                         SEQUENCE LISTING

<110>  Syngenta Participations AG
       REYNOLDS, Clarence Michael
 
<120>  Insecticidal Proteins

<130>  81716-WO-REG-ORG-P-1

<150>  62/752,500
<151>  2018-10-30

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  489
<212>  PRT
<213>  Serratia proteamaculans

<400>  1

Met Lys Ile Glu Ser Ser Lys Val Glu Gly Leu Phe Ser Ser Ser Phe 
1               5                   10                  15      


Thr Arg Val Asn Ala Val Pro Leu Pro Ser Asp Thr Leu Pro Gly Val 
            20                  25                  30          


Gly Ile Ile Gly Cys Gly Tyr Asn Pro Phe Leu Ala Tyr Ala Asp Ala 
        35                  40                  45              


Ser Ala Val Leu His Pro Ile Leu Asp Trp Ser Lys Ser Gln Phe Asn 
    50                  55                  60                  


Glu Ile Thr Met Asn Gly Gln Gln Tyr Gln Leu Pro Asp Val Leu Gln 
65                  70                  75                  80  


Ala Val Trp Leu Ser Asn Gln Ser Tyr Ala Ser Val Thr Gly Lys Ser 
                85                  90                  95      


Leu Gln Ser Tyr Leu Thr Glu Leu Ala Asn Ser Ile Lys Val Ser Gly 
            100                 105                 110         


Asn Tyr Gly Phe Phe Ser Ala Ser Ala Thr Asn Glu Phe Ser Asp Ser 
        115                 120                 125             


Ser Leu Arg Lys Ser Glu Asn Glu Phe Ser Arg Cys Gln Gln Ser Phe 
    130                 135                 140                 


Asp Leu Trp Ser Ile Ser Ile Pro Ala Asp Ile Ala Arg Leu Gln Asn 
145                 150                 155                 160 


Tyr Val Ser Asp Asp Phe Ile Lys Leu Ile Asn Ala Ile Asn Pro Glu 
                165                 170                 175     


Ser Lys Asp Ser Ile Ala Thr Val Phe Asn Val Tyr Gly Ser His Val 
            180                 185                 190         


Leu Met Ser Gly Val Met Gly Gly Lys Ala His Val Ser Ala Ser Ala 
        195                 200                 205             


Asn Lys Leu Thr Leu Thr Gln Lys Phe Glu Met Ser Thr Ile Val Gln 
    210                 215                 220                 


Ala Lys Tyr Glu Gln Leu Thr Ser Gln Leu Ser Val Glu Asp Lys Leu 
225                 230                 235                 240 


Lys Tyr Ser Glu Ala Phe Asp Ser Phe Ser Glu Ser Gly Ser Tyr Thr 
                245                 250                 255     


Tyr Asp Ile Leu Gly Gly Ser Pro Ser Leu Gly Ala Leu Val Phe Lys 
            260                 265                 270         


Asn Asn Ser Gln Gly Ser Ser Asp Asp Asn Leu Lys Asn Trp Ile Gln 
        275                 280                 285             


Ser Ile Ser Ser Met Pro Val Leu Thr Lys Phe Ile Asp Gln Thr Ser 
    290                 295                 300                 


Leu Met Pro Val Trp Leu Leu Cys Glu Asp Lys Thr Lys Ala Asp Ala 
305                 310                 315                 320 


Leu Lys Lys Tyr Tyr Asp Asn Thr Trp Ser Lys Ser Gln Met Ala Val 
                325                 330                 335     


Ala Ser Leu Arg Ala Asn Tyr Ile Asp Glu Leu Thr Phe Val Leu Gly 
            340                 345                 350         


Asp Asn Ser Asp Ile Pro Ala Pro Val Gly Tyr Thr Lys Val Pro Ile 
        355                 360                 365             


Asp Leu Asn Ser Asp Ala Gly Gly Lys Tyr Val Tyr Leu Cys Tyr His 
    370                 375                 380                 


Glu Ala Gln Phe Thr Pro Val Asn Gly Lys Gln Pro Ile Val Asp Ile 
385                 390                 395                 400 


Gln Val Leu Tyr Gly Ser Gln Met Pro Ala Pro Gly Tyr Ile Lys Ile 
                405                 410                 415     


Asp Val Asp Leu Asn Ser Gly Ala Gly Gly Glu Phe Val Tyr Leu Ser 
            420                 425                 430         


Tyr Lys Lys Gly Glu Pro Thr Ser Ser Asp Val Ile Asn Lys Ile Thr 
        435                 440                 445             


Ala Val Tyr Gly Lys Asn Glu Tyr Val Pro Thr Pro Tyr Gly Tyr Lys 
    450                 455                 460                 


Gln Ile Ser Gly Asp Leu Asn Ala Gly Ala Gly Gly Asp Phe Val Tyr 
465                 470                 475                 480 


Leu Cys Thr Tyr Gln Gly Gly Thr Glu 
                485                 


<210>  2
<211>  488
<212>  PRT
<213>  Serratia plymuthica

<400>  2

Met Lys Phe Glu Ser Leu Lys Val Glu Asn Leu Phe Ser Ser Ser Leu 
1               5                   10                  15      


Thr Arg Ile Asn Ala Ile Pro Leu Pro Asn Asp Ala Leu Pro Gly Val 
            20                  25                  30          


Gly Ile Ile Gly Cys Gly Tyr Asn Pro Phe Leu Ala Tyr Ala Asp Ser 
        35                  40                  45              


Ser Ala Val Leu His Pro Val Leu Asp Trp Ser Lys Ser Gln Phe His 
    50                  55                  60                  


Thr Val Thr Met Asn Gly Gln Thr Tyr Gln Leu Pro Glu Ile Leu Asn 
65                  70                  75                  80  


Ala Val Trp Leu Ser Asn Gln Thr Tyr Ser Ser Val Ser Gly Lys Ser 
                85                  90                  95      


Leu Gln Ser Tyr Leu Thr Glu Leu Ser Asn Ser Ile Lys Val Ser Gly 
            100                 105                 110         


Asn Tyr Gly Phe Phe Ser Ala Ser Ala Thr Asn Glu Phe Thr Asp Ser 
        115                 120                 125             


Ser Leu Arg Lys Ser Glu Asn Glu Phe Ser Arg Cys Gln Gln Ser Phe 
    130                 135                 140                 


Asp Leu Trp Ser Ile Ser Ala Pro Ala Asp Ile Ala Arg Leu Gln Asn 
145                 150                 155                 160 


Tyr Ile Ser Asp Asp Phe Lys Lys Leu Ile Ser Ser Ile Asp Pro Asn 
                165                 170                 175     


Asn Gln Gln Thr Leu Ala Thr Ile Phe Asn Val Tyr Gly Ser His Ile 
            180                 185                 190         


Leu Met Ser Gly Val Met Gly Gly Lys Ala His Val Ser Ala Ser Ala 
        195                 200                 205             


Asn Lys Leu Thr Leu Thr Gln Lys Phe Glu Met Ser Thr Ile Val Gln 
    210                 215                 220                 


Ala Lys Tyr Glu Gln Leu Thr Ser Gln Leu Ser Ala Glu Asp Lys Leu 
225                 230                 235                 240 


Lys Tyr Ser Glu Ala Phe Glu Ser Phe Ser Glu Ser Gly Ser Tyr Thr 
                245                 250                 255     


Tyr Asp Ile Leu Gly Gly Ser Pro Ser Leu Gly Ala Leu Val Phe Lys 
            260                 265                 270         


Val Asn Asn Gln Asp Ser Asp Asp Asn Leu Arg Lys Trp Ile Asp Ser 
        275                 280                 285             


Ile Ser Thr Met Pro Val Leu Thr Lys Phe Ile Asp Gln Thr Ser Leu 
    290                 295                 300                 


Leu Pro Val Trp Thr Leu Cys Glu Asp Gln Val Lys Ala Asp Ala Leu 
305                 310                 315                 320 


Lys Asn Tyr Tyr Asn Asn Thr Trp Ser Gln Leu Gln Met Ala Val Ala 
                325                 330                 335     


Arg Leu Arg Ala Asn Tyr Ile Asp Glu Val Thr Phe Val Leu Gly Asp 
            340                 345                 350         


Asn Ser Asp Ile Pro Ala Pro Ala Gly Tyr Thr Lys Val Pro Val Asp 
        355                 360                 365             


Leu Asn Ser Gly Ala Gly Gly Lys Phe Ile Tyr Leu Cys Tyr His Glu 
    370                 375                 380                 


Ala Gln Phe Thr Pro Val Asn Ser Lys Gln Ala Ile Val Gly Leu Gln 
385                 390                 395                 400 


Val Leu Tyr Gly Lys Gln Glu Pro Ala Pro Asp Tyr Ser Arg Ile Asn 
                405                 410                 415     


Ile Asp Leu Asn Ser Gly Ala Asn Gly Asp Asp Val Tyr Leu Ser Tyr 
            420                 425                 430         


Lys Lys Gly Asp Ala Thr Ser Lys Glu Val Ile Asn Lys Ile Thr Ala 
        435                 440                 445             


Val Tyr Gly Lys Asp Gln Tyr Val Pro Thr Pro Tyr Gly Tyr Lys Gln 
    450                 455                 460                 


Ile Pro Gly Asp Leu Asn Ser Gly Ala Gly Gly Asp Phe Val Tyr Phe 
465                 470                 475                 480 


Cys Thr Tyr Gln Gly Gly Thr Glu 
                485             


<210>  3
<211>  489
<212>  PRT
<213>  Serratia quinivorans

<400>  3

Met Lys Ile Glu Ser Ser Lys Val Glu Gly Leu Phe Ser Ser Ser Phe 
1               5                   10                  15      


Thr Arg Val Asn Ala Val Pro Leu Pro Ser Asp Thr Leu Pro Gly Val 
            20                  25                  30          


Gly Ile Ile Gly Cys Gly Tyr Asn Pro Phe Leu Ala Tyr Ala Asp Ala 
        35                  40                  45              


Ser Ala Val Leu His Pro Ile Leu Asp Trp Ser Lys Ser Gln Phe His 
    50                  55                  60                  


Glu Ile Thr Met Asn Gly Gln Gln Tyr Gln Leu Pro Asp Val Leu Gln 
65                  70                  75                  80  


Ala Val Trp Leu Ser Asn Gln Ser Tyr Ala Ser Val Thr Gly Lys Ser 
                85                  90                  95      


Leu Gln Ser Tyr Leu Thr Glu Leu Ala Asn Ser Ile Lys Val Ser Gly 
            100                 105                 110         


Asn Tyr Gly Phe Phe Ser Ala Ser Ala Thr Asn Glu Phe Ser Asp Ser 
        115                 120                 125             


Ser Leu Arg Lys Ser Glu Asn Glu Phe Ser Arg Cys Gln Gln Ser Phe 
    130                 135                 140                 


Asp Leu Trp Ser Ile Ser Ile Pro Ala Asp Ile Ala Arg Leu Gln Asn 
145                 150                 155                 160 


Tyr Val Ser Asp Asp Phe Ile Lys Leu Ile Asn Ala Ile Asn Pro Glu 
                165                 170                 175     


Ser Lys Asp Ser Leu Ala Thr Val Phe Asn Val Tyr Gly Ser His Val 
            180                 185                 190         


Leu Met Ser Gly Val Met Gly Gly Lys Ala His Val Ser Ala Ser Ala 
        195                 200                 205             


Asn Lys Leu Thr Leu Thr Gln Lys Phe Glu Met Ser Thr Ile Val Gln 
    210                 215                 220                 


Ala Lys Tyr Glu Gln Leu Thr Ser Gln Leu Ser Val Glu Asp Lys Leu 
225                 230                 235                 240 


Lys Tyr Ser Glu Ala Phe Asp Ser Phe Ser Glu Ser Gly Ser Tyr Thr 
                245                 250                 255     


Tyr Asp Ile Leu Gly Gly Ser Pro Ser Leu Gly Ala Leu Val Phe Lys 
            260                 265                 270         


Ala Asn Ser Gln Gly Ser Ser Asp Asp Asn Leu Lys Ser Trp Ile Gln 
        275                 280                 285             


Ser Ile Ser Ser Met Pro Val Leu Thr Lys Phe Ile Asp Gln Thr Ser 
    290                 295                 300                 


Leu Met Pro Val Trp Leu Leu Cys Glu Asp Lys Thr Lys Ala Asp Ala 
305                 310                 315                 320 


Leu Lys Lys Tyr Tyr Asp Asn Thr Trp Ser Lys Ser Gln Met Ala Val 
                325                 330                 335     


Ala Ser Leu Arg Ala Asn Tyr Ile Asp Glu Leu Thr Phe Val Leu Gly 
            340                 345                 350         


Asp Asn Ser Asp Ile Pro Ala Pro Val Gly Tyr Thr Lys Val Pro Ile 
        355                 360                 365             


Asp Leu Asn Ser Asp Ala Gly Gly Lys Tyr Val Tyr Leu Cys Tyr His 
    370                 375                 380                 


Glu Ala Gln Phe Thr Pro Val Asn Gly Lys Gln Pro Ile Val Asp Ile 
385                 390                 395                 400 


Gln Val Leu Tyr Gly Ser Gln Met Pro Ala Pro Gly Tyr Ile Lys Ile 
                405                 410                 415     


Asp Val Asp Leu Asn Ser Gly Ala Gly Gly Glu Phe Val Tyr Leu Ser 
            420                 425                 430         


Tyr Lys Lys Gly Glu Pro Thr Ser Ser Asp Val Ile Asn Lys Ile Thr 
        435                 440                 445             


Ala Val Tyr Gly Lys Asn Glu Tyr Val Pro Thr Pro Tyr Gly Tyr Lys 
    450                 455                 460                 


Gln Ile Ser Gly Asp Leu Asn Ala Gly Ala Gly Gly Asp Phe Val Tyr 
465                 470                 475                 480 


Leu Cys Thr Tyr Gln Gly Gly Thr Glu 
                485                 


<210>  4
<211>  490
<212>  PRT
<213>  Woodsholea maritima

<400>  4

Met Lys Ser Leu Asp His Val Ala His Gln Asn Leu Leu Asn Glu Pro 
1               5                   10                  15      


Thr His His Lys Ser Asn Thr Lys Ala Ala Leu Met Arg His Gln Glu 
            20                  25                  30          


Asn Leu Val Glu Arg Tyr Leu Pro Gly Val Glu Val Ile Gly Ala Gly 
        35                  40                  45              


Tyr Asn Pro Phe Gly Val Tyr Ala Ser Thr Asp Ser Val Thr Val Gln 
    50                  55                  60                  


Leu Phe Asp Trp Gln Ser Ala Pro Ser Glu Pro Val Ile Phe Asn Pro 
65                  70                  75                  80  


Asp Tyr Ile Ala Pro Lys Ala Val Ser Val Gln Gln Asn Asp Glu Ala 
                85                  90                  95      


Arg Tyr Thr Asn Val Ser Gly Lys Thr Ile Asn Thr Phe Gln Lys Asn 
            100                 105                 110         


Phe Ser Leu Lys Val Thr Val Ala Gly Ser Tyr Asn Leu Phe Ser Gly 
        115                 120                 125             


Ser Val Ser Asn Glu Phe Ser Ser Ser Glu Thr Arg Asn Ala Glu Asn 
    130                 135                 140                 


Glu Phe Ser Arg Ile Gln Gln Ser Ile Arg Val Trp Ser Leu Arg Leu 
145                 150                 155                 160 


Ala Tyr Thr Asp Ser Leu Arg Glu Tyr Leu Lys Ala Asp Val Arg Asp 
                165                 170                 175     


Tyr Ile Asp Ser Ile Gln Ser Asp Ala Gln Ile Glu Ile Leu Phe Asp 
            180                 185                 190         


Arg Tyr Gly Ser His Phe Leu Thr Gly Val Val Met Gly Gly Ala Ala 
        195                 200                 205             


Ile Met Ala Ser Ser Thr Asn Lys Val Gln Val Asp His Thr Tyr Glu 
    210                 215                 220                 


Asn Glu Thr Ile Ala Lys Ala Ser Tyr Glu Ala Leu Thr Gly Gln Ile 
225                 230                 235                 240 


Ser Ala Glu Thr Ala Ala Lys Tyr Arg Gln Ser Met Ser Ser Phe Ser 
                245                 250                 255     


Gln Asn Ser Asp Ile His Lys Ile Val Val Gly Gly Asp Gly Val Ala 
            260                 265                 270         


Gly Ala Lys Val Tyr Ser Gly Asp Lys Ala Asp Phe Asp Ala Trp Ala 
        275                 280                 285             


Asp Thr Val Gly Thr Ser Pro Asp Phe Val Asp Phe Val Ser Ser Val 
    290                 295                 300                 


Pro Met Leu Gly Ile Trp Glu Leu Cys Lys Asp Asp Ala Gln Ala Lys 
305                 310                 315                 320 


Lys Met Glu Asp Tyr Tyr Asn Asn Thr Trp Ala Pro Arg Lys Ser Lys 
                325                 330                 335     


Glu Ala Gln Ile Tyr Ala Asp Tyr Ile Asp Ala Val Glu Val Ile Gln 
            340                 345                 350         


Ser Asn Ser Ser Gly Val Arg Pro Pro Ser Gly Tyr Thr Lys Ile Asp 
        355                 360                 365             


Tyr Asp Leu Asn Lys Gly Ala Gly Gly Asp Tyr Ile Tyr Leu Cys Tyr 
    370                 375                 380                 


His Lys Ala Arg Tyr Ser Ala Tyr Ser Glu Asn Lys Asp Cys Val Ser 
385                 390                 395                 400 


Asp Leu Ile Ile Ile Lys Gly Asn Gly Ala Arg Ala Pro Ser Gly Tyr 
                405                 410                 415     


Thr Lys Ile Asp Val Asp Leu Asn Glu Asp Ala Gly Gly Lys Tyr Leu 
            420                 425                 430         


Tyr Leu Cys Tyr Lys Lys Gln Ser Tyr Asp Asn Val Glu Ala Ile Lys 
        435                 440                 445             


Gly Leu Ala Val Val Gly Gly Asp Asn Ser His Thr Pro Ala Pro Tyr 
    450                 455                 460                 


Gly Tyr Arg Arg Ile Asp Thr Asp Val Asn Glu Gly Ala Gly Gly Glu 
465                 470                 475                 480 


Tyr Ile Tyr Ile Cys Tyr Ser Lys Gly Ala 
                485                 490 


<210>  5
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spro-Sply hybrid insecticidal protein.

<400>  5

Met Lys Ile Glu Ser Ser Lys Val Glu Gly Leu Phe Ser Ser Ser Phe 
1               5                   10                  15      


Thr Arg Val Asn Ala Val Pro Leu Pro Ser Asp Thr Leu Pro Gly Val 
            20                  25                  30          


Gly Ile Ile Gly Cys Gly Tyr Asn Pro Phe Leu Ala Tyr Ala Asp Ala 
        35                  40                  45              


Ser Ala Val Leu His Pro Ile Leu Asp Trp Ser Lys Ser Gln Phe Asn 
    50                  55                  60                  


Glu Ile Thr Met Asn Gly Gln Gln Tyr Gln Leu Pro Asp Val Leu Gln 
65                  70                  75                  80  


Ala Val Trp Leu Ser Asn Gln Ser Tyr Ala Ser Val Thr Gly Lys Ser 
                85                  90                  95      


Leu Gln Ser Tyr Leu Thr Glu Leu Ala Asn Ser Ile Lys Val Ser Gly 
            100                 105                 110         


Asn Tyr Gly Phe Phe Ser Ala Ser Ala Thr Asn Glu Phe Ser Asp Ser 
        115                 120                 125             


Ser Leu Arg Lys Ser Glu Asn Glu Phe Ser Arg Cys Gln Gln Ser Phe 
    130                 135                 140                 


Asp Leu Trp Ser Ile Ser Ile Pro Ala Asp Ile Ala Arg Leu Gln Asn 
145                 150                 155                 160 


Tyr Val Ser Asp Asp Phe Ile Lys Leu Ile Asn Ala Ile Asn Pro Glu 
                165                 170                 175     


Ser Lys Asp Ser Ile Ala Thr Val Phe Asn Val Tyr Gly Ser His Val 
            180                 185                 190         


Leu Met Ser Gly Val Met Gly Gly Lys Ala His Val Ser Ala Ser Ala 
        195                 200                 205             


Asn Lys Leu Thr Leu Thr Gln Lys Phe Glu Met Ser Thr Ile Val Gln 
    210                 215                 220                 


Ala Lys Tyr Glu Gln Leu Thr Ser Gln Leu Ser Val Glu Asp Lys Leu 
225                 230                 235                 240 


Lys Tyr Ser Glu Ala Phe Asp Ser Phe Ser Glu Ser Gly Ser Tyr Thr 
                245                 250                 255     


Tyr Asp Ile Leu Gly Gly Ser Pro Ser Leu Gly Ala Leu Val Phe Lys 
            260                 265                 270         


Asn Asn Ser Gln Gly Ser Ser Asp Asp Asn Leu Lys Asn Trp Ile Gln 
        275                 280                 285             


Ser Ile Ser Ser Met Pro Val Leu Thr Lys Phe Ile Asp Gln Thr Ser 
    290                 295                 300                 


Leu Met Pro Val Trp Leu Leu Cys Glu Asp Lys Thr Lys Ala Asp Ala 
305                 310                 315                 320 


Leu Lys Lys Tyr Tyr Asp Asn Thr Trp Ser Lys Ser Gln Met Ala Val 
                325                 330                 335     


Ala Ser Leu Arg Ala Asn Tyr Ile Asp Glu Val Thr Phe Val Leu Gly 
            340                 345                 350         


Asp Asn Ser Asp Ile Pro Ala Pro Ala Gly Tyr Thr Lys Val Pro Val 
        355                 360                 365             


Asp Leu Asn Ser Gly Ala Gly Gly Lys Phe Ile Tyr Leu Cys Tyr His 
    370                 375                 380                 


Glu Ala Gln Phe Thr Pro Val Asn Ser Lys Gln Ala Ile Val Gly Leu 
385                 390                 395                 400 


Gln Val Leu Tyr Gly Lys Gln Glu Pro Ala Pro Asp Tyr Ser Arg Ile 
                405                 410                 415     


Asn Ile Asp Leu Asn Ser Gly Ala Asn Gly Asp Asp Val Tyr Leu Ser 
            420                 425                 430         


Tyr Lys Lys Gly Asp Ala Thr Ser Lys Glu Val Ile Asn Lys Ile Thr 
        435                 440                 445             


Ala Val Tyr Gly Lys Asp Gln Tyr Val Pro Thr Pro Tyr Gly Tyr Lys 
    450                 455                 460                 


Gln Ile Pro Gly Asp Leu Asn Ser Gly Ala Gly Gly Asp Phe Val Tyr 
465                 470                 475                 480 


Phe Cys Thr Tyr Gln Gly Gly Thr Glu 
                485                 


<210>  6
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sply-Spro hybrid insecticidal protein.

<400>  6

Met Lys Phe Glu Ser Leu Lys Val Glu Asn Leu Phe Ser Ser Ser Leu 
1               5                   10                  15      


Thr Arg Ile Asn Ala Ile Pro Leu Pro Asn Asp Ala Leu Pro Gly Val 
            20                  25                  30          


Gly Ile Ile Gly Cys Gly Tyr Asn Pro Phe Leu Ala Tyr Ala Asp Ser 
        35                  40                  45              


Ser Ala Val Leu His Pro Val Leu Asp Trp Ser Lys Ser Gln Phe His 
    50                  55                  60                  


Thr Val Thr Met Asn Gly Gln Thr Tyr Gln Leu Pro Glu Ile Leu Asn 
65                  70                  75                  80  


Ala Val Trp Leu Ser Asn Gln Thr Tyr Ser Ser Val Ser Gly Lys Ser 
                85                  90                  95      


Leu Gln Ser Tyr Leu Thr Glu Leu Ser Asn Ser Ile Lys Val Ser Gly 
            100                 105                 110         


Asn Tyr Gly Phe Phe Ser Ala Ser Ala Thr Asn Glu Phe Thr Asp Ser 
        115                 120                 125             


Ser Leu Arg Lys Ser Glu Asn Glu Phe Ser Arg Cys Gln Gln Ser Phe 
    130                 135                 140                 


Asp Leu Trp Ser Ile Ser Ala Pro Ala Asp Ile Ala Arg Leu Gln Asn 
145                 150                 155                 160 


Tyr Ile Ser Asp Asp Phe Lys Lys Leu Ile Ser Ser Ile Asp Pro Asn 
                165                 170                 175     


Asn Gln Gln Thr Leu Ala Thr Ile Phe Asn Val Tyr Gly Ser His Ile 
            180                 185                 190         


Leu Met Ser Gly Val Met Gly Gly Lys Ala His Val Ser Ala Ser Ala 
        195                 200                 205             


Asn Lys Leu Thr Leu Thr Gln Lys Phe Glu Met Ser Thr Ile Val Gln 
    210                 215                 220                 


Ala Lys Tyr Glu Gln Leu Thr Ser Gln Leu Ser Ala Glu Asp Lys Leu 
225                 230                 235                 240 


Lys Tyr Ser Glu Ala Phe Glu Ser Phe Ser Glu Ser Gly Ser Tyr Thr 
                245                 250                 255     


Tyr Asp Ile Leu Gly Gly Ser Pro Ser Leu Gly Ala Leu Val Phe Lys 
            260                 265                 270         


Val Asn Asn Gln Asp Ser Asp Asp Asn Leu Arg Lys Trp Ile Asp Ser 
        275                 280                 285             


Ile Ser Thr Met Pro Val Leu Thr Lys Phe Ile Asp Gln Thr Ser Leu 
    290                 295                 300                 


Leu Pro Val Trp Thr Leu Cys Glu Asp Gln Val Lys Ala Asp Ala Leu 
305                 310                 315                 320 


Lys Asn Tyr Tyr Asn Asn Thr Trp Ser Gln Leu Gln Met Ala Val Ala 
                325                 330                 335     


Arg Leu Arg Ala Asn Tyr Ile Asp Glu Leu Thr Phe Val Leu Gly Asp 
            340                 345                 350         


Asn Ser Asp Ile Pro Ala Pro Val Gly Tyr Thr Lys Val Pro Ile Asp 
        355                 360                 365             


Leu Asn Ser Asp Ala Gly Gly Lys Tyr Val Tyr Leu Cys Tyr His Glu 
    370                 375                 380                 


Ala Gln Phe Thr Pro Val Asn Gly Lys Gln Pro Ile Val Asp Ile Gln 
385                 390                 395                 400 


Val Leu Tyr Gly Ser Gln Met Pro Ala Pro Gly Tyr Ile Lys Ile Asp 
                405                 410                 415     


Val Asp Leu Asn Ser Gly Ala Gly Gly Glu Phe Val Tyr Leu Ser Tyr 
            420                 425                 430         


Lys Lys Gly Glu Pro Thr Ser Ser Asp Val Ile Asn Lys Ile Thr Ala 
        435                 440                 445             


Val Tyr Gly Lys Asn Glu Tyr Val Pro Thr Pro Tyr Gly Tyr Lys Gln 
    450                 455                 460                 


Ile Ser Gly Asp Leu Asn Ala Gly Ala Gly Gly Asp Phe Val Tyr Leu 
465                 470                 475                 480 


Cys Thr Tyr Gln Gly Gly Thr Glu 
                485             


<210>  7
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SproCRW-WoodsCRW hybrid protein.

<400>  7

Met Lys Ile Glu Ser Ser Lys Val Glu Gly Leu Phe Ser Ser Ser Phe 
1               5                   10                  15      


Thr Arg Val Asn Ala Val Pro Leu Pro Ser Asp Thr Leu Pro Gly Val 
            20                  25                  30          


Gly Ile Ile Gly Cys Gly Tyr Asn Pro Phe Leu Ala Tyr Ala Asp Ala 
        35                  40                  45              


Ser Ala Val Leu His Pro Ile Leu Asp Trp Ser Lys Ser Gln Phe Asn 
    50                  55                  60                  


Glu Ile Thr Met Asn Gly Gln Gln Tyr Gln Leu Pro Asp Val Leu Gln 
65                  70                  75                  80  


Ala Val Trp Leu Ser Asn Gln Ser Tyr Ala Ser Val Thr Gly Lys Ser 
                85                  90                  95      


Leu Gln Ser Tyr Leu Thr Glu Leu Ala Asn Ser Ile Lys Val Ser Gly 
            100                 105                 110         


Asn Tyr Gly Phe Phe Ser Ala Ser Ala Thr Asn Glu Phe Ser Asp Ser 
        115                 120                 125             


Ser Leu Arg Lys Ser Glu Asn Glu Phe Ser Arg Cys Gln Gln Ser Phe 
    130                 135                 140                 


Asp Leu Trp Ser Ile Ser Ile Pro Ala Asp Ile Ala Arg Leu Gln Asn 
145                 150                 155                 160 


Tyr Val Ser Asp Asp Phe Ile Lys Leu Ile Asn Ala Ile Asn Pro Glu 
                165                 170                 175     


Ser Lys Asp Ser Ile Ala Thr Val Phe Asn Val Tyr Gly Ser His Val 
            180                 185                 190         


Leu Met Ser Gly Val Met Gly Gly Lys Ala His Val Ser Ala Ser Ala 
        195                 200                 205             


Asn Lys Leu Thr Leu Thr Gln Lys Phe Glu Met Ser Thr Ile Val Gln 
    210                 215                 220                 


Ala Lys Tyr Glu Gln Leu Thr Ser Gln Leu Ser Val Glu Asp Lys Leu 
225                 230                 235                 240 


Lys Tyr Ser Glu Ala Phe Asp Ser Phe Ser Glu Ser Gly Ser Tyr Thr 
                245                 250                 255     


Tyr Asp Ile Leu Gly Gly Ser Pro Ser Leu Gly Ala Leu Val Phe Lys 
            260                 265                 270         


Asn Asn Ser Gln Gly Ser Ser Asp Asp Asn Leu Lys Asn Trp Ile Gln 
        275                 280                 285             


Ser Ile Ser Ser Met Pro Val Leu Thr Lys Phe Ile Asp Gln Thr Ser 
    290                 295                 300                 


Leu Met Pro Val Trp Leu Leu Cys Glu Asp Lys Thr Lys Ala Asp Ala 
305                 310                 315                 320 


Leu Lys Lys Tyr Tyr Asp Asn Thr Trp Ser Lys Ser Gln Met Ala Val 
                325                 330                 335     


Ala Ser Leu Arg Ala Asn Tyr Ile Asp Ala Val Glu Val Ile Gln Ser 
            340                 345                 350         


Asn Ser Ser Gly Val Arg Pro Pro Ser Gly Tyr Thr Lys Ile Asp Tyr 
        355                 360                 365             


Asp Leu Asn Lys Gly Ala Gly Gly Asp Tyr Ile Tyr Leu Cys Tyr His 
    370                 375                 380                 


Lys Ala Arg Tyr Ser Ala Tyr Ser Glu Asn Lys Asp Cys Val Ser Asp 
385                 390                 395                 400 


Leu Ile Ile Ile Lys Gly Asn Gly Ala Arg Ala Pro Ser Gly Tyr Thr 
                405                 410                 415     


Lys Ile Asp Val Asp Leu Asn Glu Asp Ala Gly Gly Lys Tyr Leu Tyr 
            420                 425                 430         


Leu Cys Tyr Lys Lys Gln Ser Tyr Asp Asn Val Glu Ala Ile Lys Gly 
        435                 440                 445             


Leu Ala Val Val Gly Gly Asp Asn Ser His Thr Pro Ala Pro Tyr Gly 
    450                 455                 460                 


Tyr Arg Arg Ile Asp Thr Asp Val Asn Glu Gly Ala Gly Gly Glu Tyr 
465                 470                 475                 480 


Ile Tyr Ile Cys Tyr Ser Lys Gly Ala 
                485                 


<210>  8
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WoodsCRW-SproCRW hybrid protein.

<400>  8

Met Lys Ser Leu Asp His Val Ala His Gln Asn Leu Leu Asn Glu Pro 
1               5                   10                  15      


Thr His His Lys Ser Asn Thr Lys Ala Ala Leu Met Arg His Gln Glu 
            20                  25                  30          


Asn Leu Val Glu Arg Tyr Leu Pro Gly Val Glu Val Ile Gly Ala Gly 
        35                  40                  45              


Tyr Asn Pro Phe Gly Val Tyr Ala Ser Thr Asp Ser Val Thr Val Gln 
    50                  55                  60                  


Leu Phe Asp Trp Gln Ser Ala Pro Ser Glu Pro Val Ile Phe Asn Pro 
65                  70                  75                  80  


Asp Tyr Ile Ala Pro Lys Ala Val Ser Val Gln Gln Asn Asp Glu Ala 
                85                  90                  95      


Arg Tyr Thr Asn Val Ser Gly Lys Thr Ile Asn Thr Phe Gln Lys Asn 
            100                 105                 110         


Phe Ser Leu Lys Val Thr Val Ala Gly Ser Tyr Asn Leu Phe Ser Gly 
        115                 120                 125             


Ser Val Ser Asn Glu Phe Ser Ser Ser Glu Thr Arg Asn Ala Glu Asn 
    130                 135                 140                 


Glu Phe Ser Arg Ile Gln Gln Ser Ile Arg Val Trp Ser Leu Arg Leu 
145                 150                 155                 160 


Ala Tyr Thr Asp Ser Leu Arg Glu Tyr Leu Lys Ala Asp Val Arg Asp 
                165                 170                 175     


Tyr Ile Asp Ser Ile Gln Ser Asp Ala Gln Ile Glu Ile Leu Phe Asp 
            180                 185                 190         


Arg Tyr Gly Ser His Phe Leu Thr Gly Val Val Met Gly Gly Ala Ala 
        195                 200                 205             


Ile Met Ala Ser Ser Thr Asn Lys Val Gln Val Asp His Thr Tyr Glu 
    210                 215                 220                 


Asn Glu Thr Ile Ala Lys Ala Ser Tyr Glu Ala Leu Thr Gly Gln Ile 
225                 230                 235                 240 


Ser Ala Glu Thr Ala Ala Lys Tyr Arg Gln Ser Met Ser Ser Phe Ser 
                245                 250                 255     


Gln Asn Ser Asp Ile His Lys Ile Val Val Gly Gly Asp Gly Val Ala 
            260                 265                 270         


Gly Ala Lys Val Tyr Ser Gly Asp Lys Ala Asp Phe Asp Ala Trp Ala 
        275                 280                 285             


Asp Thr Val Gly Thr Ser Pro Asp Phe Val Asp Phe Val Ser Ser Val 
    290                 295                 300                 


Pro Met Leu Gly Ile Trp Glu Leu Cys Lys Asp Asp Ala Gln Ala Lys 
305                 310                 315                 320 


Lys Met Glu Asp Tyr Tyr Asn Asn Thr Trp Ala Pro Arg Lys Ser Lys 
                325                 330                 335     


Glu Ala Gln Ile Tyr Ala Asp Tyr Ile Asp Glu Leu Thr Phe Val Leu 
            340                 345                 350         


Gly Asp Asn Ser Asp Ile Pro Ala Pro Val Gly Tyr Thr Lys Val Pro 
        355                 360                 365             


Ile Asp Leu Asn Ser Asp Ala Gly Gly Lys Tyr Val Tyr Leu Cys Tyr 
    370                 375                 380                 


His Glu Ala Gln Phe Thr Pro Val Asn Gly Lys Gln Pro Ile Val Asp 
385                 390                 395                 400 


Ile Gln Val Leu Tyr Gly Ser Gln Met Pro Ala Pro Gly Tyr Ile Lys 
                405                 410                 415     


Ile Asp Val Asp Leu Asn Ser Gly Ala Gly Gly Glu Phe Val Tyr Leu 
            420                 425                 430         


Ser Tyr Lys Lys Gly Glu Pro Thr Ser Ser Asp Val Ile Asn Lys Ile 
        435                 440                 445             


Thr Ala Val Tyr Gly Lys Asn Glu Tyr Val Pro Thr Pro Tyr Gly Tyr 
    450                 455                 460                 


Lys Gln Ile Ser Gly Asp Leu Asn Ala Gly Ala Gly Gly Asp Phe Val 
465                 470                 475                 480 


Tyr Leu Cys Thr Tyr Gln Gly Gly Thr Glu 
                485                 490 


<210>  9
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SplyCRW-WoodsCRW hybrid protein.

<400>  9

Met Lys Phe Glu Ser Leu Lys Val Glu Asn Leu Phe Ser Ser Ser Leu 
1               5                   10                  15      


Thr Arg Ile Asn Ala Ile Pro Leu Pro Asn Asp Ala Leu Pro Gly Val 
            20                  25                  30          


Gly Ile Ile Gly Cys Gly Tyr Asn Pro Phe Leu Ala Tyr Ala Asp Ser 
        35                  40                  45              


Ser Ala Val Leu His Pro Val Leu Asp Trp Ser Lys Ser Gln Phe His 
    50                  55                  60                  


Thr Val Thr Met Asn Gly Gln Thr Tyr Gln Leu Pro Glu Ile Leu Asn 
65                  70                  75                  80  


Ala Val Trp Leu Ser Asn Gln Thr Tyr Ser Ser Val Ser Gly Lys Ser 
                85                  90                  95      


Leu Gln Ser Tyr Leu Thr Glu Leu Ser Asn Ser Ile Lys Val Ser Gly 
            100                 105                 110         


Asn Tyr Gly Phe Phe Ser Ala Ser Ala Thr Asn Glu Phe Thr Asp Ser 
        115                 120                 125             


Ser Leu Arg Lys Ser Glu Asn Glu Phe Ser Arg Cys Gln Gln Ser Phe 
    130                 135                 140                 


Asp Leu Trp Ser Ile Ser Ala Pro Ala Asp Ile Ala Arg Leu Gln Asn 
145                 150                 155                 160 


Tyr Ile Ser Asp Asp Phe Lys Lys Leu Ile Ser Ser Ile Asp Pro Asn 
                165                 170                 175     


Asn Gln Gln Thr Leu Ala Thr Ile Phe Asn Val Tyr Gly Ser His Ile 
            180                 185                 190         


Leu Met Ser Gly Val Met Gly Gly Lys Ala His Val Ser Ala Ser Ala 
        195                 200                 205             


Asn Lys Leu Thr Leu Thr Gln Lys Phe Glu Met Ser Thr Ile Val Gln 
    210                 215                 220                 


Ala Lys Tyr Glu Gln Leu Thr Ser Gln Leu Ser Ala Glu Asp Lys Leu 
225                 230                 235                 240 


Lys Tyr Ser Glu Ala Phe Glu Ser Phe Ser Glu Ser Gly Ser Tyr Thr 
                245                 250                 255     


Tyr Asp Ile Leu Gly Gly Ser Pro Ser Leu Gly Ala Leu Val Phe Lys 
            260                 265                 270         


Val Asn Asn Gln Asp Ser Asp Asp Asn Leu Arg Lys Trp Ile Asp Ser 
        275                 280                 285             


Ile Ser Thr Met Pro Val Leu Thr Lys Phe Ile Asp Gln Thr Ser Leu 
    290                 295                 300                 


Leu Pro Val Trp Thr Leu Cys Glu Asp Gln Val Lys Ala Asp Ala Leu 
305                 310                 315                 320 


Lys Asn Tyr Tyr Asn Asn Thr Trp Ser Gln Leu Gln Met Ala Val Ala 
                325                 330                 335     


Arg Leu Arg Ala Asn Tyr Ile Asp Ala Val Glu Val Ile Gln Ser Asn 
            340                 345                 350         


Ser Ser Gly Val Arg Pro Pro Ser Gly Tyr Thr Lys Ile Asp Tyr Asp 
        355                 360                 365             


Leu Asn Lys Gly Ala Gly Gly Asp Tyr Ile Tyr Leu Cys Tyr His Lys 
    370                 375                 380                 


Ala Arg Tyr Ser Ala Tyr Ser Glu Asn Lys Asp Cys Val Ser Asp Leu 
385                 390                 395                 400 


Ile Ile Ile Lys Gly Asn Gly Ala Arg Ala Pro Ser Gly Tyr Thr Lys 
                405                 410                 415     


Ile Asp Val Asp Leu Asn Glu Asp Ala Gly Gly Lys Tyr Leu Tyr Leu 
            420                 425                 430         


Cys Tyr Lys Lys Gln Ser Tyr Asp Asn Val Glu Ala Ile Lys Gly Leu 
        435                 440                 445             


Ala Val Val Gly Gly Asp Asn Ser His Thr Pro Ala Pro Tyr Gly Tyr 
    450                 455                 460                 


Arg Arg Ile Asp Thr Asp Val Asn Glu Gly Ala Gly Gly Glu Tyr Ile 
465                 470                 475                 480 


Tyr Ile Cys Tyr Ser Lys Gly Ala 
                485             


<210>  10
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WoodsCRW-SplyCRW hybrid protein.

<400>  10

Met Lys Ser Leu Asp His Val Ala His Gln Asn Leu Leu Asn Glu Pro 
1               5                   10                  15      


Thr His His Lys Ser Asn Thr Lys Ala Ala Leu Met Arg His Gln Glu 
            20                  25                  30          


Asn Leu Val Glu Arg Tyr Leu Pro Gly Val Glu Val Ile Gly Ala Gly 
        35                  40                  45              


Tyr Asn Pro Phe Gly Val Tyr Ala Ser Thr Asp Ser Val Thr Val Gln 
    50                  55                  60                  


Leu Phe Asp Trp Gln Ser Ala Pro Ser Glu Pro Val Ile Phe Asn Pro 
65                  70                  75                  80  


Asp Tyr Ile Ala Pro Lys Ala Val Ser Val Gln Gln Asn Asp Glu Ala 
                85                  90                  95      


Arg Tyr Thr Asn Val Ser Gly Lys Thr Ile Asn Thr Phe Gln Lys Asn 
            100                 105                 110         


Phe Ser Leu Lys Val Thr Val Ala Gly Ser Tyr Asn Leu Phe Ser Gly 
        115                 120                 125             


Ser Val Ser Asn Glu Phe Ser Ser Ser Glu Thr Arg Asn Ala Glu Asn 
    130                 135                 140                 


Glu Phe Ser Arg Ile Gln Gln Ser Ile Arg Val Trp Ser Leu Arg Leu 
145                 150                 155                 160 


Ala Tyr Thr Asp Ser Leu Arg Glu Tyr Leu Lys Ala Asp Val Arg Asp 
                165                 170                 175     


Tyr Ile Asp Ser Ile Gln Ser Asp Ala Gln Ile Glu Ile Leu Phe Asp 
            180                 185                 190         


Arg Tyr Gly Ser His Phe Leu Thr Gly Val Val Met Gly Gly Ala Ala 
        195                 200                 205             


Ile Met Ala Ser Ser Thr Asn Lys Val Gln Val Asp His Thr Tyr Glu 
    210                 215                 220                 


Asn Glu Thr Ile Ala Lys Ala Ser Tyr Glu Ala Leu Thr Gly Gln Ile 
225                 230                 235                 240 


Ser Ala Glu Thr Ala Ala Lys Tyr Arg Gln Ser Met Ser Ser Phe Ser 
                245                 250                 255     


Gln Asn Ser Asp Ile His Lys Ile Val Val Gly Gly Asp Gly Val Ala 
            260                 265                 270         


Gly Ala Lys Val Tyr Ser Gly Asp Lys Ala Asp Phe Asp Ala Trp Ala 
        275                 280                 285             


Asp Thr Val Gly Thr Ser Pro Asp Phe Val Asp Phe Val Ser Ser Val 
    290                 295                 300                 


Pro Met Leu Gly Ile Trp Glu Leu Cys Lys Asp Asp Ala Gln Ala Lys 
305                 310                 315                 320 


Lys Met Glu Asp Tyr Tyr Asn Asn Thr Trp Ala Pro Arg Lys Ser Lys 
                325                 330                 335     


Glu Ala Gln Ile Tyr Ala Asp Tyr Ile Asp Glu Val Thr Phe Val Leu 
            340                 345                 350         


Gly Asp Asn Ser Asp Ile Pro Ala Pro Ala Gly Tyr Thr Lys Val Pro 
        355                 360                 365             


Val Asp Leu Asn Ser Gly Ala Gly Gly Lys Phe Ile Tyr Leu Cys Tyr 
    370                 375                 380                 


His Glu Ala Gln Phe Thr Pro Val Asn Ser Lys Gln Ala Ile Val Gly 
385                 390                 395                 400 


Leu Gln Val Leu Tyr Gly Lys Gln Glu Pro Ala Pro Asp Tyr Ser Arg 
                405                 410                 415     


Ile Asn Ile Asp Leu Asn Ser Gly Ala Asn Gly Asp Asp Val Tyr Leu 
            420                 425                 430         


Ser Tyr Lys Lys Gly Asp Ala Thr Ser Lys Glu Val Ile Asn Lys Ile 
        435                 440                 445             


Thr Ala Val Tyr Gly Lys Asp Gln Tyr Val Pro Thr Pro Tyr Gly Tyr 
    450                 455                 460                 


Lys Gln Ile Pro Gly Asp Leu Asn Ser Gly Ala Gly Gly Asp Phe Val 
465                 470                 475                 480 


Tyr Phe Cys Thr Tyr Gln Gly Gly Thr Glu 
                485                 490 


<210>  11
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SplyNtSproCt E. coli optimized sequence

<400>  11
atgaagttcg aaagccttaa ggtggagaac ctgttttcga gttcactgac ccggatcaat       60

gccattcccc ttcccaatga cgcattacct ggtgttggga ttattgggtg tggatacaac      120

ccttttctgg cctatgcgga ctcatctgct gtcttacatc ctgtgttgga ctggtcaaag      180

agtcaatttc atacggttac tatgaacgga caaacatatc aattgccgga aatccttaat      240

gccgtgtggt taagtaacca aacttactca tcggtctctg gaaaaagtct gcaaagttat      300

ctgaccgagc tttctaattc aatcaaagtt agtggaaatt atggattttt ttccgcgtct      360

gccacgaacg aattcaccga ttcatcctta agaaaatccg aaaatgaatt cagccgttgt      420

cagcagtctt tcgacttatg gtctataagc gcccctgcag atatagcacg cctgcagaat      480

tatataagtg acgattttaa gaagcttatt tcttcgatag atcccaacaa ccagcaaaca      540

ttggctacaa tattcaacgt gtatggatct catatactga tgagcggcgt catgggcgga      600

aaagcccacg tctcggcgag tgcgaataag cttaccttaa ctcagaaatt tgagatgtcc      660

acgattgttc aggcaaaata cgagcagctt acatcacaac tgtcggccga agacaagtta      720

aagtacagcg aggcgttcga atcattctcc gagtccggtt cctacaccta tgatatctta      780

ggaggttcac ccagtctggg agcattggtc ttcaaggtta acaaccagga ttctgacgat      840

aatttacgga agtggatcga ttcgatctcc accatgcctg tgttgacgaa atttatcgat      900

cagaccagtt tattgcctgt ctggacgctt tgcgaagatc aggtgaaagc cgacgccctg      960

aagaactact ataacaacac atggtcgcag ttgcagatgg ccgttgctag attacgggcc     1020

aactacatcg atgaactgac cttcgtcctc ggtgataatt ctgacattcc tgcgccggta     1080

ggttatacga aagtcccgat cgatcttaat tcggatgccg gcggtaaata cgtttatctg     1140

tgctatcacg aagcccagtt taccccggtg aacggcaaac agcccatcgt ggatattcag     1200

gttctgtacg gttctcagat gcctgcgccg gggtatatta agattgatgt agatctgaac     1260

agcggggccg gtggtgaatt tgtgtacctg tcctataaaa aaggggagcc gacatcgtcc     1320

gatgttatta acaaaatcac cgcggtttat ggaaagaatg aatatgtacc gaccccgtat     1380

ggctataaac agatcagcgg cgacctcaac gctggggcgg ggggtgactt cgtttatttg     1440

tgtacttatc aaggggggac cgaataa                                         1467


<210>  12
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SproNtSplyCt E. coli optimized sequence

<400>  12
atgaaaattg agagcagcaa ggtcgaaggc cttttctcct ctagcttcac acgggtgaat       60

gctgtgccgc ttccgagtga caccctgccg ggtgtaggta tcattggttg cggttataat      120

ccgtttctgg cgtatgccga cgctagcgcc gttctgcacc cgattctcga ttggtcaaag      180

tcacaattta atgaaattac catgaatggc cagcagtacc aacttcctga tgtccttcaa      240

gcagtgtggt taagcaacca gtcgtacgcc tctgtgacag gcaaatcgct ccagtcatac      300

cttactgaac tcgcgaactc tatcaaagtc tctggcaatt atggattttt ttcggcctct      360

gccacgaacg aatttagcga ctcgtcactg cgcaaatcag aaaacgaatt ttcacgctgc      420

cagcaaagtt ttgatttatg gtctatttcg atccctgctg atattgcccg cctccagaac      480

tacgtgtcgg atgactttat taaactcatc aatgcaatta atccagagtc caaagattct      540

atcgccaccg tgtttaacgt ctacgggtcc catgttttaa tgtctggtgt aatggggggg      600

aaagcgcacg ttagcgcctc ggctaataag cttaccctga cccagaaatt tgaaatgtcc      660

accattgtac aagctaaata cgaacagctt accagtcagc tgagcgtaga agacaagctg      720

aaatatagtg aagcgttcga ttcgttttcg gagtctggct cgtataccta cgatatcctg      780

ggcggttcgc cgtccttagg ggctttagtt ttcaaaaaca atagtcaggg ctcgtctgac      840

gataacctta agaactggat ccaatctatt agctcgatgc cagtacttac caaattcatc      900

gaccagacaa gcctgatgcc cgtttggctg ttgtgcgagg ataaaaccaa agccgatgcg      960

ctgaaaaaat attacgataa cacctggtcc aagagccaaa tggccgtcgc aagcctgcgc     1020

gcgaactaca ttgacgaggt aacgtttgtt cttggcgata actctgacat ccctgcgcca     1080

gcagggtata ctaaggtacc agtggacctg aattctgggg caggtggtaa attcatttat     1140

ctttgctatc atgaagcgca gtttactccc gtgaactcta agcaagccat agttggcttg     1200

caggtcttgt acgggaaaca agaaccagca cctgattatt cacgtattaa catagatctg     1260

aattctggag caaacgggga tgatgtctac ctttcttata aaaaggggga cgccacttcg     1320

aaagaagtca tcaacaaaat cactgcggtg tacgggaagg atcagtacgt tcccacaccg     1380

tatggctaca agcaaattcc gggggacctg aattcaggtg cgggtggcga ctttgtctat     1440

ttttgtactt atcagggagg aactgaataa                                      1470


<210>  13
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SproNt-WoodsCt E. coli optimized sequence

<400>  13
atgaaaattg agagcagcaa ggtcgaaggc cttttctcct ctagcttcac acgggtgaat       60

gctgtgccgc ttccgagtga caccctgccg ggtgtaggta tcattggttg cggttataat      120

ccgtttctgg cgtatgccga cgctagcgcc gttctgcacc cgattctcga ttggtcaaag      180

tcacaattta atgaaattac catgaatggc cagcagtacc aacttcctga tgtccttcaa      240

gcagtgtggt taagcaacca gtcgtacgcc tctgtgacag gcaaatcgct ccagtcatac      300

cttactgaac tcgcgaactc tatcaaagtc tctggcaatt atggattttt ttcggcctct      360

gccacgaacg aatttagcga ctcgtcactg cgcaaatcag aaaacgaatt ttcacgctgc      420

cagcaaagtt ttgatttatg gtctatttcg atccctgctg atattgcccg cctccagaac      480

tacgtgtcgg atgactttat taaactcatc aatgcaatta atccagagtc caaagattct      540

atcgccaccg tgtttaacgt ctacgggtcc catgttttaa tgtctggtgt aatggggggg      600

aaagcgcacg ttagcgcctc ggctaataag cttaccctga cccagaaatt tgaaatgtcc      660

accattgtac aagctaaata cgaacagctt accagtcagc tgagcgtaga agacaagctg      720

aaatatagtg aagcgttcga ttcgttttcg gagtctggct cgtataccta cgatatcctg      780

ggcggttcgc cgtccttagg ggctttagtt ttcaaaaaca atagtcaggg ctcgtctgac      840

gataacctta agaactggat ccaatctatt agctcgatgc cagtacttac caaattcatc      900

gaccagacaa gcctgatgcc cgtttggctg ttgtgcgagg ataaaaccaa agccgatgcg      960

ctgaaaaaat attacgataa cacctggtcc aagagccaaa tggccgtcgc aagcctgcgc     1020

gcgaactaca tcgatgcagt cgaagtgatc cagagtaatt cttcgggggt tcgccctccc     1080

agtggatata cgaaaattga ttacgacctc aataaaggcg ccggtgggga ttatatctac     1140

ctgtgttatc ataaagcccg ttatagcgct tactcagaaa acaaagattg cgtttctgat     1200

ttaattatta ttaagggaaa cggagcacgc gccccgagcg gttatacgaa aattgatgtg     1260

gatttgaatg aggatgcagg tggaaaatac ctgtatttat gctacaagaa gcaaagttac     1320

gacaatgtgg aagcaatcaa ggggctggcg gtagttggtg gtgacaattc gcatacccct     1380

gctccgtacg gttaccgtcg gattgacacc gatgttaacg agggggccgg aggtgagtac     1440

atttatatct gttactccaa aggggcttaa                                      1470


<210>  14
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WoodsNt-SproCt E. coli optimized sequence:

<400>  14
atgaaaagct tggatcacgt tgctcatcag aacttactga atgaaccgac tcaccataaa       60

agcaatacca aggcggcgct gatgcgtcat caggaaaacc tggttgaacg ctatctgccg      120

ggtgtggagg tgattggggc aggttacaac cctttcggcg tatacgcgtc cactgactca      180

gttactgtgc aactttttga ttggcaaagc gcgccatcag aaccggtcat ttttaacccc      240

gattacattg ctccgaaagc tgtgtcagta caacaaaatg atgaagcccg gtatacgaac      300

gttagcggca aaacaatcaa cacgtttcaa aaaaacttct ccctgaaagt tactgtcgcg      360

ggatcctata acttatttag cggtagcgtc agcaatgaat tcagcagcag cgaaactcgc      420

aatgcagaaa acgaatttag ccgcatccaa cagagcatcc gcgtctggtc tctgcgcctc      480

gcgtacacgg attccctgcg tgaatattta aaagcggacg ttcgcgatta tatcgatagc      540

attcaatcag atgcgcagat tgaaattctg tttgatcgtt acgggtcaca tttccttacc      600

ggcgtggtga tgggtggcgc agcaatcatg gcgtcttcga ccaataaagt acaggtggac      660

cacacatacg agaatgaaac cattgccaag gccagctacg aagccttaac tgggcagatc      720

tctgctgaga ctgcggctaa atatcgccaa agcatgtcgt cgttctccca gaactccgat      780

attcacaaaa ttgtggtcgg cggagacgga gtcgcgggcg cgaaagtgta tagcggtgac      840

aaggcggatt tcgatgcttg ggctgacacc gtggggacgt ctccagattt tgtggacttt      900

gttagcagcg ttcctatgtt gggaatttgg gaactgtgca aagatgacgc gcaggcgaaa      960

aagatggaag attactataa taatacgtgg gccccgcgga aaagcaaaga ggctcaaatt     1020

tatgctgatt acatcgatga actgaccttc gtcctcggtg ataattctga cattcctgcg     1080

ccggtaggtt atacgaaagt cccgatcgat cttaattcgg atgccggcgg taaatacgtt     1140

tatctgtgct atcacgaagc ccagtttacc ccggtgaacg gcaaacagcc catcgtggat     1200

attcaggttc tgtacggttc tcagatgcct gcgccggggt atattaagat tgatgtagat     1260

ctgaacagcg gggccggtgg tgaatttgtg tacctgtcct ataaaaaagg ggagccgaca     1320

tcgtccgatg ttattaacaa aatcaccgct gtttatggaa agaatgaata tgtaccgacc     1380

ccgtatggct ataaacagat cagcggcgac ctcaacgctg gggcgggggg tgacttcgtt     1440

tatttgtgta cttatcaagg ggggaccgaa taa                                  1473


<210>  15
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SplyNt-WoodsCt E. coli optimized sequence:

<400>  15
atgaagttcg aaagccttaa ggtggagaac ctgttttcga gttcactgac ccggatcaat       60

gccattcccc ttcccaatga cgcattacct ggtgttggga ttattgggtg tggatacaac      120

ccttttctgg cctatgcgga ctcatctgct gtcttacatc ctgtgttgga ctggtcaaag      180

agtcaatttc atacggttac tatgaacgga caaacatatc aattgccgga aatccttaat      240

gccgtgtggt taagtaacca aacttactca tcggtctctg gaaaaagtct gcaaagttat      300

ctgaccgagc tttctaattc aatcaaagtt agtggaaatt atggattttt ttccgcgtct      360

gccacgaacg aattcaccga ttcatcctta agaaaatccg aaaatgaatt cagccgttgt      420

cagcagtctt tcgacttatg gtctataagc gcccctgcag atatagcacg cctgcagaat      480

tatataagtg acgattttaa gaagcttatt tcttcgatag atcccaacaa ccagcaaaca      540

ttggctacaa tattcaacgt gtatggatct catatactga tgagcggcgt catgggcgga      600

aaagcccacg tctcggcgag tgcgaataag cttaccttaa ctcagaaatt tgagatgtcc      660

acgattgttc aggcaaaata cgagcagctt acatcacaac tgtcggccga agacaagtta      720

aagtacagcg aggcgttcga atcattctcc gagtccggtt cctacaccta tgatatctta      780

ggaggttcac ccagtctggg agcattggtc ttcaaggtta acaaccagga ttctgacgat      840

aatttacgga agtggatcga ttcgatctcc accatgcctg tgttgacgaa atttatcgat      900

cagaccagtt tattgcctgt ctggacgctt tgcgaagatc aggtgaaagc cgacgccctg      960

aagaactact ataacaacac atggtcgcag ttgcagatgg ccgttgctag attacgggcc     1020

aactacattg acgcagtcga agtgatccag agtaattctt cgggggttcg ccctcccagt     1080

ggatatacga aaattgatta cgacctcaat aaaggcgccg gtggggatta tatctacctg     1140

tgttatcata aagcccgtta tagcgcttac tcagaaaaca aagattgcgt ttctgattta     1200

attattatta agggaaacgg agcacgcgcc ccgagcggtt atacgaaaat tgatgtggat     1260

ttgaatgagg atgcaggtgg aaaatacctg tatttatgct acaagaagca aagttacgac     1320

aatgtggaag caatcaaggg gctggcggta gttggtggtg acaattcgca tacccctgct     1380

ccgtacggtt accgtcggat tgacaccgat gttaacgagg gggccggagg tgagtacatt     1440

tatatctgtt actccaaagg ggcttaa                                         1467


<210>  16
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WoodsNt-SplyCt E. coli optimized sequence:

<400>  16
atgaaaagct tggatcacgt tgctcatcag aacttactga atgaaccgac tcaccataaa       60

agcaatacca aggcggcgct gatgcgtcat caggaaaacc tggttgaacg ctatctgccg      120

ggtgtggagg tgattggggc aggttacaac cctttcggcg tatacgcgtc cactgactca      180

gttactgtgc aactttttga ttggcaaagc gcgccatcag aaccggtcat ttttaacccc      240

gattacattg ctccgaaagc tgtgtcagta caacaaaatg atgaagcccg gtatacgaac      300

gttagcggca aaacaatcaa cacgtttcaa aaaaacttct ccctgaaagt tactgtcgcg      360

ggatcctata acttatttag cggtagcgtc agcaatgaat tcagcagcag cgaaactcgc      420

aatgcagaaa acgaatttag ccgcatccaa cagagcatcc gcgtctggtc tctgcgcctc      480

gcgtacacgg attccctgcg tgaatattta aaagcggacg ttcgcgatta tatcgatagc      540

attcaatcag atgcgcagat tgaaattctg tttgatcgtt acgggtcaca tttccttacc      600

ggcgtggtga tgggtggcgc agcaatcatg gcgtcttcga ccaataaagt acaggtggac      660

cacacatacg agaatgaaac cattgccaag gccagctacg aagccttaac tgggcagatc      720

tctgctgaga ctgcggctaa atatcgccaa agcatgtcgt cgttctccca gaactccgat      780

attcacaaaa ttgtggtcgg cggagacgga gtcgcgggcg cgaaagtgta tagcggtgac      840

aaggcggatt tcgatgcttg ggctgacacc gtggggacgt ctccagattt tgtggacttt      900

gttagcagcg ttcctatgtt gggaatttgg gaactgtgca aagatgacgc gcaggcgaaa      960

aagatggaag attactataa taatacgtgg gccccgcgga aaagcaaaga ggctcaaatt     1020

tatgctgatt atatcgacga ggtaacgttt gttcttggcg ataactctga catccctgcg     1080

ccagcagggt atactaaggt accagtggac ctgaattctg gggcaggtgg taaattcatt     1140

tatctttgct atcatgaagc gcagtttact cccgtgaact ctaagcaagc catagttggc     1200

ttgcaggtct tgtacgggaa acaagaacca gcacctgatt attcacgtat taacatagat     1260

ctgaattctg gagcaaacgg ggatgatgtc tacctttctt ataaaaaggg ggacgccact     1320

tcgaaagaag tcatcaacaa aatcactgcg gtgtacggga aggatcagta cgttcccaca     1380

ccgtatggct acaagcaaat tccgggggac ctgaattcag gtgcgggtgg cgactttgtc     1440

tatttttgta cttatcaggg aggaactgaa taa                                  1473


<210>  17
<211>  510
<212>  PRT
<213>  Photrhabdus luminescens

<400>  17

Met Ser Asn Asp Lys Thr Gly Lys Ser Leu Glu Gln Glu Asn Ser Glu 
1               5                   10                  15      


Arg Asp Val Glu Ile Arg Asp Arg Asn Tyr Phe Arg Lys Leu Ser Leu 
            20                  25                  30          


Phe Asp Asp Thr Val Ile Ala Gly Ala Glu Met Ile Gly Thr Ser Tyr 
        35                  40                  45              


Asp Val Phe Gly Lys Tyr Cys Asn Val Gly Ser Cys Met Asn Ser Leu 
    50                  55                  60                  


Phe Asp Glu Arg Lys Ile Asn Ala Ser Glu Asp Asn Phe Lys Lys Val 
65                  70                  75                  80  


Thr Ile Leu Gly Lys Thr Leu Lys Val Pro Tyr Tyr Ile Asp Cys Tyr 
                85                  90                  95      


Ser Val Gly Asp Leu Lys Tyr Thr Asn Ala Ser Gly Glu Ser Ile Glu 
            100                 105                 110         


Ser Tyr Gln Ser Asn Ile Ser Ser Lys Ser Arg Ile Lys Gly Asn Tyr 
        115                 120                 125             


Leu Phe Phe Ser Ala Ser Leu Lys Val Asp Phe Asp Thr Asp Ser Leu 
    130                 135                 140                 


Thr Asp Phe Glu Asn Ala Phe Ser Arg Ile Gln Tyr Thr Tyr Asp Leu 
145                 150                 155                 160 


Tyr Ile Leu Lys Ser Ser Ala Glu Ala Leu Lys Glu Phe Leu Lys Glu 
                165                 170                 175     


Ser Val Lys Thr Ala Leu Asp Lys Ala Asp Thr Glu Glu Asp Met Asn 
            180                 185                 190         


Asp Leu Phe Asn Thr Trp Gly Ser His Phe Leu Ser Gly Val Val Met 
        195                 200                 205             


Gly Gly Cys Ala Gln Tyr Ser Ser Ser Thr Asn Lys Tyr Thr Ser Asn 
    210                 215                 220                 


Leu Thr Asn Ser Phe Asp Val Val Ala Ala Ala Ser Phe Ala Gly Phe 
225                 230                 235                 240 


Ile Gly Leu Ser Ala Arg Thr Gly Asn Ser Phe Met Glu Asp Ile Lys 
                245                 250                 255     


Lys Phe Arg Ser Ala Ser Asn Ile Lys Thr His Ala Ile Gly Gly Asp 
            260                 265                 270         


Leu Ser Arg Phe Asp Pro Phe Gly Gly Ala Thr Ser Ala Asp Gln Pro 
        275                 280                 285             


Ser Ala Glu Glu Ile Ala Ala Ala Lys Lys Ala Phe Glu Asp Trp Lys 
    290                 295                 300                 


Ala Ser Val Pro Asn Ala Pro Glu Leu Val Asn Phe Ala Asp Ser Asn 
305                 310                 315                 320 


Pro Leu Thr Gly Ile Trp Glu Leu Cys Ser Asp Arg Thr Gln Lys Ala 
                325                 330                 335     


Lys Leu Lys Lys His Phe Glu Thr Val Trp Ala Pro Ala Glu Ser Ala 
            340                 345                 350         


Lys Arg Arg Val His Ala Asp Tyr Ile Asp Glu Ile Ile Ile Gly Ile 
        355                 360                 365             


Asn Asn Thr Asn Thr Pro Pro Glu Gly Tyr Ile Gly Leu Lys Ser Thr 
    370                 375                 380                 


Lys Asp Glu Asn Leu Asn Ser Lys Gly Asn Ile Cys Leu Phe Met His 
385                 390                 395                 400 


Lys Ala Lys Tyr Asp Pro Asn Ile Asp Asn Lys Asp Cys Ile Thr Glu 
                405                 410                 415     


Leu Lys Phe Ile Thr Val Arg Asp Lys Ser Pro Glu Gly Asp Trp Val 
            420                 425                 430         


Lys Ile Pro Gln Asp Ile Tyr Ile Ser Pro Asn Gln Tyr Leu Tyr Leu 
        435                 440                 445             


Cys Tyr Leu Pro Ala Lys Tyr Ser Ala Glu Lys Ala Ile Lys Asp Ile 
    450                 455                 460                 


Gln Leu Leu Cys Ser Ser Cys Gly Ser Ser Met Ile Leu Pro Tyr Gly 
465                 470                 475                 480 


Tyr Asn Asp Val Leu Asp Glu Arg Gly Glu Arg Ala Asn Ala Thr Glu 
                485                 490                 495     


Asp Asp Asn Val His Tyr Leu Ile Tyr Ser Ala Gly Trp Lys 
            500                 505                 510 


<210>  18
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Plu1415/SproCRW.

<400>  18

Met Ser Asn Asp Lys Thr Gly Lys Ser Leu Glu Gln Glu Asn Ser Glu 
1               5                   10                  15      


Arg Asp Val Glu Ile Arg Asp Arg Asn Tyr Phe Arg Lys Leu Ser Leu 
            20                  25                  30          


Phe Asp Asp Thr Val Ile Ala Gly Ala Glu Met Ile Gly Thr Ser Tyr 
        35                  40                  45              


Asp Val Phe Gly Lys Tyr Cys Asn Val Gly Ser Cys Met Asn Ser Leu 
    50                  55                  60                  


Phe Asp Glu Arg Lys Ile Asn Ala Ser Glu Asp Asn Phe Lys Lys Val 
65                  70                  75                  80  


Thr Ile Leu Gly Lys Thr Leu Lys Val Pro Tyr Tyr Ile Asp Cys Tyr 
                85                  90                  95      


Ser Val Gly Asp Leu Lys Tyr Thr Asn Ala Ser Gly Glu Ser Ile Glu 
            100                 105                 110         


Ser Tyr Gln Ser Asn Ile Ser Ser Lys Ser Arg Ile Lys Gly Asn Tyr 
        115                 120                 125             


Leu Phe Phe Ser Ala Ser Leu Lys Val Asp Phe Asp Thr Asp Ser Leu 
    130                 135                 140                 


Thr Asp Phe Glu Asn Ala Phe Ser Arg Ile Gln Tyr Thr Tyr Asp Leu 
145                 150                 155                 160 


Tyr Ile Leu Lys Ser Ser Ala Glu Ala Leu Lys Glu Phe Leu Lys Glu 
                165                 170                 175     


Ser Val Lys Thr Ala Leu Asp Lys Ala Asp Thr Glu Glu Asp Met Asn 
            180                 185                 190         


Asp Leu Phe Asn Thr Trp Gly Ser His Phe Leu Ser Gly Val Val Met 
        195                 200                 205             


Gly Gly Cys Ala Gln Tyr Ser Ser Ser Thr Asn Lys Tyr Thr Ser Asn 
    210                 215                 220                 


Leu Thr Asn Ser Phe Asp Val Val Ala Ala Ala Ser Phe Ala Gly Phe 
225                 230                 235                 240 


Ile Gly Leu Ser Ala Arg Thr Gly Asn Ser Phe Met Glu Asp Ile Lys 
                245                 250                 255     


Lys Phe Arg Ser Ala Ser Asn Ile Lys Thr His Ala Ile Gly Gly Asp 
            260                 265                 270         


Leu Ser Arg Phe Asp Pro Phe Gly Gly Ala Thr Ser Ala Asp Gln Pro 
        275                 280                 285             


Ser Ala Glu Glu Ile Ala Ala Ala Lys Lys Ala Phe Glu Asp Trp Lys 
    290                 295                 300                 


Ala Ser Val Pro Asn Ala Pro Glu Leu Val Asn Phe Ala Asp Ser Asn 
305                 310                 315                 320 


Pro Leu Thr Gly Ile Trp Glu Leu Cys Ser Asp Arg Thr Gln Lys Ala 
                325                 330                 335     


Lys Leu Lys Lys His Phe Glu Thr Val Trp Ala Pro Ala Glu Ser Ala 
            340                 345                 350         


Lys Arg Arg Val His Ala Asp Tyr Ile Asp Glu Leu Thr Phe Val Leu 
        355                 360                 365             


Gly Asp Asn Ser Asp Ile Pro Ala Pro Val Gly Tyr Thr Lys Val Pro 
    370                 375                 380                 


Ile Asp Leu Asn Ser Asp Ala Gly Gly Lys Tyr Val Tyr Leu Cys Tyr 
385                 390                 395                 400 


His Glu Ala Gln Phe Thr Pro Val Asn Gly Lys Gln Pro Ile Val Asp 
                405                 410                 415     


Ile Gln Val Leu Tyr Gly Ser Gln Met Pro Ala Pro Gly Tyr Ile Lys 
            420                 425                 430         


Ile Asp Val Asp Leu Asn Ser Gly Ala Gly Gly Glu Phe Val Tyr Leu 
        435                 440                 445             


Ser Tyr Lys Lys Gly Glu Pro Thr Ser Ser Asp Val Ile Asn Lys Ile 
    450                 455                 460                 


Thr Ala Val Tyr Gly Lys Asn Glu Tyr Val Pro Thr Pro Tyr Gly Tyr 
465                 470                 475                 480 


Lys Gln Ile Ser Gly Asp Leu Asn Ala Gly Ala Gly Gly Asp Phe Val 
                485                 490                 495     


Tyr Leu Cys Thr Tyr Gln Gly Gly Thr Glu 
            500                 505     


<210>  19
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Plu1415/SplyCRW.

<400>  19

Met Ser Asn Asp Lys Thr Gly Lys Ser Leu Glu Gln Glu Asn Ser Glu 
1               5                   10                  15      


Arg Asp Val Glu Ile Arg Asp Arg Asn Tyr Phe Arg Lys Leu Ser Leu 
            20                  25                  30          


Phe Asp Asp Thr Val Ile Ala Gly Ala Glu Met Ile Gly Thr Ser Tyr 
        35                  40                  45              


Asp Val Phe Gly Lys Tyr Cys Asn Val Gly Ser Cys Met Asn Ser Leu 
    50                  55                  60                  


Phe Asp Glu Arg Lys Ile Asn Ala Ser Glu Asp Asn Phe Lys Lys Val 
65                  70                  75                  80  


Thr Ile Leu Gly Lys Thr Leu Lys Val Pro Tyr Tyr Ile Asp Cys Tyr 
                85                  90                  95      


Ser Val Gly Asp Leu Lys Tyr Thr Asn Ala Ser Gly Glu Ser Ile Glu 
            100                 105                 110         


Ser Tyr Gln Ser Asn Ile Ser Ser Lys Ser Arg Ile Lys Gly Asn Tyr 
        115                 120                 125             


Leu Phe Phe Ser Ala Ser Leu Lys Val Asp Phe Asp Thr Asp Ser Leu 
    130                 135                 140                 


Thr Asp Phe Glu Asn Ala Phe Ser Arg Ile Gln Tyr Thr Tyr Asp Leu 
145                 150                 155                 160 


Tyr Ile Leu Lys Ser Ser Ala Glu Ala Leu Lys Glu Phe Leu Lys Glu 
                165                 170                 175     


Ser Val Lys Thr Ala Leu Asp Lys Ala Asp Thr Glu Glu Asp Met Asn 
            180                 185                 190         


Asp Leu Phe Asn Thr Trp Gly Ser His Phe Leu Ser Gly Val Val Met 
        195                 200                 205             


Gly Gly Cys Ala Gln Tyr Ser Ser Ser Thr Asn Lys Tyr Thr Ser Asn 
    210                 215                 220                 


Leu Thr Asn Ser Phe Asp Val Val Ala Ala Ala Ser Phe Ala Gly Phe 
225                 230                 235                 240 


Ile Gly Leu Ser Ala Arg Thr Gly Asn Ser Phe Met Glu Asp Ile Lys 
                245                 250                 255     


Lys Phe Arg Ser Ala Ser Asn Ile Lys Thr His Ala Ile Gly Gly Asp 
            260                 265                 270         


Leu Ser Arg Phe Asp Pro Phe Gly Gly Ala Thr Ser Ala Asp Gln Pro 
        275                 280                 285             


Ser Ala Glu Glu Ile Ala Ala Ala Lys Lys Ala Phe Glu Asp Trp Lys 
    290                 295                 300                 


Ala Ser Val Pro Asn Ala Pro Glu Leu Val Asn Phe Ala Asp Ser Asn 
305                 310                 315                 320 


Pro Leu Thr Gly Ile Trp Glu Leu Cys Ser Asp Arg Thr Gln Lys Ala 
                325                 330                 335     


Lys Leu Lys Lys His Phe Glu Thr Val Trp Ala Pro Ala Glu Ser Ala 
            340                 345                 350         


Lys Arg Arg Val His Ala Asp Tyr Ile Asp Glu Val Thr Phe Val Leu 
        355                 360                 365             


Gly Asp Asn Ser Asp Ile Pro Ala Pro Ala Gly Tyr Thr Lys Val Pro 
    370                 375                 380                 


Val Asp Leu Asn Ser Gly Ala Gly Gly Lys Phe Ile Tyr Leu Cys Tyr 
385                 390                 395                 400 


His Glu Ala Gln Phe Thr Pro Val Asn Ser Lys Gln Ala Ile Val Gly 
                405                 410                 415     


Leu Gln Val Leu Tyr Gly Lys Gln Glu Pro Ala Pro Asp Tyr Ser Arg 
            420                 425                 430         


Ile Asn Ile Asp Leu Asn Ser Gly Ala Asn Gly Asp Asp Val Tyr Leu 
        435                 440                 445             


Ser Tyr Lys Lys Gly Asp Ala Thr Ser Lys Glu Val Ile Asn Lys Ile 
    450                 455                 460                 


Thr Ala Val Tyr Gly Lys Asp Gln Tyr Val Pro Thr Pro Tyr Gly Tyr 
465                 470                 475                 480 


Lys Gln Ile Pro Gly Asp Leu Asn Ser Gly Ala Gly Gly Asp Phe Val 
                485                 490                 495     


Tyr Phe Cys Thr Tyr Gln Gly Gly Thr Glu 
            500                 505     


<210>  20
<211>  1521
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric Plu1415/SproCRW CDS.

<400>  20
atgtcaaacg ataaaacggg aaaaagtctg gaacaggaaa atagcgagcg cgacgttgaa       60

attcgcgatc gcaactactt tcgcaaattg agcttgtttg acgatactgt tatcgccggt      120

gcggagatga tcggtactag ctacgatgtg tttggcaagt actgcaatgt aggaagctgc      180

atgaacagcc tcttcgatga acgtaaaatc aacgcgagtg aagacaactt taaaaaagtt      240

accattttag gcaaaacgct caaggtaccg tattatatcg attgttattc tgtcggtgat      300

cttaaataca cgaacgcatc aggcgaatct atcgagagtt atcagtctaa catttcttct      360

aaaagtcgta tcaaaggtaa ctatctgttt ttttctgcct cactcaaggt cgatttcgat      420

acggatagcc tgacggattt cgagaatgcc ttctctcgta tccagtacac gtatgatttg      480

tatattttaa aatcatccgc ggaagccctc aaggaatttc tgaaagagtc agtcaaaacg      540

gcgttggaca aggcggatac cgaagaagac atgaacgacc tgtttaatac ttggggcagt      600

catttcctgt caggcgtagt gatgggtggt tgcgcgcaat acagttcgag tacgaataag      660

tatacctcaa atctgaccaa tagctttgac gttgttgcag cggcatcttt cgctggtttt      720

attggtctgt ccgcccgtac aggcaactca tttatggaag atattaaaaa atttcgctcc      780

gcatctaata ttaagaccca cgcgatcggt ggggatctca gccgcttcga tccgttcggc      840

ggcgccacct ccgccgatca accgtctgcc gaagagatcg cggcggccaa gaaggccttt      900

gaagattgga aagccagcgt accaaacgca ccggaattag tgaacttcgc ggattctaat      960

ccgctgaccg gcatttggga gctgtgctcg gatcgtacgc agaaagcgaa actgaaaaaa     1020

cacttcgaga cggtgtgggc cccggcagaa agcgcgaagc gtcgggtaca tgcggattat     1080

atcgacgaac tgaccttcgt cctcggtgat aattctgaca ttcctgcgcc ggtaggttat     1140

acgaaagtcc cgatcgatct taattcggat gccggcggta aatacgttta tctgtgctat     1200

cacgaagccc agtttacccc ggtgaacggc aaacagccca tcgtggatat tcaggttctg     1260

tacggttctc agatgcctgc gccggggtat attaagattg atgtagatct gaacagcggg     1320

gccggtggtg aatttgtgta cctgtcctat aaaaaagggg agccgacatc gtccgatgtt     1380

attaacaaaa tcaccgctgt ttatggaaag aatgaatatg taccgacccc gtatggctat     1440

aaacagatca gcggcgacct caacgctggg gcggggggtg acttcgttta tttgtgtact     1500

tatcaagggg ggaccgaata a                                               1521


<210>  21
<211>  1521
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric Plu1415/SplyCRW CDS.

<400>  21
atgtcaaacg ataaaacggg aaaaagtctg gaacaggaaa atagcgagcg cgacgttgaa       60

attcgcgatc gcaactactt tcgcaaattg agcttgtttg acgatactgt tatcgccggt      120

gcggagatga tcggtactag ctacgatgtg tttggcaagt actgcaatgt aggaagctgc      180

atgaacagcc tcttcgatga acgtaaaatc aacgcgagtg aagacaactt taaaaaagtt      240

accattttag gcaaaacgct caaggtaccg tattatatcg attgttattc tgtcggtgat      300

cttaaataca cgaacgcatc aggcgaatct atcgagagtt atcagtctaa catttcttct      360

aaaagtcgta tcaaaggtaa ctatctgttt ttttctgcct cactcaaggt cgatttcgat      420

acggatagcc tgacggattt cgagaatgcc ttctctcgta tccagtacac gtatgatttg      480

tatattttaa aatcatccgc ggaagccctc aaggaatttc tgaaagagtc agtcaaaacg      540

gcgttggaca aggcggatac cgaagaagac atgaacgacc tgtttaatac ttggggcagt      600

catttcctgt caggcgtagt gatgggtggt tgcgcgcaat acagttcgag tacgaataag      660

tatacctcaa atctgaccaa tagctttgac gttgttgcag cggcatcttt cgctggtttt      720

attggtctgt ccgcccgtac aggcaactca tttatggaag atattaaaaa atttcgctcc      780

gcatctaata ttaagaccca cgcgatcggt ggggatctca gccgcttcga tccgttcggc      840

ggcgccacct ccgccgatca accgtctgcc gaagagatcg cggcggccaa gaaggccttt      900

gaagattgga aagccagcgt accaaacgca ccggaattag tgaacttcgc ggattctaat      960

ccgctgaccg gcatttggga gctgtgctcg gatcgtacgc agaaagcgaa actgaaaaaa     1020

cacttcgaga cggtgtgggc cccggcagaa agcgcgaagc gtcgggtaca tgcggattat     1080

atcgacgagg taacgtttgt tcttggcgat aactctgaca tccctgcgcc agcagggtat     1140

actaaggtac cagtggacct gaattctggg gcaggtggta aattcattta tctttgctat     1200

catgaagcgc agtttactcc cgtgaactct aagcaagcca tagttggctt gcaggtcttg     1260

tacgggaaac aagaaccagc acctgattat tcacgtatta acatagatct gaattctgga     1320

gcaaacgggg atgatgtcta cctttcttat aaaaaggggg acgccacttc gaaagaagtc     1380

atcaacaaaa tcactgcggt gtacgggaag gatcagtacg ttcccacacc gtatggctac     1440

aagcaaattc cgggggacct gaattcaggt gcgggtggcg actttgtcta tttttgtact     1500

tatcagggag gaactgaata a                                               1521


<210>  22
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Plu1415/Hmass protein.

<400>  22

Met Ser Asn Asp Lys Thr Gly Lys Ser Leu Glu Gln Glu Asn Ser Glu 
1               5                   10                  15      


Arg Asp Val Glu Ile Arg Asp Arg Asn Tyr Phe Arg Lys Leu Ser Leu 
            20                  25                  30          


Phe Asp Asp Thr Val Ile Ala Gly Ala Glu Met Ile Gly Thr Ser Tyr 
        35                  40                  45              


Asp Val Phe Gly Lys Tyr Cys Asn Val Gly Ser Cys Met Asn Ser Leu 
    50                  55                  60                  


Phe Asp Glu Arg Lys Ile Asn Ala Ser Glu Asp Asn Phe Lys Lys Val 
65                  70                  75                  80  


Thr Ile Leu Gly Lys Thr Leu Lys Val Pro Tyr Tyr Ile Asp Cys Tyr 
                85                  90                  95      


Ser Val Gly Asp Leu Lys Tyr Thr Asn Ala Ser Gly Glu Ser Ile Glu 
            100                 105                 110         


Ser Tyr Gln Ser Asn Ile Ser Ser Lys Ser Arg Ile Lys Gly Asn Tyr 
        115                 120                 125             


Leu Phe Phe Ser Ala Ser Leu Lys Val Asp Phe Asp Thr Asp Ser Leu 
    130                 135                 140                 


Thr Asp Phe Glu Asn Ala Phe Ser Arg Ile Gln Tyr Thr Tyr Asp Leu 
145                 150                 155                 160 


Tyr Ile Leu Lys Ser Ser Ala Glu Ala Leu Lys Glu Phe Leu Lys Glu 
                165                 170                 175     


Ser Val Lys Thr Ala Leu Asp Lys Ala Asp Thr Glu Glu Asp Met Asn 
            180                 185                 190         


Asp Leu Phe Asn Thr Trp Gly Ser His Phe Leu Ser Gly Val Val Met 
        195                 200                 205             


Gly Gly Cys Ala Gln Tyr Ser Ser Ser Thr Asn Lys Tyr Thr Ser Asn 
    210                 215                 220                 


Leu Thr Asn Ser Phe Asp Val Val Ala Ala Ala Ser Phe Ala Gly Phe 
225                 230                 235                 240 


Ile Gly Leu Ser Ala Arg Thr Gly Asn Ser Phe Met Glu Asp Ile Lys 
                245                 250                 255     


Lys Phe Arg Ser Ala Ser Asn Ile Lys Thr His Ala Ile Gly Gly Asp 
            260                 265                 270         


Leu Ser Arg Phe Asp Pro Phe Gly Gly Ala Thr Ser Ala Asp Gln Pro 
        275                 280                 285             


Ser Ala Glu Glu Ile Ala Ala Ala Lys Lys Ala Phe Glu Asp Trp Lys 
    290                 295                 300                 


Ala Ser Val Pro Asn Ala Pro Glu Leu Val Asn Phe Ala Asp Ser Asn 
305                 310                 315                 320 


Pro Leu Thr Gly Ile Trp Glu Leu Cys Ser Asp Arg Thr Gln Lys Ala 
                325                 330                 335     


Lys Leu Lys Lys His Phe Glu Thr Val Trp Ala Pro Ala Glu Ser Ala 
            340                 345                 350         


Lys Arg Arg Val His Ala Asp Tyr Ile Asp Glu Ile Phe Val Gly Tyr 
        355                 360                 365             


Gly Asp Thr Pro Asp Ala Ala Arg Ala Asp Val Tyr Ala Gln Met Ala 
    370                 375                 380                 


Ala Tyr Asp Pro Lys Ala Pro Glu Phe Ile Val Phe Lys Asp Leu Asn 
385                 390                 395                 400 


Cys Ser Ala Arg Gly Lys Tyr Glu Tyr Leu Gly Tyr Thr Val Thr Thr 
                405                 410                 415     


Asp Leu Lys Glu Ala Ile Arg Gly Met Arg Gly Ala Thr Asp Pro Asn 
            420                 425                 430         


Asp Arg Cys Ser Asp Thr Tyr Asn Val Gly Gly Cys Thr Tyr His Arg 
        435                 440                 445             


Leu Arg Arg Asp Leu Asn His Gly Ala Gly Gly His Tyr Val Tyr Leu 
    450                 455                 460                 


Tyr Trp Thr Lys Asp Ala Ala Ala Gly Lys Pro Leu Leu Ala Ala Asp 
465                 470                 475                 480 


Val Glu Ile Asn Tyr Ser Gly Phe Asp His Tyr Gly Gln Pro Gly Trp 
                485                 490                 495     


Ser Arg Val Arg Leu Ile Asn Asn Asp Gly Asp Leu Asn Thr Asn Arg 
            500                 505                 510         


Gly Thr Gly Ser Arg Thr Tyr Asp Ile Phe Val Trp Val Ser Lys Glu 
        515                 520                 525             


Leu 
    


<210>  23
<211>  1590
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric Plu1415/HmassCRW CDS.

<400>  23
atgtcaaacg ataaaacggg aaaaagtctg gaacaggaaa atagcgagcg cgacgttgaa       60

attcgcgatc gcaactactt tcgcaaattg agcttgtttg acgatactgt tatcgccggt      120

gcggagatga tcggtactag ctacgatgtg tttggcaagt actgcaatgt aggaagctgc      180

atgaacagcc tcttcgatga acgtaaaatc aacgcgagtg aagacaactt taaaaaagtt      240

accattttag gcaaaacgct caaggtaccg tattatatcg attgttattc tgtcggtgat      300

cttaaataca cgaacgcatc aggcgaatct atcgagagtt atcagtctaa catttcttct      360

aaaagtcgta tcaaaggtaa ctatctgttt ttttctgcct cactcaaggt cgatttcgat      420

acggatagcc tgacggattt cgagaatgcc ttctctcgta tccagtacac gtatgatttg      480

tatattttaa aatcatccgc ggaagccctc aaggaatttc tgaaagagtc agtcaaaacg      540

gcgttggaca aggcggatac cgaagaagac atgaacgacc tgtttaatac ttggggcagt      600

catttcctgt caggcgtagt gatgggtggt tgcgcgcaat acagttcgag tacgaataag      660

tatacctcaa atctgaccaa tagctttgac gttgttgcag cggcatcttt cgctggtttt      720

attggtctgt ccgcccgtac aggcaactca tttatggaag atattaaaaa atttcgctcc      780

gcatctaata ttaagaccca cgcgatcggt ggggatctca gccgcttcga tccgttcggc      840

ggcgccacct ccgccgatca accgtctgcc gaagagatcg cggcggccaa gaaggccttt      900

gaagattgga aagccagcgt accaaacgca ccggaattag tgaacttcgc ggattctaat      960

ccgctgaccg gcatttggga gctgtgctcg gatcgtacgc agaaagcgaa actgaaaaaa     1020

cacttcgaga cggtgtgggc cccggcagaa agcgcgaagc gtcgggtaca tgcggattat     1080

atcgacgaga ttttcgtagg ctatggggat acgccggacg cggcacgcgc agacgtatat     1140

gcacagatgg cggcatacga tccgaaggcc ccggagttta ttgtttttaa agatctgaat     1200

tgttcagctc gcggtaaata tgaatatctg ggatacactg tgacgaccga cctcaaagag     1260

gcgatccgcg gcatgcgcgg cgcaaccgac ccgaatgatc gctgttccga tacctataat     1320

gtgggtgggt gtacttacca ccggctgcgt cgggacctga accacggagc gggtgggcat     1380

tacgtgtatc tgtattggac caaagacgct gcggcgggca agccattgct tgccgcggat     1440

gtcgagatta attattcagg cttcgatcat tatgggcagc ccgggtggtc tcgtgttcgt     1500

ttgattaata atgatgggga cctcaatacg aatcgtggga cgggctcccg cacctatgac     1560

attttcgtat gggtttcaaa agaattgtaa                                      1590


