                         SEQUENCE LISTING

<110>  LumiSTAR Biotechnology, Inc. and the Governors of the 
       University of Alberta
 
<120>  Genetically Encoded Fluorescent Indicators Under Optogenetic 
       Control and Uses Thereof

<130>  88734.1

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  1242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence based on bacterial sequence

<400>  1
atgggcagcg tgaagctgat ccccagcctg accaccgtga tcctcgtgaa gtccatgctg       60

cggaagcgga gcttcggcaa ccccttcaag tataatacgg agaccctgta ccccgctgac      120

ggcggcctgg aaggcgcatg tgacatggcc ctgaagctcg tgggcggggg ccacctgaac      180

tgcagccttg agaccacata cagatccaag aaacccgcta cgaacctcaa gatgcccggt      240

gtctacaacg tggaccacag actggaacga atcaaagagg ccgacgatga gacctacgtc      300

gagctgcacg aggtggctgt ggccagatac gtgggcctgg gtggtggcgg aggtacaggc      360

gggagtgtga gcgagctgat taaggagaac atgccaatga agctgtacat ggagggcacc      420

gtgaacaacc accacttcaa gtgcacatcc gagggcgaag gcaagcccta cgagggcacc      480

cagaccatga gaatcaaggt cgtcgagggc ggccctctcc ccttcgcctt cgacatcctg      540

gctaccagct tcatgtacgg cagcagaacc ttcatcaagc accctcctgg catccccgac      600

ttctttaagc agtccttccc tgagggcttc acatgggaga gagtcaccac atacgaagac      660

gggggcgtgc tgaccgctac ccaggacacc agcctccagg acggctgcct catctacaac      720

gtcaaggtta gagggatgaa cttcccagcc aacggccctg tgatgcagaa gaaaacactc      780

ggctgggagg ccagtaatgg ccaactgact gaagagcaga tcgcagaatt taaagaggct      840

ttctccctat ttgacaagga cggggatggg acgataacaa ccaaggagct ggggacggtg      900

atgcggtctc tggggcagaa ccccacagaa gcggagctgc aggacatgat caatgaagta      960

gatgccgacg gtgacggcac attcgacttc cctgagttcc tgacgatgat ggcaagaaaa     1020

atgagttata gagtcactga agaggaaatt agagaagcgt tccgcgtgtt tgataaggac     1080

ggcaatggct acatcggcgc agcagagctt cgccacgtga tgacagacct tggagagaag     1140

ttaacagatg aggaggttga tgaaatgatc agggtagcag acatcgatgg ggatggtcag     1200

gtaaactacg aagagtttgt acaaatgatg acagcgaagt ag                        1242


<210>  2
<211>  2973
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence based on bacterial sequence

<400>  2
atggactatg gcggcgcttt gtctgccgtc ggacgcgaac ttttgttcgt tactaatcct       60

gtggtggtga acgggtccgt cctggtccct gaggatcaat gttactgtgc cggatggatt      120

gaatctcgcg gcacgaacgg cgctcagacc gcgtcaaatg tcctgcagtg gcttgcagca      180

ggattcagca ttttgctgct gatgttctat gcctaccaaa cctggaaatc tacatgcggc      240

tgggaggaga tctatgtgtg cgccattgaa atggttaagg tgattctcga gttctttttt      300

gagtttaaga atccctctat gctctacctt gccacaggac accgggtgca gtggctgcgc      360

tatgcagagt ggctgctcac ttgtcctgtc atccttatcc acctgagcaa cctcaccggc      420

ctgagcaacg actacagcag gagaaccatg ggactccttg tctcagacat cgggactatc      480

gtgtgggggg ctaccagcgc catggcaacc ggctatgtta aagtcatctt cttttgtctt      540

ggattgtgct atggcgcgaa cacatttttt cacgccgcca aagcatatat cgagggttat      600

catactgtgc caaagggtcg gtgccgccag gtcgtgaccg gcatggcatg gctgtttttc      660

gtgagctggg gtatgttccc aattctcttc attttggggc ccgaaggttt tggcgtcctg      720

agcgtctatg gctccaccgt aggtcacacg attattgatc tgatgagtaa aaattgttgg      780

gggttgttgg gacactacct gcgcgtcctg atccacgagc acatattgat tcacggagat      840

atccgcaaaa ccaccaaact gaacatcggc ggaacggaga tcgaggtcga gactctcgtc      900

gaagacgaag ccgaggccgg agccgtgcca gcggccgcca ccatggtgag caagggcgag      960

gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac     1020

aagttcagcg tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag     1080

ttcatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccttcggc     1140

tacggcctgc agtgcttcgc ccgctacccc gaccacatga agcagcacga cttcttcaag     1200

tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac     1260

tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg     1320

aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac     1380

aacagccaca acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc     1440

aagatccgcc acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac     1500

acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag ctaccagtcc     1560

gccctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc     1620

gccgccggga tcactctcgg catggacgag ctgtacaagg gatccggagc tactaacttc     1680

agcctgctga agcaggctgg agacgtggag gagaaccctg gacctactag tatgggcagc     1740

gtgaagctga tccccagcct gaccaccgtg atcctcgtga agtccatgct gcggaagcgg     1800

agcttcggca accccttcaa gtataatacg gagaccctgt accccgctga cggcggcctg     1860

gaaggcgcat gtgacatggc cctgaagctc gtgggcgggg gccacctgaa ctgcagcctt     1920

gagaccacat acagatccaa gaaacccgct acgaacctca agatgcccgg tgtctacaac     1980

gtggaccaca gactggaacg aatcaaagag gccgacgatg agacctacgt cgagctgcac     2040

gaggtggctg tggccagata cgtgggcctg ggtggtggcg gaggtacagg cgggagtgtg     2100

agcgagctga ttaaggagaa catgccaatg aagctgtaca tggagggcac cgtgaacaac     2160

caccacttca agtgcacatc cgagggcgaa ggcaagccct acgagggcac ccagaccatg     2220

agaatcaagg tcgtcgaggg cggccctctc cccttcgcct tcgacatcct ggctaccagc     2280

ttcatgtacg gcagcagaac cttcatcaag caccctcctg gcatccccga cttctttaag     2340

cagtccttcc ctgagggctt cacatgggag agagtcacca catacgaaga cgggggcgtg     2400

ctgaccgcta cccaggacac cagcctccag gacggctgcc tcatctacaa cgtcaaggtt     2460

agagggatga acttcccagc caacggccct gtgatgcaga agaaaacact cggctgggag     2520

gccagtaatg gccaactgac tgaagagcag atcgcagaat ttaaagaggc tttctcccta     2580

tttgacaagg acggggatgg gacgataaca accaaggagc tggggacggt gatgcggtct     2640

ctggggcaga accccacaga agcggagctg caggacatga tcaatgaagt agatgccgac     2700

ggtgacggca cattcgactt ccctgagttc ctgacgatga tggcaagaaa aatgagttat     2760

agagtcactg aagaggaaat tagagaagcg ttccgcgtgt ttgataagga cggcaatggc     2820

tacatcggcg cagcagagct tcgccacgtg atgacagacc ttggagagaa gttaacagat     2880

gaggaggttg atgaaatgat cagggtagca gacatcgatg gggatggtca ggtaaactac     2940

gaagagtttg tacaaatgat gacagcgaag tag                                  2973


<210>  3
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence based on bacterial sequence

<400>  3
atgtcggtac cgctgactac ctcagcattc ggccacgcgt ttctggctaa ctgtgaacgt       60

gagcagatcc acctggcggg ctccattcag ccgcacggta tcctgctggc tgttaaagag      120

cctgacaacg tggtgatcca ggcttctatt aacgctgcgg agttcctgaa caccaacttt      180

gttgttggcc gtccgctgcg tgacctgggc ggcgatctgc ctttgcagat cctgccgcac      240

ctgaacggcc cgctgcacct ggctccgatg accctgcgtt gtactgtggg ttctccgccg      300

cgtcgtgtgg actgtaccat tcatcgtccg tctaacggcg gcctgatcgt agaactggaa      360

ccagcaacca aggccactaa cattgcgccg gctctggtcg gtgcgcttca tcgtatcact      420

tcttcatcct ccctgatggg cctgtgtgac gaaaccgcga ctattttccg tgagattact      480

ggcttcgacc gtgtgatggt aatgcgtctc ggcgcgcttg acgatctgac tgaagagcag      540

atcgcagaga ttaaagaggc tttctcccta tttgacaagg acggggacgg gacgataaca      600

accaaggagc tggggacggt gttccggtct ctggggcaga accccacaga agcagagctg      660

caggacatga tcaatgaagt agatgccgat ggcgacggca cattcgactt ccctgagttc      720

ctgacgatga tggcaaggaa aatgaatgac tcagacagtg aagaggaaat tagagaagcg      780

ttccgcgtgt ttgataagga cggcaatggc tacatcggcg cagcagagct tcgccacgtg      840

atgacagacc ttggtgagaa gttaactgat gaggaggttg atgaaatgat cagggtagca      900

gacaacgatg gggatggtca ggtaaactac gaagagtttg tacaaatgat gacagcgaag      960

ggtggcggag gttctgtaga ttcatcacgt cgtaagtgga ataaggcagg tcacgcagtc     1020

agagctatag gtcggctgag ctcgcgtagg catgatttgc tgtccgaatg tcgtcgtgcg     1080

gacctggaag cgttcctggg taaccgctac ccggcgtcta ctattccgca gatcgctcgt     1140

cgcctgtacg aacttaaccg tgttcgcctg ctggtagatg tgaactatac tccggttccg     1200

ctacagccgc gcatcagccc gctgaacggt cgtgatctgg atatgtccct gtcttgcctg     1260

cgctctatgt ccccgatcca ccagaaatac atgcaggaca tgggcgttgg cgcaaccctg     1320

gtttgctctc tgatggtgtc tggtcgtctg tggggtctga tcgtttgcca ccactacgaa     1380

ccgcgcttcg ttccgtccca cattcgcgct gctggcgaag cgctggcgga aacttgtgcg     1440

aaccgcatcg cgacgctgga gagctttgca cagtctcagt ccaaatga                  1488


<210>  4
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
atgtcggtac cgctgactac ctcagcattc ggccacgcgt ttctggctaa ctgtgaacgt       60

gagcagatcc acctggcggg ctccattcag ccgcacggta tcctgctggc tgttaaagag      120

cctgacaacg tggtgatcca ggcttctatt aacgctgcgg agttcctgaa caccaacttt      180

gttgttggcc gtccgctgcg tgacctgggc ggcgatctgc ctttgcagat cctgccgcac      240

ctgaacggcc cgctgcacct ggctccgatg accctgcgtt gtactgtggg ttctccgccg      300

cgtcgtgtgg actgtaccat tcatcgaccg tctaacggcg gcctgatcgt agaactggaa      360

ccagcaacca aggccactaa cattgcgccg gctctggtcg gtgcgcttca tcgtatcact      420

tcttcatcct ccctgatggg cctgtgtgac gaaaccgcga ctattttccg tgagattact      480

ggtttcgacc gtgtgatggt aatgcgtctc ggcgcgcttg acgatctgac tgaagagcag      540

atcgcagaga ttaaagaggc tttctcccta tttgacaagg acggggacgg gacgataaca      600

accaaggagc tggggacggt gttccggtct ctggggcaga accccacaga agcagagctg      660

caggacatga tcaatgaagt agatgccgat ggcgacggca tattcgactt ccctgagttc      720

ctgacgatga tggcaaggaa aatgaatgac tcagacagtg aagaggaaat tagaggagcg      780

ttccgcgtgt ttgataagga cggcaatggc tacatcggcg cagcagagct tcgccacgtg      840

atgacagacc ttggtgagaa gttaactgat gaggaggttg atgaaatgat cagggtagca      900

gacaacgatg gggatggtca ggtaaactac gaagagtttg tacaaatgat gacagcgaag      960

ggtggcggag gttctgtaga ttcatcacgt cgtaagtgga ataaggcagg tcacgcagtc     1020

agagctatag gtcggctggg ctcgcgtagg catgatttgc tgtccgaatg tcgtcgtgcg     1080

gacctggaag cgttcctagg taaccgctac ccggcgtcta ctattccgca gatcgctcgt     1140

cgcctgtacg aactcaaccg tgttcgcctg ctggtagatg tgaactatac tccggttccg     1200

ctagagccgc gcatcagccc gctgaacggt cgtgatctgg atatgtccct gtcttgcctg     1260

cgctctatgt ccccgatcca ccagaaatac atgcaggaca tgggcgttgg cgcaaccctg     1320

gtttgctctc tgatggtgtc tggtcgtctg tggggtctga tcgtttgcca ccactacgaa     1380

ccgcgctacg ttccgtccca cattcgcgct gctggcgaag cgctggcgga agcatgtgcg     1440

aaccgcatcg cgacgctgga gagctttgca cagtctcagt ccaaa                     1485


<210>  5
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence based on bacterial sequence

<400>  5

Met Gly Ser Val Lys Leu Ile Pro Ser Leu Thr Thr Val Ile Leu Val 
1               5                   10                  15      


Lys Ser Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Lys Tyr Asn 
            20                  25                  30          


Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Ala Cys Asp 
        35                  40                  45              


Met Ala Leu Lys Leu Val Gly Gly Gly His Leu Asn Cys Ser Leu Glu 
    50                  55                  60                  


Thr Thr Tyr Arg Ser Lys Lys Pro Ala Thr Asn Leu Lys Met Pro Gly 
65                  70                  75                  80  


Val Tyr Asn Val Asp His Arg Leu Glu Arg Ile Lys Glu Ala Asp Asp 
                85                  90                  95      


Glu Thr Tyr Val Glu Leu His Glu Val Ala Val Ala Arg Tyr Val Gly 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Thr Gly Gly Ser Val Ser Glu Leu Ile Lys 
        115                 120                 125             


Glu Asn Met Pro Met Lys Leu Tyr Met Glu Gly Thr Val Asn Asn His 
    130                 135                 140                 


His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr 
145                 150                 155                 160 


Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala 
                165                 170                 175     


Phe Asp Ile Leu Ala Thr Ser Phe Met Tyr Gly Ser Arg Thr Phe Ile 
            180                 185                 190         


Lys His Pro Pro Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu 
        195                 200                 205             


Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu 
    210                 215                 220                 


Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn 
225                 230                 235                 240 


Val Lys Val Arg Gly Met Asn Phe Pro Ala Asn Gly Pro Val Met Gln 
                245                 250                 255     


Lys Lys Thr Leu Gly Trp Glu Ala Ser Asn Gly Gln Leu Thr Glu Glu 
            260                 265                 270         


Gln Ile Ala Glu Phe Lys Glu Ala Phe Ser Leu Phe Asp Lys Asp Gly 
        275                 280                 285             


Asp Gly Thr Ile Thr Thr Lys Glu Leu Gly Thr Val Met Arg Ser Leu 
    290                 295                 300                 


Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met Ile Asn Glu Val 
305                 310                 315                 320 


Asp Ala Asp Gly Asp Gly Thr Phe Asp Phe Pro Glu Phe Leu Thr Met 
                325                 330                 335     


Met Ala Arg Lys Met Ser Tyr Arg Val Thr Glu Glu Glu Ile Arg Glu 
            340                 345                 350         


Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr Ile Gly Ala Ala 
        355                 360                 365             


Glu Leu Arg His Val Met Thr Asp Leu Gly Glu Lys Leu Thr Asp Glu 
    370                 375                 380                 


Glu Val Asp Glu Met Ile Arg Val Ala Asp Ile Asp Gly Asp Gly Gln 
385                 390                 395                 400 


Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr Ala Lys 
                405                 410             


<210>  6
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence based on bacterial sequence

<400>  6

Met Ser Val Pro Leu Thr Thr Ser Ala Phe Gly His Ala Phe Leu Ala 
1               5                   10                  15      


Asn Cys Glu Arg Glu Gln Ile His Leu Ala Gly Ser Ile Gln Pro His 
            20                  25                  30          


Gly Ile Leu Leu Ala Val Lys Glu Pro Asp Asn Val Val Ile Gln Ala 
        35                  40                  45              


Ser Ile Asn Ala Ala Glu Phe Leu Asn Thr Asn Phe Val Val Gly Arg 
    50                  55                  60                  


Pro Leu Arg Asp Leu Gly Gly Asp Leu Pro Leu Gln Ile Leu Pro His 
65                  70                  75                  80  


Leu Asn Gly Pro Leu His Leu Ala Pro Met Thr Leu Arg Cys Thr Val 
                85                  90                  95      


Gly Ser Pro Pro Arg Arg Val Asp Cys Thr Ile His Arg Pro Ser Asn 
            100                 105                 110         


Gly Gly Leu Ile Val Glu Leu Glu Pro Ala Thr Lys Ala Thr Asn Ile 
        115                 120                 125             


Ala Pro Ala Leu Val Gly Ala Leu His Arg Ile Thr Ser Ser Ser Ser 
    130                 135                 140                 


Leu Met Gly Leu Cys Asp Glu Thr Ala Thr Ile Phe Arg Glu Ile Thr 
145                 150                 155                 160 


Gly Phe Asp Arg Val Met Val Met Arg Leu Gly Ala Leu Asp Asp Leu 
                165                 170                 175     


Thr Glu Glu Gln Ile Ala Glu Ile Lys Glu Ala Phe Ser Leu Phe Asp 
            180                 185                 190         


Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu Gly Thr Val Phe 
        195                 200                 205             


Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met Ile 
    210                 215                 220                 


Asn Glu Val Asp Ala Asp Gly Asp Gly Thr Phe Asp Phe Pro Glu Phe 
225                 230                 235                 240 


Leu Thr Met Met Ala Arg Lys Met Asn Asp Ser Asp Ser Glu Glu Glu 
                245                 250                 255     


Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr Ile 
            260                 265                 270         


Gly Ala Ala Glu Leu Arg His Val Met Thr Asp Leu Gly Glu Lys Leu 
        275                 280                 285             


Thr Asp Glu Glu Val Asp Glu Met Ile Arg Val Ala Asp Asn Asp Gly 
    290                 295                 300                 


Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr Ala Lys 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Val Asp Ser Ser Arg Arg Lys Trp Asn Lys Ala 
                325                 330                 335     


Gly His Ala Val Arg Ala Ile Gly Arg Leu Ser Ser Arg Arg His Asp 
            340                 345                 350         


Leu Leu Ser Glu Cys Arg Arg Ala Asp Leu Glu Ala Phe Leu Gly Asn 
        355                 360                 365             


Arg Tyr Pro Ala Ser Thr Ile Pro Gln Ile Ala Arg Arg Leu Tyr Glu 
    370                 375                 380                 


Leu Asn Arg Val Arg Leu Leu Val Asp Val Asn Tyr Thr Pro Val Pro 
385                 390                 395                 400 


Leu Gln Pro Arg Ile Ser Pro Leu Asn Gly Arg Asp Leu Asp Met Ser 
                405                 410                 415     


Leu Ser Cys Leu Arg Ser Met Ser Pro Ile His Gln Lys Tyr Met Gln 
            420                 425                 430         


Asp Met Gly Val Gly Ala Thr Leu Val Cys Ser Leu Met Val Ser Gly 
        435                 440                 445             


Arg Leu Trp Gly Leu Ile Val Cys His His Tyr Glu Pro Arg Phe Val 
    450                 455                 460                 


Pro Ser His Ile Arg Ala Ala Gly Glu Ala Leu Ala Glu Thr Cys Ala 
465                 470                 475                 480 


Asn Arg Ile Ala Thr Leu Glu Ser Phe Ala Gln Ser Gln Ser Lys 
                485                 490                 495 


<210>  7
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence based on bacterial sequence

<400>  7

Met Ser Val Pro Leu Thr Thr Ser Ala Phe Gly His Ala Phe Leu Ala 
1               5                   10                  15      


Asn Cys Glu Arg Glu Gln Ile His Leu Ala Gly Ser Ile Gln Pro His 
            20                  25                  30          


Gly Ile Leu Leu Ala Val Lys Glu Pro Asp Asn Val Val Ile Gln Ala 
        35                  40                  45              


Ser Ile Asn Ala Ala Glu Phe Leu Asn Thr Asn Phe Val Val Gly Arg 
    50                  55                  60                  


Pro Leu Arg Asp Leu Gly Gly Asp Leu Pro Leu Gln Ile Leu Pro His 
65                  70                  75                  80  


Leu Asn Gly Pro Leu His Leu Ala Pro Met Thr Leu Arg Cys Thr Val 
                85                  90                  95      


Gly Ser Pro Pro Arg Arg Val Asp Cys Thr Ile His Arg Pro Ser Asn 
            100                 105                 110         


Gly Gly Leu Ile Val Glu Leu Glu Pro Ala Thr Lys Ala Thr Asn Ile 
        115                 120                 125             


Ala Pro Ala Leu Val Gly Ala Leu His Arg Ile Thr Ser Ser Ser Ser 
    130                 135                 140                 


Leu Met Gly Leu Cys Asp Glu Thr Ala Thr Ile Phe Arg Glu Ile Thr 
145                 150                 155                 160 


Gly Phe Asp Arg Val Met Val Met Arg Leu Gly Ala Leu Asp Asp Leu 
                165                 170                 175     


Thr Glu Glu Gln Ile Ala Glu Ile Lys Glu Ala Phe Ser Leu Phe Asp 
            180                 185                 190         


Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu Gly Thr Val Phe 
        195                 200                 205             


Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met Ile 
    210                 215                 220                 


Asn Glu Val Asp Ala Asp Gly Asp Gly Ile Phe Asp Phe Pro Glu Phe 
225                 230                 235                 240 


Leu Thr Met Met Ala Arg Lys Met Asn Asp Ser Asp Ser Glu Glu Glu 
                245                 250                 255     


Ile Arg Gly Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr Ile 
            260                 265                 270         


Gly Ala Ala Glu Leu Arg His Val Met Thr Asp Leu Gly Glu Lys Leu 
        275                 280                 285             


Thr Asp Glu Glu Val Asp Glu Met Ile Arg Val Ala Asp Asn Asp Gly 
    290                 295                 300                 


Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr Ala Lys 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Val Asp Ser Ser Arg Arg Lys Trp Asn Lys Ala 
                325                 330                 335     


Gly His Ala Val Arg Ala Ile Gly Arg Leu Gly Ser Arg Arg His Asp 
            340                 345                 350         


Leu Leu Ser Glu Cys Arg Arg Ala Asp Leu Glu Ala Phe Leu Gly Asn 
        355                 360                 365             


Arg Tyr Pro Ala Ser Thr Ile Pro Gln Ile Ala Arg Arg Leu Tyr Glu 
    370                 375                 380                 


Leu Asn Arg Val Arg Leu Leu Val Asp Val Asn Tyr Thr Pro Val Pro 
385                 390                 395                 400 


Leu Glu Pro Arg Ile Ser Pro Leu Asn Gly Arg Asp Leu Asp Met Ser 
                405                 410                 415     


Leu Ser Cys Leu Arg Ser Met Ser Pro Ile His Gln Lys Tyr Met Gln 
            420                 425                 430         


Asp Met Gly Val Gly Ala Thr Leu Val Cys Ser Leu Met Val Ser Gly 
        435                 440                 445             


Arg Leu Trp Gly Leu Ile Val Cys His His Tyr Glu Pro Arg Tyr Val 
    450                 455                 460                 


Pro Ser His Ile Arg Ala Ala Gly Glu Ala Leu Ala Glu Ala Cys Ala 
465                 470                 475                 480 


Asn Arg Ile Ala Thr Leu Glu Ser Phe Ala Gln Ser Gln Ser Lys 
                485                 490                 495 


