                         SEQUENCE LISTING

<110>  The University of North Carolina at Chapel Hill
       Gray, Steven James
       Bailey, Rachel
 
<120>  Optimized FIG4 Genes and Expression Cassettes and Their Use

<130>  5470-854WO

<150>  US 62/755,871
<151>  2018-11-05

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  2721
<212>  DNA
<213>  Artificial

<220>
<223>  Human codon-optimized FIG4 open reading frame

<400>  1
atgccaactg ccgccgcccc aatcatttca tcagtgcaaa agcttgtgct ctacgagaca       60

agagctcggt atttcctggt cggctccaac aacgcagaaa ccaagtacag agtgcttaag      120

attgaccgca ccgaaccgaa ggacctcgtg attattgacg atcgccacgt gtacactcag      180

caagaagtgc gcgaactctt gggacgcctg gacctgggca accgaaccaa aatgggccag      240

aagggctcct ccggtctgtt tcgggcagtg tcggctttcg gcgtcgtggg attcgtgcga      300

ttccttgagg ggtactatat tgtgctgatc acgaagcggc gcaagatggc cgacatcgga      360

ggacacgcta tatacaaggt cgaggacacc aacatgatct acattccgaa cgattcagtc      420

agagtgaccc accccgatga agcccgctac cttagaatct tccagaacgt ggatctctcc      480

tcgaactttt acttctcata ctcgtacgac ctgtcccact cgctgcagta caacctgacc      540

gtgctgcgga tgcctctgga gatgctcaag tccgagatga ctcaaaatcg gcaggaatcc      600

ttcgacatct tcgaggacga gggtctgatc actcaaggag ggtcgggagt gttcggcatt      660

tgcagcgaac cctacatgaa atacgtgtgg aacggagagc tcctggacat tatcaagagc      720

actgtgcacc gggactggct gctgtacatc atccatggat tctgtggaca gtcaaagctc      780

ctgatctatg gccggcctgt gtacgtgact ctgatcgccc gccgctcctc gaagttcgcg      840

ggtacccggt ttctcaagcg cggtgctaac tgcgaggggg atgtggccaa cgaagtggaa      900

accgagcaga tcctctgtga cgcctccgtg atgagcttta ccgccggatc ctactcttcg      960

tatgtgcaag tccggggatc cgtccccctg tactggagcc aggacatctc cactatgatg     1020

cccaagcccc ctatcaccct ggaccaggcc gatcctttcg cacacgtggc tgccctgcac     1080

ttcgaccaga tgttccagcg gttcggctcc cctatcatca tcctgaactt ggtcaaggaa     1140

cgggagaagc ggaagcatga gaggattctg tccgaggagc tcgtggccgc ggtgacctac     1200

ctgaatcagt tcctcccgcc cgaacatacc atcgtgtata tcccctggga tatggccaag     1260

tacactaagt ccaagctgtg caatgtgctg gaccgcctta acgtcatcgc ggaatccgtg     1320

gtcaagaaaa ccggattctt cgtgaataga ccggattcat actgctccat tctccggccc     1380

gatgaaaagt ggaacgaact gggcggttgc gtcatcccga ctggccggct ccagaccggc     1440

atccttagga ccaactgcgt ggactgcctg gacagaacca acacggccca attcatggtc     1500

gggaaatgtg ccctggccta ccaactgtac tccctgggac tgatcgacaa gccgaacttg     1560

caattcgata ctgacgccgt gcggctgttc gaagaactgt acgaggatca cggcgacacc     1620

ctgagcctgc agtacggcgg aagccagctc gtgcatagag tgaaaaccta caggaagatt     1680

gctccgtgga ctcagcactc gaaggacatc atgcagaccc tcagccgcta ctactccaat     1740

gccttctccg acgccgaccg ccaggactcc attaacctct tcctgggagt gttccaccca     1800

accgagggaa agccccacct gtgggaactg cctactgatt tctacttgca tcacaagaac     1860

accatgagac tcctgcccac ccggcgctcc tacacttact ggtggacccc tgaagtgatc     1920

aagcacctcc cgctgccgta cgacgaggtc atctgcgccg tgaacctgaa aaagctgatc     1980

gtcaaaaagt tccataaata tgaagaagaa atcgacattc acaacgaatt cttccggcca     2040

tacgagctgt cctcgttcga cgacaccttt tgtctggcga tgacctcatc cgcccgcgat     2100

ttcatgccta agactgtggg gatcgacccc agccccttca ccgtccgcaa gcctgacgag     2160

actggaaagt cggtgctcgg caacaagagc aacagggaag aagcggtgct tcagagaaag     2220

actgctgcct cggcgccacc gccgccttcc gaagaagccg tgtcgtcatc ctcggaagat     2280

gacagcggaa ccgaccgcga ggaggagggg tccgtgagcc agcggtccac cccggtcaag     2340

atgactgacg ccggggactc ggccaaggtc accgaaaacg tggtgcaacc catgaaggaa     2400

ctgtacggca tcaaccttag cgacggcttg tctgaagagg acttctccat ctactctcgg     2460

tttgtgcagc tggggcagag ccagcacaag caggacaaga attcccaaca gccgtgcagc     2520

agatgctccg acggagtgat taagctgact ccgattagcg cgttctcgca agataacatc     2580

tacgaagtgc aaccccctcg cgtggacagg aagtccaccg agattttcca ggcccacatc     2640

caagcatccc agggaatcat gcagcccctc gggaaagagg actcctccat gtaccgggag     2700

tacatcagaa accgctacct g                                               2721


<210>  2
<211>  306
<212>  DNA
<213>  Artificial

<220>
<223>  Chicken beta-actin promoter

<400>  2
tacgtattag tcatcgctat taccatggtc gaggtgagcc ccacgttctg cttcactctc       60

cccatctccc ccccctcccc acccccaatt ttgtatttat ttatttttta attattttgt      120

gcagcgatgg gggcgggggg gggggggggg cgcgcgccag gcggggcggg gcggggcgag      180

gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg cgcgctccga      240

aagtttcctt ttatggcgag gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg      300

cgggcg                                                                 306


<210>  3
<211>  1068
<212>  DNA
<213>  Artificial

<220>
<223>  Chicken beta-actin exon 1 and intron

<400>  3
ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc       60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      180

aagccttgag gggctccggg agggcccttt gtgcgggggg gagcggctcg gggggtgcgt      240

gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggcccgcg ctgcccggcg gctgtgagcg      300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg      360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt      420

gtgcgtgggg gggtgagcag ggggtatggg cgcggcggtc gggctgtaac ccccccctgc      480

acccccctcc ccgagttgct gagcacggcc cggcttcggg tgcggggctc cgtacggggc      540

gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg      600

cggggccgcc tcgggccggg gagggctcgg gggaggggcg cggcggcccc cggagcgccg      660

gcggctgtcg aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg      720

cgcagggact tcctttgtcc caaatctgtg cggagccgaa atctgggagg cgccgccgca      780

ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg      840

agggccttcg tgcgtcgccg cgccgccgtc cccttctccc tctccagcct cggggctgtc      900

cgcgggggga cggctgcctt cgggggggac ggggcagggc ggggttcggc ttctggcgtg      960

tgaccggcgg ctctagagcc tctgctaacc atgttcatgc cttcttcttt ttcctacagc     1020

tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt tggcaaag                  1068


<210>  4
<211>  239
<212>  DNA
<213>  Artificial

<220>
<223>  Cytomegalovirus enhancer

<400>  4
tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaatag taacgccaat       60

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt      120

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc      180

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatct       239


<210>  5
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic polyadenylation signal (SpA)

<400>  5
aataaagagc tcagatgcat cgatcagagt gtgttggttt tttgtgtg                    48


<210>  6
<211>  4800
<212>  DNA
<213>  Artificial

<220>
<223>  FIG4 expression cassette

<400>  6
gggggggggg gggggggttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg       60

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag      120

cgcgcagaga gggagtggcc aactccatca ctaggggttc ctagatctga attcggtacc      180

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      240

gacgtcaata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg      300

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      360

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt      420

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc      480

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt      540

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg      600

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg aaaggtgcgg cggcagccaa      660

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta      720

taaaaagcga agcgcgcggc gggcgggagt cgctgcgacg ctgccttcgc cccgtgcccc      780

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      840

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      900

ttgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg      960

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1020

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1080

gtgtgcgcga ggggagcgcg gccgggggcg gtgccccgcg gtgcgggggg ggctgcgagg     1140

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tgggggggtg agcagggggt atgggcgcgg     1200

cggtcgggct gtaacccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1260

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1320

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1380

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1440

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1500

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1560

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1620

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1680

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1740

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1800

cattttggca aagaccggtt ccggacgcca ccatgccaac tgccgccgcc ccaatcattt     1860

catcagtgca aaagcttgtg ctctacgaga caagagctcg gtatttcctg gtcggctcca     1920

acaacgcaga aaccaagtac agagtgctta agattgaccg caccgaaccg aaggacctcg     1980

tgattattga cgatcgccac gtgtacactc agcaagaagt gcgcgaactc ttgggacgcc     2040

tggacctggg caaccgaacc aaaatgggcc agaagggctc ctccggtctg tttcgggcag     2100

tgtcggcttt cggcgtcgtg ggattcgtgc gattccttga ggggtactat attgtgctga     2160

tcacgaagcg gcgcaagatg gccgacatcg gaggacacgc tatatacaag gtcgaggaca     2220

ccaacatgat ctacattccg aacgattcag tcagagtgac ccaccccgat gaagcccgct     2280

accttagaat cttccagaac gtggatctct cctcgaactt ttacttctca tactcgtacg     2340

acctgtccca ctcgctgcag tacaacctga ccgtgctgcg gatgcctctg gagatgctca     2400

agtccgagat gactcaaaat cggcaggaat ccttcgacat cttcgaggac gagggtctga     2460

tcactcaagg agggtcggga gtgttcggca tttgcagcga accctacatg aaatacgtgt     2520

ggaacggaga gctcctggac attatcaaga gcactgtgca ccgggactgg ctgctgtaca     2580

tcatccatgg attctgtgga cagtcaaagc tcctgatcta tggccggcct gtgtacgtga     2640

ctctgatcgc ccgccgctcc tcgaagttcg cgggtacccg gtttctcaag cgcggtgcta     2700

actgcgaggg ggatgtggcc aacgaagtgg aaaccgagca gatcctctgt gacgcctccg     2760

tgatgagctt taccgccgga tcctactctt cgtatgtgca agtccgggga tccgtccccc     2820

tgtactggag ccaggacatc tccactatga tgcccaagcc ccctatcacc ctggaccagg     2880

ccgatccttt cgcacacgtg gctgccctgc acttcgacca gatgttccag cggttcggct     2940

cccctatcat catcctgaac ttggtcaagg aacgggagaa gcggaagcat gagaggattc     3000

tgtccgagga gctcgtggcc gcggtgacct acctgaatca gttcctcccg cccgaacata     3060

ccatcgtgta tatcccctgg gatatggcca agtacactaa gtccaagctg tgcaatgtgc     3120

tggaccgcct taacgtcatc gcggaatccg tggtcaagaa aaccggattc ttcgtgaata     3180

gaccggattc atactgctcc attctccggc ccgatgaaaa gtggaacgaa ctgggcggtt     3240

gcgtcatccc gactggccgg ctccagaccg gcatccttag gaccaactgc gtggactgcc     3300

tggacagaac caacacggcc caattcatgg tcgggaaatg tgccctggcc taccaactgt     3360

actccctggg actgatcgac aagccgaact tgcaattcga tactgacgcc gtgcggctgt     3420

tcgaagaact gtacgaggat cacggcgaca ccctgagcct gcagtacggc ggaagccagc     3480

tcgtgcatag agtgaaaacc tacaggaaga ttgctccgtg gactcagcac tcgaaggaca     3540

tcatgcagac cctcagccgc tactactcca atgccttctc cgacgccgac cgccaggact     3600

ccattaacct cttcctggga gtgttccacc caaccgaggg aaagccccac ctgtgggaac     3660

tgcctactga tttctacttg catcacaaga acaccatgag actcctgccc acccggcgct     3720

cctacactta ctggtggacc cctgaagtga tcaagcacct cccgctgccg tacgacgagg     3780

tcatctgcgc cgtgaacctg aaaaagctga tcgtcaaaaa gttccataaa tatgaagaag     3840

aaatcgacat tcacaacgaa ttcttccggc catacgagct gtcctcgttc gacgacacct     3900

tttgtctggc gatgacctca tccgcccgcg atttcatgcc taagactgtg gggatcgacc     3960

ccagcccctt caccgtccgc aagcctgacg agactggaaa gtcggtgctc ggcaacaaga     4020

gcaacaggga agaagcggtg cttcagagaa agactgctgc ctcggcgcca ccgccgcctt     4080

ccgaagaagc cgtgtcgtca tcctcggaag atgacagcgg aaccgaccgc gaggaggagg     4140

ggtccgtgag ccagcggtcc accccggtca agatgactga cgccggggac tcggccaagg     4200

tcaccgaaaa cgtggtgcaa cccatgaagg aactgtacgg catcaacctt agcgacggct     4260

tgtctgaaga ggacttctcc atctactctc ggtttgtgca gctggggcag agccagcaca     4320

agcaggacaa gaattcccaa cagccgtgca gcagatgctc cgacggagtg attaagctga     4380

ctccgattag cgcgttctcg caagataaca tctacgaagt gcaaccccct cgcgtggaca     4440

ggaagtccac cgagattttc caggcccaca tccaagcatc ccagggaatc atgcagcccc     4500

tcgggaaaga ggactcctcc atgtaccggg agtacatcag aaaccgctac ctgtagtaac     4560

tcgagaataa agagctcaga tgcatcgatc agagtgtgtt ggttttttgt gtgacgcgtg     4620

catgctgggg agagatctag gaacccctag tgatggagtt ggccactccc tctctgcgcg     4680

ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc     4740

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caaccccccc cccccccccc     4800


<210>  7
<211>  907
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Optimized hFIG4

<400>  7

Met Pro Thr Ala Ala Ala Pro Ile Ile Ser Ser Val Gln Lys Leu Val 
1               5                   10                  15      


Leu Tyr Glu Thr Arg Ala Arg Tyr Phe Leu Val Gly Ser Asn Asn Ala 
            20                  25                  30          


Glu Thr Lys Tyr Arg Val Leu Lys Ile Asp Arg Thr Glu Pro Lys Asp 
        35                  40                  45              


Leu Val Ile Ile Asp Asp Arg His Val Tyr Thr Gln Gln Glu Val Arg 
    50                  55                  60                  


Glu Leu Leu Gly Arg Leu Asp Leu Gly Asn Arg Thr Lys Met Gly Gln 
65                  70                  75                  80  


Lys Gly Ser Ser Gly Leu Phe Arg Ala Val Ser Ala Phe Gly Val Val 
                85                  90                  95      


Gly Phe Val Arg Phe Leu Glu Gly Tyr Tyr Ile Val Leu Ile Thr Lys 
            100                 105                 110         


Arg Arg Lys Met Ala Asp Ile Gly Gly His Ala Ile Tyr Lys Val Glu 
        115                 120                 125             


Asp Thr Asn Met Ile Tyr Ile Pro Asn Asp Ser Val Arg Val Thr His 
    130                 135                 140                 


Pro Asp Glu Ala Arg Tyr Leu Arg Ile Phe Gln Asn Val Asp Leu Ser 
145                 150                 155                 160 


Ser Asn Phe Tyr Phe Ser Tyr Ser Tyr Asp Leu Ser His Ser Leu Gln 
                165                 170                 175     


Tyr Asn Leu Thr Val Leu Arg Met Pro Leu Glu Met Leu Lys Ser Glu 
            180                 185                 190         


Met Thr Gln Asn Arg Gln Glu Ser Phe Asp Ile Phe Glu Asp Glu Gly 
        195                 200                 205             


Leu Ile Thr Gln Gly Gly Ser Gly Val Phe Gly Ile Cys Ser Glu Pro 
    210                 215                 220                 


Tyr Met Lys Tyr Val Trp Asn Gly Glu Leu Leu Asp Ile Ile Lys Ser 
225                 230                 235                 240 


Thr Val His Arg Asp Trp Leu Leu Tyr Ile Ile His Gly Phe Cys Gly 
                245                 250                 255     


Gln Ser Lys Leu Leu Ile Tyr Gly Arg Pro Val Tyr Val Thr Leu Ile 
            260                 265                 270         


Ala Arg Arg Ser Ser Lys Phe Ala Gly Thr Arg Phe Leu Lys Arg Gly 
        275                 280                 285             


Ala Asn Cys Glu Gly Asp Val Ala Asn Glu Val Glu Thr Glu Gln Ile 
    290                 295                 300                 


Leu Cys Asp Ala Ser Val Met Ser Phe Thr Ala Gly Ser Tyr Ser Ser 
305                 310                 315                 320 


Tyr Val Gln Val Arg Gly Ser Val Pro Leu Tyr Trp Ser Gln Asp Ile 
                325                 330                 335     


Ser Thr Met Met Pro Lys Pro Pro Ile Thr Leu Asp Gln Ala Asp Pro 
            340                 345                 350         


Phe Ala His Val Ala Ala Leu His Phe Asp Gln Met Phe Gln Arg Phe 
        355                 360                 365             


Gly Ser Pro Ile Ile Ile Leu Asn Leu Val Lys Glu Arg Glu Lys Arg 
    370                 375                 380                 


Lys His Glu Arg Ile Leu Ser Glu Glu Leu Val Ala Ala Val Thr Tyr 
385                 390                 395                 400 


Leu Asn Gln Phe Leu Pro Pro Glu His Thr Ile Val Tyr Ile Pro Trp 
                405                 410                 415     


Asp Met Ala Lys Tyr Thr Lys Ser Lys Leu Cys Asn Val Leu Asp Arg 
            420                 425                 430         


Leu Asn Val Ile Ala Glu Ser Val Val Lys Lys Thr Gly Phe Phe Val 
        435                 440                 445             


Asn Arg Pro Asp Ser Tyr Cys Ser Ile Leu Arg Pro Asp Glu Lys Trp 
    450                 455                 460                 


Asn Glu Leu Gly Gly Cys Val Ile Pro Thr Gly Arg Leu Gln Thr Gly 
465                 470                 475                 480 


Ile Leu Arg Thr Asn Cys Val Asp Cys Leu Asp Arg Thr Asn Thr Ala 
                485                 490                 495     


Gln Phe Met Val Gly Lys Cys Ala Leu Ala Tyr Gln Leu Tyr Ser Leu 
            500                 505                 510         


Gly Leu Ile Asp Lys Pro Asn Leu Gln Phe Asp Thr Asp Ala Val Arg 
        515                 520                 525             


Leu Phe Glu Glu Leu Tyr Glu Asp His Gly Asp Thr Leu Ser Leu Gln 
    530                 535                 540                 


Tyr Gly Gly Ser Gln Leu Val His Arg Val Lys Thr Tyr Arg Lys Ile 
545                 550                 555                 560 


Ala Pro Trp Thr Gln His Ser Lys Asp Ile Met Gln Thr Leu Ser Arg 
                565                 570                 575     


Tyr Tyr Ser Asn Ala Phe Ser Asp Ala Asp Arg Gln Asp Ser Ile Asn 
            580                 585                 590         


Leu Phe Leu Gly Val Phe His Pro Thr Glu Gly Lys Pro His Leu Trp 
        595                 600                 605             


Glu Leu Pro Thr Asp Phe Tyr Leu His His Lys Asn Thr Met Arg Leu 
    610                 615                 620                 


Leu Pro Thr Arg Arg Ser Tyr Thr Tyr Trp Trp Thr Pro Glu Val Ile 
625                 630                 635                 640 


Lys His Leu Pro Leu Pro Tyr Asp Glu Val Ile Cys Ala Val Asn Leu 
                645                 650                 655     


Lys Lys Leu Ile Val Lys Lys Phe His Lys Tyr Glu Glu Glu Ile Asp 
            660                 665                 670         


Ile His Asn Glu Phe Phe Arg Pro Tyr Glu Leu Ser Ser Phe Asp Asp 
        675                 680                 685             


Thr Phe Cys Leu Ala Met Thr Ser Ser Ala Arg Asp Phe Met Pro Lys 
    690                 695                 700                 


Thr Val Gly Ile Asp Pro Ser Pro Phe Thr Val Arg Lys Pro Asp Glu 
705                 710                 715                 720 


Thr Gly Lys Ser Val Leu Gly Asn Lys Ser Asn Arg Glu Glu Ala Val 
                725                 730                 735     


Leu Gln Arg Lys Thr Ala Ala Ser Ala Pro Pro Pro Pro Ser Glu Glu 
            740                 745                 750         


Ala Val Ser Ser Ser Ser Glu Asp Asp Ser Gly Thr Asp Arg Glu Glu 
        755                 760                 765             


Glu Gly Ser Val Ser Gln Arg Ser Thr Pro Val Lys Met Thr Asp Ala 
    770                 775                 780                 


Gly Asp Ser Ala Lys Val Thr Glu Asn Val Val Gln Pro Met Lys Glu 
785                 790                 795                 800 


Leu Tyr Gly Ile Asn Leu Ser Asp Gly Leu Ser Glu Glu Asp Phe Ser 
                805                 810                 815     


Ile Tyr Ser Arg Phe Val Gln Leu Gly Gln Ser Gln His Lys Gln Asp 
            820                 825                 830         


Lys Asn Ser Gln Gln Pro Cys Ser Arg Cys Ser Asp Gly Val Ile Lys 
        835                 840                 845             


Leu Thr Pro Ile Ser Ala Phe Ser Gln Asp Asn Ile Tyr Glu Val Gln 
    850                 855                 860                 


Pro Pro Arg Val Asp Arg Lys Ser Thr Glu Ile Phe Gln Ala His Ile 
865                 870                 875                 880 


Gln Ala Ser Gln Gly Ile Met Gln Pro Leu Gly Lys Glu Asp Ser Ser 
                885                 890                 895     


Met Tyr Arg Glu Tyr Ile Arg Asn Arg Tyr Leu 
            900                 905         


<210>  8
<211>  907
<212>  PRT
<213>  Macaca mulatta

<400>  8

Met Pro Ser Ala Ala Ala Pro Ile Ile Ser Ser Val Gln Lys Leu Val 
1               5                   10                  15      


Leu Tyr Glu Thr Arg Ala Arg Tyr Phe Leu Val Gly Ser Asn Asn Ala 
            20                  25                  30          


Glu Thr Lys Tyr Arg Val Leu Lys Ile Asp Arg Thr Glu Pro Lys Asp 
        35                  40                  45              


Leu Val Ile Ile Asp Asp Arg His Val Tyr Thr Gln Gln Glu Val Arg 
    50                  55                  60                  


Glu Leu Leu Gly Arg Leu Asp Leu Gly Asn Arg Thr Lys Met Gly Gln 
65                  70                  75                  80  


Lys Gly Ser Ser Gly Leu Phe Arg Ala Val Ser Ala Phe Gly Val Val 
                85                  90                  95      


Gly Phe Val Arg Phe Leu Glu Gly Tyr Tyr Ile Val Leu Ile Thr Lys 
            100                 105                 110         


Arg Arg Lys Met Ala Asp Ile Gly Gly His Ala Ile Tyr Lys Val Glu 
        115                 120                 125             


Asp Thr Asn Met Ile Tyr Ile Pro Asn Asp Ser Val Arg Val Thr His 
    130                 135                 140                 


Pro Asp Glu Ala Arg Tyr Leu Arg Ile Phe Gln Asn Val Asp Leu Ser 
145                 150                 155                 160 


Ser Asn Phe Tyr Phe Ser Tyr Ser Tyr Asp Leu Ser His Ser Leu Gln 
                165                 170                 175     


Tyr Asn Leu Thr Val Leu Arg Met Pro Leu Glu Met Leu Lys Ser Glu 
            180                 185                 190         


Thr Thr Gln Asn Arg Gln Glu Ser Phe Asp Ile Phe Glu Asp Glu Gly 
        195                 200                 205             


Leu Ile Thr Gln Gly Gly Ser Gly Val Phe Gly Ile Cys Ser Glu Pro 
    210                 215                 220                 


Tyr Met Lys Tyr Val Trp Asn Gly Glu Leu Leu Asp Ile Ile Lys Asn 
225                 230                 235                 240 


Thr Val His Arg Asp Trp Leu Leu Tyr Ile Ile His Gly Phe Cys Gly 
                245                 250                 255     


Gln Ser Lys Leu Leu Ile Tyr Gly Arg Pro Val Tyr Val Thr Leu Ile 
            260                 265                 270         


Ala Arg Arg Ser Ser Lys Phe Ala Gly Thr Arg Phe Leu Lys Arg Gly 
        275                 280                 285             


Ala Asn Cys Glu Gly Asp Val Ala Asn Glu Val Glu Thr Glu Gln Ile 
    290                 295                 300                 


Leu Cys Asp Ala Ser Val Met Ser Phe Thr Ala Gly Ser Tyr Ser Ser 
305                 310                 315                 320 


Tyr Val Gln Val Arg Gly Ser Val Pro Leu Tyr Trp Ser Gln Asp Ile 
                325                 330                 335     


Ser Thr Met Met Pro Lys Pro Pro Ile Thr Leu Asp Gln Ala Asp Pro 
            340                 345                 350         


Phe Ala His Val Ala Ala Leu His Phe Asp Gln Met Phe Gln Arg Phe 
        355                 360                 365             


Gly Ser Pro Ile Ile Ile Leu Asn Leu Val Lys Glu Arg Glu Lys Arg 
    370                 375                 380                 


Lys His Glu Arg Ile Leu Ser Glu Glu Leu Val Ala Ala Val Thr Tyr 
385                 390                 395                 400 


Leu Asn Gln Phe Leu Pro Pro Glu His Thr Ile Val Tyr Ile Pro Trp 
                405                 410                 415     


Asp Met Ala Lys Tyr Thr Lys Ser Lys Leu Cys Asn Val Leu Asp Arg 
            420                 425                 430         


Leu Asn Val Ile Ala Glu Ser Val Val Lys Lys Thr Gly Phe Phe Val 
        435                 440                 445             


Asn Arg Pro Asp Ser Tyr Cys Ser Ile Leu Arg Pro Asp Glu Lys Trp 
    450                 455                 460                 


Asn Glu Leu Gly Gly Cys Val Ile Pro Thr Gly Arg Leu Gln Thr Gly 
465                 470                 475                 480 


Ile Leu Arg Thr Asn Cys Val Asp Cys Leu Asp Arg Thr Asn Thr Ala 
                485                 490                 495     


Gln Phe Met Val Gly Lys Cys Ala Leu Ala Tyr Gln Leu Tyr Ser Leu 
            500                 505                 510         


Gly Leu Ile Asp Lys Pro Asn Leu Gln Phe Asp Thr Asp Ala Val Arg 
        515                 520                 525             


Leu Phe Glu Glu Leu Tyr Glu Asp His Gly Asp Thr Leu Ser Leu Gln 
    530                 535                 540                 


Tyr Gly Gly Ser Gln Leu Val His Arg Val Lys Thr Tyr Arg Lys Ile 
545                 550                 555                 560 


Ala Pro Trp Thr Gln His Ser Lys Asp Ile Met Gln Thr Leu Ser Arg 
                565                 570                 575     


Tyr Tyr Ser Asn Ala Phe Ser Asp Ala Asp Arg Gln Asp Ser Ile Asn 
            580                 585                 590         


Leu Phe Leu Gly Val Phe His Pro Thr Glu Gly Lys Pro His Leu Trp 
        595                 600                 605             


Glu Leu Pro Thr Asp Phe Tyr Leu His His Lys Asn Thr Met Arg Leu 
    610                 615                 620                 


Leu Pro Thr Arg Arg Ser Tyr Thr Tyr Trp Trp Thr Pro Glu Val Ile 
625                 630                 635                 640 


Lys His Leu Pro Leu Pro Tyr Asp Glu Val Ile Cys Ala Val Asn Leu 
                645                 650                 655     


Lys Lys Leu Ile Val Lys Lys Phe His Lys Tyr Glu Glu Glu Ile Asp 
            660                 665                 670         


Ile His Asn Glu Phe Phe Arg Pro Tyr Glu Leu Ser Ser Phe Asp Asp 
        675                 680                 685             


Thr Phe Cys Leu Ala Met Thr Ser Ser Ala Arg Asp Phe Met Pro Lys 
    690                 695                 700                 


Thr Val Gly Ile Asp Pro Ser Pro Phe Thr Val Arg Lys Pro Asp Glu 
705                 710                 715                 720 


Thr Gly Lys Ser Val Leu Gly Asn Lys Ser Asn Arg Glu Glu Ala Val 
                725                 730                 735     


Leu Gln Arg Lys Thr Ala Ala Ser Ala Pro Pro Pro Pro Ser Glu Glu 
            740                 745                 750         


Ala Val Ser Ser Ser Ser Glu Asp Asp Ser Gly Thr Asp Arg Glu Glu 
        755                 760                 765             


Glu Gly Ser Val Ser Gln Arg Ser Thr Pro Val Lys Met Thr Asp Ala 
    770                 775                 780                 


Gly Asp Ser Ala Lys Val Thr Glu Asn Val Val Gln Pro Met Lys Glu 
785                 790                 795                 800 


Leu Tyr Gly Ile Asn Leu Ser Asp Gly Leu Ser Glu Glu Asp Phe Ser 
                805                 810                 815     


Ile Tyr Ser Arg Phe Val Gln Leu Gly Gln Ser Gln His Lys Gln Asp 
            820                 825                 830         


Lys Asn Ser Gln Gln Pro Cys Ser Arg Cys Ser Asp Gly Val Ile Lys 
        835                 840                 845             


Leu Thr Pro Ile Ser Ala Phe Ser Gln Asp Asn Ile Tyr Glu Val Gln 
    850                 855                 860                 


Pro Pro Arg Val Asp Arg Lys Ser Thr Glu Ile Phe Gln Ala His Ile 
865                 870                 875                 880 


Gln Ala Ser Gln Gly Ile Met Gln Pro Leu Gly Lys Glu Asp Ser Ala 
                885                 890                 895     


Met Tyr Arg Glu Tyr Ile Arg Asn Arg Tyr Leu 
            900                 905         


<210>  9
<211>  907
<212>  PRT
<213>  Mus musculus

<400>  9

Met Pro Thr Ala Ala Ala Pro Ile Ile Ser Ser Val Gln Lys Leu Val 
1               5                   10                  15      


Leu Tyr Glu Thr Arg Ala Arg Tyr Phe Leu Val Gly Ser Asn His Ala 
            20                  25                  30          


Glu Thr Lys Tyr Arg Val Leu Lys Ile Asp Arg Thr Glu Pro Lys Asp 
        35                  40                  45              


Leu Val Val Ile Asp Asp Arg His Val Tyr Thr Gln Gln Glu Val Arg 
    50                  55                  60                  


Glu Leu Leu Gly Arg Leu Asp Leu Gly Asn Arg Thr Lys Met Ser Gln 
65                  70                  75                  80  


Lys Gly Ser Ser Gly Leu Phe Arg Ala Val Ser Ala Phe Gly Val Val 
                85                  90                  95      


Gly Phe Val Arg Phe Leu Glu Gly Tyr Tyr Ile Val Leu Ile Thr Lys 
            100                 105                 110         


Arg Arg Lys Met Ala Asp Ile Gly Gly His Ala Ile Tyr Lys Ile Glu 
        115                 120                 125             


Asp Thr Ser Met Ile Tyr Ile Pro Asn Asp Ser Val Arg Ile Ser His 
    130                 135                 140                 


Pro Asp Glu Ala Arg Tyr Leu Arg Ile Phe Gln Asn Val Asp Leu Ser 
145                 150                 155                 160 


Ser Asn Phe Tyr Phe Ser Tyr Ser Tyr Asp Leu Ser His Ser Leu Gln 
                165                 170                 175     


Tyr Asn Leu Thr Val Leu Arg Met Pro Leu Glu Met Leu Lys Ser Glu 
            180                 185                 190         


Thr Ser Lys Ala Cys Gln Glu Ser Phe Asp Ile Phe Glu Asp Glu Gly 
        195                 200                 205             


Leu Ile Thr Gln Gly Gly Ser Gly Val Phe Gly Ile Ser Ser Glu Pro 
    210                 215                 220                 


Tyr Met Lys Tyr Val Trp Asn Gly Glu Leu Leu Asp Ile Ile Lys Asn 
225                 230                 235                 240 


Thr Val His Arg Asp Trp Leu Leu Tyr Ile Ile His Gly Phe Cys Gly 
                245                 250                 255     


Gln Ser Lys Leu Leu Ile Tyr Gly Arg Pro Val Tyr Val Thr Leu Ile 
            260                 265                 270         


Ala Arg Arg Ser Ser Arg Phe Ala Gly Thr Arg Phe Leu Lys Arg Gly 
        275                 280                 285             


Ala Asn Cys Glu Gly Asp Val Ala Asn Glu Val Glu Thr Glu Gln Ile 
    290                 295                 300                 


Leu Cys Asp Ala Ser Val Met Ser Phe Thr Ala Gly Ser Tyr Ser Ser 
305                 310                 315                 320 


Tyr Val Gln Val Arg Gly Ser Val Pro Leu Phe Trp Ser Gln Asp Ile 
                325                 330                 335     


Ser Thr Met Met Pro Lys Pro Pro Ile Thr Leu Asp Gln Ala Asp Pro 
            340                 345                 350         


Phe Ala His Val Ala Ala Leu His Phe Asp Gln Met Leu Gln Arg Phe 
        355                 360                 365             


Gly Ser Pro Ile Ile Ile Leu Asn Leu Val Lys Glu Arg Glu Lys Arg 
    370                 375                 380                 


Lys His Glu Arg Ile Leu Ser Glu Glu Leu Val Ala Ala Val Thr Tyr 
385                 390                 395                 400 


Leu Asn Gln Phe Leu Pro Pro Glu His Thr Ile Val Tyr Ile Pro Trp 
                405                 410                 415     


Asp Met Ala Lys Tyr Thr Lys Ser Lys Leu Cys Asn Val Leu Asp Arg 
            420                 425                 430         


Leu Asn Val Ile Ala Glu Ser Val Val Lys Lys Thr Gly Phe Phe Val 
        435                 440                 445             


Asn Arg Pro Asp Ser Tyr Cys Ser Ile Leu Arg Pro Asp Glu Lys Trp 
    450                 455                 460                 


Asn Glu Leu Gly Gly His Val Ile Pro Thr Gly Arg Leu Gln Thr Gly 
465                 470                 475                 480 


Ile Leu Arg Thr Asn Cys Val Asp Cys Leu Asp Arg Thr Asn Thr Ala 
                485                 490                 495     


Gln Phe Met Val Gly Lys Cys Ala Leu Ala Tyr Gln Leu Tyr Ser Leu 
            500                 505                 510         


Gly Leu Ile Asp Lys Pro Asn Leu Gln Phe Asp Thr Asp Ala Val Arg 
        515                 520                 525             


Leu Phe Glu Glu Leu Tyr Glu Asp His Gly Asp Thr Leu Ser Leu Gln 
    530                 535                 540                 


Tyr Gly Gly Ser Gln Leu Val His Arg Val Lys Thr Tyr Arg Lys Ile 
545                 550                 555                 560 


Ala Pro Trp Thr Gln His Ser Lys Asp Ile Met Gln Thr Leu Ser Arg 
                565                 570                 575     


Tyr Tyr Ser Asn Ala Phe Ser Asp Ala Asp Arg Gln Asp Ser Ile Asn 
            580                 585                 590         


Leu Phe Leu Gly Val Phe His Pro Thr Glu Gly Lys Pro His Leu Trp 
        595                 600                 605             


Glu Leu Pro Thr Asp Phe Tyr Leu His His Lys Asn Thr Met Ser Leu 
    610                 615                 620                 


Leu Pro Pro Arg Arg Ser Tyr Thr Tyr Trp Trp Thr Pro Glu Val Val 
625                 630                 635                 640 


Lys His Leu Pro Leu Pro Tyr Asp Glu Val Ile Cys Ala Ala Asn Leu 
                645                 650                 655     


Lys Lys Leu Met Val Lys Lys Phe His Arg Trp Glu Glu Glu Ile Asp 
            660                 665                 670         


Ile His Asn Glu Phe Phe Arg Pro Tyr Glu Leu Ser Ser Phe Asp Asp 
        675                 680                 685             


Thr Phe Cys Leu Ala Met Thr Ser Ser Ala Arg Asp Phe Met Pro Lys 
    690                 695                 700                 


Thr Val Gly Ile Asp Pro Ser Pro Phe Thr Val Arg Lys Pro Asp Glu 
705                 710                 715                 720 


Thr Gly Lys Ser Val Leu Gly Asn Lys Asn Thr Arg Glu Glu Ala Val 
                725                 730                 735     


Leu Gln Arg Lys Thr Ala Ala Ser Ala Pro Pro Pro Pro Ser Glu Glu 
            740                 745                 750         


Ala Val Ser Ser Ser Ser Glu Asp Asp Ser Gly Thr Asp Arg Glu Asp 
        755                 760                 765             


Glu Gly Ser Ile Ser Gln Arg Ser Thr Pro Val Lys Met Thr Asp Thr 
    770                 775                 780                 


Gly Asp Ser Ala Lys Ala Thr Glu Asn Val Val Gln Pro Met Lys Glu 
785                 790                 795                 800 


Val Tyr Gly Val Ser Leu Ser Ser Ser Leu Ser Glu Glu Asp His Ser 
                805                 810                 815     


Ile Tyr Ala Arg Phe Val Gln Leu Gly Gln Ser Gln His Lys Gln Asp 
            820                 825                 830         


Arg Gly Asn Gln Gln Leu Cys Ser Arg Cys Ser Asp Gly Val Ile Lys 
        835                 840                 845             


Leu Thr Pro Ile Ser Ala Phe Ser Gln Asp Asn Ile Tyr Glu Val Gln 
    850                 855                 860                 


Pro Pro Arg Val Asp Arg Lys Ser Thr Glu Ile Phe Gln Ala His Ile 
865                 870                 875                 880 


Gln Ala Ser Gln Gly Ile Met Gln Pro Leu Gly Lys Glu Asp Thr Ala 
                885                 890                 895     


Met Tyr Arg Glu Tyr Ile Arg Asn Arg Tyr Leu 
            900                 905         


<210>  10
<211>  907
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met Pro Thr Ala Ala Ala Pro Ile Ile Ser Ser Val Gln Lys Leu Val 
1               5                   10                  15      


Leu Tyr Glu Thr Arg Ala Arg Tyr Phe Leu Val Gly Ser Asn His Ala 
            20                  25                  30          


Glu Thr Lys Phe Arg Val Leu Lys Ile Asp Arg Thr Glu Pro Lys Asp 
        35                  40                  45              


Leu Val Val Ile Asp Asp Arg His Val Tyr Thr Gln Gln Glu Val Arg 
    50                  55                  60                  


Glu Leu Leu Gly Arg Leu Asp Leu Gly Asn Arg Thr Lys Leu Ser Gln 
65                  70                  75                  80  


Lys Gly Ser Ser Gly Leu Phe Arg Ala Val Ser Ala Phe Gly Val Val 
                85                  90                  95      


Gly Phe Val Arg Phe Leu Glu Gly Tyr Tyr Ile Val Leu Ile Thr Lys 
            100                 105                 110         


Arg Arg Lys Met Ala Asp Ile Gly Gly His Ala Ile Tyr Lys Ile Glu 
        115                 120                 125             


Asp Thr Ser Met Ile Tyr Ile Pro Asn Asp Ser Val Arg Ile Thr His 
    130                 135                 140                 


Pro Asp Glu Ala Arg Tyr Leu Arg Ile Phe Gln Asn Val Asp Leu Ser 
145                 150                 155                 160 


Ser Asn Phe Tyr Phe Ser Tyr Ser Tyr Asp Leu Ser His Ser Leu Gln 
                165                 170                 175     


Tyr Asn Leu Thr Val Leu Arg Met Pro Leu Glu Met Leu Lys Ser Glu 
            180                 185                 190         


Thr Ser Lys Thr Cys Gln Glu Ser Phe Asp Ile Phe Glu Asp Glu Gly 
        195                 200                 205             


Leu Thr Thr Gln Gly Gly Ser Gly Val Phe Gly Ile Ser Ser Glu Pro 
    210                 215                 220                 


Tyr Met Lys Tyr Val Trp Asn Gly Glu Leu Leu Asp Ile Ile Lys Asn 
225                 230                 235                 240 


Ser Val His Arg Asp Trp Leu Leu Tyr Ile Ile His Gly Phe Cys Gly 
                245                 250                 255     


Gln Ser Lys Leu Leu Ile Tyr Gly Arg Pro Val Tyr Val Thr Leu Ile 
            260                 265                 270         


Ala Arg Arg Ser Ser Arg Phe Ala Gly Thr Arg Phe Leu Lys Arg Gly 
        275                 280                 285             


Ala Asn Cys Glu Gly Asp Val Ala Asn Glu Val Glu Thr Glu Gln Ile 
    290                 295                 300                 


Leu Cys Asp Ala Ser Val Met Ser Phe Thr Ala Gly Ser Tyr Ser Ser 
305                 310                 315                 320 


Tyr Val Gln Val Arg Gly Ser Val Pro Leu Phe Trp Ser Gln Asp Ile 
                325                 330                 335     


Ser Thr Met Met Pro Lys Pro Pro Ile Thr Leu Asp Gln Ala Asp Pro 
            340                 345                 350         


Phe Ala His Ile Ala Ala Leu His Phe Asp Gln Met Leu Gln Arg Phe 
        355                 360                 365             


Gly Ser Pro Ile Ile Ile Leu Asn Leu Val Lys Glu Arg Glu Lys Arg 
    370                 375                 380                 


Lys His Glu Arg Ile Leu Ser Glu Glu Leu Val Ala Ala Val Thr Tyr 
385                 390                 395                 400 


Leu Asn Gln Phe Leu Pro Pro Glu His Ser Ile Val Tyr Ile Pro Trp 
                405                 410                 415     


Asp Met Ala Lys Tyr Thr Lys Ser Lys Leu Cys Asn Val Leu Asp Arg 
            420                 425                 430         


Leu Asn Val Ile Ala Glu Ser Val Val Lys Lys Thr Gly Phe Phe Val 
        435                 440                 445             


Asn Arg Pro Asp Ser Tyr Cys Ser Val Leu Arg Pro Asp Glu Lys Trp 
    450                 455                 460                 


Asn Glu Leu Gly Gly Arg Val Ile Pro Thr Gly Arg Leu Gln Thr Gly 
465                 470                 475                 480 


Ile Leu Arg Thr Asn Cys Val Asp Cys Leu Asp Arg Thr Asn Thr Ala 
                485                 490                 495     


Gln Phe Met Val Gly Lys Cys Ala Leu Ala Tyr Gln Leu Tyr Ser Leu 
            500                 505                 510         


Gly Leu Ile Asp Lys Pro Asn Leu Gln Phe Asp Thr Asp Ala Val Arg 
        515                 520                 525             


Leu Phe Glu Glu Leu Tyr Glu Asp His Gly Asp Thr Leu Ser Leu Gln 
    530                 535                 540                 


Tyr Gly Gly Ser Gln Leu Val His Arg Val Lys Thr Tyr Arg Lys Ile 
545                 550                 555                 560 


Ala Pro Trp Thr Gln His Ser Lys Asp Ile Met Gln Thr Leu Ser Arg 
                565                 570                 575     


Tyr Tyr Ser Asn Ala Phe Ser Asp Ala Asp Arg Gln Asp Ser Ile Asn 
            580                 585                 590         


Leu Phe Leu Gly Val Phe His Pro Thr Glu Gly Lys Pro His Leu Trp 
        595                 600                 605             


Glu Leu Pro Thr Asp Phe Tyr Leu His His Lys Asn Thr Met Ser Leu 
    610                 615                 620                 


Leu Pro Pro Lys Arg Ser Tyr Thr His Trp Trp Thr Pro Glu Val Val 
625                 630                 635                 640 


Lys His Leu Pro Leu Pro Tyr Asp Glu Val Ile Cys Ala Ala Asn Leu 
                645                 650                 655     


Lys Lys Leu Thr Val Lys Lys Phe His Arg Trp Glu Glu Glu Ile Asp 
            660                 665                 670         


Ile His Asn Glu Phe Phe Arg Pro Tyr Glu Leu Ser Ser Phe Asp Asp 
        675                 680                 685             


Thr Phe Cys Leu Ala Met Thr Ser Ser Ala Arg Asp Phe Met Pro Lys 
    690                 695                 700                 


Thr Ile Gly Ile Asp Pro Ser Pro Phe Thr Val Arg Lys Pro Asp Glu 
705                 710                 715                 720 


Thr Gly Lys Ser Val Leu Gly Asn Lys Ser Asn Arg Glu Glu Ala Val 
                725                 730                 735     


Leu Gln Arg Lys Thr Ala Ala Ser Ala Pro Pro Pro Pro Ser Glu Glu 
            740                 745                 750         


Ala Val Ser Ser Ser Ser Glu Asp Asp Ser Gly Thr Asp Arg Glu Asp 
        755                 760                 765             


Glu Gly Ser Ile Ser Gln Arg Ser Thr Pro Val Lys Met Thr Asp Thr 
    770                 775                 780                 


Gly Asp Ser Ala Lys Val Thr Glu Ser Val Ala Gln Pro Met Lys Glu 
785                 790                 795                 800 


Val Tyr Gly Val Ser Leu Ser Arg Ser Leu Ser Glu Glu Asp His Ser 
                805                 810                 815     


Ile Tyr Ala Arg Phe Val Gln Leu Gly Gln Ser Gln His Arg Gln Asp 
            820                 825                 830         


Trp Ser Ser Pro Gln Met Cys Ala Arg Cys Ser Asp Gly Val Ile Lys 
        835                 840                 845             


Leu Thr Pro Ile Ser Ala Phe Ser Gln Asp Asn Ile Tyr Glu Val Gln 
    850                 855                 860                 


Pro Pro Arg Val Asp Arg Lys Ser Thr Glu Ile Phe Gln Ala His Ile 
865                 870                 875                 880 


Gln Ala Ser Gln Gly Ile Met Gln Pro Leu Gly Lys Glu Asp Thr Ala 
                885                 890                 895     


Ile Tyr Arg Glu Tyr Ile Arg Asn Arg Tyr Leu 
            900                 905         


