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<110>  ԴҽҩƼϺ޹˾
 
<120>  ˫Կ弰;

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  ˹

<400>  1

Asn Tyr Trp Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  ˹

<400>  2

Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  12
<212>  PRT
<213>  ˹

<400>  3

Gly Ala Ile Tyr Asp Gly Tyr Asp Val Leu Asp Asn 
1               5                   10          


<210>  4
<211>  11
<212>  PRT
<213>  ˹

<400>  4

Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  ˹

<400>  5

Tyr Thr Ser Asn Leu His Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  ˹

<400>  6

Gln Gln Tyr Arg Lys Leu Pro Trp Thr 
1               5                   


<210>  7
<211>  121
<212>  PRT
<213>  ˹

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ile Tyr Asp Gly Tyr Asp Val Leu Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  107
<212>  PRT
<213>  ˹

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  28
<212>  PRT
<213>  ˹

<400>  9

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  10
<211>  27
<212>  PRT
<213>  ˹

<400>  10

Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
            20                  25          


<210>  11
<211>  5
<212>  PRT
<213>  ˹

<400>  11

Thr Tyr Ala Met Asn 
1               5   


<210>  12
<211>  19
<212>  PRT
<213>  ˹

<400>  12

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  13
<211>  14
<212>  PRT
<213>  ˹

<400>  13

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  ˹

<400>  14

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  15
<211>  7
<212>  PRT
<213>  ˹

<400>  15

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  ˹

<400>  16

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  17
<211>  125
<212>  PRT
<213>  ˹

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  18
<211>  109
<212>  PRT
<213>  ˹

<400>  18

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  19
<211>  226
<212>  PRT
<213>  ˹

<400>  19

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  20
<211>  764
<212>  PRT
<213>  ˹

<400>  20

Met Arg Ser Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala 
1               5                   10                  15      


Val Ser Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Ala Ile Tyr Asp Gly Tyr Asp Val Leu Asp 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Asn 
        195                 200                 205             


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Tyr Arg Lys Leu Pro Trp Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Ser Ser Ser Ser Lys Ala Pro Pro Pro 
        275                 280                 285             


Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    290                 295                 300                 


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr 
305                 310                 315                 320 


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                325                 330                 335     


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
            340                 345                 350         


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
        355                 360                 365             


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp 
385                 390                 395                 400 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val 
            420                 425                 430         


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
        435                 440                 445             


Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala 
    450                 455                 460                 


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
465                 470                 475                 480 


Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
                485                 490                 495     


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
            500                 505                 510         


Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val 
        515                 520                 525             


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Asp Lys Thr His Thr Cys 
    530                 535                 540                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
545                 550                 555                 560 


Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu 
                565                 570                 575     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            580                 585                 590         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        595                 600                 605             


Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
    610                 615                 620                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
625                 630                 635                 640 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                645                 650                 655     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            660                 665                 670         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        675                 680                 685             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    690                 695                 700                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
705                 710                 715                 720 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                725                 730                 735     


Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn 
            740                 745                 750         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        755                 760                 


<210>  21
<211>  2313
<212>  DNA
<213>  ˹

<400>  21
actagtcgcc accatgagga gcctcggggc cctgctcttg ctgctgagcg cctgcctggc       60

ggtgagcgct caggtgcagc tggtgcagtc tggcgctgag gtgaagaagc ccggcagctc      120

tgtgaaggtg tcttgtaagg cctccggcgg caccttctcc aactattgga tgcattgggt      180

gcgccaggct cctggccagg gcctggagtg gatgggagct acctacaggg gacactccga      240

cacatattac aatcagaagt ttaagggcag ggtgacaatc accgctgata agtctacatc      300

caccgcctac atggagctgt ccagcctgcg gagcgaggac accgccgtgt attactgcgc      360

cagaggcgct atctacgatg gctatgacgt gctggataac tggggccagg gcacactggt      420

gaccgtgtct tccggaggag gaggatctgg aggaggaggc tccggaggag gaggaagcga      480

tatccagatg acccagagcc caagctctct gtccgcctct gtgggcgata gggtgacaat      540

cacctgttcc gccagccagg acatctctaa ctacctgaat tggtatcagc agaagcccgg      600

caaggctcct aagctgctga tctattacac cagcaatctg cattctggag tgccttcccg      660

cttctctggc tccggaagcg gaacagactt tacactgacc atctccagcc tgcagccaga      720

ggatttcgcc acttactact gccagcagta caggaagctg ccctggacct ttggccaggg      780

taccaagctg gagatcaagg gtggcggcgg tggaggatcc ggcggtggag gtagcggcgg      840

aggcggtagc tccagctcta gtaaagctcc ccctccttcc gaggtgcagc tgctggagtc      900

cggaggagga ctggtgcagc caggaggctc cctgaagctg agctgtgctg cctctggctt      960

taccttcaac acatatgcca tgaattgggt gcggcaggct ccaggcaagg gactggagtg     1020

ggtggctagg atcaggtcta agtacaacaa ttatgccacc tactatgctg attccgtgaa     1080

ggacaggttc accatctccc gcgacgatag caagaacaca gcctacctgc agatgaacaa     1140

tctgaagacc gaggataccg ccgtgtacta ctgcgtgaga catggcaact ttggcaatag     1200

ctacgtgtcc tggttcgctt actggggaca gggcaccctg gtcacagtga gctctggagg     1260

aggaggatct ggaggaggag gctccggagg aggaggaagc gagctggtgg tgacccagga     1320

gccatctctg acagtgtccc ccggcggcac agtgaccctg acatgtagat ccagcaccgg     1380

cgccgtgacc acatccaact acgctaattg ggtgcagcag aagccaggac aggctccaag     1440

gggactgatc ggaggaacca acaagagggc tcctggaaca ccagctcggt ttagcggatc     1500

tctgctggga ggcaaggctg ccctgaccct gtccggagtg cagccagagg atgaggccga     1560

gtattattgc gctctgtggt atagcaatct gtgggtgttc ggaggaggaa ccaagctgac     1620

agtgctggac aagacccata catgcccacc atgccctgcc cctgaagccg ccggaggacc     1680

ttccgtgttc ctgttccctc ccaagccaaa agatcagctg atgatctcta gaacccccga     1740

agtcacctgc gtggtcgtcg acgtgtccca tgaggaccct gaagtcaagt tcaactggta     1800

cgtggacggt gtcgaagtcc acaacgccaa gaccaagcct agggaggagc agtatgccag     1860

cacataccgg gtggtgtctg tgctgaccgt gctgcatcag gattggctga atggcaagga     1920

atataaatgt aaggtgagca ataaggctct gccggctagc attgaaaaaa ccatttccaa     1980

ggctaagggc cagcccaggg agcctcaggt ctacaccctg cctccatcta gagatgaact     2040

gaccaaaaac caggtgagcc tgacttgcct ggtcaaaggc ttctacccca gcgacattgc     2100

cgtggagtgg gagtctaatg gccagcctga aaataactac aaaactaccc ctcctgtgct     2160

ggactctgat ggctccttct ttctgtactc taaactgacc gtggacaagt ctcgctggca     2220

gcagggtaac gtgttttctt gctccgtgct gcacgaggct ctgcataacc attacaccca     2280

gaagagcctg tctctgtccc caggatagaa ttc                                  2313


