                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING T 
      CELL-DRIVEN DISEASES

<130> 701039-093810WOPT

<140> PCT/US2019/058114
<141> 2019-10-25

<150> 62/775,099
<151> 2018-12-04

<150> 62/752,738
<151> 2018-10-30

<160> 4     

<170> PatentIn version 3.5

<210> 1
<211> 2433
<212> DNA
<213> Homo sapiens

<400> 1
atgattccgg tgacagagct ccgctacttt gcggacacgc agccagcata ccggatcctg       60

aagccgtggt gggatgtgtt cacagactac atctctatcg tcatgctgat gattgccgtc      120

ttcgggggga cgctgcaggt cacccaagac aagatgatct gcctgccttg taagtgggtc      180

accaaggact cctgcaatga ttcgttccgg ggctgggcag cccctggccc ggagcccacc      240

taccccaact ccaccattct gccgacccct gacacgggcc ccacaggcat caagtatgac      300

ctggaccggc accagtacaa ctacgtggac gctgtgtgct atgagaaccg actgcactgg      360

tttgccaagt acttccccta cctggtgctt ctgcacacgc tcatcttcct ggcctgcagc      420

aacttctggt tcaaattccc gcgcaccagc tcgaagctgg agcactttgt gtctatcctg      480

ctgaagtgct tcgactcgcc ctggaccacg agggccctgt cggagacagt ggtggaggag      540

agcgacccca agccggcctt cagcaagatg aatgggtcca tggacaaaaa gtcatcgacc      600

gtcagtgagg acgtggaggc caccgtgccc atgctgcagc ggaccaagtc acggatcgag      660

cagggtatcg tggaccgctc agagacgggc gtgctggaca agaaggaggg ggagcaagcc      720

aaggcgctgt ttgagaaggt gaagaagttc cggacccatg tggaggaggg ggacattgtg      780

taccgcctct acatgcggca gaccatcatc aaggtgatca agttcatcct catcatctgc      840

tacaccgtct actacgtgca caacatcaag ttcgacgtgg actgcaccgt ggacattgag      900

agcctgacgg gctaccgcac ctaccgctgt gcccaccccc tggccacact cttcaagatc      960

ctggcgtcct tctacatcag cctagtcatc ttctacggcc tcatctgcat gtatacactg     1020

tggtggatgc tacggcgctc cctcaagaag tactcgtttg agtcgatccg tgaggagagc     1080

agctacagcg acatccccga cgtcaagaac gacttcgcct tcatgctgca cctcattgac     1140

caatacgacc cgctctactc caagcgcttc gccgtcttcc tgtcggaggt gagtgagaac     1200

aagctgcggc agctgaacct caacaacgag tggacgctgg acaagctccg gcagcggctc     1260

accaagaacg cgcaggacaa gctggagctg cacctgttca tgctcagtgg catccctgac     1320

actgtgtttg acctggtgga gctggaggtc ctcaagctgg agctgatccc cgacgtgacc     1380

atcccgccca gcattgccca gctcacgggc ctcaaggagc tgtggctcta ccacacagcg     1440

gccaagattg aagcgcccgc gctggccttc ctgcgcgaga acctgcgggc gctgcacatc     1500

aagttcaccg acatcaagga gatcccgctg tggatctata gcctgaagac actggaggag     1560

ctgcacctga cgggcaacct gagcgcggag aacaaccgct acatcgtcat cgacgggctg     1620

cgggagctca aacgcctcaa ggtgctgcgg ctcaagagca acctaagcaa gctgccacag     1680

gtggtcacag atgtgggcgt gcacctgcag aagctgtcca tcaacaatga gggcaccaag     1740

ctcatcgtcc tcaacagcct caagaagatg gcgaacctga ctgagctgga gctgatccgc     1800

tgtgacctgg agcgcatccc ccactccatc ttcagcctcc acaacctgca ggagattgac     1860

ctcaaggaca acaacctcaa gaccatcgag gagatcatca gcttccagca cctgcaccgc     1920

ctcacctgcc ttaagctgtg gtacaaccac atcgcctaca tccccatcca gatcggcaac     1980

ctcaccaacc tggagcgcct ctacctgaac cgcaacaaga tcgagaagat ccccacccag     2040

ctcttctact gccgcaagct gcgctacctg gacctcagcc acaacaacct gaccttcctc     2100

cctgccgaca tcggcctcct gcagaacctc cagaacctag ccatcacggc caaccggatc     2160

gagacgctcc ctccggagct cttccagtgc cggaagctgc gggccctgca cctgggcaac     2220

aacgtgctgc agtcactgcc ctccagggtg ggcgagctga ccaacctgac gcagatcgag     2280

ctgcggggca accggctgga gtgcctgcct gtggagctgg gcgagtgccc actgctcaag     2340

cgcagcggct tggtggtgga ggaggacctg ttcaacacac tgccacccga ggtgaaggag     2400

cggctgtgga gggctgacaa ggagcaggcc tga                                  2433


<210> 2
<211> 810
<212> PRT
<213> Homo sapiens

<400> 2
Met Ile Pro Val Thr Glu Leu Arg Tyr Phe Ala Asp Thr Gln Pro Ala 
1               5                   10                  15      


Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Thr Asp Tyr Ile Ser 
            20                  25                  30          


Ile Val Met Leu Met Ile Ala Val Phe Gly Gly Thr Leu Gln Val Thr 
        35                  40                  45              


Gln Asp Lys Met Ile Cys Leu Pro Cys Lys Trp Val Thr Lys Asp Ser 
    50                  55                  60                  


Cys Asn Asp Ser Phe Arg Gly Trp Ala Ala Pro Gly Pro Glu Pro Thr 
65                  70                  75                  80  


Tyr Pro Asn Ser Thr Ile Leu Pro Thr Pro Asp Thr Gly Pro Thr Gly 
                85                  90                  95      


Ile Lys Tyr Asp Leu Asp Arg His Gln Tyr Asn Tyr Val Asp Ala Val 
            100                 105                 110         


Cys Tyr Glu Asn Arg Leu His Trp Phe Ala Lys Tyr Phe Pro Tyr Leu 
        115                 120                 125             


Val Leu Leu His Thr Leu Ile Phe Leu Ala Cys Ser Asn Phe Trp Phe 
    130                 135                 140                 


Lys Phe Pro Arg Thr Ser Ser Lys Leu Glu His Phe Val Ser Ile Leu 
145                 150                 155                 160 


Leu Lys Cys Phe Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser Glu Thr 
                165                 170                 175     


Val Val Glu Glu Ser Asp Pro Lys Pro Ala Phe Ser Lys Met Asn Gly 
            180                 185                 190         


Ser Met Asp Lys Lys Ser Ser Thr Val Ser Glu Asp Val Glu Ala Thr 
        195                 200                 205             


Val Pro Met Leu Gln Arg Thr Lys Ser Arg Ile Glu Gln Gly Ile Val 
    210                 215                 220                 


Asp Arg Ser Glu Thr Gly Val Leu Asp Lys Lys Glu Gly Glu Gln Ala 
225                 230                 235                 240 


Lys Ala Leu Phe Glu Lys Val Lys Lys Phe Arg Thr His Val Glu Glu 
                245                 250                 255     


Gly Asp Ile Val Tyr Arg Leu Tyr Met Arg Gln Thr Ile Ile Lys Val 
            260                 265                 270         


Ile Lys Phe Ile Leu Ile Ile Cys Tyr Thr Val Tyr Tyr Val His Asn 
        275                 280                 285             


Ile Lys Phe Asp Val Asp Cys Thr Val Asp Ile Glu Ser Leu Thr Gly 
    290                 295                 300                 


Tyr Arg Thr Tyr Arg Cys Ala His Pro Leu Ala Thr Leu Phe Lys Ile 
305                 310                 315                 320 


Leu Ala Ser Phe Tyr Ile Ser Leu Val Ile Phe Tyr Gly Leu Ile Cys 
                325                 330                 335     


Met Tyr Thr Leu Trp Trp Met Leu Arg Arg Ser Leu Lys Lys Tyr Ser 
            340                 345                 350         


Phe Glu Ser Ile Arg Glu Glu Ser Ser Tyr Ser Asp Ile Pro Asp Val 
        355                 360                 365             


Lys Asn Asp Phe Ala Phe Met Leu His Leu Ile Asp Gln Tyr Asp Pro 
    370                 375                 380                 


Leu Tyr Ser Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu Asn 
385                 390                 395                 400 


Lys Leu Arg Gln Leu Asn Leu Asn Asn Glu Trp Thr Leu Asp Lys Leu 
                405                 410                 415     


Arg Gln Arg Leu Thr Lys Asn Ala Gln Asp Lys Leu Glu Leu His Leu 
            420                 425                 430         


Phe Met Leu Ser Gly Ile Pro Asp Thr Val Phe Asp Leu Val Glu Leu 
        435                 440                 445             


Glu Val Leu Lys Leu Glu Leu Ile Pro Asp Val Thr Ile Pro Pro Ser 
    450                 455                 460                 


Ile Ala Gln Leu Thr Gly Leu Lys Glu Leu Trp Leu Tyr His Thr Ala 
465                 470                 475                 480 


Ala Lys Ile Glu Ala Pro Ala Leu Ala Phe Leu Arg Glu Asn Leu Arg 
                485                 490                 495     


Ala Leu His Ile Lys Phe Thr Asp Ile Lys Glu Ile Pro Leu Trp Ile 
            500                 505                 510         


Tyr Ser Leu Lys Thr Leu Glu Glu Leu His Leu Thr Gly Asn Leu Ser 
        515                 520                 525             


Ala Glu Asn Asn Arg Tyr Ile Val Ile Asp Gly Leu Arg Glu Leu Lys 
    530                 535                 540                 


Arg Leu Lys Val Leu Arg Leu Lys Ser Asn Leu Ser Lys Leu Pro Gln 
545                 550                 555                 560 


Val Val Thr Asp Val Gly Val His Leu Gln Lys Leu Ser Ile Asn Asn 
                565                 570                 575     


Glu Gly Thr Lys Leu Ile Val Leu Asn Ser Leu Lys Lys Met Ala Asn 
            580                 585                 590         


Leu Thr Glu Leu Glu Leu Ile Arg Cys Asp Leu Glu Arg Ile Pro His 
        595                 600                 605             


Ser Ile Phe Ser Leu His Asn Leu Gln Glu Ile Asp Leu Lys Asp Asn 
    610                 615                 620                 


Asn Leu Lys Thr Ile Glu Glu Ile Ile Ser Phe Gln His Leu His Arg 
625                 630                 635                 640 


Leu Thr Cys Leu Lys Leu Trp Tyr Asn His Ile Ala Tyr Ile Pro Ile 
                645                 650                 655     


Gln Ile Gly Asn Leu Thr Asn Leu Glu Arg Leu Tyr Leu Asn Arg Asn 
            660                 665                 670         


Lys Ile Glu Lys Ile Pro Thr Gln Leu Phe Tyr Cys Arg Lys Leu Arg 
        675                 680                 685             


Tyr Leu Asp Leu Ser His Asn Asn Leu Thr Phe Leu Pro Ala Asp Ile 
    690                 695                 700                 


Gly Leu Leu Gln Asn Leu Gln Asn Leu Ala Ile Thr Ala Asn Arg Ile 
705                 710                 715                 720 


Glu Thr Leu Pro Pro Glu Leu Phe Gln Cys Arg Lys Leu Arg Ala Leu 
                725                 730                 735     


His Leu Gly Asn Asn Val Leu Gln Ser Leu Pro Ser Arg Val Gly Glu 
            740                 745                 750         


Leu Thr Asn Leu Thr Gln Ile Glu Leu Arg Gly Asn Arg Leu Glu Cys 
        755                 760                 765             


Leu Pro Val Glu Leu Gly Glu Cys Pro Leu Leu Lys Arg Ser Gly Leu 
    770                 775                 780                 


Val Val Glu Glu Asp Leu Phe Asn Thr Leu Pro Pro Glu Val Lys Glu 
785                 790                 795                 800 


Arg Leu Trp Arg Ala Asp Lys Glu Gln Ala 
                805                 810 


<210> 3
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3
Cys Glu Val Lys Glu Arg Leu Trp Arg Ala Asp Lys Glu Gln Ala 
1               5                   10                  15  


<210> 4
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4
Leu Pro Thr Pro Asp Thr Gly Pro Thr Gly Ile Lys Tyr Asp Leu Asp 
1               5                   10                  15      


Arg His 
        


