                         SEQUENCE LISTING

<110>  BioInvent International AB
 
<120>  NOVEL ANTAGONISTIC ANTIBODY MOLECULES

<130>  BI84 PCT

<150>  EP18203993.3
<151>  2018-11-01

<160>  223   

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  1

Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  2
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly Arg 
        


<210>  3
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  3

Cys Ala Arg Asp Arg Ser Ser Ser Trp Tyr Arg Asp Gly Met Asp Val 
1               5                   10                  15      


<210>  4
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  6
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
1               5                   10          


<210>  7
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Ser Ser Ser Trp Tyr Arg Asp Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  9
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  9

Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  10
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Thr Ile Tyr Ser Gly Asp Asn Ala Tyr Tyr Gly Ala Ser Val Arg 
1               5                   10                  15      


Gly Arg 
        


<210>  11
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Arg Val Tyr Ser Ser Ser Trp Arg Lys Arg Ala Phe Asp Ile 
1               5                   10                  15  


<210>  12
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Ser Gly Thr Ser Ser Asn Ile Glu Ser Asn Thr Val Asn 
1               5                   10                  


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Asp Asn Gln Arg Pro Ser 
1               5           


<210>  14
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
1               5                   10          


<210>  15
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Tyr Ser Gly Asp Asn Ala Tyr Tyr Gly Ala Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Tyr Ser Ser Ser Trp Arg Lys Arg Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Thr Ser Ser Asn Ile Glu Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  17
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  17

Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  18
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Leu Ile Trp Tyr Asp Gly Gly Asn Glu Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  19
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Arg Tyr Tyr Gly Asp Gly Gly Phe Asp Pro 
1               5                   10      


<210>  20
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  15  


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  22
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  22

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10          


<210>  23
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Tyr Asp Gly Gly Gly Lys Tyr Phe Ala Asp Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Asp Gly Gly Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  24
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  25
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  25

Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  26
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  26

Ala Leu Ile Trp Tyr Asp Gly Gly Asn Glu Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  27
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  27

Val Arg Glu Thr Gly Asn Tyr Gly Met Asp Val 
1               5                   10      


<210>  28
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  28

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  15  


<210>  29
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  29

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  30
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  30

Cys Ala Thr Trp Asp Asp Arg Val Asn Gly Pro Val 
1               5                   10          


<210>  31
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Gly Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Thr Gly Asn Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  32
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg 
                85                  90                  95      


Val Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  33
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  33

Phe Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  34
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  35
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Lys Asp Pro Leu Phe Asp Ser 
1               5               


<210>  36
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  36

Cys Thr Gly Arg Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  15  


<210>  37
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  37

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  38
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  38

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10          


<210>  39
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Leu Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  40
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Arg Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  41
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  41

Phe Asn Thr Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  42
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Val Leu Tyr Ser Asp Asp Asp Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly Arg 
        


<210>  43
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Arg Asp Cys Gly Gly Asp Cys His Ser Gly Asp Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  44
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  44

Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10                  


<210>  45
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  45

Asp Asn Asp Lys Arg Pro Ser 
1               5           


<210>  46
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  46

Cys Ala Ala Trp His Asp Ser Leu Asn Gly Trp Val 
1               5                   10          


<210>  47
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  47

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Leu Tyr Ser Asp Asp Asp Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Cys Gly Gly Asp Cys His Ser Gly Asp Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  48
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp His Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Leu Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  49
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  49

Phe Ser Ala Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  50
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  50

Ala Val Val Ser Tyr Asp Gly Arg Glu Lys His Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  51
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  51

Ala Arg Ser Asp Gly Gly Tyr Asp Ser Asp Ser Gly Tyr Tyr 
1               5                   10                  


<210>  52
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  52

Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn Phe Val Tyr 
1               5                   10                  


<210>  53
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  53

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  54
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  54

Cys Ser Ser Tyr Ala Tyr Ser Asp Asn Ile Leu 
1               5                   10      


<210>  55
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Tyr Asp Gly Arg Glu Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Gly Gly Tyr Asp Ser Asp Ser Gly Tyr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  56
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Phe Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Tyr Ser Asp 
                85                  90                  95      


Asn Ile Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  57
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  57

Phe Ser Asn Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  58
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  58

Ser Gly Ile Ser Ser Ser Gly Ser Ser Ala Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  59
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Arg His Tyr Tyr Tyr His Ile Ala Gly Tyr Tyr Tyr Asp Thr Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  60
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  60

Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Thr Val Asn 
1               5                   10                  


<210>  61
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Asn Thr Asn Arg Pro Ser 
1               5           


<210>  62
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  62

Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10          


<210>  63
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  63

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Ser Ser Gly Ser Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Tyr Tyr His Ile Ala Gly Tyr Tyr Tyr Asp Thr Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  64
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  65
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  65

Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  66
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  66

Ala Thr Ile Ser Tyr His Gly Ser Asp Lys Asp Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  67
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  67

Ala Arg Asp Ala Asn Tyr His Ser Ser Gly Tyr Tyr Tyr Asp Val Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  68
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  68

Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10                  


<210>  69
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  69

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  70
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  70

Cys Ala Ala Trp Asp Asp Ser Leu Ser Thr Trp Val 
1               5                   10          


<210>  71
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  71

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr His Gly Ser Asp Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Asn Tyr His Ser Ser Gly Tyr Tyr Tyr Asp Val Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  72
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  72

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  73
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  73

Phe Ser Asp Tyr Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  74
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  74

Ser Gly Ile Ser Gly Ser Gly Gly Tyr Ile His Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  75
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Arg Glu Gly Leu Leu Pro Asp Ala Phe Asp 
1               5                   10      


<210>  76
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  76

Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10                  


<210>  77
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  77

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  78
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  78

Cys Ala Ala Trp Asp Asp Ser Val Ser Gly Trp Val 
1               5                   10          


<210>  79
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  79

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Tyr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Leu Pro Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  80
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  80

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Val 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  81
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  81

Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  82
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  82

Ala Val Met Ser Tyr Asp Glu Tyr Asn Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  83
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  83

Ala Lys Gly Phe Tyr Gly Asp Tyr Pro Leu Trp Asp Tyr 
1               5                   10              


<210>  84
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  84

Cys Ser Gly Gly Asn Ser Asn Ile Gly Thr Asn Thr Val Asp 
1               5                   10                  


<210>  85
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  85

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  86
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  86

Cys Ala Ala Trp Asp Asp Ser Val Asn Gly Pro Val 
1               5                   10          


<210>  87
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  87

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Met Ser Tyr Asp Glu Tyr Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Phe Tyr Gly Asp Tyr Pro Leu Trp Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  88
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  88

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Asn Ser Asn Ile Gly Thr Asn 
            20                  25                  30          


Thr Val Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Val 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  89
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  89

Phe Ser Ser Tyr Glu Met Asn Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  90
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  90

Ser Thr Ile Thr Gly Gly Gly Ser Ile Tyr Asp Ala Asn Ser Val Gln 
1               5                   10                  15      


Gly Arg 
        


<210>  91
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  91

Ala Arg Asp Ser Thr Tyr His Ser Ser Gly Tyr Tyr Tyr Asp Val Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  92
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  92

Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10                  


<210>  93
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  93

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  94
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  94

Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly His Trp Val 
1               5                   10              


<210>  95
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  95

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Thr Gly Gly Gly Ser Ile Tyr Asp Ala Asn Ser Val Gln 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ser Thr Tyr His Ser Ser Gly Tyr Tyr Tyr Asp Val Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  96
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  96

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  97
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  97

Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  98
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  98

Ser Ala Val Phe Gly Ser Gly His Gly Asn Thr Phe Tyr Ala Asp Ala 
1               5                   10                  15      


Val Lys Gly Arg 
            20  


<210>  99
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  99

Ala Arg Glu Gln Leu Trp Phe Gly Gln Asp Ala Phe Asp Ile 
1               5                   10                  


<210>  100
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  100

Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10                  


<210>  101
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  101

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  102
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  102

Cys Gln Ser Tyr Asp Ser Ser Leu Ser Ala Ser Val 
1               5                   10          


<210>  103
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  103

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Pro Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Val Phe Gly Ser Gly His Gly Asn Thr Phe Tyr Ala Asp Ala 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Gln Leu Trp Phe Gly Gln Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  104
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  104

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  105
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  105

Phe Ser Asp Ala Trp Met Thr Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  106
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  106

Ser Asp Leu Ser Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  107
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  107

Gly Arg Leu Ala Ala Gly Gly Pro Val Asp Tyr 
1               5                   10      


<210>  108
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  108

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  15  


<210>  109
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  109

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  110
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  110

Cys Ser Val Trp Asp Asp Ser Leu Asn Ser Trp Val 
1               5                   10          


<210>  111
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  111

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Leu Ser Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Leu Ala Ala Gly Gly Pro Val Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  112
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  112

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Val Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  113
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  113

Phe Ser Asp Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  114
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  114

Ala Asn Ile Asn Thr Asp Gly Ser Glu Lys Tyr Tyr Leu Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  115
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  115

Ala Arg Glu Glu Tyr Gly Ala Phe Asp Ile 
1               5                   10  


<210>  116
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  116

Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10                  


<210>  117
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  117

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  118
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  118

Cys Gln Ser Phe Asp Arg Gly Leu Ser Gly Ser Ile Val 
1               5                   10              


<210>  119
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  119

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Thr Asp Gly Ser Glu Lys Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Tyr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  120
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  120

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Arg Gly Leu 
                85                  90                  95      


Ser Gly Ser Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  121
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  121

Phe Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  122
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  122

Ser Ala Ile Ser Gly Gly Ala Thr Thr Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  123
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  123

Ala Lys Gly Gly Thr Gly Asp Pro Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  124
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  124

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  15  


<210>  125
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  125

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  126
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  126

Cys Ala Ala Arg Asp Asp Gly Leu Ser Gly Pro Val 
1               5                   10          


<210>  127
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  127

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Ala Thr Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Thr Gly Asp Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  128
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  128

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Arg Asp Asp Gly 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  129
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  129

Phe Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  130
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  130

Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  131
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  131

Ala Arg Asp Arg Gly Trp Phe Asp Pro 
1               5                   


<210>  132
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  132

Cys Ser Gly Ser Arg Ser Asn Ile Asp Asn Ser Tyr Val Ser 
1               5                   10                  


<210>  133
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  133

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  134
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  134

Cys Ala Thr Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10          


<210>  135
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  135

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  136
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  136

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Asp Asn Ser 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  137
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  137

Phe Ser Asn Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  138
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  138

Ser Ser Ile Ser Ser Ala Ser Gly Tyr Ile Tyr Tyr Gly Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  139
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  139

Ala Arg Gly Thr Leu Tyr Gly Asp Phe Asp Glu Phe 
1               5                   10          


<210>  140
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  140

Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10                  


<210>  141
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  141

Gly Asn Thr Asn Arg Pro Ser 
1               5           


<210>  142
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  142

Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val Val 
1               5                   10              


<210>  143
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  143

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ala Ser Gly Tyr Ile Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Leu Tyr Gly Asp Phe Asp Glu Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  144
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  144

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Gly Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  145
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  145

Phe Ser Arg His Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  146
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  146

Ser Ser Ile Ser Thr Gly Ser Ser Tyr Ile Asp Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  147
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  147

Ala Arg Glu Lys Gly His Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210>  148
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  148

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  15  


<210>  149
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  149

Gly Asn Ser Tyr Arg Pro Ser 
1               5           


<210>  150
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  150

Cys Gln Ser Tyr Asp Thr Ser Leu Ser Ala Tyr Val Val 
1               5                   10              


<210>  151
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  151

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Thr Gly Ser Ser Tyr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Gly His Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  152
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  152

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Thr Ser 
                85                  90                  95      


Leu Ser Ala Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly 
    


<210>  153
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  153

Phe Ser Asn Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  154
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  154

Ser Ala Ile Ser Val Ser Gly Ile Asn Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  155
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  155

Ala Arg Asp Thr Gly Ser Leu Gly Val Asp Tyr 
1               5                   10      


<210>  156
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  156

Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10                  


<210>  157
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  157

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  158
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  158

Cys Gln Ser Tyr Asp Ser Ser Leu Ser Ile Ser Val 
1               5                   10          


<210>  159
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  159

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Val Ser Gly Ile Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Gly Ser Leu Gly Val Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  160
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  160

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Ile Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  161
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  161

Phe Ser Ser Asn Glu Met Ser Trp Ile Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  162
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  162

Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly Arg 
        


<210>  163
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  163

Ala Arg Arg Glu Gly Trp Leu Val Pro Phe Asp Tyr 
1               5                   10          


<210>  164
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  164

Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10                  


<210>  165
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  165

Gly Asn Ile Ile Arg Pro Ser 
1               5           


<210>  166
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  166

Cys Gln Ser Phe Asp Thr Thr Leu Ser Gly Ser Ile Val 
1               5                   10              


<210>  167
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  167

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Glu Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Glu Gly Trp Leu Val Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  168
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  168

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ile Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Thr Thr Leu 
                85                  90                  95      


Ser Gly Ser Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  169
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  169

Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  170
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  170

Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ala Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  171
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  171

Thr Thr Asp Ser Gly Ser Gly Ser Tyr Leu 
1               5                   10  


<210>  172
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  172

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  15  


<210>  173
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  173

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  174
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  174

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10          


<210>  175
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  175

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Asp Ser Gly Ser Gly Ser Tyr Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  176
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  176

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  177
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  177

Ser Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  178
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  178

Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  179
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  179

Ala Arg Glu Tyr Ser Gly Tyr Glu Phe Asp Phe 
1               5                   10      


<210>  180
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  180

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Arg Ser Asp Val His 
1               5                   10                  15  


<210>  181
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  181

Gly Asn Arg Asn Arg Pro Ser 
1               5           


<210>  182
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  182

Cys Gln Ser Phe Asp Arg Gly Leu Ser Gly Ser Ile Val 
1               5                   10              


<210>  183
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  183

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Ser Gly Tyr Glu Phe Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  184
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  184

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Arg 
            20                  25                  30          


Ser Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Arg Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Arg Gly 
                85                  90                  95      


Leu Ser Gly Ser Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly 
    


<210>  185
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  185

Ser Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  186
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  186

Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  187
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  187

Ala Arg Glu Tyr Ser Gly Tyr Glu Phe Asp Phe 
1               5                   10      


<210>  188
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  188

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Arg Ser Asp Val His 
1               5                   10                  15  


<210>  189
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  189

Gly Asn Arg Asn Arg Pro Ser 
1               5           


<210>  190
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  190

Cys Gln Ser Phe Asp Arg Gly Leu Ser Gly Ser Ile Val 
1               5                   10              


<210>  191
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  191

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Ser Gly Tyr Glu Phe Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  192
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  192

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Arg 
            20                  25                  30          


Ser Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Arg Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Arg Gly 
                85                  90                  95      


Leu Ser Gly Ser Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly 
    


<210>  193
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  193

Phe Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  194
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  194

Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  195
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  195

Ala Arg Asp Arg Gly Arg Thr Gly Thr Asp Tyr 
1               5                   10      


<210>  196
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  196

Cys Ser Gly Thr Thr Ser Asn Ile Gly Ser Tyr Ala Val Asn 
1               5                   10                  


<210>  197
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  197

Gly Asn Ile Asn Arg Pro Ser 
1               5           


<210>  198
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  198

Cys Gln Ser Tyr Asp Ser Ser Leu Ser Ala Ser Leu 
1               5                   10          


<210>  199
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  199

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Arg Thr Gly Thr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  200
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  200

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Thr Thr Ser Asn Ile Gly Ser Tyr 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Ser Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  201
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  201

Phe Ser Arg Tyr Trp Met His Trp Val Arg Gln Val Pro Gly 
1               5                   10                  


<210>  202
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  202

Ser Gly Ile Ser Asp Ser Gly Val Val Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  203
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  203

Ala Arg Ala Gln Ser Val Ala Phe Asp Ile 
1               5                   10  


<210>  204
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  204

Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly His Asp Val His 
1               5                   10                  15  


<210>  205
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  205

Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  206
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  206

Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
1               5                   10          


<210>  207
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  207

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Asp Ser Gly Val Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Ser Val Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  208
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  208

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


His Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  209
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  209

Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  210
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  210

Ser Thr Ile Ile Gly Ser Gly Ala Asn Thr Trp Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  211
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  211

Ala Arg His Glu Gly Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210>  212
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  212

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Val Val His 
1               5                   10                  15  


<210>  213
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  213

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  214
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  214

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 
1               5                   10          


<210>  215
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  215

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ile Gly Ser Gly Ala Asn Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  216
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  216

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  217
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  217

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  218
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  218

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  219
<211>  330
<212>  PRT
<213>  Mus musculus

<400>  219

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            100                 105                 110         


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                 150                 155                 160 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                 170                 175     


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                 230                 235                 240 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                 250                 255     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                 265                 270         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                 280                 285             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                 295                 300                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                 310                 315                 320 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                 330 


<210>  220
<211>  330
<212>  PRT
<213>  Mus musculus

<400>  220

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            100                 105                 110         


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                 150                 155                 160 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                 170                 175     


Glu Asp Tyr Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                 230                 235                 240 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                 250                 255     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                 265                 270         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                 280                 285             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                 295                 300                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                 310                 315                 320 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                 330 


<210>  221
<211>  105
<212>  PRT
<213>  Mus musculus

<400>  221

Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe 
            20                  25                  30          


Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val 
        35                  40                  45              


Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg 
65                  70                  75                  80  


His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu 
                85                  90                  95      


Lys Ser Leu Ser Arg Ala Asp Cys Ser 
            100                 105 


<210>  222
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  222
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagtac atattacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc cgaggacact gccgtgtatt actgtgcgag agatcgaagc      300

agcagctggt accgcgatgg tatggacgtc tggggccaag gtacactggt caccgtgagc      360

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaatga                               1356


<210>  223
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  223
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtatcagcag      120

ctcccaggaa cggcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cggtccgagg atgaggctga ttattactgt gcagcatggg atgacagcct gagtggttgg      300

gtgttcggcg gaggaaccaa gctgacggtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atga            654


