                         б

<110>  ҽҩ޹˾
 
<120>  IL-1µĿ塢Ʊ;

<130>  SH363-19P422617

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  1

Gly Tyr Leu Phe Thr Gly Tyr Tyr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  2

Ile Ser Cys Tyr Asn Gly Asp Thr 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  3

Ser Arg Ser Asp Tyr Tyr Gly Thr Ser Asp Tyr 
1               5                   10      


<210>  4
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  4

Ser Ser Val Ser Tyr 
1               5   


<210>  5
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  5

Thr Thr Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Gln Arg Ile Ile Tyr Pro Pro Thr 
1               5                   


<210>  7
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  7

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Leu Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Ser Cys Tyr Asn Gly Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Phe Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Asp Tyr Tyr Gly Thr Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  8
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Thr Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ile Ile Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  9
<211>  118
<212>  PRT
<213>  Homo

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Leu Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Ser Cys Tyr Asn Gly Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Phe Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Asp Tyr Tyr Gly Thr Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  10
<211>  106
<212>  PRT
<213>  Homo

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              


Thr Thr Ser Thr Leu Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Met Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ile Ile Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  11
<211>  118
<212>  PRT
<213>  Homo

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Leu Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Ser Cys Tyr Asn Gly Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Phe Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Asp Tyr Tyr Gly Thr Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  12
<211>  106
<212>  PRT
<213>  Homo

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              


Thr Thr Ser Thr Leu Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Met Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ile Ile Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  13
<211>  118
<212>  PRT
<213>  Homo

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Leu Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Ser Cys Tyr Asn Gly Asp Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Asp Tyr Tyr Gly Thr Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  14
<211>  106
<212>  PRT
<213>  Homo

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Thr Leu Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ile Ile Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  15
<211>  354
<212>  DNA
<213>  Mus musculus

<400>  15
gaagtgcagc tccagcagag cggaccagaa ctggtgaaga ccggagccag cgtgaagatc       60

tcctgcaaag ccagcggcta tctgttcacc ggctactaca tgcattgggt gaagcagagc      120

cacggcaaga gcctcgagtg gatcggcttc atctcctgct acaacggcga caccacctac      180

aaccagaagt tcaaggacaa ggccaccttc accgtggaca ccagcagcaa caccgcctac      240

atgcagttca acagcctgac cagcgaggac agcgccgtgt actattgcag ccggagcgac      300

tactacggca caagcgacta ttggggacag ggcacaaccc tgaccgtgtc tagc            354


<210>  16
<211>  318
<212>  DNA
<213>  Mus musculus

<400>  16
cagatcgtgc tgacccagag cccagccatc atgagcgcta gccccggcga gaaagtgacc       60

atcacctgta gcgcctctag cagcgtgtcc tacatgcatt ggttccagca gaagcccggc      120

accagcccaa agctctggat ctacaccacc agcacactgg ccagcggagt gccagctaga      180

ttcagcggaa gcggcagcgg cacatcttat agcctgacca tcagcaggat ggaggccgaa      240

gacgcagcca cctactattg ccagcagcgg atcatctacc ctcctacctt tggcggcggc      300

acaaagctgg agatcaag                                                    318


<210>  17
<211>  354
<212>  DNA
<213>  Homo

<400>  17
caggtgcagc tggtgcagag cggagcagaa gtggtgaagc caggagccag cgtgaagatc       60

agctgcaaag ccagcggcta tctgttcacc ggctactaca tgcattgggt gaagcaggcc      120

ccaggcaaag gactggagtg gatcgggttc attagctgct acaacggcga caccacctac      180

aaccagaagt tccagggcaa ggccaccttc accgtggata ccagcaccaa caccgcctac      240

atggagttca acagcctgac cagcgaggac accgccgtgt actattgcag ccggagcgac      300

tactacggca caagcgacta ttggggccag ggaacaaccc tgaccgtgtc tagc            354


<210>  18
<211>  318
<212>  DNA
<213>  Homo

<400>  18
gaaatcgtgc tgacccagag cccagctacc atgagcgcct ctccaggaga gagagtgacc       60

atctcttgca gagccagcag cagcgtgtcc tacatgcatt ggttccagca gaagccagga      120

caggccccac gcctctggat ctacacaaca agcaccctgg ccaccggagt gccagctaga      180

ttcagcggaa gcggcagcgg cacagattat accctgacca tcagcaggat ggagccagag      240

gacgcagcca cctactattg ccagcagcgg atcatctacc ctcctacctt tggcggcggc      300

acaaagctgg agatcaag                                                    318


<210>  19
<211>  354
<212>  DNA
<213>  Homo

<400>  19
caggtgcagc tggtgcagtc aggagcagaa gtggtgaagc ccggagccag cgtgaaagtg       60

tcttgcaagg ccagcggcta tctgttcacc ggatactaca tgcattgggt ccggcaggcc      120

ccaggacagg gactggagtg gatcgggttc attagctgct acaacggcga caccacctac      180

aaccagaagt tccagggcag ggccaccttc acagtggaca ccagcaccaa caccgcctac      240

atggagttca gcagcctgac cagcgaggac acagccgtgt actattgcag ccggagcgac      300

tactacggca caagcgacta ttggggccag ggaacaaccc tgaccgtgtc tagc            354


<210>  20
<211>  318
<212>  DNA
<213>  Homo

<400>  20
gaaatcgtgc tgacccagag cccagctaca ctgagcgcct ctccaggaga gagagtgacc       60

atctcttgca gagccagcag cagcgtgtcc tacctgcatt ggtaccagca gaagcccgga      120

caggccccac gcctctggat ctacaccaca agcaccctgg ccaccggagt gccagctaga      180

ttcagcggaa gcggcagcgg cacagattat accctgacca tcagcaggat ggagccagag      240

gacgcagcca cctactattg ccagcagcgg atcatctacc ctcctacctt tggcggcggc      300

acaaagctgg agatcaag                                                    318


<210>  21
<211>  354
<212>  DNA
<213>  Homo

<400>  21
caggtgcagc tggtgcagtc aggagcagaa gtggtgaagc ccggagccag cgtgaaagtg       60

tcttgcaagg ccagcggcta tctgtttacc ggctactaca tgcattgggt ccggcaggca      120

cccggacagg gcctggagtg gatcggttgg attagctgct acaacggcga caccaactac      180

gcccagaagt tccagggcag ggtgaccatc accgtggaca ccagcaccaa caccgcctac      240

atggagctga gcagcctgac aagcgaggac acagccgtgt actattgcag ccggagcgac      300

tactacggca caagcgacta ttggggccag ggaacaaccc tgaccgtgtc tagc            354


<210>  22
<211>  318
<212>  DNA
<213>  Homo

<400>  22
gaaatcgtgc tgacccagag cccagctaca ctgagcgcct ctccaggaga aagagccacc       60

atctcttgca gagccagcag cagcgtgtcc tacctgcatt ggtaccagca gaagcccgga      120

caggctccca gactgctgat ctacaccacc agcaccctgg ctaccggagt gccagccaga      180

ttcagcggaa gcggcagcgg cacagattat accctgacca tcagcagact ggagccagag      240

gacgcagcca cctactattg ccagcagcgg atcatctacc ctcctacctt tggcggcggc      300

acaaagctgg agatcaag                                                    318


<210>  23
<211>  387
<212>  PRT
<213>  Synthetic

<400>  23

Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln Gln Lys 
1               5                   10                  15      


Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His Leu Gln 
            20                  25                  30          


Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe 
            100                 105                 110         


Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ala Glu 
        115                 120                 125             


Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp Ile Thr 
    130                 135                 140                 


Asp Phe Thr Met Gln Phe Val Ser Ser Lys Leu Glu Asn Leu Tyr Phe 
145                 150                 155                 160 


Gln Gly Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                165                 170                 175     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            180                 185                 190         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        195                 200                 205             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    210                 215                 220                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
225                 230                 235                 240 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                245                 250                 255     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            260                 265                 270         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        275                 280                 285             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    290                 295                 300                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
305                 310                 315                 320 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                325                 330                 335     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            340                 345                 350         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        355                 360                 365             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    370                 375                 380                 


Pro Gly Lys 
385         


<210>  24
<211>  338
<212>  PRT
<213>  Synthetic

<400>  24

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr His His His His 
                325                 330                 335     


His His 
        


<210>  25
<211>  160
<212>  PRT
<213>  Synthetic

<400>  25

Met Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln Gln 
1               5                   10                  15      


Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His Leu 
            20                  25                  30          


Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe Val 
        35                  40                  45              


Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys 
    50                  55                  60                  


Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr 
65                  70                  75                  80  


Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met 
                85                  90                  95      


Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu 
            100                 105                 110         


Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ala 
        115                 120                 125             


Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp Ile 
    130                 135                 140                 


Thr Asp Phe Thr Met Gln Phe Val Ser Ser His His His His His His 
145                 150                 155                 160 


<210>  26
<211>  118
<212>  PRT
<213>  Homo

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp Tyr Asp Gly Asp Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Arg Thr Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  27
<211>  330
<212>  PRT
<213>  Homo

<400>  27

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  28
<211>  107
<212>  PRT
<213>  Homo

<400>  28

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  29
<211>  107
<212>  PRT
<213>  Homo

<400>  29

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  30
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  30

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Tyr Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Tyr Asp Val Ser Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  31
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  31
gatgtgcagc tcgtggaatc aggaggagga ctggtgcagc ccggcggcag cagaaagctg       60

tcttgcgccg ccagcggctt cacctttagc accttcggaa tgcattgggt ccggcaggct      120

ccagagaagg gactcgagtg ggtggcctac atcagcagcg gcagctacac catctactac      180

gccgacaccg tgcggggaag attcaccatc agccgggaca accccaagaa caccctgttc      240

ctgcagatga ccagcctgag gagcgaggat accgccatgt actattgcgc cagagacgac      300

tacgacgtgt cctactacgc catggactat tggggacagg gcacaagcgt gacagtgtct      360

agc                                                                    363


<210>  32
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  32

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Ser Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  33
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  33
gatatcgtgc tgacccagtc tccagcctct ctggcagtgt ctctgggcca gagagccaca       60

atctcttgca gagcctccga gagcgtggag tactacggca ccagcctcat gcagtggtac      120

cagcagaaac ccggacagcc tcctaagctg ctgatctacg ccgcctctaa cgtggagagc      180

ggagtgccag ccagattcag cggaagcgga agcggcaccg acttcagcct gaacatccac      240

ccagtggagg aggacgacat cgccatgtac ttctgccagc agagcaggaa agtgccctct      300

ctgacctttg gcgccggaac caagctggaa ctgaag                                336


<210>  34
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  34

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Tyr Thr Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Tyr Asp Val Ser Asn Tyr Val Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  35
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  35
gacgtgcagc tcgtggagtc cggaggaggg ctggtgcagc ccggaggaag ccggaagctg       60

tcctgtgccg cctctggctt caccttttct acatttggca tgcactgggt gaggcaggcc      120

ccagagaagg ggctggagtg ggtggcctac atcagctccg gctcttatac cacatactat      180

gccgacaccg tgcggggcag attcacaatc agccgggata accctaagaa taccctgttt      240

ctgcagatga cctccctgag gtctgaggat acagccatgt actattgcgc ccgcgacgat      300

tacgacgtgt ctaactacgt gatggattat tgggggcagg gcaccagcgt gacagtgtct      360

agc                                                                    363


<210>  36
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  36

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Val Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Ser Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  37
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  37
gatatcgtgc tgacccagtc tccagcctct ctggcagtgt ctctgggcca gagagccaca       60

atctcttgca gagcctccga gagcgtggag tactacggca ccagcctcat gcagtggtac      120

cagcagaaac ccggacagcc tcctaagctg ctgatctacg ccgcctctaa cgtggagagc      180

ggagtgccag ccagattcac aggaagcgga agcggcaccg tattcagcct gaacatccac      240

ccagtggagg aggacgacat cgccatgtac ttctgccagc agagcaggaa agtgccctct      300

ctgacctttg gcgccggaac caagctggaa ctgaag                                336

<210>  38
<211>  8
<212>  PRT
<213>  Synthetic

<400>  1

Ile Ser Ala Tyr Asn Gly Asp Thr 
1               5 

