                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  COMPOSITIONS AND METHODS FOR DIAGNOSIS OF CARDIOVASCULAR DISEASE

<130>  00015-357WO1

<140>  Not yet assigned
<141>  2019-11-01

<150>  US 62/755,366
<151>  2018-11-02

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain of AG23


<220>
<221>  CDS
<222>  (1)..(1320)

<400>  1
gag gtc cag ctg cag cag tct gga cct gag ctg gtg aaa cct ggg gct         48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag ata tcc tgc aag gct tct ggt tac tca ttc act ggc tac         96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr           
            20                  25                  30                    

tac atg aac tgg gtg agg caa agt cct gaa aag aac ctt gag tgg att        144
Tyr Met Asn Trp Val Arg Gln Ser Pro Glu Lys Asn Leu Glu Trp Ile           
        35                  40                  45                        

gga gag att aat cct tac act ggt ggt acg acc tat aat cag aag ttc        192
Gly Glu Ile Asn Pro Tyr Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe           
    50                  55                  60                            

aag gcc agg gcc aca ttg act gta gac aaa tcc tcc agt aca gcc tac        240
Lys Ala Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

gtg cag ctc aag agc ctg aca tct gag gac tct gca gtt tat ttt tgt        288
Val Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys           
                85                  90                  95                

gta agt tgg gat tac gac ctt gac tac tgg ggc caa ggc acc act ctc        336
Val Ser Trp Asp Tyr Asp Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu           
            100                 105                 110                   

aca gtc tcc tca gcc aaa acg aca ccc cca tct gtc tat cca ctg gcc        384
Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala           
        115                 120                 125                       

cct gga tct gct gcc caa act aac tcc atg gtg acc ctg gga tgc ctg        432
Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu           
    130                 135                 140                           

gtc aag ggc tat ttc cct gag cca gtg aca gtg acc tgg aac tct gga        480
Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly           
145                 150                 155                 160           

tcc ctg tcc agc ggt gtg cac acc ttc cca gct gtc ctg cag tct gac        528
Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp           
                165                 170                 175               

ctc tac act ctg agc agc tca gtg act gtc ccc tcc agc acc tgg ccc        576
Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro           
            180                 185                 190                   

agc cag acc gtc acc tgc aac gtt gcc cac ccg gcc agc agc acc aag        624
Ser Gln Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys           
        195                 200                 205                       

gtg gac aag aaa att gtg ccc agg gat tgt ggt tgt aag cct tgc ata        672
Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile           
    210                 215                 220                           

tgt aca gtc cca gaa gta tca tct gtc ttc atc ttc ccc cca aag ccc        720
Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro           
225                 230                 235                 240           

aag gat gtg ctc acc att act ctg act cct aag gtc acg tgt gtt gtg        768
Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val           
                245                 250                 255               

gta gac atc agc aag gat gat ccc gag gtc cag ttc agc tgg ttt gta        816
Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val           
            260                 265                 270                   

gat gat gtg gag gtg cac aca gct cag acg aaa ccc cgg gag gag cag        864
Asp Asp Val Glu Val His Thr Ala Gln Thr Lys Pro Arg Glu Glu Gln           
        275                 280                 285                       

atc aac agc act ttc cgt tca gtc agt gaa ctt ccc atc atg cac cag        912
Ile Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln           
    290                 295                 300                           

gac tgg ctc aat ggc aag gag ttc aaa tgc agg gtc aac agt gca gct        960
Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala           
305                 310                 315                 320           

ttc cct gcc ccc atc gag aaa acc atc tcc aaa acc aaa ggc aga ccg       1008
Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro           
                325                 330                 335               

aag gct cca cag gtg tac acc att cca cct ccc aag gag cag atg gcc       1056
Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala           
            340                 345                 350                   

aag gat aaa gtc agt ctg acc tgc atg ata aca aac ttc ttc cct gaa       1104
Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asn Phe Phe Pro Glu           
        355                 360                 365                       

gac att act gtg gag tgg cag tgg aat ggg cag cca gcg gag aac tac       1152
Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr           
    370                 375                 380                           

aag aac act cag ccc atc atg gac aca gat ggc tct tac ttc gtc tac       1200
Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr           
385                 390                 395                 400           

agc aag ctc aat gtg cag aag agc aac tgg gag gca gga aat act ttc       1248
Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe           
                405                 410                 415               

acc tgc tct gtg tta tat gag ggc ctg cac aac cac cat act gag aag       1296
Thr Cys Ser Val Leu Tyr Glu Gly Leu His Asn His His Thr Glu Lys           
            420                 425                 430                   

agc ctc tcc cac tct cct ggt aaa                                       1320
Ser Leu Ser His Ser Pro Gly Lys                                           
        435                 440                                           


<210>  2
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ser Pro Glu Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Tyr Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ala Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Val Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Ser Trp Asp Tyr Asp Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             


Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro 
            180                 185                 190         


Ser Gln Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile 
    210                 215                 220                 


Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val 
            260                 265                 270         


Asp Asp Val Glu Val His Thr Ala Gln Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Ile Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala 
305                 310                 315                 320 


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro 
                325                 330                 335     


Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala 
            340                 345                 350         


Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asn Phe Phe Pro Glu 
        355                 360                 365             


Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr 
    370                 375                 380                 


Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr 
385                 390                 395                 400 


Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe 
                405                 410                 415     


Thr Cys Ser Val Leu Tyr Glu Gly Leu His Asn His His Thr Glu Lys 
            420                 425                 430         


Ser Leu Ser His Ser Pro Gly Lys 
        435                 440 


<210>  3
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain Ag23


<220>
<221>  CDS
<222>  (1)..(639)

<400>  3
caa att gtt ctc acc cag tct cca gca ttc atg tct gca tct cca ggg         48
Gln Ile Val Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Ser Pro Gly           
1               5                   10                  15                

gag aag gtc acc atg acc tgc agt gcc agc tca agt gta agt tac atg         96
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met           
            20                  25                  30                    

cac tgg tac cag cag aag tca ggc acg tcc ccc aaa aga tgg att tat        144
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr           
        35                  40                  45                        

gcc aca tcc aaa gtg gct tct ggg gtc cct gct cgc ttc agt ggc agt        192
Ala Thr Ser Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggg tct ggg acc tct tac tct ctc aca atc agc agc atg gag gct gaa        240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu           
65                  70                  75                  80            

gat gct gcc act tat tac tgc ctg cag tgg agt agt aac cca tac acg        288
Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Asn Pro Tyr Thr           
                85                  90                  95                

ttc gga ggg ggg acc aag ctg gag ata aaa cgg gct gat gct gca cca        336
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro           
            100                 105                 110                   

act gta tcc atc ttc cca cca tcc agt gag cag tta aca tct gga ggt        384
Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly           
        115                 120                 125                       

gcc tca gtc gtg tgc ttc ttg aac aac ttc tac ccc aaa gac atc aat        432
Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn           
    130                 135                 140                           

gtc aag tgg aag att gat ggc agt gaa cga caa aat ggc gtc ctg aac        480
Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn           
145                 150                 155                 160           

agt tgg act gat cag gac agc aaa gac agc acc tac agc atg agc agc        528
Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser           
                165                 170                 175               

acc ctc acg ttg acc aag gac gag tat gaa cga cat aac agc tat acc        576
Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr           
            180                 185                 190                   

tgt gag gcc act cac aag aca tca act tca ccc att gtc aag agc ttc        624
Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe           
        195                 200                 205                       

aac agg aat gag tgt                                                    639
Asn Arg Asn Glu Cys                                                       
    210                                                                   


<210>  4
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Gln Ile Val Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Asn Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


