln Ile Ala Arg Trp Ile Ala Asp Arg Thr Asp Val 
        195                 200                 205             


Asn Ile Arg Val Ile Arg Pro Pro Asn Tyr Ala Gly Pro Leu Met Leu 
    210                 215                 220                 


Gly Leu Leu Leu Ala Val Ile Gly Gly Leu Val Tyr Leu Arg Arg Ser 
225                 230                 235                 240 


Asn Met Glu Phe Leu Phe Asn Lys Thr Gly Trp Ala Phe Ala Ala Leu 
                245                 250                 255     


Cys Phe Val Leu Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg 
            260                 265                 270         


Gly Pro Pro Tyr Ala His Lys Asn Pro His Thr Gly His Val Asn Tyr 
        275                 280                 285             


Ile His Gly Ser Ser Gln Ala Gln Phe Val Ala Glu Thr His Ile Val 
    290                 295                 300                 


Leu Leu Phe Asn Gly Gly Val Thr Leu Gly Met Val Leu Leu Cys Glu 
305                 310                 315                 320 


Ala Ala Thr Ser Asp Met Asp Ile Gly Lys Arg Lys Ile Met Cys Val 
                325                 330                 335     


Ala Gly Ile Gly Leu Val Val Leu Phe Phe Ser Trp Met Leu Ser Ile 
            340                 345                 350         


Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr Ser Phe Leu Met Ser 
        355                 360                 365         


<210>  309
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Ala Pro Ala Ala Ala Thr Gly Gly Ser Thr Leu Pro Ser Gly Phe 
1               5                   10                  15      


Ser Val Phe Thr Thr Leu Pro Asp Leu Leu Phe Ile Phe Glu Phe Ile 
            20                  25                  30          


Phe Gly Gly Leu Val Trp Ile Leu Val Ala Ser Ser Leu Val Pro Trp 
        35                  40                  45              


Pro Leu Val Gln Gly Trp Val Met Phe Val Ser Val Phe Cys Phe Val 
    50                  55                  60                  


Ala Thr Thr Thr Leu Ile Ile Leu Tyr Ile Ile Gly Ala His Gly Gly 
65                  70                  75                  80  


Glu Thr Ser Trp Val Thr Leu Asp Ala Ala Tyr His Cys Thr Ala Ala 
                85                  90                  95      


Leu Phe Tyr Leu Ser Ala Ser Val Leu Glu Ala Leu Ala Thr Ile Thr 
            100                 105                 110         


Met Gln Asp Gly Phe Thr Tyr Arg His Tyr His Glu Asn Ile Ala Ala 
        115                 120                 125             


Val Val Phe Ser Tyr Ile Ala Thr Leu Leu Tyr Val Val His Ala Val 
    130                 135                 140                 


Phe Ser Leu Ile Arg Trp Lys Ser Ser 
145                 150             


<210>  310
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Ala Pro Ala Ala Ala Thr Gly Gly Ser Thr Leu Pro Ser Gly Phe 
1               5                   10                  15      


Ser Val Phe Thr Thr Leu Pro Asp Leu Leu Phe Ile Phe Glu Phe Ile 
            20                  25                  30          


Phe Gly Gly Leu Val Trp Ile Leu Val Ala Ser Ser Leu Val Pro Trp 
        35                  40                  45              


Pro Leu Val Gln Gly Trp Val Met Phe Val Ser Val Phe Cys Phe Val 
    50                  55                  60                  


Ala Thr Thr Thr Leu Ile Ile Leu Tyr Ile Ile Gly Ala His Gly Gly 
65                  70                  75                  80  


Glu Thr Ser Trp Val Thr Leu Val Phe Ser Tyr Ile Ala Thr Leu Leu 
                85                  90                  95      


Tyr Val Val His Ala Val Phe Ser Leu Ile Arg Trp Lys Ser Ser 
            100                 105                 110     


<210>  311
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Ala Pro Ala Ala Ala Thr Gly Gly Ser Thr Leu Pro Ser Gly Phe 
1               5                   10                  15      


Ser Val Phe Thr Thr Leu Pro Asp Leu Leu Phe Ile Phe Glu Phe Asp 
            20                  25                  30          


Ala Ala Tyr His Cys Thr Ala Ala Leu Phe Tyr Leu Ser Ala Ser Val 
        35                  40                  45              


Leu Glu Ala Leu Ala Thr Ile Thr Met Gln Asp Gly Phe Thr Tyr Arg 
    50                  55                  60                  


His Tyr His Glu Asn Ile Ala Ala Val Val Phe Ser Tyr Ile Ala Thr 
65                  70                  75                  80  


Leu Leu Tyr Val Val His Ala Val Phe Ser Leu Ile Arg Trp Lys Ser 
                85                  90                  95      


Ser 
    


<210>  312
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Ala Pro Ala Ala Ala Thr Gly Gly Ser Thr Leu Pro Ser Gly Phe 
1               5                   10                  15      


Ser Val Phe Thr Thr Leu Pro Asp Leu Leu Phe Ile Phe Glu Phe Val 
            20                  25                  30          


Phe Ser Tyr Ile Ala Thr Leu Leu Tyr Val Val His Ala Val Phe Ser 
        35                  40                  45              


Leu Ile Arg Trp Lys Ser Ser 
    50                  55  


<210>  313
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210>  314
<211>  1408
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Thr Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu 
        755                 760                 765             


Phe Cys Phe Ala Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn 
    770                 775                 780                 


Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala 
785                 790                 795                 800 


Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile 
                805                 810                 815     


Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro 
            820                 825                 830         


Leu Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr 
        835                 840                 845             


Phe Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys 
    850                 855                 860                 


Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly 
865                 870                 875                 880 


Asn Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly 
                885                 890                 895     


Asn Lys Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys 
            900                 905                 910         


Thr Val Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu 
        915                 920                 925             


Trp Lys Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln 
    930                 935                 940                 


Pro Asp Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser 
945                 950                 955                 960 


Thr Ala Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg 
                965                 970                 975     


Lys Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg 
            980                 985                 990         


Val His Thr Pro His Leu Asp Arg  Leu Val Ser Ala Arg  Ser Val Ser 
        995                 1000                 1005             


Pro Thr  Thr Glu Met Val Ser  Asn Glu Ser Val Asp  Tyr Arg Ala 
    1010                 1015                 1020             


Thr Phe  Pro Glu Asp Gln Phe  Pro Asn Ser Ser Gln  Asn Gly Ser 
    1025                 1030                 1035             


Cys Arg  Gln Val Gln Tyr Pro  Leu Thr Asp Met Ser  Pro Ile Leu 
    1040                 1045                 1050             


Thr Ser  Gly Asp Ser Asp Ile  Ser Ser Pro Leu Leu  Gln Asn Thr 
    1055                 1060                 1065             


Val His  Ile Asp Leu Ser Ala  Leu Asn Pro Glu Leu  Val Gln Ala 
    1070                 1075                 1080             


Val Gln  His Val Val Ile Gly  Pro Ser Ser Leu Ile  Val His Phe 
    1085                 1090                 1095             


Asn Glu  Val Ile Gly Arg Gly  His Phe Gly Cys Val  Tyr His Gly 
    1100                 1105                 1110             


Thr Leu  Leu Asp Asn Asp Gly  Lys Lys Ile His Cys  Ala Val Lys 
    1115                 1120                 1125             


Ser Leu  Asn Arg Ile Thr Asp  Ile Gly Glu Val Ser  Gln Phe Leu 
    1130                 1135                 1140             


Thr Glu  Gly Ile Ile Met Lys  Asp Phe Ser His Pro  Asn Val Leu 
    1145                 1150                 1155             


Ser Leu  Leu Gly Ile Cys Leu  Arg Ser Glu Gly Ser  Pro Leu Val 
    1160                 1165                 1170             


Val Leu  Pro Tyr Met Lys His  Gly Asp Leu Arg Asn  Phe Ile Arg 
    1175                 1180                 1185             


Asn Glu  Thr His Asn Pro Thr  Val Lys Asp Leu Ile  Gly Phe Gly 
    1190                 1195                 1200             


Leu Gln  Val Ala Lys Gly Met  Lys Tyr Leu Ala Ser  Lys Lys Phe 
    1205                 1210                 1215             


Val His  Arg Asp Leu Ala Ala  Arg Asn Cys Met Leu  Asp Glu Lys 
    1220                 1225                 1230             


Phe Thr  Val Lys Val Ala Asp  Phe Gly Leu Ala Arg  Asp Met Tyr 
    1235                 1240                 1245             


Asp Lys  Glu Tyr Tyr Ser Val  His Asn Lys Thr Gly  Ala Lys Leu 
    1250                 1255                 1260             


Pro Val  Lys Trp Met Ala Leu  Glu Ser Leu Gln Thr  Gln Lys Phe 
    1265                 1270                 1275             


Thr Thr  Lys Ser Asp Val Trp  Ser Phe Gly Val Leu  Leu Trp Glu 
    1280                 1285                 1290             


Leu Met  Thr Arg Gly Ala Pro  Pro Tyr Pro Asp Val  Asn Thr Phe 
    1295                 1300                 1305             


Asp Ile  Thr Val Tyr Leu Leu  Gln Gly Arg Arg Leu  Leu Gln Pro 
    1310                 1315                 1320             


Glu Tyr  Cys Pro Asp Pro Leu  Tyr Glu Val Met Leu  Lys Cys Trp 
    1325                 1330                 1335             


His Pro  Lys Ala Glu Met Arg  Pro Ser Phe Ser Glu  Leu Val Ser 
    1340                 1345                 1350             


Arg Ile  Ser Ala Ile Phe Ser  Thr Phe Ile Gly Glu  His Tyr Val 
    1355                 1360                 1365             


His Val  Asn Ala Thr Tyr Val  Asn Val Lys Cys Val  Ala Pro Tyr 
    1370                 1375                 1380             


Pro Ser  Leu Leu Ser Ser Glu  Asp Asn Ala Asp Asp  Glu Val Asp 
    1385                 1390                 1395             


Thr Arg  Pro Ala Ser Phe Trp  Glu Thr Ser 
    1400                 1405             


<210>  315
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Thr Gln Glu Pro Phe Arg Glu Glu Leu Ala Tyr Asp Arg Met Pro 
1               5                   10                  15      


Thr Leu Glu Arg Gly Arg Gln Asp Pro Ala Ser Tyr Ala Pro Asp Ala 
            20                  25                  30          


Lys Pro Ser Asp Leu Gln Leu Ser Lys Arg Leu Pro Pro Cys Phe Ser 
        35                  40                  45              


His Lys Thr Trp Val Phe Ser Val Leu Met Gly Ser Cys Leu Leu Val 
    50                  55                  60                  


Thr Ser Gly Phe Ser Leu Tyr Leu Gly Asn Val Phe Pro Ala Glu Met 
65                  70                  75                  80  


Asp Tyr Leu Arg Cys Ala Ala Gly Ser Cys Ile Pro Ser Ala Ile Val 
                85                  90                  95      


Ser Phe Thr Val Ser Arg Arg Asn Ala Asn Val Ile Pro Asn Phe Gln 
            100                 105                 110         


Ile Leu Phe Val Ser Thr Phe Ala Val Thr Thr Thr Cys Leu Ile Trp 
        115                 120                 125             


Phe Gly Cys Lys Leu Val Leu Asn Pro Ser Ala Ile Asn Ile Asn Phe 
    130                 135                 140                 


Asn Leu Ile Leu Leu Leu Leu Leu Glu Leu Leu Met Ala Ala Thr Val 
145                 150                 155                 160 


Ile Ile Ala Ala Arg Ser Ser Glu Glu Asp Cys Lys Lys Lys Lys Gly 
                165                 170                 175     


Ser Met Ser Asp Ser Ala Asn Ile Leu Asp Glu Val Pro Phe Pro Ala 
            180                 185                 190         


Arg Val Leu Lys Ser Tyr Ser Val Val Glu Val Ile Ala Gly Ile Ser 
        195                 200                 205             


Ala Val Leu Gly Gly Ile Ile Ala Leu Asn Val Asp Asp Ser Val Ser 
    210                 215                 220                 


Gly Pro His Leu Ser Val Thr Phe Phe Trp Ile Leu Val Ala Cys Phe 
225                 230                 235                 240 


Pro Ser Ala Ile Ala Ser His Val Ala Ala Glu Cys Pro Ser Lys Cys 
                245                 250                 255     


Leu Val Glu Val Leu Ile Ala Ile Ser Ser Leu Thr Ser Pro Leu Leu 
            260                 265                 270         


Phe Thr Ala Ser Gly Tyr Leu Ser Phe Ser Ile Met Arg Ile Val Glu 
        275                 280                 285             


Met Phe Lys Asp Tyr Pro Pro Ala Ile Lys Pro Ser Tyr Asp Val Leu 
    290                 295                 300                 


Leu Leu Leu Leu Leu Leu Val Leu Leu Leu Gln Ala Gly Leu Asn Thr 
305                 310                 315                 320 


Gly Thr Ala Ile Gln Cys Val Arg Phe Lys Val Ser Ala Arg Leu Gln 
                325                 330                 335     


Gly Ala Ser Trp Asp Thr Gln Asn Gly Pro Gln Glu Arg Leu Ala Gly 
            340                 345                 350         


Glu Val Ala Arg Ser Pro Leu Lys Glu Phe Asp Lys Glu Lys Ala Trp 
        355                 360                 365             


Arg Ala Val Val Val Gln Met Ala Gln 
    370                 375         


<210>  316
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Thr Gln Glu Pro Phe Arg Glu Glu Leu Ala Tyr Asp Arg Met Pro 
1               5                   10                  15      


Thr Leu Glu Arg Gly Arg Gln Asp Pro Ala Ser Tyr Ala Pro Asp Ala 
            20                  25                  30          


Lys Pro Ser Asp Leu Gln Leu Ser Lys Arg Leu Pro Pro Cys Phe Ser 
        35                  40                  45              


His Lys Thr Trp Val Phe Ser Val Leu Met Gly Ser Cys Leu Leu Val 
    50                  55                  60                  


Thr Ser Gly Phe Ser Leu Tyr Leu Gly Asn Val Phe Pro Ala Glu Met 
65                  70                  75                  80  


Asp Tyr Leu Arg Cys Ala Ala Gly Ser Cys Ile Pro Ser Ala Ile Val 
                85                  90                  95      


Ser Phe Thr Val Ser Arg Arg Asn Ala Asn Val Ile Pro Asn Phe Gln 
            100                 105                 110         


Ile Leu Phe Val Ser Thr Phe Ala Val Thr Thr Thr Cys Leu Ile Trp 
        115                 120                 125             


Phe Gly Cys Lys Leu Val Leu Asn Pro Ser Ala Ile Asn Ile Asn Phe 
    130                 135                 140                 


Asn Leu Ile Leu Leu Leu Leu Leu Glu Leu Leu Met Ala Ala Thr Val 
145                 150                 155                 160 


Ile Ile Ala Ala Arg Ser Ser Glu Glu Asp Cys Lys Lys Lys Lys Gly 
                165                 170                 175     


Ser Met Ser Asp Ser Ala Asn Ile Leu Asp Glu Val Pro Phe Pro Ala 
            180                 185                 190         


Arg Val Leu Lys Ser Tyr Ser Val Val Glu Val Ile Ala Gly Ile Ser 
        195                 200                 205             


Ala Val Leu Gly Gly Ile Ile Ala Leu Asn Val Asp Asp Ser Val Ser 
    210                 215                 220                 


Gly Pro His Leu Ser Val Thr Phe Phe Trp Ile Leu Val Ala Cys Phe 
225                 230                 235                 240 


Pro Ser Ala Ile Ala Ser His Val Ala Ala Glu Cys Pro Ser Lys Cys 
                245                 250                 255     


Leu Val Glu Val Leu Ile Ala Ile Ser Ser Leu Thr Ser Pro Leu Leu 
            260                 265                 270         


Phe Thr Ala Ser Gly Tyr Leu Ser Phe Ser Ile Met Arg Ile Val Glu 
        275                 280                 285             


Met Phe Lys Asp Tyr Pro Pro Ala Ile Lys Pro Ser Tyr Asp Val Leu 
    290                 295                 300                 


Leu Leu Leu Leu Leu Leu Val Leu Leu Leu Gln Ala Gly Leu Asn Thr 
305                 310                 315                 320 


Gly Thr Ala Ile Gln Cys Val Arg Phe Lys Val Ser Ala Arg Leu Gln 
                325                 330                 335     


Gly Ala Ser Trp Asp Thr Gln Asn Gly Pro Gln Glu Arg Leu Ala Gly 
            340                 345                 350         


Glu Val Ala Arg Ser Pro Leu Lys Glu Phe Asp Lys Glu Lys Ala Trp 
        355                 360                 365             


Arg Ala Val Val Val Gln Met Ala Gln 
    370                 375         


<210>  317
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Ser Pro Ala Pro Arg Pro Pro Arg Cys Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser 
            20                  25                  30          


Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly 
        35                  40                  45              


Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala 
    50                  55                  60                  


Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala 
65                  70                  75                  80  


Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro 
                85                  90                  95      


Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr 
            100                 105                 110         


Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile 
        115                 120                 125             


Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile 
    130                 135                 140                 


Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg 
145                 150                 155                 160 


Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp 
                165                 170                 175     


Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe 
            180                 185                 190         


Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn 
        195                 200                 205             


Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg 
    210                 215                 220                 


Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu 
225                 230                 235                 240 


Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile 
                245                 250                 255     


Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro 
            260                 265                 270         


Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly 
        275                 280                 285             


Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser 
    290                 295                 300                 


Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp 
305                 310                 315                 320 


Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe 
                325                 330                 335     


Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly 
            340                 345                 350         


Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile 
        355                 360                 365             


Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly 
    370                 375                 380                 


Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro 
385                 390                 395                 400 


Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp 
                405                 410                 415     


Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly 
            420                 425                 430         


Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu 
        435                 440                 445             


Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg 
    450                 455                 460                 


Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly 
465                 470                 475                 480 


Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly 
                485                 490                 495     


Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly 
            500                 505                 510         


Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu 
        515                 520                 525             


Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val Leu 
    530                 535                 540                 


Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe 
545                 550                 555                 560 


Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln Arg 
                565                 570                 575     


Ser Leu Leu Asp Lys Val 
            580         


<210>  318
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  319
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  319

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  320
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210>  321
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
145                 150                 155                 160 


Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 
                165                 170                 175     


Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 
            180                 185                 190         


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
        195                 200                 205             


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
    210                 215                 220                 


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
225                 230                 235                 240 


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
                245                 250                 255     


Val Ala Ala Thr Ser Ala Asn Leu 
            260                 


<210>  322
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile 
65                  70                  75                  80  


Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro 
                85                  90                  95      


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
            100                 105                 110         


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
        115                 120                 125             


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
    130                 135                 140                 


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
145                 150                 155                 160 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
                165                 170                 175     


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
            180                 185                 190         


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
        195                 200                 205             


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
    210                 215                 220                 


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
225                 230                 235                 240 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
                245                 250                 255 


<210>  323
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  323

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 
65                  70                  75                  80  


Trp Ala Ser Pro Ile Leu Ser Ser Val Ser Asp Val Pro Phe Pro Phe 
                85                  90                  95      


Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 
            100                 105                 110         


Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 
        115                 120                 125             


Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 
    130                 135                 140                 


Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 
145                 150                 155                 160 


His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 
                165                 170                 175     


Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 
            180                 185                 190         


Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
        195                 200             


<210>  324
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln 
65                  70                  75                  80  


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                85                  90                  95      


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            100                 105                 110         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        115                 120                 125             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    130                 135                 140                 


Ala Thr Ser Ala Asn Leu 
145                 150 


<210>  325
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  325

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
                85                  90                  95      


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
            100                 105                 110         


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
        115                 120                 125             


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
    130                 135                 140                 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
145                 150                 155                 


<210>  326
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 
65                  70                  75                  80  


Trp Ala Ser Pro Ile Leu Ser Ser Val Trp Gly Trp Gly Ala Arg Leu 
                85                  90                  95      


Gly His Arg Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His 
            100                 105                 110         


Cys Leu Ser His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu 
        115                 120                 125             


Arg Ala Ala Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu 
    130                 135                 140                 


Arg Val Pro His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 
145                 150                 155             


<210>  327
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  327

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His 
                165                 170                 175     


Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu 
            180                 185                 190         


Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys 
        195                 200                 205             


Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr 
    210                 215                 220                 


Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser 
225                 230                 235                 240 


Thr Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu 
                245                 250                 255     


Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu 
            260                 265                 270         


Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu 
        275                 280                 285             


Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly 
    290                 295                 300                 


Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val 
305                 310                 315                 320 


Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 
                325                 330                 335     


Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 
            340                 345                 350         


Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe 
        355                 360                 365             


Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 
    370                 375                 380                 


Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 
385                 390                 395                 400 


Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 
                405                 410                 415     


Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 
            420                 425                 430         


His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 
        435                 440                 445             


Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 
    450                 455                 460                 


Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
465                 470                 475 


<210>  328
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Val Ser 
    50                  55                  60                  


Met Thr Ser Ser Val Leu Ser Ser His Ser Pro Gly Ser Gly Ser Ser 
65                  70                  75                  80  


Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro Ala Thr Glu Pro Ala 
                85                  90                  95      


Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val Thr Ser Val Pro Val 
            100                 105                 110         


Thr Arg Pro Ala Leu Gly Ser Thr Thr Pro Pro Ala His Asp Val Thr 
        115                 120                 125             


Ser Ala Pro Asp Asn Lys Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
    130                 135                 140                 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
145                 150                 155                 160 


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn Arg Pro Ala 
                165                 170                 175     


Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser Ala Ser Gly 
            180                 185                 190         


Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala 
        195                 200                 205             


Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro 
    210                 215                 220                 


Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys 
225                 230                 235                 240 


Thr Asp Ala Ser Ser Thr His His Ser Thr Val Pro Pro Leu Thr Ser 
                245                 250                 255     


Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe 
            260                 265                 270         


Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu 
        275                 280                 285             


Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu 
    290                 295                 300                 


Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn 
305                 310                 315                 320 


Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe 
                325                 330                 335     


Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln 
            340                 345                 350         


Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val 
        355                 360                 365             


Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    370                 375                 380                 


Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 
385                 390                 395                 400 


Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 
                405                 410                 415     


Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 
            420                 425                 430         


His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 
        435                 440                 445             


Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 
    450                 455                 460                 


Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 
465                 470                 475                 480 


Ser Ala Asn Leu 
                


<210>  329
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  329

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 
    50                  55                  60                  


Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 
                85                  90                  95      


Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly 
            100                 105                 110         


Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val 
        115                 120                 125             


Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val 
    130                 135                 140                 


Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn 
145                 150                 155                 160 


Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser 
                165                 170                 175     


Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val 
            180                 185                 190         


Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu 
        195                 200                 205             


Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe 
    210                 215                 220                 


Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His 
225                 230                 235                 240 


Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr 
                245                 250                 255     


Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn 
            260                 265                 270         


Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
        275                 280         


<210>  330
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Trp Gly Trp Gly Ala Arg Leu Gly His Arg 
145                 150                 155                 160 


Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His Cys Leu Ser 
                165                 170                 175     


His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala 
            180                 185                 190         


Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro 
        195                 200                 205             


His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 
    210                 215                 


<210>  331
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr 
    50                  55                  60                  


Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly 
65                  70                  75                  80  


Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
                85                  90                  95      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            100                 105                 110         


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        115                 120                 125             


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile 
    130                 135                 140                 


Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr 
145                 150                 155                 160 


Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln 
                165                 170                 175     


Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr 
            180                 185                 190         


Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp 
        195                 200                 205             


Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu 
    210                 215                 220                 


Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
225                 230                 235             


<210>  332
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser 
            20                  25                  30          


Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr Lys Gln Gly Gly Phe 
        35                  40                  45              


Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln 
    50                  55                  60                  


Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu 
65                  70                  75                  80  


Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu 
                85                  90                  95      


Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala 
            100                 105                 110         


Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu 
        115                 120                 125             


Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala 
    130                 135                 140                 


Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro 
145                 150                 155                 160 


Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr 
                165                 170                 175     


His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu 
            180                 185                 190         


Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro 
        195                 200                 205             


Ala Val Ala Ala Thr Ser Ala Asn Leu 
    210                 215         


<210>  333
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Leu 
    50                  55                  60                  


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
65                  70                  75                  80  


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
                85                  90                  95      


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
            100                 105                 110         


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
        115                 120                 125             


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
    130                 135                 140                 


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
145                 150                 155                 160 


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
                165                 170                 175     


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
            180                 185                 190         


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
        195                 200                 205             


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
    210                 215                 220                 


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
225                 230                 235                 240 


Leu 
    


<210>  334
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 
    50                  55                  60                  


Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Trp Pro 
65                  70                  75                  80  


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
                85                  90                  95      


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
            100                 105                 110         


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
        115                 120                 125             


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
    130                 135                 140                 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
145                 150                 155                 160 


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
                165                 170                 175     


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
            180                 185                 190         


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
        195                 200                 205             


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
    210                 215                 220                 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
225                 230                 235                 


<210>  335
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Gly Cys 
145                 150                 155                 160 


Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala Gly His Leu Ser Ser 
                165                 170                 175     


Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro His Leu Pro His Pro 
            180                 185                 190         


Trp Ala Leu Cys Ala Pro 
        195             


<210>  336
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Trp Pro Gly Ser Val Val Val Gln Leu Thr Leu 
65                  70                  75                  80  


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
                85                  90                  95      


Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser 
            100                 105                 110         


Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly 
        115                 120                 125             


Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val 
    130                 135                 140                 


Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln 
145                 150                 155                 160 


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                165                 170                 175     


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            180                 185                 190         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        195                 200                 205             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    210                 215                 220                 


Ala Thr Ser Ala Asn Leu 
225                 230 


<210>  337
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala 
                85                  90                  95      


Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu 
            100                 105                 110         


Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu 
        115                 120                 125             


Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro 
    130                 135                 140                 


Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg 
145                 150                 155                 160 


Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser 
                165                 170                 175     


Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
            180                 185                 


<210>  338
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 
    50                  55                  60                  


Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Cys Phe 
65                  70                  75                  80  


Cys Arg Phe Ile Asn Lys Gly Val Phe Trp Ala Ser Pro Ile Leu Ser 
                85                  90                  95      


Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
            100                 105                 110         


Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 
        115                 120                 125             


Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 
    130                 135                 140                 


Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 
145                 150                 155                 160 


His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 
                165                 170                 175     


Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 
            180                 185                 190         


Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 
        195                 200                 205             


Ser Ala Asn Leu 
    210         


<210>  339
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  339

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 
    50                  55                  60                  


Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 
                85                  90                  95      


Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn 
            100                 105                 110         


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
        115                 120                 125             


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
    130                 135                 140                 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
145                 150                 155                 160 


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
                165                 170                 175     


Leu 
    


<210>  340
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
145                 150                 155                 160 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
            180                 185                 190         


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
        195                 200                 205             


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
    210                 215                 220                 


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
                245                 250                 255     


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
            260                 265                 270         


Leu 
    


<210>  341
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  341

Met Lys Ala Ile Ile His Leu Thr Leu Leu Ala Leu Leu Ser Val Asn 
1               5                   10                  15      


Thr Ala Thr Asn Gln Gly Asn Ser Ala Asp Ala Val Thr Thr Thr Glu 
            20                  25                  30          


Thr Ala Thr Ser Gly Pro Thr Val Ala Ala Ala Asp Thr Thr Glu Thr 
        35                  40                  45              


Asn Phe Pro Glu Thr Ala Ser Thr Thr Ala Asn Thr Pro Ser Phe Pro 
    50                  55                  60                  


Thr Ala Thr Ser Pro Ala Pro Pro Ile Ile Ser Thr His Ser Ser Ser 
65                  70                  75                  80  


Thr Ile Pro Thr Pro Ala Pro Pro Ile Ile Ser Thr His Ser Ser Ser 
                85                  90                  95      


Thr Ile Pro Ile Pro Thr Ala Ala Asp Ser Glu Ser Thr Thr Asn Val 
            100                 105                 110         


Asn Ser Leu Ala Thr Ser Asp Ile Ile Thr Ala Ser Ser Pro Asn Asp 
        115                 120                 125             


Gly Leu Ile Thr Met Val Pro Ser Glu Thr Gln Ser Asn Asn Glu Met 
    130                 135                 140                 


Ser Pro Thr Thr Glu Asp Asn Gln Ser Ser Gly Pro Pro Thr Gly Thr 
145                 150                 155                 160 


Ala Leu Leu Glu Thr Ser Thr Leu Asn Ser Thr Gly Pro Ser Asn Pro 
                165                 170                 175     


Cys Gln Asp Asp Pro Cys Ala Asp Asn Ser Leu Cys Val Lys Leu His 
            180                 185                 190         


Asn Thr Ser Phe Cys Leu Cys Leu Glu Gly Tyr Tyr Tyr Asn Ser Ser 
        195                 200                 205             


Thr Cys Lys Lys Gly Lys Val Phe Pro Gly Lys Ile Ser Val Thr Val 
    210                 215                 220                 


Ser Glu Thr Phe Asp Pro Glu Glu Lys His Ser Met Ala Tyr Gln Asp 
225                 230                 235                 240 


Leu His Ser Glu Ile Thr Ser Leu Phe Lys Asp Val Phe Gly Thr Ser 
                245                 250                 255     


Val Tyr Gly Gln Thr Val Ile Leu Thr Val Ser Thr Ser Leu Ser Pro 
            260                 265                 270         


Arg Ser Glu Met Arg Ala Asp Asp Lys Phe Val Asn Val Thr Ile Val 
        275                 280                 285             


Thr Ile Leu Ala Glu Thr Thr Ser Asp Asn Glu Lys Thr Val Thr Glu 
    290                 295                 300                 


Lys Ile Asn Lys Ala Ile Arg Ser Ser Ser Ser Asn Phe Leu Asn Tyr 
305                 310                 315                 320 


Asp Leu Thr Leu Arg Cys Asp Tyr Tyr Gly Cys Asn Gln Thr Ala Asp 
                325                 330                 335     


Asp Cys Leu Asn Gly Leu Ala Cys Asp Cys Lys Ser Asp Leu Gln Arg 
            340                 345                 350         


Pro Asn Pro Gln Ser Pro Phe Cys Val Ala Ser Ser Leu Lys Cys Pro 
        355                 360                 365             


Asp Ala Cys Asn Ala Gln His Lys Gln Cys Leu Ile Lys Lys Ser Gly 
    370                 375                 380                 


Gly Ala Pro Glu Cys Ala Cys Val Pro Gly Tyr Gln Glu Asp Ala Asn 
385                 390                 395                 400 


Gly Asn Cys Gln Lys Cys Ala Phe Gly Tyr Ser Gly Leu Asp Cys Lys 
                405                 410                 415     


Asp Lys Phe Gln Leu Ile Leu Thr Ile Val Gly Thr Ile Ala Gly Ile 
            420                 425                 430         


Val Ile Leu Ser Met Ile Ile Ala Leu Ile Val Thr Ala Arg Ser Asn 
        435                 440                 445             


Asn Lys Thr Lys His Ile Glu Glu Glu Asn Leu Ile Asp Glu Asp Phe 
    450                 455                 460                 


Gln Asn Leu Lys Leu Arg Ser Thr Gly Phe Thr Asn Leu Gly Ala Glu 
465                 470                 475                 480 


Gly Ser Val Phe Pro Lys Val Arg Ile Thr Ala Ser Arg Asp Ser Gln 
                485                 490                 495     


Met Gln Asn Pro Tyr Ser Arg His Ser Ser Met Pro Arg Pro Asp Tyr 
            500                 505                 510         


<210>  342
<211>  1738
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala Gln Pro Val Thr 
1               5                   10                  15      


Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala Asp Ile Leu Trp 
            20                  25                  30          


Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile Cys Ala Ile Ile 
        35                  40                  45              


Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr Phe Glu His Tyr 
    50                  55                  60                  


Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr Leu Leu Met Phe 
65                  70                  75                  80  


Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile Arg Gly Ile Val 
                85                  90                  95      


Lys Gly Asp Ser Ser Tyr Val Lys Asp Arg Trp Cys Val Phe Asp Gly 
            100                 105                 110         


Phe Met Val Phe Cys Leu Trp Val Ser Leu Val Leu Gln Val Phe Glu 
        115                 120                 125             


Ile Ala Asp Ile Val Asp Gln Met Ser Pro Trp Gly Met Leu Arg Ile 
    130                 135                 140                 


Pro Arg Pro Leu Ile Met Ile Arg Ala Phe Arg Ile Tyr Phe Arg Phe 
145                 150                 155                 160 


Glu Leu Pro Arg Thr Arg Ile Thr Asn Ile Leu Lys Arg Ser Gly Glu 
                165                 170                 175     


Gln Ile Trp Ser Val Ser Ile Phe Leu Leu Phe Phe Leu Leu Leu Tyr 
            180                 185                 190         


Gly Ile Leu Gly Val Gln Met Phe Gly Thr Phe Thr Tyr His Cys Val 
        195                 200                 205             


Val Asn Asp Thr Lys Pro Gly Asn Val Thr Trp Asn Ser Leu Ala Ile 
    210                 215                 220                 


Pro Asp Thr His Cys Ser Pro Glu Leu Glu Glu Gly Tyr Gln Cys Pro 
225                 230                 235                 240 


Pro Gly Phe Lys Cys Met Asp Leu Glu Asp Leu Gly Leu Ser Arg Gln 
                245                 250                 255     


Glu Leu Gly Tyr Ser Gly Phe Asn Glu Ile Gly Thr Ser Ile Phe Thr 
            260                 265                 270         


Val Tyr Glu Ala Ala Ser Gln Glu Gly Trp Val Phe Leu Met Tyr Arg 
        275                 280                 285             


Ala Ile Asp Ser Phe Pro Arg Trp Arg Ser Tyr Phe Tyr Phe Ile Thr 
    290                 295                 300                 


Leu Ile Phe Phe Leu Ala Trp Leu Val Lys Asn Val Phe Ile Ala Val 
305                 310                 315                 320 


Ile Ile Glu Thr Phe Ala Glu Ile Arg Val Gln Phe Gln Gln Met Trp 
                325                 330                 335     


Gly Ser Arg Ser Ser Thr Thr Ser Thr Ala Thr Thr Gln Met Phe His 
            340                 345                 350         


Glu Asp Ala Ala Gly Gly Trp Gln Leu Val Ala Val Asp Val Asn Lys 
        355                 360                 365             


Pro Gln Gly Arg Ala Pro Ala Cys Leu Gln Lys Met Met Arg Ser Ser 
    370                 375                 380                 


Val Phe His Met Phe Ile Leu Ser Met Val Thr Val Asp Val Ile Val 
385                 390                 395                 400 


Ala Ala Ser Asn Tyr Tyr Lys Gly Glu Asn Phe Arg Arg Gln Tyr Asp 
                405                 410                 415     


Glu Phe Tyr Leu Ala Glu Val Ala Phe Thr Val Leu Phe Asp Leu Glu 
            420                 425                 430         


Ala Leu Leu Lys Ile Trp Cys Leu Gly Phe Thr Gly Tyr Ile Ser Ser 
        435                 440                 445             


Ser Leu His Lys Phe Glu Leu Leu Leu Val Ile Gly Thr Thr Leu His 
    450                 455                 460                 


Val Tyr Pro Asp Leu Tyr His Ser Gln Phe Thr Tyr Phe Gln Val Leu 
465                 470                 475                 480 


Arg Val Val Arg Leu Ile Lys Ile Ser Pro Ala Leu Glu Asp Phe Val 
                485                 490                 495     


Tyr Lys Ile Phe Gly Pro Gly Lys Lys Leu Gly Ser Leu Val Val Phe 
            500                 505                 510         


Thr Ala Ser Leu Leu Ile Val Met Ser Ala Ile Ser Leu Gln Met Phe 
        515                 520                 525             


Cys Phe Val Glu Glu Leu Asp Arg Phe Thr Thr Phe Pro Arg Ala Phe 
    530                 535                 540                 


Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val Met 
545                 550                 555                 560 


Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val Ala 
                565                 570                 575     


Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu Ser 
            580                 585                 590         


Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp Leu 
        595                 600                 605             


Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr Lys 
    610                 615                 620                 


Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn Arg 
625                 630                 635                 640 


Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val Pro 
                645                 650                 655     


Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln Gln 
            660                 665                 670         


Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser Ser 
        675                 680                 685             


Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile Asp 
    690                 695                 700                 


Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu Leu 
705                 710                 715                 720 


Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg Gln 
                725                 730                 735     


Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg Ser 
            740                 745                 750         


Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu Arg 
        755                 760                 765             


His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu Thr 
    770                 775                 780                 


Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln Arg 
785                 790                 795                 800 


Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala Glu 
                805                 810                 815     


Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro Tyr 
            820                 825                 830         


Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg Asn 
        835                 840                 845             


Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr Asp 
    850                 855                 860                 


Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr Asp 
865                 870                 875                 880 


Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val Thr 
                885                 890                 895     


Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg Val 
            900                 905                 910         


Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile Phe 
        915                 920                 925             


Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe Phe 
    930                 935                 940                 


Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile Phe 
945                 950                 955                 960 


Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn Val 
                965                 970                 975     


Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu Arg 
            980                 985                 990         


Pro Leu Arg Ile Phe Lys Leu Val  Pro Gln Met Arg Lys  Val Val Arg 
        995                 1000                 1005             


Glu Leu  Phe Ser Gly Phe Lys  Glu Ile Phe Leu Val  Ser Ile Leu 
    1010                 1015                 1020             


Leu Leu  Thr Leu Met Leu Val  Phe Ala Ser Phe Gly  Val Gln Leu 
    1025                 1030                 1035             


Phe Ala  Gly Lys Leu Ala Lys  Cys Asn Asp Pro Asn  Ile Ile Arg 
    1040                 1045                 1050             


Arg Glu  Asp Cys Asn Gly Ile  Phe Arg Ile Asn Val  Ser Val Ser 
    1055                 1060                 1065             


Lys Asn  Leu Asn Leu Lys Leu  Arg Pro Gly Glu Lys  Lys Pro Gly 
    1070                 1075                 1080             


Phe Trp  Val Pro Arg Val Trp  Ala Asn Pro Arg Asn  Phe Asn Phe 
    1085                 1090                 1095             


Asp Asn  Val Gly Asn Ala Met  Leu Ala Leu Phe Glu  Val Leu Ser 
    1100                 1105                 1110             


Leu Lys  Gly Trp Val Glu Val  Arg Asp Val Ile Ile  His Arg Val 
    1115                 1120                 1125             


Gly Pro  Ile His Gly Ile Tyr  Ile His Val Phe Val  Phe Leu Gly 
    1130                 1135                 1140             


Cys Met  Ile Gly Leu Thr Leu  Phe Val Gly Val Val  Ile Ala Asn 
    1145                 1150                 1155             


Phe Asn  Glu Asn Lys Gly Thr  Ala Leu Leu Thr Val  Asp Gln Arg 
    1160                 1165                 1170             


Arg Trp  Glu Asp Leu Lys Ser  Arg Leu Lys Ile Ala  Gln Pro Leu 
    1175                 1180                 1185             


His Leu  Pro Pro Arg Pro Asp  Asn Asp Gly Phe Arg  Ala Lys Met 
    1190                 1195                 1200             


Tyr Asp  Ile Thr Gln His Pro  Phe Phe Lys Arg Thr  Ile Ala Leu 
    1205                 1210                 1215             


Leu Val  Leu Ala Gln Ser Val  Leu Leu Ser Val Lys  Trp Asp Val 
    1220                 1225                 1230             


Glu Asp  Pro Val Thr Val Pro  Leu Ala Thr Met Ser  Val Val Phe 
    1235                 1240                 1245             


Thr Phe  Ile Phe Val Leu Glu  Val Thr Met Lys Ile  Ile Ala Met 
    1250                 1255                 1260             


Ser Pro  Ala Gly Phe Trp Gln  Ser Arg Arg Asn Arg  Tyr Asp Leu 
    1265                 1270                 1275             


Leu Val  Thr Ser Leu Gly Val  Val Trp Val Val Leu  His Phe Ala 
    1280                 1285                 1290             


Leu Leu  Asn Ala Tyr Thr Tyr  Met Met Gly Ala Cys  Val Ile Val 
    1295                 1300                 1305             


Phe Arg  Phe Phe Ser Ile Cys  Gly Lys His Val Thr  Leu Lys Met 
    1310                 1315                 1320             


Leu Leu  Leu Thr Val Val Val  Ser Met Tyr Lys Ser  Phe Phe Ile 
    1325                 1330                 1335             


Ile Val  Gly Met Phe Leu Leu  Leu Leu Cys Tyr Ala  Phe Ala Gly 
    1340                 1345                 1350             


Val Val  Leu Phe Gly Thr Val  Lys Tyr Gly Glu Asn  Ile Asn Arg 
    1355                 1360                 1365             


His Ala  Asn Phe Ser Ser Ala  Gly Lys Ala Ile Thr  Val Leu Phe 
    1370                 1375                 1380             


Arg Ile  Val Thr Gly Glu Asp  Trp Asn Lys Ile Met  His Asp Cys 
    1385                 1390                 1395             


Met Val  Gln Pro Pro Phe Cys  Thr Pro Asp Glu Phe  Thr Tyr Trp 
    1400                 1405                 1410             


Ala Thr  Asp Cys Gly Asn Tyr  Ala Gly Ala Leu Met  Tyr Phe Cys 
    1415                 1420                 1425             


Ser Phe  Tyr Val Ile Ile Ala  Tyr Ile Met Leu Asn  Leu Leu Val 
    1430                 1435                 1440             


Ala Ile  Ile Val Glu Asn Phe  Ser Leu Phe Tyr Ser  Thr Glu Glu 
    1445                 1450                 1455             


Asp Gln  Leu Leu Ser Tyr Asn  Asp Leu Arg His Phe  Gln Ile Ile 
    1460                 1465                 1470             


Trp Asn  Met Val Asp Asp Lys  Arg Glu Gly Val Ile  Pro Thr Phe 
    1475                 1480                 1485             


Arg Val  Lys Phe Leu Leu Arg  Leu Leu Arg Gly Arg  Leu Glu Val 
    1490                 1495                 1500             


Asp Leu  Asp Lys Asp Lys Leu  Leu Phe Lys His Met  Cys Tyr Glu 
    1505                 1510                 1515             


Met Glu  Arg Leu His Asn Gly  Gly Asp Val Thr Phe  His Asp Val 
    1520                 1525                 1530             


Leu Ser  Met Leu Ser Tyr Arg  Ser Val Asp Ile Arg  Lys Ser Leu 
    1535                 1540                 1545             


Gln Leu  Glu Glu Leu Leu Ala  Arg Glu Gln Leu Glu  Tyr Thr Ile 
    1550                 1555                 1560             


Glu Glu  Glu Val Ala Lys Gln  Thr Ile Arg Met Trp  Leu Lys Lys 
    1565                 1570                 1575             


Cys Leu  Lys Arg Ile Arg Ala  Lys Gln Gln Gln Ser  Cys Ser Ile 
    1580                 1585                 1590             


Ile His  Ser Leu Arg Glu Ser  Gln Gln Gln Glu Leu  Ser Arg Phe 
    1595                 1600                 1605             


Leu Asn  Pro Pro Ser Ile Glu  Thr Thr Gln Pro Ser  Glu Asp Thr 
    1610                 1615                 1620             


Asn Ala  Asn Ser Gln Asp Asn  Ser Met Gln Pro Glu  Thr Ser Ser 
    1625                 1630                 1635             


Gln Gln  Gln Leu Leu Ser Pro  Thr Leu Ser Asp Arg  Gly Gly Ser 
    1640                 1645                 1650             


Arg Gln  Asp Ala Ala Asp Ala  Gly Lys Pro Gln Arg  Lys Phe Gly 
    1655                 1660                 1665             


Gln Trp  Arg Leu Pro Ser Ala  Pro Lys Pro Ile Ser  His Ser Val 
    1670                 1675                 1680             


Ser Ser  Val Asn Leu Arg Phe  Gly Gly Arg Thr Thr  Met Lys Ser 
    1685                 1690                 1695             


Val Val  Cys Lys Met Asn Pro  Met Thr Asp Ala Ala  Ser Cys Gly 
    1700                 1705                 1710             


Ser Glu  Val Lys Lys Trp Trp  Thr Arg Gln Leu Thr  Val Glu Ser 
    1715                 1720                 1725             


Asp Glu  Ser Gly Asp Asp Leu  Leu Asp Ile 
    1730                 1735             


<210>  343
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Lys Val Leu Gly His Arg Leu Glu Leu Leu Thr Gly Leu Leu Leu 
1               5                   10                  15      


His Asp Val Thr Met Ala Gly Leu Gln Glu Leu Arg Phe Pro Glu Glu 
            20                  25                  30          


Lys Pro Leu Leu Arg Gly Gln Asp Ala Thr Glu Leu Glu Ser Ser Asp 
        35                  40                  45              


Ala Phe Leu Leu Ala Ala Asp Thr Asp Trp Lys Glu His Asp Ile Glu 
    50                  55                  60                  


Thr Pro Tyr Gly Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly 
65                  70                  75                  80  


Asn Arg Pro Ala Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys 
                85                  90                  95      


Leu Cys Phe Asn Thr Phe Phe Asn Phe Glu Asp Met Gln Glu Ile Thr 
            100                 105                 110         


Lys His Phe Val Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly 
        115                 120                 125             


Ala Ser Gln Phe Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu 
    130                 135                 140                 


Ala Ala Met Leu Pro Ser Val Val Gln His Phe Gly Phe Lys Tyr Val 
145                 150                 155                 160 


Ile Gly Ile Gly Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala 
                165                 170                 175     


Leu Ile Phe Pro Asp Leu Val Glu Gly Leu Val Leu Val Asn Ile Asp 
            180                 185                 190         


Pro Asn Gly Lys Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly 
        195                 200                 205             


Leu Thr Ser Thr Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln 
    210                 215                 220                 


Glu Glu Leu Val Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln 
225                 230                 235                 240 


Ile Gly Asn Val Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met 
                245                 250                 255     


Tyr Asn Ser Arg Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro 
            260                 265                 270         


Asn Ala Lys Thr Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn 
        275                 280                 285             


Ala Pro Ala Glu Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro 
    290                 295                 300                 


Thr Thr Thr Thr Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln 
305                 310                 315                 320 


Val Thr Gln Pro Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln 
                325                 330                 335     


Gly Met Gly Tyr Met Pro Ser Ala Ser Met Thr Arg Leu Ala Arg Ser 
            340                 345                 350         


Arg Thr Ala Ser Leu Thr Ser Ala Ser Ser Val Asp Gly Ser Arg Pro 
        355                 360                 365             


Gln Ala Cys Thr His Ser Glu Ser Ser Glu Gly Leu Gly Gln Val Asn 
    370                 375                 380                 


His Thr Met Glu Val Ser Cys 
385                 390     


<210>  344
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Pro Glu Cys Trp Asp Gly Val Gly Glu Gly Asn Ala Gly Ala Val 
1               5                   10                  15      


Lys Leu Ala Gly Leu Gly Asp Pro Arg Trp Ser Pro Gly His Leu Leu 
            20                  25                  30          


Ser Pro Gly His Gln Glu His Asp Ile Glu Thr Pro Tyr Gly Leu Leu 
        35                  40                  45              


His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg Pro Ala Ile Leu 
    50                  55                  60                  


Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys Phe Asn Thr Phe 
65                  70                  75                  80  


Phe Asn Phe Glu Asp Met Gln Glu Ile Thr Lys His Phe Val Val Cys 
                85                  90                  95      


His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser Gln Phe Pro Gln 
            100                 105                 110         


Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Ala Met Leu Pro Ser 
        115                 120                 125             


Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly Ile Gly Val Gly 
    130                 135                 140                 


Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile Phe Pro Asp Leu 
145                 150                 155                 160 


Val Glu Gly Leu Val Leu Val Asn Ile Asp Pro Asn Gly Lys Gly Trp 
                165                 170                 175     


Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr Ser Thr Leu Pro 
            180                 185                 190         


Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu Leu Val Asn Asn 
        195                 200                 205             


Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Gly Asn Val Val Asn 
    210                 215                 220                 


Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn Ser Arg Arg Asp 
225                 230                 235                 240 


Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala Lys Thr Leu Arg 
                245                 250                 255     


Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro Ala Glu Asp Gly 
            260                 265                 270         


Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr Thr Thr Phe Leu 
        275                 280                 285             


Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr Gln Pro Gly Lys 
    290                 295                 300                 


Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr Met Pro 
305                 310                 315                 320 


Ser Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr Ala Ser Leu Thr 
                325                 330                 335     


Ser Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Ala Cys Thr His Ser 
            340                 345                 350         


Glu Ser Ser Glu Gly Leu Gly Gln Val Asn His Thr Met Glu Val Ser 
        355                 360                 365             


Cys 
    


<210>  345
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Pro Glu Cys Trp Asp Gly Arg Ser Gln Glu Arg Arg Leu Pro Arg 
1               5                   10                  15      


Val Ser Ser Thr Val Ser Pro Leu Gln Glu His Asp Ile Glu Thr Pro 
            20                  25                  30          


Tyr Gly Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg 
        35                  40                  45              


Pro Ala Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys 
    50                  55                  60                  


Phe Asn Thr Phe Phe Asn Phe Glu Asp Met Gln Glu Ile Thr Lys His 
65                  70                  75                  80  


Phe Val Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser 
                85                  90                  95      


Gln Phe Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Ala 
            100                 105                 110         


Met Leu Pro Ser Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly 
        115                 120                 125             


Ile Gly Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile 
    130                 135                 140                 


Phe Pro Asp Leu Val Glu Gly Leu Val Leu Val Asn Ile Asp Pro Asn 
145                 150                 155                 160 


Gly Lys Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr 
                165                 170                 175     


Ser Thr Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu 
            180                 185                 190         


Leu Val Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Gly 
        195                 200                 205             


Asn Val Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn 
    210                 215                 220                 


Ser Arg Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala 
225                 230                 235                 240 


Lys Thr Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro 
                245                 250                 255     


Ala Glu Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr 
            260                 265                 270         


Thr Thr Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr 
        275                 280                 285             


Gln Pro Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met 
    290                 295                 300                 


Gly Tyr Met Pro Ser Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr 
305                 310                 315                 320 


Ala Ser Leu Thr Ser Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Ala 
                325                 330                 335     


Cys Thr His Ser Glu Ser Ser Glu Gly Leu Gly Gln Val Asn His Thr 
            340                 345                 350         


Met Glu Val Ser Cys 
        355         


<210>  346
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Pro Glu Cys Trp Asp Gly Glu His Asp Ile Glu Thr Pro Tyr Gly 
1               5                   10                  15      


Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg Pro Ala 
            20                  25                  30          


Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys Phe Asn 
        35                  40                  45              


Thr Phe Phe Asn Phe Glu Asp Met Gln Glu Ile Thr Lys His Phe Val 
    50                  55                  60                  


Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser Gln Phe 
65                  70                  75                  80  


Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Ala Met Leu 
                85                  90                  95      


Pro Ser Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly Ile Gly 
            100                 105                 110         


Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile Phe Pro 
        115                 120                 125             


Asp Leu Val Glu Gly Leu Val Leu Val Asn Ile Asp Pro Asn Gly Lys 
    130                 135                 140                 


Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr Ser Thr 
145                 150                 155                 160 


Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu Leu Val 
                165                 170                 175     


Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Gly Asn Val 
            180                 185                 190         


Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn Ser Arg 
        195                 200                 205             


Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala Lys Thr 
    210                 215                 220                 


Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro Ala Glu 
225                 230                 235                 240 


Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr Thr Thr 
                245                 250                 255     


Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr Gln Pro 
            260                 265                 270         


Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr 
        275                 280                 285             


Ile Ala Tyr Leu Lys Asp Arg Arg Leu Ser Gly Gly Ala Val Pro Ser 
    290                 295                 300                 


Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr Ala Ser Leu Thr Ser 
305                 310                 315                 320 


Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Ala Cys Thr His Ser Glu 
                325                 330                 335     


Ser Ser Glu Gly Leu Gly Gln Val Asn His Thr Met Glu Val Ser Cys 
            340                 345                 350         


<210>  347
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Pro Glu Cys Trp Asp Gly Glu His Asp Ile Glu Thr Pro Tyr Gly 
1               5                   10                  15      


Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg Pro Ala 
            20                  25                  30          


Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys Phe Asn 
        35                  40                  45              


Thr Phe Phe Asn Phe Glu Asp Met Gln Glu Ile Thr Lys His Phe Val 
    50                  55                  60                  


Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser Gln Phe 
65                  70                  75                  80  


Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Ala Met Leu 
                85                  90                  95      


Pro Ser Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly Ile Gly 
            100                 105                 110         


Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile Phe Pro 
        115                 120                 125             


Asp Leu Val Glu Gly Leu Val Leu Val Asn Ile Asp Pro Asn Gly Lys 
    130                 135                 140                 


Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr Ser Thr 
145                 150                 155                 160 


Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu Leu Val 
                165                 170                 175     


Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Gly Asn Val 
            180                 185                 190         


Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn Ser Arg 
        195                 200                 205             


Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala Lys Thr 
    210                 215                 220                 


Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro Ala Glu 
225                 230                 235                 240 


Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr Thr Thr 
                245                 250                 255     


Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr Gln Pro 
            260                 265                 270         


Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr 
        275                 280                 285             


Met Pro Ser Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr Ala Ser 
    290                 295                 300                 


Leu Thr Ser Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Ala Cys Thr 
305                 310                 315                 320 


His Ser Glu Ser Ser Glu Gly Leu Gly Gln Val Asn His Thr Met Glu 
                325                 330                 335     


Val Ser Cys 
            


<210>  348
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Ala Gly Leu Gln Glu Leu Arg Phe Pro Glu Glu Lys Pro Leu Leu 
1               5                   10                  15      


Arg Gly Gln Asp Ala Thr Glu Leu Glu Ser Ser Asp Ala Phe Leu Leu 
            20                  25                  30          


Ala Ala Asp Thr Asp Trp Lys Glu His Asp Ile Glu Thr Pro Tyr Gly 
        35                  40                  45              


Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg Pro Ala 
    50                  55                  60                  


Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Asn Phe Glu Asp Met Gln Glu Ile Thr Lys His Phe Val 
                85                  90                  95      


Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser Gln Phe 
            100                 105                 110         


Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Ala Met Leu 
        115                 120                 125             


Pro Ser Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly Ile Gly 
    130                 135                 140                 


Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile Phe Pro 
145                 150                 155                 160 


Asp Leu Val Glu Gly Leu Val Leu Val Asn Ile Asp Pro Asn Gly Lys 
                165                 170                 175     


Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr Ser Thr 
            180                 185                 190         


Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu Leu Val 
        195                 200                 205             


Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Gly Asn Val 
    210                 215                 220                 


Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn Ser Arg 
225                 230                 235                 240 


Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala Lys Thr 
                245                 250                 255     


Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro Ala Glu 
            260                 265                 270         


Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr Thr Thr 
        275                 280                 285             


Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr Gln Pro 
    290                 295                 300                 


Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr 
305                 310                 315                 320 


Met Pro Ser Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr Ala Ser 
                325                 330                 335     


Leu Thr Ser Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Ala Cys Thr 
            340                 345                 350         


His Ser Glu Ser Ser Glu Gly Leu Gly Gln Val Asn His Thr Met Glu 
        355                 360                 365             


Val Ser Cys 
    370     


<210>  349
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  349

Met Ala Gly Leu Gln Glu Leu Arg Phe Pro Glu Glu Lys Pro Leu Leu 
1               5                   10                  15      


Arg Gly Gln Asp Ala Thr Glu Leu Glu Ser Ser Asp Ala Phe Leu Leu 
            20                  25                  30          


Ala Ala Asp Thr Asp Trp Lys Glu His Asp Ile Glu Thr Pro Tyr Gly 
        35                  40                  45              


Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg Pro Ala 
    50                  55                  60                  


Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys Phe Asn 
65                  70                  75                  80  


Thr Phe Phe Asn Phe Glu Asp Met Gln Glu Ile Thr Lys His Phe Val 
                85                  90                  95      


Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser Gln Phe 
            100                 105                 110         


Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Ala Met Leu 
        115                 120                 125             


Pro Ser Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly Ile Gly 
    130                 135                 140                 


Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile Phe Pro 
145                 150                 155                 160 


Asp Leu Val Glu Gly Leu Val Leu Val Asn Ile Asp Pro Asn Gly Lys 
                165                 170                 175     


Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr Ser Thr 
            180                 185                 190         


Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu Leu Val 
        195                 200                 205             


Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Gly Asn Val 
    210                 215                 220                 


Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn Ser Arg 
225                 230                 235                 240 


Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala Lys Thr 
                245                 250                 255     


Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro Ala Glu 
            260                 265                 270         


Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr Thr Thr 
        275                 280                 285             


Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr Gln Pro 
    290                 295                 300                 


Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr 
305                 310                 315                 320 


Met Pro Ser Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr Ala Ser 
                325                 330                 335     


Leu Thr Ser Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Ala Cys Thr 
            340                 345                 350         


His Ser Glu Ser Ser Glu Gly Leu Gly Gln Val Asn His Thr Met Glu 
        355                 360                 365             


Val Ser Cys 
    370     


<210>  350
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Ala Leu Pro Arg Cys Thr Trp Pro Asn Tyr Val Trp Arg Ala Val 
1               5                   10                  15      


Met Ala Cys Leu Val His Arg Gly Leu Gly Ala Pro Leu Thr Leu Cys 
            20                  25                  30          


Met Leu Gly Cys Leu Leu Gln Ala Gly His Val Leu Ser Gln Lys Leu 
        35                  40                  45              


Asp Asp Val Asp Pro Leu Val Ala Thr Asn Phe Gly Lys Ile Arg Gly 
    50                  55                  60                  


Ile Lys Lys Glu Leu Asn Asn Glu Ile Leu Gly Pro Val Ile Gln Phe 
65                  70                  75                  80  


Leu Gly Val Pro Tyr Ala Ala Pro Pro Thr Gly Glu Arg Arg Phe Gln 
                85                  90                  95      


Pro Pro Glu Pro Pro Ser Pro Trp Ser Asp Ile Arg Asn Ala Thr Gln 
            100                 105                 110         


Phe Ala Pro Val Cys Pro Gln Asn Ile Ile Asp Gly Arg Leu Pro Glu 
        115                 120                 125             


Val Met Leu Pro Val Trp Phe Thr Asn Asn Leu Asp Val Val Ser Ser 
    130                 135                 140                 


Tyr Val Gln Asp Gln Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Val 
145                 150                 155                 160 


Pro Thr Glu Asp Asp Ile Arg Asp Ser Gly Gly Pro Lys Pro Val Met 
                165                 170                 175     


Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn Leu Tyr 
            180                 185                 190         


Asp Gly Ser Val Leu Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Val 
        195                 200                 205             


Asn Tyr Arg Leu Gly Val Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala 
    210                 215                 220                 


Ala Lys Gly Asn Tyr Gly Leu Leu Asp Leu Ile Gln Ala Leu Arg Trp 
225                 230                 235                 240 


Thr Ser Glu Asn Ile Gly Phe Phe Gly Gly Asp Pro Leu Arg Ile Thr 
                245                 250                 255     


Val Phe Gly Ser Gly Ala Gly Gly Ser Cys Val Asn Leu Leu Thr Leu 
            260                 265                 270         


Ser His Tyr Ser Glu Gly Asn Arg Trp Ser Asn Ser Thr Lys Gly Leu 
        275                 280                 285             


Phe Gln Arg Ala Ile Ala Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
    290                 295                 300                 


Val Ser Phe Gln Pro Ala Lys Tyr Ala Arg Met Leu Ala Thr Lys Val 
305                 310                 315                 320 


Gly Cys Asn Val Ser Asp Thr Val Glu Leu Val Glu Cys Leu Gln Lys 
                325                 330                 335     


Lys Pro Tyr Lys Glu Leu Val Asp Gln Asp Ile Gln Pro Ala Arg Tyr 
            340                 345                 350         


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
        355                 360                 365             


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
    370                 375                 380                 


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Asn Ile Val 
385                 390                 395                 400 


Asp Ser Asp Asp Gly Ile Ser Ala Ser Asp Phe Asp Phe Ala Val Ser 
                405                 410                 415     


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Val Leu 
            420                 425                 430         


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg His Asn 
        435                 440                 445             


Pro Glu Thr Arg Arg Lys Thr Leu Leu Ala Leu Phe Thr Asp His Gln 
    450                 455                 460                 


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ser Asn Phe Gly 
465                 470                 475                 480 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Thr Asp Gln 
                485                 490                 495     


Val Pro Ala Trp Ala Asp Ala Ala His Gly Asp Glu Val Pro Tyr Val 
            500                 505                 510         


Leu Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Pro Cys Asn Phe 
        515                 520                 525             


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
    530                 535                 540                 


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
545                 550                 555                 560 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Thr 
                565                 570                 575     


Arg Tyr Ser Gln Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
            580                 585                 590         


Arg Val Lys Glu His Tyr Arg Ala Asn Lys Val Asn Leu Trp Leu Glu 
        595                 600                 605             


Leu Val Pro His Leu His Asn Leu Asn Asp Ile Ser Gln Tyr Thr Ser 
    610                 615                 620                 


Thr Thr Thr Lys Val Pro Ser Thr Asp Ile Thr Phe Arg Pro Thr Arg 
625                 630                 635                 640 


Lys Asn Ser Val Pro Val Thr Ser Ala Phe Pro Thr Ala Lys Gln Asp 
                645                 650                 655     


Asp Pro Lys Gln Gln Pro Ser Pro Phe Ser Val Asp Gln Arg Asp Tyr 
            660                 665                 670         


Ser Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe 
        675                 680                 685             


Leu Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg 
    690                 695                 700                 


Arg His Asp Val His Arg Arg Cys Ser Pro Gln Arg Thr Thr Thr Asn 
705                 710                 715                 720 


Asp Leu Thr His Ala Gln Glu Glu Glu Ile Met Ser Leu Gln Met Lys 
                725                 730                 735     


His Thr Asp Leu Asp His Glu Cys Glu Ser Ile His Pro His Glu Val 
            740                 745                 750         


Val Leu Arg Thr Ala Cys Pro Pro Asp Tyr Thr Leu Ala Met Arg Arg 
        755                 760                 765             


Ser Pro Asp Asp Val Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile 
    770                 775                 780                 


Pro Asn Thr Ile Pro Gly Ile Gln Pro Leu His Thr Phe Asn Thr Phe 
785                 790                 795                 800 


Thr Gly Gly Gln Asn Asn Thr Leu Pro His Pro His Pro His Pro His 
                805                 810                 815     


Ser His Ser Thr Thr Arg Val 
            820             


<210>  351
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  351

Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro 
1               5                   10                  15      


Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala 
            20                  25                  30          


Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe 
        35                  40                  45              


Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly 
    50                  55                  60                  


Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly 
65                  70                  75                  80  


Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile 
                85                  90                  95      


Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr 
            100                 105                 110         


Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp 
        115                 120                 125             


Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu 
    130                 135                 140                 


Asn Val Tyr Val Pro Thr Glu Asp Asp Ile Arg Asp Ser Gly Ala Lys 
145                 150                 155                 160 


Pro Val Met Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly 
                165                 170                 175     


Asn Met Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly Asn Val Ile Val 
            180                 185                 190         


Ile Thr Leu Asn Tyr Arg Val Gly Val Leu Gly Phe Leu Ser Thr Gly 
        195                 200                 205             


Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala 
    210                 215                 220                 


Leu Arg Trp Val Ser Glu Asn Ile Ala Phe Phe Gly Gly Asp Pro Arg 
225                 230                 235                 240 


Arg Ile Thr Val Phe Gly Ser Gly Ile Gly Ala Ser Cys Val Ser Leu 
                245                 250                 255     


Leu Thr Leu Ser His His Ser Glu Gly Leu Phe Gln Arg Ala Ile Ile 
            260                 265                 270         


Gln Ser Gly Ser Ala Leu Ser Ser Trp Ala Val Asn Tyr Gln Pro Val 
        275                 280                 285             


Lys Tyr Thr Ser Leu Leu Ala Asp Lys Val Gly Cys Asn Val Leu Asp 
    290                 295                 300                 


Thr Val Asp Met Val Asp Cys Leu Arg Gln Lys Ser Ala Lys Glu Leu 
305                 310                 315                 320 


Val Glu Gln Asp Ile Gln Pro Ala Arg Tyr His Val Ala Phe Gly Pro 
                325                 330                 335     


Val Ile Asp Gly Asp Val Ile Pro Asp Asp Pro Glu Ile Leu Met Glu 
            340                 345                 350         


Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly Val Asn Gln Gly 
        355                 360                 365             


Glu Gly Leu Lys Phe Val Glu Gly Val Val Asp Pro Glu Asp Gly Val 
    370                 375                 380                 


Ser Gly Thr Asp Phe Asp Tyr Ser Val Ser Asn Phe Val Asp Asn Leu 
385                 390                 395                 400 


Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu Arg Glu Thr Ile Lys Phe 
                405                 410                 415     


Met Tyr Thr Asp Trp Ala Asp Arg Asp Asn Pro Glu Thr Arg Arg Lys 
            420                 425                 430         


Thr Leu Val Ala Leu Phe Thr Asp His Gln Trp Val Glu Pro Ser Val 
        435                 440                 445             


Val Thr Ala Asp Leu His Ala Arg Tyr Gly Ser Pro Thr Tyr Phe Tyr 
    450                 455                 460                 


Ala Phe Tyr His His Cys Gln Ser Leu Met Lys Pro Ala Trp Ser Asp 
465                 470                 475                 480 


Ala Ala His Gly Asp Glu Val Pro Tyr Val Phe Gly Val Pro Met Val 
                485                 490                 495     


Gly Pro Thr Asp Leu Phe Pro Cys Asn Phe Ser Lys Asn Asp Val Met 
            500                 505                 510         


Leu Ser Ala Val Val Met Thr Tyr Trp Thr Asn Phe Ala Lys Thr Gly 
        515                 520                 525             


Asp Pro Asn Lys Pro Val Pro Gln Asp Thr Lys Phe Ile His Thr Lys 
    530                 535                 540                 


Ala Asn Arg Phe Glu Glu Val Ala Trp Ser Lys Tyr Asn Pro Arg Asp 
545                 550                 555                 560 


Gln Leu Tyr Leu His Ile Gly Leu Lys Pro Arg Val Arg Asp His Tyr 
                565                 570                 575     


Arg Ala Thr Lys Val Ala Phe Trp Lys His Leu Val Pro His Leu Tyr 
            580                 585                 590         


Asn Leu His Asp Met Phe His Tyr Thr Ser Thr Thr Thr Lys Val Pro 
        595                 600                 605             


Pro Pro Asp Thr Thr His Ser Ser His Ile Thr Arg Arg Pro Asn Gly 
    610                 615                 620                 


Lys Thr Trp Ser Thr Lys Arg Pro Ala Ile Ser Pro Ala Tyr Ser Asn 
625                 630                 635                 640 


Glu Asn Ala Gln Gly Ser Trp Asn Gly Asp Gln Asp Ala Gly Pro Leu 
                645                 650                 655     


Leu Val Glu Asn Pro Arg Asp Tyr Ser Thr Glu Leu Ser Val Thr Ile 
            660                 665                 670         


Ala Val Gly Ala Ser Leu Leu Phe Leu Asn Val Leu Ala Phe Ala Ala 
        675                 680                 685             


Leu Tyr Tyr Arg Lys Asp Lys Arg Arg Gln Glu Pro Leu Arg Gln Pro 
    690                 695                 700                 


Ser Pro Gln Arg Gly Ala Gly Ala Pro Glu Leu Gly Ala Ala Pro Glu 
705                 710                 715                 720 


Glu Glu Leu Ala Ala Leu Gln Leu Gly Pro Thr His His Glu Cys Glu 
                725                 730                 735     


Ala Gly Pro Pro His Asp Thr Leu Arg Leu Thr Ala Leu Pro Asp Tyr 
            740                 745                 750         


Thr Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro Leu Met Thr Pro 
        755                 760                 765             


Asn Thr Ile Thr Met Ile Pro Asn Ser Leu Val Gly Leu Gln Thr Leu 
    770                 775                 780                 


His Pro Tyr Asn Thr Phe Ala Ala Gly Phe Asn Ser Thr Gly Leu Pro 
785                 790                 795                 800 


His Ser His Ser Thr Thr Arg Val 
                805             


<210>  352
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp Ile Val Ala Thr Tyr 
1               5                   10                  15      


Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu Asn Val Tyr Val Pro 
            20                  25                  30          


Thr Glu Asp Gly Ser Gly Ala Lys Lys Gln Gly Glu Asp Leu Ala Asp 
        35                  40                  45              


Asn Asp Gly Asp Glu Asp Glu Asp Ile Arg Asp Ser Gly Ala Lys Pro 
    50                  55                  60                  


Val Met Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn 
65                  70                  75                  80  


Met Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly Asn Val Ile Val Ile 
                85                  90                  95      


Thr Leu Asn Tyr Arg Val Gly Val Leu Gly Phe Leu Ser Thr Gly Asp 
            100                 105                 110         


Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala Leu 
        115                 120                 125             


Arg Trp Val Ser Glu Asn Ile Ala Phe Phe Gly Gly Asp Pro Arg Arg 
    130                 135                 140                 


Ile Thr Val Phe Gly Ser Gly Ile Gly Ala Ser Cys Val Ser Leu Leu 
145                 150                 155                 160 


Thr Leu Ser His His Ser Glu Gly Leu Phe Gln Arg Ala Ile Ile Gln 
                165                 170                 175     


Ser Gly Ser Ala Leu Ser Ser Trp Ala Val Asn Tyr Gln Pro Val Lys 
            180                 185                 190         


Tyr Thr Ser Leu Leu Ala Asp Lys Val Gly Cys Asn Val Leu Asp Thr 
        195                 200                 205             


Val Asp Met Val Asp Cys Leu Arg Gln Lys Ser Ala Lys Glu Leu Val 
    210                 215                 220                 


Glu Gln Asp Ile Gln Pro Ala Arg Tyr His Val Ala Phe Gly Pro Val 
225                 230                 235                 240 


Ile Asp Gly Asp Val Ile Pro Asp Asp Pro Glu Ile Leu Met Glu Gln 
                245                 250                 255     


Gly Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly Val Asn Gln Gly Glu 
            260                 265                 270         


Gly Leu Lys Phe Val Glu Gly Val Val Asp Pro Glu Asp Gly Val Ser 
        275                 280                 285             


Gly Thr Asp Phe Asp Tyr Ser Val Ser Asn Phe Val Asp Asn Leu Tyr 
    290                 295                 300                 


Gly Tyr Pro Glu Gly Lys Asp Thr Leu Arg Glu Thr Ile Lys Phe Met 
305                 310                 315                 320 


Tyr Thr Asp Trp Ala Asp Arg Asp Asn Pro Glu Thr Arg Arg Lys Thr 
                325                 330                 335     


Leu Val Ala Leu Phe Thr Asp His Gln Trp Val Glu Pro Ser Val Val 
            340                 345                 350         


Thr Ala Asp Leu His Ala Arg Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala 
        355                 360                 365             


Phe Tyr His His Cys Gln Ser Leu Met Lys Pro Ala Trp Ser Asp Ala 
    370                 375                 380                 


Ala His Gly Asp Glu Val Pro Tyr Val Phe Gly Val Pro Met Val Gly 
385                 390                 395                 400 


Pro Thr Asp Leu Phe Pro Cys Asn Phe Ser Lys Asn Asp Val Met Leu 
                405                 410                 415     


Ser Ala Val Val Met Thr Tyr Trp Thr Asn Phe Ala Lys Thr Gly Asp 
            420                 425                 430         


Pro Asn Lys Pro Val Pro Gln Asp Thr Lys Phe Ile His Thr Lys Ala 
        435                 440                 445             


Asn Arg Phe Glu Glu Val Ala Trp Ser Lys Tyr Asn Pro Arg Asp Gln 
    450                 455                 460                 


Leu Tyr Leu His Ile Gly Leu Lys Pro Arg Val Arg Asp His Tyr Arg 
465                 470                 475                 480 


Ala Thr Lys Val Ala Phe Trp Lys His Leu Val Pro His Leu Tyr Asn 
                485                 490                 495     


Leu His Asp Met Phe His Tyr Thr Ser Thr Thr Thr Lys Val Pro Pro 
            500                 505                 510         


Pro Asp Thr Thr His Ser Ser His Ile Thr Arg Arg Pro Asn Gly Lys 
        515                 520                 525             


Thr Trp Ser Thr Lys Arg Pro Ala Ile Ser Pro Ala Tyr Ser Asn Glu 
    530                 535                 540                 


Asn Ala Gln Gly Ser Trp Asn Gly Asp Gln Asp Ala Gly Pro Leu Leu 
545                 550                 555                 560 


Val Glu Asn Pro Arg Asp Tyr Ser Thr Glu Leu Ser Val Thr Ile Ala 
                565                 570                 575     


Val Gly Ala Ser Leu Leu Phe Leu Asn Val Leu Ala Phe Ala Ala Leu 
            580                 585                 590         


Tyr Tyr Arg Lys Asp Lys Arg Arg Gln Glu Pro Leu Arg Gln Pro Ser 
        595                 600                 605             


Pro Gln Arg Gly Ala Gly Ala Pro Glu Leu Gly Ala Ala Pro Glu Glu 
    610                 615                 620                 


Glu Leu Ala Ala Leu Gln Leu Gly Pro Thr His His Glu Cys Glu Ala 
625                 630                 635                 640 


Gly Pro Pro His Asp Thr Leu Arg Leu Thr Ala Leu Pro Asp Tyr Thr 
                645                 650                 655     


Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro Leu Met Thr Pro Asn 
            660                 665                 670         


Thr Ile Thr Met Ile Pro Asn Ser Leu Val Gly Leu Gln Thr Leu His 
        675                 680                 685             


Pro Tyr Asn Thr Phe Ala Ala Gly Phe Asn Ser Thr Gly Leu Pro His 
    690                 695                 700                 


Ser His Ser Thr Thr Arg Val 
705                 710     


<210>  353
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  353

Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro 
1               5                   10                  15      


Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala 
            20                  25                  30          


Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe 
        35                  40                  45              


Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly 
    50                  55                  60                  


Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly 
65                  70                  75                  80  


Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile 
                85                  90                  95      


Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr 
            100                 105                 110         


Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp 
        115                 120                 125             


Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu 
    130                 135                 140                 


Asn Val Tyr Val Pro Thr Glu Asp Gly Ser Gly Ala Lys Lys Gln Gly 
145                 150                 155                 160 


Glu Asp Leu Ala Asp Asn Asp Gly Asp Glu Asp Glu Asp Ile Arg Asp 
                165                 170                 175     


Ser Gly Ala Lys Pro Val Met Val Tyr Ile His Gly Gly Ser Tyr Met 
            180                 185                 190         


Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly 
        195                 200                 205             


Asn Val Ile Val Ile Thr Leu Asn Tyr Arg Val Gly Val Leu Gly Phe 
    210                 215                 220                 


Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp 
225                 230                 235                 240 


Gln Ile Gln Ala Leu Arg Trp Val Ser Glu Asn Ile Ala Phe Phe Gly 
                245                 250                 255     


Gly Asp Pro Arg Arg Ile Thr Val Phe Gly Ser Gly Ile Gly Ala Ser 
            260                 265                 270         


Cys Val Ser Leu Leu Thr Leu Ser His His Ser Glu Gly Leu Phe Gln 
        275                 280                 285             


Arg Ala Ile Ile Gln Ser Gly Ser Ala Leu Ser Ser Trp Ala Val Asn 
    290                 295                 300                 


Tyr Gln Pro Val Lys Tyr Thr Ser Leu Leu Ala Asp Lys Val Gly Cys 
305                 310                 315                 320 


Asn Val Leu Asp Thr Val Asp Met Val Asp Cys Leu Arg Gln Lys Ser 
                325                 330                 335     


Ala Lys Glu Leu Val Glu Gln Asp Ile Gln Pro Ala Arg Tyr His Val 
            340                 345                 350         


Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp Pro Glu 
        355                 360                 365             


Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly 
    370                 375                 380                 


Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Gly Val Val Asp Pro 
385                 390                 395                 400 


Glu Asp Gly Val Ser Gly Thr Asp Phe Asp Tyr Ser Val Ser Asn Phe 
                405                 410                 415     


Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu Arg Glu 
            420                 425                 430         


Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg Asp Asn Pro Glu 
        435                 440                 445             


Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln Trp Val 
    450                 455                 460                 


Glu Pro Ser Val Val Thr Ala Asp Leu His Ala Arg Tyr Gly Ser Pro 
465                 470                 475                 480 


Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Leu Met Lys Pro 
                485                 490                 495     


Ala Trp Ser Asp Ala Ala His Gly Asp Glu Val Pro Tyr Val Phe Gly 
            500                 505                 510         


Val Pro Met Val Gly Pro Thr Asp Leu Phe Pro Cys Asn Phe Ser Lys 
        515                 520                 525             


Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr Asn Phe 
    530                 535                 540                 


Ala Lys Thr Gly Asp Pro Asn Lys Pro Val Pro Gln Asp Thr Lys Phe 
545                 550                 555                 560 


Ile His Thr Lys Ala Asn Arg Phe Glu Glu Val Ala Trp Ser Lys Tyr 
                565                 570                 575     


Asn Pro Arg Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro Arg Val 
            580                 585                 590         


Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Lys His Leu Val 
        595                 600                 605             


Pro His Leu Tyr Asn Leu His Asp Met Phe His Tyr Thr Ser Thr Thr 
    610                 615                 620                 


Thr Lys Val Pro Pro Pro Asp Thr Thr His Ser Ser His Ile Thr Arg 
625                 630                 635                 640 


Arg Pro Asn Gly Lys Thr Trp Ser Thr Lys Arg Pro Ala Ile Ser Pro 
                645                 650                 655     


Ala Tyr Ser Asn Glu Asn Ala Gln Gly Ser Trp Asn Gly Asp Gln Asp 
            660                 665                 670         


Ala Gly Pro Leu Leu Val Glu Asn Pro Arg Asp Tyr Ser Thr Glu Leu 
        675                 680                 685             


Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu Asn Val Leu 
    690                 695                 700                 


Ala Phe Ala Ala Leu Tyr Tyr Arg Lys Asp Lys Arg Arg Gln Glu Pro 
705                 710                 715                 720 


Leu Arg Gln Pro Ser Pro Gln Arg Gly Ala Gly Ala Pro Glu Leu Gly 
                725                 730                 735     


Ala Ala Pro Glu Glu Glu Leu Ala Ala Leu Gln Leu Gly Pro Thr His 
            740                 745                 750         


His Glu Cys Glu Ala Gly Pro Pro His Asp Thr Leu Arg Leu Thr Ala 
        755                 760                 765             


Leu Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro 
    770                 775                 780                 


Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn Ser Leu Val Gly 
785                 790                 795                 800 


Leu Gln Thr Leu His Pro Tyr Asn Thr Phe Ala Ala Gly Phe Asn Ser 
                805                 810                 815     


Thr Gly Leu Pro His Ser His Ser Thr Thr Arg Val 
            820                 825             


<210>  354
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro 
1               5                   10                  15      


Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala 
            20                  25                  30          


Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe 
        35                  40                  45              


Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly 
    50                  55                  60                  


Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly 
65                  70                  75                  80  


Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile 
                85                  90                  95      


Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr 
            100                 105                 110         


Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp 
        115                 120                 125             


Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu 
    130                 135                 140                 


Asn Val Tyr Val Pro Thr Glu Asp Val Lys Arg Ile Ser Lys Glu Cys 
145                 150                 155                 160 


Ala Arg Lys Pro Asn Lys Lys Ile Cys Arg Lys Gly Gly Ser Gly Ala 
                165                 170                 175     


Lys Lys Gln Gly Glu Asp Leu Ala Asp Asn Asp Gly Asp Glu Asp Glu 
            180                 185                 190         


Asp Ile Arg Asp Ser Gly Ala Lys Pro Val Met Val Tyr Ile His Gly 
        195                 200                 205             


Gly Ser Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu 
    210                 215                 220                 


Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Leu Asn Tyr Arg Val Gly 
225                 230                 235                 240 


Val Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr 
                245                 250                 255     


Gly Leu Leu Asp Gln Ile Gln Ala Leu Arg Trp Val Ser Glu Asn Ile 
            260                 265                 270         


Ala Phe Phe Gly Gly Asp Pro Arg Arg Ile Thr Val Phe Gly Ser Gly 
        275                 280                 285             


Ile Gly Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His His Ser Glu 
    290                 295                 300                 


Gly Leu Phe Gln Arg Ala Ile Ile Gln Ser Gly Ser Ala Leu Ser Ser 
305                 310                 315                 320 


Trp Ala Val Asn Tyr Gln Pro Val Lys Tyr Thr Ser Leu Leu Ala Asp 
                325                 330                 335     


Lys Val Gly Cys Asn Val Leu Asp Thr Val Asp Met Val Asp Cys Leu 
            340                 345                 350         


Arg Gln Lys Ser Ala Lys Glu Leu Val Glu Gln Asp Ile Gln Pro Ala 
        355                 360                 365             


Arg Tyr His Val Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro 
    370                 375                 380                 


Asp Asp Pro Glu Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp 
385                 390                 395                 400 


Ile Met Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Gly 
                405                 410                 415     


Val Val Asp Pro Glu Asp Gly Val Ser Gly Thr Asp Phe Asp Tyr Ser 
            420                 425                 430         


Val Ser Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp 
        435                 440                 445             


Thr Leu Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg 
    450                 455                 460                 


Asp Asn Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp 
465                 470                 475                 480 


His Gln Trp Val Glu Pro Ser Val Val Thr Ala Asp Leu His Ala Arg 
                485                 490                 495     


Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser 
            500                 505                 510         


Leu Met Lys Pro Ala Trp Ser Asp Ala Ala His Gly Asp Glu Val Pro 
        515                 520                 525             


Tyr Val Phe Gly Val Pro Met Val Gly Pro Thr Asp Leu Phe Pro Cys 
    530                 535                 540                 


Asn Phe Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr 
545                 550                 555                 560 


Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn Lys Pro Val Pro Gln 
                565                 570                 575     


Asp Thr Lys Phe Ile His Thr Lys Ala Asn Arg Phe Glu Glu Val Ala 
            580                 585                 590         


Trp Ser Lys Tyr Asn Pro Arg Asp Gln Leu Tyr Leu His Ile Gly Leu 
        595                 600                 605             


Lys Pro Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp 
    610                 615                 620                 


Lys His Leu Val Pro His Leu Tyr Asn Leu His Asp Met Phe His Tyr 
625                 630                 635                 640 


Thr Ser Thr Thr Thr Lys Val Pro Pro Pro Asp Thr Thr His Ser Ser 
                645                 650                 655     


His Ile Thr Arg Arg Pro Asn Gly Lys Thr Trp Ser Thr Lys Arg Pro 
            660                 665                 670         


Ala Ile Ser Pro Ala Tyr Ser Asn Glu Asn Ala Gln Gly Ser Trp Asn 
        675                 680                 685             


Gly Asp Gln Asp Ala Gly Pro Leu Leu Val Glu Asn Pro Arg Asp Tyr 
    690                 695                 700                 


Ser Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe 
705                 710                 715                 720 


Leu Asn Val Leu Ala Phe Ala Ala Leu Tyr Tyr Arg Lys Asp Lys Arg 
                725                 730                 735     


Arg Gln Glu Pro Leu Arg Gln Pro Ser Pro Gln Arg Gly Ala Gly Ala 
            740                 745                 750         


Pro Glu Leu Gly Ala Ala Pro Glu Glu Glu Leu Ala Ala Leu Gln Leu 
        755                 760                 765             


Gly Pro Thr His His Glu Cys Glu Ala Gly Pro Pro His Asp Thr Leu 
    770                 775                 780                 


Arg Leu Thr Ala Leu Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
785                 790                 795                 800 


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
                805                 810                 815     


Ser Leu Val Gly Leu Gln Thr Leu His Pro Tyr Asn Thr Phe Ala Ala 
            820                 825                 830         


Gly Phe Asn Ser Thr Gly Leu Pro His Ser His Ser Thr Thr Arg Val 
        835                 840                 845             


<210>  355
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     


<210>  356
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     


<210>  357
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  357

Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     


<210>  358
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     


<210>  359
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  359

Met Ala Val Ser Trp Arg Ser Trp Leu Ala Asn Glu Gly Val Lys His 
1               5                   10                  15      


Leu Cys Leu Phe Ile Trp Leu Ser Met Asn Val Leu Leu Phe Trp Lys 
            20                  25                  30          


Thr Phe Leu Leu Tyr Asn Gln Gly Pro Glu Tyr His Tyr Leu His Gln 
        35                  40                  45              


Met Leu Gly Leu Gly Leu Cys Leu Ser Arg Ala Ser Ala Ser Val Leu 
    50                  55                  60                  


Asn Leu Asn Cys Ser Leu Ile Leu Leu Pro Met Cys Arg Thr Leu Leu 
65                  70                  75                  80  


Ala Tyr Leu Arg Gly Ser Gln Lys Val Pro Ser Arg Arg Thr Arg Arg 
                85                  90                  95      


Leu Leu Asp Lys Ser Arg Thr Phe His Ile Thr Cys Gly Val Thr Ile 
            100                 105                 110         


Cys Ile Phe Ser Gly Val His Val Ala Ala His Leu Val Asn Ala Leu 
        115                 120                 125             


Asn Phe Ser Val Asn Tyr Ser Glu Asp Phe Val Glu Leu Asn Ala Ala 
    130                 135                 140                 


Arg Tyr Arg Asp Glu Asp Pro Arg Lys Leu Leu Phe Thr Thr Val Pro 
145                 150                 155                 160 


Gly Leu Thr Gly Val Cys Met Val Val Val Leu Phe Leu Met Ile Thr 
                165                 170                 175     


Ala Ser Thr Tyr Ala Ile Arg Val Ser Asn Tyr Asp Ile Phe Trp Tyr 
            180                 185                 190         


Thr His Asn Leu Phe Phe Val Phe Tyr Met Leu Leu Thr Leu His Val 
        195                 200                 205             


Ser Gly Gly Leu Leu Lys Tyr Gln Thr Asn Leu Asp Thr His Pro Pro 
    210                 215                 220                 


Gly Cys Ile Ser Leu Asn Arg Thr Ser Ser Gln Asn Ile Ser Leu Pro 
225                 230                 235                 240 


Glu Tyr Phe Ser Glu His Phe His Glu Pro Phe Pro Glu Gly Phe Ser 
                245                 250                 255     


Lys Pro Ala Glu Phe Thr Gln His Lys Phe Val Lys Ile Cys Met Glu 
            260                 265                 270         


Glu Pro Arg Phe Gln Ala Asn Phe Pro Gln Thr Trp Leu Trp Ile Ser 
        275                 280                 285             


Gly Pro Leu Cys Leu Tyr Cys Ala Glu Arg Leu Tyr Arg Tyr Ile Arg 
    290                 295                 300                 


Ser Asn Lys Pro Val Thr Ile Ile Ser Val Ile Ser His Pro Ser Asp 
305                 310                 315                 320 


Val Met Glu Ile Arg Met Val Lys Glu Asn Phe Lys Ala Arg Pro Gly 
                325                 330                 335     


Gln Tyr Ile Thr Leu His Cys Pro Ser Val Ser Ala Leu Glu Asn His 
            340                 345                 350         


Pro Phe Thr Leu Thr Met Cys Pro Thr Glu Thr Lys Ala Thr Phe Gly 
        355                 360                 365             


Val His Leu Lys Ile Val Gly Asp Trp Thr Glu Arg Phe Arg Asp Leu 
    370                 375                 380                 


Leu Leu Pro Pro Ser Ser Gln Asp Ser Glu Ile Leu Pro Phe Ile Gln 
385                 390                 395                 400 


Ser Arg Asn Tyr Pro Lys Asp Asp Trp Lys Pro Tyr Lys Leu Arg Arg 
                405                 410                 415     


Leu Tyr Phe Ile Trp Val Cys Arg Asp Ile Gln Ser Phe Arg Trp Phe 
            420                 425                 430         


Ala Asp Leu Leu Cys Met Leu His Asn Lys Phe Trp Gln Glu Asn Arg 
        435                 440                 445             


Pro Asp Tyr Val Asn Ile Gln Leu Tyr Leu Ser Gln Thr Asp Gly Ile 
    450                 455                 460                 


Gln Lys Ile Ile Gly Glu Lys Tyr His Ala Leu Asn Ser Arg Leu Phe 
465                 470                 475                 480 


Ile Gly Arg Pro Arg Trp Lys Leu Leu Phe Asp Glu Ile Ala Lys Tyr 
                485                 490                 495     


Asn Arg Gly Lys Thr Val Gly Val Phe Cys Cys Gly Pro Asn Ser Leu 
            500                 505                 510         


Ser Lys Thr Leu His Lys Leu Ser Asn Gln Asn Asn Ser Tyr Gly Thr 
        515                 520                 525             


Arg Phe Glu Tyr Asn Lys Glu Ser Phe Ser 
    530                 535             


<210>  360
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Asn Val Leu Leu Phe Trp Lys Thr Phe Leu Leu Tyr Asn Gln Gly 
1               5                   10                  15      


Pro Glu Tyr His Tyr Leu His Gln Met Leu Gly Leu Gly Leu Cys Leu 
            20                  25                  30          


Ser Arg Ala Ser Ala Ser Val Leu Asn Leu Asn Cys Ser Leu Ile Leu 
        35                  40                  45              


Leu Pro Met Cys Arg Thr Leu Leu Ala Tyr Leu Arg Gly Ser Gln Lys 
    50                  55                  60                  


Val Pro Ser Arg Arg Thr Arg Arg Leu Leu Asp Lys Ser Arg Thr Phe 
65                  70                  75                  80  


His Ile Thr Cys Gly Val Thr Ile Cys Ile Phe Ser Gly Val His Val 
                85                  90                  95      


Ala Ala His Leu Val Asn Ala Leu Asn Phe Ser Val Asn Tyr Ser Glu 
            100                 105                 110         


Asp Phe Val Glu Leu Asn Ala Ala Arg Tyr Arg Asp Glu Asp Pro Arg 
        115                 120                 125             


Lys Leu Leu Phe Thr Thr Val Pro Gly Leu Thr Gly Val Cys Met Val 
    130                 135                 140                 


Val Val Leu Phe Leu Met Ile Thr Ala Ser Thr Tyr Ala Ile Arg Val 
145                 150                 155                 160 


Ser Asn Tyr Asp Ile Phe Trp Tyr Thr His Asn Leu Phe Phe Val Phe 
                165                 170                 175     


Tyr Met Leu Leu Thr Leu His Val Ser Gly Gly Leu Leu Lys Tyr Gln 
            180                 185                 190         


Thr Asn Leu Asp Thr His Pro Pro Gly Cys Ile Ser Leu Asn Arg Thr 
        195                 200                 205             


Ser Ser Gln Asn Ile Ser Leu Pro Glu Tyr Phe Ser Glu His Phe His 
    210                 215                 220                 


Glu Pro Phe Pro Glu Gly Phe Ser Lys Pro Ala Glu Phe Thr Gln His 
225                 230                 235                 240 


Lys Phe Val Lys Ile Cys Met Glu Glu Pro Arg Phe Gln Ala Asn Phe 
                245                 250                 255     


Pro Gln Thr Trp Leu Trp Ile Ser Gly Pro Leu Cys Leu Tyr Cys Ala 
            260                 265                 270         


Glu Arg Leu Tyr Arg Tyr Ile Arg Ser Asn Lys Pro Val Thr Ile Ile 
        275                 280                 285             


Ser Val Ile Ser His Pro Ser Asp Val Met Glu Ile Arg Met Val Lys 
    290                 295                 300                 


Glu Asn Phe Lys Ala Arg Pro Gly Gln Tyr Ile Thr Leu His Cys Pro 
305                 310                 315                 320 


Ser Val Ser Ala Leu Glu Asn His Pro Phe Thr Leu Thr Met Cys Pro 
                325                 330                 335     


Thr Glu Thr Lys Ala Thr Phe Gly Val His Leu Lys Ile Val Gly Asp 
            340                 345                 350         


Trp Thr Glu Arg Phe Arg Asp Leu Leu Leu Pro Pro Ser Ser Gln Asp 
        355                 360                 365             


Ser Glu Ile Leu Pro Phe Ile Gln Ser Arg Asn Tyr Pro Lys Leu Tyr 
    370                 375                 380                 


Ile Asp Gly Pro Phe Gly Ser Pro Phe Glu Glu Ser Leu Asn Tyr Glu 
385                 390                 395                 400 


Val Ser Leu Cys Val Ala Gly Gly Ile Gly Val Thr Pro Phe Ala Ser 
                405                 410                 415     


Ile Leu Asn Thr Leu Leu Asp Asp Trp Lys Pro Tyr Lys Leu Arg Arg 
            420                 425                 430         


Leu Tyr Phe Ile Trp Val Cys Arg Asp Ile Gln Ser Phe Arg Trp Phe 
        435                 440                 445             


Ala Asp Leu Leu Cys Met Leu His Asn Lys Phe Trp Gln Glu Asn Arg 
    450                 455                 460                 


Pro Asp Tyr Val Asn Ile Gln Leu Tyr Leu Ser Gln Thr Asp Gly Ile 
465                 470                 475                 480 


Gln Lys Ile Ile Gly Glu Lys Tyr His Ala Leu Asn Ser Arg Leu Phe 
                485                 490                 495     


Ile Gly Arg Pro Arg Trp Lys Leu Leu Phe Asp Glu Ile Ala Lys Tyr 
            500                 505                 510         


Asn Arg Gly Lys Thr Val Gly Val Phe Cys Cys Gly Pro Asn Ser Leu 
        515                 520                 525             


Ser Lys Thr Leu His Lys Leu Ser Asn Gln Asn Asn Ser Tyr Gly Thr 
    530                 535                 540                 


Arg Phe Glu Tyr Asn Lys Glu Ser Phe Ser 
545                 550                 


<210>  361
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  361

Met Cys Arg Thr Leu Leu Ala Tyr Leu Arg Gly Ser Gln Lys Val Pro 
1               5                   10                  15      


Ser Arg Arg Thr Arg Arg Leu Leu Asp Lys Ser Arg Thr Phe His Ile 
            20                  25                  30          


Thr Cys Gly Val Thr Ile Cys Ile Phe Ser Gly Val His Val Ala Ala 
        35                  40                  45              


His Leu Val Asn Ala Leu Asn Phe Ser Val Asn Tyr Ser Glu Asp Phe 
    50                  55                  60                  


Val Glu Leu Asn Ala Ala Arg Tyr Arg Asp Glu Asp Pro Arg Lys Leu 
65                  70                  75                  80  


Leu Phe Thr Thr Val Pro Gly Leu Thr Gly Val Cys Met Val Val Val 
                85                  90                  95      


Leu Phe Leu Met Ile Thr Ala Ser Thr Tyr Ala Ile Arg Val Ser Asn 
            100                 105                 110         


Tyr Asp Ile Phe Trp Tyr Thr His Asn Leu Phe Phe Val Phe Tyr Met 
        115                 120                 125             


Leu Leu Thr Leu His Val Ser Gly Gly Leu Leu Lys Tyr Gln Thr Asn 
    130                 135                 140                 


Leu Asp Thr His Pro Pro Gly Cys Ile Ser Leu Asn Arg Thr Ser Ser 
145                 150                 155                 160 


Gln Asn Ile Ser Leu Pro Glu Tyr Phe Ser Glu His Phe His Glu Pro 
                165                 170                 175     


Phe Pro Glu Gly Phe Ser Lys Pro Ala Glu Phe Thr Gln His Lys Phe 
            180                 185                 190         


Val Lys Ile Cys Met Glu Glu Pro Arg Phe Gln Ala Asn Phe Pro Gln 
        195                 200                 205             


Thr Trp Leu Trp Ile Ser Gly Pro Leu Cys Leu Tyr Cys Ala Glu Arg 
    210                 215                 220                 


Leu Tyr Arg Tyr Ile Arg Ser Asn Lys Pro Val Thr Ile Ile Ser Val 
225                 230                 235                 240 


Ile Ser His Pro Ser Asp Val Met Glu Ile Arg Met Val Lys Glu Asn 
                245                 250                 255     


Phe Lys Ala Arg Pro Gly Gln Tyr Ile Thr Leu His Cys Pro Ser Val 
            260                 265                 270         


Ser Ala Leu Glu Asn His Pro Phe Thr Leu Thr Met Cys Pro Thr Glu 
        275                 280                 285             


Thr Lys Ala Thr Phe Gly Val His Leu Lys Ile Val Gly Asp Trp Thr 
    290                 295                 300                 


Glu Arg Phe Arg Asp Leu Leu Leu Pro Pro Ser Ser Gln Asp Ser Glu 
305                 310                 315                 320 


Ile Leu Pro Phe Ile Gln Ser Arg Asn Tyr Pro Lys Leu Tyr Ile Asp 
                325                 330                 335     


Gly Pro Phe Gly Ser Pro Phe Glu Glu Ser Leu Asn Tyr Glu Val Ser 
            340                 345                 350         


Leu Cys Val Ala Gly Gly Ile Gly Val Thr Pro Phe Ala Ser Ile Leu 
        355                 360                 365             


Asn Thr Leu Leu Asp Asp Trp Lys Pro Tyr Lys Leu Arg Arg Leu Tyr 
    370                 375                 380                 


Phe Ile Trp Val Cys Arg Asp Ile Gln Ser Phe Arg Trp Phe Ala Asp 
385                 390                 395                 400 


Leu Leu Cys Met Leu His Asn Lys Phe Trp Gln Glu Asn Arg Pro Asp 
                405                 410                 415     


Tyr Val Asn Ile Gln Leu Tyr Leu Ser Gln Thr Asp Gly Ile Gln Lys 
            420                 425                 430         


Ile Ile Gly Glu Lys Tyr His Ala Leu Asn Ser Arg Leu Phe Ile Gly 
        435                 440                 445             


Arg Pro Arg Trp Lys Leu Leu Phe Asp Glu Ile Ala Lys Tyr Asn Arg 
    450                 455                 460                 


Gly Lys Thr Val Gly Val Phe Cys Cys Gly Pro Asn Ser Leu Ser Lys 
465                 470                 475                 480 


Thr Leu His Lys Leu Ser Asn Gln Asn Asn Ser Tyr Gly Thr Arg Phe 
                485                 490                 495     


Glu Tyr Asn Lys Glu Ser Phe Ser 
            500                 


<210>  362
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  362

Met Gly Glu Met Trp Arg Lys Arg Glu Glu Val Ile Phe Arg Glu Tyr 
1               5                   10                  15      


Ser Phe Ser Phe Tyr Pro Leu Asn Ile Phe Ala Pro Phe Val Leu Phe 
            20                  25                  30          


Pro Asp Tyr Phe Cys Leu Leu Gly Phe Ile Trp Leu Ser Met Asn Val 
        35                  40                  45              


Leu Leu Phe Trp Lys Thr Phe Leu Leu Tyr Asn Gln Gly Pro Glu Tyr 
    50                  55                  60                  


His Tyr Leu His Gln Met Leu Gly Leu Gly Leu Cys Leu Ser Arg Ala 
65                  70                  75                  80  


Ser Ala Ser Val Leu Asn Leu Asn Cys Ser Leu Ile Leu Leu Pro Met 
                85                  90                  95      


Cys Arg Thr Leu Leu Ala Tyr Leu Arg Gly Ser Gln Lys Val Pro Ser 
            100                 105                 110         


Arg Arg Thr Arg Arg Leu Leu Asp Lys Ser Arg Thr Phe His Ile Thr 
        115                 120                 125             


Cys Gly Val Thr Ile Cys Ile Phe Ser Gly Val His Val Ala Ala His 
    130                 135                 140                 


Leu Val Asn Ala Leu Asn Phe Ser Val Asn Tyr Ser Glu Asp Phe Val 
145                 150                 155                 160 


Glu Leu Asn Ala Ala Arg Tyr Arg Asp Glu Asp Pro Arg Lys Leu Leu 
                165                 170                 175     


Phe Thr Thr Val Pro Gly Leu Thr Gly Val Cys Met Val Val Val Leu 
            180                 185                 190         


Phe Leu Met Ile Thr Ala Ser Thr Tyr Ala Ile Arg Val Ser Asn Tyr 
        195                 200                 205             


Asp Ile Phe Trp Tyr Thr His Asn Leu Phe Phe Val Phe Tyr Met Leu 
    210                 215                 220                 


Leu Thr Leu His Val Ser Gly Gly Leu Leu Lys Tyr Gln Thr Asn Leu 
225                 230                 235                 240 


Asp Thr His Pro Pro Gly Cys Ile Ser Leu Asn Arg Thr Ser Ser Gln 
                245                 250                 255     


Asn Ile Ser Leu Pro Glu Tyr Phe Ser Glu His Phe His Glu Pro Phe 
            260                 265                 270         


Pro Glu Gly Phe Ser Lys Pro Ala Glu Phe Thr Gln His Lys Phe Val 
        275                 280                 285             


Lys Ile Cys Met Glu Glu Pro Arg Phe Gln Ala Asn Phe Pro Gln Thr 
    290                 295                 300                 


Trp Leu Trp Ile Ser Gly Pro Leu Cys Leu Tyr Cys Ala Glu Arg Leu 
305                 310                 315                 320 


Tyr Arg Tyr Ile Arg Ser Asn Lys Pro Val Thr Ile Ile Ser Val Ile 
                325                 330                 335     


Ser His Pro Ser Asp Val Met Glu Ile Arg Met Val Lys Glu Asn Phe 
            340                 345                 350         


Lys Ala Arg Pro Gly Gln Tyr Ile Thr Leu His Cys Pro Ser Val Ser 
        355                 360                 365             


Ala Leu Glu Asn His Pro Phe Thr Leu Thr Met Cys Pro Thr Glu Thr 
    370                 375                 380                 


Lys Ala Thr Phe Gly Val His Leu Lys Ile Val Gly Asp Trp Thr Glu 
385                 390                 395                 400 


Arg Phe Arg Asp Leu Leu Leu Pro Pro Ser Ser Gln Asp Ser Glu Ile 
                405                 410                 415     


Leu Pro Phe Ile Gln Ser Arg Asn Tyr Pro Lys Leu Tyr Ile Asp Gly 
            420                 425                 430         


Pro Phe Gly Ser Pro Phe Glu Glu Ser Leu Asn Tyr Glu Val Ser Leu 
        435                 440                 445             


Cys Val Ala Gly Gly Ile Gly Val Thr Pro Phe Ala Ser Ile Leu Asn 
    450                 455                 460                 


Thr Leu Leu Asp Asp Trp Lys Pro Tyr Lys Leu Arg Arg Leu Tyr Phe 
465                 470                 475                 480 


Ile Trp Val Cys Arg Asp Ile Gln Ser Phe Arg Trp Phe Ala Asp Leu 
                485                 490                 495     


Leu Cys Met Leu His Asn Lys Phe Trp Gln Glu Asn Arg Pro Asp Tyr 
            500                 505                 510         


Val Asn Ile Gln Leu Tyr Leu Ser Gln Thr Asp Gly Ile Gln Lys Ile 
        515                 520                 525             


Ile Gly Glu Lys Tyr His Ala Leu Asn Ser Arg Leu Phe Ile Gly Arg 
    530                 535                 540                 


Pro Arg Trp Lys Leu Leu Phe Asp Glu Ile Ala Lys Tyr Asn Arg Gly 
545                 550                 555                 560 


Lys Thr Val Gly Val Phe Cys Cys Gly Pro Asn Ser Leu Ser Lys Thr 
                565                 570                 575     


Leu His Lys Leu Ser Asn Gln Asn Asn Ser Tyr Gly Thr Arg Phe Glu 
            580                 585                 590         


Tyr Asn Lys Glu Ser Phe Ser 
        595                 


<210>  363
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  363

Met Asn Val Leu Leu Phe Trp Lys Thr Phe Leu Leu Tyr Asn Gln Gly 
1               5                   10                  15      


Pro Glu Tyr His Tyr Leu His Gln Met Leu Gly Leu Gly Leu Cys Leu 
            20                  25                  30          


Ser Arg Ala Ser Ala Ser Val Leu Asn Leu Asn Cys Ser Leu Ile Leu 
        35                  40                  45              


Leu Pro Met Cys Arg Thr Leu Leu Ala Tyr Leu Arg Gly Ser Gln Lys 
    50                  55                  60                  


Val Pro Ser Arg Arg Thr Arg Arg Leu Leu Asp Lys Ser Arg Thr Phe 
65                  70                  75                  80  


His Ile Thr Cys Gly Val Thr Ile Cys Ile Phe Ser Gly Val His Val 
                85                  90                  95      


Ala Ala His Leu Val Asn Ala Leu Asn Phe Ser Val Asn Tyr Ser Glu 
            100                 105                 110         


Asp Phe Val Glu Leu Asn Ala Ala Arg Tyr Arg Asp Glu Asp Pro Arg 
        115                 120                 125             


Lys Leu Leu Phe Thr Thr Val Pro Gly Leu Thr Gly Val Cys Met Val 
    130                 135                 140                 


Val Val Leu Phe Leu Met Ile Thr Ala Ser Thr Tyr Ala Ile Arg Val 
145                 150                 155                 160 


Ser Asn Tyr Asp Ile Phe Trp Tyr Thr His Asn Leu Phe Phe Val Phe 
                165                 170                 175     


Tyr Met Leu Leu Thr Leu His Val Ser Gly Gly Leu Leu Lys Tyr Gln 
            180                 185                 190         


Thr Asn Leu Asp Thr His Pro Pro Gly Cys Ile Ser Leu Asn Arg Thr 
        195                 200                 205             


Ser Ser Gln Asn Ile Ser Leu Pro Glu Tyr Phe Ser Glu His Phe His 
    210                 215                 220                 


Glu Pro Phe Pro Glu Gly Phe Ser Lys Pro Ala Glu Phe Thr Gln His 
225                 230                 235                 240 


Lys Phe Val Lys Ile Cys Met Glu Glu Pro Arg Phe Gln Ala Asn Phe 
                245                 250                 255     


Pro Gln Thr Trp Leu Trp Ile Ser Gly Pro Leu Cys Leu Tyr Cys Ala 
            260                 265                 270         


Glu Arg Leu Tyr Arg Tyr Ile Arg Ser Asn Lys Pro Val Thr Ile Ile 
        275                 280                 285             


Ser Val Met Ser His Pro Ser Asp Val Met Glu Ile Arg Met Val Lys 
    290                 295                 300                 


Glu Asn Phe Lys Ala Arg Pro Gly Gln Tyr Ile Thr Leu His Cys Pro 
305                 310                 315                 320 


Ser Val Ser Ala Leu Glu Asn His Pro Phe Thr Leu Thr Met Cys Pro 
                325                 330                 335     


Thr Glu Thr Lys Ala Thr Phe Gly Val His Leu Lys Ile Val Gly Asp 
            340                 345                 350         


Trp Thr Glu Arg Phe Arg Asp Leu Leu Leu Pro Pro Ser Ser Gln Asp 
        355                 360                 365             


Ser Glu Ile Leu Pro Phe Ile Gln Ser Arg Asn Tyr Pro Lys Asp Asp 
    370                 375                 380                 


Trp Lys Pro Tyr Lys Leu Arg Arg Leu Tyr Phe Ile Trp Val Cys Arg 
385                 390                 395                 400 


Asp Ile Gln Ser Phe Arg Trp Phe Ala Asp Leu Leu Cys Met Leu His 
                405                 410                 415     


Asn Lys Phe Trp Gln Glu Asn Arg Pro Asp Tyr Val Asn Ile Gln Leu 
            420                 425                 430         


Tyr Leu Ser Gln Thr Asp Gly Ile Gln Lys Ile Ile Gly Glu Lys Tyr 
        435                 440                 445             


His Ala Leu Asn Ser Arg Leu Phe Ile Gly Arg Pro Arg Trp Lys Leu 
    450                 455                 460                 


Leu Phe Asp Glu Ile Ala Lys Tyr Asn Arg Gly Lys Thr Val Gly Val 
465                 470                 475                 480 


Phe Cys Cys Gly Pro Asn Ser Leu Ser Lys Thr Leu His Lys Leu Ser 
                485                 490                 495     


Asn Gln Asn Asn Ser Tyr Gly Thr Arg Phe Glu Tyr Asn Lys Glu Ser 
            500                 505                 510         


Phe Ser 
        


<210>  364
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Ala Val Ser Trp Arg Ser Trp Leu Ala Asn Glu Gly Val Lys His 
1               5                   10                  15      


Leu Cys Leu Phe Ile Trp Leu Ser Met Asn Val Leu Leu Phe Trp Lys 
            20                  25                  30          


Thr Phe Leu Leu Tyr Asn Gln Gly Pro Glu Tyr His Tyr Leu His Gln 
        35                  40                  45              


Met Leu Gly Leu Gly Leu Cys Leu Ser Arg Ala Ser Ala Ser Val Leu 
    50                  55                  60                  


Asn Leu Asn Cys Ser Leu Ile Leu Leu Pro Met Cys Arg Thr Leu Leu 
65                  70                  75                  80  


Ala Tyr Leu Arg Gly Ser Gln Lys Val Pro Ser Arg Arg Thr Arg Arg 
                85                  90                  95      


Leu Leu Asp Lys Ser Arg Thr Phe His Ile Thr Cys Gly Val Thr Ile 
            100                 105                 110         


Cys Ile Phe Ser Gly Val His Val Ala Ala His Leu Val Asn Ala Leu 
        115                 120                 125             


Asn Phe Ser Val Asn Tyr Ser Glu Asp Phe Val Glu Leu Asn Ala Ala 
    130                 135                 140                 


Arg Tyr Arg Asp Glu Asp Pro Arg Lys Leu Leu Phe Thr Thr Val Pro 
145                 150                 155                 160 


Gly Leu Thr Gly Val Cys Met Val Val Val Leu Phe Leu Met Ile Thr 
                165                 170                 175     


Ala Ser Thr Tyr Ala Ile Arg Val Ser Asn Tyr Asp Ile Phe Trp Tyr 
            180                 185                 190         


Thr His Asn Leu Phe Phe Val Phe Tyr Met Leu Leu Thr Leu His Val 
        195                 200                 205             


Ser Gly Gly Leu Leu Lys Tyr Gln Thr Asn Leu Asp Thr His Pro Pro 
    210                 215                 220                 


Gly Cys Ile Ser Leu Asn Arg Thr Ser Ser Gln Asn Ile Ser Leu Pro 
225                 230                 235                 240 


Glu Tyr Phe Ser Glu His Phe His Glu Pro Phe Pro Glu Gly Phe Ser 
                245                 250                 255     


Lys Pro Ala Glu Phe Thr Gln His Lys Phe Val Lys Ile Cys Met Glu 
            260                 265                 270         


Glu Pro Arg Phe Gln Ala Asn Phe Pro Gln Thr Trp Leu Trp Ile Ser 
        275                 280                 285             


Gly Pro Leu Cys Leu Tyr Cys Ala Glu Arg Leu Tyr Arg Tyr Ile Arg 
    290                 295                 300                 


Ser Asn Lys Pro Val Thr Ile Ile Ser Val Ile Ser His Pro Ser Asp 
305                 310                 315                 320 


Val Met Glu Ile Arg Met Val Lys Glu Asn Phe Lys Ala Arg Pro Gly 
                325                 330                 335     


Gln Tyr Ile Thr Leu His Cys Pro Ser Val Ser Ala Leu Glu Asn His 
            340                 345                 350         


Pro Phe Thr Leu Thr Met Cys Pro Thr Glu Thr Lys Ala Thr Phe Gly 
        355                 360                 365             


Val His Leu Lys Ile Val Gly Asp Trp Thr Glu Arg Phe Arg Asp Leu 
    370                 375                 380                 


Leu Leu Pro Pro Ser Ser Gln Asp Ser Glu Ile Leu Pro Phe Ile Gln 
385                 390                 395                 400 


Ser Arg Asn Tyr Pro Lys Leu Tyr Ile Asp Gly Pro Phe Gly Ser Pro 
                405                 410                 415     


Phe Glu Glu Ser Leu Asn Tyr Glu Val Ser Leu Cys Val Ala Gly Gly 
            420                 425                 430         


Ile Gly Val Thr Pro Phe Ala Ser Ile Leu Asn Thr Leu Leu Asp Asp 
        435                 440                 445             


Trp Lys Pro Tyr Lys Leu Arg Arg Leu Tyr Phe Ile Trp Val Cys Arg 
    450                 455                 460                 


Asp Ile Gln Ser Phe Arg Trp Phe Ala Asp Leu Leu Cys Met Leu His 
465                 470                 475                 480 


Asn Lys Phe Trp Gln Glu Asn Arg Pro Asp Tyr Val Asn Ile Gln Leu 
                485                 490                 495     


Tyr Leu Ser Gln Thr Asp Gly Ile Gln Lys Ile Ile Gly Glu Lys Tyr 
            500                 505                 510         


His Ala Leu Asn Ser Arg Leu Phe Ile Gly Arg Pro Arg Trp Lys Leu 
        515                 520                 525             


Leu Phe Asp Glu Ile Ala Lys Tyr Asn Arg Gly Lys Thr Val Gly Val 
    530                 535                 540                 


Phe Cys Cys Gly Pro Asn Ser Leu Ser Lys Thr Leu His Lys Leu Ser 
545                 550                 555                 560 


Asn Gln Asn Asn Ser Tyr Gly Thr Arg Phe Glu Tyr Asn Lys Glu Ser 
                565                 570                 575     


Phe Ser 
        


<210>  365
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  365

Met Glu Gly Glu Pro Ser Gln Pro Pro Asn Ser Ser Trp Pro Leu Ser 
1               5                   10                  15      


Gln Asn Gly Thr Asn Thr Glu Ala Thr Pro Ala Thr Asn Leu Thr Phe 
            20                  25                  30          


Ser Ser Tyr Tyr Gln His Thr Ser Pro Val Ala Ala Met Phe Ile Val 
        35                  40                  45              


Ala Tyr Ala Leu Ile Phe Leu Leu Cys Met Val Gly Asn Thr Leu Val 
    50                  55                  60                  


Cys Phe Ile Val Leu Lys Asn Arg His Met His Thr Val Thr Asn Met 
65                  70                  75                  80  


Phe Ile Leu Asn Leu Ala Val Ser Asp Leu Leu Val Gly Ile Phe Cys 
                85                  90                  95      


Met Pro Thr Thr Leu Val Asp Asn Leu Ile Thr Gly Trp Pro Phe Asp 
            100                 105                 110         


Asn Ala Thr Cys Lys Met Ser Gly Leu Val Gln Gly Met Ser Val Ser 
        115                 120                 125             


Ala Ser Val Phe Thr Leu Val Ala Ile Ala Val Glu Arg Phe Arg Cys 
    130                 135                 140                 


Ile Val His Pro Phe Arg Glu Lys Leu Thr Leu Arg Lys Ala Leu Val 
145                 150                 155                 160 


Thr Ile Ala Val Ile Trp Ala Leu Ala Leu Leu Ile Met Cys Pro Ser 
                165                 170                 175     


Ala Val Thr Leu Thr Val Thr Arg Glu Glu His His Phe Met Val Asp 
            180                 185                 190         


Ala Arg Asn Arg Ser Tyr Pro Leu Tyr Ser Cys Trp Glu Ala Trp Pro 
        195                 200                 205             


Glu Lys Gly Met Arg Arg Val Tyr Thr Thr Val Leu Phe Ser His Ile 
    210                 215                 220                 


Tyr Leu Ala Pro Leu Ala Leu Ile Val Val Met Tyr Ala Arg Ile Ala 
225                 230                 235                 240 


Arg Lys Leu Cys Gln Ala Pro Gly Pro Ala Pro Gly Gly Glu Glu Ala 
                245                 250                 255     


Ala Asp Pro Arg Ala Ser Arg Arg Arg Ala Arg Val Val His Met Leu 
            260                 265                 270         


Val Met Val Ala Leu Phe Phe Thr Leu Ser Trp Leu Pro Leu Trp Ala 
        275                 280                 285             


Leu Leu Leu Leu Ile Asp Tyr Gly Gln Leu Ser Ala Pro Gln Leu His 
    290                 295                 300                 


Leu Val Thr Val Tyr Ala Phe Pro Phe Ala His Trp Leu Ala Phe Phe 
305                 310                 315                 320 


Asn Ser Ser Ala Asn Pro Ile Ile Tyr Gly Tyr Phe Asn Glu Asn Phe 
                325                 330                 335     


Arg Arg Gly Phe Gln Ala Ala Phe Arg Ala Arg Leu Cys Pro Arg Pro 
            340                 345                 350         


Ser Gly Ser His Lys Glu Ala Tyr Ser Glu Arg Pro Gly Gly Leu Leu 
        355                 360                 365             


His Arg Arg Val Phe Val Val Val Arg Pro Ser Asp Ser Gly Leu Pro 
    370                 375                 380                 


Ser Glu Ser Gly Pro Ser Ser Gly Ala Pro Arg Pro Gly Arg Leu Pro 
385                 390                 395                 400 


Leu Arg Asn Gly Arg Val Ala His His Gly Leu Pro Arg Glu Gly Pro 
                405                 410                 415     


Gly Cys Ser His Leu Pro Leu Thr Ile Pro Ala Trp Asp Ile 
            420                 425                 430 


<210>  366
<211>  1304
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
        115                 120                 125             


Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
    130                 135                 140                 


Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
145                 150                 155                 160 


Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                165                 170                 175     


Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
            180                 185                 190         


Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
        195                 200                 205             


Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
    210                 215                 220                 


Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
225                 230                 235                 240 


Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu 
                245                 250                 255     


Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr 
            260                 265                 270         


Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu 
        275                 280                 285             


Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp 
    290                 295                 300                 


Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn 
305                 310                 315                 320 


Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly 
                325                 330                 335     


Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr 
            340                 345                 350         


Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln 
        355                 360                 365             


Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala 
    370                 375                 380                 


Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro 
385                 390                 395                 400 


Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr 
                405                 410                 415     


Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys 
            420                 425                 430         


Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn 
        435                 440                 445             


Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr 
    450                 455                 460                 


Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly 
465                 470                 475                 480 


Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala 
                485                 490                 495     


Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile 
            500                 505                 510         


Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg 
        515                 520                 525             


Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp 
    530                 535                 540                 


Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly 
545                 550                 555                 560 


Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser 
                565                 570                 575     


Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu 
            580                 585                 590         


Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp 
        595                 600                 605             


Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser 
    610                 615                 620                 


Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
                645                 650                 655     


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
            660                 665                 670         


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
        675                 680                 685             


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
    690                 695                 700                 


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
705                 710                 715                 720 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
                725                 730                 735     


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
            740                 745                 750         


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
        755                 760                 765             


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val 
    770                 775                 780                 


Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val 
785                 790                 795                 800 


Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro 
                805                 810                 815     


Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu 
            820                 825                 830         


Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala 
        835                 840                 845             


Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val 
    850                 855                 860                 


His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly 
865                 870                 875                 880 


Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg 
                885                 890                 895     


Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His 
            900                 905                 910         


Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val 
        915                 920                 925             


Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val 
    930                 935                 940                 


Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile 
945                 950                 955                 960 


Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser 
                965                 970                 975     


His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile 
            980                 985                 990         


Asn Ser Thr His Glu Leu Gly Pro  Leu Val Asp Leu Lys  Ile Pro Ala 
        995                 1000                 1005             


Asn Lys  Thr Arg Trp Thr Leu  Lys Asn Leu Asn Phe  Ser Thr Arg 
    1010                 1015                 1020             


Tyr Lys  Phe Tyr Phe Tyr Ala  Gln Thr Ser Ala Gly  Ser Gly Ser 
    1025                 1030                 1035             


Gln Ile  Thr Glu Glu Ala Val  Thr Thr Val Asp Glu  Ala Gly Ile 
    1040                 1045                 1050             


Leu Pro  Pro Asp Val Gly Ala  Gly Lys Val Gln Ala  Val Asn Pro 
    1055                 1060                 1065             


Arg Ile  Ser Asn Leu Thr Ala  Ala Ala Ala Glu Thr  Tyr Ala Asn 
    1070                 1075                 1080             


Ile Ser  Trp Glu Tyr Glu Gly  Pro Glu His Val Asn  Phe Tyr Val 
    1085                 1090                 1095             


Glu Tyr  Gly Val Ala Gly Ser  Lys Glu Glu Trp Arg  Lys Glu Ile 
    1100                 1105                 1110             


Val Asn  Gly Ser Arg Ser Phe  Phe Gly Leu Lys Gly  Leu Met Pro 
    1115                 1120                 1125             


Gly Thr  Ala Tyr Lys Val Arg  Val Gly Ala Val Gly  Asp Ser Gly 
    1130                 1135                 1140             


Phe Val  Ser Ser Glu Asp Val  Phe Glu Thr Gly Pro  Ala Met Ala 
    1145                 1150                 1155             


Ser Arg  Gln Val Asp Ile Ala  Thr Gln Gly Trp Phe  Ile Gly Leu 
    1160                 1165                 1170             


Met Cys  Ala Val Ala Leu Leu  Ile Leu Ile Leu Leu  Ile Val Cys 
    1175                 1180                 1185             


Phe Ile  Arg Arg Asn Lys Gly  Gly Lys Tyr Pro Val  Lys Glu Lys 
    1190                 1195                 1200             


Glu Asp  Ala His Ala Asp Pro  Glu Ile Gln Pro Met  Lys Glu Asp 
    1205                 1210                 1215             


Asp Gly  Thr Phe Gly Glu Tyr  Ser Asp Ala Glu Asp  His Lys Pro 
    1220                 1225                 1230             


Leu Lys  Lys Gly Ser Arg Thr  Pro Ser Asp Arg Thr  Val Lys Lys 
    1235                 1240                 1245             


Glu Asp  Ser Asp Asp Ser Leu  Val Asp Tyr Gly Glu  Gly Val Asn 
    1250                 1255                 1260             


Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile Gly Gln  Tyr Ser Gly 
    1265                 1270                 1275             


Lys Lys  Glu Lys Glu Pro Ala  Glu Gly Asn Glu Ser  Ser Glu Ala 
    1280                 1285                 1290             


Pro Ser  Pro Val Asn Ala Met  Asn Ser Phe Val 
    1295                 1300                 


<210>  367
<211>  1211
<212>  PRT
<213>  Homo sapiens

<400>  367

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
        115                 120                 125             


Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
    130                 135                 140                 


Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
145                 150                 155                 160 


Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                165                 170                 175     


Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
            180                 185                 190         


Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
        195                 200                 205             


Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
    210                 215                 220                 


Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
225                 230                 235                 240 


Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu 
                245                 250                 255     


Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr 
            260                 265                 270         


Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu 
        275                 280                 285             


Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp 
    290                 295                 300                 


Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn 
305                 310                 315                 320 


Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly 
                325                 330                 335     


Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr 
            340                 345                 350         


Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln 
        355                 360                 365             


Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala 
    370                 375                 380                 


Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro 
385                 390                 395                 400 


Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr 
                405                 410                 415     


Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys 
            420                 425                 430         


Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn 
        435                 440                 445             


Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr 
    450                 455                 460                 


Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly 
465                 470                 475                 480 


Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala 
                485                 490                 495     


Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile 
            500                 505                 510         


Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg 
        515                 520                 525             


Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp 
    530                 535                 540                 


Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly 
545                 550                 555                 560 


Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser 
                565                 570                 575     


Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu 
            580                 585                 590         


Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp 
        595                 600                 605             


Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser 
    610                 615                 620                 


Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
                645                 650                 655     


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
            660                 665                 670         


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
        675                 680                 685             


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
    690                 695                 700                 


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
705                 710                 715                 720 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
                725                 730                 735     


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
            740                 745                 750         


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
        755                 760                 765             


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val 
    770                 775                 780                 


Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val 
785                 790                 795                 800 


Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro 
                805                 810                 815     


Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu 
            820                 825                 830         


Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala 
        835                 840                 845             


Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val 
    850                 855                 860                 


His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly 
865                 870                 875                 880 


Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg 
                885                 890                 895     


Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His 
            900                 905                 910         


Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val 
        915                 920                 925             


Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val 
    930                 935                 940                 


Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile 
945                 950                 955                 960 


Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser 
                965                 970                 975     


His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile 
            980                 985                 990         


Asn Ser Thr His Glu Leu Gly Pro  Leu Val Asp Leu Lys  Ile Pro Ala 
        995                 1000                 1005             


Asn Lys  Thr Arg Trp Thr Leu  Lys Asn Leu Asn Phe  Ser Thr Arg 
    1010                 1015                 1020             


Tyr Lys  Phe Tyr Phe Tyr Ala  Gln Thr Ser Ala Gly  Ser Gly Ser 
    1025                 1030                 1035             


Gln Ile  Thr Glu Glu Ala Val  Thr Thr Val Asp Glu  Ala Gly Ile 
    1040                 1045                 1050             


Leu Pro  Pro Asp Val Gly Ala  Gly Lys Ala Met Ala  Ser Arg Gln 
    1055                 1060                 1065             


Val Asp  Ile Ala Thr Gln Gly  Trp Phe Ile Gly Leu  Met Cys Ala 
    1070                 1075                 1080             


Val Ala  Leu Leu Ile Leu Ile  Leu Leu Ile Val Cys  Phe Ile Arg 
    1085                 1090                 1095             


Arg Asn  Lys Gly Gly Lys Tyr  Pro Val Lys Glu Lys  Glu Asp Ala 
    1100                 1105                 1110             


His Ala  Asp Pro Glu Ile Gln  Pro Met Lys Glu Asp  Asp Gly Thr 
    1115                 1120                 1125             


Phe Gly  Glu Tyr Ser Asp Ala  Glu Asp His Lys Pro  Leu Lys Lys 
    1130                 1135                 1140             


Gly Ser  Arg Thr Pro Ser Asp  Arg Thr Val Lys Lys  Glu Asp Ser 
    1145                 1150                 1155             


Asp Asp  Ser Leu Val Asp Tyr  Gly Glu Gly Val Asn  Gly Gln Phe 
    1160                 1165                 1170             


Asn Glu  Asp Gly Ser Phe Ile  Gly Gln Tyr Ser Gly  Lys Lys Glu 
    1175                 1180                 1185             


Lys Glu  Pro Ala Glu Gly Asn  Glu Ser Ser Glu Ala  Pro Ser Pro 
    1190                 1195                 1200             


Val Asn  Ala Met Asn Ser Phe  Val 
    1205                 1210     


<210>  368
<211>  1192
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
        115                 120                 125             


Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
    130                 135                 140                 


Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
145                 150                 155                 160 


Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                165                 170                 175     


Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
            180                 185                 190         


Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
        195                 200                 205             


Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
    210                 215                 220                 


Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
225                 230                 235                 240 


Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly 
                245                 250                 255     


Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu 
            260                 265                 270         


Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu 
        275                 280                 285             


Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys 
    290                 295                 300                 


Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln 
305                 310                 315                 320 


Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val 
                325                 330                 335     


Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val 
            340                 345                 350         


Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn 
        355                 360                 365             


Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile 
    370                 375                 380                 


Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe 
385                 390                 395                 400 


Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser 
                405                 410                 415     


Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala 
            420                 425                 430         


Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile 
        435                 440                 445             


Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu 
    450                 455                 460                 


Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu 
465                 470                 475                 480 


Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala 
                485                 490                 495     


Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu 
            500                 505                 510         


Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Pro Thr Trp 
        515                 520                 525             


Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val 
    530                 535                 540                 


Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val 
545                 550                 555                 560 


Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr 
                565                 570                 575     


Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser 
            580                 585                 590         


Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala 
        595                 600                 605             


Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val 
    610                 615                 620                 


Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu 
625                 630                 635                 640 


Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser 
                645                 650                 655     


Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro 
            660                 665                 670         


Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala 
        675                 680                 685             


Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala 
    690                 695                 700                 


Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr 
705                 710                 715                 720 


Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly 
                725                 730                 735     


Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn 
            740                 745                 750         


Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg 
        755                 760                 765             


Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val 
    770                 775                 780                 


Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile 
785                 790                 795                 800 


Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val 
                805                 810                 815     


Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn 
            820                 825                 830         


Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp 
        835                 840                 845             


Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile 
    850                 855                 860                 


Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile 
865                 870                 875                 880 


Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu 
                885                 890                 895     


Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val 
            900                 905                 910         


Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr 
        915                 920                 925             


Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro 
    930                 935                 940                 


Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn 
945                 950                 955                 960 


Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr 
                965                 970                 975     


His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr 
            980                 985                 990         


Arg Trp Thr Leu Lys Asn Leu Asn  Phe Ser Thr Arg Tyr  Lys Phe Tyr 
        995                 1000                 1005             


Phe Tyr  Ala Gln Thr Ser Ala  Gly Ser Gly Ser Gln  Ile Thr Glu 
    1010                 1015                 1020             


Glu Ala  Val Thr Thr Val Asp  Glu Ala Gly Ile Leu  Pro Pro Asp 
    1025                 1030                 1035             


Val Gly  Ala Gly Lys Ala Met  Ala Ser Arg Gln Val  Asp Ile Ala 
    1040                 1045                 1050             


Thr Gln  Gly Trp Phe Ile Gly  Leu Met Cys Ala Val  Ala Leu Leu 
    1055                 1060                 1065             


Ile Leu  Ile Leu Leu Ile Val  Cys Phe Ile Arg Arg  Asn Lys Gly 
    1070                 1075                 1080             


Gly Lys  Tyr Pro Val Lys Glu  Lys Glu Asp Ala His  Ala Asp Pro 
    1085                 1090                 1095             


Glu Ile  Gln Pro Met Lys Glu  Asp Asp Gly Thr Phe  Gly Glu Tyr 
    1100                 1105                 1110             


Ser Asp  Ala Glu Asp His Lys  Pro Leu Lys Lys Gly  Ser Arg Thr 
    1115                 1120                 1125             


Pro Ser  Asp Arg Thr Val Lys  Lys Glu Asp Ser Asp  Asp Ser Leu 
    1130                 1135                 1140             


Val Asp  Tyr Gly Glu Gly Val  Asn Gly Gln Phe Asn  Glu Asp Gly 
    1145                 1150                 1155             


Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys Glu Lys  Glu Pro Ala 
    1160                 1165                 1170             


Glu Gly  Asn Glu Ser Ser Glu  Ala Pro Ser Pro Val  Asn Ala Met 
    1175                 1180                 1185             


Asn Ser  Phe Val 
    1190         


<210>  369
<211>  1180
<212>  PRT
<213>  Homo sapiens

<400>  369

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
        115                 120                 125             


Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
    130                 135                 140                 


Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
145                 150                 155                 160 


Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                165                 170                 175     


Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
            180                 185                 190         


Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
        195                 200                 205             


Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
    210                 215                 220                 


Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
225                 230                 235                 240 


Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly 
                245                 250                 255     


Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu 
            260                 265                 270         


Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu 
        275                 280                 285             


Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys 
    290                 295                 300                 


Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln 
305                 310                 315                 320 


Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val 
                325                 330                 335     


Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val 
            340                 345                 350         


Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn 
        355                 360                 365             


Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile 
    370                 375                 380                 


Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe 
385                 390                 395                 400 


Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser 
                405                 410                 415     


Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala 
            420                 425                 430         


Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile 
        435                 440                 445             


Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu 
    450                 455                 460                 


Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu 
465                 470                 475                 480 


Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala 
                485                 490                 495     


Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu 
            500                 505                 510         


Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Pro Thr Trp 
        515                 520                 525             


Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val 
    530                 535                 540                 


Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val 
545                 550                 555                 560 


Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr 
                565                 570                 575     


Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser 
            580                 585                 590         


Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala 
        595                 600                 605             


Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val 
    610                 615                 620                 


Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu 
625                 630                 635                 640 


Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser 
                645                 650                 655     


Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro 
            660                 665                 670         


Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala 
        675                 680                 685             


Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala 
    690                 695                 700                 


Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr 
705                 710                 715                 720 


Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly 
                725                 730                 735     


Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn 
            740                 745                 750         


Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg 
        755                 760                 765             


Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val 
    770                 775                 780                 


Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile 
785                 790                 795                 800 


Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val 
                805                 810                 815     


Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn 
            820                 825                 830         


Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp 
        835                 840                 845             


Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile 
    850                 855                 860                 


Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile 
865                 870                 875                 880 


Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu 
                885                 890                 895     


Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val 
            900                 905                 910         


Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr 
        915                 920                 925             


Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro 
    930                 935                 940                 


Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn 
945                 950                 955                 960 


Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr 
                965                 970                 975     


His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr 
            980                 985                 990         


Arg Trp Thr Leu Lys Asn Leu Asn  Phe Ser Thr Arg Tyr  Lys Phe Tyr 
        995                 1000                 1005             


Phe Tyr  Ala Gln Thr Ser Ala  Gly Ser Gly Ser Gln  Ile Thr Glu 
    1010                 1015                 1020             


Glu Ala  Val Thr Thr Val Asp  Glu Ala Met Ala Ser  Arg Gln Val 
    1025                 1030                 1035             


Asp Ile  Ala Thr Gln Gly Trp  Phe Ile Gly Leu Met  Cys Ala Val 
    1040                 1045                 1050             


Ala Leu  Leu Ile Leu Ile Leu  Leu Ile Val Cys Phe  Ile Arg Arg 
    1055                 1060                 1065             


Asn Lys  Gly Gly Lys Tyr Pro  Val Lys Glu Lys Glu  Asp Ala His 
    1070                 1075                 1080             


Ala Asp  Pro Glu Ile Gln Pro  Met Lys Glu Asp Asp  Gly Thr Phe 
    1085                 1090                 1095             


Gly Glu  Tyr Ser Asp Ala Glu  Asp His Lys Pro Leu  Lys Lys Gly 
    1100                 1105                 1110             


Ser Arg  Thr Pro Ser Asp Arg  Thr Val Lys Lys Glu  Asp Ser Asp 
    1115                 1120                 1125             


Asp Ser  Leu Val Asp Tyr Gly  Glu Gly Val Asn Gly  Gln Phe Asn 
    1130                 1135                 1140             


Glu Asp  Gly Ser Phe Ile Gly  Gln Tyr Ser Gly Lys  Lys Glu Lys 
    1145                 1150                 1155             


Glu Pro  Ala Glu Gly Asn Glu  Ser Ser Glu Ala Pro  Ser Pro Val 
    1160                 1165                 1170             


Asn Ala  Met Asn Ser Phe Val  
    1175                 1180 


<210>  370
<211>  1183
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro Lys 
        35                  40                  45              


Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu Ala 
    50                  55                  60                  


Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr His 
65                  70                  75                  80  


Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr Gly 
                85                  90                  95      


Thr Leu Ile Ile Asn Ile Met Ser Glu Gly Lys Ala Glu Thr Tyr Glu 
            100                 105                 110         


Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu Arg Gly Ala Ala Val Ser 
        115                 120                 125             


Asn Asn Ile Val Val Arg Pro Ser Arg Ser Pro Leu Trp Thr Lys Glu 
    130                 135                 140                 


Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly Gln Ser Leu Val Leu Pro 
145                 150                 155                 160 


Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro Ile Ile Phe Trp Met Asp 
                165                 170                 175     


Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu Arg Val Ser Gln Gly Leu 
            180                 185                 190         


Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu Pro Glu Asp Thr Arg Glu 
        195                 200                 205             


Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His Thr Gln Thr Ile Gln Gln 
    210                 215                 220                 


Lys Gln Pro Ile Ser Val Lys Val Ile Ser Val Asp Glu Leu Asn Asp 
225                 230                 235                 240 


Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu Phe Tyr Gly Ala Lys Ser 
                245                 250                 255     


Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly Asn Ala Ser 
            260                 265                 270         


Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu Cys Ile Ala 
        275                 280                 285             


Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu Asp Gly Met 
    290                 295                 300                 


Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys Thr Leu Gln 
305                 310                 315                 320 


Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln Cys Ile Ala 
                325                 330                 335     


Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val Arg Val Lys 
            340                 345                 350         


Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val Leu Ser Pro 
        355                 360                 365             


Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn Pro Lys Pro 
    370                 375                 380                 


Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile Ala Pro Asp 
385                 390                 395                 400 


Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe Ser Asn Val 
                405                 410                 415     


Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser Asn Glu Tyr 
            420                 425                 430         


Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala Glu Pro Pro 
        435                 440                 445             


Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile Ala Asn Arg 
    450                 455                 460                 


Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu Pro Thr Ile 
465                 470                 475                 480 


Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu Asp Ile Tyr 
                485                 490                 495     


Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala Gln Lys Asp 
            500                 505                 510         


Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu Gly Met Ala 
        515                 520                 525             


Lys Asn Glu Val His Leu Glu Ile Lys Asp Pro Thr Trp Ile Val Lys 
    530                 535                 540                 


Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val Ser Phe Glu 
545                 550                 555                 560 


Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val Leu Trp Leu 
                565                 570                 575     


Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr Val Asp Lys 
            580                 585                 590         


Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser Gly Thr Tyr 
        595                 600                 605             


Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala Ser Ala Val 
    610                 615                 620                 


Leu Ser Val Val Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
625                 630                 635                 640 


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
                645                 650                 655     


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
            660                 665                 670         


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
        675                 680                 685             


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
    690                 695                 700                 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
705                 710                 715                 720 


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
                725                 730                 735     


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
            740                 745                 750         


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val 
        755                 760                 765             


Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val 
    770                 775                 780                 


Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro 
785                 790                 795                 800 


Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu 
                805                 810                 815     


Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala 
            820                 825                 830         


Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val 
        835                 840                 845             


His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly 
    850                 855                 860                 


Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg 
865                 870                 875                 880 


Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His 
                885                 890                 895     


Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val 
            900                 905                 910         


Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val 
        915                 920                 925             


Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile 
    930                 935                 940                 


Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser 
945                 950                 955                 960 


His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile 
                965                 970                 975     


Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala 
            980                 985                 990         


Asn Lys Thr Arg Trp Thr Leu Lys  Asn Leu Asn Phe Ser  Thr Arg Tyr 
        995                 1000                 1005             


Lys Phe  Tyr Phe Tyr Ala Gln  Thr Ser Ala Gly Ser  Gly Ser Gln 
    1010                 1015                 1020             


Ile Thr  Glu Glu Ala Val Thr  Thr Val Asp Glu Ala  Met Ala Ser 
    1025                 1030                 1035             


Arg Gln  Val Asp Ile Ala Thr  Gln Gly Trp Phe Ile  Gly Leu Met 
    1040                 1045                 1050             


Cys Ala  Val Ala Leu Leu Ile  Leu Ile Leu Leu Ile  Val Cys Phe 
    1055                 1060                 1065             


Ile Arg  Arg Asn Lys Gly Gly  Lys Tyr Pro Val Lys  Glu Lys Glu 
    1070                 1075                 1080             


Asp Ala  His Ala Asp Pro Glu  Ile Gln Pro Met Lys  Glu Asp Asp 
    1085                 1090                 1095             


Gly Thr  Phe Gly Glu Tyr Ser  Asp Ala Glu Asp His  Lys Pro Leu 
    1100                 1105                 1110             


Lys Lys  Gly Ser Arg Thr Pro  Ser Asp Arg Thr Val  Lys Lys Glu 
    1115                 1120                 1125             


Asp Ser  Asp Asp Ser Leu Val  Asp Tyr Gly Glu Gly  Val Asn Gly 
    1130                 1135                 1140             


Gln Phe  Asn Glu Asp Gly Ser  Phe Ile Gly Gln Tyr  Ser Gly Lys 
    1145                 1150                 1155             


Lys Glu  Lys Glu Pro Ala Glu  Gly Asn Glu Ser Ser  Glu Ala Pro 
    1160                 1165                 1170             


Ser Pro  Val Asn Ala Met Asn  Ser Phe Val 
    1175                 1180             


<210>  371
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  371

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Gly Ile Lys 
                


<210>  372
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Gly Gly Thr Thr Val Leu 
            580                 585                 590         


Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Gly Ile 
        595                 600                 605             


Lys 
    


<210>  373
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Arg Ser Thr Pro Gly Tyr 
                805                 810                 815     


Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn 
            820                 825                 830         


Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met Ser 
        835                 840                 845             


Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr Cys 
    850                 855                 860                 


Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu Glu 
865                 870                 875                 880 


Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp Lys 
                885                 890                 895     


Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
            900                 905     


<210>  374
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  375
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  375

Met Met Pro Ser Cys Asn Arg Ser Cys Ser Cys Ser Arg Gly Pro Ser 
1               5                   10                  15      


Val Glu Asp Gly Lys Trp Tyr Gly Val Arg Ser Tyr Leu His Leu Phe 
            20                  25                  30          


Tyr Glu Asp Cys Ala Gly Thr Ala Leu Ser Asp Asp Pro Glu Gly Pro 
        35                  40                  45              


Pro Val Leu Cys Pro Arg Arg Pro Trp Pro Ser Leu Cys Trp Lys Ile 
    50                  55                  60                  


Ser Leu Ser Ser Gly Thr Leu Leu Leu Leu Leu Gly Val Ala Ala Leu 
65                  70                  75                  80  


Thr Thr Gly Tyr Ala Val Pro Pro Lys Leu Glu Gly Ile Gly Glu Gly 
                85                  90                  95      


Trp Leu Ser Gln Asp Thr Lys Ala Glu Pro Leu Asp Pro Glu Ala Asp 
            100                 105                 110         


Ser His Val Glu Val Phe Gly Asp Glu Pro Glu Gln Gln Leu Ser Pro 
        115                 120                 125             


Ile Phe Arg Asn Ala Ser Gly Gln Ser Trp Phe Ser Pro Pro Ala Ser 
    130                 135                 140                 


Pro Phe Gly Gln Ser Ser Val Gln Thr Ile Gln Pro Lys Arg Asp Ser 
145                 150                 155                 160 


<210>  376
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  376

Met Met Pro Ser Cys Asn Arg Ser Cys Ser Cys Ser Arg Gly Pro Ser 
1               5                   10                  15      


Val Glu Asp Gly Lys Trp Tyr Gly Val Arg Ser Tyr Leu His Leu Phe 
            20                  25                  30          


Tyr Glu Asp Cys Ala Gly Thr Ala Leu Ser Asp Asp Pro Glu Gly Pro 
        35                  40                  45              


Pro Val Leu Cys Pro Arg Arg Pro Trp Pro Ser Leu Cys Trp Lys Ile 
    50                  55                  60                  


Ser Leu Ser Ser Gly Thr Leu Leu Leu Leu Leu Gly Val Ala Ala Leu 
65                  70                  75                  80  


Thr Thr Gly Tyr Ala Val Pro Pro Lys Leu Glu Gly Ile Gly Glu Gly 
                85                  90                  95      


Glu Phe Leu Val Leu Asp Gln Arg Ala Ala Asp Tyr Asn Gln Ala Leu 
            100                 105                 110         


Gly Thr Cys Arg Leu Ala Gly Thr Ala Leu Cys Val Ala Ala Gly Val 
        115                 120                 125             


Leu Leu Ala Ile Cys Leu Phe Trp Ala Met Ile Gly Trp Leu Ser Gln 
    130                 135                 140                 


Asp Thr Lys Ala Glu Pro Leu Asp Pro Glu Ala Asp Ser His Val Glu 
145                 150                 155                 160 


Val Phe Gly Asp Glu Pro Glu Gln Gln Leu Ser Pro Ile Phe Arg Asn 
                165                 170                 175     


Ala Ser Gly Gln Ser Trp Phe Ser Pro Pro Ala Ser Pro Phe Gly Gln 
            180                 185                 190         


Ser Ser Val Gln Thr Ile Gln Pro Lys Arg Asp Ser 
        195                 200                 


<210>  377
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  377

Met Met Pro Ser Cys Asn Arg Ser Cys Ser Cys Ser Arg Gly Pro Ser 
1               5                   10                  15      


Val Glu Asp Gly Lys Trp Tyr Gly Val Arg Ser Tyr Leu His Leu Phe 
            20                  25                  30          


Tyr Glu Asp Cys Ala Gly Thr Ala Leu Ser Asp Asp Pro Glu Gly Pro 
        35                  40                  45              


Pro Val Leu Cys Pro Arg Arg Pro Trp Pro Ser Leu Cys Trp Lys Ile 
    50                  55                  60                  


Ser Leu Ser Ser Gly Thr Leu Leu Leu Leu Leu Gly Val Ala Ala Leu 
65                  70                  75                  80  


Thr Thr Gly Tyr Ala Val Pro Pro Lys Leu Glu Gly Ile Gly Glu Gly 
                85                  90                  95      


Glu Phe Leu Val Leu Asp Gln Arg Ala Ala Asp Tyr Asn Gln Ala Leu 
            100                 105                 110         


Gly Thr Cys Arg Leu Ala Gly Thr Ala Leu Cys Val Ala Ala Gly Val 
        115                 120                 125             


Leu Leu Ala Ile Cys Leu Phe Trp Ala Met Ile Gly Trp Leu Ser Gln 
    130                 135                 140                 


Asp Thr Lys Ala Glu Pro Leu Asp Pro Glu Ala Asp Ser His Val Glu 
145                 150                 155                 160 


Val Phe Gly Asp Glu Pro Glu Gln Gln Leu Ser Pro Ile Phe Arg Asn 
                165                 170                 175     


Ala Ser Gly Gln Ser Trp Phe Ser Pro Pro Ala Ser Pro Phe Gly Gln 
            180                 185                 190         


Ser Ser Val Gln Thr Ile Gln Pro Lys Arg Asp Ser 
        195                 200                 


<210>  378
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Met Pro Ser Cys Asn Arg Ser Cys Ser Cys Ser Arg Gly Pro Ser 
1               5                   10                  15      


Val Glu Asp Gly Lys Trp Tyr Gly Val Arg Ser Tyr Leu His Leu Phe 
            20                  25                  30          


Tyr Glu Asp Cys Ala Gly Thr Ala Leu Ser Asp Asp Pro Glu Gly Pro 
        35                  40                  45              


Pro Val Leu Cys Pro Arg Arg Pro Trp Pro Ser Leu Cys Trp Lys Ile 
    50                  55                  60                  


Ser Leu Ser Ser Gly Thr Leu Leu Leu Leu Leu Gly Val Ala Ala Leu 
65                  70                  75                  80  


Thr Thr Gly Tyr Ala Val Pro Pro Lys Leu Glu Gly Ile Gly Glu Gly 
                85                  90                  95      


Glu Phe Leu Val Leu Asp Gln Arg Ala Ala Asp Tyr Asn Gln Ala Leu 
            100                 105                 110         


Gly Thr Cys Arg Leu Ala Gly Thr Ala Leu Cys Val Ala Ala Gly Val 
        115                 120                 125             


Leu Leu Ala Ile Cys Leu Phe Trp Ala Met Ile Gly Trp Leu Ser Gln 
    130                 135                 140                 


Asp Thr Lys Ala Glu Pro Leu Asp Pro Glu Ala Asp Ser His Val Glu 
145                 150                 155                 160 


Val Phe Gly Asp Glu Pro Glu Gln Gln Leu Ser Pro Ile Phe Arg Asn 
                165                 170                 175     


Ala Ser Gly Gln Ser Trp Phe Ser Pro Pro Ala Ser Pro Phe Gly Gln 
            180                 185                 190         


Ser Ser Val Gln Thr Ile Gln Pro Lys Arg Asp Ser 
        195                 200                 


<210>  379
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  379

Met Met Pro Ser Cys Asn Arg Ser Cys Ser Cys Ser Arg Gly Pro Ser 
1               5                   10                  15      


Val Glu Asp Gly Lys Trp Tyr Gly Val Arg Ser Tyr Leu His Leu Phe 
            20                  25                  30          


Tyr Glu Asp Cys Ala Gly Thr Ala Leu Ser Asp Asp Pro Glu Gly Pro 
        35                  40                  45              


Pro Val Leu Cys Pro Arg Arg Pro Trp Pro Ser Leu Cys Trp Lys Ile 
    50                  55                  60                  


Ser Leu Ser Ser Gly Thr Leu Leu Leu Leu Leu Gly Val Ala Ala Leu 
65                  70                  75                  80  


Thr Thr Gly Tyr Ala Val Pro Pro Lys Leu Glu Gly Ile Gly Glu Gly 
                85                  90                  95      


Glu Phe Leu Val Leu Asp Gln Arg Ala Ala Asp Tyr Asn Gln Ala Leu 
            100                 105                 110         


Gly Thr Cys Arg Leu Ala Gly Thr Ala Leu Cys Val Ala Ala Gly Val 
        115                 120                 125             


Leu Leu Ala Ile Cys Leu Phe Trp Ala Met Ile Gly Trp Leu Ser Gln 
    130                 135                 140                 


Asp Thr Lys Ala Glu Pro Leu Asp Pro Glu Ala Asp Ser His Val Glu 
145                 150                 155                 160 


Val Phe Gly Asp Glu Pro Glu Gln Gln Leu Ser Pro Ile Phe Arg Asn 
                165                 170                 175     


Ala Ser Gly Gln Ser Trp Phe Ser Pro Pro Ala Ser Pro Phe Gly Gln 
            180                 185                 190         


Ser Ser Val Gln Thr Ile Gln Pro Lys Arg Asp Ser 
        195                 200                 


<210>  380
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  380

Met Met Pro Ser Cys Asn Arg Ser Cys Ser Cys Ser Arg Gly Pro Ser 
1               5                   10                  15      


Val Glu Asp Gly Lys Trp Tyr Gly Val Arg Ser Tyr Leu His Leu Phe 
            20                  25                  30          


Tyr Glu Asp Cys Ala Gly Thr Ala Leu Ser Asp Asp Pro Glu Gly Pro 
        35                  40                  45              


Pro Val Leu Cys Pro Arg Arg Pro Trp Pro Ser Leu Cys Trp Lys Ile 
    50                  55                  60                  


Ser Leu Ser Ser Gly Thr Leu Leu Leu Leu Leu Gly Val Ala Ala Leu 
65                  70                  75                  80  


Thr Thr Gly Tyr Ala Val Pro Pro Lys Leu Glu Gly Ile Gly Glu Gly 
                85                  90                  95      


Glu Phe Leu Val Leu Asp Gln Arg Ala Ala Asp Tyr Asn Gln Ala Leu 
            100                 105                 110         


Gly Thr Cys Arg Leu Ala Gly Thr Ala Leu Cys Val Ala Ala Gly Val 
        115                 120                 125             


Leu Leu Ala Ile Cys Leu Phe Trp Ala Met Ile Gly Trp Leu Ser Gln 
    130                 135                 140                 


Asp Thr Lys Ala Glu Pro Leu Asp Pro Glu Ala Asp Ser His Val Glu 
145                 150                 155                 160 


Val Phe Gly Asp Glu Pro Glu Gln Gln Leu Ser Pro Ile Phe Arg Asn 
                165                 170                 175     


Ala Ser Gly Gln Ser Trp Phe Ser Pro Pro Ala Ser Pro Phe Gly Gln 
            180                 185                 190         


Ser Ser Val Gln Thr Ile Gln Pro Lys Arg Asp Ser 
        195                 200                 


<210>  381
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  381

Met Met Pro Ser Cys Asn Arg Ser Cys Ser Cys Ser Arg Gly Pro Ser 
1               5                   10                  15      


Val Glu Asp Gly Lys Trp Tyr Gly Val Arg Ser Tyr Leu His Leu Phe 
            20                  25                  30          


Tyr Glu Asp Cys Ala Gly Thr Ala Leu Ser Asp Asp Pro Glu Gly Pro 
        35                  40                  45              


Pro Val Leu Cys Pro Arg Arg Pro Trp Pro Ser Leu Cys Trp Lys Ile 
    50                  55                  60                  


Ser Leu Ser Ser Gly Thr Leu Leu Leu Leu Leu Gly Val Ala Ala Leu 
65                  70                  75                  80  


Thr Thr Gly Tyr Ala Val Pro Pro Lys Leu Glu Gly Ile Gly Glu Gly 
                85                  90                  95      


Glu Phe Leu Val Leu Asp Gln Arg Ala Ala Asp Tyr Asn Gln Ala Leu 
            100                 105                 110         


Gly Thr Cys Arg Leu Ala Gly Thr Ala Leu Cys Val Ala Ala Gly Val 
        115                 120                 125             


Leu Leu Ala Ile Cys Leu Phe Trp Ala Met Ile Gly Trp Leu Ser Gln 
    130                 135                 140                 


Asp Thr Lys Ala Glu Pro Leu Asp Pro Glu Ala Asp Ser His Val Glu 
145                 150                 155                 160 


Val Phe Gly Asp Glu Pro Glu Gln Gln Leu Ser Pro Ile Phe Arg Asn 
                165                 170                 175     


Ala Ser Gly Gln Ser Trp Phe Ser Pro Pro Ala Ser Pro Phe Gly Gln 
            180                 185                 190         


Ser Ser Val Gln Thr Ile Gln Pro Lys Arg Asp Ser 
        195                 200                 


<210>  382
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Met Pro Ser Cys Asn Arg Ser Cys Ser Cys Ser Arg Gly Pro Ser 
1               5                   10                  15      


Val Glu Asp Gly Lys Trp Tyr Gly Val Arg Ser Tyr Leu His Leu Phe 
            20                  25                  30          


Tyr Glu Asp Cys Ala Gly Thr Ala Leu Ser Asp Asp Pro Glu Gly Pro 
        35                  40                  45              


Pro Val Leu Cys Pro Arg Arg Pro Trp Pro Ser Leu Cys Trp Lys Ile 
    50                  55                  60                  


Ser Leu Ser Ser Gly Thr Leu Leu Leu Leu Leu Gly Val Ala Ala Leu 
65                  70                  75                  80  


Thr Thr Gly Tyr Ala Val Pro Pro Lys Leu Glu Gly Ile Gly Glu Gly 
                85                  90                  95      


Glu Phe Leu Val Leu Asp Gln Arg Ala Ala Asp Tyr Asn Gln Ala Leu 
            100                 105                 110         


Gly Thr Cys Arg Leu Ala Gly Thr Ala Leu Cys Val Ala Ala Gly Val 
        115                 120                 125             


Leu Leu Ala Ile Cys Leu Phe Trp Ala Met Ile Gly Trp Leu Ser Gln 
    130                 135                 140                 


Asp Thr Lys Ala Glu Pro Leu Asp Pro Glu Ala Asp Ser His Val Glu 
145                 150                 155                 160 


Val Phe Gly Asp Glu Pro Glu Gln Gln Leu Ser Pro Ile Phe Arg Asn 
                165                 170                 175     


Ala Ser Gly Gln Ser Trp Phe Ser Pro Pro Ala Ser Pro Phe Gly Gln 
            180                 185                 190         


Ser Ser Val Gln Thr Ile Gln Pro Lys Arg Asp Ser 
        195                 200                 


<210>  383
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  383

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Phe Val Leu Phe His Lys Ile Pro Leu Asp Gly 
465                 470                 475         


<210>  384
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  384

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
                485                 490                 495     


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
        515                 520                 525             


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
                565                 570                 575     


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
        595                 600                 605             


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
625                 630                 635                 640 


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
                645                 650                 655     


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
            660                 665                 670         


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
        675                 680                 685             


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
    690                 695                 700                 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
705                 710                 715                 720 


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
                725                 730                 735     


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
            740                 745                 750         


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
        755                 760                 765             


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
    770                 775                 780                 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
785                 790                 795                 800 


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
                805                 810                 815     


Tyr Leu Asp Ile Leu Gly 
            820         


<210>  385
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  385

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Asp Phe Ser Trp Phe Gly Phe Gly Lys Val Lys Ser Arg Gln Gly 
465                 470                 475                 480 


Val Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
                485                 490                 495     


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
            500                 505                 510         


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
        515                 520                 525             


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
    530                 535                 540                 


Trp Pro Arg Gly Ser Pro Lys Thr Ala 
545                 550             


<210>  386
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  386

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
                485                 490                 495     


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
        515                 520                 525             


Trp Pro Arg Gly Ser Pro Lys Thr Ala 
    530                 535         


<210>  387
<211>  838
<212>  PRT
<213>  Homo sapiens

<400>  387

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Asp Phe Ser Trp Phe Gly Phe Gly Lys Val Lys Ser Arg Gln Gly 
465                 470                 475                 480 


Val Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
                485                 490                 495     


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
            500                 505                 510         


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
        515                 520                 525             


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
    530                 535                 540                 


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
545                 550                 555                 560 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
                565                 570                 575     


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
            580                 585                 590         


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
        595                 600                 605             


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
    610                 615                 620                 


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
625                 630                 635                 640 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
                645                 650                 655     


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
            660                 665                 670         


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
        675                 680                 685             


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
    690                 695                 700                 


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
705                 710                 715                 720 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
                725                 730                 735     


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
            740                 745                 750         


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
        755                 760                 765             


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
    770                 775                 780                 


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
785                 790                 795                 800 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
                805                 810                 815     


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
            820                 825                 830         


Tyr Leu Asp Ile Leu Gly 
        835             


<210>  388
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  388

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575     


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605             


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640 


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655     


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670         


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685             


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700                 


Tyr Ser Thr Asp Tyr Tyr Arg Leu Phe Asn Pro Ser Gly Asn Asp Phe 
705                 710                 715                 720 


Cys Ile Trp Cys Glu Val Gly Gly His Thr Met Leu Pro Ile Arg Trp 
                725                 730                 735     


Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp 
            740                 745                 750         


Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr Gly Lys 
        755                 760                 765             


Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys Ile Thr 
    770                 775                 780                 


Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu Val Tyr 
785                 790                 795                 800 


Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg Leu Asn 
                805                 810                 815     


Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala Thr Pro 
            820                 825                 830         


Ile Tyr Leu Asp Ile Leu Gly 
        835                 


<210>  389
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  389

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Cys Phe Arg Glu Ile Met Leu Asn Pro Ile Ser Leu Pro Gly His Ser 
    530                 535                 540                 


Lys Pro Leu Asn His Gly Ile Tyr Val Glu Asp Val Asn Val Tyr Phe 
545                 550                 555                 560 


Ser Lys Gly Arg His Gly Phe 
                565         


<210>  390
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  390

Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn Ser Gly 
1               5                   10                  15      


Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His Leu Arg 
            20                  25                  30          


Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp Gln Leu 
        35                  40                  45              


Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn Phe Phe 
    50                  55                  60                  


Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu Gln Gly 
65                  70                  75                  80  


Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala Asp Gly 
                85                  90                  95      


Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp Leu Pro 
            100                 105                 110         


Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly Asp Asn 
        115                 120                 125             


Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp Val Asp 
    130                 135                 140                 


Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr Asn Leu 
145                 150                 155                 160 


Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn Val Thr 
                165                 170                 175     


Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn Val Val 
            180                 185                 190         


Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro Pro Arg 
        195                 200                 205             


Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys Ile Glu 
    210                 215                 220                 


Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu His Asn 
225                 230                 235                 240 


Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr Tyr Gln 
                245                 250                 255     


Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro Thr His 
            260                 265                 270         


Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu Gly Thr 
        275                 280                 285             


Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe Pro Glu 
    290                 295                 300                 


Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr Pro Pro 
305                 310                 315                 320 


Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val Ser Ile 
                325                 330                 335     


Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val Leu Phe 
            340                 345                 350         


Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met Lys Gly 
        355                 360                 365             


Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro Leu His 
    370                 375                 380                 


His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala Gly Pro 
385                 390                 395                 400 


Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu Asn Pro 
                405                 410                 415     


Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr Tyr Val 
            420                 425                 430         


Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu Gly Glu 
        435                 440                 445             


Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu Ser Pro 
    450                 455                 460                 


Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp Pro Thr 
465                 470                 475                 480 


Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr Asn 
                485                 490                 495     


Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly Asp Gly 
            500                 505                 510         


Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp Leu Asn 
        515                 520                 525             


Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val Asp Gly 
    530                 535                 540                 


Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met Leu His 
545                 550                 555                 560 


Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser Gln His 
                565                 570                 575     


Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Ala Asn 
            580                 585                 590         


Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser 
        595                 600                 605             


Thr Asp Tyr Tyr Arg Val Val Gln Ala 
    610                 615         


<210>  391
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  391

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575     


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605             


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640 


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655     


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670         


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685             


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700                 


Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile 
705                 710                 715                 720 


Arg Trp Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu 
                725                 730                 735     


Ser Asp Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr 
            740                 745                 750         


Gly Lys Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys 
        755                 760                 765             


Ile Thr Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu 
    770                 775                 780                 


Val Tyr Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg 
785                 790                 795                 800 


Leu Asn Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala 
                805                 810                 815     


Thr Pro Ile Tyr Leu Asp Ile Leu Gly 
            820                 825 


<210>  392
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  392

Met Ala Arg Arg Phe Gln Glu Glu Leu Ala Ala Phe Leu Phe Glu Tyr 
1               5                   10                  15      


Asp Thr Pro Arg Met Val Leu Val Arg Asn Lys Lys Val Gly Val Ile 
            20                  25                  30          


Phe Arg Leu Ile Gln Leu Val Val Leu Val Tyr Val Ile Gly Trp Val 
        35                  40                  45              


Phe Leu Tyr Glu Lys Gly Tyr Gln Thr Ser Ser Gly Leu Ile Ser Ser 
    50                  55                  60                  


Val Ser Val Lys Leu Lys Gly Leu Ala Val Thr Gln Leu Pro Gly Leu 
65                  70                  75                  80  


Gly Pro Gln Val Trp Asp Val Ala Asp Tyr Val Phe Pro Ala Gln Gly 
                85                  90                  95      


Asp Asn Ser Phe Val Val Met Thr Asn Phe Ile Val Thr Pro Lys Gln 
            100                 105                 110         


Thr Gln Gly Tyr Cys Ala Glu His Pro Glu Gly Gly Ile Cys Lys Glu 
        115                 120                 125             


Asp Ser Gly Cys Thr Pro Gly Lys Ala Lys Arg Lys Ala Gln Gly Ile 
    130                 135                 140                 


Arg Thr Gly Lys Cys Val Ala Phe Asn Asp Thr Val Lys Thr Cys Glu 
145                 150                 155                 160 


Ile Phe Gly Trp Cys Pro Val Glu Val Asp Asp Asp Ile Pro Arg Pro 
                165                 170                 175     


Ala Leu Leu Arg Glu Ala Glu Asn Phe Thr Leu Phe Ile Lys Asn Ser 
            180                 185                 190         


Ile Ser Phe Pro Arg Phe Lys Val Asn Arg Arg Asn Leu Val Glu Glu 
        195                 200                 205             


Val Asn Ala Ala His Met Lys Thr Cys Leu Phe His Lys Thr Leu His 
    210                 215                 220                 


Pro Leu Cys Pro Val Phe Gln Leu Gly Tyr Val Val Gln Glu Ser Gly 
225                 230                 235                 240 


Gln Asn Phe Ser Thr Leu Ala Glu Lys Gly Gly Val Val Gly Ile Thr 
                245                 250                 255     


Ile Asp Trp His Cys Asp Leu Asp Trp His Val Arg His Cys Arg Pro 
            260                 265                 270         


Ile Tyr Glu Phe His Gly Leu Tyr Glu Glu Lys Asn Leu Ser Pro Gly 
        275                 280                 285             


Phe Asn Phe Arg Phe Ala Arg His Phe Val Glu Asn Gly Thr Asn Tyr 
    290                 295                 300                 


Arg His Leu Phe Lys Val Phe Gly Ile Arg Phe Asp Ile Leu Val Asp 
305                 310                 315                 320 


Gly Lys Ala Gly Lys Phe Asp Ile Ile Pro Thr Met Thr Thr Ile Gly 
                325                 330                 335     


Ser Gly Ile Gly Ile Phe Gly Val Ala Thr Val Leu Cys Asp Leu Leu 
            340                 345                 350         


Leu Leu His Ile Leu Pro Lys Arg His Tyr Tyr Lys Gln Lys Lys Phe 
        355                 360                 365             


Lys Tyr Ala Glu Asp Met Gly Pro Gly Ala Ala Glu Arg Asp Leu Ala 
    370                 375                 380                 


Ala Thr Ser Ser Thr Leu Gly Leu Gln Glu Asn Met Arg Thr Ser 
385                 390                 395                 


<210>  393
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  393

Met Pro Arg Arg Leu Gln Pro Arg Gly Ala Gly Thr Lys Gly Pro Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Ala Ser Gly Ala Ala Arg Asn Ser His Ser Ala 
            20                  25                  30          


Ala Ser Arg Asp Pro Pro Ala Ser Ala Lys Pro Leu Leu Arg Trp Asp 
        35                  40                  45              


Glu Val Pro Asp Asp Phe Val Glu Cys Phe Ile Leu Ser Gly Tyr Arg 
    50                  55                  60                  


Arg Leu Pro Cys Thr Ala Gln Glu Cys Leu Ala Ser Val Leu Lys Pro 
65                  70                  75                  80  


Thr Asn Glu Thr Leu Asn Phe Trp Thr His Phe Ile Pro Leu Leu Leu 
                85                  90                  95      


Phe Leu Ser Lys Phe Cys Arg Leu Phe Phe Leu Ser Gly Gly Asp Val 
            100                 105                 110         


Pro Phe His His Pro Trp Leu Leu Pro Leu Trp Cys Tyr Ala Ser Gly 
        115                 120                 125             


Val Leu Leu Thr Phe Ala Met Ser Cys Thr Ala His Val Phe Ser Cys 
    130                 135                 140                 


Leu Ser Leu Arg Leu Arg Ala Ala Phe Phe Tyr Leu Asp Tyr Ala Ser 
145                 150                 155                 160 


Ile Ser Tyr Tyr Gly Phe Gly Ser Thr Val Ala Tyr Tyr Tyr Tyr Leu 
                165                 170                 175     


Leu Pro Gly Leu Ser Leu Leu Asp Ala Arg Val Met Thr Pro Tyr Leu 
            180                 185                 190         


Gln Gln Arg Leu Gly Trp His Val Asp Cys Thr Arg Leu Ile Ala Ala 
        195                 200                 205             


Tyr Arg Ala Leu Val Leu Pro Val Ala Phe Val Leu Ala Val Ala Cys 
    210                 215                 220                 


Thr Val Ala Cys Cys Lys Ser Arg Thr Asp Trp Cys Thr Tyr Pro Phe 
225                 230                 235                 240 


Ala Leu Arg Thr Phe Val Phe Val Met Pro Leu Ser Met Ala Cys Pro 
                245                 250                 255     


Ile Met Leu Glu Ser Trp Leu Phe Asp Leu Arg Gly Glu Asn Pro Thr 
            260                 265                 270         


Leu Phe Val His Phe Tyr Arg Arg Tyr Phe Trp Leu Val Val Ala Ala 
        275                 280                 285             


Phe Phe Asn Val Ser Lys Ile Pro Glu Arg Ile Gln Pro Gly Leu Phe 
    290                 295                 300                 


Asp Ile Ile Gly His Ser His Gln Leu Phe His Ile Phe Thr Phe Leu 
305                 310                 315                 320 


Ser Ile Tyr Asp Gln Val Tyr Tyr Val Glu Glu Gly Leu Arg Gln Phe 
                325                 330                 335     


Leu Gln Ala Pro Pro Ala Ala Pro Thr Phe Ser Gly Thr Val Gly Tyr 
            340                 345                 350         


Met Leu Leu Leu Val Val Cys Leu Gly Leu Val Ile Arg Lys Phe Leu 
        355                 360                 365             


Asn Ser Ser Glu Phe Cys Ser Lys Lys 
    370                 375         


<210>  394
<211>  1195
<212>  PRT
<213>  Homo sapiens

<400>  394

Met Asp Leu Arg Asp Phe Tyr Leu Leu Ala Ala Leu Ile Ala Cys Leu 
1               5                   10                  15      


Arg Leu Asp Ser Ala Ile Ala Gln Glu Leu Ile Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Leu Pro Glu Asn Val Pro Ile Gly Asn Ile Pro Lys Asp Leu Asn 
        35                  40                  45              


Ile Ser His Ile Asn Ala Ala Thr Gly Thr Ser Ala Ser Leu Val Tyr 
    50                  55                  60                  


Arg Leu Val Ser Lys Ala Gly Asp Ala Pro Leu Val Lys Val Ser Ser 
65                  70                  75                  80  


Ser Thr Gly Glu Ile Phe Thr Thr Ser Asn Arg Ile Asp Arg Glu Lys 
                85                  90                  95      


Leu Cys Ala Gly Ala Ser Tyr Ala Glu Glu Asn Glu Cys Phe Phe Glu 
            100                 105                 110         


Leu Glu Val Val Ile Leu Pro Asn Asp Phe Phe Arg Leu Ile Lys Ile 
        115                 120                 125             


Lys Ile Ile Val Lys Asp Thr Asn Asp Asn Ala Pro Met Phe Pro Ser 
    130                 135                 140                 


Pro Val Ile Asn Ile Ser Ile Pro Glu Asn Thr Leu Ile Asn Ser Arg 
145                 150                 155                 160 


Phe Pro Ile Pro Ser Ala Thr Asp Pro Asp Thr Gly Phe Asn Gly Val 
                165                 170                 175     


Gln His Tyr Glu Leu Leu Asn Gly Gln Ser Val Phe Gly Leu Asp Ile 
            180                 185                 190         


Val Glu Thr Pro Glu Gly Glu Lys Trp Pro Gln Leu Ile Val Gln Gln 
        195                 200                 205             


Asn Leu Asp Arg Glu Gln Lys Asp Thr Tyr Val Met Lys Ile Lys Val 
    210                 215                 220                 


Glu Asp Gly Gly Thr Pro Gln Lys Ser Ser Thr Ala Ile Leu Gln Val 
225                 230                 235                 240 


Thr Val Ser Asp Val Asn Asp Asn Arg Pro Val Phe Lys Glu Gly Gln 
                245                 250                 255     


Val Glu Val His Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Ile 
            260                 265                 270         


Gln Leu His Ala Thr Asp Ala Asp Ile Gly Ser Asn Ala Glu Ile Arg 
        275                 280                 285             


Tyr Ile Phe Gly Ala Gln Val Ala Pro Ala Thr Lys Arg Leu Phe Ala 
    290                 295                 300                 


Leu Asn Asn Thr Thr Gly Leu Ile Thr Val Gln Arg Ser Leu Asp Arg 
305                 310                 315                 320 


Glu Glu Thr Ala Ile His Lys Val Thr Val Leu Ala Ser Asp Gly Ser 
                325                 330                 335     


Ser Thr Pro Ala Arg Ala Thr Val Thr Ile Asn Val Thr Asp Val Asn 
            340                 345                 350         


Asp Asn Pro Pro Asn Ile Asp Leu Arg Tyr Ile Ile Ser Pro Ile Asn 
        355                 360                 365             


Gly Thr Val Tyr Leu Ser Glu Lys Asp Pro Val Asn Thr Lys Ile Ala 
    370                 375                 380                 


Leu Ile Thr Val Ser Asp Lys Asp Thr Asp Val Asn Gly Lys Val Ile 
385                 390                 395                 400 


Cys Phe Ile Glu Arg Glu Val Pro Phe His Leu Lys Ala Val Tyr Asp 
                405                 410                 415     


Asn Gln Tyr Leu Leu Glu Thr Ser Ser Leu Leu Asp Tyr Glu Gly Thr 
            420                 425                 430         


Lys Glu Phe Ser Phe Lys Ile Val Ala Ser Asp Ser Gly Lys Pro Ser 
        435                 440                 445             


Leu Asn Gln Thr Ala Leu Val Arg Val Lys Leu Glu Asp Glu Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ile Phe Asn Gln Pro Val Ile Glu Leu Ser Val Ser Glu 
465                 470                 475                 480 


Asn Asn Arg Arg Gly Leu Tyr Leu Thr Thr Ile Ser Ala Thr Asp Glu 
                485                 490                 495     


Asp Ser Gly Lys Asn Ala Asp Ile Val Tyr Gln Leu Gly Pro Asn Ala 
            500                 505                 510         


Ser Phe Phe Asp Leu Asp Arg Lys Thr Gly Val Leu Thr Ala Ser Arg 
        515                 520                 525             


Val Phe Asp Arg Glu Glu Gln Glu Arg Phe Ile Phe Thr Val Thr Ala 
    530                 535                 540                 


Arg Asp Asn Gly Thr Pro Pro Leu Gln Ser Gln Ala Ala Val Ile Val 
545                 550                 555                 560 


Thr Val Leu Asp Glu Asn Asp Asn Ser Pro Lys Phe Thr His Asn His 
                565                 570                 575     


Phe Gln Phe Phe Val Ser Glu Asn Leu Pro Lys Tyr Ser Thr Val Gly 
            580                 585                 590         


Val Ile Thr Val Thr Asp Ala Asp Ala Gly Glu Asn Lys Ala Val Thr 
        595                 600                 605             


Leu Ser Ile Leu Asn Asp Asn Asp Asn Phe Val Leu Asp Pro Tyr Ser 
    610                 615                 620                 


Gly Val Ile Lys Ser Asn Val Ser Phe Asp Arg Glu Gln Gln Ser Ser 
625                 630                 635                 640 


Tyr Thr Phe Asp Val Lys Ala Thr Asp Gly Gly Gln Pro Pro Arg Ser 
                645                 650                 655     


Ser Thr Ala Lys Val Thr Ile Asn Val Met Asp Val Asn Asp Asn Ser 
            660                 665                 670         


Pro Val Val Ile Ser Pro Pro Ser Asn Thr Ser Phe Lys Leu Val Pro 
        675                 680                 685             


Leu Ser Ala Ile Pro Gly Ser Val Val Ala Glu Val Phe Ala Val Asp 
    690                 695                 700                 


Val Asp Thr Gly Met Asn Ala Glu Leu Lys Tyr Thr Ile Val Ser Gly 
705                 710                 715                 720 


Asn Asn Lys Gly Leu Phe Arg Ile Asp Pro Val Thr Gly Asn Ile Thr 
                725                 730                 735     


Leu Glu Glu Lys Pro Ala Pro Thr Asp Val Gly Leu His Arg Leu Val 
            740                 745                 750         


Val Asn Ile Ser Asp Leu Gly Tyr Pro Lys Ser Leu His Thr Leu Val 
        755                 760                 765             


Leu Val Phe Leu Tyr Val Asn Asp Thr Ala Gly Asn Ala Ser Tyr Ile 
    770                 775                 780                 


Tyr Asp Leu Ile Arg Arg Thr Met Glu Thr Pro Leu Asp Arg Asn Ile 
785                 790                 795                 800 


Gly Asp Ser Ser Gln Pro Tyr Gln Asn Glu Asp Tyr Leu Thr Ile Met 
                805                 810                 815     


Ile Ala Ile Ile Ala Gly Ala Met Val Val Ile Val Val Ile Phe Val 
            820                 825                 830         


Thr Val Leu Val Arg Cys Arg His Ala Ser Arg Phe Lys Ala Ala Gln 
        835                 840                 845             


Arg Ser Lys Gln Gly Ala Glu Trp Met Ser Pro Asn Gln Glu Asn Lys 
    850                 855                 860                 


Gln Asn Lys Lys Lys Lys Arg Lys Lys Arg Lys Ser Pro Lys Ser Ser 
865                 870                 875                 880 


Leu Leu Asn Phe Val Thr Ile Glu Glu Ser Lys Pro Asp Asp Ala Val 
                885                 890                 895     


His Glu Pro Ile Asn Gly Thr Ile Ser Leu Pro Ala Glu Leu Glu Glu 
            900                 905                 910         


Gln Ser Ile Gly Arg Phe Asp Trp Gly Pro Ala Pro Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asn Ser Pro Asp Leu Ala Lys His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe His Leu Lys Pro Asp Thr Pro Val Ser Val Lys Lys 
945                 950                 955                 960 


His His Val Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Gly Gly 
                965                 970                 975     


Cys Asp Thr Leu Ser Lys Arg Ser Ser Thr Ser Ser Asp His Phe Ser 
            980                 985                 990         


Ala Ser Glu Cys Ser Ser Gln Gly  Gly Phe Lys Thr Lys  Gly Pro Leu 
        995                 1000                 1005             


His Thr  Arg Gln Cys Asn Ser  His Ser Lys Ser Asp  Asn Ile Pro 
    1010                 1015                 1020             


Val Thr  Pro Gln Lys Cys Pro  Ser Ser Thr Gly Phe  His Ile Gln 
    1025                 1030                 1035             


Glu Asn  Glu Glu Ser His Tyr  Glu Pro Gln Asp Glu  Phe Tyr Asp 
    1040                 1045                 1050             


Gln Ala  Ser Pro Asp Lys Arg  Thr Glu Ala Asp Gly  Asn Ser Asp 
    1055                 1060                 1065             


Pro Asn  Ser Asp Gly Pro Leu  Gly Pro Arg Gly Leu  Ala Glu Ala 
    1070                 1075                 1080             


Thr Glu  Met Cys Thr Gln Glu  Cys Leu Val Leu Gly  His Ser Asp 
    1085                 1090                 1095             


Asn Cys  Trp Met Pro Pro Gly  Leu Gly Pro Tyr Gln  His Pro Lys 
    1100                 1105                 1110             


Ser Pro  Leu Ser Thr Phe Ala  Pro Gln Lys Glu Trp  Val Lys Lys 
    1115                 1120                 1125             


Asp Lys  Leu Val Asn Gly His  Thr Leu Thr Arg Ala  Trp Lys Glu 
    1130                 1135                 1140             


Asp Ser  Asn Arg Asn Gln Phe  Asn Asp Arg Lys Gln  Tyr Gly Ser 
    1145                 1150                 1155             


Asn Glu  Gly His Phe Asn Asn  Gly Ser His Met Thr  Asp Ile Pro 
    1160                 1165                 1170             


Leu Ala  Asn Leu Lys Ser Tyr  Lys Gln Ala Gly Gly  Ala Thr Glu 
    1175                 1180                 1185             


Ser Pro  Lys Glu His Gln Leu  
    1190                 1195 


<210>  395
<211>  1161
<212>  PRT
<213>  Homo sapiens

<400>  395

Met Asp Leu Arg Asp Phe Tyr Leu Leu Ala Ala Leu Ile Ala Cys Leu 
1               5                   10                  15      


Arg Leu Asp Ser Ala Ile Ala Gln Glu Leu Ile Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Leu Pro Glu Asn Val Pro Ile Gly Asn Ile Pro Lys Asp Leu Asn 
        35                  40                  45              


Ile Ser His Ile Asn Ala Ala Thr Gly Thr Ser Ala Ser Leu Val Tyr 
    50                  55                  60                  


Arg Leu Val Ser Lys Ala Gly Asp Ala Pro Leu Val Lys Val Ser Ser 
65                  70                  75                  80  


Ser Thr Gly Glu Ile Phe Thr Thr Ser Asn Arg Ile Asp Arg Glu Lys 
                85                  90                  95      


Leu Cys Ala Gly Ala Ser Tyr Ala Glu Glu Asn Glu Cys Phe Phe Glu 
            100                 105                 110         


Leu Glu Val Val Ile Leu Pro Asn Asp Phe Phe Arg Leu Ile Lys Ile 
        115                 120                 125             


Lys Ile Ile Val Lys Asp Thr Asn Asp Asn Ala Pro Met Phe Pro Ser 
    130                 135                 140                 


Pro Val Ile Asn Ile Ser Ile Pro Glu Asn Thr Leu Ile Asn Ser Arg 
145                 150                 155                 160 


Phe Pro Ile Pro Ser Ala Thr Asp Pro Asp Thr Gly Phe Asn Gly Val 
                165                 170                 175     


Gln His Tyr Glu Leu Leu Asn Gly Gln Ser Val Phe Gly Leu Asp Ile 
            180                 185                 190         


Val Glu Thr Pro Glu Gly Glu Lys Trp Pro Gln Leu Ile Val Gln Gln 
        195                 200                 205             


Asn Leu Asp Arg Glu Gln Lys Asp Thr Tyr Val Met Lys Ile Lys Val 
    210                 215                 220                 


Glu Asp Gly Gly Thr Pro Gln Lys Ser Ser Thr Ala Ile Leu Gln Val 
225                 230                 235                 240 


Thr Val Ser Asp Val Asn Asp Asn Arg Pro Val Phe Lys Glu Gly Gln 
                245                 250                 255     


Val Glu Val His Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Ile 
            260                 265                 270         


Gln Leu His Ala Thr Asp Ala Asp Ile Gly Ser Asn Ala Glu Ile Arg 
        275                 280                 285             


Tyr Ile Phe Gly Ala Gln Val Ala Pro Ala Thr Lys Arg Leu Phe Ala 
    290                 295                 300                 


Leu Asn Asn Thr Thr Gly Leu Ile Thr Val Gln Arg Ser Leu Asp Arg 
305                 310                 315                 320 


Glu Glu Thr Ala Ile His Lys Val Thr Val Leu Ala Ser Asp Gly Ser 
                325                 330                 335     


Ser Thr Pro Ala Arg Ala Thr Val Thr Ile Asn Val Thr Asp Val Asn 
            340                 345                 350         


Asp Asn Pro Pro Asn Ile Asp Leu Arg Tyr Ile Ile Ser Pro Ile Asn 
        355                 360                 365             


Gly Thr Val Tyr Leu Ser Glu Lys Asp Pro Val Asn Thr Lys Ile Ala 
    370                 375                 380                 


Leu Ile Thr Val Ser Asp Lys Asp Thr Asp Val Asn Gly Lys Val Ile 
385                 390                 395                 400 


Cys Phe Ile Glu Arg Glu Val Pro Phe His Leu Lys Ala Val Tyr Asp 
                405                 410                 415     


Asn Gln Tyr Leu Leu Glu Thr Ser Ser Leu Leu Asp Tyr Glu Gly Thr 
            420                 425                 430         


Lys Glu Phe Ser Phe Lys Ile Val Ala Ser Asp Ser Gly Lys Pro Ser 
        435                 440                 445             


Leu Asn Gln Thr Ala Leu Val Arg Val Lys Leu Glu Asp Glu Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ile Phe Asn Gln Pro Val Ile Glu Leu Ser Val Ser Glu 
465                 470                 475                 480 


Asn Asn Arg Arg Gly Leu Tyr Leu Thr Thr Ile Ser Ala Thr Asp Glu 
                485                 490                 495     


Asp Ser Gly Lys Asn Ala Asp Ile Val Tyr Gln Leu Gly Pro Asn Ala 
            500                 505                 510         


Ser Phe Phe Asp Leu Asp Arg Lys Thr Gly Val Leu Thr Ala Ser Arg 
        515                 520                 525             


Val Phe Asp Arg Glu Glu Gln Glu Arg Phe Ile Phe Thr Val Thr Ala 
    530                 535                 540                 


Arg Asp Asn Gly Thr Pro Pro Leu Gln Ser Gln Ala Ala Val Ile Val 
545                 550                 555                 560 


Thr Val Leu Asp Glu Asn Asp Asn Ser Pro Lys Phe Thr His Asn His 
                565                 570                 575     


Phe Gln Phe Phe Val Ser Glu Asn Leu Pro Lys Tyr Ser Thr Val Gly 
            580                 585                 590         


Val Ile Thr Val Thr Asp Ala Asp Ala Gly Glu Asn Lys Ala Val Thr 
        595                 600                 605             


Leu Ser Ile Leu Asn Asp Asn Asp Asn Phe Val Leu Asp Pro Tyr Ser 
    610                 615                 620                 


Gly Val Ile Lys Ser Asn Val Ser Phe Asp Arg Glu Gln Gln Ser Ser 
625                 630                 635                 640 


Tyr Thr Phe Asp Val Lys Ala Thr Asp Gly Gly Gln Pro Pro Arg Ser 
                645                 650                 655     


Ser Thr Ala Lys Val Thr Ile Asn Val Met Asp Val Asn Asp Asn Ser 
            660                 665                 670         


Pro Val Val Ile Ser Pro Pro Ser Asn Thr Ser Phe Lys Leu Val Pro 
        675                 680                 685             


Leu Ser Ala Ile Pro Gly Ser Val Val Ala Glu Val Phe Ala Val Asp 
    690                 695                 700                 


Val Asp Thr Gly Met Asn Ala Glu Leu Lys Tyr Thr Ile Val Ser Gly 
705                 710                 715                 720 


Asn Asn Lys Gly Leu Phe Arg Ile Asp Pro Val Thr Gly Asn Ile Thr 
                725                 730                 735     


Leu Glu Glu Lys Pro Ala Pro Thr Asp Val Gly Leu His Arg Leu Val 
            740                 745                 750         


Val Asn Ile Ser Asp Leu Gly Tyr Pro Lys Ser Leu His Thr Leu Val 
        755                 760                 765             


Leu Val Phe Leu Tyr Val Asn Asp Thr Ala Gly Asn Ala Ser Tyr Ile 
    770                 775                 780                 


Tyr Asp Leu Ile Arg Arg Thr Met Glu Thr Pro Leu Asp Arg Asn Ile 
785                 790                 795                 800 


Gly Asp Ser Ser Gln Pro Tyr Gln Asn Glu Asp Tyr Leu Thr Ile Met 
                805                 810                 815     


Ile Ala Ile Ile Ala Gly Ala Met Val Val Ile Val Val Ile Phe Val 
            820                 825                 830         


Thr Val Leu Val Arg Cys Arg His Ala Ser Arg Phe Lys Ala Ala Gln 
        835                 840                 845             


Arg Ser Lys Gln Gly Ala Glu Trp Met Ser Pro Asn Gln Glu Asn Lys 
    850                 855                 860                 


Gln Asn Lys Lys Lys Lys Arg Lys Lys Arg Lys Ser Pro Lys Ser Ser 
865                 870                 875                 880 


Leu Leu Asn Phe Val Thr Ile Glu Glu Ser Lys Pro Asp Asp Ala Val 
                885                 890                 895     


His Glu Pro Ile Asn Gly Thr Ile Ser Leu Pro Ala Glu Leu Glu Glu 
            900                 905                 910         


Gln Ser Ile Gly Arg Phe Asp Trp Gly Pro Ala Pro Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asn Ser Pro Asp Leu Ala Lys His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe His Leu Lys Pro Asp Thr Pro Val Ser Val Lys Lys 
945                 950                 955                 960 


His His Val Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Gly Gly 
                965                 970                 975     


Cys Asp Thr Leu Ser Lys Arg Ser Ser Thr Ser Ser Asp His Phe Ser 
            980                 985                 990         


Ala Ser Glu Cys Ser Ser Gln Gly  Gly Phe Lys Thr Lys  Gly Pro Leu 
        995                 1000                 1005             


His Thr  Arg Gln Pro Gln Asp  Glu Phe Tyr Asp Gln  Ala Ser Pro 
    1010                 1015                 1020             


Asp Lys  Arg Thr Glu Ala Asp  Gly Asn Ser Asp Pro  Asn Ser Asp 
    1025                 1030                 1035             


Gly Pro  Leu Gly Pro Arg Gly  Leu Ala Glu Ala Thr  Glu Met Cys 
    1040                 1045                 1050             


Thr Gln  Glu Cys Leu Val Leu  Gly His Ser Asp Asn  Cys Trp Met 
    1055                 1060                 1065             


Pro Pro  Gly Leu Gly Pro Tyr  Gln His Pro Lys Ser  Pro Leu Ser 
    1070                 1075                 1080             


Thr Phe  Ala Pro Gln Lys Glu  Trp Val Lys Lys Asp  Lys Leu Val 
    1085                 1090                 1095             


Asn Gly  His Thr Leu Thr Arg  Ala Trp Lys Glu Asp  Ser Asn Arg 
    1100                 1105                 1110             


Asn Gln  Phe Asn Asp Arg Lys  Gln Tyr Gly Ser Asn  Glu Gly His 
    1115                 1120                 1125             


Phe Asn  Asn Gly Ser His Met  Thr Asp Ile Pro Leu  Ala Asn Leu 
    1130                 1135                 1140             


Lys Ser  Tyr Lys Gln Ala Gly  Gly Ala Thr Glu Ser  Pro Lys Glu 
    1145                 1150                 1155             


His Gln  Leu 
    1160     


<210>  396
<211>  1203
<212>  PRT
<213>  Homo sapiens

<400>  396

Met Asp Leu Arg Asp Phe Tyr Leu Leu Ala Ala Leu Ile Ala Cys Leu 
1               5                   10                  15      


Arg Leu Asp Ser Ala Ile Ala Gln Glu Leu Ile Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Leu Pro Glu Asn Val Pro Ile Gly Asn Ile Pro Lys Asp Leu Asn 
        35                  40                  45              


Ile Ser His Ile Asn Ala Ala Thr Gly Thr Ser Ala Ser Leu Val Tyr 
    50                  55                  60                  


Arg Leu Val Ser Lys Ala Gly Asp Ala Pro Leu Val Lys Val Ser Ser 
65                  70                  75                  80  


Ser Thr Gly Glu Ile Phe Thr Thr Ser Asn Arg Ile Asp Arg Glu Lys 
                85                  90                  95      


Leu Cys Ala Gly Ala Ser Tyr Ala Glu Glu Asn Glu Cys Phe Phe Glu 
            100                 105                 110         


Leu Glu Val Val Ile Leu Pro Asn Asp Phe Phe Arg Leu Ile Lys Ile 
        115                 120                 125             


Lys Ile Ile Val Lys Asp Thr Asn Asp Asn Ala Pro Met Phe Pro Ser 
    130                 135                 140                 


Pro Val Ile Asn Ile Ser Ile Pro Glu Asn Thr Leu Ile Asn Ser Arg 
145                 150                 155                 160 


Phe Pro Ile Pro Ser Ala Thr Asp Pro Asp Thr Gly Phe Asn Gly Val 
                165                 170                 175     


Gln His Tyr Glu Leu Leu Asn Gly Gln Ser Val Phe Gly Leu Asp Ile 
            180                 185                 190         


Val Glu Thr Pro Glu Gly Glu Lys Trp Pro Gln Leu Ile Val Gln Gln 
        195                 200                 205             


Asn Leu Asp Arg Glu Gln Lys Asp Thr Tyr Val Met Lys Ile Lys Val 
    210                 215                 220                 


Glu Asp Gly Gly Thr Pro Gln Lys Ser Ser Thr Ala Ile Leu Gln Val 
225                 230                 235                 240 


Thr Val Ser Asp Val Asn Asp Asn Arg Pro Val Phe Lys Glu Gly Gln 
                245                 250                 255     


Val Glu Val His Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Ile 
            260                 265                 270         


Gln Leu His Ala Thr Asp Ala Asp Ile Gly Ser Asn Ala Glu Ile Arg 
        275                 280                 285             


Tyr Ile Phe Gly Ala Gln Val Ala Pro Ala Thr Lys Arg Leu Phe Ala 
    290                 295                 300                 


Leu Asn Asn Thr Thr Gly Leu Ile Thr Val Gln Arg Ser Leu Asp Arg 
305                 310                 315                 320 


Glu Glu Thr Ala Ile His Lys Val Thr Val Leu Ala Ser Asp Gly Ser 
                325                 330                 335     


Ser Thr Pro Ala Arg Ala Thr Val Thr Ile Asn Val Thr Asp Val Asn 
            340                 345                 350         


Asp Asn Pro Pro Asn Ile Asp Leu Arg Tyr Ile Ile Ser Pro Ile Asn 
        355                 360                 365             


Gly Thr Val Tyr Leu Ser Glu Lys Asp Pro Val Asn Thr Lys Ile Ala 
    370                 375                 380                 


Leu Ile Thr Val Ser Asp Lys Asp Thr Asp Val Asn Gly Lys Val Ile 
385                 390                 395                 400 


Cys Phe Ile Glu Arg Glu Val Pro Phe His Leu Lys Ala Val Tyr Asp 
                405                 410                 415     


Asn Gln Tyr Leu Leu Glu Thr Ser Ser Leu Leu Asp Tyr Glu Gly Thr 
            420                 425                 430         


Lys Glu Phe Ser Phe Lys Ile Val Ala Ser Asp Ser Gly Lys Pro Ser 
        435                 440                 445             


Leu Asn Gln Thr Ala Leu Val Arg Val Lys Leu Glu Asp Glu Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ile Phe Asn Gln Pro Val Ile Glu Leu Ser Val Ser Glu 
465                 470                 475                 480 


Asn Asn Arg Arg Gly Leu Tyr Leu Thr Thr Ile Ser Ala Thr Asp Glu 
                485                 490                 495     


Asp Ser Gly Lys Asn Ala Asp Ile Val Tyr Gln Leu Gly Pro Asn Ala 
            500                 505                 510         


Ser Phe Phe Asp Leu Asp Arg Lys Thr Gly Val Leu Thr Ala Ser Arg 
        515                 520                 525             


Val Phe Asp Arg Glu Glu Gln Glu Arg Phe Ile Phe Thr Val Thr Ala 
    530                 535                 540                 


Arg Asp Asn Gly Thr Pro Pro Leu Gln Ser Gln Ala Ala Val Ile Val 
545                 550                 555                 560 


Thr Val Leu Asp Glu Asn Asp Asn Ser Pro Lys Phe Thr His Asn His 
                565                 570                 575     


Phe Gln Phe Phe Val Ser Glu Asn Leu Pro Lys Tyr Ser Thr Val Gly 
            580                 585                 590         


Val Ile Thr Val Thr Asp Ala Asp Ala Gly Glu Asn Lys Ala Val Thr 
        595                 600                 605             


Leu Ser Ile Leu Asn Asp Asn Asp Asn Phe Val Leu Asp Pro Tyr Ser 
    610                 615                 620                 


Gly Val Ile Lys Ser Asn Val Ser Phe Asp Arg Glu Gln Gln Ser Ser 
625                 630                 635                 640 


Tyr Thr Phe Asp Val Lys Ala Thr Asp Gly Gly Gln Pro Pro Arg Ser 
                645                 650                 655     


Ser Thr Ala Lys Val Thr Ile Asn Val Met Asp Val Asn Asp Asn Ser 
            660                 665                 670         


Pro Val Val Ile Ser Pro Pro Ser Asn Thr Ser Phe Lys Leu Val Pro 
        675                 680                 685             


Leu Ser Ala Ile Pro Gly Ser Val Val Ala Glu Val Phe Ala Val Asp 
    690                 695                 700                 


Val Asp Thr Gly Met Asn Ala Glu Leu Lys Tyr Thr Ile Val Ser Gly 
705                 710                 715                 720 


Asn Asn Lys Gly Leu Phe Arg Ile Asp Pro Val Thr Gly Asn Ile Thr 
                725                 730                 735     


Leu Glu Glu Lys Pro Ala Pro Thr Asp Val Gly Leu His Arg Leu Val 
            740                 745                 750         


Val Asn Ile Ser Asp Leu Gly Tyr Pro Lys Ser Leu His Thr Leu Val 
        755                 760                 765             


Leu Val Phe Leu Tyr Val Asn Asp Thr Ala Gly Asn Ala Ser Tyr Ile 
    770                 775                 780                 


Tyr Asp Leu Ile Arg Arg Thr Met Glu Thr Pro Leu Asp Arg Asn Ile 
785                 790                 795                 800 


Gly Asp Ser Ser Gln Pro Tyr Gln Asn Glu Asp Tyr Leu Thr Ile Met 
                805                 810                 815     


Ile Ala Ile Ile Ala Gly Ala Met Val Val Ile Val Val Ile Phe Val 
            820                 825                 830         


Thr Val Leu Val Arg Cys Arg His Ala Ser Arg Phe Lys Ala Ala Gln 
        835                 840                 845             


Arg Ser Lys Gln Gly Ala Glu Trp Met Ser Pro Asn Gln Glu Asn Lys 
    850                 855                 860                 


Gln Asn Lys Lys Lys Lys Arg Lys Lys Arg Lys Ser Pro Lys Ser Ser 
865                 870                 875                 880 


Leu Leu Asn Phe Val Thr Ile Glu Glu Ser Lys Pro Asp Asp Ala Val 
                885                 890                 895     


His Glu Pro Ile Asn Gly Thr Ile Ser Leu Pro Ala Glu Leu Glu Glu 
            900                 905                 910         


Gln Ser Ile Gly Arg Phe Asp Trp Gly Pro Ala Pro Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asn Ser Pro Asp Leu Ala Lys His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe His Leu Lys Pro Asp Thr Pro Val Ser Val Lys Lys 
945                 950                 955                 960 


His His Val Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Gly Gly 
                965                 970                 975     


Cys Asp Thr Leu Ser Lys Arg Ser Ser Thr Ser Ser Asp His Phe Ser 
            980                 985                 990         


Ala Ser Glu Cys Ser Ser Gln Gly  Gly Phe Lys Thr Lys  Gly Pro Leu 
        995                 1000                 1005             


His Thr  Arg Gln Ser Gln Arg  Arg Val Thr Phe His  Leu Pro Asp 
    1010                 1015                 1020             


Gly Ser  Gln Glu Ser Cys Ser  Asp Ser Gly Leu Gly  Asp His Glu 
    1025                 1030                 1035             


Pro Val  Gly Ser Gly Thr Leu  Ile Ser His Pro Leu  Pro Leu Val 
    1040                 1045                 1050             


Gln Pro  Gln Asp Glu Phe Tyr  Asp Gln Ala Ser Pro  Asp Lys Arg 
    1055                 1060                 1065             


Thr Glu  Ala Asp Gly Asn Ser  Asp Pro Asn Ser Asp  Gly Pro Leu 
    1070                 1075                 1080             


Gly Pro  Arg Gly Leu Ala Glu  Ala Thr Glu Met Cys  Thr Gln Glu 
    1085                 1090                 1095             


Cys Leu  Val Leu Gly His Ser  Asp Asn Cys Trp Met  Pro Pro Gly 
    1100                 1105                 1110             


Leu Gly  Pro Tyr Gln His Pro  Lys Ser Pro Leu Ser  Thr Phe Ala 
    1115                 1120                 1125             


Pro Gln  Lys Glu Trp Val Lys  Lys Asp Lys Leu Val  Asn Gly His 
    1130                 1135                 1140             


Thr Leu  Thr Arg Ala Trp Lys  Glu Asp Ser Asn Arg  Asn Gln Phe 
    1145                 1150                 1155             


Asn Asp  Arg Lys Gln Tyr Gly  Ser Asn Glu Gly His  Phe Asn Asn 
    1160                 1165                 1170             


Gly Ser  His Met Thr Asp Ile  Pro Leu Ala Asn Leu  Lys Ser Tyr 
    1175                 1180                 1185             


Lys Gln  Ala Gly Gly Ala Thr  Glu Ser Pro Lys Glu  His Gln Leu 
    1190                 1195                 1200             


<210>  397
<211>  1237
<212>  PRT
<213>  Homo sapiens

<400>  397

Met Asp Leu Arg Asp Phe Tyr Leu Leu Ala Ala Leu Ile Ala Cys Leu 
1               5                   10                  15      


Arg Leu Asp Ser Ala Ile Ala Gln Glu Leu Ile Tyr Thr Ile Arg Glu 
            20                  25                  30          


Glu Leu Pro Glu Asn Val Pro Ile Gly Asn Ile Pro Lys Asp Leu Asn 
        35                  40                  45              


Ile Ser His Ile Asn Ala Ala Thr Gly Thr Ser Ala Ser Leu Val Tyr 
    50                  55                  60                  


Arg Leu Val Ser Lys Ala Gly Asp Ala Pro Leu Val Lys Val Ser Ser 
65                  70                  75                  80  


Ser Thr Gly Glu Ile Phe Thr Thr Ser Asn Arg Ile Asp Arg Glu Lys 
                85                  90                  95      


Leu Cys Ala Gly Ala Ser Tyr Ala Glu Glu Asn Glu Cys Phe Phe Glu 
            100                 105                 110         


Leu Glu Val Val Ile Leu Pro Asn Asp Phe Phe Arg Leu Ile Lys Ile 
        115                 120                 125             


Lys Ile Ile Val Lys Asp Thr Asn Asp Asn Ala Pro Met Phe Pro Ser 
    130                 135                 140                 


Pro Val Ile Asn Ile Ser Ile Pro Glu Asn Thr Leu Ile Asn Ser Arg 
145                 150                 155                 160 


Phe Pro Ile Pro Ser Ala Thr Asp Pro Asp Thr Gly Phe Asn Gly Val 
                165                 170                 175     


Gln His Tyr Glu Leu Leu Asn Gly Gln Ser Val Phe Gly Leu Asp Ile 
            180                 185                 190         


Val Glu Thr Pro Glu Gly Glu Lys Trp Pro Gln Leu Ile Val Gln Gln 
        195                 200                 205             


Asn Leu Asp Arg Glu Gln Lys Asp Thr Tyr Val Met Lys Ile Lys Val 
    210                 215                 220                 


Glu Asp Gly Gly Thr Pro Gln Lys Ser Ser Thr Ala Ile Leu Gln Val 
225                 230                 235                 240 


Thr Val Ser Asp Val Asn Asp Asn Arg Pro Val Phe Lys Glu Gly Gln 
                245                 250                 255     


Val Glu Val His Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Ile 
            260                 265                 270         


Gln Leu His Ala Thr Asp Ala Asp Ile Gly Ser Asn Ala Glu Ile Arg 
        275                 280                 285             


Tyr Ile Phe Gly Ala Gln Val Ala Pro Ala Thr Lys Arg Leu Phe Ala 
    290                 295                 300                 


Leu Asn Asn Thr Thr Gly Leu Ile Thr Val Gln Arg Ser Leu Asp Arg 
305                 310                 315                 320 


Glu Glu Thr Ala Ile His Lys Val Thr Val Leu Ala Ser Asp Gly Ser 
                325                 330                 335     


Ser Thr Pro Ala Arg Ala Thr Val Thr Ile Asn Val Thr Asp Val Asn 
            340                 345                 350         


Asp Asn Pro Pro Asn Ile Asp Leu Arg Tyr Ile Ile Ser Pro Ile Asn 
        355                 360                 365             


Gly Thr Val Tyr Leu Ser Glu Lys Asp Pro Val Asn Thr Lys Ile Ala 
    370                 375                 380                 


Leu Ile Thr Val Ser Asp Lys Asp Thr Asp Val Asn Gly Lys Val Ile 
385                 390                 395                 400 


Cys Phe Ile Glu Arg Glu Val Pro Phe His Leu Lys Ala Val Tyr Asp 
                405                 410                 415     


Asn Gln Tyr Leu Leu Glu Thr Ser Ser Leu Leu Asp Tyr Glu Gly Thr 
            420                 425                 430         


Lys Glu Phe Ser Phe Lys Ile Val Ala Ser Asp Ser Gly Lys Pro Ser 
        435                 440                 445             


Leu Asn Gln Thr Ala Leu Val Arg Val Lys Leu Glu Asp Glu Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ile Phe Asn Gln Pro Val Ile Glu Leu Ser Val Ser Glu 
465                 470                 475                 480 


Asn Asn Arg Arg Gly Leu Tyr Leu Thr Thr Ile Ser Ala Thr Asp Glu 
                485                 490                 495     


Asp Ser Gly Lys Asn Ala Asp Ile Val Tyr Gln Leu Gly Pro Asn Ala 
            500                 505                 510         


Ser Phe Phe Asp Leu Asp Arg Lys Thr Gly Val Leu Thr Ala Ser Arg 
        515                 520                 525             


Val Phe Asp Arg Glu Glu Gln Glu Arg Phe Ile Phe Thr Val Thr Ala 
    530                 535                 540                 


Arg Asp Asn Gly Thr Pro Pro Leu Gln Ser Gln Ala Ala Val Ile Val 
545                 550                 555                 560 


Thr Val Leu Asp Glu Asn Asp Asn Ser Pro Lys Phe Thr His Asn His 
                565                 570                 575     


Phe Gln Phe Phe Val Ser Glu Asn Leu Pro Lys Tyr Ser Thr Val Gly 
            580                 585                 590         


Val Ile Thr Val Thr Asp Ala Asp Ala Gly Glu Asn Lys Ala Val Thr 
        595                 600                 605             


Leu Ser Ile Leu Asn Asp Asn Asp Asn Phe Val Leu Asp Pro Tyr Ser 
    610                 615                 620                 


Gly Val Ile Lys Ser Asn Val Ser Phe Asp Arg Glu Gln Gln Ser Ser 
625                 630                 635                 640 


Tyr Thr Phe Asp Val Lys Ala Thr Asp Gly Gly Gln Pro Pro Arg Ser 
                645                 650                 655     


Ser Thr Ala Lys Val Thr Ile Asn Val Met Asp Val Asn Asp Asn Ser 
            660                 665                 670         


Pro Val Val Ile Ser Pro Pro Ser Asn Thr Ser Phe Lys Leu Val Pro 
        675                 680                 685             


Leu Ser Ala Ile Pro Gly Ser Val Val Ala Glu Val Phe Ala Val Asp 
    690                 695                 700                 


Val Asp Thr Gly Met Asn Ala Glu Leu Lys Tyr Thr Ile Val Ser Gly 
705                 710                 715                 720 


Asn Asn Lys Gly Leu Phe Arg Ile Asp Pro Val Thr Gly Asn Ile Thr 
                725                 730                 735     


Leu Glu Glu Lys Pro Ala Pro Thr Asp Val Gly Leu His Arg Leu Val 
            740                 745                 750         


Val Asn Ile Ser Asp Leu Gly Tyr Pro Lys Ser Leu His Thr Leu Val 
        755                 760                 765             


Leu Val Phe Leu Tyr Val Asn Asp Thr Ala Gly Asn Ala Ser Tyr Ile 
    770                 775                 780                 


Tyr Asp Leu Ile Arg Arg Thr Met Glu Thr Pro Leu Asp Arg Asn Ile 
785                 790                 795                 800 


Gly Asp Ser Ser Gln Pro Tyr Gln Asn Glu Asp Tyr Leu Thr Ile Met 
                805                 810                 815     


Ile Ala Ile Ile Ala Gly Ala Met Val Val Ile Val Val Ile Phe Val 
            820                 825                 830         


Thr Val Leu Val Arg Cys Arg His Ala Ser Arg Phe Lys Ala Ala Gln 
        835                 840                 845             


Arg Ser Lys Gln Gly Ala Glu Trp Met Ser Pro Asn Gln Glu Asn Lys 
    850                 855                 860                 


Gln Asn Lys Lys Lys Lys Arg Lys Lys Arg Lys Ser Pro Lys Ser Ser 
865                 870                 875                 880 


Leu Leu Asn Phe Val Thr Ile Glu Glu Ser Lys Pro Asp Asp Ala Val 
                885                 890                 895     


His Glu Pro Ile Asn Gly Thr Ile Ser Leu Pro Ala Glu Leu Glu Glu 
            900                 905                 910         


Gln Ser Ile Gly Arg Phe Asp Trp Gly Pro Ala Pro Pro Thr Thr Phe 
        915                 920                 925             


Lys Pro Asn Ser Pro Asp Leu Ala Lys His Tyr Lys Ser Ala Ser Pro 
    930                 935                 940                 


Gln Pro Ala Phe His Leu Lys Pro Asp Thr Pro Val Ser Val Lys Lys 
945                 950                 955                 960 


His His Val Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Gly Gly 
                965                 970                 975     


Cys Asp Thr Leu Ser Lys Arg Ser Ser Thr Ser Ser Asp His Phe Ser 
            980                 985                 990         


Ala Ser Glu Cys Ser Ser Gln Gly  Gly Phe Lys Thr Lys  Gly Pro Leu 
        995                 1000                 1005             


His Thr  Arg Gln Cys Asn Ser  His Ser Lys Ser Asp  Asn Ile Pro 
    1010                 1015                 1020             


Val Thr  Pro Gln Lys Cys Pro  Ser Ser Thr Gly Phe  His Ile Gln 
    1025                 1030                 1035             


Glu Asn  Glu Glu Ser His Tyr  Glu Ser Gln Arg Arg  Val Thr Phe 
    1040                 1045                 1050             


His Leu  Pro Asp Gly Ser Gln  Glu Ser Cys Ser Asp  Ser Gly Leu 
    1055                 1060                 1065             


Gly Asp  His Glu Pro Val Gly  Ser Gly Thr Leu Ile  Ser His Pro 
    1070                 1075                 1080             


Leu Pro  Leu Val Gln Pro Gln  Asp Glu Phe Tyr Asp  Gln Ala Ser 
    1085                 1090                 1095             


Pro Asp  Lys Arg Thr Glu Ala  Asp Gly Asn Ser Asp  Pro Asn Ser 
    1100                 1105                 1110             


Asp Gly  Pro Leu Gly Pro Arg  Gly Leu Ala Glu Ala  Thr Glu Met 
    1115                 1120                 1125             


Cys Thr  Gln Glu Cys Leu Val  Leu Gly His Ser Asp  Asn Cys Trp 
    1130                 1135                 1140             


Met Pro  Pro Gly Leu Gly Pro  Tyr Gln His Pro Lys  Ser Pro Leu 
    1145                 1150                 1155             


Ser Thr  Phe Ala Pro Gln Lys  Glu Trp Val Lys Lys  Asp Lys Leu 
    1160                 1165                 1170             


Val Asn  Gly His Thr Leu Thr  Arg Ala Trp Lys Glu  Asp Ser Asn 
    1175                 1180                 1185             


Arg Asn  Gln Phe Asn Asp Arg  Lys Gln Tyr Gly Ser  Asn Glu Gly 
    1190                 1195                 1200             


His Phe  Asn Asn Gly Ser His  Met Thr Asp Ile Pro  Leu Ala Asn 
    1205                 1210                 1215             


Leu Lys  Ser Tyr Lys Gln Ala  Gly Gly Ala Thr Glu  Ser Pro Lys 
    1220                 1225                 1230             


Glu His  Gln Leu 
    1235         


<210>  398
<211>  800
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Ala Val Arg Glu Leu Cys Phe Pro Arg Gln Arg Gln Val Leu Phe 
1               5                   10                  15      


Leu Phe Leu Phe Trp Gly Val Ser Leu Ala Gly Ser Gly Phe Gly Arg 
            20                  25                  30          


Tyr Ser Val Thr Glu Glu Thr Glu Lys Gly Ser Phe Val Val Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Ala Glu Gly Glu Leu Ala Ala Arg Gly Thr 
    50                  55                  60                  


Arg Val Val Ser Asp Asp Asn Lys Gln Tyr Leu Leu Leu Asp Ser His 
65                  70                  75                  80  


Thr Gly Asn Leu Leu Thr Asn Glu Lys Leu Asp Arg Glu Lys Leu Cys 
                85                  90                  95      


Gly Pro Lys Glu Pro Cys Met Leu Tyr Phe Gln Ile Leu Met Asp Asp 
            100                 105                 110         


Pro Phe Gln Ile Tyr Arg Ala Glu Leu Arg Val Arg Asp Ile Asn Asp 
        115                 120                 125             


His Ala Pro Val Phe Gln Asp Lys Glu Thr Val Leu Lys Ile Ser Glu 
    130                 135                 140                 


Asn Thr Ala Glu Gly Thr Ala Phe Arg Leu Glu Arg Ala Gln Asp Pro 
145                 150                 155                 160 


Asp Gly Gly Leu Asn Gly Ile Gln Asn Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


Phe Phe His Ile Asn Ile Ser Gly Gly Asp Glu Gly Met Ile Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Arg Glu Glu Gln Gly Glu Leu 
        195                 200                 205             


Ser Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Ser Arg Ser Gly 
    210                 215                 220                 


Thr Ser Thr Val Arg Ile Val Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Gln Phe Ala Gln Ala Leu Tyr Glu Thr Gln Ala Pro Glu Asn Ser Pro 
                245                 250                 255     


Ile Gly Phe Leu Ile Val Lys Val Trp Ala Glu Asp Val Asp Ser Gly 
            260                 265                 270         


Val Asn Ala Glu Val Ser Tyr Ser Phe Phe Asp Ala Ser Glu Asn Ile 
        275                 280                 285             


Arg Thr Thr Phe Gln Ile Asn Pro Phe Ser Gly Glu Ile Phe Leu Arg 
    290                 295                 300                 


Glu Leu Leu Asp Tyr Glu Leu Val Asn Ser Tyr Lys Ile Asn Ile Gln 
305                 310                 315                 320 


Ala Met Asp Gly Gly Gly Leu Ser Ala Arg Cys Arg Val Leu Val Glu 
                325                 330                 335     


Val Leu Asp Thr Asn Asp Asn Pro Pro Glu Leu Ile Val Ser Ser Phe 
            340                 345                 350         


Ser Asn Ser Val Ala Glu Asn Ser Pro Glu Thr Pro Leu Ala Val Phe 
        355                 360                 365             


Lys Ile Asn Asp Arg Asp Ser Gly Glu Asn Gly Lys Met Val Cys Tyr 
    370                 375                 380                 


Ile Gln Glu Asn Leu Pro Phe Leu Leu Lys Pro Ser Val Glu Asn Phe 
385                 390                 395                 400 


Tyr Ile Leu Ile Thr Glu Gly Ala Leu Asp Arg Glu Ile Arg Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Arg Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Leu Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Glu Ala Asp Leu Leu 
        675                 680                 685             


Thr Val Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu 
    690                 695                 700                 


Leu Ser Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg 
705                 710                 715                 720 


Ala Ala Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly 
                725                 730                 735     


His Leu Val Asp Val Arg Gly Ala Glu Thr Leu Ser Gln Ser Tyr Gln 
            740                 745                 750         


Tyr Glu Val Cys Leu Thr Gly Gly Pro Gly Thr Ser Glu Phe Lys Phe 
        755                 760                 765             


Leu Lys Pro Val Ile Ser Asp Ile Gln Ala Gln Gly Pro Gly Arg Lys 
    770                 775                 780                 


Gly Glu Glu Asn Ser Thr Phe Arg Asn Ser Phe Gly Phe Asn Ile Gln 
785                 790                 795                 800 


<210>  399
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  399

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Ser Ser Gln Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly 
    1040                 1045                 1050             


Ser Ser  Ser Ser Thr Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu 
    1055                 1060                 1065             


Asp Ile  Asp Met Met Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu 
    1070                 1075                 1080             


Val Glu  Asp Ser Phe Leu 
    1085                 


<210>  400
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Ser Ser Gln Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly 
    1040                 1045                 1050             


Ser Ser  Ser Ser Thr Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu 
    1055                 1060                 1065             


Asp Ile  Asp Met Met Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu 
    1070                 1075                 1080             


Val Glu  Asp Ser Phe Leu 
    1085                 


<210>  401
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  401

Met Pro Gly Ala Glu Asp Asp Val Val Thr Pro Gly Thr Ser Glu Asp 
1               5                   10                  15      


Arg Tyr Lys Ser Gly Leu Thr Thr Leu Val Ala Thr Ser Val Asn Ser 
            20                  25                  30          


Val Thr Gly Ile Arg Ile Glu Asp Leu Pro Thr Ser Glu Ser Thr Val 
        35                  40                  45              


His Ala Gln Glu Gln Ser Pro Ser Ala Thr Ala Ser Asn Val Ala Thr 
    50                  55                  60                  


Ser His Ser Thr Glu Lys Val Asp Gly Asp Thr Gln Thr Thr Val Glu 
65                  70                  75                  80  


Lys Asp Gly Leu Ser Thr Val Thr Leu Val Gly Ile Ile Val Gly Val 
                85                  90                  95      


Leu Leu Ala Ile Gly Phe Ile Gly Ala Ile Ile Val Val Val Met Arg 
            100                 105                 110         


Lys Met Ser Gly Arg Tyr Ser Pro 
        115                 120 


<210>  402
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  402

Met Pro Gly Ala Glu Asp Asp Val Val Thr Pro Gly Thr Ser Glu Asp 
1               5                   10                  15      


Arg Tyr Lys Ser Gly Leu Thr Thr Leu Val Ala Thr Ser Val Asn Ser 
            20                  25                  30          


Val Thr Gly Ile Arg Ile Glu Asp Leu Pro Thr Ser Glu Ser Thr Val 
        35                  40                  45              


His Ala Gln Glu Gln Ser Pro Ser Ala Thr Ala Ser Asn Val Ala Thr 
    50                  55                  60                  


Ser His Ser Thr Glu Lys Val Asp Gly Asp Thr Gln Thr Thr Val Glu 
65                  70                  75                  80  


Lys Asp Gly Leu Ser Thr Val Thr Leu Val Gly Ile Ile Val Gly Val 
                85                  90                  95      


Leu Leu Ala Ile Gly Phe Ile Gly Ala Ile Ile Val Val Val Met Arg 
            100                 105                 110         


Lys Met Ser Gly Arg Pro 
        115             


<210>  403
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  403

Met Leu Thr Pro Leu Gly Lys Phe Ser Thr Ala Lys Phe Ala Val Arg 
1               5                   10                  15      


Leu Pro Arg Val Trp Glu Ala Arg Ala Pro Ser Leu Ser Gly Ala Pro 
            20                  25                  30          


Ala Pro Thr Pro Pro Ala Pro Pro Pro Ser Arg Ser Ser Arg Leu Gly 
        35                  40                  45              


Leu Trp Pro Arg Cys Phe Leu Ile Phe Pro Gln Leu Arg Ile Leu Leu 
    50                  55                  60                  


Leu Gly Pro Gln Glu Ser Asn Asn Ser Thr Gly Thr Met Trp Lys Val 
65                  70                  75                  80  


Ser Ala Leu Leu Phe Val Leu Gly Ser Ala Ser Leu Trp Val Leu Ala 
                85                  90                  95      


Glu Gly Ala Ser Thr Gly Gln Pro Glu Asp Asp Thr Glu Thr Thr Gly 
            100                 105                 110         


Leu Glu Gly Gly Val Ala Met Pro Gly Ala Glu Asp Asp Val Val Thr 
        115                 120                 125             


Pro Gly Thr Ser Glu Asp Arg Tyr Lys Ser Gly Leu Thr Thr Leu Val 
    130                 135                 140                 


Ala Thr Ser Val Asn Ser Val Thr Gly Ile Arg Ile Glu Asp Leu Pro 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Val His Ala Gln Glu Gln Ser Pro Ser Ala Thr 
                165                 170                 175     


Ala Ser Asn Val Ala Thr Ser His Ser Thr Glu Lys Val Asp Gly Asp 
            180                 185                 190         


Thr Gln Thr Thr Val Glu Lys Asp Gly Leu Ser Thr Val Thr Leu Val 
        195                 200                 205             


Gly Ile Ile Val Gly Val Leu Leu Ala Ile Gly Phe Ile Gly Ala Ile 
    210                 215                 220                 


Ile Val Val Val Met Arg Lys Met Ser Gly Arg Tyr Ser Pro 
225                 230                 235             


<210>  404
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  404

Met Leu Thr Pro Leu Gly Lys Phe Ser Thr Ala Lys Phe Ala Val Arg 
1               5                   10                  15      


Leu Pro Arg Val Trp Glu Ala Arg Ala Pro Ser Leu Ser Gly Ala Pro 
            20                  25                  30          


Ala Pro Thr Pro Pro Ala Pro Pro Pro Ser Arg Ser Ser Arg Leu Gly 
        35                  40                  45              


Leu Trp Pro Arg Cys Phe Leu Ile Phe Pro Gln Leu Arg Ile Leu Leu 
    50                  55                  60                  


Leu Gly Pro Gln Glu Ser Asn Asn Ser Thr Gly Thr Met Trp Lys Val 
65                  70                  75                  80  


Ser Ala Leu Leu Phe Val Leu Gly Ser Ala Ser Leu Trp Val Leu Ala 
                85                  90                  95      


Glu Gly Ala Ser Thr Gly Gln Pro Glu Asp Asp Thr Glu Thr Thr Gly 
            100                 105                 110         


Leu Glu Gly Gly Val Ala Met Pro Gly Ala Glu Asp Asp Val Val Thr 
        115                 120                 125             


Pro Gly Thr Ser Glu Asp Arg Tyr Lys Ser Gly Leu Thr Thr Leu Val 
    130                 135                 140                 


Ala Thr Ser Val Asn Ser Val Thr Gly Ile Arg Ile Glu Asp Leu Pro 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Val His Ala Gln Glu Gln Ser Pro Ser Ala Thr 
                165                 170                 175     


Ala Ser Asn Val Ala Thr Ser His Ser Thr Glu Lys Val Asp Gly Asp 
            180                 185                 190         


Thr Gln Thr Thr Val Glu Lys Asp Gly Leu Ser Thr Val Thr Leu Val 
        195                 200                 205             


Gly Ile Ile Val Gly Val Leu Leu Ala Ile Gly Phe Ile Gly Ala Ile 
    210                 215                 220                 


Ile Val Val Val Met Arg Lys Met Ser Gly Arg Pro 
225                 230                 235     


<210>  405
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  405

Met Thr Met Glu Thr Leu Pro Lys Val Leu Glu Val Asp Glu Lys Ser 
1               5                   10                  15      


Pro Glu Ala Lys Asp Leu Leu Pro Ser Gln Thr Ala Ser Ser Leu Cys 
            20                  25                  30          


Ile Ser Ser Arg Ser Glu Ser Val Trp Thr Thr Thr Pro Arg Ser Asn 
        35                  40                  45              


Trp Glu Ile Tyr Arg Lys Pro Ile Val Ile Met Ser Val Gly Gly Ala 
    50                  55                  60                  


Ile Leu Leu Phe Gly Val Val Ile Thr Cys Leu Ala Tyr Thr Leu Lys 
65                  70                  75                  80  


Leu Ser Asp Lys Ser Leu Ser Ile Leu Lys Met Val Gly Pro Gly Phe 
                85                  90                  95      


Leu Ser Leu Gly Leu Met Met Leu Val Cys Gly Leu Val Trp Val Pro 
            100                 105                 110         


Ile Ile Lys Lys Lys Gln Lys His Arg Gln Lys Ser Asn Phe Leu Arg 
        115                 120                 125             


Ser Leu Lys Ser Phe Phe Leu Thr Arg 
    130                 135         


<210>  406
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  406

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Gly Ser Gln Val Trp Gly Gly 
            20                  25                  30          


Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp Ala Cys Ile Phe Pro Asp 
        35                  40                  45              


Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser Gln Lys Arg Ser Phe Val 
    50                  55                  60                  


Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly Gly Pro 
65                  70                  75                  80  


Val Ser Gly Leu Ser Ile Gly Thr Gly Arg Ala Met Leu Gly Thr His 
                85                  90                  95      


Thr Met Glu Val Thr Val Tyr His Arg Arg Gly Ser Arg Ser Tyr Val 
            100                 105                 110         


Pro Leu Ala His Ser Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro 
        115                 120                 125             


Phe Ser Val Ser Val Ser Gln Leu Arg Ala Leu Asp Gly Gly Asn Lys 
    130                 135                 140                 


His Phe Leu Arg Asn Gln Pro Leu Thr Phe Ala Leu Gln Leu His Asp 
145                 150                 155                 160 


Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu Ser Tyr Thr Trp Asp Phe 
                165                 170                 175     


Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg Ala Leu Val Val Thr His 
            180                 185                 190         


Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala Gln Val Val Leu Gln Ala 
        195                 200                 205             


Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser Pro Val Pro Gly Thr Thr 
    210                 215                 220                 


Asp Gly His Arg Pro Thr Ala Glu Ala Pro Asn Thr Thr Ala Gly Gln 
225                 230                 235                 240 


Val Pro Thr Thr Glu Val Val Gly Thr Thr Pro Gly Gln Ala Pro Thr 
                245                 250                 255     


Ala Glu Pro Ser Gly Thr Thr Ser Val Gln Val Pro Thr Thr Glu Val 
            260                 265                 270         


Ile Ser Thr Ala Pro Val Gln Met Pro Thr Ala Glu Ser Thr Gly Met 
        275                 280                 285             


Thr Pro Glu Lys Val Pro Val Ser Glu Val Met Gly Thr Thr Leu Ala 
    290                 295                 300                 


Glu Met Ser Thr Pro Glu Ala Thr Gly Met Thr Pro Ala Glu Val Ser 
305                 310                 315                 320 


Ile Val Val Leu Ser Gly Thr Thr Ala Ala Gln Val Thr Thr Thr Glu 
                325                 330                 335     


Trp Val Glu Thr Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly 
            340                 345                 350         


Pro Asp Ala Ser Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu 
        355                 360                 365             


Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln 
    370                 375                 380                 


Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr 
385                 390                 395                 400 


Leu Asp Ile Val Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val 
                405                 410                 415     


Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly 
            420                 425                 430         


Gly Leu Pro Lys Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln 
        435                 440                 445             


Pro Pro Ala Gln Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys 
    450                 455                 460                 


Gln Leu Val Leu His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys 
465                 470                 475                 480 


Leu Asn Val Ser Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr 
                485                 490                 495     


Gln Leu Ile Met Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu 
            500                 505                 510         


Ile Val Gly Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu 
        515                 520                 525             


Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu 
    530                 535                 540                 


Pro His Ser Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser 
545                 550                 555                 560 


Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
                565                 570                 575 


<210>  407
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  407

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Val Pro Gly Ile Leu 
            580                 585                 590         


Leu Thr Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu Ile Val Gly 
        595                 600                 605             


Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile Tyr Arg 
    610                 615                 620                 


Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu Pro His Ser 
625                 630                 635                 640 


Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser Cys Pro Ile 
                645                 650                 655     


Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
            660                 665             


<210>  408
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  408

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Ala Ala Gln Val Thr Thr Thr Glu Trp Val Glu Thr 
    370                 375                 380                 


Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser 
385                 390                 395                 400 


Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu 
                405                 410                 415     


Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln Val Pro Leu Asp 
            420                 425                 430         


Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr Leu Asp Ile Val 
        435                 440                 445             


Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val Pro Ser Gly Glu 
    450                 455                 460                 


Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly Gly Leu Pro Lys 
465                 470                 475                 480 


Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln 
                485                 490                 495     


Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys Gln Leu Val Leu 
            500                 505                 510         


His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser 
        515                 520                 525             


Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr Gln Leu Ile Met 
    530                 535                 540                 


Pro Val Pro Gly Ile Leu Leu Thr Gly Gln Glu Ala Gly Leu Gly Gln 
545                 550                 555                 560 


Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala Val Val Leu 
                565                 570                 575     


Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp Phe Ser Val 
            580                 585                 590         


Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu Pro Arg Ile 
        595                 600                 605             


Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln 
    610                 615                 620                 


Gln Val 
625     


<210>  409
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  409

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Ala Ala Gln Val Thr Thr Thr Glu Trp Val Glu Thr 
    370                 375                 380                 


Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser 
385                 390                 395                 400 


Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu 
                405                 410                 415     


Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln Val Pro Leu Asp 
            420                 425                 430         


Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr Leu Asp Ile Val 
        435                 440                 445             


Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val Pro Ser Gly Glu 
    450                 455                 460                 


Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly Gly Leu Pro Lys 
465                 470                 475                 480 


Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln 
                485                 490                 495     


Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys Gln Leu Val Leu 
            500                 505                 510         


His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser 
        515                 520                 525             


Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr Gln Leu Ile Met 
    530                 535                 540                 


Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu Ile Val Gly Ile 
545                 550                 555                 560 


Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile Tyr Arg Arg 
                565                 570                 575     


Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu Pro His Ser Ser 
            580                 585                 590         


Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly 
        595                 600                 605             


Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
    610                 615                 


<210>  410
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  410

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 
            580                 585                 590         


Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 
        595                 600                 605             


Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 
    610                 615                 620                 


Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 
625                 630                 635                 640 


Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 
                645                 650                 655     


Ser Gly Gln Gln Val 
            660     


<210>  411
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  411

Met Pro Ala Ile Pro Ala His Gly Ala Glu Leu Glu Phe Val Gln Ile 
1               5                   10                  15      


Ile Ile Ile Val Val Val Met Met Val Met Val Val Val Ile Thr Cys 
            20                  25                  30          


Leu Leu Ser His Tyr Lys Leu Ser Ala Arg Ser Phe Ile Ser Arg His 
        35                  40                  45              


Ser Gln Gly Arg Arg Arg Glu Asp Ala Leu Ser Ser Glu Gly Cys Leu 
    50                  55                  60                  


Trp Pro Ser Glu Ser Thr Val Ser Gly Asn Gly Ile Pro Glu Pro Gln 
65                  70                  75                  80  


Val Tyr Ala Pro Pro Arg Pro Thr Asp Arg Leu Ala Val Pro Pro Phe 
                85                  90                  95      


Ala Gln Arg Glu Arg Phe His Arg Phe Gln Pro Thr Tyr Pro Tyr Leu 
            100                 105                 110         


Gln His Glu Ile Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu 
        115                 120                 125             


Glu Pro Pro Pro Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro 
    130                 135                 140                 


Glu Gln Gln Leu Glu Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn 
145                 150                 155                 160 


Arg Thr Ile Phe Asp Ser Asp Leu Met Asp Ser Ala Arg Leu Gly Gly 
                165                 170                 175     


Pro Cys Pro Pro Ser Ser Asn Ser Gly Ile Ser Ala Thr Cys Tyr Gly 
            180                 185                 190         


Ser Gly Gly Arg Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val Ile 
        195                 200                 205             


Gly His Tyr Pro Gly Ser Ser Phe Gln His Gln Gln Ser Ser Gly Pro 
    210                 215                 220                 


Pro Ser Leu Leu Glu Gly Thr Arg Leu His His Thr His Ile Ala Pro 
225                 230                 235                 240 


Leu Glu Ser Ala Ala Ile Trp Ser Lys Glu Lys Asp Lys Gln Lys Gly 
                245                 250                 255     


His Pro Leu 
            


<210>  412
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  412

Met His Arg Leu Met Gly Val Asn Ser Thr Ala Ala Ala Ala Ala Gly 
1               5                   10                  15      


Gln Pro Asn Val Ser Cys Thr Cys Asn Cys Lys Arg Ser Leu Phe Gln 
            20                  25                  30          


Ser Met Glu Ile Thr Glu Leu Glu Phe Val Gln Ile Ile Ile Ile Val 
        35                  40                  45              


Val Val Met Met Val Met Val Val Val Ile Thr Cys Leu Leu Ser His 
    50                  55                  60                  


Tyr Lys Leu Ser Ala Arg Ser Phe Ile Ser Arg His Ser Gln Gly Arg 
65                  70                  75                  80  


Arg Arg Glu Asp Ala Leu Ser Ser Glu Gly Cys Leu Trp Pro Ser Glu 
                85                  90                  95      


Ser Thr Val Ser Gly Asn Gly Ile Pro Glu Pro Gln Val Tyr Ala Pro 
            100                 105                 110         


Pro Arg Pro Thr Asp Arg Leu Ala Val Pro Pro Phe Ala Gln Arg Glu 
        115                 120                 125             


Arg Phe His Arg Phe Gln Pro Thr Tyr Pro Tyr Leu Gln His Glu Ile 
    130                 135                 140                 


Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro Pro 
145                 150                 155                 160 


Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln Leu 
                165                 170                 175     


Glu Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile Phe 
            180                 185                 190         


Asp Ser Asp Leu Met Asp Ser Ala Arg Leu Gly Gly Pro Cys Pro Pro 
        195                 200                 205             


Ser Ser Asn Ser Gly Ile Ser Ala Thr Cys Tyr Gly Ser Gly Gly Arg 
    210                 215                 220                 


Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val Ile Gly His Tyr Pro 
225                 230                 235                 240 


Gly Ser Ser Phe Gln His Gln Gln Ser Ser Gly Pro Pro Ser Leu Leu 
                245                 250                 255     


Glu Gly Thr Arg Leu His His Thr His Ile Ala Pro Leu Glu Ser Ala 
            260                 265                 270         


Ala Ile Trp Ser Lys Glu Lys Asp Lys Gln Lys Gly His Pro Leu 
        275                 280                 285         


<210>  413
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  413

Met Ala Glu Leu Glu Phe Val Gln Ile Ile Ile Ile Val Val Val Met 
1               5                   10                  15      


Met Val Met Val Val Val Ile Thr Cys Leu Leu Ser His Tyr Lys Leu 
            20                  25                  30          


Ser Ala Arg Ser Phe Ile Ser Arg His Ser Gln Gly Arg Arg Arg Glu 
        35                  40                  45              


Asp Ala Leu Ser Ser Glu Gly Cys Leu Trp Pro Ser Glu Ser Thr Val 
    50                  55                  60                  


Ser Gly Asn Gly Ile Pro Glu Pro Gln Val Tyr Ala Pro Pro Arg Pro 
65                  70                  75                  80  


Thr Asp Arg Leu Ala Val Pro Pro Phe Ala Gln Arg Glu Arg Phe His 
                85                  90                  95      


Arg Phe Gln Pro Thr Tyr Pro Tyr Leu Gln His Glu Ile Asp Leu Pro 
            100                 105                 110         


Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro Pro Tyr Gln Gly 
        115                 120                 125             


Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln Leu Glu Leu Asn 
    130                 135                 140                 


Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile Phe Asp Ser Asp 
145                 150                 155                 160 


Leu Met Asp Ser Ala Arg Leu Gly Gly Pro Cys Pro Pro Ser Ser Asn 
                165                 170                 175     


Ser Gly Ile Ser Ala Thr Cys Tyr Gly Ser Gly Gly Arg Met Glu Gly 
            180                 185                 190         


Pro Pro Pro Thr Tyr Ser Glu Val Ile Gly His Tyr Pro Gly Ser Ser 
        195                 200                 205             


Phe Gln His Gln Gln Ser Ser Gly Pro Pro Ser Leu Leu Glu Gly Thr 
    210                 215                 220                 


Arg Leu His His Thr His Ile Ala Pro Leu Glu Ser Ala Ala Ile Trp 
225                 230                 235                 240 


Ser Lys Glu Lys Asp Lys Gln Lys Gly His Pro Leu 
                245                 250         


<210>  414
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  414

Met Met Val Met Val Val Val Ile Thr Cys Leu Leu Ser His Tyr Lys 
1               5                   10                  15      


Leu Ser Ala Arg Ser Phe Ile Ser Arg His Ser Gln Gly Arg Arg Arg 
            20                  25                  30          


Glu Asp Ala Leu Ser Ser Glu Gly Cys Leu Trp Pro Ser Glu Ser Thr 
        35                  40                  45              


Val Ser Gly Asn Gly Ile Pro Glu Pro Gln Val Tyr Ala Pro Pro Arg 
    50                  55                  60                  


Pro Thr Asp Arg Leu Ala Val Pro Pro Phe Ala Gln Arg Glu Arg Phe 
65                  70                  75                  80  


His Arg Phe Gln Pro Thr Tyr Pro Tyr Leu Gln His Glu Ile Asp Leu 
                85                  90                  95      


Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro Pro Tyr Gln 
            100                 105                 110         


Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln Leu Glu Leu 
        115                 120                 125             


Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile Phe Asp Ser 
    130                 135                 140                 


Asp Leu Met Asp Ser Ala Arg Leu Gly Gly Pro Cys Pro Pro Ser Ser 
145                 150                 155                 160 


Asn Ser Gly Ile Ser Ala Thr Cys Tyr Gly Ser Gly Gly Arg Met Glu 
                165                 170                 175     


Gly Pro Pro Pro Thr Tyr Ser Glu Val Ile Gly His Tyr Pro Gly Ser 
            180                 185                 190         


Ser Phe Gln His Gln Gln Ser Ser Gly Pro Pro Ser Leu Leu Glu Gly 
        195                 200                 205             


Thr Arg Leu His His Thr His Ile Ala Pro Leu Glu Ser Ala Ala Ile 
    210                 215                 220                 


Trp Ser Lys Glu Lys Asp Lys Gln Lys Gly His Pro Leu 
225                 230                 235         


<210>  415
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  415

Met Met Val Met Val Val Val Ile Thr Cys Leu Leu Ser His Tyr Lys 
1               5                   10                  15      


Leu Ser Ala Arg Ser Phe Ile Ser Arg His Ser Gln Gly Arg Arg Arg 
            20                  25                  30          


Glu Asp Ala Leu Ser Ser Glu Gly Cys Leu Trp Pro Ser Glu Ser Thr 
        35                  40                  45              


Val Ser Gly Asn Gly Ile Pro Glu Pro Gln Val Tyr Ala Pro Pro Arg 
    50                  55                  60                  


Pro Thr Asp Arg Leu Ala Val Pro Pro Phe Ala Gln Arg Glu Arg Phe 
65                  70                  75                  80  


His Arg Phe Gln Pro Thr Tyr Pro Tyr Leu Gln His Glu Ile Asp Leu 
                85                  90                  95      


Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro Pro Tyr Gln 
            100                 105                 110         


Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln Leu Glu Leu 
        115                 120                 125             


Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile Phe Asp Ser 
    130                 135                 140                 


Asp Leu Met Asp Ser Ala Arg Leu Gly Gly Pro Cys Pro Pro Ser Ser 
145                 150                 155                 160 


Asn Ser Gly Ile Ser Ala Thr Cys Tyr Gly Ser Gly Gly Arg Met Glu 
                165                 170                 175     


Gly Pro Pro Pro Thr Tyr Ser Glu Val Ile Gly His Tyr Pro Gly Ser 
            180                 185                 190         


Ser Phe Gln His Gln Gln Ser Ser Gly Pro Pro Ser Leu Leu Glu Gly 
        195                 200                 205             


Thr Arg Leu His His Thr His Ile Ala Pro Leu Glu Ser Ala Ala Ile 
    210                 215                 220                 


Trp Ser Lys Glu Lys Asp Lys Gln Lys Gly His Pro Leu 
225                 230                 235         


<210>  416
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  416

Met Arg Glu Leu Ala Ile Glu Ile Gly Val Arg Ala Leu Leu Phe Gly 
1               5                   10                  15      


Val Phe Val Phe Thr Glu Phe Leu Asp Pro Phe Gln Arg Val Ile Gln 
            20                  25                  30          


Pro Glu Glu Ile Trp Leu Tyr Lys Asn Pro Leu Val Gln Ser Asp Asn 
        35                  40                  45              


Ile Pro Thr Arg Leu Met Phe Ala Ile Ser Phe Leu Thr Pro Leu Ala 
    50                  55                  60                  


Val Ile Cys Val Val Lys Ile Ile Arg Arg Thr Asp Lys Thr Glu Ile 
65                  70                  75                  80  


Lys Glu Ala Phe Leu Ala Val Ser Leu Ala Leu Ala Leu Asn Gly Val 
                85                  90                  95      


Cys Thr Asn Thr Ile Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe 
            100                 105                 110         


Phe Tyr Arg Cys Phe Pro Asp Gly Val Met Asn Ser Glu Met His Cys 
        115                 120                 125             


Thr Gly Asp Pro Asp Leu Val Ser Glu Gly Arg Lys Ser Phe Pro Ser 
    130                 135                 140                 


Ile His Ser Ser Phe Ala Phe Ser Gly Leu Gly Phe Thr Thr Phe Tyr 
145                 150                 155                 160 


Leu Ala Gly Lys Leu His Cys Phe Thr Glu Ser Gly Arg Gly Lys Ser 
                165                 170                 175     


Trp Arg Leu Cys Ala Ala Ile Leu Pro Leu Tyr Cys Ala Met Met Ile 
            180                 185                 190         


Ala Leu Ser Arg Met Cys Asp Tyr Lys His His Trp Gln Asp Ser Phe 
        195                 200                 205             


Val Gly Gly Val Ile Gly Leu Ile Phe Ala Tyr Ile Cys Tyr Arg Gln 
    210                 215                 220                 


His Tyr Pro Pro Leu Ala Asn Thr Ala Cys His Lys Pro Tyr Val Ser 
225                 230                 235                 240 


Leu Arg Val Pro Ala Ser Leu Lys Lys Glu Glu Arg Pro Thr Ala Asp 
                245                 250                 255     


Ser Ala Pro Ser Leu Pro Leu Glu Gly Ile Thr Glu Gly Pro Val 
            260                 265                 270     


<210>  417
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  417

Met Arg Glu Leu Ala Ile Glu Ile Gly Val Arg Ala Leu Leu Phe Gly 
1               5                   10                  15      


Val Phe Val Phe Thr Glu Phe Leu Asp Pro Phe Gln Arg Val Ile Gln 
            20                  25                  30          


Pro Glu Glu Ile Trp Leu Tyr Lys Asn Pro Leu Val Gln Ser Asp Asn 
        35                  40                  45              


Ile Pro Thr Arg Leu Met Phe Ala Ile Ser Phe Leu Thr Pro Leu Ala 
    50                  55                  60                  


Val Ile Cys Val Val Lys Ile Ile Arg Arg Thr Asp Lys Thr Glu Ile 
65                  70                  75                  80  


Lys Glu Ala Phe Leu Ala Val Ser Leu Ala Leu Ala Leu Asn Gly Val 
                85                  90                  95      


Cys Thr Asn Thr Ile Lys Leu Ile Val Gly Ser Cys Leu Phe Gly Pro 
            100                 105                 110         


Trp Leu His Asp Val Leu Leu Gly Gly Gln Ala Ala Leu Leu His Arg 
        115                 120                 125             


Glu Trp Ala Gly Lys Glu Leu Ala Ala Leu Cys Cys His Pro Ala Leu 
    130                 135                 140                 


Val Leu Arg His Asp Asp Cys Pro Val Pro His Val Arg Leu Gln Ala 
145                 150                 155                 160 


Ser Leu Ala Arg Phe Leu Cys Gly Trp Ser His Arg Pro His Phe Cys 
                165                 170                 175     


Ile His Leu Leu Gln Thr Ala Leu Ser Ser Ser Gly Gln His Ser Leu 
            180                 185                 190         


Pro 
    


<210>  418
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  418

Met Arg Glu Leu Ala Ile Glu Ile Gly Val Arg Ala Leu Leu Phe Gly 
1               5                   10                  15      


Val Phe Val Phe Thr Glu Phe Leu Asp Pro Phe Gln Arg Val Ile Gln 
            20                  25                  30          


Pro Glu Glu Ile Trp Leu Tyr Lys Asn Pro Leu Val Gln Ser Asp Asn 
        35                  40                  45              


Ile Pro Thr Arg Leu Met Phe Ala Ile Ser Phe Leu Thr Pro Leu Ala 
    50                  55                  60                  


Val Ile Cys Val Val Lys Ile Ile Arg Arg Thr Asp Lys Thr Glu Ile 
65                  70                  75                  80  


Lys Glu Ala Phe Leu Val Ala Phe Ser Gly Leu Gly Phe Thr Thr Phe 
                85                  90                  95      


Tyr Leu Ala Gly Lys Leu His Cys Phe Thr Glu Ser Gly Arg Gly Lys 
            100                 105                 110         


Ser Trp Arg Leu Cys Ala Ala Ile Leu Pro Leu Tyr Cys Ala Met Met 
        115                 120                 125             


Ile Ala Leu Ser Arg Met Cys Asp Tyr Lys His His Trp Gln Asp Ser 
    130                 135                 140                 


Phe Val Gly Gly Val Ile Gly Leu Ile Phe Ala Tyr Ile Cys Tyr Arg 
145                 150                 155                 160 


Gln His Tyr Pro Pro Leu Ala Asn Thr Ala Cys His Lys Pro Tyr Val 
                165                 170                 175     


Ser Leu Arg Val Pro Ala Ser Leu Lys Lys Glu Glu Arg Pro Thr Ala 
            180                 185                 190         


Asp Ser Ala Pro Ser Leu Pro Leu Glu Gly Ile Thr Glu Gly Pro Val 
        195                 200                 205             


<210>  419
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  419

Met Arg Glu Leu Ala Ile Glu Ile Gly Val Arg Ala Leu Leu Phe Gly 
1               5                   10                  15      


Val Phe Val Phe Thr Glu Phe Leu Asp Pro Phe Gln Arg Val Ile Gln 
            20                  25                  30          


Pro Glu Glu Ile Trp Leu Tyr Lys Asn Pro Leu Val Gln Ser Asp Asn 
        35                  40                  45              


Ile Pro Thr Arg Leu Met Phe Leu Pro Phe Arg Ala Leu Ala Ser Arg 
    50                  55                  60                  


Arg Ser Thr Trp Arg Ala Ser Cys Thr Ala Ser Pro Arg Val Gly Gly 
65                  70                  75                  80  


Glu Arg Ala Gly Gly Ser Val Leu Pro Ser Cys Pro Cys Thr Ala Pro 
                85                  90                  95      


<210>  420
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  420

Met Arg Glu Leu Ala Ile Glu Ile Gly Val Arg Ala Leu Leu Phe Gly 
1               5                   10                  15      


Val Phe Val Phe Thr Glu Phe Leu Asp Pro Phe Gln Arg Val Ile Gln 
            20                  25                  30          


Pro Glu Glu Ile Trp Leu Tyr Lys Asn Pro Leu Val Gln Ser Asp Asn 
        35                  40                  45              


Ile Pro Thr Arg Leu Met Phe Ile Pro Leu Trp Val Glu Ser Ser Ala 
    50                  55                  60                  


Ser Phe Leu His Thr Phe Ala Thr Asp Ser Thr Ile Leu Leu Trp Pro 
65                  70                  75                  80  


Thr Gln Leu Ala Ile Asn Pro Thr Leu Val Cys Glu Ser Gln Pro His 
                85                  90                  95      


<210>  421
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  421

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95      


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110         


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140                 


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160 


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175     


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190         


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205             


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220                 


Asn Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240 


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255     


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270         


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285             


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser 
    290                 295                 300                 


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320 


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335     


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350         


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365             


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380                 


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Ala Phe 
385                 390                 395                 400 


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415     


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430         


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445             


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Val Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495     


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510         


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525             


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540                 


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560 


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu 
                565                 570                 575     


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590         


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605             


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620                 


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640 


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655     


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670         


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685             


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700                 


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720 


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735     


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750         


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765             


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780                 


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800 


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815     


Asp Val Tyr Asp Asp Val Glu Thr Ile Pro Met Lys Asn Met Glu Asn 
            820                 825                 830         


Gly Asn Asn Gly Tyr His Lys Asp His Val Tyr Gly Ile His Asn Pro 
        835                 840                 845             


Val Met Thr Ser Pro Ser Gln His 
    850                 855     


<210>  422
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  422

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95      


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110         


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140                 


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160 


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175     


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190         


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205             


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220                 


Asn Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240 


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255     


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270         


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285             


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser 
    290                 295                 300                 


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320 


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335     


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350         


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365             


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380                 


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Ala Phe 
385                 390                 395                 400 


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415     


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430         


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445             


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Val Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495     


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510         


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525             


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540                 


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560 


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu 
                565                 570                 575     


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590         


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605             


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620                 


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640 


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655     


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670         


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685             


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700                 


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720 


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735     


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750         


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765             


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780                 


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800 


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815     


Asp Val Tyr Asp Asp Val Glu Thr Ile Pro Met Lys Asn Met Glu Asn 
            820                 825                 830         


Gly Asn Asn Gly Tyr His Lys Asp His Val Tyr Gly Ile His Asn Pro 
        835                 840                 845             


Val Met Thr Ser Pro Ser Gln His 
    850                 855     


<210>  423
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  423

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Pro Ser Gln His 
        835                 840         


<210>  424
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  424

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Pro Ser 
            820                 825                 830         


Gln His 
        


<210>  425
<211>  833
<212>  PRT
<213>  Homo sapiens

<400>  425

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95      


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110         


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140                 


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160 


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175     


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190         


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205             


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220                 


Asn Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240 


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255     


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270         


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285             


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser 
    290                 295                 300                 


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320 


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335     


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350         


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365             


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380                 


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Ala Phe 
385                 390                 395                 400 


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415     


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430         


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445             


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Val Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495     


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510         


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525             


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540                 


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560 


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu 
                565                 570                 575     


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590         


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605             


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620                 


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640 


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655     


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670         


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685             


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700                 


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720 


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735     


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750         


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765             


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780                 


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800 


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815     


Asp Val Tyr Asp Asp Val Glu Thr Ile Pro Met Lys Asn Pro Ser Gln 
            820                 825                 830         


His 
    


<210>  426
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  426

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95      


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110         


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125             


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140                 


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160 


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175     


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190         


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205             


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220                 


Asn Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240 


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255     


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270         


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285             


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser 
    290                 295                 300                 


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320 


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335     


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350         


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365             


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380                 


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Ala Phe 
385                 390                 395                 400 


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415     


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430         


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445             


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460                 


Cys Val Ser Asn Thr Gly Gly Val Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480 


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495     


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510         


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525             


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540                 


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560 


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu 
                565                 570                 575     


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590         


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605             


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620                 


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640 


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655     


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670         


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685             


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700                 


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720 


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735     


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750         


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765             


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780                 


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800 


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815     


Asp Val Tyr Asp Asp Pro Ser Gln His 
            820                 825 


<210>  427
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  427

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845             


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860                 


His 
865 


<210>  428
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  428

Met His Ser Leu Asn Lys Thr Trp Ala Asn Tyr Ser Asp Cys Leu Arg 
1               5                   10                  15      


Phe Leu Gln Pro Asp Ile Ser Ile Gly Lys Gln Glu Phe Phe Glu Arg 
            20                  25                  30          


Leu Tyr Val Met Tyr Thr Val Gly Tyr Ser Ile Ser Phe Gly Ser Leu 
        35                  40                  45              


Ala Val Ala Ile Leu Ile Ile Gly Tyr Phe Arg Arg Leu His Cys Thr 
    50                  55                  60                  


Arg Asn Tyr Ile His Met His Leu Phe Val Ser Phe Met Leu Arg Ala 
65                  70                  75                  80  


Thr Ser Ile Phe Val Lys Asp Arg Val Val His Ala His Ile Gly Val 
                85                  90                  95      


Lys Glu Leu Glu Ser Leu Ile Met Gln Asp Asp Pro Gln Asn Ser Ile 
            100                 105                 110         


Glu Ala Thr Ser Val Asp Lys Ser Gln Tyr Ile Gly Cys Lys Ile Ala 
        115                 120                 125             


Val Val Met Phe Ile Tyr Phe Leu Ala Thr Asn Tyr Tyr Trp Ile Leu 
    130                 135                 140                 


Val Glu Gly Leu Tyr Leu His Asn Leu Ile Phe Val Ala Phe Phe Ser 
145                 150                 155                 160 


Asp Thr Lys Tyr Leu Trp Gly Phe Ile Leu Ile Gly Trp Gly Phe Pro 
                165                 170                 175     


Ala Ala Phe Val Ala Ala Trp Ala Val Ala Arg Ala Thr Leu Ala Asp 
            180                 185                 190         


Ala Arg Cys Trp Glu Leu Ser Ala Gly Asp Ile Lys Trp Ile Tyr Gln 
        195                 200                 205             


Ala Pro Ile Leu Ala Ala Ile Gly Leu Asn Phe Ile Leu Phe Leu Asn 
    210                 215                 220                 


Thr Val Arg Val Leu Ala Thr Lys Ile Trp Glu Thr Asn Ala Val Gly 
225                 230                 235                 240 


His Asp Thr Arg Lys Gln Tyr Arg Lys Leu Ala Lys Ser Thr Leu Val 
                245                 250                 255     


Leu Val Leu Val Phe Gly Val His Tyr Ile Val Phe Val Cys Leu Pro 
            260                 265                 270         


His Ser Phe Thr Gly Leu Gly Trp Glu Ile Arg Met His Cys Glu Leu 
        275                 280                 285             


Phe Phe Asn Ser Phe Gln Gly Phe Phe Val Ser Ile Ile Tyr Cys Tyr 
    290                 295                 300                 


Cys Asn Gly Glu Val Gln Ala Glu Val Lys Lys Met Trp Ser Arg Trp 
305                 310                 315                 320 


Asn Leu Ser Val Asp Trp Lys Arg Thr Pro Pro Cys Gly Ser Arg Arg 
                325                 330                 335     


Cys Gly Ser Val Leu Thr Thr Val Thr His Ser Thr Ser Ser Gln Ser 
            340                 345                 350         


Gln Val Ala Ala Ser Thr Arg Met Val Leu Ile Ser Gly Lys Ala Ala 
        355                 360                 365             


Lys Ile Ala Ser Arg Gln Pro Asp Ser His Ile Thr Leu Pro Gly Tyr 
    370                 375                 380                 


Val Trp Ser Asn Ser Glu Gln Asp Cys Leu Pro His Ser Phe His Glu 
385                 390                 395                 400 


Glu Thr Lys Glu Asp Ser Gly Arg Gln Gly Asp Asp Ile Leu Met Glu 
                405                 410                 415     


Lys Pro Ser Arg Pro Met Glu Ser Asn Pro Asp Thr Glu Gly Cys Gln 
            420                 425                 430         


Gly Glu Thr Glu Asp Val Leu 
        435                 


<210>  429
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  429

Met Ala Gly Leu Gly Ala Ser Leu His Val Trp Gly Trp Leu Met Leu 
1               5                   10                  15      


Gly Ser Cys Leu Leu Ala Arg Ala Gln Leu Asp Ser Asp Gly Thr Ile 
            20                  25                  30          


Thr Ile Glu Glu Gln Ile Val Leu Val Leu Lys Ala Lys Val Gln Cys 
        35                  40                  45              


Glu Leu Asn Ile Thr Ala Gln Leu Gln Glu Gly Glu Gly Asn Cys Phe 
    50                  55                  60                  


Pro Glu Trp Asp Gly Leu Ile Cys Trp Pro Arg Gly Thr Val Gly Lys 
65                  70                  75                  80  


Ile Ser Ala Val Pro Cys Pro Pro Tyr Ile Tyr Asp Phe Asn His Lys 
                85                  90                  95      


Gly Val Ala Phe Arg His Cys Asn Pro Asn Gly Thr Trp Asp Phe Met 
            100                 105                 110         


His Ser Leu Asn Lys Thr Trp Ala Asn Tyr Ser Asp Cys Leu Arg Phe 
        115                 120                 125             


Leu Gln Pro Asp Ile Ser Ile Gly Lys Gln Glu Phe Phe Glu Arg Leu 
    130                 135                 140                 


Tyr Val Met Tyr Thr Val Gly Tyr Ser Ile Ser Phe Gly Ser Leu Ala 
145                 150                 155                 160 


Val Ala Ile Leu Ile Ile Gly Tyr Phe Arg Arg Leu His Cys Thr Arg 
                165                 170                 175     


Asn Tyr Ile His Met His Leu Phe Val Ser Phe Met Leu Arg Ala Thr 
            180                 185                 190         


Ser Ile Phe Val Lys Asp Arg Val Val His Ala His Ile Gly Val Lys 
        195                 200                 205             


Glu Leu Glu Ser Leu Ile Met Gln Asp Asp Pro Gln Asn Ser Ile Glu 
    210                 215                 220                 


Ala Thr Ser Val Asp Lys Ser Gln Tyr Ile Gly Cys Lys Ile Ala Val 
225                 230                 235                 240 


Val Met Phe Ile Tyr Phe Leu Ala Thr Asn Tyr Tyr Trp Ile Leu Val 
                245                 250                 255     


Glu Gly Leu Tyr Leu His Asn Leu Ile Phe Val Ala Phe Phe Ser Asp 
            260                 265                 270         


Thr Lys Tyr Leu Trp Gly Phe Ile Leu Ile Gly Trp Gly Phe Pro Ala 
        275                 280                 285             


Ala Phe Val Ala Ala Trp Ala Val Ala Arg Ala Thr Leu Ala Asp Ala 
    290                 295                 300                 


Arg Cys Trp Glu Leu Ser Ala Gly Asp Ile Lys Trp Ile Tyr Gln Ala 
305                 310                 315                 320 


Pro Ile Leu Ala Ala Ile Gly Leu Asn Phe Ile Leu Phe Leu Asn Thr 
                325                 330                 335     


Val Arg Val Leu Ala Thr Lys Ile Trp Glu Thr Asn Ala Val Gly His 
            340                 345                 350         


Asp Thr Arg Lys Gln Tyr Arg Lys Leu Ala Lys Ser Thr Leu Val Leu 
        355                 360                 365             


Val Leu Val Phe Gly Val His Tyr Ile Val Phe Val Cys Leu Pro His 
    370                 375                 380                 


Ser Phe Thr Gly Leu Gly Trp Glu Ile Arg Met His Cys Glu Leu Phe 
385                 390                 395                 400 


Phe Asn Ser Phe Gln Gly Phe Phe Val Ser Ile Ile Tyr Cys Tyr Cys 
                405                 410                 415     


Asn Gly Glu Val Gln Ala Glu Val Lys Lys Met Trp Ser Arg Trp Asn 
            420                 425                 430         


Leu Ser Val Asp Trp Lys Arg Thr Pro Pro Cys Gly Ser Arg Arg Cys 
        435                 440                 445             


Gly Ser Val Leu Thr Thr Val Thr His Ser Thr Ser Ser Gln Ser Gln 
    450                 455                 460                 


Val Ala Ala Ser Thr Arg Met Val Leu Ile Ser Gly Lys Ala Ala Lys 
465                 470                 475                 480 


Ile Ala Ser Arg Gln Pro Asp Ser His Ile Thr Leu Pro Gly Tyr Val 
                485                 490                 495     


Trp Ser Asn Ser Glu Gln Asp Cys Leu Pro His Ser Phe His Glu Glu 
            500                 505                 510         


Thr Lys Glu Asp Ser Gly Arg Gln Gly Asp Asp Ile Leu Met Glu Lys 
        515                 520                 525             


Pro Ser Arg Pro Met Glu Ser Asn Pro Asp Thr Glu Gly Cys Gln Gly 
    530                 535                 540                 


Glu Thr Glu Asp Val Leu 
545                 550 


<210>  430
<211>  1455
<212>  PRT
<213>  Homo sapiens

<400>  430

Met Arg Ile Leu Lys Arg Phe Leu Ala Cys Ile Gln Leu Leu Cys Val 
1               5                   10                  15      


Cys Arg Leu Asp Trp Ala Asn Gly Tyr Tyr Arg Gln Gln Arg Lys Leu 
            20                  25                  30          


Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn 
        35                  40                  45              


Trp Gly Lys Lys Tyr Pro Thr Cys Asn Ser Pro Lys Gln Ser Pro Ile 
    50                  55                  60                  


Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu 
65                  70                  75                  80  


Lys Phe Gln Gly Trp Asp Lys Thr Ser Leu Glu Asn Thr Phe Ile His 
                85                  90                  95      


Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Arg Val 
            100                 105                 110         


Ser Gly Gly Val Ser Glu Met Val Phe Lys Ala Ser Lys Ile Thr Phe 
        115                 120                 125             


His Trp Gly Lys Cys Asn Met Ser Ser Asp Gly Ser Glu His Ser Leu 
    130                 135                 140                 


Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala 
145                 150                 155                 160 


Asp Arg Phe Ser Ser Phe Glu Glu Ala Val Lys Gly Lys Gly Lys Leu 
                165                 170                 175     


Arg Ala Leu Ser Ile Leu Phe Glu Val Gly Thr Glu Glu Asn Leu Asp 
            180                 185                 190         


Phe Lys Ala Ile Ile Asp Gly Val Glu Ser Val Ser Arg Phe Gly Lys 
        195                 200                 205             


Gln Ala Ala Leu Asp Pro Phe Ile Leu Leu Asn Leu Leu Pro Asn Ser 
    210                 215                 220                 


Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys 
225                 230                 235                 240 


Thr Asp Thr Val Asp Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser 
                245                 250                 255     


Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser 
            260                 265                 270         


Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln 
        275                 280                 285             


Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu 
    290                 295                 300                 


Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala 
305                 310                 315                 320 


Asp Pro Glu Asn Tyr Thr Ser Leu Leu Val Thr Trp Glu Arg Pro Arg 
                325                 330                 335     


Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Gln 
            340                 345                 350         


Leu Asp Gly Glu Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr 
        355                 360                 365             


Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Leu Pro Asn Met Ser Tyr 
    370                 375                 380                 


Val Leu Gln Ile Val Ala Ile Cys Thr Asn Gly Leu Tyr Gly Lys Tyr 
385                 390                 395                 400 


Ser Asp Gln Leu Ile Val Asp Met Pro Thr Asp Asn Pro Glu Leu Asp 
                405                 410                 415     


Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Glu 
            420                 425                 430         


Glu Gly Lys Asp Ile Glu Glu Gly Ala Ile Val Asn Pro Gly Arg Asp 
        435                 440                 445             


Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Ile Ser Thr Thr 
    450                 455                 460                 


Thr His Tyr Asn Arg Ile Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn 
465                 470                 475                 480 


Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Gly Asp Val Pro 
                485                 490                 495     


Asn Thr Ser Leu Asn Ser Thr Ser Gln Pro Val Thr Lys Leu Ala Thr 
            500                 505                 510         


Glu Lys Asp Ile Ser Leu Thr Ser Gln Thr Val Thr Glu Leu Pro Pro 
        515                 520                 525             


His Thr Val Glu Gly Thr Ser Ala Ser Leu Asn Asp Gly Ser Lys Thr 
    530                 535                 540                 


Val Leu Arg Ser Pro His Met Asn Leu Ser Gly Thr Ala Glu Ser Leu 
545                 550                 555                 560 


Asn Thr Val Ser Ile Thr Glu Tyr Glu Glu Glu Ser Leu Leu Thr Ser 
                565                 570                 575     


Phe Lys Leu Asp Thr Gly Ala Glu Asp Ser Ser Gly Ser Ser Pro Ala 
            580                 585                 590         


Thr Ser Ala Ile Pro Phe Ile Ser Glu Asn Ile Ser Gln Gly Tyr Ile 
        595                 600                 605             


Phe Ser Ser Glu Asn Pro Glu Thr Ile Thr Tyr Asp Val Leu Ile Pro 
    610                 615                 620                 


Glu Ser Ala Arg Asn Ala Ser Glu Asp Ser Thr Ser Ser Gly Ser Glu 
625                 630                 635                 640 


Glu Ser Leu Lys Asp Pro Ser Met Glu Gly Asn Val Trp Phe Pro Ser 
                645                 650                 655     


Ser Thr Asp Ile Thr Ala Gln Pro Asp Val Gly Ser Gly Arg Glu Ser 
            660                 665                 670         


Phe Leu Gln Thr Asn Tyr Thr Glu Ile Arg Val Asp Glu Ser Glu Lys 
        675                 680                 685             


Thr Thr Lys Ser Phe Ser Ala Gly Pro Val Met Ser Gln Gly Pro Ser 
    690                 695                 700                 


Val Thr Asp Leu Glu Met Pro His Tyr Ser Thr Phe Ala Tyr Phe Pro 
705                 710                 715                 720 


Thr Glu Val Thr Pro His Ala Phe Thr Pro Ser Ser Arg Gln Gln Asp 
                725                 730                 735     


Leu Val Ser Thr Val Asn Val Val Tyr Ser Gln Thr Thr Gln Pro Val 
            740                 745                 750         


Tyr Asn Glu Ala Ser Asn Ser Ser His Glu Ser Arg Ile Gly Leu Ala 
        755                 760                 765             


Glu Gly Leu Glu Ser Glu Lys Lys Ala Val Ile Pro Leu Val Ile Val 
    770                 775                 780                 


Ser Ala Leu Thr Phe Ile Cys Leu Val Val Leu Val Gly Ile Leu Ile 
785                 790                 795                 800 


Tyr Trp Arg Lys Cys Phe Gln Thr Ala His Phe Tyr Leu Glu Asp Ser 
                805                 810                 815     


Thr Ser Pro Arg Val Ile Ser Thr Pro Pro Thr Pro Ile Phe Pro Ile 
            820                 825                 830         


Ser Asp Asp Val Gly Ala Ile Pro Ile Lys His Phe Pro Lys His Val 
        835                 840                 845             


Ala Asp Leu His Ala Ser Ser Gly Phe Thr Glu Glu Phe Glu Thr Leu 
    850                 855                 860                 


Lys Glu Phe Tyr Gln Glu Val Gln Ser Cys Thr Val Asp Leu Gly Ile 
865                 870                 875                 880 


Thr Ala Asp Ser Ser Asn His Pro Asp Asn Lys His Lys Asn Arg Tyr 
                885                 890                 895     


Ile Asn Ile Val Ala Tyr Asp His Ser Arg Val Lys Leu Ala Gln Leu 
            900                 905                 910         


Ala Glu Lys Asp Gly Lys Leu Thr Asp Tyr Ile Asn Ala Asn Tyr Val 
        915                 920                 925             


Asp Gly Tyr Asn Arg Pro Lys Ala Tyr Ile Ala Ala Gln Gly Pro Leu 
    930                 935                 940                 


Lys Ser Thr Ala Glu Asp Phe Trp Arg Met Ile Trp Glu His Asn Val 
945                 950                 955                 960 


Glu Val Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys 
                965                 970                 975     


Cys Asp Gln Tyr Trp Pro Ala Asp Gly Ser Glu Glu Tyr Gly Asn Phe 
            980                 985                 990         


Leu Val Thr Gln Lys Ser Val Gln  Val Leu Ala Tyr Tyr  Thr Val Arg 
        995                 1000                 1005             


Asn Phe  Thr Leu Arg Asn Thr  Lys Ile Lys Lys Gly  Ser Gln Lys 
    1010                 1015                 1020             


Gly Arg  Pro Ser Gly Arg Val  Val Thr Gln Tyr His  Tyr Thr Gln 
    1025                 1030                 1035             


Trp Pro  Asp Met Gly Val Pro  Glu Tyr Ser Leu Pro  Val Leu Thr 
    1040                 1045                 1050             


Phe Val  Arg Lys Ala Ala Tyr  Ala Lys Arg His Ala  Val Gly Pro 
    1055                 1060                 1065             


Val Val  Val His Cys Ser Ala  Gly Val Gly Arg Thr  Gly Thr Tyr 
    1070                 1075                 1080             


Ile Val  Leu Asp Ser Met Leu  Gln Gln Ile Gln His  Glu Gly Thr 
    1085                 1090                 1095             


Val Asn  Ile Phe Gly Phe Leu  Lys His Ile Arg Ser  Gln Arg Asn 
    1100                 1105                 1110             


Tyr Leu  Val Gln Thr Glu Glu  Gln Tyr Val Phe Ile  His Asp Thr 
    1115                 1120                 1125             


Leu Val  Glu Ala Ile Leu Ser  Lys Glu Thr Glu Val  Leu Asp Ser 
    1130                 1135                 1140             


His Ile  His Ala Tyr Val Asn  Ala Leu Leu Ile Pro  Gly Pro Ala 
    1145                 1150                 1155             


Gly Lys  Thr Lys Leu Glu Lys  Gln Phe Gln Leu Leu  Ser Gln Ser 
    1160                 1165                 1170             


Asn Ile  Gln Gln Ser Asp Tyr  Ser Ala Ala Leu Lys  Gln Cys Asn 
    1175                 1180                 1185             


Arg Glu  Lys Asn Arg Thr Ser  Ser Ile Ile Pro Val  Glu Arg Ser 
    1190                 1195                 1200             


Arg Val  Gly Ile Ser Ser Leu  Ser Gly Glu Gly Thr  Asp Tyr Ile 
    1205                 1210                 1215             


Asn Ala  Ser Tyr Ile Met Gly  Tyr Tyr Gln Ser Asn  Glu Phe Ile 
    1220                 1225                 1230             


Ile Thr  Gln His Pro Leu Leu  His Thr Ile Lys Asp  Phe Trp Arg 
    1235                 1240                 1245             


Met Ile  Trp Asp His Asn Ala  Gln Leu Val Val Met  Ile Pro Asp 
    1250                 1255                 1260             


Gly Gln  Asn Met Ala Glu Asp  Glu Phe Val Tyr Trp  Pro Asn Lys 
    1265                 1270                 1275             


Asp Glu  Pro Ile Asn Cys Glu  Ser Phe Lys Val Thr  Leu Met Ala 
    1280                 1285                 1290             


Glu Glu  His Lys Cys Leu Ser  Asn Glu Glu Lys Leu  Ile Ile Gln 
    1295                 1300                 1305             


Asp Phe  Ile Leu Glu Ala Thr  Gln Asp Asp Tyr Val  Leu Glu Val 
    1310                 1315                 1320             


Arg His  Phe Gln Cys Pro Lys  Trp Pro Asn Pro Asp  Ser Pro Ile 
    1325                 1330                 1335             


Ser Lys  Thr Phe Glu Leu Ile  Ser Val Ile Lys Glu  Glu Ala Ala 
    1340                 1345                 1350             


Asn Arg  Asp Gly Pro Met Ile  Val His Asp Glu His  Gly Gly Val 
    1355                 1360                 1365             


Thr Ala  Gly Thr Phe Cys Ala  Leu Thr Thr Leu Met  His Gln Leu 
    1370                 1375                 1380             


Glu Lys  Glu Asn Ser Val Asp  Val Tyr Gln Val Ala  Lys Met Ile 
    1385                 1390                 1395             


Asn Leu  Met Arg Pro Gly Val  Phe Ala Asp Ile Glu  Gln Tyr Gln 
    1400                 1405                 1410             


Phe Leu  Tyr Lys Val Ile Leu  Ser Leu Val Ser Thr  Arg Gln Glu 
    1415                 1420                 1425             


Glu Asn  Pro Ser Thr Ser Leu  Asp Ser Asn Gly Ala  Ala Leu Pro 
    1430                 1435                 1440             


Asp Gly  Asn Ile Ala Glu Ser  Leu Glu Ser Leu Val  
    1445                 1450                 1455 


<210>  431
<211>  1448
<212>  PRT
<213>  Homo sapiens

<400>  431

Met Arg Ile Leu Lys Arg Phe Leu Ala Cys Ile Gln Leu Leu Cys Val 
1               5                   10                  15      


Cys Arg Leu Asp Trp Ala Asn Gly Tyr Tyr Arg Gln Gln Arg Lys Leu 
            20                  25                  30          


Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn 
        35                  40                  45              


Trp Gly Lys Lys Tyr Pro Thr Cys Asn Ser Pro Lys Gln Ser Pro Ile 
    50                  55                  60                  


Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu 
65                  70                  75                  80  


Lys Phe Gln Gly Trp Asp Lys Thr Ser Leu Glu Asn Thr Phe Ile His 
                85                  90                  95      


Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Arg Val 
            100                 105                 110         


Ser Gly Gly Val Ser Glu Met Val Phe Lys Ala Ser Lys Ile Thr Phe 
        115                 120                 125             


His Trp Gly Lys Cys Asn Met Ser Ser Asp Gly Ser Glu His Ser Leu 
    130                 135                 140                 


Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala 
145                 150                 155                 160 


Asp Arg Phe Ser Ser Phe Glu Glu Ala Val Lys Gly Lys Gly Lys Leu 
                165                 170                 175     


Arg Ala Leu Ser Ile Leu Phe Glu Val Gly Thr Glu Glu Asn Leu Asp 
            180                 185                 190         


Phe Lys Ala Ile Ile Asp Gly Val Glu Ser Val Ser Arg Phe Gly Lys 
        195                 200                 205             


Gln Ala Ala Leu Asp Pro Phe Ile Leu Leu Asn Leu Leu Pro Asn Ser 
    210                 215                 220                 


Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys 
225                 230                 235                 240 


Thr Asp Thr Val Asp Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser 
                245                 250                 255     


Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser 
            260                 265                 270         


Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln 
        275                 280                 285             


Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu 
    290                 295                 300                 


Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala 
305                 310                 315                 320 


Asp Pro Glu Asn Tyr Thr Ser Leu Leu Val Thr Trp Glu Arg Pro Arg 
                325                 330                 335     


Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Gln 
            340                 345                 350         


Leu Asp Gly Glu Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr 
        355                 360                 365             


Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Leu Pro Asn Met Ser Tyr 
    370                 375                 380                 


Val Leu Gln Ile Val Ala Ile Cys Thr Asn Gly Leu Tyr Gly Lys Tyr 
385                 390                 395                 400 


Ser Asp Gln Leu Ile Val Asp Met Pro Thr Asp Asn Pro Glu Leu Asp 
                405                 410                 415     


Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Glu 
            420                 425                 430         


Glu Gly Lys Asp Ile Glu Glu Gly Ala Ile Val Asn Pro Gly Arg Asp 
        435                 440                 445             


Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Ile Ser Thr Thr 
    450                 455                 460                 


Thr His Tyr Asn Arg Ile Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn 
465                 470                 475                 480 


Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Gly Asp Val Pro 
                485                 490                 495     


Asn Thr Ser Leu Asn Ser Thr Ser Gln Pro Val Thr Lys Leu Ala Thr 
            500                 505                 510         


Glu Lys Asp Ile Ser Leu Thr Ser Gln Thr Val Thr Glu Leu Pro Pro 
        515                 520                 525             


His Thr Val Glu Gly Thr Ser Ala Ser Leu Asn Asp Gly Ser Lys Thr 
    530                 535                 540                 


Val Leu Arg Ser Pro His Met Asn Leu Ser Gly Thr Ala Glu Ser Leu 
545                 550                 555                 560 


Asn Thr Val Ser Ile Thr Glu Tyr Glu Glu Glu Ser Leu Leu Thr Ser 
                565                 570                 575     


Phe Lys Leu Asp Thr Gly Ala Glu Asp Ser Ser Gly Ser Ser Pro Ala 
            580                 585                 590         


Thr Ser Ala Ile Pro Phe Ile Ser Glu Asn Ile Ser Gln Gly Tyr Ile 
        595                 600                 605             


Phe Ser Ser Glu Asn Pro Glu Thr Ile Thr Tyr Asp Val Leu Ile Pro 
    610                 615                 620                 


Glu Ser Ala Arg Asn Ala Ser Glu Asp Ser Thr Ser Ser Gly Ser Glu 
625                 630                 635                 640 


Glu Ser Leu Lys Asp Pro Ser Met Glu Gly Asn Val Trp Phe Pro Ser 
                645                 650                 655     


Ser Thr Asp Ile Thr Ala Gln Pro Asp Val Gly Ser Gly Arg Glu Ser 
            660                 665                 670         


Phe Leu Gln Thr Asn Tyr Thr Glu Ile Arg Val Asp Glu Ser Glu Lys 
        675                 680                 685             


Thr Thr Lys Ser Phe Ser Ala Gly Pro Val Met Ser Gln Gly Pro Ser 
    690                 695                 700                 


Val Thr Asp Leu Glu Met Pro His Tyr Ser Thr Phe Ala Tyr Phe Pro 
705                 710                 715                 720 


Thr Glu Val Thr Pro His Ala Phe Thr Pro Ser Ser Arg Gln Gln Asp 
                725                 730                 735     


Leu Val Ser Thr Val Asn Val Val Tyr Ser Gln Thr Thr Gln Pro Val 
            740                 745                 750         


Tyr Asn Glu Ala Ser Asn Ser Ser His Glu Ser Arg Ile Gly Leu Ala 
        755                 760                 765             


Glu Gly Leu Glu Ser Glu Lys Lys Ala Val Ile Pro Leu Val Ile Val 
    770                 775                 780                 


Ser Ala Leu Thr Phe Ile Cys Leu Val Val Leu Val Gly Ile Leu Ile 
785                 790                 795                 800 


Tyr Trp Arg Lys Cys Phe Gln Thr Ala His Phe Tyr Leu Glu Asp Ser 
                805                 810                 815     


Thr Ser Pro Arg Val Ile Ser Thr Pro Pro Thr Pro Ile Phe Pro Ile 
            820                 825                 830         


Ser Asp Asp Val Gly Ala Ile Pro Ile Lys His Phe Pro Lys His Val 
        835                 840                 845             


Ala Asp Leu His Ala Ser Ser Gly Phe Thr Glu Glu Phe Glu Glu Val 
    850                 855                 860                 


Gln Ser Cys Thr Val Asp Leu Gly Ile Thr Ala Asp Ser Ser Asn His 
865                 870                 875                 880 


Pro Asp Asn Lys His Lys Asn Arg Tyr Ile Asn Ile Val Ala Tyr Asp 
                885                 890                 895     


His Ser Arg Val Lys Leu Ala Gln Leu Ala Glu Lys Asp Gly Lys Leu 
            900                 905                 910         


Thr Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Asn Arg Pro Lys 
        915                 920                 925             


Ala Tyr Ile Ala Ala Gln Gly Pro Leu Lys Ser Thr Ala Glu Asp Phe 
    930                 935                 940                 


Trp Arg Met Ile Trp Glu His Asn Val Glu Val Ile Val Met Ile Thr 
945                 950                 955                 960 


Asn Leu Val Glu Lys Gly Arg Arg Lys Cys Asp Gln Tyr Trp Pro Ala 
                965                 970                 975     


Asp Gly Ser Glu Glu Tyr Gly Asn Phe Leu Val Thr Gln Lys Ser Val 
            980                 985                 990         


Gln Val Leu Ala Tyr Tyr Thr Val  Arg Asn Phe Thr Leu  Arg Asn Thr 
        995                 1000                 1005             


Lys Ile  Lys Lys Gly Ser Gln  Lys Gly Arg Pro Ser  Gly Arg Val 
    1010                 1015                 1020             


Val Thr  Gln Tyr His Tyr Thr  Gln Trp Pro Asp Met  Gly Val Pro 
    1025                 1030                 1035             


Glu Tyr  Ser Leu Pro Val Leu  Thr Phe Val Arg Lys  Ala Ala Tyr 
    1040                 1045                 1050             


Ala Lys  Arg His Ala Val Gly  Pro Val Val Val His  Cys Ser Ala 
    1055                 1060                 1065             


Gly Val  Gly Arg Thr Gly Thr  Tyr Ile Val Leu Asp  Ser Met Leu 
    1070                 1075                 1080             


Gln Gln  Ile Gln His Glu Gly  Thr Val Asn Ile Phe  Gly Phe Leu 
    1085                 1090                 1095             


Lys His  Ile Arg Ser Gln Arg  Asn Tyr Leu Val Gln  Thr Glu Glu 
    1100                 1105                 1110             


Gln Tyr  Val Phe Ile His Asp  Thr Leu Val Glu Ala  Ile Leu Ser 
    1115                 1120                 1125             


Lys Glu  Thr Glu Val Leu Asp  Ser His Ile His Ala  Tyr Val Asn 
    1130                 1135                 1140             


Ala Leu  Leu Ile Pro Gly Pro  Ala Gly Lys Thr Lys  Leu Glu Lys 
    1145                 1150                 1155             


Gln Phe  Gln Leu Leu Ser Gln  Ser Asn Ile Gln Gln  Ser Asp Tyr 
    1160                 1165                 1170             


Ser Ala  Ala Leu Lys Gln Cys  Asn Arg Glu Lys Asn  Arg Thr Ser 
    1175                 1180                 1185             


Ser Ile  Ile Pro Val Glu Arg  Ser Arg Val Gly Ile  Ser Ser Leu 
    1190                 1195                 1200             


Ser Gly  Glu Gly Thr Asp Tyr  Ile Asn Ala Ser Tyr  Ile Met Gly 
    1205                 1210                 1215             


Tyr Tyr  Gln Ser Asn Glu Phe  Ile Ile Thr Gln His  Pro Leu Leu 
    1220                 1225                 1230             


His Thr  Ile Lys Asp Phe Trp  Arg Met Ile Trp Asp  His Asn Ala 
    1235                 1240                 1245             


Gln Leu  Val Val Met Ile Pro  Asp Gly Gln Asn Met  Ala Glu Asp 
    1250                 1255                 1260             


Glu Phe  Val Tyr Trp Pro Asn  Lys Asp Glu Pro Ile  Asn Cys Glu 
    1265                 1270                 1275             


Ser Phe  Lys Val Thr Leu Met  Ala Glu Glu His Lys  Cys Leu Ser 
    1280                 1285                 1290             


Asn Glu  Glu Lys Leu Ile Ile  Gln Asp Phe Ile Leu  Glu Ala Thr 
    1295                 1300                 1305             


Gln Asp  Asp Tyr Val Leu Glu  Val Arg His Phe Gln  Cys Pro Lys 
    1310                 1315                 1320             


Trp Pro  Asn Pro Asp Ser Pro  Ile Ser Lys Thr Phe  Glu Leu Ile 
    1325                 1330                 1335             


Ser Val  Ile Lys Glu Glu Ala  Ala Asn Arg Asp Gly  Pro Met Ile 
    1340                 1345                 1350             


Val His  Asp Glu His Gly Gly  Val Thr Ala Gly Thr  Phe Cys Ala 
    1355                 1360                 1365             


Leu Thr  Thr Leu Met His Gln  Leu Glu Lys Glu Asn  Ser Val Asp 
    1370                 1375                 1380             


Val Tyr  Gln Val Ala Lys Met  Ile Asn Leu Met Arg  Pro Gly Val 
    1385                 1390                 1395             


Phe Ala  Asp Ile Glu Gln Tyr  Gln Phe Leu Tyr Lys  Val Ile Leu 
    1400                 1405                 1410             


Ser Leu  Val Ser Thr Arg Gln  Glu Glu Asn Pro Ser  Thr Ser Leu 
    1415                 1420                 1425             


Asp Ser  Asn Gly Ala Ala Leu  Pro Asp Gly Asn Ile  Ala Glu Ser 
    1430                 1435                 1440             


Leu Glu  Ser Leu Val 
    1445             


<210>  432
<211>  2315
<212>  PRT
<213>  Homo sapiens

<400>  432

Met Arg Ile Leu Lys Arg Phe Leu Ala Cys Ile Gln Leu Leu Cys Val 
1               5                   10                  15      


Cys Arg Leu Asp Trp Ala Asn Gly Tyr Tyr Arg Gln Gln Arg Lys Leu 
            20                  25                  30          


Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn 
        35                  40                  45              


Trp Gly Lys Lys Tyr Pro Thr Cys Asn Ser Pro Lys Gln Ser Pro Ile 
    50                  55                  60                  


Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu 
65                  70                  75                  80  


Lys Phe Gln Gly Trp Asp Lys Thr Ser Leu Glu Asn Thr Phe Ile His 
                85                  90                  95      


Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Arg Val 
            100                 105                 110         


Ser Gly Gly Val Ser Glu Met Val Phe Lys Ala Ser Lys Ile Thr Phe 
        115                 120                 125             


His Trp Gly Lys Cys Asn Met Ser Ser Asp Gly Ser Glu His Ser Leu 
    130                 135                 140                 


Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala 
145                 150                 155                 160 


Asp Arg Phe Ser Ser Phe Glu Glu Ala Val Lys Gly Lys Gly Lys Leu 
                165                 170                 175     


Arg Ala Leu Ser Ile Leu Phe Glu Val Gly Thr Glu Glu Asn Leu Asp 
            180                 185                 190         


Phe Lys Ala Ile Ile Asp Gly Val Glu Ser Val Ser Arg Phe Gly Lys 
        195                 200                 205             


Gln Ala Ala Leu Asp Pro Phe Ile Leu Leu Asn Leu Leu Pro Asn Ser 
    210                 215                 220                 


Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys 
225                 230                 235                 240 


Thr Asp Thr Val Asp Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser 
                245                 250                 255     


Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser 
            260                 265                 270         


Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln 
        275                 280                 285             


Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu 
    290                 295                 300                 


Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala 
305                 310                 315                 320 


Asp Pro Glu Asn Tyr Thr Ser Leu Leu Val Thr Trp Glu Arg Pro Arg 
                325                 330                 335     


Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Gln 
            340                 345                 350         


Leu Asp Gly Glu Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr 
        355                 360                 365             


Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Leu Pro Asn Met Ser Tyr 
    370                 375                 380                 


Val Leu Gln Ile Val Ala Ile Cys Thr Asn Gly Leu Tyr Gly Lys Tyr 
385                 390                 395                 400 


Ser Asp Gln Leu Ile Val Asp Met Pro Thr Asp Asn Pro Glu Leu Asp 
                405                 410                 415     


Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Glu 
            420                 425                 430         


Glu Gly Lys Asp Ile Glu Glu Gly Ala Ile Val Asn Pro Gly Arg Asp 
        435                 440                 445             


Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Ile Ser Thr Thr 
    450                 455                 460                 


Thr His Tyr Asn Arg Ile Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn 
465                 470                 475                 480 


Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Gly Asp Val Pro 
                485                 490                 495     


Asn Thr Ser Leu Asn Ser Thr Ser Gln Pro Val Thr Lys Leu Ala Thr 
            500                 505                 510         


Glu Lys Asp Ile Ser Leu Thr Ser Gln Thr Val Thr Glu Leu Pro Pro 
        515                 520                 525             


His Thr Val Glu Gly Thr Ser Ala Ser Leu Asn Asp Gly Ser Lys Thr 
    530                 535                 540                 


Val Leu Arg Ser Pro His Met Asn Leu Ser Gly Thr Ala Glu Ser Leu 
545                 550                 555                 560 


Asn Thr Val Ser Ile Thr Glu Tyr Glu Glu Glu Ser Leu Leu Thr Ser 
                565                 570                 575     


Phe Lys Leu Asp Thr Gly Ala Glu Asp Ser Ser Gly Ser Ser Pro Ala 
            580                 585                 590         


Thr Ser Ala Ile Pro Phe Ile Ser Glu Asn Ile Ser Gln Gly Tyr Ile 
        595                 600                 605             


Phe Ser Ser Glu Asn Pro Glu Thr Ile Thr Tyr Asp Val Leu Ile Pro 
    610                 615                 620                 


Glu Ser Ala Arg Asn Ala Ser Glu Asp Ser Thr Ser Ser Gly Ser Glu 
625                 630                 635                 640 


Glu Ser Leu Lys Asp Pro Ser Met Glu Gly Asn Val Trp Phe Pro Ser 
                645                 650                 655     


Ser Thr Asp Ile Thr Ala Gln Pro Asp Val Gly Ser Gly Arg Glu Ser 
            660                 665                 670         


Phe Leu Gln Thr Asn Tyr Thr Glu Ile Arg Val Asp Glu Ser Glu Lys 
        675                 680                 685             


Thr Thr Lys Ser Phe Ser Ala Gly Pro Val Met Ser Gln Gly Pro Ser 
    690                 695                 700                 


Val Thr Asp Leu Glu Met Pro His Tyr Ser Thr Phe Ala Tyr Phe Pro 
705                 710                 715                 720 


Thr Glu Val Thr Pro His Ala Phe Thr Pro Ser Ser Arg Gln Gln Asp 
                725                 730                 735     


Leu Val Ser Thr Val Asn Val Val Tyr Ser Gln Thr Thr Gln Pro Val 
            740                 745                 750         


Tyr Asn Gly Glu Thr Pro Leu Gln Pro Ser Tyr Ser Ser Glu Val Phe 
        755                 760                 765             


Pro Leu Val Thr Pro Leu Leu Leu Asp Asn Gln Ile Leu Asn Thr Thr 
    770                 775                 780                 


Pro Ala Ala Ser Ser Ser Asp Ser Ala Leu His Ala Thr Pro Val Phe 
785                 790                 795                 800 


Pro Ser Val Asp Val Ser Phe Glu Ser Ile Leu Ser Ser Tyr Asp Gly 
                805                 810                 815     


Ala Pro Leu Leu Pro Phe Ser Ser Ala Ser Phe Ser Ser Glu Leu Phe 
            820                 825                 830         


Arg His Leu His Thr Val Ser Gln Ile Leu Pro Gln Val Thr Ser Ala 
        835                 840                 845             


Thr Glu Ser Asp Lys Val Pro Leu His Ala Ser Leu Pro Val Ala Gly 
    850                 855                 860                 


Gly Asp Leu Leu Leu Glu Pro Ser Leu Ala Gln Tyr Ser Asp Val Leu 
865                 870                 875                 880 


Ser Thr Thr His Ala Ala Ser Glu Thr Leu Glu Phe Gly Ser Glu Ser 
                885                 890                 895     


Gly Val Leu Tyr Lys Thr Leu Met Phe Ser Gln Val Glu Pro Pro Ser 
            900                 905                 910         


Ser Asp Ala Met Met His Ala Arg Ser Ser Gly Pro Glu Pro Ser Tyr 
        915                 920                 925             


Ala Leu Ser Asp Asn Glu Gly Ser Gln His Ile Phe Thr Val Ser Tyr 
    930                 935                 940                 


Ser Ser Ala Ile Pro Val His Asp Ser Val Gly Val Thr Tyr Gln Gly 
945                 950                 955                 960 


Ser Leu Phe Ser Gly Pro Ser His Ile Pro Ile Pro Lys Ser Ser Leu 
                965                 970                 975     


Ile Thr Pro Thr Ala Ser Leu Leu Gln Pro Thr His Ala Leu Ser Gly 
            980                 985                 990         


Asp Gly Glu Trp Ser Gly Ala Ser  Ser Asp Ser Glu Phe  Leu Leu Pro 
        995                 1000                 1005             


Asp Thr  Asp Gly Leu Thr Ala  Leu Asn Ile Ser Ser  Pro Val Ser 
    1010                 1015                 1020             


Val Ala  Glu Phe Thr Tyr Thr  Thr Ser Val Phe Gly  Asp Asp Asn 
    1025                 1030                 1035             


Lys Ala  Leu Ser Lys Ser Glu  Ile Ile Tyr Gly Asn  Glu Thr Glu 
    1040                 1045                 1050             


Leu Gln  Ile Pro Ser Phe Asn  Glu Met Val Tyr Pro  Ser Glu Ser 
    1055                 1060                 1065             


Thr Val  Met Pro Asn Met Tyr  Asp Asn Val Asn Lys  Leu Asn Ala 
    1070                 1075                 1080             


Ser Leu  Gln Glu Thr Ser Val  Ser Ile Ser Ser Thr  Lys Gly Met 
    1085                 1090                 1095             


Phe Pro  Gly Ser Leu Ala His  Thr Thr Thr Lys Val  Phe Asp His 
    1100                 1105                 1110             


Glu Ile  Ser Gln Val Pro Glu  Asn Asn Phe Ser Val  Gln Pro Thr 
    1115                 1120                 1125             


His Thr  Val Ser Gln Ala Ser  Gly Asp Thr Ser Leu  Lys Pro Val 
    1130                 1135                 1140             


Leu Ser  Ala Asn Ser Glu Pro  Ala Ser Ser Asp Pro  Ala Ser Ser 
    1145                 1150                 1155             


Glu Met  Leu Ser Pro Ser Thr  Gln Leu Leu Phe Tyr  Glu Thr Ser 
    1160                 1165                 1170             


Ala Ser  Phe Ser Thr Glu Val  Leu Leu Gln Pro Ser  Phe Gln Ala 
    1175                 1180                 1185             


Ser Asp  Val Asp Thr Leu Leu  Lys Thr Val Leu Pro  Ala Val Pro 
    1190                 1195                 1200             


Ser Asp  Pro Ile Leu Val Glu  Thr Pro Lys Val Asp  Lys Ile Ser 
    1205                 1210                 1215             


Ser Thr  Met Leu His Leu Ile  Val Ser Asn Ser Ala  Ser Ser Glu 
    1220                 1225                 1230             


Asn Met  Leu His Ser Thr Ser  Val Pro Val Phe Asp  Val Ser Pro 
    1235                 1240                 1245             


Thr Ser  His Met His Ser Ala  Ser Leu Gln Gly Leu  Thr Ile Ser 
    1250                 1255                 1260             


Tyr Ala  Ser Glu Lys Tyr Glu  Pro Val Leu Leu Lys  Ser Glu Ser 
    1265                 1270                 1275             


Ser His  Gln Val Val Pro Ser  Leu Tyr Ser Asn Asp  Glu Leu Phe 
    1280                 1285                 1290             


Gln Thr  Ala Asn Leu Glu Ile  Asn Gln Ala His Pro  Pro Lys Gly 
    1295                 1300                 1305             


Arg His  Val Phe Ala Thr Pro  Val Leu Ser Ile Asp  Glu Pro Leu 
    1310                 1315                 1320             


Asn Thr  Leu Ile Asn Lys Leu  Ile His Ser Asp Glu  Ile Leu Thr 
    1325                 1330                 1335             


Ser Thr  Lys Ser Ser Val Thr  Gly Lys Val Phe Ala  Gly Ile Pro 
    1340                 1345                 1350             


Thr Val  Ala Ser Asp Thr Phe  Val Ser Thr Asp His  Ser Val Pro 
    1355                 1360                 1365             


Ile Gly  Asn Gly His Val Ala  Ile Thr Ala Val Ser  Pro His Arg 
    1370                 1375                 1380             


Asp Gly  Ser Val Thr Ser Thr  Lys Leu Leu Phe Pro  Ser Lys Ala 
    1385                 1390                 1395             


Thr Ser  Glu Leu Ser His Ser  Ala Lys Ser Asp Ala  Gly Leu Val 
    1400                 1405                 1410             


Gly Gly  Gly Glu Asp Gly Asp  Thr Asp Asp Asp Gly  Asp Asp Asp 
    1415                 1420                 1425             


Asp Asp  Asp Arg Gly Ser Asp  Gly Leu Ser Ile His  Lys Cys Met 
    1430                 1435                 1440             


Ser Cys  Ser Ser Tyr Arg Glu  Ser Gln Glu Lys Val  Met Asn Asp 
    1445                 1450                 1455             


Ser Asp  Thr His Glu Asn Ser  Leu Met Asp Gln Asn  Asn Pro Ile 
    1460                 1465                 1470             


Ser Tyr  Ser Leu Ser Glu Asn  Ser Glu Glu Asp Asn  Arg Val Thr 
    1475                 1480                 1485             


Ser Val  Ser Ser Asp Ser Gln  Thr Gly Met Asp Arg  Ser Pro Gly 
    1490                 1495                 1500             


Lys Ser  Pro Ser Ala Asn Gly  Leu Ser Gln Lys His  Asn Asp Gly 
    1505                 1510                 1515             


Lys Glu  Glu Asn Asp Ile Gln  Thr Gly Ser Ala Leu  Leu Pro Leu 
    1520                 1525                 1530             


Ser Pro  Glu Ser Lys Ala Trp  Ala Val Leu Thr Ser  Asp Glu Glu 
    1535                 1540                 1545             


Ser Gly  Ser Gly Gln Gly Thr  Ser Asp Ser Leu Asn  Glu Asn Glu 
    1550                 1555                 1560             


Thr Ser  Thr Asp Phe Ser Phe  Ala Asp Thr Asn Glu  Lys Asp Ala 
    1565                 1570                 1575             


Asp Gly  Ile Leu Ala Ala Gly  Asp Ser Glu Ile Thr  Pro Gly Phe 
    1580                 1585                 1590             


Pro Gln  Ser Pro Thr Ser Ser  Val Thr Ser Glu Asn  Ser Glu Val 
    1595                 1600                 1605             


Phe His  Val Ser Glu Ala Glu  Ala Ser Asn Ser Ser  His Glu Ser 
    1610                 1615                 1620             


Arg Ile  Gly Leu Ala Glu Gly  Leu Glu Ser Glu Lys  Lys Ala Val 
    1625                 1630                 1635             


Ile Pro  Leu Val Ile Val Ser  Ala Leu Thr Phe Ile  Cys Leu Val 
    1640                 1645                 1650             


Val Leu  Val Gly Ile Leu Ile  Tyr Trp Arg Lys Cys  Phe Gln Thr 
    1655                 1660                 1665             


Ala His  Phe Tyr Leu Glu Asp  Ser Thr Ser Pro Arg  Val Ile Ser 
    1670                 1675                 1680             


Thr Pro  Pro Thr Pro Ile Phe  Pro Ile Ser Asp Asp  Val Gly Ala 
    1685                 1690                 1695             


Ile Pro  Ile Lys His Phe Pro  Lys His Val Ala Asp  Leu His Ala 
    1700                 1705                 1710             


Ser Ser  Gly Phe Thr Glu Glu  Phe Glu Thr Leu Lys  Glu Phe Tyr 
    1715                 1720                 1725             


Gln Glu  Val Gln Ser Cys Thr  Val Asp Leu Gly Ile  Thr Ala Asp 
    1730                 1735                 1740             


Ser Ser  Asn His Pro Asp Asn  Lys His Lys Asn Arg  Tyr Ile Asn 
    1745                 1750                 1755             


Ile Val  Ala Tyr Asp His Ser  Arg Val Lys Leu Ala  Gln Leu Ala 
    1760                 1765                 1770             


Glu Lys  Asp Gly Lys Leu Thr  Asp Tyr Ile Asn Ala  Asn Tyr Val 
    1775                 1780                 1785             


Asp Gly  Tyr Asn Arg Pro Lys  Ala Tyr Ile Ala Ala  Gln Gly Pro 
    1790                 1795                 1800             


Leu Lys  Ser Thr Ala Glu Asp  Phe Trp Arg Met Ile  Trp Glu His 
    1805                 1810                 1815             


Asn Val  Glu Val Ile Val Met  Ile Thr Asn Leu Val  Glu Lys Gly 
    1820                 1825                 1830             


Arg Arg  Lys Cys Asp Gln Tyr  Trp Pro Ala Asp Gly  Ser Glu Glu 
    1835                 1840                 1845             


Tyr Gly  Asn Phe Leu Val Thr  Gln Lys Ser Val Gln  Val Leu Ala 
    1850                 1855                 1860             


Tyr Tyr  Thr Val Arg Asn Phe  Thr Leu Arg Asn Thr  Lys Ile Lys 
    1865                 1870                 1875             


Lys Gly  Ser Gln Lys Gly Arg  Pro Ser Gly Arg Val  Val Thr Gln 
    1880                 1885                 1890             


Tyr His  Tyr Thr Gln Trp Pro  Asp Met Gly Val Pro  Glu Tyr Ser 
    1895                 1900                 1905             


Leu Pro  Val Leu Thr Phe Val  Arg Lys Ala Ala Tyr  Ala Lys Arg 
    1910                 1915                 1920             


His Ala  Val Gly Pro Val Val  Val His Cys Ser Ala  Gly Val Gly 
    1925                 1930                 1935             


Arg Thr  Gly Thr Tyr Ile Val  Leu Asp Ser Met Leu  Gln Gln Ile 
    1940                 1945                 1950             


Gln His  Glu Gly Thr Val Asn  Ile Phe Gly Phe Leu  Lys His Ile 
    1955                 1960                 1965             


Arg Ser  Gln Arg Asn Tyr Leu  Val Gln Thr Glu Glu  Gln Tyr Val 
    1970                 1975                 1980             


Phe Ile  His Asp Thr Leu Val  Glu Ala Ile Leu Ser  Lys Glu Thr 
    1985                 1990                 1995             


Glu Val  Leu Asp Ser His Ile  His Ala Tyr Val Asn  Ala Leu Leu 
    2000                 2005                 2010             


Ile Pro  Gly Pro Ala Gly Lys  Thr Lys Leu Glu Lys  Gln Phe Gln 
    2015                 2020                 2025             


Leu Leu  Ser Gln Ser Asn Ile  Gln Gln Ser Asp Tyr  Ser Ala Ala 
    2030                 2035                 2040             


Leu Lys  Gln Cys Asn Arg Glu  Lys Asn Arg Thr Ser  Ser Ile Ile 
    2045                 2050                 2055             


Pro Val  Glu Arg Ser Arg Val  Gly Ile Ser Ser Leu  Ser Gly Glu 
    2060                 2065                 2070             


Gly Thr  Asp Tyr Ile Asn Ala  Ser Tyr Ile Met Gly  Tyr Tyr Gln 
    2075                 2080                 2085             


Ser Asn  Glu Phe Ile Ile Thr  Gln His Pro Leu Leu  His Thr Ile 
    2090                 2095                 2100             


Lys Asp  Phe Trp Arg Met Ile  Trp Asp His Asn Ala  Gln Leu Val 
    2105                 2110                 2115             


Val Met  Ile Pro Asp Gly Gln  Asn Met Ala Glu Asp  Glu Phe Val 
    2120                 2125                 2130             


Tyr Trp  Pro Asn Lys Asp Glu  Pro Ile Asn Cys Glu  Ser Phe Lys 
    2135                 2140                 2145             


Val Thr  Leu Met Ala Glu Glu  His Lys Cys Leu Ser  Asn Glu Glu 
    2150                 2155                 2160             


Lys Leu  Ile Ile Gln Asp Phe  Ile Leu Glu Ala Thr  Gln Asp Asp 
    2165                 2170                 2175             


Tyr Val  Leu Glu Val Arg His  Phe Gln Cys Pro Lys  Trp Pro Asn 
    2180                 2185                 2190             


Pro Asp  Ser Pro Ile Ser Lys  Thr Phe Glu Leu Ile  Ser Val Ile 
    2195                 2200                 2205             


Lys Glu  Glu Ala Ala Asn Arg  Asp Gly Pro Met Ile  Val His Asp 
    2210                 2215                 2220             


Glu His  Gly Gly Val Thr Ala  Gly Thr Phe Cys Ala  Leu Thr Thr 
    2225                 2230                 2235             


Leu Met  His Gln Leu Glu Lys  Glu Asn Ser Val Asp  Val Tyr Gln 
    2240                 2245                 2250             


Val Ala  Lys Met Ile Asn Leu  Met Arg Pro Gly Val  Phe Ala Asp 
    2255                 2260                 2265             


Ile Glu  Gln Tyr Gln Phe Leu  Tyr Lys Val Ile Leu  Ser Leu Val 
    2270                 2275                 2280             


Ser Thr  Arg Gln Glu Glu Asn  Pro Ser Thr Ser Leu  Asp Ser Asn 
    2285                 2290                 2295             


Gly Ala  Ala Leu Pro Asp Gly  Asn Ile Ala Glu Ser  Leu Glu Ser 
    2300                 2305                 2310             


Leu Val  
    2315 


<210>  433
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  433

Met Glu Thr Gly Ala Leu Arg Arg Pro Gln Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Cys Gly Gly Cys Pro Arg Ala Gly Gly Cys Asn Glu Thr Gly 
            20                  25                  30          


Met Leu Glu Arg Leu Pro Leu Cys Gly Lys Ala Phe Ala Asp Met Met 
        35                  40                  45              


Gly Lys Val Asp Val Trp Lys Trp Cys Asn Leu Ser Glu Phe Ile Val 
    50                  55                  60                  


Tyr Tyr Glu Ser Phe Thr Asn Cys Thr Glu Met Glu Ala Asn Val Val 
65                  70                  75                  80  


Gly Cys Tyr Trp Pro Asn Pro Leu Ala Gln Gly Phe Ile Thr Gly Ile 
                85                  90                  95      


His Arg Gln Phe Phe Ser Asn Cys Thr Val Asp Arg Val His Leu Glu 
            100                 105                 110         


Asp Pro Pro Asp Glu Val Leu Ile Pro Leu Ile Val Ile Pro Val Val 
        115                 120                 125             


Leu Thr Val Ala Met Ala Gly Leu Val Val Trp Arg Ser Lys Arg Thr 
    130                 135                 140                 


Asp Thr Leu Leu 
145             


<210>  434
<211>  1072
<212>  PRT
<213>  Homo sapiens

<400>  434

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Arg Ile  Ser His Ala 
    1055                 1060                 1065             


Phe Thr  Arg Phe 
    1070         


<210>  435
<211>  1114
<212>  PRT
<213>  Homo sapiens

<400>  435

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Met Ser  Asp Pro Asn 
    1055                 1060                 1065             


Trp Pro  Gly Glu Ser Pro Val  Pro Leu Thr Arg Ala  Asp Gly Thr 
    1070                 1075                 1080             


Asn Thr  Gly Phe Pro Arg Tyr  Pro Asn Asp Ser Val  Tyr Ala Asn 
    1085                 1090                 1095             


Trp Met  Leu Ser Pro Ser Ala  Ala Lys Leu Met Asp  Thr Phe Asp 
    1100                 1105                 1110             


Ser 
    


<210>  436
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  436

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Gly Lys 
385                 390             


<210>  437
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  437

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  438
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  438

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Pro Glu Thr Ala Ala Arg Trp Gly Phe Cys Thr Ser Trp Ser Pro Ala 
385                 390                 395                 400 


Ser Gln Phe His Trp Ser Ser Leu Ala Phe Ser Ser Trp Phe Ala Cys 
                405                 410                 415     


Ala Gly Ile Ser Arg Arg His Leu Arg Pro His Arg Ser Gly Asp Ser 
            420                 425                 430         


<210>  439
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  439

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Val Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Val Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln 
                805                 810                 815     


Leu Tyr Val Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Met Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Ala Asp Asp 
                885                 890                 895     


Thr Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Thr Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp 
        915                 920                 925             


Cys Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala 
    930                 935                 940             


<210>  440
<211>  1951
<212>  PRT
<213>  Homo sapiens

<400>  440

Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu 
        275                 280                 285             


Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr 
    290                 295                 300                 


Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu 
                325                 330                 335     


Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys 
            340                 345                 350         


Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr 
        355                 360                 365             


Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr 
    370                 375                 380                 


Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr 
385                 390                 395                 400 


Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val 
                405                 410                 415     


Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln 
            420                 425                 430         


Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met 
        435                 440                 445             


Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala 
    450                 455                 460                 


Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu 
465                 470                 475                 480 


Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala 
                485                 490                 495     


Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu 
            500                 505                 510         


Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn 
    530                 535                 540                 


Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser 
                565                 570                 575     


Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn 
    610                 615                 620                 


Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser Tyr 
625                 630                 635                 640 


Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg Ala 
                645                 650                 655     


Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
            660                 665                 670         


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val Phe 
        675                 680                 685             


Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu Val 
    690                 695                 700                 


Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
705                 710                 715                 720 


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
                725                 730                 735     


Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly 
            740                 745                 750         


Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro Tyr 
        755                 760                 765             


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val Ser 
    770                 775                 780                 


Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser Val 
785                 790                 795                 800 


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
                805                 810                 815     


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
            820                 825                 830         


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
        835                 840                 845             


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
    850                 855                 860                 


Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe 
865                 870                 875                 880 


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
                885                 890                 895     


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
            900                 905                 910         


Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
        915                 920                 925             


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
    930                 935                 940                 


Ala Thr Asp Asp Asp Asn Glu Met Asn Asn Leu Gln Ile Ala Val Gly 
945                 950                 955                 960 


Arg Met Gln Lys Gly Ile Asp Tyr Val Lys Asn Lys Met Arg Glu Cys 
                965                 970                 975     


Phe Gln Lys Ala Phe Phe Arg Lys Pro Lys Val Ile Glu Ile His Glu 
            980                 985                 990         


Gly Asn Lys Ile Asp Ser Cys Met  Ser Asn Asn Thr Gly  Ile Glu Ile 
        995                 1000                 1005             


Ser Lys  Glu Leu Asn Tyr Leu  Arg Asp Gly Asn Gly  Thr Thr Ser 
    1010                 1015                 1020             


Gly Val  Gly Thr Gly Ser Ser  Val Glu Lys Tyr Val  Ile Asp Glu 
    1025                 1030                 1035             


Asn Asp  Tyr Met Ser Phe Ile  Asn Asn Pro Ser Leu  Thr Val Thr 
    1040                 1045                 1050             


Val Pro  Ile Ala Val Gly Glu  Ser Asp Phe Glu Asn  Leu Asn Thr 
    1055                 1060                 1065             


Glu Glu  Phe Ser Ser Glu Ser  Glu Leu Glu Glu Ser  Lys Glu Lys 
    1070                 1075                 1080             


Leu Asn  Ala Thr Ser Ser Ser  Glu Gly Ser Thr Val  Asp Val Val 
    1085                 1090                 1095             


Leu Pro  Arg Glu Gly Glu Gln  Ala Glu Thr Glu Pro  Glu Glu Asp 
    1100                 1105                 1110             


Leu Lys  Pro Glu Ala Cys Phe  Thr Glu Gly Cys Ile  Lys Lys Phe 
    1115                 1120                 1125             


Pro Phe  Cys Gln Val Ser Thr  Glu Glu Gly Lys Gly  Lys Ile Trp 
    1130                 1135                 1140             


Trp Asn  Leu Arg Lys Thr Cys  Tyr Ser Ile Val Glu  His Asn Trp 
    1145                 1150                 1155             


Phe Glu  Thr Phe Ile Val Phe  Met Ile Leu Leu Ser  Ser Gly Ala 
    1160                 1165                 1170             


Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Gln Arg Lys  Thr Ile Lys 
    1175                 1180                 1185             


Thr Met  Leu Glu Tyr Ala Asp  Lys Val Phe Thr Tyr  Ile Phe Ile 
    1190                 1195                 1200             


Leu Glu  Met Leu Leu Lys Trp  Val Ala Tyr Gly Phe  Gln Thr Tyr 
    1205                 1210                 1215             


Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe Leu Ile  Val Asp Val 
    1220                 1225                 1230             


Ser Leu  Val Ser Leu Val Ala  Asn Ala Leu Gly Tyr  Ser Glu Leu 
    1235                 1240                 1245             


Gly Ala  Ile Lys Ser Leu Arg  Thr Leu Arg Ala Leu  Arg Pro Leu 
    1250                 1255                 1260             


Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg Val Val  Val Asn Ala 
    1265                 1270                 1275             


Leu Val  Gly Ala Ile Pro Ser  Ile Met Asn Val Leu  Leu Val Cys 
    1280                 1285                 1290             


Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met Gly Val  Asn Leu Phe 
    1295                 1300                 1305             


Ala Gly  Lys Phe Tyr His Cys  Val Asn Met Thr Thr  Gly Asn Met 
    1310                 1315                 1320             


Phe Asp  Ile Ser Asp Val Asn  Asn Leu Ser Asp Cys  Gln Ala Leu 
    1325                 1330                 1335             


Gly Lys  Gln Ala Arg Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn 
    1340                 1345                 1350             


Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln Val Ala  Thr Phe Lys 
    1355                 1360                 1365             


Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val Asp Ser  Arg Asp Val 
    1370                 1375                 1380             


Lys Leu  Gln Pro Val Tyr Glu  Glu Asn Leu Tyr Met  Tyr Leu Tyr 
    1385                 1390                 1395             


Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu 
    1400                 1405                 1410             


Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys 
    1415                 1420                 1425             


Phe Gly  Gly Gln Asp Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr 
    1430                 1435                 1440             


Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro 
    1445                 1450                 1455             


Ile Pro  Arg Pro Ala Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe 
    1460                 1465                 1470             


Val Thr  Arg Gln Val Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys 
    1475                 1480                 1485             


Leu Asn  Met Val Thr Met Met  Val Glu Thr Asp Asp  Gln Gly Lys 
    1490                 1495                 1500             


Tyr Met  Thr Leu Val Leu Ser  Arg Ile Asn Leu Val  Phe Ile Val 
    1505                 1510                 1515             


Leu Phe  Thr Gly Glu Phe Val  Leu Lys Leu Val Ser  Leu Arg His 
    1520                 1525                 1530             


Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe Asp Phe  Val Val Val 
    1535                 1540                 1545             


Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala Glu Met  Ile Glu Lys 
    1550                 1555                 1560             


Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg 
    1565                 1570                 1575             


Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg 
    1580                 1585                 1590             


Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn 
    1595                 1600                 1605             


Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe 
    1610                 1615                 1620             


Gly Met  Ser Asn Phe Ala Tyr  Val Lys Lys Glu Ala  Gly Ile Asp 
    1625                 1630                 1635             


Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu 
    1640                 1645                 1650             


Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro 
    1655                 1660                 1665             


Ile Leu  Asn Ser Ala Pro Pro  Asp Cys Asp Pro Asp  Thr Ile His 
    1670                 1675                 1680             


Pro Gly  Ser Ser Val Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly 
    1685                 1690                 1695             


Ile Phe  Phe Phe Val Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val 
    1700                 1705                 1710             


Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala 
    1715                 1720                 1725             


Thr Glu  Glu Ser Ala Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met 
    1730                 1735                 1740             


Phe Tyr  Glu Val Trp Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe 
    1745                 1750                 1755             


Ile Glu  Phe Ser Lys Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro 
    1760                 1765                 1770             


Pro Leu  Leu Ile Ala Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met 
    1775                 1780                 1785             


Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile 
    1790                 1795                 1800             


Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met 
    1805                 1810                 1815             


Asp Ala  Leu Arg Ile Gln Met  Glu Asp Arg Phe Met  Ala Ser Asn 
    1820                 1825                 1830             


Pro Ser  Lys Val Ser Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg 
    1835                 1840                 1845             


Lys Gln  Glu Glu Val Ser Ala  Ala Ile Ile Gln Arg  Asn Phe Arg 
    1850                 1855                 1860             


Cys Tyr  Leu Leu Lys Gln Arg  Leu Lys Asn Ile Ser  Ser Asn Tyr 
    1865                 1870                 1875             


Asn Lys  Glu Ala Ile Lys Gly  Arg Ile Asp Leu Pro  Ile Lys Gln 
    1880                 1885                 1890             


Asp Met  Ile Ile Asp Lys Leu  Asn Gly Asn Ser Thr  Pro Glu Lys 
    1895                 1900                 1905             


Thr Asp  Gly Ser Ser Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser 
    1910                 1915                 1920             


Val Thr  Lys Pro Asp Lys Glu  Lys Phe Glu Lys Asp  Lys Pro Glu 
    1925                 1930                 1935             


Lys Glu  Ser Lys Gly Lys Glu  Val Arg Glu Asn Gln  Lys 
    1940                 1945                 1950     


<210>  441
<211>  1951
<212>  PRT
<213>  Homo sapiens

<400>  441

Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Ser 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu 
        275                 280                 285             


Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr 
    290                 295                 300                 


Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu 
                325                 330                 335     


Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys 
            340                 345                 350         


Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr 
        355                 360                 365             


Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr 
    370                 375                 380                 


Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr 
385                 390                 395                 400 


Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val 
                405                 410                 415     


Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln 
            420                 425                 430         


Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met 
        435                 440                 445             


Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala 
    450                 455                 460                 


Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu 
465                 470                 475                 480 


Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala 
                485                 490                 495     


Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu 
            500                 505                 510         


Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn 
    530                 535                 540                 


Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser 
                565                 570                 575     


Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn 
    610                 615                 620                 


Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser Tyr 
625                 630                 635                 640 


Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg Ala 
                645                 650                 655     


Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
            660                 665                 670         


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val Phe 
        675                 680                 685             


Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu Val 
    690                 695                 700                 


Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
705                 710                 715                 720 


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
                725                 730                 735     


Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly 
            740                 745                 750         


Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro Tyr 
        755                 760                 765             


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val Ser 
    770                 775                 780                 


Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser Val 
785                 790                 795                 800 


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
                805                 810                 815     


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
            820                 825                 830         


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
        835                 840                 845             


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
    850                 855                 860                 


Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe 
865                 870                 875                 880 


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
                885                 890                 895     


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
            900                 905                 910         


Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
        915                 920                 925             


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
    930                 935                 940                 


Ala Thr Asp Asp Asp Asn Glu Met Asn Asn Leu Gln Ile Ala Val Gly 
945                 950                 955                 960 


Arg Met Gln Lys Gly Ile Asp Tyr Val Lys Asn Lys Met Arg Glu Cys 
                965                 970                 975     


Phe Gln Lys Ala Phe Phe Arg Lys Pro Lys Val Ile Glu Ile His Glu 
            980                 985                 990         


Gly Asn Lys Ile Asp Ser Cys Met  Ser Asn Asn Thr Gly  Ile Glu Ile 
        995                 1000                 1005             


Ser Lys  Glu Leu Asn Tyr Leu  Arg Asp Gly Asn Gly  Thr Thr Ser 
    1010                 1015                 1020             


Gly Val  Gly Thr Gly Ser Ser  Val Glu Lys Tyr Val  Ile Asp Glu 
    1025                 1030                 1035             


Asn Asp  Tyr Met Ser Phe Ile  Asn Asn Pro Ser Leu  Thr Val Thr 
    1040                 1045                 1050             


Val Pro  Ile Ala Val Gly Glu  Ser Asp Phe Glu Asn  Leu Asn Thr 
    1055                 1060                 1065             


Glu Glu  Phe Ser Ser Glu Ser  Glu Leu Glu Glu Ser  Lys Glu Lys 
    1070                 1075                 1080             


Leu Asn  Ala Thr Ser Ser Ser  Glu Gly Ser Thr Val  Asp Val Val 
    1085                 1090                 1095             


Leu Pro  Arg Glu Gly Glu Gln  Ala Glu Thr Glu Pro  Glu Glu Asp 
    1100                 1105                 1110             


Leu Lys  Pro Glu Ala Cys Phe  Thr Glu Gly Cys Ile  Lys Lys Phe 
    1115                 1120                 1125             


Pro Phe  Cys Gln Val Ser Thr  Glu Glu Gly Lys Gly  Lys Ile Trp 
    1130                 1135                 1140             


Trp Asn  Leu Arg Lys Thr Cys  Tyr Ser Ile Val Glu  His Asn Trp 
    1145                 1150                 1155             


Phe Glu  Thr Phe Ile Val Phe  Met Ile Leu Leu Ser  Ser Gly Ala 
    1160                 1165                 1170             


Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Gln Arg Lys  Thr Ile Lys 
    1175                 1180                 1185             


Thr Met  Leu Glu Tyr Ala Asp  Lys Val Phe Thr Tyr  Ile Phe Ile 
    1190                 1195                 1200             


Leu Glu  Met Leu Leu Lys Trp  Val Ala Tyr Gly Phe  Gln Thr Tyr 
    1205                 1210                 1215             


Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe Leu Ile  Val Asp Val 
    1220                 1225                 1230             


Ser Leu  Val Ser Leu Val Ala  Asn Ala Leu Gly Tyr  Ser Glu Leu 
    1235                 1240                 1245             


Gly Ala  Ile Lys Ser Leu Arg  Thr Leu Arg Ala Leu  Arg Pro Leu 
    1250                 1255                 1260             


Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg Val Val  Val Asn Ala 
    1265                 1270                 1275             


Leu Val  Gly Ala Ile Pro Ser  Ile Met Asn Val Leu  Leu Val Cys 
    1280                 1285                 1290             


Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met Gly Val  Asn Leu Phe 
    1295                 1300                 1305             


Ala Gly  Lys Phe Tyr His Cys  Val Asn Met Thr Thr  Gly Asn Met 
    1310                 1315                 1320             


Phe Asp  Ile Ser Asp Val Asn  Asn Leu Ser Asp Cys  Gln Ala Leu 
    1325                 1330                 1335             


Gly Lys  Gln Ala Arg Trp Lys  Asn Val Lys Val Asn  Phe Asp Asn 
    1340                 1345                 1350             


Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln Val Ala  Thr Phe Lys 
    1355                 1360                 1365             


Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val Asp Ser  Arg Asp Val 
    1370                 1375                 1380             


Lys Leu  Gln Pro Val Tyr Glu  Glu Asn Leu Tyr Met  Tyr Leu Tyr 
    1385                 1390                 1395             


Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu 
    1400                 1405                 1410             


Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys 
    1415                 1420                 1425             


Phe Gly  Gly Gln Asp Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr 
    1430                 1435                 1440             


Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro 
    1445                 1450                 1455             


Ile Pro  Arg Pro Ala Asn Lys  Phe Gln Gly Met Val  Phe Asp Phe 
    1460                 1465                 1470             


Val Thr  Arg Gln Val Phe Asp  Ile Ser Ile Met Ile  Leu Ile Cys 
    1475                 1480                 1485             


Leu Asn  Met Val Thr Met Met  Val Glu Thr Asp Asp  Gln Gly Lys 
    1490                 1495                 1500             


Tyr Met  Thr Leu Val Leu Ser  Arg Ile Asn Leu Val  Phe Ile Val 
    1505                 1510                 1515             


Leu Phe  Thr Gly Glu Phe Val  Leu Lys Leu Val Ser  Leu Arg His 
    1520                 1525                 1530             


Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe Asp Phe  Val Val Val 
    1535                 1540                 1545             


Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala Glu Met  Ile Glu Lys 
    1550                 1555                 1560             


Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg 
    1565                 1570                 1575             


Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg 
    1580                 1585                 1590             


Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn 
    1595                 1600                 1605             


Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe Ile Tyr  Ala Ile Phe 
    1610                 1615                 1620             


Gly Met  Ser Asn Phe Ala Tyr  Val Lys Lys Glu Ala  Gly Ile Asp 
    1625                 1630                 1635             


Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu 
    1640                 1645                 1650             


Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp Gly Leu  Leu Ala Pro 
    1655                 1660                 1665             


Ile Leu  Asn Ser Ala Pro Pro  Asp Cys Asp Pro Asp  Thr Ile His 
    1670                 1675                 1680             


Pro Gly  Ser Ser Val Lys Gly  Asp Cys Gly Asn Pro  Ser Val Gly 
    1685                 1690                 1695             


Ile Phe  Phe Phe Val Ser Tyr  Ile Ile Ile Ser Phe  Leu Val Val 
    1700                 1705                 1710             


Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu Asn Phe  Ser Val Ala 
    1715                 1720                 1725             


Thr Glu  Glu Ser Ala Glu Pro  Leu Ser Glu Asp Asp  Phe Glu Met 
    1730                 1735                 1740             


Phe Tyr  Glu Val Trp Glu Lys  Phe Asp Pro Asp Ala  Thr Gln Phe 
    1745                 1750                 1755             


Ile Glu  Phe Ser Lys Leu Ser  Asp Phe Ala Ala Ala  Leu Asp Pro 
    1760                 1765                 1770             


Pro Leu  Leu Ile Ala Lys Pro  Asn Lys Val Gln Leu  Ile Ala Met 
    1775                 1780                 1785             


Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile His Cys  Leu Asp Ile 
    1790                 1795                 1800             


Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly Glu Ser  Gly Glu Met 
    1805                 1810                 1815             


Asp Ala  Leu Arg Ile Gln Met  Glu Asp Arg Phe Met  Ala Ser Asn 
    1820                 1825                 1830             


Pro Ser  Lys Val Ser Tyr Glu  Pro Ile Thr Thr Thr  Leu Lys Arg 
    1835                 1840                 1845             


Lys Gln  Glu Glu Val Ser Ala  Ala Ile Ile Gln Arg  Asn Phe Arg 
    1850                 1855                 1860             


Cys Tyr  Leu Leu Lys Gln Arg  Leu Lys Asn Ile Ser  Ser Asn Tyr 
    1865                 1870                 1875             


Asn Lys  Glu Ala Ile Lys Gly  Arg Ile Asp Leu Pro  Ile Lys Gln 
    1880                 1885                 1890             


Asp Met  Ile Ile Asp Lys Leu  Asn Gly Asn Ser Thr  Pro Glu Lys 
    1895                 1900                 1905             


Thr Asp  Gly Ser Ser Ser Thr  Thr Ser Pro Pro Ser  Tyr Asp Ser 
    1910                 1915                 1920             


Val Thr  Lys Pro Asp Lys Glu  Lys Phe Glu Lys Asp  Lys Pro Glu 
    1925                 1930                 1935             


Lys Glu  Ser Lys Gly Lys Glu  Val Arg Glu Asn Gln  Lys 
    1940                 1945                 1950     


<210>  442
<211>  2000
<212>  PRT
<213>  Homo sapiens

<400>  442

Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu 
        275                 280                 285             


Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr 
    290                 295                 300                 


Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu 
                325                 330                 335     


Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys 
            340                 345                 350         


Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr 
        355                 360                 365             


Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr 
    370                 375                 380                 


Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr 
385                 390                 395                 400 


Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val 
                405                 410                 415     


Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln 
            420                 425                 430         


Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met 
        435                 440                 445             


Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala 
    450                 455                 460                 


Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu 
465                 470                 475                 480 


Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala 
                485                 490                 495     


Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu 
            500                 505                 510         


Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn 
    530                 535                 540                 


Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser 
                565                 570                 575     


Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Met Ser Ser Arg Met Val Pro Gly Leu Pro Ala 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Thr Gly Gln Leu Pro Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser 
        675                 680                 685             


Tyr Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg 
    690                 695                 700                 


Ala Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val 
                725                 730                 735     


Phe Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu 
            740                 745                 750         


Val Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Tyr Val Lys Asn  Lys Met Arg 
    1010                 1015                 1020             


Glu Cys  Phe Gln Lys Ala Phe  Phe Arg Lys Pro Lys  Val Ile Glu 
    1025                 1030                 1035             


Ile His  Glu Gly Asn Lys Ile  Asp Ser Cys Met Ser  Asn Asn Thr 
    1040                 1045                 1050             


Gly Ile  Glu Ile Ser Lys Glu  Leu Asn Tyr Leu Arg  Asp Gly Asn 
    1055                 1060                 1065             


Gly Thr  Thr Ser Gly Val Gly  Thr Gly Ser Ser Val  Glu Lys Tyr 
    1070                 1075                 1080             


Val Ile  Asp Glu Asn Asp Tyr  Met Ser Phe Ile Asn  Asn Pro Ser 
    1085                 1090                 1095             


Leu Thr  Val Thr Val Pro Ile  Ala Val Gly Glu Ser  Asp Phe Glu 
    1100                 1105                 1110             


Asn Leu  Asn Thr Glu Glu Phe  Ser Ser Glu Ser Glu  Leu Glu Glu 
    1115                 1120                 1125             


Ser Lys  Glu Lys Leu Asn Ala  Thr Ser Ser Ser Glu  Gly Ser Thr 
    1130                 1135                 1140             


Val Asp  Val Val Leu Pro Arg  Glu Gly Glu Gln Ala  Glu Thr Glu 
    1145                 1150                 1155             


Pro Glu  Glu Asp Leu Lys Pro  Glu Ala Cys Phe Thr  Glu Gly Cys 
    1160                 1165                 1170             


Ile Lys  Lys Phe Pro Phe Cys  Gln Val Ser Thr Glu  Glu Gly Lys 
    1175                 1180                 1185             


Gly Lys  Ile Trp Trp Asn Leu  Arg Lys Thr Cys Tyr  Ser Ile Val 
    1190                 1195                 1200             


Glu His  Asn Trp Phe Glu Thr  Phe Ile Val Phe Met  Ile Leu Leu 
    1205                 1210                 1215             


Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile Tyr Ile  Glu Gln Arg 
    1220                 1225                 1230             


Lys Thr  Ile Lys Thr Met Leu  Glu Tyr Ala Asp Lys  Val Phe Thr 
    1235                 1240                 1245             


Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys Trp Val  Ala Tyr Gly 
    1250                 1255                 1260             


Phe Gln  Thr Tyr Phe Thr Asn  Ala Trp Cys Trp Leu  Asp Phe Leu 
    1265                 1270                 1275             


Ile Val  Asp Val Ser Leu Val  Ser Leu Val Ala Asn  Ala Leu Gly 
    1280                 1285                 1290             


Tyr Ser  Glu Leu Gly Ala Ile  Lys Ser Leu Arg Thr  Leu Arg Ala 
    1295                 1300                 1305             


Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe Glu Gly  Met Arg Val 
    1310                 1315                 1320             


Val Val  Asn Ala Leu Val Gly  Ala Ile Pro Ser Ile  Met Asn Val 
    1325                 1330                 1335             


Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile Phe Ser  Ile Met Gly 
    1340                 1345                 1350             


Val Asn  Leu Phe Ala Gly Lys  Phe Tyr His Cys Val  Asn Met Thr 
    1355                 1360                 1365             


Thr Gly  Asn Met Phe Asp Ile  Ser Asp Val Asn Asn  Leu Ser Asp 
    1370                 1375                 1380             


Cys Gln  Ala Leu Gly Lys Gln  Ala Arg Trp Lys Asn  Val Lys Val 
    1385                 1390                 1395             


Asn Phe  Asp Asn Val Gly Ala  Gly Tyr Leu Ala Leu  Leu Gln Val 
    1400                 1405                 1410             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1415                 1420                 1425             


Ser Arg  Asp Val Lys Leu Gln  Pro Val Tyr Glu Glu  Asn Leu Tyr 
    1430                 1435                 1440             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1445                 1450                 1455             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1460                 1465                 1470             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1475                 1480                 1485             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1490                 1495                 1500             


Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn Lys Phe  Gln Gly Met 
    1505                 1510                 1515             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1520                 1525                 1530             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1535                 1540                 1545             


Asp Gln  Gly Lys Tyr Met Thr  Leu Val Leu Ser Arg  Ile Asn Leu 
    1550                 1555                 1560             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Phe Val Leu  Lys Leu Val 
    1565                 1570                 1575             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1580                 1585                 1590             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1595                 1600                 1605             


Met Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1610                 1615                 1620             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1625                 1630                 1635             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1640                 1645                 1650             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1655                 1660                 1665             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Lys Glu 
    1670                 1675                 1680             


Ala Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1685                 1690                 1695             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1700                 1705                 1710             


Leu Leu  Ala Pro Ile Leu Asn  Ser Ala Pro Pro Asp  Cys Asp Pro 
    1715                 1720                 1725             


Asp Thr  Ile His Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1730                 1735                 1740             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1745                 1750                 1755             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1760                 1765                 1770             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1775                 1780                 1785             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1790                 1795                 1800             


Ala Thr  Gln Phe Ile Glu Phe  Ser Lys Leu Ser Asp  Phe Ala Ala 
    1805                 1810                 1815             


Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys Pro Asn  Lys Val Gln 
    1820                 1825                 1830             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1835                 1840                 1845             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1850                 1855                 1860             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Asp Arg Phe 
    1865                 1870                 1875             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr 
    1880                 1885                 1890             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Ala  Ile Ile Gln 
    1895                 1900                 1905             


Arg Asn  Phe Arg Cys Tyr Leu  Leu Lys Gln Arg Leu  Lys Asn Ile 
    1910                 1915                 1920             


Ser Ser  Asn Tyr Asn Lys Glu  Ala Ile Lys Gly Arg  Ile Asp Leu 
    1925                 1930                 1935             


Pro Ile  Lys Gln Asp Met Ile  Ile Asp Lys Leu Asn  Gly Asn Ser 
    1940                 1945                 1950             


Thr Pro  Glu Lys Thr Asp Gly  Ser Ser Ser Thr Thr  Ser Pro Pro 
    1955                 1960                 1965             


Ser Tyr  Asp Ser Val Thr Lys  Pro Asp Lys Glu Lys  Phe Glu Lys 
    1970                 1975                 1980             


Asp Lys  Pro Glu Lys Glu Ser  Lys Gly Lys Glu Val  Arg Glu Asn 
    1985                 1990                 1995             


Gln Lys  
    2000 


<210>  443
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  443

Met Pro Ala Phe Asn Arg Leu Phe Pro Leu Ala Ser Leu Val Leu Ile 
1               5                   10                  15      


Tyr Trp Val Ser Val Cys Phe Pro Val Cys Val Glu Val Pro Ser Glu 
            20                  25                  30          


Thr Glu Ala Val Gln Gly Asn Pro Met Lys Leu Arg Cys Ile Ser Cys 
        35                  40                  45              


Met Lys Arg Glu Glu Val Glu Ala Thr Thr Val Val Glu Trp Phe Tyr 
    50                  55                  60                  


Arg Pro Glu Gly Gly Lys Asp Phe Leu Ile Tyr Glu Tyr Arg Asn Gly 
65                  70                  75                  80  


His Gln Glu Val Glu Ser Pro Phe Gln Gly Arg Leu Gln Trp Asn Gly 
                85                  90                  95      


Ser Lys Asp Leu Gln Asp Val Ser Ile Thr Val Leu Asn Val Thr Leu 
            100                 105                 110         


Asn Asp Ser Gly Leu Tyr Thr Cys Asn Val Ser Arg Glu Phe Glu Phe 
        115                 120                 125             


Glu Ala His Arg Pro Phe Val Lys Thr Thr Arg Leu Ile Pro Leu Arg 
    130                 135                 140                 


Val Thr Glu Glu Ala Gly Glu Asp Phe Thr Ser Val Val Ser Glu Ile 
145                 150                 155                 160 


Met Met Tyr Ile Leu Leu Val Phe Leu Thr Leu Trp Leu Leu Ile Glu 
                165                 170                 175     


Met Ile Tyr Cys Tyr Arg Lys Val Ser Lys Ala Glu Glu Ala Ala Gln 
            180                 185                 190         


Glu Asn Ala Ser Asp Tyr Leu Ala Ile Pro Ser Glu Asn Lys Glu Asn 
        195                 200                 205             


Ser Ala Val Pro Val Glu Glu 
    210                 215 


<210>  444
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  444

Met Pro Ala Phe Asn Arg Leu Phe Pro Leu Ala Ser Leu Val Leu Ile 
1               5                   10                  15      


Tyr Trp Val Ser Val Cys Phe Pro Val Cys Val Glu Val Pro Ser Glu 
            20                  25                  30          


Thr Glu Ala Val Gln Gly Asn Pro Met Lys Leu Arg Cys Ile Ser Cys 
        35                  40                  45              


Met Lys Arg Glu Glu Val Glu Ala Thr Thr Val Val Glu Trp Phe Tyr 
    50                  55                  60                  


Arg Pro Glu Gly Gly Lys Asp Phe Leu Ile Tyr Glu Tyr Arg Asn Gly 
65                  70                  75                  80  


His Gln Glu Val Glu Ser Pro Phe Gln Gly Arg Leu Gln Trp Asn Gly 
                85                  90                  95      


Ser Lys Asp Leu Gln Asp Val Ser Ile Thr Val Leu Asn Val Thr Leu 
            100                 105                 110         


Asn Asp Ser Gly Leu Tyr Thr Cys Asn Val Ser Arg Glu Phe Glu Phe 
        115                 120                 125             


Glu Ala His Arg Pro Phe Val Lys Thr Thr Arg Leu Ile Pro Leu Arg 
    130                 135                 140                 


Val Thr Glu Glu Ala Gly Glu Asp Phe Thr Ser Val Val Ser Glu Ile 
145                 150                 155                 160 


Met Met Tyr Ile Leu Leu Val Phe Leu Thr Leu Trp Leu Leu Ile Glu 
                165                 170                 175     


Met Ile Tyr Cys Tyr Arg Lys Val Ser Lys Ala Glu Glu Ala Ala Gln 
            180                 185                 190         


Glu Asn Ala Ser Asp Tyr Leu Ala Ile Pro Ser Glu Asn Lys Glu Asn 
        195                 200                 205             


Ser Ala Val Pro Val Glu Glu 
    210                 215 


<210>  445
<211>  1836
<212>  PRT
<213>  Homo sapiens

<400>  445

Met Ala Arg Pro Ser Leu Cys Thr Leu Val Pro Leu Gly Pro Glu Cys 
1               5                   10                  15      


Leu Arg Pro Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ala 
            20                  25                  30          


Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys Gln Met Glu Ile Glu 
        35                  40                  45              


Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu Ala Gly Lys Asn Leu 
    50                  55                  60                  


Pro Met Ile Tyr Gly Asp Pro Pro Pro Glu Val Ile Gly Ile Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Pro Ala Leu Tyr 
            100                 105                 110         


Leu Leu Ser Pro Phe Ser Val Val Arg Arg Gly Ala Ile Lys Val Leu 
        115                 120                 125             


Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro Trp Ser Lys Asn Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Leu Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp Pro Pro Pro Phe Asn 
        275                 280                 285             


Asp Thr Asn Thr Thr Trp Tyr Ser Asn Asp Thr Trp Tyr Gly Asn Asp 
    290                 295                 300                 


Thr Trp Tyr Gly Asn Glu Met Trp Tyr Gly Asn Asp Ser Trp Tyr Ala 
305                 310                 315                 320 


Asn Asp Thr Trp Asn Ser His Ala Ser Trp Ala Thr Asn Asp Thr Phe 
                325                 330                 335     


Asp Trp Asp Ala Tyr Ile Ser Asp Glu Gly Asn Phe Tyr Phe Leu Glu 
            340                 345                 350         


Gly Ser Asn Asp Ala Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly His 
        355                 360                 365             


Cys Pro Glu Gly Tyr Glu Cys Ile Lys Thr Gly Arg Asn Pro Asn Tyr 
    370                 375                 380                 


Gly Tyr Thr Ser Tyr Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe 
385                 390                 395                 400 


Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Phe Gln Leu Thr Leu 
                405                 410                 415     


Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Ile Ile Phe 
            420                 425                 430         


Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala Met 
        435                 440                 445             


Ala Tyr Ala Glu Gln Asn Glu Ala Thr Leu Ala Glu Asp Lys Glu Lys 
    450                 455                 460                 


Glu Glu Glu Phe Gln Gln Met Leu Glu Lys Phe Lys Lys His Gln Glu 
465                 470                 475                 480 


Glu Leu Glu Lys Ala Lys Ala Ala Gln Ala Leu Glu Gly Gly Glu Ala 
                485                 490                 495     


Asp Gly Asp Pro Ala His Gly Lys Asp Cys Asn Gly Ser Leu Asp Thr 
            500                 505                 510         


Ser Gln Gly Glu Lys Gly Ala Pro Arg Gln Ser Ser Ser Gly Asp Ser 
        515                 520                 525             


Gly Ile Ser Asp Ala Met Glu Glu Leu Glu Glu Ala His Gln Lys Cys 
    530                 535                 540                 


Pro Pro Trp Trp Tyr Lys Cys Ala His Lys Val Leu Ile Trp Asn Cys 
545                 550                 555                 560 


Cys Ala Pro Trp Leu Lys Phe Lys Asn Ile Ile His Leu Ile Val Met 
                565                 570                 575     


Asp Pro Phe Val Asp Leu Gly Ile Thr Ile Cys Ile Val Leu Asn Thr 
            580                 585                 590         


Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asp Asn 
        595                 600                 605             


Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
    610                 615                 620                 


Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Gln 
625                 630                 635                 640 


Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Thr Leu Ser Leu Val Glu 
                645                 650                 655     


Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val Leu Arg Ser Phe Arg 
            660                 665                 670         


Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met 
        675                 680                 685             


Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
    690                 695                 700                 


Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
705                 710                 715                 720 


Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Ala Leu Asp 
                725                 730                 735     


Cys Asn Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu 
            740                 745                 750         


Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp 
        755                 760                 765             


Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Leu Met 
    770                 775                 780                 


Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu 
785                 790                 795                 800 


Leu Leu Ser Ser Phe Ser Ala Asp Ser Leu Ala Ala Ser Asp Glu Asp 
                805                 810                 815     


Gly Glu Met Asn Asn Leu Gln Ile Ala Ile Gly Arg Ile Lys Leu Gly 
            820                 825                 830         


Ile Gly Phe Ala Lys Ala Phe Leu Leu Gly Leu Leu His Gly Lys Ile 
        835                 840                 845             


Leu Ser Pro Lys Asp Ile Met Leu Ser Leu Gly Glu Ala Asp Gly Ala 
    850                 855                 860                 


Gly Glu Ala Gly Glu Ala Gly Glu Thr Ala Pro Glu Asp Glu Lys Lys 
865                 870                 875                 880 


Glu Pro Pro Glu Glu Asp Leu Lys Lys Asp Asn His Ile Leu Asn His 
                885                 890                 895     


Met Gly Leu Ala Asp Gly Pro Pro Ser Ser Leu Glu Leu Asp His Leu 
            900                 905                 910         


Asn Phe Ile Asn Asn Pro Tyr Leu Thr Ile Gln Val Pro Ile Ala Ser 
        915                 920                 925             


Glu Glu Ser Asp Leu Glu Met Pro Thr Glu Glu Glu Thr Asp Thr Phe 
    930                 935                 940                 


Ser Glu Pro Glu Asp Ser Lys Lys Pro Pro Gln Pro Leu Tyr Asp Gly 
945                 950                 955                 960 


Asn Ser Ser Val Cys Ser Thr Ala Asp Tyr Lys Pro Pro Glu Glu Asp 
                965                 970                 975     


Pro Glu Glu Gln Ala Glu Glu Asn Pro Glu Gly Glu Gln Pro Glu Glu 
            980                 985                 990         


Cys Phe Thr Glu Ala Cys Val Gln  Arg Trp Pro Cys Leu  Tyr Val Asp 
        995                 1000                 1005             


Ile Ser  Gln Gly Arg Gly Lys  Lys Trp Trp Thr Leu  Arg Arg Ala 
    1010                 1015                 1020             


Cys Phe  Lys Ile Val Glu His  Asn Trp Phe Glu Thr  Phe Ile Val 
    1025                 1030                 1035             


Phe Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1040                 1045                 1050             


Tyr Ile  Glu Gln Arg Arg Val  Ile Arg Thr Ile Leu  Glu Tyr Ala 
    1055                 1060                 1065             


Asp Lys  Val Phe Thr Tyr Ile  Phe Ile Met Glu Met  Leu Leu Lys 
    1070                 1075                 1080             


Trp Val  Ala Tyr Gly Phe Lys  Val Tyr Phe Thr Asn  Ala Trp Cys 
    1085                 1090                 1095             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Ile Ile  Ser Leu Val 
    1100                 1105                 1110             


Ala Asn  Trp Leu Gly Tyr Ser  Glu Leu Gly Pro Ile  Lys Ser Leu 
    1115                 1120                 1125             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1130                 1135                 1140             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Leu Gly  Ala Ile Pro 
    1145                 1150                 1155             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1160                 1165                 1170             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Tyr 
    1175                 1180                 1185             


Cys Ile  Asn Thr Thr Thr Ser  Glu Arg Phe Asp Ile  Ser Glu Val 
    1190                 1195                 1200             


Asn Asn  Lys Ser Glu Cys Glu  Ser Leu Met His Thr  Gly Gln Val 
    1205                 1210                 1215             


Arg Trp  Leu Asn Val Lys Val  Asn Tyr Asp Asn Val  Gly Leu Gly 
    1220                 1225                 1230             


Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp 
    1235                 1240                 1245             


Ile Met  Tyr Ala Ala Val Asp  Ser Arg Glu Lys Glu  Glu Gln Pro 
    1250                 1255                 1260             


Gln Tyr  Glu Val Asn Leu Tyr  Met Tyr Leu Tyr Phe  Val Ile Phe 
    1265                 1270                 1275             


Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val 
    1280                 1285                 1290             


Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Lys 
    1295                 1300                 1305             


Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met 
    1310                 1315                 1320             


Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro 
    1325                 1330                 1335             


Gln Asn  Lys Ile Gln Gly Met  Val Tyr Asp Leu Val  Thr Lys Gln 
    1340                 1345                 1350             


Ala Phe  Asp Ile Thr Ile Met  Ile Leu Ile Cys Leu  Asn Met Val 
    1355                 1360                 1365             


Thr Met  Met Val Glu Thr Asp  Asn Gln Ser Gln Leu  Lys Val Asp 
    1370                 1375                 1380             


Ile Leu  Tyr Asn Ile Asn Met  Ile Phe Ile Ile Ile  Phe Thr Gly 
    1385                 1390                 1395             


Glu Cys  Val Leu Lys Met Leu  Ala Leu Arg Gln Tyr  Tyr Phe Thr 
    1400                 1405                 1410             


Val Gly  Trp Asn Ile Phe Asp  Phe Val Val Val Ile  Leu Ser Ile 
    1415                 1420                 1425             


Val Gly  Leu Ala Leu Ser Asp  Leu Ile Gln Lys Tyr  Phe Val Ser 
    1430                 1435                 1440             


Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala Arg Ile  Gly Arg Val 
    1445                 1450                 1455             


Leu Arg  Leu Ile Arg Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe 
    1460                 1465                 1470             


Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu 
    1475                 1480                 1485             


Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile Phe Gly  Met Ser Asn 
    1490                 1495                 1500             


Phe Ala  Tyr Val Lys Lys Glu  Ser Gly Ile Asp Asp  Met Phe Asn 
    1505                 1510                 1515             


Phe Glu  Thr Phe Gly Asn Ser  Ile Ile Cys Leu Phe  Glu Ile Thr 
    1520                 1525                 1530             


Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Asn Pro Ile  Leu Asn Ser 
    1535                 1540                 1545             


Gly Pro  Pro Asp Cys Asp Pro  Asn Leu Glu Asn Pro  Gly Thr Ser 
    1550                 1555                 1560             


Val Lys  Gly Asp Cys Gly Asn  Pro Ser Ile Gly Ile  Cys Phe Phe 
    1565                 1570                 1575             


Cys Ser  Tyr Ile Ile Ile Ser  Phe Leu Ile Val Val  Asn Met Tyr 
    1580                 1585                 1590             


Ile Ala  Ile Ile Leu Glu Asn  Phe Asn Val Ala Thr  Glu Glu Ser 
    1595                 1600                 1605             


Ser Glu  Pro Leu Gly Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Thr 
    1610                 1615                 1620             


Trp Glu  Lys Phe Asp Pro Asp  Ala Thr Gln Phe Ile  Ala Tyr Ser 
    1625                 1630                 1635             


Arg Leu  Ser Asp Phe Val Asp  Thr Leu Gln Glu Pro  Leu Arg Ile 
    1640                 1645                 1650             


Ala Lys  Pro Asn Lys Ile Lys  Leu Ile Thr Leu Asp  Leu Pro Met 
    1655                 1660                 1665             


Val Pro  Gly Asp Lys Ile His  Cys Leu Asp Ile Leu  Phe Ala Leu 
    1670                 1675                 1680             


Thr Lys  Glu Val Leu Gly Asp  Ser Gly Glu Met Asp  Ala Leu Lys 
    1685                 1690                 1695             


Gln Thr  Met Glu Glu Lys Phe  Met Ala Ala Asn Pro  Ser Lys Val 
    1700                 1705                 1710             


Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Lys Arg Lys  His Glu Glu 
    1715                 1720                 1725             


Val Cys  Ala Ile Lys Ile Gln  Arg Ala Tyr Arg Arg  His Leu Leu 
    1730                 1735                 1740             


Gln Arg  Ser Met Lys Gln Ala  Ser Tyr Met Tyr Arg  His Ser His 
    1745                 1750                 1755             


Asp Gly  Ser Gly Asp Asp Ala  Pro Glu Lys Glu Gly  Leu Leu Ala 
    1760                 1765                 1770             


Asn Thr  Met Ser Lys Met Tyr  Gly His Glu Asn Gly  Asn Ser Ser 
    1775                 1780                 1785             


Ser Pro  Ser Pro Glu Glu Lys  Gly Glu Ala Gly Asp  Ala Gly Pro 
    1790                 1795                 1800             


Thr Met  Gly Leu Met Pro Ile  Ser Pro Ser Asp Thr  Ala Trp Pro 
    1805                 1810                 1815             


Pro Ala  Pro Pro Pro Gly Gln  Thr Val Arg Pro Gly  Val Lys Glu 
    1820                 1825                 1830             


Ser Leu  Val 
    1835     


<210>  446
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  446

Met Pro Gly Ala Gly Asp Gly Gly Lys Ala Pro Ala Arg Trp Leu Gly 
1               5                   10                  15      


Thr Gly Leu Leu Val Glu Glu Val Asp Asn Thr Val Thr Leu Ile Ile 
            20                  25                  30          


Leu Ala Val Val Gly Gly Val Ile Gly Leu Leu Ile Leu Ile Leu Leu 
        35                  40                  45              


Ile Lys Lys Leu Ile Ile Phe Ile Leu Lys Lys Thr Arg Glu Lys Lys 
    50                  55                  60                  


Lys Glu Cys Leu Val Ser Ser Ser Gly Asn Asp Asn Thr Glu Asn Gly 
65                  70                  75                  80  


Leu Pro Gly Ser Lys Ala Glu Glu Lys Pro Pro Ser Lys Val 
                85                  90                  


<210>  447
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  447

Met Asn Asn Ile Ser Ile Val Leu Arg Asp Leu Glu Phe Ser Asp Thr 
1               5                   10                  15      


Gly Lys Tyr Thr Cys His Val Lys Asn Pro Lys Glu Asn Asn Leu Gln 
            20                  25                  30          


His His Ala Thr Ile Phe Leu Gln Val Val Asp Arg Leu Glu Glu Val 
        35                  40                  45              


Asp Asn Thr Val Thr Leu Ile Ile Leu Ala Val Val Gly Gly Val Ile 
    50                  55                  60                  


Gly Leu Leu Ile Leu Ile Leu Leu Ile Lys Lys Leu Ile Ile Phe Ile 
65                  70                  75                  80  


Leu Lys Lys Thr Arg Glu Lys Lys Lys Glu Cys Leu Val Ser Ser Ser 
                85                  90                  95      


Gly Asn Asp Asn Thr Glu Asn Gly Leu Pro Gly Ser Lys Ala Glu Glu 
            100                 105                 110         


Lys Pro Pro Ser Lys Val 
        115             


<210>  448
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  448

Met Pro Gly Ala Gly Asp Gly Gly Lys Ala Pro Ala Arg Trp Leu Gly 
1               5                   10                  15      


Thr Gly Leu Leu Gly Leu Phe Leu Leu Pro Val Thr Leu Ser Leu Glu 
            20                  25                  30          


Val Ser Val Gly Lys Ala Thr Asp Ile Tyr Ala Val Asn Gly Thr Glu 
        35                  40                  45              


Ile Leu Leu Pro Cys Thr Phe Ser Ser Cys Phe Gly Phe Glu Asp Leu 
    50                  55                  60                  


His Phe Arg Trp Thr Tyr Asn Ser Ser Asp Ala Phe Lys Ile Leu Ile 
65                  70                  75                  80  


Glu Gly Thr Val Lys Asn Glu Lys Ser Asp Pro Lys Val Thr Leu Lys 
                85                  90                  95      


Asp Asp Asp Arg Ile Thr Leu Val Gly Ser Thr Lys Glu Lys Met Asn 
            100                 105                 110         


Asn Ile Ser Ile Val Leu Arg Asp Leu Glu Phe Ser Asp Thr Gly Lys 
        115                 120                 125             


Tyr Thr Cys His Val Lys Asn Pro Lys Glu Asn Asn Leu Gln His His 
    130                 135                 140                 


Ala Thr Ile Phe Leu Gln Val Val Asp Arg Leu Glu Glu Val Asp Asn 
145                 150                 155                 160 


Thr Val Thr Leu Ile Ile Leu Ala Val Val Gly Gly Val Ile Gly Leu 
                165                 170                 175     


Leu Ile Leu Ile Leu Leu Ile Lys Lys Leu Ile Ile Phe Ile Leu Lys 
            180                 185                 190         


Lys Thr Arg Glu Lys Lys Lys Glu Cys Leu Val Ser Ser Ser Gly Asn 
        195                 200                 205             


Asp Asn Thr Glu Asn Gly Leu Pro Gly Ser Lys Ala Glu Glu Lys Pro 
    210                 215                 220                 


Pro Ser Lys Val 
225             


<210>  449
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  449

Met Glu Gly Asn Lys Leu Glu Glu Gln Asp Ser Ser Pro Pro Gln Ser 
1               5                   10                  15      


Thr Pro Gly Leu Met Lys Gly Asn Lys Arg Glu Glu Gln Gly Leu Gly 
            20                  25                  30          


Pro Glu Pro Ala Ala Pro Gln Gln Pro Thr Ala Glu Glu Glu Ala Leu 
        35                  40                  45              


Ile Glu Phe His Arg Ser Tyr Arg Glu Leu Phe Glu Phe Phe Cys Asn 
    50                  55                  60                  


Asn Thr Thr Ile His Gly Ala Ile Arg Leu Val Cys Ser Gln His Asn 
65                  70                  75                  80  


Arg Met Lys Thr Ala Phe Trp Ala Val Leu Trp Leu Cys Thr Phe Gly 
                85                  90                  95      


Met Met Tyr Trp Gln Phe Gly Leu Leu Phe Gly Glu Tyr Phe Ser Tyr 
            100                 105                 110         


Pro Val Ser Leu Asn Ile Asn Leu Asn Ser Asp Lys Leu Val Phe Pro 
        115                 120                 125             


Ala Val Thr Ile Cys Thr Leu Asn Pro Tyr Arg Tyr Pro Glu Ile Lys 
    130                 135                 140                 


Glu Glu Leu Glu Glu Leu Asp Arg Ile Thr Glu Gln Thr Leu Phe Asp 
145                 150                 155                 160 


Leu Tyr Lys Tyr Ser Ser Phe Thr Thr Leu Val Ala Gly Ser Arg Ser 
                165                 170                 175     


Arg Arg Asp Leu Arg Gly Thr Leu Pro His Pro Leu Gln Arg Leu Arg 
            180                 185                 190         


Val Pro Pro Pro Pro His Gly Ala Arg Arg Ala Arg Ser Val Ala Ser 
        195                 200                 205             


Ser Leu Arg Asp Asn Asn Pro Gln Val Asp Trp Lys Asp Trp Lys Ile 
    210                 215                 220                 


Gly Phe Gln Leu Cys Asn Gln Asn Lys Ser Asp Cys Phe Tyr Gln Thr 
225                 230                 235                 240 


Tyr Ser Ser Gly Val Asp Ala Val Arg Glu Trp Tyr Arg Phe His Tyr 
                245                 250                 255     


Ile Asn Ile Leu Ser Arg Leu Pro Glu Thr Leu Pro Ser Leu Glu Glu 
            260                 265                 270         


Asp Thr Leu Gly Asn Phe Ile Phe Ala Cys Arg Phe Asn Gln Val Ser 
        275                 280                 285             


Cys Asn Gln Ala Asn Tyr Ser His Phe His His Pro Met Tyr Gly Asn 
    290                 295                 300                 


Cys Tyr Thr Phe Asn Asp Lys Asn Asn Ser Asn Leu Trp Met Ser Ser 
305                 310                 315                 320 


Met Pro Gly Ile Asn Asn Gly Leu Ser Leu Met Leu Arg Ala Glu Gln 
                325                 330                 335     


Asn Asp Phe Ile Pro Leu Leu Ser Thr Val Thr Gly Ala Arg Val Met 
            340                 345                 350         


Val His Gly Gln Asp Glu Pro Ala Phe Met Asp Asp Gly Gly Phe Asn 
        355                 360                 365             


Leu Arg Pro Gly Val Glu Thr Ser Ile Ser Met Arg Lys Glu Thr Leu 
    370                 375                 380                 


Asp Arg Leu Gly Gly Asp Tyr Gly Asp Cys Thr Lys Asn Gly Ser Asp 
385                 390                 395                 400 


Val Pro Val Glu Asn Leu Tyr Pro Ser Lys Tyr Thr Gln Gln Val Cys 
                405                 410                 415     


Ile His Ser Cys Phe Gln Glu Ser Met Ile Lys Glu Cys Gly Cys Ala 
            420                 425                 430         


Tyr Ile Phe Tyr Pro Arg Pro Gln Asn Val Glu Tyr Cys Asp Tyr Arg 
        435                 440                 445             


Lys His Ser Ser Trp Gly Tyr Cys Tyr Tyr Lys Leu Gln Val Asp Phe 
    450                 455                 460                 


Ser Ser Asp His Leu Gly Cys Phe Thr Lys Cys Arg Lys Pro Cys Ser 
465                 470                 475                 480 


Val Thr Ser Tyr Gln Leu Ser Ala Gly Tyr Ser Arg Trp Pro Ser Val 
                485                 490                 495     


Thr Ser Gln Glu Trp Val Phe Gln Met Leu Ser Arg Gln Asn Asn Tyr 
            500                 505                 510         


Thr Val Asn Asn Lys Arg Asn Gly Val Ala Lys Val Asn Ile Phe Phe 
        515                 520                 525             


Lys Glu Leu Asn Tyr Lys Thr Asn Ser Glu Ser Pro Ser Val Thr Met 
    530                 535                 540                 


Val Thr Leu Leu Ser Asn Leu Gly Ser Gln Trp Ser Leu Trp Phe Gly 
545                 550                 555                 560 


Ser Ser Val Leu Ser Val Val Glu Met Ala Glu Leu Val Phe Asp Leu 
                565                 570                 575     


Leu Val Ile Met Phe Leu Met Leu Leu Arg Arg Phe Arg Ser Arg Tyr 
            580                 585                 590         


Trp Ser Pro Gly Arg Gly Gly Arg Gly Ala Gln Glu Val Ala Ser Thr 
        595                 600                 605             


Leu Ala Ser Ser Pro Pro Ser His Phe Cys Pro His Pro Met Ser Leu 
    610                 615                 620                 


Ser Leu Ser Gln Pro Gly Pro Ala Pro Ser Pro Ala Leu Thr Ala Pro 
625                 630                 635                 640 


Pro Pro Ala Tyr Ala Thr Leu Gly Pro Arg Pro Ser Pro Gly Gly Ser 
                645                 650                 655     


Ala Gly Ala Ser Ser Ser Thr Cys Pro Leu Gly Gly Pro 
            660                 665                 


<210>  450
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  450

Met Ser Ser Ile Lys Gly Asn Lys Leu Glu Glu Gln Asp Pro Arg Pro 
1               5                   10                  15      


Leu Gln Pro Ile Pro Gly Leu Met Glu Gly Asn Lys Leu Glu Glu Gln 
            20                  25                  30          


Asp Ser Ser Pro Pro Gln Ser Thr Pro Gly Leu Met Lys Gly Asn Lys 
        35                  40                  45              


Arg Glu Glu Gln Gly Leu Gly Pro Glu Pro Ala Ala Pro Gln Gln Pro 
    50                  55                  60                  


Thr Ala Glu Glu Glu Ala Leu Ile Glu Phe His Arg Ser Tyr Arg Glu 
65                  70                  75                  80  


Leu Phe Glu Phe Phe Cys Asn Asn Thr Thr Ile His Gly Ala Ile Arg 
                85                  90                  95      


Leu Val Cys Ser Gln His Asn Arg Met Lys Thr Ala Phe Trp Ala Val 
            100                 105                 110         


Leu Trp Leu Cys Thr Phe Gly Met Met Tyr Trp Gln Phe Gly Leu Leu 
        115                 120                 125             


Phe Gly Glu Tyr Phe Ser Tyr Pro Val Ser Leu Asn Ile Asn Leu Asn 
    130                 135                 140                 


Ser Asp Lys Leu Val Phe Pro Ala Val Thr Ile Cys Thr Leu Asn Pro 
145                 150                 155                 160 


Tyr Arg Tyr Pro Glu Ile Lys Glu Glu Leu Glu Glu Leu Asp Arg Ile 
                165                 170                 175     


Thr Glu Gln Thr Leu Phe Asp Leu Tyr Lys Tyr Ser Ser Phe Thr Thr 
            180                 185                 190         


Leu Val Ala Gly Ser Arg Ser Arg Arg Asp Leu Arg Gly Thr Leu Pro 
        195                 200                 205             


His Pro Leu Gln Arg Leu Arg Val Pro Pro Pro Pro His Gly Ala Arg 
    210                 215                 220                 


Arg Ala Arg Ser Val Ala Ser Ser Leu Arg Asp Asn Asn Pro Gln Val 
225                 230                 235                 240 


Asp Trp Lys Asp Trp Lys Ile Gly Phe Gln Leu Cys Asn Gln Asn Lys 
                245                 250                 255     


Ser Asp Cys Phe Tyr Gln Thr Tyr Ser Ser Gly Val Asp Ala Val Arg 
            260                 265                 270         


Glu Trp Tyr Arg Phe His Tyr Ile Asn Ile Leu Ser Arg Leu Pro Glu 
        275                 280                 285             


Thr Leu Pro Ser Leu Glu Glu Asp Thr Leu Gly Asn Phe Ile Phe Ala 
    290                 295                 300                 


Cys Arg Phe Asn Gln Val Ser Cys Asn Gln Ala Asn Tyr Ser His Phe 
305                 310                 315                 320 


His His Pro Met Tyr Gly Asn Cys Tyr Thr Phe Asn Asp Lys Asn Asn 
                325                 330                 335     


Ser Asn Leu Trp Met Ser Ser Met Pro Gly Ile Asn Asn Gly Leu Ser 
            340                 345                 350         


Leu Met Leu Arg Ala Glu Gln Asn Asp Phe Ile Pro Leu Leu Ser Thr 
        355                 360                 365             


Val Thr Gly Ala Arg Val Met Val His Gly Gln Asp Glu Pro Ala Phe 
    370                 375                 380                 


Met Asp Asp Gly Gly Phe Asn Leu Arg Pro Gly Val Glu Thr Ser Ile 
385                 390                 395                 400 


Ser Met Arg Lys Glu Thr Leu Asp Arg Leu Gly Gly Asp Tyr Gly Asp 
                405                 410                 415     


Cys Thr Lys Asn Gly Ser Asp Val Pro Val Glu Asn Leu Tyr Pro Ser 
            420                 425                 430         


Lys Tyr Thr Gln Gln Val Cys Ile His Ser Cys Phe Gln Glu Ser Met 
        435                 440                 445             


Ile Lys Glu Cys Gly Cys Ala Tyr Ile Phe Tyr Pro Arg Pro Gln Asn 
    450                 455                 460                 


Val Glu Tyr Cys Asp Tyr Arg Lys His Ser Ser Trp Gly Tyr Cys Tyr 
465                 470                 475                 480 


Tyr Lys Leu Gln Val Asp Phe Ser Ser Asp His Leu Gly Cys Phe Thr 
                485                 490                 495     


Lys Cys Arg Lys Pro Cys Ser Val Thr Ser Tyr Gln Leu Ser Ala Gly 
            500                 505                 510         


Tyr Ser Arg Trp Pro Ser Val Thr Ser Gln Glu Trp Val Phe Gln Met 
        515                 520                 525             


Leu Ser Arg Gln Asn Asn Tyr Thr Val Asn Asn Lys Arg Asn Gly Val 
    530                 535                 540                 


Ala Lys Val Asn Ile Phe Phe Lys Glu Leu Asn Tyr Lys Thr Asn Ser 
545                 550                 555                 560 


Glu Ser Pro Ser Val Thr Met Val Thr Leu Leu Ser Asn Leu Gly Ser 
                565                 570                 575     


Gln Trp Ser Leu Trp Phe Gly Ser Ser Val Leu Ser Val Val Glu Met 
            580                 585                 590         


Ala Glu Leu Val Phe Asp Leu Leu Val Ile Met Phe Leu Met Leu Leu 
        595                 600                 605             


Arg Arg Phe Arg Ser Arg Tyr Trp Ser Pro Gly Arg Gly Gly Arg Gly 
    610                 615                 620                 


Ala Gln Glu Val Ala Ser Thr Leu Ala Ser Ser Pro Pro Ser His Phe 
625                 630                 635                 640 


Cys Pro His Pro Met Ser Leu Ser Leu Ser Gln Pro Gly Pro Ala Pro 
                645                 650                 655     


Ser Pro Ala Leu Thr Ala Pro Pro Pro Ala Tyr Ala Thr Leu Gly Pro 
            660                 665                 670         


Arg Pro Ser Pro Gly Gly Ser Ala Gly Ala Ser Ser Ser Thr Cys Pro 
        675                 680                 685             


Leu Gly Gly Pro 
    690         


<210>  451
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  451

Met Gly Met Ala Arg Gly Ser Leu Thr Arg Val Pro Gly Val Met Gly 
1               5                   10                  15      


Glu Gly Thr Gln Gly Pro Glu Leu Ser Leu Asp Pro Asp Pro Cys Ser 
            20                  25                  30          


Pro Gln Ser Thr Pro Gly Leu Met Lys Gly Asn Lys Leu Glu Glu Gln 
        35                  40                  45              


Asp Pro Arg Pro Leu Gln Pro Ile Pro Gly Leu Met Glu Gly Asn Lys 
    50                  55                  60                  


Leu Glu Glu Gln Asp Ser Ser Pro Pro Gln Ser Thr Pro Gly Leu Met 
65                  70                  75                  80  


Lys Gly Asn Lys Arg Glu Glu Gln Gly Leu Gly Pro Glu Pro Ala Ala 
                85                  90                  95      


Pro Gln Gln Pro Thr Ala Glu Glu Glu Ala Leu Ile Glu Phe His Arg 
            100                 105                 110         


Ser Tyr Arg Glu Leu Phe Glu Phe Phe Cys Asn Asn Thr Thr Ile His 
        115                 120                 125             


Gly Ala Ile Arg Leu Val Cys Ser Gln His Asn Arg Met Lys Thr Ala 
    130                 135                 140                 


Phe Trp Ala Val Leu Trp Leu Cys Thr Phe Gly Met Met Tyr Trp Gln 
145                 150                 155                 160 


Phe Gly Leu Leu Phe Gly Glu Tyr Phe Ser Tyr Pro Val Ser Leu Asn 
                165                 170                 175     


Ile Asn Leu Asn Ser Asp Lys Leu Val Phe Pro Ala Val Thr Ile Cys 
            180                 185                 190         


Thr Leu Asn Pro Tyr Arg Tyr Pro Glu Ile Lys Glu Glu Leu Glu Glu 
        195                 200                 205             


Leu Asp Arg Ile Thr Glu Gln Thr Leu Phe Asp Leu Tyr Lys Tyr Ser 
    210                 215                 220                 


Ser Phe Thr Thr Leu Val Ala Gly Ser Arg Ser Arg Arg Asp Leu Arg 
225                 230                 235                 240 


Gly Thr Leu Pro His Pro Leu Gln Arg Leu Arg Val Pro Pro Pro Pro 
                245                 250                 255     


His Gly Ala Arg Arg Ala Arg Ser Val Ala Ser Ser Leu Arg Asp Asn 
            260                 265                 270         


Asn Pro Gln Val Asp Trp Lys Asp Trp Lys Ile Gly Phe Gln Leu Cys 
        275                 280                 285             


Asn Gln Asn Lys Ser Asp Cys Phe Tyr Gln Thr Tyr Ser Ser Gly Val 
    290                 295                 300                 


Asp Ala Val Arg Glu Trp Tyr Arg Phe His Tyr Ile Asn Ile Leu Ser 
305                 310                 315                 320 


Arg Leu Pro Glu Thr Leu Pro Ser Leu Glu Glu Asp Thr Leu Gly Asn 
                325                 330                 335     


Phe Ile Phe Ala Cys Arg Phe Asn Gln Val Ser Cys Asn Gln Ala Asn 
            340                 345                 350         


Tyr Ser His Phe His His Pro Met Tyr Gly Asn Cys Tyr Thr Phe Asn 
        355                 360                 365             


Asp Lys Asn Asn Ser Asn Leu Trp Met Ser Ser Met Pro Gly Ile Asn 
    370                 375                 380                 


Asn Gly Leu Ser Leu Met Leu Arg Ala Glu Gln Asn Asp Phe Ile Pro 
385                 390                 395                 400 


Leu Leu Ser Thr Val Thr Gly Ala Arg Val Met Val His Gly Gln Asp 
                405                 410                 415     


Glu Pro Ala Phe Met Asp Asp Gly Gly Phe Asn Leu Arg Pro Gly Val 
            420                 425                 430         


Glu Thr Ser Ile Ser Met Arg Lys Glu Thr Leu Asp Arg Leu Gly Gly 
        435                 440                 445             


Asp Tyr Gly Asp Cys Thr Lys Asn Gly Ser Asp Val Pro Val Glu Asn 
    450                 455                 460                 


Leu Tyr Pro Ser Lys Tyr Thr Gln Gln Val Cys Ile His Ser Cys Phe 
465                 470                 475                 480 


Gln Glu Ser Met Ile Lys Glu Cys Gly Cys Ala Tyr Ile Phe Tyr Pro 
                485                 490                 495     


Arg Pro Gln Asn Val Glu Tyr Cys Asp Tyr Arg Lys His Ser Ser Trp 
            500                 505                 510         


Gly Tyr Cys Tyr Tyr Lys Leu Gln Val Asp Phe Ser Ser Asp His Leu 
        515                 520                 525             


Gly Cys Phe Thr Lys Cys Arg Lys Pro Cys Ser Val Thr Ser Tyr Gln 
    530                 535                 540                 


Leu Ser Ala Gly Tyr Ser Arg Trp Pro Ser Val Thr Ser Gln Glu Trp 
545                 550                 555                 560 


Val Phe Gln Met Leu Ser Arg Gln Asn Asn Tyr Thr Val Asn Asn Lys 
                565                 570                 575     


Arg Asn Gly Val Ala Lys Val Asn Ile Phe Phe Lys Glu Leu Asn Tyr 
            580                 585                 590         


Lys Thr Asn Ser Glu Ser Pro Ser Val Thr Met Val Thr Leu Leu Ser 
        595                 600                 605             


Asn Leu Gly Ser Gln Trp Ser Leu Trp Phe Gly Ser Ser Val Leu Ser 
    610                 615                 620                 


Val Val Glu Met Ala Glu Leu Val Phe Asp Leu Leu Val Ile Met Phe 
625                 630                 635                 640 


Leu Met Leu Leu Arg Arg Phe Arg Ser Arg Tyr Trp Ser Pro Gly Arg 
                645                 650                 655     


Gly Gly Arg Gly Ala Gln Glu Val Ala Ser Thr Leu Ala Ser Ser Pro 
            660                 665                 670         


Pro Ser His Phe Cys Pro His Pro Met Ser Leu Ser Leu Ser Gln Pro 
        675                 680                 685             


Gly Pro Ala Pro Ser Pro Ala Leu Thr Ala Pro Pro Pro Ala Tyr Ala 
    690                 695                 700                 


Thr Leu Gly Pro Arg Pro Ser Pro Gly Gly Ser Ala Gly Ala Ser Ser 
705                 710                 715                 720 


Ser Thr Cys Pro Leu Gly Gly Pro 
                725             


<210>  452
<211>  1074
<212>  PRT
<213>  Homo sapiens

<400>  452

Met Lys Gly Thr Cys Val Ile Ala Trp Leu Phe Ser Ser Leu Gly Leu 
1               5                   10                  15      


Trp Arg Leu Ala His Pro Glu Ala Gln Gly Thr Thr Gln Cys Gln Arg 
            20                  25                  30          


Thr Glu His Pro Val Ile Ser Tyr Lys Glu Ile Gly Pro Trp Leu Arg 
        35                  40                  45              


Glu Phe Arg Ala Lys Asn Ala Val Asp Phe Ser Gln Leu Thr Phe Asp 
    50                  55                  60                  


Pro Gly Gln Lys Glu Leu Val Val Gly Ala Arg Asn Tyr Leu Phe Arg 
65                  70                  75                  80  


Leu Gln Leu Glu Asp Leu Ser Leu Ile Gln Ala Val Glu Trp Glu Cys 
                85                  90                  95      


Asp Glu Ala Thr Lys Lys Ala Cys Tyr Ser Lys Gly Lys Ser Lys Glu 
            100                 105                 110         


Glu Cys Gln Asn Tyr Ile Arg Val Leu Leu Val Gly Gly Asp Arg Leu 
        115                 120                 125             


Phe Thr Cys Gly Thr Asn Ala Phe Thr Pro Val Cys Thr Asn Arg Ser 
    130                 135                 140                 


Leu Ser Asn Leu Thr Glu Ile His Asp Gln Ile Ser Gly Met Ala Arg 
145                 150                 155                 160 


Cys Pro Tyr Ser Pro Gln His Asn Ser Thr Ala Leu Leu Thr Ala Gly 
                165                 170                 175     


Gly Glu Leu Tyr Ala Ala Thr Ala Met Asp Phe Pro Gly Arg Asp Pro 
            180                 185                 190         


Ala Ile Tyr Arg Ser Leu Gly Ile Leu Pro Pro Leu Arg Thr Ala Gln 
        195                 200                 205             


Tyr Asn Ser Lys Trp Leu Asn Glu Pro Asn Phe Val Ser Ser Tyr Asp 
    210                 215                 220                 


Ile Gly Asn Phe Thr Tyr Phe Phe Phe Arg Glu Asn Ala Val Glu His 
225                 230                 235                 240 


Asp Cys Gly Lys Thr Val Phe Ser Arg Ala Ala Arg Val Cys Lys Asn 
                245                 250                 255     


Asp Ile Gly Gly Arg Phe Leu Leu Glu Asp Thr Trp Thr Thr Phe Met 
            260                 265                 270         


Lys Ala Arg Leu Asn Cys Ser Arg Pro Gly Glu Val Pro Phe Tyr Tyr 
        275                 280                 285             


Asn Glu Leu Gln Ser Thr Phe Phe Leu Pro Glu Leu Asp Leu Ile Tyr 
    290                 295                 300                 


Gly Ile Phe Thr Thr Asn Val Asn Ser Ile Ala Ala Ser Ala Val Cys 
305                 310                 315                 320 


Val Phe Asn Leu Ser Ala Ile Ala Gln Ala Phe Ser Gly Pro Phe Lys 
                325                 330                 335     


Tyr Gln Glu Asn Ser Arg Ser Ala Trp Leu Pro Tyr Pro Asn Pro Asn 
            340                 345                 350         


Pro His Phe Gln Cys Gly Thr Val Asp Gln Gly Leu Tyr Val Asn Leu 
        355                 360                 365             


Thr Glu Arg Asn Leu Gln Asp Ala Gln Lys Phe Ile Leu Met His Glu 
    370                 375                 380                 


Val Val Gln Pro Val Thr Thr Val Pro Ser Phe Met Glu Asp Asn Ser 
385                 390                 395                 400 


Arg Phe Ser His Val Ala Val Asp Val Val Gln Gly Arg Glu Ala Leu 
                405                 410                 415     


Val His Ile Ile Tyr Leu Ala Thr Asp Tyr Gly Thr Ile Lys Lys Val 
            420                 425                 430         


Arg Val Pro Leu Asn Gln Thr Ser Ser Ser Cys Leu Leu Glu Glu Ile 
        435                 440                 445             


Glu Leu Phe Pro Glu Arg Arg Arg Glu Pro Ile Arg Ser Leu Gln Ile 
    450                 455                 460                 


Leu His Ser Gln Ser Val Leu Phe Val Gly Leu Arg Glu His Val Val 
465                 470                 475                 480 


Lys Ile Pro Leu Lys Arg Cys Gln Phe Tyr Arg Thr Arg Ser Thr Cys 
                485                 490                 495     


Ile Gly Ala Gln Asp Pro Tyr Cys Gly Trp Asp Val Val Met Lys Lys 
            500                 505                 510         


Cys Thr Ser Leu Glu Glu Ser Leu Ser Met Thr Gln Trp Glu Gln Ser 
        515                 520                 525             


Ile Ser Ala Cys Pro Thr Arg Asn Leu Thr Val Asp Gly His Phe Gly 
    530                 535                 540                 


Val Trp Ser Pro Trp Thr Pro Cys Thr His Thr Asp Gly Ser Ala Val 
545                 550                 555                 560 


Gly Ser Cys Leu Cys Arg Thr Arg Ser Cys Asp Ser Pro Ala Pro Gln 
                565                 570                 575     


Cys Gly Gly Trp Gln Cys Glu Gly Pro Gly Met Glu Ile Ala Asn Cys 
            580                 585                 590         


Ser Arg Asn Gly Gly Trp Thr Pro Trp Thr Ser Trp Ser Pro Cys Ser 
        595                 600                 605             


Thr Thr Cys Gly Ile Gly Phe Gln Val Arg Gln Arg Ser Cys Ser Asn 
    610                 615                 620                 


Pro Thr Pro Arg His Gly Gly Arg Val Cys Val Gly Gln Asn Arg Glu 
625                 630                 635                 640 


Glu Arg Tyr Cys Asn Glu His Leu Leu Cys Pro Pro His Met Phe Trp 
                645                 650                 655     


Thr Gly Trp Gly Pro Trp Glu Arg Cys Thr Ala Gln Cys Gly Gly Gly 
            660                 665                 670         


Ile Gln Ala Arg Arg Arg Ile Cys Glu Asn Gly Pro Asp Cys Ala Gly 
        675                 680                 685             


Cys Asn Val Glu Tyr Gln Ser Cys Asn Thr Asn Pro Cys Pro Glu Leu 
    690                 695                 700                 


Lys Lys Thr Thr Pro Trp Thr Pro Trp Thr Pro Val Asn Ile Ser Asp 
705                 710                 715                 720 


Asn Gly Gly His Tyr Glu Gln Arg Phe Arg Tyr Thr Cys Lys Ala Arg 
                725                 730                 735     


Leu Ala Asp Pro Asn Leu Leu Glu Val Gly Arg Gln Arg Ile Glu Met 
            740                 745                 750         


Arg Tyr Cys Ser Ser Asp Gly Thr Ser Gly Cys Ser Thr Asp Gly Leu 
        755                 760                 765             


Ser Gly Asp Phe Leu Arg Ala Gly Arg Tyr Ser Ala His Thr Val Asn 
    770                 775                 780                 


Gly Ala Trp Ser Ala Trp Thr Ser Trp Ser Gln Cys Ser Arg Asp Cys 
785                 790                 795                 800 


Ser Arg Gly Ile Arg Asn Arg Lys Arg Val Cys Asn Asn Pro Glu Pro 
                805                 810                 815     


Lys Tyr Gly Gly Met Pro Cys Leu Gly Pro Ser Leu Glu Tyr Gln Glu 
            820                 825                 830         


Cys Asn Ile Leu Pro Cys Pro Val Asp Gly Val Trp Ser Cys Trp Ser 
        835                 840                 845             


Pro Trp Thr Lys Cys Ser Ala Thr Cys Gly Gly Gly His Tyr Met Arg 
    850                 855                 860                 


Thr Arg Ser Cys Ser Asn Pro Ala Pro Ala Tyr Gly Gly Asp Ile Cys 
865                 870                 875                 880 


Leu Gly Leu His Thr Glu Glu Ala Leu Cys Asn Thr Gln Pro Cys Pro 
                885                 890                 895     


Glu Ser Trp Ser Glu Trp Ser Asp Trp Ser Glu Cys Glu Ala Ser Gly 
            900                 905                 910         


Val Gln Val Arg Ala Arg Gln Cys Ile Leu Leu Phe Pro Met Gly Ser 
        915                 920                 925             


Gln Cys Ser Gly Asn Thr Thr Glu Ser Arg Pro Cys Val Phe Asp Ser 
    930                 935                 940                 


Asn Phe Ile Pro Glu Val Ser Val Ala Arg Ser Ser Ser Val Glu Glu 
945                 950                 955                 960 


Lys Arg Cys Gly Glu Phe Asn Met Phe His Met Ile Ala Val Gly Leu 
                965                 970                 975     


Ser Ser Ser Ile Leu Gly Cys Leu Leu Thr Leu Leu Val Tyr Thr Tyr 
            980                 985                 990         


Cys Gln Arg Tyr Gln Gln Gln Ser  His Asp Ala Thr Val  Ile His Pro 
        995                 1000                 1005             


Val Ser  Pro Ala Pro Leu Asn  Thr Ser Ile Thr Asn  His Ile Asn 
    1010                 1015                 1020             


Lys Leu  Asp Lys Tyr Asp Ser  Val Glu Ala Ile Lys  Ala Phe Asn 
    1025                 1030                 1035             


Lys Asn  Asn Leu Ile Leu Glu  Glu Arg Asn Lys Tyr  Phe Asn Pro 
    1040                 1045                 1050             


His Leu  Thr Gly Lys Thr Tyr  Ser Asn Ala Tyr Phe  Thr Asp Leu 
    1055                 1060                 1065             


Asn Asn  Tyr Asp Glu Tyr 
    1070                 


<210>  453
<211>  1151
<212>  PRT
<213>  Homo sapiens

<400>  453

Met Pro Cys Gly Phe Ser Pro Ser Pro Val Ala His His Leu Val Pro 
1               5                   10                  15      


Gly Pro Pro Asp Thr Pro Ala Gln Gln Leu Arg Cys Gly Trp Thr Val 
            20                  25                  30          


Gly Gly Trp Leu Leu Ser Leu Val Arg Gly Leu Leu Pro Cys Leu Pro 
        35                  40                  45              


Pro Gly Ala Arg Thr Ala Glu Gly Pro Ile Met Val Leu Ala Gly Pro 
    50                  55                  60                  


Leu Ala Val Ser Leu Leu Leu Pro Ser Leu Thr Leu Leu Val Ser His 
65                  70                  75                  80  


Leu Ser Ser Ser Gln Asp Val Ser Ser Glu Pro Ser Ser Glu Gln Gln 
                85                  90                  95      


Leu Cys Ala Leu Ser Lys His Pro Thr Val Ala Phe Glu Asp Leu Gln 
            100                 105                 110         


Pro Trp Val Ser Asn Phe Thr Tyr Pro Gly Ala Arg Asp Phe Ser Gln 
        115                 120                 125             


Leu Ala Leu Asp Pro Ser Gly Asn Gln Leu Ile Val Gly Ala Arg Asn 
    130                 135                 140                 


Tyr Leu Phe Arg Leu Ser Leu Ala Asn Val Ser Leu Leu Gln Ala Thr 
145                 150                 155                 160 


Glu Trp Ala Ser Ser Glu Asp Thr Arg Arg Ser Cys Gln Ser Lys Gly 
                165                 170                 175     


Lys Thr Glu Glu Glu Cys Gln Asn Tyr Val Arg Val Leu Ile Val Ala 
            180                 185                 190         


Gly Arg Lys Val Phe Met Cys Gly Thr Asn Ala Phe Ser Pro Met Cys 
        195                 200                 205             


Thr Ser Arg Gln Val Gly Asn Leu Ser Arg Thr Ile Glu Lys Ile Asn 
    210                 215                 220                 


Gly Val Ala Arg Cys Pro Tyr Asp Pro Arg His Asn Ser Thr Ala Val 
225                 230                 235                 240 


Ile Ser Ser Gln Gly Glu Leu Tyr Ala Ala Thr Val Ile Asp Phe Ser 
                245                 250                 255     


Gly Arg Asp Pro Ala Ile Tyr Arg Ser Leu Gly Ser Gly Pro Pro Leu 
            260                 265                 270         


Arg Thr Ala Gln Tyr Asn Ser Lys Trp Leu Asn Glu Pro Asn Phe Val 
        275                 280                 285             


Ala Ala Tyr Asp Ile Gly Leu Phe Ala Tyr Phe Phe Leu Arg Glu Asn 
    290                 295                 300                 


Ala Val Glu His Asp Cys Gly Arg Thr Val Tyr Ser Arg Val Ala Arg 
305                 310                 315                 320 


Val Cys Lys Asn Asp Val Gly Gly Arg Phe Leu Leu Glu Asp Thr Trp 
                325                 330                 335     


Thr Thr Phe Met Lys Ala Arg Leu Asn Cys Ser Arg Pro Gly Glu Val 
            340                 345                 350         


Pro Phe Tyr Tyr Asn Glu Leu Gln Ser Ala Phe His Leu Pro Glu Gln 
        355                 360                 365             


Asp Leu Ile Tyr Gly Val Phe Thr Thr Asn Val Asn Ser Ile Ala Ala 
    370                 375                 380                 


Ser Ala Val Cys Ala Phe Asn Leu Ser Ala Ile Ser Gln Ala Phe Asn 
385                 390                 395                 400 


Gly Pro Phe Arg Tyr Gln Glu Asn Pro Arg Ala Ala Trp Leu Pro Ile 
                405                 410                 415     


Ala Asn Pro Ile Pro Asn Phe Gln Cys Gly Thr Leu Pro Glu Thr Gly 
            420                 425                 430         


Pro Asn Glu Asn Leu Thr Glu Arg Ser Leu Gln Asp Ala Gln Arg Leu 
        435                 440                 445             


Phe Leu Met Ser Glu Ala Val Gln Pro Val Thr Pro Glu Pro Cys Val 
    450                 455                 460                 


Thr Gln Asp Ser Val Arg Phe Ser His Leu Val Val Asp Leu Val Gln 
465                 470                 475                 480 


Ala Lys Asp Thr Leu Tyr His Val Leu Tyr Ile Gly Thr Glu Ser Gly 
                485                 490                 495     


Thr Ile Leu Lys Ala Leu Ser Thr Ala Ser Arg Ser Leu His Gly Cys 
            500                 505                 510         


Tyr Leu Glu Glu Leu His Val Leu Pro Pro Gly Arg Arg Glu Pro Leu 
        515                 520                 525             


Arg Ser Leu Arg Ile Leu His Ser Ala Arg Ala Leu Phe Val Gly Leu 
    530                 535                 540                 


Arg Asp Gly Val Leu Arg Val Pro Leu Glu Arg Cys Ala Ala Tyr Arg 
545                 550                 555                 560 


Ser Gln Gly Ala Cys Leu Gly Ala Arg Asp Pro Tyr Cys Gly Trp Asp 
                565                 570                 575     


Gly Lys Gln Gln Arg Cys Ser Thr Leu Glu Asp Ser Ser Asn Met Ser 
            580                 585                 590         


Leu Trp Thr Gln Asn Ile Thr Ala Cys Pro Val Arg Asn Val Thr Arg 
        595                 600                 605             


Asp Gly Gly Phe Gly Pro Trp Ser Pro Trp Gln Pro Cys Glu His Leu 
    610                 615                 620                 


Asp Gly Asp Asn Ser Gly Ser Cys Leu Cys Arg Ala Arg Ser Cys Asp 
625                 630                 635                 640 


Ser Pro Arg Pro Arg Cys Gly Gly Leu Asp Cys Leu Gly Pro Ala Ile 
                645                 650                 655     


His Ile Ala Asn Cys Ser Arg Asn Gly Ala Trp Thr Pro Trp Ser Ser 
            660                 665                 670         


Trp Ala Leu Cys Ser Thr Ser Cys Gly Ile Gly Phe Gln Val Arg Gln 
        675                 680                 685             


Arg Ser Cys Ser Asn Pro Ala Pro Arg His Gly Gly Arg Ile Cys Val 
    690                 695                 700                 


Gly Lys Ser Arg Glu Glu Arg Phe Cys Asn Glu Asn Thr Pro Cys Pro 
705                 710                 715                 720 


Val Pro Ile Phe Trp Ala Ser Trp Gly Ser Trp Ser Lys Cys Ser Ser 
                725                 730                 735     


Asn Cys Gly Gly Gly Met Gln Ser Arg Arg Arg Ala Cys Glu Asn Gly 
            740                 745                 750         


Asn Ser Cys Leu Gly Cys Gly Val Glu Phe Lys Thr Cys Asn Pro Glu 
        755                 760                 765             


Gly Cys Pro Glu Val Arg Arg Asn Thr Pro Trp Thr Pro Trp Leu Pro 
    770                 775                 780                 


Val Asn Val Thr Gln Gly Gly Ala Arg Gln Glu Gln Arg Phe Arg Phe 
785                 790                 795                 800 


Thr Cys Arg Ala Pro Leu Ala Asp Pro His Gly Leu Gln Phe Gly Arg 
                805                 810                 815     


Arg Arg Thr Glu Thr Arg Thr Cys Pro Ala Asp Gly Ser Gly Ser Cys 
            820                 825                 830         


Asp Thr Asp Ala Leu Val Glu Val Leu Leu Arg Ser Gly Ser Thr Ser 
        835                 840                 845             


Pro His Thr Val Ser Gly Gly Trp Ala Ala Trp Gly Pro Trp Ser Ser 
    850                 855                 860                 


Cys Ser Arg Asp Cys Glu Leu Gly Phe Arg Val Arg Lys Arg Thr Cys 
865                 870                 875                 880 


Thr Asn Pro Glu Pro Arg Asn Gly Gly Leu Pro Cys Val Gly Asp Ala 
                885                 890                 895     


Ala Glu Tyr Gln Asp Cys Asn Pro Gln Ala Cys Pro Val Arg Gly Ala 
            900                 905                 910         


Trp Ser Cys Trp Thr Ser Trp Ser Pro Cys Ser Ala Ser Cys Gly Gly 
        915                 920                 925             


Gly His Tyr Gln Arg Thr Arg Ser Cys Thr Ser Pro Ala Pro Ser Pro 
    930                 935                 940                 


Gly Glu Asp Ile Cys Leu Gly Leu His Thr Glu Glu Ala Leu Cys Ala 
945                 950                 955                 960 


Thr Gln Ala Cys Pro Glu Gly Trp Ser Pro Trp Ser Glu Trp Ser Lys 
                965                 970                 975     


Cys Thr Asp Asp Gly Ala Gln Ser Arg Ser Arg His Cys Glu Glu Leu 
            980                 985                 990         


Leu Pro Gly Ser Ser Ala Cys Ala  Gly Asn Ser Ser Gln  Ser Arg Pro 
        995                 1000                 1005             


Cys Pro  Tyr Ser Glu Ile Pro  Val Ile Leu Pro Ala  Ser Ser Met 
    1010                 1015                 1020             


Glu Glu  Ala Thr Asp Cys Ala  Gly Phe Asn Leu Ile  His Leu Val 
    1025                 1030                 1035             


Ala Thr  Gly Ile Ser Cys Phe  Leu Gly Ser Gly Leu  Leu Thr Leu 
    1040                 1045                 1050             


Ala Val  Tyr Leu Ser Cys Gln  His Cys Gln Arg Gln  Ser Gln Glu 
    1055                 1060                 1065             


Ser Thr  Leu Val His Pro Ala  Thr Pro Asn His Leu  His Tyr Lys 
    1070                 1075                 1080             


Gly Gly  Gly Thr Pro Lys Asn  Glu Lys Tyr Thr Pro  Met Glu Phe 
    1085                 1090                 1095             


Lys Thr  Leu Asn Lys Asn Asn  Leu Ile Pro Asp Asp  Arg Ala Asn 
    1100                 1105                 1110             


Phe Tyr  Pro Leu Gln Gln Thr  Asn Val Tyr Thr Thr  Thr Tyr Tyr 
    1115                 1120                 1125             


Pro Ser  Pro Leu Asn Lys His  Ser Phe Arg Pro Glu  Ala Ser Pro 
    1130                 1135                 1140             


Gly Gln  Arg Cys Phe Pro Asn  Ser 
    1145                 1150     


<210>  454
<211>  1151
<212>  PRT
<213>  Homo sapiens

<400>  454

Met Pro Cys Gly Phe Ser Pro Ser Pro Val Ala His His Leu Val Pro 
1               5                   10                  15      


Gly Pro Pro Asp Thr Pro Ala Gln Gln Leu Arg Cys Gly Trp Thr Val 
            20                  25                  30          


Gly Gly Trp Leu Leu Ser Leu Val Arg Gly Leu Leu Pro Cys Leu Pro 
        35                  40                  45              


Pro Gly Ala Arg Thr Ala Glu Gly Pro Ile Met Val Leu Ala Gly Pro 
    50                  55                  60                  


Leu Ala Val Ser Leu Leu Leu Pro Ser Leu Thr Leu Leu Val Ser His 
65                  70                  75                  80  


Leu Ser Ser Ser Gln Asp Val Ser Ser Glu Pro Ser Ser Glu Gln Gln 
                85                  90                  95      


Leu Cys Ala Leu Ser Lys His Pro Thr Val Ala Phe Glu Asp Leu Gln 
            100                 105                 110         


Pro Trp Val Ser Asn Phe Thr Tyr Pro Gly Ala Arg Asp Phe Ser Gln 
        115                 120                 125             


Leu Ala Leu Asp Pro Ser Gly Asn Gln Leu Ile Val Gly Ala Arg Asn 
    130                 135                 140                 


Tyr Leu Phe Arg Leu Ser Leu Ala Asn Val Ser Leu Leu Gln Ala Thr 
145                 150                 155                 160 


Glu Trp Ala Ser Ser Glu Asp Thr Arg Arg Ser Cys Gln Ser Lys Gly 
                165                 170                 175     


Lys Thr Glu Glu Glu Cys Gln Asn Tyr Val Arg Val Leu Ile Val Ala 
            180                 185                 190         


Gly Arg Lys Val Phe Met Cys Gly Thr Asn Ala Phe Ser Pro Met Cys 
        195                 200                 205             


Thr Ser Arg Gln Val Gly Asn Leu Ser Arg Thr Ile Glu Lys Ile Asn 
    210                 215                 220                 


Gly Val Ala Arg Cys Pro Tyr Asp Pro Arg His Asn Ser Thr Ala Val 
225                 230                 235                 240 


Ile Ser Ser Gln Gly Glu Leu Tyr Ala Ala Thr Val Ile Asp Phe Ser 
                245                 250                 255     


Gly Arg Asp Pro Ala Ile Tyr Arg Ser Leu Gly Ser Gly Pro Pro Leu 
            260                 265                 270         


Arg Thr Ala Gln Tyr Asn Ser Lys Trp Leu Asn Glu Pro Asn Phe Val 
        275                 280                 285             


Ala Ala Tyr Asp Ile Gly Leu Phe Ala Tyr Phe Phe Leu Arg Glu Asn 
    290                 295                 300                 


Ala Val Glu His Asp Cys Gly Arg Thr Val Tyr Ser Arg Val Ala Arg 
305                 310                 315                 320 


Val Cys Lys Asn Asp Val Gly Gly Arg Phe Leu Leu Glu Asp Thr Trp 
                325                 330                 335     


Thr Thr Phe Met Lys Ala Arg Leu Asn Cys Ser Arg Pro Gly Glu Val 
            340                 345                 350         


Pro Phe Tyr Tyr Asn Glu Leu Gln Ser Ala Phe His Leu Pro Glu Gln 
        355                 360                 365             


Asp Leu Ile Tyr Gly Val Phe Thr Thr Asn Val Asn Ser Ile Ala Ala 
    370                 375                 380                 


Ser Ala Val Cys Ala Phe Asn Leu Ser Ala Ile Ser Gln Ala Phe Asn 
385                 390                 395                 400 


Gly Pro Phe Arg Tyr Gln Glu Asn Pro Arg Ala Ala Trp Leu Pro Ile 
                405                 410                 415     


Ala Asn Pro Ile Pro Asn Phe Gln Cys Gly Thr Leu Pro Glu Thr Gly 
            420                 425                 430         


Pro Asn Glu Asn Leu Thr Glu Arg Ser Leu Gln Asp Ala Gln Arg Leu 
        435                 440                 445             


Phe Leu Met Ser Glu Ala Val Gln Pro Val Thr Pro Glu Pro Cys Val 
    450                 455                 460                 


Thr Gln Asp Ser Val Arg Phe Ser His Leu Val Val Asp Leu Val Gln 
465                 470                 475                 480 


Ala Lys Asp Thr Leu Tyr His Val Leu Tyr Ile Gly Thr Glu Ser Gly 
                485                 490                 495     


Thr Ile Leu Lys Ala Leu Ser Thr Ala Ser Arg Ser Leu His Gly Cys 
            500                 505                 510         


Tyr Leu Glu Glu Leu His Val Leu Pro Pro Gly Arg Arg Glu Pro Leu 
        515                 520                 525             


Arg Ser Leu Arg Ile Leu His Ser Ala Arg Ala Leu Phe Val Gly Leu 
    530                 535                 540                 


Arg Asp Gly Val Leu Arg Val Pro Leu Glu Arg Cys Ala Ala Tyr Arg 
545                 550                 555                 560 


Ser Gln Gly Ala Cys Leu Gly Ala Arg Asp Pro Tyr Cys Gly Trp Asp 
                565                 570                 575     


Gly Lys Gln Gln Arg Cys Ser Thr Leu Glu Asp Ser Ser Asn Met Ser 
            580                 585                 590         


Leu Trp Thr Gln Asn Ile Thr Ala Cys Pro Val Arg Asn Val Thr Arg 
        595                 600                 605             


Asp Gly Gly Phe Gly Pro Trp Ser Pro Trp Gln Pro Cys Glu His Leu 
    610                 615                 620                 


Asp Gly Asp Asn Ser Gly Ser Cys Leu Cys Arg Ala Arg Ser Cys Asp 
625                 630                 635                 640 


Ser Pro Arg Pro Arg Cys Gly Gly Leu Asp Cys Leu Gly Pro Ala Ile 
                645                 650                 655     


His Ile Ala Asn Cys Ser Arg Asn Gly Ala Trp Thr Pro Trp Ser Ser 
            660                 665                 670         


Trp Ala Leu Cys Ser Thr Ser Cys Gly Ile Gly Phe Gln Val Arg Gln 
        675                 680                 685             


Arg Ser Cys Ser Asn Pro Ala Pro Arg His Gly Gly Arg Ile Cys Val 
    690                 695                 700                 


Gly Lys Ser Arg Glu Glu Arg Phe Cys Asn Glu Asn Thr Pro Cys Pro 
705                 710                 715                 720 


Val Pro Ile Phe Trp Ala Ser Trp Gly Ser Trp Ser Lys Cys Ser Ser 
                725                 730                 735     


Asn Cys Gly Gly Gly Met Gln Ser Arg Arg Arg Ala Cys Glu Asn Gly 
            740                 745                 750         


Asn Ser Cys Leu Gly Cys Gly Val Glu Phe Lys Thr Cys Asn Pro Glu 
        755                 760                 765             


Gly Cys Pro Glu Val Arg Arg Asn Thr Pro Trp Thr Pro Trp Leu Pro 
    770                 775                 780                 


Val Asn Val Thr Gln Gly Gly Ala Arg Gln Glu Gln Arg Phe Arg Phe 
785                 790                 795                 800 


Thr Cys Arg Ala Pro Leu Ala Asp Pro His Gly Leu Gln Phe Gly Arg 
                805                 810                 815     


Arg Arg Thr Glu Thr Arg Thr Cys Pro Ala Asp Gly Ser Gly Ser Cys 
            820                 825                 830         


Asp Thr Asp Ala Leu Val Glu Val Leu Leu Arg Ser Gly Ser Thr Ser 
        835                 840                 845             


Pro His Thr Val Ser Gly Gly Trp Ala Ala Trp Gly Pro Trp Ser Ser 
    850                 855                 860                 


Cys Ser Arg Asp Cys Glu Leu Gly Phe Arg Val Arg Lys Arg Thr Cys 
865                 870                 875                 880 


Thr Asn Pro Glu Pro Arg Asn Gly Gly Leu Pro Cys Val Gly Asp Ala 
                885                 890                 895     


Ala Glu Tyr Gln Asp Cys Asn Pro Gln Ala Cys Pro Val Arg Gly Ala 
            900                 905                 910         


Trp Ser Cys Trp Thr Ser Trp Ser Pro Cys Ser Ala Ser Cys Gly Gly 
        915                 920                 925             


Gly His Tyr Gln Arg Thr Arg Ser Cys Thr Ser Pro Ala Pro Ser Pro 
    930                 935                 940                 


Gly Glu Asp Ile Cys Leu Gly Leu His Thr Glu Glu Ala Leu Cys Ala 
945                 950                 955                 960 


Thr Gln Ala Cys Pro Glu Gly Trp Ser Pro Trp Ser Glu Trp Ser Lys 
                965                 970                 975     


Cys Thr Asp Asp Gly Ala Gln Ser Arg Ser Arg His Cys Glu Glu Leu 
            980                 985                 990         


Leu Pro Gly Ser Ser Ala Cys Ala  Gly Asn Ser Ser Gln  Ser Arg Pro 
        995                 1000                 1005             


Cys Pro  Tyr Ser Glu Ile Pro  Val Ile Leu Pro Ala  Ser Ser Met 
    1010                 1015                 1020             


Glu Glu  Ala Thr Asp Cys Ala  Gly Phe Asn Leu Ile  His Leu Val 
    1025                 1030                 1035             


Ala Thr  Gly Ile Ser Cys Phe  Leu Gly Ser Gly Leu  Leu Thr Leu 
    1040                 1045                 1050             


Ala Val  Tyr Leu Ser Cys Gln  His Cys Gln Arg Gln  Ser Gln Glu 
    1055                 1060                 1065             


Ser Thr  Leu Val His Pro Ala  Thr Pro Asn His Leu  His Tyr Lys 
    1070                 1075                 1080             


Gly Gly  Gly Thr Pro Lys Asn  Glu Lys Tyr Thr Pro  Met Glu Phe 
    1085                 1090                 1095             


Lys Thr  Leu Asn Lys Asn Asn  Leu Ile Pro Asp Asp  Arg Ala Asn 
    1100                 1105                 1110             


Phe Tyr  Pro Leu Gln Gln Thr  Asn Val Tyr Thr Thr  Thr Tyr Tyr 
    1115                 1120                 1125             


Pro Ser  Pro Leu Asn Lys His  Ser Phe Arg Pro Glu  Ala Ser Pro 
    1130                 1135                 1140             


Gly Gln  Arg Cys Phe Pro Asn  Ser 
    1145                 1150     


<210>  455
<211>  1205
<212>  PRT
<213>  Homo sapiens

<400>  455

Met Leu His Leu Ser Ala Glu Glu Ala Ile Gly Cys Val Arg Val Arg 
1               5                   10                  15      


Arg Ser Phe Ile Asp Glu Leu Ala Phe Gly Arg Gly His Ser Thr Gly 
            20                  25                  30          


Thr Gly Lys Gln Lys Arg Arg Asp Arg Val Ser Gly Ser Ser Trp Cys 
        35                  40                  45              


Leu Ala Cys Val Ser Trp Met Pro Cys Gly Phe Ser Pro Ser Pro Val 
    50                  55                  60                  


Ala His His Leu Val Pro Gly Pro Pro Asp Thr Pro Ala Gln Gln Leu 
65                  70                  75                  80  


Arg Cys Gly Trp Thr Val Gly Gly Trp Leu Leu Ser Leu Val Arg Gly 
                85                  90                  95      


Leu Leu Pro Cys Leu Pro Pro Gly Ala Arg Thr Ala Glu Gly Pro Ile 
            100                 105                 110         


Met Val Leu Ala Gly Pro Leu Ala Val Ser Leu Leu Leu Pro Ser Leu 
        115                 120                 125             


Thr Leu Leu Val Ser His Leu Ser Ser Ser Gln Asp Val Ser Ser Glu 
    130                 135                 140                 


Pro Ser Ser Glu Gln Gln Leu Cys Ala Leu Ser Lys His Pro Thr Val 
145                 150                 155                 160 


Ala Phe Glu Asp Leu Gln Pro Trp Val Ser Asn Phe Thr Tyr Pro Gly 
                165                 170                 175     


Ala Arg Asp Phe Ser Gln Leu Ala Leu Asp Pro Ser Gly Asn Gln Leu 
            180                 185                 190         


Ile Val Gly Ala Arg Asn Tyr Leu Phe Arg Leu Ser Leu Ala Asn Val 
        195                 200                 205             


Ser Leu Leu Gln Ala Thr Glu Trp Ala Ser Ser Glu Asp Thr Arg Arg 
    210                 215                 220                 


Ser Cys Gln Ser Lys Gly Lys Thr Glu Glu Glu Cys Gln Asn Tyr Val 
225                 230                 235                 240 


Arg Val Leu Ile Val Ala Gly Arg Lys Val Phe Met Cys Gly Thr Asn 
                245                 250                 255     


Ala Phe Ser Pro Met Cys Thr Ser Arg Gln Val Gly Asn Leu Ser Arg 
            260                 265                 270         


Thr Ile Glu Lys Ile Asn Gly Val Ala Arg Cys Pro Tyr Asp Pro Arg 
        275                 280                 285             


His Asn Ser Thr Ala Val Ile Ser Ser Gln Gly Glu Leu Tyr Ala Ala 
    290                 295                 300                 


Thr Val Ile Asp Phe Ser Gly Arg Asp Pro Ala Ile Tyr Arg Ser Leu 
305                 310                 315                 320 


Gly Ser Gly Pro Pro Leu Arg Thr Ala Gln Tyr Asn Ser Lys Trp Leu 
                325                 330                 335     


Asn Glu Pro Asn Phe Val Ala Ala Tyr Asp Ile Gly Leu Phe Ala Tyr 
            340                 345                 350         


Phe Phe Leu Arg Glu Asn Ala Val Glu His Asp Cys Gly Arg Thr Val 
        355                 360                 365             


Tyr Ser Arg Val Ala Arg Val Cys Lys Asn Asp Val Gly Gly Arg Phe 
    370                 375                 380                 


Leu Leu Glu Asp Thr Trp Thr Thr Phe Met Lys Ala Arg Leu Asn Cys 
385                 390                 395                 400 


Ser Arg Pro Gly Glu Val Pro Phe Tyr Tyr Asn Glu Leu Gln Ser Ala 
                405                 410                 415     


Phe His Leu Pro Glu Gln Asp Leu Ile Tyr Gly Val Phe Thr Thr Asn 
            420                 425                 430         


Val Asn Ser Ile Ala Ala Ser Ala Val Cys Ala Phe Asn Leu Ser Ala 
        435                 440                 445             


Ile Ser Gln Ala Phe Asn Gly Pro Phe Arg Tyr Gln Glu Asn Pro Arg 
    450                 455                 460                 


Ala Ala Trp Leu Pro Ile Ala Asn Pro Ile Pro Asn Phe Gln Cys Gly 
465                 470                 475                 480 


Thr Leu Pro Glu Thr Gly Pro Asn Glu Asn Leu Thr Glu Arg Ser Leu 
                485                 490                 495     


Gln Asp Ala Gln Arg Leu Phe Leu Met Ser Glu Ala Val Gln Pro Val 
            500                 505                 510         


Thr Pro Glu Pro Cys Val Thr Gln Asp Ser Val Arg Phe Ser His Leu 
        515                 520                 525             


Val Val Asp Leu Val Gln Ala Lys Asp Thr Leu Tyr His Val Leu Tyr 
    530                 535                 540                 


Ile Gly Thr Glu Ser Gly Thr Ile Leu Lys Ala Leu Ser Thr Ala Ser 
545                 550                 555                 560 


Arg Ser Leu His Gly Cys Tyr Leu Glu Glu Leu His Val Leu Pro Pro 
                565                 570                 575     


Gly Arg Arg Glu Pro Leu Arg Ser Leu Arg Ile Leu His Ser Ala Arg 
            580                 585                 590         


Ala Leu Phe Val Gly Leu Arg Asp Gly Val Leu Arg Val Pro Leu Glu 
        595                 600                 605             


Arg Cys Ala Ala Tyr Arg Ser Gln Gly Ala Cys Leu Gly Ala Arg Asp 
    610                 615                 620                 


Pro Tyr Cys Gly Trp Asp Gly Lys Gln Gln Arg Cys Ser Thr Leu Glu 
625                 630                 635                 640 


Asp Ser Ser Asn Met Ser Leu Trp Thr Gln Asn Ile Thr Ala Cys Pro 
                645                 650                 655     


Val Arg Asn Val Thr Arg Asp Gly Gly Phe Gly Pro Trp Ser Pro Trp 
            660                 665                 670         


Gln Pro Cys Glu His Leu Asp Gly Asp Asn Ser Gly Ser Cys Leu Cys 
        675                 680                 685             


Arg Ala Arg Ser Cys Asp Ser Pro Arg Pro Arg Cys Gly Gly Leu Asp 
    690                 695                 700                 


Cys Leu Gly Pro Ala Ile His Ile Ala Asn Cys Ser Arg Asn Gly Ala 
705                 710                 715                 720 


Trp Thr Pro Trp Ser Ser Trp Ala Leu Cys Ser Thr Ser Cys Gly Ile 
                725                 730                 735     


Gly Phe Gln Val Arg Gln Arg Ser Cys Ser Asn Pro Ala Pro Arg His 
            740                 745                 750         


Gly Gly Arg Ile Cys Val Gly Lys Ser Arg Glu Glu Arg Phe Cys Asn 
        755                 760                 765             


Glu Asn Thr Pro Cys Pro Val Pro Ile Phe Trp Ala Ser Trp Gly Ser 
    770                 775                 780                 


Trp Ser Lys Cys Ser Ser Asn Cys Gly Gly Gly Met Gln Ser Arg Arg 
785                 790                 795                 800 


Arg Ala Cys Glu Asn Gly Asn Ser Cys Leu Gly Cys Gly Val Glu Phe 
                805                 810                 815     


Lys Thr Cys Asn Pro Glu Gly Cys Pro Glu Val Arg Arg Asn Thr Pro 
            820                 825                 830         


Trp Thr Pro Trp Leu Pro Val Asn Val Thr Gln Gly Gly Ala Arg Gln 
        835                 840                 845             


Glu Gln Arg Phe Arg Phe Thr Cys Arg Ala Pro Leu Ala Asp Pro His 
    850                 855                 860                 


Gly Leu Gln Phe Gly Arg Arg Arg Thr Glu Thr Arg Thr Cys Pro Ala 
865                 870                 875                 880 


Asp Gly Ser Gly Ser Cys Asp Thr Asp Ala Leu Val Glu Val Leu Leu 
                885                 890                 895     


Arg Ser Gly Ser Thr Ser Pro His Thr Val Ser Gly Gly Trp Ala Ala 
            900                 905                 910         


Trp Gly Pro Trp Ser Ser Cys Ser Arg Asp Cys Glu Leu Gly Phe Arg 
        915                 920                 925             


Val Arg Lys Arg Thr Cys Thr Asn Pro Glu Pro Arg Asn Gly Gly Leu 
    930                 935                 940                 


Pro Cys Val Gly Asp Ala Ala Glu Tyr Gln Asp Cys Asn Pro Gln Ala 
945                 950                 955                 960 


Cys Pro Val Arg Gly Ala Trp Ser Cys Trp Thr Ser Trp Ser Pro Cys 
                965                 970                 975     


Ser Ala Ser Cys Gly Gly Gly His Tyr Gln Arg Thr Arg Ser Cys Thr 
            980                 985                 990         


Ser Pro Ala Pro Ser Pro Gly Glu  Asp Ile Cys Leu Gly  Leu His Thr 
        995                 1000                 1005             


Glu Glu  Ala Leu Cys Ala Thr  Gln Ala Cys Pro Glu  Gly Trp Ser 
    1010                 1015                 1020             


Pro Trp  Ser Glu Trp Ser Lys  Cys Thr Asp Asp Gly  Ala Gln Ser 
    1025                 1030                 1035             


Arg Ser  Arg His Cys Glu Glu  Leu Leu Pro Gly Ser  Ser Ala Cys 
    1040                 1045                 1050             


Ala Gly  Asn Ser Ser Gln Ser  Arg Pro Cys Pro Tyr  Ser Glu Ile 
    1055                 1060                 1065             


Pro Val  Ile Leu Pro Ala Ser  Ser Met Glu Glu Ala  Thr Asp Cys 
    1070                 1075                 1080             


Ala Gly  Phe Asn Leu Ile His  Leu Val Ala Thr Gly  Ile Ser Cys 
    1085                 1090                 1095             


Phe Leu  Gly Ser Gly Leu Leu  Thr Leu Ala Val Tyr  Leu Ser Cys 
    1100                 1105                 1110             


Gln His  Cys Gln Arg Gln Ser  Gln Glu Ser Thr Leu  Val His Pro 
    1115                 1120                 1125             


Ala Thr  Pro Asn His Leu His  Tyr Lys Gly Gly Gly  Thr Pro Lys 
    1130                 1135                 1140             


Asn Glu  Lys Tyr Thr Pro Met  Glu Phe Lys Thr Leu  Asn Lys Asn 
    1145                 1150                 1155             


Asn Leu  Ile Pro Asp Asp Arg  Ala Asn Phe Tyr Pro  Leu Gln Gln 
    1160                 1165                 1170             


Thr Asn  Val Tyr Thr Thr Thr  Tyr Tyr Pro Ser Pro  Leu Asn Lys 
    1175                 1180                 1185             


His Ser  Phe Arg Pro Glu Ala  Ser Pro Gly Gln Arg  Cys Phe Pro 
    1190                 1195                 1200             


Asn Ser  
    1205 


<210>  456
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  456

Met Arg Pro Val Ala Leu Leu Leu Leu Pro Ser Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ala His Gly Leu Ser Leu Glu Ala Pro Thr Val Gly Lys Gly Gln Ala 
            20                  25                  30          


Pro Gly Ile Glu Glu Thr Asp Gly Glu Leu Thr Ala Ala Pro Thr Pro 
        35                  40                  45              


Glu Gln Pro Glu Arg Gly Val His Phe Val Thr Thr Ala Pro Thr Leu 
    50                  55                  60                  


Lys Leu Leu Asn His His Pro Leu Leu Glu Glu Phe Leu Gln Glu Gly 
65                  70                  75                  80  


Leu Glu Lys Gly Asp Glu Glu Leu Arg Pro Ala Leu Pro Phe Gln Pro 
                85                  90                  95      


Asp Pro Pro Ala Pro Phe Thr Pro Ser Pro Leu Pro Arg Leu Ala Asn 
            100                 105                 110         


Gln Asp Ser Arg Pro Val Phe Thr Ser Pro Thr Pro Ala Met Ala Ala 
        115                 120                 125             


Val Pro Thr Gln Pro Gln Ser Lys Glu Gly Pro Trp Ser Pro Glu Ser 
    130                 135                 140                 


Glu Ser Pro Met Leu Arg Ile Thr Ala Pro Leu Pro Pro Gly Pro Ser 
145                 150                 155                 160 


Met Ala Val Pro Thr Leu Gly Pro Gly Glu Ile Ala Ser Thr Thr Pro 
                165                 170                 175     


Pro Ser Arg Ala Trp Thr Pro Thr Gln Glu Gly Pro Gly Asp Met Gly 
            180                 185                 190         


Arg Pro Trp Val Ala Glu Val Val Ser Gln Gly Ala Gly Ile Gly Ile 
        195                 200                 205             


Gln Gly Thr Ile Thr Ser Ser Thr Ala Ser Gly Asp Asp Glu Glu Thr 
    210                 215                 220                 


Thr Thr Thr Thr Thr Ile Ile Thr Thr Thr Ile Thr Thr Val Gln Thr 
225                 230                 235                 240 


Pro Gly Pro Cys Ser Trp Asn Phe Ser Gly Pro Glu Gly Ser Leu Asp 
                245                 250                 255     


Ser Pro Thr Asp Leu Ser Ser Pro Thr Asp Val Gly Leu Asp Cys Phe 
            260                 265                 270         


Phe Tyr Ile Ser Val Tyr Pro Gly Tyr Gly Val Glu Ile Lys Val Gln 
        275                 280                 285             


Asn Ile Ser Leu Arg Glu Gly Glu Thr Val Thr Val Glu Gly Leu Gly 
    290                 295                 300                 


Gly Pro Asp Pro Leu Pro Leu Ala Asn Gln Ser Phe Leu Leu Arg Gly 
305                 310                 315                 320 


Gln Val Ile Arg Ser Pro Thr His Gln Ala Ala Leu Arg Phe Gln Ser 
                325                 330                 335     


Leu Pro Pro Pro Ala Gly Pro Gly Thr Phe His Phe His Tyr Gln Ala 
            340                 345                 350         


Tyr Leu Leu Ser Cys His Phe Pro Arg Arg Pro Ala Tyr Gly Asp Val 
        355                 360                 365             


Thr Val Thr Ser Leu His Pro Gly Gly Ser Ala Arg Phe His Cys Ala 
    370                 375                 380                 


Thr Gly Tyr Gln Leu Lys Gly Ala Arg His Leu Thr Cys Leu Asn Ala 
385                 390                 395                 400 


Thr Gln Pro Phe Trp Asp Ser Lys Glu Pro Val Cys Ile Ala Ala Cys 
                405                 410                 415     


Gly Gly Val Ile Arg Asn Ala Thr Thr Gly Arg Ile Val Ser Pro Gly 
            420                 425                 430         


Phe Pro Gly Asn Tyr Ser Asn Asn Leu Thr Cys His Trp Leu Leu Glu 
        435                 440                 445             


Ala Pro Glu Gly Gln Arg Leu His Leu His Phe Glu Lys Val Ser Leu 
    450                 455                 460                 


Ala Glu Asp Asp Asp Arg Leu Ile Ile Arg Asn Gly Asp Asn Val Glu 
465                 470                 475                 480 


Ala Pro Pro Val Tyr Asp Ser Tyr Glu Val Glu Tyr Leu Pro Ile Glu 
                485                 490                 495     


Gly Leu Leu Ser Ser Gly Lys His Phe Phe Val Glu Leu Ser Thr Asp 
            500                 505                 510         


Ser Ser Gly Ala Ala Ala Gly Met Ala Leu Arg Tyr Glu Ala Phe Gln 
        515                 520                 525             


Gln Gly His Cys Tyr Glu Pro Phe Val Lys Tyr Gly Asn Phe Ser Ser 
    530                 535                 540                 


Ser Thr Pro Thr Tyr Pro Val Gly Thr Thr Val Glu Phe Ser Cys Asp 
545                 550                 555                 560 


Pro Gly Tyr Thr Leu Glu Gln Gly Ser Ile Ile Ile Glu Cys Val Asp 
                565                 570                 575     


Pro His Asp Pro Gln Trp Asn Glu Thr Glu Pro Ala Cys Arg Ala Val 
            580                 585                 590         


Cys Ser Gly Glu Ile Thr Asp Ser Ala Gly Val Val Leu Ser Pro Asn 
        595                 600                 605             


Trp Pro Glu Pro Tyr Gly Arg Gly Gln Asp Cys Ile Trp Gly Val His 
    610                 615                 620                 


Val Glu Glu Asp Lys Arg Ile Met Leu Asp Ile Arg Val Leu Arg Ile 
625                 630                 635                 640 


Gly Pro Gly Asp Val Leu Thr Phe Tyr Asp Gly Asp Asp Leu Thr Ala 
                645                 650                 655     


Arg Val Leu Gly Gln Tyr Ser Gly Pro Arg Ser His Phe Lys Leu Phe 
            660                 665                 670         


Thr Ser Met Ala Asp Val Thr Ile Gln Phe Gln Ser Asp Pro Gly Thr 
        675                 680                 685             


Ser Val Leu Gly Tyr Gln Gln Gly Phe Val Ile His Phe Phe Glu Val 
    690                 695                 700                 


Pro Arg Asn Asp Thr Cys Pro Glu Leu Pro Glu Ile Pro Asn Gly Trp 
705                 710                 715                 720 


Lys Ser Pro Ser Gln Pro Glu Leu Val His Gly Thr Val Val Thr Tyr 
                725                 730                 735     


Gln Cys Tyr Pro Gly Tyr Gln Val Val Gly Ser Ser Val Leu Met Cys 
            740                 745                 750         


Gln Trp Asp Leu Thr Trp Ser Glu Asp Leu Pro Ser Cys Gln Arg Val 
        755                 760                 765             


Thr Ser Cys His Asp Pro Gly Asp Val Glu His Ser Arg Arg Leu Ile 
    770                 775                 780                 


Ser Ser Pro Lys Phe Pro Val Gly Ala Thr Val Gln Tyr Ile Cys Asp 
785                 790                 795                 800 


Gln Gly Phe Val Leu Met Gly Ser Ser Ile Leu Thr Cys His Asp Arg 
                805                 810                 815     


Gln Ala Gly Ser Pro Lys Trp Ser Asp Arg Ala Pro Lys Cys Leu Leu 
            820                 825                 830         


Glu Gln Leu Lys Pro Cys His Gly Leu Ser Ala Pro Glu Asn Gly Ala 
        835                 840                 845             


Arg Ser Pro Glu Lys Gln Leu His Pro Ala Gly Ala Thr Ile His Phe 
    850                 855                 860                 


Ser Cys Ala Pro Gly Tyr Val Leu Lys Gly Gln Ala Ser Ile Lys Cys 
865                 870                 875                 880 


Val Pro Gly His Pro Ser His Trp Ser Asp Pro Pro Pro Ile Cys Arg 
                885                 890                 895     


Ala Ala Ser Leu Asp Gly Phe Tyr Asn Ser Arg Ser Leu Asp Val Ala 
            900                 905                 910         


Lys Ala Pro Ala Ala Ser Ser Thr Leu Asp Ala Ala His Ile Ala Ala 
        915                 920                 925             


Ala Ile Phe Leu Pro Leu Val Ala Met Val Leu Leu Val Gly Gly Val 
    930                 935                 940                 


Tyr Phe Tyr Phe Ser Arg Leu Gln Gly Lys Ser Ser Leu Gln Leu Pro 
945                 950                 955                 960 


Arg Pro Arg Pro Arg Pro Tyr Asn Arg Ile Thr Ile Glu Ser Ala Phe 
                965                 970                 975     


Asp Asn Pro Thr Tyr Glu Thr Gly Glu Thr Arg Glu Tyr Glu Val Ser 
            980                 985                 990         


Ile 
    


<210>  457
<211>  869
<212>  PRT
<213>  Homo sapiens

<400>  457

Met Ala Ala Val Pro Thr Gln Pro Gln Ser Lys Glu Gly Pro Trp Ser 
1               5                   10                  15      


Pro Glu Ser Glu Ser Pro Met Leu Arg Ile Thr Ala Pro Leu Pro Pro 
            20                  25                  30          


Gly Pro Ser Met Ala Val Pro Thr Leu Gly Pro Gly Glu Ile Ala Ser 
        35                  40                  45              


Thr Thr Pro Pro Ser Arg Ala Trp Thr Pro Thr Gln Glu Gly Pro Gly 
    50                  55                  60                  


Asp Met Gly Arg Pro Trp Val Ala Glu Val Val Ser Gln Gly Ala Gly 
65                  70                  75                  80  


Ile Gly Ile Gln Gly Thr Ile Thr Ser Ser Thr Ala Ser Gly Asp Asp 
                85                  90                  95      


Glu Glu Thr Thr Thr Thr Thr Thr Ile Ile Thr Thr Thr Ile Thr Thr 
            100                 105                 110         


Val Gln Thr Pro Gly Pro Cys Ser Trp Asn Phe Ser Gly Pro Glu Gly 
        115                 120                 125             


Ser Leu Asp Ser Pro Thr Asp Leu Ser Ser Pro Thr Asp Val Gly Leu 
    130                 135                 140                 


Asp Cys Phe Phe Tyr Ile Ser Val Tyr Pro Gly Tyr Gly Val Glu Ile 
145                 150                 155                 160 


Lys Val Gln Asn Ile Ser Leu Arg Glu Gly Glu Thr Val Thr Val Glu 
                165                 170                 175     


Gly Leu Gly Gly Pro Asp Pro Leu Pro Leu Ala Asn Gln Ser Phe Leu 
            180                 185                 190         


Leu Arg Gly Gln Val Ile Arg Ser Pro Thr His Gln Ala Ala Leu Arg 
        195                 200                 205             


Phe Gln Ser Leu Pro Pro Pro Ala Gly Pro Gly Thr Phe His Phe His 
    210                 215                 220                 


Tyr Gln Ala Tyr Leu Leu Ser Cys His Phe Pro Arg Arg Pro Ala Tyr 
225                 230                 235                 240 


Gly Asp Val Thr Val Thr Ser Leu His Pro Gly Gly Ser Ala Arg Phe 
                245                 250                 255     


His Cys Ala Thr Gly Tyr Gln Leu Lys Gly Ala Arg His Leu Thr Cys 
            260                 265                 270         


Leu Asn Ala Thr Gln Pro Phe Trp Asp Ser Lys Glu Pro Val Cys Ile 
        275                 280                 285             


Ala Ala Cys Gly Gly Val Ile Arg Asn Ala Thr Thr Gly Arg Ile Val 
    290                 295                 300                 


Ser Pro Gly Phe Pro Gly Asn Tyr Ser Asn Asn Leu Thr Cys His Trp 
305                 310                 315                 320 


Leu Leu Glu Ala Pro Glu Gly Gln Arg Leu His Leu His Phe Glu Lys 
                325                 330                 335     


Val Ser Leu Ala Glu Asp Asp Asp Arg Leu Ile Ile Arg Asn Gly Asp 
            340                 345                 350         


Asn Val Glu Ala Pro Pro Val Tyr Asp Ser Tyr Glu Val Glu Tyr Leu 
        355                 360                 365             


Pro Ile Glu Gly Leu Leu Ser Ser Gly Lys His Phe Phe Val Glu Leu 
    370                 375                 380                 


Ser Thr Asp Ser Ser Gly Ala Ala Ala Gly Met Ala Leu Arg Tyr Glu 
385                 390                 395                 400 


Ala Phe Gln Gln Gly His Cys Tyr Glu Pro Phe Val Lys Tyr Gly Asn 
                405                 410                 415     


Phe Ser Ser Ser Thr Pro Thr Tyr Pro Val Gly Thr Thr Val Glu Phe 
            420                 425                 430         


Ser Cys Asp Pro Gly Tyr Thr Leu Glu Gln Gly Ser Ile Ile Ile Glu 
        435                 440                 445             


Cys Val Asp Pro His Asp Pro Gln Trp Asn Glu Thr Glu Pro Ala Cys 
    450                 455                 460                 


Arg Ala Val Cys Ser Gly Glu Ile Thr Asp Ser Ala Gly Val Val Leu 
465                 470                 475                 480 


Ser Pro Asn Trp Pro Glu Pro Tyr Gly Arg Gly Gln Asp Cys Ile Trp 
                485                 490                 495     


Gly Val His Val Glu Glu Asp Lys Arg Ile Met Leu Asp Ile Arg Val 
            500                 505                 510         


Leu Arg Ile Gly Pro Gly Asp Val Leu Thr Phe Tyr Asp Gly Asp Asp 
        515                 520                 525             


Leu Thr Ala Arg Val Leu Gly Gln Tyr Ser Gly Pro Arg Ser His Phe 
    530                 535                 540                 


Lys Leu Phe Thr Ser Met Ala Asp Val Thr Ile Gln Phe Gln Ser Asp 
545                 550                 555                 560 


Pro Gly Thr Ser Val Leu Gly Tyr Gln Gln Gly Phe Val Ile His Phe 
                565                 570                 575     


Phe Glu Val Pro Arg Asn Asp Thr Cys Pro Glu Leu Pro Glu Ile Pro 
            580                 585                 590         


Asn Gly Trp Lys Ser Pro Ser Gln Pro Glu Leu Val His Gly Thr Val 
        595                 600                 605             


Val Thr Tyr Gln Cys Tyr Pro Gly Tyr Gln Val Val Gly Ser Ser Val 
    610                 615                 620                 


Leu Met Cys Gln Trp Asp Leu Thr Trp Ser Glu Asp Leu Pro Ser Cys 
625                 630                 635                 640 


Gln Arg Val Thr Ser Cys His Asp Pro Gly Asp Val Glu His Ser Arg 
                645                 650                 655     


Arg Leu Ile Ser Ser Pro Lys Phe Pro Val Gly Ala Thr Val Gln Tyr 
            660                 665                 670         


Ile Cys Asp Gln Gly Phe Val Leu Met Gly Ser Ser Ile Leu Thr Cys 
        675                 680                 685             


His Asp Arg Gln Ala Gly Ser Pro Lys Trp Ser Asp Arg Ala Pro Lys 
    690                 695                 700                 


Cys Leu Leu Glu Gln Leu Lys Pro Cys His Gly Leu Ser Ala Pro Glu 
705                 710                 715                 720 


Asn Gly Ala Arg Ser Pro Glu Lys Gln Leu His Pro Ala Gly Ala Thr 
                725                 730                 735     


Ile His Phe Ser Cys Ala Pro Gly Tyr Val Leu Lys Gly Gln Ala Ser 
            740                 745                 750         


Ile Lys Cys Val Pro Gly His Pro Ser His Trp Ser Asp Pro Pro Pro 
        755                 760                 765             


Ile Cys Arg Ala Ala Ser Leu Asp Gly Phe Tyr Asn Ser Arg Ser Leu 
    770                 775                 780                 


Asp Val Ala Lys Ala Pro Ala Ala Ser Ser Thr Leu Asp Ala Ala His 
785                 790                 795                 800 


Ile Ala Ala Ala Ile Phe Leu Pro Leu Val Ala Met Val Leu Leu Val 
                805                 810                 815     


Gly Gly Val Tyr Phe Tyr Phe Ser Arg Leu Gln Gly Lys Ser Ser Leu 
            820                 825                 830         


Gln Leu Pro Arg Pro Arg Pro Arg Pro Tyr Asn Arg Ile Thr Ile Glu 
        835                 840                 845             


Ser Ala Phe Asp Asn Pro Thr Tyr Glu Thr Gly Ser Leu Ser Phe Ala 
    850                 855                 860                 


Gly Asp Glu Arg Ile 
865                 


<210>  458
<211>  994
<212>  PRT
<213>  Homo sapiens

<400>  458

Met Arg Pro Val Ala Leu Leu Leu Leu Pro Ser Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ala His Gly Leu Ser Leu Glu Ala Pro Thr Val Gly Lys Gly Gln Ala 
            20                  25                  30          


Pro Gly Ile Glu Glu Thr Asp Gly Glu Leu Thr Ala Ala Pro Thr Pro 
        35                  40                  45              


Glu Gln Pro Glu Arg Gly Val His Phe Val Thr Thr Ala Pro Thr Leu 
    50                  55                  60                  


Lys Leu Leu Asn His His Pro Leu Leu Glu Glu Phe Leu Gln Glu Gly 
65                  70                  75                  80  


Leu Glu Lys Gly Asp Glu Glu Leu Arg Pro Ala Leu Pro Phe Gln Pro 
                85                  90                  95      


Asp Pro Pro Ala Pro Phe Thr Pro Ser Pro Leu Pro Arg Leu Ala Asn 
            100                 105                 110         


Gln Asp Ser Arg Pro Val Phe Thr Ser Pro Thr Pro Ala Met Ala Ala 
        115                 120                 125             


Val Pro Thr Gln Pro Gln Ser Lys Glu Gly Pro Trp Ser Pro Glu Ser 
    130                 135                 140                 


Glu Ser Pro Met Leu Arg Ile Thr Ala Pro Leu Pro Pro Gly Pro Ser 
145                 150                 155                 160 


Met Ala Val Pro Thr Leu Gly Pro Gly Glu Ile Ala Ser Thr Thr Pro 
                165                 170                 175     


Pro Ser Arg Ala Trp Thr Pro Thr Gln Glu Gly Pro Gly Asp Met Gly 
            180                 185                 190         


Arg Pro Trp Val Ala Glu Val Val Ser Gln Gly Ala Gly Ile Gly Ile 
        195                 200                 205             


Gln Gly Thr Ile Thr Ser Ser Thr Ala Ser Gly Asp Asp Glu Glu Thr 
    210                 215                 220                 


Thr Thr Thr Thr Thr Ile Ile Thr Thr Thr Ile Thr Thr Val Gln Thr 
225                 230                 235                 240 


Pro Gly Pro Cys Ser Trp Asn Phe Ser Gly Pro Glu Gly Ser Leu Asp 
                245                 250                 255     


Ser Pro Thr Asp Leu Ser Ser Pro Thr Asp Val Gly Leu Asp Cys Phe 
            260                 265                 270         


Phe Tyr Ile Ser Val Tyr Pro Gly Tyr Gly Val Glu Ile Lys Val Gln 
        275                 280                 285             


Asn Ile Ser Leu Arg Glu Gly Glu Thr Val Thr Val Glu Gly Leu Gly 
    290                 295                 300                 


Gly Pro Asp Pro Leu Pro Leu Ala Asn Gln Ser Phe Leu Leu Arg Gly 
305                 310                 315                 320 


Gln Val Ile Arg Ser Pro Thr His Gln Ala Ala Leu Arg Phe Gln Ser 
                325                 330                 335     


Leu Pro Pro Pro Ala Gly Pro Gly Thr Phe His Phe His Tyr Gln Ala 
            340                 345                 350         


Tyr Leu Leu Ser Cys His Phe Pro Arg Arg Pro Ala Tyr Gly Asp Val 
        355                 360                 365             


Thr Val Thr Ser Leu His Pro Gly Gly Ser Ala Arg Phe His Cys Ala 
    370                 375                 380                 


Thr Gly Tyr Gln Leu Lys Gly Ala Arg His Leu Thr Cys Leu Asn Ala 
385                 390                 395                 400 


Thr Gln Pro Phe Trp Asp Ser Lys Glu Pro Val Cys Ile Ala Ala Cys 
                405                 410                 415     


Gly Gly Val Ile Arg Asn Ala Thr Thr Gly Arg Ile Val Ser Pro Gly 
            420                 425                 430         


Phe Pro Gly Asn Tyr Ser Asn Asn Leu Thr Cys His Trp Leu Leu Glu 
        435                 440                 445             


Ala Pro Glu Gly Gln Arg Leu His Leu His Phe Glu Lys Val Ser Leu 
    450                 455                 460                 


Ala Glu Asp Asp Asp Arg Leu Ile Ile Arg Asn Gly Asp Asn Val Glu 
465                 470                 475                 480 


Ala Pro Pro Val Tyr Asp Ser Tyr Glu Val Glu Tyr Leu Pro Ile Glu 
                485                 490                 495     


Gly Leu Leu Ser Ser Gly Lys His Phe Phe Val Glu Leu Ser Thr Asp 
            500                 505                 510         


Ser Ser Gly Ala Ala Ala Gly Met Ala Leu Arg Tyr Glu Ala Phe Gln 
        515                 520                 525             


Gln Gly His Cys Tyr Glu Pro Phe Val Lys Tyr Gly Asn Phe Ser Ser 
    530                 535                 540                 


Ser Thr Pro Thr Tyr Pro Val Gly Thr Thr Val Glu Phe Ser Cys Asp 
545                 550                 555                 560 


Pro Gly Tyr Thr Leu Glu Gln Gly Ser Ile Ile Ile Glu Cys Val Asp 
                565                 570                 575     


Pro His Asp Pro Gln Trp Asn Glu Thr Glu Pro Ala Cys Arg Ala Val 
            580                 585                 590         


Cys Ser Gly Glu Ile Thr Asp Ser Ala Gly Val Val Leu Ser Pro Asn 
        595                 600                 605             


Trp Pro Glu Pro Tyr Gly Arg Gly Gln Asp Cys Ile Trp Gly Val His 
    610                 615                 620                 


Val Glu Glu Asp Lys Arg Ile Met Leu Asp Ile Arg Val Leu Arg Ile 
625                 630                 635                 640 


Gly Pro Gly Asp Val Leu Thr Phe Tyr Asp Gly Asp Asp Leu Thr Ala 
                645                 650                 655     


Arg Val Leu Gly Gln Tyr Ser Gly Pro Arg Ser His Phe Lys Leu Phe 
            660                 665                 670         


Thr Ser Met Ala Asp Val Thr Ile Gln Phe Gln Ser Asp Pro Gly Thr 
        675                 680                 685             


Ser Val Leu Gly Tyr Gln Gln Gly Phe Val Ile His Phe Phe Glu Val 
    690                 695                 700                 


Pro Arg Asn Asp Thr Cys Pro Glu Leu Pro Glu Ile Pro Asn Gly Trp 
705                 710                 715                 720 


Lys Ser Pro Ser Gln Pro Glu Leu Val His Gly Thr Val Val Thr Tyr 
                725                 730                 735     


Gln Cys Tyr Pro Gly Tyr Gln Val Val Gly Ser Ser Val Leu Met Cys 
            740                 745                 750         


Gln Trp Asp Leu Thr Trp Ser Glu Asp Leu Pro Ser Cys Gln Arg Val 
        755                 760                 765             


Thr Ser Cys His Asp Pro Gly Asp Val Glu His Ser Arg Arg Leu Ile 
    770                 775                 780                 


Ser Ser Pro Lys Phe Pro Val Gly Ala Thr Val Gln Tyr Ile Cys Asp 
785                 790                 795                 800 


Gln Gly Phe Val Leu Met Gly Ser Ser Ile Leu Thr Cys His Asp Arg 
                805                 810                 815     


Gln Ala Gly Ser Pro Lys Trp Ser Asp Arg Ala Pro Lys Cys Leu Leu 
            820                 825                 830         


Glu Gln Leu Lys Pro Cys His Gly Leu Ser Ala Pro Glu Asn Gly Ala 
        835                 840                 845             


Arg Ser Pro Glu Lys Gln Leu His Pro Ala Gly Ala Thr Ile His Phe 
    850                 855                 860                 


Ser Cys Ala Pro Gly Tyr Val Leu Lys Gly Gln Ala Ser Ile Lys Cys 
865                 870                 875                 880 


Val Pro Gly His Pro Ser His Trp Ser Asp Pro Pro Pro Ile Cys Arg 
                885                 890                 895     


Ala Ala Ser Leu Asp Gly Phe Tyr Asn Ser Arg Ser Leu Asp Val Ala 
            900                 905                 910         


Lys Ala Pro Ala Ala Ser Ser Thr Leu Asp Ala Ala His Ile Ala Ala 
        915                 920                 925             


Ala Ile Phe Leu Pro Leu Val Ala Met Val Leu Leu Val Gly Gly Val 
    930                 935                 940                 


Tyr Phe Tyr Phe Ser Arg Leu Gln Gly Lys Ser Ser Leu Gln Leu Pro 
945                 950                 955                 960 


Arg Pro Arg Pro Arg Pro Tyr Asn Arg Ile Thr Ile Glu Ser Ala Phe 
                965                 970                 975     


Asp Asn Pro Thr Tyr Glu Thr Gly Ser Leu Ser Phe Ala Gly Asp Glu 
            980                 985                 990         


Arg Ile 
        


<210>  459
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  459

Met Gly Leu Leu Gln Gly Leu Leu Arg Val Arg Lys Leu Leu Leu Val 
1               5                   10                  15      


Val Cys Val Pro Leu Leu Leu Leu Pro Leu Pro Val Leu His Pro Ser 
            20                  25                  30          


Ser Glu Ala Ser Cys Ala Tyr Val Leu Ile Val Thr Ala Val Tyr Trp 
        35                  40                  45              


Val Ser Glu Ala Val Pro Leu Gly Ala Ala Ala Leu Val Pro Ala Phe 
    50                  55                  60                  


Leu Tyr Pro Phe Phe Gly Val Leu Arg Ser Asn Glu Val Ala Ala Glu 
65                  70                  75                  80  


Tyr Phe Lys Asn Thr Thr Leu Leu Leu Val Gly Val Ile Cys Val Ala 
                85                  90                  95      


Ala Ala Val Glu Lys Trp Asn Leu His Lys Arg Ile Ala Leu Arg Met 
            100                 105                 110         


Val Leu Met Ala Gly Ala Lys Pro Gly Met Leu Leu Leu Cys Phe Met 
        115                 120                 125             


Cys Cys Thr Thr Leu Leu Ser Met Trp Leu Ser Asn Thr Ser Thr Thr 
    130                 135                 140                 


Ala Met Val Met Pro Ile Val Glu Ala Val Leu Gln Glu Leu Val Ser 
145                 150                 155                 160 


Ala Glu Asp Glu Gln Leu Val Ala Gly Asn Ser Asn Thr Glu Glu Ala 
                165                 170                 175     


Glu Pro Ile Ser Leu Asp Val Lys Asn Ser Gln Pro Ser Leu Glu Leu 
            180                 185                 190         


Ile Phe Val Asn Glu Asp Arg Ser Asn Ala Asp Leu Thr Thr Leu Met 
        195                 200                 205             


His Asn Glu Asn Leu Asn Gly Val Pro Ser Ile Thr Asn Pro Ile Lys 
    210                 215                 220                 


Thr Ala Asn Gln His Gln Gly Lys Lys Gln His Pro Ser Gln Glu Lys 
225                 230                 235                 240 


Pro Gln Val Leu Thr Pro Ser Pro Arg Lys Gln Lys Leu Asn Arg Lys 
                245                 250                 255     


Tyr Arg Ser His His Asp Gln Met Ile Cys Lys Cys Leu Ser Leu Ser 
            260                 265                 270         


Ile Ser Tyr Ser Ala Thr Ile Gly Gly Leu Thr Thr Ile Ile Gly Thr 
        275                 280                 285             


Ser Thr Ser Leu Ile Phe Leu Glu His Phe Asn Asn Gln Tyr Pro Ala 
    290                 295                 300                 


Ala Glu Val Val Asn Phe Gly Thr Trp Phe Leu Phe Ser Phe Pro Ile 
305                 310                 315                 320 


Ser Leu Ile Met Leu Val Val Ser Trp Phe Trp Met His Trp Leu Phe 
                325                 330                 335     


Leu Gly Cys Asn Phe Lys Glu Thr Cys Ser Leu Ser Lys Lys Lys Lys 
            340                 345                 350         


Thr Lys Arg Glu Gln Leu Ser Glu Lys Arg Ile Gln Glu Glu Tyr Glu 
        355                 360                 365             


Lys Leu Gly Asp Ile Ser Tyr Pro Glu Met Val Thr Gly Phe Phe Phe 
    370                 375                 380                 


Ile Leu Met Thr Val Leu Trp Phe Thr Arg Glu Pro Gly Phe Val Pro 
385                 390                 395                 400 


Gly Trp Asp Ser Phe Phe Glu Lys Lys Gly Tyr Arg Thr Asp Ala Thr 
                405                 410                 415     


Val Ser Val Phe Leu Gly Phe Leu Leu Phe Leu Ile Pro Ala Lys Lys 
            420                 425                 430         


Pro Cys Phe Gly Lys Lys Asn Asp Gly Glu Asn Gln Glu His Ser Leu 
        435                 440                 445             


Gly Thr Glu Pro Ile Ile Thr Trp Lys Asp Phe Gln Lys Thr Met Pro 
    450                 455                 460                 


Trp Glu Ile Val Ile Leu Val Gly Gly Gly Tyr Ala Leu Ala Ser Gly 
465                 470                 475                 480 


Ser Lys Ser Ser Gly Leu Ser Thr Trp Ile Gly Asn Gln Met Leu Ser 
                485                 490                 495     


Leu Ser Ser Leu Pro Pro Trp Ala Val Thr Leu Leu Ala Cys Ile Leu 
            500                 505                 510         


Val Ser Ile Val Thr Glu Phe Val Ser Asn Pro Ala Thr Ile Thr Ile 
        515                 520                 525             


Phe Leu Pro Ile Leu Cys Ser Leu Ser Glu Thr Leu His Ile Asn Pro 
    530                 535                 540                 


Leu Tyr Thr Leu Ile Pro Val Thr Met Cys Ile Ser Phe Ala Val Met 
545                 550                 555                 560 


Leu Pro Val Gly Asn Pro Pro Asn Ala Ile Val Phe Ser Tyr Gly His 
                565                 570                 575     


Cys Gln Ile Lys Asp Met Val Lys Ala Gly Leu Gly Val Asn Val Ile 
            580                 585                 590         


Gly Leu Val Ile Val Met Val Ala Ile Asn Thr Trp Gly Val Ser Leu 
        595                 600                 605             


Phe His Leu Asp Thr Tyr Pro Ala Trp Ala Arg Val Ser Asn Ile Thr 
    610                 615                 620                 


Asp Gln Ala 
625         


<210>  460
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  460

Met Gly Leu Leu Gln Gly Leu Leu Arg Val Arg Lys Leu Leu Leu Val 
1               5                   10                  15      


Val Cys Val Pro Leu Leu Leu Leu Pro Leu Pro Val Leu His Pro Ser 
            20                  25                  30          


Ser Glu Ala Ser Cys Ala Tyr Val Leu Ile Val Thr Ala Val Tyr Trp 
        35                  40                  45              


Val Ser Glu Ala Val Pro Leu Gly Ala Ala Ala Leu Val Pro Ala Phe 
    50                  55                  60                  


Leu Tyr Pro Phe Phe Gly Val Leu Arg Ser Asn Glu Val Ala Ala Glu 
65                  70                  75                  80  


Tyr Phe Lys Asn Thr Thr Leu Leu Leu Val Gly Val Ile Cys Val Ala 
                85                  90                  95      


Ala Ala Val Glu Lys Trp Asn Leu His Lys Arg Ile Ala Leu Arg Met 
            100                 105                 110         


Val Leu Met Ala Gly Ala Lys Pro Gly Met Leu Leu Leu Cys Phe Met 
        115                 120                 125             


Cys Cys Thr Thr Leu Leu Ser Met Trp Leu Ser Asn Thr Ser Thr Thr 
    130                 135                 140                 


Ala Met Val Met Pro Ile Val Glu Ala Val Leu Gln Glu Leu Val Ser 
145                 150                 155                 160 


Ala Glu Asp Glu Gln Leu Val Ala Gly Asn Ser Asn Thr Glu Glu Ala 
                165                 170                 175     


Glu Pro Ile Ser Leu Asp Val Lys Asn Ser Gln Pro Ser Leu Glu Leu 
            180                 185                 190         


Ile Phe Val Asn Glu Glu Ser Asn Ala Asp Leu Thr Thr Leu Met His 
        195                 200                 205             


Asn Glu Asn Leu Asn Gly Val Pro Ser Ile Thr Asn Pro Ile Lys Thr 
    210                 215                 220                 


Ala Asn Gln His Gln Gly Lys Lys Gln His Pro Ser Gln Glu Lys Pro 
225                 230                 235                 240 


Gln Val Leu Thr Pro Ser Pro Arg Lys Gln Lys Leu Asn Arg Lys Tyr 
                245                 250                 255     


Arg Ser His His Asp Gln Met Ile Cys Lys Cys Leu Ser Leu Ser Ile 
            260                 265                 270         


Ser Tyr Ser Ala Thr Ile Gly Gly Leu Thr Thr Ile Ile Gly Thr Ser 
        275                 280                 285             


Thr Ser Leu Ile Phe Leu Glu His Phe Asn Asn Gln Tyr Pro Ala Ala 
    290                 295                 300                 


Glu Val Val Asn Phe Gly Thr Trp Phe Leu Phe Ser Phe Pro Ile Ser 
305                 310                 315                 320 


Leu Ile Met Leu Val Val Ser Trp Phe Trp Met His Trp Leu Phe Leu 
                325                 330                 335     


Gly Cys Asn Phe Lys Glu Thr Cys Ser Leu Ser Lys Lys Lys Lys Thr 
            340                 345                 350         


Lys Arg Glu Gln Leu Ser Glu Lys Arg Ile Gln Glu Glu Tyr Glu Lys 
        355                 360                 365             


Leu Gly Asp Ile Ser Tyr Pro Glu Met Val Thr Gly Phe Phe Phe Ile 
    370                 375                 380                 


Leu Met Thr Val Leu Trp Phe Thr Arg Glu Pro Gly Phe Val Pro Gly 
385                 390                 395                 400 


Trp Asp Ser Phe Phe Glu Lys Lys Gly Tyr Arg Thr Asp Ala Thr Val 
                405                 410                 415     


Ser Val Phe Leu Gly Phe Leu Leu Phe Leu Ile Pro Ala Lys Lys Pro 
            420                 425                 430         


Cys Phe Gly Lys Lys Asn Asp Gly Glu Asn Gln Glu His Ser Leu Gly 
        435                 440                 445             


Thr Glu Pro Ile Ile Thr Trp Lys Asp Phe Gln Lys Thr Met Pro Trp 
    450                 455                 460                 


Glu Ile Val Ile Leu Val Gly Gly Gly Tyr Ala Leu Ala Ser Gly Ser 
465                 470                 475                 480 


Lys Ser Ser Gly Leu Ser Thr Trp Ile Gly Asn Gln Met Leu Ser Leu 
                485                 490                 495     


Ser Ser Leu Pro Pro Trp Ala Val Thr Leu Leu Ala Cys Ile Leu Val 
            500                 505                 510         


Ser Ile Val Thr Glu Phe Val Ser Asn Pro Ala Thr Ile Thr Ile Phe 
        515                 520                 525             


Leu Pro Ile Leu Cys Ser Leu Ser Glu Thr Leu His Ile Asn Pro Leu 
    530                 535                 540                 


Tyr Thr Leu Ile Pro Val Thr Met Cys Ile Ser Phe Ala Val Met Leu 
545                 550                 555                 560 


Pro Val Gly Asn Pro Pro Asn Ala Ile Val Phe Ser Tyr Gly His Cys 
                565                 570                 575     


Gln Ile Lys Asp Met Val Lys Ala Gly Leu Gly Val Asn Val Ile Gly 
            580                 585                 590         


Leu Val Ile Val Met Val Ala Ile Asn Thr Trp Gly Val Ser Leu Phe 
        595                 600                 605             


His Leu Asp Thr Tyr Pro Ala Trp Ala Arg Val Ser Asn Ile Thr Asp 
    610                 615                 620                 


Gln Ala 
625     


<210>  461
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  461

Met Leu Lys Arg Glu Gly Lys Val Gln Pro Tyr Thr Lys Thr Leu Asp 
1               5                   10                  15      


Gly Gly Trp Gly Trp Met Ile Val Ile His Phe Phe Leu Val Asn Val 
            20                  25                  30          


Phe Val Met Gly Met Thr Lys Thr Phe Ala Ile Phe Phe Val Val Phe 
        35                  40                  45              


Gln Glu Glu Phe Glu Gly Thr Ser Glu Gln Ile Gly Trp Ile Gly Ser 
    50                  55                  60                  


Ile Met Ser Ser Leu Arg Phe Cys Ala Gly Leu Gly Ser Ala Phe Leu 
65                  70                  75                  80  


Tyr Gln Val Ala Ala Val Val Thr Thr Lys Tyr Phe Lys Lys Arg Leu 
                85                  90                  95      


Ala Leu Ser Thr Ala Ile Ala Arg Ser Gly Met Gly Leu Thr Phe Leu 
            100                 105                 110         


Leu Ala Pro Phe Thr Lys Phe Leu Ile Asp Leu Tyr Asp Trp Thr Gly 
        115                 120                 125             


Ala Leu Ile Leu Phe Gly Ala Ile Ala Leu Asn Leu Val Pro Ser Ser 
    130                 135                 140                 


Met Leu Leu Arg Pro Ile His Ile Lys Ser Glu Asn Asn Ser Gly Ile 
145                 150                 155                 160 


Lys Asp Lys Gly Ser Ser Leu Ser Ala His Gly Pro Glu Ala His Ala 
                165                 170                 175     


Thr Glu Thr His Cys His Glu Thr Glu Glu Ser Thr Ile Lys Asp Ser 
            180                 185                 190         


Thr Thr Gln Lys Ala Gly Leu Pro Ser Lys Asn Leu Thr Val Ser Gln 
        195                 200                 205             


Asn Gln Ser Glu Glu Phe Tyr Asn Gly Pro Asn Arg Asn Arg Leu Leu 
    210                 215                 220                 


Leu Lys Ser Asp Glu Glu Ser Asp Lys Val Ile Ser Trp Ser Cys Lys 
225                 230                 235                 240 


Gln Leu Phe Asp Ile Ser Leu Phe Arg Asn Pro Phe Phe Tyr Ile Phe 
                245                 250                 255     


Thr Trp Ser Phe Leu Leu Ser Gln Leu Ala Tyr Phe Ile Pro Thr Phe 
            260                 265                 270         


His Leu Val Ala Arg Ala Lys Thr Leu Gly Ile Asp Ile Met Asp Ala 
        275                 280                 285             


Ser Tyr Leu Val Ser Val Ala Gly Ile Leu Glu Thr Val Ser Gln Ile 
    290                 295                 300                 


Ile Ser Gly Trp Val Ala Asp Gln Asn Trp Ile Lys Lys Tyr His Tyr 
305                 310                 315                 320 


His Lys Ser Tyr Leu Ile Leu Cys Gly Ile Thr Asn Leu Leu Ala Pro 
                325                 330                 335     


Leu Ala Thr Thr Phe Pro Leu Leu Met Thr Tyr Thr Ile Cys Phe Ala 
            340                 345                 350         


Ile Phe Ala Gly Gly Tyr Leu Ala Leu Ile Leu Pro Val Leu Val Asp 
        355                 360                 365             


Leu Cys Arg Asn Ser Thr Val Asn Arg Phe Leu Gly Leu Ala Ser Phe 
    370                 375                 380                 


Phe Ala Gly Met Ala Val Leu Ser Gly Pro Pro Ile Ala Gly Trp Leu 
385                 390                 395                 400 


Tyr Asp Tyr Thr Gln Thr Tyr Asn Gly Ser Phe Tyr Phe Ser Gly Ile 
                405                 410                 415     


Cys Tyr Leu Leu Ser Ser Val Ser Phe Phe Phe Val Pro Leu Ala Glu 
            420                 425                 430         


Arg Trp Lys Asn Ser Leu Thr 
        435                 


<210>  462
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  462

Met Gly Met Asp Asp Cys Asp Ser Phe Phe Pro Gly Pro Leu Val Ala 
1               5                   10                  15      


Ile Ile Cys Asp Ile Leu Gly Glu Lys Thr Thr Ser Ile Leu Gly Ala 
            20                  25                  30          


Phe Val Val Thr Gly Gly Tyr Leu Ile Ser Ser Trp Ala Thr Ser Ile 
        35                  40                  45              


Pro Phe Leu Cys Val Thr Met Gly Leu Leu Pro Gly Leu Gly Ser Ala 
    50                  55                  60                  


Phe Leu Tyr Gln Val Ala Ala Val Val Thr Thr Lys Tyr Phe Lys Lys 
65                  70                  75                  80  


Arg Leu Ala Leu Ser Thr Ala Ile Ala Arg Ser Gly Met Gly Leu Thr 
                85                  90                  95      


Phe Leu Leu Ala Pro Phe Thr Lys Phe Leu Ile Asp Leu Tyr Asp Trp 
            100                 105                 110         


Thr Gly Ala Leu Ile Leu Phe Gly Ala Ile Ala Leu Asn Leu Val Pro 
        115                 120                 125             


Ser Ser Met Leu Leu Arg Pro Ile His Ile Lys Ser Glu Asn Asn Ser 
    130                 135                 140                 


Gly Ile Lys Asp Lys Gly Ser Ser Leu Ser Ala His Gly Pro Glu Ala 
145                 150                 155                 160 


His Ala Thr Glu Thr His Cys His Glu Thr Glu Glu Ser Thr Ile Lys 
                165                 170                 175     


Asp Ser Thr Thr Gln Lys Ala Gly Leu Pro Ser Lys Asn Leu Thr Val 
            180                 185                 190         


Ser Gln Asn Gln Ser Glu Glu Phe Tyr Asn Gly Pro Asn Arg Asn Arg 
        195                 200                 205             


Leu Leu Leu Lys Ser Asp Glu Glu Ser Asp Lys Val Ile Ser Trp Ser 
    210                 215                 220                 


Cys Lys Gln Leu Phe Asp Ile Ser Leu Phe Arg Asn Pro Phe Phe Tyr 
225                 230                 235                 240 


Ile Phe Thr Trp Ser Phe Leu Leu Ser Gln Leu Ala Tyr Phe Ile Pro 
                245                 250                 255     


Thr Phe His Leu Val Ala Arg Ala Lys Thr Leu Gly Ile Asp Ile Met 
            260                 265                 270         


Asp Ala Ser Tyr Leu Val Ser Val Ala Gly Ile Leu Glu Thr Val Ser 
        275                 280                 285             


Gln Ile Ile Ser Gly Trp Val Ala Asp Gln Asn Trp Ile Lys Lys Tyr 
    290                 295                 300                 


His Tyr His Lys Ser Tyr Leu Ile Leu Cys Gly Ile Thr Asn Leu Leu 
305                 310                 315                 320 


Ala Pro Leu Ala Thr Thr Phe Pro Leu Leu Met Thr Tyr Thr Ile Cys 
                325                 330                 335     


Phe Ala Ile Phe Ala Gly Gly Tyr Leu Ala Leu Ile Leu Pro Val Leu 
            340                 345                 350         


Val Asp Leu Cys Arg Asn Ser Thr Val Asn Arg Phe Leu Gly Leu Ala 
        355                 360                 365             


Ser Phe Phe Ala Gly Met Ala Val Leu Ser Gly Pro Pro Ile Ala Gly 
    370                 375                 380                 


Trp Leu Tyr Asp Tyr Thr Gln Thr Tyr Asn Gly Ser Phe Tyr Phe Ser 
385                 390                 395                 400 


Gly Ile Cys Tyr Leu Leu Ser Ser Val Ser Phe Phe Phe Val Pro Leu 
                405                 410                 415     


Ala Glu Arg Trp Lys Asn Ser Leu Thr 
            420                 425 


<210>  463
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  463

Met Gly Met Asp Asp Cys Asp Ser Phe Phe Pro Gly Leu Gly Ser Ala 
1               5                   10                  15      


Phe Leu Tyr Gln Val Ala Ala Val Val Thr Thr Lys Tyr Phe Lys Lys 
            20                  25                  30          


Arg Leu Ala Leu Ser Thr Ala Ile Ala Arg Ser Gly Met Gly Leu Thr 
        35                  40                  45              


Phe Leu Leu Ala Pro Phe Thr Lys Phe Leu Ile Asp Leu Tyr Asp Trp 
    50                  55                  60                  


Thr Gly Ala Leu Ile Leu Phe Gly Ala Ile Ala Leu Asn Leu Val Pro 
65                  70                  75                  80  


Ser Ser Met Leu Leu Arg Pro Ile His Ile Lys Ser Glu Asn Asn Ser 
                85                  90                  95      


Gly Ile Lys Asp Lys Gly Ser Ser Leu Ser Ala His Gly Pro Glu Ala 
            100                 105                 110         


His Ala Thr Glu Thr His Cys His Glu Thr Glu Glu Ser Thr Ile Lys 
        115                 120                 125             


Asp Ser Thr Thr Gln Lys Ala Gly Leu Pro Ser Lys Asn Leu Thr Val 
    130                 135                 140                 


Ser Gln Asn Gln Ser Glu Glu Phe Tyr Asn Gly Pro Asn Arg Asn Arg 
145                 150                 155                 160 


Leu Leu Leu Lys Ser Asp Glu Glu Ser Asp Lys Val Ile Ser Trp Ser 
                165                 170                 175     


Cys Lys Gln Leu Phe Asp Ile Ser Leu Phe Arg Asn Pro Phe Phe Tyr 
            180                 185                 190         


Ile Phe Thr Trp Ser Phe Leu Leu Ser Gln Leu Ala Tyr Phe Ile Pro 
        195                 200                 205             


Thr Phe His Leu Val Ala Arg Ala Lys Thr Leu Gly Ile Asp Ile Met 
    210                 215                 220                 


Asp Ala Ser Tyr Leu Val Ser Val Ala Gly Ile Leu Glu Thr Val Ser 
225                 230                 235                 240 


Gln Ile Ile Ser Gly Trp Val Ala Asp Gln Asn Trp Ile Lys Lys Tyr 
                245                 250                 255     


His Tyr His Lys Ser Tyr Leu Ile Leu Cys Gly Ile Thr Asn Leu Leu 
            260                 265                 270         


Ala Pro Leu Ala Thr Thr Phe Pro Leu Leu Met Thr Tyr Thr Ile Cys 
        275                 280                 285             


Phe Ala Ile Phe Ala Gly Gly Tyr Leu Ala Leu Ile Leu Pro Val Leu 
    290                 295                 300                 


Val Asp Leu Cys Arg Asn Ser Thr Val Asn Arg Phe Leu Gly Leu Ala 
305                 310                 315                 320 


Ser Phe Phe Ala Gly Met Ala Val Leu Ser Gly Pro Pro Ile Ala Glu 
                325                 330                 335     


Ile Ile Pro Ser Phe Gln Ala Gly Tyr Met Ile Ile Pro Arg His Thr 
            340                 345                 350         


Met Ala Leu Ser Thr Ser Leu Ala Tyr Ala Ile Ser Ser Leu Gln Phe 
        355                 360                 365             


Pro Phe Phe Leu Tyr His Trp Pro Lys Asp Gly Lys Thr Val 
    370                 375                 380         


<210>  464
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  464

Met Leu Lys Arg Glu Gly Lys Val Gln Pro Tyr Thr Lys Thr Leu Asp 
1               5                   10                  15      


Gly Gly Trp Gly Trp Met Ile Val Ile His Phe Phe Leu Val Asn Val 
            20                  25                  30          


Phe Val Met Gly Met Thr Lys Thr Phe Ala Ile Phe Phe Val Val Phe 
        35                  40                  45              


Gln Glu Glu Phe Glu Gly Thr Ser Glu Gln Ile Gly Trp Ile Gly Ser 
    50                  55                  60                  


Ile Met Ser Ser Leu Arg Phe Cys Ala Gly Pro Leu Val Ala Ile Ile 
65                  70                  75                  80  


Cys Asp Ile Leu Gly Glu Lys Thr Thr Ser Ile Leu Gly Ala Phe Val 
                85                  90                  95      


Val Thr Gly Gly Tyr Leu Ile Ser Ser Trp Ala Thr Ser Ile Pro Phe 
            100                 105                 110         


Leu Cys Val Thr Met Gly Leu Leu Pro Gly Leu Gly Ser Ala Phe Leu 
        115                 120                 125             


Tyr Gln Val Ala Ala Val Val Thr Thr Lys Tyr Phe Lys Lys Arg Leu 
    130                 135                 140                 


Ala Leu Ser Thr Ala Ile Ala Arg Ser Gly Met Gly Leu Thr Phe Leu 
145                 150                 155                 160 


Leu Ala Pro Phe Thr Lys Phe Leu Ile Asp Leu Tyr Asp Trp Thr Gly 
                165                 170                 175     


Ile Leu Glu Thr Val Ser Gln Ile Ile Ser Gly Trp Val Ala Asp Gln 
            180                 185                 190         


Asn Trp Ile Lys Lys Tyr His Tyr His Lys Ser Tyr Leu Ile Leu Cys 
        195                 200                 205             


Gly Ile Thr Asn Leu Leu Ala Pro Leu Ala Thr Thr Phe Pro Leu Leu 
    210                 215                 220                 


Met Thr Tyr Thr Ile Cys Phe Ala Ile Phe Ala Gly Gly Tyr Leu Ala 
225                 230                 235                 240 


Leu Ile Leu Pro Val Leu Val Asp Leu Cys Arg Asn Ser Thr Val Asn 
                245                 250                 255     


Arg Phe Leu Gly Leu Ala Ser Phe Phe Ala Gly Met Ala Val Leu Ser 
            260                 265                 270         


Gly Pro Pro Ile Ala Gly Trp Leu Tyr Asp Tyr Thr Gln Thr Tyr Asn 
        275                 280                 285             


Gly Ser Phe Tyr Phe Ser Gly Ile Cys Tyr Leu Leu Ser Ser Val Ser 
    290                 295                 300                 


Phe Phe Phe Val Pro Leu Ala Glu Arg Trp Lys Asn Ser Leu Thr 
305                 310                 315                 


<210>  465
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  465

Met Leu Lys Arg Glu Gly Lys Val Gln Pro Tyr Thr Lys Thr Leu Asp 
1               5                   10                  15      


Gly Gly Trp Gly Trp Met Ile Val Ile His Phe Phe Leu Val Asn Val 
            20                  25                  30          


Phe Val Met Gly Met Thr Lys Thr Phe Ala Ile Phe Phe Val Val Phe 
        35                  40                  45              


Gln Glu Glu Phe Glu Gly Thr Ser Glu Gln Ile Gly Trp Ile Gly Ser 
    50                  55                  60                  


Ile Met Ser Ser Leu Arg Phe Cys Ala Gly Pro Leu Val Ala Ile Ile 
65                  70                  75                  80  


Cys Asp Ile Leu Gly Glu Lys Thr Thr Ser Ile Leu Gly Ala Phe Val 
                85                  90                  95      


Val Thr Gly Gly Tyr Leu Ile Ser Ser Trp Ala Thr Ser Ile Pro Phe 
            100                 105                 110         


Leu Cys Val Thr Met Gly Leu Leu Pro Gly Leu Gly Ser Ala Phe Leu 
        115                 120                 125             


Tyr Gln Val Ala Ala Val Val Thr Thr Lys Tyr Phe Lys Lys Arg Leu 
    130                 135                 140                 


Ala Leu Ser Thr Ala Ile Ala Arg Ser Gly Met Gly Leu Thr Phe Leu 
145                 150                 155                 160 


Leu Ala Pro Phe Thr Lys Phe Leu Ile Asp Leu Tyr Asp Trp Thr Gly 
                165                 170                 175     


Ala Leu Ile Leu Phe Gly Ala Ile Ala Leu Asn Leu Val Pro Ser Ser 
            180                 185                 190         


Met Leu Leu Arg Pro Ile His Ile Lys Ser Glu Asn Asn Ser Gly Ile 
        195                 200                 205             


Lys Asp Lys Gly Ser Ser Leu Ser Ala His Gly Pro Glu Ala His Ala 
    210                 215                 220                 


Thr Glu Thr His Cys His Glu Thr Glu Glu Ser Thr Ile Lys Asp Ser 
225                 230                 235                 240 


Thr Thr Gln Lys Ala Gly Leu Pro Ser Lys Asn Leu Thr Val Ser Gln 
                245                 250                 255     


Asn Gln Ser Glu Glu Phe Tyr Asn Gly Pro Asn Arg Asn Arg Leu Leu 
            260                 265                 270         


Leu Lys Ser Asp Glu Glu Ser Asp Lys Val Ile Ser Trp Ser Cys Lys 
        275                 280                 285             


Gln Leu Phe Asp Ile Ser Leu Phe Arg Asn Pro Phe Phe Tyr Ile Phe 
    290                 295                 300                 


Thr Trp Ser Phe Leu Leu Ser Gln Leu Ala Tyr Phe Ile Pro Thr Phe 
305                 310                 315                 320 


His Leu Val Ala Arg Ala Lys Thr Leu Gly Ile Asp Ile Met Asp Ala 
                325                 330                 335     


Ser Tyr Leu Val Ser Val Ala Gly Ile Leu Glu Thr Val Ser Gln Ile 
            340                 345                 350         


Ile Ser Gly Trp Val Ala Asp Gln Asn Trp Ile Lys Lys Tyr His Tyr 
        355                 360                 365             


His Lys Ser Tyr Leu Ile Leu Cys Gly Ile Thr Asn Leu Leu Ala Pro 
    370                 375                 380                 


Leu Ala Thr Thr Phe Pro Leu Leu Met Thr Tyr Thr Ile Cys Phe Ala 
385                 390                 395                 400 


Ile Phe Ala Gly Gly Tyr Leu Ala Leu Ile Leu Pro Val Leu Val Asp 
                405                 410                 415     


Leu Cys Arg Asn Ser Thr Val Asn Arg Phe Leu Gly Leu Ala Ser Phe 
            420                 425                 430         


Phe Ala Gly Met Ala Val Leu Ser Gly Pro Pro Ile Ala Gly Trp Leu 
        435                 440                 445             


Tyr Asp Tyr Thr Gln Thr Tyr Asn Gly Ser Phe Tyr Phe Ser Gly Ile 
    450                 455                 460                 


Cys Tyr Leu Leu Ser Ser Val Ser Phe Phe Phe Val Pro Leu Ala Glu 
465                 470                 475                 480 


Arg Trp Lys Asn Ser Leu Thr 
                485         


<210>  466
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  466

Met Asp Gly Lys Pro Ala Thr Arg Lys Gly Pro Asp Phe Cys Ser Leu 
1               5                   10                  15      


Arg Tyr Gly Leu Ala Leu Ile Met His Phe Ser Asn Phe Thr Met Ile 
            20                  25                  30          


Thr Gln Arg Val Ser Leu Ser Ile Ala Ile Ile Ala Met Val Asn Thr 
        35                  40                  45              


Thr Gln Gln Gln Gly Leu Ser Asn Ala Ser Thr Glu Gly Pro Val Ala 
    50                  55                  60                  


Asp Ala Phe Asn Asn Ser Ser Ile Ser Ile Lys Glu Phe Asp Thr Lys 
65                  70                  75                  80  


Ala Ser Val Tyr Gln Trp Ser Pro Glu Thr Gln Gly Ile Ile Phe Ser 
                85                  90                  95      


Ser Ile Asn Tyr Gly Ile Ile Leu Thr Leu Ile Pro Ser Gly Tyr Leu 
            100                 105                 110         


Ala Gly Ile Phe Gly Ala Lys Lys Met Leu Gly Ala Gly Leu Leu Ile 
        115                 120                 125             


Ser Ser Leu Leu Thr Leu Phe Thr Pro Leu Ala Ala Asp Phe Gly Val 
    130                 135                 140                 


Ile Leu Val Ile Met Val Arg Thr Val Gln Gly Met Ala Gln Gly Met 
145                 150                 155                 160 


Ala Trp Thr Gly Gln Phe Thr Ile Trp Ala Lys Trp Ala Pro Pro Leu 
                165                 170                 175     


Glu Arg Ser Lys Leu Thr Thr Ile Ala Gly Ser Gly Ser Ala Phe Gly 
            180                 185                 190         


Ser Phe Ile Ile Leu Cys Val Gly Gly Leu Ile Ser Gln Ala Leu Ser 
        195                 200                 205             


Trp Pro Phe Ile Phe Tyr Ile Phe Gly Ser Thr Gly Cys Val Cys Cys 
    210                 215                 220                 


Leu Leu Trp Phe Thr Val Ile Tyr Asp Asp Pro Met His His Pro Cys 
225                 230                 235                 240 


Ile Ser Val Arg Glu Lys Glu His Ile Leu Ser Ser Leu Ala Gln Gln 
                245                 250                 255     


Pro Ser Ser Pro Gly Arg Ala Val Pro Ile Lys Ala Met Val Thr Cys 
            260                 265                 270         


Leu Pro Leu Trp Ala Ile Phe Leu Gly Phe Phe Ser His Phe Trp Leu 
        275                 280                 285             


Cys Thr Ile Ile Leu Thr Tyr Leu Pro Thr Tyr Ile Ser Thr Leu Leu 
    290                 295                 300                 


His Val Asn Ile Arg Asp Ser Gly Val Leu Ser Ser Leu Pro Phe Ile 
305                 310                 315                 320 


Ala Ala Ala Ser Cys Thr Ile Leu Gly Gly Gln Leu Ala Asp Phe Leu 
                325                 330                 335     


Leu Ser Arg Asn Leu Leu Arg Leu Ile Thr Val Arg Lys Leu Phe Ser 
            340                 345                 350         


Ser Leu Gly Leu Leu Leu Pro Ser Ile Cys Ala Val Ala Leu Pro Phe 
        355                 360                 365             


Val Ala Ser Ser Tyr Val Ile Thr Ile Ile Leu Leu Ile Leu Ile Pro 
    370                 375                 380                 


Gly Thr Ser Asn Leu Cys Asp Ser Gly Phe Ile Ile Asn Thr Leu Asp 
385                 390                 395                 400 


Ile Ala Pro Arg Tyr Ala Ser Phe Leu Met Gly Ile Ser Arg Gly Phe 
                405                 410                 415     


Gly Leu Ile Ala Gly Ile Ile Ser Ser Thr Ala Thr Gly Phe Leu Ile 
            420                 425                 430         


Ser Gln Asp Phe Glu Ser Gly Trp Arg Asn Val Phe Phe Leu Ser Ala 
        435                 440                 445             


Ala Val Asn Met Phe Gly Leu Val Phe Tyr Leu Thr Phe Gly Gln Ala 
    450                 455                 460                 


Glu Leu Gln Asp Trp Ala Lys Glu Arg Thr Leu Thr Arg Leu 
465                 470                 475             


<210>  467
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  467

Met Asp Gly Lys Pro Ala Thr Arg Lys Gly Pro Asp Phe Cys Ser Leu 
1               5                   10                  15      


Arg Tyr Gly Leu Ala Leu Ile Met His Phe Ser Asn Phe Thr Met Ile 
            20                  25                  30          


Thr Gln Arg Val Ser Leu Ser Ile Ala Ile Ile Ala Met Val Asn Thr 
        35                  40                  45              


Thr Gln Gln Gln Gly Leu Ser Asn Ala Ser Thr Glu Gly Pro Val Ala 
    50                  55                  60                  


Asp Ala Phe Asn Asn Ser Ser Ile Ser Ile Lys Glu Phe Asp Thr Lys 
65                  70                  75                  80  


Ala Ser Val Tyr Gln Trp Ser Pro Glu Thr Gln Gly Ile Ile Phe Ser 
                85                  90                  95      


Ser Ile Asn Tyr Gly Ile Ile Leu Thr Leu Ile Pro Ser Gly Tyr Leu 
            100                 105                 110         


Ala Gly Ile Phe Gly Ala Lys Lys Met Leu Gly Ala Gly Leu Leu Ile 
        115                 120                 125             


Ser Ser Leu Leu Thr Leu Phe Thr Pro Leu Ala Ala Asp Phe Gly Val 
    130                 135                 140                 


Ile Leu Val Ile Met Val Arg Thr Val Gln Gly Met Ala Gln Gly Met 
145                 150                 155                 160 


Ala Trp Thr Gly Gln Phe Thr Ile Trp Ala Lys Trp Ala Pro Pro Leu 
                165                 170                 175     


Glu Arg Ser Lys Leu Thr Thr Ile Ala Gly Ser Gly Ser Ala Phe Gly 
            180                 185                 190         


Ser Phe Ile Ile Leu Cys Val Gly Gly Leu Ile Ser Gln Ala Leu Ser 
        195                 200                 205             


Trp Pro Phe Ile Phe Tyr Ile Phe Gly Ser Thr Gly Cys Val Cys Cys 
    210                 215                 220                 


Leu Leu Trp Phe Thr Val Ile Tyr Asp Asp Pro Met His His Pro Cys 
225                 230                 235                 240 


Ile Ser Val Arg Glu Lys Glu His Ile Leu Ser Ser Leu Ala Gln Gln 
                245                 250                 255     


Pro Ser Ser Pro Gly Arg Ala Val Pro Ile Lys Ala Met Val Thr Cys 
            260                 265                 270         


Leu Pro Leu Trp Ala Ile Phe Leu Gly Phe Phe Ser His Phe Trp Leu 
        275                 280                 285             


Cys Thr Ile Ile Leu Thr Tyr Leu Pro Thr Tyr Ile Ser Thr Leu Leu 
    290                 295                 300                 


His Val Asn Ile Arg Asp Ser Gly Val Leu Ser Ser Leu Pro Phe Ile 
305                 310                 315                 320 


Ala Ala Ala Ser Cys Thr Ile Leu Gly Gly Gln Leu Ala Asp Phe Leu 
                325                 330                 335     


Leu Ser Arg Asn Leu Leu Arg Leu Ile Thr Val Arg Lys Leu Phe Ser 
            340                 345                 350         


Ser Leu Asp Met Gln Val Ser Ser Trp Glu Ser Gln Gly Asp Leu Gly 
        355                 360                 365             


Ser Ser Gln Glu Ser Ser Leu Pro Leu Pro Leu Asp Ser Ser Ser Val 
    370                 375                 380                 


Arg Leu Gly Gln Phe Ile Glu His Leu Gln Val Ala Gly Phe 
385                 390                 395             


<210>  468
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  468

Met Asp Gly Lys Pro Ala Thr Arg Lys Gly Pro Asp Phe Cys Ser Leu 
1               5                   10                  15      


Arg Tyr Gly Leu Ala Leu Ile Met His Phe Ser Asn Phe Thr Met Ile 
            20                  25                  30          


Thr Gln Arg Val Ser Leu Ser Ile Ala Ile Ile Ala Met Val Asn Thr 
        35                  40                  45              


Thr Gln Gln Gln Gly Leu Ser Asn Ala Ser Thr Glu Gly Pro Val Ala 
    50                  55                  60                  


Asp Ala Phe Asn Asn Ser Ser Ile Ser Ile Lys Glu Phe Asp Thr Lys 
65                  70                  75                  80  


Ala Ser Val Tyr Gln Trp Ser Pro Glu Thr Gln Gly Ile Ile Phe Ser 
                85                  90                  95      


Ser Ile Asn Tyr Gly Ile Ile Leu Thr Leu Ile Pro Ser Gly Tyr Leu 
            100                 105                 110         


Ala Gly Ile Phe Gly Ala Lys Lys Met Leu Gly Ala Gly Leu Leu Ile 
        115                 120                 125             


Ser Ser Leu Leu Thr Leu Phe Thr Pro Leu Ala Ala Asp Phe Gly Val 
    130                 135                 140                 


Ile Leu Val Ile Met Val Arg Thr Val Gln Gly Met Ala Gln Gly Met 
145                 150                 155                 160 


Ala Trp Thr Gly Gln Phe Thr Ile Trp Ala Lys Trp Ala Pro Pro Leu 
                165                 170                 175     


Glu Arg Ser Lys Leu Thr Thr Ile Ala Gly Ser Gly Ser Ala Phe Gly 
            180                 185                 190         


Ser Phe Ile Ile Leu Cys Val Gly Gly Leu Ile Ser Gln Ala Leu Ser 
        195                 200                 205             


Trp Pro Phe Ile Phe Tyr Ile Phe Gly Ser Thr Gly Cys Val Cys Cys 
    210                 215                 220                 


Leu Leu Trp Phe Thr Val Ile Tyr Asp Asp Pro Met His His Pro Cys 
225                 230                 235                 240 


Ile Ser Val Arg Glu Lys Glu His Ile Leu Ser Ser Leu Ala Gln Gln 
                245                 250                 255     


Pro Ser Ser Pro Gly Arg Ala Val Pro Ile Lys Ala Met Val Thr Cys 
            260                 265                 270         


Leu Pro Leu Trp Ala Ile Phe Leu Gly Phe Phe Ser His Phe Trp Leu 
        275                 280                 285             


Cys Thr Ile Ile Leu Thr Tyr Leu Pro Thr Tyr Ile Ser Thr Leu Leu 
    290                 295                 300                 


His Val Asn Ile Arg Asp Ser Gly Val Leu Ser Ser Leu Pro Phe Ile 
305                 310                 315                 320 


Ala Ala Ala Ser Cys Thr Ile Leu Gly Gly Gln Leu Ala Asp Phe Leu 
                325                 330                 335     


Leu Ser Arg Asn Leu Leu Arg Leu Ile Thr Val Arg Lys Leu Phe Ser 
            340                 345                 350         


Ser Leu Asp Met Gln Val Ser Ser Trp Glu Ser Gln Gly Asp Leu Gly 
        355                 360                 365             


Ser Ser Gln Glu Ser Ser Leu Pro Leu Pro Leu Asp Ser Ser Ser Val 
    370                 375                 380                 


Arg Ile Leu Ser Leu Val Gly Gly Met Ser Phe Ser Cys Leu Leu Gln 
385                 390                 395                 400 


Ser Thr Cys Leu Ala Trp Ser Phe Thr Ser Arg Leu Asp Lys Gln Asn 
                405                 410                 415     


Phe Lys Thr Gly Pro Lys Arg Gly Pro Leu Pro Ala Ser Glu Asp Ile 
            420                 425                 430         


Lys Leu Gln Thr 
        435     


<210>  469
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  469

Met Thr Lys Ser Asn Gly Glu Glu Pro Lys Met Gly Gly Arg Met Glu 
1               5                   10                  15      


Arg Phe Gln Gln Gly Val Arg Lys Arg Thr Leu Leu Ala Lys Lys Lys 
            20                  25                  30          


Val Gln Asn Ile Thr Lys Glu Asp Val Lys Ser Tyr Leu Phe Arg Asn 
        35                  40                  45              


Ala Phe Val Leu Leu Thr Val Thr Ala Val Ile Val Gly Thr Ile Leu 
    50                  55                  60                  


Gly Phe Thr Leu Arg Pro Tyr Arg Met Ser Tyr Arg Glu Val Lys Tyr 
65                  70                  75                  80  


Phe Ser Phe Pro Gly Glu Leu Leu Met Arg Met Leu Gln Met Leu Val 
                85                  90                  95      


Leu Pro Leu Ile Ile Ser Ser Leu Val Thr Gly Met Ala Ala Leu Asp 
            100                 105                 110         


Ser Lys Ala Ser Gly Lys Met Gly Met Arg Ala Val Val Tyr Tyr Met 
        115                 120                 125             


Thr Thr Thr Ile Ile Ala Val Val Ile Gly Ile Ile Ile Val Ile Ile 
    130                 135                 140                 


Ile His Pro Gly Lys Gly Thr Lys Glu Asn Met His Arg Glu Gly Lys 
145                 150                 155                 160 


Ile Val Arg Val Thr Ala Ala Asp Ala Phe Leu Asp Leu Ile Arg Asn 
                165                 170                 175     


Met Phe Pro Pro Asn Leu Val Glu Ala Cys Phe Lys Gln Phe Lys Thr 
            180                 185                 190         


Asn Tyr Glu Lys Arg Ser Phe Lys Val Pro Ile Gln Ala Asn Glu Thr 
        195                 200                 205             


Leu Val Gly Ala Val Ile Asn Asn Val Ser Glu Ala Met Glu Thr Leu 
    210                 215                 220                 


Thr Arg Ile Thr Glu Glu Leu Val Pro Val Pro Gly Ser Val Asn Gly 
225                 230                 235                 240 


Val Asn Ala Leu Gly Leu Val Val Phe Ser Met Cys Phe Gly Phe Val 
                245                 250                 255     


Ile Gly Asn Met Lys Glu Gln Gly Gln Ala Leu Arg Glu Phe Phe Asp 
            260                 265                 270         


Ser Leu Asn Glu Ala Ile Met Arg Leu Val Ala Val Ile Met Trp Tyr 
        275                 280                 285             


Ala Pro Val Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Val Glu Met 
    290                 295                 300                 


Glu Asp Met Gly Val Ile Gly Gly Gln Leu Ala Met Tyr Thr Val Thr 
305                 310                 315                 320 


Val Ile Val Gly Leu Leu Ile His Ala Val Ile Val Leu Pro Leu Leu 
                325                 330                 335     


Tyr Phe Leu Val Thr Arg Lys Asn Pro Trp Val Phe Ile Gly Gly Leu 
            340                 345                 350         


Leu Gln Ala Leu Ile Thr Ala Leu Gly Thr Ser Ser Ser Ser Ala Thr 
        355                 360                 365             


Leu Pro Ile Thr Phe Lys Cys Leu Glu Glu Asn Asn Gly Val Asp Lys 
    370                 375                 380                 


Arg Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 
385                 390                 395                 400 


Gly Thr Ala Leu Tyr Glu Ala Leu Ala Ala Ile Phe Ile Ala Gln Val 
                405                 410                 415     


Asn Asn Phe Glu Leu Asn Phe Gly Gln Ile Ile Thr Ile Arg Asp Arg 
            420                 425                 430         


Leu Arg Thr Thr Thr Asn Val Leu Gly Asp Ser Leu Gly Ala Gly Ile 
        435                 440                 445             


Val Glu His Leu Ser Arg His Glu Leu Lys Asn Arg Asp Val Glu Met 
    450                 455                 460                 


Gly Asn Ser Val Ile Glu Glu Asn Glu Met Lys Lys Pro Tyr Gln Leu 
465                 470                 475                 480 


Ile Ala Gln Asp Asn Glu Thr Glu Lys Pro Ile Asp Ser Glu Thr Lys 
                485                 490                 495     


Met 
    


<210>  470
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  470

Met Thr Lys Ser Asn Gly Glu Glu Pro Lys Met Gly Gly Arg Met Glu 
1               5                   10                  15      


Arg Phe Gln Gln Gly Val Arg Lys Arg Thr Leu Leu Ala Lys Lys Lys 
            20                  25                  30          


Val Gln Asn Ile Thr Lys Glu Asp Val Lys Ser Tyr Leu Phe Arg Asn 
        35                  40                  45              


Ala Phe Val Leu Leu Thr Val Thr Ala Val Ile Val Gly Thr Ile Leu 
    50                  55                  60                  


Gly Phe Thr Leu Arg Pro Tyr Arg Met Ser Tyr Arg Glu Val Lys Tyr 
65                  70                  75                  80  


Phe Ser Phe Pro Gly Glu Leu Leu Met Arg Met Leu Gln Met Leu Val 
                85                  90                  95      


Leu Pro Leu Ile Ile Ser Ser Leu Val Thr Gly Met Ala Ala Leu Asp 
            100                 105                 110         


Ser Lys Ala Ser Gly Lys Met Gly Met Arg Ala Val Val Tyr Tyr Met 
        115                 120                 125             


Thr Thr Thr Ile Ile Ala Val Val Ile Gly Ile Ile Ile Val Ile Ile 
    130                 135                 140                 


Ile His Pro Gly Lys Gly Thr Lys Glu Asn Met His Arg Glu Gly Lys 
145                 150                 155                 160 


Ile Val Arg Val Thr Ala Ala Asp Ala Phe Leu Asp Leu Ile Arg Tyr 
                165                 170                 175     


Ala Pro Val Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Val Glu Met 
            180                 185                 190         


Glu Asp Met Gly Val Ile Gly Gly Gln Leu Ala Met Tyr Thr Val Thr 
        195                 200                 205             


Val Ile Val Gly Leu Leu Ile His Ala Val Ile Val Leu Pro Leu Leu 
    210                 215                 220                 


Tyr Phe Leu Val Thr Arg Lys Asn Pro Trp Val Phe Ile Gly Gly Leu 
225                 230                 235                 240 


Leu Gln Ala Leu Ile Thr Ala Leu Gly Thr Ser Ser Ser Ser Ala Thr 
                245                 250                 255     


Leu Pro Ile Thr Phe Lys Cys Leu Glu Glu Asn Asn Gly Val Asp Lys 
            260                 265                 270         


Arg Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 
        275                 280                 285             


Gly Thr Ala Leu Tyr Glu Ala Leu Ala Ala Ile Phe Ile Ala Gln Val 
    290                 295                 300                 


Asn Asn Phe Glu Leu Asn Phe Gly Gln Ile Ile Thr Ile Ser Ile Thr 
305                 310                 315                 320 


Ala Thr Ala Ala Ser Ile Gly Ala Ala Gly Ile Pro Gln Ala Gly Leu 
                325                 330                 335     


Val Thr Met Val Ile Val Leu Thr Ser Val Gly Leu Pro Thr Asp Asp 
            340                 345                 350         


Ile Thr Leu Ile Ile Ala Val Asp Trp Phe Leu Asp Arg Leu Arg Thr 
        355                 360                 365             


Thr Thr Asn Val Leu Gly Asp Ser Leu Gly Ala Gly Ile Val Glu His 
    370                 375                 380                 


Leu Ser Arg His Glu Leu Lys Asn Arg Asp Val Glu Met Gly Asn Ser 
385                 390                 395                 400 


Val Ile Glu Glu Asn Glu Met Lys Lys Pro Tyr Gln Leu Ile Ala Gln 
                405                 410                 415     


Asp Asn Glu Thr Glu Lys Pro Ile Asp Ser Glu Thr Lys Met 
            420                 425                 430 


<210>  471
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  471

Met Thr Lys Ser Asn Gly Glu Glu Pro Lys Met Gly Gly Arg Met Glu 
1               5                   10                  15      


Arg Phe Gln Gln Gly Val Arg Lys Arg Thr Leu Leu Ala Lys Lys Lys 
            20                  25                  30          


Val Gln Asn Ile Thr Lys Glu Asp Val Lys Ser Tyr Leu Phe Arg Asn 
        35                  40                  45              


Ala Phe Val Leu Leu Thr Val Thr Ala Val Ile Val Gly Thr Ile Leu 
    50                  55                  60                  


Gly Phe Thr Leu Arg Pro Tyr Arg Met Ser Tyr Arg Glu Val Lys Tyr 
65                  70                  75                  80  


Phe Ser Phe Pro Gly Glu Leu Leu Met Arg Met Leu Gln Met Leu Val 
                85                  90                  95      


Leu Pro Leu Ile Ile Ser Ser Leu Val Thr Gly Met Ala Ala Leu Asp 
            100                 105                 110         


Ser Lys Ala Ser Gly Lys Met Gly Met Arg Ala Val Val Tyr Tyr Met 
        115                 120                 125             


Thr Thr Thr Ile Ile Ala Val Val Ile Gly Ile Ile Ile Val Ile Ile 
    130                 135                 140                 


Ile His Pro Gly Lys Gly Thr Lys Glu Asn Met His Arg Glu Gly Lys 
145                 150                 155                 160 


Ile Val Arg Val Thr Ala Ala Asp Ala Phe Leu Asp Leu Ile Arg Asn 
                165                 170                 175     


Met Phe Pro Pro Asn Leu Val Glu Ala Cys Phe Lys Gln Phe Lys Thr 
            180                 185                 190         


Asn Tyr Glu Lys Arg Ser Phe Lys Val Pro Ile Gln Ala Asn Glu Thr 
        195                 200                 205             


Leu Val Gly Ala Val Ile Asn Asn Val Ser Glu Ala Met Glu Thr Leu 
    210                 215                 220                 


Thr Arg Ile Thr Glu Glu Leu Val Pro Val Pro Gly Ser Val Asn Gly 
225                 230                 235                 240 


Val Asn Ala Leu Gly Leu Val Val Phe Ser Met Cys Phe Gly Phe Val 
                245                 250                 255     


Ile Gly Asn Met Lys Glu Gln Gly Gln Ala Leu Arg Glu Phe Phe Asp 
            260                 265                 270         


Ser Leu Asn Glu Ala Ile Met Arg Leu Val Ala Val Ile Met Trp Tyr 
        275                 280                 285             


Ala Pro Val Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Val Glu Met 
    290                 295                 300                 


Glu Asp Met Gly Val Ile Gly Gly Gln Leu Ala Met Tyr Thr Val Thr 
305                 310                 315                 320 


Val Ile Val Gly Leu Leu Ile His Ala Val Ile Val Leu Pro Leu Leu 
                325                 330                 335     


Tyr Phe Leu Val Thr Arg Lys Asn Pro Trp Val Phe Ile Gly Gly Leu 
            340                 345                 350         


Leu Gln Ala Leu Ile Thr Ala Leu Gly Thr Ser Ser Ser Ser Ala Thr 
        355                 360                 365             


Leu Pro Ile Thr Phe Lys Cys Leu Glu Glu Asn Asn Gly Val Asp Lys 
    370                 375                 380                 


Arg Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 
385                 390                 395                 400 


Gly Thr Ala Leu Tyr Glu Ala Leu Ala Ala Ile Phe Ile Ala Gln Val 
                405                 410                 415     


Asn Asn Phe Glu Leu Asn Phe Gly Gln Ile Ile Thr Ile Ser Ile Thr 
            420                 425                 430         


Ala Thr Ala Ala Ser Ile Gly Ala Ala Gly Ile Pro Gln Ala Gly Leu 
        435                 440                 445             


Val Thr Met Val Ile Val Leu Thr Ser Val Gly Leu Pro Thr Asp Asp 
    450                 455                 460                 


Ile Thr Leu Ile Ile Ala Val Asp Trp Phe Leu Asp Arg Leu Arg Thr 
465                 470                 475                 480 


Thr Thr Asn Val Leu Gly Asp Ser Leu Gly Ala Gly Ile Val Glu His 
                485                 490                 495     


Leu Ser Arg His Glu Leu Lys Asn Arg Asp Val Glu Met Gly Asn Ser 
            500                 505                 510         


Val Ile Glu Glu Asn Glu Met Lys Lys Pro Tyr Gln Leu Ile Ala Gln 
        515                 520                 525             


Asp Asn Glu Thr Glu Lys Pro Ile Asp Ser Glu Thr Lys Met 
    530                 535                 540         


<210>  472
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  472

Met Pro Thr Thr Val Asp Asp Val Leu Glu His Gly Gly Glu Phe His 
1               5                   10                  15      


Phe Phe Gln Lys Gln Met Phe Phe Leu Leu Ala Leu Leu Ser Ala Thr 
            20                  25                  30          


Phe Ala Pro Ile Tyr Val Gly Ile Val Phe Leu Gly Phe Thr Pro Asp 
        35                  40                  45              


His Arg Cys Arg Ser Pro Gly Val Ala Glu Leu Ser Leu Arg Cys Gly 
    50                  55                  60                  


Trp Ser Pro Ala Glu Glu Leu Asn Tyr Thr Val Pro Gly Pro Gly Pro 
65                  70                  75                  80  


Ala Gly Glu Ala Ser Pro Arg Gln Cys Arg Arg Tyr Glu Val Asp Trp 
                85                  90                  95      


Asn Gln Ser Thr Phe Asp Cys Val Asp Pro Leu Ala Ser Leu Asp Thr 
            100                 105                 110         


Asn Arg Ser Arg Leu Pro Leu Gly Pro Cys Arg Asp Gly Trp Val Tyr 
        115                 120                 125             


Glu Thr Pro Gly Ser Ser Ile Val Thr Glu Phe Asn Leu Val Cys Ala 
    130                 135                 140                 


Asn Ser Trp Met Leu Asp Leu Phe Gln Ser Ser Val Asn Val Gly Phe 
145                 150                 155                 160 


Phe Ile Gly Ser Met Ser Ile Gly Tyr Ile Ala Asp Arg Phe Gly Arg 
                165                 170                 175     


Lys Leu Cys Leu Leu Thr Thr Val Leu Ile Asn Ala Ala Ala Gly Val 
            180                 185                 190         


Leu Met Ala Ile Ser Pro Thr Tyr Thr Trp Met Leu Ile Phe Arg Leu 
        195                 200                 205             


Ile Gln Gly Leu Val Ser Lys Ala Gly Trp Leu Ile Gly Tyr Ile Leu 
    210                 215                 220                 


Ile Thr Glu Phe Val Gly Arg Arg Tyr Arg Arg Thr Val Gly Ile Phe 
225                 230                 235                 240 


Tyr Gln Val Ala Tyr Thr Val Gly Leu Leu Val Leu Ala Gly Val Ala 
                245                 250                 255     


Tyr Ala Leu Pro His Trp Arg Trp Leu Gln Phe Thr Val Ser Leu Pro 
            260                 265                 270         


Asn Phe Phe Phe Leu Leu Tyr Tyr Trp Cys Ile Pro Glu Ser Pro Arg 
        275                 280                 285             


Trp Leu Ile Ser Gln Asn Lys Asn Ala Glu Ala Met Arg Ile Ile Lys 
    290                 295                 300                 


His Ile Ala Lys Lys Asn Gly Lys Ser Leu Pro Ala Ser Leu Gln Arg 
305                 310                 315                 320 


Leu Arg Leu Glu Glu Glu Thr Gly Lys Lys Leu Asn Pro Ser Phe Leu 
                325                 330                 335     


Asp Leu Val Arg Thr Pro Gln Ile Arg Lys His Thr Met Ile Leu Met 
            340                 345                 350         


Tyr Asn Trp Phe Thr Ser Ser Val Leu Tyr Gln Gly Leu Ile Met His 
        355                 360                 365             


Met Gly Leu Ala Gly Asp Asn Ile Tyr Leu Asp Phe Phe Tyr Ser Ala 
    370                 375                 380                 


Leu Val Glu Phe Pro Ala Ala Phe Met Ile Ile Leu Thr Ile Asp Arg 
385                 390                 395                 400 


Ile Gly Arg Arg Tyr Pro Trp Ala Ala Ser Asn Met Val Ala Gly Ala 
                405                 410                 415     


Ala Cys Leu Ala Ser Val Phe Ile Pro Gly Asp Leu Gln Trp Leu Lys 
            420                 425                 430         


Ile Ile Ile Ser Cys Leu Gly Arg Met Gly Ile Thr Met Ala Tyr Glu 
        435                 440                 445             


Ile Val Cys Leu Val Asn Ala Glu Leu Tyr Pro Thr Phe Ile Arg Asn 
    450                 455                 460                 


Leu Gly Val His Ile Cys Ser Ser Met Cys Asp Ile Gly Gly Ile Ile 
465                 470                 475                 480 


Thr Pro Phe Leu Val Tyr Arg Leu Thr Asn Ile Trp Leu Glu Leu Pro 
                485                 490                 495     


Leu Met Val Phe Gly Val Leu Gly Leu Val Ala Gly Gly Leu Val Leu 
            500                 505                 510         


Leu Leu Pro Glu Thr Lys Gly Lys Ala Leu Pro Glu Thr Ile Glu Glu 
        515                 520                 525             


Ala Glu Asn Met Gln Arg Pro Arg Lys Asn Lys Glu Lys Met Ile Tyr 
    530                 535                 540                 


Leu Gln Val Gln Lys Leu Asp Ile Pro Leu Asn 
545                 550                 555 


<210>  473
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  473

Met Ser Gln Pro Arg Pro Arg Tyr Val Val Asp Arg Ala Ala Tyr Ser 
1               5                   10                  15      


Leu Thr Leu Phe Asp Asp Glu Phe Glu Lys Lys Asp Arg Thr Tyr Pro 
            20                  25                  30          


Val Gly Glu Lys Leu Arg Asn Ala Phe Arg Cys Ser Ser Ala Lys Ile 
        35                  40                  45              


Lys Ala Val Val Phe Gly Leu Leu Pro Val Leu Ser Trp Leu Pro Lys 
    50                  55                  60                  


Tyr Lys Ile Lys Asp Tyr Ile Ile Pro Asp Leu Leu Gly Gly Leu Ser 
65                  70                  75                  80  


Gly Gly Ser Ile Gln Val Pro Gln Gly Met Ala Phe Ala Leu Leu Ala 
                85                  90                  95      


Asn Leu Pro Ala Val Asn Gly Leu Tyr Ser Ser Phe Phe Pro Leu Leu 
            100                 105                 110         


Thr Tyr Phe Phe Leu Gly Gly Val His Gln Met Val Pro Gly Thr Phe 
        115                 120                 125             


Ala Val Ile Ser Ile Leu Val Gly Asn Ile Cys Leu Gln Leu Ala Pro 
    130                 135                 140                 


Glu Ser Lys Phe Gln Val Phe Asn Asn Ala Thr Asn Glu Ser Tyr Val 
145                 150                 155                 160 


Asp Thr Ala Ala Met Glu Ala Glu Arg Leu His Val Ser Ala Thr Leu 
                165                 170                 175     


Ala Cys Leu Thr Ala Ile Ile Gln Met Gly Leu Gly Phe Met Gln Phe 
            180                 185                 190         


Gly Phe Val Ala Ile Tyr Leu Ser Glu Ser Phe Ile Arg Gly Phe Met 
        195                 200                 205             


Thr Ala Ala Gly Leu Gln Ile Leu Ile Ser Val Leu Lys Tyr Ile Phe 
    210                 215                 220                 


Gly Leu Thr Ile Pro Ser Tyr Thr Gly Pro Gly Ser Ile Val Phe Thr 
225                 230                 235                 240 


Phe Ile Asp Ile Cys Lys Asn Leu Pro His Thr Asn Ile Ala Ser Leu 
                245                 250                 255     


Ile Phe Ala Leu Ile Ser Gly Ala Phe Leu Val Leu Val Lys Glu Leu 
            260                 265                 270         


Asn Ala Arg Tyr Met His Lys Ile Arg Phe Pro Ile Pro Thr Glu Met 
        275                 280                 285             


Ile Val Val Val Val Ala Thr Ala Ile Ser Gly Gly Cys Lys Met Pro 
    290                 295                 300                 


Lys Lys Tyr His Met Gln Ile Val Gly Glu Ile Gln Arg Gly Phe Pro 
305                 310                 315                 320 


Thr Pro Val Ser Pro Val Val Ser Gln Trp Lys Asp Met Ile Gly Thr 
                325                 330                 335     


Ala Phe Ser Leu Ala Ile Val Ser Tyr Val Ile Asn Leu Ala Met Gly 
            340                 345                 350         


Arg Thr Leu Ala Asn Lys His Gly Tyr Asp Val Asp Ser Asn Gln Glu 
        355                 360                 365             


Met Ile Ala Leu Gly Cys Ser Asn Phe Phe Gly Ser Phe Phe Lys Ile 
    370                 375                 380                 


His Val Ile Cys Cys Ala Leu Ser Val Thr Leu Ala Val Asp Gly Ala 
385                 390                 395                 400 


Gly Gly Lys Ser Gln Val Ala Ser Leu Cys Val Ser Leu Val Val Met 
                405                 410                 415     


Ile Thr Met Leu Val Leu Gly Ile Tyr Leu Tyr Pro Leu Pro Lys Ser 
            420                 425                 430         


Val Leu Gly Ala Leu Ile Ala Val Asn Leu Lys Asn Ser Leu Lys Gln 
        435                 440                 445             


Leu Thr Asp Pro Tyr Tyr Leu Trp Arg Lys Ser Lys Leu Asp Cys Cys 
    450                 455                 460                 


Ile Trp Val Val Ser Phe Leu Ser Ser Phe Phe Leu Ser Leu Pro Tyr 
465                 470                 475                 480 


Gly Val Ala Val Gly Val Ala Phe Ser Val Leu Val Val Val Phe Gln 
                485                 490                 495     


Thr Gln Phe Arg Asn Gly Tyr Ala Leu Ala Gln Val Met Asp Thr Asp 
            500                 505                 510         


Ile Tyr Val Asn Pro Lys Thr Tyr Asn Arg Ala Gln Asp Ile Gln Gly 
        515                 520                 525             


Ile Lys Ile Ile Thr Tyr Cys Ser Pro Leu Tyr Phe Ala Asn Ser Glu 
    530                 535                 540                 


Ile Phe Arg Gln Lys Val Ile Ala Lys Thr Gly Met Asp Pro Gln Lys 
545                 550                 555                 560 


Val Leu Leu Ala Lys Gln Lys Tyr Leu Lys Lys Gln Glu Lys Arg Arg 
                565                 570                 575     


Met Arg Pro Thr Gln Gln Arg Arg Ser Leu Phe Met Lys Thr Lys Thr 
            580                 585                 590         


Val Ser Leu Gln Glu Leu Gln Gln Asp Phe Glu Asn Ala Pro Pro Thr 
        595                 600                 605             


Asp Pro Asn Asn Asn Gln Thr Pro Ala Asn Gly Thr Ser Val Ser Tyr 
    610                 615                 620                 


Ile Thr Phe Ser Pro Asp Ser Ser Ser Pro Ala Gln Ser Glu Pro Pro 
625                 630                 635                 640 


Ala Ser Ala Glu Ala Pro Gly Glu Pro Ser Asp Met Leu Ala Ser Val 
                645                 650                 655     


Pro Pro Phe Val Thr Phe His Thr Leu Ile Leu Asp Met Ser Gly Val 
            660                 665                 670         


Ser Phe Val Asp Leu Met Gly Ile Lys Ala Leu Ala Lys Leu Ser Ser 
        675                 680                 685             


Thr Tyr Gly Lys Ile Gly Val Lys Val Phe Leu Val Asn Ile His Ala 
    690                 695                 700                 


Gln Val Tyr Asn Asp Ile Ser His Gly Gly Val Phe Glu Asp Gly Ser 
705                 710                 715                 720 


Leu Glu Cys Lys His Val Phe Pro Ser Ile His Asp Ala Val Leu Phe 
                725                 730                 735     


Ala Gln Ala Asn Ala Arg Asp Val Thr Pro Gly His Asn Phe Gln Gly 
            740                 745                 750         


Ala Pro Gly Asp Ala Glu Leu Ser Leu Tyr Asp Ser Glu Glu Asp Ile 
        755                 760                 765             


Arg Ser Tyr Trp Asp Leu Glu Gln Glu Met Phe Gly Ser Met Phe His 
    770                 775                 780                 


Ala Glu Thr Leu Thr Ala Leu 
785                 790     


<210>  474
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  474

Met Ser Gln Pro Arg Pro Arg Tyr Val Val Asp Arg Ala Ala Tyr Ser 
1               5                   10                  15      


Leu Thr Leu Phe Asp Asp Glu Phe Glu Lys Lys Asp Arg Thr Tyr Pro 
            20                  25                  30          


Val Gly Glu Lys Leu Arg Asn Ala Phe Arg Cys Ser Ser Ala Lys Ile 
        35                  40                  45              


Lys Ala Val Val Phe Gly Leu Leu Pro Val Leu Ser Trp Leu Pro Lys 
    50                  55                  60                  


Tyr Lys Ile Lys Asp Tyr Ile Ile Pro Asp Leu Leu Gly Gly Leu Ser 
65                  70                  75                  80  


Gly Gly Ser Ile Gln Val Pro Gln Gly Met Ala Phe Ala Leu Leu Ala 
                85                  90                  95      


Asn Leu Pro Ala Val Asn Gly Leu Tyr Ser Ser Phe Phe Pro Leu Leu 
            100                 105                 110         


Thr Tyr Phe Phe Leu Gly Gly Val His Gln Met Val Pro Gly Thr Phe 
        115                 120                 125             


Ala Val Ile Ser Ile Leu Val Gly Asn Ile Cys Leu Gln Leu Ala Pro 
    130                 135                 140                 


Glu Ser Lys Phe Gln Val Phe Asn Asn Ala Thr Asn Glu Ser Tyr Val 
145                 150                 155                 160 


Asp Thr Ala Ala Met Glu Ala Glu Arg Leu His Val Ser Ala Thr Leu 
                165                 170                 175     


Ala Cys Leu Thr Ala Ile Ile Gln Met Gly Leu Gly Phe Met Gln Phe 
            180                 185                 190         


Gly Phe Val Ala Ile Tyr Leu Ser Glu Ser Phe Ile Arg Gly Phe Met 
        195                 200                 205             


Thr Ala Ala Gly Leu Gln Ile Leu Ile Ser Val Leu Lys Tyr Ile Phe 
    210                 215                 220                 


Gly Leu Thr Ile Pro Ser Tyr Thr Gly Pro Gly Ser Ile Val Phe Thr 
225                 230                 235                 240 


Phe Ile Asp Ile Cys Lys Asn Leu Pro His Thr Asn Ile Ala Ser Leu 
                245                 250                 255     


Ile Phe Ala Leu Ile Ser Gly Ala Phe Leu Val Leu Val Lys Glu Leu 
            260                 265                 270         


Asn Ala Arg Tyr Met His Lys Ile Arg Phe Pro Ile Pro Thr Glu Met 
        275                 280                 285             


Ile Val Val Val Val Ala Thr Ala Ile Ser Gly Gly Cys Lys Met Pro 
    290                 295                 300                 


Lys Lys Tyr His Met Gln Ile Val Gly Glu Ile Gln Arg Gly Phe Pro 
305                 310                 315                 320 


Thr Pro Val Ser Pro Val Val Ser Gln Trp Lys Asp Met Ile Gly Thr 
                325                 330                 335     


Ala Phe Ser Leu Ala Ile Val Ser Tyr Val Ile Asn Leu Ala Met Gly 
            340                 345                 350         


Arg Thr Leu Ala Asn Lys His Gly Tyr Asp Val Asp Ser Asn Gln Glu 
        355                 360                 365             


Met Ile Ala Leu Gly Cys Ser Asn Phe Phe Gly Ser Phe Phe Lys Ile 
    370                 375                 380                 


His Val Ile Cys Cys Ala Leu Ser Val Thr Leu Ala Val Asp Gly Ala 
385                 390                 395                 400 


Gly Gly Lys Ser Gln Val Ala Ser Leu Cys Val Ser Leu Val Val Met 
                405                 410                 415     


Ile Thr Met Leu Val Leu Gly Ile Tyr Leu Tyr Pro Leu Pro Lys Ser 
            420                 425                 430         


Val Leu Gly Ala Leu Ile Ala Val Asn Leu Lys Asn Ser Leu Lys Gln 
        435                 440                 445             


Leu Thr Asp Pro Tyr Tyr Leu Trp Arg Lys Ser Lys Leu Asp Cys Cys 
    450                 455                 460                 


Ile Trp Val Val Ser Phe Leu Ser Ser Phe Phe Leu Ser Leu Pro Tyr 
465                 470                 475                 480 


Gly Val Ala Val Gly Val Ala Phe Ser Val Leu Val Val Val Phe Gln 
                485                 490                 495     


Thr Gln Phe Arg Asn Gly Tyr Ala Leu Ala Gln Val Met Asp Thr Asp 
            500                 505                 510         


Ile Tyr Val Asn Pro Lys Thr Tyr Asn Arg Ala Gln Asp Ile Gln Gly 
        515                 520                 525             


Ile Lys Ile Ile Thr Tyr Cys Ser Pro Leu Tyr Phe Ala Asn Ser Glu 
    530                 535                 540                 


Ile Phe Arg Gln Lys Val Ile Ala Lys Thr Gly Met Asp Pro Gln Lys 
545                 550                 555                 560 


Val Leu Leu Ala Lys Gln Lys Tyr Leu Lys Lys Gln Glu Lys Arg Arg 
                565                 570                 575     


Met Arg Pro Thr Gln Gln Arg Arg Ser Leu Phe Met Lys Thr Lys Thr 
            580                 585                 590         


Val Ser Leu Gln Glu Leu Gln Gln Asp Phe Glu Asn Ala Pro Pro Thr 
        595                 600                 605             


Asp Pro Asn Asn Asn Gln Thr Pro Ala Asn Gly Thr Ser Val Ser Tyr 
    610                 615                 620                 


Ile Thr Phe Ser Pro Asp Ser Ser Ser Pro Ala Gln Ser Glu Pro Pro 
625                 630                 635                 640 


Ala Ser Ala Glu Ala Pro Gly Glu Pro Ser Asp Met Leu Ala Ser Val 
                645                 650                 655     


Pro Pro Phe Val Thr Phe His Thr Leu Ile Leu Asp Met Ser Gly Val 
            660                 665                 670         


Ser Phe Val Asp Leu Met Gly Ile Lys Ala Leu Ala Lys Leu Ser Ser 
        675                 680                 685             


Thr Tyr Gly Lys Ile Gly Val Lys Val Phe Leu Val Asn Ile His Ala 
    690                 695                 700                 


Gln Val Tyr Asn Asp Ile Ser His Gly Gly Val Phe Glu Asp Gly Ser 
705                 710                 715                 720 


Leu Glu Cys Lys His Val Phe Pro Ser Ile His Asp Ala Val Leu Phe 
                725                 730                 735     


Ala Gln Ala Asn Ala Arg Asp Val Thr Pro Gly His Asn Phe Gln Gly 
            740                 745                 750         


Ala Pro Gly Asp Ala Glu Leu Ser Leu Tyr Asp Ser Glu Glu Asp Ile 
        755                 760                 765             


Arg Ser Tyr Trp Asp Leu Glu Gln Glu Met Phe Gly Ser Met Phe His 
    770                 775                 780                 


Ala Glu Thr Leu Thr Ala Leu Glu Ser Leu Ser Ala Ala Gly Gly Cys 
785                 790                 795                 800 


Tyr Pro Tyr Arg Ser Glu Ser Leu Val Ser Pro Leu Phe Thr Arg Gln 
                805                 810                 815     


Ala Leu Ala Ala Met Asp Lys Pro Pro Ala His Ser Thr Pro Pro Thr 
            820                 825                 830         


Ser Ala Leu Ser Leu Ala Ala Glu Gly His Leu Asp Phe Gln Leu Leu 
        835                 840                 845             


Arg Val Ser Gln Lys Gln Lys Asp Lys Tyr Asn Cys Ala Gly Leu Leu 
    850                 855                 860                 


Tyr Lys Leu Gln Lys Val Ser Gln Ser Pro His Gly Ser Val Ser Asp 
865                 870                 875                 880 


Gly Val Arg Leu Ser Arg Thr 
                885         


<210>  475
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  475

Met Glu Leu Arg Ser Thr Ala Ala Pro Arg Ala Glu Gly Tyr Ser Asn 
1               5                   10                  15      


Val Gly Phe Gln Asn Glu Glu Asn Phe Leu Glu Asn Glu Asn Thr Ser 
            20                  25                  30          


Gly Asn Asn Ser Ile Arg Ser Arg Ala Val Gln Ser Arg Glu His Thr 
        35                  40                  45              


Asn Thr Lys Gln Asp Glu Glu Gln Val Thr Val Glu Gln Asp Ser Pro 
    50                  55                  60                  


Arg Asn Arg Glu His Met Glu Asp Asp Asp Glu Glu Met Gln Gln Lys 
65                  70                  75                  80  


Gly Cys Leu Glu Arg Arg Tyr Asp Thr Val Cys Gly Phe Cys Arg Lys 
                85                  90                  95      


His Lys Thr Thr Leu Arg His Ile Ile Trp Gly Ile Leu Leu Ala Gly 
            100                 105                 110         


Tyr Leu Val Met Val Ile Ser Ala Cys Val Leu Asn Phe His Arg Ala 
        115                 120                 125             


Leu Pro Leu Phe Val Ile Thr Val Ala Ala Ile Phe Phe Val Val Trp 
    130                 135                 140                 


Asp His Leu Met Ala Lys Tyr Glu His Arg Ile Asp Glu Met Leu Ser 
145                 150                 155                 160 


Pro Gly Arg Arg Leu Leu Asn Ser His Trp Phe Trp Leu Lys Trp Val 
                165                 170                 175     


Ile Trp Ser Ser Leu Val Leu Ala Val Ile Phe Trp Leu Ala Phe Asp 
            180                 185                 190         


Thr Ala Lys Leu Gly Gln Gln Gln Leu Val Ser Phe Gly Gly Leu Ile 
        195                 200                 205             


Met Tyr Ile Val Leu Leu Phe Leu Phe Ser Lys Tyr Pro Thr Arg Val 
    210                 215                 220                 


Tyr Trp Arg Pro Val Leu Trp Gly Ile Gly Leu Gln Phe Leu Leu Gly 
225                 230                 235                 240 


Leu Leu Ile Leu Arg Thr Asp Pro Gly Phe Ile Ala Phe Asp Trp Leu 
                245                 250                 255     


Gly Arg Gln Val Gln Thr Phe Leu Glu Tyr Thr Asp Ala Gly Ala Ser 
            260                 265                 270         


Phe Val Phe Gly Glu Lys Tyr Lys Asp His Phe Phe Ala Phe Lys Val 
        275                 280                 285             


Leu Pro Ile Val Val Phe Phe Ser Thr Val Met Ser Met Leu Tyr Tyr 
    290                 295                 300                 


Leu Gly Leu Met Gln Trp Ile Ile Arg Lys Val Gly Trp Ile Met Leu 
305                 310                 315                 320 


Val Thr Thr Gly Ser Ser Pro Ile Glu Ser Val Val Ala Ser Gly Asn 
                325                 330                 335     


Ile Phe Val Gly Gln Thr Glu Ser Pro Leu Leu Val Arg Pro Tyr Leu 
            340                 345                 350         


Pro Tyr Ile Thr Lys Ser Glu Leu His Ala Ile Met Thr Ala Gly Phe 
        355                 360                 365             


Ser Thr Ile Ala Gly Ser Val Leu Gly Ala Tyr Ile Ser Phe Gly Val 
    370                 375                 380                 


Pro Ser Ser His Leu Leu Thr Ala Ser Val Met Ser Ala Pro Ala Ser 
385                 390                 395                 400 


Leu Ala Ala Ala Lys Leu Phe Trp Pro Glu Thr Glu Lys Pro Lys Ile 
                405                 410                 415     


Thr Leu Lys Asn Ala Met Lys Met Glu Ser Gly Asp Ser Gly Asn Leu 
            420                 425                 430         


Leu Glu Ala Ala Thr Gln Gly Ala Ser Ser Ser Ile Ser Leu Val Ala 
        435                 440                 445             


Asn Ile Ala Val Asn Leu Ile Ala Phe Leu Ala Leu Leu Ser Phe Met 
    450                 455                 460                 


Asn Ser Ala Leu Ser Trp Phe Gly Asn Met Phe Asp Tyr Pro Gln Leu 
465                 470                 475                 480 


Ser Phe Glu Leu Ile Cys Ser Tyr Ile Phe Met Pro Phe Ser Phe Met 
                485                 490                 495     


Met Gly Val Glu Trp Gln Asp Ser Phe Met Val Ala Arg Leu Ile Gly 
            500                 505                 510         


Tyr Lys Thr Phe Phe Asn Glu Phe Val Ala Tyr Glu His Leu Ser Lys 
        515                 520                 525             


Trp Ile His Leu Arg Lys Glu Gly Gly Pro Lys Phe Val Asn Gly Val 
    530                 535                 540                 


Gln Gln Tyr Ile Ser Ile Arg Ser Glu Ile Ile Ala Thr Tyr Ala Leu 
545                 550                 555                 560 


Cys Gly Phe Ala Asn Ile Gly Ser Leu Gly Ile Val Ile Gly Gly Leu 
                565                 570                 575     


Thr Ser Met Ala Pro Ser Arg Lys Arg Asp Ile Ala Ser Gly Ala Val 
            580                 585                 590         


Arg Ala Leu Ile Ala Gly Thr Val Ala Cys Phe Met Thr Ala Cys Ile 
        595                 600                 605             


Ala Gly Ile Leu Ser Ser Thr Pro Val Asp Ile Asn Cys His His Val 
    610                 615                 620                 


Leu Glu Asn Ala Phe Asn Ser Thr Phe Pro Gly Asn Thr Thr Lys Val 
625                 630                 635                 640 


Ile Ala Cys Cys Gln Ser Leu Leu Ser Ser Thr Val Ala Lys Gly Pro 
                645                 650                 655     


Gly Glu Val Ile Pro Gly Gly Asn His Ser Leu Tyr Ser Leu Lys Gly 
            660                 665                 670         


Cys Cys Thr Leu Leu Asn Pro Ser Thr Phe Asn Cys Asn Gly Ile Ser 
        675                 680                 685             


Asn Thr Phe 
    690     


<210>  476
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  476

Met Glu Leu Arg Ser Thr Ala Ala Pro Arg Ala Glu Gly Tyr Ser Asn 
1               5                   10                  15      


Val Gly Phe Gln Asn Glu Glu Asn Phe Leu Glu Asn Glu Asn Thr Ser 
            20                  25                  30          


Gly Asn Asn Ser Ile Arg Ser Arg Ala Val Gln Ser Arg Glu His Thr 
        35                  40                  45              


Asn Thr Lys Gln Asp Glu Glu Gln Val Thr Val Glu Gln Asp Ser Pro 
    50                  55                  60                  


Arg Asn Arg Glu His Met Glu Asp Asp Asp Glu Glu Met Gln Gln Lys 
65                  70                  75                  80  


Gly Cys Leu Glu Arg Arg Tyr Asp Thr Val Cys Gly Phe Cys Arg Lys 
                85                  90                  95      


His Lys Thr Thr Leu Arg His Ile Ile Trp Gly Ile Leu Leu Ala Gly 
            100                 105                 110         


Tyr Leu Val Met Val Ile Ser Ala Cys Val Leu Asn Phe His Arg Ala 
        115                 120                 125             


Leu Pro Leu Phe Val Ile Thr Val Ala Ala Ile Phe Phe Val Val Trp 
    130                 135                 140                 


Asp His Leu Met Ala Lys Tyr Glu His Arg Ile Asp Glu Met Leu Ser 
145                 150                 155                 160 


Pro Gly Arg Arg Leu Leu Asn Ser His Trp Phe Trp Leu Lys Trp Val 
                165                 170                 175     


Ile Trp Ser Ser Leu Val Leu Ala Val Ile Phe Trp Leu Ala Phe Asp 
            180                 185                 190         


Thr Ala Lys Leu Gly Gln Gln Gln Leu Val Ser Phe Gly Gly Leu Ile 
        195                 200                 205             


Met Tyr Ile Val Leu Leu Phe Leu Phe Ser Lys Tyr Pro Thr Arg Val 
    210                 215                 220                 


Tyr Trp Arg Pro Val Leu Trp Gly Ile Gly Leu Gln Phe Leu Leu Gly 
225                 230                 235                 240 


Leu Leu Ile Leu Arg Thr Asp Pro Gly Phe Ile Ala Phe Asp Trp Leu 
                245                 250                 255     


Gly Arg Gln Val Gln Thr Phe Leu Glu Tyr Thr Asp Ala Gly Ala Ser 
            260                 265                 270         


Phe Val Phe Gly Glu Lys Tyr Lys Asp His Phe Phe Ala Phe Lys Val 
        275                 280                 285             


Leu Pro Ile Val Val Phe Phe Ser Thr Val Met Ser Met Leu Tyr Tyr 
    290                 295                 300                 


Leu Gly Leu Met Gln Trp Ile Ile Arg Lys Val Gly Trp Ile Met Leu 
305                 310                 315                 320 


Val Thr Thr Gly Ser Ser Pro Ile Glu Ser Val Val Ala Ser Gly Asn 
                325                 330                 335     


Ile Phe Val Gly Gln Thr Glu Ser Pro Leu Leu Val Arg Pro Tyr Leu 
            340                 345                 350         


Pro Tyr Ile Thr Lys Ser Glu Leu His Ala Ile Met Thr Ala Gly Phe 
        355                 360                 365             


Ser Thr Ile Ala Gly Ser Val Leu Gly Ala Tyr Ile Ser Phe Gly Val 
    370                 375                 380                 


Pro Ser Ser His Leu Leu Thr Ala Ser Val Met Ser Ala Pro Ala Ser 
385                 390                 395                 400 


Leu Ala Ala Ala Lys Leu Phe Trp Pro Glu Thr Glu Lys Pro Lys Ile 
                405                 410                 415     


Thr Leu Lys Asn Ala Met Lys Met Glu Ser Gly Asp Ser Gly Asn Leu 
            420                 425                 430         


Leu Glu Ala Ala Thr Gln Gly Ala Ser Ser Ser Ile Ser Leu Val Ala 
        435                 440                 445             


Asn Ile Ala Val Asn Leu Ile Ala Phe Leu Ala Leu Leu Ser Phe Met 
    450                 455                 460                 


Asn Ser Ala Leu Ser Trp Phe Gly Asn Met Phe Asp Tyr Pro Gln Leu 
465                 470                 475                 480 


Ser Phe Glu Leu Ile Cys Ser Tyr Ile Phe Met Pro Phe Ser Phe Met 
                485                 490                 495     


Met Gly Val Glu Trp Gln Asp Ser Phe Met Val Ala Arg Leu Ile Gly 
            500                 505                 510         


Tyr Lys Thr Phe Phe Asn Glu Phe Val Ala Tyr Glu His Leu Ser Lys 
        515                 520                 525             


Trp Ile His Leu Arg Lys Glu Gly Gly Pro Lys Phe Val Asn Gly Val 
    530                 535                 540                 


Gln Gln Tyr Ile Ser Ile Arg Ser Glu Ile Ile Ala Thr Tyr Ala Leu 
545                 550                 555                 560 


Cys Gly Phe Ala Asn Ile Gly Ser Leu Gly Ile Val Ile Gly Gly Leu 
                565                 570                 575     


Thr Ser Met Ala Pro Ser Arg Lys Arg Asp Ile Ala Ser Gly Ala Val 
            580                 585                 590         


Arg Ala Leu Ile Ala Gly Thr Val Ala Cys Phe Met Thr Ala Cys Ile 
        595                 600                 605             


Ala Gly Ile Leu Ser Ser Thr Pro Val Asp Ile Asn Cys His His Val 
    610                 615                 620                 


Leu Glu Asn Ala Phe Asn Ser Thr Phe Pro Gly Asn Thr Thr Lys Val 
625                 630                 635                 640 


Ile Ala Cys Cys Gln Ser Leu Leu Ser Ser Thr Val Ala Lys Gly Pro 
                645                 650                 655     


Gly Glu Val Ile Pro Gly Gly Asn His Ser Leu Tyr Ser Leu Lys Gly 
            660                 665                 670         


Cys Cys Thr Leu Leu Asn Pro Ser Thr Phe Asn Cys Asn Gly Ile Ser 
        675                 680                 685             


Asn Thr Phe 
    690     


<210>  477
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  477

Met Val Pro Val Glu Asn Thr Glu Gly Pro Ser Leu Leu Asn Gln Lys 
1               5                   10                  15      


Gly Thr Ala Val Glu Thr Glu Gly Ser Gly Ser Arg His Pro Pro Trp 
            20                  25                  30          


Ala Arg Gly Cys Gly Met Phe Thr Phe Leu Ser Ser Val Thr Ala Ala 
        35                  40                  45              


Val Ser Gly Leu Leu Val Gly Tyr Glu Leu Gly Ile Ile Ser Gly Ala 
    50                  55                  60                  


Leu Leu Gln Ile Lys Thr Leu Leu Ala Leu Ser Cys His Glu Gln Glu 
65                  70                  75                  80  


Met Val Val Ser Ser Leu Val Ile Gly Ala Leu Leu Ala Ser Leu Thr 
                85                  90                  95      


Gly Gly Val Leu Ile Asp Arg Tyr Gly Arg Arg Thr Ala Ile Ile Leu 
            100                 105                 110         


Ser Ser Cys Leu Leu Gly Leu Gly Ser Leu Val Leu Ile Leu Ser Leu 
        115                 120                 125             


Ser Tyr Thr Val Leu Ile Val Gly Arg Ile Ala Ile Gly Val Ser Ile 
    130                 135                 140                 


Ser Leu Ser Ser Ile Ala Thr Cys Val Tyr Ile Ala Glu Ile Ala Pro 
145                 150                 155                 160 


Gln His Arg Arg Gly Leu Leu Val Ser Leu Asn Glu Leu Met Ile Val 
                165                 170                 175     


Ile Gly Ile Leu Ser Ala Tyr Ile Ser Asn Tyr Ala Phe Ala Asn Val 
            180                 185                 190         


Phe His Gly Trp Lys Tyr Met Phe Gly Leu Val Ile Pro Leu Gly Val 
        195                 200                 205             


Leu Gln Ala Ile Ala Met Tyr Phe Leu Pro Pro Ser Pro Arg Phe Leu 
    210                 215                 220                 


Val Met Lys Gly Gln Glu Gly Ala Ala Ser Lys Val Leu Gly Arg Leu 
225                 230                 235                 240 


Arg Ala Leu Ser Asp Thr Thr Glu Glu Leu Thr Val Ile Lys Ser Ser 
                245                 250                 255     


Leu Lys Asp Glu Tyr Gln Tyr Ser Phe Trp Asp Leu Phe Arg Ser Lys 
            260                 265                 270         


Asp Asn Met Arg Thr Arg Ile Met Ile Gly Leu Thr Leu Val Phe Phe 
        275                 280                 285             


Val Gln Ile Thr Gly Gln Pro Asn Ile Leu Phe Tyr Ala Ser Thr Val 
    290                 295                 300                 


Leu Lys Ser Val Gly Phe Gln Ser Asn Glu Ala Ala Ser Leu Ala Ser 
305                 310                 315                 320 


Thr Gly Val Gly Val Val Lys Val Ile Ser Thr Ile Pro Ala Thr Leu 
                325                 330                 335     


Leu Val Asp His Val Gly Ser Lys Thr Phe Leu Cys Ile Gly Ser Ser 
            340                 345                 350         


Val Met Ala Ala Ser Leu Val Thr Met Gly Ile Val Asn Leu Asn Ile 
        355                 360                 365             


His Met Asn Phe Thr His Ile Cys Arg Ser His Asn Ser Ile Asn Gln 
    370                 375                 380                 


Ser Leu Asp Glu Ser Val Ile Tyr Gly Pro Gly Asn Leu Ser Thr Asn 
385                 390                 395                 400 


Asn Asn Thr Leu Arg Asp His Phe Lys Gly Ile Ser Ser His Ser Arg 
                405                 410                 415     


Ser Ser Leu Met Pro Leu Arg Asn Asp Val Asp Lys Arg Gly Glu Thr 
            420                 425                 430         


Thr Ser Ala Ser Leu Leu Asn Ala Gly Leu Ser His Thr Glu Tyr Gln 
        435                 440                 445             


Ile Val Thr Asp Pro Gly Asp Val Pro Ala Phe Leu Lys Trp Leu Ser 
    450                 455                 460                 


Leu Ala Ser Leu Leu Val Tyr Val Ala Ala Phe Ser Ile Gly Leu Gly 
465                 470                 475                 480 


Pro Met Pro Trp Leu Val Leu Ser Glu Ile Phe Pro Gly Gly Ile Arg 
                485                 490                 495     


Gly Arg Ala Met Ala Leu Thr Ser Ser Met Asn Trp Gly Ile Asn Leu 
            500                 505                 510         


Leu Ile Ser Leu Thr Phe Leu Thr Val Thr Asp Leu Ile Gly Leu Pro 
        515                 520                 525             


Trp Val Cys Phe Ile Tyr Thr Ile Met Ser Leu Ala Ser Leu Leu Phe 
    530                 535                 540                 


Val Val Met Phe Ile Pro Glu Thr Lys Gly Cys Ser Leu Glu Gln Ile 
545                 550                 555                 560 


Ser Met Glu Leu Ala Lys Val Asn Tyr Val Lys Asn Asn Ile Cys Phe 
                565                 570                 575     


Met Ser His His Gln Glu Glu Leu Val Pro Lys Gln Pro Gln Lys Arg 
            580                 585                 590         


Lys Pro Gln Glu Gln Leu Leu Glu Cys Asn Lys Leu Cys Gly Arg Gly 
        595                 600                 605             


Gln Ser Arg Gln Leu Ser Pro Glu Thr 
    610                 615         


<210>  478
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  478

Met Thr Glu Asp Lys Val Thr Gly Thr Leu Val Phe Thr Val Ile Thr 
1               5                   10                  15      


Ala Val Leu Gly Ser Phe Gln Phe Gly Tyr Asp Ile Gly Val Ile Asn 
            20                  25                  30          


Ala Pro Gln Gln Val Ile Ile Ser His Tyr Arg His Val Leu Gly Val 
        35                  40                  45              


Pro Leu Asp Asp Arg Lys Ala Ile Asn Asn Tyr Val Ile Asn Ser Thr 
    50                  55                  60                  


Asp Glu Leu Pro Thr Ile Ser Tyr Ser Met Asn Pro Lys Pro Thr Pro 
65                  70                  75                  80  


Trp Ala Glu Glu Glu Thr Val Ala Ala Ala Gln Leu Ile Thr Met Leu 
                85                  90                  95      


Trp Ser Leu Ser Val Ser Ser Phe Ala Val Gly Gly Met Thr Ala Ser 
            100                 105                 110         


Phe Phe Gly Gly Trp Leu Gly Asp Thr Leu Gly Arg Ile Lys Ala Met 
        115                 120                 125             


Leu Val Ala Asn Ile Leu Ser Leu Val Gly Ala Leu Leu Met Gly Phe 
    130                 135                 140                 


Ser Lys Leu Gly Pro Ser His Ile Leu Ile Ile Ala Gly Arg Ser Ile 
145                 150                 155                 160 


Ser Gly Leu Tyr Cys Gly Leu Ile Ser Gly Leu Val Pro Met Tyr Ile 
                165                 170                 175     


Gly Glu Ile Ala Pro Thr Ala Leu Arg Gly Ala Leu Gly Thr Phe His 
            180                 185                 190         


Gln Leu Ala Ile Val Thr Gly Ile Leu Ile Ser Gln Ile Ile Gly Leu 
        195                 200                 205             


Glu Phe Ile Leu Gly Asn Tyr Asp Leu Trp His Ile Leu Leu Gly Leu 
    210                 215                 220                 


Ser Gly Val Arg Ala Ile Leu Gln Ser Leu Leu Leu Phe Phe Cys Pro 
225                 230                 235                 240 


Glu Ser Pro Arg Tyr Leu Tyr Ile Lys Leu Asp Glu Glu Val Lys Ala 
                245                 250                 255     


Lys Gln Ser Leu Lys Arg Leu Arg Gly Tyr Asp Asp Val Thr Lys Asp 
            260                 265                 270         


Ile Asn Glu Met Arg Lys Glu Arg Glu Glu Ala Ser Ser Glu Gln Lys 
        275                 280                 285             


Val Ser Ile Ile Gln Leu Phe Thr Asn Ser Ser Tyr Arg Gln Pro Ile 
    290                 295                 300                 


Leu Val Ala Leu Met Leu His Val Ala Gln Gln Phe Ser Gly Ile Asn 
305                 310                 315                 320 


Gly Ile Phe Tyr Tyr Ser Thr Ser Ile Phe Gln Thr Ala Gly Ile Ser 
                325                 330                 335     


Lys Pro Val Tyr Ala Thr Ile Gly Val Gly Ala Val Asn Met Val Phe 
            340                 345                 350         


Thr Ala Val Ser Val Phe Leu Val Glu Lys Ala Gly Arg Arg Ser Leu 
        355                 360                 365             


Phe Leu Ile Gly Met Ser Gly Met Phe Val Cys Ala Ile Phe Met Ser 
    370                 375                 380                 


Val Gly Leu Val Leu Leu Asn Lys Phe Ser Trp Met Ser Tyr Val Ser 
385                 390                 395                 400 


Met Ile Ala Ile Phe Leu Phe Val Ser Phe Phe Glu Ile Gly Pro Gly 
                405                 410                 415     


Pro Ile Pro Trp Phe Met Val Ala Glu Phe Phe Ser Gln Gly Pro Arg 
            420                 425                 430         


Pro Ala Ala Leu Ala Ile Ala Ala Phe Ser Asn Trp Thr Cys Asn Phe 
        435                 440                 445             


Ile Val Ala Leu Cys Phe Gln Tyr Ile Ala Asp Phe Cys Gly Pro Tyr 
    450                 455                 460                 


Val Phe Phe Leu Phe Ala Gly Val Leu Leu Ala Phe Thr Leu Phe Thr 
465                 470                 475                 480 


Phe Phe Lys Val Pro Glu Thr Lys Gly Lys Ser Phe Glu Glu Ile Ala 
                485                 490                 495     


Ala Glu Phe Gln Lys Lys Ser Gly Ser Ala His Arg Pro Lys Ala Ala 
            500                 505                 510         


Val Glu Met Lys Phe Leu Gly Ala Thr Glu Thr Val 
        515                 520                 


<210>  479
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  479

Met His Leu Asn Arg Ile Lys Ala Met Leu Val Ala Asn Ile Leu Ser 
1               5                   10                  15      


Leu Val Gly Ala Leu Leu Met Gly Phe Ser Lys Leu Gly Pro Ser His 
            20                  25                  30          


Ile Leu Ile Ile Ala Gly Arg Ser Ile Ser Gly Leu Tyr Cys Gly Leu 
        35                  40                  45              


Ile Ser Gly Leu Val Pro Met Tyr Ile Gly Glu Ile Ala Pro Thr Ala 
    50                  55                  60                  


Leu Arg Gly Ala Leu Gly Thr Phe His Gln Leu Ala Ile Val Thr Gly 
65                  70                  75                  80  


Ile Leu Ile Ser Gln Ile Ile Gly Leu Glu Phe Ile Leu Gly Asn Tyr 
                85                  90                  95      


Asp Leu Trp His Ile Leu Leu Gly Leu Ser Gly Val Arg Ala Ile Leu 
            100                 105                 110         


Gln Ser Leu Leu Leu Phe Phe Cys Pro Glu Ser Pro Arg Tyr Leu Tyr 
        115                 120                 125             


Ile Lys Leu Asp Glu Glu Val Lys Ala Lys Gln Ser Leu Lys Arg Leu 
    130                 135                 140                 


Arg Gly Tyr Asp Asp Val Thr Lys Asp Ile Asn Glu Met Arg Lys Glu 
145                 150                 155                 160 


Arg Glu Glu Ala Ser Ser Glu Gln Lys Val Ser Ile Ile Gln Leu Phe 
                165                 170                 175     


Thr Asn Ser Ser Tyr Arg Gln Pro Ile Leu Val Ala Leu Met Leu His 
            180                 185                 190         


Val Ala Gln Gln Phe Ser Gly Ile Asn Gly Ile Phe Tyr Tyr Ser Thr 
        195                 200                 205             


Ser Ile Phe Gln Thr Ala Gly Ile Ser Lys Pro Val Tyr Ala Thr Ile 
    210                 215                 220                 


Gly Val Gly Ala Val Asn Met Val Phe Thr Ala Val Ser Val Phe Leu 
225                 230                 235                 240 


Val Glu Lys Ala Gly Arg Arg Ser Leu Phe Leu Ile Gly Met Ser Gly 
                245                 250                 255     


Met Phe Val Cys Ala Ile Phe Met Ser Val Gly Leu Val Leu Leu Asn 
            260                 265                 270         


Lys Phe Ser Trp Met Ser Tyr Val Ser Met Ile Ala Ile Phe Leu Phe 
        275                 280                 285             


Val Ser Phe Phe Glu Ile Gly Pro Gly Pro Ile Pro Trp Phe Met Val 
    290                 295                 300                 


Ala Glu Phe Phe Ser Gln Gly Pro Arg Pro Ala Ala Leu Ala Ile Ala 
305                 310                 315                 320 


Ala Phe Ser Asn Trp Thr Cys Asn Phe Ile Val Ala Leu Cys Phe Gln 
                325                 330                 335     


Tyr Ile Ala Asp Phe Cys Gly Pro Tyr Val Phe Phe Leu Phe Ala Gly 
            340                 345                 350         


Val Leu Leu Ala Phe Thr Leu Phe Thr Phe Phe Lys Val Pro Glu Thr 
        355                 360                 365             


Lys Gly Lys Ser Phe Glu Glu Ile Ala Ala Glu Phe Gln Lys Lys Ser 
    370                 375                 380                 


Gly Ser Ala His Arg Pro Lys Ala Ala Val Glu Met Lys Phe Leu Gly 
385                 390                 395                 400 


Ala Thr Glu Thr Val 
                405 


<210>  480
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  480

Met Tyr Ile Gly Glu Ile Ala Pro Thr Ala Leu Arg Gly Ala Leu Gly 
1               5                   10                  15      


Thr Phe His Gln Leu Ala Ile Val Thr Gly Ile Leu Ile Ser Gln Ile 
            20                  25                  30          


Ile Gly Leu Glu Phe Ile Leu Gly Asn Tyr Asp Leu Trp His Ile Leu 
        35                  40                  45              


Leu Gly Leu Ser Gly Val Arg Ala Ile Leu Gln Ser Leu Leu Leu Phe 
    50                  55                  60                  


Phe Cys Pro Glu Ser Pro Arg Tyr Leu Tyr Ile Lys Leu Asp Glu Glu 
65                  70                  75                  80  


Val Lys Ala Lys Gln Ser Leu Lys Arg Leu Arg Gly Tyr Asp Asp Val 
                85                  90                  95      


Thr Lys Asp Ile Asn Glu Met Arg Lys Glu Arg Glu Glu Ala Ser Ser 
            100                 105                 110         


Glu Gln Lys Val Ser Ile Ile Gln Leu Phe Thr Asn Ser Ser Tyr Arg 
        115                 120                 125             


Gln Pro Ile Leu Val Ala Leu Met Leu His Val Ala Gln Gln Phe Ser 
    130                 135                 140                 


Gly Ile Asn Gly Ile Phe Tyr Tyr Ser Thr Ser Ile Phe Gln Thr Ala 
145                 150                 155                 160 


Gly Ile Ser Lys Pro Val Tyr Ala Thr Ile Gly Val Gly Ala Val Asn 
                165                 170                 175     


Met Val Phe Thr Ala Val Ser Val Phe Leu Val Glu Lys Ala Gly Arg 
            180                 185                 190         


Arg Ser Leu Phe Leu Ile Gly Met Ser Gly Met Phe Val Cys Ala Ile 
        195                 200                 205             


Phe Met Ser Val Gly Leu Val Leu Leu Asn Lys Phe Ser Trp Met Ser 
    210                 215                 220                 


Tyr Val Ser Met Ile Ala Ile Phe Leu Phe Val Ser Phe Phe Glu Ile 
225                 230                 235                 240 


Gly Pro Gly Pro Ile Pro Trp Phe Met Val Ala Glu Phe Phe Ser Gln 
                245                 250                 255     


Gly Pro Arg Pro Ala Ala Leu Ala Ile Ala Ala Phe Ser Asn Trp Thr 
            260                 265                 270         


Cys Asn Phe Ile Val Ala Leu Cys Phe Gln Tyr Ile Ala Asp Phe Cys 
        275                 280                 285             


Gly Pro Tyr Val Phe Phe Leu Phe Ala Gly Val Leu Leu Ala Phe Thr 
    290                 295                 300                 


Leu Phe Thr Phe Phe Lys Val Pro Glu Thr Lys Gly Lys Ser Phe Glu 
305                 310                 315                 320 


Glu Ile Ala Ala Glu Phe Gln Lys Lys Ser Gly Ser Ala His Arg Pro 
                325                 330                 335     


Lys Ala Ala Val Glu Met Lys Phe Leu Gly Ala Thr Glu Thr Val 
            340                 345                 350     


<210>  481
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  481

Met Gly Arg Tyr Ser Gly Lys Thr Cys Arg Leu Leu Phe Met Leu Val 
1               5                   10                  15      


Leu Thr Val Ala Phe Phe Val Ala Glu Leu Val Ser Gly Tyr Leu Gly 
            20                  25                  30          


Asn Ser Ile Ala Leu Leu Ser Asp Ser Phe Asn Met Leu Ser Asp Leu 
        35                  40                  45              


Ile Ser Leu Cys Val Gly Leu Ser Ala Gly Tyr Ile Ala Arg Arg Pro 
    50                  55                  60                  


Thr Arg Gly Phe Ser Ala Thr Tyr Gly Tyr Ala Arg Ala Glu Val Val 
65                  70                  75                  80  


Gly Ala Leu Ser Asn Ala Val Phe Leu Thr Ala Leu Cys Phe Thr Ile 
                85                  90                  95      


Phe Val Glu Ala Val Leu Arg Leu Ala Arg Pro Glu Arg Ile Asp Asp 
            100                 105                 110         


Pro Glu Leu Val Leu Ile Val Gly Val Leu Gly Leu Leu Val Asn Val 
        115                 120                 125             


Val Gly Leu Leu Ile Phe Gln Asp Cys Ala Ala Trp Phe Ala Cys Cys 
    130                 135                 140                 


Leu Arg Gly Arg Ser Arg Arg Leu Gln Gln Arg Gln Gln Leu Ala Glu 
145                 150                 155                 160 


Gly Cys Val Pro Gly Ala Phe Gly Gly Pro Gln Gly Ala Glu Asp Pro 
                165                 170                 175     


Arg Arg Ala Ala Asp Pro Thr Ala Pro Gly Ser Asp Ser Ala Val Thr 
            180                 185                 190         


Leu Arg Gly Thr Ser Val Glu Arg Lys Arg Glu Lys Gly Ala Thr Val 
        195                 200                 205             


Phe Ala Asn Val Ala Gly Asp Ser Phe Asn Thr Gln Asn Glu Pro Glu 
    210                 215                 220                 


Asp Met Met Lys Lys Glu Lys Lys Ser Glu Ala Leu Asn Ile Arg Gly 
225                 230                 235                 240 


Val Leu Leu His Val Met Gly Asp Ala Leu Gly Ser Val Val Val Val 
                245                 250                 255     


Ile Thr Ala Ile Ile Phe Tyr Val Leu Pro Leu Lys Ser Glu Asp Pro 
            260                 265                 270         


Cys Asn Trp Gln Cys Tyr Ile Asp Pro Ser Leu Thr Val Leu Met Val 
        275                 280                 285             


Ile Ile Ile Leu Ser Ser Ala Phe Pro Leu Ile Lys Glu Thr Ala Ala 
    290                 295                 300                 


Ile Leu Leu Gln Met Val Pro Lys Gly Val Asn Met Glu Glu Leu Met 
305                 310                 315                 320 


Ser Lys Leu Ser Ala Val Pro Gly Ile Ser Ser Val His Glu Val His 
                325                 330                 335     


Ile Trp Glu Leu Val Ser Gly Lys Ile Ile Ala Thr Leu His Ile Lys 
            340                 345                 350         


Tyr Pro Lys Asp Arg Gly Tyr Gln Asp Ala Ser Thr Lys Ile Arg Glu 
        355                 360                 365             


Ile Phe His His Ala Gly Ile His Asn Val Thr Ile Gln Phe Glu Asn 
    370                 375                 380                 


Val Asp Leu Lys Glu Pro Leu Glu Gln Lys Asp Leu Leu Leu Leu Cys 
385                 390                 395                 400 


Asn Ser Pro Cys Ile Ser Lys Gly Cys Ala Lys Gln Leu Cys Cys Pro 
                405                 410                 415     


Pro Gly Ala Leu Pro Leu Ala His Val Asn Gly Cys Ala Glu His Asn 
            420                 425                 430         


Gly Gly Pro Ser Leu Asp Thr Tyr Gly Ser Asp Gly Leu Ser Arg Arg 
        435                 440                 445             


Asp Ala Arg Glu Val Ala Ile Glu Val Ser Leu Asp Ser Cys Leu Ser 
    450                 455                 460                 


Asp His Gly Gln Ser Leu Asn Lys Thr Gln Glu Asp Gln Cys Tyr Val 
465                 470                 475                 480 


Asn Arg Thr His Phe 
                485 


<210>  482
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  482

Met Met His Phe Lys Ser Gly Leu Glu Leu Thr Glu Leu Gln Asn Met 
1               5                   10                  15      


Thr Val Pro Glu Asp Asp Asn Ile Ser Asn Asp Ser Asn Asp Phe Thr 
            20                  25                  30          


Glu Val Glu Asn Gly Gln Ile Asn Ser Lys Phe Ile Ser Asp Arg Glu 
        35                  40                  45              


Ser Arg Arg Ser Leu Thr Asn Ser His Leu Glu Lys Lys Lys Cys Asp 
    50                  55                  60                  


Glu Tyr Ile Pro Gly Thr Thr Ser Leu Gly Met Ser Val Phe Asn Leu 
65                  70                  75                  80  


Ser Asn Ala Ile Met Gly Ser Gly Ile Leu Gly Leu Ala Phe Ala Leu 
                85                  90                  95      


Ala Asn Thr Gly Ile Leu Leu Phe Leu Val Leu Leu Thr Ser Val Thr 
            100                 105                 110         


Leu Leu Ser Ile Tyr Ser Ile Asn Leu Leu Leu Ile Cys Ser Lys Glu 
        115                 120                 125             


Thr Gly Cys Met Val Tyr Glu Lys Leu Gly Glu Gln Val Phe Gly Thr 
    130                 135                 140                 


Thr Gly Lys Phe Val Ile Phe Gly Ala Thr Ser Leu Gln Asn Thr Gly 
145                 150                 155                 160 


Ala Met Leu Ser Tyr Leu Phe Ile Val Lys Asn Glu Leu Pro Ser Ala 
                165                 170                 175     


Ile Lys Phe Leu Met Gly Lys Glu Glu Thr Phe Ser Ala Trp Tyr Val 
            180                 185                 190         


Asp Gly Arg Val Leu Val Val Ile Val Thr Phe Gly Ile Ile Leu Pro 
        195                 200                 205             


Leu Cys Leu Leu Lys Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Phe 
    210                 215                 220                 


Ser Leu Ser Cys Met Val Phe Phe Leu Ile Val Val Ile Tyr Lys Lys 
225                 230                 235                 240 


Phe Gln Ile Pro Cys Ile Val Pro Glu Leu Asn Ser Thr Ile Ser Ala 
                245                 250                 255     


Asn Ser Thr Asn Ala Asp Thr Cys Thr Pro Lys Tyr Val Thr Phe Asn 
            260                 265                 270         


Ser Lys Thr Val Tyr Ala Leu Pro Thr Ile Ala Phe Ala Phe Val Cys 
        275                 280                 285             


His Pro Ser Val Leu Pro Ile Tyr Ser Glu Leu Lys Asp Arg Ser Gln 
    290                 295                 300                 


Lys Lys Met Gln Met Val Ser Asn Ile Ser Phe Phe Ala Met Phe Val 
305                 310                 315                 320 


Met Tyr Phe Leu Thr Ala Ile Phe Gly Tyr Leu Thr Phe Tyr Asp Asn 
                325                 330                 335     


Val Gln Ser Asp Leu Leu His Lys Tyr Gln Ser Lys Asp Asp Ile Leu 
            340                 345                 350         


Ile Leu Thr Val Arg Leu Ala Val Ile Val Ala Val Ile Leu Thr Val 
        355                 360                 365             


Pro Val Leu Phe Phe Thr Val Arg Ser Ser Leu Phe Glu Leu Ala Lys 
    370                 375                 380                 


Lys Thr Lys Phe Asn Leu Cys Arg His Thr Val Val Thr Cys Ile Leu 
385                 390                 395                 400 


Leu Val Val Ile Asn Leu Leu Val Ile Phe Ile Pro Ser Met Lys Asp 
                405                 410                 415     


Ile Phe Gly Val Val Gly Val Thr Ser Ala Asn Met Leu Ile Phe Ile 
            420                 425                 430         


Leu Pro Ser Ser Leu Tyr Leu Lys Ile Thr Asp Gln Asp Gly Asp Lys 
        435                 440                 445             


Gly Thr Gln Arg Ile Trp Ala Ala Leu Phe Leu Gly Leu Gly Val Leu 
    450                 455                 460                 


Phe Ser Leu Val Ser Ile Pro Leu Val Ile Tyr Asp Trp Ala Cys Ser 
465                 470                 475                 480 


Ser Ser Ser Asp Glu Gly His 
                485         


<210>  483
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  483

Met Met His Phe Lys Ser Gly Leu Glu Leu Thr Glu Leu Gln Asn Met 
1               5                   10                  15      


Thr Val Pro Glu Asp Asp Asn Ile Ser Asn Asp Ser Asn Asp Phe Thr 
            20                  25                  30          


Glu Val Glu Asn Gly Gln Ile Asn Ser Lys Phe Ile Ser Asp Arg Glu 
        35                  40                  45              


Ser Arg Arg Ser Leu Thr Asn Ser His Leu Glu Lys Lys Lys Cys Asp 
    50                  55                  60                  


Glu Tyr Ile Pro Gly Thr Thr Ser Leu Gly Met Ser Val Phe Asn Leu 
65                  70                  75                  80  


Ser Asn Ala Ile Met Gly Ser Gly Ile Leu Gly Leu Ala Phe Ala Leu 
                85                  90                  95      


Ala Asn Thr Gly Ile Leu Leu Phe Leu Val Leu Leu Thr Ser Val Thr 
            100                 105                 110         


Leu Leu Ser Ile Tyr Ser Ile Asn Leu Leu Leu Ile Cys Ser Lys Glu 
        115                 120                 125             


Thr Gly Cys Met Val Tyr Glu Lys Leu Gly Glu Gln Val Phe Gly Thr 
    130                 135                 140                 


Thr Gly Lys Phe Val Ile Phe Gly Ala Thr Ser Leu Gln Asn Thr Gly 
145                 150                 155                 160 


Ala Met Leu Ser Tyr Leu Phe Ile Val Lys Asn Glu Leu Pro Ser Ala 
                165                 170                 175     


Ile Lys Phe Leu Met Gly Lys Glu Glu Thr Phe Ser Ala Trp Tyr Val 
            180                 185                 190         


Asp Gly Arg Val Leu Val Val Ile Val Thr Phe Gly Ile Ile Leu Pro 
        195                 200                 205             


Leu Cys Leu Leu Lys Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Phe 
    210                 215                 220                 


Ser Leu Ser Cys Met Val Phe Phe Leu Ile Val Val Ile Tyr Lys Lys 
225                 230                 235                 240 


Phe Gln Ile Pro Cys Ile Val Pro Glu Leu Asn Ser Thr Ile Ser Ala 
                245                 250                 255     


Asn Ser Thr Asn Ala Asp Thr Cys Thr Pro Lys Tyr Val Thr Phe Asn 
            260                 265                 270         


Ser Lys Thr Val Tyr Ala Leu Pro Thr Ile Ala Phe Ala Phe Val Cys 
        275                 280                 285             


His Pro Ser Val Leu Pro Ile Tyr Ser Glu Leu Lys Asp Arg Ser Gln 
    290                 295                 300                 


Lys Lys Met Gln Met Val Ser Asn Ile Ser Phe Phe Ala Met Phe Val 
305                 310                 315                 320 


Met Tyr Phe Leu Thr Ala Ile Phe Gly Tyr Leu Thr Phe Tyr Asp Asn 
                325                 330                 335     


Val Gln Ser Asp Leu Leu His Lys Tyr Gln Ser Lys Asp Asp Ile Leu 
            340                 345                 350         


Ile Leu Thr Val Arg Leu Ala Val Ile Val Ala Val Ile Leu Thr Val 
        355                 360                 365             


Pro Val Leu Phe Phe Thr Val Arg Ser Ser Leu Phe Glu Leu Ala Lys 
    370                 375                 380                 


Lys Thr Lys Phe Asn Leu Cys Arg His Thr Val Val Thr Cys Ile Leu 
385                 390                 395                 400 


Leu Val Val Ile Asn Leu Leu Val Ile Phe Ile Pro Ser Met Lys Asp 
                405                 410                 415     


Ile Phe Gly Val Val Gly Val Thr Ser Ala Asn Met Leu Ile Phe Ile 
            420                 425                 430         


Leu Pro Ser Ser Leu Tyr Leu Lys Ile Thr Asp Gln Asp Gly Asp Lys 
        435                 440                 445             


Gly Thr Gln Arg Ile Trp Ala Ala Leu Phe Leu Gly Leu Gly Val Leu 
    450                 455                 460                 


Phe Ser Leu Val Ser Ile Pro Leu Val Ile Tyr Asp Trp Ala Cys Ser 
465                 470                 475                 480 


Ser Ser Ser Asp Glu Gly His 
                485         


<210>  484
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  484

Met Met His Phe Lys Ser Gly Leu Glu Leu Thr Glu Leu Gln Asn Met 
1               5                   10                  15      


Thr Val Pro Glu Asp Asp Asn Ile Ser Asn Asp Ser Asn Asp Phe Thr 
            20                  25                  30          


Glu Val Glu Asn Gly Gln Ile Asn Ser Lys Phe Ile Ser Asp Arg Glu 
        35                  40                  45              


Ser Arg Arg Ser Leu Thr Asn Ser His Leu Glu Lys Lys Lys Cys Asp 
    50                  55                  60                  


Glu Tyr Ile Pro Gly Thr Thr Ser Leu Gly Met Ser Val Phe Asn Leu 
65                  70                  75                  80  


Ser Asn Ala Ile Met Gly Ser Gly Ile Leu Gly Leu Ala Phe Ala Leu 
                85                  90                  95      


Ala Asn Thr Gly Ile Leu Leu Phe Leu Val Leu Leu Thr Ser Val Thr 
            100                 105                 110         


Leu Leu Ser Ile Tyr Ser Ile Asn Leu Leu Leu Ile Cys Ser Lys Glu 
        115                 120                 125             


Thr Gly Cys Met Val Tyr Glu Lys Leu Gly Glu Gln Val Phe Gly Thr 
    130                 135                 140                 


Thr Gly Lys Phe Val Ile Phe Gly Ala Thr Ser Leu Gln Asn Thr Gly 
145                 150                 155                 160 


Ala Met Leu Ser Tyr Leu Phe Ile Val Lys Asn Glu Leu Pro Ser Ala 
                165                 170                 175     


Ile Lys Phe Leu Met Gly Lys Glu Glu Thr Phe Ser Ala Trp Tyr Val 
            180                 185                 190         


Asp Gly Arg Val Leu Val Val Ile Val Thr Phe Gly Ile Ile Leu Pro 
        195                 200                 205             


Leu Cys Leu Leu Lys Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Phe 
    210                 215                 220                 


Ser Leu Ser Cys Met Val Phe Phe Leu Ile Val Val Ile Tyr Lys Lys 
225                 230                 235                 240 


Phe Gln Ile Pro Cys Ile Val Pro Glu Leu Asn Ser Thr Ile Ser Ala 
                245                 250                 255     


Asn Ser Thr Asn Ala Asp Thr Cys Thr Pro Lys Tyr Val Thr Phe Asn 
            260                 265                 270         


Ser Lys Thr Val Tyr Ala Leu Pro Thr Ile Ala Phe Ala Phe Val Cys 
        275                 280                 285             


His Pro Ser Val Leu Pro Ile Tyr Ser Glu Leu Lys Asp Arg Ser Gln 
    290                 295                 300                 


Lys Lys Met Gln Met Val Ser Asn Ile Ser Phe Phe Ala Met Phe Val 
305                 310                 315                 320 


Met Tyr Phe Leu Thr Ala Ile Phe Gly Tyr Leu Thr Phe Tyr Asp Asn 
                325                 330                 335     


Val Gln Ser Asp Leu Leu His Lys Tyr Gln Ser Lys Asp Asp Ile Leu 
            340                 345                 350         


Ile Leu Thr Val Arg Leu Ala Val Ile Val Ala Val Ile Leu Thr Val 
        355                 360                 365             


Pro Val Leu Phe Phe Thr Val Arg Ser Ser Leu Phe Glu Leu Ala Lys 
    370                 375                 380                 


Lys Thr Lys Phe Asn Leu Cys Arg His Thr Val Val Thr Cys Ile Leu 
385                 390                 395                 400 


Leu Val Val Ile Asn Leu Leu Val Ile Phe Ile Pro Ser Met Lys Asp 
                405                 410                 415     


Ile Phe Gly Val Val Gly Val Thr Ser Ala Asn Met Leu Ile Phe Ile 
            420                 425                 430         


Leu Pro Ser Ser Leu Tyr Leu Lys Ile Thr Asp Gln Asp Gly Asp Lys 
        435                 440                 445             


Gly Thr Gln Arg Ile Trp Ala Ala Leu Phe Leu Gly Leu Gly Val Leu 
    450                 455                 460                 


Phe Ser Leu Val Ser Ile Pro Leu Val Ile Tyr Asp Trp Ala Cys Ser 
465                 470                 475                 480 


Ser Ser Ser Asp Glu Gly His 
                485         


<210>  485
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  485

Met Met His Phe Lys Ser Gly Leu Glu Leu Thr Glu Leu Gln Asn Met 
1               5                   10                  15      


Thr Val Pro Glu Asp Asp Asn Ile Ser Asn Asp Ser Asn Asp Phe Thr 
            20                  25                  30          


Glu Val Glu Asn Gly Gln Ile Asn Ser Lys Phe Ile Ser Asp Arg Glu 
        35                  40                  45              


Ser Arg Arg Ser Leu Thr Asn Ser His Leu Glu Lys Lys Lys Cys Asp 
    50                  55                  60                  


Glu Tyr Ile Pro Gly Thr Thr Ser Leu Gly Met Ser Val Phe Asn Leu 
65                  70                  75                  80  


Ser Asn Ala Ile Met Gly Ser Gly Ile Leu Gly Leu Ala Phe Ala Leu 
                85                  90                  95      


Ala Asn Thr Gly Ile Leu Leu Phe Leu Val Leu Leu Thr Ser Val Thr 
            100                 105                 110         


Leu Leu Ser Ile Tyr Ser Ile Asn Leu Leu Leu Ile Cys Ser Lys Glu 
        115                 120                 125             


Thr Gly Cys Met Val Tyr Glu Lys Leu Gly Glu Gln Val Phe Gly Thr 
    130                 135                 140                 


Thr Gly Lys Phe Val Ile Phe Gly Ala Thr Ser Leu Gln Asn Thr Gly 
145                 150                 155                 160 


Ala Met Leu Ser Tyr Leu Phe Ile Val Lys Asn Glu Leu Pro Ser Ala 
                165                 170                 175     


Ile Lys Phe Leu Met Gly Lys Glu Glu Thr Phe Ser Ala Trp Tyr Val 
            180                 185                 190         


Asp Gly Arg Val Leu Val Val Ile Val Thr Phe Gly Ile Ile Leu Pro 
        195                 200                 205             


Leu Cys Leu Leu Lys Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Phe 
    210                 215                 220                 


Ser Leu Ser Cys Met Val Phe Phe Leu Ile Val Val Ile Tyr Lys Lys 
225                 230                 235                 240 


Phe Gln Ile Pro Cys Ile Val Pro Glu Leu Asn Ser Thr Ile Ser Ala 
                245                 250                 255     


Asn Ser Thr Asn Ala Asp Thr Cys Thr Pro Lys Tyr Val Thr Phe Asn 
            260                 265                 270         


Ser Lys Thr Val Tyr Ala Leu Pro Thr Ile Ala Phe Ala Phe Val Cys 
        275                 280                 285             


His Pro Ser Val Leu Pro Ile Tyr Ser Glu Leu Lys Asp Arg Ser Gln 
    290                 295                 300                 


Lys Lys Met Gln Met Val Ser Asn Ile Ser Phe Phe Ala Met Phe Val 
305                 310                 315                 320 


Met Tyr Phe Leu Thr Ala Ile Phe Gly Tyr Leu Thr Phe Tyr Asp Asn 
                325                 330                 335     


Val Gln Ser Asp Leu Leu His Lys Tyr Gln Ser Lys Asp Asp Ile Leu 
            340                 345                 350         


Ile Leu Thr Val Arg Leu Ala Val Ile Val Ala Val Ile Leu Thr Val 
        355                 360                 365             


Pro Val Leu Phe Phe Thr Val Arg Ser Ser Leu Phe Glu Leu Ala Lys 
    370                 375                 380                 


Lys Thr Lys Phe Asn Leu Cys Arg His Thr Val Val Thr Cys Ile Leu 
385                 390                 395                 400 


Leu Val Val Ile Asn Leu Leu Val Ile Phe Ile Pro Ser Met Lys Asp 
                405                 410                 415     


Ile Phe Gly Val Val Gly Val Thr Ser Ala Asn Met Leu Ile Phe Ile 
            420                 425                 430         


Leu Pro Ser Ser Leu Tyr Leu Lys Ile Thr Asp Gln Asp Gly Asp Lys 
        435                 440                 445             


Gly Thr Gln Arg Ile Trp Ala Ala Leu Phe Leu Gly Leu Gly Val Leu 
    450                 455                 460                 


Phe Ser Leu Val Ser Ile Pro Leu Val Ile Tyr Asp Trp Ala Cys Ser 
465                 470                 475                 480 


Ser Ser Ser Asp Glu Gly His 
                485         


<210>  486
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  486

Met Met His Phe Lys Ser Gly Leu Glu Leu Thr Glu Leu Gln Asn Met 
1               5                   10                  15      


Thr Val Pro Glu Asp Asp Asn Ile Ser Asn Asp Ser Asn Asp Phe Thr 
            20                  25                  30          


Glu Val Glu Asn Gly Gln Ile Asn Ser Lys Phe Ile Ser Asp Arg Glu 
        35                  40                  45              


Ser Arg Arg Ser Leu Thr Asn Ser His Leu Glu Lys Lys Lys Cys Asp 
    50                  55                  60                  


Glu Tyr Ile Pro Gly Thr Thr Ser Leu Gly Met Ser Val Phe Asn Leu 
65                  70                  75                  80  


Ser Asn Ala Ile Met Gly Ser Gly Ile Leu Gly Leu Ala Phe Ala Leu 
                85                  90                  95      


Ala Asn Thr Gly Ile Leu Leu Phe Leu Val Leu Leu Thr Ser Val Thr 
            100                 105                 110         


Leu Leu Ser Ile Tyr Ser Ile Asn Leu Leu Leu Ile Cys Ser Lys Glu 
        115                 120                 125             


Thr Gly Cys Met Val Tyr Glu Lys Leu Gly Glu Gln Val Phe Gly Thr 
    130                 135                 140                 


Thr Gly Lys Phe Val Ile Phe Gly Ala Thr Ser Leu Gln Asn Thr Gly 
145                 150                 155                 160 


Ala Met Leu Ser Tyr Leu Phe Ile Val Lys Asn Glu Leu Pro Ser Ala 
                165                 170                 175     


Ile Lys Phe Leu Met Gly Lys Glu Glu Thr Phe Ser Ala Trp Tyr Val 
            180                 185                 190         


Asp Gly Arg Val Leu Val Val Ile Val Thr Phe Gly Ile Ile Leu Pro 
        195                 200                 205             


Leu Cys Leu Leu Lys Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Phe 
    210                 215                 220                 


Ser Leu Ser Cys Met Val Phe Phe Leu Ile Val Val Ile Tyr Lys Lys 
225                 230                 235                 240 


Phe Gln Ile Pro Cys Ile Val Pro Glu Leu Asn Ser Thr Ile Ser Ala 
                245                 250                 255     


Asn Ser Thr Asn Ala Asp Thr Cys Thr Pro Lys Tyr Val Thr Phe Asn 
            260                 265                 270         


Ser Lys Thr Val Tyr Ala Leu Pro Thr Ile Ala Phe Ala Phe Val Cys 
        275                 280                 285             


His Pro Ser Val Leu Pro Ile Tyr Ser Glu Leu Lys Asp Arg Ser Gln 
    290                 295                 300                 


Lys Lys Met Gln Met Val Ser Asn Ile Ser Phe Phe Ala Met Phe Val 
305                 310                 315                 320 


Met Tyr Phe Leu Thr Ala Ile Phe Gly Tyr Leu Thr Phe Tyr Asp Asn 
                325                 330                 335     


Val Gln Ser Asp Leu Leu His Lys Tyr Gln Ser Lys Asp Asp Ile Leu 
            340                 345                 350         


Ile Leu Thr Val Arg Leu Ala Val Ile Val Ala Val Ile Leu Thr Val 
        355                 360                 365             


Pro Val Leu Phe Phe Thr Val Arg Ser Ser Leu Phe Glu Leu Ala Lys 
    370                 375                 380                 


Lys Thr Lys Phe Asn Leu Cys Arg His Thr Val Val Thr Cys Ile Leu 
385                 390                 395                 400 


Leu Val Val Ile Asn Leu Leu Val Ile Phe Ile Pro Ser Met Lys Asp 
                405                 410                 415     


Ile Phe Gly Val Val Gly Val Thr Ser Ala Asn Met Leu Ile Phe Ile 
            420                 425                 430         


Leu Pro Ser Ser Leu Tyr Leu Lys Ile Thr Asp Gln Asp Gly Asp Lys 
        435                 440                 445             


Gly Thr Gln Arg Ile Trp Ala Ala Leu Phe Leu Gly Leu Gly Val Leu 
    450                 455                 460                 


Phe Ser Leu Val Ser Ile Pro Leu Val Ile Tyr Asp Trp Ala Cys Ser 
465                 470                 475                 480 


Ser Ser Ser Asp Glu Gly His 
                485         


<210>  487
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  487

Met Glu Ala Ser Trp Gly Ser Phe Asn Ala Glu Arg Gly Trp Tyr Val 
1               5                   10                  15      


Ser Val Gln Gln Pro Glu Glu Ala Glu Ala Glu Glu Leu Ser Pro Leu 
            20                  25                  30          


Leu Ser Asn Glu Leu His Arg Gln Arg Ser Pro Gly Val Ser Phe Gly 
        35                  40                  45              


Leu Ser Val Phe Asn Leu Met Asn Ala Ile Met Gly Ser Gly Ile Leu 
    50                  55                  60                  


Gly Leu Ala Tyr Val Leu Ala Asn Thr Gly Val Phe Gly Phe Ser Phe 
65                  70                  75                  80  


Leu Leu Leu Thr Val Ala Leu Leu Ala Ser Tyr Ser Val His Leu Leu 
                85                  90                  95      


Leu Ser Met Cys Ile Gln Thr Ala Val Thr Ser Tyr Glu Asp Leu Gly 
            100                 105                 110         


Leu Phe Ala Phe Gly Leu Pro Gly Lys Leu Val Val Ala Gly Thr Ile 
        115                 120                 125             


Ile Ile Gln Asn Ile Gly Ala Met Ser Ser Tyr Leu Leu Ile Ile Lys 
    130                 135                 140                 


Thr Glu Leu Pro Ala Ala Ile Ala Glu Phe Leu Thr Gly Asp Tyr Ser 
145                 150                 155                 160 


Arg Tyr Trp Tyr Leu Asp Gly Gln Thr Leu Leu Ile Ile Ile Cys Val 
                165                 170                 175     


Gly Ile Val Phe Pro Leu Ala Leu Leu Pro Lys Ile Gly Phe Leu Gly 
            180                 185                 190         


Tyr Thr Ser Ser Leu Ser Phe Phe Phe Met Met Phe Phe Ala Leu Val 
        195                 200                 205             


Val Ile Ile Lys Lys Trp Ser Ile Pro Cys Pro Leu Thr Leu Asn Tyr 
    210                 215                 220                 


Val Glu Lys Gly Phe Gln Ile Ser Asn Val Thr Asp Asp Cys Lys Pro 
225                 230                 235                 240 


Lys Leu Phe His Phe Ser Lys Glu Ser Ala Tyr Ala Leu Pro Thr Met 
                245                 250                 255     


Ala Phe Ser Phe Leu Cys His Thr Ser Ile Leu Pro Ile Tyr Cys Glu 
            260                 265                 270         


Leu Gln Ser Pro Ser Lys Lys Arg Met Gln Asn Val Thr Asn Thr Ala 
        275                 280                 285             


Ile Ala Leu Ser Phe Leu Ile Tyr Phe Ile Ser Ala Leu Phe Gly Tyr 
    290                 295                 300                 


Leu Thr Phe Tyr Asp Lys Val Glu Ser Glu Leu Leu Lys Gly Tyr Ser 
305                 310                 315                 320 


Lys Tyr Leu Ser His Asp Val Val Val Met Thr Val Lys Leu Cys Ile 
                325                 330                 335     


Leu Phe Ala Val Leu Leu Thr Val Pro Leu Ile His Phe Pro Ala Arg 
            340                 345                 350         


Lys Ala Val Thr Met Met Phe Phe Ser Asn Phe Pro Phe Ser Trp Ile 
        355                 360                 365             


Arg His Phe Leu Ile Thr Leu Ala Leu Asn Ile Ile Ile Val Leu Leu 
    370                 375                 380                 


Ala Ile Tyr Val Pro Asp Ile Arg Asn Val Phe Gly Val Val Gly Ala 
385                 390                 395                 400 


Ser Thr Ser Thr Cys Leu Ile Phe Ile Phe Pro Gly Leu Phe Tyr Leu 
                405                 410                 415     


Lys Leu Ser Arg Glu Asp Phe Leu Ser Trp Lys Lys Leu Gly Gly Leu 
            420                 425                 430         


Ile Leu Ser His Arg Leu Ala Cys Ser Gly Val Ile Ser Ala His Cys 
        435                 440                 445             


Asn Leu Cys Leu Pro Asp Ser Ser Asn Pro Pro Thr Ser Ala Ser Arg 
    450                 455                 460                 


Val Ala Glu Thr Thr Gly Arg Asp Thr Met Glu Met Cys Thr Gln Arg 
465                 470                 475                 480 


Lys Gly His Ala Arg Thr Gln Gln Glu Gly Asn Cys Leu Gln Ala Lys 
                485                 490                 495     


Gly Arg Gly Leu Arg Arg Thr Lys Arg Val His Thr Leu Ile Leu His 
            500                 505                 510         


Phe Pro Thr Ser Arg Thr Val Ser Lys 
        515                 520     


<210>  488
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  488

Met Glu Ala Ser Trp Gly Ser Phe Asn Ala Glu Arg Gly Trp Tyr Val 
1               5                   10                  15      


Ser Val Gln Gln Pro Glu Glu Ala Glu Ala Glu Glu Leu Ser Pro Leu 
            20                  25                  30          


Leu Ser Asn Glu Leu His Arg Gln Arg Ser Pro Gly Val Ser Phe Gly 
        35                  40                  45              


Leu Ser Val Phe Asn Leu Met Asn Ala Ile Met Gly Ser Gly Ile Leu 
    50                  55                  60                  


Gly Leu Ala Tyr Val Leu Ala Asn Thr Gly Val Phe Gly Phe Ser Phe 
65                  70                  75                  80  


Leu Leu Leu Thr Val Ala Leu Leu Ala Ser Tyr Ser Val His Leu Leu 
                85                  90                  95      


Leu Ser Met Cys Ile Gln Thr Ala Val Thr Ser Tyr Glu Asp Leu Gly 
            100                 105                 110         


Leu Phe Ala Phe Gly Leu Pro Gly Lys Leu Val Val Ala Gly Thr Ile 
        115                 120                 125             


Ile Ile Gln Asn Ile Gly Ala Met Ser Ser Tyr Leu Leu Ile Ile Lys 
    130                 135                 140                 


Thr Glu Leu Pro Ala Ala Ile Ala Glu Phe Leu Thr Gly Asp Tyr Ser 
145                 150                 155                 160 


Arg Tyr Trp Tyr Leu Asp Gly Gln Thr Leu Leu Ile Ile Ile Cys Val 
                165                 170                 175     


Gly Ile Val Phe Pro Leu Ala Leu Leu Pro Lys Ile Gly Phe Leu Gly 
            180                 185                 190         


Tyr Thr Ser Ser Leu Ser Phe Phe Phe Met Met Phe Phe Ala Leu Val 
        195                 200                 205             


Val Ile Ile Lys Lys Trp Ser Ile Pro Cys Pro Leu Thr Leu Asn Tyr 
    210                 215                 220                 


Val Glu Lys Gly Phe Gln Ile Ser Asn Val Thr Asp Asp Cys Lys Pro 
225                 230                 235                 240 


Lys Leu Phe His Phe Ser Lys Glu Ser Ala Tyr Ala Leu Pro Thr Met 
                245                 250                 255     


Ala Phe Ser Phe Leu Cys His Thr Ser Ile Leu Pro Ile Tyr Cys Glu 
            260                 265                 270         


Leu Gln Ser Pro Ser Lys Lys Arg Met Gln Asn Val Thr Asn Thr Ala 
        275                 280                 285             


Ile Ala Leu Ser Phe Leu Ile Tyr Phe Ile Ser Ala Leu Phe Gly Tyr 
    290                 295                 300                 


Leu Thr Phe Tyr Asp Lys Val Glu Ser Glu Leu Leu Lys Gly Tyr Ser 
305                 310                 315                 320 


Lys Tyr Leu Ser His Asp Val Val Val Met Thr Val Lys Leu Cys Ile 
                325                 330                 335     


Leu Phe Ala Val Leu Leu Thr Val Pro Leu Ile His Phe Pro Ala Arg 
            340                 345                 350         


Lys Ala Val Thr Met Met Phe Phe Ser Asn Phe Pro Phe Ser Trp Ile 
        355                 360                 365             


Arg His Phe Leu Ile Thr Leu Ala Leu Asn Ile Ile Ile Val Leu Leu 
    370                 375                 380                 


Ala Ile Tyr Val Pro Asp Ile Arg Asn Val Phe Gly Val Val Gly Ala 
385                 390                 395                 400 


Ser Thr Ser Thr Cys Leu Ile Phe Ile Phe Pro Gly Leu Phe Tyr Leu 
                405                 410                 415     


Lys Leu Ser Arg Glu Asp Phe Leu Ser Trp Lys Lys Leu Gly Ala Phe 
            420                 425                 430         


Val Leu Leu Ile Phe Gly Ile Leu Val Gly Asn Phe Ser Leu Ala Leu 
        435                 440                 445             


Ile Ile Phe Asp Trp Ile Asn Lys 
    450                 455     


<210>  489
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  489

Met Ala Glu Asp Lys Ser Lys Arg Asp Ser Ile Glu Met Ser Met Lys 
1               5                   10                  15      


Gly Cys Gln Thr Asn Asn Gly Phe Val His Asn Glu Asp Ile Leu Glu 
            20                  25                  30          


Gln Thr Pro Asp Pro Gly Ser Ser Thr Asp Asn Leu Lys His Ser Thr 
        35                  40                  45              


Arg Gly Ile Leu Gly Ser Gln Glu Pro Asp Phe Lys Gly Val Gln Pro 
    50                  55                  60                  


Tyr Ala Gly Met Pro Lys Glu Val Leu Phe Gln Phe Ser Gly Gln Ala 
65                  70                  75                  80  


Arg Tyr Arg Ile Pro Arg Glu Ile Leu Phe Trp Leu Thr Val Ala Ser 
                85                  90                  95      


Val Leu Val Leu Ile Ala Ala Thr Ile Ala Ile Ile Ala Leu Ser Pro 
            100                 105                 110         


Lys Cys Leu Asp Trp Trp Gln Glu Gly Pro Met Tyr Gln Ile Tyr Pro 
        115                 120                 125             


Arg Ser Phe Lys Asp Ser Asn Lys Asp Gly Asn Gly Asp Leu Lys Gly 
    130                 135                 140                 


Ile Gln Asp Lys Leu Asp Tyr Ile Thr Ala Leu Asn Ile Lys Thr Val 
145                 150                 155                 160 


Trp Ile Thr Ser Phe Tyr Lys Ser Ser Leu Lys Asp Phe Arg Tyr Gly 
                165                 170                 175     


Val Glu Asp Phe Arg Glu Val Asp Pro Ile Phe Gly Thr Met Glu Asp 
            180                 185                 190         


Phe Glu Asn Leu Val Ala Ala Ile His Asp Lys Gly Leu Lys Leu Ile 
        195                 200                 205             


Ile Asp Phe Ile Pro Asn His Thr Ser Asp Lys His Ile Trp Phe Gln 
    210                 215                 220                 


Leu Ser Arg Thr Arg Thr Gly Lys Tyr Thr Asp Tyr Tyr Ile Trp His 
225                 230                 235                 240 


Asp Cys Thr His Glu Asn Gly Lys Thr Ile Pro Pro Asn Asn Trp Leu 
                245                 250                 255     


Ser Val Tyr Gly Asn Ser Ser Trp His Phe Asp Glu Val Arg Asn Gln 
            260                 265                 270         


Cys Tyr Phe His Gln Phe Met Lys Glu Gln Pro Asp Leu Asn Phe Arg 
        275                 280                 285             


Asn Pro Asp Val Gln Glu Glu Ile Lys Glu Ile Leu Arg Phe Trp Leu 
    290                 295                 300                 


Thr Lys Gly Val Asp Gly Phe Ser Leu Asp Ala Val Lys Phe Leu Leu 
305                 310                 315                 320 


Glu Ala Lys His Leu Arg Asp Glu Ile Gln Val Asn Lys Thr Gln Ile 
                325                 330                 335     


Pro Asp Thr Val Thr Gln Tyr Ser Glu Leu Tyr His Asp Phe Thr Thr 
            340                 345                 350         


Thr Gln Val Gly Met His Asp Ile Val Arg Ser Phe Arg Gln Thr Met 
        355                 360                 365             


Asp Gln Tyr Ser Thr Glu Pro Gly Arg Tyr Arg Phe Met Gly Thr Glu 
    370                 375                 380                 


Ala Tyr Ala Glu Ser Ile Asp Arg Thr Val Met Tyr Tyr Gly Leu Pro 
385                 390                 395                 400 


Phe Ile Gln Glu Ala Asp Phe Pro Phe Asn Asn Tyr Leu Ser Met Leu 
                405                 410                 415     


Asp Thr Val Ser Gly Asn Ser Val Tyr Glu Val Ile Thr Ser Trp Met 
            420                 425                 430         


Glu Asn Met Pro Glu Gly Lys Trp Pro Asn Trp Met Ile Gly Gly Pro 
        435                 440                 445             


Asp Ser Ser Arg Leu Thr Ser Arg Leu Gly Asn Gln Tyr Val Asn Val 
    450                 455                 460                 


Met Asn Met Leu Leu Phe Thr Leu Pro Gly Thr Pro Ile Thr Tyr Tyr 
465                 470                 475                 480 


Gly Glu Glu Ile Gly Met Gly Asn Ile Val Ala Ala Asn Leu Asn Glu 
                485                 490                 495     


Ser Tyr Asp Ile Asn Thr Leu Arg Ser Lys Ser Pro Met Gln Trp Asp 
            500                 505                 510         


Asn Ser Ser Asn Ala Gly Phe Ser Glu Ala Ser Asn Thr Trp Leu Pro 
        515                 520                 525             


Thr Asn Ser Asp Tyr His Thr Val Asn Val Asp Val Gln Lys Thr Gln 
    530                 535                 540                 


Pro Arg Ser Ala Leu Lys Leu Tyr Gln Asp Leu Ser Leu Leu His Ala 
545                 550                 555                 560 


Asn Glu Leu Leu Leu Asn Arg Gly Trp Phe Cys His Leu Arg Asn Asp 
                565                 570                 575     


Ser His Tyr Val Val Tyr Thr Arg Glu Leu Asp Gly Ile Asp Arg Ile 
            580                 585                 590         


Phe Ile Val Val Leu Asn Phe Gly Glu Ser Thr Leu Leu Asn Leu His 
        595                 600                 605             


Asn Met Ile Ser Gly Leu Pro Ala Lys Met Arg Ile Arg Leu Ser Thr 
    610                 615                 620                 


Asn Ser Ala Asp Lys Gly Ser Lys Val Asp Thr Ser Gly Ile Phe Leu 
625                 630                 635                 640 


Asp Lys Gly Glu Gly Leu Ile Phe Glu His Asn Thr Lys Asn Leu Leu 
                645                 650                 655     


His Arg Gln Thr Ala Phe Arg Asp Arg Cys Phe Val Ser Asn Arg Ala 
            660                 665                 670         


Cys Tyr Ser Ser Val Leu Asn Ile Leu Tyr Thr Ser Cys 
        675                 680                 685 


<210>  490
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  490

Met Glu Gly Ser Ala Ser Pro Pro Glu Lys Pro Arg Ala Arg Pro Ala 
1               5                   10                  15      


Ala Ala Val Leu Cys Arg Gly Pro Val Glu Pro Leu Val Phe Leu Ala 
            20                  25                  30          


Asn Phe Ala Leu Val Leu Gln Gly Pro Leu Thr Thr Gln Tyr Leu Trp 
        35                  40                  45              


His Arg Phe Ser Ala Asp Leu Gly Tyr Asn Gly Thr Arg Gln Arg Gly 
    50                  55                  60                  


Gly Cys Ser Asn Arg Ser Ala Asp Pro Thr Met Gln Glu Val Glu Thr 
65                  70                  75                  80  


Leu Thr Ser His Trp Thr Leu Tyr Met Asn Val Gly Gly Phe Leu Val 
                85                  90                  95      


Gly Leu Phe Ser Ser Thr Leu Leu Gly Ala Trp Ser Asp Ser Val Gly 
            100                 105                 110         


Arg Arg Pro Leu Leu Val Leu Ala Ser Leu Gly Leu Leu Leu Gln Ala 
        115                 120                 125             


Leu Val Ser Val Phe Val Val Gln Leu Gln Leu His Val Gly Tyr Phe 
    130                 135                 140                 


Val Leu Gly Arg Ile Leu Cys Ala Leu Leu Gly Asp Phe Gly Gly Leu 
145                 150                 155                 160 


Leu Ala Ala Ser Phe Ala Ser Val Ala Asp Val Ser Ser Ser Arg Ser 
                165                 170                 175     


Arg Thr Phe Arg Met Ala Leu Leu Glu Ala Ser Ile Gly Val Ala Gly 
            180                 185                 190         


Met Leu Ala Ser Leu Leu Gly Gly His Trp Leu Arg Ala Gln Gly Tyr 
        195                 200                 205             


Ala Asn Pro Phe Trp Leu Ala Leu Ala Leu Leu Ile Ala Met Thr Leu 
    210                 215                 220                 


Tyr Ala Ala Phe Cys Phe Gly Glu Thr Leu Lys Glu Pro Lys Ser Thr 
225                 230                 235                 240 


Arg Leu Phe Thr Phe Arg His His Arg Ser Ile Val Gln Leu Tyr Val 
                245                 250                 255     


Ala Pro Ala Pro Glu Lys Ser Arg Lys His Leu Ala Leu Tyr Ser Leu 
            260                 265                 270         


Ala Ile Phe Val Val Ile Thr Val His Phe Gly Ala Gln Asp Ile Leu 
        275                 280                 285             


Thr Leu Tyr Glu Leu Ser Thr Pro Leu Cys Trp Asp Ser Lys Leu Ile 
    290                 295                 300                 


Gly Tyr Gly Ser Ala Ala Gln His Leu Pro Tyr Leu Thr Ser Leu Leu 
305                 310                 315                 320 


Ala Leu Lys Leu Leu Gln Tyr Cys Leu Ala Asp Ala Trp Val Ala Glu 
                325                 330                 335     


Ile Gly Leu Ala Phe Asn Ile Leu Gly Met Val Val Phe Ala Phe Ala 
            340                 345                 350         


Thr Ile Thr Pro Leu Met Phe Thr Gly Ala Leu Phe Ser Ala Val Ala 
        355                 360                 365             


Cys Val Asn Ser Leu Ala Met Leu Thr Ala Ser Gly Ile Phe Asn Ser 
    370                 375                 380                 


Leu Tyr Pro Ala Thr Leu Asn Phe Met Lys Gly Phe Pro Phe Leu Leu 
385                 390                 395                 400 


Gly Ala Gly Leu Leu Leu Ile Pro Ala Val Leu Ile Gly Met Leu Glu 
                405                 410                 415     


Lys Ala Asp Pro His Leu Glu Phe Gln Gln Phe Pro Gln Ser Pro 
            420                 425                 430     


<210>  491
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  491

Met Glu Gly Ser Ala Ser Pro Pro Glu Lys Pro Arg Ala Arg Pro Ala 
1               5                   10                  15      


Ala Ala Val Leu Cys Arg Gly Pro Val Glu Pro Leu Val Phe Leu Ala 
            20                  25                  30          


Asn Phe Ala Leu Val Leu Gln Gly Pro Leu Thr Thr Gln Tyr Leu Trp 
        35                  40                  45              


His Arg Phe Ser Ala Asp Leu Gly Tyr Asn Gly Thr Arg Gln Arg Gly 
    50                  55                  60                  


Gly Cys Ser Asn Arg Ser Ala Asp Pro Thr Met Gln Glu Val Glu Thr 
65                  70                  75                  80  


Leu Thr Ser His Trp Thr Leu Tyr Met Asn Val Gly Gly Phe Leu Val 
                85                  90                  95      


Gly Leu Phe Ser Ser Thr Leu Leu Gly Ala Trp Ser Asp Ser Val Gly 
            100                 105                 110         


Arg Arg Pro Leu Leu Val Leu Ala Ser Leu Gly Leu Leu Leu Gln Ala 
        115                 120                 125             


Leu Val Ser Val Phe Val Val Gln Leu Gln Leu His Val Gly Tyr Phe 
    130                 135                 140                 


Val Leu Gly Arg Ile Leu Cys Ala Leu Leu Gly Asp Phe Gly Gly Leu 
145                 150                 155                 160 


Leu Ala Ala Ser Phe Ala Ser Val Ala Asp Val Ser Ser Ser Arg Ser 
                165                 170                 175     


Arg Thr Phe Arg Met Ala Leu Leu Glu Ala Ser Ile Gly Val Ala Gly 
            180                 185                 190         


Met Leu Ala Ser Leu Leu Gly Gly His Trp Leu Arg Ala Gln Gly Tyr 
        195                 200                 205             


Ala Asn Pro Phe Trp Leu Ala Leu Ala Leu Leu Ile Ala Met Thr Leu 
    210                 215                 220                 


Tyr Ala Ala Phe Cys Phe Gly Glu Thr Leu Lys Glu Pro Lys Ser Thr 
225                 230                 235                 240 


Arg Leu Phe Thr Phe Arg His His Arg Ser Ile Val Gln Leu Tyr Val 
                245                 250                 255     


Ala Pro Ala Pro Glu Lys Ser Arg Lys His Leu Ala Leu Tyr Ser Leu 
            260                 265                 270         


Ala Ile Phe Val Val Ile Thr Val His Phe Gly Ala Gln Asp Ile Leu 
        275                 280                 285             


Thr Leu Tyr Glu Leu Ser Thr Pro Leu Cys Trp Asp Ser Lys Leu Ile 
    290                 295                 300                 


Gly Tyr Gly Ser Ala Ala Gln His Leu Pro Tyr Leu Thr Ser Leu Leu 
305                 310                 315                 320 


Ala Leu Lys Leu Leu Gln Tyr Cys Leu Ala Asp Ala Trp Val Ala Glu 
                325                 330                 335     


Ile Gly Leu Ala Phe Asn Ile Leu Gly Met Val Val Phe Ala Phe Ala 
            340                 345                 350         


Thr Ile Thr Pro Leu Met Phe Thr Gly Tyr Gly Leu Leu Phe Leu Ser 
        355                 360                 365             


Leu Val Ile Thr Pro Val Ile Arg Ala Lys Leu Ser Lys Leu Val Arg 
    370                 375                 380                 


Glu Thr Glu Gln Gly Ala Leu Phe Ser Ala Val Ala Cys Val Asn Ser 
385                 390                 395                 400 


Leu Ala Met Leu Thr Ala Ser Gly Ile Phe Asn Ser Leu Tyr Pro Ala 
                405                 410                 415     


Thr Leu Asn Phe Met Lys Gly Phe Pro Phe Leu Leu Gly Ala Gly Leu 
            420                 425                 430         


Leu Leu Ile Pro Ala Val Leu Ile Gly Met Leu Glu Lys Ala Asp Pro 
        435                 440                 445             


His Leu Glu Phe Gln Gln Phe Pro Gln Ser Pro 
    450                 455                 


<210>  492
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  492

Met Ser Val Gly Val Ser Thr Ser Ala Pro Leu Ser Pro Thr Ser Gly 
1               5                   10                  15      


Thr Ser Val Gly Met Ser Thr Phe Ser Ile Met Asp Tyr Val Val Phe 
            20                  25                  30          


Val Leu Leu Leu Val Leu Ser Leu Ala Ile Gly Leu Tyr His Ala Cys 
        35                  40                  45              


Arg Gly Trp Gly Arg His Thr Val Gly Glu Leu Leu Met Ala Asp Arg 
    50                  55                  60                  


Lys Met Gly Cys Leu Pro Val Ala Leu Ser Leu Leu Ala Thr Phe Gln 
65                  70                  75                  80  


Ser Ala Val Ala Ile Leu Gly Val Pro Ser Glu Ile Tyr Arg Phe Gly 
                85                  90                  95      


Thr Gln Tyr Trp Phe Leu Gly Cys Cys Tyr Phe Leu Gly Leu Leu Ile 
            100                 105                 110         


Pro Ala His Ile Phe Ile Pro Val Phe Tyr Arg Leu His Leu Thr Ser 
        115                 120                 125             


Ala Tyr Glu Tyr Leu Glu Leu Arg Phe Asn Lys Thr Val Arg Val Cys 
    130                 135                 140                 


Gly Thr Val Thr Phe Ile Phe Gln Met Val Ile Tyr Met Gly Val Val 
145                 150                 155                 160 


Leu Tyr Ala Pro Ser Leu Ala Leu Asn Ala Val Thr Gly Phe Asp Leu 
                165                 170                 175     


Trp Leu Ser Val Leu Ala Leu Gly Ile Val Cys Thr Val Tyr Thr Ala 
            180                 185                 190         


Leu Gly Gly Leu Lys Ala Val Ile Trp Thr Asp Val Phe Gln Thr Leu 
        195                 200                 205             


Val Met Phe Leu Gly Gln Leu Ala Val Ile Ile Val Gly Ser Ala Lys 
    210                 215                 220                 


Val Gly Gly Leu Gly Arg Val Trp Ala Val Ala Ser Gln His Gly Arg 
225                 230                 235                 240 


Ile Ser Gly Phe Glu Leu Asp Pro Asp Pro Phe Val Arg His Thr Phe 
                245                 250                 255     


Trp Thr Leu Ala Phe Gly Gly Val Phe Met Met Leu Ser Leu Tyr Gly 
            260                 265                 270         


Val Asn Gln Ala Gln Val Gln Arg Tyr Leu Ser Ser Arg Thr Glu Lys 
        275                 280                 285             


Ala Ala Val Leu Ser Cys Tyr Ala Val Phe Pro Phe Gln Gln Val Ser 
    290                 295                 300                 


Leu Cys Val Gly Cys Leu Ile Gly Leu Val Met Phe Ala Tyr Tyr Gln 
305                 310                 315                 320 


Glu Tyr Pro Met Ser Ile Gln Gln Ala Gln Ala Ala Pro Asp Gln Phe 
                325                 330                 335     


Val Leu Tyr Phe Val Met Asp Leu Leu Lys Gly Leu Pro Gly Leu Pro 
            340                 345                 350         


Gly Leu Phe Ile Ala Cys Leu Phe Ser Gly Ser Leu Ser Thr Ile Ser 
        355                 360                 365             


Ser Ala Phe Asn Ser Leu Ala Thr Val Thr Met Glu Asp Leu Ile Arg 
    370                 375                 380                 


Pro Trp Phe Pro Glu Phe Ser Glu Ala Arg Ala Ile Met Leu Ser Arg 
385                 390                 395                 400 


Gly Leu Ala Phe Gly Tyr Gly Leu Leu Cys Leu Gly Met Ala Tyr Ile 
                405                 410                 415     


Ser Ser Gln Met Gly Pro Val Leu Gln Ala Ala Ile Ser Ile Phe Gly 
            420                 425                 430         


Met Val Gly Gly Pro Leu Leu Gly Leu Phe Cys Leu Gly Met Phe Phe 
        435                 440                 445             


Pro Cys Ala Asn Pro Pro Gly Ala Val Val Gly Leu Leu Ala Gly Leu 
    450                 455                 460                 


Val Met Ala Phe Trp Ile Gly Ile Gly Ser Ile Val Thr Ser Met Gly 
465                 470                 475                 480 


Ser Ser Met Pro Pro Ser Pro Ser Asn Gly Ser Ser Phe Ser Leu Pro 
                485                 490                 495     


Thr Asn Leu Thr Val Ala Thr Val Thr Thr Leu Met Pro Leu Thr Thr 
            500                 505                 510         


Phe Ser Lys Pro Thr Gly Leu Gln Arg Phe Tyr Ser Leu Ser Tyr Leu 
        515                 520                 525             


Trp Tyr Ser Ala His Asn Ser Thr Thr Val Ile Val Val Gly Leu Ile 
    530                 535                 540                 


Val Ser Leu Leu Thr Gly Arg Met Arg Gly Arg Ser Leu Asn Pro Ala 
545                 550                 555                 560 


Thr Ile Tyr Pro Val Leu Pro Lys Leu Leu Ser Leu Leu Pro Leu Ser 
                565                 570                 575     


Cys Gln Lys Arg Leu His Cys Arg Ser Tyr Gly Gln Asp His Leu Asp 
            580                 585                 590         


Thr Gly Leu Phe Pro Glu Lys Pro Arg Asn Gly Val Leu Gly Asp Ser 
        595                 600                 605             


Arg Asp Lys Glu Ala Met Ala Leu Asp Gly Thr Ala Tyr Gln Gly Ser 
    610                 615                 620                 


Ser Ser Thr Cys Ile Leu Gln Glu Thr Ser Leu 
625                 630                 635 


<210>  493
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  493

Met Ala Thr Asn Gly Ser Lys Val Ala Asp Gly Gln Ile Ser Thr Glu 
1               5                   10                  15      


Val Ser Glu Ala Pro Val Ala Asn Asp Lys Pro Lys Thr Leu Val Val 
            20                  25                  30          


Lys Val Gln Lys Lys Ala Ala Asp Leu Pro Asp Arg Asp Thr Trp Lys 
        35                  40                  45              


Gly Arg Phe Asp Phe Leu Met Ser Cys Val Gly Tyr Ala Ile Gly Leu 
    50                  55                  60                  


Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gly Lys Asn Gly Gly Gly 
65                  70                  75                  80  


Ala Phe Leu Ile Pro Tyr Phe Leu Thr Leu Ile Phe Ala Gly Val Pro 
                85                  90                  95      


Leu Phe Leu Leu Glu Cys Ser Leu Gly Gln Tyr Thr Ser Ile Gly Gly 
            100                 105                 110         


Leu Gly Val Trp Lys Leu Ala Pro Met Phe Lys Gly Val Gly Leu Ala 
        115                 120                 125             


Ala Ala Val Leu Ser Phe Trp Leu Asn Ile Tyr Tyr Ile Val Ile Ile 
    130                 135                 140                 


Ser Trp Ala Ile Tyr Tyr Leu Tyr Asn Ser Phe Thr Thr Thr Leu Pro 
145                 150                 155                 160 


Trp Lys Gln Cys Asp Asn Pro Trp Asn Thr Asp Arg Cys Phe Ser Asn 
                165                 170                 175     


Tyr Ser Met Val Asn Thr Thr Asn Met Thr Ser Ala Val Val Glu Phe 
            180                 185                 190         


Trp Glu Arg Asn Met His Gln Met Thr Asp Gly Leu Asp Lys Pro Gly 
        195                 200                 205             


Gln Ile Arg Trp Pro Leu Ala Ile Thr Leu Ala Ile Ala Trp Ile Leu 
    210                 215                 220                 


Val Tyr Phe Cys Ile Trp Lys Gly Val Gly Trp Thr Gly Lys Val Val 
225                 230                 235                 240 


Tyr Phe Ser Ala Thr Tyr Pro Tyr Ile Met Leu Ile Ile Leu Phe Phe 
                245                 250                 255     


Arg Gly Val Thr Leu Pro Gly Ala Lys Glu Gly Ile Leu Phe Tyr Ile 
            260                 265                 270         


Thr Pro Asn Phe Arg Lys Leu Ser Asp Ser Glu Val Trp Leu Asp Ala 
        275                 280                 285             


Ala Thr Gln Ile Phe Phe Ser Tyr Gly Leu Gly Leu Gly Ser Leu Ile 
    290                 295                 300                 


Ala Leu Gly Ser Tyr Asn Ser Phe His Asn Asn Val Tyr Arg Asp Ser 
305                 310                 315                 320 


Ile Ile Val Cys Cys Ile Asn Ser Cys Thr Ser Met Phe Ala Gly Phe 
                325                 330                 335     


Val Ile Phe Ser Ile Val Gly Phe Met Ala His Val Thr Lys Arg Ser 
            340                 345                 350         


Ile Ala Asp Val Ala Ala Ser Gly Pro Gly Leu Ala Phe Leu Ala Tyr 
        355                 360                 365             


Pro Glu Ala Val Thr Gln Leu Pro Ile Ser Pro Leu Trp Ala Ile Leu 
    370                 375                 380                 


Phe Phe Ser Met Leu Leu Met Leu Gly Ile Asp Ser Gln Phe Cys Thr 
385                 390                 395                 400 


Val Glu Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr Pro Arg Leu Leu 
                405                 410                 415     


Arg Asn Arg Arg Glu Leu Phe Ile Ala Ala Val Cys Ile Ile Ser Tyr 
            420                 425                 430         


Leu Ile Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile Tyr Val Phe Lys 
        435                 440                 445             


Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu Leu Phe Leu Val 
    450                 455                 460                 


Phe Phe Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly Val Asn Arg Phe 
465                 470                 475                 480 


Tyr Asp Asn Ile Gln Glu Met Val Gly Ser Arg Pro Cys Ile Trp Trp 
                485                 490                 495     


Lys Leu Cys Trp Ser Phe Phe Thr Pro Ile Ile Val Ala Gly Val Phe 
            500                 505                 510         


Ile Phe Ser Ala Val Gln Met Thr Pro Leu Thr Met Gly Asn Tyr Val 
        515                 520                 525             


Phe Pro Lys Trp Gly Gln Gly Val Gly Trp Leu Met Ala Leu Ser Ser 
    530                 535                 540                 


Met Val Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe Leu Thr Leu Lys 
545                 550                 555                 560 


Gly Ser Leu Lys Gln Arg Ile Gln Val Met Val Gln Pro Ser Glu Asp 
                565                 570                 575     


Ile Val Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln Ala Gly Ser Ser 
            580                 585                 590         


Thr Ser Lys Glu Ala Tyr Ile 
        595                 


<210>  494
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  494

Met Ala Thr Asn Gly Ser Lys Val Ala Asp Gly Gln Ile Ser Thr Glu 
1               5                   10                  15      


Val Ser Glu Ala Pro Val Ala Asn Asp Lys Pro Lys Thr Leu Val Val 
            20                  25                  30          


Lys Val Gln Lys Lys Ala Ala Asp Leu Pro Asp Arg Asp Thr Trp Lys 
        35                  40                  45              


Gly Arg Phe Asp Phe Leu Met Ser Cys Val Gly Tyr Ala Ile Gly Leu 
    50                  55                  60                  


Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gly Lys Asn Gly Gly Gly 
65                  70                  75                  80  


Ala Phe Leu Ile Pro Tyr Phe Leu Thr Leu Ile Phe Ala Gly Val Pro 
                85                  90                  95      


Leu Phe Leu Leu Glu Cys Ser Leu Gly Gln Tyr Thr Ser Ile Gly Gly 
            100                 105                 110         


Leu Gly Val Trp Lys Leu Ala Pro Met Phe Lys Gly Val Gly Leu Ala 
        115                 120                 125             


Ala Ala Val Leu Ser Phe Trp Leu Asn Ile Tyr Tyr Ile Val Ile Ile 
    130                 135                 140                 


Ser Trp Ala Ile Tyr Tyr Leu Tyr Asn Ser Phe Thr Thr Thr Leu Pro 
145                 150                 155                 160 


Trp Lys Gln Cys Asp Asn Pro Trp Asn Thr Asp Arg Cys Phe Ser Asn 
                165                 170                 175     


Tyr Ser Met Val Asn Thr Thr Asn Met Thr Ser Ala Val Val Glu Phe 
            180                 185                 190         


Trp Glu Arg Asn Met His Gln Met Thr Asp Gly Leu Asp Lys Pro Gly 
        195                 200                 205             


Gln Ile Arg Trp Pro Leu Ala Ile Thr Leu Ala Ile Ala Trp Ile Leu 
    210                 215                 220                 


Val Tyr Phe Cys Ile Trp Lys Gly Val Gly Trp Thr Gly Lys Val Val 
225                 230                 235                 240 


Tyr Phe Ser Ala Thr Tyr Pro Tyr Ile Met Leu Ile Ile Leu Phe Phe 
                245                 250                 255     


Arg Gly Val Thr Leu Pro Gly Ala Lys Glu Gly Ile Leu Phe Tyr Ile 
            260                 265                 270         


Thr Pro Asn Phe Arg Lys Leu Ser Asp Ser Glu Val Trp Leu Asp Ala 
        275                 280                 285             


Ala Thr Gln Ile Phe Phe Ser Tyr Gly Leu Gly Leu Gly Ser Leu Ile 
    290                 295                 300                 


Ala Leu Gly Ser Tyr Asn Ser Phe His Asn Asn Val Tyr Arg Asp Ser 
305                 310                 315                 320 


Ile Ile Val Cys Cys Ile Asn Ser Cys Thr Ser Met Phe Ala Gly Phe 
                325                 330                 335     


Val Ile Phe Ser Ile Val Gly Phe Met Ala His Val Thr Lys Arg Ser 
            340                 345                 350         


Ile Ala Asp Val Ala Ala Ser Gly Pro Gly Leu Ala Phe Leu Ala Tyr 
        355                 360                 365             


Pro Glu Ala Val Thr Gln Leu Pro Ile Ser Pro Leu Trp Ala Ile Leu 
    370                 375                 380                 


Phe Phe Ser Met Leu Leu Met Leu Gly Ile Asp Ser Gln Phe Cys Thr 
385                 390                 395                 400 


Val Glu Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr Pro Arg Leu Leu 
                405                 410                 415     


Arg Asn Arg Arg Glu Leu Phe Ile Ala Ala Val Cys Ile Ile Ser Tyr 
            420                 425                 430         


Leu Ile Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile Tyr Val Phe Lys 
        435                 440                 445             


Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu Leu Phe Leu Val 
    450                 455                 460                 


Phe Phe Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly Val Asn Arg Phe 
465                 470                 475                 480 


Tyr Asp Asn Ile Gln Glu Met Val Gly Ser Arg Pro Cys Ile Trp Trp 
                485                 490                 495     


Lys Leu Cys Trp Ser Phe Phe Thr Pro Ile Ile Val Ala Gly Val Phe 
            500                 505                 510         


Ile Phe Ser Ala Val Gln Met Thr Pro Leu Thr Met Gly Asn Tyr Val 
        515                 520                 525             


Phe Pro Lys Trp Gly Gln Gly Val Gly Trp Leu Met Ala Leu Ser Ser 
    530                 535                 540                 


Met Val Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe Leu Thr Leu Lys 
545                 550                 555                 560 


Gly Ser Leu Lys Gln Arg Ile Gln Val Met Val Gln Pro Ser Glu Asp 
                565                 570                 575     


Ile Val Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln Ala Gly Ser Ser 
            580                 585                 590         


Thr Ser Lys Glu Ala Tyr Ile 
        595                 


<210>  495
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  495

Met Asp Lys Leu Lys Cys Pro Ser Phe Phe Lys Cys Arg Glu Lys Glu 
1               5                   10                  15      


Lys Val Ser Ala Ser Ser Glu Asn Phe His Val Gly Glu Asn Asp Glu 
            20                  25                  30          


Asn Gln Asp Arg Gly Asn Trp Ser Lys Lys Ser Asp Tyr Leu Leu Ser 
        35                  40                  45              


Met Ile Gly Tyr Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
    50                  55                  60                  


Leu Thr Tyr Ser Asn Gly Gly Gly Ala Phe Leu Ile Pro Tyr Ala Ile 
65                  70                  75                  80  


Met Leu Ala Leu Ala Gly Leu Pro Leu Phe Phe Leu Glu Cys Ser Leu 
                85                  90                  95      


Gly Gln Phe Ala Ser Leu Gly Pro Val Ser Val Trp Arg Ile Leu Pro 
            100                 105                 110         


Leu Phe Gln Gly Val Gly Ile Thr Met Val Leu Ile Ser Ile Phe Val 
        115                 120                 125             


Thr Ile Tyr Tyr Asn Val Ile Ile Ala Tyr Ser Leu Tyr Tyr Met Phe 
    130                 135                 140                 


Ala Ser Phe Gln Ser Glu Leu Pro Trp Lys Asn Cys Ser Ser Trp Ser 
145                 150                 155                 160 


Asp Lys Asn Cys Ser Arg Ser Pro Ile Val Thr His Cys Asn Val Ser 
                165                 170                 175     


Thr Val Asn Lys Gly Ile Gln Glu Ile Ile Gln Met Asn Lys Ser Trp 
            180                 185                 190         


Val Asp Ile Asn Asn Phe Thr Cys Ile Asn Gly Ser Glu Ile Tyr Gln 
        195                 200                 205             


Pro Gly Gln Leu Pro Ser Glu Gln Tyr Trp Asn Lys Val Ala Leu Gln 
    210                 215                 220                 


Arg Ser Ser Gly Met Asn Glu Thr Gly Val Ile Val Trp Tyr Leu Ala 
225                 230                 235                 240 


Leu Cys Leu Leu Leu Ala Trp Leu Ile Val Gly Ala Ala Leu Phe Lys 
                245                 250                 255     


Gly Ile Lys Ser Ser Gly Lys Val Val Tyr Phe Thr Ala Leu Phe Pro 
            260                 265                 270         


Tyr Val Val Leu Leu Ile Leu Leu Val Arg Gly Ala Thr Leu Glu Gly 
        275                 280                 285             


Ala Ser Lys Gly Ile Ser Tyr Tyr Ile Gly Ala Gln Ser Asn Phe Thr 
    290                 295                 300                 


Lys Leu Lys Glu Ala Glu Val Trp Lys Asp Ala Ala Thr Gln Ile Phe 
305                 310                 315                 320 


Tyr Ser Leu Ser Val Ala Trp Gly Gly Leu Val Ala Leu Ser Ser Tyr 
                325                 330                 335     


Asn Lys Phe Lys Asn Asn Cys Phe Ser Asp Ala Ile Val Val Cys Leu 
            340                 345                 350         


Thr Asn Cys Leu Thr Ser Val Phe Ala Gly Phe Ala Ile Phe Ser Ile 
        355                 360                 365             


Leu Gly His Met Ala His Ile Ser Gly Lys Glu Val Ser Gln Val Val 
    370                 375                 380                 


Lys Ser Gly Phe Asp Leu Ala Phe Ile Ala Tyr Pro Glu Ala Leu Ala 
385                 390                 395                 400 


Gln Leu Pro Gly Gly Pro Phe Trp Ser Ile Leu Phe Phe Phe Met Leu 
                405                 410                 415     


Leu Thr Leu Gly Leu Asp Ser Gln Phe Ala Ser Ile Glu Thr Ile Thr 
            420                 425                 430         


Thr Thr Ile Gln Asp Leu Phe Pro Lys Val Met Lys Lys Met Arg Val 
        435                 440                 445             


Pro Ile Thr Leu Gly Cys Cys Leu Val Leu Phe Leu Leu Gly Leu Val 
    450                 455                 460                 


Cys Val Thr Gln Ala Gly Ile Tyr Trp Val His Leu Ile Asp His Phe 
465                 470                 475                 480 


Cys Ala Gly Trp Gly Ile Leu Ile Ala Ala Ile Leu Glu Leu Val Gly 
                485                 490                 495     


Ile Ile Trp Ile Tyr Gly Gly Asn Arg Phe Ile Glu Asp Thr Glu Met 
            500                 505                 510         


Met Ile Gly Ala Lys Arg Trp Ile Phe Trp Leu Trp Trp Arg Ala Cys 
        515                 520                 525             


Trp Phe Val Ile Thr Pro Ile Leu Leu Ile Ala Ile Phe Ile Trp Ser 
    530                 535                 540                 


Leu Val Gln Phe His Arg Pro Asn Tyr Gly Ala Ile Pro Tyr Pro Asp 
545                 550                 555                 560 


Trp Gly Val Ala Leu Gly Trp Cys Met Ile Val Phe Cys Ile Ile Trp 
                565                 570                 575     


Ile Pro Ile Met Ala Ile Ile Lys Ile Ile Gln Ala Lys Gly Asn Ile 
            580                 585                 590         


Phe Gln Arg Leu Ile Ser Cys Cys Arg Pro Ala Ser Asn Trp Gly Pro 
        595                 600                 605             


Tyr Leu Glu Gln His Arg Gly Glu Arg Tyr Lys Asp Met Val Asp Pro 
    610                 615                 620                 


Lys Lys Glu Ala Asp His Glu Ile Pro Thr Val Ser Gly Ser Arg Lys 
625                 630                 635                 640 


Pro Glu 
        


<210>  496
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  496

Met Glu Thr Thr Pro Leu Asn Ser Gln Lys Gln Leu Ser Ala Cys Glu 
1               5                   10                  15      


Asp Gly Glu Asp Cys Gln Glu Asn Gly Val Leu Gln Lys Val Val Pro 
            20                  25                  30          


Thr Pro Gly Asp Lys Val Glu Ser Gly Gln Ile Ser Asn Gly Tyr Ser 
        35                  40                  45              


Ala Val Pro Ser Pro Gly Ala Gly Asp Asp Thr Arg His Ser Ile Pro 
    50                  55                  60                  


Ala Thr Thr Thr Thr Leu Val Ala Glu Leu His Gln Gly Glu Arg Glu 
65                  70                  75                  80  


Thr Trp Gly Lys Lys Val Asp Phe Leu Leu Ser Val Ile Gly Tyr Ala 
                85                  90                  95      


Val Asp Leu Gly Asn Val Trp Arg Phe Pro Tyr Ile Cys Tyr Gln Asn 
            100                 105                 110         


Gly Gly Gly Ala Phe Leu Leu Pro Tyr Thr Ile Met Ala Ile Phe Gly 
        115                 120                 125             


Gly Ile Pro Leu Phe Tyr Met Glu Leu Ala Leu Gly Gln Tyr His Arg 
    130                 135                 140                 


Asn Gly Cys Ile Ser Ile Trp Arg Lys Ile Cys Pro Ile Phe Lys Gly 
145                 150                 155                 160 


Ile Gly Tyr Ala Ile Cys Ile Ile Ala Phe Tyr Ile Ala Ser Tyr Tyr 
                165                 170                 175     


Asn Thr Ile Met Ala Trp Ala Leu Tyr Tyr Leu Ile Ser Ser Phe Thr 
            180                 185                 190         


Asp Gln Leu Pro Trp Thr Ser Cys Lys Asn Ser Trp Asn Thr Gly Asn 
        195                 200                 205             


Cys Thr Asn Tyr Phe Ser Glu Asp Asn Ile Thr Trp Thr Leu His Ser 
    210                 215                 220                 


Thr Ser Pro Ala Glu Glu Phe Tyr Thr Arg His Val Leu Gln Ile His 
225                 230                 235                 240 


Arg Ser Lys Gly Leu Gln Asp Leu Gly Gly Ile Ser Trp Gln Leu Ala 
                245                 250                 255     


Leu Cys Ile Met Leu Ile Phe Thr Val Ile Tyr Phe Ser Ile Trp Lys 
            260                 265                 270         


Gly Val Lys Thr Ser Gly Lys Val Val Trp Val Thr Ala Thr Phe Pro 
        275                 280                 285             


Tyr Ile Ile Leu Ser Val Leu Leu Val Arg Gly Ala Thr Leu Pro Gly 
    290                 295                 300                 


Ala Trp Arg Gly Val Leu Phe Tyr Leu Lys Pro Asn Trp Gln Lys Leu 
305                 310                 315                 320 


Leu Glu Thr Gly Val Trp Ile Asp Ala Ala Ala Gln Ile Phe Phe Ser 
                325                 330                 335     


Leu Gly Pro Gly Phe Gly Val Leu Leu Ala Phe Ala Ser Tyr Asn Lys 
            340                 345                 350         


Phe Asn Asn Asn Cys Tyr Gln Asp Ala Leu Val Thr Ser Val Val Asn 
        355                 360                 365             


Cys Met Thr Ser Phe Val Ser Gly Phe Val Ile Phe Thr Val Leu Gly 
    370                 375                 380                 


Tyr Met Ala Glu Met Arg Asn Glu Asp Val Ser Glu Val Ala Lys Asp 
385                 390                 395                 400 


Ala Gly Pro Ser Leu Leu Phe Ile Thr Tyr Ala Glu Ala Ile Ala Asn 
                405                 410                 415     


Met Pro Ala Ser Thr Phe Phe Ala Ile Ile Phe Phe Leu Met Leu Ile 
            420                 425                 430         


Thr Leu Gly Leu Asp Ser Thr Phe Ala Gly Leu Glu Gly Val Ile Thr 
        435                 440                 445             


Ala Val Leu Asp Glu Phe Pro His Val Trp Ala Lys Arg Arg Glu Arg 
    450                 455                 460                 


Phe Val Leu Ala Val Val Ile Thr Cys Phe Phe Gly Ser Leu Val Thr 
465                 470                 475                 480 


Leu Thr Phe Gly Gly Ala Tyr Val Val Lys Leu Leu Glu Glu Tyr Ala 
                485                 490                 495     


Thr Gly Pro Ala Val Leu Thr Val Ala Leu Ile Glu Ala Val Ala Val 
            500                 505                 510         


Ser Trp Phe Tyr Gly Ile Thr Gln Phe Cys Arg Asp Val Lys Glu Met 
        515                 520                 525             


Leu Gly Phe Ser Pro Gly Trp Phe Trp Arg Ile Cys Trp Val Ala Ile 
    530                 535                 540                 


Ser Pro Leu Phe Leu Leu Phe Ile Ile Cys Ser Phe Leu Met Ser Pro 
545                 550                 555                 560 


Pro Gln Leu Arg Leu Phe Gln Tyr Asn Tyr Pro Tyr Trp Ser Ile Ile 
                565                 570                 575     


Leu Gly Tyr Cys Ile Gly Thr Ser Ser Phe Ile Cys Ile Pro Thr Tyr 
            580                 585                 590         


Ile Ala Tyr Arg Leu Ile Ile Thr Pro Gly Thr Phe Lys Glu Arg Ile 
        595                 600                 605             


Ile Lys Ser Ile Thr Pro Glu Thr Pro Thr Glu Ile Pro Cys Gly Asp 
    610                 615                 620                 


Ile Arg Leu Asn Ala Val 
625                 630 


<210>  497
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  497

Met Glu Arg Gly Ile Ser Asp Val Thr Asp Arg Lys Leu Thr Met Glu 
1               5                   10                  15      


Glu Glu Glu Ala Lys Arg Ile Ala Glu Met Gly Lys Pro Val Leu Gly 
            20                  25                  30          


Glu His Pro Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr Glu Phe Lys 
        35                  40                  45              


Thr Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala Leu Val Val 
    50                  55                  60                  


Gly Thr His Ser Trp Arg Asp Gln Phe Met Glu Ala Ile Thr Val Ser 
65                  70                  75                  80  


Ala Ala Gly Asp Glu Asp Glu Asp Glu Ser Gly Glu Glu Arg Leu Pro 
                85                  90                  95      


Ser Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp Lys Val 
            100                 105                 110         


Leu Phe Ala Cys Val Pro Pro Thr Glu Tyr Cys His Gly Trp Ala Cys 
        115                 120                 125             


Phe Ala Val Ser Ile Leu Ile Ile Gly Met Leu Thr Ala Ile Ile Gly 
    130                 135                 140                 


Asp Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys Asp Ser Val 
145                 150                 155                 160 


Thr Ala Val Val Phe Val Ala Phe Gly Thr Ser Val Pro Asp Thr Phe 
                165                 170                 175     


Ala Ser Lys Ala Ala Ala Leu Gln Asp Val Tyr Ala Asp Ala Ser Ile 
            180                 185                 190         


Gly Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly Ile Gly 
        195                 200                 205             


Leu Ala Trp Ser Val Ala Ala Ile Tyr Trp Ala Leu Gln Gly Gln Glu 
    210                 215                 220                 


Phe His Val Ser Ala Gly Thr Leu Ala Phe Ser Val Thr Leu Phe Thr 
225                 230                 235                 240 


Ile Phe Ala Phe Val Cys Ile Ser Val Leu Leu Tyr Arg Arg Arg Pro 
                245                 250                 255     


His Leu Gly Gly Glu Leu Gly Gly Pro Arg Gly Cys Lys Leu Ala Thr 
            260                 265                 270         


Thr Trp Leu Phe Val Ser Leu Trp Leu Leu Tyr Ile Leu Phe Ala Thr 
        275                 280                 285             


Leu Glu Ala Tyr Cys Tyr Ile Lys Gly Phe 
    290                 295             


<210>  498
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  498

Met Ala Trp Leu Arg Leu Gln Pro Leu Thr Ser Ala Phe Leu His Phe 
1               5                   10                  15      


Gly Leu Val Thr Phe Val Leu Phe Leu Asn Gly Leu Arg Ala Glu Ala 
            20                  25                  30          


Gly Gly Ser Gly Asp Val Pro Ser Thr Gly Gln Asn Asn Glu Ser Cys 
        35                  40                  45              


Ser Gly Ser Ser Asp Cys Lys Glu Gly Val Ile Leu Pro Ile Trp Tyr 
    50                  55                  60                  


Pro Glu Asn Pro Ser Leu Gly Asp Lys Ile Ala Arg Val Ile Val Tyr 
65                  70                  75                  80  


Phe Val Ala Leu Ile Tyr Met Phe Leu Gly Val Ser Ile Ile Ala Asp 
                85                  90                  95      


Arg Phe Met Ala Ser Ile Glu Val Ile Thr Ser Gln Glu Arg Glu Val 
            100                 105                 110         


Thr Ile Lys Lys Pro Asn Gly Glu Thr Ser Thr Thr Thr Ile Arg Val 
        115                 120                 125             


Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser Ser 
    130                 135                 140                 


Ala Pro Glu Ile Leu Leu Ser Leu Ile Glu Val Cys Gly His Gly Phe 
145                 150                 155                 160 


Ile Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala Phe 
                165                 170                 175     


Asn Met Phe Ile Ile Ile Gly Ile Cys Val Tyr Val Ile Pro Asp Gly 
            180                 185                 190         


Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Ile Thr Ala Ala 
        195                 200                 205             


Trp Ser Ile Phe Ala Tyr Ile Trp Leu Tyr Met Ile Leu Ala Val Phe 
    210                 215                 220                 


Ser Pro Gly Val Val Gln Val Trp Glu Gly Leu Leu Thr Leu Phe Phe 
225                 230                 235                 240 


Phe Pro Val Cys Val Leu Leu Ala Trp Val Ala Asp Lys Arg Leu Leu 
                245                 250                 255     


Phe Tyr Lys Tyr Met His Lys Lys Tyr Arg Thr Asp Lys His Arg Gly 
            260                 265                 270         


Ile Ile Ile Glu Thr Glu Gly Asp His Pro Lys Gly Ile Glu Met Asp 
        275                 280                 285             


Gly Lys Met Met Asn Ser His Phe Leu Asp Gly Asn Leu Val Pro Leu 
    290                 295                 300                 


Glu Gly Lys Glu Val Asp Glu Ser Arg Arg Glu Met Ile Arg Ile Leu 
305                 310                 315                 320 


Lys Asp Leu Lys Gln Lys His Pro Glu Lys Asp Leu Asp Gln Leu Val 
                325                 330                 335     


Glu Met Ala Asn Tyr Tyr Ala Leu Ser His Gln Gln Lys Ser Arg Ala 
            340                 345                 350         


Phe Tyr Arg Ile Gln Ala Thr Arg Met Met Thr Gly Ala Gly Asn Ile 
        355                 360                 365             


Leu Lys Lys His Ala Ala Glu Gln Ala Lys Lys Ala Ser Ser Met Ser 
    370                 375                 380                 


Glu Val His Thr Asp Glu Pro Glu Asp Phe Ile Ser Lys Val Phe Phe 
385                 390                 395                 400 


Asp Pro Cys Ser Tyr Gln Cys Leu Glu Asn Cys Gly Ala Val Leu Leu 
                405                 410                 415     


Thr Val Val Arg Lys Gly Gly Asp Met Ser Lys Thr Met Tyr Val Asp 
            420                 425                 430         


Tyr Lys Thr Glu Asp Gly Ser Ala Asn Ala Gly Ala Asp Tyr Glu Phe 
        435                 440                 445             


Thr Glu Gly Thr Val Val Leu Lys Pro Gly Glu Thr Gln Lys Glu Phe 
    450                 455                 460                 


Ser Val Gly Ile Ile Asp Asp Asp Ile Phe Glu Glu Asp Glu His Phe 
465                 470                 475                 480 


Phe Val Arg Leu Ser Asn Val Arg Ile Glu Glu Glu Gln Pro Glu Glu 
                485                 490                 495     


Gly Met Pro Pro Ala Ile Phe Asn Ser Leu Pro Leu Pro Arg Ala Val 
            500                 505                 510         


Leu Ala Ser Pro Cys Val Ala Thr Val Thr Ile Leu Asp Asp Asp His 
        515                 520                 525             


Ala Gly Ile Phe Thr Phe Glu Cys Asp Thr Ile His Val Ser Glu Ser 
    530                 535                 540                 


Ile Gly Val Met Glu Val Lys Val Leu Arg Thr Ser Gly Ala Arg Gly 
545                 550                 555                 560 


Thr Val Ile Val Pro Phe Arg Thr Val Glu Gly Thr Ala Lys Gly Gly 
                565                 570                 575     


Gly Glu Asp Phe Glu Asp Thr Tyr Gly Glu Leu Glu Phe Lys Asn Asp 
            580                 585                 590         


Glu Thr Val Lys Thr Ile His Ile Lys Val Ile Asp Asp Glu Ala Tyr 
        595                 600                 605             


Glu Lys Asn Lys Asn Tyr Phe Ile Glu Met Met Gly Pro Arg Met Val 
    610                 615                 620                 


Asp Met Ser Phe Gln Lys Ala Leu Leu Leu Ser Pro Asp Arg Lys Leu 
625                 630                 635                 640 


Thr Met Glu Glu Glu Glu Ala Lys Arg Ile Ala Glu Met Gly Lys Pro 
                645                 650                 655     


Val Leu Gly Glu His Pro Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr 
            660                 665                 670         


Glu Phe Lys Thr Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala 
        675                 680                 685             


Leu Val Val Gly Thr His Ser Trp Arg Asp Gln Phe Met Glu Ala Ile 
    690                 695                 700                 


Thr Val Ser Ala Ala Gly Asp Glu Asp Glu Asp Glu Ser Gly Glu Glu 
705                 710                 715                 720 


Arg Leu Pro Ser Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe 
                725                 730                 735     


Trp Lys Val Leu Phe Ala Cys Val Pro Pro Thr Glu Tyr Cys His Gly 
            740                 745                 750         


Trp Ala Cys Phe Ala Val Ser Ile Leu Ile Ile Gly Met Leu Thr Ala 
        755                 760                 765             


Ile Ile Gly Asp Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys 
    770                 775                 780                 


Asp Ser Val Thr Ala Val Val Phe Val Ala Phe Gly Thr Ser Val Pro 
785                 790                 795                 800 


Asp Thr Phe Ala Ser Lys Ala Ala Ala Leu Gln Asp Val Tyr Ala Asp 
                805                 810                 815     


Ala Ser Ile Gly Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu 
            820                 825                 830         


Gly Ile Gly Leu Ala Trp Ser Val Ala Ala Ile Tyr Trp Ala Leu Gln 
        835                 840                 845             


Gly Gln Glu Phe His Val Ser Ala Gly Thr Leu Ala Phe Ser Val Thr 
    850                 855                 860                 


Leu Phe Thr Ile Phe Ala Phe Val Cys Ile Ser Val Leu Leu Tyr Arg 
865                 870                 875                 880 


Arg Arg Pro His Leu Gly Gly Glu Leu Gly Gly Pro Arg Gly Cys Lys 
                885                 890                 895     


Leu Ala Thr Thr Trp Leu Phe Val Ser Leu Trp Leu Leu Tyr Ile Leu 
            900                 905                 910         


Phe Ala Thr Leu Glu Ala Tyr Cys Tyr Ile Lys Gly Phe 
        915                 920                 925 


<210>  499
<211>  924
<212>  PRT
<213>  Homo sapiens

<400>  499

Met Ala Trp Leu Arg Leu Gln Pro Leu Thr Ser Ala Phe Leu His Phe 
1               5                   10                  15      


Gly Leu Val Thr Phe Val Leu Phe Leu Asn Gly Leu Arg Ala Glu Ala 
            20                  25                  30          


Gly Gly Ser Gly Asp Val Pro Ser Thr Gly Gln Asn Asn Glu Ser Cys 
        35                  40                  45              


Ser Gly Ser Ser Asp Cys Lys Glu Gly Val Ile Leu Pro Ile Trp Tyr 
    50                  55                  60                  


Pro Glu Asn Pro Ser Leu Gly Asp Lys Ile Ala Arg Val Ile Val Tyr 
65                  70                  75                  80  


Phe Val Ala Leu Ile Tyr Met Phe Leu Gly Val Ser Ile Ile Ala Asp 
                85                  90                  95      


Arg Phe Met Ala Ser Ile Glu Val Ile Thr Ser Gln Glu Arg Glu Val 
            100                 105                 110         


Thr Ile Lys Lys Pro Asn Gly Glu Thr Ser Thr Thr Thr Ile Arg Val 
        115                 120                 125             


Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser Ser 
    130                 135                 140                 


Ala Pro Glu Ile Leu Leu Ser Leu Ile Glu Val Cys Gly His Gly Phe 
145                 150                 155                 160 


Ile Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala Phe 
                165                 170                 175     


Asn Met Phe Ile Ile Ile Gly Ile Cys Val Tyr Val Ile Pro Asp Gly 
            180                 185                 190         


Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Ile Thr Ala Ala 
        195                 200                 205             


Trp Ser Ile Phe Ala Tyr Ile Trp Leu Tyr Met Ile Leu Ala Val Phe 
    210                 215                 220                 


Ser Pro Gly Val Val Gln Val Trp Glu Gly Leu Leu Thr Leu Phe Phe 
225                 230                 235                 240 


Phe Pro Val Cys Val Leu Leu Ala Trp Val Ala Asp Lys Arg Leu Leu 
                245                 250                 255     


Phe Tyr Lys Tyr Met His Lys Lys Tyr Arg Thr Asp Lys His Arg Gly 
            260                 265                 270         


Ile Ile Ile Glu Thr Glu Gly Asp His Pro Lys Gly Ile Glu Met Asp 
        275                 280                 285             


Gly Lys Met Met Asn Ser His Phe Leu Asp Gly Asn Leu Val Pro Leu 
    290                 295                 300                 


Glu Gly Lys Glu Val Asp Glu Ser Arg Arg Glu Met Ile Arg Ile Leu 
305                 310                 315                 320 


Lys Asp Leu Lys Gln Lys His Pro Glu Lys Asp Leu Asp Gln Leu Val 
                325                 330                 335     


Glu Met Ala Asn Tyr Tyr Ala Leu Ser His Gln Gln Lys Ser Arg Ala 
            340                 345                 350         


Phe Tyr Arg Ile Gln Ala Thr Arg Met Met Thr Gly Ala Gly Asn Ile 
        355                 360                 365             


Leu Lys Lys His Ala Ala Glu Gln Ala Lys Lys Ala Ser Ser Met Ser 
    370                 375                 380                 


Glu Val His Thr Asp Glu Pro Glu Asp Phe Ile Ser Lys Val Phe Phe 
385                 390                 395                 400 


Asp Pro Cys Ser Tyr Gln Cys Leu Glu Asn Cys Gly Ala Val Leu Leu 
                405                 410                 415     


Thr Val Val Arg Lys Gly Gly Asp Met Ser Lys Thr Met Tyr Val Asp 
            420                 425                 430         


Tyr Lys Thr Glu Asp Gly Ser Ala Asn Ala Gly Ala Asp Tyr Glu Phe 
        435                 440                 445             


Thr Glu Gly Thr Val Val Leu Lys Pro Gly Glu Thr Gln Lys Glu Phe 
    450                 455                 460                 


Ser Val Gly Ile Ile Asp Asp Asp Ile Phe Glu Glu Asp Glu His Phe 
465                 470                 475                 480 


Phe Val Arg Leu Ser Asn Val Arg Ile Glu Glu Glu Gln Pro Glu Glu 
                485                 490                 495     


Gly Met Pro Pro Ala Ile Phe Asn Ser Leu Pro Leu Pro Arg Ala Val 
            500                 505                 510         


Leu Ala Ser Pro Cys Val Ala Thr Val Thr Ile Leu Asp Asp Asp His 
        515                 520                 525             


Ala Gly Ile Phe Thr Phe Glu Cys Asp Thr Ile His Val Ser Glu Ser 
    530                 535                 540                 


Ile Gly Val Met Glu Val Lys Val Leu Arg Thr Ser Gly Ala Arg Gly 
545                 550                 555                 560 


Thr Val Ile Val Pro Phe Arg Thr Val Glu Gly Thr Ala Lys Gly Gly 
                565                 570                 575     


Gly Glu Asp Phe Glu Asp Thr Tyr Gly Glu Leu Glu Phe Lys Asn Asp 
            580                 585                 590         


Glu Thr Val Lys Thr Ile Arg Val Lys Ile Val Asp Glu Glu Glu Tyr 
        595                 600                 605             


Glu Arg Gln Glu Asn Phe Phe Ile Ala Leu Gly Glu Pro Lys Trp Met 
    610                 615                 620                 


Glu Arg Gly Ile Ser Ala Leu Leu Leu Ser Pro Asp Arg Lys Leu Thr 
625                 630                 635                 640 


Met Glu Glu Glu Glu Ala Lys Arg Ile Ala Glu Met Gly Lys Pro Val 
                645                 650                 655     


Leu Gly Glu His Pro Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr Glu 
            660                 665                 670         


Phe Lys Thr Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala Leu 
        675                 680                 685             


Val Val Gly Thr His Ser Trp Arg Asp Gln Phe Met Glu Ala Ile Thr 
    690                 695                 700                 


Val Ser Ala Ala Gly Asp Glu Asp Glu Asp Glu Ser Gly Glu Glu Arg 
705                 710                 715                 720 


Leu Pro Ser Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp 
                725                 730                 735     


Lys Val Leu Phe Ala Cys Val Pro Pro Thr Glu Tyr Cys His Gly Trp 
            740                 745                 750         


Ala Cys Phe Ala Val Ser Ile Leu Ile Ile Gly Met Leu Thr Ala Ile 
        755                 760                 765             


Ile Gly Asp Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys Asp 
    770                 775                 780                 


Ser Val Thr Ala Val Val Phe Val Ala Phe Gly Thr Ser Val Pro Asp 
785                 790                 795                 800 


Thr Phe Ala Ser Lys Ala Ala Ala Leu Gln Asp Val Tyr Ala Asp Ala 
                805                 810                 815     


Ser Ile Gly Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly 
            820                 825                 830         


Ile Gly Leu Ala Trp Ser Val Ala Ala Ile Tyr Trp Ala Leu Gln Gly 
        835                 840                 845             


Gln Glu Phe His Val Ser Ala Gly Thr Leu Ala Phe Ser Val Thr Leu 
    850                 855                 860                 


Phe Thr Ile Phe Ala Phe Val Cys Ile Ser Val Leu Leu Tyr Arg Arg 
865                 870                 875                 880 


Arg Pro His Leu Gly Gly Glu Leu Gly Gly Pro Arg Gly Cys Lys Leu 
                885                 890                 895     


Ala Thr Thr Trp Leu Phe Val Ser Leu Trp Leu Leu Tyr Ile Leu Phe 
            900                 905                 910         


Ala Thr Leu Glu Ala Tyr Cys Tyr Ile Lys Gly Phe 
        915                 920                 


<210>  500
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  500

Met Ala Trp Leu Arg Leu Gln Pro Leu Thr Ser Ala Phe Leu His Phe 
1               5                   10                  15      


Gly Leu Val Thr Phe Val Leu Phe Leu Asn Gly Leu Arg Ala Glu Ala 
            20                  25                  30          


Gly Gly Ser Gly Asp Val Pro Ser Thr Gly Gln Asn Asn Glu Ser Cys 
        35                  40                  45              


Ser Gly Ser Ser Asp Cys Lys Glu Gly Val Ile Leu Pro Ile Trp Tyr 
    50                  55                  60                  


Pro Glu Asn Pro Ser Leu Gly Asp Lys Ile Ala Arg Val Ile Val Tyr 
65                  70                  75                  80  


Phe Val Ala Leu Ile Tyr Met Phe Leu Gly Val Ser Ile Ile Ala Asp 
                85                  90                  95      


Arg Phe Met Ala Ser Ile Glu Val Ile Thr Ser Gln Glu Arg Glu Val 
            100                 105                 110         


Thr Ile Lys Lys Pro Asn Gly Glu Thr Ser Thr Thr Thr Ile Arg Val 
        115                 120                 125             


Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser Ser 
    130                 135                 140                 


Ala Pro Glu Ile Leu Leu Ser Leu Ile Glu Val Cys Gly His Gly Phe 
145                 150                 155                 160 


Ile Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala Phe 
                165                 170                 175     


Asn Met Phe Ile Ile Ile Gly Ile Cys Val Tyr Val Ile Pro Asp Gly 
            180                 185                 190         


Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Ile Thr Ala Ala 
        195                 200                 205             


Trp Ser Ile Phe Ala Tyr Ile Trp Leu Tyr Met Ile Leu Ala Val Phe 
    210                 215                 220                 


Ser Pro Gly Val Val Gln Val Trp Glu Gly Leu Leu Thr Leu Phe Phe 
225                 230                 235                 240 


Phe Pro Val Cys Val Leu Leu Ala Trp Val Ala Asp Lys Arg Leu Leu 
                245                 250                 255     


Phe Tyr Lys Tyr Met His Lys Lys Tyr Arg Thr Asp Lys His Arg Gly 
            260                 265                 270         


Ile Ile Ile Glu Thr Glu Gly Asp His Pro Lys Gly Ile Glu Met Asp 
        275                 280                 285             


Gly Lys Met Met Asn Ser His Phe Leu Asp Gly Asn Leu Val Pro Leu 
    290                 295                 300                 


Glu Gly Lys Glu Val Asp Glu Ser Arg Arg Glu Met Ile Arg Ile Leu 
305                 310                 315                 320 


Lys Asp Leu Lys Gln Lys His Pro Glu Lys Asp Leu Asp Gln Leu Val 
                325                 330                 335     


Glu Met Ala Asn Tyr Tyr Ala Leu Ser His Gln Gln Lys Ser Arg Ala 
            340                 345                 350         


Phe Tyr Arg Ile Gln Ala Thr Arg Met Met Thr Gly Ala Gly Asn Ile 
        355                 360                 365             


Leu Lys Lys His Ala Ala Glu Gln Ala Lys Lys Ala Ser Ser Met Ser 
    370                 375                 380                 


Glu Val His Thr Asp Glu Pro Glu Asp Phe Ile Ser Lys Val Phe Phe 
385                 390                 395                 400 


Asp Pro Cys Ser Tyr Gln Cys Leu Glu Asn Cys Gly Ala Val Leu Leu 
                405                 410                 415     


Thr Val Val Arg Lys Gly Gly Asp Met Ser Lys Thr Met Tyr Val Asp 
            420                 425                 430         


Tyr Lys Thr Glu Asp Gly Ser Ala Asn Ala Gly Ala Asp Tyr Glu Phe 
        435                 440                 445             


Thr Glu Gly Thr Val Val Leu Lys Pro Gly Glu Thr Gln Lys Glu Phe 
    450                 455                 460                 


Ser Val Gly Ile Ile Asp Asp Asp Ile Phe Glu Glu Asp Glu His Phe 
465                 470                 475                 480 


Phe Val Arg Leu Ser Asn Val Arg Ile Glu Glu Glu Gln Pro Glu Glu 
                485                 490                 495     


Gly Met Pro Pro Ala Ile Phe Asn Ser Leu Pro Leu Pro Arg Ala Val 
            500                 505                 510         


Leu Ala Ser Pro Cys Val Ala Thr Val Thr Ile Leu Asp Asp Asp His 
        515                 520                 525             


Ala Gly Ile Phe Thr Phe Glu Cys Asp Thr Ile His Val Ser Glu Ser 
    530                 535                 540                 


Ile Gly Val Met Glu Val Lys Val Leu Arg Thr Ser Gly Ala Arg Gly 
545                 550                 555                 560 


Thr Val Ile Val Pro Phe Arg Thr Val Glu Gly Thr Ala Lys Gly Gly 
                565                 570                 575     


Gly Glu Asp Phe Glu Asp Thr Tyr Gly Glu Leu Glu Phe Lys Asn Asp 
            580                 585                 590         


Glu Thr Val Lys Thr Ile Arg Val Lys Ile Val Asp Glu Glu Glu Tyr 
        595                 600                 605             


Glu Arg Gln Glu Asn Phe Phe Ile Ala Leu Gly Glu Pro Lys Trp Met 
    610                 615                 620                 


Glu Arg Gly Ile Ser Asp Val Thr Asp Arg Lys Leu Thr Met Glu Glu 
625                 630                 635                 640 


Glu Glu Ala Lys Arg Ile Ala Glu Met Gly Lys Pro Val Leu Gly Glu 
                645                 650                 655     


His Pro Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr Glu Phe Lys Thr 
            660                 665                 670         


Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala Leu Val Val Gly 
        675                 680                 685             


Thr His Ser Trp Arg Asp Gln Phe Met Glu Ala Ile Thr Val Ser Ala 
    690                 695                 700                 


Ala Gly Asp Glu Asp Glu Asp Glu Ser Gly Glu Glu Arg Leu Pro Ser 
705                 710                 715                 720 


Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp Lys Val Leu 
                725                 730                 735     


Phe Ala Cys Val Pro Pro Thr Glu Tyr Cys His Gly Trp Ala Cys Phe 
            740                 745                 750         


Ala Val Ser Ile Leu Ile Ile Gly Met Leu Thr Ala Ile Ile Gly Asp 
        755                 760                 765             


Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys Asp Ser Val Thr 
    770                 775                 780                 


Ala Val Val Phe Val Ala Phe Gly Thr Ser Val Pro Asp Thr Phe Ala 
785                 790                 795                 800 


Ser Lys Ala Ala Ala Leu Gln Asp Val Tyr Ala Asp Ala Ser Ile Gly 
                805                 810                 815     


Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly Ile Gly Leu 
            820                 825                 830         


Ala Trp Ser Val Ala Ala Ile Tyr Trp Ala Leu Gln Gly Gln Glu Phe 
        835                 840                 845             


His Val Ser Ala Gly Thr Leu Ala Phe Ser Val Thr Leu Phe Thr Ile 
    850                 855                 860                 


Phe Ala Phe Val Cys Ile Ser Val Leu Leu Tyr Arg Arg Arg Pro His 
865                 870                 875                 880 


Leu Gly Gly Glu Leu Gly Gly Pro Arg Gly Cys Lys Leu Ala Thr Thr 
                885                 890                 895     


Trp Leu Phe Val Ser Leu Trp Leu Leu Tyr Ile Leu Phe Ala Thr Leu 
            900                 905                 910         


Glu Ala Tyr Cys Tyr Ile Lys Gly Phe 
        915                 920     


<210>  501
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  501

Met Glu Glu Glu Glu Ala Lys Arg Ile Ala Glu Met Gly Lys Pro Val 
1               5                   10                  15      


Leu Gly Glu His Pro Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr Glu 
            20                  25                  30          


Phe Lys Thr Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala Leu 
        35                  40                  45              


Val Val Gly Thr His Ser Trp Arg Asp Gln Phe Met Glu Ala Ile Thr 
    50                  55                  60                  


Val Ser Ala Ala Gly Asp Glu Asp Glu Asp Glu Ser Gly Glu Glu Arg 
65                  70                  75                  80  


Leu Pro Ser Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp 
                85                  90                  95      


Lys Val Leu Phe Ala Cys Val Pro Pro Thr Glu Tyr Cys His Gly Trp 
            100                 105                 110         


Ala Cys Phe Ala Val Ser Ile Leu Ile Ile Gly Met Leu Thr Ala Ile 
        115                 120                 125             


Ile Gly Asp Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys Asp 
    130                 135                 140                 


Ser Val Thr Ala Val Val Phe Val Ala Phe Gly Thr Ser Val Pro Asp 
145                 150                 155                 160 


Thr Phe Ala Ser Lys Ala Ala Ala Leu Gln Asp Val Tyr Ala Asp Ala 
                165                 170                 175     


Ser Ile Gly Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly 
            180                 185                 190         


Ile Gly Leu Ala Trp Ser Val Ala Ala Ile Tyr Trp Ala Leu Gln Gly 
        195                 200                 205             


Gln Glu Phe His Val Ser Ala Gly Thr Leu Ala Phe Ser Val Thr Leu 
    210                 215                 220                 


Phe Thr Ile Phe Ala Phe Val Cys Ile Ser Val Leu Leu Tyr Arg Arg 
225                 230                 235                 240 


Arg Pro His Leu Gly Gly Glu Leu Gly Gly Pro Arg Gly Cys Lys Leu 
                245                 250                 255     


Ala Thr Thr Trp Leu Phe Val Ser Leu Trp Leu Leu Tyr Ile Leu Phe 
            260                 265                 270         


Ala Thr Leu Glu Ala Tyr Cys Tyr Ile Lys Gly Phe 
        275                 280                 


<210>  502
<211>  927
<212>  PRT
<213>  Homo sapiens

<400>  502

Met Ala Trp Leu Arg Leu Gln Pro Leu Thr Ser Ala Phe Leu His Phe 
1               5                   10                  15      


Gly Leu Val Thr Phe Val Leu Phe Leu Asn Gly Leu Arg Ala Glu Ala 
            20                  25                  30          


Gly Gly Ser Gly Asp Val Pro Ser Thr Gly Gln Asn Asn Glu Ser Cys 
        35                  40                  45              


Ser Gly Ser Ser Asp Cys Lys Glu Gly Val Ile Leu Pro Ile Trp Tyr 
    50                  55                  60                  


Pro Glu Asn Pro Ser Leu Gly Asp Lys Ile Ala Arg Val Ile Val Tyr 
65                  70                  75                  80  


Phe Val Ala Leu Ile Tyr Met Phe Leu Gly Val Ser Ile Ile Ala Asp 
                85                  90                  95      


Arg Phe Met Ala Ser Ile Glu Val Ile Thr Ser Gln Glu Arg Glu Val 
            100                 105                 110         


Thr Ile Lys Lys Pro Asn Gly Glu Thr Ser Thr Thr Thr Ile Arg Val 
        115                 120                 125             


Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser Ser 
    130                 135                 140                 


Ala Pro Glu Ile Leu Leu Ser Leu Ile Glu Val Cys Gly His Gly Phe 
145                 150                 155                 160 


Ile Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala Phe 
                165                 170                 175     


Asn Met Phe Ile Ile Ile Gly Ile Cys Val Tyr Val Ile Pro Asp Gly 
            180                 185                 190         


Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Ile Thr Ala Ala 
        195                 200                 205             


Trp Ser Ile Phe Ala Tyr Ile Trp Leu Tyr Met Ile Leu Ala Val Phe 
    210                 215                 220                 


Ser Pro Gly Val Val Gln Val Trp Glu Gly Leu Leu Thr Leu Phe Phe 
225                 230                 235                 240 


Phe Pro Val Cys Val Leu Leu Ala Trp Val Ala Asp Lys Arg Leu Leu 
                245                 250                 255     


Phe Tyr Lys Tyr Met His Lys Lys Tyr Arg Thr Asp Lys His Arg Gly 
            260                 265                 270         


Ile Ile Ile Glu Thr Glu Gly Asp His Pro Lys Gly Ile Glu Met Asp 
        275                 280                 285             


Gly Lys Met Met Asn Ser His Phe Leu Asp Gly Asn Leu Val Pro Leu 
    290                 295                 300                 


Glu Gly Lys Glu Val Asp Glu Ser Arg Arg Glu Met Ile Arg Ile Leu 
305                 310                 315                 320 


Lys Asp Leu Lys Gln Lys His Pro Glu Lys Asp Leu Asp Gln Leu Val 
                325                 330                 335     


Glu Met Ala Asn Tyr Tyr Ala Leu Ser His Gln Gln Lys Ser Arg Ala 
            340                 345                 350         


Phe Tyr Arg Ile Gln Ala Thr Arg Met Met Thr Gly Ala Gly Asn Ile 
        355                 360                 365             


Leu Lys Lys His Ala Ala Glu Gln Ala Lys Lys Ala Ser Ser Met Ser 
    370                 375                 380                 


Glu Val His Thr Asp Glu Pro Glu Asp Phe Ile Ser Lys Val Phe Phe 
385                 390                 395                 400 


Asp Pro Cys Ser Tyr Gln Cys Leu Glu Asn Cys Gly Ala Val Leu Leu 
                405                 410                 415     


Thr Val Val Arg Lys Gly Gly Asp Met Ser Lys Thr Met Tyr Val Asp 
            420                 425                 430         


Tyr Lys Thr Glu Asp Gly Ser Ala Asn Ala Gly Ala Asp Tyr Glu Phe 
        435                 440                 445             


Thr Glu Gly Thr Val Val Leu Lys Pro Gly Glu Thr Gln Lys Glu Phe 
    450                 455                 460                 


Ser Val Gly Ile Ile Asp Asp Asp Ile Phe Glu Glu Asp Glu His Phe 
465                 470                 475                 480 


Phe Val Arg Leu Ser Asn Val Arg Ile Glu Glu Glu Gln Pro Glu Glu 
                485                 490                 495     


Gly Met Pro Pro Ala Ile Phe Asn Ser Leu Pro Leu Pro Arg Ala Val 
            500                 505                 510         


Leu Ala Ser Pro Cys Val Ala Thr Val Thr Ile Leu Asp Asp Asp His 
        515                 520                 525             


Ala Gly Ile Phe Thr Phe Glu Cys Asp Thr Ile His Val Ser Glu Ser 
    530                 535                 540                 


Ile Gly Val Met Glu Val Lys Val Leu Arg Thr Ser Gly Ala Arg Gly 
545                 550                 555                 560 


Thr Val Ile Val Pro Phe Arg Thr Val Glu Gly Thr Ala Lys Gly Gly 
                565                 570                 575     


Gly Glu Asp Phe Glu Asp Thr Tyr Gly Glu Leu Glu Phe Lys Asn Asp 
            580                 585                 590         


Glu Thr Val Lys Thr Ile Arg Val Lys Ile Val Asp Glu Glu Glu Tyr 
        595                 600                 605             


Glu Arg Gln Glu Asn Phe Phe Ile Ala Leu Gly Glu Pro Lys Trp Met 
    610                 615                 620                 


Glu Arg Gly Ile Ser Ala Leu Leu Leu Ser Pro Asp Val Thr Asp Arg 
625                 630                 635                 640 


Lys Leu Thr Met Glu Glu Glu Glu Ala Lys Arg Ile Ala Glu Met Gly 
                645                 650                 655     


Lys Pro Val Leu Gly Glu His Pro Lys Leu Glu Val Ile Ile Glu Glu 
            660                 665                 670         


Ser Tyr Glu Phe Lys Thr Thr Val Asp Lys Leu Ile Lys Lys Thr Asn 
        675                 680                 685             


Leu Ala Leu Val Val Gly Thr His Ser Trp Arg Asp Gln Phe Met Glu 
    690                 695                 700                 


Ala Ile Thr Val Ser Ala Ala Gly Asp Glu Asp Glu Asp Glu Ser Gly 
705                 710                 715                 720 


Glu Glu Arg Leu Pro Ser Cys Phe Asp Tyr Val Met His Phe Leu Thr 
                725                 730                 735     


Val Phe Trp Lys Val Leu Phe Ala Cys Val Pro Pro Thr Glu Tyr Cys 
            740                 745                 750         


His Gly Trp Ala Cys Phe Ala Val Ser Ile Leu Ile Ile Gly Met Leu 
        755                 760                 765             


Thr Ala Ile Ile Gly Asp Leu Ala Ser His Phe Gly Cys Thr Ile Gly 
    770                 775                 780                 


Leu Lys Asp Ser Val Thr Ala Val Val Phe Val Ala Phe Gly Thr Ser 
785                 790                 795                 800 


Val Pro Asp Thr Phe Ala Ser Lys Ala Ala Ala Leu Gln Asp Val Tyr 
                805                 810                 815     


Ala Asp Ala Ser Ile Gly Asn Val Thr Gly Ser Asn Ala Val Asn Val 
            820                 825                 830         


Phe Leu Gly Ile Gly Leu Ala Trp Ser Val Ala Ala Ile Tyr Trp Ala 
        835                 840                 845             


Leu Gln Gly Gln Glu Phe His Val Ser Ala Gly Thr Leu Ala Phe Ser 
    850                 855                 860                 


Val Thr Leu Phe Thr Ile Phe Ala Phe Val Cys Ile Ser Val Leu Leu 
865                 870                 875                 880 


Tyr Arg Arg Arg Pro His Leu Gly Gly Glu Leu Gly Gly Pro Arg Gly 
                885                 890                 895     


Cys Lys Leu Ala Thr Thr Trp Leu Phe Val Ser Leu Trp Leu Leu Tyr 
            900                 905                 910         


Ile Leu Phe Ala Thr Leu Glu Ala Tyr Cys Tyr Ile Lys Gly Phe 
        915                 920                 925         


<210>  503
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  503

Met Asp Gln Asn Gln His Leu Asn Lys Thr Ala Glu Ala Gln Pro Ser 
1               5                   10                  15      


Glu Asn Lys Lys Thr Arg Tyr Cys Asn Gly Leu Lys Met Phe Leu Ala 
            20                  25                  30          


Ala Leu Ser Leu Ser Phe Ile Ala Lys Thr Leu Gly Ala Ile Ile Met 
        35                  40                  45              


Lys Ser Ser Ile Ile His Ile Glu Arg Arg Phe Glu Ile Ser Ser Ser 
    50                  55                  60                  


Leu Val Gly Phe Ile Asp Gly Ser Phe Glu Ile Gly Asn Leu Leu Val 
65                  70                  75                  80  


Ile Val Phe Val Ser Tyr Phe Gly Ser Lys Leu His Arg Pro Lys Leu 
                85                  90                  95      


Ile Gly Ile Gly Cys Phe Ile Met Gly Ile Gly Gly Val Leu Thr Ala 
            100                 105                 110         


Leu Pro His Phe Phe Met Gly Tyr Tyr Arg Tyr Ser Lys Glu Thr Asn 
        115                 120                 125             


Ile Asn Ser Ser Glu Asn Ser Thr Ser Thr Leu Ser Thr Cys Leu Ile 
    130                 135                 140                 


Asn Gln Ile Leu Ser Leu Asn Arg Ala Ser Pro Glu Ile Val Gly Lys 
145                 150                 155                 160 


Gly Cys Leu Lys Glu Ser Gly Ser Tyr Met Trp Ile Tyr Val Phe Met 
                165                 170                 175     


Gly Asn Met Leu Arg Gly Ile Gly Glu Thr Pro Ile Val Pro Leu Gly 
            180                 185                 190         


Leu Ser Tyr Ile Asp Asp Phe Ala Lys Glu Gly His Ser Ser Leu Tyr 
        195                 200                 205             


Leu Gly Ile Leu Asn Ala Ile Ala Met Ile Gly Pro Ile Ile Gly Phe 
    210                 215                 220                 


Thr Leu Gly Ser Leu Phe Ser Lys Met Tyr Val Asp Ile Gly Tyr Val 
225                 230                 235                 240 


Asp Leu Ser Thr Ile Arg Ile Thr Pro Thr Asp Ser Arg Trp Val Gly 
                245                 250                 255     


Ala Trp Trp Leu Asn Phe Leu Val Ser Gly Leu Phe Ser Ile Ile Ser 
            260                 265                 270         


Ser Ile Pro Phe Phe Phe Leu Pro Gln Thr Pro Asn Lys Pro Gln Lys 
        275                 280                 285             


Glu Arg Lys Ala Ser Leu Ser Leu His Val Leu Glu Thr Asn Asp Glu 
    290                 295                 300                 


Lys Asp Gln Thr Ala Asn Leu Thr Asn Gln Gly Lys Asn Ile Thr Lys 
305                 310                 315                 320 


Asn Val Thr Gly Phe Phe Gln Ser Phe Lys Ser Ile Leu Thr Asn Pro 
                325                 330                 335     


Leu Tyr Val Met Phe Val Leu Leu Thr Leu Leu Gln Val Ser Ser Tyr 
            340                 345                 350         


Ile Gly Ala Phe Thr Tyr Val Phe Lys Tyr Val Glu Gln Gln Tyr Gly 
        355                 360                 365             


Gln Pro Ser Ser Lys Ala Asn Ile Leu Leu Gly Val Ile Thr Ile Pro 
    370                 375                 380                 


Ile Phe Ala Ser Gly Met Phe Leu Gly Gly Tyr Ile Ile Lys Lys Phe 
385                 390                 395                 400 


Lys Leu Asn Thr Val Gly Ile Ala Lys Phe Ser Cys Phe Thr Ala Val 
                405                 410                 415     


Met Ser Leu Ser Phe Tyr Leu Leu Tyr Phe Phe Ile Leu Cys Glu Asn 
            420                 425                 430         


Lys Ser Val Ala Gly Leu Thr Met Thr Tyr Asp Gly Asn Asn Pro Val 
        435                 440                 445             


Thr Ser His Arg Asp Val Pro Leu Ser Tyr Cys Asn Ser Asp Cys Asn 
    450                 455                 460                 


Cys Asp Glu Ser Gln Trp Glu Pro Val Cys Gly Asn Asn Gly Ile Thr 
465                 470                 475                 480 


Tyr Ile Ser Pro Cys Leu Ala Gly Cys Lys Ser Ser Ser Gly Asn Lys 
                485                 490                 495     


Lys Pro Ile Val Phe Tyr Asn Cys Ser Cys Leu Glu Val Thr Gly Leu 
            500                 505                 510         


Gln Asn Arg Asn Tyr Ser Ala His Leu Gly Glu Cys Pro Arg Asp Asp 
        515                 520                 525             


Ala Cys Thr Arg Lys Phe Tyr Phe Phe Val Ala Ile Gln Val Leu Asn 
    530                 535                 540                 


Leu Phe Phe Ser Ala Leu Gly Gly Thr Ser His Val Met Leu Ile Val 
545                 550                 555                 560 


Lys Ile Val Gln Pro Glu Leu Lys Ser Leu Ala Leu Gly Phe His Ser 
                565                 570                 575     


Met Val Ile Arg Ala Leu Gly Gly Ile Leu Ala Pro Ile Tyr Phe Gly 
            580                 585                 590         


Ala Leu Ile Asp Thr Thr Cys Ile Lys Trp Ser Thr Asn Asn Cys Gly 
        595                 600                 605             


Thr Arg Gly Ser Cys Arg Thr Tyr Asn Ser Thr Ser Phe Ser Arg Val 
    610                 615                 620                 


Tyr Leu Gly Leu Ser Ser Met Leu Arg Val Ser Ser Leu Val Leu Tyr 
625                 630                 635                 640 


Ile Ile Leu Ile Tyr Ala Met Lys Lys Lys Tyr Gln Glu Lys Asp Ile 
                645                 650                 655     


Asn Ala Ser Glu Asn Gly Ser Val Met Asp Glu Ala Asn Leu Glu Ser 
            660                 665                 670         


Leu Asn Lys Asn Lys His Phe Val Pro Ser Ala Gly Ala Asp Ser Glu 
        675                 680                 685             


Thr His Cys 
    690     


<210>  504
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  504

Met Lys Ser Ala Lys Gly Ile Glu Asn Leu Ala Phe Val Pro Ser Ser 
1               5                   10                  15      


Pro Asp Ile Leu Arg Arg Leu Ser Ala Ser Pro Ser Gln Ile Glu Val 
            20                  25                  30          


Ser Ala Leu Ser Ser Asp Pro Gln Arg Glu Asn Ser Gln Pro Gln Glu 
        35                  40                  45              


Leu Gln Lys Pro Gln Glu Pro Gln Lys Ser Pro Glu Pro Ser Leu Pro 
    50                  55                  60                  


Ser Ala Pro Pro Asn Val Ser Glu Glu Lys Leu Arg Ser Leu Ser Leu 
65                  70                  75                  80  


Ser Glu Phe Glu Glu Gly Ser Tyr Gly Trp Arg Asn Phe His Pro Gln 
                85                  90                  95      


Cys Leu Gln Arg Cys Asn Thr Pro Gly Gly Phe Leu Leu His Tyr Cys 
            100                 105                 110         


Leu Leu Ala Val Thr Gln Gly Ile Val Val Asn Gly Leu Val Asn Ile 
        115                 120                 125             


Ser Ile Ser Thr Val Glu Lys Arg Tyr Glu Met Lys Ser Ser Leu Thr 
    130                 135                 140                 


Gly Leu Ile Ser Ser Ser Tyr Asp Ile Ser Phe Cys Leu Leu Ser Leu 
145                 150                 155                 160 


Phe Val Ser Phe Phe Gly Glu Arg Gly His Lys Pro Arg Trp Leu Ala 
                165                 170                 175     


Phe Ala Ala Phe Met Ile Gly Leu Gly Ala Leu Val Phe Ser Leu Pro 
            180                 185                 190         


Gln Phe Phe Ser Gly Glu Tyr Lys Leu Gly Ser Leu Phe Glu Asp Thr 
        195                 200                 205             


Cys Val Thr Thr Arg Asn Ser Thr Ser Cys Thr Ser Ser Thr Ser Ser 
    210                 215                 220                 


Leu Ser Asn Tyr Leu Tyr Val Phe Ile Leu Gly Gln Leu Leu Leu Gly 
225                 230                 235                 240 


Ala Gly Gly Thr Pro Leu Tyr Thr Leu Gly Thr Ala Phe Leu Asp Asp 
                245                 250                 255     


Ser Val Pro Thr His Lys Ser Ser Leu Tyr Ile Gly Thr Gly Tyr Ala 
            260                 265                 270         


Met Ser Ile Leu Gly Pro Ala Ile Gly Tyr Val Leu Gly Gly Gln Leu 
        275                 280                 285             


Leu Thr Ile Tyr Ile Asp Val Ala Met Gly Glu Ser Thr Asp Val Thr 
    290                 295                 300                 


Glu Asp Asp Pro Arg Trp Leu Gly Ala Trp Trp Ile Gly Phe Leu Leu 
305                 310                 315                 320 


Ser Trp Ile Phe Ala Trp Ser Leu Ile Ile Pro Phe Ser Cys Phe Pro 
                325                 330                 335     


Lys His Leu Pro Gly Thr Ala Glu Ile Gln Ala Gly Lys Thr Ser Gln 
            340                 345                 350         


Ala His Gln Ser Asn Ser Asn Ala Asp Val Lys Phe Gly Lys Ser Ile 
        355                 360                 365             


Lys Asp Phe Pro Ala Ala Leu Lys Asn Leu Met Lys Asn Ala Val Phe 
    370                 375                 380                 


Met Cys Leu Val Leu Ser Thr Ser Ser Glu Ala Leu Ile Thr Thr Gly 
385                 390                 395                 400 


Phe Ala Thr Phe Leu Pro Lys Phe Ile Glu Asn Gln Phe Gly Leu Thr 
                405                 410                 415     


Ser Ser Phe Ala Ala Thr Leu Gly Gly Ala Val Leu Ile Pro Gly Ala 
            420                 425                 430         


Ala Leu Gly Gln Ile Leu Gly Gly Phe Leu Val Ser Lys Phe Arg Met 
        435                 440                 445             


Thr Cys Lys Asn Thr Met Lys Phe Ala Leu Phe Thr Ser Gly Val Ala 
    450                 455                 460                 


Leu Thr Leu Ser Phe Val Phe Met Tyr Ala Lys Cys Glu Asn Glu Pro 
465                 470                 475                 480 


Phe Ala Gly Val Ser Glu Ser Tyr Asn Gly Thr Gly Glu Leu Gly Asn 
                485                 490                 495     


Leu Ile Ala Pro Cys Asn Ala Asn Cys Asn Cys Ser Arg Ser Tyr Tyr 
            500                 505                 510         


Tyr Pro Val Cys Gly Asp Gly Val Gln Tyr Phe Ser Pro Cys Phe Ala 
        515                 520                 525             


Gly Cys Ser Asn Pro Val Ala His Arg Lys Pro Lys Val Tyr Tyr Asn 
    530                 535                 540                 


Cys Ser Cys Ile Glu Arg Lys Thr Glu Ile Thr Ser Thr Ala Glu Thr 
545                 550                 555                 560 


Phe Gly Phe Glu Ala Lys Ala Gly Lys Cys Glu Thr His Cys Ala Lys 
                565                 570                 575     


Leu Pro Ile Phe Leu Cys Ile Phe Phe Ile Val Ile Ile Phe Thr Phe 
            580                 585                 590         


Met Ala Gly Thr Pro Ile Thr Val Ser Ile Leu Arg Cys Val Asn His 
        595                 600                 605             


Arg Gln Arg Ser Leu Ala Leu Gly Ile Gln Phe Met Val Leu Arg Leu 
    610                 615                 620                 


Leu Gly Thr Ile Pro Gly Pro Ile Ile Phe Gly Phe Thr Ile Asp Ser 
625                 630                 635                 640 


Thr Cys Ile Leu Trp Asp Ile Asn Asp Cys Gly Ile Lys Gly Ala Cys 
                645                 650                 655     


Trp Ile Tyr Asp Asn Ile Lys Met Ala His Met Leu Val Ala Ile Ser 
            660                 665                 670         


Val Thr Cys Lys Val Ile Thr Met Phe Phe Asn Gly Phe Ala Ile Phe 
        675                 680                 685             


Leu Tyr Lys Pro Pro Pro Ser Ala Thr Asp Val Ser Phe His Lys Glu 
    690                 695                 700                 


Asn Ala Val Val Thr Asn Val Leu Ala Glu Gln Asp Leu Asn Lys Ile 
705                 710                 715                 720 


Val Lys Glu Gly 
                


<210>  505
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  505

Met Asn Gly Asp Asp Thr Phe Ala Lys Arg Pro Arg Asp Asp Ala Lys 
1               5                   10                  15      


Ala Ser Glu Lys Arg Ser Lys Ala Phe Asp Asp Ile Ala Thr Tyr Phe 
            20                  25                  30          


Ser Lys Lys Glu Trp Lys Lys Met Lys Tyr Ser Glu Lys Ile Ser Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Asn Tyr Lys Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Val Thr Leu Pro Pro Phe Met Cys Asn Lys Gln Ala Thr Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Phe Asp Asn Asp His Asn Arg Arg Ile Gln Val Glu His 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu His Arg Ile Ile Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Asp Glu Asn Asp Ser Lys Gly Val Ser Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu His Pro Pro Gly Lys 
    130                 135                 140                 


Ala Asn Ile Ser Glu Lys Ile Asn Lys Arg Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210>  506
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  506

Met Asn Gly Asp Asp Thr Phe Ala Lys Arg Pro Arg Asp Asp Ala Lys 
1               5                   10                  15      


Ala Ser Glu Lys Arg Ser Lys Ala Phe Asp Asp Ile Ala Thr Tyr Phe 
            20                  25                  30          


Ser Lys Lys Glu Trp Lys Lys Met Lys Tyr Ser Glu Lys Ile Ser Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Asn Tyr Lys Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Val Thr Leu Pro Pro Phe Met Cys Asn Lys Gln Ala Thr Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Phe Asp Asn Asp His Asn Arg Arg Ile Gln Val Glu His 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu His Arg Ile Ile Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Asp Glu Asn Asp Ser Lys Gly Val Ser Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu His Pro Pro Gly Lys 
    130                 135                 140                 


Ala Asn Ile Ser Glu Lys Ile Asn Lys Arg Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210>  507
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  507

Met Ala Ser Val Pro Met Pro Ser Glu Tyr Thr Tyr Val Lys Leu Arg 
1               5                   10                  15      


Ser Asp Cys Ser Arg Pro Ser Leu Gln Trp Tyr Thr Arg Ala Gln Ser 
            20                  25                  30          


Lys Met Arg Arg Pro Ser Leu Leu Leu Lys Asp Ile Leu Lys Cys Thr 
        35                  40                  45              


Leu Leu Val Phe Gly Val Trp Ile Leu Tyr Ile Leu Lys Leu Asn Tyr 
    50                  55                  60                  


Thr Thr Glu Glu Cys Asp Met Lys Lys Met His Tyr Val Asp Pro Asp 
65                  70                  75                  80  


His Val Lys Arg Ala Gln Lys Tyr Ala Gln Gln Val Leu Gln Lys Glu 
                85                  90                  95      


Cys Arg Pro Lys Phe Ala Lys Thr Ser Met Ala Leu Leu Phe Glu His 
            100                 105                 110         


Arg Tyr Ser Val Asp Leu Leu Pro Phe Val Gln Lys Ala Pro Lys Asp 
        115                 120                 125             


Ser Glu Ala Glu Ser Lys Tyr Asp Pro Pro Phe Gly Phe Arg Lys Phe 
    130                 135                 140                 


Ser Ser Lys Val Gln Thr Leu Leu Glu Leu Leu Pro Glu His Asp Leu 
145                 150                 155                 160 


Pro Glu His Leu Lys Ala Lys Thr Cys Arg Arg Cys Val Val Ile Gly 
                165                 170                 175     


Ser Gly Gly Ile Leu His Gly Leu Glu Leu Gly His Thr Leu Asn Gln 
            180                 185                 190         


Phe Asp Val Val Ile Arg Leu Asn Ser Ala Pro Val Glu Gly Tyr Ser 
        195                 200                 205             


Glu His Val Gly Asn Lys Thr Thr Ile Arg Met Thr Tyr Pro Glu Gly 
    210                 215                 220                 


Ala Pro Leu Ser Asp Leu Glu Tyr Tyr Ser Asn Asp Leu Phe Val Ala 
225                 230                 235                 240 


Val Leu Phe Lys Ser Val Asp Phe Asn Trp Leu Gln Ala Met Val Lys 
                245                 250                 255     


Lys Glu Thr Leu Pro Phe Trp Val Arg Leu Phe Phe Trp Lys Gln Val 
            260                 265                 270         


Ala Glu Lys Ile Pro Leu Gln Pro Lys His Phe Arg Ile Leu Asn Pro 
        275                 280                 285             


Val Ile Ile Lys Glu Thr Ala Phe Asp Ile Leu Gln Tyr Ser Glu Pro 
    290                 295                 300                 


Gln Ser Arg Phe Trp Gly Arg Asp Lys Asn Val Pro Thr Ile Gly Val 
305                 310                 315                 320 


Ile Ala Val Val Leu Ala Thr His Leu Cys Asp Glu Val Ser Leu Ala 
                325                 330                 335     


Gly Phe Gly Tyr Asp Leu Asn Gln Pro Arg Thr Pro Leu His Tyr Phe 
            340                 345                 350         


Asp Ser Gln Cys Met Ala Ala Met Asn Phe Gln Thr Met His Asn Val 
        355                 360                 365             


Thr Thr Glu Thr Lys Phe Leu Leu Lys Leu Val Lys Glu Gly Val Val 
    370                 375                 380                 


Lys Asp Leu Ser Gly Gly Ile Asp Arg Glu Phe 
385                 390                 395 


<210>  508
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  508

Met Arg Thr Lys Ala Ala Gly Cys Ala Glu Arg Arg Pro Leu Gln Pro 
1               5                   10                  15      


Arg Thr Glu Ala Ala Ala Ala Pro Ala Gly Arg Ala Met Pro Ser Glu 
            20                  25                  30          


Tyr Thr Tyr Val Lys Leu Arg Ser Asp Cys Ser Arg Pro Ser Leu Gln 
        35                  40                  45              


Trp Tyr Thr Arg Ala Gln Ser Lys Met Arg Arg Pro Ser Leu Leu Leu 
    50                  55                  60                  


Lys Asp Ile Leu Lys Cys Thr Leu Leu Val Phe Gly Val Trp Ile Leu 
65                  70                  75                  80  


Tyr Ile Leu Lys Leu Asn Tyr Thr Thr Glu Glu Cys Asp Met Lys Lys 
                85                  90                  95      


Met His Tyr Val Asp Pro Asp His Val Lys Arg Ala Gln Lys Tyr Ala 
            100                 105                 110         


Gln Gln Val Leu Gln Lys Glu Cys Arg Pro Lys Phe Ala Lys Thr Ser 
        115                 120                 125             


Met Ala Leu Leu Phe Glu His Arg Tyr Ser Val Asp Leu Leu Pro Phe 
    130                 135                 140                 


Val Gln Lys Ala Pro Lys Asp Ser Glu Ala Glu Ser Lys Tyr Asp Pro 
145                 150                 155                 160 


Pro Phe Gly Phe Arg Lys Phe Ser Ser Lys Val Gln Thr Leu Leu Glu 
                165                 170                 175     


Leu Leu Pro Glu His Asp Leu Pro Glu His Leu Lys Ala Lys Thr Cys 
            180                 185                 190         


Arg Arg Cys Val Val Ile Gly Ser Gly Gly Ile Leu His Gly Leu Glu 
        195                 200                 205             


Leu Gly His Thr Leu Asn Gln Phe Asp Val Val Ile Arg Leu Asn Ser 
    210                 215                 220                 


Ala Pro Val Glu Gly Tyr Ser Glu His Val Gly Asn Lys Thr Thr Ile 
225                 230                 235                 240 


Arg Met Thr Tyr Pro Glu Gly Ala Pro Leu Ser Asp Leu Glu Tyr Tyr 
                245                 250                 255     


Ser Asn Asp Leu Phe Val Ala Val Leu Phe Lys Ser Val Asp Phe Asn 
            260                 265                 270         


Trp Leu Gln Ala Met Val Lys Lys Glu Thr Leu Pro Phe Trp Val Arg 
        275                 280                 285             


Leu Phe Phe Trp Lys Gln Val Ala Glu Lys Ile Pro Leu Gln Pro Lys 
    290                 295                 300                 


His Phe Arg Ile Leu Asn Pro Val Ile Ile Lys Glu Thr Ala Phe Asp 
305                 310                 315                 320 


Ile Leu Gln Tyr Ser Glu Pro Gln Ser Arg Phe Trp Gly Arg Asp Lys 
                325                 330                 335     


Asn Val Pro Thr Ile Gly Val Ile Ala Val Val Leu Ala Thr His Leu 
            340                 345                 350         


Cys Asp Glu Val Ser Leu Ala Gly Phe Gly Tyr Asp Leu Asn Gln Pro 
        355                 360                 365             


Arg Thr Pro Leu His Tyr Phe Asp Ser Gln Cys Met Ala Ala Met Asn 
    370                 375                 380                 


Phe Gln Thr Met His Asn Val Thr Thr Glu Thr Lys Phe Leu Leu Lys 
385                 390                 395                 400 


Leu Val Lys Glu Gly Val Val Lys Asp Leu Ser Gly Gly Ile Asp Arg 
                405                 410                 415     


Glu Phe 
        


<210>  509
<211>  2551
<212>  PRT
<213>  Homo sapiens

<400>  509

Met Met Leu Gln His Leu Val Ile Phe Cys Leu Gly Leu Val Val Gln 
1               5                   10                  15      


Asn Phe Cys Ser Pro Ala Glu Thr Thr Gly Gln Ala Arg Arg Cys Asp 
            20                  25                  30          


Arg Lys Ser Leu Leu Thr Ile Arg Thr Glu Cys Arg Ser Cys Ala Leu 
        35                  40                  45              


Asn Leu Gly Val Lys Cys Pro Asp Gly Tyr Thr Met Ile Thr Ser Gly 
    50                  55                  60                  


Ser Val Gly Val Arg Asp Cys Arg Tyr Thr Phe Glu Val Arg Thr Tyr 
65                  70                  75                  80  


Ser Leu Ser Leu Pro Gly Cys Arg His Ile Cys Arg Lys Asp Tyr Leu 
                85                  90                  95      


Gln Pro Arg Cys Cys Pro Gly Arg Trp Gly Pro Asp Cys Ile Glu Cys 
            100                 105                 110         


Pro Gly Gly Ala Gly Ser Pro Cys Asn Gly Arg Gly Ser Cys Ala Glu 
        115                 120                 125             


Gly Met Glu Gly Asn Gly Thr Cys Ser Cys Gln Glu Gly Phe Gly Gly 
    130                 135                 140                 


Thr Ala Cys Glu Thr Cys Ala Asp Asp Asn Leu Phe Gly Pro Ser Cys 
145                 150                 155                 160 


Ser Ser Val Cys Asn Cys Val His Gly Val Cys Asn Ser Gly Leu Asp 
                165                 170                 175     


Gly Asp Gly Thr Cys Glu Cys Tyr Ser Ala Tyr Thr Gly Pro Lys Cys 
            180                 185                 190         


Asp Lys Pro Ile Pro Glu Cys Ala Ala Leu Leu Cys Pro Glu Asn Ser 
        195                 200                 205             


Arg Cys Ser Pro Ser Thr Glu Asp Glu Asn Lys Leu Glu Cys Lys Cys 
    210                 215                 220                 


Leu Pro Asn Tyr Arg Gly Asp Gly Lys Tyr Cys Asp Pro Ile Asn Pro 
225                 230                 235                 240 


Cys Leu Arg Lys Ile Cys His Pro His Ala His Cys Thr Tyr Leu Gly 
                245                 250                 255     


Pro Asn Arg His Ser Cys Thr Cys Gln Glu Gly Tyr Arg Gly Asp Gly 
            260                 265                 270         


Gln Val Cys Leu Pro Val Asp Pro Cys Gln Ile Asn Phe Gly Asn Cys 
        275                 280                 285             


Pro Thr Lys Ser Thr Val Cys Lys Tyr Asp Gly Pro Gly Gln Ser His 
    290                 295                 300                 


Cys Glu Cys Lys Glu His Tyr Gln Asn Phe Val Pro Gly Val Gly Cys 
305                 310                 315                 320 


Ser Met Thr Asp Ile Cys Lys Ser Asp Asn Pro Cys His Arg Asn Ala 
                325                 330                 335     


Asn Cys Thr Thr Val Ala Pro Gly Arg Thr Glu Cys Ile Cys Gln Lys 
            340                 345                 350         


Gly Tyr Val Gly Asp Gly Leu Thr Cys Tyr Gly Asn Ile Met Glu Arg 
        355                 360                 365             


Leu Arg Glu Leu Asn Thr Glu Pro Arg Gly Lys Trp Gln Gly Arg Leu 
    370                 375                 380                 


Thr Ser Phe Ile Ser Leu Leu Asp Lys Ala Tyr Ala Trp Pro Leu Ser 
385                 390                 395                 400 


Lys Leu Gly Pro Phe Thr Val Leu Leu Pro Thr Asp Lys Gly Leu Lys 
                405                 410                 415     


Gly Phe Asn Val Asn Glu Leu Leu Val Asp Asn Lys Ala Ala Gln Tyr 
            420                 425                 430         


Phe Val Lys Leu His Ile Ile Ala Gly Gln Met Asn Ile Glu Tyr Met 
        435                 440                 445             


Asn Asn Thr Asp Met Phe Tyr Thr Leu Thr Gly Lys Ser Gly Glu Ile 
    450                 455                 460                 


Phe Asn Ser Asp Lys Asp Asn Gln Ile Lys Leu Lys Leu His Gly Gly 
465                 470                 475                 480 


Lys Lys Lys Val Lys Ile Ile Gln Gly Asp Ile Ile Ala Ser Asn Gly 
                485                 490                 495     


Leu Leu His Ile Leu Asp Arg Ala Met Asp Lys Leu Glu Pro Thr Phe 
            500                 505                 510         


Glu Ser Asn Asn Glu Gln Thr Ile Met Thr Met Leu Gln Pro Arg Tyr 
        515                 520                 525             


Ser Lys Phe Arg Ser Leu Leu Glu Glu Thr Asn Leu Gly His Ala Leu 
    530                 535                 540                 


Asp Glu Asp Gly Val Gly Gly Pro Tyr Thr Ile Phe Val Pro Asn Asn 
545                 550                 555                 560 


Glu Ala Leu Asn Asn Met Lys Asp Gly Thr Leu Asp Tyr Leu Leu Ser 
                565                 570                 575     


Pro Glu Gly Ser Arg Lys Leu Leu Glu Leu Val Arg Tyr His Ile Val 
            580                 585                 590         


Pro Phe Thr Gln Leu Glu Val Ala Thr Leu Ile Ser Thr Pro His Ile 
        595                 600                 605             


Arg Ser Met Ala Asn Gln Leu Ile Gln Phe Asn Thr Thr Asp Asn Gly 
    610                 615                 620                 


Gln Ile Leu Ala Asn Asp Val Ala Met Glu Glu Ile Glu Ile Thr Ala 
625                 630                 635                 640 


Lys Asn Gly Arg Ile Tyr Thr Leu Thr Gly Val Leu Ile Pro Pro Ser 
                645                 650                 655     


Ile Val Pro Ile Leu Pro His Arg Cys Asp Glu Thr Lys Arg Glu Met 
            660                 665                 670         


Lys Leu Gly Thr Cys Val Ser Cys Ser Leu Val Tyr Trp Ser Arg Cys 
        675                 680                 685             


Pro Ala Asn Ser Glu Pro Thr Ala Leu Phe Thr His Arg Cys Val Tyr 
    690                 695                 700                 


Ser Gly Arg Phe Gly Ser Leu Lys Ser Gly Cys Ala Arg Tyr Cys Asn 
705                 710                 715                 720 


Ala Thr Val Lys Ile Pro Lys Cys Cys Lys Gly Phe Tyr Gly Pro Asp 
                725                 730                 735     


Cys Asn Gln Cys Pro Gly Gly Phe Ser Asn Pro Cys Ser Gly Asn Gly 
            740                 745                 750         


Gln Cys Ala Asp Ser Leu Gly Gly Asn Gly Thr Cys Ile Cys Glu Glu 
        755                 760                 765             


Gly Phe Gln Gly Ser Gln Cys Gln Phe Cys Ser Asp Pro Asn Lys Tyr 
    770                 775                 780                 


Gly Pro Arg Cys Asn Lys Lys Cys Leu Cys Val His Gly Thr Cys Asn 
785                 790                 795                 800 


Asn Arg Ile Asp Ser Asp Gly Ala Cys Leu Thr Gly Thr Cys Arg Asp 
                805                 810                 815     


Gly Ser Ala Gly Arg Leu Cys Asp Lys Gln Thr Ser Ala Cys Gly Pro 
            820                 825                 830         


Tyr Val Gln Phe Cys His Ile His Ala Thr Cys Glu Tyr Ser Asn Gly 
        835                 840                 845             


Thr Ala Ser Cys Ile Cys Lys Ala Gly Tyr Glu Gly Asp Gly Thr Leu 
    850                 855                 860                 


Cys Ser Glu Met Asp Pro Cys Thr Gly Leu Thr Pro Gly Gly Cys Ser 
865                 870                 875                 880 


Arg Asn Ala Glu Cys Ile Lys Thr Gly Thr Gly Thr His Thr Cys Val 
                885                 890                 895     


Cys Gln Gln Gly Trp Thr Gly Asn Gly Arg Asp Cys Ser Glu Ile Asn 
            900                 905                 910         


Asn Cys Leu Leu Pro Ser Ala Gly Gly Cys His Asp Asn Ala Ser Cys 
        915                 920                 925             


Leu Tyr Val Gly Pro Gly Gln Asn Glu Cys Glu Cys Lys Lys Gly Phe 
    930                 935                 940                 


Arg Gly Asn Gly Ile Asp Cys Glu Pro Ile Thr Ser Cys Leu Glu Gln 
945                 950                 955                 960 


Thr Gly Lys Cys His Pro Leu Ala Ser Cys Gln Ser Thr Ser Ser Gly 
                965                 970                 975     


Val Trp Ser Cys Val Cys Gln Glu Gly Tyr Glu Gly Asp Gly Phe Leu 
            980                 985                 990         


Cys Tyr Gly Asn Ala Ala Val Glu  Leu Ser Phe Leu Ser  Glu Ala Ala 
        995                 1000                 1005             


Ile Phe  Asn Arg Trp Ile Asn  Asn Ala Ser Leu Gln  Pro Thr Leu 
    1010                 1015                 1020             


Ser Ala  Thr Ser Asn Leu Thr  Val Leu Val Pro Ser  Gln Gln Ala 
    1025                 1030                 1035             


Thr Glu  Asp Met Asp Gln Asp  Glu Lys Ser Phe Trp  Leu Ser Gln 
    1040                 1045                 1050             


Ser Asn  Ile Pro Ala Leu Ile  Lys Tyr His Met Leu  Leu Gly Thr 
    1055                 1060                 1065             


Tyr Arg  Val Ala Asp Leu Gln  Thr Leu Ser Ser Ser  Asp Met Leu 
    1070                 1075                 1080             


Ala Thr  Ser Leu Gln Gly Asn  Phe Leu His Leu Ala  Lys Val Asp 
    1085                 1090                 1095             


Gly Asn  Ile Thr Ile Glu Gly  Ala Ser Ile Val Asp  Gly Asp Asn 
    1100                 1105                 1110             


Ala Ala  Thr Asn Gly Val Ile  His Ile Ile Asn Lys  Val Leu Val 
    1115                 1120                 1125             


Pro Gln  Arg Arg Leu Thr Gly  Ser Leu Pro Asn Leu  Leu Met Arg 
    1130                 1135                 1140             


Leu Glu  Gln Met Pro Asp Tyr  Ser Ile Phe Arg Gly  Tyr Ile Ile 
    1145                 1150                 1155             


Gln Tyr  Asn Leu Ala Asn Ala  Ile Glu Ala Ala Asp  Ala Tyr Thr 
    1160                 1165                 1170             


Val Phe  Ala Pro Asn Asn Asn  Ala Ile Glu Asn Tyr  Ile Arg Glu 
    1175                 1180                 1185             


Lys Lys  Val Leu Ser Leu Glu  Glu Asp Val Leu Arg  Tyr His Val 
    1190                 1195                 1200             


Val Leu  Glu Glu Lys Leu Leu  Lys Asn Asp Leu His  Asn Gly Met 
    1205                 1210                 1215             


His Arg  Glu Thr Met Leu Gly  Phe Ser Tyr Phe Leu  Ser Phe Phe 
    1220                 1225                 1230             


Leu His  Asn Asp Gln Leu Tyr  Val Asn Glu Ala Pro  Ile Asn Tyr 
    1235                 1240                 1245             


Thr Asn  Val Ala Thr Asp Lys  Gly Val Ile His Gly  Leu Gly Lys 
    1250                 1255                 1260             


Val Leu  Glu Ile Gln Lys Asn  Arg Cys Asp Asn Asn  Asp Thr Thr 
    1265                 1270                 1275             


Ile Ile  Arg Gly Arg Cys Arg  Thr Cys Ser Ser Glu  Leu Thr Cys 
    1280                 1285                 1290             


Pro Phe  Gly Thr Lys Ser Leu  Gly Asn Glu Lys Arg  Arg Cys Ile 
    1295                 1300                 1305             


Tyr Thr  Ser Tyr Phe Met Gly  Arg Arg Thr Leu Phe  Ile Gly Cys 
    1310                 1315                 1320             


Gln Pro  Lys Cys Val Arg Thr  Val Ile Thr Arg Glu  Cys Cys Ala 
    1325                 1330                 1335             


Gly Phe  Phe Gly Pro Gln Cys  Gln Pro Cys Pro Gly  Asn Ala Gln 
    1340                 1345                 1350             


Asn Val  Cys Phe Gly Asn Gly  Ile Cys Leu Asp Gly  Val Asn Gly 
    1355                 1360                 1365             


Thr Gly  Val Cys Glu Cys Gly  Glu Gly Phe Ser Gly  Thr Ala Cys 
    1370                 1375                 1380             


Glu Thr  Cys Thr Glu Gly Lys  Tyr Gly Ile His Cys  Asp Gln Ala 
    1385                 1390                 1395             


Cys Ser  Cys Val His Gly Arg  Cys Asn Gln Gly Pro  Leu Gly Asp 
    1400                 1405                 1410             


Gly Ser  Cys Asp Cys Asp Val  Gly Trp Arg Gly Val  His Cys Asp 
    1415                 1420                 1425             


Asn Ala  Thr Thr Glu Asp Asn  Cys Asn Gly Thr Cys  His Thr Ser 
    1430                 1435                 1440             


Ala Asn  Cys Leu Thr Asn Ser  Asp Gly Thr Ala Ser  Cys Lys Cys 
    1445                 1450                 1455             


Ala Ala  Gly Phe Gln Gly Asn  Gly Thr Ile Cys Thr  Ala Ile Asn 
    1460                 1465                 1470             


Ala Cys  Glu Ile Ser Asn Gly  Gly Cys Ser Ala Lys  Ala Asp Cys 
    1475                 1480                 1485             


Lys Arg  Thr Thr Pro Gly Arg  Arg Val Cys Thr Cys  Lys Ala Gly 
    1490                 1495                 1500             


Tyr Thr  Gly Asp Gly Ile Val  Cys Leu Glu Ile Asn  Pro Cys Leu 
    1505                 1510                 1515             


Glu Asn  His Gly Gly Cys Asp  Lys Asn Ala Glu Cys  Thr Gln Thr 
    1520                 1525                 1530             


Gly Pro  Asn Gln Ala Ala Cys  Asn Cys Leu Pro Ala  Tyr Thr Gly 
    1535                 1540                 1545             


Asp Gly  Lys Val Cys Thr Leu  Ile Asn Val Cys Leu  Thr Lys Asn 
    1550                 1555                 1560             


Gly Gly  Cys Ser Glu Phe Ala  Ile Cys Asn His Thr  Gly Gln Val 
    1565                 1570                 1575             


Glu Arg  Thr Cys Thr Cys Lys  Pro Asn Tyr Ile Gly  Asp Gly Phe 
    1580                 1585                 1590             


Thr Cys  Arg Gly Ser Ile Tyr  Gln Glu Leu Pro Lys  Asn Pro Lys 
    1595                 1600                 1605             


Thr Ser  Gln Tyr Phe Phe Gln  Leu Gln Glu His Phe  Val Lys Asp 
    1610                 1615                 1620             


Leu Val  Gly Pro Gly Pro Phe  Thr Val Phe Ala Pro  Leu Ser Ala 
    1625                 1630                 1635             


Ala Phe  Asp Glu Glu Ala Arg  Val Lys Asp Trp Asp  Lys Tyr Gly 
    1640                 1645                 1650             


Leu Met  Pro Gln Val Leu Arg  Tyr His Val Val Ala  Cys His Gln 
    1655                 1660                 1665             


Leu Leu  Leu Glu Asn Leu Lys  Leu Ile Ser Asn Ala  Thr Ser Leu 
    1670                 1675                 1680             


Gln Gly  Glu Pro Ile Val Ile  Ser Val Ser Gln Ser  Thr Val Tyr 
    1685                 1690                 1695             


Ile Asn  Asn Lys Ala Lys Ile  Ile Ser Ser Asp Ile  Ile Ser Thr 
    1700                 1705                 1710             


Asn Gly  Ile Val His Ile Ile  Asp Lys Leu Leu Ser  Pro Lys Asn 
    1715                 1720                 1725             


Leu Leu  Ile Thr Pro Lys Asp  Asn Ser Gly Arg Ile  Leu Gln Asn 
    1730                 1735                 1740             


Leu Thr  Thr Leu Ala Thr Asn  Asn Gly Tyr Ile Lys  Phe Ser Asn 
    1745                 1750                 1755             


Leu Ile  Gln Asp Ser Gly Leu  Leu Ser Val Ile Thr  Asp Pro Ile 
    1760                 1765                 1770             


His Thr  Pro Val Thr Leu Phe  Trp Pro Thr Asp Gln  Ala Leu His 
    1775                 1780                 1785             


Ala Leu  Pro Ala Glu Gln Gln  Asp Phe Leu Phe Asn  Gln Asp Asn 
    1790                 1795                 1800             


Lys Asp  Lys Leu Lys Glu Tyr  Leu Lys Phe His Val  Ile Arg Asp 
    1805                 1810                 1815             


Ala Lys  Val Leu Ala Val Asp  Leu Pro Thr Ser Thr  Ala Trp Lys 
    1820                 1825                 1830             


Thr Leu  Gln Gly Ser Glu Leu  Ser Val Lys Cys Gly  Ala Gly Arg 
    1835                 1840                 1845             


Asp Ile  Gly Asp Leu Phe Leu  Asn Gly Gln Thr Cys  Arg Ile Val 
    1850                 1855                 1860             


Gln Arg  Glu Leu Leu Phe Asp  Leu Gly Val Ala Tyr  Gly Ile Asp 
    1865                 1870                 1875             


Cys Leu  Leu Ile Asp Pro Thr  Leu Gly Gly Arg Cys  Asp Thr Phe 
    1880                 1885                 1890             


Thr Thr  Phe Asp Ala Ser Gly  Glu Cys Gly Ser Cys  Val Asn Thr 
    1895                 1900                 1905             


Pro Ser  Cys Pro Arg Trp Ser  Lys Pro Lys Gly Val  Lys Gln Lys 
    1910                 1915                 1920             


Cys Leu  Tyr Asn Leu Pro Phe  Lys Arg Asn Leu Glu  Gly Cys Arg 
    1925                 1930                 1935             


Glu Arg  Cys Ser Leu Val Ile  Gln Ile Pro Arg Cys  Cys Lys Gly 
    1940                 1945                 1950             


Tyr Phe  Gly Arg Asp Cys Gln  Ala Cys Pro Gly Gly  Pro Asp Ala 
    1955                 1960                 1965             


Pro Cys  Asn Asn Arg Gly Val  Cys Leu Asp Gln Tyr  Ser Ala Thr 
    1970                 1975                 1980             


Gly Glu  Cys Lys Cys Asn Thr  Gly Phe Asn Gly Thr  Ala Cys Glu 
    1985                 1990                 1995             


Met Cys  Trp Pro Gly Arg Phe  Gly Pro Asp Cys Leu  Pro Cys Gly 
    2000                 2005                 2010             


Cys Ser  Asp His Gly Gln Cys  Asp Asp Gly Ile Thr  Gly Ser Gly 
    2015                 2020                 2025             


Gln Cys  Leu Cys Glu Thr Gly  Trp Thr Gly Pro Ser  Cys Asp Thr 
    2030                 2035                 2040             


Gln Ala  Val Leu Pro Ala Val  Cys Thr Pro Pro Cys  Ser Ala His 
    2045                 2050                 2055             


Ala Thr  Cys Lys Glu Asn Asn  Thr Cys Glu Cys Asn  Leu Asp Tyr 
    2060                 2065                 2070             


Glu Gly  Asp Gly Ile Thr Cys  Thr Val Val Asp Phe  Cys Lys Gln 
    2075                 2080                 2085             


Asp Asn  Gly Gly Cys Ala Lys  Val Ala Arg Cys Ser  Gln Lys Gly 
    2090                 2095                 2100             


Thr Lys  Val Ser Cys Ser Cys  Gln Lys Gly Tyr Lys  Gly Asp Gly 
    2105                 2110                 2115             


His Ser  Cys Thr Glu Ile Asp  Pro Cys Ala Asp Gly  Leu Asn Gly 
    2120                 2125                 2130             


Gly Cys  His Glu His Ala Thr  Cys Lys Met Thr Gly  Pro Gly Lys 
    2135                 2140                 2145             


His Lys  Cys Glu Cys Lys Ser  His Tyr Val Gly Asp  Gly Leu Asn 
    2150                 2155                 2160             


Cys Glu  Pro Glu Gln Leu Pro  Ile Asp Arg Cys Leu  Gln Asp Asn 
    2165                 2170                 2175             


Gly Gln  Cys His Ala Asp Ala  Lys Cys Val Asp Leu  His Phe Gln 
    2180                 2185                 2190             


Asp Thr  Thr Val Gly Val Phe  His Leu Arg Ser Pro  Leu Gly Gln 
    2195                 2200                 2205             


Tyr Lys  Leu Thr Phe Asp Lys  Ala Arg Glu Ala Cys  Ala Asn Glu 
    2210                 2215                 2220             


Ala Ala  Thr Met Ala Thr Tyr  Asn Gln Leu Ser Tyr  Ala Gln Lys 
    2225                 2230                 2235             


Ala Lys  Tyr His Leu Cys Ser  Ala Gly Trp Leu Glu  Thr Gly Arg 
    2240                 2245                 2250             


Val Ala  Tyr Pro Thr Ala Phe  Ala Ser Gln Asn Cys  Gly Ser Gly 
    2255                 2260                 2265             


Val Val  Gly Ile Val Asp Tyr  Gly Pro Arg Pro Asn  Lys Ser Glu 
    2270                 2275                 2280             


Met Trp  Asp Val Phe Cys Tyr  Arg Met Lys Asp Val  Asn Cys Thr 
    2285                 2290                 2295             


Cys Lys  Val Gly Tyr Val Gly  Asp Gly Phe Ser Cys  Ser Gly Asn 
    2300                 2305                 2310             


Leu Leu  Gln Val Leu Met Ser  Phe Pro Ser Leu Thr  Asn Phe Leu 
    2315                 2320                 2325             


Thr Glu  Val Leu Ala Tyr Ser  Asn Ser Ser Ala Arg  Gly Arg Ala 
    2330                 2335                 2340             


Phe Leu  Glu His Leu Thr Asp  Leu Ser Ile Arg Gly  Thr Leu Phe 
    2345                 2350                 2355             


Val Pro  Gln Asn Ser Gly Leu  Gly Glu Asn Glu Thr  Leu Ser Gly 
    2360                 2365                 2370             


Arg Asp  Ile Glu His His Leu  Ala Asn Val Ser Met  Phe Phe Tyr 
    2375                 2380                 2385             


Asn Asp  Leu Val Asn Gly Thr  Thr Leu Gln Thr Arg  Leu Gly Ser 
    2390                 2395                 2400             


Lys Leu  Leu Ile Thr Ala Ser  Gln Asp Pro Leu Gln  Pro Thr Glu 
    2405                 2410                 2415             


Thr Arg  Phe Val Asp Gly Arg  Ala Ile Leu Gln Trp  Asp Ile Phe 
    2420                 2425                 2430             


Ala Ser  Asn Gly Ile Ile His  Val Ile Ser Arg Pro  Leu Lys Ala 
    2435                 2440                 2445             


Pro Pro  Ala Pro Val Thr Leu  Thr His Thr Gly Leu  Gly Ala Gly 
    2450                 2455                 2460             


Ile Phe  Phe Ala Ile Ile Leu  Val Thr Gly Ala Val  Ala Leu Ala 
    2465                 2470                 2475             


Ala Tyr  Ser Tyr Phe Arg Ile  Asn Arg Arg Thr Ile  Gly Phe Gln 
    2480                 2485                 2490             


His Phe  Glu Ser Glu Glu Asp  Ile Asn Val Ala Ala  Leu Gly Lys 
    2495                 2500                 2505             


Gln Gln  Pro Glu Asn Ile Ser  Asn Pro Leu Tyr Glu  Ser Thr Thr 
    2510                 2515                 2520             


Ser Ala  Pro Pro Glu Pro Ser  Tyr Asp Pro Phe Thr  Asp Ser Glu 
    2525                 2530                 2535             


Glu Arg  Gln Leu Glu Gly Asn  Asp Pro Leu Arg Thr  Leu 
    2540                 2545                 2550     


<210>  510
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  510

Met Val Leu Ser Val Pro Val Ile Ala Leu Gly Ala Thr Leu Gly Thr 
1               5                   10                  15      


Ala Thr Ser Ile Leu Ala Leu Cys Gly Val Thr Cys Leu Cys Arg His 
            20                  25                  30          


Met His Pro Lys Lys Gly Leu Leu Pro Arg Asp Gln Asp Pro Asp Leu 
        35                  40                  45              


Glu Lys Ala Lys Pro Ser Leu Leu Gly Ser Ala Gln Gln Phe Asn Val 
    50                  55                  60                  


Lys Lys Ser Thr Glu Pro Val Gln Pro Arg Ala Leu Leu Lys Phe Pro 
65                  70                  75                  80  


Asp Ile Tyr Gly Pro Arg Pro Ala Val Thr Ala Pro Glu Val Ile Asn 
                85                  90                  95      


Tyr Ala Asp Tyr Ser Leu Arg Ser Thr Glu Glu Pro Thr Ala Pro Ala 
            100                 105                 110         


Ser Pro Gln Pro Pro Asn Asp Ser Arg Leu Lys Arg Gln Val Thr Glu 
        115                 120                 125             


Glu Leu Phe Ile Leu Pro Gln Asn Gly Val Val Glu Asp Val Cys Val 
    130                 135                 140                 


Met Glu Thr Trp Asn Pro Glu Lys Ala Ala Ser Trp Asn Gln Ala Pro 
145                 150                 155                 160 


Lys Leu His Tyr Cys Leu Asp Tyr Asp Cys Gln Lys Ala Glu Leu Phe 
                165                 170                 175     


Val Thr Arg Leu Glu Ala Val Thr Ser Asn His Asp Gly Gly Cys Asp 
            180                 185                 190         


Cys Tyr Val Gln Gly Ser Val Ala Asn Arg Thr Gly Ser Val Glu Ala 
        195                 200                 205             


Gln Thr Ala Leu Lys Lys Arg Gln Leu His Thr Thr Trp Glu Glu Gly 
    210                 215                 220                 


Leu Val Leu Pro Leu Ala Glu Glu Glu Leu Pro Thr Ala Thr Leu Thr 
225                 230                 235                 240 


Leu Thr Leu Arg Thr Cys Asp Arg Phe Ser Arg His Ser Val Ala Gly 
                245                 250                 255     


Glu Leu Arg Leu Gly Leu Asp Gly Thr Ser Val Pro Leu Gly Ala Ala 
            260                 265                 270         


Gln Trp Gly Glu Leu Lys Thr Ser Ala Lys Glu Pro Ser Ala Gly Ala 
        275                 280                 285             


Gly Glu Val Leu Leu Ser Ile Ser Tyr Leu Pro Ala Ala Asn Arg Leu 
    290                 295                 300                 


Leu Val Val Leu Ile Lys Ala Lys Asn Leu His Ser Asn Gln Ser Lys 
305                 310                 315                 320 


Glu Leu Leu Gly Lys Asp Val Ser Val Lys Val Thr Leu Lys His Gln 
                325                 330                 335     


Ala Arg Lys Leu Lys Lys Lys Gln Thr Lys Arg Ala Lys His Lys Ile 
            340                 345                 350         


Asn Pro Val Trp Asn Glu Met Ile Met Phe Glu Leu Pro Asp Asp Leu 
        355                 360                 365             


Leu Gln Ala Ser Ser Val Glu Leu Glu Val Leu Gly Gln Asp Asp Ser 
    370                 375                 380                 


Gly Gln Ser Cys Ala Leu Gly His Cys Ser Leu Gly Leu His Thr Ser 
385                 390                 395                 400 


Gly Ser Glu Arg Ser His Trp Glu Glu Met Leu Lys Asn Pro Arg Arg 
                405                 410                 415     


Gln Ile Ala Met Trp His Gln Leu His Leu 
            420                 425     


<210>  511
<211>  850
<212>  PRT
<213>  Homo sapiens

<400>  511

Met Thr Ser His Tyr Val Ile Ala Ile Phe Ala Leu Met Ser Ser Cys 
1               5                   10                  15      


Leu Ala Thr Ala Gly Pro Glu Pro Gly Ala Leu Cys Glu Leu Ser Pro 
            20                  25                  30          


Val Ser Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe Thr Val 
        35                  40                  45              


Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Gln Glu Val 
    50                  55                  60                  


His Val Leu Asn Leu Arg Thr Ala Gly Gln Gly Pro Gly Gln Leu Gln 
65                  70                  75                  80  


Arg Glu Val Thr Leu His Leu Asn Pro Ile Ser Ser Val His Ile His 
                85                  90                  95      


His Lys Ser Val Val Phe Leu Leu Asn Ser Pro His Pro Leu Val Trp 
            100                 105                 110         


His Leu Lys Thr Glu Arg Leu Ala Thr Gly Val Ser Arg Leu Phe Leu 
        115                 120                 125             


Val Ser Glu Gly Ser Val Val Gln Phe Ser Ser Ala Asn Phe Ser Leu 
    130                 135                 140                 


Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro His Gly Asn Glu His Leu 
145                 150                 155                 160 


Leu Asn Trp Ala Arg Lys Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu 
                165                 170                 175     


Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp Gln Val 
            180                 185                 190         


Phe Pro Pro Lys Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr 
        195                 200                 205             


Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val Met Ser 
    210                 215                 220                 


Ser Gln Pro Gln Asn Glu Glu Val His Ile Ile Glu Leu Ile Thr Pro 
225                 230                 235                 240 


Asn Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Thr Ile Asp Ile 
                245                 250                 255     


Arg Pro Ser Gln Glu Asp Leu Glu Val Val Lys Asn Leu Ile Leu Ile 
            260                 265                 270         


Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe Asp Val 
        275                 280                 285             


Lys Gly Ser Leu Lys Ile Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys 
    290                 295                 300                 


Glu Ser Glu Arg Ser Met Thr Met Thr Lys Ser Ile Arg Asp Asp Ile 
305                 310                 315                 320 


Pro Ser Thr Gln Gly Asn Leu Val Lys Trp Ala Leu Asp Asn Gly Tyr 
                325                 330                 335     


Ser Pro Ile Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg Phe His 
            340                 345                 350         


Leu Arg Leu Glu Asn Asn Glu Glu Met Gly Asp Glu Glu Val His Thr 
        355                 360                 365             


Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Gly Ala Leu Pro Ala 
    370                 375                 380                 


Leu Gln Asn Pro Pro Ile Arg Gly Gly Glu Gly Gln Asn Gly Gly Leu 
385                 390                 395                 400 


Pro Phe Pro Phe Pro Asp Ile Ser Arg Arg Val Trp Asn Glu Glu Gly 
                405                 410                 415     


Glu Asp Gly Leu Pro Arg Pro Lys Asp Pro Val Ile Pro Ser Ile Gln 
            420                 425                 430         


Leu Phe Pro Gly Leu Arg Glu Pro Glu Glu Val Gln Gly Ser Val Asp 
        435                 440                 445             


Ile Ala Leu Ser Val Lys Cys Asp Asn Glu Lys Met Ile Val Ala Val 
    450                 455                 460                 


Glu Lys Asp Ser Phe Gln Ala Ser Gly Tyr Ser Gly Met Asp Val Thr 
465                 470                 475                 480 


Leu Leu Asp Pro Thr Cys Lys Ala Lys Met Asn Gly Thr His Phe Val 
                485                 490                 495     


Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg Pro Arg Trp Ser Ala 
            500                 505                 510         


Leu Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Ile Gln Val Pro Ala 
        515                 520                 525             


Leu Gly Asp Ser Ser Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu Ser 
    530                 535                 540                 


Gly Asp Asn Gly Phe Pro Gly Asp Met Asp Glu Gly Asp Ala Ser Leu 
545                 550                 555                 560 


Phe Thr Arg Pro Glu Ile Val Val Phe Asn Cys Ser Leu Gln Gln Val 
                565                 570                 575     


Arg Asn Pro Ser Ser Phe Gln Glu Gln Pro His Gly Asn Ile Thr Phe 
            580                 585                 590         


Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Gln Gly 
        595                 600                 605             


Val Phe Ser Val Pro Glu Asn Gly His Val Tyr Val Glu Val Ser Val 
    610                 615                 620                 


Thr Lys Ala Glu Gln Glu Leu Gly Phe Ala Ile Gln Thr Cys Phe Ile 
625                 630                 635                 640 


Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser His Tyr Thr Ile Ile Glu 
                645                 650                 655     


Asn Ile Cys Pro Lys Asp Glu Ser Val Lys Phe Tyr Ser Pro Lys Arg 
            660                 665                 670         


Val His Phe Pro Ile Pro Gln Ala Asp Met Asp Lys Lys Arg Phe Ser 
        675                 680                 685             


Phe Val Phe Lys Pro Val Phe Asn Thr Ser Leu Leu Phe Leu Gln Cys 
    690                 695                 700                 


Glu Leu Thr Leu Cys Thr Lys Met Glu Lys His Pro Gln Lys Leu Pro 
705                 710                 715                 720 


Lys Cys Val Pro Pro Asp Glu Ala Cys Thr Ser Leu Asp Ala Ser Ile 
                725                 730                 735     


Ile Trp Ala Met Met Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu Ala 
            740                 745                 750         


Val Ile His His Glu Ala Glu Ser Lys Glu Lys Gly Pro Ser Met Lys 
        755                 760                 765             


Glu Pro Asn Pro Ile Ser Pro Pro Ile Phe His Gly Leu Asp Thr Leu 
    770                 775                 780                 


Thr Val Met Gly Ile Ala Phe Ala Ala Phe Val Ile Gly Ala Leu Leu 
785                 790                 795                 800 


Thr Gly Ala Leu Trp Tyr Ile Tyr Ser His Thr Gly Glu Thr Ala Gly 
                805                 810                 815     


Arg Gln Gln Val Pro Thr Ser Pro Pro Ala Ser Glu Asn Ser Ser Ala 
            820                 825                 830         


Ala His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Ser Ser Ser 
        835                 840                 845             


Thr Ala 
    850 


<210>  512
<211>  850
<212>  PRT
<213>  Homo sapiens

<400>  512

Met Thr Ser His Tyr Val Ile Ala Ile Phe Ala Leu Met Ser Ser Cys 
1               5                   10                  15      


Leu Ala Thr Ala Gly Pro Glu Pro Gly Ala Leu Cys Glu Leu Ser Pro 
            20                  25                  30          


Val Ser Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe Thr Val 
        35                  40                  45              


Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Gln Glu Val 
    50                  55                  60                  


His Val Leu Asn Leu Arg Thr Ala Gly Gln Gly Pro Gly Gln Leu Gln 
65                  70                  75                  80  


Arg Glu Val Thr Leu His Leu Asn Pro Ile Ser Ser Val His Ile His 
                85                  90                  95      


His Lys Ser Val Val Phe Leu Leu Asn Ser Pro His Pro Leu Val Trp 
            100                 105                 110         


His Leu Lys Thr Glu Arg Leu Ala Thr Gly Val Ser Arg Leu Phe Leu 
        115                 120                 125             


Val Ser Glu Gly Ser Val Val Gln Phe Ser Ser Ala Asn Phe Ser Leu 
    130                 135                 140                 


Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro His Gly Asn Glu His Leu 
145                 150                 155                 160 


Leu Asn Trp Ala Arg Lys Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu 
                165                 170                 175     


Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp Gln Val 
            180                 185                 190         


Phe Pro Pro Lys Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr 
        195                 200                 205             


Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val Met Ser 
    210                 215                 220                 


Ser Gln Pro Gln Asn Glu Glu Val His Ile Ile Glu Leu Ile Thr Pro 
225                 230                 235                 240 


Asn Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Thr Ile Asp Ile 
                245                 250                 255     


Arg Pro Ser Gln Glu Asp Leu Glu Val Val Lys Asn Leu Ile Leu Ile 
            260                 265                 270         


Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe Asp Val 
        275                 280                 285             


Lys Gly Ser Leu Lys Ile Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys 
    290                 295                 300                 


Glu Ser Glu Arg Ser Met Thr Met Thr Lys Ser Ile Arg Asp Asp Ile 
305                 310                 315                 320 


Pro Ser Thr Gln Gly Asn Leu Val Lys Trp Ala Leu Asp Asn Gly Tyr 
                325                 330                 335     


Ser Pro Ile Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg Phe His 
            340                 345                 350         


Leu Arg Leu Glu Asn Asn Glu Glu Met Gly Asp Glu Glu Val His Thr 
        355                 360                 365             


Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Gly Ala Leu Pro Ala 
    370                 375                 380                 


Leu Gln Asn Pro Pro Ile Arg Gly Gly Glu Gly Gln Asn Gly Gly Leu 
385                 390                 395                 400 


Pro Phe Pro Phe Pro Asp Ile Ser Arg Arg Val Trp Asn Glu Glu Gly 
                405                 410                 415     


Glu Asp Gly Leu Pro Arg Pro Lys Asp Pro Val Ile Pro Ser Ile Gln 
            420                 425                 430         


Leu Phe Pro Gly Leu Arg Glu Pro Glu Glu Val Gln Gly Ser Val Asp 
        435                 440                 445             


Ile Ala Leu Ser Val Lys Cys Asp Asn Glu Lys Met Ile Val Ala Val 
    450                 455                 460                 


Glu Lys Asp Ser Phe Gln Ala Ser Gly Tyr Ser Gly Met Asp Val Thr 
465                 470                 475                 480 


Leu Leu Asp Pro Thr Cys Lys Ala Lys Met Asn Gly Thr His Phe Val 
                485                 490                 495     


Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg Pro Arg Trp Ser Ala 
            500                 505                 510         


Leu Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Ile Gln Val Pro Ala 
        515                 520                 525             


Leu Gly Asp Ser Ser Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu Ser 
    530                 535                 540                 


Gly Asp Asn Gly Phe Pro Gly Asp Met Asp Glu Gly Asp Ala Ser Leu 
545                 550                 555                 560 


Phe Thr Arg Pro Glu Ile Val Val Phe Asn Cys Ser Leu Gln Gln Val 
                565                 570                 575     


Arg Asn Pro Ser Ser Phe Gln Glu Gln Pro His Gly Asn Ile Thr Phe 
            580                 585                 590         


Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Gln Gly 
        595                 600                 605             


Val Phe Ser Val Pro Glu Asn Gly His Val Tyr Val Glu Val Ser Val 
    610                 615                 620                 


Thr Lys Ala Glu Gln Glu Leu Gly Phe Ala Ile Gln Thr Cys Phe Ile 
625                 630                 635                 640 


Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser His Tyr Thr Ile Ile Glu 
                645                 650                 655     


Asn Ile Cys Pro Lys Asp Glu Ser Val Lys Phe Tyr Ser Pro Lys Arg 
            660                 665                 670         


Val His Phe Pro Ile Pro Gln Ala Asp Met Asp Lys Lys Arg Phe Ser 
        675                 680                 685             


Phe Val Phe Lys Pro Val Phe Asn Thr Ser Leu Leu Phe Leu Gln Cys 
    690                 695                 700                 


Glu Leu Thr Leu Cys Thr Lys Met Glu Lys His Pro Gln Lys Leu Pro 
705                 710                 715                 720 


Lys Cys Val Pro Pro Asp Glu Ala Cys Thr Ser Leu Asp Ala Ser Ile 
                725                 730                 735     


Ile Trp Ala Met Met Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu Ala 
            740                 745                 750         


Val Ile His His Glu Ala Glu Ser Lys Glu Lys Gly Pro Ser Met Lys 
        755                 760                 765             


Glu Pro Asn Pro Ile Ser Pro Pro Ile Phe His Gly Leu Asp Thr Leu 
    770                 775                 780                 


Thr Val Met Gly Ile Ala Phe Ala Ala Phe Val Ile Gly Ala Leu Leu 
785                 790                 795                 800 


Thr Gly Ala Leu Trp Tyr Ile Tyr Ser His Thr Gly Glu Thr Ala Gly 
                805                 810                 815     


Arg Gln Gln Val Pro Thr Ser Pro Pro Ala Ser Glu Asn Ser Ser Ala 
            820                 825                 830         


Ala His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Ser Ser Ser 
        835                 840                 845             


Thr Ala 
    850 


<210>  513
<211>  851
<212>  PRT
<213>  Homo sapiens

<400>  513

Met Thr Ser His Tyr Val Ile Ala Ile Phe Ala Leu Met Ser Ser Cys 
1               5                   10                  15      


Leu Ala Thr Ala Gly Pro Glu Pro Gly Ala Leu Cys Glu Leu Ser Pro 
            20                  25                  30          


Val Ser Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe Thr Val 
        35                  40                  45              


Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Gln Glu Val 
    50                  55                  60                  


His Val Leu Asn Leu Arg Thr Ala Gly Gln Gly Pro Gly Gln Leu Gln 
65                  70                  75                  80  


Arg Glu Val Thr Leu His Leu Asn Pro Ile Ser Ser Val His Ile His 
                85                  90                  95      


His Lys Ser Val Val Phe Leu Leu Asn Ser Pro His Pro Leu Val Trp 
            100                 105                 110         


His Leu Lys Thr Glu Arg Leu Ala Thr Gly Val Ser Arg Leu Phe Leu 
        115                 120                 125             


Val Ser Glu Gly Ser Val Val Gln Phe Ser Ser Ala Asn Phe Ser Leu 
    130                 135                 140                 


Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro His Gly Asn Glu His Leu 
145                 150                 155                 160 


Leu Asn Trp Ala Arg Lys Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu 
                165                 170                 175     


Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp Gln Val 
            180                 185                 190         


Phe Pro Pro Lys Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr 
        195                 200                 205             


Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val Met Ser 
    210                 215                 220                 


Ser Gln Pro Gln Asn Glu Glu Val His Ile Ile Glu Leu Ile Thr Pro 
225                 230                 235                 240 


Asn Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Thr Ile Asp Ile 
                245                 250                 255     


Arg Pro Ser Gln Glu Asp Leu Glu Val Val Lys Asn Leu Ile Leu Ile 
            260                 265                 270         


Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe Asp Val 
        275                 280                 285             


Lys Gly Ser Leu Lys Ile Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys 
    290                 295                 300                 


Glu Ser Glu Arg Ser Met Thr Met Thr Lys Ser Ile Arg Asp Asp Ile 
305                 310                 315                 320 


Pro Ser Thr Gln Gly Asn Leu Val Lys Trp Ala Leu Asp Asn Gly Tyr 
                325                 330                 335     


Ser Pro Ile Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg Phe His 
            340                 345                 350         


Leu Arg Leu Glu Asn Asn Ala Glu Glu Met Gly Asp Glu Glu Val His 
        355                 360                 365             


Thr Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Gly Ala Leu Pro 
    370                 375                 380                 


Ala Leu Gln Asn Pro Pro Ile Arg Gly Gly Glu Gly Gln Asn Gly Gly 
385                 390                 395                 400 


Leu Pro Phe Pro Phe Pro Asp Ile Ser Arg Arg Val Trp Asn Glu Glu 
                405                 410                 415     


Gly Glu Asp Gly Leu Pro Arg Pro Lys Asp Pro Val Ile Pro Ser Ile 
            420                 425                 430         


Gln Leu Phe Pro Gly Leu Arg Glu Pro Glu Glu Val Gln Gly Ser Val 
        435                 440                 445             


Asp Ile Ala Leu Ser Val Lys Cys Asp Asn Glu Lys Met Ile Val Ala 
    450                 455                 460                 


Val Glu Lys Asp Ser Phe Gln Ala Ser Gly Tyr Ser Gly Met Asp Val 
465                 470                 475                 480 


Thr Leu Leu Asp Pro Thr Cys Lys Ala Lys Met Asn Gly Thr His Phe 
                485                 490                 495     


Val Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg Pro Arg Trp Ser 
            500                 505                 510         


Ala Leu Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Ile Gln Val Pro 
        515                 520                 525             


Ala Leu Gly Asp Ser Ser Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu 
    530                 535                 540                 


Ser Gly Asp Asn Gly Phe Pro Gly Asp Met Asp Glu Gly Asp Ala Ser 
545                 550                 555                 560 


Leu Phe Thr Arg Pro Glu Ile Val Val Phe Asn Cys Ser Leu Gln Gln 
                565                 570                 575     


Val Arg Asn Pro Ser Ser Phe Gln Glu Gln Pro His Gly Asn Ile Thr 
            580                 585                 590         


Phe Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Gln 
        595                 600                 605             


Gly Val Phe Ser Val Pro Glu Asn Gly His Val Tyr Val Glu Val Ser 
    610                 615                 620                 


Val Thr Lys Ala Glu Gln Glu Leu Gly Phe Ala Ile Gln Thr Cys Phe 
625                 630                 635                 640 


Ile Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser His Tyr Thr Ile Ile 
                645                 650                 655     


Glu Asn Ile Cys Pro Lys Asp Glu Ser Val Lys Phe Tyr Ser Pro Lys 
            660                 665                 670         


Arg Val His Phe Pro Ile Pro Gln Ala Asp Met Asp Lys Lys Arg Phe 
        675                 680                 685             


Ser Phe Val Phe Lys Pro Val Phe Asn Thr Ser Leu Leu Phe Leu Gln 
    690                 695                 700                 


Cys Glu Leu Thr Leu Cys Thr Lys Met Glu Lys His Pro Gln Lys Leu 
705                 710                 715                 720 


Pro Lys Cys Val Pro Pro Asp Glu Ala Cys Thr Ser Leu Asp Ala Ser 
                725                 730                 735     


Ile Ile Trp Ala Met Met Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu 
            740                 745                 750         


Ala Val Ile His His Glu Ala Glu Ser Lys Glu Lys Gly Pro Ser Met 
        755                 760                 765             


Lys Glu Pro Asn Pro Ile Ser Pro Pro Ile Phe His Gly Leu Asp Thr 
    770                 775                 780                 


Leu Thr Val Met Gly Ile Ala Phe Ala Ala Phe Val Ile Gly Ala Leu 
785                 790                 795                 800 


Leu Thr Gly Ala Leu Trp Tyr Ile Tyr Ser His Thr Gly Glu Thr Ala 
                805                 810                 815     


Gly Arg Gln Gln Val Pro Thr Ser Pro Pro Ala Ser Glu Asn Ser Ser 
            820                 825                 830         


Ala Ala His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Ser Ser 
        835                 840                 845             


Ser Thr Ala 
    850     


<210>  514
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  514

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Leu Gln Val 
1               5                   10                  15      


Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln 
            20                  25                  30          


Ser Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile 
        35                  40                  45              


Gln Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe 
    50                  55                  60                  


Gly Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe 
65                  70                  75                  80  


Thr Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser 
                85                  90                  95      


Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser 
            100                 105                 110         


Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val 
        115                 120                 125             


Lys Cys Glu Gly Ile Ser Leu Leu Ala Gln Asn Thr Ser Trp Leu Leu 
    130                 135                 140                 


Leu Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Thr Asp Phe Met Ser 
145                 150                 155                 160 


Leu 
    


<210>  515
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  515

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Leu Gln Val 
1               5                   10                  15      


Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln 
            20                  25                  30          


Ser Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile 
        35                  40                  45              


Gln Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe 
    50                  55                  60                  


Gly Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe 
65                  70                  75                  80  


Thr Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser 
                85                  90                  95      


Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser 
            100                 105                 110         


Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val 
        115                 120                 125             


Lys Cys Glu Gly Ile Ser Leu Leu Ala Gln Asn Thr Ser Trp Leu Leu 
    130                 135                 140                 


Leu Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Thr Asp Phe Met Ser 
145                 150                 155                 160 


Leu 
    


<210>  516
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  516

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Leu Gln Val 
1               5                   10                  15      


Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln 
            20                  25                  30          


Ser Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile 
        35                  40                  45              


Gln Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe 
    50                  55                  60                  


Gly Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe 
65                  70                  75                  80  


Thr Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser 
                85                  90                  95      


Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser 
            100                 105                 110         


Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val 
        115                 120                 125             


Lys Cys Glu Gly Ile Ser Leu Leu Ala Gln Asn Thr Ser Trp Leu Leu 
    130                 135                 140                 


Leu Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Thr Asp Phe Met Ser 
145                 150                 155                 160 


Leu 
    


<210>  517
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  517

Met Thr Glu Glu Pro Ile Lys Glu Ile Leu Gly Ala Pro Lys Ala His 
1               5                   10                  15      


Met Ala Ala Thr Met Glu Lys Ser Pro Lys Ser Glu Val Val Ile Thr 
            20                  25                  30          


Thr Val Pro Leu Val Ser Glu Ile Gln Leu Met Ala Ala Thr Gly Gly 
        35                  40                  45              


Thr Glu Leu Ser Cys Tyr Arg Cys Ile Ile Pro Phe Ala Val Val Val 
    50                  55                  60                  


Phe Ile Ala Gly Ile Val Val Thr Ala Val Ala Tyr Ser Phe Asn Ser 
65                  70                  75                  80  


His Gly Ser Ile Ile Ser Ile Phe Gly Leu Val Val Leu Ser Ser Gly 
                85                  90                  95      


Leu Phe Leu Leu Ala Ser Ser Ala Leu Cys Trp Lys Val Arg Gln Arg 
            100                 105                 110         


Ser Lys Lys Ala Lys Arg Arg Glu Ser Gln Thr Ala Leu Val Ala Asn 
        115                 120                 125             


Gln Arg Ser Leu Phe Ala 
    130                 


<210>  518
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  518

Met Thr Glu Glu Pro Ile Lys Glu Ile Leu Gly Ala Pro Lys Ala His 
1               5                   10                  15      


Met Ala Ala Thr Met Glu Lys Ser Pro Lys Ser Glu Val Val Ile Thr 
            20                  25                  30          


Thr Val Pro Leu Val Ser Glu Ile Gln Leu Met Ala Ala Thr Gly Gly 
        35                  40                  45              


Thr Glu Leu Ser Cys Tyr Arg Cys Ile Ile Pro Phe Ala Val Val Val 
    50                  55                  60                  


Phe Ile Ala Gly Ile Val Val Thr Ala Val Ala Tyr Ser Phe Asn Ser 
65                  70                  75                  80  


His Gly Ser Ile Ile Ser Ile Phe Gly Leu Val Val Leu Ser Ser Gly 
                85                  90                  95      


Leu Phe Leu Leu Ala Ser Ser Ala Leu Cys Trp Lys Val Arg Gln Arg 
            100                 105                 110         


Ser Lys Lys Ala Lys Arg Arg Glu Ser Gln Thr Ala Leu Val Ala Asn 
        115                 120                 125             


Gln Arg Ser Leu Phe Ala 
    130                 


<210>  519
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  519

Met Trp Gly Tyr Leu Ser Leu Met Pro Val Phe Leu Ala Val Trp Ala 
1               5                   10                  15      


Ile Ser Gly Val Trp Ile Val Phe Ala Ile Ala Val Thr Asn Arg Thr 
            20                  25                  30          


Val Asp Leu Ser Lys Gly Phe Pro Tyr Ile Ser Ile Cys Gly Ser Phe 
        35                  40                  45              


Pro Pro Gln Ser Cys Ile Phe Ser Gln Val Leu Asn Met Gly Ala Ala 
    50                  55                  60                  


Leu Ala Ala Trp Ile Cys Ile Val Arg Tyr His Gln Leu Arg Asp Trp 
65                  70                  75                  80  


Gly Val Arg Arg Trp Pro Asn Gln Leu Ile Leu Trp Thr Gly Leu Leu 
                85                  90                  95      


Cys Ala Leu Gly Thr Ser Val Val Gly Asn Phe Gln Glu Lys Asn Gln 
            100                 105                 110         


Arg Pro Thr His Leu Ala Gly Ala Phe Leu Ala Phe Ile Leu Gly Asn 
        115                 120                 125             


Val Tyr Phe Trp Leu Gln Leu Leu Leu Trp Arg Leu Lys Arg Leu Pro 
    130                 135                 140                 


Gln Pro Gly Ala Ala Trp Ile Gly Pro Leu Arg Leu Gly Leu Cys Ser 
145                 150                 155                 160 


Val Cys Thr Ile Leu Ile Val Ala Met Ile Val Leu His Ala Cys Ser 
                165                 170                 175     


Leu Arg Ser Val Ser Ala Ala Cys Glu Trp Val Val Ala Met Leu Leu 
            180                 185                 190         


Phe Ala Leu Phe Gly Leu Leu Ala Val Asp Phe Ser Ala Leu Glu Ser 
        195                 200                 205             


Cys Thr Leu Cys Val Gln Pro Trp Pro Ser Leu Ser Pro Pro Pro Ala 
    210                 215                 220                 


Ser Pro Ile Ser Leu Pro Val Gln Leu 
225                 230             


<210>  520
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  520

Met Trp Gly Tyr Leu Ser Leu Met Pro Val Phe Leu Ala Val Trp Ala 
1               5                   10                  15      


Ile Ser Gly Val Trp Ile Val Phe Ala Ile Ala Val Thr Asn Arg Thr 
            20                  25                  30          


Val Asp Leu Ser Lys Gly Phe Pro Tyr Ile Ser Ile Cys Gly Ser Phe 
        35                  40                  45              


Pro Pro Gln Ser Cys Ile Phe Ser Gln Val Leu Asn Met Gly Ala Ala 
    50                  55                  60                  


Leu Ala Ala Trp Ile Cys Ile Val Arg Tyr His Gln Leu Arg Asp Trp 
65                  70                  75                  80  


Gly Val Arg Arg Trp Pro Asn Gln Leu Ile Leu Trp Thr Gly Leu Leu 
                85                  90                  95      


Cys Ala Leu Gly Thr Ser Val Val Gly Asn Phe Gln Glu Lys Asn Gln 
            100                 105                 110         


Arg Pro Thr His Leu Ala Gly Ala Phe Leu Ala Phe Ile Leu Gly Asn 
        115                 120                 125             


Val Tyr Phe Trp Leu Gln Leu Leu Leu Trp Arg Leu Lys Arg Leu Pro 
    130                 135                 140                 


Gln Pro Gly Ala Ala Trp Ile Gly Pro Leu Arg Leu Gly Leu Cys Ser 
145                 150                 155                 160 


Val Cys Thr Ile Leu Ile Val Ala Met Ile Val Leu His Ala Cys Ser 
                165                 170                 175     


Leu Arg Ser Val Ser Ala Ala Cys Glu Trp Val Val Ala Met Leu Leu 
            180                 185                 190         


Phe Ala Leu Phe Gly Leu Leu Ala Val Asp Phe Ser Ala Leu Glu Ser 
        195                 200                 205             


Cys Thr Leu Cys Val Gln Pro Trp Pro Ser Leu Ser Pro Pro Pro Ala 
    210                 215                 220                 


Ser Pro Ile Ser Leu Pro Val Gln Leu 
225                 230             


<210>  521
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  521

Met Glu Leu Pro Asp Pro Val Arg Gln Arg Leu Gly Asn Phe Ser Arg 
1               5                   10                  15      


Ala Val Phe Ser Asp Ser Asn Arg Thr Gly Pro Glu Ser Asn Glu Gly 
            20                  25                  30          


Pro Glu Asn Glu Met Val Ser Ser Leu Ala Leu Gln Met Ser Leu Tyr 
        35                  40                  45              


Phe Asn Thr Tyr Tyr Phe Pro Leu Trp Trp Val Ser Ser Ile Met Met 
    50                  55                  60                  


Leu His Met Lys Tyr Ser Ile Leu Pro Asp Tyr Tyr Lys Phe Ile Val 
65                  70                  75                  80  


Ile Thr Val Ile Ile Leu Ile Thr Leu Ile Glu Ala Ile Arg Leu Tyr 
                85                  90                  95      


Leu Gly Tyr Val Gly Asn Leu Gln Glu Lys Val Pro Glu Leu Ala Gly 
            100                 105                 110         


Phe Trp Leu Leu Ser Leu Leu Leu Gln Leu Pro Leu Ile Leu Phe Leu 
        115                 120                 125             


Leu Phe Asn Glu Gly Leu Thr Asn Leu Pro Leu Glu Lys Ala Ile His 
    130                 135                 140                 


Ile Ile Phe Thr Leu Phe Leu Ala Phe Gln Val Val Ala Ala Phe Leu 
145                 150                 155                 160 


Thr Leu Arg Lys Met Val Asn Gln Leu Ala Val Arg Phe His Leu Gln 
                165                 170                 175     


Asp Phe Asp Arg Leu Ser Ala Asn Arg Gly Asp Met Arg Arg Met Arg 
            180                 185                 190         


Ser Cys Ile Glu Glu Ile 
        195             


<210>  522
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  522

Met Leu Trp Leu Leu Phe Phe Leu Val Thr Ala Ile His Ala Glu Leu 
1               5                   10                  15      


Cys Gln Pro Gly Ala Glu Asn Ala Phe Lys Val Arg Leu Ser Ile Arg 
            20                  25                  30          


Thr Ala Leu Gly Asp Lys Ala Tyr Ala Trp Asp Thr Asn Glu Glu Tyr 
        35                  40                  45              


Leu Phe Lys Ala Met Val Ala Phe Ser Met Arg Lys Val Pro Asn Arg 
    50                  55                  60                  


Glu Ala Thr Glu Ile Ser His Val Leu Leu Cys Asn Val Thr Gln Arg 
65                  70                  75                  80  


Val Ser Phe Trp Phe Val Val Thr Asp Pro Ser Lys Asn His Thr Leu 
                85                  90                  95      


Pro Ala Val Glu Val Gln Ser Ala Ile Arg Met Asn Lys Asn Arg Ile 
            100                 105                 110         


Asn Asn Ala Phe Phe Leu Asn Asp Gln Thr Leu Glu Phe Leu Lys Ile 
        115                 120                 125             


Pro Ser Thr Leu Ala Pro Pro Met Asp Pro Ser Val Pro Ile Trp Ile 
    130                 135                 140                 


Ile Ile Phe Gly Val Ile Phe Cys Ile Ile Ile Val Ala Ile Ala Leu 
145                 150                 155                 160 


Leu Ile Leu Ser Gly Ile Trp Gln Arg Arg Arg Lys Asn Lys Glu Pro 
                165                 170                 175     


Ser Glu Val Asp Asp Ala Glu Asp Lys Cys Glu Asn Met Ile Thr Ile 
            180                 185                 190         


Glu Asn Gly Ile Pro Ser Asp Pro Leu Asp Met Lys Gly Gly His Ile 
        195                 200                 205             


Asn Asp Ala Phe Met Thr Glu Asp Glu Arg Leu Thr Pro Leu 
    210                 215                 220         


<210>  523
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  523

Met Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  524
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  524

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  525
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  525

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  526
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  526

Met Pro Gly Gly Cys Ser Arg Gly Pro Ala Ala Gly Asp Gly Arg Leu 
1               5                   10                  15      


Arg Leu Ala Arg Leu Ala Leu Val Leu Leu Gly Trp Val Ser Ser Ser 
            20                  25                  30          


Ser Pro Thr Ser Ser Ala Ser Ser Phe Ser Ser Ser Ala Pro Phe Leu 
        35                  40                  45              


Ala Ser Ala Val Ser Ala Gln Pro Pro Leu Pro Asp Gln Cys Pro Ala 
    50                  55                  60                  


Leu Cys Glu Cys Ser Glu Ala Ala Arg Thr Val Lys Cys Val Asn Arg 
65                  70                  75                  80  


Asn Leu Thr Glu Val Pro Thr Asp Leu Pro Ala Tyr Val Arg Asn Leu 
                85                  90                  95      


Phe Leu Thr Gly Asn Gln Leu Ala Val Leu Pro Ala Gly Ala Phe Ala 
            100                 105                 110         


Arg Arg Pro Pro Leu Ala Glu Leu Ala Ala Leu Asn Leu Ser Gly Ser 
        115                 120                 125             


Arg Leu Asp Glu Val Arg Ala Gly Ala Phe Glu His Leu Pro Ser Leu 
    130                 135                 140                 


Arg Gln Leu Asp Leu Ser His Asn Pro Leu Ala Asp Leu Ser Pro Phe 
145                 150                 155                 160 


Ala Phe Ser Gly Ser Asn Ala Ser Val Ser Ala Pro Ser Pro Leu Val 
                165                 170                 175     


Glu Leu Ile Leu Asn His Ile Val Pro Pro Glu Asp Glu Arg Gln Asn 
            180                 185                 190         


Arg Ser Phe Glu Gly Met Val Val Ala Ala Leu Leu Ala Gly Arg Ala 
        195                 200                 205             


Leu Gln Gly Leu Arg Arg Leu Glu Leu Ala Ser Asn His Phe Leu Tyr 
    210                 215                 220                 


Leu Pro Arg Asp Val Leu Ala Gln Leu Pro Ser Leu Arg His Leu Asp 
225                 230                 235                 240 


Leu Ser Asn Asn Ser Leu Val Ser Leu Thr Tyr Val Ser Phe Arg Asn 
                245                 250                 255     


Leu Thr His Leu Glu Ser Leu His Leu Glu Asp Asn Ala Leu Lys Val 
            260                 265                 270         


Leu His Asn Gly Thr Leu Ala Glu Leu Gln Gly Leu Pro His Ile Arg 
        275                 280                 285             


Val Phe Leu Asp Asn Asn Pro Trp Val Cys Asp Cys His Met Ala Asp 
    290                 295                 300                 


Met Val Thr Trp Leu Lys Glu Thr Glu Val Val Gln Gly Lys Asp Arg 
305                 310                 315                 320 


Leu Thr Cys Ala Tyr Pro Glu Lys Met Arg Asn Arg Val Leu Leu Glu 
                325                 330                 335     


Leu Asn Ser Ala Asp Leu Asp Cys Asp Pro Ile Leu Pro Pro Ser Leu 
            340                 345                 350         


Gln Thr Ser Tyr Val Phe Leu Gly Ile Val Leu Ala Leu Ile Gly Ala 
        355                 360                 365             


Ile Phe Leu Leu Val Leu Tyr Leu Asn Arg Lys Gly Ile Lys Lys Trp 
    370                 375                 380                 


Met His Asn Ile Arg Asp Ala Cys Arg Asp His Met Glu Gly Tyr His 
385                 390                 395                 400 


Tyr Arg Tyr Glu Ile Asn Ala Asp Pro Arg Leu Thr Asn Leu Ser Ser 
                405                 410                 415     


Asn Ser Asp Val 
            420 


<210>  527
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  527

Met Pro Gly Gly Cys Ser Arg Gly Pro Ala Ala Gly Asp Gly Arg Leu 
1               5                   10                  15      


Arg Leu Ala Arg Leu Ala Leu Val Leu Leu Gly Trp Val Ser Ser Ser 
            20                  25                  30          


Ser Pro Thr Ser Ser Ala Ser Ser Phe Ser Ser Ser Ala Pro Phe Leu 
        35                  40                  45              


Ala Ser Ala Val Ser Ala Gln Pro Pro Leu Pro Asp Gln Cys Pro Ala 
    50                  55                  60                  


Leu Cys Glu Cys Ser Glu Ala Ala Arg Thr Val Lys Cys Val Asn Arg 
65                  70                  75                  80  


Asn Leu Thr Glu Val Pro Thr Asp Leu Pro Ala Tyr Val Arg Asn Leu 
                85                  90                  95      


Phe Leu Thr Gly Asn Gln Leu Ala Val Leu Pro Ala Gly Ala Phe Ala 
            100                 105                 110         


Arg Arg Pro Pro Leu Ala Glu Leu Ala Ala Leu Asn Leu Ser Gly Ser 
        115                 120                 125             


Arg Leu Asp Glu Val Arg Ala Gly Ala Phe Glu His Leu Pro Ser Leu 
    130                 135                 140                 


Arg Gln Leu Asp Leu Ser His Asn Pro Leu Ala Asp Leu Ser Pro Phe 
145                 150                 155                 160 


Ala Phe Ser Gly Ser Asn Ala Ser Val Ser Ala Pro Ser Pro Leu Val 
                165                 170                 175     


Glu Leu Ile Leu Asn His Ile Val Pro Pro Glu Asp Glu Arg Gln Asn 
            180                 185                 190         


Arg Ser Phe Glu Gly Met Val Val Ala Ala Leu Leu Ala Gly Arg Ala 
        195                 200                 205             


Leu Gln Gly Leu Arg Arg Leu Glu Leu Ala Ser Asn His Phe Leu Tyr 
    210                 215                 220                 


Leu Pro Arg Asp Val Leu Ala Gln Leu Pro Ser Leu Arg His Leu Asp 
225                 230                 235                 240 


Leu Ser Asn Asn Ser Leu Val Ser Leu Thr Tyr Val Ser Phe Arg Asn 
                245                 250                 255     


Leu Thr His Leu Glu Ser Leu His Leu Glu Asp Asn Ala Leu Lys Val 
            260                 265                 270         


Leu His Asn Gly Thr Leu Ala Glu Leu Gln Gly Leu Pro His Ile Arg 
        275                 280                 285             


Val Phe Leu Asp Asn Asn Pro Trp Val Cys Asp Cys His Met Ala Asp 
    290                 295                 300                 


Met Val Thr Trp Leu Lys Glu Thr Glu Val Val Gln Gly Lys Asp Arg 
305                 310                 315                 320 


Leu Thr Cys Ala Tyr Pro Glu Lys Met Arg Asn Arg Val Leu Leu Glu 
                325                 330                 335     


Leu Asn Ser Ala Asp Leu Asp Cys Asp Pro Ile Leu Pro Pro Ser Leu 
            340                 345                 350         


Gln Thr Ser Tyr Val Phe Leu Gly Ile Val Leu Ala Leu Ile Gly Ala 
        355                 360                 365             


Ile Phe Leu Leu Val Leu Tyr Leu Asn Arg Lys Gly Ile Lys Lys Trp 
    370                 375                 380                 


Met His Asn Ile Arg Asp Ala Cys Arg Asp His Met Glu Gly Tyr His 
385                 390                 395                 400 


Tyr Arg Tyr Glu Ile Asn Ala Asp Pro Arg Leu Thr Asn Leu Ser Ser 
                405                 410                 415     


Asn Ser Asp Val 
            420 


<210>  528
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  528

Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ala Glu Arg His Val Lys Glu Asp Asp Gly Arg Lys Ser Pro Gly 
                165                 170                 175     


Glu Val Pro Pro Gly Thr Ser Pro Ala Cys Ile Leu Ala Thr Trp Pro 
            180                 185                 190         


Pro Gly Leu Leu Val Leu Leu Trp Gln Glu Thr Thr Leu Pro Glu His 
        195                 200                 205             


Cys Phe Ser Trp Thr Leu Glu Ala Gly Thr Gly 
    210                 215                 


<210>  529
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  529

Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210>  530
<211>  1104
<212>  PRT
<213>  Homo sapiens

<400>  530

Met Ser Phe Arg Ala Ala Arg Leu Ser Met Arg Asn Arg Arg Asn Asp 
1               5                   10                  15      


Thr Leu Asp Ser Thr Arg Thr Leu Tyr Ser Ser Ala Ser Arg Ser Thr 
            20                  25                  30          


Asp Leu Ser Tyr Ser Glu Ser Asp Leu Val Asn Phe Ile Gln Ala Asn 
        35                  40                  45              


Phe Lys Lys Arg Glu Cys Val Phe Phe Thr Lys Asp Ser Lys Ala Thr 
    50                  55                  60                  


Glu Asn Val Cys Lys Cys Gly Tyr Ala Gln Ser Gln His Met Glu Gly 
65                  70                  75                  80  


Thr Gln Ile Asn Gln Ser Glu Lys Trp Asn Tyr Lys Lys His Thr Lys 
                85                  90                  95      


Glu Phe Pro Thr Asp Ala Phe Gly Asp Ile Gln Phe Glu Thr Leu Gly 
            100                 105                 110         


Lys Lys Gly Lys Tyr Ile Arg Leu Ser Cys Asp Thr Asp Ala Glu Ile 
        115                 120                 125             


Leu Tyr Glu Leu Leu Thr Gln His Trp His Leu Lys Thr Pro Asn Leu 
    130                 135                 140                 


Val Ile Ser Val Thr Gly Gly Ala Lys Asn Phe Ala Leu Lys Pro Arg 
145                 150                 155                 160 


Met Arg Lys Ile Phe Ser Arg Leu Ile Tyr Ile Ala Gln Ser Lys Gly 
                165                 170                 175     


Ala Trp Ile Leu Thr Gly Gly Thr His Tyr Gly Leu Met Lys Tyr Ile 
            180                 185                 190         


Gly Glu Val Val Arg Asp Asn Thr Ile Ser Arg Ser Ser Glu Glu Asn 
        195                 200                 205             


Ile Val Ala Ile Gly Ile Ala Ala Trp Gly Met Val Ser Asn Arg Asp 
    210                 215                 220                 


Thr Leu Ile Arg Asn Cys Asp Ala Glu Gly Tyr Phe Leu Ala Gln Tyr 
225                 230                 235                 240 


Leu Met Asp Asp Phe Thr Arg Asp Pro Leu Tyr Ile Leu Asp Asn Asn 
                245                 250                 255     


His Thr His Leu Leu Leu Val Asp Asn Gly Cys His Gly His Pro Thr 
            260                 265                 270         


Val Glu Ala Lys Leu Arg Asn Gln Leu Glu Lys Tyr Ile Ser Glu Arg 
        275                 280                 285             


Thr Ile Gln Asp Ser Asn Tyr Gly Gly Lys Ile Pro Ile Val Cys Phe 
    290                 295                 300                 


Ala Gln Gly Gly Gly Lys Glu Thr Leu Lys Ala Ile Asn Thr Ser Ile 
305                 310                 315                 320 


Lys Asn Lys Ile Pro Cys Val Val Val Glu Gly Ser Gly Gln Ile Ala 
                325                 330                 335     


Asp Val Ile Ala Ser Leu Val Glu Val Glu Asp Ala Leu Thr Ser Ser 
            340                 345                 350         


Ala Val Lys Glu Lys Leu Val Arg Phe Leu Pro Arg Thr Val Ser Arg 
        355                 360                 365             


Leu Pro Glu Glu Glu Thr Glu Ser Trp Ile Lys Trp Leu Lys Glu Ile 
    370                 375                 380                 


Leu Glu Cys Ser His Leu Leu Thr Val Ile Lys Met Glu Glu Ala Gly 
385                 390                 395                 400 


Asp Glu Ile Val Ser Asn Ala Ile Ser Tyr Ala Leu Tyr Lys Ala Phe 
                405                 410                 415     


Ser Thr Ser Glu Gln Asp Lys Asp Asn Trp Asn Gly Gln Leu Lys Leu 
            420                 425                 430         


Leu Leu Glu Trp Asn Gln Leu Asp Leu Ala Asn Asp Glu Ile Phe Thr 
        435                 440                 445             


Asn Asp Arg Arg Trp Glu Ser Ala Asp Leu Gln Glu Val Met Phe Thr 
    450                 455                 460                 


Ala Leu Ile Lys Asp Arg Pro Lys Phe Val Arg Leu Phe Leu Glu Asn 
465                 470                 475                 480 


Gly Leu Asn Leu Arg Lys Phe Leu Thr His Asp Val Leu Thr Glu Leu 
                485                 490                 495     


Phe Ser Asn His Phe Ser Thr Leu Val Tyr Arg Asn Leu Gln Ile Ala 
            500                 505                 510         


Lys Asn Ser Tyr Asn Asp Ala Leu Leu Thr Phe Val Trp Lys Leu Val 
        515                 520                 525             


Ala Asn Phe Arg Arg Gly Phe Arg Lys Glu Asp Arg Asn Gly Arg Asp 
    530                 535                 540                 


Glu Met Asp Ile Glu Leu His Asp Val Ser Pro Ile Thr Arg His Pro 
545                 550                 555                 560 


Leu Gln Ala Leu Phe Ile Trp Ala Ile Leu Gln Asn Lys Lys Glu Leu 
                565                 570                 575     


Ser Lys Val Ile Trp Glu Gln Thr Arg Gly Cys Thr Leu Ala Ala Leu 
            580                 585                 590         


Gly Ala Ser Lys Leu Leu Lys Thr Leu Ala Lys Val Lys Asn Asp Ile 
        595                 600                 605             


Asn Ala Ala Gly Glu Ser Glu Glu Leu Ala Asn Glu Tyr Glu Thr Arg 
    610                 615                 620                 


Ala Val Glu Leu Phe Thr Glu Cys Tyr Ser Ser Asp Glu Asp Leu Ala 
625                 630                 635                 640 


Glu Gln Leu Leu Val Tyr Ser Cys Glu Ala Trp Gly Gly Ser Asn Cys 
                645                 650                 655     


Leu Glu Leu Ala Val Glu Ala Thr Asp Gln His Phe Ile Ala Gln Pro 
            660                 665                 670         


Gly Val Gln Asn Phe Leu Ser Lys Gln Trp Tyr Gly Glu Ile Ser Arg 
        675                 680                 685             


Asp Thr Lys Asn Trp Lys Ile Ile Leu Cys Leu Phe Ile Ile Pro Leu 
    690                 695                 700                 


Val Gly Cys Gly Phe Val Ser Phe Arg Lys Lys Pro Val Asp Lys His 
705                 710                 715                 720 


Lys Lys Leu Leu Trp Tyr Tyr Val Ala Phe Phe Thr Ser Pro Phe Val 
                725                 730                 735     


Val Phe Ser Trp Asn Val Val Phe Tyr Ile Ala Phe Leu Leu Leu Phe 
            740                 745                 750         


Ala Tyr Val Leu Leu Met Asp Phe His Ser Val Pro His Pro Pro Glu 
        755                 760                 765             


Leu Val Leu Tyr Ser Leu Val Phe Val Leu Phe Cys Asp Glu Val Arg 
    770                 775                 780                 


Gln Trp Tyr Val Asn Gly Val Asn Tyr Phe Thr Asp Leu Trp Asn Val 
785                 790                 795                 800 


Met Asp Thr Leu Gly Leu Phe Tyr Phe Ile Ala Gly Ile Val Phe Arg 
                805                 810                 815     


Leu His Ser Ser Asn Lys Ser Ser Leu Tyr Ser Gly Arg Val Ile Phe 
            820                 825                 830         


Cys Leu Asp Tyr Ile Ile Phe Thr Leu Arg Leu Ile His Ile Phe Thr 
        835                 840                 845             


Val Ser Arg Asn Leu Gly Pro Lys Ile Ile Met Leu Gln Arg Met Leu 
    850                 855                 860                 


Ile Asp Val Phe Phe Phe Leu Phe Leu Phe Ala Val Trp Met Val Ala 
865                 870                 875                 880 


Phe Gly Val Ala Arg Gln Gly Ile Leu Arg Gln Asn Glu Gln Arg Trp 
                885                 890                 895     


Arg Trp Ile Phe Arg Ser Val Ile Tyr Glu Pro Tyr Leu Ala Met Phe 
            900                 905                 910         


Gly Gln Val Pro Ser Asp Val Asp Gly Thr Thr Tyr Asp Phe Ala His 
        915                 920                 925             


Cys Thr Phe Thr Gly Asn Glu Ser Lys Pro Leu Cys Val Glu Leu Asp 
    930                 935                 940                 


Glu His Asn Leu Pro Arg Phe Pro Glu Trp Ile Thr Ile Pro Leu Val 
945                 950                 955                 960 


Cys Ile Tyr Met Leu Ser Thr Asn Ile Leu Leu Val Asn Leu Leu Val 
                965                 970                 975     


Ala Met Phe Gly Tyr Thr Val Gly Thr Val Gln Glu Asn Asn Asp Gln 
            980                 985                 990         


Val Trp Lys Phe Gln Arg Tyr Phe  Leu Val Gln Glu Tyr  Cys Ser Arg 
        995                 1000                 1005             


Leu Asn  Ile Pro Phe Pro Phe  Ile Val Phe Ala Tyr  Phe Tyr Met 
    1010                 1015                 1020             


Val Val  Lys Lys Cys Phe Lys  Cys Cys Cys Lys Glu  Lys Asn Met 
    1025                 1030                 1035             


Glu Ser  Ser Val Cys Cys Phe  Lys Asn Glu Asp Asn  Glu Thr Leu 
    1040                 1045                 1050             


Ala Trp  Glu Gly Val Met Lys  Glu Asn Tyr Leu Val  Lys Ile Asn 
    1055                 1060                 1065             


Thr Lys  Ala Asn Asp Thr Ser  Glu Glu Met Arg His  Arg Phe Arg 
    1070                 1075                 1080             


Gln Leu  Asp Thr Lys Leu Asn  Asp Leu Lys Gly Leu  Leu Lys Glu 
    1085                 1090                 1095             


Ile Ala  Asn Lys Ile Lys 
    1100                 


<210>  531
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  531

Met Gln Cys Phe Ser Phe Ile Lys Thr Met Met Ile Leu Phe Asn Leu 
1               5                   10                  15      


Leu Ile Phe Leu Cys Gly Ala Ala Leu Leu Ala Val Gly Ile Trp Val 
            20                  25                  30          


Ser Ile Asp Gly Ala Ser Phe Leu Lys Ile Phe Gly Pro Leu Ser Ser 
        35                  40                  45              


Ser Ala Met Gln Phe Val Asn Val Gly Tyr Phe Leu Ile Ala Ala Gly 
    50                  55                  60                  


Val Val Val Phe Ala Leu Gly Phe Leu Gly Cys Tyr Gly Ala Lys Thr 
65                  70                  75                  80  


Glu Ser Lys Cys Ala Leu Val Thr Phe Phe Phe Ile Leu Leu Leu Ile 
                85                  90                  95      


Phe Ile Ala Glu Val Ala Ala Ala Val Val Ala Leu Val Tyr Thr Thr 
            100                 105                 110         


Met Ala Glu His Phe Leu Thr Leu Leu Val Val Pro Ala Ile Lys Lys 
        115                 120                 125             


Asp Tyr Gly Ser Gln Glu Asp Phe Thr Gln Val Trp Asn Thr Thr Met 
    130                 135                 140                 


Lys Gly Leu Lys Cys Cys Gly Phe Thr Asn Tyr Thr Asp Phe Glu Asp 
145                 150                 155                 160 


Ser Pro Tyr Phe Lys Glu Asn Ser Ala Phe Pro Pro Phe Cys Cys Asn 
                165                 170                 175     


Asp Asn Val Thr Asn Thr Ala Asn Glu Thr Cys Thr Lys Gln Lys Ala 
            180                 185                 190         


His Asp Gln Lys Val Glu Gly Cys Phe Asn Gln Leu Leu Tyr Asp Ile 
        195                 200                 205             


Arg Thr Asn Ala Val Thr Val Gly Gly Val Ala Ala Gly Ile Gly Gly 
    210                 215                 220                 


Leu Glu Leu Ala Ala Met Ile Val Ser Met Tyr Leu Tyr Cys Asn Leu 
225                 230                 235                 240 


Gln 
    


<210>  532
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  532

Met Ala His Tyr Lys Thr Glu Gln Asp Asp Trp Leu Ile Ile Tyr Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Val Phe Asn Phe Phe Phe Trp Val Gly Gly Ala 
            20                  25                  30          


Ala Val Leu Ala Val Gly Ile Trp Thr Leu Val Glu Lys Ser Gly Tyr 
        35                  40                  45              


Leu Ser Val Leu Ala Ser Ser Thr Phe Ala Ala Ser Ala Tyr Ile Leu 
    50                  55                  60                  


Ile Phe Ala Gly Val Leu Val Met Val Thr Gly Phe Leu Gly Phe Gly 
65                  70                  75                  80  


Ala Ile Leu Trp Glu Arg Lys Gly Cys Leu Ser Thr Tyr Phe Cys Leu 
                85                  90                  95      


Leu Leu Val Ile Phe Leu Val Glu Leu Val Ala Gly Val Leu Ala His 
            100                 105                 110         


Val Tyr Tyr Gln Arg Leu Ser Asp Glu Leu Lys Gln His Leu Asn Arg 
        115                 120                 125             


Thr Leu Ala Glu Asn Tyr Gly Gln Pro Gly Ala Thr Gln Ile Thr Ala 
    130                 135                 140                 


Ser Val Asp Arg Leu Gln Gln Asp Phe Lys Cys Cys Gly Ser Asn Ser 
145                 150                 155                 160 


Ser Ala Asp Trp Gln His Ser Thr Tyr Ile Leu Leu Arg Glu Ala Glu 
                165                 170                 175     


Gly Arg Gln Val Pro Asp Ser Cys Cys Lys Thr Val Val Val Arg Cys 
            180                 185                 190         


Gly Gln Arg Ala His Pro Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Leu Thr Lys Leu Glu Gln Phe Leu Ala Asp His Leu Leu Leu Met Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Val Ala Cys Leu Gln Ile Cys Gly Met Val Leu 
225                 230                 235                 240 


Thr Cys Cys Leu His Gln Arg Leu Gln Arg His Phe Tyr 
                245                 250             


<210>  533
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  533

Met Ala Gly Val Ser Tyr Ala Ala Pro Trp Trp Val Ser Leu Leu His 
1               5                   10                  15      


Arg Leu Pro His Phe Asp Leu Ser Trp Glu Ala Thr Ser Ser Gln Phe 
            20                  25                  30          


Arg Pro Glu Asp Thr Asp Tyr Gln Gln Ala Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Ala Ala Leu Ala Cys Leu Ala Leu Asp Leu Leu Phe Leu Leu Phe Tyr 
    50                  55                  60                  


Ser Phe Trp Leu Cys Cys Arg Arg Arg Lys Ser Glu Glu His Leu Asp 
65                  70                  75                  80  


Ala Asp Cys Cys Cys Thr Ala Trp Cys Val Ile Ile Ala Thr Leu Val 
                85                  90                  95      


Cys Ser Ala Gly Ile Ala Val Gly Phe Tyr Gly Asn Gly Glu Thr Ser 
            100                 105                 110         


Asp Gly Ile His Arg Ala Thr Tyr Ser Leu Arg His Ala Asn Arg Thr 
        115                 120                 125             


Val Ala Gly Val Gln Asp Arg Val Trp Asp Thr Ala Val Gly Leu Asn 
    130                 135                 140                 


His Thr Ala Glu Pro Ser Leu Gln Thr Leu Glu Arg Gln Leu Ala Gly 
145                 150                 155                 160 


Arg Pro Glu Pro Leu Arg Ala Val Gln Arg Leu Gln Gly Leu Leu Glu 
                165                 170                 175     


Thr Leu Leu Gly Tyr Thr Ala Ala Ile Pro Phe Trp Arg Asn Thr Ala 
            180                 185                 190         


Val Ser Leu Glu Val Leu Ala Glu Gln Val Asp Leu Tyr Asp Trp Tyr 
        195                 200                 205             


Arg Trp Leu Gly Tyr Leu Gly Leu Leu Leu Leu Asp Val Ile Ile Cys 
    210                 215                 220                 


Leu Leu Val Leu Val Gly Leu Ile Arg Ser Ser Lys Gly Ile Leu Val 
225                 230                 235                 240 


Gly Val Cys Leu Leu Gly Val Leu Ala Leu Val Ile Ser Trp Gly Ala 
                245                 250                 255     


Leu Gly Leu Glu Leu Ala Val Ser Val Gly Ser Ser Asp Phe Cys Val 
            260                 265                 270         


Asp Pro Asp Ala Tyr Val Thr Lys Met Val Glu Glu Tyr Ser Val Leu 
        275                 280                 285             


Ser Gly Asp Ile Leu Gln Tyr Tyr Leu Ala Cys Ser Pro Arg Ala Ala 
    290                 295                 300                 


Asn Pro Phe Gln Gln Lys Leu Ser Gly Ser His Lys Ala Leu Val Glu 
305                 310                 315                 320 


Met Gln Asp Val Val Ala Glu Leu Leu Arg Thr Val Pro Trp Glu Gln 
                325                 330                 335     


Pro Ala Thr Lys Asp Pro Leu Leu Arg Val Gln Glu Val Leu Asn Gly 
            340                 345                 350         


Thr Glu Val Asn Leu Gln His Leu Thr Ala Leu Val Asp Cys Arg Ser 
        355                 360                 365             


Leu His Leu Asp Tyr Val Gln Ala Leu Thr Gly Phe Cys Tyr Asp Gly 
    370                 375                 380                 


Val Glu Gly Leu Ile Tyr Leu Ala Leu Phe Ser Phe Val Thr Ala Leu 
385                 390                 395                 400 


Met Phe Ser Ser Ile Val Cys Ser Val Pro His Thr Trp Gln Gln Lys 
                405                 410                 415     


Arg Gly Pro Asp Glu Asp Gly Glu Glu Glu Ala Ala Pro Gly Pro Arg 
            420                 425                 430         


Gln Ala His Asp Ser Leu Tyr Arg Val His Met Pro Ser Leu Tyr Ser 
        435                 440                 445             


Cys Gly Ser Ser Tyr Gly Ser Glu Thr Ser Ile Pro Ala Ala Ala His 
    450                 455                 460                 


Thr Val Ser Asn Ala Pro Val Thr Glu Tyr Met Ser Gln Asn Ala Asn 
465                 470                 475                 480 


Phe Gln Asn Pro Arg Cys Glu Asn Thr Pro Leu Ile Gly Arg Glu Ser 
                485                 490                 495     


Pro Pro Pro Ser Tyr Thr Ser Ser Met Arg Ala Lys Tyr Leu Ala Thr 
            500                 505                 510         


Ser Gln Pro Arg Pro Asp Ser Ser Gly Ser His 
        515                 520             


<210>  534
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  534

Met Val Phe Ala Phe Trp Lys Val Phe Leu Ile Leu Ser Cys Leu Ala 
1               5                   10                  15      


Gly Gln Val Ser Val Val Gln Val Thr Ile Pro Asp Gly Phe Val Asn 
            20                  25                  30          


Val Thr Val Gly Ser Asn Val Thr Leu Ile Cys Ile Tyr Thr Thr Thr 
        35                  40                  45              


Val Ala Ser Arg Glu Gln Leu Ser Ile Gln Trp Ser Phe Phe His Lys 
    50                  55                  60                  


Lys Glu Met Glu Pro Ile Ser His Ser Ser Cys Leu Ser Thr Glu Gly 
65                  70                  75                  80  


Met Glu Glu Lys Ala Val Ser Gln Cys Leu Lys Met Thr His Ala Arg 
                85                  90                  95      


Asp Ala Arg Gly Arg Cys Ser Trp Thr Ser Glu Ile Tyr Phe Ser Gln 
            100                 105                 110         


Gly Gly Gln Ala Val Ala Ile Gly Gln Phe Lys Asp Arg Ile Thr Gly 
        115                 120                 125             


Ser Asn Asp Pro Gly Asn Ala Ser Ile Thr Ile Ser His Met Gln Pro 
    130                 135                 140                 


Ala Asp Ser Gly Ile Tyr Ile Cys Asp Val Asn Asn Pro Pro Asp Phe 
145                 150                 155                 160 


Leu Gly Gln Asn Gln Gly Ile Leu Asn Val Ser Val Leu Val Lys Pro 
                165                 170                 175     


Ser Lys Pro Leu Cys Ser Val Gln Gly Arg Pro Glu Thr Gly His Thr 
            180                 185                 190         


Ile Ser Leu Ser Cys Leu Ser Ala Leu Gly Thr Pro Ser Pro Val Tyr 
        195                 200                 205             


Tyr Trp His Lys Leu Glu Gly Arg Asp Ile Val Pro Val Lys Glu Asn 
    210                 215                 220                 


Phe Asn Pro Thr Thr Gly Ile Leu Val Ile Gly Asn Leu Thr Asn Phe 
225                 230                 235                 240 


Glu Gln Gly Tyr Tyr Gln Cys Thr Ala Ile Asn Arg Leu Gly Asn Ser 
                245                 250                 255     


Ser Cys Glu Ile Asp Leu Thr Ser Ser His Pro Glu Val Gly Ile Ile 
            260                 265                 270         


Val Gly Ala Leu Ile Gly Ser Leu Val Gly Ala Ala Ile Ile Ile Ser 
        275                 280                 285             


Val Val Cys Phe Ala Arg Asn Lys Ala Lys Ala Lys Ala Lys Glu Arg 
    290                 295                 300                 


Asn Ser Lys Thr Ile Ala Glu Leu Glu Pro Met Thr Lys Ile Asn Pro 
305                 310                 315                 320 


Arg Gly Glu Ser Glu Ala Met Pro Arg Glu Asp Ala Thr Gln Leu Glu 
                325                 330                 335     


Val Thr Leu Pro Ser Ser Ile His Glu Thr Gly Pro Asp Thr Ile Gln 
            340                 345                 350         


Glu Pro Asp Tyr Glu Pro Lys Pro Thr Gln Glu Pro Ala Pro Glu Pro 
        355                 360                 365             


Ala Pro Gly Ser Glu Pro Met Ala Val Pro Asp Leu Asp Ile Glu Leu 
    370                 375                 380                 


Glu Leu Glu Pro Glu Thr Gln Ser Glu Leu Glu Pro Glu Pro Glu Pro 
385                 390                 395                 400 


Glu Pro Glu Ser Glu Pro Gly Val Val Val Glu Pro Leu Ser Glu Asp 
                405                 410                 415     


Glu Lys Gly Val Val Lys Ala 
            420             


<210>  535
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  535

Met Val Phe Ala Phe Trp Lys Val Phe Leu Ile Leu Ser Cys Leu Ala 
1               5                   10                  15      


Gly Gln Val Ser Val Val Gln Val Thr Ile Pro Asp Gly Phe Val Asn 
            20                  25                  30          


Val Thr Val Gly Ser Asn Val Thr Leu Ile Cys Ile Tyr Thr Thr Thr 
        35                  40                  45              


Val Ala Ser Arg Glu Gln Leu Ser Ile Gln Trp Ser Phe Phe His Lys 
    50                  55                  60                  


Lys Glu Met Glu Pro Ile Ser Ile Tyr Phe Ser Gln Gly Gly Gln Ala 
65                  70                  75                  80  


Val Ala Ile Gly Gln Phe Lys Asp Arg Ile Thr Gly Ser Asn Asp Pro 
                85                  90                  95      


Gly Asn Ala Ser Ile Thr Ile Ser His Met Gln Pro Ala Asp Ser Gly 
            100                 105                 110         


Ile Tyr Ile Cys Asp Val Asn Asn Pro Pro Asp Phe Leu Gly Gln Asn 
        115                 120                 125             


Gln Gly Ile Leu Asn Val Ser Val Leu Val Lys Pro Ser Lys Pro Leu 
    130                 135                 140                 


Cys Ser Val Gln Gly Arg Pro Glu Thr Gly His Thr Ile Ser Leu Ser 
145                 150                 155                 160 


Cys Leu Ser Ala Leu Gly Thr Pro Ser Pro Val Tyr Tyr Trp His Lys 
                165                 170                 175     


Leu Glu Gly Arg Asp Ile Val Pro Val Lys Glu Asn Phe Asn Pro Thr 
            180                 185                 190         


Thr Gly Ile Leu Val Ile Gly Asn Leu Thr Asn Phe Glu Gln Gly Tyr 
        195                 200                 205             


Tyr Gln Cys Thr Ala Ile Asn Arg Leu Gly Asn Ser Ser Cys Glu Ile 
    210                 215                 220                 


Asp Leu Thr Ser Ser His Pro Glu Val Gly Ile Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gly Ser Leu Val Gly Ala Ala Ile Ile Ile Ser Val Val Cys Phe 
                245                 250                 255     


Ala Arg Asn Lys Ala Lys Ala Lys Ala Lys Glu Arg Asn Ser Lys Thr 
            260                 265                 270         


Ile Ala Glu Leu Glu Pro Met Thr Lys Ile Asn Pro Arg Gly Glu Ser 
        275                 280                 285             


Glu Ala Met Pro Arg Glu Asp Ala Thr Gln Leu Glu Val Thr Leu Pro 
    290                 295                 300                 


Ser Ser Ile His Glu Thr Gly Pro Asp Thr Ile Gln Glu Pro Asp Tyr 
305                 310                 315                 320 


Glu Pro Lys Pro Thr Gln Glu Pro Ala Pro Glu Pro Ala Pro Gly Ser 
                325                 330                 335     


Glu Pro Met Ala Val Pro Asp Leu Asp Ile Glu Leu Glu Leu Glu Pro 
            340                 345                 350         


Glu Thr Gln Ser Glu Leu Glu Pro Glu Pro Glu Pro Glu Pro Glu Ser 
        355                 360                 365             


Glu Pro Gly Val Val Val Glu Pro Leu Ser Glu Asp Glu Lys Gly Val 
    370                 375                 380                 


Val Lys Ala 
385         


<210>  536
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  536

Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly 
1               5                   10                  15      


Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr 
            20                  25                  30          


Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu 
        35                  40                  45              


Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr 
    50                  55                  60                  


Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro 
65                  70                  75                  80  


Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe 
                85                  90                  95      


Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr 
            100                 105                 110         


Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr 
        115                 120                 125             


Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys 
    130                 135                 140                 


Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn 
145                 150                 155                 160 


Ser Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala 
                165                 170                 175     


Leu Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
            180                 185         


<210>  537
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  537

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu 
        35                  40                  45              


Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val 
    50                  55                  60                  


Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn 
65                  70                  75                  80  


Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser 
                85                  90                  95      


Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu 
            100                 105                 110         


Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu 
        115                 120                 125             


Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Leu 
    130                 135                 140                 


Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro Leu Ser 
145                 150                 155                 160 


Pro Tyr Leu Met Leu Lys 
                165     


<210>  538
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  538

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  539
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  539

Met Ala Gly Ala Ile Ile Glu Asn Met Ser Thr Lys Lys Leu Cys Ile 
1               5                   10                  15      


Val Gly Gly Ile Leu Leu Val Phe Gln Ile Ile Ala Phe Leu Val Gly 
            20                  25                  30          


Gly Leu Ile Gly Pro Thr Thr Ala Val Ser Tyr Met Ser Val Lys Cys 
        35                  40                  45              


Val Asp Ala Arg Lys Asn His His Lys Thr Lys Trp Phe Val Pro Trp 
    50                  55                  60                  


Gly Pro Asn His Cys Asp Lys Ile Arg Asp Ile Glu Glu Ala Ile Pro 
65                  70                  75                  80  


Arg Glu Ile Glu Ala Asn Asp Ile Val Phe Ser Val His Ile Pro Leu 
                85                  90                  95      


Pro His Met Glu Met Ser Pro Trp Phe Gln Phe Met Leu Phe Ile Leu 
            100                 105                 110         


Gln Leu Asp Ile Ala Phe Lys Leu Asn Asn Gln Ile Arg Glu Asn Ala 
        115                 120                 125             


Glu Val Ser Met Asp Val Ser Leu Ala Tyr Arg Asp Asp Ala Phe Ala 
    130                 135                 140                 


Glu Trp Thr Glu Met Ala His Glu Arg Val Pro Arg Lys Leu Lys Cys 
145                 150                 155                 160 


Thr Phe Thr Ser Pro Lys Thr Pro Glu His Glu Gly Arg Tyr Tyr Glu 
                165                 170                 175     


Cys Asp Val Leu Pro Phe Met Glu Ile Gly Ser Val Ala His Lys Phe 
            180                 185                 190         


Tyr Leu Leu Asn Ile Arg Leu Pro Val Asn Glu Lys Lys Lys Ile Asn 
        195                 200                 205             


Val Gly Ile Gly Glu Ile Lys Asp Ile Arg Leu Val Gly Ile His Gln 
    210                 215                 220                 


Asn Gly Gly Phe Thr Lys Val Trp Phe Ala Met Lys Thr Phe Leu Thr 
225                 230                 235                 240 


Pro Ser Ile Phe Ile Ile Met Val Trp Tyr Trp Arg Arg Ile Thr Met 
                245                 250                 255     


Met Ser Arg Pro Pro Val Leu Leu Glu Lys Val Ile Phe Ala Leu Gly 
            260                 265                 270         


Ile Ser Met Thr Phe Ile Asn Ile Pro Val Glu Trp Phe Ser Ile Gly 
        275                 280                 285             


Phe Asp Trp Thr Trp Met Leu Leu Phe Gly Asp Ile Arg Gln Gly Ile 
    290                 295                 300                 


Phe Tyr Ala Met Leu Leu Ser Phe Trp Ile Ile Phe Cys Gly Glu His 
305                 310                 315                 320 


Met Met Asp Gln His Glu Arg Asn His Ile Ala Gly Tyr Trp Lys Gln 
                325                 330                 335     


Val Gly Pro Ile Ala Val Gly Ser Phe Cys Leu Phe Ile Phe Asp Met 
            340                 345                 350         


Cys Glu Arg Gly Val Gln Leu Thr Asn Pro Phe Tyr Ser Ile Trp Thr 
        355                 360                 365             


Thr Asp Ile Gly Thr Glu Leu Ala Met Ala Phe Ile Ile Val Ala Gly 
    370                 375                 380                 


Ile Cys Leu Cys Leu Tyr Phe Leu Phe Leu Cys Phe Met Val Phe Gln 
385                 390                 395                 400 


Val Phe Arg Asn Ile Ser Gly Lys Gln Ser Ser Leu Pro Ala Met Ser 
                405                 410                 415     


Lys Val Arg Arg Leu His Tyr Glu Gly Leu Ile Phe Arg Phe Lys Phe 
            420                 425                 430         


Leu Met Leu Ile Thr Leu Ala Cys Ala Ala Met Thr Val Ile Phe Phe 
        435                 440                 445             


Ile Val Ser Gln Val Thr Glu Gly His Trp Lys Trp Gly Gly Val Thr 
    450                 455                 460                 


Val Gln Val Asn Ser Ala Phe Phe Thr Gly Ile Tyr Gly Met Trp Asn 
465                 470                 475                 480 


Leu Tyr Val Phe Ala Leu Met Phe Leu Tyr Ala Pro Ser His Lys Asn 
                485                 490                 495     


Tyr Gly Glu Asp Gln Ser Asn Gly Met Gln Leu Pro Cys Lys Ser Arg 
            500                 505                 510         


Glu Asp Cys Ala Leu Phe Val Ser Glu Leu Tyr Gln Glu Leu Phe Ser 
        515                 520                 525             


Ala Ser Lys Tyr Ser Phe Ile Asn Asp Asn Ala Ala Ser Gly Ile 
    530                 535                 540             


<210>  540
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  540

Met Ala Gly Ala Ile Ile Glu Asn Met Ser Thr Lys Lys Leu Cys Ile 
1               5                   10                  15      


Val Gly Gly Ile Leu Leu Val Phe Gln Ile Ile Ala Phe Leu Val Gly 
            20                  25                  30          


Gly Leu Ile Gly Glu Asn Ala Glu Val Ser Met Asp Val Ser Leu Ala 
        35                  40                  45              


Tyr Arg Asp Asp Ala Phe Ala Glu Trp Thr Glu Met Ala His Glu Arg 
    50                  55                  60                  


Val Pro Arg Lys Leu Lys Cys Thr Phe Thr Ser Pro Lys Thr Pro Glu 
65                  70                  75                  80  


His Glu Gly Arg Tyr Tyr Glu Cys Asp Val Leu Pro Phe Met Glu Ile 
                85                  90                  95      


Gly Ser Val Ala His Lys Phe Tyr Leu Leu Asn Ile Arg Leu Pro Val 
            100                 105                 110         


Asn Glu Lys Lys Lys Ile Asn Val Gly Ile Gly Glu Ile Lys Asp Ile 
        115                 120                 125             


Arg Leu Val Gly Ile His Gln Asn Gly Gly Phe Thr Lys Val Trp Phe 
    130                 135                 140                 


Ala Met Lys Thr Phe Leu Thr Pro Ser Ile Phe Ile Ile Met Val Trp 
145                 150                 155                 160 


Tyr Trp Arg Arg Ile Thr Met Met Ser Arg Pro Pro Val Leu Leu Glu 
                165                 170                 175     


Lys Val Ile Phe Ala Leu Gly Ile Ser Met Thr Phe Ile Asn Ile Pro 
            180                 185                 190         


Val Glu Trp Phe Ser Ile Gly Phe Asp Trp Thr Trp Met Leu Leu Phe 
        195                 200                 205             


Gly Asp Ile Arg Gln Gly Ile Phe Tyr Ala Met Leu Leu Ser Phe Trp 
    210                 215                 220                 


Ile Ile Phe Cys Gly Glu His Met Met Asp Gln His Glu Arg Asn His 
225                 230                 235                 240 


Ile Ala Gly Tyr Trp Lys Gln Val Gly Pro Ile Ala Val Gly Ser Phe 
                245                 250                 255     


Cys Leu Phe Ile Phe Asp Met Cys Glu Arg Gly Val Gln Leu Thr Asn 
            260                 265                 270         


Pro Phe Tyr Ser Ile Trp Thr Thr Asp Ile Gly Thr Glu Leu Ala Met 
        275                 280                 285             


Ala Phe Ile Ile Val Ala Gly Ile Cys Leu Cys Leu Tyr Phe Leu Phe 
    290                 295                 300                 


Leu Cys Phe Met Val Phe Gln Val Phe Arg Asn Ile Ser Gly Lys Gln 
305                 310                 315                 320 


Ser Ser Leu Pro Ala Met Ser Lys Val Arg Arg Leu His Tyr Glu Gly 
                325                 330                 335     


Leu Ile Phe Arg Phe Lys Phe Leu Met Leu Ile Thr Leu Ala Cys Ala 
            340                 345                 350         


Ala Met Thr Val Ile Phe Phe Ile Val Ser Gln Val Thr Glu Gly His 
        355                 360                 365             


Trp Lys Trp Gly Gly Val Thr Val Gln Val Asn Ser Ala Phe Phe Thr 
    370                 375                 380                 


Gly Ile Tyr Gly Met Trp Asn Leu Tyr Val Phe Ala Leu Met Phe Leu 
385                 390                 395                 400 


Tyr Ala Pro Ser His Lys Asn Tyr Gly Glu Asp Gln Ser Asn Gly Asp 
                405                 410                 415     


Leu Gly Val His Ser Gly Glu Glu Leu Gln Leu Thr Thr Thr Ile Thr 
            420                 425                 430         


His Val Asp Gly Pro Thr Glu Ile Tyr Lys Leu Thr Arg Lys Glu Ala 
        435                 440                 445             


Gln Glu 
    450 


<210>  541
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  541

Met Ala Gly Ala Ile Ile Glu Asn Met Ser Thr Lys Lys Leu Cys Ile 
1               5                   10                  15      


Val Gly Gly Ile Leu Leu Val Phe Gln Ile Ile Ala Phe Leu Val Gly 
            20                  25                  30          


Gly Leu Ile Ala Pro Gly Pro Thr Thr Ala Val Ser Tyr Met Ser Val 
        35                  40                  45              


Lys Cys Val Asp Ala Arg Lys Asn His His Lys Thr Lys Trp Phe Val 
    50                  55                  60                  


Pro Trp Gly Pro Asn His Cys Asp Lys Ile Arg Asp Ile Glu Glu Ala 
65                  70                  75                  80  


Ile Pro Arg Glu Ile Glu Ala Asn Asp Ile Val Phe Ser Val His Ile 
                85                  90                  95      


Pro Leu Pro His Met Glu Met Ser Pro Trp Phe Gln Phe Met Leu Phe 
            100                 105                 110         


Ile Leu Gln Leu Asp Ile Ala Phe Lys Leu Asn Asn Gln Ile Arg Glu 
        115                 120                 125             


Asn Ala Glu Val Ser Met Asp Val Ser Leu Ala Tyr Arg Asp Asp Ala 
    130                 135                 140                 


Phe Ala Glu Trp Thr Glu Met Ala His Glu Arg Val Pro Arg Lys Leu 
145                 150                 155                 160 


Lys Cys Thr Phe Thr Ser Pro Lys Thr Pro Glu His Glu Gly Arg Tyr 
                165                 170                 175     


Tyr Glu Cys Asp Val Leu Pro Phe Met Glu Ile Gly Ser Val Ala His 
            180                 185                 190         


Lys Phe Tyr Leu Leu Asn Ile Arg Leu Pro Val Asn Glu Lys Lys Lys 
        195                 200                 205             


Ile Asn Val Gly Ile Gly Glu Ile Lys Asp Ile Arg Leu Val Gly Ile 
    210                 215                 220                 


His Gln Asn Gly Gly Phe Thr Lys Val Trp Phe Ala Met Lys Thr Phe 
225                 230                 235                 240 


Leu Thr Pro Ser Ile Phe Ile Ile Met Val Trp Tyr Trp Arg Arg Ile 
                245                 250                 255     


Thr Met Met Ser Arg Pro Pro Val Leu Leu Glu Lys Val Ile Phe Ala 
            260                 265                 270         


Leu Gly Ile Ser Met Thr Phe Ile Asn Ile Pro Val Glu Trp Phe Ser 
        275                 280                 285             


Ile Gly Phe Asp Trp Thr Trp Met Leu Leu Phe Gly Asp Ile Arg Gln 
    290                 295                 300                 


Gly Ile Phe Tyr Ala Met Leu Leu Ser Phe Trp Ile Ile Phe Cys Gly 
305                 310                 315                 320 


Glu His Met Met Asp Gln His Glu Arg Asn His Ile Ala Gly Tyr Trp 
                325                 330                 335     


Lys Gln Val Gly Pro Ile Ala Val Gly Ser Phe Cys Leu Phe Ile Phe 
            340                 345                 350         


Asp Met Cys Glu Arg Gly Val Gln Leu Thr Asn Pro Phe Tyr Ser Ile 
        355                 360                 365             


Trp Thr Thr Asp Ile Gly Thr Glu Leu Ala Met Ala Phe Ile Ile Val 
    370                 375                 380                 


Ala Gly Ile Cys Leu Cys Leu Tyr Phe Leu Phe Leu Cys Phe Met Val 
385                 390                 395                 400 


Phe Gln Val Phe Arg Asn Ile Ser Gly Lys Gln Ser Ser Leu Pro Ala 
                405                 410                 415     


Met Ser Lys Val Arg Arg Leu His Tyr Glu Gly Leu Ile Phe Arg Phe 
            420                 425                 430         


Lys Phe Leu Met Leu Ile Thr Leu Ala Cys Ala Ala Met Thr Val Ile 
        435                 440                 445             


Phe Phe Ile Val Ser Gln Val Thr Glu Gly His Trp Lys Trp Gly Gly 
    450                 455                 460                 


Val Thr Val Gln Val Asn Ser Ala Phe Phe Thr Gly Ile Tyr Gly Met 
465                 470                 475                 480 


Trp Asn Leu Tyr Val Phe Ala Leu Met Phe Leu Tyr Ala Pro Ser His 
                485                 490                 495     


Lys Asn Tyr Gly Glu Asp Gln Ser Asn Gly Asp Leu Gly Val His Ser 
            500                 505                 510         


Gly Glu Glu Leu Gln Leu Thr Thr Thr Ile Thr His Val Asp Gly Pro 
        515                 520                 525             


Thr Glu Ile Tyr Lys Leu Thr Arg Lys Glu Ala Gln Glu 
    530                 535                 540     


<210>  542
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  542

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  543
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  543

Met Lys Ala Val Leu Leu Ala Leu Leu Met Ala Gly Leu Ala Leu Gln 
1               5                   10                  15      


Pro Gly Thr Ala Leu Leu Cys Tyr Ser Cys Lys Ala Gln Val Ser Asn 
            20                  25                  30          


Glu Asp Cys Leu Gln Val Glu Asn Cys Thr Gln Leu Gly Glu Gln Cys 
        35                  40                  45              


Trp Thr Ala Arg Ile Arg Ala Val Gly Leu Leu Thr Val Ile Ser Lys 
    50                  55                  60                  


Gly Cys Ser Leu Asn Cys Val Asp Asp Ser Gln Asp Tyr Tyr Val Gly 
65                  70                  75                  80  


Lys Lys Asn Ile Thr Cys Cys Asp Thr Asp Leu Cys Asn Ala Ser Gly 
                85                  90                  95      


Ala His Ala Leu Gln Pro Ala Ala Ala Ile Leu Ala Leu Leu Pro Ala 
            100                 105                 110         


Leu Gly Leu Leu Leu Trp Gly Pro Gly Gln Leu 
        115                 120             


