                         SEQUENCE LISTING

<110>  1GLOBE BIOMEDICAL CO., LTD.
       1GLOBE HEALTH INSTITUTE LLC
       LI, Chiang J.
       UNNIRAMAN, Shyam
       BADER, Hannah
       LAU, Alan
 
<120>  NOVEL RATIONALLY DESIGNED PROTEIN COMPOSITIONS

<130>  0902

<150>  US 62/752,293
<151>  2018-10-29

<150>  US 62/811,116
<151>  2019-02-27

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of PDL1 antibody B2 heavy chain

<400>  1
atggagtttg ggctgagctg gctttttctt gtcgcgattc ttaagggtgt ccagtgcgaa       60

gtgcagctgg tggagtctgg gggaggcttg gtacagcctg gagggtccct gagactctcc      120

tgtgcagcct ctggattcac ttttagtgac tatgacatga tctgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tcatatgatg gaagtaataa atactatgca      240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc tgaggacacg gctgtgtatt actgtgcgaa agagttcttt      360

ggtgcttttg atatctgggg ccaagggaca atggtcaccg tctcttcagc ttcgaccaag      420

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      660

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      720

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      840

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      900

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      960

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1020

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1080

cagccccgag aaccacaggt gtacaccctg cccccatccc gcgaggagat gaccaagaac     1140

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1200

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1260

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1380

tccctgtctc cgggtaaatg a                                               1401


<210>  2
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full length protein sequence of PDL1 antibody B2 heavy chain

<400>  2

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Glu Phe Phe Gly Ala Phe Asp Ile Trp Gly Gln 
        115                 120                 125             


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  3
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region protein sequence of PDL1 antibody B2 heavy chain

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Phe Phe Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  4
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of PDL1 antibody B2 light chain

<400>  4
atgacttgga ccccactcct cttcctcacc ctcctcctcc actgcacagg aagcttatcc       60

tcttctgagc tgactcagga ccctgctgtg tcggtggcct tgggacagac agtcacgatc      120

acatgccaag gagacagcct caattactat tatgcaaact ggttccagct gaagccaggg      180

caggcccctg tacttgtcct ctttggtaaa aacaaccggc cctcagggat cccagaccga      240

ttctctggct cctactcggg aagcacagct tccttgacca tcactggggc tcaggcggaa      300

gatgacgctg actattactg taattcgcgg gacagcggtg gtaatccttg ggtgttcggc      360

ggagggacca agctgaccgt cctaggtcaa cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctacctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt catga                      705


<210>  5
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full length protein sequence of PDL1 antibody B2 light chain

<400>  5

Met Thr Trp Thr Pro Leu Leu Phe Leu Thr Leu Leu Leu His Cys Thr 
1               5                   10                  15      


Gly Ser Leu Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
            20                  25                  30          


Ala Leu Gly Gln Thr Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Asn 
        35                  40                  45              


Tyr Tyr Tyr Ala Asn Trp Phe Gln Leu Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Leu Phe Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Tyr Ser Gly Ser Thr Ala Ser Leu Thr Ile Thr Gly 
                85                  90                  95      


Ala Gln Ala Glu Asp Asp Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
            100                 105                 110         


Gly Gly Asn Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region protein sequence of PDL1 antibody B2 light chain

<400>  6

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Asn Tyr Tyr Tyr Ala 
            20                  25                  30          


Asn Trp Phe Gln Leu Lys Pro Gly Gln Ala Pro Val Leu Val Leu Phe 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Gly Ser Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Gly Gly Asn Pro 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  7
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of PDL1 antibody E1 heavy chain

<400>  7
atggagtttg ggctgagctg gctttttctt gtcgcgattc ttaagggtgt ccagtgccaa       60

atccagctgg tacaatctgg ggctgaggtg aagatgcctg gggcctcagt gacgatttcc      120

tgcgaggcgt ctggatacaa cttcatcagc tactatatac actgggtgcg acaggcccct      180

ggacaaggcc ttgagtggat gggattcgtc gtccctagtg gtggtgccgc aggctacaca      240

cagaagttcc agggcagact caccgtgacc agggacacgt ccacgagcac agtctacatg      300

gacctgaaca gcctgacatc tgacgacacg gccgtgtatt actgtgtgcg agaaatgagt      360

ggtggctggt ttgatttctg gggccaggga accctggtca ccgtctcctc ggcttcgacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgcgagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa atga                                            1404


<210>  8
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full length protein sequence of PDL1 antibody E1 heavy chain

<400>  8

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Met 
            20                  25                  30          


Pro Gly Ala Ser Val Thr Ile Ser Cys Glu Ala Ser Gly Tyr Asn Phe 
        35                  40                  45              


Ile Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Phe Val Val Pro Ser Gly Gly Ala Ala Gly Tyr Thr 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Leu Thr Val Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Val Tyr Met Asp Leu Asn Ser Leu Thr Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Arg Glu Met Ser Gly Gly Trp Phe Asp Phe Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  9
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region protein sequence of PDL1 antibody E1 heavy chain

<400>  9

Ser Cys Glu Ala Ser Gly Tyr Asn Phe Ile Ser Tyr Tyr Ile His Trp 
1               5                   10                  15      


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Phe Val Val 
            20                  25                  30          


Pro Ser Gly Gly Ala Ala Gly Tyr Thr Gln Lys Phe Gln Gly Arg Leu 
        35                  40                  45              


Thr Val Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Asp Leu Asn 
    50                  55                  60                  


Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val Arg Glu Met 
65                  70                  75                  80  


Ser Gly Gly Trp Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val 
                85                  90                  95      


Ser Ser 
        


<210>  10
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of PDL1 antibody E1 light chain

<400>  10
atggacatgc gcgtgcccgc ccagctgctg ggcctgctgc tgctgtggtt ccccggctcg       60

cgatgcgaca tcgtgatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      120

gtcaccatca cttgccgggc aagtcagggc attagaaatg atttaggctg gtatcagcaa      180

aaaccaggga aagcccctaa gctcctgatc tatgctgcat ccactttgca aagtggggtc      240

ccatcaaggt tcagcggcag tggatctggg acagatttca ctctcaccat cagcagcctg      300

caggctgaag atgtggcagt ttattactgt cagcaatatt atagtactcc tctcactttc      360

ggccctggga ccaaagtgga tatcaaacgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgttg a               711


<210>  11
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full length protein sequence of PDL1 antibody E1 light chain

<400>  11

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region protein sequence of PDL1 antibody E1 light chain

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  13
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of PDL1 antibody E3 heavy chain

<400>  13
atggagtttg ggctgagctg gctttttctt gtcgcgattc ttaagggtgt ccagtgccaa       60

atccagctgg tacaatctgg ggctgaggtg aagaagcctg ggtcctcggt gaaggtctcc      120

tgcaaggctt ctggaggcac cttcagcagc tatgctatca gctgggtgcg acaggcccct      180

ggacaagggc ttgagtggat gggagggatc atccctatct ttggtacagc aaactacgca      240

cagaagttcc agggcagagt cacgattacc gcggacaaat ccacgagcac agcctacatg      300

gagctgagca gcctgagatc tgaggacacg gccgtgtatt actgtgccgg agggggagca      360

gtggcggaca atagttactg gggccaggga accctggtca ccgtctcctc agcttcgacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgcgagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa atga                                            1404


<210>  14
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full length protein sequence of PDL1 antibody E3 heavy chain

<400>  14

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Gly Gly Gly Ala Val Ala Asp Asn Ser Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  15
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region protein sequence of PDL1 antibody E3 heavy chain

<400>  15

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Gly Ala Val Ala Asp Asn Ser Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  16
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of PDL1 antibody E3 light chain

<400>  16
atggacatgc gcgtgcccgc ccagctgctg ggcctgctgc tgctgtggtt ccccggctcg       60

cgatgcgaca tccggatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      120

gtcaccatca cttgccgggc aagtcagggc attagaaatg atttaggctg gtatcagcag      180

aaaccaggga aagcccctaa gctcctgatc tatgctgcat ccagtttaca aagtggggtc      240

ccatcaaggt tcagcggcag tggatctggc acagatttca ctctcaccat cagcagcctg      300

cagcctgaag attttgcaac ttattactgt ctacaagatt acaattaccc tcgaacgttc      360

ggccaaggga ccaaggtgga aatcaaacgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgttg a               711


<210>  17
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full length protein sequence of PDL1 antibody E3 light chain

<400>  17

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Asp Ile Arg Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Asp Tyr Asn Tyr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable region protein sequence of PDL1 antibody E3 light chain

<400>  18

Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ser-Gly linker

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  20
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2WT DNA sequence

<400>  20
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gacccggatg      120

ctgaccttca agttctacat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaagagc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  21
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2WT protein sequence

<400>  21

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  22
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2Del DNA sequence

<400>  22
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac gccaccgagc tgaagcattt acagtgtctg      120

gaggaagagc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      180

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      240

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      300

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      345


<210>  23
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2Del protein sequence

<400>  23

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Ala Thr 
            20                  25                  30          


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
        35                  40                  45              


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
    50                  55                  60                  


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
65                  70                  75                  80  


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
                85                  90                  95      


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
            100                 105                 110         


Leu Thr 
        


<210>  24
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M1: F42K, Y45R DNA sequence

<400>  24
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gacccggatg      120

ctgaccaaga agttccgcat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaagagc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  25
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M1: F42K, Y45R protein sequence

<400>  25

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Lys Lys Phe Arg Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  26
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M2: F42A, Y45R DNA sequence

<400>  26
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gacccggatg      120

ctgaccgcca agttccgcat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaagagc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  27
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M2: F42A, Y45R protein sequence

<400>  27

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Arg Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  28
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M3: E62R DNA sequence

<400>  28
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gacccggatg      120

ctgaccttca agttctacat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaaaggc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  29
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M3: E62R protein sequence

<400>  29

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Arg Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  30
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M4: R38A, F42A DNA sequence

<400>  30
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gaccgccatg      120

ctgaccgcca agttctacat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaagagc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  31
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M4: R38A, F42A protein sequence

<400>  31

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Ala Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  32
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M5: R38A, F42A, Y45A, E62A, C125S DNA sequence

<400>  32
ggagctccta cctcctcctc caccaagaag acccagctcc agctggaaca tttactgctg       60

gatttacaga tgattttaaa cggcatcaac aattacaaga accccaagct gaccgccatg      120

ctgaccgcca agtttgccat gcccaagaag gccaccgagc tgaagcattt acagtgttta      180

gaggaggctt taaagccttt agaggaggtg ctgaatttag cccagtccaa gaacttccat      240

ttaaggcccc gggatttaat ctccaacatc aacgtgatcg tgctggaact gaagggcagc      300

gagaccacct ttatgagcga atacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gtccatcatc tccactttaa cctga                      405


<210>  33
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M5: R38A, F42A, Y45A, E62A, C125S protein sequence

<400>  33

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Ala Lys Phe Ala Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Ala Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Ser Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  34
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M6: R38A, F42K DNA sequence

<400>  34
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gaccgccatg      120

ctgaccaaga agttctacat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaagagc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  35
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M6: R38A, F42K protein sequence

<400>  35

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Lys Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  36
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M7: R38A, F42A, E62R DNA sequence

<400>  36
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gaccgccatg      120

ctgaccgcca agttctacat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaaaggc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  37
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M7: R38A, F42A, E62R Protein sequence

<400>  37

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Ala Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Arg Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  38
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M8: F42K, Y45R, E62R DNA sequence

<400>  38
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gacccggatg      120

ctgaccaaga agttccgcat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaaaggc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  39
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M8: F42K, Y45R, E62R Protein sequence

<400>  39

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Lys Lys Phe Arg Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Arg Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  40
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M9: F42A, Y45R, E62R DNA sequence

<400>  40
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gacccggatg      120

ctgaccgcca agttccgcat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaaaggc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  41
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M9: F42A, Y45R, E62R Protein sequence

<400>  41

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Arg Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Arg Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  42
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M10: R38A, F42K, E62R DNA sequence

<400>  42
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gaccgccatg      120

ctgaccaaga agttctacat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaaaggc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  43
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M10: R38A, F42K, E62R Protein sequence

<400>  43

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Lys Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Arg Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  44
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2DelM3: Del, E62R DNA sequence

<400>  44
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac gccaccgagc tgaagcattt acagtgtctg      120

gaggaaaggc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      180

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      240

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      300

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      345


<210>  45
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2DelM3: Del, E62R Protein sequence

<400>  45

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Ala Thr 
            20                  25                  30          


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Arg Leu Lys Pro Leu Glu 
        35                  40                  45              


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
    50                  55                  60                  


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
65                  70                  75                  80  


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
                85                  90                  95      


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
            100                 105                 110         


Leu Thr 
        


<210>  46
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M3K: E62K DNA sequence

<400>  46
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gacccggatg      120

ctgaccttca agttctacat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaaaagc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  47
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M3K: E62K Protein sequence

<400>  47

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Lys Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  48
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M6K: R38A, F42K, E62K DNA sequence

<400>  48
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gaccgccatg      120

ctgaccaaga agttctacat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaaaagc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  49
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M6K: R38A, F42K, E62K Protein sequence

<400>  49

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Lys Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Lys Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  50
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M7K: R38A, F42A, E62K DNA sequence

<400>  50
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gaccgccatg      120

ctgaccgcca agttctacat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaaaagc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  51
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M7K: R38A, F42A, E62K Protein sequence

<400>  51

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Ala Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Lys Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  52
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M8K: F42K, Y45R, E62K DNA sequence

<400>  52
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gacccggatg      120

ctgaccaaga agttccgcat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaaaagc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  53
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M8K: F42K, Y45R, E62K Protein sequence

<400>  53

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Lys Lys Phe Arg Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Lys Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  54
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2M9K: F42A, Y45R, E62K DNA sequence

<400>  54
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccaagct gacccggatg      120

ctgaccgcca agttccgcat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gaggaaaagc tgaagccttt agaggaagtg ctcaatttag cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  55
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2M9K: F42A, Y45R, E62K Protein sequence

<400>  55

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Arg Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Lys Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  56
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2MNew: K35E R38A F42A E61K L72G DNA sequence

<400>  56
ggcgccccca catcctccag caccaagaag acccagctgc agctggagca tctgctgctg       60

gatctgcaga tgattttaaa cggcatcaac aactacaaga accccgagct gaccgccatg      120

ctgaccgcca agttctacat gcccaagaag gccaccgagc tgaagcattt acagtgtctg      180

gagaaagagc tgaagccttt agaggaagtg ctcaatggcg cccagtccaa gaacttccat      240

ttaaggccac gtgatttaat ctccaacatc aacgtgatcg tgctggagct gaagggctcc      300

gagaccacct tcatgtgcga gtacgccgac gagaccgcca ccatcgtgga gtttttaaat      360

cgttggatca ccttctgcca gagcatcatc tccactttaa cctga                      405


<210>  57
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2MNew: K35E R38A F42A E61K L72G Protein sequence

<400>  57

Gly Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Glu Leu Thr Ala Met Leu Thr Ala Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Lys Glu Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


