                         SEQUENCE LISTING

<110>  ԴҽҩƼϺ޹˾
 
<120>  CD19CD3ͬԴ˫Կ弰Ʊ;

<130>  201811

<150>  CN 201811294887.4
<151>  2018-11-01

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  CD191_HCDR1

<400>  1

Ser Tyr Trp Met Asn 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  CD191_HCDR2

<400>  2

Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  15
<212>  PRT
<213>  CD191_HCDR3

<400>  3

Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  CD191_LCDR1

<400>  4

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Leu Asn 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  CD191_LCDR2

<400>  5

Asp Ala Ser Asn Leu Val Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  CD191_LCDR3

<400>  6

Gln Gln Ser Thr Glu Asp Pro Trp Thr 
1               5                   


<210>  7
<211>  124
<212>  PRT
<213>  CD191_VH

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  8
<211>  111
<212>  PRT
<213>  CD191_VL

<400>  8

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  9
<211>  5
<212>  PRT
<213>  CD192_HCDR1

<400>  9

Ser Asn Trp Met His 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  CD192_HCDR2

<400>  10

Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  11
<212>  PRT
<213>  CD192_HCDR3

<400>  11

Gly Ser Asn Pro Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  12
<211>  10
<212>  PRT
<213>  CD192_LCDR1

<400>  12

Ser Ala Ser Ser Gly Val Asn Tyr Met His 
1               5                   10  


<210>  13
<211>  7
<212>  PRT
<213>  CD19237_LCDR2

<400>  13

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  CD192_LCDR3

<400>  14

His Gln Arg Gly Ser Tyr Thr 
1               5           


<210>  15
<211>  120
<212>  PRT
<213>  CD192_VH

<400>  15

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Gln Gly Lys Ala Lys Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Asn Pro Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  104
<212>  PRT
<213>  CD192_VL

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Ser Ala Ser Ser Gly Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Arg Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Gly Ser Tyr Thr Phe Gly 
                85                  90                  95      


Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 


<210>  17
<211>  7
<212>  PRT
<213>  CD193567_HCDR1

<400>  17

Thr Ser Gly Met Gly Val Gly 
1               5           


<210>  18
<211>  16
<212>  PRT
<213>  CD193567_HCDR2

<400>  18

His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  19
<211>  10
<212>  PRT
<213>  CD193567_HCDR3

<400>  19

Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  CD1937_LCDR1

<400>  20

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  21
<211>  9
<212>  PRT
<213>  CD193567_LCDR3

<400>  21

Phe Gln Gly Ser Val Tyr Pro Phe Thr 
1               5                   


<210>  22
<211>  120
<212>  PRT
<213>  CD193_VH

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  106
<212>  PRT
<213>  CD193_VL

<400>  23

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Val Ala Val Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  24
<211>  5
<212>  PRT
<213>  CD194_HCDR1

<400>  24

Ser Ser Trp Met Asn 
1               5   


<210>  25
<211>  17
<212>  PRT
<213>  CD194_HCDR2

<400>  25

Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Val Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  12
<212>  PRT
<213>  CD194_HCDR3

<400>  26

Ser Gly Phe Ile Thr Thr Val Arg Asp Phe Asp Tyr 
1               5                   10          


<210>  27
<211>  15
<212>  PRT
<213>  CD194_LCDR1

<400>  27

Arg Ala Ser Glu Ser Val Asp Thr Phe Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  28
<211>  7
<212>  PRT
<213>  CD194_LCDR2

<400>  28

Glu Ala Ser Asn Gln Gly Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  CD194_LCDR3

<400>  29

Gln Gln Ser Lys Glu Val Pro Phe Thr 
1               5                   


<210>  30
<211>  121
<212>  PRT
<213>  CD194_VH

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Phe Ile Thr Thr Val Arg Asp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  31
<211>  111
<212>  PRT
<213>  CD194_VL

<400>  31

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Thr Phe 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Asp Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile His Glu Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  32
<211>  10
<212>  PRT
<213>  CD1956_LCDR1

<400>  32

Arg Ala Ser Gln Ser Val Ser Tyr Met His 
1               5                   10  


<210>  33
<211>  7
<212>  PRT
<213>  CD1956_LCDR2

<400>  33

Asp Ala Ser Asn Arg Ala Ser 
1               5           


<210>  34
<211>  120
<212>  PRT
<213>  CD195_VH

<400>  34

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  35
<211>  106
<212>  PRT
<213>  CD195_VL

<400>  35

Glu Asn Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Lys Ala Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ala Ser Asn Arg Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp His Thr Leu Thr Ile Ser Ser Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  36
<211>  120
<212>  PRT
<213>  CD196_VH

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  37
<211>  106
<212>  PRT
<213>  CD196_VL

<400>  37

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ala Ser Asn Arg Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  38
<211>  120
<212>  PRT
<213>  CD197_VH

<400>  38

Gln Val Gln Leu Gln Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  39
<211>  106
<212>  PRT
<213>  CD197_VL

<400>  39

Glu Asn Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Lys Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp His Thr Leu Thr Ile Ser Ser Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Val Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  40
<211>  5
<212>  PRT
<213>  CD3-3_HCDR1

<400>  40

Thr Tyr Ala Met Asn 
1               5   


<210>  41
<211>  19
<212>  PRT
<213>  CD3-3_HCDR2

<400>  41

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  42
<211>  14
<212>  PRT
<213>  CD3-3_HCDR3

<400>  42

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  43
<211>  14
<212>  PRT
<213>  CD3-3_LCDR1

<400>  43

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  44
<211>  7
<212>  PRT
<213>  CD3-3_LCDR2

<400>  44

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  45
<211>  9
<212>  PRT
<213>  CD3-3_LCDR3

<400>  45

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  46
<211>  125
<212>  PRT
<213>  CD3-3_VH

<400>  46

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  47
<211>  109
<212>  PRT
<213>  CD3-3_VL

<400>  47

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  48
<211>  28
<212>  PRT
<213>  CTP: hCG £118-145

<400>  48

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  49
<211>  27
<212>  PRT
<213>  G2(GGGGS)3CTP1

<400>  49

Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
            20                  25          


<210>  50
<211>  25
<212>  PRT
<213>  (GGGGS)3CTP1

<400>  50

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
1               5                   10                  15      


Ser Ser Ser Lys Ala Pro Pro Pro Ser 
            20                  25  


<210>  51
<211>  22
<212>  PRT
<213>  GS(GGGGS)2CTP1

<400>  51

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Ser Ser 
1               5                   10                  15      


Lys Ala Pro Pro Pro Ser 
            20          


<210>  52
<211>  33
<212>  PRT
<213>  (GGGGS)1CTP4

<400>  52

Gly Gly Gly Gly Ser Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu 
1               5                   10                  15      


Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro 
            20                  25                  30          


Gln 
    


<210>  53
<211>  227
<212>  PRT
<213>  IgG1 Fc(L234A,L235A)ͻ㶨

<400>  53

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  54
<211>  226
<212>  PRT
<213>  IgG1(L234A,L235A, T250Q,N297A,P331S,M428L,K447-)ͻ㶨

<400>  54

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  55
<211>  743
<212>  PRT
<213>  AB23P7

<400>  55

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Phe Gln 
    210                 215                 220                 


Gly Ser Val Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Glu Val Gln Leu 
            260                 265                 270         


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
305                 310                 315                 320 


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
            340                 345                 350         


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
        355                 360                 365             


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro 
                405                 410                 415     


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser 
            420                 425                 430         


Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln 
        435                 440                 445             


Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg 
    450                 455                 460                 


Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
465                 470                 475                 480 


Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                485                 490                 495     


Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr 
            500                 505                 510         


Lys Leu Thr Val Leu Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        515                 520                 525             


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    530                 535                 540                 


Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
545                 550                 555                 560 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                565                 570                 575     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            580                 585                 590         


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        595                 600                 605             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    610                 615                 620                 


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
625                 630                 635                 640 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                645                 650                 655     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            660                 665                 670         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        675                 680                 685             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    690                 695                 700                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
705                 710                 715                 720 


Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                725                 730                 735     


Ser Leu Ser Leu Ser Pro Gly 
            740             


<210>  56
<211>  2307
<212>  DNA
<213>  AB23P7

<400>  56
actagtcgcc accatgagga gcctcggggc cctgctcttg ctgctgagcg cctgcctggc       60

ggtgagcgct caggtgcagc tgcaggagag cggaccagga ctggtgaagc catcccagac      120

cctgagcctg acctgtacag tgtctggcgg cagcatctct acatccggaa tgggagtggg      180

atggatcagg cagcacccag gcaagggcct ggaatggatc ggccatatct ggtgggacga      240

tgacaagaga tacaatcctg ccctgaagtc ccgcgtgaca atctctgtgg acacctccaa      300

gaaccagttt agcctgaagc tgtcttccgt gacagccgct gataccgccg tgtattactg      360

cgctagaatg gagctgtgga gctattactt cgactactgg ggccagggca cactggtgac      420

cgtgagctcc ggtggtggtg gttccggcgg cggcggttct ggcggcggcg gcagcgagat      480

cgtgctgaca cagtcccctg ccaccctgag cctgtctcca ggagagaggg ccaccctgtc      540

ctgttccgcc tccagctctg tgagctacat gcattggtat cagcagaagc caggccaggc      600

tcccaggctg ctgatctacg atacttctaa actggcctct ggcatccctg ctcggttttc      660

tggctccggc agcggcacag acttcaccct gacaatctcc agcctggagc cagaggatgt      720

ggccgtgtat tactgcttcc agggcagcgt gtatcccttc acatttggcc agggcactaa      780

actggagatc aagggtggcg gcggtggagg atccggcggt ggaggtagcg gcggaggcgg      840

tagctccagc tctagtaaag ctccccctcc ttccgaggtg cagctgctgg agtccggagg      900

aggactggtg cagccaggag gctccctgaa gctgagctgt gctgcctctg gctttacctt      960

caacacatat gccatgaatt gggtgcggca ggctccaggc aagggactgg agtgggtggc     1020

taggatcagg tctaagtaca acaattatgc cacctactat gctgattccg tgaaggacag     1080

gttcaccatc tcccgcgacg atagcaagaa cacagcctac ctgcagatga acaatctgaa     1140

gaccgaggat accgccgtgt actactgcgt gagacatggc aactttggca atagctacgt     1200

gtcctggttc gcttactggg gacagggcac cctggtcaca gtgagctctg gaggaggagg     1260

atctggagga ggaggctccg gaggaggagg aagcgagctg gtggtgaccc aggagccatc     1320

tctgacagtg tcccccggcg gcacagtgac cctgacatgt agatccagca ccggcgccgt     1380

gaccacatcc aactacgcta attgggtgca gcagaagcca ggacaggctc caaggggact     1440

gatcggagga accaacaaga gggctcctgg aacaccagct cggtttagcg gatctctgct     1500

gggaggcaag gctgccctga ccctgtccgg agtgcagcca gaggatgagg ccgagtatta     1560

ttgcgctctg tggtatagca atctgtgggt gttcggagga ggaaccaagc tgacagtgct     1620

ggacaagacc catacatgcc caccatgccc tgcccctgaa gccgccggag gaccttccgt     1680

gttcctgttc cctcccaagc caaaagatca gctgatgatc tctagaaccc ccgaagtcac     1740

ctgcgtggtc gtcgacgtgt cccatgagga ccctgaagtc aagttcaact ggtacgtgga     1800

cggtgtcgaa gtccacaacg ccaagaccaa gcctagggag gagcagtatg ccagcacata     1860

ccgggtggtg tctgtgctga ccgtgctgca tcaggattgg ctgaatggca aggaatataa     1920

atgtaaggtg agcaataagg ctctgccggc tagcattgaa aaaaccattt ccaaggctaa     1980

gggccagccc agggagcctc aggtctacac cctgcctcca tctagagatg aactgaccaa     2040

aaaccaggtg agcctgactt gcctggtcaa aggcttctac cccagcgaca ttgccgtgga     2100

gtgggagtct aatggccagc ctgaaaataa ctacaaaact acccctcctg tgctggactc     2160

tgatggctcc ttctttctgt actctaaact gaccgtggac aagtctcgct ggcagcaggg     2220

taacgtgttt tcttgctccg tgctgcacga ggctctgcat aaccattaca cccagaagag     2280

cctgtctctg tccccaggat agaattc                                         2307


<210>  57
<211>  743
<212>  PRT
<213>  AB23P8

<400>  57

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Val Thr Pro Gly Glu Lys Ala Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp His Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Phe Gln 
    210                 215                 220                 


Gly Ser Val Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Glu Val Gln Leu 
            260                 265                 270         


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
305                 310                 315                 320 


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
            340                 345                 350         


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
        355                 360                 365             


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro 
                405                 410                 415     


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser 
            420                 425                 430         


Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln 
        435                 440                 445             


Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg 
    450                 455                 460                 


Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
465                 470                 475                 480 


Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                485                 490                 495     


Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr 
            500                 505                 510         


Lys Leu Thr Val Leu Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        515                 520                 525             


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    530                 535                 540                 


Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
545                 550                 555                 560 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                565                 570                 575     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            580                 585                 590         


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        595                 600                 605             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    610                 615                 620                 


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
625                 630                 635                 640 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                645                 650                 655     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            660                 665                 670         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        675                 680                 685             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    690                 695                 700                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
705                 710                 715                 720 


Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                725                 730                 735     


Ser Leu Ser Leu Ser Pro Gly 
            740             


<210>  58
<211>  2307
<212>  DNA
<213>  AB23P8

<400>  58
actagtcgcc accatgagga gcctcggggc cctgctcttg ctgctgagcg cctgcctggc       60

ggtgagcgct caggtgaccc tgagggagtc cggacctgcc ctggtgaagc caacacagac      120

cctgacactg acctgtacct tctccggctt ctctctgtcc accagcggaa tgggagtggg      180

atggatcagg cagccacctg gcaaggccct ggagtggctg gctcacatct ggtgggacga      240

tgacaagaga tacaacccag ctctgaagtc tcgcctgacc atcagcaagg atacatctaa      300

gaaccaggtg tttctgacca tgacaaatat ggaccccgtg gacaccgcca catactattg      360

cgctcgcatg gagctgtggt cctactattt cgactactgg ggccagggta caaccgtcac      420

cgtgagctct ggtggtggtg gttccggcgg cggcggttct ggcggcggcg gcagcgagaa      480

cgtgctgaca cagtctccag ccaccctgtc cgtgacacct ggagagaagg ccaccatcac      540

atgtagagct tctcagtccg tgagctacat gcactggtat cagcagaagc caggacaggc      600

tccaaggctg ctgatctacg acgcctccaa tagggctagc ggcgtgcctt ctcggttttc      660

tggttctggc agcggcaccg atcataccct gacaatctcc agcctggagg ctgaagatgc      720

tgctacatac tattgtttcc agggcagcgt gtatcccttc accttcggcc agggtaccaa      780

gctggagatc aagggtggcg gcggtggagg atccggcggt ggaggtagcg gcggaggcgg      840

tagctccagc tctagtaaag ctccccctcc ttccgaggtg cagctgctgg agtccggagg      900

aggactggtg cagccaggag gctccctgaa gctgagctgt gctgcctctg gctttacctt      960

caacacatat gccatgaatt gggtgcggca ggctccaggc aagggactgg agtgggtggc     1020

taggatcagg tctaagtaca acaattatgc cacctactat gctgattccg tgaaggacag     1080

gttcaccatc tcccgcgacg atagcaagaa cacagcctac ctgcagatga acaatctgaa     1140

gaccgaggat accgccgtgt actactgcgt gagacatggc aactttggca atagctacgt     1200

gtcctggttc gcttactggg gacagggcac cctggtcaca gtgagctctg gaggaggagg     1260

atctggagga ggaggctccg gaggaggagg aagcgagctg gtggtgaccc aggagccatc     1320

tctgacagtg tcccccggcg gcacagtgac cctgacatgt agatccagca ccggcgccgt     1380

gaccacatcc aactacgcta attgggtgca gcagaagcca ggacaggctc caaggggact     1440

gatcggagga accaacaaga gggctcctgg aacaccagct cggtttagcg gatctctgct     1500

gggaggcaag gctgccctga ccctgtccgg agtgcagcca gaggatgagg ccgagtatta     1560

ttgcgctctg tggtatagca atctgtgggt gttcggagga ggaaccaagc tgacagtgct     1620

ggacaagacc catacatgcc caccatgccc tgcccctgaa gccgccggag gaccttccgt     1680

gttcctgttc cctcccaagc caaaagatca gctgatgatc tctagaaccc ccgaagtcac     1740

ctgcgtggtc gtcgacgtgt cccatgagga ccctgaagtc aagttcaact ggtacgtgga     1800

cggtgtcgaa gtccacaacg ccaagaccaa gcctagggag gagcagtatg ccagcacata     1860

ccgggtggtg tctgtgctga ccgtgctgca tcaggattgg ctgaatggca aggaatataa     1920

atgtaaggtg agcaataagg ctctgccggc tagcattgaa aaaaccattt ccaaggctaa     1980

gggccagccc agggagcctc aggtctacac cctgcctcca tctagagatg aactgaccaa     2040

aaaccaggtg agcctgactt gcctggtcaa aggcttctac cccagcgaca ttgccgtgga     2100

gtgggagtct aatggccagc ctgaaaataa ctacaaaact acccctcctg tgctggactc     2160

tgatggctcc ttctttctgt actctaaact gaccgtggac aagtctcgct ggcagcaggg     2220

taacgtgttt tcttgctccg tgctgcacga ggctctgcat aaccattaca cccagaagag     2280

cctgtctctg tccccaggat agaattc                                         2307


<210>  59
<211>  743
<212>  PRT
<213>  AB23P9

<400>  59

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Phe Gln 
    210                 215                 220                 


Gly Ser Val Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Glu Val Gln Leu 
            260                 265                 270         


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
305                 310                 315                 320 


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
            340                 345                 350         


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
        355                 360                 365             


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro 
                405                 410                 415     


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser 
            420                 425                 430         


Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln 
        435                 440                 445             


Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg 
    450                 455                 460                 


Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
465                 470                 475                 480 


Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                485                 490                 495     


Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr 
            500                 505                 510         


Lys Leu Thr Val Leu Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        515                 520                 525             


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    530                 535                 540                 


Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
545                 550                 555                 560 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                565                 570                 575     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            580                 585                 590         


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        595                 600                 605             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    610                 615                 620                 


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
625                 630                 635                 640 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                645                 650                 655     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            660                 665                 670         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        675                 680                 685             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    690                 695                 700                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
705                 710                 715                 720 


Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                725                 730                 735     


Ser Leu Ser Leu Ser Pro Gly 
            740             


<210>  60
<211>  2307
<212>  DNA
<213>  AB23P9

<400>  60
actagtcgcc accatgagga gcctcggggc cctgctcttg ctgctgagcg cctgcctggc       60

ggtgagcgct caggtgcagc tgcaggagag cggaccagga ctggtgaagc caacccagac      120

cctgagcctg acctgtacag tgtctggcgg cagcatctct acatccggaa tgggagtggg      180

atggatcagg cagcacccag gcaagggcct ggaatggatc ggccatatct ggtgggacga      240

tgacaagaga tacaatcctg ccctgaagtc ccgcgtgaca atctctgtgg acacctccaa      300

gaaccaggtc ttcctgaagc tgtcttccgt gacagccgct gataccgccg tgtattactg      360

cgctagaatg gagctgtgga gctattactt cgactactgg ggccagggca caaccgtgac      420

cgtgagctcc ggtggtggtg gttccggcgg cggcggttct ggcggcggcg gcagcgagat      480

cgtgctgaca cagtcccctg ccaccctgag cctgtctcca ggagagaggg ccaccatcac      540

ctgtagggcc tcccagtctg tgagctacat gcattggtat cagcagaagc caggccaggc      600

tcccaggctg ctgatctacg atgcttctaa tcgggcctct ggcgtgcctt cccggttttc      660

tggctccggc agcggcacag acttcaccct gacaatctcc agcctggagc cagaggatgc      720

ggccacctat tactgcttcc agggcagcgt gtatcccttc acatttggcc agggcactaa      780

actggagatc aagggtggcg gcggtggagg atccggcggt ggaggtagcg gcggaggcgg      840

tagctccagc tctagtaaag ctccccctcc ttccgaggtg cagctgctgg agtccggagg      900

aggactggtg cagccaggag gctccctgaa gctgagctgt gctgcctctg gctttacctt      960

caacacatat gccatgaatt gggtgcggca ggctccaggc aagggactgg agtgggtggc     1020

taggatcagg tctaagtaca acaattatgc cacctactat gctgattccg tgaaggacag     1080

gttcaccatc tcccgcgacg atagcaagaa cacagcctac ctgcagatga acaatctgaa     1140

gaccgaggat accgccgtgt actactgcgt gagacatggc aactttggca atagctacgt     1200

gtcctggttc gcttactggg gacagggcac cctggtcaca gtgagctctg gaggaggagg     1260

atctggagga ggaggctccg gaggaggagg aagcgagctg gtggtgaccc aggagccatc     1320

tctgacagtg tcccccggcg gcacagtgac cctgacatgt agatccagca ccggcgccgt     1380

gaccacatcc aactacgcta attgggtgca gcagaagcca ggacaggctc caaggggact     1440

gatcggagga accaacaaga gggctcctgg aacaccagct cggtttagcg gatctctgct     1500

gggaggcaag gctgccctga ccctgtccgg agtgcagcca gaggatgagg ccgagtatta     1560

ttgcgctctg tggtatagca atctgtgggt gttcggagga ggaaccaagc tgacagtgct     1620

ggacaagacc catacatgcc caccatgccc tgcccctgaa gccgccggag gaccttccgt     1680

gttcctgttc cctcccaagc caaaagatca gctgatgatc tctagaaccc ccgaagtcac     1740

ctgcgtggtc gtcgacgtgt cccatgagga ccctgaagtc aagttcaact ggtacgtgga     1800

cggtgtcgaa gtccacaacg ccaagaccaa gcctagggag gagcagtatg ccagcacata     1860

ccgggtggtg tctgtgctga ccgtgctgca tcaggattgg ctgaatggca aggaatataa     1920

atgtaaggtg agcaataagg ctctgccggc tagcattgaa aaaaccattt ccaaggctaa     1980

gggccagccc agggagcctc aggtctacac cctgcctcca tctagagatg aactgaccaa     2040

aaaccaggtg agcctgactt gcctggtcaa aggcttctac cccagcgaca ttgccgtgga     2100

gtgggagtct aatggccagc ctgaaaataa ctacaaaact acccctcctg tgctggactc     2160

tgatggctcc ttctttctgt actctaaact gaccgtggac aagtctcgct ggcagcaggg     2220

taacgtgttt tcttgctccg tgctgcacga ggctctgcat aaccattaca cccagaagag     2280

cctgtctctg tccccaggat agaattc                                         2307


<210>  61
<211>  743
<212>  PRT
<213>  AB23P10

<400>  61

Gln Val Gln Leu Gln Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Val Thr Pro Gly Glu Lys Ala Thr Leu Ser Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Ile 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp His Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Glu Ala Glu Asp Val Ala Val Tyr Tyr Cys Phe Gln 
    210                 215                 220                 


Gly Ser Val Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Glu Val Gln Leu 
            260                 265                 270         


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
305                 310                 315                 320 


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
            340                 345                 350         


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
        355                 360                 365             


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro 
                405                 410                 415     


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser 
            420                 425                 430         


Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln 
        435                 440                 445             


Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg 
    450                 455                 460                 


Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
465                 470                 475                 480 


Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                485                 490                 495     


Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr 
            500                 505                 510         


Lys Leu Thr Val Leu Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        515                 520                 525             


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    530                 535                 540                 


Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
545                 550                 555                 560 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                565                 570                 575     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            580                 585                 590         


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        595                 600                 605             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    610                 615                 620                 


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
625                 630                 635                 640 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                645                 650                 655     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            660                 665                 670         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        675                 680                 685             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    690                 695                 700                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
705                 710                 715                 720 


Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                725                 730                 735     


Ser Leu Ser Leu Ser Pro Gly 
            740             


<210>  62
<211>  2307
<212>  DNA
<213>  AB23P10

<400>  62
actagtcgcc accatgagga gcctcggggc cctgctcttg ctgctgagcg cctgcctggc       60

ggtgagcgct caggtgcagc tgcaggagtc cggacctgcc ctggtgaagc caacacagac      120

cctgacactg acctgtacct tctccggctt ctctctgtcc accagcggaa tgggagtggg      180

atggatcagg cagccacctg gcaaggccct ggagtggctg gctcacatct ggtgggacga      240

tgacaagaga tacaacccag ctctgaagtc tcgcctgacc atcagcaagg atacatctaa      300

gaaccaggtg tttctgacca tgacaaatat ggaccccgtg gacaccgcca catactattg      360

cgctcgcatg gagctgtggt cctactattt cgactactgg ggccagggta cactggtcac      420

cgtgagctct ggtggtggtg gttccggcgg cggcggttct ggcggcggcg gcagcgagaa      480

cgtgctgaca cagtctccag ccaccctgtc cgtgacacct ggagagaagg ccaccctgtc      540

ctgttccgct tcttcttccg tgagctacat gcactggtat cagcagaagc caggacaggc      600

tccaaggctg ctgatctacg acacctccaa gctggctagc ggcattcctg ctcggttttc      660

tggttctggc agcggcaccg atcataccct gacaatctcc agcctggagg ctgaagatgt      720

ggctgtctac tattgtttcc agggcagcgt gtatcccttc accttcggcc agggtaccaa      780

gctggagatc aagggtggcg gcggtggagg atccggcggt ggaggtagcg gcggaggcgg      840

tagctccagc tctagtaaag ctccccctcc ttccgaggtg cagctgctgg agtccggagg      900

aggactggtg cagccaggag gctccctgaa gctgagctgt gctgcctctg gctttacctt      960

caacacatat gccatgaatt gggtgcggca ggctccaggc aagggactgg agtgggtggc     1020

taggatcagg tctaagtaca acaattatgc cacctactat gctgattccg tgaaggacag     1080

gttcaccatc tcccgcgacg atagcaagaa cacagcctac ctgcagatga acaatctgaa     1140

gaccgaggat accgccgtgt actactgcgt gagacatggc aactttggca atagctacgt     1200

gtcctggttc gcttactggg gacagggcac cctggtcaca gtgagctctg gaggaggagg     1260

atctggagga ggaggctccg gaggaggagg aagcgagctg gtggtgaccc aggagccatc     1320

tctgacagtg tcccccggcg gcacagtgac cctgacatgt agatccagca ccggcgccgt     1380

gaccacatcc aactacgcta attgggtgca gcagaagcca ggacaggctc caaggggact     1440

gatcggagga accaacaaga gggctcctgg aacaccagct cggtttagcg gatctctgct     1500

gggaggcaag gctgccctga ccctgtccgg agtgcagcca gaggatgagg ccgagtatta     1560

ttgcgctctg tggtatagca atctgtgggt gttcggagga ggaaccaagc tgacagtgct     1620

ggacaagacc catacatgcc caccatgccc tgcccctgaa gccgccggag gaccttccgt     1680

gttcctgttc cctcccaagc caaaagatca gctgatgatc tctagaaccc ccgaagtcac     1740

ctgcgtggtc gtcgacgtgt cccatgagga ccctgaagtc aagttcaact ggtacgtgga     1800

cggtgtcgaa gtccacaacg ccaagaccaa gcctagggag gagcagtatg ccagcacata     1860

ccgggtggtg tctgtgctga ccgtgctgca tcaggattgg ctgaatggca aggaatataa     1920

atgtaaggtg agcaataagg ctctgccggc tagcattgaa aaaaccattt ccaaggctaa     1980

gggccagccc agggagcctc aggtctacac cctgcctcca tctagagatg aactgaccaa     2040

aaaccaggtg agcctgactt gcctggtcaa aggcttctac cccagcgaca ttgccgtgga     2100

gtgggagtct aatggccagc ctgaaaataa ctacaaaact acccctcctg tgctggactc     2160

tgatggctcc ttctttctgt actctaaact gaccgtggac aagtctcgct ggcagcaggg     2220

taacgtgttt tcttgctccg tgctgcacga ggctctgcat aaccattaca cccagaagag     2280

cctgtctctg tccccaggat agaattc                                         2307


<210>  63
<211>  107
<212>  PRT
<213>  CD19_VL

<400>  63

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Val Ala Val Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


