                         SEQUENCE LISTING

<110>  BRISTOL-MYERS SQUIBB COMPANY
       Banks, Glen
 
<120>  Miniaturized Dystrophins and Uses Thereof

<130>  13187-WO-PCT

<150>  62/749982
<151>  2018-10-24

<160>  166   

<170>  PatentIn version 3.5

<210>  1
<211>  3685
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 


Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     


Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         


Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             


Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 


Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 


Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     


Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         


Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             


Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 


Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 


Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     


Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         


Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             


Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 


Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 


Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     


Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         


Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             


Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             


Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             


His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             


Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             


Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             


Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             


Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             


Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             


Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             


Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             


Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             


Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             


Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             


Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             


Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             


Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             


Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             


Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             


Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             


Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             


Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             


Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             


Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             


Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             


Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             


Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             


Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             


Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             


Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             


Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             


Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Gln Arg  Leu Gln Glu 
    1460                 1465                 1470             


Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             


Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             


His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             


Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             


Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             


Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             


Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             


Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             


Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             


Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             


Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             


Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             


Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             


Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             


Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             


Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             


Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             


Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             


Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             


Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             


Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             


Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             


Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             


Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             


Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             


Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             


Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             


Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             


Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             


Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             


Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             


Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             


Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             


Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             


Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             


Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             


Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             


Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             


Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             


Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             


Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             


Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             


Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             


Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             


Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             


Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             


Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             


Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             


Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             


Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             


Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             


Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             


Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             


Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             


Gln Glu  Gly Pro Phe Asp Val  Gln Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             


Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             


Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             


Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             


Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             


Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             


Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             


Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             


Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             


Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             


Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             


Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             


Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             


Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             


Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             


Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             


Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             


Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             


Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             


Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             


Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             


His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             


Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             


Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             


Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             


Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             


Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             


Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             


Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             


Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             


Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             


Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             


Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             


Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             


Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             


Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             


Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             


Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             


Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             


Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             


Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             


His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             


Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             


Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             


Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             


Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             


Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             


Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             


Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             


Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             


Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             


His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             


Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             


His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             


Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             


Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             


Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             


Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             


Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             


Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             


Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             


Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             


Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             


Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             


Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             


Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             


Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             


Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210>  2
<211>  13957
<212>  DNA
<213>  Homo sapiens

<400>  2
gggattccct cactttcccc ctacaggact cagatctggg aggcaattac cttcggagaa       60

aaacgaatag gaaaaactga agtgttactt tttttaaagc tgctgaagtt tgttggtttc      120

tcattgtttt taagcctact ggagcaataa agtttgaaga acttttacca ggtttttttt      180

atcgctgcct tgatatacac ttttcaaaat gctttggtgg gaagaagtag aggactgtta      240

tgaaagagaa gatgttcaaa agaaaacatt cacaaaatgg gtaaatgcac aattttctaa      300

gtttgggaag cagcatattg agaacctctt cagtgaccta caggatggga ggcgcctcct      360

agacctcctc gaaggcctga cagggcaaaa actgccaaaa gaaaaaggat ccacaagagt      420

tcatgccctg aacaatgtca acaaggcact gcgggttttg cagaacaata atgttgattt      480

agtgaatatt ggaagtactg acatcgtaga tggaaatcat aaactgactc ttggtttgat      540

ttggaatata atcctccact ggcaggtcaa aaatgtaatg aaaaatatca tggctggatt      600

gcaacaaacc aacagtgaaa agattctcct gagctgggtc cgacaatcaa ctcgtaatta      660

tccacaggtt aatgtaatca acttcaccac cagctggtct gatggcctgg ctttgaatgc      720

tctcatccat agtcataggc cagacctatt tgactggaat agtgtggttt gccagcagtc      780

agccacacaa cgactggaac atgcattcaa catcgccaga tatcaattag gcatagagaa      840

actactcgat cctgaagatg ttgataccac ctatccagat aagaagtcca tcttaatgta      900

catcacatca ctcttccaag ttttgcctca acaagtgagc attgaagcca tccaggaagt      960

ggaaatgttg ccaaggccac ctaaagtgac taaagaagaa cattttcagt tacatcatca     1020

aatgcactat tctcaacaga tcacggtcag tctagcacag ggatatgaga gaacttcttc     1080

ccctaagcct cgattcaaga gctatgccta cacacaggct gcttatgtca ccacctctga     1140

ccctacacgg agcccatttc cttcacagca tttggaagct cctgaagaca agtcatttgg     1200

cagttcattg atggagagtg aagtaaacct ggaccgttat caaacagctt tagaagaagt     1260

attatcgtgg cttctttctg ctgaggacac attgcaagca caaggagaga tttctaatga     1320

tgtggaagtg gtgaaagacc agtttcatac tcatgagggg tacatgatgg atttgacagc     1380

ccatcagggc cgggttggta atattctaca attgggaagt aagctgattg gaacaggaaa     1440

attatcagaa gatgaagaaa ctgaagtaca agagcagatg aatctcctaa attcaagatg     1500

ggaatgcctc agggtagcta gcatggaaaa acaaagcaat ttacatagag ttttaatgga     1560

tctccagaat cagaaactga aagagttgaa tgactggcta acaaaaacag aagaaagaac     1620

aaggaaaatg gaggaagagc ctcttggacc tgatcttgaa gacctaaaac gccaagtaca     1680

acaacataag gtgcttcaag aagatctaga acaagaacaa gtcagggtca attctctcac     1740

tcacatggtg gtggtagttg atgaatctag tggagatcac gcaactgctg ctttggaaga     1800

acaacttaag gtattgggag atcgatgggc aaacatctgt agatggacag aagaccgctg     1860

ggttctttta caagacatcc ttctcaaatg gcaacgtctt actgaagaac agtgcctttt     1920

tagtgcatgg ctttcagaaa aagaagatgc agtgaacaag attcacacaa ctggctttaa     1980

agatcaaaat gaaatgttat caagtcttca aaaactggcc gttttaaaag cggatctaga     2040

aaagaaaaag caatccatgg gcaaactgta ttcactcaaa caagatcttc tttcaacact     2100

gaagaataag tcagtgaccc agaagacgga agcatggctg gataactttg cccggtgttg     2160

ggataattta gtccaaaaac ttgaaaagag tacagcacag atttcacagg ctgtcaccac     2220

cactcagcca tcactaacac agacaactgt aatggaaaca gtaactacgg tgaccacaag     2280

ggaacagatc ctggtaaagc atgctcaaga ggaacttcca ccaccacctc cccaaaagaa     2340

gaggcagatt actgtggatt ctgaaattag gaaaaggttg gatgttgata taactgaact     2400

tcacagctgg attactcgct cagaagctgt gttgcagagt cctgaatttg caatctttcg     2460

gaaggaaggc aacttctcag acttaaaaga aaaagtcaat gccatagagc gagaaaaagc     2520

tgagaagttc agaaaactgc aagatgccag cagatcagct caggccctgg tggaacagat     2580

ggtgaatgag ggtgttaatg cagatagcat caaacaagcc tcagaacaac tgaacagccg     2640

gtggatcgaa ttctgccagt tgctaagtga gagacttaac tggctggagt atcagaacaa     2700

catcatcgct ttctataatc agctacaaca attggagcag atgacaacta ctgctgaaaa     2760

ctggttgaaa atccaaccca ccaccccatc agagccaaca gcaattaaaa gtcagttaaa     2820

aatttgtaag gatgaagtca accggctatc aggtcttcaa cctcaaattg aacgattaaa     2880

aattcaaagc atagccctga aagagaaagg acaaggaccc atgttcctgg atgcagactt     2940

tgtggccttt acaaatcatt ttaagcaagt cttttctgat gtgcaggcca gagagaaaga     3000

gctacagaca atttttgaca ctttgccacc aatgcgctat caggagacca tgagtgccat     3060

caggacatgg gtccagcagt cagaaaccaa actctccata cctcaactta gtgtcaccga     3120

ctatgaaatc atggagcaga gactcgggga attgcaggct ttacaaagtt ctctgcaaga     3180

gcaacaaagt ggcctatact atctcagcac cactgtgaaa gagatgtcga agaaagcgcc     3240

ctctgaaatt agccggaaat atcaatcaga atttgaagaa attgagggac gctggaagaa     3300

gctctcctcc cagctggttg agcattgtca aaagctagag gagcaaatga ataaactccg     3360

aaaaattcag aatcacatac aaaccctgaa gaaatggatg gctgaagttg atgtttttct     3420

gaaggaggaa tggcctgccc ttggggattc agaaattcta aaaaagcagc tgaaacagtg     3480

cagactttta gtcagtgata ttcagacaat tcagcccagt ctaaacagtg tcaatgaagg     3540

tgggcagaag ataaagaatg aagcagagcc agagtttgct tcgagacttg agacagaact     3600

caaagaactt aacactcagt gggatcacat gtgccaacag gtctatgcca gaaaggaggc     3660

cttgaaggga ggtttggaga aaactgtaag cctccagaaa gatctatcag agatgcacga     3720

atggatgaca caagctgaag aagagtatct tgagagagat tttgaatata aaactccaga     3780

tgaattacag aaagcagttg aagagatgaa gagagctaaa gaagaggccc aacaaaaaga     3840

agcgaaagtg aaactcctta ctgagtctgt aaatagtgtc atagctcaag ctccacctgt     3900

agcacaagag gccttaaaaa aggaacttga aactctaacc accaactacc agtggctctg     3960

cactaggctg aatgggaaat gcaagacttt ggaagaagtt tgggcatgtt ggcatgagtt     4020

attgtcatac ttggagaaag caaacaagtg gctaaatgaa gtagaattta aacttaaaac     4080

cactgaaaac attcctggcg gagctgagga aatctctgag gtgctagatt cacttgaaaa     4140

tttgatgcga cattcagagg ataacccaaa tcagattcgc atattggcac agaccctaac     4200

agatggcgga gtcatggatg agctaatcaa tgaggaactt gagacattta attctcgttg     4260

gagggaacta catgaagagg ctgtaaggag gcaaaagttg cttgaacaga gcatccagtc     4320

tgcccaggag actgaaaaat ccttacactt aatccaggag tccctcacat tcattgacaa     4380

gcagttggca gcttatattg cagacaaggt ggacgcagct caaatgcctc aggaagccca     4440

gaaaatccaa tctgatttga caagtcatga gatcagttta gaagaaatga agaaacataa     4500

tcaggggaag gaggctgccc aaagagtcct gtctcagatt gatgttgcac agaaaaaatt     4560

acaagatgtc tccatgaagt ttcgattatt ccagaaacca gccaattttg agctgcgtct     4620

acaagaaagt aagatgattt tagatgaagt gaagatgcac ttgcctgcat tggaaacaaa     4680

gagtgtggaa caggaagtag tacagtcaca gctaaatcat tgtgtgaact tgtataaaag     4740

tctgagtgaa gtgaagtctg aagtggaaat ggtgataaag actggacgtc agattgtaca     4800

gaaaaagcag acggaaaatc ccaaagaact tgatgaaaga gtaacagctt tgaaattgca     4860

ttataatgag ctgggagcaa aggtaacaga aagaaagcaa cagttggaga aatgcttgaa     4920

attgtcccgt aagatgcgaa aggaaatgaa tgtcttgaca gaatggctgg cagctacaga     4980

tatggaattg acaaagagat cagcagttga aggaatgcct agtaatttgg attctgaagt     5040

tgcctgggga aaggctactc aaaaagagat tgagaaacag aaggtgcacc tgaagagtat     5100

cacagaggta ggagaggcct tgaaaacagt tttgggcaag aaggagacgt tggtggaaga     5160

taaactcagt cttctgaata gtaactggat agctgtcacc tcccgagcag aagagtggtt     5220

aaatcttttg ttggaatacc agaaacacat ggaaactttt gaccagaatg tggaccacat     5280

cacaaagtgg atcattcagg ctgacacact tttggatgaa tcagagaaaa agaaacccca     5340

gcaaaaagaa gacgtgctta agcgtttaaa ggcagaactg aatgacatac gcccaaaggt     5400

ggactctaca cgtgaccaag cagcaaactt gatggcaaac cgcggtgacc actgcaggaa     5460

attagtagag ccccaaatct cagagctcaa ccatcgattt gcagccattt cacacagaat     5520

taagactgga aaggcctcca ttcctttgaa ggaattggag cagtttaact cagatataca     5580

aaaattgctt gaaccactgg aggctgaaat tcagcagggg gtgaatctga aagaggaaga     5640

cttcaataaa gatatgaatg aagacaatga gggtactgta aaagaattgt tgcaaagagg     5700

agacaactta caacaaagaa tcacagatga gagaaagaga gaggaaataa agataaaaca     5760

gcagctgtta cagacaaaac ataatgctct caaggatttg aggtctcaaa gaagaaaaaa     5820

ggctctagaa atttctcatc agtggtatca gtacaagagg caggctgatg atctcctgaa     5880

atgcttggat gacattgaaa aaaaattagc cagcctacct gagcccagag atgaaaggaa     5940

aataaaggaa attgatcggg aattgcagaa gaagaaagag gagctgaatg cagtgcgtag     6000

gcaagctgag ggcttgtctg aggatggggc cgcaatggca gtggagccaa ctcagatcca     6060

gctcagcaag cgctggcggg aaattgagag caaatttgct cagtttcgaa gactcaactt     6120

tgcacaaatt cacactgtcc gtgaagaaac gatgatggtg atgactgaag acatgccttt     6180

ggaaatttct tatgtgcctt ctacttattt gactgaaatc actcatgtct cacaagccct     6240

attagaagtg gaacaacttc tcaatgctcc tgacctctgt gctaaggact ttgaagatct     6300

ctttaagcaa gaggagtctc tgaagaatat aaaagatagt ctacaacaaa gctcaggtcg     6360

gattgacatt attcatagca agaagacagc agcattgcaa agtgcaacgc ctgtggaaag     6420

ggtgaagcta caggaagctc tctcccagct tgatttccaa tgggaaaaag ttaacaaaat     6480

gtacaaggac cgacaagggc gatttgacag atctgttgag aaatggcggc gttttcatta     6540

tgatataaag atatttaatc agtggctaac agaagctgaa cagtttctca gaaagacaca     6600

aattcctgag aattgggaac atgctaaata caaatggtat cttaaggaac tccaggatgg     6660

cattgggcag cggcaaactg ttgtcagaac attgaatgca actggggaag aaataattca     6720

gcaatcctca aaaacagatg ccagtattct acaggaaaaa ttgggaagcc tgaatctgcg     6780

gtggcaggag gtctgcaaac agctgtcaga cagaaaaaag aggctagaag aacaaaagaa     6840

tatcttgtca gaatttcaaa gagatttaaa tgaatttgtt ttatggttgg aggaagcaga     6900

taacattgct agtatcccac ttgaacctgg aaaagagcag caactaaaag aaaagcttga     6960

gcaagtcaag ttactggtgg aagagttgcc cctgcgccag ggaattctca aacaattaaa     7020

tgaaactgga ggacccgtgc ttgtaagtgc tcccataagc ccagaagagc aagataaact     7080

tgaaaataag ctcaagcaga caaatctcca gtggataaag gtttccagag ctttacctga     7140

gaaacaagga gaaattgaag ctcaaataaa agaccttggg cagcttgaaa aaaagcttga     7200

agaccttgaa gagcagttaa atcatctgct gctgtggtta tctcctatta ggaatcagtt     7260

ggaaatttat aaccaaccaa accaagaagg accatttgac gttcaggaaa ctgaaatagc     7320

agttcaagct aaacaaccgg atgtggaaga gattttgtct aaagggcagc atttgtacaa     7380

ggaaaaacca gccactcagc cagtgaagag gaagttagaa gatctgagct ctgagtggaa     7440

ggcggtaaac cgtttacttc aagagctgag ggcaaagcag cctgacctag ctcctggact     7500

gaccactatt ggagcctctc ctactcagac tgttactctg gtgacacaac ctgtggttac     7560

taaggaaact gccatctcca aactagaaat gccatcttcc ttgatgttgg aggtacctgc     7620

tctggcagat ttcaaccggg cttggacaga acttaccgac tggctttctc tgcttgatca     7680

agttataaaa tcacagaggg tgatggtggg tgaccttgag gatatcaacg agatgatcat     7740

caagcagaag gcaacaatgc aggatttgga acagaggcgt ccccagttgg aagaactcat     7800

taccgctgcc caaaatttga aaaacaagac cagcaatcaa gaggctagaa caatcattac     7860

ggatcgaatt gaaagaattc agaatcagtg ggatgaagta caagaacacc ttcagaaccg     7920

gaggcaacag ttgaatgaaa tgttaaagga ttcaacacaa tggctggaag ctaaggaaga     7980

agctgagcag gtcttaggac aggccagagc caagcttgag tcatggaagg agggtcccta     8040

tacagtagat gcaatccaaa agaaaatcac agaaaccaag cagttggcca aagacctccg     8100

ccagtggcag acaaatgtag atgtggcaaa tgacttggcc ctgaaacttc tccgggatta     8160

ttctgcagat gataccagaa aagtccacat gataacagag aatatcaatg cctcttggag     8220

aagcattcat aaaagggtga gtgagcgaga ggctgctttg gaagaaactc atagattact     8280

gcaacagttc cccctggacc tggaaaagtt tcttgcctgg cttacagaag ctgaaacaac     8340

tgccaatgtc ctacaggatg ctacccgtaa ggaaaggctc ctagaagact ccaagggagt     8400

aaaagagctg atgaaacaat ggcaagacct ccaaggtgaa attgaagctc acacagatgt     8460

ttatcacaac ctggatgaaa acagccaaaa aatcctgaga tccctggaag gttccgatga     8520

tgcagtcctg ttacaaagac gtttggataa catgaacttc aagtggagtg aacttcggaa     8580

aaagtctctc aacattaggt cccatttgga agccagttct gaccagtgga agcgtctgca     8640

cctttctctg caggaacttc tggtgtggct acagctgaaa gatgatgaat taagccggca     8700

ggcacctatt ggaggcgact ttccagcagt tcagaagcag aacgatgtac atagggcctt     8760

caagagggaa ttgaaaacta aagaacctgt aatcatgagt actcttgaga ctgtacgaat     8820

atttctgaca gagcagcctt tggaaggact agagaaactc taccaggagc ccagagagct     8880

gcctcctgag gagagagccc agaatgtcac tcggcttcta cgaaagcagg ctgaggaggt     8940

caatactgag tgggaaaaat tgaacctgca ctccgctgac tggcagagaa aaatagatga     9000

gacccttgaa agactccagg aacttcaaga ggccacggat gagctggacc tcaagctgcg     9060

ccaagctgag gtgatcaagg gatcctggca gcccgtgggc gatctcctca ttgactctct     9120

ccaagatcac ctcgagaaag tcaaggcact tcgaggagaa attgcgcctc tgaaagagaa     9180

cgtgagccac gtcaatgacc ttgctcgcca gcttaccact ttgggcattc agctctcacc     9240

gtataacctc agcactctgg aagacctgaa caccagatgg aagcttctgc aggtggccgt     9300

cgaggaccga gtcaggcagc tgcatgaagc ccacagggac tttggtccag catctcagca     9360

ctttctttcc acgtctgtcc agggtccctg ggagagagcc atctcgccaa acaaagtgcc     9420

ctactatatc aaccacgaga ctcaaacaac ttgctgggac catcccaaaa tgacagagct     9480

ctaccagtct ttagctgacc tgaataatgt cagattctca gcttatagga ctgccatgaa     9540

actccgaaga ctgcagaagg ccctttgctt ggatctcttg agcctgtcag ctgcatgtga     9600

tgccttggac cagcacaacc tcaagcaaaa tgaccagccc atggatatcc tgcagattat     9660

taattgtttg accactattt atgaccgcct ggagcaagag cacaacaatt tggtcaacgt     9720

ccctctctgc gtggatatgt gtctgaactg gctgctgaat gtttatgata cgggacgaac     9780

agggaggatc cgtgtcctgt cttttaaaac tggcatcatt tccctgtgta aagcacattt     9840

ggaagacaag tacagatacc ttttcaagca agtggcaagt tcaacaggat tttgtgacca     9900

gcgcaggctg ggcctccttc tgcatgattc tatccaaatt ccaagacagt tgggtgaagt     9960

tgcatccttt gggggcagta acattgagcc aagtgtccgg agctgcttcc aatttgctaa    10020

taataagcca gagatcgaag cggccctctt cctagactgg atgagactgg aaccccagtc    10080

catggtgtgg ctgcccgtcc tgcacagagt ggctgctgca gaaactgcca agcatcaggc    10140

caaatgtaac atctgcaaag agtgtccaat cattggattc aggtacagga gtctaaagca    10200

ctttaattat gacatctgcc aaagctgctt tttttctggt cgagttgcaa aaggccataa    10260

aatgcactat cccatggtgg aatattgcac tccgactaca tcaggagaag atgttcgaga    10320

ctttgccaag gtactaaaaa acaaatttcg aaccaaaagg tattttgcga agcatccccg    10380

aatgggctac ctgccagtgc agactgtctt agagggggac aacatggaaa ctcccgttac    10440

tctgatcaac ttctggccag tagattctgc gcctgcctcg tcccctcagc tttcacacga    10500

tgatactcat tcacgcattg aacattatgc tagcaggcta gcagaaatgg aaaacagcaa    10560

tggatcttat ctaaatgata gcatctctcc taatgagagc atagatgatg aacatttgtt    10620

aatccagcat tactgccaaa gtttgaacca ggactccccc ctgagccagc ctcgtagtcc    10680

tgcccagatc ttgatttcct tagagagtga ggaaagaggg gagctagaga gaatcctagc    10740

agatcttgag gaagaaaaca ggaatctgca agcagaatat gaccgtctaa agcagcagca    10800

cgaacataaa ggcctgtccc cactgccgtc ccctcctgaa atgatgccca cctctcccca    10860

gagtccccgg gatgctgagc tcattgctga ggccaagcta ctgcgtcaac acaaaggccg    10920

cctggaagcc aggatgcaaa tcctggaaga ccacaataaa cagctggagt cacagttaca    10980

caggctaagg cagctgctgg agcaacccca ggcagaggcc aaagtgaatg gcacaacggt    11040

gtcctctcct tctacctctc tacagaggtc cgacagcagt cagcctatgc tgctccgagt    11100

ggttggcagt caaacttcgg actccatggg tgaggaagat cttctcagtc ctccccagga    11160

cacaagcaca gggttagagg aggtgatgga gcaactcaac aactccttcc ctagttcaag    11220

aggaagaaat acccctggaa agccaatgag agaggacaca atgtaggaag tcttttccac    11280

atggcagatg atttgggcag agcgatggag tccttagtat cagtcatgac agatgaagaa    11340

ggagcagaat aaatgtttta caactcctga ttcccgcatg gtttttataa tattcataca    11400

acaaagagga ttagacagta agagtttaca agaaataaat ctatattttt gtgaagggta    11460

gtggtattat actgtagatt tcagtagttt ctaagtctgt tattgttttg ttaacaatgg    11520

caggttttac acgtctatgc aattgtacaa aaaagttata agaaaactac atgtaaaatc    11580

ttgatagcta aataacttgc catttcttta tatggaacgc attttgggtt gtttaaaaat    11640

ttataacagt tataaagaaa gattgtaaac taaagtgtgc tttataaaaa aaagttgttt    11700

ataaaaaccc ctaaaaacaa aacaaacaca cacacacaca catacacaca cacacacaaa    11760

actttgaggc agcgcattgt tttgcatcct tttggcgtga tatccatatg aaattcatgg    11820

ctttttcttt ttttgcatat taaagataag acttcctcta ccaccacacc aaatgactac    11880

tacacactgc tcatttgaga actgtcagct gagtggggca ggcttgagtt ttcatttcat    11940

atatctatat gtctataagt atataaatac tatagttata tagataaaga gatacgaatt    12000

tctatagact gactttttcc attttttaaa tgttcatgtc acatcctaat agaaagaaat    12060

tacttctagt cagtcatcca ggcttacctg cttggtctag aatggatttt tcccggagcc    12120

ggaagccagg aggaaactac accacactaa aacattgtct acagctccag atgtttctca    12180

ttttaaacaa ctttccactg acaacgaaag taaagtaaag tattggattt ttttaaaggg    12240

aacatgtgaa tgaatacaca ggacttatta tatcagagtg agtaatcggt tggttggttg    12300

attgattgat tgattgatac attcagcttc ctgctgctag caatgccacg atttagattt    12360

aatgatgctt cagtggaaat caatcagaag gtattctgac cttgtgaaca tcagaaggta    12420

ttttttaact cccaagcagt agcaggacga tgatagggct ggagggctat ggattcccag    12480

cccatccctg tgaaggagta ggccactctt taagtgaagg attggatgat tgttcataat    12540

acataaagtt ctctgtaatt acaactaaat tattatgccc tcttctcaca gtcaaaagga    12600

actgggtggt ttggtttttg ttgctttttt agatttattg tcccatgtgg gatgagtttt    12660

taaatgccac aagacataat ttaaaataaa taaactttgg gaaaaggtgt aagacagtag    12720

ccccatcaca tttgtgatac tgacaggtat caacccagaa gcccatgaac tgtgtttcca    12780

tcctttgcat ttctctgcga gtagttccac acaggtttgt aagtaagtaa gaaagaaggc    12840

aaattgattc aaatgttaca aaaaaaccct tcttggtgga ttagacaggt taaatatata    12900

aacaaacaaa caaaaattgc tcaaaaaaga ggagaaaagc tcaagaggaa aagctaagga    12960

ctggtaggaa aaagctttac tctttcatgc cattttattt ctttttgatt tttaaatcat    13020

tcattcaata gataccaccg tgtgacctat aattttgcaa atctgttacc tctgacatca    13080

agtgtaatta gcttttggag agtgggctga catcaagtgt aattagcttt tggagagtgg    13140

gttttgtcca ttattaataa ttaattaatt aacatcaaac acggcttctc atgctatttc    13200

tacctcactt tggttttggg gtgttcctga taattgtgca cacctgagtt cacagcttca    13260

ccacttgtcc attgcgttat tttctttttc ctttataatt ctttcttttt ccttcataat    13320

tttcaaaaga aaacccaaag ctctaaggta acaaattacc aaattacatg aagatttggt    13380

ttttgtcttg catttttttc ctttatgtga cgctggacct tttctttacc caaggatttt    13440

taaaactcag atttaaaaca aggggttact ttacatccta ctaagaagtt taagtaagta    13500

agtttcattc taaaatcaga ggtaaataga gtgcataaat aattttgttt taatcttttt    13560

gtttttcttt tagacacatt agctctggag tgagtctgtc ataatatttg aacaaaaatt    13620

gagagcttta ttgctgcatt ttaagcataa ttaatttgga cattatttcg tgttgtgttc    13680

tttataacca ccgagtatta aactgtaaat cataatgtaa ctgaagcata aacatcacat    13740

ggcatgtttt gtcattgttt tcaggtactg agttcttact tgagtatcat aatatattgt    13800

gttttaacac caacactgta acatttacga attatttttt taaacttcag ttttactgca    13860

ttttcacaac atatcagact tcaccaaata tatgccttac tattgtatta tagtactgct    13920

ttactgtgta tctcaataaa gcacgcagtt atgttac                             13957


<210>  3
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu 
                245                 250         


<210>  4
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Pro Arg Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu 
1               5                   10                  15      


His His Gln Met His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln 
            20                  25                  30          


Gly Tyr Glu Arg Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala 
        35                  40                  45              


Tyr Thr Gln Ala Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro 
    50                  55                  60                  


Phe Pro Ser Gln His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser 
65                  70                  75                  80  


Ser Leu Met Glu Ser 
                85  


<210>  5
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu Ser 
1               5                   10                  15      


Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile Ser 
            20                  25                  30          


Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly Tyr 
        35                  40                  45              


Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu Gln 
    50                  55                  60                  


Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu Glu 
65                  70                  75                  80  


Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu Cys 
                85                  90                  95      


Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His 
            100                 105                 


<210>  6
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Val Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp 
1               5                   10                  15      


Trp Leu Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro 
            20                  25                  30          


Leu Gly Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys 
        35                  40                  45              


Val Leu Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu 
    50                  55                  60                  


Thr His Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr 
65                  70                  75                  80  


Ala Ala Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn 
                85                  90                  95      


Ile Cys Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile 
            100                 105                 110     


<210>  7
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala 
1               5                   10                  15      


Trp Leu Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly 
            20                  25                  30          


Phe Lys Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val 
        35                  40                  45              


Leu Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr 
    50                  55                  60                  


Ser Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr 
65                  70                  75                  80  


Gln Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn 
                85                  90                  95      


Leu Val Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala 
            100                 105                 110     


<210>  8
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Thr Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr 
1               5                   10                  15      


Val Thr Thr Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln 
            20                  25                  30          


Glu Glu Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val 
        35                  40                  45              


Asp 
    


<210>  9
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Glu Ile Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser 
1               5                   10                  15      


Trp Ile Thr Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile 
            20                  25                  30          


Phe Arg Lys Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala 
        35                  40                  45              


Ile Glu Arg Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser 
    50                  55                  60                  


Arg Ser Ala Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn 
65                  70                  75                  80  


Ala Asp Ser Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile 
                85                  90                  95      


Glu Phe Cys Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr 
            100                 105                 110     


<210>  10
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Asn Asn Ile Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln 
1               5                   10                  15      


Met Thr Thr Thr Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro 
            20                  25                  30          


Ser Glu Pro Thr Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu 
        35                  40                  45              


Val Asn Arg Leu Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile 
    50                  55                  60                  


Gln Ser Ile Ala Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp 
65                  70                  75                  80  


Ala Asp Phe Val Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp 
                85                  90                  95      


Val Gln Ala Arg Glu Lys Glu Leu Gln Thr Ile Phe Asp 
            100                 105                 


<210>  11
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  11

Thr Leu Pro Pro Met Arg Tyr Gln Glu Thr Met Ser Ala Ile Arg Thr 
1               5                   10                  15      


Trp Val Gln Gln Ser Glu Thr Lys Leu Ser Ile Pro Gln Leu Ser Val 
            20                  25                  30          


Thr Asp Tyr Glu Ile Met Glu Gln Arg Leu Gly Glu Leu Gln Ala Leu 
        35                  40                  45              


Gln Ser Ser Leu Gln Glu Gln Gln Ser Gly Leu Tyr Tyr Leu Ser Thr 
    50                  55                  60                  


Thr Val Lys Glu Met Ser Lys Lys Ala Pro Ser Glu Ile Ser Arg Lys 
65                  70                  75                  80  


Tyr Gln Ser Glu Phe Glu Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser 
                85                  90                  95      


Ser Gln Leu Val Glu His Cys Gln Lys Leu Glu Glu Gln 
            100                 105                 


<210>  12
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asn Lys Leu Arg Lys Ile Gln Asn His Ile Gln Thr Leu Lys Lys 
1               5                   10                  15      


Trp Met Ala Glu Val Asp Val Phe Leu Lys Glu Glu Trp Pro Ala Leu 
            20                  25                  30          


Gly Asp Ser Glu Ile Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu 
        35                  40                  45              


Val Ser Asp Ile Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu 
    50                  55                  60                  


Gly Gly Gln Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg 
65                  70                  75                  80  


Leu Glu Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys 
                85                  90                  95      


Gln Gln Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly 
            100                 105                 


<210>  13
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Glu Lys Thr Val Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu 
1               5                   10                  15      


Trp Met Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr 
            20                  25                  30          


Lys Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala 
        35                  40                  45              


Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu Leu Thr Glu 
    50                  55                  60                  


Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala Gln Glu Ala 
65                  70                  75                  80  


Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln Trp Leu Cys 
                85                  90                  95      


Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu Val 
            100                 105                 


<210>  14
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  14

Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala Asn Lys 
1               5                   10                  15      


Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu Asn Ile Pro 
            20                  25                  30          


Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser Leu Glu Asn Leu 
        35                  40                  45              


Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile Arg Ile Leu Ala Gln 
    50                  55                  60                  


Thr Leu Thr Asp Gly Gly Val Met Asp Glu Leu Ile Asn Glu Glu Leu 
65                  70                  75                  80  


Glu Thr Phe Asn Ser Arg Trp Arg Glu Leu His Glu Glu Ala Val Arg 
                85                  90                  95      


Arg Gln Lys Leu Leu Glu Gln Ser 
            100                 


<210>  15
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  15

Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln Glu 
1               5                   10                  15      


Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala Asp Lys 
            20                  25                  30          


Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile Gln Ser Asp 
        35                  40                  45              


Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys Lys His Asn Gln 
    50                  55                  60                  


Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln Ile Asp Val Ala Gln 
65                  70                  75                  80  


Lys Lys Leu Gln Asp Val Ser Met Lys Phe Arg Leu 
                85                  90          


<210>  16
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu Ser Lys Met 
1               5                   10                  15      


Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu Glu Thr Lys Ser 
            20                  25                  30          


Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn His Cys Val Asn Leu 
        35                  40                  45              


Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu Val Glu Met Val Ile Lys 
    50                  55                  60                  


Thr Gly Arg Gln Ile Val Gln Lys Lys Gln Thr Glu Asn Pro Lys Glu 
65                  70                  75                  80  


Leu Asp Glu Arg Val Thr Ala Leu Lys Leu His Tyr Asn Glu Leu Gly 
                85                  90                  95      


Ala Lys Val Thr Glu Arg Lys Gln Gln Leu Glu Lys Cys 
            100                 105                 


<210>  17
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  17

Leu Lys Leu Ser Arg Lys Met Arg Lys Glu Met Asn Val Leu Thr Glu 
1               5                   10                  15      


Trp Leu Ala Ala Thr Asp Met Glu Leu Thr Lys Arg Ser Ala Val Glu 
            20                  25                  30          


Gly Met Pro Ser Asn Leu Asp Ser Glu Val Ala Trp Gly Lys Ala Thr 
        35                  40                  45              


Gln Lys Glu Ile Glu Lys Gln Lys Val His Leu Lys Ser Ile Thr Glu 
    50                  55                  60                  


Val Gly Glu Ala Leu Lys Thr Val Leu Gly Lys Lys Glu Thr Leu Val 
65                  70                  75                  80  


Glu Asp Lys Leu Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser 
                85                  90                  95      


Arg Ala Glu Glu Trp Leu Asn Leu Leu Leu Glu Tyr 
            100                 105             


<210>  18
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Lys His Met Glu Thr Phe Asp Gln Asn Val Asp His Ile Thr Lys 
1               5                   10                  15      


Trp Ile Ile Gln Ala Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys 
            20                  25                  30          


Pro Gln Gln Lys Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn 
        35                  40                  45              


Asp Ile Arg Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu 
    50                  55                  60                  


Met Ala Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile 
65                  70                  75                  80  


Ser Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr 
                85                  90                  95      


Gly Lys Ala Ser Ile Pro Leu Lys 
            100                 


<210>  19
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Leu Glu Gln Phe Asn Ser Asp Ile Gln Lys Leu Leu Glu Pro Leu 
1               5                   10                  15      


Glu Ala Glu Ile Gln Gln Gly Val Asn Leu Lys Glu Glu Asp Phe Asn 
            20                  25                  30          


Lys Asp Met Asn Glu Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln 
        35                  40                  45              


Arg Gly Asp Asn Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu 
    50                  55                  60                  


Glu Ile Lys Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu 
65                  70                  75                  80  


Lys Asp Leu Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile 
                85                  90                  


<210>  20
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser His Gln Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys 
1               5                   10                  15      


Cys Leu Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg 
            20                  25                  30          


Asp Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys 
        35                  40                  45              


Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu Ser Glu Asp 
    50                  55                  60                  


Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu Ser Lys Arg 
65                  70                  75                  80  


Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg Leu Asn Phe 
                85                  90                  95      


Ala Gln 
        


<210>  21
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  21

Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met 
1               5                   10                  15      


Pro Leu Glu Ile 
            20  


<210>  22
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln 
1               5                   10                  15      


Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala 
            20                  25                  30          


Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile 
        35                  40                  45              


Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser 
    50                  55                  60                  


Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 
65                  70                  75                  80  


Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn 
                85                  90                  95      


Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser 
            100                 105                 


<210>  23
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  23

Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 
1               5                   10                  15      


Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu 
            20                  25                  30          


Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp 
        35                  40                  45              


Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly 
    50                  55                  60                  


Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln 
65                  70                  75                  80  


Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln 
                85                  90                  95      


Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln 
            100                 105         


<210>  24
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  24

Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe Val Leu 
1               5                   10                  15      


Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu Glu Pro Gly 
            20                  25                  30          


Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val Lys Leu Leu Val 
        35                  40                  45              


Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys Gln Leu Asn Glu Thr 
    50                  55                  60                  


Gly Gly Pro Val Leu Val Ser Ala Pro Ile Ser Pro Glu Glu Gln Asp 
65                  70                  75                  80  


Lys Leu Glu Asn Lys Leu Lys Gln Thr Asn Leu Gln Trp Ile Lys Val 
                85                  90                  95      


Ser Arg Ala Leu Pro Glu Lys Gln Gly Glu Ile Glu Ala Gln Ile Lys 
            100                 105                 110         


Asp Leu Gly Gln Leu 
        115         


<210>  25
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Lys Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu 
1               5                   10                  15      


Trp Leu Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn 
            20                  25                  30          


Gln Glu Gly Pro Phe Asp Val Gln Glu Thr Glu Ile Ala Val Gln Ala 
        35                  40                  45              


Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His Leu Tyr 
    50                  55                  60                  


Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu Glu Asp Leu 
65                  70                  75                  80  


Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln Glu Leu Arg Ala 
                85                  90                  95      


Lys Gln Pro Asp Leu 
            100     


<210>  26
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  26

Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr 
1               5                   10                  15      


Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu 
            20                  25                  30          


Glu Met Pro Ser Ser Leu Met Leu Glu 
        35                  40      


<210>  27
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  27

Val Pro Ala Leu Ala Asp Phe Asn Arg Ala Trp Thr Glu Leu Thr Asp 
1               5                   10                  15      


Trp Leu Ser Leu Leu Asp Gln Val Ile Lys Ser Gln Arg Val Met Val 
            20                  25                  30          


Gly Asp Leu Glu Asp Ile Asn Glu Met Ile Ile Lys Gln Lys Ala Thr 
        35                  40                  45              


Met Gln Asp Leu Glu Gln Arg Arg Pro Gln Leu Glu Glu Leu Ile Thr 
    50                  55                  60                  


Ala Ala Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr 
65                  70                  75                  80  


Ile Ile Thr Asp Arg Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val 
                85                  90                  95      


Gln Glu His Leu Gln Asn Arg Arg Gln Gln Leu Asn Glu Met 
            100                 105                 110 


<210>  28
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  28

Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln 
1               5                   10                  15      


Val Leu Gly Gln Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro 
            20                  25                  30          


Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu 
        35                  40                  45              


Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp 
    50                  55                  60                  


Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys 
65                  70                  75                  80  


Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile His 
                85                  90                  95      


Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr 
            100                 105                 


<210>  29
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  29

His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala 
1               5                   10                  15      


Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr 
            20                  25                  30          


Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met 
        35                  40                  45              


Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val 
    50                  55                  60                  


Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu 
65                  70                  75                  80  


Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn 
                85                  90                  95      


Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His 
            100                 105                 110         


Leu Glu Ala Ser 
        115     


<210>  30
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val 
1               5                   10                  15      


Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly 
            20                  25                  30          


Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe 
        35                  40                  45              


Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu 
    50                  55                  60                  


Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 
65                  70                  75                  80  


Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn 
                85                  90                  95      


Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp 
            100                 105                 110         


Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu 
        115                 120                 125             


Thr 
    


<210>  31
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  31

Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu 
1               5                   10                  15      


Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly 
            20                  25                  30          


Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala 
        35                  40                  45              


Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn 
    50                  55                  60                  


Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr 
65                  70                  75                  80  


Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln 
                85                  90                  95      


Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu 
            100                 105             


<210>  32
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  32

Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser 
1               5                   10                  15      


Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr 
            20                  25                  30          


Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met 
        35                  40                  45              


Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser 
    50                  55                  60                  


Ala Tyr Arg Thr Ala Met Lys Leu 
65                  70          


<210>  33
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  33

Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala 
1               5                   10                  15      


Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro 
            20                  25                  30          


Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg 
        35                  40                  45              


Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp 
    50                  55                  60                  


Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly 
65                  70                  75                  80  


Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys 
                85                  90                  95      


Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser 
            100                 105                 110         


Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp 
        115                 120                 125             


Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly 
    130                 135                 140                 


Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn 
145                 150                 155                 160 


Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu 
                165                 170                 175     


Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala 
            180                 185                 190         


Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro 
        195                 200                 205             


Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile 
    210                 215                 220                 


Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met 
225                 230                 235                 240 


His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp 
                245                 250                 255     


Val Arg Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg 
            260                 265                 270         


Tyr Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val 
        275                 280                 285             


Leu Glu Gly Asp Asn Met Glu Thr 
    290                 295     


<210>  34
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  34

Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala Ser 
1               5                   10                  15      


Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu His Tyr 
            20                  25                  30          


Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn 
        35                  40                  45              


Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile 
    50                  55                  60                  


Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro 
65                  70                  75                  80  


Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly 
                85                  90                  95      


Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu 
            100                 105                 110         


Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys Gly Leu 
        115                 120                 125             


Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro Gln Ser 
    130                 135                 140                 


Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln His 
145                 150                 155                 160 


Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys 
                165                 170                 175     


Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro 
            180                 185                 190         


Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr 
        195                 200                 205             


Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val Val 
    210                 215                 220                 


Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu Ser Pro 
225                 230                 235                 240 


Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu Asn 
                245                 250                 255     


Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys Pro Met 
            260                 265                 270         


Arg Glu Asp Thr Met 
        275         


<210>  35
<211>  208
<212>  DNA
<213>  Homo sapiens

<400>  35
gggattccct cactttcccc ctacaggact cagatctggg aggcaattac cttcggagaa       60

aaacgaatag gaaaaactga agtgttactt tttttaaagc tgctgaagtt tgttggtttc      120

tcattgtttt taagcctact ggagcaataa agtttgaaga acttttacca ggtttttttt      180

atcgctgcct tgatatacac ttttcaaa                                         208


<210>  36
<211>  756
<212>  DNA
<213>  Homo sapiens

<400>  36
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaa                                756


<210>  37
<211>  255
<212>  DNA
<213>  Homo sapiens

<400>  37
atgttgccaa ggccacctaa agtgactaaa gaagaacatt ttcagttaca tcatcaaatg       60

cactattctc aacagatcac ggtcagtcta gcacagggat atgagagaac ttcttcccct      120

aagcctcgat tcaagagcta tgcctacaca caggctgctt atgtcaccac ctctgaccct      180

acacggagcc catttccttc acagcatttg gaagctcctg aagacaagtc atttggcagt      240

tcattgatgg agagt                                                       255


<210>  38
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  38
gaagtaaacc tggaccgtta tcaaacagct ttagaagaag tattatcgtg gcttctttct       60

gctgaggaca cattgcaagc acaaggagag atttctaatg atgtggaagt ggtgaaagac      120

cagtttcata ctcatgaggg gtacatgatg gatttgacag cccatcaggg ccgggttggt      180

aatattctac aattgggaag taagctgatt ggaacaggaa aattatcaga agatgaagaa      240

actgaagtac aagagcagat gaatctccta aattcaagat gggaatgcct cagggtagct      300

agcatggaaa aacaaagcaa tttacat                                          327


<210>  39
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  39
agagttttaa tggatctcca gaatcagaaa ctgaaagagt tgaatgactg gctaacaaaa       60

acagaagaaa gaacaaggaa aatggaggaa gagcctcttg gacctgatct tgaagaccta      120

aaacgccaag tacaacaaca taaggtgctt caagaagatc tagaacaaga acaagtcagg      180

gtcaattctc tcactcacat ggtggtggta gttgatgaat ctagtggaga tcacgcaact      240

gctgctttgg aagaacaact taaggtattg ggagatcgat gggcaaacat ctgtagatgg      300

acagaagacc gctgggttct tttacaagac atc                                   333


<210>  40
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  40
cttctcaaat ggcaacgtct tactgaagaa cagtgccttt ttagtgcatg gctttcagaa       60

aaagaagatg cagtgaacaa gattcacaca actggcttta aagatcaaaa tgaaatgtta      120

tcaagtcttc aaaaactggc cgttttaaaa gcggatctag aaaagaaaaa gcaatccatg      180

ggcaaactgt attcactcaa acaagatctt ctttcaacac tgaagaataa gtcagtgacc      240

cagaagacgg aagcatggct ggataacttt gcccggtgtt gggataattt agtccaaaaa      300

cttgaaaaga gtacagcaca gatttcacag gct                                   333


<210>  41
<211>  147
<212>  DNA
<213>  Homo sapiens

<400>  41
gtcaccacca ctcagccatc actaacacag acaactgtaa tggaaacagt aactacggtg       60

accacaaggg aacagatcct ggtaaagcat gctcaagagg aacttccacc accacctccc      120

caaaagaaga ggcagattac tgtggat                                          147


<210>  42
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  42
tctgaaatta ggaaaaggtt ggatgttgat ataactgaac ttcacagctg gattactcgc       60

tcagaagctg tgttgcagag tcctgaattt gcaatctttc ggaaggaagg caacttctca      120

gacttaaaag aaaaagtcaa tgccatagag cgagaaaaag ctgagaagtt cagaaaactg      180

caagatgcca gcagatcagc tcaggccctg gtggaacaga tggtgaatga gggtgttaat      240

gcagatagca tcaaacaagc ctcagaacaa ctgaacagcc ggtggatcga attctgccag      300

ttgctaagtg agagacttaa ctggctggag tat                                   333


<210>  43
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  43
cagaacaaca tcatcgcttt ctataatcag ctacaacaat tggagcagat gacaactact       60

gctgaaaact ggttgaaaat ccaacccacc accccatcag agccaacagc aattaaaagt      120

cagttaaaaa tttgtaagga tgaagtcaac cggctatcag gtcttcaacc tcaaattgaa      180

cgattaaaaa ttcaaagcat agccctgaaa gagaaaggac aaggacccat gttcctggat      240

gcagactttg tggcctttac aaatcatttt aagcaagtct tttctgatgt gcaggccaga      300

gagaaagagc tacagacaat ttttgac                                          327


<210>  44
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  44
actttgccac caatgcgcta tcaggagacc atgagtgcca tcaggacatg ggtccagcag       60

tcagaaacca aactctccat acctcaactt agtgtcaccg actatgaaat catggagcag      120

agactcgggg aattgcaggc tttacaaagt tctctgcaag agcaacaaag tggcctatac      180

tatctcagca ccactgtgaa agagatgtcg aagaaagcgc cctctgaaat tagccggaaa      240

tatcaatcag aatttgaaga aattgaggga cgctggaaga agctctcctc ccagctggtt      300

gagcattgtc aaaagctaga ggagcaa                                          327


<210>  45
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  45
atgaataaac tccgaaaaat tcagaatcac atacaaaccc tgaagaaatg gatggctgaa       60

gttgatgttt ttctgaagga ggaatggcct gcccttgggg attcagaaat tctaaaaaag      120

cagctgaaac agtgcagact tttagtcagt gatattcaga caattcagcc cagtctaaac      180

agtgtcaatg aaggtgggca gaagataaag aatgaagcag agccagagtt tgcttcgaga      240

cttgagacag aactcaaaga acttaacact cagtgggatc acatgtgcca acaggtctat      300

gccagaaagg aggccttgaa gggaggt                                          327


<210>  46
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  46
ttggagaaaa ctgtaagcct ccagaaagat ctatcagaga tgcacgaatg gatgacacaa       60

gctgaagaag agtatcttga gagagatttt gaatataaaa ctccagatga attacagaaa      120

gcagttgaag agatgaagag agctaaagaa gaggcccaac aaaaagaagc gaaagtgaaa      180

ctccttactg agtctgtaaa tagtgtcata gctcaagctc cacctgtagc acaagaggcc      240

ttaaaaaagg aacttgaaac tctaaccacc aactaccagt ggctctgcac taggctgaat      300

gggaaatgca agactttgga agaagtt                                          327


<210>  47
<211>  312
<212>  DNA
<213>  Homo sapiens

<400>  47
tgggcatgtt ggcatgagtt attgtcatac ttggagaaag caaacaagtg gctaaatgaa       60

gtagaattta aacttaaaac cactgaaaac attcctggcg gagctgagga aatctctgag      120

gtgctagatt cacttgaaaa tttgatgcga cattcagagg ataacccaaa tcagattcgc      180

atattggcac agaccctaac agatggcgga gtcatggatg agctaatcaa tgaggaactt      240

gagacattta attctcgttg gagggaacta catgaagagg ctgtaaggag gcaaaagttg      300

cttgaacaga gc                                                          312


<210>  48
<211>  276
<212>  DNA
<213>  Homo sapiens

<400>  48
atccagtctg cccaggagac tgaaaaatcc ttacacttaa tccaggagtc cctcacattc       60

attgacaagc agttggcagc ttatattgca gacaaggtgg acgcagctca aatgcctcag      120

gaagcccaga aaatccaatc tgatttgaca agtcatgaga tcagtttaga agaaatgaag      180

aaacataatc aggggaagga ggctgcccaa agagtcctgt ctcagattga tgttgcacag      240

aaaaaattac aagatgtctc catgaagttt cgatta                                276


<210>  49
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  49
ttccagaaac cagccaattt tgagctgcgt ctacaagaaa gtaagatgat tttagatgaa       60

gtgaagatgc acttgcctgc attggaaaca aagagtgtgg aacaggaagt agtacagtca      120

cagctaaatc attgtgtgaa cttgtataaa agtctgagtg aagtgaagtc tgaagtggaa      180

atggtgataa agactggacg tcagattgta cagaaaaagc agacggaaaa tcccaaagaa      240

cttgatgaaa gagtaacagc tttgaaattg cattataatg agctgggagc aaaggtaaca      300

gaaagaaagc aacagttgga gaaatgc                                          327


<210>  50
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  50
ttgaaattgt cccgtaagat gcgaaaggaa atgaatgtct tgacagaatg gctggcagct       60

acagatatgg aattgacaaa gagatcagca gttgaaggaa tgcctagtaa tttggattct      120

gaagttgcct ggggaaaggc tactcaaaaa gagattgaga aacagaaggt gcacctgaag      180

agtatcacag aggtaggaga ggccttgaaa acagttttgg gcaagaagga gacgttggtg      240

gaagataaac tcagtcttct gaatagtaac tggatagctg tcacctcccg agcagaagag      300

tggttaaatc ttttgttgga atac                                             324


<210>  51
<211>  312
<212>  DNA
<213>  Homo sapiens

<400>  51
cagaaacaca tggaaacttt tgaccagaat gtggaccaca tcacaaagtg gatcattcag       60

gctgacacac ttttggatga atcagagaaa aagaaacccc agcaaaaaga agacgtgctt      120

aagcgtttaa aggcagaact gaatgacata cgcccaaagg tggactctac acgtgaccaa      180

gcagcaaact tgatggcaaa ccgcggtgac cactgcagga aattagtaga gccccaaatc      240

tcagagctca accatcgatt tgcagccatt tcacacagaa ttaagactgg aaaggcctcc      300

attcctttga ag                                                          312


<210>  52
<211>  282
<212>  DNA
<213>  Homo sapiens

<400>  52
gaattggagc agtttaactc agatatacaa aaattgcttg aaccactgga ggctgaaatt       60

cagcaggggg tgaatctgaa agaggaagac ttcaataaag atatgaatga agacaatgag      120

ggtactgtaa aagaattgtt gcaaagagga gacaacttac aacaaagaat cacagatgag      180

agaaagagag aggaaataaa gataaaacag cagctgttac agacaaaaca taatgctctc      240

aaggatttga ggtctcaaag aagaaaaaag gctctagaaa tt                         282


<210>  53
<211>  294
<212>  DNA
<213>  Homo sapiens

<400>  53
tctcatcagt ggtatcagta caagaggcag gctgatgatc tcctgaaatg cttggatgac       60

attgaaaaaa aattagccag cctacctgag cccagagatg aaaggaaaat aaaggaaatt      120

gatcgggaat tgcagaagaa gaaagaggag ctgaatgcag tgcgtaggca agctgagggc      180

ttgtctgagg atggggccgc aatggcagtg gagccaactc agatccagct cagcaagcgc      240

tggcgggaaa ttgagagcaa atttgctcag tttcgaagac tcaactttgc acaa            294


<210>  54
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  54
attcacactg tccgtgaaga aacgatgatg gtgatgactg aagacatgcc tttggaaatt       60


<210>  55
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  55
tcttatgtgc cttctactta tttgactgaa atcactcatg tctcacaagc cctattagaa       60

gtggaacaac ttctcaatgc tcctgacctc tgtgctaagg actttgaaga tctctttaag      120

caagaggagt ctctgaagaa tataaaagat agtctacaac aaagctcagg tcggattgac      180

attattcata gcaagaagac agcagcattg caaagtgcaa cgcctgtgga aagggtgaag      240

ctacaggaag ctctctccca gcttgatttc caatgggaaa aagttaacaa aatgtacaag      300

gaccgacaag ggcgatttga cagatct                                          327


<210>  56
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  56
gttgagaaat ggcggcgttt tcattatgat ataaagatat ttaatcagtg gctaacagaa       60

gctgaacagt ttctcagaaa gacacaaatt cctgagaatt gggaacatgc taaatacaaa      120

tggtatctta aggaactcca ggatggcatt gggcagcggc aaactgttgt cagaacattg      180

aatgcaactg gggaagaaat aattcagcaa tcctcaaaaa cagatgccag tattctacag      240

gaaaaattgg gaagcctgaa tctgcggtgg caggaggtct gcaaacagct gtcagacaga      300

aaaaagaggc tagaagaaca a                                                321


<210>  57
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  57
aagaatatct tgtcagaatt tcaaagagat ttaaatgaat ttgttttatg gttggaggaa       60

gcagataaca ttgctagtat cccacttgaa cctggaaaag agcagcaact aaaagaaaag      120

cttgagcaag tcaagttact ggtggaagag ttgcccctgc gccagggaat tctcaaacaa      180

ttaaatgaaa ctggaggacc cgtgcttgta agtgctccca taagcccaga agagcaagat      240

aaacttgaaa ataagctcaa gcagacaaat ctccagtgga taaaggtttc cagagcttta      300

cctgagaaac aaggagaaat tgaagctcaa ataaaagacc ttgggcagct t               351


<210>  58
<211>  303
<212>  DNA
<213>  Homo sapiens

<400>  58
gaaaaaaagc ttgaagacct tgaagagcag ttaaatcatc tgctgctgtg gttatctcct       60

attaggaatc agttggaaat ttataaccaa ccaaaccaag aaggaccatt tgacgttcag      120

gaaactgaaa tagcagttca agctaaacaa ccggatgtgg aagagatttt gtctaaaggg      180

cagcatttgt acaaggaaaa accagccact cagccagtga agaggaagtt agaagatctg      240

agctctgagt ggaaggcggt aaaccgttta cttcaagagc tgagggcaaa gcagcctgac      300

cta                                                                    303


<210>  59
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  59
gctcctggac tgaccactat tggagcctct cctactcaga ctgttactct ggtgacacaa       60

cctgtggtta ctaaggaaac tgccatctcc aaactagaaa tgccatcttc cttgatgttg      120

gag                                                                    123


<210>  60
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  60
gtacctgctc tggcagattt caaccgggct tggacagaac ttaccgactg gctttctctg       60

cttgatcaag ttataaaatc acagagggtg atggtgggtg accttgagga tatcaacgag      120

atgatcatca agcagaaggc aacaatgcag gatttggaac agaggcgtcc ccagttggaa      180

gaactcatta ccgctgccca aaatttgaaa aacaagacca gcaatcaaga ggctagaaca      240

atcattacgg atcgaattga aagaattcag aatcagtggg atgaagtaca agaacacctt      300

cagaaccgga ggcaacagtt gaatgaaatg                                       330


<210>  61
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  61
ttaaaggatt caacacaatg gctggaagct aaggaagaag ctgagcaggt cttaggacag       60

gccagagcca agcttgagtc atggaaggag ggtccctata cagtagatgc aatccaaaag      120

aaaatcacag aaaccaagca gttggccaaa gacctccgcc agtggcagac aaatgtagat      180

gtggcaaatg acttggccct gaaacttctc cgggattatt ctgcagatga taccagaaaa      240

gtccacatga taacagagaa tatcaatgcc tcttggagaa gcattcataa aagggtgagt      300

gagcgagagg ctgctttgga agaaact                                          327


<210>  62
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  62
catagattac tgcaacagtt ccccctggac ctggaaaagt ttcttgcctg gcttacagaa       60

gctgaaacaa ctgccaatgt cctacaggat gctacccgta aggaaaggct cctagaagac      120

tccaagggag taaaagagct gatgaaacaa tggcaagacc tccaaggtga aattgaagct      180

cacacagatg tttatcacaa cctggatgaa aacagccaaa aaatcctgag atccctggaa      240

ggttccgatg atgcagtcct gttacaaaga cgtttggata acatgaactt caagtggagt      300

gaacttcgga aaaagtctct caacattagg tcccatttgg aagccagt                   348


<210>  63
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  63
tctgaccagt ggaagcgtct gcacctttct ctgcaggaac ttctggtgtg gctacagctg       60

aaagatgatg aattaagccg gcaggcacct attggaggcg actttccagc agttcagaag      120

cagaacgatg tacatagggc cttcaagagg gaattgaaaa ctaaagaacc tgtaatcatg      180

agtactcttg agactgtacg aatatttctg acagagcagc ctttggaagg actagagaaa      240

ctctaccagg agcccagaga gctgcctcct gaggagagag cccagaatgt cactcggctt      300

ctacgaaagc aggctgagga ggtcaatact gagtgggaaa aattgaacct gcactccgct      360

gactggcaga gaaaaataga tgagacc                                          387


<210>  64
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  64
cttgaaagac tccaggaact tcaagaggcc acggatgagc tggacctcaa gctgcgccaa       60

gctgaggtga tcaagggatc ctggcagccc gtgggcgatc tcctcattga ctctctccaa      120

gatcacctcg agaaagtcaa ggcacttcga ggagaaattg cgcctctgaa agagaacgtg      180

agccacgtca atgaccttgc tcgccagctt accactttgg gcattcagct ctcaccgtat      240

aacctcagca ctctggaaga cctgaacacc agatggaagc ttctgcaggt ggccgtcgag      300

gaccgagtca ggcagctgca tgaa                                             324


<210>  65
<211>  216
<212>  DNA
<213>  Homo sapiens

<400>  65
gcccacaggg actttggtcc agcatctcag cactttcttt ccacgtctgt ccagggtccc       60

tgggagagag ccatctcgcc aaacaaagtg ccctactata tcaaccacga gactcaaaca      120

acttgctggg accatcccaa aatgacagag ctctaccagt ctttagctga cctgaataat      180

gtcagattct cagcttatag gactgccatg aaactc                                216


<210>  66
<211>  888
<212>  DNA
<213>  Homo sapiens

<400>  66
cgaagactgc agaaggccct ttgcttggat ctcttgagcc tgtcagctgc atgtgatgcc       60

ttggaccagc acaacctcaa gcaaaatgac cagcccatgg atatcctgca gattattaat      120

tgtttgacca ctatttatga ccgcctggag caagagcaca acaatttggt caacgtccct      180

ctctgcgtgg atatgtgtct gaactggctg ctgaatgttt atgatacggg acgaacaggg      240

aggatccgtg tcctgtcttt taaaactggc atcatttccc tgtgtaaagc acatttggaa      300

gacaagtaca gatacctttt caagcaagtg gcaagttcaa caggattttg tgaccagcgc      360

aggctgggcc tccttctgca tgattctatc caaattccaa gacagttggg tgaagttgca      420

tcctttgggg gcagtaacat tgagccaagt gtccggagct gcttccaatt tgctaataat      480

aagccagaga tcgaagcggc cctcttccta gactggatga gactggaacc ccagtccatg      540

gtgtggctgc ccgtcctgca cagagtggct gctgcagaaa ctgccaagca tcaggccaaa      600

tgtaacatct gcaaagagtg tccaatcatt ggattcaggt acaggagtct aaagcacttt      660

aattatgaca tctgccaaag ctgctttttt tctggtcgag ttgcaaaagg ccataaaatg      720

cactatccca tggtggaata ttgcactccg actacatcag gagaagatgt tcgagacttt      780

gccaaggtac taaaaaacaa atttcgaacc aaaaggtatt ttgcgaagca tccccgaatg      840

ggctacctgc cagtgcagac tgtcttagag ggggacaaca tggaaact                   888


<210>  67
<211>  834
<212>  DNA
<213>  Homo sapiens

<400>  67
cccgttactc tgatcaactt ctggccagta gattctgcgc ctgcctcgtc ccctcagctt       60

tcacacgatg atactcattc acgcattgaa cattatgcta gcaggctagc agaaatggaa      120

aacagcaatg gatcttatct aaatgatagc atctctccta atgagagcat agatgatgaa      180

catttgttaa tccagcatta ctgccaaagt ttgaaccagg actcccccct gagccagcct      240

cgtagtcctg cccagatctt gatttcctta gagagtgagg aaagagggga gctagagaga      300

atcctagcag atcttgagga agaaaacagg aatctgcaag cagaatatga ccgtctaaag      360

cagcagcacg aacataaagg cctgtcccca ctgccgtccc ctcctgaaat gatgcccacc      420

tctccccaga gtccccggga tgctgagctc attgctgagg ccaagctact gcgtcaacac      480

aaaggccgcc tggaagccag gatgcaaatc ctggaagacc acaataaaca gctggagtca      540

cagttacaca ggctaaggca gctgctggag caaccccagg cagaggccaa agtgaatggc      600

acaacggtgt cctctccttc tacctctcta cagaggtccg acagcagtca gcctatgctg      660

ctccgagtgg ttggcagtca aacttcggac tccatgggtg aggaagatct tctcagtcct      720

ccccaggaca caagcacagg gttagaggag gtgatggagc aactcaacaa ctccttccct      780

agttcaagag gaagaaatac ccctggaaag ccaatgagag aggacacaat gtag            834


<210>  68
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu 
                245                 250         


<210>  69
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Leu Pro Arg Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu 
1               5                   10                  15      


His His Gln Met His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln 
            20                  25                  30          


Gly Tyr Glu Arg Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala 
        35                  40                  45              


Tyr Thr Gln Ala Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro 
    50                  55                  60                  


Phe Pro Ser Gln His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser 
65                  70                  75                  80  


Ser Leu Met Glu Ser 
                85  


<210>  70
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  70

Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu Ser 
1               5                   10                  15      


Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile Ser 
            20                  25                  30          


Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly Tyr 
        35                  40                  45              


Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu Gln 
    50                  55                  60                  


Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu Glu 
65                  70                  75                  80  


Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu Cys 
                85                  90                  95      


Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His 
            100                 105                 


<210>  71
<211>  2
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  RV-Linker

<400>  71

Arg Val 
1       


<210>  72
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  72

Leu Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala 
1               5                   10                  15      


Trp Leu Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly 
            20                  25                  30          


Phe Lys Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val 
        35                  40                  45              


Leu Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr 
    50                  55                  60                  


Ser Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr 
65                  70                  75                  80  


Gln Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn 
                85                  90                  95      


Leu Val Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala 
            100                 105                 110     


<210>  73
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  73

Val Thr Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr 
1               5                   10                  15      


Val Thr Thr Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln 
            20                  25                  30          


Glu Glu Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val 
        35                  40                  45              


Asp 
    


<210>  74
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  SEAQ linker

<400>  74

Ser Glu Ala Gln 
1               


<210>  75
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  75

Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met 
1               5                   10                  15      


Pro Leu Glu Ile 
            20  


<210>  76
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  76

Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln 
1               5                   10                  15      


Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala 
            20                  25                  30          


Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile 
        35                  40                  45              


Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser 
    50                  55                  60                  


Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 
65                  70                  75                  80  


Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn 
                85                  90                  95      


Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser 
            100                 105                 


<210>  77
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  77

Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 
1               5                   10                  15      


Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu 
            20                  25                  30          


Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp 
        35                  40                  45              


Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly 
    50                  55                  60                  


Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln 
65                  70                  75                  80  


Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln 
                85                  90                  95      


Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln 
            100                 105         


<210>  78
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  78

Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu 
1               5                   10                  15      


Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly 
            20                  25                  30          


Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala 
        35                  40                  45              


Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn 
    50                  55                  60                  


Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr 
65                  70                  75                  80  


Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln 
                85                  90                  95      


Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu 
            100                 105             


<210>  79
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser 
1               5                   10                  15      


Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr 
            20                  25                  30          


Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met 
        35                  40                  45              


Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser 
    50                  55                  60                  


Ala Tyr Arg Thr Ala Met Lys Leu 
65                  70          


<210>  80
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  80

Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala 
1               5                   10                  15      


Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro 
            20                  25                  30          


Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg 
        35                  40                  45              


Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp 
    50                  55                  60                  


Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly 
65                  70                  75                  80  


Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys 
                85                  90                  95      


Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser 
            100                 105                 110         


Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp 
        115                 120                 125             


Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly 
    130                 135                 140                 


Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn 
145                 150                 155                 160 


Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu 
                165                 170                 175     


Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala 
            180                 185                 190         


Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro 
        195                 200                 205             


Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile 
    210                 215                 220                 


Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met 
225                 230                 235                 240 


His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp 
                245                 250                 255     


Val Arg Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg 
            260                 265                 270         


Tyr Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val 
        275                 280                 285             


Leu Glu Gly Asp Asn Met Glu Thr Asp Thr Met 
    290                 295                 


<210>  81
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu 
                245                 250         


<210>  82
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Leu Pro Arg Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu 
1               5                   10                  15      


His His Gln Met His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln 
            20                  25                  30          


Gly Tyr Glu Arg Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala 
        35                  40                  45              


Tyr Thr Gln Ala Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro 
    50                  55                  60                  


Phe Pro Ser Gln His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser 
65                  70                  75                  80  


Ser Leu Met Glu Ser 
                85  


<210>  83
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  83

Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu Ser 
1               5                   10                  15      


Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile Ser 
            20                  25                  30          


Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly Tyr 
        35                  40                  45              


Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu Gln 
    50                  55                  60                  


Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu Glu 
65                  70                  75                  80  


Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu Cys 
                85                  90                  95      


Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His 
            100                 105                 


<210>  84
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  84

Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met 
1               5                   10                  15      


Pro Leu Glu Ile 
            20  


<210>  85
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  85

Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln 
1               5                   10                  15      


Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala 
            20                  25                  30          


Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile 
        35                  40                  45              


Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser 
    50                  55                  60                  


Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 
65                  70                  75                  80  


Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn 
                85                  90                  95      


Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser 
            100                 105                 


<210>  86
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  86

Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln 
1               5                   10                  15      


Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu 
            20                  25                  30          


Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp 
        35                  40                  45              


Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly 
    50                  55                  60                  


Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln 
65                  70                  75                  80  


Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln 
                85                  90                  95      


Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln 
            100                 105         


<210>  87
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  87

Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr 
1               5                   10                  15      


Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu 
            20                  25                  30          


Glu Met Pro Ser Ser Leu Met Leu Glu 
        35                  40      


<210>  88
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  88

Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val 
1               5                   10                  15      


Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly 
            20                  25                  30          


Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe 
        35                  40                  45              


Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu 
    50                  55                  60                  


Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 
65                  70                  75                  80  


Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn 
                85                  90                  95      


Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp 
            100                 105                 110         


Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu 
        115                 120                 125             


Thr 
    


<210>  89
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  89

Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu 
1               5                   10                  15      


Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly 
            20                  25                  30          


Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala 
        35                  40                  45              


Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn 
    50                  55                  60                  


Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr 
65                  70                  75                  80  


Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln 
                85                  90                  95      


Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu 
            100                 105             


<210>  90
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  90

Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser 
1               5                   10                  15      


Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr 
            20                  25                  30          


Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met 
        35                  40                  45              


Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser 
    50                  55                  60                  


Ala Tyr Arg Thr Ala Met Lys Leu 
65                  70          


<210>  91
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  91

Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala 
1               5                   10                  15      


Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro 
            20                  25                  30          


Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg 
        35                  40                  45              


Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp 
    50                  55                  60                  


Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly 
65                  70                  75                  80  


Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys 
                85                  90                  95      


Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser 
            100                 105                 110         


Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp 
        115                 120                 125             


Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly 
    130                 135                 140                 


Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn 
145                 150                 155                 160 


Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu 
                165                 170                 175     


Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala 
            180                 185                 190         


Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro 
        195                 200                 205             


Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile 
    210                 215                 220                 


Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met 
225                 230                 235                 240 


His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp 
                245                 250                 255     


Val Arg Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg 
            260                 265                 270         


Tyr Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val 
        275                 280                 285             


Leu Glu Gly Asp Asn Met Glu Thr Pro Ala Gln Ile Leu Ile Ser Leu 
    290                 295                 300                 


Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu 
305                 310                 315                 320 


Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln 
                325                 330                 335     


His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Asp Thr Met 
            340                 345                 350         


<210>  92
<211>  322
<212>  DNA
<213>  Homo sapiens

<400>  92
ccgccttcgg caccattcct cacgacaccc aaatatggca cgggtgagga atggtgggga       60

gttattttag agcggtgagg aaggtgggca ggcagcaggt gttggcgctc taaaaataac      120

tcccgggagt tattttagag cggaggaatg gtggacaccc aaataggcga cggttcctca      180

cccgtcgcca tatttgggtg tccgccctcg gccggggccg cattcctggg gccgggcggt      240

gctcccgccc gcctcgataa aaggctccgg ggccggcggc ggcccacgag ctacccggag      300

gagcgggagg ctctagacca cc                                               322


<210>  93
<211>  756
<212>  DNA
<213>  Homo sapiens

<400>  93
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaa                                756


<210>  94
<211>  255
<212>  DNA
<213>  Homo sapiens

<400>  94
atgctgccca gaccccccaa agtgaccaaa gaggaacact tccagctgca ccaccagatg       60

cactacagcc agcagatcac cgtgtccctg gcccagggct acgagagaac cagcagcccc      120

aagccccggt tcaagagcta cgcctatacc caggccgcct acgtgaccac cagcgaccct      180

accagaagcc cattccccag ccagcatctg gaagcccccg aggacaagag cttcggcagc      240

agcctgatgg aaagc                                                       255


<210>  95
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  95
gaagtgaacc tggacagata ccagaccgcc ctggaagagg tgctgagctg gctgctgagc       60

gccgaggata cactgcaggc tcagggcgag atcagcaacg acgtggaagt cgtgaaggac      120

cagttccaca cccacgaggg ctacatgatg gacctgacag cccaccaggg cagagtgggc      180

aacatcctgc agctgggctc caagctgatc ggcaccggca agctgagcga ggacgaagag      240

acagaggtgc aggaacagat gaacctgctg aacagcagat gggagtgcct gcgggtggcc      300

agcatggaaa agcagagcaa cctgcat                                          327


<210>  96
<211>  6
<212>  DNA
<213>  Homo sapiens

<400>  96
agggtc                                                                   6


<210>  97
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  97
ctgctgaagt ggcagcggct gaccgaggaa cagtgcctgt ttagcgcctg gctgtccgag       60

aaagaggacg ccgtgaacaa gatccacacc accggcttca aggaccagaa cgagatgctg      120

agcagcctgc agaaactggc cgtgctgaag gccgacctgg aaaagaaaaa gcagtccatg      180

ggcaagctgt actccctgaa gcaggacctg ctgtccaccc tgaagaacaa gagcgtgacc      240

cagaaaaccg aggcctggct ggacaacttc gcccggtgct gggacaacct ggtgcagaag      300

ctggaaaagt ccaccgccca gatctcccag gcc                                   333


<210>  98
<211>  147
<212>  DNA
<213>  Homo sapiens

<400>  98
gtgaccacaa cacagcccag cctgacccag accaccgtga tggaaaccgt gacaacagtg       60

accacccggg aacagatcct cgtgaagcac gcccaggaag aactgccccc tccacccccc      120

cagaagaaac ggcagatcac agtggac                                          147


<210>  99
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  99
agtgaagctc ag                                                           12


<210>  100
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  100
atccacaccg tgcgggaaga gacaatgatg gtcatgacag aggacatgcc cctggaaatc       60


<210>  101
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  101
agctacgtgc ccagcaccta cctgaccgag atcacccatg tgtcccaggc cctgctggaa       60

gtggaacagc tgctgaacgc ccccgacctg tgcgccaagg atttcgagga cctgttcaag      120

caggaagaga gcctgaagaa tatcaaggat agcctgcagc agagcagcgg ccggatcgac      180

atcatccaca gcaagaaaac agccgccctg cagagcgcca cccccgtgga aagagtgaaa      240

ctgcaggaag ccctgtccca gctggacttc cagtgggaga aagtgaacaa aatgtacaag      300

gaccggcagg gcagattcga ccgcagc                                          327


<210>  102
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  102
gtggaaaagt ggcggcggtt ccactacgac atcaagatct tcaaccagtg gctgacagag       60

gccgagcagt tcctgagaaa gacccagatc cccgagaact gggagcacgc caagtacaag      120

tggtatctga aagagctgca ggacggcatc ggccagagac agacagtcgt gcggaccctg      180

aatgccaccg gcgaggaaat catccagcag tccagcaaga ccgacgccag cattctgcag      240

gaaaagctgg gcagcctgaa cctgcggtgg caggaagtgt gcaagcagct gtccgaccgg      300

aagaagcggc tggaagaaca g                                                321


<210>  103
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  103
ctggaacggc tgcaggaact gcaggaggcc accgacgagc tggacctgaa actgagacag       60

gccgaagtga tcaagggcag ctggcagcca gtgggcgacc tgctgatcga ctccctgcag      120

gaccatctgg aaaaagtgaa ggccctgaga ggcgagatcg cccccctgaa agaaaacgtg      180

tcccacgtga acgacctggc ccggcagctg acaacactgg gcattcagct gagcccctac      240

aacctgagca cactggaaga tctgaacacc cggtggaagc tgctgcaggt ggccgtggaa      300

gatagagtgc ggcagctgca cgag                                             324


<210>  104
<211>  215
<212>  DNA
<213>  Homo sapiens

<400>  104
gcccacagag attttggccc tgcctcccag cacttcctga gcaccagtgt gcagggccct       60

tgggagagag ccatctcccc taacaaggtg ccctactaca tcaaccacga gacacagacc      120

acctgttggg accaccccaa gatgaccgag ctgtaccaga gcctggctga cctgaacaac      180

gtgcggttca ggcctaccgg accgccatga agctg                                 215


<210>  105
<211>  1068
<212>  DNA
<213>  Homo sapiens

<400>  105
cggagactgc agaaagctct gtgcctggat ctgctgtccc tgtccgccgc ctgtgatgcc       60

ctggaccagc acaatctgaa gcagaacgac cagcccatgg atatcctgca gatcatcaac      120

tgcctgacca ccatctacga ccggctggaa caggaacaca acaatctcgt gaacgtgccc      180

ctgtgcgtgg acatgtgcct gaattggctg ctgaatgtgt acgacaccgg ccggacaggc      240

cggatcagag tgctgtcctt caagaccggc atcatcagcc tgtgcaaagc ccacctggaa      300

gataagtacc ggtatctgtt caaacaggtg gcctctagca ccggcttttg cgaccagaga      360

aggctgggcc tgctgctgca cgacagcatc cagatcccta gacagctggg cgaagtggcc      420

agctttggcg gcagcaacat cgagcctagc gtgcggagct gcttccagtt cgccaacaac      480

aagcccgaga tcgaggccgc cctgttcctg gactggatga gactggaacc ccagagcatg      540

gtgtggctgc ccgtgctgca tagagtggcc gctgccgaga cagccaagca ccaggccaag      600

tgcaacatct gcaaagagtg ccccatcatc ggcttccggt acagaagcct gaagcacttc      660

aactacgata tctgccagag ctgtttcttc agcggcaggg tggccaaggg ccacaaaatg      720

cactacccca tggtggaata ctgcaccccc accacaagcg gcgaggatgt gcgggatttc      780

gccaaggtgc tgaaaaacaa gttccggacc aagcggtact tcgccaaaca cccccggatg      840

ggctacctgc ctgtgcagac agtgctggaa ggcgacaaca tggaaaccga caccatgtga      900

tgatgatttg ggcagagcga tggagtcctt agtatcagtc atgacagatg aagaaggagc      960

agaataaatg ttttacaact cctgattccc gcatgcggcc agcttatcga taccgtcgaa     1020

ataaaagatc cttattttca ttggatctgt gtgttggttt tttgtgtg                  1068


<210>  106
<211>  334
<212>  DNA
<213>  Homo sapiens

<400>  106
cctgcggccg ccttcggcac cattcctcac gacacccaaa tatggcgacg ggtgaggaat       60

ggtggggagt tatttttaga gcggtgagga aggtgggcag gcagcaggtg ttggcgctct      120

aaaaataact cccgggagtt atttttagag cggaggaatg gtggacaccc aaatatggcg      180

acggttcctc acccgtcgcc atatttgggt gtccgccctc ggccggggcc gcattcctgg      240

gggccgggcg gtgctcccgc ccgcctcgat aaaaggctcc ggggccggcg gcggcccacg      300

agctacccgg aggagcggga ggctctagac cacc                                  334


<210>  107
<211>  756
<212>  DNA
<213>  Homo sapiens

<400>  107
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaa                                756


<210>  108
<211>  255
<212>  DNA
<213>  Homo sapiens

<400>  108
atgctgccca gaccccccaa agtgaccaaa gaggaacact tccagctgca ccaccagatg       60

cactacagcc agcagatcac cgtgtccctg gctcagggct acgagcggac cagcagcccc      120

aagccccggt tcaagagcta cgcctacacc caggccgcct acgtgaccac cagcgacccc      180

accagaagcc cattccccag ccagcatctg gaagcccccg aggacaagag cttcggcagc      240

agcctgatgg aaagc                                                       255


<210>  109
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  109
gaagtgaacc tggacagata ccagaccgcc ctggaagagg tgctgtcctg gctgctgagc       60

gccgaggata cactgcaggc ccagggcgag atcagcaacg acgtggaagt ggtgaaagac      120

cagttccaca cccacgaggg ctacatgatg gacctgaccg cccaccaggg cagagtgggc      180

aacatcctgc agctgggcag caagctgatc ggcaccggca agctgagcga ggacgaagag      240

acagaggtgc aggaacagat gaacctgctg aacagcagat gggagtgcct gcgggtggcc      300

agcatggaaa agcagagcaa cctgcac                                          327


<210>  110
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  110
atccacaccg tgcgggaaga gacaatgatg gtgatgaccg aggacatgcc cctggaaatc       60


<210>  111
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  111
agctacgtgc ccagcaccta cctgaccgag atcacccacg tgtcccaggc tctgctggaa       60

gtggaacagc tgctgaacgc ccccgacctg tgcgccaagg acttcgagga tctgttcaag      120

caggaagaga gcctgaagaa tatcaaggac tccctgcagc agtccagcgg ccggatcgac      180

atcatccaca gcaagaaaac agccgccctg cagtccgcca cccccgtgga aagagtgaag      240

ctgcaggaag ccctgagcca gctggacttc cagtgggaga aagtgaacaa gatgtacaag      300

gaccggcagg gcagattcga ccgcagc                                          327


<210>  112
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  112
gtggaaaagt ggcggcggtt ccactacgac atcaagatct tcaaccagtg gctgaccgag       60

gccgagcagt tcctgagaaa gacccagatc cccgagaact gggagcacgc caagtacaag      120

tggtatctga aagaactgca ggatggcatc ggccagcggc agaccgtggt gcgcacactg      180

aatgccaccg gcgaggaaat catccagcag agcagcaaga ccgacgccag catcctgcag      240

gaaaagctgg gctccctgaa cctgcggtgg caggaagtgt gcaagcagct gagcgaccgg      300

aagaagaggc tggaagaaca g                                                321


<210>  113
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  113
gcccctggcc tgaccaccat cggcgccagc cctacccaga ccgtgaccct ggtgacacag       60

cccgtggtga caaaagagac agccatctcc aagctggaaa tgcccagctc cctgatgctg      120

gaa                                                                    123


<210>  114
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  114
tctgaccagt ggaagcgtct gcacctttct ctgcaggaac ttctggtgtg gctacagctg       60

aaagatgatg aattaagccg gcaggcacct attggaggcg actttccagc agttcagaag      120

cagaacgatg tacatagggc cttcaagagg gaattgaaaa ctaaagaacc tgtaatcatg      180

agtactcttg agactgtacg aatatttctg acagagcagc ctttggaagg actagagaaa      240

ctctaccagg agcccagaga gctgcctcct gaggagagag cccagaatgt cactcggctt      300

ctacgaaagc aggctgagga ggtcaatact gagtgggaaa aattgaacct gcactccgct      360

gactggcaga gaaaaataga tgagacc                                          387


<210>  115
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  115
ctggaaaggc tgcaggaact gcaggaggcc accgacgagc tggacctgaa gctgcggcag       60

gccgaagtga tcaagggcag ctggcagccc gtgggcgacc tgctgatcga cagcctgcag      120

gaccacctgg aaaaagtgaa ggccctgaga ggcgagatcg cccccctgaa agaaaacgtg      180

tcccacgtga acgacctggc ccggcagctg accaccctgg gcatccagct gagcccctac      240

aacctgagca ccctggaaga tctgaacacc cggtggaagc tgctgcaggt ggccgtggaa      300

gatagagtgc ggcagctgca cgag                                             324


<210>  116
<211>  216
<212>  DNA
<213>  Homo sapiens

<400>  116
gcccacagag actttggccc tgccagccag cacttcctga gcacctctgt gcagggaccc       60

tgggagagag ccatcagccc caacaaggtg ccctactaca tcaaccacga gacacagacc      120

acctgttggg accaccccaa gatgaccgag ctgtaccaga gcctggccga cctgaacaat      180

gtgcggttca gcgcctaccg gaccgccatg aagctg                                216


<210>  117
<211>  1059
<212>  DNA
<213>  Homo sapiens

<400>  117
aggcggctgc agaaagctct gtgcctggat ctgctgagcc tgagcgccgc ctgcgacgcc       60

ctggaccagc acaacctgaa gcagaacgac cagcccatgg atatcctgca gatcatcaac      120

tgcctgacca caatctacga caggctggaa caggaacaca acaatctggt caacgtgccc      180

ctgtgcgtgg acatgtgcct gaattggctg ctgaatgtgt acgacaccgg ccggaccggc      240

agaatccggg tgctgagctt caagaccggc atcatcagcc tgtgcaaggc ccacctggaa      300

gataagtacc gctacctgtt caaacaggtg gccagctcca ccggcttttg cgaccagcgg      360

agactgggcc tgctgctgca cgacagcatc cagatcccca gacagctggg cgaggtggcc      420

tccttcggcg gcagcaacat tgagcccagc gtgcggagct gcttccagtt cgccaacaac      480

aagcccgaga tcgaggccgc cctgttcctg gactggatga gactggaacc ccagagcatg      540

gtgtggctgc ccgtgctgca tcgggtggcc gctgccgaga cagccaagca ccaggccaag      600

tgcaacatct gcaaagagtg ccccatcatc ggcttccggt acagaagcct gaagcacttc      660

aactacgata tctgccagag ctgcttcttc agcggcagag tggccaaggg ccacaaaatg      720

cactacccca tggtggaata ctgcaccccc accaccagcg gcgaggatgt gcgggacttc      780

gccaaggtgc tgaaaaacaa gttccggacc aagcggtact ttgccaagca cccccggatg      840

ggctacctgc ccgtgcagac agtgctggaa ggcgacaaca tggaaacccc tgcccagatc      900

ctgatcagcc tggaaagcga ggaacggggc gagctggaac ggatcctggc cgatctggaa      960

gaggaaaacc ggaacctgca ggccgagtac gaccggctga agcagcagca cgagcacaag     1020

ggcctgagcc ccctgcctag cccccctgac accatgtga                            1059


<210>  118
<211>  1327
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala 
    450                 455                 460                 


Trp Leu Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly 
465                 470                 475                 480 


Phe Lys Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val 
                485                 490                 495     


Leu Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr 
            500                 505                 510         


Ser Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr 
        515                 520                 525             


Gln Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn 
    530                 535                 540                 


Leu Val Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val 
545                 550                 555                 560 


Thr Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val 
                565                 570                 575     


Thr Thr Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu 
            580                 585                 590         


Glu Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp 
        595                 600                 605             


Ser Glu Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val Met 
    610                 615                 620                 


Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu 
625                 630                 635                 640 


Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu 
                645                 650                 655     


Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys 
            660                 665                 670         


Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser 
        675                 680                 685             


Gly Arg Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser 
    690                 695                 700                 


Ala Thr Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu 
705                 710                 715                 720 


Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly 
                725                 730                 735     


Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile 
            740                 745                 750         


Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys 
        755                 760                 765             


Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu 
    770                 775                 780                 


Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr 
785                 790                 795                 800 


Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp 
                805                 810                 815     


Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln 
            820                 825                 830         


Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln 
        835                 840                 845             


Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu 
    850                 855                 860                 


Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly 
865                 870                 875                 880 


Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala 
                885                 890                 895     


Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn 
            900                 905                 910         


Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr 
        915                 920                 925             


Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln 
    930                 935                 940                 


Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp 
945                 950                 955                 960 


Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro 
                965                 970                 975     


Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His 
            980                 985                 990         


Glu Thr Gln Thr Thr Cys Trp Asp  His Pro Lys Met Thr  Glu Leu Tyr 
        995                 1000                 1005             


Gln Ser  Leu Ala Asp Leu Asn  Asn Val Arg Phe Ser  Ala Tyr Arg 
    1010                 1015                 1020             


Thr Ala  Met Lys Leu Arg Arg  Leu Gln Lys Ala Leu  Cys Leu Asp 
    1025                 1030                 1035             


Leu Leu  Ser Leu Ser Ala Ala  Cys Asp Ala Leu Asp  Gln His Asn 
    1040                 1045                 1050             


Leu Lys  Gln Asn Asp Gln Pro  Met Asp Ile Leu Gln  Ile Ile Asn 
    1055                 1060                 1065             


Cys Leu  Thr Thr Ile Tyr Asp  Arg Leu Glu Gln Glu  His Asn Asn 
    1070                 1075                 1080             


Leu Val  Asn Val Pro Leu Cys  Val Asp Met Cys Leu  Asn Trp Leu 
    1085                 1090                 1095             


Leu Asn  Val Tyr Asp Thr Gly  Arg Thr Gly Arg Ile  Arg Val Leu 
    1100                 1105                 1110             


Ser Phe  Lys Thr Gly Ile Ile  Ser Leu Cys Lys Ala  His Leu Glu 
    1115                 1120                 1125             


Asp Lys  Tyr Arg Tyr Leu Phe  Lys Gln Val Ala Ser  Ser Thr Gly 
    1130                 1135                 1140             


Phe Cys  Asp Gln Arg Arg Leu  Gly Leu Leu Leu His  Asp Ser Ile 
    1145                 1150                 1155             


Gln Ile  Pro Arg Gln Leu Gly  Glu Val Ala Ser Phe  Gly Gly Ser 
    1160                 1165                 1170             


Asn Ile  Glu Pro Ser Val Arg  Ser Cys Phe Gln Phe  Ala Asn Asn 
    1175                 1180                 1185             


Lys Pro  Glu Ile Glu Ala Ala  Leu Phe Leu Asp Trp  Met Arg Leu 
    1190                 1195                 1200             


Glu Pro  Gln Ser Met Val Trp  Leu Pro Val Leu His  Arg Val Ala 
    1205                 1210                 1215             


Ala Ala  Glu Thr Ala Lys His  Gln Ala Lys Cys Asn  Ile Cys Lys 
    1220                 1225                 1230             


Glu Cys  Pro Ile Ile Gly Phe  Arg Tyr Arg Ser Leu  Lys His Phe 
    1235                 1240                 1245             


Asn Tyr  Asp Ile Cys Gln Ser  Cys Phe Phe Ser Gly  Arg Val Ala 
    1250                 1255                 1260             


Lys Gly  His Lys Met His Tyr  Pro Met Val Glu Tyr  Cys Thr Pro 
    1265                 1270                 1275             


Thr Thr  Ser Gly Glu Asp Val  Arg Asp Phe Ala Lys  Val Leu Lys 
    1280                 1285                 1290             


Asn Lys  Phe Arg Thr Lys Arg  Tyr Phe Ala Lys His  Pro Arg Met 
    1295                 1300                 1305             


Gly Tyr  Leu Pro Val Gln Thr  Val Leu Glu Gly Asp  Asn Met Glu 
    1310                 1315                 1320             


Thr Asp  Thr Met 
    1325         


<210>  119
<211>  1321
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Leu Leu 
        435                 440                 445             


Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu 
    450                 455                 460                 


Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys 
465                 470                 475                 480 


Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys 
                485                 490                 495     


Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu 
            500                 505                 510         


Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys 
        515                 520                 525             


Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val 
    530                 535                 540                 


Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr 
545                 550                 555                 560 


Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr 
                565                 570                 575     


Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu 
            580                 585                 590         


Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ile His 
        595                 600                 605             


Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu 
    610                 615                 620                 


Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val 
625                 630                 635                 640 


Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu 
                645                 650                 655     


Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys 
            660                 665                 670         


Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile 
        675                 680                 685             


His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg 
    690                 695                 700                 


Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys 
705                 710                 715                 720 


Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 
                725                 730                 735     


Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp 
            740                 745                 750         


Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn 
        755                 760                 765             


Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly 
    770                 775                 780                 


Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu 
785                 790                 795                 800 


Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu 
                805                 810                 815     


Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu 
            820                 825                 830         


Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Leu Glu Arg Leu Gln Glu 
        835                 840                 845             


Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu 
    850                 855                 860                 


Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser 
865                 870                 875                 880 


Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala 
                885                 890                 895     


Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu 
            900                 905                 910         


Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 
        915                 920                 925             


Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg 
    930                 935                 940                 


Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln 
945                 950                 955                 960 


His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser 
                965                 970                 975     


Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys 
            980                 985                 990         


Trp Asp His Pro Lys Met Thr Glu  Leu Tyr Gln Ser Leu  Ala Asp Leu 
        995                 1000                 1005             


Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr Ala Met  Lys Leu Arg 
    1010                 1015                 1020             


Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu Leu Ser  Leu Ser Ala 
    1025                 1030                 1035             


Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu Lys Gln  Asn Asp Gln 
    1040                 1045                 1050             


Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys Leu Thr  Thr Ile Tyr 
    1055                 1060                 1065             


Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu Val Asn  Val Pro Leu 
    1070                 1075                 1080             


Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu Asn Val  Tyr Asp Thr 
    1085                 1090                 1095             


Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser Phe Lys  Thr Gly Ile 
    1100                 1105                 1110             


Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp Lys Tyr  Arg Tyr Leu 
    1115                 1120                 1125             


Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe Cys Asp  Gln Arg Arg 
    1130                 1135                 1140             


Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln Ile Pro  Arg Gln Leu 
    1145                 1150                 1155             


Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn Ile Glu  Pro Ser Val 
    1160                 1165                 1170             


Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys Pro Glu  Ile Glu Ala 
    1175                 1180                 1185             


Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu Pro Gln  Ser Met Val 
    1190                 1195                 1200             


Trp Leu  Pro Val Leu His Arg  Val Ala Ala Ala Glu  Thr Ala Lys 
    1205                 1210                 1215             


His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu Cys Pro  Ile Ile Gly 
    1220                 1225                 1230             


Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn Tyr Asp  Ile Cys Gln 
    1235                 1240                 1245             


Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys Gly His  Lys Met His 
    1250                 1255                 1260             


Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr Thr Ser  Gly Glu Asp 
    1265                 1270                 1275             


Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn Lys Phe  Arg Thr Lys 
    1280                 1285                 1290             


Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly Tyr Leu  Pro Val Gln 
    1295                 1300                 1305             


Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr Asp Thr  Met 
    1310                 1315                 1320     


<210>  120
<211>  1347
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Leu Leu 
        435                 440                 445             


Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu 
    450                 455                 460                 


Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys 
465                 470                 475                 480 


Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys 
                485                 490                 495     


Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu 
            500                 505                 510         


Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys 
        515                 520                 525             


Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val 
    530                 535                 540                 


Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr 
545                 550                 555                 560 


Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr 
                565                 570                 575     


Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu 
            580                 585                 590         


Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu 
        595                 600                 605             


Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu 
    610                 615                 620                 


Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu 
625                 630                 635                 640 


Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn 
                645                 650                 655     


Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu 
            660                 665                 670         


Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg 
        675                 680                 685             


Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr 
    690                 695                 700                 


Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe 
705                 710                 715                 720 


Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe 
                725                 730                 735     


Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile 
            740                 745                 750         


Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln 
        755                 760                 765             


Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu 
    770                 775                 780                 


Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 
785                 790                 795                 800 


Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser 
                805                 810                 815     


Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val 
            820                 825                 830         


Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Lys Asn 
        835                 840                 845             


Ile Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu 
    850                 855                 860                 


Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu 
865                 870                 875                 880 


Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg 
                885                 890                 895     


Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu 
            900                 905                 910         


Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu 
        915                 920                 925             


Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala 
    930                 935                 940                 


Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly 
945                 950                 955                 960 


Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu 
                965                 970                 975     


Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 
            980                 985                 990         


Gln Thr Thr Cys Trp Asp His Pro  Lys Met Thr Glu Leu  Tyr Gln Ser 
        995                 1000                 1005             


Leu Ala  Asp Leu Asn Asn Val  Arg Phe Ser Ala Tyr  Arg Thr Ala 
    1010                 1015                 1020             


Met Lys  Leu Arg Arg Leu Gln  Lys Ala Leu Cys Leu  Asp Leu Leu 
    1025                 1030                 1035             


Ser Leu  Ser Ala Ala Cys Asp  Ala Leu Asp Gln His  Asn Leu Lys 
    1040                 1045                 1050             


Gln Asn  Asp Gln Pro Met Asp  Ile Leu Gln Ile Ile  Asn Cys Leu 
    1055                 1060                 1065             


Thr Thr  Ile Tyr Asp Arg Leu  Glu Gln Glu His Asn  Asn Leu Val 
    1070                 1075                 1080             


Asn Val  Pro Leu Cys Val Asp  Met Cys Leu Asn Trp  Leu Leu Asn 
    1085                 1090                 1095             


Val Tyr  Asp Thr Gly Arg Thr  Gly Arg Ile Arg Val  Leu Ser Phe 
    1100                 1105                 1110             


Lys Thr  Gly Ile Ile Ser Leu  Cys Lys Ala His Leu  Glu Asp Lys 
    1115                 1120                 1125             


Tyr Arg  Tyr Leu Phe Lys Gln  Val Ala Ser Ser Thr  Gly Phe Cys 
    1130                 1135                 1140             


Asp Gln  Arg Arg Leu Gly Leu  Leu Leu His Asp Ser  Ile Gln Ile 
    1145                 1150                 1155             


Pro Arg  Gln Leu Gly Glu Val  Ala Ser Phe Gly Gly  Ser Asn Ile 
    1160                 1165                 1170             


Glu Pro  Ser Val Arg Ser Cys  Phe Gln Phe Ala Asn  Asn Lys Pro 
    1175                 1180                 1185             


Glu Ile  Glu Ala Ala Leu Phe  Leu Asp Trp Met Arg  Leu Glu Pro 
    1190                 1195                 1200             


Gln Ser  Met Val Trp Leu Pro  Val Leu His Arg Val  Ala Ala Ala 
    1205                 1210                 1215             


Glu Thr  Ala Lys His Gln Ala  Lys Cys Asn Ile Cys  Lys Glu Cys 
    1220                 1225                 1230             


Pro Ile  Ile Gly Phe Arg Tyr  Arg Ser Leu Lys His  Phe Asn Tyr 
    1235                 1240                 1245             


Asp Ile  Cys Gln Ser Cys Phe  Phe Ser Gly Arg Val  Ala Lys Gly 
    1250                 1255                 1260             


His Lys  Met His Tyr Pro Met  Val Glu Tyr Cys Thr  Pro Thr Thr 
    1265                 1270                 1275             


Ser Gly  Glu Asp Val Arg Asp  Phe Ala Lys Val Leu  Lys Asn Lys 
    1280                 1285                 1290             


Phe Arg  Thr Lys Arg Tyr Phe  Ala Lys His Pro Arg  Met Gly Tyr 
    1295                 1300                 1305             


Leu Pro  Val Gln Thr Val Leu  Glu Gly Asp Asn Met  Glu Thr Thr 
    1310                 1315                 1320             


Pro Cys  Asp Asp Asp Leu Gly  Arg Ala Met Glu Ser  Leu Val Ser 
    1325                 1330                 1335             


Val Met  Thr Asp Glu Glu Gly  Ala Glu 
    1340                 1345         


<210>  121
<211>  1326
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Leu Leu 
        435                 440                 445             


Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu 
    450                 455                 460                 


Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys 
465                 470                 475                 480 


Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys 
                485                 490                 495     


Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu 
            500                 505                 510         


Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys 
        515                 520                 525             


Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val 
    530                 535                 540                 


Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr 
545                 550                 555                 560 


Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr 
                565                 570                 575     


Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu 
            580                 585                 590         


Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu 
        595                 600                 605             


Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu 
    610                 615                 620                 


Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu 
625                 630                 635                 640 


Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn 
                645                 650                 655     


Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu 
            660                 665                 670         


Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg 
        675                 680                 685             


Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr 
    690                 695                 700                 


Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe 
705                 710                 715                 720 


Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe 
                725                 730                 735     


Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile 
            740                 745                 750         


Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln 
        755                 760                 765             


Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu 
    770                 775                 780                 


Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 
785                 790                 795                 800 


Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser 
                805                 810                 815     


Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val 
            820                 825                 830         


Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Lys Leu 
        835                 840                 845             


Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys 
    850                 855                 860                 


Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp 
865                 870                 875                 880 


Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu 
                885                 890                 895     


Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp 
            900                 905                 910         


Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn 
        915                 920                 925             


Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val 
    930                 935                 940                 


Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe 
945                 950                 955                 960 


Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp 
                965                 970                 975     


Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu 
            980                 985                 990         


Thr Gln Thr Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
        995                 1000                 1005             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    1010                 1015                 1020             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    1025                 1030                 1035             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    1040                 1045                 1050             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    1055                 1060                 1065             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    1070                 1075                 1080             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    1085                 1090                 1095             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    1100                 1105                 1110             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    1115                 1120                 1125             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    1130                 1135                 1140             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    1145                 1150                 1155             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    1160                 1165                 1170             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    1175                 1180                 1185             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    1190                 1195                 1200             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    1205                 1210                 1215             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    1220                 1225                 1230             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    1235                 1240                 1245             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    1250                 1255                 1260             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    1265                 1270                 1275             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    1280                 1285                 1290             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    1295                 1300                 1305             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    1310                 1315                 1320             


Asp Thr  Met 
    1325     


<210>  122
<211>  1328
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Leu Leu 
        435                 440                 445             


Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu 
    450                 455                 460                 


Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys 
465                 470                 475                 480 


Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys 
                485                 490                 495     


Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu 
            500                 505                 510         


Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys 
        515                 520                 525             


Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val 
    530                 535                 540                 


Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr 
545                 550                 555                 560 


Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr 
                565                 570                 575     


Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu 
            580                 585                 590         


Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu 
        595                 600                 605             


Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu 
    610                 615                 620                 


Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu 
625                 630                 635                 640 


Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn 
                645                 650                 655     


Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu 
            660                 665                 670         


Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg 
        675                 680                 685             


Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr 
    690                 695                 700                 


Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe 
705                 710                 715                 720 


Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe 
                725                 730                 735     


Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile 
            740                 745                 750         


Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln 
        755                 760                 765             


Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu 
    770                 775                 780                 


Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 
785                 790                 795                 800 


Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser 
                805                 810                 815     


Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val 
            820                 825                 830         


Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Lys Asn 
        835                 840                 845             


Ile Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp 
    850                 855                 860                 


Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val 
865                 870                 875                 880 


Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys 
                885                 890                 895     


Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val 
            900                 905                 910         


Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro 
        915                 920                 925             


Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu 
    930                 935                 940                 


Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg 
945                 950                 955                 960 


Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly 
                965                 970                 975     


Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn 
            980                 985                 990         


His Glu Thr Gln Thr Thr Cys Trp  Asp His Pro Lys Met  Thr Glu Leu 
        995                 1000                 1005             


Tyr Gln  Ser Leu Ala Asp Leu  Asn Asn Val Arg Phe  Ser Ala Tyr 
    1010                 1015                 1020             


Arg Thr  Ala Met Lys Leu Arg  Arg Leu Gln Lys Ala  Leu Cys Leu 
    1025                 1030                 1035             


Asp Leu  Leu Ser Leu Ser Ala  Ala Cys Asp Ala Leu  Asp Gln His 
    1040                 1045                 1050             


Asn Leu  Lys Gln Asn Asp Gln  Pro Met Asp Ile Leu  Gln Ile Ile 
    1055                 1060                 1065             


Asn Cys  Leu Thr Thr Ile Tyr  Asp Arg Leu Glu Gln  Glu His Asn 
    1070                 1075                 1080             


Asn Leu  Val Asn Val Pro Leu  Cys Val Asp Met Cys  Leu Asn Trp 
    1085                 1090                 1095             


Leu Leu  Asn Val Tyr Asp Thr  Gly Arg Thr Gly Arg  Ile Arg Val 
    1100                 1105                 1110             


Leu Ser  Phe Lys Thr Gly Ile  Ile Ser Leu Cys Lys  Ala His Leu 
    1115                 1120                 1125             


Glu Asp  Lys Tyr Arg Tyr Leu  Phe Lys Gln Val Ala  Ser Ser Thr 
    1130                 1135                 1140             


Gly Phe  Cys Asp Gln Arg Arg  Leu Gly Leu Leu Leu  His Asp Ser 
    1145                 1150                 1155             


Ile Gln  Ile Pro Arg Gln Leu  Gly Glu Val Ala Ser  Phe Gly Gly 
    1160                 1165                 1170             


Ser Asn  Ile Glu Pro Ser Val  Arg Ser Cys Phe Gln  Phe Ala Asn 
    1175                 1180                 1185             


Asn Lys  Pro Glu Ile Glu Ala  Ala Leu Phe Leu Asp  Trp Met Arg 
    1190                 1195                 1200             


Leu Glu  Pro Gln Ser Met Val  Trp Leu Pro Val Leu  His Arg Val 
    1205                 1210                 1215             


Ala Ala  Ala Glu Thr Ala Lys  His Gln Ala Lys Cys  Asn Ile Cys 
    1220                 1225                 1230             


Lys Glu  Cys Pro Ile Ile Gly  Phe Arg Tyr Arg Ser  Leu Lys His 
    1235                 1240                 1245             


Phe Asn  Tyr Asp Ile Cys Gln  Ser Cys Phe Phe Ser  Gly Arg Val 
    1250                 1255                 1260             


Ala Lys  Gly His Lys Met His  Tyr Pro Met Val Glu  Tyr Cys Thr 
    1265                 1270                 1275             


Pro Thr  Thr Ser Gly Glu Asp  Val Arg Asp Phe Ala  Lys Val Leu 
    1280                 1285                 1290             


Lys Asn  Lys Phe Arg Thr Lys  Arg Tyr Phe Ala Lys  His Pro Arg 
    1295                 1300                 1305             


Met Gly  Tyr Leu Pro Val Gln  Thr Val Leu Glu Gly  Asp Asn Met 
    1310                 1315                 1320             


Glu Thr  Asp Thr Met 
    1325             


<210>  123
<211>  1327
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala 
    450                 455                 460                 


Trp Leu Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly 
465                 470                 475                 480 


Phe Lys Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val 
                485                 490                 495     


Leu Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr 
            500                 505                 510         


Ser Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr 
        515                 520                 525             


Gln Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn 
    530                 535                 540                 


Leu Val Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val 
545                 550                 555                 560 


Thr Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val 
                565                 570                 575     


Thr Thr Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu 
            580                 585                 590         


Glu Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp 
        595                 600                 605             


Ser Glu Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val Met 
    610                 615                 620                 


Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu 
625                 630                 635                 640 


Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu 
                645                 650                 655     


Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys 
            660                 665                 670         


Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser 
        675                 680                 685             


Gly Arg Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser 
    690                 695                 700                 


Ala Thr Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu 
705                 710                 715                 720 


Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly 
                725                 730                 735     


Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile 
            740                 745                 750         


Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys 
        755                 760                 765             


Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu 
    770                 775                 780                 


Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr 
785                 790                 795                 800 


Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp 
                805                 810                 815     


Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln 
            820                 825                 830         


Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln 
        835                 840                 845             


Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu 
    850                 855                 860                 


Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly 
865                 870                 875                 880 


Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala 
                885                 890                 895     


Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn 
            900                 905                 910         


Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr 
        915                 920                 925             


Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln 
    930                 935                 940                 


Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp 
945                 950                 955                 960 


Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro 
                965                 970                 975     


Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His 
            980                 985                 990         


Glu Thr Gln Thr Thr Cys Trp Asp  His Pro Lys Met Thr  Glu Leu Tyr 
        995                 1000                 1005             


Gln Ser  Leu Ala Asp Leu Asn  Asn Val Arg Phe Ser  Ala Tyr Arg 
    1010                 1015                 1020             


Thr Ala  Met Lys Leu Arg Arg  Leu Gln Lys Ala Leu  Cys Leu Asp 
    1025                 1030                 1035             


Leu Leu  Ser Leu Ser Ala Ala  Cys Asp Ala Leu Asp  Gln His Asn 
    1040                 1045                 1050             


Leu Lys  Gln Asn Asp Gln Pro  Met Asp Ile Leu Gln  Ile Ile Asn 
    1055                 1060                 1065             


Cys Leu  Thr Thr Ile Tyr Asp  Arg Leu Glu Gln Glu  His Asn Asn 
    1070                 1075                 1080             


Leu Val  Asn Val Pro Leu Cys  Val Asp Met Cys Leu  Asn Trp Leu 
    1085                 1090                 1095             


Leu Asn  Val Tyr Asp Thr Gly  Arg Thr Gly Arg Ile  Arg Val Leu 
    1100                 1105                 1110             


Ser Phe  Lys Thr Gly Ile Ile  Ser Leu Cys Lys Ala  His Leu Glu 
    1115                 1120                 1125             


Asp Lys  Tyr Arg Tyr Leu Phe  Lys Gln Val Ala Ser  Ser Thr Gly 
    1130                 1135                 1140             


Phe Cys  Asp Gln Arg Arg Leu  Gly Leu Leu Leu His  Asp Ser Ile 
    1145                 1150                 1155             


Gln Ile  Pro Arg Gln Leu Gly  Glu Val Ala Ser Phe  Gly Gly Ser 
    1160                 1165                 1170             


Asn Ile  Glu Pro Ser Val Arg  Ser Cys Phe Gln Phe  Ala Asn Asn 
    1175                 1180                 1185             


Lys Pro  Glu Ile Glu Ala Ala  Leu Phe Leu Asp Trp  Met Arg Leu 
    1190                 1195                 1200             


Glu Pro  Gln Ser Met Val Trp  Leu Pro Val Leu His  Arg Val Ala 
    1205                 1210                 1215             


Ala Ala  Glu Thr Ala Lys His  Gln Ala Lys Cys Asn  Ile Cys Lys 
    1220                 1225                 1230             


Glu Cys  Pro Ile Ile Gly Phe  Arg Tyr Arg Ser Leu  Lys His Phe 
    1235                 1240                 1245             


Asn Tyr  Asp Ile Cys Gln Ser  Cys Phe Phe Ser Gly  Arg Val Ala 
    1250                 1255                 1260             


Lys Gly  His Lys Met His Tyr  Pro Met Val Glu Tyr  Cys Thr Pro 
    1265                 1270                 1275             


Thr Thr  Ser Gly Glu Asp Val  Arg Asp Phe Ala Lys  Val Leu Lys 
    1280                 1285                 1290             


Asn Lys  Phe Arg Thr Lys Arg  Tyr Phe Ala Lys His  Pro Arg Met 
    1295                 1300                 1305             


Gly Tyr  Leu Pro Val Gln Thr  Val Leu Glu Gly Asp  Asn Met Glu 
    1310                 1315                 1320             


Thr Asp  Thr Met 
    1325         


<210>  124
<211>  1332
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Leu Gln Asp Ile Leu Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln 
    450                 455                 460                 


Cys Leu Phe Ser Ala Trp Leu Ser Glu Lys Glu Asp Ala Val Asn Lys 
465                 470                 475                 480 


Ile His Thr Thr Gly Phe Lys Asp Gln Asn Glu Met Leu Ser Ser Leu 
                485                 490                 495     


Gln Lys Leu Ala Val Leu Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser 
            500                 505                 510         


Met Gly Lys Leu Tyr Ser Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys 
        515                 520                 525             


Asn Lys Ser Val Thr Gln Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala 
    530                 535                 540                 


Arg Cys Trp Asp Asn Leu Val Gln Lys Leu Glu Lys Ser Thr Ala Gln 
545                 550                 555                 560 


Ile Ser Gln Ala Val Thr Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr 
                565                 570                 575     


Val Met Glu Thr Val Thr Thr Val Thr Thr Arg Glu Gln Ile Leu Val 
            580                 585                 590         


Lys His Ala Gln Glu Glu Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg 
        595                 600                 605             


Gln Ile Thr Val Asp Ser Glu Ala Gln Ile His Thr Val Arg Glu Glu 
    610                 615                 620                 


Thr Met Met Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val 
625                 630                 635                 640 


Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu 
                645                 650                 655     


Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe 
            660                 665                 670         


Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser 
        675                 680                 685             


Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys Thr 
    690                 695                 700                 


Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln Glu 
705                 710                 715                 720 


Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr 
                725                 730                 735     


Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg 
            740                 745                 750         


Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu 
        755                 760                 765             


Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys 
    770                 775                 780                 


Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln 
785                 790                 795                 800 


Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln 
                805                 810                 815     


Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu 
            820                 825                 830         


Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys 
        835                 840                 845             


Arg Leu Glu Glu Gln Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr 
    850                 855                 860                 


Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser 
865                 870                 875                 880 


Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu 
                885                 890                 895     


Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn 
            900                 905                 910         


Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile 
        915                 920                 925             


Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg 
    930                 935                 940                 


Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His 
945                 950                 955                 960 


Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr 
                965                 970                 975     


Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro 
            980                 985                 990         


Tyr Tyr Ile Asn His Glu Thr Gln  Thr Thr Cys Trp Asp  His Pro Lys 
        995                 1000                 1005             


Met Thr  Glu Leu Tyr Gln Ser  Leu Ala Asp Leu Asn  Asn Val Arg 
    1010                 1015                 1020             


Phe Ser  Ala Tyr Arg Thr Ala  Met Lys Leu Arg Arg  Leu Gln Lys 
    1025                 1030                 1035             


Ala Leu  Cys Leu Asp Leu Leu  Ser Leu Ser Ala Ala  Cys Asp Ala 
    1040                 1045                 1050             


Leu Asp  Gln His Asn Leu Lys  Gln Asn Asp Gln Pro  Met Asp Ile 
    1055                 1060                 1065             


Leu Gln  Ile Ile Asn Cys Leu  Thr Thr Ile Tyr Asp  Arg Leu Glu 
    1070                 1075                 1080             


Gln Glu  His Asn Asn Leu Val  Asn Val Pro Leu Cys  Val Asp Met 
    1085                 1090                 1095             


Cys Leu  Asn Trp Leu Leu Asn  Val Tyr Asp Thr Gly  Arg Thr Gly 
    1100                 1105                 1110             


Arg Ile  Arg Val Leu Ser Phe  Lys Thr Gly Ile Ile  Ser Leu Cys 
    1115                 1120                 1125             


Lys Ala  His Leu Glu Asp Lys  Tyr Arg Tyr Leu Phe  Lys Gln Val 
    1130                 1135                 1140             


Ala Ser  Ser Thr Gly Phe Cys  Asp Gln Arg Arg Leu  Gly Leu Leu 
    1145                 1150                 1155             


Leu His  Asp Ser Ile Gln Ile  Pro Arg Gln Leu Gly  Glu Val Ala 
    1160                 1165                 1170             


Ser Phe  Gly Gly Ser Asn Ile  Glu Pro Ser Val Arg  Ser Cys Phe 
    1175                 1180                 1185             


Gln Phe  Ala Asn Asn Lys Pro  Glu Ile Glu Ala Ala  Leu Phe Leu 
    1190                 1195                 1200             


Asp Trp  Met Arg Leu Glu Pro  Gln Ser Met Val Trp  Leu Pro Val 
    1205                 1210                 1215             


Leu His  Arg Val Ala Ala Ala  Glu Thr Ala Lys His  Gln Ala Lys 
    1220                 1225                 1230             


Cys Asn  Ile Cys Lys Glu Cys  Pro Ile Ile Gly Phe  Arg Tyr Arg 
    1235                 1240                 1245             


Ser Leu  Lys His Phe Asn Tyr  Asp Ile Cys Gln Ser  Cys Phe Phe 
    1250                 1255                 1260             


Ser Gly  Arg Val Ala Lys Gly  His Lys Met His Tyr  Pro Met Val 
    1265                 1270                 1275             


Glu Tyr  Cys Thr Pro Thr Thr  Ser Gly Glu Asp Val  Arg Asp Phe 
    1280                 1285                 1290             


Ala Lys  Val Leu Lys Asn Lys  Phe Arg Thr Lys Arg  Tyr Phe Ala 
    1295                 1300                 1305             


Lys His  Pro Arg Met Gly Tyr  Leu Pro Val Gln Thr  Val Leu Glu 
    1310                 1315                 1320             


Gly Asp  Asn Met Glu Thr Asp  Thr Met 
    1325                 1330         


<210>  125
<211>  1325
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Leu Leu 
        435                 440                 445             


Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu 
    450                 455                 460                 


Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys 
465                 470                 475                 480 


Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys 
                485                 490                 495     


Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu 
            500                 505                 510         


Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys 
        515                 520                 525             


Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val 
    530                 535                 540                 


Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr 
545                 550                 555                 560 


Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr 
                565                 570                 575     


Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu 
            580                 585                 590         


Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu 
        595                 600                 605             


Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu 
    610                 615                 620                 


Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu 
625                 630                 635                 640 


Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn 
                645                 650                 655     


Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu 
            660                 665                 670         


Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg 
        675                 680                 685             


Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr 
    690                 695                 700                 


Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe 
705                 710                 715                 720 


Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe 
                725                 730                 735     


Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile 
            740                 745                 750         


Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln 
        755                 760                 765             


Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu 
    770                 775                 780                 


Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 
785                 790                 795                 800 


Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser 
                805                 810                 815     


Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val 
            820                 825                 830         


Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Leu Glu 
        835                 840                 845             


Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu 
    850                 855                 860                 


Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu 
865                 870                 875                 880 


Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg 
                885                 890                 895     


Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu 
            900                 905                 910         


Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu 
        915                 920                 925             


Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala 
    930                 935                 940                 


Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly 
945                 950                 955                 960 


Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu 
                965                 970                 975     


Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 
            980                 985                 990         


Gln Thr Thr Cys Trp Asp His Pro  Lys Met Thr Glu Leu  Tyr Gln Ser 
        995                 1000                 1005             


Leu Ala  Asp Leu Asn Asn Val  Arg Phe Ser Ala Tyr  Arg Thr Ala 
    1010                 1015                 1020             


Met Lys  Leu Arg Arg Leu Gln  Lys Ala Leu Cys Leu  Asp Leu Leu 
    1025                 1030                 1035             


Ser Leu  Ser Ala Ala Cys Asp  Ala Leu Asp Gln His  Asn Leu Lys 
    1040                 1045                 1050             


Gln Asn  Asp Gln Pro Met Asp  Ile Leu Gln Ile Ile  Asn Cys Leu 
    1055                 1060                 1065             


Thr Thr  Ile Tyr Asp Arg Leu  Glu Gln Glu His Asn  Asn Leu Val 
    1070                 1075                 1080             


Asn Val  Pro Leu Cys Val Asp  Met Cys Leu Asn Trp  Leu Leu Asn 
    1085                 1090                 1095             


Val Tyr  Asp Thr Gly Arg Thr  Gly Arg Ile Arg Val  Leu Ser Phe 
    1100                 1105                 1110             


Lys Thr  Gly Ile Ile Ser Leu  Cys Lys Ala His Leu  Glu Asp Lys 
    1115                 1120                 1125             


Tyr Arg  Tyr Leu Phe Lys Gln  Val Ala Ser Ser Thr  Gly Phe Cys 
    1130                 1135                 1140             


Asp Gln  Arg Arg Leu Gly Leu  Leu Leu His Asp Ser  Ile Gln Ile 
    1145                 1150                 1155             


Pro Arg  Gln Leu Gly Glu Val  Ala Ser Phe Gly Gly  Ser Asn Ile 
    1160                 1165                 1170             


Glu Pro  Ser Val Arg Ser Cys  Phe Gln Phe Ala Asn  Asn Lys Pro 
    1175                 1180                 1185             


Glu Ile  Glu Ala Ala Leu Phe  Leu Asp Trp Met Arg  Leu Glu Pro 
    1190                 1195                 1200             


Gln Ser  Met Val Trp Leu Pro  Val Leu His Arg Val  Ala Ala Ala 
    1205                 1210                 1215             


Glu Thr  Ala Lys His Gln Ala  Lys Cys Asn Ile Cys  Lys Glu Cys 
    1220                 1225                 1230             


Pro Ile  Ile Gly Phe Arg Tyr  Arg Ser Leu Lys His  Phe Asn Tyr 
    1235                 1240                 1245             


Asp Ile  Cys Gln Ser Cys Phe  Phe Ser Gly Arg Val  Ala Lys Gly 
    1250                 1255                 1260             


His Lys  Met His Tyr Pro Met  Val Glu Tyr Cys Thr  Pro Thr Thr 
    1265                 1270                 1275             


Ser Gly  Glu Asp Val Arg Asp  Phe Ala Lys Val Leu  Lys Asn Lys 
    1280                 1285                 1290             


Phe Arg  Thr Lys Arg Tyr Phe  Ala Lys His Pro Arg  Met Gly Tyr 
    1295                 1300                 1305             


Leu Pro  Val Gln Thr Val Leu  Glu Gly Asp Asn Met  Glu Thr Asp 
    1310                 1315                 1320             


Thr Met  
    1325 


<210>  126
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Ile His 
        435                 440                 445             


Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu 
    450                 455                 460                 


Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val 
465                 470                 475                 480 


Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu 
                485                 490                 495     


Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys 
            500                 505                 510         


Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile 
        515                 520                 525             


His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg 
    530                 535                 540                 


Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys 
545                 550                 555                 560 


Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 
                565                 570                 575     


Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp 
            580                 585                 590         


Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn 
        595                 600                 605             


Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly 
    610                 615                 620                 


Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu 
625                 630                 635                 640 


Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu 
                645                 650                 655     


Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu 
            660                 665                 670         


Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Ala Pro Gly Leu Thr Thr 
        675                 680                 685             


Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro Val 
    690                 695                 700                 


Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser Ser Leu 
705                 710                 715                 720 


Met Leu Glu Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu 
                725                 730                 735     


Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln 
            740                 745                 750         


Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys 
        755                 760                 765             


Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser 
    770                 775                 780                 


His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu 
785                 790                 795                 800 


Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys 
                805                 810                 815     


Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala 
            820                 825                 830         


His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val 
        835                 840                 845             


Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr 
    850                 855                 860                 


Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr 
865                 870                 875                 880 


Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala 
                885                 890                 895     


Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu 
            900                 905                 910         


Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn 
        915                 920                 925             


Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys 
    930                 935                 940                 


Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu Val 
945                 950                 955                 960 


Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val 
                965                 970                 975     


Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser Phe Lys Thr 
            980                 985                 990         


Gly Ile Ile Ser Leu Cys Lys Ala  His Leu Glu Asp Lys  Tyr Arg Tyr 
        995                 1000                 1005             


Leu Phe  Lys Gln Val Ala Ser  Ser Thr Gly Phe Cys  Asp Gln Arg 
    1010                 1015                 1020             


Arg Leu  Gly Leu Leu Leu His  Asp Ser Ile Gln Ile  Pro Arg Gln 
    1025                 1030                 1035             


Leu Gly  Glu Val Ala Ser Phe  Gly Gly Ser Asn Ile  Glu Pro Ser 
    1040                 1045                 1050             


Val Arg  Ser Cys Phe Gln Phe  Ala Asn Asn Lys Pro  Glu Ile Glu 
    1055                 1060                 1065             


Ala Ala  Leu Phe Leu Asp Trp  Met Arg Leu Glu Pro  Gln Ser Met 
    1070                 1075                 1080             


Val Trp  Leu Pro Val Leu His  Arg Val Ala Ala Ala  Glu Thr Ala 
    1085                 1090                 1095             


Lys His  Gln Ala Lys Cys Asn  Ile Cys Lys Glu Cys  Pro Ile Ile 
    1100                 1105                 1110             


Gly Phe  Arg Tyr Arg Ser Leu  Lys His Phe Asn Tyr  Asp Ile Cys 
    1115                 1120                 1125             


Gln Ser  Cys Phe Phe Ser Gly  Arg Val Ala Lys Gly  His Lys Met 
    1130                 1135                 1140             


His Tyr  Pro Met Val Glu Tyr  Cys Thr Pro Thr Thr  Ser Gly Glu 
    1145                 1150                 1155             


Asp Val  Arg Asp Phe Ala Lys  Val Leu Lys Asn Lys  Phe Arg Thr 
    1160                 1165                 1170             


Lys Arg  Tyr Phe Ala Lys His  Pro Arg Met Gly Tyr  Leu Pro Val 
    1175                 1180                 1185             


Gln Thr  Val Leu Glu Gly Asp  Asn Met Glu Thr Pro  Ala Gln Ile 
    1190                 1195                 1200             


Leu Ile  Ser Leu Glu Ser Glu  Glu Arg Gly Glu Leu  Glu Arg Ile 
    1205                 1210                 1215             


Leu Ala  Asp Leu Glu Glu Glu  Asn Arg Asn Leu Gln  Ala Glu Tyr 
    1220                 1225                 1230             


Asp Arg  Leu Lys Gln Gln His  Glu His Lys Gly Leu  Ser Pro Leu 
    1235                 1240                 1245             


Pro Ser  Pro Pro Asp Thr Met  
    1250                 1255 


<210>  127
<211>  1262
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp 
    450                 455                 460                 


Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile 
465                 470                 475                 480 


Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala 
                485                 490                 495     


Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu 
            500                 505                 510         


Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile 
        515                 520                 525             


Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro 
    530                 535                 540                 


Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln 
545                 550                 555                 560 


Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp 
                565                 570                 575     


Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe 
            580                 585                 590         


Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile 
        595                 600                 605             


Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu 
    610                 615                 620                 


Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala 
625                 630                 635                 640 


Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile 
                645                 650                 655     


Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys 
            660                 665                 670         


Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Lys Asn Asp 
        675                 680                 685             


Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val 
    690                 695                 700                 


Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys 
705                 710                 715                 720 


Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Glu Arg Leu Gln Glu 
                725                 730                 735     


Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu 
            740                 745                 750         


Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser 
        755                 760                 765             


Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala 
    770                 775                 780                 


Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu 
785                 790                 795                 800 


Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 
                805                 810                 815     


Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg 
            820                 825                 830         


Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln 
        835                 840                 845             


His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser 
    850                 855                 860                 


Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys 
865                 870                 875                 880 


Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu 
                885                 890                 895     


Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg 
            900                 905                 910         


Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys 
        915                 920                 925             


Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp 
    930                 935                 940                 


Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu 
945                 950                 955                 960 


Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys 
                965                 970                 975     


Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile 
            980                 985                 990         


Arg Val Leu Ser Phe Lys Thr Gly  Ile Ile Ser Leu Cys  Lys Ala His 
        995                 1000                 1005             


Leu Glu  Asp Lys Tyr Arg Tyr  Leu Phe Lys Gln Val  Ala Ser Ser 
    1010                 1015                 1020             


Thr Gly  Phe Cys Asp Gln Arg  Arg Leu Gly Leu Leu  Leu His Asp 
    1025                 1030                 1035             


Ser Ile  Gln Ile Pro Arg Gln  Leu Gly Glu Val Ala  Ser Phe Gly 
    1040                 1045                 1050             


Gly Ser  Asn Ile Glu Pro Ser  Val Arg Ser Cys Phe  Gln Phe Ala 
    1055                 1060                 1065             


Asn Asn  Lys Pro Glu Ile Glu  Ala Ala Leu Phe Leu  Asp Trp Met 
    1070                 1075                 1080             


Arg Leu  Glu Pro Gln Ser Met  Val Trp Leu Pro Val  Leu His Arg 
    1085                 1090                 1095             


Val Ala  Ala Ala Glu Thr Ala  Lys His Gln Ala Lys  Cys Asn Ile 
    1100                 1105                 1110             


Cys Lys  Glu Cys Pro Ile Ile  Gly Phe Arg Tyr Arg  Ser Leu Lys 
    1115                 1120                 1125             


His Phe  Asn Tyr Asp Ile Cys  Gln Ser Cys Phe Phe  Ser Gly Arg 
    1130                 1135                 1140             


Val Ala  Lys Gly His Lys Met  His Tyr Pro Met Val  Glu Tyr Cys 
    1145                 1150                 1155             


Thr Pro  Thr Thr Ser Gly Glu  Asp Val Arg Asp Phe  Ala Lys Val 
    1160                 1165                 1170             


Leu Lys  Asn Lys Phe Arg Thr  Lys Arg Tyr Phe Ala  Lys His Pro 
    1175                 1180                 1185             


Arg Met  Gly Tyr Leu Pro Val  Gln Thr Val Leu Glu  Gly Asp Asn 
    1190                 1195                 1200             


Met Glu  Thr Pro Ala Gln Ile  Leu Ile Ser Leu Glu  Ser Glu Glu 
    1205                 1210                 1215             


Arg Gly  Glu Leu Glu Arg Ile  Leu Ala Asp Leu Glu  Glu Glu Asn 
    1220                 1225                 1230             


Arg Asn  Leu Gln Ala Glu Tyr  Asp Arg Leu Lys Gln  Gln His Glu 
    1235                 1240                 1245             


His Lys  Gly Leu Ser Pro Leu  Pro Ser Pro Pro Asp  Thr Met 
    1250                 1255                 1260         


<210>  128
<211>  1249
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Ser Tyr 
        435                 440                 445             


Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu 
    450                 455                 460                 


Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp 
465                 470                 475                 480 


Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 
                485                 490                 495     


Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys 
            500                 505                 510         


Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln 
        515                 520                 525             


Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met 
    530                 535                 540                 


Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg 
545                 550                 555                 560 


Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala 
                565                 570                 575     


Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala 
            580                 585                 590         


Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg 
        595                 600                 605             


Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln 
    610                 615                 620                 


Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser 
625                 630                 635                 640 


Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys 
                645                 650                 655     


Lys Arg Leu Glu Glu Gln Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu 
            660                 665                 670         


Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu 
        675                 680                 685             


Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn 
    690                 695                 700                 


Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg 
705                 710                 715                 720 


Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg 
                725                 730                 735     


Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu 
            740                 745                 750         


Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly 
        755                 760                 765             


Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala 
    770                 775                 780                 


Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser 
785                 790                 795                 800 


Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val 
                805                 810                 815     


Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro 
            820                 825                 830         


Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg 
        835                 840                 845             


Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln 
    850                 855                 860                 


Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu 
865                 870                 875                 880 


Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys 
                885                 890                 895     


Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser 
            900                 905                 910         


Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln 
        915                 920                 925             


Pro Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp 
    930                 935                 940                 


Arg Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val 
945                 950                 955                 960 


Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr 
                965                 970                 975     


Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys 
            980                 985                 990         


Lys Ala His Leu Glu Asp Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala 
        995                 1000                 1005             


Ser Ser  Thr Gly Phe Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu 
    1010                 1015                 1020             


His Asp  Ser Ile Gln Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser 
    1025                 1030                 1035             


Phe Gly  Gly Ser Asn Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln 
    1040                 1045                 1050             


Phe Ala  Asn Asn Lys Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp 
    1055                 1060                 1065             


Trp Met  Arg Leu Glu Pro Gln  Ser Met Val Trp Leu  Pro Val Leu 
    1070                 1075                 1080             


His Arg  Val Ala Ala Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys 
    1085                 1090                 1095             


Asn Ile  Cys Lys Glu Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser 
    1100                 1105                 1110             


Leu Lys  His Phe Asn Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser 
    1115                 1120                 1125             


Gly Arg  Val Ala Lys Gly His  Lys Met His Tyr Pro  Met Val Glu 
    1130                 1135                 1140             


Tyr Cys  Thr Pro Thr Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala 
    1145                 1150                 1155             


Lys Val  Leu Lys Asn Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys 
    1160                 1165                 1170             


His Pro  Arg Met Gly Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly 
    1175                 1180                 1185             


Asp Asn  Met Glu Thr Pro Ala  Gln Ile Leu Ile Ser  Leu Glu Ser 
    1190                 1195                 1200             


Glu Glu  Arg Gly Glu Leu Glu  Arg Ile Leu Ala Asp  Leu Glu Glu 
    1205                 1210                 1215             


Glu Asn  Arg Asn Leu Gln Ala  Glu Tyr Asp Arg Leu  Lys Gln Gln 
    1220                 1225                 1230             


His Glu  His Lys Gly Leu Ser  Pro Leu Pro Ser Pro  Pro Asp Thr 
    1235                 1240                 1245             


Met 
    


<210>  129
<211>  1374
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Leu Leu 
        435                 440                 445             


Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu 
    450                 455                 460                 


Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys 
465                 470                 475                 480 


Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys 
                485                 490                 495     


Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu 
            500                 505                 510         


Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys 
        515                 520                 525             


Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val 
    530                 535                 540                 


Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr 
545                 550                 555                 560 


Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr 
                565                 570                 575     


Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu 
            580                 585                 590         


Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ile His 
        595                 600                 605             


Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu 
    610                 615                 620                 


Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val 
625                 630                 635                 640 


Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu 
                645                 650                 655     


Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys 
            660                 665                 670         


Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile 
        675                 680                 685             


His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg 
    690                 695                 700                 


Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys 
705                 710                 715                 720 


Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 
                725                 730                 735     


Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp 
            740                 745                 750         


Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn 
        755                 760                 765             


Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly 
    770                 775                 780                 


Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu 
785                 790                 795                 800 


Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu 
                805                 810                 815     


Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu 
            820                 825                 830         


Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Leu Glu Arg Leu Gln Glu 
        835                 840                 845             


Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu 
    850                 855                 860                 


Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser 
865                 870                 875                 880 


Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala 
                885                 890                 895     


Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu 
            900                 905                 910         


Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu 
        915                 920                 925             


Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg 
    930                 935                 940                 


Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln 
945                 950                 955                 960 


His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser 
                965                 970                 975     


Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys 
            980                 985                 990         


Trp Asp His Pro Lys Met Thr Glu  Leu Tyr Gln Ser Leu  Ala Asp Leu 
        995                 1000                 1005             


Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr Ala Met  Lys Leu Arg 
    1010                 1015                 1020             


Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu Leu Ser  Leu Ser Ala 
    1025                 1030                 1035             


Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu Lys Gln  Asn Asp Gln 
    1040                 1045                 1050             


Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys Leu Thr  Thr Ile Tyr 
    1055                 1060                 1065             


Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu Val Asn  Val Pro Leu 
    1070                 1075                 1080             


Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu Asn Val  Tyr Asp Thr 
    1085                 1090                 1095             


Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser Phe Lys  Thr Gly Ile 
    1100                 1105                 1110             


Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp Lys Tyr  Arg Tyr Leu 
    1115                 1120                 1125             


Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe Cys Asp  Gln Arg Arg 
    1130                 1135                 1140             


Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln Ile Pro  Arg Gln Leu 
    1145                 1150                 1155             


Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn Ile Glu  Pro Ser Val 
    1160                 1165                 1170             


Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys Pro Glu  Ile Glu Ala 
    1175                 1180                 1185             


Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu Pro Gln  Ser Met Val 
    1190                 1195                 1200             


Trp Leu  Pro Val Leu His Arg  Val Ala Ala Ala Glu  Thr Ala Lys 
    1205                 1210                 1215             


His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu Cys Pro  Ile Ile Gly 
    1220                 1225                 1230             


Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn Tyr Asp  Ile Cys Gln 
    1235                 1240                 1245             


Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys Gly His  Lys Met His 
    1250                 1255                 1260             


Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr Thr Ser  Gly Glu Asp 
    1265                 1270                 1275             


Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn Lys Phe  Arg Thr Lys 
    1280                 1285                 1290             


Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly Tyr Leu  Pro Val Gln 
    1295                 1300                 1305             


Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr Pro Ala  Gln Ile Leu 
    1310                 1315                 1320             


Ile Ser  Leu Glu Ser Glu Glu  Arg Gly Glu Leu Glu  Arg Ile Leu 
    1325                 1330                 1335             


Ala Asp  Leu Glu Glu Glu Asn  Arg Asn Leu Gln Ala  Glu Tyr Asp 
    1340                 1345                 1350             


Arg Leu  Lys Gln Gln His Glu  His Lys Gly Leu Ser  Pro Leu Pro 
    1355                 1360                 1365             


Ser Pro  Pro Asp Thr Met 
    1370                 


<210>  130
<211>  1365
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Ile His 
        435                 440                 445             


Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu 
    450                 455                 460                 


Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val 
465                 470                 475                 480 


Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu 
                485                 490                 495     


Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys 
            500                 505                 510         


Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile 
        515                 520                 525             


His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg 
    530                 535                 540                 


Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys 
545                 550                 555                 560 


Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 
                565                 570                 575     


Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp 
            580                 585                 590         


Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn 
        595                 600                 605             


Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly 
    610                 615                 620                 


Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu 
625                 630                 635                 640 


Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu 
                645                 650                 655     


Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu 
            660                 665                 670         


Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Ala Pro Gly Leu Thr Thr 
        675                 680                 685             


Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro Val 
    690                 695                 700                 


Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser Ser Leu 
705                 710                 715                 720 


Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala Trp Thr Glu 
                725                 730                 735     


Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile Lys Ser Gln Arg 
            740                 745                 750         


Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu Met Ile Ile Lys Gln 
        755                 760                 765             


Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg Pro Gln Leu Glu Glu 
    770                 775                 780                 


Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln Glu 
785                 790                 795                 800 


Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg Ile Gln Asn Gln Trp 
                805                 810                 815     


Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg Gln Gln Leu Asn Glu 
            820                 825                 830         


Met Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp 
        835                 840                 845             


Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val 
    850                 855                 860                 


Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys 
865                 870                 875                 880 


Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val 
                885                 890                 895     


Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro 
            900                 905                 910         


Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu 
        915                 920                 925             


Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg 
    930                 935                 940                 


Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly 
945                 950                 955                 960 


Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn 
                965                 970                 975     


His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu 
            980                 985                 990         


Tyr Gln Ser Leu Ala Asp Leu Asn  Asn Val Arg Phe Ser  Ala Tyr Arg 
        995                 1000                 1005             


Thr Ala  Met Lys Leu Arg Arg  Leu Gln Lys Ala Leu  Cys Leu Asp 
    1010                 1015                 1020             


Leu Leu  Ser Leu Ser Ala Ala  Cys Asp Ala Leu Asp  Gln His Asn 
    1025                 1030                 1035             


Leu Lys  Gln Asn Asp Gln Pro  Met Asp Ile Leu Gln  Ile Ile Asn 
    1040                 1045                 1050             


Cys Leu  Thr Thr Ile Tyr Asp  Arg Leu Glu Gln Glu  His Asn Asn 
    1055                 1060                 1065             


Leu Val  Asn Val Pro Leu Cys  Val Asp Met Cys Leu  Asn Trp Leu 
    1070                 1075                 1080             


Leu Asn  Val Tyr Asp Thr Gly  Arg Thr Gly Arg Ile  Arg Val Leu 
    1085                 1090                 1095             


Ser Phe  Lys Thr Gly Ile Ile  Ser Leu Cys Lys Ala  His Leu Glu 
    1100                 1105                 1110             


Asp Lys  Tyr Arg Tyr Leu Phe  Lys Gln Val Ala Ser  Ser Thr Gly 
    1115                 1120                 1125             


Phe Cys  Asp Gln Arg Arg Leu  Gly Leu Leu Leu His  Asp Ser Ile 
    1130                 1135                 1140             


Gln Ile  Pro Arg Gln Leu Gly  Glu Val Ala Ser Phe  Gly Gly Ser 
    1145                 1150                 1155             


Asn Ile  Glu Pro Ser Val Arg  Ser Cys Phe Gln Phe  Ala Asn Asn 
    1160                 1165                 1170             


Lys Pro  Glu Ile Glu Ala Ala  Leu Phe Leu Asp Trp  Met Arg Leu 
    1175                 1180                 1185             


Glu Pro  Gln Ser Met Val Trp  Leu Pro Val Leu His  Arg Val Ala 
    1190                 1195                 1200             


Ala Ala  Glu Thr Ala Lys His  Gln Ala Lys Cys Asn  Ile Cys Lys 
    1205                 1210                 1215             


Glu Cys  Pro Ile Ile Gly Phe  Arg Tyr Arg Ser Leu  Lys His Phe 
    1220                 1225                 1230             


Asn Tyr  Asp Ile Cys Gln Ser  Cys Phe Phe Ser Gly  Arg Val Ala 
    1235                 1240                 1245             


Lys Gly  His Lys Met His Tyr  Pro Met Val Glu Tyr  Cys Thr Pro 
    1250                 1255                 1260             


Thr Thr  Ser Gly Glu Asp Val  Arg Asp Phe Ala Lys  Val Leu Lys 
    1265                 1270                 1275             


Asn Lys  Phe Arg Thr Lys Arg  Tyr Phe Ala Lys His  Pro Arg Met 
    1280                 1285                 1290             


Gly Tyr  Leu Pro Val Gln Thr  Val Leu Glu Gly Asp  Asn Met Glu 
    1295                 1300                 1305             


Thr Pro  Ala Gln Ile Leu Ile  Ser Leu Glu Ser Glu  Glu Arg Gly 
    1310                 1315                 1320             


Glu Leu  Glu Arg Ile Leu Ala  Asp Leu Glu Glu Glu  Asn Arg Asn 
    1325                 1330                 1335             


Leu Gln  Ala Glu Tyr Asp Arg  Leu Lys Gln Gln His  Glu His Lys 
    1340                 1345                 1350             


Gly Leu  Ser Pro Leu Pro Ser  Pro Pro Asp Thr Met  
    1355                 1360                 1365 


<210>  131
<211>  1383
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Ile His Thr Val 
            660                 665                 670         


Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu Glu Ile 
        675                 680                 685             


Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln 
    690                 695                 700                 


Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala 
705                 710                 715                 720 


Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile 
                725                 730                 735     


Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser 
            740                 745                 750         


Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys 
        755                 760                 765             


Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn 
    770                 775                 780                 


Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu Lys 
785                 790                 795                 800 


Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr 
                805                 810                 815     


Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu 
            820                 825                 830         


His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile Gly 
        835                 840                 845             


Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile 
    850                 855                 860                 


Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu 
865                 870                 875                 880 


Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp 
                885                 890                 895     


Arg Lys Lys Arg Leu Glu Glu Gln Leu Glu Arg Leu Gln Glu Leu Gln 
            900                 905                 910         


Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile 
        915                 920                 925             


Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln 
    930                 935                 940                 


Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 
945                 950                 955                 960 


Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr 
                965                 970                 975     


Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu 
            980                 985                 990         


Asn Thr Arg Trp Lys Leu Leu Gln  Val Ala Val Glu Asp  Arg Val Arg 
        995                 1000                 1005             


Gln Leu  His Glu Ala His Arg  Asp Phe Gly Pro Ala  Ser Gln His 
    1010                 1015                 1020             


Phe Leu  Ser Thr Ser Val Gln  Gly Pro Trp Glu Arg  Ala Ile Ser 
    1025                 1030                 1035             


Pro Asn  Lys Val Pro Tyr Tyr  Ile Asn His Glu Thr  Gln Thr Thr 
    1040                 1045                 1050             


Cys Trp  Asp His Pro Lys Met  Thr Glu Leu Tyr Gln  Ser Leu Ala 
    1055                 1060                 1065             


Asp Leu  Asn Asn Val Arg Phe  Ser Ala Tyr Arg Thr  Ala Met Lys 
    1070                 1075                 1080             


Leu Arg  Arg Leu Gln Lys Ala  Leu Cys Leu Asp Leu  Leu Ser Leu 
    1085                 1090                 1095             


Ser Ala  Ala Cys Asp Ala Leu  Asp Gln His Asn Leu  Lys Gln Asn 
    1100                 1105                 1110             


Asp Gln  Pro Met Asp Ile Leu  Gln Ile Ile Asn Cys  Leu Thr Thr 
    1115                 1120                 1125             


Ile Tyr  Asp Arg Leu Glu Gln  Glu His Asn Asn Leu  Val Asn Val 
    1130                 1135                 1140             


Pro Leu  Cys Val Asp Met Cys  Leu Asn Trp Leu Leu  Asn Val Tyr 
    1145                 1150                 1155             


Asp Thr  Gly Arg Thr Gly Arg  Ile Arg Val Leu Ser  Phe Lys Thr 
    1160                 1165                 1170             


Gly Ile  Ile Ser Leu Cys Lys  Ala His Leu Glu Asp  Lys Tyr Arg 
    1175                 1180                 1185             


Tyr Leu  Phe Lys Gln Val Ala  Ser Ser Thr Gly Phe  Cys Asp Gln 
    1190                 1195                 1200             


Arg Arg  Leu Gly Leu Leu Leu  His Asp Ser Ile Gln  Ile Pro Arg 
    1205                 1210                 1215             


Gln Leu  Gly Glu Val Ala Ser  Phe Gly Gly Ser Asn  Ile Glu Pro 
    1220                 1225                 1230             


Ser Val  Arg Ser Cys Phe Gln  Phe Ala Asn Asn Lys  Pro Glu Ile 
    1235                 1240                 1245             


Glu Ala  Ala Leu Phe Leu Asp  Trp Met Arg Leu Glu  Pro Gln Ser 
    1250                 1255                 1260             


Met Val  Trp Leu Pro Val Leu  His Arg Val Ala Ala  Ala Glu Thr 
    1265                 1270                 1275             


Ala Lys  His Gln Ala Lys Cys  Asn Ile Cys Lys Glu  Cys Pro Ile 
    1280                 1285                 1290             


Ile Gly  Phe Arg Tyr Arg Ser  Leu Lys His Phe Asn  Tyr Asp Ile 
    1295                 1300                 1305             


Cys Gln  Ser Cys Phe Phe Ser  Gly Arg Val Ala Lys  Gly His Lys 
    1310                 1315                 1320             


Met His  Tyr Pro Met Val Glu  Tyr Cys Thr Pro Thr  Thr Ser Gly 
    1325                 1330                 1335             


Glu Asp  Val Arg Asp Phe Ala  Lys Val Leu Lys Asn  Lys Phe Arg 
    1340                 1345                 1350             


Thr Lys  Arg Tyr Phe Ala Lys  His Pro Arg Met Gly  Tyr Leu Pro 
    1355                 1360                 1365             


Val Gln  Thr Val Leu Glu Gly  Asp Asn Met Glu Thr  Asp Thr Met 
    1370                 1375                 1380             


<210>  132
<211>  1384
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Ile His 
        435                 440                 445             


Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu 
    450                 455                 460                 


Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val 
465                 470                 475                 480 


Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu 
                485                 490                 495     


Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys 
            500                 505                 510         


Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile 
        515                 520                 525             


His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg 
    530                 535                 540                 


Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys 
545                 550                 555                 560 


Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 
                565                 570                 575     


Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp 
            580                 585                 590         


Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn 
        595                 600                 605             


Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly 
    610                 615                 620                 


Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu 
625                 630                 635                 640 


Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu 
                645                 650                 655     


Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu 
            660                 665                 670         


Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Ala Pro Gly Leu Thr Thr 
        675                 680                 685             


Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro Val 
    690                 695                 700                 


Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser Ser Leu 
705                 710                 715                 720 


Met Leu Glu Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu 
                725                 730                 735     


Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala 
            740                 745                 750         


Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His 
        755                 760                 765             


Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser 
    770                 775                 780                 


Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly 
785                 790                 795                 800 


Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg 
                805                 810                 815     


Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn 
            820                 825                 830         


Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys 
        835                 840                 845             


Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp 
    850                 855                 860                 


Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp 
865                 870                 875                 880 


Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu 
                885                 890                 895     


Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val 
            900                 905                 910         


Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln 
        915                 920                 925             


Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp 
    930                 935                 940                 


Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu 
945                 950                 955                 960 


Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser 
                965                 970                 975     


Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr 
            980                 985                 990         


Tyr Ile Asn His Glu Thr Gln Thr  Thr Cys Trp Asp His  Pro Lys Met 
        995                 1000                 1005             


Thr Glu  Leu Tyr Gln Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe 
    1010                 1015                 1020             


Ser Ala  Tyr Arg Thr Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala 
    1025                 1030                 1035             


Leu Cys  Leu Asp Leu Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu 
    1040                 1045                 1050             


Asp Gln  His Asn Leu Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu 
    1055                 1060                 1065             


Gln Ile  Ile Asn Cys Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln 
    1070                 1075                 1080             


Glu His  Asn Asn Leu Val Asn  Val Pro Leu Cys Val  Asp Met Cys 
    1085                 1090                 1095             


Leu Asn  Trp Leu Leu Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg 
    1100                 1105                 1110             


Ile Arg  Val Leu Ser Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys 
    1115                 1120                 1125             


Ala His  Leu Glu Asp Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala 
    1130                 1135                 1140             


Ser Ser  Thr Gly Phe Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu 
    1145                 1150                 1155             


His Asp  Ser Ile Gln Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser 
    1160                 1165                 1170             


Phe Gly  Gly Ser Asn Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln 
    1175                 1180                 1185             


Phe Ala  Asn Asn Lys Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp 
    1190                 1195                 1200             


Trp Met  Arg Leu Glu Pro Gln  Ser Met Val Trp Leu  Pro Val Leu 
    1205                 1210                 1215             


His Arg  Val Ala Ala Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys 
    1220                 1225                 1230             


Asn Ile  Cys Lys Glu Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser 
    1235                 1240                 1245             


Leu Lys  His Phe Asn Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser 
    1250                 1255                 1260             


Gly Arg  Val Ala Lys Gly His  Lys Met His Tyr Pro  Met Val Glu 
    1265                 1270                 1275             


Tyr Cys  Thr Pro Thr Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala 
    1280                 1285                 1290             


Lys Val  Leu Lys Asn Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys 
    1295                 1300                 1305             


His Pro  Arg Met Gly Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly 
    1310                 1315                 1320             


Asp Asn  Met Glu Thr Pro Ala  Gln Ile Leu Ile Ser  Leu Glu Ser 
    1325                 1330                 1335             


Glu Glu  Arg Gly Glu Leu Glu  Arg Ile Leu Ala Asp  Leu Glu Glu 
    1340                 1345                 1350             


Glu Asn  Arg Asn Leu Gln Ala  Glu Tyr Asp Arg Leu  Lys Gln Gln 
    1355                 1360                 1365             


His Glu  His Lys Gly Leu Ser  Pro Leu Pro Ser Pro  Pro Asp Thr 
    1370                 1375                 1380             


Met 
    


<210>  133
<211>  4152
<212>  DNA
<213>  Homo sapiens

<400>  133
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggccc agggctacga gagaaccagc agccccaagc cccggttcaa gagctacgcc      900

tatacccagg ccgcctacgt gaccaccagc gaccctacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgagct ggctgctgag cgccgaggat     1080

acactgcagg ctcagggcga gatcagcaac gacgtggaag tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg caacatcctg     1200

cagctgggct ccaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcatag ggtcctgctg aagtggcagc ggctgaccga ggaacagtgc     1380

ctgtttagcg cctggctgtc cgagaaagag gacgccgtga acaagatcca caccaccggc     1440

ttcaaggacc agaacgagat gctgagcagc ctgcagaaac tggccgtgct gaaggccgac     1500

ctggaaaaga aaaagcagtc catgggcaag ctgtactccc tgaagcagga cctgctgtcc     1560

accctgaaga acaagagcgt gacccagaaa accgaggcct ggctggacaa cttcgcccgg     1620

tgctgggaca acctggtgca gaagctggaa aagtccaccg cccagatctc ccaggccgtg     1680

accacaacac agcccagcct gacccagacc accgtgatgg aaaccgtgac aacagtgacc     1740

acccgggaac agatcctcgt gaagcacgcc caggaagaac tgccccctcc acccccccag     1800

aagaaacggc agatcacagt ggacagtgaa gctcagatcc acaccgtgcg ggaagagaca     1860

atgatggtca tgacagagga catgcccctg gaaatcagct acgtgcccag cacctacctg     1920

accgagatca cccatgtgtc ccaggccctg ctggaagtgg aacagctgct gaacgccccc     1980

gacctgtgcg ccaaggattt cgaggacctg ttcaagcagg aagagagcct gaagaatatc     2040

aaggatagcc tgcagcagag cagcggccgg atcgacatca tccacagcaa gaaaacagcc     2100

gccctgcaga gcgccacccc cgtggaaaga gtgaaactgc aggaagccct gtcccagctg     2160

gacttccagt gggagaaagt gaacaaaatg tacaaggacc ggcagggcag attcgaccgc     2220

agcgtggaaa agtggcggcg gttccactac gacatcaaga tcttcaacca gtggctgaca     2280

gaggccgagc agttcctgag aaagacccag atccccgaga actgggagca cgccaagtac     2340

aagtggtatc tgaaagagct gcaggacggc atcggccaga gacagacagt cgtgcggacc     2400

ctgaatgcca ccggcgagga aatcatccag cagtccagca agaccgacgc cagcattctg     2460

caggaaaagc tgggcagcct gaacctgcgg tggcaggaag tgtgcaagca gctgtccgac     2520

cggaagaagc ggctggaaga acagctggaa cggctgcagg aactgcagga ggccaccgac     2580

gagctggacc tgaaactgag acaggccgaa gtgatcaagg gcagctggca gccagtgggc     2640

gacctgctga tcgactccct gcaggaccat ctggaaaaag tgaaggccct gagaggcgag     2700

atcgcccccc tgaaagaaaa cgtgtcccac gtgaacgacc tggcccggca gctgacaaca     2760

ctgggcattc agctgagccc ctacaacctg agcacactgg aagatctgaa cacccggtgg     2820

aagctgctgc aggtggccgt ggaagataga gtgcggcagc tgcacgaggc ccacagagat     2880

tttggccctg cctcccagca cttcctgagc accagtgtgc agggcccttg ggagagagcc     2940

atctccccta acaaggtgcc ctactacatc aaccacgaga cacagaccac ctgttgggac     3000

caccccaaga tgaccgagct gtaccagagc ctggctgacc tgaacaacgt gcggttcagc     3060

gcctaccgga ccgccatgaa gctgcggaga ctgcagaaag ctctgtgcct ggatctgctg     3120

tccctgtccg ccgcctgtga tgccctggac cagcacaatc tgaagcagaa cgaccagccc     3180

atggatatcc tgcagatcat caactgcctg accaccatct acgaccggct ggaacaggaa     3240

cacaacaatc tcgtgaacgt gcccctgtgc gtggacatgt gcctgaattg gctgctgaat     3300

gtgtacgaca ccggccggac aggccggatc agagtgctgt ccttcaagac cggcatcatc     3360

agcctgtgca aagcccacct ggaagataag taccggtatc tgttcaaaca ggtggcctct     3420

agcaccggct tttgcgacca gagaaggctg ggcctgctgc tgcacgacag catccagatc     3480

cctagacagc tgggcgaagt ggccagcttt ggcggcagca acatcgagcc tagcgtgcgg     3540

agctgcttcc agttcgccaa caacaagccc gagatcgagg ccgccctgtt cctggactgg     3600

atgagactgg aaccccagag catggtgtgg ctgcccgtgc tgcatagagt ggccgctgcc     3660

gagacagcca agcaccaggc caagtgcaac atctgcaaag agtgccccat catcggcttc     3720

cggtacagaa gcctgaagca cttcaactac gatatctgcc agagctgttt cttcagcggc     3780

agggtggcca agggccacaa aatgcactac cccatggtgg aatactgcac ccccaccaca     3840

agcggcgagg atgtgcggga tttcgccaag gtgctgaaaa acaagttccg gaccaagcgg     3900

tacttcgcca aacacccccg gatgggctac ctgcctgtgc agacagtgct ggaaggcgac     3960

aacatggaaa ccgacaccat gtgatgatga tttgggcaga gcgatggagt ccttagtatc     4020

agtcatgaca gatgaagaag gagcagaata aatgttttac aactcctgat tcccgcatgc     4080

ggccagctta tcgataccgt cgaaataaaa gatccttatt ttcattggat ctgtgtgttg     4140

gttttttgtg tg                                                         4152


<210>  134
<211>  4134
<212>  DNA
<213>  Homo sapiens

<400>  134
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggccc agggctacga gagaaccagc agccccaagc cccggttcaa gagctacgcc      900

tatacccagg ccgcctacgt gaccaccagc gaccctacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgagct ggctgctgag cgccgaggat     1080

acactgcagg ctcagggcga gatcagcaac gacgtggaag tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg caacatcctg     1200

cagctgggct ccaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcatct gctgaagtgg cagcggctga ccgaggaaca gtgcctgttt     1380

agcgcctggc tgtccgagaa agaggacgcc gtgaacaaga tccacaccac cggcttcaag     1440

gaccagaacg agatgctgag cagcctgcag aaactggccg tgctgaaggc cgacctggaa     1500

aagaaaaagc agtccatggg caagctgtac tccctgaagc aggacctgct gtccaccctg     1560

aagaacaaga gcgtgaccca gaaaaccgag gcctggctgg acaacttcgc ccggtgctgg     1620

gacaacctgg tgcagaagct ggaaaagtcc accgcccaga tctcccaggc cgtgaccaca     1680

acacagccca gcctgaccca gaccaccgtg atggaaaccg tgacaacagt gaccacccgg     1740

gaacagatcc tcgtgaagca cgcccaggaa gaactgcccc ctccaccccc ccagaagaaa     1800

cggcagatca cagtggacat ccacaccgtg cgggaagaga caatgatggt catgacagag     1860

gacatgcccc tggaaatcag ctacgtgccc agcacctacc tgaccgagat cacccatgtg     1920

tcccaggccc tgctggaagt ggaacagctg ctgaacgccc ccgacctgtg cgccaaggat     1980

ttcgaggacc tgttcaagca ggaagagagc ctgaagaata tcaaggatag cctgcagcag     2040

agcagcggcc ggatcgacat catccacagc aagaaaacag ccgccctgca gagcgccacc     2100

cccgtggaaa gagtgaaact gcaggaagcc ctgtcccagc tggacttcca gtgggagaaa     2160

gtgaacaaaa tgtacaagga ccggcagggc agattcgacc gcagcgtgga aaagtggcgg     2220

cggttccact acgacatcaa gatcttcaac cagtggctga cagaggccga gcagttcctg     2280

agaaagaccc agatccccga gaactgggag cacgccaagt acaagtggta tctgaaagag     2340

ctgcaggacg gcatcggcca gagacagaca gtcgtgcgga ccctgaatgc caccggcgag     2400

gaaatcatcc agcagtccag caagaccgac gccagcattc tgcaggaaaa gctgggcagc     2460

ctgaacctgc ggtggcagga agtgtgcaag cagctgtccg accggaagaa gcggctggaa     2520

gaacagctgg aacggctgca ggaactgcag gaggccaccg acgagctgga cctgaaactg     2580

agacaggccg aagtgatcaa gggcagctgg cagccagtgg gcgacctgct gatcgactcc     2640

ctgcaggacc atctggaaaa agtgaaggcc ctgagaggcg agatcgcccc cctgaaagaa     2700

aacgtgtccc acgtgaacga cctggcccgg cagctgacaa cactgggcat tcagctgagc     2760

ccctacaacc tgagcacact ggaagatctg aacacccggt ggaagctgct gcaggtggcc     2820

gtggaagata gagtgcggca gctgcacgag gcccacagag attttggccc tgcctcccag     2880

cacttcctga gcaccagtgt gcagggccct tgggagagag ccatctcccc taacaaggtg     2940

ccctactaca tcaaccacga gacacagacc acctgttggg accaccccaa gatgaccgag     3000

ctgtaccaga gcctggctga cctgaacaac gtgcggttca gcgcctaccg gaccgccatg     3060

aagctgcgga gactgcagaa agctctgtgc ctggatctgc tgtccctgtc cgccgcctgt     3120

gatgccctgg accagcacaa tctgaagcag aacgaccagc ccatggatat cctgcagatc     3180

atcaactgcc tgaccaccat ctacgaccgg ctggaacagg aacacaacaa tctcgtgaac     3240

gtgcccctgt gcgtggacat gtgcctgaat tggctgctga atgtgtacga caccggccgg     3300

acaggccgga tcagagtgct gtccttcaag accggcatca tcagcctgtg caaagcccac     3360

ctggaagata agtaccggta tctgttcaaa caggtggcct ctagcaccgg cttttgcgac     3420

cagagaaggc tgggcctgct gctgcacgac agcatccaga tccctagaca gctgggcgaa     3480

gtggccagct ttggcggcag caacatcgag cctagcgtgc ggagctgctt ccagttcgcc     3540

aacaacaagc ccgagatcga ggccgccctg ttcctggact ggatgagact ggaaccccag     3600

agcatggtgt ggctgcccgt gctgcataga gtggccgctg ccgagacagc caagcaccag     3660

gccaagtgca acatctgcaa agagtgcccc atcatcggct tccggtacag aagcctgaag     3720

cacttcaact acgatatctg ccagagctgt ttcttcagcg gcagggtggc caagggccac     3780

aaaatgcact accccatggt ggaatactgc acccccacca caagcggcga ggatgtgcgg     3840

gatttcgcca aggtgctgaa aaacaagttc cggaccaagc ggtacttcgc caaacacccc     3900

cggatgggct acctgcctgt gcagacagtg ctggaaggcg acaacatgga aaccgacacc     3960

atgtgatgat gatttgggca gagcgatgga gtccttagta tcagtcatga cagatgaaga     4020

aggagcagaa taaatgtttt acaactcctg attcccgcat gcggccagct tatcgatacc     4080

gtcgaaataa aagatcctta ttttcattgg atctgtgtgt tggttttttg tgtg           4134


<210>  135
<211>  4145
<212>  DNA
<213>  Homo sapiens

<400>  135
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggccc agggctacga gagaaccagc agccccaagc cccggttcaa gagctacgcc      900

tatacccagg ccgcctacgt gaccaccagc gaccctacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgagct ggctgctgag cgccgaggat     1080

acactgcagg ctcagggcga gatcagcaac gacgtggaag tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg caacatcctg     1200

cagctgggct ccaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcatct gctgaagtgg cagcggctga ccgaggaaca gtgcctgttt     1380

agcgcctggc tgtccgagaa agaggacgcc gtgaacaaga tccacaccac cggcttcaag     1440

gaccagaacg agatgctgag cagcctgcag aaactggccg tgctgaaggc cgacctggaa     1500

aagaaaaagc agtccatggg caagctgtac tccctgaagc aggacctgct gtccaccctg     1560

aagaacaaga gcgtgaccca gaaaaccgag gcctggctgg acaacttcgc ccggtgctgg     1620

gacaacctgg tgcagaagct ggaaaagtcc accgcccaga tctcccaggc cgtgaccaca     1680

acacagccca gcctgaccca gaccaccgtg atggaaaccg tgacaacagt gaccacccgg     1740

gaacagatcc tcgtgaagca cgcccaggaa gaactgcccc ctccaccccc ccagaagaaa     1800

cggcagatca cagtggacag tgaagctcag atccacaccg tgcgggaaga gacaatgatg     1860

gtcatgacag aggacatgcc cctggaaatc agctacgtgc ccagcaccta cctgaccgag     1920

atcacccatg tgtcccaggc cctgctggaa gtggaacagc tgctgaacgc ccccgacctg     1980

tgcgccaagg atttcgagga cctgttcaag caggaagaga gcctgaagaa tatcaaggat     2040

agcctgcagc agagcagcgg ccggatcgac atcatccaca gcaagaaaac agccgccctg     2100

cagagcgcca cccccgtgga aagagtgaaa ctgcaggaag ccctgtccca gctggacttc     2160

cagtgggaga aagtgaacaa aatgtacaag gaccggcagg gcagattcga ccgcagcgtg     2220

gaaaagtggc ggcggttcca ctacgacatc aagatcttca accagtggct gacagaggcc     2280

gagcagttcc tgagaaagac ccagatcccc gagaactggg agcacgccaa gtacaagtgg     2340

tatctgaaag agctgcagga cggcatcggc cagagacaga cagtcgtgcg gaccctgaat     2400

gccaccggcg aggaaatcat ccagcagtcc agcaagaccg acgccagcat tctgcaggaa     2460

aagctgggca gcctgaacct gcggtggcag gaagtgtgca agcagctgtc cgaccggaag     2520

aagcggctgg aagaacagaa gaacatcctg caggaactgc aggaggccac cgacgagctg     2580

gacctgaaac tgagacaggc cgaagtgatc aagggcagct ggcagccagt gggcgacctg     2640

ctgatcgact ccctgcagga ccatctggaa aaagtgaagg ccctgagagg cgagatcgcc     2700

cccctgaaag aaaacgtgtc ccacgtgaac gacctggccc ggcagctgac aacactgggc     2760

attcagctga gcccctacaa cctgagcaca ctggaagatc tgaacacccg gtggaagctg     2820

ctgcaggtgg ccgtggaaga tagagtgcgg cagctgcacg aggcccacag agattttggc     2880

cctgcctccc agcacttcct gagcaccagt gtgcagggcc cttgggagag agccatctcc     2940

cctaacaagg tgccctacta catcaaccac gagacacaga ccacctgttg ggaccacccc     3000

aagatgaccg agctgtacca gagcctggct gacctgaaca acgtgcggtt cagcgcctac     3060

cggaccgcca tgaagctgcg gagactgcag aaagctctgt gcctggatct gctgtccctg     3120

tccgccgcct gtgatgccct ggaccagcac aatctgaagc agaacgacca gcccatggat     3180

atcctgcaga tcatcaactg cctgaccacc atctacgacc ggctggaaca ggaacacaac     3240

aatctcgtga acgtgcccct gtgcgtggac atgtgcctga attggctgct gaatgtgtac     3300

gacaccggcc ggacaggccg gatcagagtg ctgtccttca agaccggcat catcagcctg     3360

tgcaaagccc acctggaaga taagtaccgg tatctgttca aacaggtggc ctctagcacc     3420

ggcttttgcg accagagaag gctgggcctg ctgctgcacg acagcatcca gatccctaga     3480

cagctgggcg aagtggccag ctttggcggc agcaacatcg agcctagcgt gcggagctgc     3540

ttccagttcg ccaacaacaa gcccgagatc gaggccgccc tgttcctgga ctggatgaga     3600

ctggaacccc agagcatggt gtggctgccc gtgctgcata gagtggccgc tgccgagaca     3660

gccaagcacc aggccaagtg caacatctgc aaagagtgcc ccatcatcgg cttccggtac     3720

agaagcctga agcacttcaa ctacgatatc tgccagagct gtttcttcag cggcagggtg     3780

gccaagggcc acaaaatgca ctaccccatg gtggaatact gcacccccac cacaagcggc     3840

gaggatgtgc gggatttcgc caaggtgctg aaaaacaagt tccggaccaa gcggtacttc     3900

gccaaacacc cccggatggg ctacctgcct gtgcagacag tgctggaagg cgacaacatg     3960

gaaaccacac catgtgatga tgatttgggc agagcgatgg agtccttagt atcagtcatg     4020

acagatgaag aaggagcaga ataaatgttt tacaactcct gattcccgca tgcggccagc     4080

ttatcgatac cgtcgaaata aaagatcctt attttcattg gatctgtgtg ttggtttttt     4140

gtgtg                                                                 4145


<210>  136
<211>  4149
<212>  DNA
<213>  Homo sapiens

<400>  136
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggccc agggctacga gagaaccagc agccccaagc cccggttcaa gagctacgcc      900

tatacccagg ccgcctacgt gaccaccagc gaccctacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgagct ggctgctgag cgccgaggat     1080

acactgcagg ctcagggcga gatcagcaac gacgtggaag tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg caacatcctg     1200

cagctgggct ccaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcatct gctgaagtgg cagcggctga ccgaggaaca gtgcctgttt     1380

agcgcctggc tgtccgagaa agaggacgcc gtgaacaaga tccacaccac cggcttcaag     1440

gaccagaacg agatgctgag cagcctgcag aaactggccg tgctgaaggc cgacctggaa     1500

aagaaaaagc agtccatggg caagctgtac tccctgaagc aggacctgct gtccaccctg     1560

aagaacaaga gcgtgaccca gaaaaccgag gcctggctgg acaacttcgc ccggtgctgg     1620

gacaacctgg tgcagaagct ggaaaagtcc accgcccaga tctcccaggc cgtgaccaca     1680

acacagccca gcctgaccca gaccaccgtg atggaaaccg tgacaacagt gaccacccgg     1740

gaacagatcc tcgtgaagca cgcccaggaa gaactgcccc ctccaccccc ccagaagaaa     1800

cggcagatca cagtggacag tgaagctcag atccacaccg tgcgggaaga gacaatgatg     1860

gtcatgacag aggacatgcc cctggaaatc agctacgtgc ccagcaccta cctgaccgag     1920

atcacccatg tgtcccaggc cctgctggaa gtggaacagc tgctgaacgc ccccgacctg     1980

tgcgccaagg atttcgagga cctgttcaag caggaagaga gcctgaagaa tatcaaggat     2040

agcctgcagc agagcagcgg ccggatcgac atcatccaca gcaagaaaac agccgccctg     2100

cagagcgcca cccccgtgga aagagtgaaa ctgcaggaag ccctgtccca gctggacttc     2160

cagtgggaga aagtgaacaa aatgtacaag gaccggcagg gcagattcga ccgcagcgtg     2220

gaaaagtggc ggcggttcca ctacgacatc aagatcttca accagtggct gacagaggcc     2280

gagcagttcc tgagaaagac ccagatcccc gagaactggg agcacgccaa gtacaagtgg     2340

tatctgaaag agctgcagga cggcatcggc cagagacaga cagtcgtgcg gaccctgaat     2400

gccaccggcg aggaaatcat ccagcagtcc agcaagaccg acgccagcat tctgcaggaa     2460

aagctgggca gcctgaacct gcggtggcag gaagtgtgca agcagctgtc cgaccggaag     2520

aagcggctgg aagaacagaa gctggaacgg ctgcaggaac tgcaggaggc caccgacgag     2580

ctggacctga aactgagaca ggccgaagtg atcaagggca gctggcagcc agtgggcgac     2640

ctgctgatcg actccctgca ggaccatctg gaaaaagtga aggccctgag aggcgagatc     2700

gcccccctga aagaaaacgt gtcccacgtg aacgacctgg cccggcagct gacaacactg     2760

ggcattcagc tgagccccta caacctgagc acactggaag atctgaacac ccggtggaag     2820

ctgctgcagg tggccgtgga agatagagtg cggcagctgc acgaggccca cagagatttt     2880

ggccctgcct cccagcactt cctgagcacc agtgtgcagg gcccttggga gagagccatc     2940

tcccctaaca aggtgcccta ctacatcaac cacgagacac agaccacctg ttgggaccac     3000

cccaagatga ccgagctgta ccagagcctg gctgacctga acaacgtgcg gttcagcgcc     3060

taccggaccg ccatgaagct gcggagactg cagaaagctc tgtgcctgga tctgctgtcc     3120

ctgtccgccg cctgtgatgc cctggaccag cacaatctga agcagaacga ccagcccatg     3180

gatatcctgc agatcatcaa ctgcctgacc accatctacg accggctgga acaggaacac     3240

aacaatctcg tgaacgtgcc cctgtgcgtg gacatgtgcc tgaattggct gctgaatgtg     3300

tacgacaccg gccggacagg ccggatcaga gtgctgtcct tcaagaccgg catcatcagc     3360

ctgtgcaaag cccacctgga agataagtac cggtatctgt tcaaacaggt ggcctctagc     3420

accggctttt gcgaccagag aaggctgggc ctgctgctgc acgacagcat ccagatccct     3480

agacagctgg gcgaagtggc cagctttggc ggcagcaaca tcgagcctag cgtgcggagc     3540

tgcttccagt tcgccaacaa caagcccgag atcgaggccg ccctgttcct ggactggatg     3600

agactggaac cccagagcat ggtgtggctg cccgtgctgc atagagtggc cgctgccgag     3660

acagccaagc accaggccaa gtgcaacatc tgcaaagagt gccccatcat cggcttccgg     3720

tacagaagcc tgaagcactt caactacgat atctgccaga gctgtttctt cagcggcagg     3780

gtggccaagg gccacaaaat gcactacccc atggtggaat actgcacccc caccacaagc     3840

ggcgaggatg tgcgggattt cgccaaggtg ctgaaaaaca agttccggac caagcggtac     3900

ttcgccaaac acccccggat gggctacctg cctgtgcaga cagtgctgga aggcgacaac     3960

atggaaaccg acaccatgtg atgatgattt gggcagagcg atggagtcct tagtatcagt     4020

catgacagat gaagaaggag cagaataaat gttttacaac tcctgattcc cgcatgcggc     4080

cagcttatcg ataccgtcga aataaaagat ccttattttc attggatctg tgtgttggtt     4140

ttttgtgtg                                                             4149


<210>  137
<211>  4155
<212>  DNA
<213>  Homo sapiens

<400>  137
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggccc agggctacga gagaaccagc agccccaagc cccggttcaa gagctacgcc      900

tatacccagg ccgcctacgt gaccaccagc gaccctacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgagct ggctgctgag cgccgaggat     1080

acactgcagg ctcagggcga gatcagcaac gacgtggaag tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg caacatcctg     1200

cagctgggct ccaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcatct gctgaagtgg cagcggctga ccgaggaaca gtgcctgttt     1380

agcgcctggc tgtccgagaa agaggacgcc gtgaacaaga tccacaccac cggcttcaag     1440

gaccagaacg agatgctgag cagcctgcag aaactggccg tgctgaaggc cgacctggaa     1500

aagaaaaagc agtccatggg caagctgtac tccctgaagc aggacctgct gtccaccctg     1560

aagaacaaga gcgtgaccca gaaaaccgag gcctggctgg acaacttcgc ccggtgctgg     1620

gacaacctgg tgcagaagct ggaaaagtcc accgcccaga tctcccaggc cgtgaccaca     1680

acacagccca gcctgaccca gaccaccgtg atggaaaccg tgacaacagt gaccacccgg     1740

gaacagatcc tcgtgaagca cgcccaggaa gaactgcccc ctccaccccc ccagaagaaa     1800

cggcagatca cagtggacag tgaagctcag atccacaccg tgcgggaaga gacaatgatg     1860

gtcatgacag aggacatgcc cctggaaatc agctacgtgc ccagcaccta cctgaccgag     1920

atcacccatg tgtcccaggc cctgctggaa gtggaacagc tgctgaacgc ccccgacctg     1980

tgcgccaagg atttcgagga cctgttcaag caggaagaga gcctgaagaa tatcaaggat     2040

agcctgcagc agagcagcgg ccggatcgac atcatccaca gcaagaaaac agccgccctg     2100

cagagcgcca cccccgtgga aagagtgaaa ctgcaggaag ccctgtccca gctggacttc     2160

cagtgggaga aagtgaacaa aatgtacaag gaccggcagg gcagattcga ccgcagcgtg     2220

gaaaagtggc ggcggttcca ctacgacatc aagatcttca accagtggct gacagaggcc     2280

gagcagttcc tgagaaagac ccagatcccc gagaactggg agcacgccaa gtacaagtgg     2340

tatctgaaag agctgcagga cggcatcggc cagagacaga cagtcgtgcg gaccctgaat     2400

gccaccggcg aggaaatcat ccagcagtcc agcaagaccg acgccagcat tctgcaggaa     2460

aagctgggca gcctgaacct gcggtggcag gaagtgtgca agcagctgtc cgaccggaag     2520

aagcggctgg aagaacagaa gaacatcctg gaacggctgc aggaactgca ggaggccacc     2580

gacgagctgg acctgaaact gagacaggcc gaagtgatca agggcagctg gcagccagtg     2640

ggcgacctgc tgatcgactc cctgcaggac catctggaaa aagtgaaggc cctgagaggc     2700

gagatcgccc ccctgaaaga aaacgtgtcc cacgtgaacg acctggcccg gcagctgaca     2760

acactgggca ttcagctgag cccctacaac ctgagcacac tggaagatct gaacacccgg     2820

tggaagctgc tgcaggtggc cgtggaagat agagtgcggc agctgcacga ggcccacaga     2880

gattttggcc ctgcctccca gcacttcctg agcaccagtg tgcagggccc ttgggagaga     2940

gccatctccc ctaacaaggt gccctactac atcaaccacg agacacagac cacctgttgg     3000

gaccacccca agatgaccga gctgtaccag agcctggctg acctgaacaa cgtgcggttc     3060

agcgcctacc ggaccgccat gaagctgcgg agactgcaga aagctctgtg cctggatctg     3120

ctgtccctgt ccgccgcctg tgatgccctg gaccagcaca atctgaagca gaacgaccag     3180

cccatggata tcctgcagat catcaactgc ctgaccacca tctacgaccg gctggaacag     3240

gaacacaaca atctcgtgaa cgtgcccctg tgcgtggaca tgtgcctgaa ttggctgctg     3300

aatgtgtacg acaccggccg gacaggccgg atcagagtgc tgtccttcaa gaccggcatc     3360

atcagcctgt gcaaagccca cctggaagat aagtaccggt atctgttcaa acaggtggcc     3420

tctagcaccg gcttttgcga ccagagaagg ctgggcctgc tgctgcacga cagcatccag     3480

atccctagac agctgggcga agtggccagc tttggcggca gcaacatcga gcctagcgtg     3540

cggagctgct tccagttcgc caacaacaag cccgagatcg aggccgccct gttcctggac     3600

tggatgagac tggaacccca gagcatggtg tggctgcccg tgctgcatag agtggccgct     3660

gccgagacag ccaagcacca ggccaagtgc aacatctgca aagagtgccc catcatcggc     3720

ttccggtaca gaagcctgaa gcacttcaac tacgatatct gccagagctg tttcttcagc     3780

ggcagggtgg ccaagggcca caaaatgcac taccccatgg tggaatactg cacccccacc     3840

acaagcggcg aggatgtgcg ggatttcgcc aaggtgctga aaaacaagtt ccggaccaag     3900

cggtacttcg ccaaacaccc ccggatgggc tacctgcctg tgcagacagt gctggaaggc     3960

gacaacatgg aaaccgacac catgtgatga tgatttgggc agagcgatgg agtccttagt     4020

atcagtcatg acagatgaag aaggagcaga ataaatgttt tacaactcct gattcccgca     4080

tgcggccagc ttatcgatac cgtcgaaata aaagatcctt attttcattg gatctgtgtg     4140

ttggtttttt gtgtg                                                      4155


<210>  138
<211>  4152
<212>  DNA
<213>  Homo sapiens

<400>  138
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggccc agggctacga gagaaccagc agccccaagc cccggttcaa gagctacgcc      900

tatacccagg ccgcctacgt gaccaccagc gaccctacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgagct ggctgctgag cgccgaggat     1080

acactgcagg ctcagggcga gatcagcaac gacgtggaag tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg caacatcctg     1200

cagctgggct ccaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcatag ggtcctgctg aagtggcagc ggctgaccga ggaacagtgc     1380

ctgtttagcg cctggctgtc cgagaaagag gacgccgtga acaagatcca caccaccggc     1440

ttcaaggacc agaacgagat gctgagcagc ctgcagaaac tggccgtgct gaaggccgac     1500

ctggaaaaga aaaagcagtc catgggcaag ctgtactccc tgaagcagga cctgctgtcc     1560

accctgaaga acaagagcgt gacccagaaa accgaggcct ggctggacaa cttcgcccgg     1620

tgctgggaca acctggtgca gaagctggaa aagtccaccg cccagatctc ccaggccgtg     1680

accacaacac agcccagcct gacccagacc accgtgatgg aaaccgtgac aacagtgacc     1740

acccgggaac agatcctcgt gaagcacgcc caggaagaac tgccccctcc acccccccag     1800

aagaaacggc agatcacagt ggacagtgaa gctcagatcc acaccgtgcg ggaagagaca     1860

atgatggtca tgacagagga catgcccctg gaaatcagct acgtgcccag cacctacctg     1920

accgagatca cccatgtgtc ccaggccctg ctggaagtgg aacagctgct gaacgccccc     1980

gacctgtgcg ccaaggattt cgaggacctg ttcaagcagg aagagagcct gaagaatatc     2040

aaggatagcc tgcagcagag cagcggccgg atcgacatca tccacagcaa gaaaacagcc     2100

gccctgcaga gcgccacccc cgtggaaaga gtgaaactgc aggaagccct gtcccagctg     2160

gacttccagt gggagaaagt gaacaaaatg tacaaggacc ggcagggcag attcgaccgc     2220

agcgtggaaa agtggcggcg gttccactac gacatcaaga tcttcaacca gtggctgaca     2280

gaggccgagc agttcctgag aaagacccag atccccgaga actgggagca cgccaagtac     2340

aagtggtatc tgaaagagct gcaggacggc atcggccaga gacagacagt cgtgcggacc     2400

ctgaatgcca ccggcgagga aatcatccag cagtccagca agaccgacgc cagcattctg     2460

caggaaaagc tgggcagcct gaacctgcgg tggcaggaag tgtgcaagca gctgtccgac     2520

cggaagaagc ggctggaaga acagctggaa cggctgcagg aactgcagga ggccaccgac     2580

gagctggacc tgaaactgag acaggccgaa gtgatcaagg gcagctggca gccagtgggc     2640

gacctgctga tcgactccct gcaggaccat ctggaaaaag tgaaggccct gagaggcgag     2700

atcgcccccc tgaaagaaaa cgtgtcccac gtgaacgacc tggcccggca gctgacaaca     2760

ctgggcattc agctgagccc ctacaacctg agcacactgg aagatctgaa cacccggtgg     2820

aagctgctgc aggtggccgt ggaagataga gtgcggcagc tgcacgaggc ccacagagat     2880

tttggccctg cctcccagca cttcctgagc accagtgtgc agggcccttg ggagagagcc     2940

atctccccta acaaggtgcc ctactacatc aaccacgaga cacagaccac ctgttgggac     3000

caccccaaga tgaccgagct gtaccagagc ctggctgacc tgaacaacgt gcggttcagc     3060

gcctaccgga ccgccatgaa gctgcggaga ctgcagaaag ctctgtgcct ggatctgctg     3120

tccctgtccg ccgcctgtga tgccctggac cagcacaatc tgaagcagaa cgaccagccc     3180

atggatatcc tgcagatcat caactgcctg accaccatct acgaccggct ggaacaggaa     3240

cacaacaatc tcgtgaacgt gcccctgtgc gtggacatgt gcctgaattg gctgctgaat     3300

gtgtacgaca ccggccggac aggccggatc agagtgctgt ccttcaagac cggcatcatc     3360

agcctgtgca aagcccacct ggaagataag taccggtatc tgttcaaaca ggtggcctct     3420

agcaccggct tttgcgacca gagaaggctg ggcctgctgc tgcacgacag catccagatc     3480

cctagacagc tgggcgaagt ggccagcttt ggcggcagca acatcgagcc tagcgtgcgg     3540

agctgcttcc agttcgccaa caacaagccc gagatcgagg ccgccctgtt cctggactgg     3600

atgagactgg aaccccagag catggtgtgg ctgcccgtgc tgcatagagt ggccgctgcc     3660

gagacagcca agcaccaggc caagtgcaac atctgcaaag agtgccccat catcggcttc     3720

cggtacagaa gcctgaagca cttcaactac gatatctgcc agagctgttt cttcagcggc     3780

agggtggcca agggccacaa aatgcactac cccatggtgg aatactgcac ccccaccaca     3840

agcggcgagg atgtgcggga tttcgccaag gtgctgaaaa acaagttccg gaccaagcgg     3900

tacttcgcca aacacccccg gatgggctac ctgcctgtgc agacagtgct ggaaggcgac     3960

aacatggaaa ccgacaccat gtgatgatga tttgggcaga gcgatggagt ccttagtatc     4020

agtcatgaca gatgaagaag gagcagaata aatgttttac aactcctgat tcccgcatgc     4080

ggccagctta tcgataccgt cgaaataaaa gatccttatt ttcattggat ctgtgtgttg     4140

gttttttgtg tg                                                         4152


<210>  139
<211>  4167
<212>  DNA
<213>  Homo sapiens

<400>  139
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggccc agggctacga gagaaccagc agccccaagc cccggttcaa gagctacgcc      900

tatacccagg ccgcctacgt gaccaccagc gaccctacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgagct ggctgctgag cgccgaggat     1080

acactgcagg ctcagggcga gatcagcaac gacgtggaag tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg caacatcctg     1200

cagctgggct ccaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcatag agtactgctc caagacatcc tgctgaagtg gcagcggctg     1380

accgaggaac agtgcctgtt tagcgcctgg ctgtccgaga aagaggacgc cgtgaacaag     1440

atccacacca ccggcttcaa ggaccagaac gagatgctga gcagcctgca gaaactggcc     1500

gtgctgaagg ccgacctgga aaagaaaaag cagtccatgg gcaagctgta ctccctgaag     1560

caggacctgc tgtccaccct gaagaacaag agcgtgaccc agaaaaccga ggcctggctg     1620

gacaacttcg cccggtgctg ggacaacctg gtgcagaagc tggaaaagtc caccgcccag     1680

atctcccagg ccgtgaccac aacacagccc agcctgaccc agaccaccgt gatggaaacc     1740

gtgacaacag tgaccacccg ggaacagatc ctcgtgaagc acgcccagga agaactgccc     1800

cctccacccc cccagaagaa acggcagatc acagtggaca gtgaagctca gatccacacc     1860

gtgcgggaag agacaatgat ggtcatgaca gaggacatgc ccctggaaat cagctacgtg     1920

cccagcacct acctgaccga gatcacccat gtgtcccagg ccctgctgga agtggaacag     1980

ctgctgaacg cccccgacct gtgcgccaag gatttcgagg acctgttcaa gcaggaagag     2040

agcctgaaga atatcaagga tagcctgcag cagagcagcg gccggatcga catcatccac     2100

agcaagaaaa cagccgccct gcagagcgcc acccccgtgg aaagagtgaa actgcaggaa     2160

gccctgtccc agctggactt ccagtgggag aaagtgaaca aaatgtacaa ggaccggcag     2220

ggcagattcg accgcagcgt ggaaaagtgg cggcggttcc actacgacat caagatcttc     2280

aaccagtggc tgacagaggc cgagcagttc ctgagaaaga cccagatccc cgagaactgg     2340

gagcacgcca agtacaagtg gtatctgaaa gagctgcagg acggcatcgg ccagagacag     2400

acagtcgtgc ggaccctgaa tgccaccggc gaggaaatca tccagcagtc cagcaagacc     2460

gacgccagca ttctgcagga aaagctgggc agcctgaacc tgcggtggca ggaagtgtgc     2520

aagcagctgt ccgaccggaa gaagcggctg gaagaacagc tggaacggct gcaggaactg     2580

caggaggcca ccgacgagct ggacctgaaa ctgagacagg ccgaagtgat caagggcagc     2640

tggcagccag tgggcgacct gctgatcgac tccctgcagg accatctgga aaaagtgaag     2700

gccctgagag gcgagatcgc ccccctgaaa gaaaacgtgt cccacgtgaa cgacctggcc     2760

cggcagctga caacactggg cattcagctg agcccctaca acctgagcac actggaagat     2820

ctgaacaccc ggtggaagct gctgcaggtg gccgtggaag atagagtgcg gcagctgcac     2880

gaggcccaca gagattttgg ccctgcctcc cagcacttcc tgagcaccag tgtgcagggc     2940

ccttgggaga gagccatctc ccctaacaag gtgccctact acatcaacca cgagacacag     3000

accacctgtt gggaccaccc caagatgacc gagctgtacc agagcctggc tgacctgaac     3060

aacgtgcggt tcagcgccta ccggaccgcc atgaagctgc ggagactgca gaaagctctg     3120

tgcctggatc tgctgtccct gtccgccgcc tgtgatgccc tggaccagca caatctgaag     3180

cagaacgacc agcccatgga tatcctgcag atcatcaact gcctgaccac catctacgac     3240

cggctggaac aggaacacaa caatctcgtg aacgtgcccc tgtgcgtgga catgtgcctg     3300

aattggctgc tgaatgtgta cgacaccggc cggacaggcc ggatcagagt gctgtccttc     3360

aagaccggca tcatcagcct gtgcaaagcc cacctggaag ataagtaccg gtatctgttc     3420

aaacaggtgg cctctagcac cggcttttgc gaccagagaa ggctgggcct gctgctgcac     3480

gacagcatcc agatccctag acagctgggc gaagtggcca gctttggcgg cagcaacatc     3540

gagcctagcg tgcggagctg cttccagttc gccaacaaca agcccgagat cgaggccgcc     3600

ctgttcctgg actggatgag actggaaccc cagagcatgg tgtggctgcc cgtgctgcat     3660

agagtggccg ctgccgagac agccaagcac caggccaagt gcaacatctg caaagagtgc     3720

cccatcatcg gcttccggta cagaagcctg aagcacttca actacgatat ctgccagagc     3780

tgtttcttca gcggcagggt ggccaagggc cacaaaatgc actaccccat ggtggaatac     3840

tgcaccccca ccacaagcgg cgaggatgtg cgggatttcg ccaaggtgct gaaaaacaag     3900

ttccggacca agcggtactt cgccaaacac ccccggatgg gctacctgcc tgtgcagaca     3960

gtgctggaag gcgacaacat ggaaaccgac accatgtgat gatgatttgg gcagagcgat     4020

ggagtcctta gtatcagtca tgacagatga agaaggagca gaataaatgt tttacaactc     4080

ctgattcccg catgcggcca gcttatcgat accgtcgaaa taaaagatcc ttattttcat     4140

tggatctgtg tgttggtttt ttgtgtg                                         4167


<210>  140
<211>  4146
<212>  DNA
<213>  Homo sapiens

<400>  140
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggccc agggctacga gagaaccagc agccccaagc cccggttcaa gagctacgcc      900

tatacccagg ccgcctacgt gaccaccagc gaccctacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgagct ggctgctgag cgccgaggat     1080

acactgcagg ctcagggcga gatcagcaac gacgtggaag tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg caacatcctg     1200

cagctgggct ccaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcatct gctgaagtgg cagcggctga ccgaggaaca gtgcctgttt     1380

agcgcctggc tgtccgagaa agaggacgcc gtgaacaaga tccacaccac cggcttcaag     1440

gaccagaacg agatgctgag cagcctgcag aaactggccg tgctgaaggc cgacctggaa     1500

aagaaaaagc agtccatggg caagctgtac tccctgaagc aggacctgct gtccaccctg     1560

aagaacaaga gcgtgaccca gaaaaccgag gcctggctgg acaacttcgc ccggtgctgg     1620

gacaacctgg tgcagaagct ggaaaagtcc accgcccaga tctcccaggc cgtgaccaca     1680

acacagccca gcctgaccca gaccaccgtg atggaaaccg tgacaacagt gaccacccgg     1740

gaacagatcc tcgtgaagca cgcccaggaa gaactgcccc ctccaccccc ccagaagaaa     1800

cggcagatca cagtggacag tgaagctcag atccacaccg tgcgggaaga gacaatgatg     1860

gtcatgacag aggacatgcc cctggaaatc agctacgtgc ccagcaccta cctgaccgag     1920

atcacccatg tgtcccaggc cctgctggaa gtggaacagc tgctgaacgc ccccgacctg     1980

tgcgccaagg atttcgagga cctgttcaag caggaagaga gcctgaagaa tatcaaggat     2040

agcctgcagc agagcagcgg ccggatcgac atcatccaca gcaagaaaac agccgccctg     2100

cagagcgcca cccccgtgga aagagtgaaa ctgcaggaag ccctgtccca gctggacttc     2160

cagtgggaga aagtgaacaa aatgtacaag gaccggcagg gcagattcga ccgcagcgtg     2220

gaaaagtggc ggcggttcca ctacgacatc aagatcttca accagtggct gacagaggcc     2280

gagcagttcc tgagaaagac ccagatcccc gagaactggg agcacgccaa gtacaagtgg     2340

tatctgaaag agctgcagga cggcatcggc cagagacaga cagtcgtgcg gaccctgaat     2400

gccaccggcg aggaaatcat ccagcagtcc agcaagaccg acgccagcat tctgcaggaa     2460

aagctgggca gcctgaacct gcggtggcag gaagtgtgca agcagctgtc cgaccggaag     2520

aagcggctgg aagaacagct ggaacggctg caggaactgc aggaggccac cgacgagctg     2580

gacctgaaac tgagacaggc cgaagtgatc aagggcagct ggcagccagt gggcgacctg     2640

ctgatcgact ccctgcagga ccatctggaa aaagtgaagg ccctgagagg cgagatcgcc     2700

cccctgaaag aaaacgtgtc ccacgtgaac gacctggccc ggcagctgac aacactgggc     2760

attcagctga gcccctacaa cctgagcaca ctggaagatc tgaacacccg gtggaagctg     2820

ctgcaggtgg ccgtggaaga tagagtgcgg cagctgcacg aggcccacag agattttggc     2880

cctgcctccc agcacttcct gagcaccagt gtgcagggcc cttgggagag agccatctcc     2940

cctaacaagg tgccctacta catcaaccac gagacacaga ccacctgttg ggaccacccc     3000

aagatgaccg agctgtacca gagcctggct gacctgaaca acgtgcggtt cagcgcctac     3060

cggaccgcca tgaagctgcg gagactgcag aaagctctgt gcctggatct gctgtccctg     3120

tccgccgcct gtgatgccct ggaccagcac aatctgaagc agaacgacca gcccatggat     3180

atcctgcaga tcatcaactg cctgaccacc atctacgacc ggctggaaca ggaacacaac     3240

aatctcgtga acgtgcccct gtgcgtggac atgtgcctga attggctgct gaatgtgtac     3300

gacaccggcc ggacaggccg gatcagagtg ctgtccttca agaccggcat catcagcctg     3360

tgcaaagccc acctggaaga taagtaccgg tatctgttca aacaggtggc ctctagcacc     3420

ggcttttgcg accagagaag gctgggcctg ctgctgcacg acagcatcca gatccctaga     3480

cagctgggcg aagtggccag ctttggcggc agcaacatcg agcctagcgt gcggagctgc     3540

ttccagttcg ccaacaacaa gcccgagatc gaggccgccc tgttcctgga ctggatgaga     3600

ctggaacccc agagcatggt gtggctgccc gtgctgcata gagtggccgc tgccgagaca     3660

gccaagcacc aggccaagtg caacatctgc aaagagtgcc ccatcatcgg cttccggtac     3720

agaagcctga agcacttcaa ctacgatatc tgccagagct gtttcttcag cggcagggtg     3780

gccaagggcc acaaaatgca ctaccccatg gtggaatact gcacccccac cacaagcggc     3840

gaggatgtgc gggatttcgc caaggtgctg aaaaacaagt tccggaccaa gcggtacttc     3900

gccaaacacc cccggatggg ctacctgcct gtgcagacag tgctggaagg cgacaacatg     3960

gaaaccgaca ccatgtgatg atgatttggg cagagcgatg gagtccttag tatcagtcat     4020

gacagatgaa gaaggagcag aataaatgtt ttacaactcc tgattcccgc atgcggccag     4080

cttatcgata ccgtcgaaat aaaagatcct tattttcatt ggatctgtgt gttggttttt     4140

tgtgtg                                                                4146


<210>  141
<211>  3936
<212>  DNA
<213>  Homo sapiens

<400>  141
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggctc agggctacga gcggaccagc agccccaagc cccggttcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccaccagc gaccccacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgtcct ggctgctgag cgccgaggat     1080

acactgcagg cccagggcga gatcagcaac gacgtggaag tggtgaaaga ccagttccac     1140

acccacgagg gctacatgat ggacctgacc gcccaccagg gcagagtggg caacatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcacat ccacaccgtg cgggaagaga caatgatggt gatgaccgag     1380

gacatgcccc tggaaatcag ctacgtgccc agcacctacc tgaccgagat cacccacgtg     1440

tcccaggctc tgctggaagt ggaacagctg ctgaacgccc ccgacctgtg cgccaaggac     1500

ttcgaggatc tgttcaagca ggaagagagc ctgaagaata tcaaggactc cctgcagcag     1560

tccagcggcc ggatcgacat catccacagc aagaaaacag ccgccctgca gtccgccacc     1620

cccgtggaaa gagtgaagct gcaggaagcc ctgagccagc tggacttcca gtgggagaaa     1680

gtgaacaaga tgtacaagga ccggcagggc agattcgacc gcagcgtgga aaagtggcgg     1740

cggttccact acgacatcaa gatcttcaac cagtggctga ccgaggccga gcagttcctg     1800

agaaagaccc agatccccga gaactgggag cacgccaagt acaagtggta tctgaaagaa     1860

ctgcaggatg gcatcggcca gcggcagacc gtggtgcgca cactgaatgc caccggcgag     1920

gaaatcatcc agcagagcag caagaccgac gccagcatcc tgcaggaaaa gctgggctcc     1980

ctgaacctgc ggtggcagga agtgtgcaag cagctgagcg accggaagaa gaggctggaa     2040

gaacaggccc ctggcctgac caccatcggc gccagcccta cccagaccgt gaccctggtg     2100

acacagcccg tggtgacaaa agagacagcc atctccaagc tggaaatgcc cagctccctg     2160

atgctggaac tggaaaggct gcaggaactg caggaggcca ccgacgagct ggacctgaag     2220

ctgcggcagg ccgaagtgat caagggcagc tggcagcccg tgggcgacct gctgatcgac     2280

agcctgcagg accacctgga aaaagtgaag gccctgagag gcgagatcgc ccccctgaaa     2340

gaaaacgtgt cccacgtgaa cgacctggcc cggcagctga ccaccctggg catccagctg     2400

agcccctaca acctgagcac cctggaagat ctgaacaccc ggtggaagct gctgcaggtg     2460

gccgtggaag atagagtgcg gcagctgcac gaggcccaca gagactttgg ccctgccagc     2520

cagcacttcc tgagcacctc tgtgcaggga ccctgggaga gagccatcag ccccaacaag     2580

gtgccctact acatcaacca cgagacacag accacctgtt gggaccaccc caagatgacc     2640

gagctgtacc agagcctggc cgacctgaac aatgtgcggt tcagcgccta ccggaccgcc     2700

atgaagctga ggcggctgca gaaagctctg tgcctggatc tgctgagcct gagcgccgcc     2760

tgcgacgccc tggaccagca caacctgaag cagaacgacc agcccatgga tatcctgcag     2820

atcatcaact gcctgaccac aatctacgac aggctggaac aggaacacaa caatctggtc     2880

aacgtgcccc tgtgcgtgga catgtgcctg aattggctgc tgaatgtgta cgacaccggc     2940

cggaccggca gaatccgggt gctgagcttc aagaccggca tcatcagcct gtgcaaggcc     3000

cacctggaag ataagtaccg ctacctgttc aaacaggtgg ccagctccac cggcttttgc     3060

gaccagcgga gactgggcct gctgctgcac gacagcatcc agatccccag acagctgggc     3120

gaggtggcct ccttcggcgg cagcaacatt gagcccagcg tgcggagctg cttccagttc     3180

gccaacaaca agcccgagat cgaggccgcc ctgttcctgg actggatgag actggaaccc     3240

cagagcatgg tgtggctgcc cgtgctgcat cgggtggccg ctgccgagac agccaagcac     3300

caggccaagt gcaacatctg caaagagtgc cccatcatcg gcttccggta cagaagcctg     3360

aagcacttca actacgatat ctgccagagc tgcttcttca gcggcagagt ggccaagggc     3420

cacaaaatgc actaccccat ggtggaatac tgcaccccca ccaccagcgg cgaggatgtg     3480

cgggacttcg ccaaggtgct gaaaaacaag ttccggacca agcggtactt tgccaagcac     3540

ccccggatgg gctacctgcc cgtgcagaca gtgctggaag gcgacaacat ggaaacccct     3600

gcccagatcc tgatcagcct ggaaagcgag gaacggggcg agctggaacg gatcctggcc     3660

gatctggaag aggaaaaccg gaacctgcag gccgagtacg accggctgaa gcagcagcac     3720

gagcacaagg gcctgagccc cctgcctagc ccccctgaca ccatgtgatg atgatttggg     3780

cagagcgatg gagtccttag tatcagtcat gacagatgaa gaaggagcag aataaatgtt     3840

ttacaactcc tgattcccgc atgcggccag cttatcgata ccgtcgaaat aaaagatcct     3900

tattttcatt ggatctgtgt gttggttttt tgtgtg                               3936


<210>  142
<211>  3957
<212>  DNA
<213>  Homo sapiens

<400>  142
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggctc agggctacga gcggaccagc agccccaagc cccggttcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccaccagc gaccccacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgtcct ggctgctgag cgccgaggat     1080

acactgcagg cccagggcga gatcagcaac gacgtggaag tggtgaaaga ccagttccac     1140

acccacgagg gctacatgat ggacctgacc gcccaccagg gcagagtggg caacatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcaccg ggtgctgatc cacaccgtgc gggaagagac aatgatggtg     1380

atgaccgagg acatgcccct ggaaatcagc tacgtgccca gcacctacct gaccgagatc     1440

acccacgtgt cccaggctct gctggaagtg gaacagctgc tgaacgcccc cgacctgtgc     1500

gccaaggact tcgaggatct gttcaagcag gaagagagcc tgaagaatat caaggactcc     1560

ctgcagcagt ccagcggccg gatcgacatc atccacagca agaaaacagc cgccctgcag     1620

tccgccaccc ccgtggaaag agtgaagctg caggaagccc tgagccagct ggacttccag     1680

tgggagaaag tgaacaagat gtacaaggac cggcagggca gattcgaccg cagcgtggaa     1740

aagtggcggc ggttccacta cgacatcaag atcttcaacc agtggctgac cgaggccgag     1800

cagttcctga gaaagaccca gatccccgag aactgggagc acgccaagta caagtggtat     1860

ctgaaagaac tgcaggatgg catcggccag cggcagaccg tggtgcgcac actgaatgcc     1920

accggcgagg aaatcatcca gcagagcagc aagaccgacg ccagcatcct gcaggaaaag     1980

ctgggctccc tgaacctgcg gtggcaggaa gtgtgcaagc agctgagcga ccggaagaag     2040

aggctggaag aacagaagaa cgacctggcc cctggcctga ccaccatcgg cgccagccct     2100

acccagaccg tgaccctggt gacacagccc gtggtgacaa aagagacagc catctccaag     2160

ctggaaatgc ccagctccct gatgctggaa gtggaaaggc tgcaggaact gcaggaggcc     2220

accgacgagc tggacctgaa gctgcggcag gccgaagtga tcaagggcag ctggcagccc     2280

gtgggcgacc tgctgatcga cagcctgcag gaccacctgg aaaaagtgaa ggccctgaga     2340

ggcgagatcg cccccctgaa agaaaacgtg tcccacgtga acgacctggc ccggcagctg     2400

accaccctgg gcatccagct gagcccctac aacctgagca ccctggaaga tctgaacacc     2460

cggtggaagc tgctgcaggt ggccgtggaa gatagagtgc ggcagctgca cgaggcccac     2520

agagactttg gccctgccag ccagcacttc ctgagcacct ctgtgcaggg accctgggag     2580

agagccatca gccccaacaa ggtgccctac tacatcaacc acgagacaca gaccacctgt     2640

tgggaccacc ccaagatgac cgagctgtac cagagcctgg ccgacctgaa caatgtgcgg     2700

ttcagcgcct accggaccgc catgaagctg aggcggctgc agaaagctct gtgcctggat     2760

ctgctgagcc tgagcgccgc ctgcgacgcc ctggaccagc acaacctgaa gcagaacgac     2820

cagcccatgg atatcctgca gatcatcaac tgcctgacca caatctacga caggctggaa     2880

caggaacaca acaatctggt caacgtgccc ctgtgcgtgg acatgtgcct gaattggctg     2940

ctgaatgtgt acgacaccgg ccggaccggc agaatccggg tgctgagctt caagaccggc     3000

atcatcagcc tgtgcaaggc ccacctggaa gataagtacc gctacctgtt caaacaggtg     3060

gccagctcca ccggcttttg cgaccagcgg agactgggcc tgctgctgca cgacagcatc     3120

cagatcccca gacagctggg cgaggtggcc tccttcggcg gcagcaacat tgagcccagc     3180

gtgcggagct gcttccagtt cgccaacaac aagcccgaga tcgaggccgc cctgttcctg     3240

gactggatga gactggaacc ccagagcatg gtgtggctgc ccgtgctgca tcgggtggcc     3300

gctgccgaga cagccaagca ccaggccaag tgcaacatct gcaaagagtg ccccatcatc     3360

ggcttccggt acagaagcct gaagcacttc aactacgata tctgccagag ctgcttcttc     3420

agcggcagag tggccaaggg ccacaaaatg cactacccca tggtggaata ctgcaccccc     3480

accaccagcg gcgaggatgt gcgggacttc gccaaggtgc tgaaaaacaa gttccggacc     3540

aagcggtact ttgccaagca cccccggatg ggctacctgc ccgtgcagac agtgctggaa     3600

ggcgacaaca tggaaacccc tgcccagatc ctgatcagcc tggaaagcga ggaacggggc     3660

gagctggaac ggatcctggc cgatctggaa gaggaaaacc ggaacctgca ggccgagtac     3720

gaccggctga agcagcagca cgagcacaag ggcctgagcc ccctgcctag cccccctgac     3780

accatgtgat gatgatttgg gcagagcgat ggagtcctta gtatcagtca tgacagatga     3840

agaaggagca gaataaatgt tttacaactc ctgattcccg catgcggcca gcttatcgat     3900

accgtcgaaa taaaagatcc ttattttcat tggatctgtg tgttggtttt ttgtgtg        3957


<210>  143
<211>  3918
<212>  DNA
<213>  Homo sapiens

<400>  143
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggctc agggctacga gcggaccagc agccccaagc cccggttcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccaccagc gaccccacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgtcct ggctgctgag cgccgaggat     1080

acactgcagg cccagggcga gatcagcaac gacgtggaag tggtgaaaga ccagttccac     1140

acccacgagg gctacatgat ggacctgacc gcccaccagg gcagagtggg caacatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcacag ctacgtgccc agcacctacc tgaccgagat cacccacgtg     1380

tcccaggctc tgctggaagt ggaacagctg ctgaacgccc ccgacctgtg cgccaaggac     1440

ttcgaggatc tgttcaagca ggaagagagc ctgaagaata tcaaggactc cctgcagcag     1500

tccagcggcc ggatcgacat catccacagc aagaaaacag ccgccctgca gtccgccacc     1560

cccgtggaaa gagtgaagct gcaggaagcc ctgagccagc tggacttcca gtgggagaaa     1620

gtgaacaaga tgtacaagga ccggcagggc agattcgacc gcagcgtgga aaagtggcgg     1680

cggttccact acgacatcaa gatcttcaac cagtggctga ccgaggccga gcagttcctg     1740

agaaagaccc agatccccga gaactgggag cacgccaagt acaagtggta tctgaaagaa     1800

ctgcaggatg gcatcggcca gcggcagacc gtggtgcgca cactgaatgc caccggcgag     1860

gaaatcatcc agcagagcag caagaccgac gccagcatcc tgcaggaaaa gctgggctcc     1920

ctgaacctgc ggtggcagga agtgtgcaag cagctgagcg accggaagaa gaggctggaa     1980

gaacagctgg aaggactgga aaagctgtac caggaaccca gagagctgcc ccccgaggaa     2040

cgggcccaga acgtgacccg gctgctgcgg aaacaggccg aagaggtgaa caccgagtgg     2100

gagaagctga acctgcactc cgccgactgg cagcggaaga tcgacgagac actggaaagg     2160

ctgcaggaac tgcaggaggc caccgacgag ctggacctga agctgcggca ggccgaagtg     2220

atcaagggca gctggcagcc cgtgggcgac ctgctgatcg acagcctgca ggaccacctg     2280

gaaaaagtga aggccctgag aggcgagatc gcccccctga aagaaaacgt gtcccacgtg     2340

aacgacctgg cccggcagct gaccaccctg ggcatccagc tgagccccta caacctgagc     2400

accctggaag atctgaacac ccggtggaag ctgctgcagg tggccgtgga agatagagtg     2460

cggcagctgc acgaggccca cagagacttt ggccctgcca gccagcactt cctgagcacc     2520

tctgtgcagg gaccctggga gagagccatc agccccaaca aggtgcccta ctacatcaac     2580

cacgagacac agaccacctg ttgggaccac cccaagatga ccgagctgta ccagagcctg     2640

gccgacctga acaatgtgcg gttcagcgcc taccggaccg ccatgaagct gaggcggctg     2700

cagaaagctc tgtgcctgga tctgctgagc ctgagcgccg cctgcgacgc cctggaccag     2760

cacaacctga agcagaacga ccagcccatg gatatcctgc agatcatcaa ctgcctgacc     2820

acaatctacg acaggctgga acaggaacac aacaatctgg tcaacgtgcc cctgtgcgtg     2880

gacatgtgcc tgaattggct gctgaatgtg tacgacaccg gccggaccgg cagaatccgg     2940

gtgctgagct tcaagaccgg catcatcagc ctgtgcaagg cccacctgga agataagtac     3000

cgctacctgt tcaaacaggt ggccagctcc accggctttt gcgaccagcg gagactgggc     3060

ctgctgctgc acgacagcat ccagatcccc agacagctgg gcgaggtggc ctccttcggc     3120

ggcagcaaca ttgagcccag cgtgcggagc tgcttccagt tcgccaacaa caagcccgag     3180

atcgaggccg ccctgttcct ggactggatg agactggaac cccagagcat ggtgtggctg     3240

cccgtgctgc atcgggtggc cgctgccgag acagccaagc accaggccaa gtgcaacatc     3300

tgcaaagagt gccccatcat cggcttccgg tacagaagcc tgaagcactt caactacgat     3360

atctgccaga gctgcttctt cagcggcaga gtggccaagg gccacaaaat gcactacccc     3420

atggtggaat actgcacccc caccaccagc ggcgaggatg tgcgggactt cgccaaggtg     3480

ctgaaaaaca agttccggac caagcggtac tttgccaagc acccccggat gggctacctg     3540

cccgtgcaga cagtgctgga aggcgacaac atggaaaccc ctgcccagat cctgatcagc     3600

ctggaaagcg aggaacgggg cgagctggaa cggatcctgg ccgatctgga agaggaaaac     3660

cggaacctgc aggccgagta cgaccggctg aagcagcagc acgagcacaa gggcctgagc     3720

cccctgccta gcccccctga caccatgtga tgatgatttg ggcagagcga tggagtcctt     3780

agtatcagtc atgacagatg aagaaggagc agaataaatg ttttacaact cctgattccc     3840

gcatgcggcc agcttatcga taccgtcgaa ataaaagatc cttattttca ttggatctgt     3900

gtgttggttt tttgtgtg                                                   3918


<210>  144
<211>  4244
<212>  DNA
<213>  Homo sapiens

<400>  144
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggccc agggctacga gagaaccagc agccccaagc cccggttcaa gagctacgcc      900

tatacccagg ccgcctacgt gaccaccagc gaccctacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgagct ggctgctgag cgccgaggat     1080

acactgcagg ctcagggcga gatcagcaac gacgtggaag tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg caacatcctg     1200

cagctgggct ccaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcatct gctgaagtgg cagcggctga ccgaggaaca gtgcctgttt     1380

agcgcctggc tgtccgagaa agaggacgcc gtgaacaaga tccacaccac cggcttcaag     1440

gaccagaacg agatgctgag cagcctgcag aaactggccg tgctgaaggc cgacctggaa     1500

aagaaaaagc agtccatggg caagctgtac tccctgaagc aggacctgct gtccaccctg     1560

aagaacaaga gcgtgaccca gaaaaccgag gcctggctgg acaacttcgc ccggtgctgg     1620

gacaacctgg tgcagaagct ggaaaagtcc accgcccaga tctcccaggc cgtgaccaca     1680

acacagccca gcctgaccca gaccaccgtg atggaaaccg tgacaacagt gaccacccgg     1740

gaacagatcc tcgtgaagca cgcccaggaa gaactgcccc ctccaccccc ccagaagaaa     1800

cggcagatca cagtggacat ccacaccgtg cgggaagaga caatgatggt catgacagag     1860

gacatgcccc tggaaatcag ctacgtgccc agcacctacc tgaccgagat cacccatgtg     1920

tcccaggccc tgctggaagt ggaacagctg ctgaacgccc ccgacctgtg cgccaaggat     1980

ttcgaggacc tgttcaagca ggaagagagc ctgaagaata tcaaggatag cctgcagcag     2040

agcagcggcc ggatcgacat catccacagc aagaaaacag ccgccctgca gagcgccacc     2100

cccgtggaaa gagtgaaact gcaggaagcc ctgtcccagc tggacttcca gtgggagaaa     2160

gtgaacaaaa tgtacaagga ccggcagggc agattcgacc gcagcgtgga aaagtggcgg     2220

cggttccact acgacatcaa gatcttcaac cagtggctga cagaggccga gcagttcctg     2280

agaaagaccc agatccccga gaactgggag cacgccaagt acaagtggta tctgaaagag     2340

ctgcaggacg gcatcggcca gagacagaca gtcgtgcgga ccctgaatgc caccggcgag     2400

gaaatcatcc agcagtccag caagaccgac gccagcattc tgcaggaaaa gctgggcagc     2460

ctgaacctgc ggtggcagga agtgtgcaag cagctgtccg accggaagaa gcggctggaa     2520

gaacagctgg aacggctgca ggaactgcag gaggccaccg acgagctgga cctgaaactg     2580

agacaggccg aagtgatcaa gggcagctgg cagccagtgg gcgacctgct gatcgactcc     2640

ctgcaggacc atctggaaaa agtgaaggcc ctgagaggcg agatcgcccc cctgaaagaa     2700

aacgtgtccc acgtgaacga cctggcccgg cagctgacaa cactgggcat tcagctgagc     2760

ccctacaacc tgagcacact ggaagatctg aacacccggt ggaagctgct gcaggtggcc     2820

gtggaagata gagtgcggca gctgcacgag gcccacagag attttggccc tgcctcccag     2880

cacttcctga gcaccagtgt gcagggccct tgggagagag ccatctcccc taacaaggtg     2940

ccctactaca tcaaccacga gacacagacc acctgttggg accaccccaa gatgaccgag     3000

ctgtaccaga gcctggctga cctgaacaac gtgcggttca gcgcctaccg gaccgccatg     3060

aagctgcgga gactgcagaa agctctgtgc ctggatctgc tgtccctgtc cgccgcctgt     3120

gatgccctgg accagcacaa tctgaagcag aacgaccagc ccatggatat cctgcagatc     3180

atcaactgcc tgaccaccat ctacgaccgg ctggaacagg aacacaacaa tctcgtgaac     3240

gtgcccctgt gcgtggacat gtgcctgaat tggctgctga atgtgtacga caccggccgg     3300

acaggccgga tcagagtgct gtccttcaag accggcatca tcagcctgtg caaagcccac     3360

ctggaagata agtaccggta tctgttcaaa caggtggcct ctagcaccgg cttttgcgac     3420

cagagaaggc tgggcctgct gctgcacgac agcatccaga tccctagaca gctgggcgaa     3480

gtggccagct ttggcggcag caacatcgag cctagcgtgc ggagctgctt ccagttcgcc     3540

aacaacaagc ccgagatcga ggccgccctg ttcctggact ggatgagact ggaaccccag     3600

agcatggtgt ggctgcccgt gctgcataga gtggccgctg ccgagacagc caagcaccag     3660

gccaagtgca acatctgcaa agagtgcccc atcatcggct tccggtacag aagcctgaag     3720

cacttcaact acgatatctg ccagagctgt ttcttcagcg gcagggtggc caagggccac     3780

aaaatgcact accccatggt ggaatactgc acccccacca caagcggcga ggatgtgcgg     3840

gatttcgcca aggtgctgaa aaacaagttc cggaccaagc ggtacttcgc caaacacccc     3900

cggatgggct acctgcctgt gcagacagtg ctggaaggcg acaacatgga aacccctgcc     3960

cagatcctga tcagcctgga atccgaggaa cggggcgagc tggaacggat cctggccgat     4020

ctggaagagg aaaaccggaa cctgcaggcc gagtacgacc ggctgaagca gcagcacgag     4080

cacaagggcc tgagccccct gcctagcccc cctgacacca tgtgatgatg atttgggcag     4140

agcgatggag tccttagtat cagtcatgac agatgaagaa ggagcagaat aaatgtttta     4200

caactcctga ttcccgcatg cggccagctt atcgataccg tcga                      4244


<210>  145
<211>  4266
<212>  DNA
<213>  Homo sapiens

<400>  145
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggctc agggctacga gcggaccagc agccccaagc cccggttcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccaccagc gaccccacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgtcct ggctgctgag cgccgaggat     1080

acactgcagg cccagggcga gatcagcaac gacgtggaag tggtgaaaga ccagttccac     1140

acccacgagg gctacatgat ggacctgacc gcccaccagg gcagagtggg caacatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcacat ccacaccgtg cgggaagaga caatgatggt gatgaccgag     1380

gacatgcccc tggaaatcag ctacgtgccc agcacctacc tgaccgagat cacccacgtg     1440

tcccaggctc tgctggaagt ggaacagctg ctgaacgccc ccgacctgtg cgccaaggac     1500

ttcgaggatc tgttcaagca ggaagagagc ctgaagaata tcaaggactc cctgcagcag     1560

tccagcggcc ggatcgacat catccacagc aagaaaacag ccgccctgca gtccgccacc     1620

cccgtggaaa gagtgaagct gcaggaagcc ctgagccagc tggacttcca gtgggagaaa     1680

gtgaacaaga tgtacaagga ccggcagggc agattcgacc gcagcgtgga aaagtggcgg     1740

cggttccact acgacatcaa gatcttcaac cagtggctga ccgaggccga gcagttcctg     1800

agaaagaccc agatccccga gaactgggag cacgccaagt acaagtggta tctgaaagaa     1860

ctgcaggatg gcatcggcca gcggcagacc gtggtgcgca cactgaatgc caccggcgag     1920

gaaatcatcc agcagagcag caagaccgac gccagcatcc tgcaggaaaa gctgggctcc     1980

ctgaacctgc ggtggcagga agtgtgcaag cagctgagcg accggaagaa gaggctggaa     2040

gaacaggccc ctggcctgac caccatcggc gccagcccta cccagaccgt gaccctggtg     2100

acacagcccg tggtgacaaa agagacagcc atctccaagc tggaaatgcc cagctccctg     2160

atgctggaag tacctgctct ggcagatttc aaccgggctt ggacagaact taccgactgg     2220

ctttctctgc ttgatcaagt tataaaatca cagagggtga tggtgggtga ccttgaggat     2280

atcaacgaga tgatcatcaa gcagaaggca acaatgcagg atttggaaca gaggcgtccc     2340

cagttggaag aactcattac cgctgcccaa aatttgaaaa acaagaccag caatcaagag     2400

gctagaacaa tcattacgga tcgaattgaa agaattcaga atcagtggga tgaagtacaa     2460

gaacaccttc agaaccggag gcaacagttg aatgaaatgc tggaaaggct gcaggaactg     2520

caggaggcca ccgacgagct ggacctgaag ctgcggcagg ccgaagtgat caagggcagc     2580

tggcagcccg tgggcgacct gctgatcgac agcctgcagg accacctgga aaaagtgaag     2640

gccctgagag gcgagatcgc ccccctgaaa gaaaacgtgt cccacgtgaa cgacctggcc     2700

cggcagctga ccaccctggg catccagctg agcccctaca acctgagcac cctggaagat     2760

ctgaacaccc ggtggaagct gctgcaggtg gccgtggaag atagagtgcg gcagctgcac     2820

gaggcccaca gagactttgg ccctgccagc cagcacttcc tgagcacctc tgtgcaggga     2880

ccctgggaga gagccatcag ccccaacaag gtgccctact acatcaacca cgagacacag     2940

accacctgtt gggaccaccc caagatgacc gagctgtacc agagcctggc cgacctgaac     3000

aatgtgcggt tcagcgccta ccggaccgcc atgaagctga ggcggctgca gaaagctctg     3060

tgcctggatc tgctgagcct gagcgccgcc tgcgacgccc tggaccagca caacctgaag     3120

cagaacgacc agcccatgga tatcctgcag atcatcaact gcctgaccac aatctacgac     3180

aggctggaac aggaacacaa caatctggtc aacgtgcccc tgtgcgtgga catgtgcctg     3240

aattggctgc tgaatgtgta cgacaccggc cggaccggca gaatccgggt gctgagcttc     3300

aagaccggca tcatcagcct gtgcaaggcc cacctggaag ataagtaccg ctacctgttc     3360

aaacaggtgg ccagctccac cggcttttgc gaccagcgga gactgggcct gctgctgcac     3420

gacagcatcc agatccccag acagctgggc gaggtggcct ccttcggcgg cagcaacatt     3480

gagcccagcg tgcggagctg cttccagttc gccaacaaca agcccgagat cgaggccgcc     3540

ctgttcctgg actggatgag actggaaccc cagagcatgg tgtggctgcc cgtgctgcat     3600

cgggtggccg ctgccgagac agccaagcac caggccaagt gcaacatctg caaagagtgc     3660

cccatcatcg gcttccggta cagaagcctg aagcacttca actacgatat ctgccagagc     3720

tgcttcttca gcggcagagt ggccaagggc cacaaaatgc actaccccat ggtggaatac     3780

tgcaccccca ccaccagcgg cgaggatgtg cgggacttcg ccaaggtgct gaaaaacaag     3840

ttccggacca agcggtactt tgccaagcac ccccggatgg gctacctgcc cgtgcagaca     3900

gtgctggaag gcgacaacat ggaaacccct gcccagatcc tgatcagcct ggaaagcgag     3960

gaacggggcg agctggaacg gatcctggcc gatctggaag aggaaaaccg gaacctgcag     4020

gccgagtacg accggctgaa gcagcagcac gagcacaagg gcctgagccc cctgcctagc     4080

ccccctgaca ccatgtgatg atgatttggg cagagcgatg gagtccttag tatcagtcat     4140

gacagatgaa gaaggagcag aataaatgtt ttacaactcc tgattcccgc atgcggccag     4200

cttatcgata ccgtcgaaat aaaagatcct tattttcatt ggatctgtgt gttggttttt     4260

tgtgtg                                                                4266


<210>  146
<211>  4320
<212>  DNA
<213>  Homo sapiens

<400>  146
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtcaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggatctgc tggaaggcct gaccggacag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctcgtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaagtg      360

aagaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag caccagaaac tacccccaag tgaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaat gccctgatcc acagccacag acccgacctg      540

ttcgactgga acagcgtcgt gtgtcagcag agcgccaccc agaggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg accccgagga tgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgcct      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact actctcagca gatcaccgtg      840

tccctggccc agggctacga gagaaccagc agccccaagc cccggttcaa gagctacgcc      900

tatacccagg ccgcctacgt gaccaccagc gaccctacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggatagat accagaccgc cctggaagag gtgctgtcct ggctgctgag cgccgaggat     1080

acactgcagg ctcagggcga gatcagcaac gacgtggaag tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg caacattctg     1200

cagctgggct ccaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgagagtggc cagcatggaa     1320

aagcagagca acctgcaccg ggtgctgatg gatctgcaga accagaagct gaaagagctg     1380

aacgactggc tgaccaagac cgaggaacgg acccggaaga tggaagagga acccctggga     1440

ccagacctgg aagatctgaa aagacaggtg cagcagcaca aagtgctgca ggaagatctg     1500

gaacaggaac aggtgcgcgt gaacagcctg acccacatgg tcgtggtggt ggacgagagc     1560

agcggcgatc atgccacagc cgctctggaa gaacagctga aggtgctggg cgacagatgg     1620

gccaacatct gccggtggac cgaggataga tgggtgctgc tgcaggacat cctgctgaag     1680

tggcagcggc tgacagagga acagtgcctg ttctccgcct ggctgtccga gaaagaggac     1740

gccgtgaaca aaatccacac caccggcttc aaggaccaga acgagatgct gagcagcctg     1800

cagaaactgg ccgtgctgaa ggccgacctg gaaaagaaaa agcagtccat gggcaagctg     1860

tactccctga agcaggacct gctgtccacc ctgaagaaca agagcgtgac ccagaaaacc     1920

gaggcctggc tggacaactt cgcccggtgc tgggacaacc tggtgcagaa gctggaaaag     1980

tccaccgccc agatctccca ggccattcac accgtgcggg aagagacaat gatggtcatg     2040

actgaggaca tgcccctgga aatcagctac gtgccctcca cctacctgac cgagatcacc     2100

catgtgtccc aggccctgct ggaagtggaa cagctgctga acgcccccga tctgtgcgcc     2160

aaggacttcg aggatctgtt caagcaggaa gagagcctga agaatatcaa ggactctctg     2220

cagcagtcca gcggcagaat cgacatcatc cacagcaaga aaacagccgc cctgcagtcc     2280

gccacccccg tggaaagagt gaaactgcag gaagccctgt cccagctgga cttccagtgg     2340

gagaaagtga acaagatgta caaggaccgg cagggcagat tcgaccgcag cgtggaaaag     2400

tggcggcggt tccactacga catcaagatc ttcaaccagt ggctgaccga ggccgaacag     2460

ttcctgagaa agacccagat ccccgagaac tgggagcacg ccaagtacaa gtggtatctg     2520

aaagaactgc aggatggcat cggccagaga cagaccgtcg tgcggacact gaatgccacc     2580

ggcgaggaaa tcatccagca gagcagcaag accgacgcca gcatcctgca ggaaaagctg     2640

ggcagcctga acctgagatg gcaggaagtg tgcaagcagc tgtccgaccg gaagaagcgg     2700

ctggaagaac agctggaacg gctgcaggaa ctgcaggagg ccaccgacga gctggacctg     2760

aaactgagac aggccgaagt gatcaagggc agctggcagc cagtgggcga cctgctgatc     2820

gattctctgc aggaccacct ggaaaaagtg aaggccctga gaggcgagat cgcccccctg     2880

aaagaaaacg tgtcccacgt gaacgacctg gcccggcagc tgacaacact gggcatccag     2940

ctgagcccct acaacctgag cacactggaa gatctgaaca cccggtggaa gctgctgcag     3000

gtggccgtgg aagatagagt gcggcagctg cacgaggccc acagagattt tggccctgcc     3060

tcccagcact tcctgagcac ctcagtgcag ggcccttggg agagagccat ctcccctaac     3120

aaggtgccct actacatcaa ccacgagaca cagaccacct gttgggacca ccccaagatg     3180

accgagctgt accagagcct ggccgacctg aacaatgtgc ggttcagcgc ctaccggacc     3240

gccatgaagc tgcggagact gcagaaagct ctgtgcctgg atctgctgtc cctgagcgcc     3300

gcctgtgatg ccctggacca gcacaatctg aagcagaacg accagcccat ggatatcctg     3360

cagatcatta actgcctgac caccatctac gaccggctgg aacaggaaca caacaacctc     3420

gtgaacgtgc ccctgtgcgt ggacatgtgc ctgaattggc tgctgaatgt gtacgacacc     3480

ggccggacag gccggatcag agtgctgagc ttcaagaccg gcatcatcag cctgtgcaaa     3540

gcccatctgg aagataagta ccgctacctg ttcaaacagg tggccagctc taccggcttc     3600

tgcgatcaga gaaggctggg cctgctgctg catgactcca tccagatccc cagacagctg     3660

ggcgaggtgg cctctttcgg cggcagcaat atcgagccta gcgtgcggag ctgcttccag     3720

ttcgccaaca acaagcccga gatcgaggcc gccctgtttc tggactggat gagactggaa     3780

ccccagagca tggtgtggct gcccgtgctg catagagtgg ccgctgccga gacagccaag     3840

caccaggcca agtgcaatat ctgcaaagag tgccccatca tcggcttccg gtacagaagc     3900

ctgaagcact tcaactacga tatctgccag agctgtttct tcagcggcag ggtggccaag     3960

ggccacaaaa tgcactaccc catggtggaa tactgcaccc ccaccacaag cggagaggat     4020

gtgcgggact tcgccaaggt gctgaaaaac aagttccgga ccaagcggta tttcgccaaa     4080

cacccccgga tgggctacct gcctgtgcag acagtgctgg aaggcgacaa catggaaacc     4140

gacaccatgt gatgatgatt tgggcagagc gatggagtcc ttagtatcag tcatgacaga     4200

tgaagaagga gcagaataaa tgttttacaa ctcctgattc ccgcatgcgg ccagcttatc     4260

gataccgtcg aaataaaaga tccttatttt cattggatct gtgtgttggt tttttgtgtg     4320


<210>  147
<211>  4323
<212>  DNA
<213>  Homo sapiens

<400>  147
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggctc agggctacga gcggaccagc agccccaagc cccggttcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccaccagc gaccccacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgtcct ggctgctgag cgccgaggat     1080

acactgcagg cccagggcga gatcagcaac gacgtggaag tggtgaaaga ccagttccac     1140

acccacgagg gctacatgat ggacctgacc gcccaccagg gcagagtggg caacatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcacat ccacaccgtg cgggaagaga caatgatggt gatgaccgag     1380

gacatgcccc tggaaatcag ctacgtgccc agcacctacc tgaccgagat cacccacgtg     1440

tcccaggctc tgctggaagt ggaacagctg ctgaacgccc ccgacctgtg cgccaaggac     1500

ttcgaggatc tgttcaagca ggaagagagc ctgaagaata tcaaggactc cctgcagcag     1560

tccagcggcc ggatcgacat catccacagc aagaaaacag ccgccctgca gtccgccacc     1620

cccgtggaaa gagtgaagct gcaggaagcc ctgagccagc tggacttcca gtgggagaaa     1680

gtgaacaaga tgtacaagga ccggcagggc agattcgacc gcagcgtgga aaagtggcgg     1740

cggttccact acgacatcaa gatcttcaac cagtggctga ccgaggccga gcagttcctg     1800

agaaagaccc agatccccga gaactgggag cacgccaagt acaagtggta tctgaaagaa     1860

ctgcaggatg gcatcggcca gcggcagacc gtggtgcgca cactgaatgc caccggcgag     1920

gaaatcatcc agcagagcag caagaccgac gccagcatcc tgcaggaaaa gctgggctcc     1980

ctgaacctgc ggtggcagga agtgtgcaag cagctgagcg accggaagaa gaggctggaa     2040

gaacaggccc ctggcctgac caccatcggc gccagcccta cccagaccgt gaccctggtg     2100

acacagcccg tggtgacaaa agagacagcc atctccaagc tggaaatgcc cagctccctg     2160

atgctggaat ctgaccagtg gaagcgtctg cacctttctc tgcaggaact tctggtgtgg     2220

ctacagctga aagatgatga attaagccgg caggcaccta ttggaggcga ctttccagca     2280

gttcagaagc agaacgatgt acatagggcc ttcaagaggg aattgaaaac taaagaacct     2340

gtaatcatga gtactcttga gactgtacga atatttctga cagagcagcc tttggaagga     2400

ctagagaaac tctaccagga gcccagagag ctgcctcctg aggagagagc ccagaatgtc     2460

actcggcttc tacgaaagca ggctgaggag gtcaatactg agtgggaaaa attgaacctg     2520

cactccgctg actggcagag aaaaatagat gagaccctgg aaaggctgca ggaactgcag     2580

gaggccaccg acgagctgga cctgaagctg cggcaggccg aagtgatcaa gggcagctgg     2640

cagcccgtgg gcgacctgct gatcgacagc ctgcaggacc acctggaaaa agtgaaggcc     2700

ctgagaggcg agatcgcccc cctgaaagaa aacgtgtccc acgtgaacga cctggcccgg     2760

cagctgacca ccctgggcat ccagctgagc ccctacaacc tgagcaccct ggaagatctg     2820

aacacccggt ggaagctgct gcaggtggcc gtggaagata gagtgcggca gctgcacgag     2880

gcccacagag actttggccc tgccagccag cacttcctga gcacctctgt gcagggaccc     2940

tgggagagag ccatcagccc caacaaggtg ccctactaca tcaaccacga gacacagacc     3000

acctgttggg accaccccaa gatgaccgag ctgtaccaga gcctggccga cctgaacaat     3060

gtgcggttca gcgcctaccg gaccgccatg aagctgaggc ggctgcagaa agctctgtgc     3120

ctggatctgc tgagcctgag cgccgcctgc gacgccctgg accagcacaa cctgaagcag     3180

aacgaccagc ccatggatat cctgcagatc atcaactgcc tgaccacaat ctacgacagg     3240

ctggaacagg aacacaacaa tctggtcaac gtgcccctgt gcgtggacat gtgcctgaat     3300

tggctgctga atgtgtacga caccggccgg accggcagaa tccgggtgct gagcttcaag     3360

accggcatca tcagcctgtg caaggcccac ctggaagata agtaccgcta cctgttcaaa     3420

caggtggcca gctccaccgg cttttgcgac cagcggagac tgggcctgct gctgcacgac     3480

agcatccaga tccccagaca gctgggcgag gtggcctcct tcggcggcag caacattgag     3540

cccagcgtgc ggagctgctt ccagttcgcc aacaacaagc ccgagatcga ggccgccctg     3600

ttcctggact ggatgagact ggaaccccag agcatggtgt ggctgcccgt gctgcatcgg     3660

gtggccgctg ccgagacagc caagcaccag gccaagtgca acatctgcaa agagtgcccc     3720

atcatcggct tccggtacag aagcctgaag cacttcaact acgatatctg ccagagctgc     3780

ttcttcagcg gcagagtggc caagggccac aaaatgcact accccatggt ggaatactgc     3840

acccccacca ccagcggcga ggatgtgcgg gacttcgcca aggtgctgaa aaacaagttc     3900

cggaccaagc ggtactttgc caagcacccc cggatgggct acctgcccgt gcagacagtg     3960

ctggaaggcg acaacatgga aacccctgcc cagatcctga tcagcctgga aagcgaggaa     4020

cggggcgagc tggaacggat cctggccgat ctggaagagg aaaaccggaa cctgcaggcc     4080

gagtacgacc ggctgaagca gcagcacgag cacaagggcc tgagccccct gcctagcccc     4140

cctgacacca tgtgatgatg atttgggcag agcgatggag tccttagtat cagtcatgac     4200

agatgaagaa ggagcagaat aaatgtttta caactcctga ttcccgcatg cggccagctt     4260

atcgataccg tcgaaataaa agatccttat tttcattgga tctgtgtgtt ggttttttgt     4320

gtg                                                                   4323


<210>  148
<211>  4164
<212>  DNA
<213>  Homo sapiens

<400>  148
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggctc agggctacga gcggaccagc agccccaagc cccggttcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccaccagc gaccccacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgtcct ggctgctgag cgccgaggat     1080

acactgcagg cccagggcga gatcagcaac gacgtggaag tggtgaaaga ccagttccac     1140

acccacgagg gctacatgat ggacctgacc gcccaccagg gcagagtggg caacatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcacat ccacaccgtg cgggaagaga caatgatggt gatgaccgag     1380

gacatgcccc tggaaatcag ctacgtgccc agcacctacc tgaccgagat cacccacgtg     1440

tcccaggctc tgctggaagt ggaacagctg ctgaacgccc ccgacctgtg cgccaaggac     1500

ttcgaggatc tgttcaagca ggaagagagc ctgaagaata tcaaggactc cctgcagcag     1560

tccagcggcc ggatcgacat catccacagc aagaaaacag ccgccctgca gtccgccacc     1620

cccgtggaaa gagtgaagct gcaggaagcc ctgagccagc tggacttcca gtgggagaaa     1680

gtgaacaaga tgtacaagga ccggcagggc agattcgacc gcagcgtgga aaagtggcgg     1740

cggttccact acgacatcaa gatcttcaac cagtggctga ccgaggccga gcagttcctg     1800

agaaagaccc agatccccga gaactgggag cacgccaagt acaagtggta tctgaaagag     1860

ctgcaggacg gcatcggcca gcggcagaca gtggtccgca ccctgaatgc caccggcgag     1920

gaaatcatcc agcagagcag caagaccgac gccagcatcc tgcaggaaaa gctgggcagc     1980

ctgaacctgc ggtggcagga agtgtgcaag cagctgagcg accggaagaa gcggctggaa     2040

gaacaggccc ctggcctgac cacaatcggc gccagcccta cccagaccgt gaccctggtg     2100

acacagcccg tggtgacaaa agagacagcc atcagcaagc tggaaatgcc cagcagcctg     2160

atgctggaaa gcgaccagtg gaagcggctg cacctgagcc tgcaggaact gctggtctgg     2220

ctgcagctga aggacgacga gctgagcaga caggccccca tcggcggcga tttccccgcc     2280

gtgcagaaac agaacgacgt gcaccgggcc ttcaagcgcg agctgaaaac aaaagaaccc     2340

gtgatcatga gcaccctgga aaccgtgcgg atcttcctga ccgagcagcc cctggaaggc     2400

ctggaaaagc tgtaccagga acccagagag ctgccccccg aggaacgggc ccagaacgtg     2460

accagactgc tgcggaagca ggccgaagag gtcaacaccg agtgggagaa gctgaacctg     2520

cacagcgccg actggcagcg gaagatcgac gagacactgg aacggctgca ggaactgcag     2580

gaggccaccg acgagctgga cctgaagctg agacaggccg aagtgatcaa gggcagctgg     2640

cagcccgtgg gcgacctgct gatcgactcc ctgcaggacc acctggaaaa agtgaaggcc     2700

ctgcggggcg agatcgcccc cctgaaagaa aacgtgtccc acgtgaacga cctggcccgg     2760

cagctgacca ccctgggcat ccagctgagc ccctacaacc tgtccaccct ggaagatctg     2820

aacacccggt ggaagctgct gcaggtggcc gtggaagata gagtgcggca gctgcacgag     2880

gcccacagag actttggccc tgccagccag cacttcctga gcacctctgt gcagggaccc     2940

tgggagagag ccatcagccc caacaaggtg ccctactaca tcaaccacga gacacagacc     3000

acctgttggg accaccccaa gatgaccgag ctgtaccaga gcctggccga cctgaacaat     3060

gtgcggttca gcgcctaccg gaccgccatg aagctgaggc ggctgcagaa agctctgtgc     3120

ctggatctgc tgagcctgag cgccgcctgc gacgccctgg accagcacaa cctgaagcag     3180

aacgaccagc ccatggatat cctgcagatc atcaactgcc tgaccacaat ctacgacagg     3240

ctggaacagg aacacaacaa tctggtcaac gtgcccctgt gcgtggacat gtgcctgaat     3300

tggctgctga atgtgtacga caccggccgg accggcagaa tccgggtgct gagcttcaag     3360

accggcatca tcagcctgtg caaggcccac ctggaagata agtaccgcta cctgttcaaa     3420

caggtggcca gctccaccgg cttttgcgac cagcggagac tgggcctgct gctgcacgac     3480

agcatccaga tccccagaca gctgggcgag gtggcctcct tcggcggcag caacattgag     3540

cccagcgtgc ggagctgctt ccagttcgcc aacaacaagc ccgagatcga ggccgccctg     3600

ttcctggact ggatgagact ggaaccccag agcatggtgt ggctgcccgt gctgcatcgg     3660

gtggccgctg ccgagacagc caagcaccag gccaagtgca acatctgcaa agagtgcccc     3720

atcatcggct tccggtacag aagcctgaag cacttcaact acgatatctg ccagagctgc     3780

ttcttcagcg gcagagtggc caagggccac aaaatgcact accccatggt ggaatactgc     3840

acccccacca ccagcggcga ggatgtgcgg gacttcgcca aggtgctgaa aaacaagttc     3900

cggaccaagc ggtactttgc caagcacccc cggatgggct acctgcccgt gcagacagtg     3960

ctggaaggcg acaacatgga aaccgacacc atgtgatgat gatttgggca gagcgatgga     4020

gtccttagta tcagtcatga cagatgaaga aggagcagaa taaatgtttt acaactcctg     4080

attcccgcat gcggccagct tatcgatacc gtcgaaataa aagatcctta ttttcattgg     4140

atctgtgtgt tggttttttg tgtg                                            4164


<210>  149
<211>  4076
<212>  DNA
<213>  Homo sapiens

<400>  149
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggctc agggctacga gcggaccagc agccccaagc cccggttcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccaccagc gaccccacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgtcct ggctgctgag cgccgaggat     1080

acactgcagg cccagggcga gatcagcaac gacgtggaag tggtgaaaga ccagttccac     1140

acccacgagg gctacatgat ggacctgacc gcccaccagg gcagagtggg caacatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcacat ccacaccgtg cgggaagaga caatgatggt gatgaccgag     1380

gacatgcccc tggaaatcag ctacgtgccc agcacctacc tgaccgagat cacccacgtg     1440

tcccaggctc tgctggaagt ggaacagctg ctgaacgccc ccgacctgtg cgccaaggac     1500

ttcgaggatc tgttcaagca ggaagagagc ctgaagaata tcaaggactc cctgcagcag     1560

tccagcggcc ggatcgacat catccacagc aagaaaacag ccgccctgca gtccgccacc     1620

cccgtggaaa gagtgaagct gcaggaagcc ctgagccagc tggacttcca gtgggagaaa     1680

gtgaacaaga tgtacaagga ccggcagggc agattcgacc gcagcgtgga aaagtggcgg     1740

cggttccact acgacatcaa gatcttcaac cagtggctga ccgaggccga gcagttcctg     1800

agaaagaccc agatccccga gaactgggag cacgccaagt acaagtggta tctgaaagag     1860

ctgcaggacg gcatcggcca gcggcagaca gtggtccgca ccctgaatgc caccggcgag     1920

gaaatcatcc agcagagcag caagaccgac gccagcatcc tgcaggaaaa gctgggcagc     1980

ctgaacctgc ggtggcagga agtgtgcaag cagctgagcg accggaagaa gcggctggaa     2040

gaacaggccc ctggcctgac cacaatcggc gccagcccta cccagaccgt gaccctggtg     2100

acacagcccg tggtgacaaa agagacagcc atcagcaagc tggaaatgcc cagcagcctg     2160

atgctggaaa gcgaccagtg gaagcggctg cacctgagcc tgcaggaact gctggtctgg     2220

ctgcagctga aggacgacga gctgagcaga caggccccca tcggcggcga tttccccgcc     2280

gtgcagaaac agaacgacgt gcaccgggcc ttcaagcgcg agctgaaaac aaaagaaccc     2340

gtgatcatga gcaccctgga aaccgtgcgg atcttcctga ccgagcagcc cctggaaggc     2400

ctggaaaagc tgtaccagga acccagagag ctgccccccg aggaacgggc ccagaacgtg     2460

accagactgc tgcggaagca ggccgaagag gtcaacaccg agtgggagaa gctgaacctg     2520

cacagcgccg actggcagcg gaagatcgac gagacactgg aacggctgca ggaactgcag     2580

gaggccaccg acgagctgga cctgaagctg agacaggccg aagtgatcaa gggcagctgg     2640

cagcccgtgg gcgacctgct gatcgactcc ctgcaggacc acctggaaaa agtgaaggcc     2700

ctgcggggcg agatcgcccc cctgaaagaa aacgtgtccc acgtgaacga cctggcccgg     2760

cagctgacca ccctgggcat ccagctgagc ccctacaacc tgtccaccct ggaagatctg     2820

aacacccggt ggaagctgct gcaggtggcc gtggaagata gagtgcggca gctgcacgag     2880

gcccacagag actttggccc tgccagccag cacttcctga gcacctctgt gcagggaccc     2940

tgggagagag ccatcagccc caacaaggtg ccctactaca tcaaccacga gacacagacc     3000

acctgttggg accaccccaa gatgaccgag ctgtaccaga gcctggccga cctgaacaat     3060

gtgcggttca gcgcctaccg gaccgccatg aagctgaggc ggctgcagaa agctctgtgc     3120

ctggatctgc tgagcctgag cgccgcctgc gacgccctgg accagcacaa cctgaagcag     3180

aacgaccagc ccatggatat cctgcagatc atcaactgcc tgaccacaat ctacgacagg     3240

ctggaacagg aacacaacaa tctggtcaac gtgcccctgt gcgtggacat gtgcctgaat     3300

tggctgctga atgtgtacga caccggccgg accggcagaa tccgggtgct gagcttcaag     3360

accggcatca tcagcctgtg caaggcccac ctggaagata agtaccgcta cctgttcaaa     3420

caggtggcca gctccaccgg cttttgcgac cagcggagac tgggcctgct gctgcacgac     3480

agcatccaga tccccagaca gctgggcgag gtggcctcct tcggcggcag caacattgag     3540

cccagcgtgc ggagctgctt ccagttcgcc aacaacaagc ccgagatcga ggccgccctg     3600

ttcctggact ggatgagact ggaaccccag agcatggtgt ggctgcccgt gctgcatcgg     3660

gtggccgctg ccgagacagc caagcaccag gccaagtgca acatctgcaa agagtgcccc     3720

atcatcggct tccggtacag aagcctgaag cacttcaact acgatatctg ccagagctgc     3780

ttcttcagcg gcagagtggc caagggccac aaaatgcact accccatggt ggaatactgc     3840

acccccacca ccagcggcga ggatgtgcgg gacttcgcca aggtgctgaa aaacaagttc     3900

cggaccaagc ggtactttgc caagcacccc cggatgggct acctgcccgt gcagacagtg     3960

ctggaaggcg acaacatgga aaccgacacc atgtgatgat gagaagtctt ttccacatgg     4020

cagatgaaat aaaagatcct tattttcatt ggatctgtgt gttggttttt tgtgtg         4076


<210>  150
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  150
gccrccaugg                                                              10


<210>  151
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  151
gccaccatgg                                                              10


<210>  152
<211>  1332
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Ile His 
        435                 440                 445             


Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu 
    450                 455                 460                 


Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val 
465                 470                 475                 480 


Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu 
                485                 490                 495     


Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys 
            500                 505                 510         


Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile 
        515                 520                 525             


His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg 
    530                 535                 540                 


Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys 
545                 550                 555                 560 


Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val 
                565                 570                 575     


Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp 
            580                 585                 590         


Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn 
        595                 600                 605             


Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly 
    610                 615                 620                 


Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu 
625                 630                 635                 640 


Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu 
                645                 650                 655     


Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu 
            660                 665                 670         


Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Lys Asn Asp Leu Ala Pro 
        675                 680                 685             


Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val 
    690                 695                 700                 


Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met 
705                 710                 715                 720 


Pro Ser Ser Leu Met Leu Glu Ser Asp Gln Trp Lys Arg Leu His Leu 
                725                 730                 735     


Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu 
            740                 745                 750         


Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln 
        755                 760                 765             


Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro 
    770                 775                 780                 


Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln 
785                 790                 795                 800 


Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro 
                805                 810                 815     


Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala 
            820                 825                 830         


Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp 
        835                 840                 845             


Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln 
    850                 855                 860                 


Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile 
865                 870                 875                 880 


Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln 
                885                 890                 895     


Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu 
            900                 905                 910         


Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr 
        915                 920                 925             


Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu 
    930                 935                 940                 


Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg 
945                 950                 955                 960 


Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe 
                965                 970                 975     


Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn 
            980                 985                 990         


Lys Val Pro Tyr Tyr Ile Asn His  Glu Thr Gln Thr Thr  Cys Trp Asp 
        995                 1000                 1005             


His Pro  Lys Met Thr Glu Leu  Tyr Gln Ser Leu Ala  Asp Leu Asn 
    1010                 1015                 1020             


Asn Val  Arg Phe Ser Ala Tyr  Arg Thr Ala Met Lys  Leu Arg Arg 
    1025                 1030                 1035             


Leu Gln  Lys Ala Leu Cys Leu  Asp Leu Leu Ser Leu  Ser Ala Ala 
    1040                 1045                 1050             


Cys Asp  Ala Leu Asp Gln His  Asn Leu Lys Gln Asn  Asp Gln Pro 
    1055                 1060                 1065             


Met Asp  Ile Leu Gln Ile Ile  Asn Cys Leu Thr Thr  Ile Tyr Asp 
    1070                 1075                 1080             


Arg Leu  Glu Gln Glu His Asn  Asn Leu Val Asn Val  Pro Leu Cys 
    1085                 1090                 1095             


Val Asp  Met Cys Leu Asn Trp  Leu Leu Asn Val Tyr  Asp Thr Gly 
    1100                 1105                 1110             


Arg Thr  Gly Arg Ile Arg Val  Leu Ser Phe Lys Thr  Gly Ile Ile 
    1115                 1120                 1125             


Ser Leu  Cys Lys Ala His Leu  Glu Asp Lys Tyr Arg  Tyr Leu Phe 
    1130                 1135                 1140             


Lys Gln  Val Ala Ser Ser Thr  Gly Phe Cys Asp Gln  Arg Arg Leu 
    1145                 1150                 1155             


Gly Leu  Leu Leu His Asp Ser  Ile Gln Ile Pro Arg  Gln Leu Gly 
    1160                 1165                 1170             


Glu Val  Ala Ser Phe Gly Gly  Ser Asn Ile Glu Pro  Ser Val Arg 
    1175                 1180                 1185             


Ser Cys  Phe Gln Phe Ala Asn  Asn Lys Pro Glu Ile  Glu Ala Ala 
    1190                 1195                 1200             


Leu Phe  Leu Asp Trp Met Arg  Leu Glu Pro Gln Ser  Met Val Trp 
    1205                 1210                 1215             


Leu Pro  Val Leu His Arg Val  Ala Ala Ala Glu Thr  Ala Lys His 
    1220                 1225                 1230             


Gln Ala  Lys Cys Asn Ile Cys  Lys Glu Cys Pro Ile  Ile Gly Phe 
    1235                 1240                 1245             


Arg Tyr  Arg Ser Leu Lys His  Phe Asn Tyr Asp Ile  Cys Gln Ser 
    1250                 1255                 1260             


Cys Phe  Phe Ser Gly Arg Val  Ala Lys Gly His Lys  Met His Tyr 
    1265                 1270                 1275             


Pro Met  Val Glu Tyr Cys Thr  Pro Thr Thr Ser Gly  Glu Asp Val 
    1280                 1285                 1290             


Arg Asp  Phe Ala Lys Val Leu  Lys Asn Lys Phe Arg  Thr Lys Arg 
    1295                 1300                 1305             


Tyr Phe  Ala Lys His Pro Arg  Met Gly Tyr Leu Pro  Val Gln Thr 
    1310                 1315                 1320             


Val Leu  Glu Gly Asp Asn Met  Glu Thr 
    1325                 1330         


<210>  153
<211>  1322
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala 
    450                 455                 460                 


Trp Leu Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly 
465                 470                 475                 480 


Phe Lys Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val 
                485                 490                 495     


Leu Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr 
            500                 505                 510         


Ser Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr 
        515                 520                 525             


Gln Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn 
    530                 535                 540                 


Leu Val Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val 
545                 550                 555                 560 


Thr Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val 
                565                 570                 575     


Thr Thr Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu 
            580                 585                 590         


Glu Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp 
        595                 600                 605             


Ser Glu Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu 
    610                 615                 620                 


Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu 
625                 630                 635                 640 


Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn 
                645                 650                 655     


Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu 
            660                 665                 670         


Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg 
        675                 680                 685             


Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr 
    690                 695                 700                 


Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe 
705                 710                 715                 720 


Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe 
                725                 730                 735     


Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile 
            740                 745                 750         


Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln 
        755                 760                 765             


Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu 
    770                 775                 780                 


Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn 
785                 790                 795                 800 


Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser 
                805                 810                 815     


Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val 
            820                 825                 830         


Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu Gln Leu Glu 
        835                 840                 845             


Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu 
    850                 855                 860                 


Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu 
865                 870                 875                 880 


Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg 
                885                 890                 895     


Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu 
            900                 905                 910         


Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu 
        915                 920                 925             


Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala 
    930                 935                 940                 


Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly 
945                 950                 955                 960 


Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu 
                965                 970                 975     


Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 
            980                 985                 990         


Gln Thr Thr Cys Trp Asp His Pro  Lys Met Thr Glu Leu  Tyr Gln Ser 
        995                 1000                 1005             


Leu Ala  Asp Leu Asn Asn Val  Arg Phe Ser Ala Tyr  Arg Thr Ala 
    1010                 1015                 1020             


Met Lys  Leu Arg Arg Leu Gln  Lys Ala Leu Cys Leu  Asp Leu Leu 
    1025                 1030                 1035             


Ser Leu  Ser Ala Ala Cys Asp  Ala Leu Asp Gln His  Asn Leu Lys 
    1040                 1045                 1050             


Gln Asn  Asp Gln Pro Met Asp  Ile Leu Gln Ile Ile  Asn Cys Leu 
    1055                 1060                 1065             


Thr Thr  Ile Tyr Asp Arg Leu  Glu Gln Glu His Asn  Asn Leu Val 
    1070                 1075                 1080             


Asn Val  Pro Leu Cys Val Asp  Met Cys Leu Asn Trp  Leu Leu Asn 
    1085                 1090                 1095             


Val Tyr  Asp Thr Gly Arg Thr  Gly Arg Ile Arg Val  Leu Ser Phe 
    1100                 1105                 1110             


Lys Thr  Gly Ile Ile Ser Leu  Cys Lys Ala His Leu  Glu Asp Lys 
    1115                 1120                 1125             


Tyr Arg  Tyr Leu Phe Lys Gln  Val Ala Ser Ser Thr  Gly Phe Cys 
    1130                 1135                 1140             


Asp Gln  Arg Arg Leu Gly Leu  Leu Leu His Asp Ser  Ile Gln Ile 
    1145                 1150                 1155             


Pro Arg  Gln Leu Gly Glu Val  Ala Ser Phe Gly Gly  Ser Asn Ile 
    1160                 1165                 1170             


Glu Pro  Ser Val Arg Ser Cys  Phe Gln Phe Ala Asn  Asn Lys Pro 
    1175                 1180                 1185             


Glu Ile  Glu Ala Ala Leu Phe  Leu Asp Trp Met Arg  Leu Glu Pro 
    1190                 1195                 1200             


Gln Ser  Met Val Trp Leu Pro  Val Leu His Arg Val  Ala Ala Ala 
    1205                 1210                 1215             


Glu Thr  Ala Lys His Gln Ala  Lys Cys Asn Ile Cys  Lys Glu Cys 
    1220                 1225                 1230             


Pro Ile  Ile Gly Phe Arg Tyr  Arg Ser Leu Lys His  Phe Asn Tyr 
    1235                 1240                 1245             


Asp Ile  Cys Gln Ser Cys Phe  Phe Ser Gly Arg Val  Ala Lys Gly 
    1250                 1255                 1260             


His Lys  Met His Tyr Pro Met  Val Glu Tyr Cys Thr  Pro Thr Thr 
    1265                 1270                 1275             


Ser Gly  Glu Asp Val Arg Asp  Phe Ala Lys Val Leu  Lys Asn Lys 
    1280                 1285                 1290             


Phe Arg  Thr Lys Arg Tyr Phe  Ala Lys His Pro Arg  Met Gly Tyr 
    1295                 1300                 1305             


Leu Pro  Val Gln Thr Val Leu  Glu Gly Asp Asn Met  Glu Thr 
    1310                 1315                 1320         


<210>  154
<211>  4043
<212>  DNA
<213>  Homo sapiens

<400>  154
atgctgtggt gggaggaagt ggaagattgc tacgagcgcg aggacgtgca gaagaaaacc       60

ttcaccaaat gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggacgg cagacggctg ctggacctgc tggaaggcct gaccggccag      180

aagctgccca aagagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgcgggtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtc      360

aaaaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgcgccagag cacccggaac tacccccagg tcaacgtgat caacttcacc      480

acctcttgga gcgacggcct ggccctgaac gccctgatcc acagccaccg gcccgacctg      540

ttcgactgga acagcgtggt ctgccagcag agcgccaccc agcggctgga acacgccttc      600

aatatcgcca gataccagct gggcatcgag aagctgctgg atcccgagga cgtggacacc      660

acctaccccg acaagaaatc catcctgatg tatatcacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccagacc ccccaaagtg      780

accaaagagg aacacttcca gctgcaccac cagatgcact acagccagca gatcaccgtg      840

tccctggccc agggctacga gagaaccagc agccccaagc cccggttcaa gagctacgcc      900

tatacccagg ccgcctacgt gaccaccagc gaccctacca gaagcccatt ccccagccag      960

catctggaag cccccgagga caagagcttc ggcagcagcc tgatggaaag cgaagtgaac     1020

ctggacagat accagaccgc cctggaagag gtgctgagct ggctgctgag cgccgaggat     1080

acactgcagg ctcagggcga gatcagcaac gacgtggaag tcgtgaagga ccagttccac     1140

acccacgagg gctacatgat ggacctgaca gcccaccagg gcagagtggg caacatcctg     1200

cagctgggct ccaagctgat cggcaccggc aagctgagcg aggacgaaga gacagaggtg     1260

caggaacaga tgaacctgct gaacagcaga tgggagtgcc tgcgggtggc cagcatggaa     1320

aagcagagca acctgcatag ggtcctgctg aagtggcagc ggctgaccga ggaacagtgc     1380

ctgtttagcg cctggctgtc cgagaaagag gacgccgtga acaagatcca caccaccggc     1440

ttcaaggacc agaacgagat gctgagcagc ctgcagaaac tggccgtgct gaaggccgac     1500

ctggaaaaga aaaagcagtc catgggcaag ctgtactccc tgaagcagga cctgctgtcc     1560

accctgaaga acaagagcgt gacccagaaa accgaggcct ggctggacaa cttcgcccgg     1620

tgctgggaca acctggtgca gaagctggaa aagtccaccg cccagatctc ccaggccgtg     1680

accacaacac agcccagcct gacccagacc accgtgatgg aaaccgtgac aacagtgacc     1740

acccgggaac agatcctcgt gaagcacgcc caggaagaac tgccccctcc acccccccag     1800

aagaaacggc agatcacagt ggacagtgaa atccacaccg tgcgggaaga gacaatgatg     1860

gtcatgacag aggacatgcc cctggaaatc agctacgtgc ccagcaccta cctgaccgag     1920

atcacccatg tgtcccaggc cctgctggaa gtggaacagc tgctgaacgc ccccgacctg     1980

tgcgccaagg atttcgagga cctgttcaag caggaagaga gcctgaagaa tatcaaggat     2040

agcctgcagc agagcagcgg ccggatcgac atcatccaca gcaagaaaac agccgccctg     2100

cagagcgcca cccccgtgga aagagtgaaa ctgcaggaag ccctgtccca gctggacttc     2160

cagtgggaga aagtgaacaa aatgtacaag gaccggcagg gcagattcga ccgcagcgtg     2220

gaaaagtggc ggcggttcca ctacgacatc aagatcttca accagtggct gacagaggcc     2280

gagcagttcc tgagaaagac ccagatcccc gagaactggg agcacgccaa gtacaagtgg     2340

tatctgaaag agctgcagga cggcatcggc cagagacaga cagtcgtgcg gaccctgaat     2400

gccaccggcg aggaaatcat ccagcagtcc agcaagaccg acgccagcat tctgcaggaa     2460

aagctgggca gcctgaacct gcggtggcag gaagtgtgca agcagctgtc cgaccggaag     2520

aagcggctgg aagaacagct ggaacggctg caggaactgc aggaggccac cgacgagctg     2580

gacctgaaac tgagacaggc cgaagtgatc aagggcagct ggcagccagt gggcgacctg     2640

ctgatcgact ccctgcagga ccatctggaa aaagtgaagg ccctgagagg cgagatcgcc     2700

cccctgaaag aaaacgtgtc ccacgtgaac gacctggccc ggcagctgac aacactgggc     2760

attcagctga gcccctacaa cctgagcaca ctggaagatc tgaacacccg gtggaagctg     2820

ctgcaggtgg ccgtggaaga tagagtgcgg cagctgcacg aggcccacag agattttggc     2880

cctgcctccc agcacttcct gagcaccagt gtgcagggcc cttgggagag agccatctcc     2940

cctaacaagg tgccctacta catcaaccac gagacacaga ccacctgttg ggaccacccc     3000

aagatgaccg agctgtacca gagcctggct gacctgaaca acgtgcggtt cagcgcctac     3060

cggaccgcca tgaagctgcg gagactgcag aaagctctgt gcctggatct gctgtccctg     3120

tccgccgcct gtgatgccct ggaccagcac aatctgaagc agaacgacca gcccatggat     3180

atcctgcaga tcatcaactg cctgaccacc atctacgacc ggctggaaca ggaacacaac     3240

aatctcgtga acgtgcccct gtgcgtggac atgtgcctga attggctgct gaatgtgtac     3300

gacaccggcc ggacaggccg gatcagagtg ctgtccttca agaccggcat catcagcctg     3360

tgcaaagccc acctggaaga taagtaccgg tatctgttca aacaggtggc ctctagcacc     3420

ggcttttgcg accagagaag gctgggcctg ctgctgcacg acagcatcca gatccctaga     3480

cagctgggcg aagtggccag ctttggcggc agcaacatcg agcctagcgt gcggagctgc     3540

ttccagttcg ccaacaacaa gcccgagatc gaggccgccc tgttcctgga ctggatgaga     3600

ctggaacccc agagcatggt gtggctgccc gtgctgcata gagtggccgc tgccgagaca     3660

gccaagcacc aggccaagtg caacatctgc aaagagtgcc ccatcatcgg cttccggtac     3720

agaagcctga agcacttcaa ctacgatatc tgccagagct gtttcttcag cggcagggtg     3780

gccaagggcc acaaaatgca ctaccccatg gtggaatact gcacccccac cacaagcggc     3840

gaggatgtgc gggatttcgc caaggtgctg aaaaacaagt tccggaccaa gcggtacttc     3900

gccaaacacc cccggatggg ctacctgcct gtgcagacag tgctggaagg cgacaacatg     3960

gaaacctgag aagtcttttc cacatggcag atgaaataaa agatccttat tttcattgga     4020

tctgtgtgtt ggttttttgt gtg                                             4043


<210>  155
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  155

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ile 
1               5                   10                  15      


His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro 
            20                  25                  30          


Leu Glu Ile 
        35  


<210>  156
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  156

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser 
1               5                   10                  15      


Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met 
            20                  25                  30          


Pro Leu Glu Ile 
        35      


<210>  157
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  157

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser 
1               5                   10                  15      


Glu Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp 
            20                  25                  30          


Met Pro Leu Glu Ile 
        35          


<210>  158
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  158

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Gln 
1               5                   10                  15      


Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met 
            20                  25                  30          


Pro Leu Glu Ile 
        35      


<210>  159
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  159

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ala 
1               5                   10                  15      


Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp 
            20                  25                  30          


Met Pro Leu Glu Ile 
        35          


<210>  160
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  160

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Ile His 
1               5                   10                  15      


Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu 
            20                  25                  30          


Glu Ile 
        


<210>  161
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  161

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp His 
1               5                   10                  15      


Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu 
            20                  25                  30          


Glu Ile 
        


<210>  162
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  162

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val His Thr 
1               5                   10                  15      


Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu Glu 
            20                  25                  30          


Ile 
    


<210>  163
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  163

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser 
1               5                   10                  15      


Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp 
            20                  25                  30          


Met Pro Leu Glu Ile 
        35          


<210>  164
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  164

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser 
1               5                   10                  15      


His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro 
            20                  25                  30          


Leu Glu Ile 
        35  


<210>  165
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  165

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Gln Ile 
1               5                   10                  15      


His Thr Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro 
            20                  25                  30          


Leu Glu Ile 
        35  


<210>  166
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  166

Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ala Gln Ile His Thr 
1               5                   10                  15      


Val Arg Glu Glu Thr Met Met Val 
            20                  


