                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
       Shon, Judy
       Bertozzi, Carolyn R.
       Malaker, Stacy A.
       Pedram, Kavyon
 
<120>  METHODS EMPLOYING MUCIN-SPECIFIC PROTEASES

<130>  STAN-1510WO

<150>  US 62/757585
<151>  2018-11-08

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  863
<212>  PRT
<213>  Escherichia coli

<400>  1

Ala Asp Asn Asn Ser Ala Ile Tyr Phe Asn Thr Ser Gln Pro Ile Asn 
1               5                   10                  15      


Asp Leu Gln Gly Ser Leu Ala Ala Glu Val Lys Phe Ala Gln Ser Gln 
            20                  25                  30          


Ile Leu Pro Ala His Pro Lys Glu Gly Asp Ser Gln Pro His Leu Thr 
        35                  40                  45              


Ser Leu Arg Lys Ser Leu Leu Leu Val Arg Pro Val Lys Ala Asp Asp 
    50                  55                  60                  


Lys Thr Pro Val Gln Val Glu Ala Arg Asp Asp Asn Asn Lys Ile Leu 
65                  70                  75                  80  


Gly Thr Leu Thr Leu Tyr Pro Pro Ser Ser Leu Pro Asp Thr Ile Tyr 
                85                  90                  95      


His Leu Asp Gly Val Pro Glu Gly Gly Ile Asp Phe Thr Pro His Asn 
            100                 105                 110         


Gly Thr Lys Lys Ile Ile Asn Thr Val Ala Glu Val Asn Lys Leu Ser 
        115                 120                 125             


Asp Ala Ser Gly Ser Ser Ile His Ser His Leu Thr Asn Asn Ala Leu 
    130                 135                 140                 


Val Glu Ile His Thr Ala Asn Gly Arg Trp Val Arg Asp Ile Tyr Leu 
145                 150                 155                 160 


Pro Gln Gly Pro Asp Leu Glu Gly Lys Met Val Arg Phe Val Ser Ser 
                165                 170                 175     


Ala Gly Tyr Ser Ser Thr Val Phe Tyr Gly Asp Arg Lys Val Thr Leu 
            180                 185                 190         


Ser Val Gly Asn Thr Leu Leu Phe Lys Tyr Val Asn Gly Gln Trp Phe 
        195                 200                 205             


Arg Ser Gly Glu Leu Glu Asn Asn Arg Ile Thr Tyr Ala Gln His Ile 
    210                 215                 220                 


Trp Ser Ala Glu Leu Pro Ala His Trp Ile Val Pro Gly Leu Asn Leu 
225                 230                 235                 240 


Val Ile Lys Gln Gly Asn Leu Ser Gly Arg Leu Asn Asp Ile Lys Ile 
                245                 250                 255     


Gly Ala Pro Gly Glu Leu Leu Leu His Thr Ile Asp Ile Gly Met Leu 
            260                 265                 270         


Thr Thr Pro Arg Asp Arg Phe Asp Phe Ala Lys Asp Lys Glu Ala His 
        275                 280                 285             


Arg Glu Tyr Phe Gln Thr Ile Pro Val Ser Arg Met Ile Val Asn Asn 
    290                 295                 300                 


Tyr Ala Pro Leu His Leu Lys Glu Val Met Leu Pro Thr Gly Glu Leu 
305                 310                 315                 320 


Leu Thr Asp Met Asp Pro Gly Asn Gly Gly Trp His Ser Gly Thr Met 
                325                 330                 335     


Arg Gln Arg Ile Gly Lys Glu Leu Val Ser His Gly Ile Asp Asn Ala 
            340                 345                 350         


Asn Tyr Gly Leu Asn Ser Thr Ala Gly Leu Gly Glu Asn Ser His Pro 
        355                 360                 365             


Tyr Val Val Ala Gln Leu Ala Ala His Asn Ser Arg Gly Asn Tyr Ala 
    370                 375                 380                 


Asn Gly Ile Gln Val His Gly Gly Ser Gly Gly Gly Gly Ile Val Thr 
385                 390                 395                 400 


Leu Asp Ser Thr Leu Gly Asn Glu Phe Ser His Glu Val Gly His Asn 
                405                 410                 415     


Tyr Gly Leu Gly His Tyr Val Asp Gly Phe Lys Gly Ser Val His Arg 
            420                 425                 430         


Ser Ala Glu Asn Asn Asn Ser Thr Trp Gly Trp Asp Gly Asp Lys Lys 
        435                 440                 445             


Arg Phe Ile Pro Asn Phe Tyr Pro Ser Gln Thr Asn Glu Lys Ser Cys 
    450                 455                 460                 


Leu Asn Asn Gln Cys Gln Glu Pro Phe Asp Gly His Lys Phe Gly Phe 
465                 470                 475                 480 


Asp Ala Met Ala Gly Gly Ser Pro Phe Ser Ala Ala Asn Arg Phe Thr 
                485                 490                 495     


Met Tyr Thr Pro Asn Ser Ser Ala Ile Ile Gln Arg Phe Phe Glu Asn 
            500                 505                 510         


Lys Ala Val Phe Asp Ser Arg Ser Ser Thr Gly Phe Ser Lys Trp Asn 
        515                 520                 525             


Ala Asp Thr Gln Glu Met Glu Pro Tyr Glu His Thr Ile Asp Arg Ala 
    530                 535                 540                 


Glu Gln Ile Thr Ala Ser Val Asn Glu Leu Ser Glu Ser Lys Met Ala 
545                 550                 555                 560 


Glu Leu Met Ala Glu Tyr Ala Val Val Lys Val His Met Trp Asn Gly 
                565                 570                 575     


Asn Trp Thr Arg Asn Ile Tyr Ile Pro Thr Ala Ser Ala Asp Asn Arg 
            580                 585                 590         


Gly Ser Ile Leu Thr Ile Asn His Glu Ala Gly Tyr Asn Ser Tyr Leu 
        595                 600                 605             


Phe Ile Asn Gly Asp Glu Lys Val Val Ser Gln Gly Tyr Lys Lys Ser 
    610                 615                 620                 


Phe Val Ser Asp Gly Gln Phe Trp Lys Glu Arg Asp Val Val Asp Thr 
625                 630                 635                 640 


Arg Glu Ala Arg Lys Pro Glu Gln Phe Gly Val Pro Val Thr Thr Leu 
                645                 650                 655     


Val Gly Tyr Tyr Asp Pro Glu Gly Thr Leu Ser Ser Tyr Ile Tyr Pro 
            660                 665                 670         


Ala Met Tyr Gly Ala Tyr Gly Phe Thr Tyr Ser Asp Asp Ser Gln Asn 
        675                 680                 685             


Leu Ser Asp Asn Asp Cys Gln Leu Gln Val Asp Thr Lys Glu Gly Gln 
    690                 695                 700                 


Leu Arg Phe Arg Leu Ala Asn His Arg Ala Asn Asn Thr Val Met Asn 
705                 710                 715                 720 


Lys Phe His Ile Asn Val Pro Thr Glu Ser Gln Pro Thr Gln Ala Thr 
                725                 730                 735     


Leu Val Cys Asn Asn Lys Ile Leu Asp Thr Lys Ser Leu Thr Pro Ala 
            740                 745                 750         


Pro Glu Gly Leu Thr Tyr Thr Val Asn Gly Gln Ala Leu Pro Ala Lys 
        755                 760                 765             


Glu Asn Glu Gly Cys Ile Val Ser Val Asn Ser Gly Lys Arg Tyr Cys 
    770                 775                 780                 


Leu Pro Val Gly Gln Arg Ser Gly Tyr Ser Leu Pro Asp Trp Ile Val 
785                 790                 795                 800 


Gly Gln Glu Val Tyr Val Asp Ser Gly Ala Lys Ala Lys Val Leu Leu 
                805                 810                 815     


Ser Asp Trp Asp Asn Leu Ser Tyr Asn Arg Ile Gly Glu Phe Val Gly 
            820                 825                 830         


Asn Val Asn Pro Ala Asp Met Lys Lys Val Lys Ala Trp Asn Gly Gln 
        835                 840                 845             


Tyr Leu Asp Phe Ser Lys Pro Arg Ser Met Arg Val Val Tyr Lys 
    850                 855                 860             


<210>  2
<211>  2697
<212>  DNA
<213>  Escherichia coli

<400>  2
atgaacacta aaatgaatga gagatggaga acaccgatga aattaaagta tctgtcatgt       60

acgatccttg cccctctggc gattggggta ttttctgcaa cagctgctga taataattca      120

gccatttatt tcaatacctc ccagcctata aatgatctgc agggttcgtt ggccgcagag      180

gtgaaatttg cacaaagcca gattttaccc gcccatccta aagaagggga tagtcaacca      240

catctgacca gcctgcggaa aagtctgctg cttgtccgtc cggtgaaagc tgatgataaa      300

acacctgttc aggtggaagc ccgcgatgat aataataaaa ttctcggtac gttaaccctt      360

tatcctcctt catcactacc ggatacaatc taccatctgg atggtgttcc ggaaggtggt      420

atcgatttca cacctcataa tggaacgaaa aagatcatta atacggtggc tgaagtaaac      480

aaactcagtg atgccagcgg gagttctatt catagccatc taacaaataa tgcactggtg      540

gagatccata ctgcaaatgg tcgttgggta agagacattt atctgccgca gggacccgac      600

cttgaaggta agatggttcg ctttgtttcg tctgcaggct atagttcaac ggttttttat      660

ggtgatcgaa aagtcacact ctcggtgggt aacactcttc tgttcaaata tgtaaatggt      720

cagtggttcc gctccggtga actggagaat aatcgaatca cttatgctca gcatatttgg      780

agtgctgaac tgcctgcgca ctggatcgtg cctggtttaa acttggtgat taaacagggc      840

aatctgagcg gtcgcctaaa tgatatcaag attggagcac cgggtgagct gttgttgcat      900

acaattgata tcgggatgtt gaccactccc cgggatcgct ttgattttgc caaagacaaa      960

gaagcacata gggaatattt ccagaccatt cctgtaagtc gtatgattgt taataattat     1020

gcgcctctac acctaaagga agttatgtta ccaaccggag agttattgac agatatggat     1080

ccaggaaatg gtgggtggca tagtggtaca atgcgtcaaa gaataggtaa agaattggtt     1140

tcgcatggca ttgataatgc taactatggt ttaaatagta ccgcaggctt aggggagaat     1200

agtcatccat atgtagttgc gcaattagcg gcacataata gccgcggtaa ttatgctaat     1260

ggcatccagg ttcatggtgg ctccggaggt gggggaattg ttactttaga ttccacattg     1320

gggaatgagt tcagtcatga agttggtcat aattatggtc ttggtcatta tgtagatggt     1380

ttcaagggtt ctgtacatcg tagtgcagaa aataacaact caacttgggg atgggatggt     1440

gataaaaaac ggtttattcc taacttttat ccgtctcaaa caaatgaaaa gagttgtctg     1500

aataatcagt gtcaagaacc gtttgatgga cacaaatttg gttttgacgc catggcggga     1560

ggcagccctt tctctgctgc aaaccgtttc acaatgtata ctccgaattc atcggctatc     1620

atccagcgtt tttttgaaaa taaagctgtg ttcgatagcc gttcctccac cggcttcagc     1680

aagtggaatg cagatacgca ggaaatggaa ccgtatgaac acaccattga ccgtgcggag     1740

cagattacgg cttcagtcaa tgagctaagt gaaagcaaaa tggctgagct gatggcagag     1800

tacgctgtcg tcaaagtgca tatgtggaac ggtaactgga caagaaacat ctatatccct     1860

acagcctccg cagataatag aggcagtatc ctgaccatca accatgaggc cggttataat     1920

agttatctgt ttataaatgg tgacgaaaag gtcgtttccc aggggtataa aaagagcttt     1980

gtttccgatg gtcagttctg gaaagaacgt gatgtggttg atactcgtga agcgcgtaag     2040

ccagagcagt ttggtgttcc tgtgacgacc ctggtggggt attacgatcc ggaaggcacg     2100

ctgtcaagct acatctatcc tgcgatgtat ggtgcctatg gcttcactta ttccgatgat     2160

agtcagaatc tatccgataa cgactgccag ctgcaggtgg atacgaaaga agggcagttg     2220

cgattcagac tggctaatca ccgggctaac aacactgtaa tgaataagtt ccatattaac     2280

gtgccaacag aaagtcagcc cacacaggcc acattggttt gcaataacaa gatactggat     2340

accaaatcgc tcacacctgc gccagaagga cttacctata ctgtaaatgg gcaggcactt     2400

ccagcaaaag aaaacgaggg atgcatcgtg tccgtgaatt caggtaaacg ttactgtttg     2460

ccggttggtc aacggtcagg atatagcctt cctgactgga ttgttgggca ggaagtctat     2520

gtcgacagcg gggctaaagc gaaagtgctg ctttctgact gggataacct gtcctataac     2580

aggattggtg agtttgtagg taatgtgaac ccagctgata tgaaaaaagt taaagcctgg     2640

aacggacagt atttggactt cagtaaacct aggtcaatga gggttgtata taaataa        2697


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  CARBOHYD
<222>  (5)..(5)

<400>  3

Arg Pro Pro Ile Thr Gln Ser Ser Leu 
1               5                   


<210>  4
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  CARBOHYD
<222>  (1)..(1)
<223>  The Amino Acid at position 1 is modified with GalNAcalpha

<220>
<221>  CARBOHYD
<222>  (3)..(3)
<223>  The Amino Acid at position 3 is modified with GalNAcalpha

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  METHYLATION

<400>  4

Pro Thr Leu Thr His Asn 
1               5       


<210>  5
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Leu Ser Thr Met Met Ser Pro Thr Thr 
1               5                   


<210>  6
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Ser Thr Asn Ala Ser Thr Val Pro Phe Arg 
1               5                   10  


<210>  7
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  METHYLATION

<400>  7

Pro Thr Leu Thr His Asn 
1               5       


<210>  8
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  CARBOHYD
<222>  (1)..(1)
<223>  The amino acid at position 1 is modified with GalNAcalpha

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  METHYLATION

<400>  8

Pro Thr Leu Thr His Asn 
1               5       


<210>  9
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9
tcagtcatga cgttggtcat aattatg                                           27


<210>  10
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10
actcattccc caatgtgg                                                     18


<210>  11
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  CARBOHYD
<222>  (5)..(5)
<223>  The amino acid at position 5 is modified with GalNAc

<400>  11

Arg Pro Pro Ile Thr Gln Ser Ser Leu 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  CARBOHYD
<222>  (4)..(4)
<223>  The amino acid at position 4 is modified with GalNAc

<400>  12

Ile Pro Val Ser Ser His Asn Ser Leu 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Ser His Asn Ser Leu 
1               5   


<210>  14
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<400>  14

Asp Arg Val Tyr Ile His Pro Phe 
1               5               


<210>  15
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  CARBOHYD
<222>  (5)..(5)

<400>  15

Arg Pro Pro Ile Thr Gln 
1               5       


<210>  16
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  CARBOHYD
<222>  (3)..(3)

<400>  16

Gly Pro Thr Pro Ser Ala Ala 
1               5           


<210>  17
<211>  1372
<212>  PRT
<213>  Escherichia coli

<400>  17

Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Ala Val Ser Glu Leu Ala Arg Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Ile Cys Leu Cys 
        35                  40                  45              


Tyr Ser Gln Ile Ser Gln Ala Gly Ile Val Arg Ser Asp Ile Ala Tyr 
    50                  55                  60                  


Gln Ile Tyr Arg Asp Phe Ala Glu Asn Lys Gly Leu Phe Val Pro Gly 
65                  70                  75                  80  


Ala Asn Asp Ile Pro Val Tyr Asp Lys Asp Gly Lys Leu Val Gly Arg 
                85                  90                  95      


Leu Gly Lys Ala Pro Met Ala Asp Phe Ser Ser Val Ser Ser Asn Gly 
            100                 105                 110         


Val Ala Thr Leu Val Ser Pro Gln Tyr Ile Val Ser Val Lys His Asn 
        115                 120                 125             


Gly Gly Tyr Arg Ser Val Ser Phe Gly Asn Gly Lys Asn Thr Tyr Ser 
    130                 135                 140                 


Leu Val Asp Arg Asn Asn His Pro Ser Ile Asp Phe His Ala Pro Arg 
145                 150                 155                 160 


Leu Asn Lys Leu Val Thr Glu Val Ile Pro Ser Ala Val Thr Ser Glu 
                165                 170                 175     


Gly Thr Lys Ala Asn Ala Tyr Lys Tyr Thr Glu Arg Tyr Thr Ala Phe 
            180                 185                 190         


Tyr Arg Val Gly Ser Gly Thr Gln Tyr Thr Lys Asp Lys Asp Gly Asn 
        195                 200                 205             


Leu Val Lys Val Ala Gly Gly Tyr Ala Phe Lys Thr Gly Gly Thr Thr 
    210                 215                 220                 


Gly Val Pro Leu Ile Ser Asp Ala Thr Ile Val Ser Asn Pro Gly Gln 
225                 230                 235                 240 


Thr Tyr Asn Pro Val Asn Gly Pro Leu Pro Asp Tyr Gly Ala Pro Gly 
                245                 250                 255     


Asp Ser Gly Ser Pro Leu Phe Ala Tyr Asp Lys Gln Gln Lys Lys Trp 
            260                 265                 270         


Val Ile Val Ala Val Leu Arg Ala Tyr Ala Gly Ile Asn Gly Ala Thr 
        275                 280                 285             


Asn Trp Trp Asn Val Ile Pro Thr Asp Tyr Leu Asn Gln Val Met Gln 
    290                 295                 300                 


Asp Asp Phe Asp Ala Pro Val Asp Phe Val Ser Gly Leu Gly Pro Leu 
305                 310                 315                 320 


Asn Trp Thr Tyr Asp Lys Thr Ser Gly Thr Gly Thr Leu Ser Gln Gly 
                325                 330                 335     


Ser Lys Asn Trp Thr Met His Gly Gln Lys Asp Asn Asp Leu Asn Ala 
            340                 345                 350         


Gly Lys Asn Leu Val Phe Ser Gly Gln Asn Gly Ala Ile Ile Leu Lys 
        355                 360                 365             


Asp Ser Val Thr Gln Gly Ala Gly Tyr Leu Glu Phe Lys Asp Ser Tyr 
    370                 375                 380                 


Thr Val Ser Ala Glu Ser Gly Lys Thr Trp Thr Gly Ala Gly Ile Ile 
385                 390                 395                 400 


Thr Asp Lys Gly Thr Asn Val Thr Trp Lys Val Asn Gly Val Ala Gly 
                405                 410                 415     


Asp Asn Leu His Lys Leu Gly Glu Gly Thr Leu Thr Ile Asn Gly Thr 
            420                 425                 430         


Gly Val Asn Pro Gly Gly Leu Lys Thr Gly Asp Gly Ile Val Val Leu 
        435                 440                 445             


Asn Gln Gln Ala Asp Thr Ala Gly Asn Ile Gln Ala Phe Ser Ser Val 
    450                 455                 460                 


Asn Leu Ala Ser Gly Arg Pro Thr Val Val Leu Gly Asp Ala Arg Gln 
465                 470                 475                 480 


Val Asn Pro Asp Asn Ile Ser Trp Gly Tyr Arg Gly Gly Lys Leu Asp 
                485                 490                 495     


Leu Asn Gly Asn Ala Val Thr Phe Thr Arg Leu Gln Ala Ala Asp Tyr 
            500                 505                 510         


Gly Ala Val Ile Thr Asn Asn Ala Gln Gln Lys Ser Gln Leu Leu Leu 
        515                 520                 525             


Asp Leu Lys Ala Gln Asp Thr Asn Val Ser Glu Pro Thr Ile Gly Asn 
    530                 535                 540                 


Ile Ser Pro Phe Gly Gly Thr Gly Thr Pro Gly Asn Leu Tyr Ser Met 
545                 550                 555                 560 


Ile Leu Asn Ser Gln Thr Arg Phe Tyr Ile Leu Lys Ser Ala Ser Tyr 
                565                 570                 575     


Gly Asn Thr Leu Trp Gly Asn Ser Leu Asn Asp Pro Ala Gln Trp Glu 
            580                 585                 590         


Phe Val Gly Met Asp Lys Asn Lys Ala Val Gln Thr Val Lys Asp Arg 
        595                 600                 605             


Ile Leu Ala Gly Arg Ala Lys Gln Pro Val Ile Phe His Gly Gln Leu 
    610                 615                 620                 


Thr Gly Asn Met Asp Val Ala Ile Pro Gln Val Pro Gly Gly Arg Lys 
625                 630                 635                 640 


Val Ile Phe Asp Gly Ser Val Asn Leu Pro Glu Gly Thr Leu Ser Gln 
                645                 650                 655     


Asp Ser Gly Thr Leu Ile Phe Gln Gly His Pro Val Ile His Ala Ser 
            660                 665                 670         


Ile Ser Gly Ser Ala Pro Val Ser Leu Asn Gln Lys Asp Trp Glu Asn 
        675                 680                 685             


Arg Gln Phe Thr Met Lys Thr Leu Ser Leu Lys Asp Ala Asp Phe His 
    690                 695                 700                 


Leu Ser Arg Asn Ala Ser Leu Asn Ser Asp Ile Lys Ser Asp Asn Ser 
705                 710                 715                 720 


His Ile Thr Leu Gly Ser Asp Arg Ala Phe Val Asp Lys Asn Asp Gly 
                725                 730                 735     


Thr Gly Asn Tyr Val Ile Pro Glu Glu Gly Thr Ser Val Pro Asp Thr 
            740                 745                 750         


Val Asn Asp Arg Ser Gln Tyr Glu Gly Asn Ile Thr Leu Asn His Asn 
        755                 760                 765             


Ser Ala Leu Asp Ile Gly Ser Arg Phe Thr Gly Gly Ile Asp Ala Tyr 
    770                 775                 780                 


Asp Ser Ala Val Ser Ile Thr Ser Pro Asp Val Leu Leu Thr Ala Pro 
785                 790                 795                 800 


Gly Ala Phe Ala Gly Ser Ser Leu Thr Val His Asp Gly Gly His Leu 
                805                 810                 815     


Thr Ala Leu Asn Gly Leu Phe Ser Asp Gly His Ile Gln Ala Gly Lys 
            820                 825                 830         


Asn Gly Lys Ile Thr Leu Ser Gly Thr Pro Val Lys Asp Thr Ala Asn 
        835                 840                 845             


Gln Tyr Ala Pro Ala Val Tyr Leu Thr Asp Gly Tyr Asp Leu Thr Gly 
    850                 855                 860                 


Asp Asn Ala Ala Leu Glu Ile Thr Arg Gly Ala His Ala Ser Gly Asp 
865                 870                 875                 880 


Ile His Ala Ser Ala Ala Ser Thr Val Thr Ile Gly Ser Asp Thr Pro 
                885                 890                 895     


Ala Glu Leu Ala Ser Ala Glu Thr Ala Ala Ser Ala Phe Ala Gly Ser 
            900                 905                 910         


Leu Leu Glu Gly Tyr Asn Ala Ala Phe Asn Gly Ala Ile Thr Gly Gly 
        915                 920                 925             


Arg Ala Asp Val Ser Met His Asn Ala Leu Trp Thr Leu Gly Gly Asp 
    930                 935                 940                 


Ser Ala Ile His Ser Leu Thr Val Arg Asn Ser Arg Ile Ser Ser Glu 
945                 950                 955                 960 


Gly Asp Arg Thr Phe Arg Thr Leu Thr Val Asn Lys Leu Asp Ala Thr 
                965                 970                 975     


Gly Ser Asp Phe Val Leu Arg Thr Asp Leu Lys Asn Ala Asp Lys Ile 
            980                 985                 990         


Asn Val Thr Glu Lys Ala Thr Gly  Ser Asp Asn Ser Leu  Asn Val Ser 
        995                 1000                 1005             


Phe Met  Asn Asn Pro Ala Gln  Gly Gln Ala Leu Asn  Ile Pro Leu 
    1010                 1015                 1020             


Val Thr  Ala Pro Ala Gly Thr  Ser Ala Glu Met Phe  Lys Ala Gly 
    1025                 1030                 1035             


Thr Arg  Val Thr Gly Phe Ser  Arg Val Thr Pro Thr  Leu His Val 
    1040                 1045                 1050             


Asp Thr  Ser Gly Gly Asn Thr  Lys Trp Ile Leu Asp  Gly Phe Lys 
    1055                 1060                 1065             


Ala Glu  Ala Asp Lys Ala Ala  Ala Ala Lys Ala Asp  Ser Phe Met 
    1070                 1075                 1080             


Asn Ala  Gly Tyr Lys Asn Phe  Met Thr Glu Val Asn  Asn Leu Asn 
    1085                 1090                 1095             


Lys Arg  Met Gly Asp Leu Arg  Asp Thr Asn Gly Asp  Ala Gly Ala 
    1100                 1105                 1110             


Trp Ala  Arg Ile Met Ser Gly  Ala Gly Ser Ala Asp  Gly Gly Tyr 
    1115                 1120                 1125             


Ser Asp  Asn Tyr Thr His Val  Gln Val Gly Phe Asp  Lys Lys His 
    1130                 1135                 1140             


Glu Leu  Asp Gly Val Asp Leu  Phe Thr Gly Val Thr  Met Thr Tyr 
    1145                 1150                 1155             


Thr Asp  Ser Ser Ala Asp Ser  His Ala Phe Ser Gly  Lys Thr Lys 
    1160                 1165                 1170             


Ser Val  Gly Gly Gly Leu Tyr  Ala Ser Ala Leu Phe  Glu Ser Gly 
    1175                 1180                 1185             


Ala Tyr  Ile Asp Leu Ile Gly  Lys Tyr Ile His His  Asp Asn Asp 
    1190                 1195                 1200             


Tyr Thr  Gly Asn Phe Ala Ser  Leu Gly Thr Lys His  Tyr Asn Thr 
    1205                 1210                 1215             


His Ser  Trp Tyr Ala Gly Ala  Glu Thr Gly Tyr Arg  Tyr His Leu 
    1220                 1225                 1230             


Thr Glu  Asp Thr Phe Ile Glu  Pro Gln Ala Glu Leu  Val Tyr Gly 
    1235                 1240                 1245             


Ala Val  Ser Gly Lys Thr Phe  Arg Trp Lys Asp Gly  Asp Met Asp 
    1250                 1255                 1260             


Leu Ser  Met Lys Asn Arg Asp  Phe Ser Pro Leu Val  Gly Arg Thr 
    1265                 1270                 1275             


Gly Val  Glu Leu Gly Lys Thr  Phe Ser Gly Lys Asp  Trp Ser Val 
    1280                 1285                 1290             


Thr Ala  Arg Ala Gly Thr Ser  Trp Gln Phe Asp Leu  Leu Asn Asn 
    1295                 1300                 1305             


Gly Glu  Thr Val Leu Arg Asp  Ala Ser Gly Glu Lys  Arg Ile Lys 
    1310                 1315                 1320             


Gly Glu  Lys Asp Ser Arg Met  Leu Phe Asn Val Gly  Met Asn Ala 
    1325                 1330                 1335             


Gln Ile  Lys Asp Asn Met Arg  Phe Gly Leu Glu Phe  Glu Lys Ser 
    1340                 1345                 1350             


Ala Phe  Gly Lys Tyr Asn Val  Asp Asn Ala Val Asn  Ala Asn Phe 
    1355                 1360                 1365             


Arg Tyr  Met Phe 
    1370         


<210>  18
<211>  1704
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  18

Leu Ser Ala Tyr Asn Ser Gln Leu Ser Ile Gly Val Gly Glu His Leu 
1               5                   10                  15      


Pro Glu Pro Leu Lys Ile Glu Gly Tyr Gln Tyr Ile Gly Tyr Ile Lys 
            20                  25                  30          


Thr Lys Lys Gln Asp Asn Thr Glu Leu Ser Arg Thr Val Asp Gly Lys 
        35                  40                  45              


Tyr Ser Ala Gln Arg Asp Ser Gln Pro Asn Ser Thr Lys Thr Ser Asp 
    50                  55                  60                  


Val Val His Ser Ala Asp Leu Glu Trp Asn Gln Gly Gln Gly Lys Val 
65                  70                  75                  80  


Ser Leu Gln Gly Glu Ala Ser Gly Asp Asp Gly Leu Ser Glu Lys Ser 
                85                  90                  95      


Ser Ile Ala Ala Asp Asn Leu Ser Ser Asn Asp Ser Phe Ala Ser Gln 
            100                 105                 110         


Val Glu Gln Asn Pro Asp His Lys Gly Glu Ser Val Val Arg Pro Thr 
        115                 120                 125             


Val Pro Glu Gln Gly Asn Pro Val Ser Ala Thr Thr Val Gln Ser Ala 
    130                 135                 140                 


Glu Glu Glu Val Leu Ala Thr Thr Asn Asp Arg Pro Glu Tyr Lys Leu 
145                 150                 155                 160 


Pro Leu Glu Thr Lys Gly Thr Gln Glu Pro Gly His Glu Gly Glu Ala 
                165                 170                 175     


Ala Val Arg Glu Asp Leu Pro Val Tyr Thr Lys Pro Leu Glu Thr Lys 
            180                 185                 190         


Gly Thr Gln Gly Pro Gly His Glu Gly Glu Ala Ala Val Arg Glu Glu 
        195                 200                 205             


Glu Pro Ala Tyr Thr Glu Pro Leu Ala Thr Lys Gly Thr Gln Glu Pro 
    210                 215                 220                 


Gly His Glu Gly Lys Ala Thr Val Arg Glu Glu Thr Leu Glu Tyr Thr 
225                 230                 235                 240 


Glu Pro Val Ala Thr Lys Gly Thr Gln Glu Pro Glu His Glu Gly Glu 
                245                 250                 255     


Ala Ala Val Glu Glu Glu Leu Pro Ala Leu Glu Val Thr Thr Arg Asn 
            260                 265                 270         


Arg Thr Glu Ile Gln Asn Ile Pro Tyr Thr Thr Glu Glu Ile Gln Asp 
        275                 280                 285             


Pro Thr Leu Leu Lys Asn Arg Arg Lys Ile Glu Arg Gln Gly Gln Ala 
    290                 295                 300                 


Gly Thr Arg Thr Ile Gln Tyr Glu Asp Tyr Ile Val Asn Gly Asn Val 
305                 310                 315                 320 


Val Glu Thr Lys Glu Val Ser Arg Thr Glu Val Ala Pro Val Asn Glu 
                325                 330                 335     


Val Val Lys Val Gly Thr Leu Val Lys Val Lys Pro Thr Val Glu Ile 
            340                 345                 350         


Thr Asn Leu Thr Lys Val Glu Asn Lys Lys Ser Ile Thr Val Ser Tyr 
        355                 360                 365             


Asn Leu Ile Asp Thr Thr Ser Ala Tyr Val Ser Ala Lys Thr Gln Val 
    370                 375                 380                 


Phe His Gly Asp Lys Leu Val Lys Glu Val Asp Ile Glu Asn Pro Ala 
385                 390                 395                 400 


Lys Glu Gln Val Ile Ser Gly Leu Asp Tyr Tyr Thr Pro Tyr Thr Val 
                405                 410                 415     


Lys Thr His Leu Thr Tyr Asn Leu Gly Glu Asn Asn Glu Glu Asn Thr 
            420                 425                 430         


Glu Thr Ser Thr Gln Asp Phe Gln Leu Glu Tyr Lys Lys Ile Glu Ile 
        435                 440                 445             


Lys Asp Ile Asp Ser Val Glu Leu Tyr Gly Lys Glu Asn Asp Arg Tyr 
    450                 455                 460                 


Arg Arg Tyr Leu Ser Leu Ser Glu Ala Pro Thr Asp Thr Ala Lys Tyr 
465                 470                 475                 480 


Phe Val Lys Val Lys Ser Asp Arg Phe Lys Glu Met Tyr Leu Pro Val 
                485                 490                 495     


Lys Ser Ile Thr Glu Asn Thr Asp Gly Thr Tyr Lys Val Thr Val Ala 
            500                 505                 510         


Val Asp Gln Leu Val Glu Glu Gly Thr Asp Gly Tyr Lys Asp Asp Tyr 
        515                 520                 525             


Thr Phe Thr Val Ala Lys Ser Lys Ala Glu Gln Pro Gly Val Tyr Thr 
    530                 535                 540                 


Ser Phe Lys Gln Leu Val Thr Ala Met Gln Ser Asn Leu Ser Gly Val 
545                 550                 555                 560 


Tyr Thr Leu Ala Ser Asp Met Thr Ala Asp Glu Val Ser Leu Gly Asp 
                565                 570                 575     


Lys Gln Thr Ser Tyr Leu Thr Gly Ala Phe Thr Gly Ser Leu Ile Gly 
            580                 585                 590         


Ser Asp Gly Thr Lys Ser Tyr Ala Ile Tyr Asp Leu Lys Lys Pro Leu 
        595                 600                 605             


Phe Asp Thr Leu Asn Gly Ala Thr Val Arg Asp Leu Asp Ile Lys Thr 
    610                 615                 620                 


Val Ser Ala Asp Ser Lys Glu Asn Val Ala Ala Leu Ala Lys Ala Ala 
625                 630                 635                 640 


Asn Ser Ala Asn Ile Asn Asn Val Ala Val Glu Gly Lys Ile Ser Gly 
                645                 650                 655     


Ala Lys Ser Val Ala Gly Leu Val Ala Ser Ala Thr Asn Thr Val Ile 
            660                 665                 670         


Glu Asn Ser Ser Phe Thr Gly Lys Leu Ile Ala Asn His Gln Asp Ser 
        675                 680                 685             


Asn Lys Asn Asp Thr Gly Gly Ile Val Gly Asn Ile Thr Gly Asn Ser 
    690                 695                 700                 


Ser Arg Val Asn Lys Val Arg Val Asp Ala Leu Ile Ser Thr Asn Ala 
705                 710                 715                 720 


Arg Asn Asn Asn Gln Thr Ala Gly Gly Ile Val Gly Arg Leu Glu Asn 
                725                 730                 735     


Gly Ala Leu Ile Ser Asn Ser Val Ala Thr Gly Glu Ile Arg Asn Gly 
            740                 745                 750         


Gln Gly Tyr Ser Arg Val Gly Gly Ile Val Gly Ser Thr Trp Gln Asn 
        755                 760                 765             


Gly Arg Val Asn Asn Val Val Ser Asn Val Asp Val Gly Asp Gly Tyr 
    770                 775                 780                 


Val Ile Thr Gly Asp Gln Tyr Ala Ala Ala Asp Val Lys Asn Ala Ser 
785                 790                 795                 800 


Thr Ser Val Asp Asn Arg Lys Ala Asp Arg Phe Ala Thr Lys Leu Ser 
                805                 810                 815     


Lys Asp Gln Ile Asp Ala Lys Val Ala Asp Tyr Gly Ile Thr Val Thr 
            820                 825                 830         


Leu Asp Asp Thr Gly Gln Asp Leu Lys Arg Asn Leu Arg Glu Val Asp 
        835                 840                 845             


Tyr Thr Arg Leu Asn Lys Ala Glu Ala Glu Arg Lys Val Ala Tyr Ser 
    850                 855                 860                 


Asn Ile Glu Lys Leu Met Pro Phe Tyr Asn Lys Asp Leu Val Val His 
865                 870                 875                 880 


Tyr Gly Asn Lys Val Ala Thr Thr Asp Lys Leu Tyr Thr Thr Glu Leu 
                885                 890                 895     


Leu Asp Val Val Pro Met Lys Asp Asp Glu Val Val Thr Asp Ile Asn 
            900                 905                 910         


Asn Lys Lys Asn Ser Ile Asn Lys Val Met Leu His Phe Lys Asp Asn 
        915                 920                 925             


Thr Val Glu Tyr Leu Asp Val Thr Phe Lys Glu Asn Phe Ile Asn Ser 
    930                 935                 940                 


Gln Val Ile Glu Tyr Asn Val Thr Gly Lys Glu Tyr Ile Phe Thr Pro 
945                 950                 955                 960 


Glu Ala Phe Val Ser Asp Tyr Thr Ala Ile Thr Asn Asn Val Leu Ser 
                965                 970                 975     


Asp Leu Gln Asn Val Thr Leu Asn Ser Glu Ala Thr Lys Lys Val Leu 
            980                 985                 990         


Gly Ala Ala Asn Asp Ala Ala Leu  Asp Asn Leu Tyr Leu  Asp Arg Gln 
        995                 1000                 1005             


Phe Glu  Glu Val Lys Ala Asn  Ile Ala Glu His Leu  Arg Lys Val 
    1010                 1015                 1020             


Leu Ala  Met Asp Lys Ser Ile  Asn Thr Thr Gly Asp  Gly Val Val 
    1025                 1030                 1035             


Glu Tyr  Val Ser Glu Lys Ile  Lys Asn Asn Lys Glu  Ala Phe Met 
    1040                 1045                 1050             


Leu Gly  Leu Thr Tyr Met Asn  Arg Trp Tyr Asp Ile  Asn Tyr Gly 
    1055                 1060                 1065             


Lys Met  Asn Thr Lys Asp Leu  Ser Thr Tyr Lys Phe  Asp Phe Asn 
    1070                 1075                 1080             


Gly Asn  Asn Glu Thr Ser Thr  Leu Asp Thr Ile Val  Ala Leu Gly 
    1085                 1090                 1095             


Asn Ser  Gly Leu Asp Asn Leu  Arg Ala Ser Asn Thr  Val Gly Leu 
    1100                 1105                 1110             


Tyr Ala  Asn Lys Leu Ala Ser  Val Lys Gly Glu Asp  Ser Val Phe 
    1115                 1120                 1125             


Asp Phe  Val Glu Ala Tyr Arg  Lys Leu Phe Leu Pro  Asn Lys Thr 
    1130                 1135                 1140             


Asn Asn  Glu Trp Phe Lys Glu  Asn Thr Lys Ala Tyr  Ile Val Glu 
    1145                 1150                 1155             


Met Lys  Ser Asp Ile Ala Glu  Val Arg Glu Lys Gln  Glu Ser Pro 
    1160                 1165                 1170             


Thr Ala  Asp Arg Lys Tyr Ser  Leu Gly Val Tyr Asp  Arg Ile Ser 
    1175                 1180                 1185             


Ala Pro  Ser Trp Gly His Lys  Ser Met Leu Leu Pro  Leu Leu Thr 
    1190                 1195                 1200             


Leu Pro  Glu Glu Ser Val Tyr  Ile Ser Ser Asn Met  Ser Thr Leu 
    1205                 1210                 1215             


Ala Phe  Gly Ser Tyr Glu Arg  Tyr Arg Asp Ser Val  Asp Gly Val 
    1220                 1225                 1230             


Ile Leu  Ser Gly Asp Ala Leu  Arg Thr Tyr Val Arg  Asn Arg Val 
    1235                 1240                 1245             


Asp Ile  Ala Ala Lys Arg His  Arg Asp His Tyr Asp  Ile Trp Tyr 
    1250                 1255                 1260             


Asn Leu  Leu Asp Ser Ala Ser  Lys Glu Lys Leu Phe  Arg Ser Val 
    1265                 1270                 1275             


Ile Val  Tyr Asp Gly Phe Asn  Val Lys Asp Glu Thr  Gly Arg Thr 
    1280                 1285                 1290             


Tyr Trp  Ala Arg Leu Thr Asp  Lys Asn Ile Gly Ser  Ile Lys Glu 
    1295                 1300                 1305             


Phe Phe  Gly Pro Val Gly Lys  Trp Tyr Glu Tyr Asn  Ser Ser Ala 
    1310                 1315                 1320             


Gly Ala  Tyr Ala Asn Gly Ser  Leu Thr His Phe Val  Leu Asp Arg 
    1325                 1330                 1335             


Leu Leu  Asp Ala Tyr Gly Thr  Ser Val Tyr Thr His  Glu Met Val 
    1340                 1345                 1350             


His Asn  Ser Asp Ser Ala Ile  Tyr Phe Glu Gly Asn  Gly Arg Arg 
    1355                 1360                 1365             


Glu Gly  Leu Gly Ala Glu Leu  Tyr Ala Leu Gly Leu  Leu Gln Ser 
    1370                 1375                 1380             


Val Asp  Ser Val Asn Ser His  Ile Leu Ala Leu Asn  Thr Leu Tyr 
    1385                 1390                 1395             


Lys Ala  Glu Lys Asp Asp Leu  Asn Arg Leu His Thr  Tyr Asn Pro 
    1400                 1405                 1410             


Val Glu  Arg Phe Asp Ser Asp  Glu Ala Leu Gln Ser  Tyr Met His 
    1415                 1420                 1425             


Gly Ser  Tyr Asp Val Met Tyr  Thr Leu Asp Ala Met  Glu Ala Lys 
    1430                 1435                 1440             


Ala Ile  Leu Ala Gln Asn Asn  Asp Val Lys Lys Lys  Trp Phe Arg 
    1445                 1450                 1455             


Lys Ile  Glu Asn Tyr Tyr Val  Arg Asp Thr Arg His  Asn Lys Asp 
    1460                 1465                 1470             


Thr His  Ala Gly Asn Lys Val  Arg Pro Leu Thr Asp  Glu Glu Val 
    1475                 1480                 1485             


Ala Asn  Leu Thr Ser Leu Asn  Ser Leu Ile Asp Asn  Asp Ile Ile 
    1490                 1495                 1500             


Asn Arg  Arg Ser Tyr Asp Asp  Ser Arg Glu Tyr Lys  Arg Asn Gly 
    1505                 1510                 1515             


Tyr Tyr  Thr Ile Ser Met Phe  Ser Pro Val Tyr Ala  Ala Leu Ser 
    1520                 1525                 1530             


Asn Ser  Lys Gly Ala Pro Gly  Asp Ile Met Phe Arg  Lys Ile Ala 
    1535                 1540                 1545             


Tyr Glu  Leu Leu Ala Glu Lys  Gly Tyr His Lys Gly  Phe Leu Pro 
    1550                 1555                 1560             


Tyr Val  Ser Asn Gln Tyr Gly  Ala Glu Ala Phe Ala  Ser Gly Ser 
    1565                 1570                 1575             


Lys Thr  Phe Ser Ser Trp His  Gly Arg Asp Val Ala  Leu Val Thr 
    1580                 1585                 1590             


Asp Asp  Leu Val Phe Lys Lys  Val Phe Asn Gly Glu  Tyr Ser Ser 
    1595                 1600                 1605             


Trp Ala  Asp Phe Lys Lys Ala  Met Phe Lys Gln Arg  Ile Asp Lys 
    1610                 1615                 1620             


Gln Asp  Asn Leu Lys Pro Ile  Thr Ile Gln Tyr Glu  Leu Gly Asn 
    1625                 1630                 1635             


Pro Asn  Ser Thr Lys Glu Val  Thr Ile Thr Thr Ala  Ala Gln Met 
    1640                 1645                 1650             


Gln Gln  Leu Ile Asn Glu Ala  Ala Ala Lys Asp Ile  Thr Asn Ile 
    1655                 1660                 1665             


Asp Arg  Ala Thr Ser His Thr  Pro Ala Ser Trp Val  His Leu Leu 
    1670                 1675                 1680             


Lys Gln  Lys Ile Tyr Asn Ala  Tyr Leu Arg Thr Thr  Asp Asp Phe 
    1685                 1690                 1695             


Arg Asn  Ser Ile Tyr Lys 
    1700                 


<210>  19
<211>  834
<212>  PRT
<213>  Bacteroides thetaiotaomicron

<400>  19

Lys Asp Thr Glu Lys Ser Ile Ile Asn Ser Ser Phe Ser Ile Ser Glu 
1               5                   10                  15      


Glu Tyr Leu Ile Gln Asn Leu Asp Lys Ser Ser Thr Ser Val Gln Ile 
            20                  25                  30          


Pro Ile Asn Thr Ser Met Glu Leu Ala Gln Trp Ser Val Ser Tyr Glu 
        35                  40                  45              


Ala Asn Trp Leu Gln Cys Ser Lys Gln Lys Thr Ala Ala Glu Gly Thr 
    50                  55                  60                  


Phe Leu Arg Ile Thr Val Asn Glu Asn Thr Gly Glu Thr Lys Arg Thr 
65                  70                  75                  80  


Ala Asn Ile Lys Val Thr Ser Thr Thr Ala Thr Tyr Thr Ile Thr Val 
                85                  90                  95      


Asn Gln Tyr Ala Lys Gly Glu Val Ile Val Glu Gly Asp Ile Lys Val 
            100                 105                 110         


Thr Pro Thr Gly Gly Lys Ala Ser Glu His Gln Glu Gly Gln Asp Ile 
        115                 120                 125             


Glu Asn Thr Tyr Asp Gly Lys Phe Ser Thr Asp Gly Ala Ala Pro Phe 
    130                 135                 140                 


His Thr Pro Trp Gly Gln Ser Ala Lys Phe Pro Val Thr Leu Glu Tyr 
145                 150                 155                 160 


Tyr Phe Lys Gly Asp Thr Glu Ile Asp Tyr Leu Ile Tyr Tyr Thr Arg 
                165                 170                 175     


Ser Gly Asn Gly Asn Phe Gly Lys Val Lys Val Tyr Thr Thr Thr Asn 
            180                 185                 190         


Pro Asp Arg Ser Asp Tyr Thr Leu Gln Gly Glu Tyr Asp Phe Lys Glu 
        195                 200                 205             


Gln Asn Ala Pro Ser Lys Val Ser Phe Ser Glu Gly Ile Lys Ala Thr 
    210                 215                 220                 


Gly Ile Lys Phe Glu Val Leu Ser Gly Leu Gly Asp Phe Val Ser Cys 
225                 230                 235                 240 


Asp Glu Met Glu Phe Tyr Lys Thr Asn Thr Asp Lys Thr Leu Asp Lys 
                245                 250                 255     


Gln Leu Leu Thr Val Phe Thr Asp Ile Thr Cys Thr Glu Ile Lys Asn 
            260                 265                 270         


Asn Val Thr Asn Glu Gln Ile Gln Ala Leu Pro Asp Tyr Phe Val Arg 
        275                 280                 285             


Ile Ala Glu Ala Val Arg Asp Asn Thr Tyr Asp Lys Trp Glu Lys Glu 
    290                 295                 300                 


Phe Arg Ile Arg Ser Tyr Glu Pro Tyr Ser Asn Ile Ala Glu Trp Ala 
305                 310                 315                 320 


Asp Lys Leu Met Thr Lys Lys Tyr Ser Asp Leu Asp Asn Pro Thr Gly 
                325                 330                 335     


Ile Ser Val Lys Ala Gly Asp Asp Ile Ile Val Leu Val Gly Asp Thr 
            340                 345                 350         


Tyr Gly Gln Asn Ile Ser Met Gln Cys Ile Trp Glu Thr Gly Thr Glu 
        355                 360                 365             


Tyr Lys Gln Thr Ala Ser Ser Gly Asp Val Tyr Met Leu Asn Pro Gly 
    370                 375                 380                 


Val Asn Lys Leu Thr Met Lys Gly Glu Gly Gln Leu Phe Val Met Tyr 
385                 390                 395                 400 


Asn Thr Glu Leu Thr Ser Asn Thr Ala Lys Pro Ile Lys Ile His Ile 
                405                 410                 415     


Pro Leu Gly Ser Gly Thr Val Asn Gly Phe Phe Asp Leu Lys Glu His 
            420                 425                 430         


Lys Thr Asp Glu Lys Tyr Ala Glu Leu Leu Lys Lys Ser Thr His Lys 
        435                 440                 445             


Tyr Phe Cys Ile Arg Gly Glu Lys Ile Met Phe Tyr Phe His Arg Asn 
    450                 455                 460                 


Lys Leu Leu Glu Tyr Val Pro Asn Asn Ile Leu Ser Ala Ile His Leu 
465                 470                 475                 480 


Trp Asp Asn Ile Val Gly Trp Gln Gln Glu Leu Met Gly Ile Asp Asp 
                485                 490                 495     


Val Arg Pro Ser Gln Val Asn Asn His Leu Phe Ala Ile Ser Pro Glu 
            500                 505                 510         


Gly Ser Tyr Met Trp Ala Ser Asp Tyr Gln Ile Gly Phe Val Tyr Thr 
        515                 520                 525             


Tyr Leu Gly Asn Ile Leu Leu Glu Asp Asn Val Met Ala Ala Glu Asp 
    530                 535                 540                 


Asn Ala Trp Gly Pro Ala His Glu Ile Gly His Val His Gln Ala Ala 
545                 550                 555                 560 


Ile Asn Trp Ala Ser Ser Thr Glu Ser Ser Asn Asn Leu Phe Ser Asn 
                565                 570                 575     


Phe Ile Ile Tyr Lys Leu Gly Lys Tyr Lys Ser Arg Gly Asn Gly Leu 
            580                 585                 590         


Gly Ser Val Ala Thr Ala Arg Tyr Ala Asn Gly Gln Ala Trp Tyr Asn 
        595                 600                 605             


Met Gly Asp Ala Thr His Gln Asn Glu Asp Thr Glu Thr His Met Arg 
    610                 615                 620                 


Met Asn Trp Gln Leu Trp Ile Tyr Tyr His Arg Cys Glu Tyr Lys Thr 
625                 630                 635                 640 


Asp Phe Trp Gln Thr Leu Phe Lys Leu Met Arg Glu Val Asn Met Thr 
                645                 650                 655     


Glu Gly Glu Asp Pro Gly Lys Lys Gln Leu Glu Phe Ala Lys Met Ala 
            660                 665                 670         


Ser Lys Ala Ala Asn Gln Asn Leu Thr Asp Phe Phe Glu Met Trp Gly 
        675                 680                 685             


Phe Phe Glu Pro Val Asn Thr Thr Ile Glu Gln Tyr Gly Thr Tyr Lys 
    690                 695                 700                 


Tyr Tyr Val Ser Asp Ala Met Ile Arg Glu Ala Lys Glu Tyr Met Ala 
705                 710                 715                 720 


Gln Phe Pro Ala Pro Lys His Ala Phe Gln Tyr Ile Glu Asp Arg Lys 
                725                 730                 735     


Lys Ser Glu Phe Pro Ser Asn Asp Tyr Arg Tyr Ser Ala Val Gly Asp 
            740                 745                 750         


Val Gly Tyr Tyr Thr Gln Phe Lys Glu Asn Gln Lys Ile Thr Lys Ala 
        755                 760                 765             


Ile Thr Ala Glu Leu Ala Gly Arg Lys Val Ser Ile Gln Asn Gly Asp 
    770                 775                 780                 


Glu Ala Val Ala Phe Glu Leu Arg Glu Asn Asp Glu Asn Gly Lys Leu 
785                 790                 795                 800 


Leu Tyr Phe Ser Thr Phe Thr Thr Phe Glu Ile Pro Ser Ser Ile Leu 
                805                 810                 815     


Met Val Asn Ala Lys Leu Tyr Ala Val Gln Ala Asp Gly Lys Arg Ile 
            820                 825                 830         


Leu Leu 
        


<210>  20
<211>  486
<212>  PRT
<213>  Akkermansia muciniphila

<400>  20

Ala Asn Thr Pro Glu His Ile Gly Asn Asp Leu Lys Leu Phe Lys Asp 
1               5                   10                  15      


Ser Ser Cys Thr Ser Leu Lys Pro Asp Val Lys Asn Thr Ser Ala Phe 
            20                  25                  30          


Gln Ser Asp Ala Met Lys Glu Leu Ala Thr Lys Ile Leu Ala Gly His 
        35                  40                  45              


Tyr Lys Pro Asp Tyr Leu Tyr Ala Glu Tyr Arg Ala Leu Pro Ser Pro 
    50                  55                  60                  


Arg Gln Thr Gly Lys Asn Leu Arg Ile Gly Asp Gly Phe Ser Lys Tyr 
65                  70                  75                  80  


Asp Asn Met Thr Gly Val Tyr Leu Glu Lys Gly Arg His Val Val Leu 
                85                  90                  95      


Val Gly Lys Thr Glu Gly Gln Glu Ile Ser Leu Leu Leu Pro Asn Leu 
            100                 105                 110         


Met Arg Lys Pro Ala Glu Gly Val Gln Pro Thr Lys Asp Pro Asn Gly 
        115                 120                 125             


Trp Gly Leu His Lys Lys Gln Ile Pro Leu Lys Glu Gly Ile Asn Ile 
    130                 135                 140                 


Ile Asp Val Glu Thr Pro Ala Asn Ala Tyr Ile Ser Tyr Phe Thr Glu 
145                 150                 155                 160 


Asp Ala Gly Lys Ala Pro Lys Ile Pro Val His Phe Val Thr Gly Lys 
                165                 170                 175     


Ala Asn Gly Tyr Phe Asp Thr Thr Arg Gly Asp Thr Asn Lys Asp Trp 
            180                 185                 190         


Val Arg Leu Leu Asp Gln Ala Val Ser Pro Ile Met Asp Ala Arg Gly 
        195                 200                 205             


Lys Tyr Ile Gln Val Ala Tyr Pro Val Glu Phe Leu Lys Lys Phe Thr 
    210                 215                 220                 


Lys Asp Arg Gly Thr Glu Leu Ile Asn Ala Tyr Asp Lys Leu Ile Gly 
225                 230                 235                 240 


Ile Gln Tyr Gln Leu Met Gly Leu Asp Lys Tyr Gly Lys Ile Pro Glu 
                245                 250                 255     


Asn Arg Val Leu Ala Arg Val Asn Phe Asn Tyr Tyr Met Phe Arg Asp 
            260                 265                 270         


Gly Asp Gly Val Ala Tyr Leu Gly Asn Asp Gly Thr Met Arg Met Val 
        275                 280                 285             


Thr Asp Pro Glu Asn Val Leu Lys Gly Asp Ala Cys Trp Gly Phe Ser 
    290                 295                 300                 


His Glu Val Gly His Val Met Gln Met Arg Pro Met Thr Trp Gly Gly 
305                 310                 315                 320 


Met Thr Glu Val Ser Asn Asn Ile Phe Ser Leu Gln Ala Ala Ala Lys 
                325                 330                 335     


Thr Gly Asn Glu Ser Arg Leu Lys Arg Gln Gly Ser Tyr Asp Lys Ala 
            340                 345                 350         


Arg Lys Glu Ile Ile Glu Gly Glu Ile Ala Tyr Leu Gln Ser Lys Asp 
        355                 360                 365             


Val Phe Asn Lys Leu Val Pro Leu Trp Gln Leu His Leu Tyr Phe Thr 
    370                 375                 380                 


Lys Asn Gly His Pro Asp Phe Tyr Pro Asp Val Met Glu Tyr Leu Arg 
385                 390                 395                 400 


Asn Asn Ala Gly Asn Tyr Gly Gly Asn Asp Thr Val Lys Tyr Gln Phe 
                405                 410                 415     


Glu Phe Val Lys Ala Cys Cys Asp Val Thr Lys Thr Asp Leu Thr Asp 
            420                 425                 430         


Phe Phe Glu Lys Trp Gly Phe Phe Lys Pro Gly Lys Phe His Ile Gly 
        435                 440                 445             


Asp Tyr Ala Gln Tyr Asp Phe Asn Val Thr Pro Glu Met Val Glu Glu 
    450                 455                 460                 


Thr Lys Lys Trp Ile Ala Gly Lys Gly Tyr Pro Lys Pro Glu Thr Asp 
465                 470                 475                 480 


Ile Thr Glu Leu Ser Glu 
                485     


<210>  21
<211>  720
<212>  PRT
<213>  Akkermansia muciniphila

<400>  21

Lys Tyr Pro Ser Leu Asp Val Pro Glu Asp Ile Leu Leu His Val Lys 
1               5                   10                  15      


Glu Ala Ala Ser Ser Gln Ser Pro Tyr Ser Gly Asn His Ser Val Lys 
            20                  25                  30          


Gln Ala Val Asp Gly Ser Met Glu Ser Ala Asn Trp His Val Pro Gly 
        35                  40                  45              


Val His His Val Glu Gly Glu Phe Val Phe Glu Val Pro Glu Thr Ile 
    50                  55                  60                  


His Tyr Ile Ile Phe Ser Gly Ala Asn Phe Asn Glu Ile Ala Val Ser 
65                  70                  75                  80  


Ala Met Ser Gly Ser Ser Trp Lys Asp Leu Gly Lys Phe Asp Ile Gly 
                85                  90                  95      


Gly Ser Arg Met Ile Arg Phe Lys Lys Pro Leu Gln Lys Val Arg Lys 
            100                 105                 110         


Ile Arg Leu Thr Val Asp Tyr Pro Glu Gly Ser Ser Pro Ser Phe Thr 
        115                 120                 125             


Val Arg Glu Ile Ser Phe Tyr Lys Arg Val Glu Ser Ala Leu Asn Arg 
    130                 135                 140                 


Lys Leu Leu Lys Val Phe Lys Asp Thr Ser Cys Ser Ser Ile Asn Pro 
145                 150                 155                 160 


Arg Cys Thr Leu Thr Asp Leu Lys Ala Leu Pro Glu Phe Leu Gln Met 
                165                 170                 175     


Ile Ala Lys Lys Ile Lys Ser Gly Asp Tyr Glu Asp Lys Glu Phe Arg 
            180                 185                 190         


Ile Ala Ser Tyr Lys Ala Tyr Ser His Pro Glu Phe Ala Ala Lys Val 
        195                 200                 205             


Arg Asn Ile Asn Ala Leu Asn Lys Phe Asp Asn Pro Thr Gly Ile Val 
    210                 215                 220                 


Ala Glu Lys Gly Asp Glu Ile Leu Val Phe Val Gly Pro Thr His Gly 
225                 230                 235                 240 


Glu Asp Ile Gly Leu Ala Ser Val Ser Pro Ala Gly Ile Glu Ser Ser 
                245                 250                 255     


Ser Tyr Pro Leu Asn Glu Gly Val Asn Lys Ile Arg Ile Asn Arg Ser 
            260                 265                 270         


Gly Leu Leu Tyr Val Met Tyr His Thr Asp Ile Ser Pro Pro Lys Lys 
        275                 280                 285             


Pro Ile Thr Val His Ile Pro Val Gly Ser Gly Ile Val Asn Gly Tyr 
    290                 295                 300                 


Phe Asp Val Thr Arg His Thr Asp Lys Asp Trp Lys Arg Met Ile Ser 
305                 310                 315                 320 


Asn Ala Pro His Ser Met Phe Asp Ile Val Gly Arg Asn Ser Met Met 
                325                 330                 335     


Ile Leu His Thr Lys Tyr Leu Lys Asp Tyr Ser Pro Asp Ser Ile Thr 
            340                 345                 350         


Lys Ser Val Arg Val Trp Asp Glu Ser Val Lys Ala Met Trp Lys Ile 
        355                 360                 365             


Met Gly Phe Asp Lys Tyr Pro Gln Pro His Asn Asn Arg Gln Leu Gly 
    370                 375                 380                 


Val Ser Val Glu Gly Gly Ala His Met Phe Ala Thr Trp Tyr Tyr Cys 
385                 390                 395                 400 


Gly Tyr Ser Ile Gly Asp Gln Gly Asn Thr Leu Lys Asn Glu Val Leu 
                405                 410                 415     


Ala Pro Gly Val Leu Gln Gly Asn Arg Leu Trp Gly Ile Gly His Glu 
            420                 425                 430         


Ile Gly His Cys Tyr Gln His Pro Phe Asn Trp Arg Ser Met Ser Glu 
        435                 440                 445             


Ser Ser Asn Asn Phe Phe Ala Gln Leu Ile Leu Asp Gln Val Thr Asn 
    450                 455                 460                 


Ala Ile Asn Gly Asn Glu Gln Ala Ser Asp Met Glu Asn Pro Cys Lys 
465                 470                 475                 480 


Tyr Leu Leu Ser Glu Ala Val Lys Gly Met Pro Phe His Asp Leu Asn 
                485                 490                 495     


Gly Trp Ala Lys Trp Gly Phe Ala Gln Tyr Ser Phe Tyr Leu Tyr Phe 
            500                 505                 510         


His Lys Leu Gly Ile Asn Pro Glu Phe Tyr Pro Arg Leu Phe Glu Ser 
        515                 520                 525             


Leu Arg Arg Lys Pro Leu Ser Arg Gln Ala Tyr Glu Val Ser Glu Ala 
    530                 535                 540                 


His Leu Ala Leu Tyr Glu Arg Ile Cys Asn Ile Ser Arg Thr Asp Phe 
545                 550                 555                 560 


Thr Asp Asp Phe Glu Ile Phe Asn Trp Phe Val Pro Ile Asp Arg Lys 
                565                 570                 575     


Gly His Gln Tyr Gly Asp Tyr Ser Phe Lys Met Thr Glu Glu Met Ala 
            580                 585                 590         


Arg Ala Ser Lys Ala Arg Ile Ala Ala Lys Arg Tyr Pro Lys Pro Lys 
        595                 600                 605             


Phe Arg Ile Ala Phe Leu His Gln His Gly Lys Thr Val Asn Leu Trp 
    610                 615                 620                 


Gly Gln Asn Leu His Gly Ser Gln Leu Asn Gly Tyr Trp Thr Lys Tyr 
625                 630                 635                 640 


Lys Gln Asn Ala Lys Leu Ser Pro Ser Val Ser Ala Ser Lys Lys Asp 
                645                 650                 655     


Asn Met Ile Ile Val Arg Asn Gly Glu Asn Ala Ala Ala Phe Cys Val 
            660                 665                 670         


Val Thr Asn Gly Lys Val Val Gly Tyr Tyr Asp Arg Gln Lys Phe Asp 
        675                 680                 685             


Val Ser Gly Val Glu Trp Asn Asp Thr Ser Lys Val Tyr Ala Ile Pro 
    690                 695                 700                 


Ile Gln Thr Ala Glu Pro Tyr Lys Leu Ile Tyr Ala Ala Gly Arg Ser 
705                 710                 715                 720 


<210>  22
<211>  612
<212>  PRT
<213>  Akkermansia muciniphila

<400>  22

Gln Asp Asn Leu Ala Lys Arg Lys Ala Ala Gln Glu Leu Thr Ala Glu 
1               5                   10                  15      


Arg Lys Leu Lys Glu Lys Lys Ala Arg Glu Ala Ala Glu Lys Gln Arg 
            20                  25                  30          


Ile Lys Arg Glu Arg Glu Ile Arg Glu Lys Lys Glu Lys Glu Arg Leu 
        35                  40                  45              


Ala Ala Gln Lys Ala Tyr Glu Glu Ala Gln Glu Glu Lys Ala Arg Gln 
    50                  55                  60                  


Ala Ala Glu Ala Ala Arg Lys Leu Gln Glu Gln Ala Glu Arg Glu Glu 
65                  70                  75                  80  


Arg Glu Lys Arg Arg Arg Glu Glu Leu Glu Arg Arg Glu Arg Glu Glu 
                85                  90                  95      


Glu Ala Arg Arg Gln Glu Glu Asp Thr Pro Val Glu Glu Glu Pro Glu 
            100                 105                 110         


Pro Glu Gly Arg Phe Pro Gln Pro Val Lys Asn Arg Met Pro Glu Leu 
        115                 120                 125             


Ser Val Tyr Ser Ile Pro Cys Arg Asp Asp Ile Gln Thr Glu Lys Asp 
    130                 135                 140                 


Lys Leu Leu Glu Thr Trp Ser Trp Asp Lys Ala Glu Lys Met Glu Gly 
145                 150                 155                 160 


Met Glu Glu Phe Pro Thr Gly Ser Ser Pro Trp Lys Lys Gly Lys Asp 
                165                 170                 175     


Ala Gly Arg Met Gln Ala Leu Leu Glu Lys Cys Arg Glu Trp Lys Asp 
            180                 185                 190         


Ala Lys Leu Ala Ser Leu Lys Ala Cys Pro Ala Ala Lys Asp Phe Pro 
        195                 200                 205             


Gly Val Pro Glu Asn Gly Ala Gln Thr Val Arg Arg Thr Val Glu Ile 
    210                 215                 220                 


Asp Ser Asn Ile Gly Gly Trp His Ser Thr Gly Leu Tyr Ala Pro Pro 
225                 230                 235                 240 


Gly Ala Glu Ile Ser Cys Ser Leu Ser Gly Ala Pro Lys Asp Gly Ser 
                245                 250                 255     


Ile Ser Val Arg Ile Gly Cys His Thr Asp Ser Leu His Lys Leu Asp 
            260                 265                 270         


Glu Trp Lys Arg Val Pro Glu Ile Thr Met Gln Val Pro Ala Gly Arg 
        275                 280                 285             


Gly Arg Val Lys Met Val Asn Pro Met Gly Gly Leu Val Tyr Val Asn 
    290                 295                 300                 


Val Gly Gln Arg Pro Arg Arg Gly Lys Val Phe Lys Val Gln Ile Ser 
305                 310                 315                 320 


Gly Ala Val Pro Ser Pro Leu Phe Val Met Gly Lys Thr Thr Pro Glu 
                325                 330                 335     


Gln Trp Ala Glu Gln Leu Glu Asn Thr Lys Ala Pro Trp Gly Glu Ile 
            340                 345                 350         


Arg Met Pro Arg Leu Ile Val Thr Met Pro Val Glu Gln Leu Lys Gln 
        355                 360                 365             


Cys Pro Asp Val Gln Lys Thr Ala Glu Phe Leu Gln Lys Asn Met Ala 
    370                 375                 380                 


Leu Gln Asp Trp Ile Met Gly Trp Asp Thr Lys Pro Asp Arg Leu His 
385                 390                 395                 400 


His Pro Met Arg Phe Val Val Asp Arg Gln Ile Ser Ala Gly Ala Gly 
                405                 410                 415     


His Ser Gly Tyr Pro Ala Met Ala Thr Lys Asp Trp Thr Asn Ser Ile 
            420                 425                 430         


Ala Thr Gly Ser Ile Ile His Ser Gly Ser Trp Gly Leu Trp His Glu 
        435                 440                 445             


Leu Gly His Asn His Gln Ser Pro Pro Phe Thr Met Glu Gly Gln Thr 
    450                 455                 460                 


Glu Val Ser Val Asn Ile Phe Ser Met Val Cys Glu Val Met Gly Thr 
465                 470                 475                 480 


Gly Lys Asp Phe Glu Ser Cys Trp Gly Gly Gly Met Gly Pro Tyr Gly 
                485                 490                 495     


Met Ser Ala Glu Met Lys Lys Tyr Phe Ser Gly Thr Gln Thr Tyr Asn 
            500                 505                 510         


Glu Ala Pro Asn Lys Val Gln Leu Phe Phe Trp Val Glu Leu Met Tyr 
        515                 520                 525             


Tyr Leu Gly Phe Asp Ala Phe Arg Gln Val Ala Leu Gln Phe His Asp 
    530                 535                 540                 


Lys Pro Tyr Asp Asn Gly Glu Leu Ser Asp Glu Lys Lys Trp Glu Trp 
545                 550                 555                 560 


Val Met Asn Ala Phe Ser Lys Val Thr Gly Lys Asn Met Gly Pro Phe 
                565                 570                 575     


Phe Lys Ile Trp Arg Thr Pro Val Ser Glu Arg Ala Thr Gly Arg Met 
            580                 585                 590         


Lys Asp Leu Pro Ala Trp Leu Pro Ser Lys Asp Tyr Pro Ala Cys Tyr 
        595                 600                 605             


Thr Ala Glu Glu 
    610         


<210>  23
<211>  855
<212>  PRT
<213>  Serratia marcescens

<400>  23

Met Pro Thr Ile Thr Lys Thr Gln Ser Leu Tyr Thr Leu Thr Arg Pro 
1               5                   10                  15      


Val Trp Leu Asp Ala Ala Gly Met Ser Lys Gly Ile Asp His Asp Arg 
            20                  25                  30          


Gln His Leu Gly Ile Ile Leu Ala Ala Gly Gln Val Leu Arg Val Arg 
        35                  40                  45              


Gln Thr Asn Ala Ala Phe Thr Gly Lys Leu Thr Leu Arg Leu Leu Asn 
    50                  55                  60                  


Asp Asp Ser Lys Thr Glu Ala Glu Phe Ser Val Gly Ala Ser Trp Val 
65                  70                  75                  80  


Glu Ala Gln Val Asn Ala Val Ser Val Pro Phe Ile Asp Thr Pro Tyr 
                85                  90                  95      


Gly Gln Gly Glu Pro Ala Leu Glu Phe Glu Tyr Pro Asp Thr Ala Lys 
            100                 105                 110         


Ala Leu Pro Val Tyr Arg Arg Gly Glu Asn Glu Ala Ala Phe Phe Ala 
        115                 120                 125             


Arg Trp Asp Asp Arg Asp Ala Glu Phe Ala Leu Val Asp Ala Glu Tyr 
    130                 135                 140                 


Ala Val Leu Leu Val Pro Lys Ile Ser Lys Pro Ala Leu Lys Ser Leu 
145                 150                 155                 160 


Gly Glu Ala Lys Asn Ile Asp Gly Leu Ile Ala Tyr Tyr Asp Arg Ile 
                165                 170                 175     


Phe Thr Phe Tyr Asn Ala Leu Thr Gly Val Ser Phe Glu Ala Glu His 
            180                 185                 190         


Glu Ser Asp Arg Asn Ile Arg Asn Arg Tyr Phe Met Lys Ala Asp Lys 
        195                 200                 205             


His Gly Ala Gly Ala Ala Tyr Tyr Gly Gly Arg Trp Thr Ala Glu Thr 
    210                 215                 220                 


Ser Ser Ser Val Ser Ser Phe Trp Leu Thr Pro Lys Asp Ser Asn Trp 
225                 230                 235                 240 


Gly Ser Leu His Glu Ile Ala His Gly Tyr Gln Gly His Phe Met Gly 
                245                 250                 255     


Asp Lys Tyr Phe Ser Thr Gly Glu Met Trp Asn Asn Ile Tyr Ala Ala 
            260                 265                 270         


Cys Tyr Gln Asp Val Met Leu Gly Glu Arg Lys Tyr Gln Glu Gly Trp 
        275                 280                 285             


Leu Tyr Asn Tyr Gly Asn Ala Ala Gly Val Glu Lys Lys Ile Val Asp 
    290                 295                 300                 


Leu Ile Ala Gln Gly Thr Pro Leu Asn Gln Trp Asp Leu Arg Ser Lys 
305                 310                 315                 320 


Leu Phe Phe Ala Met Leu Met Val Asp Lys Ala Gly Lys Asn Ala Phe 
                325                 330                 335     


Thr His Phe Asn Gln Gln Tyr Arg Gln Ser Cys Asn Thr Pro Gly Phe 
            340                 345                 350         


Val Pro Ser Glu His Ala Leu Leu Asp Leu Leu Ser Ala Ser Phe Ala 
        355                 360                 365             


Ala Ala Gly Glu Gln Ile Asp Val Thr Pro Phe Val Glu Leu Thr Gly 
    370                 375                 380                 


Gly Val Ile Thr Gln Thr Gln Arg Asp Leu Asn Ala Phe Ser His Ala 
385                 390                 395                 400 


Lys Ala Val Tyr Pro Leu Tyr Gln Leu Val Asp Ala Gln Ser Leu Pro 
                405                 410                 415     


Ala Val Leu Ala Gln Leu Lys Leu Asp Ser Ser Leu Arg Leu Val Asp 
            420                 425                 430         


Ser Ser Gln Leu Lys Ala Ser Gly Leu Lys Gly Asp Val Ala Leu Ser 
        435                 440                 445             


Leu Asp Ile Asp Asp Phe Ala Gln Ile Tyr Gly Glu Asp Leu Val Leu 
    450                 455                 460                 


Met Glu Gly Ala Arg Tyr Ala His Lys Val Arg Ile Asp Ala Pro Thr 
465                 470                 475                 480 


Leu Ala Leu Asn Ala Leu Pro Ile Gly Val Tyr Thr Leu Arg Leu Pro 
                485                 490                 495     


Thr Gly Lys Asp Arg Lys Tyr Arg Pro Thr Ala Gly Tyr Leu Thr Val 
            500                 505                 510         


Lys Gln Gly Lys Ser Ala Val Thr Leu Arg Phe Glu Arg Lys Ala Ala 
        515                 520                 525             


Ser Pro Ile Val Ser Gln Glu Ile Asn Leu Leu Gly Leu Ser Asp Ala 
    530                 535                 540                 


Val Phe Ala Thr Val Val Val Asp Arg Ala Lys Gly Ala Val Val Val 
545                 550                 555                 560 


Asp Val Thr Ser Thr Thr Pro His Ala Tyr Phe Pro Gly Glu Thr Tyr 
                565                 570                 575     


Ala Arg Val Thr Leu Arg Asp Arg Gln Gly Ala Val Arg Phe Ser Lys 
            580                 585                 590         


Glu Val Gln Gly Thr Gln Ala Thr Leu Ser His Asp Glu Leu Pro Phe 
        595                 600                 605             


Ala Glu Gly Asp Asp Ile Glu Ile Tyr His Val Glu Pro Ser Arg Val 
    610                 615                 620                 


Arg Leu Asn Pro Ala Ala Ala Gly Val Ile Asp Asn Lys Asn Lys Thr 
625                 630                 635                 640 


Asn Val Leu Arg Ile Glu Thr Ser Gly Leu Lys Asn Pro Ala Leu Ser 
                645                 650                 655     


Gly Asp Pro Glu Gln Ala Leu Leu Met Arg Leu Glu Gln Ala Ala Gln 
            660                 665                 670         


Arg Leu Arg Arg Leu Leu Pro Ala Tyr Tyr Ala Pro Ser Ser Ser Phe 
        675                 680                 685             


Lys Asp Asp Ile Tyr Leu Ala Ile Gly Ala Phe Ala Glu Pro Gln Arg 
    690                 695                 700                 


Glu Pro Leu Leu Ala Thr Tyr Arg Asp Cys Leu Pro Ala Asp Asn Thr 
705                 710                 715                 720 


Pro Pro Gly Ala Asn Val Gly Asn Ala Phe Thr Val Ala Gly Lys Gly 
                725                 730                 735     


Ile Gly Asp Arg Gln Phe Leu Thr Cys Ala Val Asp Leu Val Lys Lys 
            740                 745                 750         


Thr Val Thr Val Thr Leu Ala Ala Gly Ile Ala His His Tyr Phe Ala 
        755                 760                 765             


Asp Ser Tyr Ala Phe Leu Ser Val Thr Asp Ala Asp Gly Asn Thr Leu 
    770                 775                 780                 


Leu Ser Tyr Asp Val Ile Gly Ser Gln Asn Gln Gln Ala Lys Thr Trp 
785                 790                 795                 800 


Val Leu Pro Leu Ser Gly Tyr Gly Gly Glu Val Ile His Leu Arg His 
                805                 810                 815     


Glu Glu Pro Asp Asn Arg Leu Thr Ile Val Asn Glu Met Gln His Val 
            820                 825                 830         


Arg Leu Ala Glu Lys Gly Lys Gln Gln Ala Tyr Cys Ile Thr Pro Val 
        835                 840                 845             


Gly Leu Lys Arg Ile Lys Asp 
    850                 855 


<210>  24
<211>  961
<212>  PRT
<213>  Vibrio harvevi

<400>  24

Gln Val Ile Gln Phe Asn Asn Glu Thr Pro Val Asn Asn Leu Gln Gly 
1               5                   10                  15      


Asp Phe Glu Ala Met Val Ile Tyr Ala Gln Asn Ile Thr Val Pro His 
            20                  25                  30          


Tyr Asn Asp Lys Gly Asp Pro Arg Pro His Leu Thr Ala Leu Arg Asp 
        35                  40                  45              


Thr Leu Leu Leu Val Lys Pro Val Glu Pro Leu Asn Val Ser Ser Gln 
    50                  55                  60                  


Val Lys Val Ile Ala Arg Asp Ser Gln Gly Asn Gln Leu Gly Ala Leu 
65                  70                  75                  80  


Ser Leu Asn Thr Pro Glu Gln Leu Pro Asn His Asp Gly Pro Asn Leu 
                85                  90                  95      


Asp Ile Met Tyr Ala Lys Asp Met Trp Ser Val Thr Leu Pro Ala Thr 
            100                 105                 110         


Trp Ile Gln Pro Gly Leu Thr Leu Glu Leu Leu Asn Gly Ser Thr Ser 
        115                 120                 125             


Gly Leu Leu Ser Asp Leu Asp Ile Gly Ala Pro Asn Glu Leu Leu Ile 
    130                 135                 140                 


Asn Thr Met Asp Leu Gly Met Leu Thr Asn Pro Arg Gly Arg Phe Tyr 
145                 150                 155                 160 


Phe Ala Asp Asn Pro Glu Leu His Lys Asp Tyr Phe Gln Lys Ile Pro 
                165                 170                 175     


Val Ser Lys Leu Ile Val Asn Pro Tyr Glu Thr Val Lys Leu Asp Glu 
            180                 185                 190         


Val Met Leu Pro Asp Gly Asp Leu Leu Thr Glu Leu Asp Pro Ser Thr 
        195                 200                 205             


Gly Thr Trp His Gln Gly Asp Met Arg Ala Asp Thr Thr Lys Ile Leu 
    210                 215                 220                 


Met Ser His Gly Ile Asn Leu Ala Asn Tyr Gly Ile Asn Ser Ser Thr 
225                 230                 235                 240 


Ser Val Ser Glu Arg Ala His Pro Tyr Thr Ala Asn Gln Ile Thr Ala 
                245                 250                 255     


Ile Ala Ala Val Gly Arg Tyr Gln Asn Gly Val Val Ala His Gly Gly 
            260                 265                 270         


Ser Gly Gly Asn Gly Met Val Thr Ile Asp Ser Ser Val Gly Asn Glu 
        275                 280                 285             


Trp Ser His Glu Val Gly His Asn Phe Gly Leu Gly His Trp Pro Gly 
    290                 295                 300                 


Gly Thr Asp Gly Thr Thr His Arg Pro Ser Thr Asp Ile Asn Ser Ala 
305                 310                 315                 320 


Trp Gly Trp Asp Leu Phe Gln Lys Arg Phe Ile Ala Asn Phe Met Trp 
                325                 330                 335     


Asn Lys Arg Asn Gly Glu Asp Gln Val Cys Cys Ser Asp Gly Ile Gly 
            340                 345                 350         


Ile Pro Ala Phe Glu Gly Tyr Lys Phe Asn Arg Asp Ala Met Gly Gly 
        355                 360                 365             


Gly Glu Pro Thr Ser Pro Ile Ser Lys Tyr Thr Leu His Thr Pro Tyr 
    370                 375                 380                 


Val Leu Glu Lys Ile Gln Thr Phe Met Glu Gly Lys Ala Thr Phe Asp 
385                 390                 395                 400 


Glu Ser Ser Pro Thr Gly Phe Thr Lys Trp Asn Asp Glu Thr Lys Ala 
                405                 410                 415     


Met Gln Ala Phe Gln Gln Pro Ala Ile Leu Leu Ser Lys Ser Ile Thr 
            420                 425                 430         


Ser Gln Ser Gln Leu Asn Thr Ile Lys Asp Asp Ile Asp Gly Ser Val 
        435                 440                 445             


Leu Leu Gly Tyr Ile Asn Asp Phe Asp Ile Thr Lys Val Glu Thr Gly 
    450                 455                 460                 


Asp Gly Arg Trp Ile Arg Asp Ile Tyr Leu Pro Ser Ala Glu Asn Val 
465                 470                 475                 480 


Ala Val Gly Lys Ala Val Asn Ile Ala Arg Tyr Ser Gly Tyr Gly Val 
                485                 490                 495     


Thr Ala His Val Asn Gly Gln Leu Val Asn Leu Asn Arg Gly Asp Ser 
            500                 505                 510         


Lys Phe Tyr Ile Ser Asp Gly Lys Ala Trp Leu Glu Thr Thr Glu Asp 
        515                 520                 525             


Gln Val Ala Glu Gly Lys Pro Thr Arg Ile Pro Thr Asp Tyr Gly Val 
    530                 535                 540                 


Pro Val Thr Thr Leu Val Gly Tyr Tyr Asp Pro Gln Gln Gln Leu Asp 
545                 550                 555                 560 


Ser Tyr Ile Phe Pro Ala Leu His Gly Ala Tyr Gly Phe Val Tyr Gln 
                565                 570                 575     


Pro Thr Pro Val Asp Arg Leu Asp Thr Thr Gly Cys Tyr Val Lys Val 
            580                 585                 590         


Tyr Asn Gly Gln Asp His Gln Thr Asp Asn Tyr Gln Leu Val Gly Phe 
        595                 600                 605             


Arg Phe Asp Asp Asn Val Met Asn Lys Phe His Ile Asn Leu Lys Gln 
    610                 615                 620                 


Thr Asp Asp Pro Thr Arg Ala Glu Val Val Cys Asp Asn Ala Val Leu 
625                 630                 635                 640 


Ser Ser Leu Asp Ile Glu Lys Pro Lys Gln Ala Leu Glu Val Ser Ile 
                645                 650                 655     


Val Gln Ser Asp Ser Leu Lys Pro Ser Glu Asn Asn Lys Pro Val Ala 
            660                 665                 670         


His Ala Gly Glu Asp Gln Ser Val Leu Ser Gly Ala Thr Ile Thr Leu 
        675                 680                 685             


Ser Ala Asp Lys Ser Thr Asp Ala Asp Gly Asp Lys Leu Thr Tyr Val 
    690                 695                 700                 


Trp Glu Gln Ile Ser Gly Leu Pro Ala Ser Ile Gln Ala Ser Asn Ala 
705                 710                 715                 720 


Met Thr Thr Asn Val Val Leu Ala Glu Ser Thr Gln Glu Gln Ser Tyr 
                725                 730                 735     


Val Phe Ser Val Leu Val Ser Asp Gly Lys Ser Ser Ser Ser Asp Met 
            740                 745                 750         


Val Thr Ile Ile Ala Gln Pro Gln Pro Thr Gln Asn His Ala Pro Glu 
        755                 760                 765             


Val Ser Leu Pro Ser Ser Ile Asp Ala Lys Pro Gly Glu Val Ile Glu 
    770                 775                 780                 


Ile Thr Ala Thr Ala Ser Asp Pro Asp Gly Asp Val Leu Ser Phe Lys 
785                 790                 795                 800 


Trp Ser Thr Ser Gly Leu Ala Tyr Gln Thr Met Ser Gly Gly Thr Ile 
                805                 810                 815     


Gln Leu Ser Val Pro Asp Val Thr Val Asp Ser Gln Phe Leu Leu Ser 
            820                 825                 830         


Val Val Val Ser Asp Pro Lys Gly Glu Ser Ala Ser Ala Asn Thr Thr 
        835                 840                 845             


Leu Asn Val Lys Ala Ser Gly Asn Thr Cys Ser Val Ser Asp Pro Asn 
    850                 855                 860                 


Ala Thr Asn Tyr Asp Ala Trp Ser Ala Ser Lys Ser Tyr Ser Gly Gly 
865                 870                 875                 880 


Asp Leu Val Ser Tyr Lys Gln Leu Val Trp Lys Ala Lys His Trp Ser 
                885                 890                 895     


Gln Asn Asn Gln Pro Asp Ser Ser Asp Ala Trp Glu Leu Leu Ser Asp 
            900                 905                 910         


Val Val Leu Pro Trp Ser Ser Gln Ala Ala Tyr Ser Gly Gly Ala Gln 
        915                 920                 925             


Val Thr Tyr Asn Gly Val Lys Phe Glu Ala Lys Trp Trp Thr Arg Gly 
    930                 935                 940                 


Glu Gln Pro Asn Val Ser Ser Val Trp Ile Asn Lys Gly Ala Ala Cys 
945                 950                 955                 960 


Gln 
    


<210>  25
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  The amino acid at position 1 can be Ser or Thr

<220>
<221>  CARBOHYD
<222>  (1)..(1)

<220>
<221>  VARIANT
<222>  (2)..(5)
<223>  The amino acids at positions 2 to 5 can be any amino acid

<400>  25

Xaa Xaa Xaa Xaa Xaa 
1               5   


