                               SEQUENCE LISTING

<110> BAYMEDICA, INC.
 
<120> CANNABINOID ANALOGS AND METHODS FOR THEIR PREPARATION

<130> 104059-000310PC-1161377

<140> PCT/US2019/059237
<141> 2019-10-31

<150> 62/767,447
<151> 2018-11-14

<150> 62/753,708
<151> 2018-10-31

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 579
<212> PRT
<213> Streptomyces sp.

<400> 1
Met Glu Leu Ala Leu Pro Ala Glu Leu Ala Pro Thr Leu Pro Glu Ala 
1               5                   10                  15      


Leu Arg Leu Arg Ser Glu Gln Gln Pro Asp Thr Val Ala Tyr Val Phe 
            20                  25                  30          


Leu Arg Asp Gly Glu Thr Pro Glu Glu Thr Leu Thr Tyr Gly Arg Leu 
        35                  40                  45              


Asp Arg Ala Ala Arg Ala Arg Ala Ala Ala Leu Glu Ala Ala Gly Leu 
    50                  55                  60                  


Ala Gly Gly Thr Ala Val Leu Leu Tyr Pro Ser Gly Leu Glu Phe Val 
65                  70                  75                  80  


Ala Ala Leu Leu Gly Cys Met Tyr Ala Gly Thr Ala Gly Ala Pro Val 
                85                  90                  95      


Gln Val Pro Thr Arg Arg Arg Gly Met Glu Arg Ala Arg Arg Ile Ala 
            100                 105                 110         


Asp Asp Ala Gly Ala Lys Thr Ile Leu Thr Thr Thr Ala Val Lys Arg 
        115                 120                 125             


Glu Val Glu Glu His Phe Ala Asp Leu Leu Thr Gly Leu Thr Val Ile 
    130                 135                 140                 


Asp Thr Glu Ser Leu Pro Asp Val Pro Asp Asp Ala Pro Ala Val Arg 
145                 150                 155                 160 


Leu Pro Gly Pro Asp Asp Val Ala Leu Leu Gln Tyr Thr Ser Gly Ser 
                165                 170                 175     


Thr Gly Asp Pro Lys Gly Val Glu Val Thr His Ala Asn Phe Arg Ala 
            180                 185                 190         


Asn Val Ala Glu Thr Val Glu Leu Trp Pro Val Arg Ser Asp Gly Thr 
        195                 200                 205             


Val Val Asn Trp Leu Pro Leu Phe His Asp Met Gly Leu Met Phe Gly 
    210                 215                 220                 


Val Val Met Pro Leu Phe Thr Gly Val Pro Ala Tyr Leu Met Ala Pro 
225                 230                 235                 240 


Gln Ser Phe Ile Arg Arg Pro Ala Arg Trp Leu Glu Ala Ile Ser Arg 
                245                 250                 255     


Phe Arg Gly Thr His Ala Ala Ala Pro Ser Phe Ala Tyr Glu Leu Cys 
            260                 265                 270         


Val Arg Ser Val Ala Asp Thr Gly Leu Pro Ala Gly Leu Asp Leu Ser 
        275                 280                 285             


Ser Trp Arg Val Ala Val Asn Gly Ala Glu Pro Val Arg Trp Thr Ala 
    290                 295                 300                 


Val Ala Asp Phe Thr Glu Ala Tyr Ala Pro Ala Gly Phe Arg Pro Gln 
305                 310                 315                 320 


Ala Met Cys Pro Gly Tyr Gly Leu Ala Glu Asn Thr Leu Lys Leu Ser 
                325                 330                 335     


Gly Ser Pro Glu Asp Arg Pro Pro Thr Leu Leu Arg Ala Asp Ala Ala 
            340                 345                 350         


Ala Leu Gln Asp Gly Arg Val Val Pro Leu Thr Gly Pro Gly Thr Asp 
        355                 360                 365             


Gly Val Arg Leu Val Gly Ser Gly Val Thr Val Pro Ser Ser Arg Val 
    370                 375                 380                 


Ala Val Val Asp Pro Gly Thr Gly Thr Glu Gln Pro Ala Gly Arg Val 
385                 390                 395                 400 


Gly Glu Ile Trp Ile Asn Gly Pro Cys Val Ala Arg Gly Tyr His Gly 
                405                 410                 415     


Arg Pro Ala Glu Ser Ala Glu Ser Phe Gly Ala Arg Ile Ala Gly Gln 
            420                 425                 430         


Glu Ala Arg Gly Thr Trp Leu Arg Thr Gly Asp Leu Gly Phe Leu His 
        435                 440                 445             


Asp Gly Glu Val Phe Val Ala Gly Arg Leu Lys Asp Val Val Ile His 
    450                 455                 460                 


Gln Gly Arg Asn Phe Tyr Pro Gln Asp Ile Glu Leu Ser Ala Glu Val 
465                 470                 475                 480 


Ser Asp Arg Ala Leu His Pro Asn Cys Ala Ala Ala Phe Ala Leu Asp 
                485                 490                 495     


Asp Gly Arg Thr Glu Arg Leu Val Leu Leu Val Glu Ala Asp Gly Arg 
            500                 505                 510         


Ala Leu Arg Asn Gly Gly Ala Asp Ala Leu Arg Ala Arg Val His Asp 
        515                 520                 525             


Ala Val Trp Asp Arg Gln Arg Leu Arg Ile Asp Glu Ile Val Leu Leu 
    530                 535                 540                 


Arg Arg Gly Ala Leu Pro Lys Thr Ser Ser Gly Lys Val Gln Arg Arg 
545                 550                 555                 560 


Leu Ala Arg Ser Arg Tyr Leu Asp Gly Glu Phe Gly Pro Ala Pro Ala 
                565                 570                 575     


Arg Glu Ala 
            


<210> 2
<211> 543
<212> PRT
<213> Cannabis sativa

<400> 2
Met Glu Lys Ser Gly Tyr Gly Arg Asp Gly Ile Tyr Arg Ser Leu Arg 
1               5                   10                  15      


Pro Pro Leu His Leu Pro Asn Asn Asn Asn Leu Ser Met Val Ser Phe 
            20                  25                  30          


Leu Phe Arg Asn Ser Ser Ser Tyr Pro Gln Lys Pro Ala Leu Ile Asp 
        35                  40                  45              


Ser Glu Thr Asn Gln Ile Leu Ser Phe Ser His Phe Lys Ser Thr Val 
    50                  55                  60                  


Ile Lys Val Ser His Gly Phe Leu Asn Leu Gly Ile Lys Lys Asn Asp 
65                  70                  75                  80  


Val Val Leu Ile Tyr Ala Pro Asn Ser Ile His Phe Pro Val Cys Phe 
                85                  90                  95      


Leu Gly Ile Ile Ala Ser Gly Ala Ile Ala Thr Thr Ser Asn Pro Leu 
            100                 105                 110         


Tyr Thr Val Ser Glu Leu Ser Lys Gln Val Lys Asp Ser Asn Pro Lys 
        115                 120                 125             


Leu Ile Ile Thr Val Pro Gln Leu Leu Glu Lys Val Lys Gly Phe Asn 
    130                 135                 140                 


Leu Pro Thr Ile Leu Ile Gly Pro Asp Ser Glu Gln Glu Ser Ser Ser 
145                 150                 155                 160 


Asp Lys Val Met Thr Phe Asn Asp Leu Val Asn Leu Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Phe Pro Ile Val Asp Asp Phe Lys Gln Ser Asp Thr Ala 
            180                 185                 190         


Ala Leu Leu Tyr Ser Ser Gly Thr Thr Gly Met Ser Lys Gly Val Val 
        195                 200                 205             


Leu Thr His Lys Asn Phe Ile Ala Ser Ser Leu Met Val Thr Met Glu 
    210                 215                 220                 


Gln Asp Leu Val Gly Glu Met Asp Asn Val Phe Leu Cys Phe Leu Pro 
225                 230                 235                 240 


Met Phe His Val Phe Gly Leu Ala Ile Ile Thr Tyr Ala Gln Leu Gln 
                245                 250                 255     


Arg Gly Asn Thr Val Ile Ser Met Ala Arg Phe Asp Leu Glu Lys Met 
            260                 265                 270         


Leu Lys Asp Val Glu Lys Tyr Lys Val Thr His Leu Trp Val Val Pro 
        275                 280                 285             


Pro Val Ile Leu Ala Leu Ser Lys Asn Ser Met Val Lys Lys Phe Asn 
    290                 295                 300                 


Leu Ser Ser Ile Lys Tyr Ile Gly Ser Gly Ala Ala Pro Leu Gly Lys 
305                 310                 315                 320 


Asp Leu Met Glu Glu Cys Ser Lys Val Val Pro Tyr Gly Ile Val Ala 
                325                 330                 335     


Gln Gly Tyr Gly Met Thr Glu Thr Cys Gly Ile Val Ser Met Glu Asp 
            340                 345                 350         


Ile Arg Gly Gly Lys Arg Asn Ser Gly Ser Ala Gly Met Leu Ala Ser 
        355                 360                 365             


Gly Val Glu Ala Gln Ile Val Ser Val Asp Thr Leu Lys Pro Leu Pro 
    370                 375                 380                 


Pro Asn Gln Leu Gly Glu Ile Trp Val Lys Gly Pro Asn Met Met Gln 
385                 390                 395                 400 


Gly Tyr Phe Asn Asn Pro Gln Ala Thr Lys Leu Thr Ile Asp Lys Lys 
                405                 410                 415     


Gly Trp Val His Thr Gly Asp Leu Gly Tyr Phe Asp Glu Asp Gly His 
            420                 425                 430         


Leu Tyr Val Val Asp Arg Ile Lys Glu Leu Ile Lys Tyr Lys Gly Phe 
        435                 440                 445             


Gln Val Ala Pro Ala Glu Leu Glu Gly Leu Leu Val Ser His Pro Glu 
    450                 455                 460                 


Ile Leu Asp Ala Val Val Ile Pro Phe Pro Asp Ala Glu Ala Gly Glu 
465                 470                 475                 480 


Val Pro Val Ala Tyr Val Val Arg Ser Pro Asn Ser Ser Leu Thr Glu 
                485                 490                 495     


Asn Asp Val Lys Lys Phe Ile Ala Gly Gln Val Ala Ser Phe Lys Arg 
            500                 505                 510         


Leu Arg Lys Val Thr Phe Ile Asn Ser Val Pro Lys Ser Ala Ser Gly 
        515                 520                 525             


Lys Ile Leu Arg Arg Glu Leu Ile Gln Lys Val Arg Ser Asn Met 
    530                 535                 540             


<210> 3
<211> 720
<212> PRT
<213> Cannabis sativa

<400> 3
Met Gly Lys Asn Tyr Lys Ser Leu Asp Ser Val Val Ala Ser Asp Phe 
1               5                   10                  15      


Ile Ala Leu Gly Ile Thr Ser Glu Val Ala Glu Thr Leu His Gly Arg 
            20                  25                  30          


Leu Ala Glu Ile Val Cys Asn Tyr Gly Ala Ala Thr Pro Gln Thr Trp 
        35                  40                  45              


Ile Asn Ile Ala Asn His Ile Leu Ser Pro Asp Leu Pro Phe Ser Leu 
    50                  55                  60                  


His Gln Met Leu Phe Tyr Gly Cys Tyr Lys Asp Phe Gly Pro Ala Pro 
65                  70                  75                  80  


Pro Ala Trp Ile Pro Asp Pro Glu Lys Val Lys Ser Thr Asn Leu Gly 
                85                  90                  95      


Ala Leu Leu Glu Lys Arg Gly Lys Glu Phe Leu Gly Val Lys Tyr Lys 
            100                 105                 110         


Asp Pro Ile Ser Ser Phe Ser His Phe Gln Glu Phe Ser Val Arg Asn 
        115                 120                 125             


Pro Glu Val Tyr Trp Arg Thr Val Leu Met Asp Glu Met Lys Ile Ser 
    130                 135                 140                 


Phe Ser Lys Asp Pro Glu Cys Ile Leu Arg Arg Asp Asp Ile Asn Asn 
145                 150                 155                 160 


Pro Gly Gly Ser Glu Trp Leu Pro Gly Gly Tyr Leu Asn Ser Ala Lys 
                165                 170                 175     


Asn Cys Leu Asn Val Asn Ser Asn Lys Lys Leu Asn Asp Thr Met Ile 
            180                 185                 190         


Val Trp Arg Asp Glu Gly Asn Asp Asp Leu Pro Leu Asn Lys Leu Thr 
        195                 200                 205             


Leu Asp Gln Leu Arg Lys Arg Val Trp Leu Val Gly Tyr Ala Leu Glu 
    210                 215                 220                 


Glu Met Gly Leu Glu Lys Gly Cys Ala Ile Ala Ile Asp Met Pro Met 
225                 230                 235                 240 


His Val Asp Ala Val Val Ile Tyr Leu Ala Ile Val Leu Ala Gly Tyr 
                245                 250                 255     


Val Val Val Ser Ile Ala Asp Ser Phe Ser Ala Pro Glu Ile Ser Thr 
            260                 265                 270         


Arg Leu Arg Leu Ser Lys Ala Lys Ala Ile Phe Thr Gln Asp His Ile 
        275                 280                 285             


Ile Arg Gly Lys Lys Arg Ile Pro Leu Tyr Ser Arg Val Val Glu Ala 
    290                 295                 300                 


Lys Ser Pro Met Ala Ile Val Ile Pro Cys Ser Gly Ser Asn Ile Gly 
305                 310                 315                 320 


Ala Glu Leu Arg Asp Gly Asp Ile Ser Trp Asp Tyr Phe Leu Glu Arg 
                325                 330                 335     


Ala Lys Glu Phe Lys Asn Cys Glu Phe Thr Ala Arg Glu Gln Pro Val 
            340                 345                 350         


Asp Ala Tyr Thr Asn Ile Leu Phe Ser Ser Gly Thr Thr Gly Glu Pro 
        355                 360                 365             


Lys Ala Ile Pro Trp Thr Gln Ala Thr Pro Leu Lys Ala Ala Ala Asp 
    370                 375                 380                 


Gly Trp Ser His Leu Asp Ile Arg Lys Gly Asp Val Ile Val Trp Pro 
385                 390                 395                 400 


Thr Asn Leu Gly Trp Met Met Gly Pro Trp Leu Val Tyr Ala Ser Leu 
                405                 410                 415     


Leu Asn Gly Ala Ser Ile Ala Leu Tyr Asn Gly Ser Pro Leu Val Ser 
            420                 425                 430         


Gly Phe Ala Lys Phe Val Gln Asp Ala Lys Val Thr Met Leu Gly Val 
        435                 440                 445             


Val Pro Ser Ile Val Arg Ser Trp Lys Ser Thr Asn Cys Val Ser Gly 
    450                 455                 460                 


Tyr Asp Trp Ser Thr Ile Arg Cys Phe Ser Ser Ser Gly Glu Ala Ser 
465                 470                 475                 480 


Asn Val Asp Glu Tyr Leu Trp Leu Met Gly Arg Ala Asn Tyr Lys Pro 
                485                 490                 495     


Val Ile Glu Met Cys Gly Gly Thr Glu Ile Gly Gly Ala Phe Ser Ala 
            500                 505                 510         


Gly Ser Phe Leu Gln Ala Gln Ser Leu Ser Ser Phe Ser Ser Gln Cys 
        515                 520                 525             


Met Gly Cys Thr Leu Tyr Ile Leu Asp Lys Asn Gly Tyr Pro Met Pro 
    530                 535                 540                 


Lys Asn Lys Pro Gly Ile Gly Glu Leu Ala Leu Gly Pro Val Met Phe 
545                 550                 555                 560 


Gly Ala Ser Lys Thr Leu Leu Asn Gly Asn His His Asp Val Tyr Phe 
                565                 570                 575     


Lys Gly Met Pro Thr Leu Asn Gly Glu Val Leu Arg Arg His Gly Asp 
            580                 585                 590         


Ile Phe Glu Leu Thr Ser Asn Gly Tyr Tyr His Ala His Gly Arg Ala 
        595                 600                 605             


Asp Asp Thr Met Asn Ile Gly Gly Ile Lys Ile Ser Ser Ile Glu Ile 
    610                 615                 620                 


Glu Arg Val Cys Asn Glu Val Asp Asp Arg Val Phe Glu Thr Thr Ala 
625                 630                 635                 640 


Ile Gly Val Pro Pro Leu Gly Gly Gly Pro Glu Gln Leu Val Ile Phe 
                645                 650                 655     


Phe Val Leu Lys Asp Ser Asn Asp Thr Thr Ile Asp Leu Asn Gln Leu 
            660                 665                 670         


Arg Leu Ser Phe Asn Leu Gly Leu Gln Lys Lys Leu Asn Pro Leu Phe 
        675                 680                 685             


Lys Val Thr Arg Val Val Pro Leu Ser Ser Leu Pro Arg Thr Ala Thr 
    690                 695                 700                 


Asn Lys Ile Met Arg Arg Val Leu Arg Gln Gln Phe Ser His Phe Glu 
705                 710                 715                 720 


<210> 4
<211> 385
<212> PRT
<213> Cannabis sativa

<400> 4
Met Asn His Leu Arg Ala Glu Gly Pro Ala Ser Val Leu Ala Ile Gly 
1               5                   10                  15      


Thr Ala Asn Pro Glu Asn Ile Leu Leu Gln Asp Glu Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Phe Arg Val Thr Lys Ser Glu His Met Thr Gln Leu Lys Glu Lys 
        35                  40                  45              


Phe Arg Lys Ile Cys Asp Lys Ser Met Ile Arg Lys Arg Asn Cys Phe 
    50                  55                  60                  


Leu Asn Glu Glu His Leu Lys Gln Asn Pro Arg Leu Val Glu His Glu 
65                  70                  75                  80  


Met Gln Thr Leu Asp Ala Arg Gln Asp Met Leu Val Val Glu Val Pro 
                85                  90                  95      


Lys Leu Gly Lys Asp Ala Cys Ala Lys Ala Ile Lys Glu Trp Gly Gln 
            100                 105                 110         


Pro Lys Ser Lys Ile Thr His Leu Ile Phe Thr Ser Ala Ser Thr Thr 
        115                 120                 125             


Asp Met Pro Gly Ala Asp Tyr His Cys Ala Lys Leu Leu Gly Leu Ser 
    130                 135                 140                 


Pro Ser Val Lys Arg Val Met Met Tyr Gln Leu Gly Cys Tyr Gly Gly 
145                 150                 155                 160 


Gly Thr Val Leu Arg Ile Ala Lys Asp Ile Ala Glu Asn Asn Lys Gly 
                165                 170                 175     


Ala Arg Val Leu Ala Val Cys Cys Asp Ile Met Ala Cys Leu Phe Arg 
            180                 185                 190         


Gly Pro Ser Glu Ser Asp Leu Glu Leu Leu Val Gly Gln Ala Ile Phe 
        195                 200                 205             


Gly Asp Gly Ala Ala Ala Val Ile Val Gly Ala Glu Pro Asp Glu Ser 
    210                 215                 220                 


Val Gly Glu Arg Pro Ile Phe Glu Leu Val Ser Thr Gly Gln Thr Ile 
225                 230                 235                 240 


Leu Pro Asn Ser Glu Gly Thr Ile Gly Gly His Ile Arg Glu Ala Gly 
                245                 250                 255     


Leu Ile Phe Asp Leu His Lys Asp Val Pro Met Leu Ile Ser Asn Asn 
            260                 265                 270         


Ile Glu Lys Cys Leu Ile Glu Ala Phe Thr Pro Ile Gly Ile Ser Asp 
        275                 280                 285             


Trp Asn Ser Ile Phe Trp Ile Thr His Pro Gly Gly Lys Ala Ile Leu 
    290                 295                 300                 


Asp Lys Val Glu Glu Lys Leu His Leu Lys Ser Asp Lys Phe Val Asp 
305                 310                 315                 320 


Ser Arg His Val Leu Ser Glu His Gly Asn Met Ser Ser Ser Thr Val 
                325                 330                 335     


Leu Phe Val Met Asp Glu Leu Arg Lys Arg Ser Leu Glu Glu Gly Lys 
            340                 345                 350         


Ser Thr Thr Gly Asp Gly Phe Glu Trp Gly Val Leu Phe Gly Phe Gly 
        355                 360                 365             


Pro Gly Leu Thr Val Glu Arg Val Val Val Arg Ser Val Pro Ile Lys 
    370                 375                 380                 


Tyr 
385 


<210> 5
<211> 101
<212> PRT
<213> Cannabis sativa

<400> 5
Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys 
            100     


<210> 6
<211> 99
<212> PRT
<213> Cannabis sativa

<400> 6
Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr Glu 
1               5                   10                  15      


Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn Ile 
            20                  25                  30          


Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln Lys 
        35                  40                  45              


Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu Ser 
    50                  55                  60                  


Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly Phe 
65                  70                  75                  80  


Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp Tyr 
                85                  90                  95      


Thr Pro Arg 
            


<210> 7
<211> 95
<212> PRT
<213> Cannabis sativa

<400> 7
Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr Glu 
1               5                   10                  15      


Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn Ile 
            20                  25                  30          


Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln Lys 
        35                  40                  45              


Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu Ser 
    50                  55                  60                  


Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly Phe 
65                  70                  75                  80  


Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95  


<210> 8
<211> 415
<212> PRT
<213> Ralstonia solanacearum

<400> 8
Met Ala Phe Asn Glu Arg Val Val Asp Trp Gln Gln Val Ala Gly Ala 
1               5                   10                  15      


Gln Pro Asp Ala Ser Pro Glu Arg Met Ser Ala Asp Asp Pro Phe Met 
            20                  25                  30          


Ile Ile Tyr Thr Ser Gly Thr Thr Gly Lys Pro Lys Gly Thr Val His 
        35                  40                  45              


Thr His Gly Ser Phe Pro Met Lys Ile Ala His Asp Ser Ala Ile His 
    50                  55                  60                  


Phe Asn Val Ser Pro Lys Asp Val Phe Cys Trp Pro Ala Asp Met Gly 
65                  70                  75                  80  


Trp Val Ala Gly Thr Leu Val Met Ser Cys Ala Leu Leu Arg Gly Ala 
                85                  90                  95      


Thr Leu Val Cys Tyr Asp Gly Ala Pro Asp Phe Pro Asp Trp Ser Arg 
            100                 105                 110         


Met Ser Arg Leu Ile Glu Arg His Arg Val Thr His Phe Gly Ser Ala 
        115                 120                 125             


Pro Thr Leu Ile Arg Gly Leu Ala Ser Asn Glu Ala Ile Ala Thr Gln 
    130                 135                 140                 


Gly Asp Val Ser Ser Val Lys Leu Leu Ile Thr Ala Gly Glu Gly Ile 
145                 150                 155                 160 


Asp Pro Glu His Phe Leu Trp Phe Gln Lys Ala Phe Gly Gly Gly His 
                165                 170                 175     


Arg Pro Val Ile Asn Tyr Thr Gly Gly Thr Glu Val Ser Gly Ala Leu 
            180                 185                 190         


Leu Ser Ser Val Val Ile Lys Pro Ile Ser Pro Ala Gly Phe Asn Thr 
        195                 200                 205             


Ala Ser Pro Gly Val Ala Thr Asp Val Val Asp Ala Glu Gly His Ser 
    210                 215                 220                 


Val Thr Gly Glu Val Gly Glu Leu Ala Ile Arg Lys Pro Phe Ile Gly 
225                 230                 235                 240 


Met Thr Arg Ser Phe Trp Gln Asp Asp Glu Arg Tyr Leu Asp Ser Tyr 
                245                 250                 255     


Trp Arg Thr Ile Pro Gly Ile Trp Val His Gly Asp Leu Ala Met Arg 
            260                 265                 270         


Arg Glu Asp Gly Met Trp Phe Met Met Gly Arg Ser Asp Asp Thr Ile 
        275                 280                 285             


Lys Leu Ala Gly Lys Arg Leu Gly Pro Ala Glu Ile Glu Asp Val Leu 
    290                 295                 300                 


Leu Glu Leu Pro Glu Ile Ala Glu Ala Ala Ala Ile Gly Val Glu Asp 
305                 310                 315                 320 


Pro Val Lys Gly Gln Lys Leu Val Val Phe Val Val Ala Ser Lys Ala 
                325                 330                 335     


Ser Thr Ala Ser Ala Asp Ala Leu Ala Ser Val Ile Gly Lys His Val 
            340                 345                 350         


Asp Leu Arg Leu Gly Arg Pro Phe Arg Pro Ser Val Val His Val Val 
        355                 360                 365             


Ala Gln Leu Pro Lys Thr Arg Ser Ser Lys Ile Met Arg Arg Val Ile 
    370                 375                 380                 


Arg Ser Val Tyr Thr Gly Lys Pro Ala Gly Asp Leu Ser Ser Leu Asp 
385                 390                 395                 400 


Asn Pro Leu Ala Leu Asp Glu Ile Arg Ser Ala Ala Ala Val Ser 
                405                 410                 415 


<210> 9
<211> 146
<212> PRT
<213> Streptomyces sp.

<400> 9
Ala Gly Arg Thr Asp Asn Ser Val Val Ile Asp Ala Pro Val Gln Leu 
1               5                   10                  15      


Val Trp Asp Met Thr Asn Asp Val Ser Gln Trp Ala Val Leu Phe Glu 
            20                  25                  30          


Glu Tyr Ala Glu Ser Glu Val Leu Ala Val Asp Gly Asp Thr Val Arg 
        35                  40                  45              


Phe Arg Leu Thr Thr Gln Pro Asp Glu Asp Gly Lys Gln Trp Ser Trp 
    50                  55                  60                  


Val Ser Glu Arg Thr Arg Asp Leu Glu Asn Arg Thr Val Thr Ala Arg 
65                  70                  75                  80  


Arg Leu Asp Asn Gly Leu Phe Glu Tyr Met Asn Ile Arg Trp Glu Tyr 
                85                  90                  95      


Thr Glu Gly Pro Asp Gly Val Arg Met Arg Trp Ile Gln Glu Phe Ser 
            100                 105                 110         


Met Lys Pro Ser Ala Pro Val Asp Asp Ser Gly Ala Glu Asp His Leu 
        115                 120                 125             


Asn Arg Gln Thr Val Lys Glu Met Ala Arg Ile Lys Lys Leu Ile Glu 
    130                 135                 140                 


Glu Ala 
145     


<210> 10
<211> 5
<212> PRT
<213> Cannabis sativa

<400> 10
Tyr Thr Pro Arg Lys 
1               5   


