                         SEQUENCE LISTING

<110>  New York Blood Center, Inc.
       Regents of the University of Minnesota
 
<120>  Subunit Vaccines

<130>  1958427.00298

<150>  US62/751,470
<151>  2018-10-26

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  676
<212>  PRT
<213>  Zika Virus

<400>  1

Val Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp 
1               5                   10                  15      


Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys 
            20                  25                  30          


Tyr Ile Gln Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser 
        35                  40                  45              


Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp 
    50                  55                  60                  


Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His 
65                  70                  75                  80  


His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro 
                85                  90                  95      


Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu 
            100                 105                 110         


Ser Arg Glu Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe 
        115                 120                 125             


Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu 
    130                 135                 140                 


Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu 
145                 150                 155                 160 


Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp 
                165                 170                 175     


Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp Ile Val Leu Glu 
            180                 185                 190         


His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp 
        195                 200                 205             


Ile Glu Leu Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser 
    210                 215                 220                 


Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys 
225                 230                 235                 240 


Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr 
                245                 250                 255     


Val Cys Lys Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
            260                 265                 270         


Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser 
        275                 280                 285             


Lys Lys Met Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg 
    290                 295                 300                 


Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly Met Ile Val Asn 
305                 310                 315                 320 


Asp Thr Gly His Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr 
                325                 330                 335     


Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu 
            340                 345                 350         


Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr 
        355                 360                 365             


Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe 
    370                 375                 380                 


His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro 
385                 390                 395                 400 


His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala 
                405                 410                 415     


Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His 
            420                 425                 430         


Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly 
        435                 440                 445             


Arg Leu Ser Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu 
    450                 455                 460                 


Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe 
465                 470                 475                 480 


Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val 
                485                 490                 495     


Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala 
            500                 505                 510         


Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn 
        515                 520                 525             


Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu 
    530                 535                 540                 


Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys 
545                 550                 555                 560 


Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala 
                565                 570                 575     


Phe Glu Ala Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp 
            580                 585                 590         


Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly 
        595                 600                 605             


Lys Gly Ile His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly 
    610                 615                 620                 


Gly Met Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp 
625                 630                 635                 640 


Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala 
                645                 650                 655     


Leu Gly Gly Val Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val 
            660                 665                 670         


Gly Cys Ser Val 
        675     


<210>  2
<211>  505
<212>  PRT
<213>  Zika Virus

<400>  2

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala Asp 
            500                 505 


<210>  3
<211>  112
<212>  PRT
<213>  Zika Virus

<400>  3

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII M375N/E377T protein

<400>  4

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Asn Leu Thr 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


<210>  5
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII WT-Fc protein

<400>  5

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    130                 135                 140                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
145                 150                 155                 160 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                165                 170                 175     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            180                 185                 190         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        195                 200                 205             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    210                 215                 220                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
225                 230                 235                 240 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                245                 250                 255     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            260                 265                 270         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        275                 280                 285             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    290                 295                 300                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
305                 310                 315                 320 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                325                 330                 335     


Leu Ser Pro Gly Lys 
            340     


<210>  6
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII M375N/E377T-Fc protein

<400>  6

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Asn Leu Thr 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    130                 135                 140                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
145                 150                 155                 160 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                165                 170                 175     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            180                 185                 190         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        195                 200                 205             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    210                 215                 220                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
225                 230                 235                 240 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                245                 250                 255     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            260                 265                 270         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        275                 280                 285             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    290                 295                 300                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
305                 310                 315                 320 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                325                 330                 335     


Leu Ser Pro Gly Lys 
            340     


<210>  7
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII WT-His protein

<400>  7

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


His His His His His His 
        115             


<210>  8
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII M375N/E377T-His protein

<400>  8

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Asn Leu Thr 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


His His His His His His 
        115             


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII A333N protein

<400>  9

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Asn Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII T366N/S368T protein

<400>  10

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Asn Glu Thr Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


<210>  11
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII A333N-Fc protein

<400>  11

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Asn Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    130                 135                 140                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
145                 150                 155                 160 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                165                 170                 175     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            180                 185                 190         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        195                 200                 205             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    210                 215                 220                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
225                 230                 235                 240 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                245                 250                 255     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            260                 265                 270         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        275                 280                 285             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    290                 295                 300                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
305                 310                 315                 320 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                325                 330                 335     


Leu Ser Pro Gly Lys 
            340     


<210>  12
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII T366N/S368T-Fc protein

<400>  12

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Asn Glu Thr Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    130                 135                 140                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
145                 150                 155                 160 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                165                 170                 175     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            180                 185                 190         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        195                 200                 205             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    210                 215                 220                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
225                 230                 235                 240 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                245                 250                 255     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            260                 265                 270         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        275                 280                 285             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    290                 295                 300                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
305                 310                 315                 320 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                325                 330                 335     


Leu Ser Pro Gly Lys 
            340     


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII T309N/A311T protein

<400>  13

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Asn Ala Thr Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


<210>  14
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII T315N/I317T protein

<400>  14

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Asn Lys Thr Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


<210>  15
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII T351N protein

<400>  15

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Asn Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII T369N/N371T protein

<400>  16

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Asn Glu Thr Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII E393N/K395T protein

<400>  17

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asn 
                85                  90                  95      


Lys Thr Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


<210>  18
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII T309N/A311T-Fc protein

<400>  18

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Asn Ala Thr Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    130                 135                 140                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
145                 150                 155                 160 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                165                 170                 175     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            180                 185                 190         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        195                 200                 205             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    210                 215                 220                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
225                 230                 235                 240 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                245                 250                 255     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            260                 265                 270         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        275                 280                 285             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    290                 295                 300                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
305                 310                 315                 320 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                325                 330                 335     


Leu Ser Pro Gly Lys 
            340     


<210>  19
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII T315N/I317T-Fc protein

<400>  19

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Asn Lys Thr Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    130                 135                 140                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
145                 150                 155                 160 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                165                 170                 175     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            180                 185                 190         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        195                 200                 205             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    210                 215                 220                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
225                 230                 235                 240 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                245                 250                 255     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            260                 265                 270         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        275                 280                 285             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    290                 295                 300                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
305                 310                 315                 320 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                325                 330                 335     


Leu Ser Pro Gly Lys 
            340     


<210>  20
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII T351N-Fc protein

<400>  20

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Asn Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    130                 135                 140                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
145                 150                 155                 160 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                165                 170                 175     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            180                 185                 190         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        195                 200                 205             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    210                 215                 220                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
225                 230                 235                 240 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                245                 250                 255     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            260                 265                 270         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        275                 280                 285             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    290                 295                 300                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
305                 310                 315                 320 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                325                 330                 335     


Leu Ser Pro Gly Lys 
            340     


<210>  21
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII T369N/N371T-Fc protein

<400>  21

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Asn Glu Thr Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu 
                85                  90                  95      


Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    130                 135                 140                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
145                 150                 155                 160 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                165                 170                 175     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            180                 185                 190         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        195                 200                 205             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    210                 215                 220                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
225                 230                 235                 240 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                245                 250                 255     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            260                 265                 270         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        275                 280                 285             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    290                 295                 300                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
305                 310                 315                 320 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                325                 330                 335     


Leu Ser Pro Gly Lys 
            340     


<210>  22
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV EDIII E393N/K395T-Fc protein

<400>  22

Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr 
1               5                   10                  15      


Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu 
            20                  25                  30          


Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met 
        35                  40                  45              


Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala 
    50                  55                  60                  


Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu 
65                  70                  75                  80  


Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asn 
                85                  90                  95      


Lys Thr Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys 
            100                 105                 110         


Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    130                 135                 140                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
145                 150                 155                 160 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                165                 170                 175     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            180                 185                 190         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        195                 200                 205             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    210                 215                 220                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
225                 230                 235                 240 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                245                 250                 255     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            260                 265                 270         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        275                 280                 285             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    290                 295                 300                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
305                 310                 315                 320 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                325                 330                 335     


Leu Ser Pro Gly Lys 
            340     


<210>  23
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  23

Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys 
225                 


<210>  24
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Foldon

<400>  24

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  25
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 trimerization motif

<400>  25

Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr 
1               5                   10                  15      


His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Val 
            20                  25                  30          


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZIKV forward primer

<400>  26
ttggtcatga tactgctgat tgc                                               23


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZIKV reverse primer

<400>  27
ccttccacaa agtccctatt gc                                                22


