                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Inovio Pharmaceuticals, Inc.
       Weiner, David
       Wise, Megan C
       Zu, Ziyang
 
<120>  DNA Antibody Constructs for Use Against HIV

<130>  206194-0011-20WO

<150>  US 62/750,213
<151>  2018-10-24

<160>  156   

<170>  PatentIn version 3.5

<210>  1
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG1 antibody

<400>  1

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile 
        35                  40                  45              


Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro 
65                  70                  75                  80  


Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp 
                85                  90                  95      


Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp 
        115                 120                 125             


Phe Asp Val Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly 
465                 470                 475                 480 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                485                 490                 495     


Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu 
            500                 505                 510         


Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser 
        515                 520                 525             


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys 
    530                 535                 540                 


Gln Ala Asn Gly Tyr Leu Asn Trp Tyr Gln Gln Arg Arg Gly Lys Ala 
545                 550                 555                 560 


Pro Lys Leu Leu Ile Tyr Asp Gly Ser Lys Leu Glu Arg Gly Val Pro 
                565                 570                 575     


Ser Arg Phe Ser Gly Arg Arg Trp Gly Gln Glu Tyr Asn Leu Thr Ile 
            580                 585                 590         


Asn Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Val Tyr 
        595                 600                 605             


Glu Phe Val Val Pro Gly Thr Arg Leu Asp Leu Lys Arg Thr Val Ala 
    610                 615                 620                 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
625                 630                 635                 640 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
                645                 650                 655     


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
            660                 665                 670         


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
        675                 680                 685             


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
    690                 695                 700                 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Arg Ser Pro Val Thr Lys 
705                 710                 715                 720 


Ser Phe Asn Arg Gly Glu Cys 
                725         


<210>  2
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG1 antibody

<400>  2
ggatccgcca ccatggattg gacatggaga attctgtttc tggtcgccgc cgctaccgga       60

actcacgctc aggtgcagct gctgcagtca ggggccgcag tgacaaagcc aggggcaagt      120

gtccgcgtgt catgcgaggc cagcggctac aacatccggg actatttcat tcactggtgg      180

cgacaggcac ctggacaggg actgcagtgg gtggggtgga tcaatccaaa gaccggccag      240

cccaacaatc ctaggcagtt ccagggcaga gtgagcctga cccggcatgc ttcctgggac      300

tttgatacat tctcttttta catggacctg aaggcactga ggagtgacga taccgccgtg      360

tacttctgcg ctagacagcg gtcagattat tgggactttg acgtgtgggg cagcggaact      420

caggtcaccg tgagctccgc cagtacaaag ggaccttcag tgtttccact ggctccctct      480

agtaaaagca catccggcgg aactgccgct ctgggatgtc tggtgaagga ctacttccct      540

gagccagtca ccgtgtcctg gaactctgga gctctgacta gcggggtcca cacctttcca      600

gcagtgctgc agtcaagcgg cctgtactcc ctgtcctctg tggtcactgt ccccagttca      660

agcctgggaa ctcagaccta tatctgcaac gtgaatcaca agccaagtaa taccaaagtc      720

gacaagaaag tggagcccaa gtcctgtgat aaaacacata cttgccctcc ctgtccagct      780

cctgaactgc tgggcggccc aagcgtgttc ctgtttccac ccaagcctaa agacactctg      840

atgatttcta gaacccctga ggtcacatgc gtggtcgtgg acgtgagcca cgaggacccc      900

gaagtcaagt tcaactggta cgtggatggc gtcgaagtgc ataatgccaa gaccaaaccc      960

cgagaggaac agtacaactc tacttatagg gtcgtgagtg tcctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtataagtgc aaagtgtcca ataaggctct gccagcaccc     1080

atcgaaaaaa caatttctaa ggccaaagga cagcctagag agccacaggt gtacactctg     1140

cctccatccc gggacgaact gacaaagaac caggtctctc tgacttgtct ggtgaaagga     1200

ttctatccca gcgatatcgc tgtggagtgg gaatccaatg ggcagcctga gaacaattac     1260

aagaccacac cccctgtgct ggacagtgat gggtcattct ttctgtattc caagctgaca     1320

gtggacaaat ctcggtggca gcagggcaac gtcttttctt gcagtgtgat gcatgaagcc     1380

ctgcacaatc attacacaca gaagtcactg agcctgtccc caggaaagcg aggacgaaaa     1440

aggagatctg ggagtggcgc tactaacttc tctctgctga aacaggcagg agatgtggag     1500

gaaaatcctg ggccaatggt cctgcagacc caggtgttta tctcactgct gctgtggatt     1560

agcggcgcat atggagacat ccagatgaca cagagccctt cctctctgtc agcaagcgtc     1620

ggcgataccg tgacaattac ttgtcaggcc aacggctacc tgaattggta tcagcagcgg     1680

cgcggaaagg ctcccaaact gctgatctac gacggctcca agctggagcg cggagtgcct     1740

agccgattct ccgggcgaag gtggggacag gagtataacc tgactatcaa caatctgcag     1800

cctgaagata ttgccaccta cttctgccag gtgtatgagt ttgtcgtgcc agggaccagg     1860

ctggacctga agagaacagt cgcagccccc agcgtgttca tctttccacc ctcagatgag     1920

cagctgaaat ccggaaccgc ctctgtggtg tgcctgctga acaacttcta cccacgcgaa     1980

gccaaggtcc agtggaaagt ggacaacgct ctgcagtctg gcaatagtca ggagtcagtg     2040

acagaacagg acagcaagga ttccacttat tctctgagtt caaccctgac actgtccaaa     2100

gcagattacg agaagcacaa agtgtatgcc tgcgaggtca cccaccaggg gctgcggtca     2160

ccagtcacaa agtccttcaa cagaggggaa tgctgataac tcgag                     2205


<210>  3
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG1 antibody (heavy chain) (mod1)

<400>  3

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile 
        35                  40                  45              


Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro 
65                  70                  75                  80  


Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp 
                85                  90                  95      


Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp 
        115                 120                 125             


Phe Asp Val Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  4
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG1 antibody (heavy chain) (mod1)

<400>  4
ggatccgcca ccatggattg gacatggaga attctgtttc tggtcgccgc cgctaccgga       60

actcacgctc aggtgcagct gctgcagtca ggggccgcag tgacaaagcc aggggcaagt      120

gtccgcgtgt catgcgaggc cagcggctac aacatccggg actatttcat tcactggtgg      180

cgacaggcac ctggacaggg actgcagtgg gtggggtgga tcaatccaaa gaccggccag      240

cccaacaatc ctaggcagtt ccagggcaga gtgagcctga cccggcatgc ttcctgggac      300

tttgatacat tctcttttta catggacctg aaggcactga ggagtgacga taccgccgtg      360

tacttctgcg ctagacagcg gtcagattat tgggactttg acgtgtgggg cagcggaact      420

caggtcaccg tgagctccgc cagtacaaag ggaccttcag tgtttccact ggctccctct      480

agtaaaagca catccggcgg aactgccgct ctgggatgtc tggtgaagga ctacttccct      540

gagccagtca ccgtgtcctg gaactctgga gctctgacta gcggggtcca cacctttcca      600

gcagtgctgc agtcaagcgg cctgtactcc ctgtcctctg tggtcactgt ccccagttca      660

agcctgggaa ctcagaccta tatctgcaac gtgaatcaca agccaagtaa taccaaagtc      720

gacaagaaag tggagcccaa gtcctgtgat aaaacacata cttgccctcc ctgtccagct      780

cctgaactgc tgggcggccc aagcgtgttc ctgtttccac ccaagcctaa agacactctg      840

atgatttcta gaacccctga ggtcacatgc gtggtcgtgg acgtgagcca cgaggacccc      900

gaagtcaagt tcaactggta cgtggatggc gtcgaagtgc ataatgccaa gaccaaaccc      960

cgagaggaac agtacaactc tacttatagg gtcgtgagtg tcctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtataagtgc aaagtgtcca ataaggctct gccagcaccc     1080

atcgaaaaaa caatttctaa ggccaaagga cagcctagag agccacaggt gtacactctg     1140

cctccatccc gggacgaact gacaaagaac caggtctctc tgacttgtct ggtgaaagga     1200

ttctatccca gcgatatcgc tgtggagtgg gaatccaatg ggcagcctga gaacaattac     1260

aagaccacac cccctgtgct ggacagtgat gggtcattct ttctgtattc caagctgaca     1320

gtggacaaat ctcggtggca gcagggcaac gtcttttctt gcagtgtgat gcatgaagcc     1380

ctgcacaatc attacacaca gaagtcactg agcctgtccc caggaaagtg ataactcgag     1440


<210>  5
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG1 antibody (light chain) (mod1)

<400>  5

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr 
        35                  40                  45              


Leu Asn Trp Tyr Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile 
    50                  55                  60                  


Tyr Asp Gly Ser Lys Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly 
65                  70                  75                  80  


Arg Arg Trp Gly Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro 
                85                  90                  95      


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Val Tyr Glu Phe Val Val Pro 
            100                 105                 110         


Gly Thr Arg Leu Asp Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
    130                 135                 140                 


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
145                 150                 155                 160 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
                165                 170                 175     


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
            180                 185                 190         


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
        195                 200                 205             


Thr His Gln Gly Leu Arg Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
    210                 215                 220                 


Glu Cys 
225     


<210>  6
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG1 antibody (light chain) (mod1)

<400>  6
ggatccgcca ccatggtcct gcagacccag gtgtttatct cactgctgct gtggattagc       60

ggcgcatatg gagacatcca gatgacacag agcccttcct ctctgtcagc aagcgtcggc      120

gataccgtga caattacttg tcaggccaac ggctacctga attggtatca gcagcggcgc      180

ggaaaggctc ccaaactgct gatctacgac ggctccaagc tggagcgcgg agtgcctagc      240

cgattctccg ggcgaaggtg gggacaggag tataacctga ctatcaacaa tctgcagcct      300

gaagatattg ccacctactt ctgccaggtg tatgagtttg tcgtgccagg gaccaggctg      360

gacctgaaga gaacagtcgc agcccccagc gtgttcatct ttccaccctc agatgagcag      420

ctgaaatccg gaaccgcctc tgtggtgtgc ctgctgaaca acttctaccc acgcgaagcc      480

aaggtccagt ggaaagtgga caacgctctg cagtctggca atagtcagga gtcagtgaca      540

gaacaggaca gcaaggattc cacttattct ctgagttcaa ccctgacact gtccaaagca      600

gattacgaga agcacaaagt gtatgcctgc gaggtcaccc accaggggct gcggtcacca      660

gtcacaaagt ccttcaacag aggggaatgc tgataactcg ag                         702


<210>  7
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG4 (mod 2)

<400>  7

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile 
        35                  40                  45              


Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro 
65                  70                  75                  80  


Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp 
                85                  90                  95      


Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp 
        115                 120                 125             


Phe Asp Val Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
    210                 215                 220                 


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Leu Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala 
465                 470                 475                 480 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
                485                 490                 495     


Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp 
            500                 505                 510         


Ile Ser Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        515                 520                 525             


Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Gln Ala Asn 
    530                 535                 540                 


Gly Tyr Leu Asn Trp Tyr Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu 
545                 550                 555                 560 


Leu Ile Tyr Asp Gly Ser Lys Leu Glu Arg Gly Val Pro Ser Arg Phe 
                565                 570                 575     


Ser Gly Arg Arg Trp Gly Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu 
            580                 585                 590         


Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Val Tyr Glu Phe Val 
        595                 600                 605             


Val Pro Gly Thr Arg Leu Asp Leu Lys Arg Thr Val Ala Ala Pro Ser 
    610                 615                 620                 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
625                 630                 635                 640 


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
                645                 650                 655     


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
            660                 665                 670         


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn Thr 
        675                 680                 685             


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
    690                 695                 700                 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
705                 710                 715                 720 


Arg Gly Glu Cys 
                


<210>  8
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG4 (mod 2)

<400>  8
ggatccgcca ccatggactg gacctggcgc atcctgttcc tggtggcagc agcaaccgga       60

acacacgcac aggtgcagct gctgcagagc ggagcagcag tgacaaagcc aggagcatct      120

gtgagggtga gctgcgaggc atccggctac aacatccgcg attacttcat ccactggtgg      180

aggcaggcac caggacaggg actgcagtgg gtgggctgga tcaatcctaa gaccggccag      240

cctaacaatc caaggcagtt ccagggacgc gtgagcctga ccaggcacgc ctcctgggac      300

tttgatacat tctcttttta catggacctg aaggccctgc gcagcgacga taccgccgtg      360

tacttctgtg cccggcagag gagcgattat tgggactttg acgtgtgggg ctctggcacc      420

caggtgacag tgagctccgc ctccacaaag ggaccaagcg tgttcccact ggcaccttgc      480

agcaggtcca cctctgagag cacagccgcc ctgggctgtc tggtgaagga ctacttccct      540

gagccagtga ccgtgagctg gaactccggc gccctgacca gcggagtgca cacatttccc      600

gccgtgctgc agtctagcgg cctgtactcc ctgtcctctg tggtgaccgt gcctagctcc      660

tctctgggca ccaagacata tacctgcaac gtggaccaca agccaagcaa tacaaaggtg      720

gataagagag tggagtccaa gtacggccct ccctgccctt cttgtccagc acctgagttc      780

ctgggcggcc cttccgtgtt cctgtttcca cccaagccaa aggacaccct gatgatctct      840

cggacccccg aggtgacatg cgtggtggtg gacgtgagcc aggaggaccc cgaggtgcag      900

ttcaactggt acgtggatgg cgtggaggtg cacaatgcca agacaaagcc cagagaggag      960

cagtttaact ctacctaccg ggtggtgagc gtgctgacag tgctgcacca ggactggctg     1020

aacggcaagg agtataagtg caaggtgtcc aataagggcc tgcctagctc catcgagaag     1080

accatctcta aggcaaaggg acagccacgc gagccacagg tgtacacact gcctccaagc     1140

caggaggaga tgaccaagaa ccaggtgtcc ctgacatgtc tggtgaaggg cttctatcca     1200

agcgacatcg ccgtggagtg ggagtccaat ggccagcccg agaacaatta caagaccaca     1260

ccccctgtgc tggactctga tggcagcttc tttctgtata gcagactgac cgtggataag     1320

tcccggtggc aggagggcaa cgtgttttcc tgctctgtga tgcacgaggc cctgcacaat     1380

cactacaccc agaagagcct gtccctgtct ctgggcaaga ggggcagaaa gaggagaagc     1440

ggctccggcg ccacaaactt cagcctgctg aagcaggcag gcgacgtgga ggagaatcca     1500

ggacccatgg tgctgcagac ccaggtgttt atctccctgc tgctgtggat ctctggcgcc     1560

tatggcgaca tccagatgac acagtccccc tctagcctgt ctgccagcgt gggcgataca     1620

gtgaccatca catgtcaggc caacggctac ctgaattggt atcagcagag gaggggcaag     1680

gcaccaaagc tgctgatcta cgacggcagc aagctggaga gaggcgtgcc ctcccggttc     1740

tctggcagga gatggggcca ggagtataac ctgaccatca acaatctgca gcctgaggat     1800

atcgccacat acttctgcca ggtgtatgag tttgtggtgc ctggcacccg cctggacctg     1860

aagaggacag tggccgcccc aagcgtgttc atctttccac ccagcgatga gcagctgaag     1920

tctggcaccg ccagcgtggt gtgcctgctg aacaatttct acccaagaga ggccaaggtg     1980

cagtggaagg tggacaacgc cctgcagagc ggcaattccc aggagtctgt gaccgagcag     2040

gacagcaagg attccacata ttccctgtct aacaccctga cactgagcaa ggccgattac     2100

gagaagcaca aggtgtatgc atgcgaggtg acccaccagg gactgtcctc tcctgtgaca     2160

aagtccttta atcggggcga gtgttgataa ctcgag                               2196


<210>  9
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG4 (S228P) (mod 3)

<400>  9

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile 
        35                  40                  45              


Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro 
65                  70                  75                  80  


Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp 
                85                  90                  95      


Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp 
        115                 120                 125             


Phe Asp Val Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
    210                 215                 220                 


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Leu Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala 
465                 470                 475                 480 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
                485                 490                 495     


Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp 
            500                 505                 510         


Ile Ser Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        515                 520                 525             


Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Gln Ala Asn 
    530                 535                 540                 


Gly Tyr Leu Asn Trp Tyr Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu 
545                 550                 555                 560 


Leu Ile Tyr Asp Gly Ser Lys Leu Glu Arg Gly Val Pro Ser Arg Phe 
                565                 570                 575     


Ser Gly Arg Arg Trp Gly Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu 
            580                 585                 590         


Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Val Tyr Glu Phe Val 
        595                 600                 605             


Val Pro Gly Thr Arg Leu Asp Leu Lys Arg Thr Val Ala Ala Pro Ser 
    610                 615                 620                 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
625                 630                 635                 640 


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
                645                 650                 655     


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
            660                 665                 670         


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn Thr 
        675                 680                 685             


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
    690                 695                 700                 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
705                 710                 715                 720 


Arg Gly Glu Cys 
                


<210>  10
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG4 (S228P) (mod 3)

<400>  10
ggatccgcca ccatggactg gacctggcgc atcctgttcc tggtggcagc agcaaccgga       60

acacacgcac aggtgcagct gctgcagagc ggagcagcag tgacaaagcc aggagcatct      120

gtgagggtga gctgcgaggc atccggctac aacatccgcg attacttcat ccactggtgg      180

aggcaggcac caggacaggg actgcagtgg gtgggctgga tcaatcctaa gaccggccag      240

cctaacaatc caaggcagtt ccagggacgc gtgagcctga ccaggcacgc ctcctgggac      300

tttgatacat tctcttttta catggacctg aaggccctgc gcagcgacga taccgccgtg      360

tacttctgtg cccggcagag gagcgattat tgggactttg acgtgtgggg ctctggcacc      420

caggtgacag tgagctccgc ctccacaaag ggaccaagcg tgttcccact ggcaccttgc      480

agcaggtcca cctctgagag cacagccgcc ctgggctgtc tggtgaagga ctacttccct      540

gagccagtga ccgtgagctg gaactccggc gccctgacca gcggagtgca cacatttccc      600

gccgtgctgc agtctagcgg cctgtactcc ctgtcctctg tggtgaccgt gcctagctcc      660

tctctgggca ccaagacata tacctgcaac gtggaccaca agccaagcaa tacaaaggtg      720

gataagagag tggagtccaa gtacggccct ccctgccctc cctgtccagc acctgagttc      780

ctgggcggcc cttccgtgtt cctgtttcca cccaagccaa aggacaccct gatgatctct      840

cggacccccg aggtgacatg cgtggtggtg gacgtgagcc aggaggaccc cgaggtgcag      900

ttcaactggt acgtggatgg cgtggaggtg cacaatgcca agacaaagcc cagagaggag      960

cagtttaact ctacctaccg ggtggtgagc gtgctgacag tgctgcacca ggactggctg     1020

aacggcaagg agtataagtg caaggtgtcc aataagggcc tgcctagctc catcgagaag     1080

accatctcta aggcaaaggg acagccacgc gagccacagg tgtacacact gcctccaagc     1140

caggaggaga tgaccaagaa ccaggtgtcc ctgacatgtc tggtgaaggg cttctatcca     1200

agcgacatcg ccgtggagtg ggagtccaat ggccagcccg agaacaatta caagaccaca     1260

ccccctgtgc tggactctga tggcagcttc tttctgtata gcagactgac cgtggataag     1320

tcccggtggc aggagggcaa cgtgttttcc tgctctgtga tgcacgaggc cctgcacaat     1380

cactacaccc agaagagcct gtccctgtct ctgggcaaga ggggcagaaa gaggagaagc     1440

ggctccggcg ccacaaactt cagcctgctg aagcaggcag gcgacgtgga ggagaatcca     1500

ggacccatgg tgctgcagac ccaggtgttt atctccctgc tgctgtggat ctctggcgcc     1560

tatggcgaca tccagatgac acagtccccc tctagcctgt ctgccagcgt gggcgataca     1620

gtgaccatca catgtcaggc caacggctac ctgaattggt atcagcagag gaggggcaag     1680

gcaccaaagc tgctgatcta cgacggcagc aagctggaga gaggcgtgcc ctcccggttc     1740

tctggcagga gatggggcca ggagtataac ctgaccatca acaatctgca gcctgaggat     1800

atcgccacat acttctgcca ggtgtatgag tttgtggtgc ctggcacccg cctggacctg     1860

aagaggacag tggccgcccc aagcgtgttc atctttccac ccagcgatga gcagctgaag     1920

tctggcaccg ccagcgtggt gtgcctgctg aacaatttct acccaagaga ggccaaggtg     1980

cagtggaagg tggacaacgc cctgcagagc ggcaattccc aggagtctgt gaccgagcag     2040

gacagcaagg attccacata ttccctgtct aacaccctga cactgagcaa ggccgattac     2100

gagaagcaca aggtgtatgc atgcgaggtg acccaccagg gactgtcctc tcctgtgaca     2160

aagtccttta atcggggcga gtgttgataa ctcgag                               2196


<210>  11
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG4 (heavy chain) (mod 4)

<400>  11

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile 
        35                  40                  45              


Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro 
65                  70                  75                  80  


Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp 
                85                  90                  95      


Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp 
        115                 120                 125             


Phe Asp Val Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
    210                 215                 220                 


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Leu Gly Lys 
465                 


<210>  12
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG4 (heavy chain) (mod 4)

<400>  12
ggatccgcca ccatggactg gacctggcgc atcctgttcc tggtggcagc agcaaccgga       60

acacacgcac aggtgcagct gctgcagagc ggagcagcag tgacaaagcc aggagcatct      120

gtgagggtga gctgcgaggc atccggctac aacatccgcg attacttcat ccactggtgg      180

aggcaggcac caggacaggg actgcagtgg gtgggctgga tcaatcctaa gaccggccag      240

cctaacaatc caaggcagtt ccagggacgc gtgagcctga ccaggcacgc ctcctgggac      300

tttgatacat tctcttttta catggacctg aaggccctgc gcagcgacga taccgccgtg      360

tacttctgtg cccggcagag gagcgattat tgggactttg acgtgtgggg ctctggcacc      420

caggtgacag tgagctccgc ctccacaaag ggaccaagcg tgttcccact ggcaccttgc      480

agcaggtcca cctctgagag cacagccgcc ctgggctgtc tggtgaagga ctacttccct      540

gagccagtga ccgtgagctg gaactccggc gccctgacca gcggagtgca cacatttccc      600

gccgtgctgc agtctagcgg cctgtactcc ctgtcctctg tggtgaccgt gcctagctcc      660

tctctgggca ccaagacata tacctgcaac gtggaccaca agccaagcaa tacaaaggtg      720

gataagagag tggagtccaa gtacggccct ccctgccctc cctgtccagc acctgagttc      780

ctgggcggcc cttccgtgtt cctgtttcca cccaagccaa aggacaccct gatgatctct      840

cggacccccg aggtgacatg cgtggtggtg gacgtgagcc aggaggaccc cgaggtgcag      900

ttcaactggt acgtggatgg cgtggaggtg cacaatgcca agacaaagcc cagagaggag      960

cagtttaact ctacctaccg ggtggtgagc gtgctgacag tgctgcacca ggactggctg     1020

aacggcaagg agtataagtg caaggtgtcc aataagggcc tgcctagctc catcgagaag     1080

accatctcta aggcaaaggg acagccacgc gagccacagg tgtacacact gcctccaagc     1140

caggaggaga tgaccaagaa ccaggtgtcc ctgacatgtc tggtgaaggg cttctatcca     1200

agcgacatcg ccgtggagtg ggagtccaat ggccagcccg agaacaatta caagaccaca     1260

ccccctgtgc tggactctga tggcagcttc tttctgtata gcagactgac cgtggataag     1320

tcccggtggc aggagggcaa cgtgttttcc tgctctgtga tgcacgaggc cctgcacaat     1380

cactacaccc agaagagcct gtccctgtct ctgggcaagt gataactcga g              1431


<210>  13
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG4 (light chain)(mod 4)

<400>  13

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr 
        35                  40                  45              


Leu Asn Trp Tyr Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile 
    50                  55                  60                  


Tyr Asp Gly Ser Lys Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly 
65                  70                  75                  80  


Arg Arg Trp Gly Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro 
                85                  90                  95      


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Val Tyr Glu Phe Val Val Pro 
            100                 105                 110         


Gly Thr Arg Leu Asp Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
    130                 135                 140                 


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
145                 150                 155                 160 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
                165                 170                 175     


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
        195                 200                 205             


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
    210                 215                 220                 


Glu Cys 
225     


<210>  14
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 human IgG4 (light chain)(mod 4)

<400>  14
ggatccgcca ccatggtgct gcagacccag gtgtttatct ccctgctgct gtggatctct       60

ggcgcctatg gcgacatcca gatgacacag tccccctcta gcctgtctgc cagcgtgggc      120

gatacagtga ccatcacatg tcaggccaac ggctacctga attggtatca gcagaggagg      180

ggcaaggcac caaagctgct gatctacgac ggcagcaagc tggagagagg cgtgccctcc      240

cggttctctg gcaggagatg gggccaggag tataacctga ccatcaacaa tctgcagcct      300

gaggatatcg ccacatactt ctgccaggtg tatgagtttg tggtgcctgg cacccgcctg      360

gacctgaaga ggacagtggc cgccccaagc gtgttcatct ttccacccag cgatgagcag      420

ctgaagtctg gcaccgccag cgtggtgtgc ctgctgaaca atttctaccc aagagaggcc      480

aaggtgcagt ggaaggtgga caacgccctg cagagcggca attcccagga gtctgtgacc      540

gagcaggaca gcaaggattc cacatattcc ctgtctaaca ccctgacact gagcaaggcc      600

gattacgaga agcacaaggt gtatgcatgc gaggtgaccc accagggact gtcctctcct      660

gtgacaaagt cctttaatcg gggcgagtgt tgataactcg ag                         702


<210>  15
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT128 Human IgG1

<400>  15

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Pro Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Glu 
            20                  25                  30          


Ala Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Thr 
        35                  40                  45              


Ala Ala Cys Asn Ser Phe Trp Gly Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Gly Ser Leu Ser His Cys Ala Ser Tyr Trp Asn 
65                  70                  75                  80  


Arg Gly Trp Thr Tyr His Asn Pro Ser Leu Lys Ser Arg Leu Thr Leu 
                85                  90                  95      


Ala Leu Asp Thr Pro Lys Asn Leu Val Phe Leu Lys Leu Asn Ser Val 
            100                 105                 110         


Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Phe Gly Gly Glu 
        115                 120                 125             


Val Leu Arg Tyr Thr Asp Trp Pro Lys Pro Ala Trp Val Asp Leu Trp 
    130                 135                 140                 


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr 
                485                 490                 495     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro 
        515                 520                 525             


Gly Gly Ser Asn Ser Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser 
    530                 535                 540                 


Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn 
545                 550                 555                 560 


Asn Phe Val Ser Trp Tyr Gln Gln His Ala Gly Lys Ala Pro Lys Leu 
                565                 570                 575     


Val Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
            580                 585                 590         


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
        595                 600                 605             


Gln Thr Asp Asp Glu Ala Val Tyr Tyr Cys Gly Ser Leu Val Gly Asn 
    610                 615                 620                 


Trp Asp Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
625                 630                 635                 640 


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
                645                 650                 655     


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            660                 665                 670         


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
        675                 680                 685             


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    690                 695                 700                 


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
705                 710                 715                 720 


Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                725                 730                 735     


Thr Val Ala Pro Thr Glu Cys Ser 
            740                 


<210>  16
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT128 Human IgG1

<400>  16
ggatccgcca ccatggactg gacctggaga atcctgttcc tggtggcagc agcaacagga       60

acccacgcac agccacagct gcaggagtcc ggacccaccc tggtggaggc ctccgagaca      120

ctgtctctga cctgcgccgt gagcggcgat tccacagcag cctgtaactc cttctgggga      180

tgggtgcgcc agccccctgg caagggcctg gagtgggtgg gctctctgag ccactgcgcc      240

agctactgga acaggggctg gacctatcac aatccctctc tgaagagcag actgaccctg      300

gccctggaca cacctaagaa cctggtgttc ctgaagctga atagcgtgac cgccgccgat      360

acagccacct actattgtgc caggtttggc ggcgaggtgc tgagatacac agactggcca      420

aagccagcat gggtggatct gtggggaagg ggcacactgg tgaccgtgag ctccgcctcc      480

accaagggac caagcgtgtt cccactggca ccttctagca agtccacatc tggcggcacc      540

gccgccctgg gatgcctggt gaaggactac ttccctgagc cagtgacagt gtcctggaac      600

tctggcgccc tgacctctgg cgtgcacaca tttcccgccg tgctgcagtc ctctggcctg      660

tacagcctga gctccgtggt gaccgtgcct tctagctccc tgggcacaca gacctatatc      720

tgcaacgtga atcacaagcc tagcaataca aaggtggaca agaaggtgga gccaaagtcc      780

tgtgataaga cacacacctg cccaccctgt ccagcacctg agctgctggg cggcccttcc      840

gtgttcctgt ttcctccaaa gccaaaggac accctgatga tctcccggac acctgaggtg      900

acctgcgtgg tggtggacgt gtctcacgag gaccccgagg tgaagtttaa ctggtacgtg      960

gatggcgtgg aggtgcacaa tgccaagacc aagcccaggg aggagcagta caactctacc     1020

tatagagtgg tgagcgtgct gacagtgctg caccaggatt ggctgaacgg caaggagtat     1080

aagtgcaagg tgagcaataa ggccctgcca gcccccatcg agaagaccat ctccaaggca     1140

aagggacagc cacgggagcc acaggtgtac acactgcccc cttcccgcga cgagctgacc     1200

aagaaccagg tgtctctgac atgtctggtg aagggcttct atccaagcga tatcgccgtg     1260

gagtgggagt ccaatggcca gcccgagaac aattacaaga ccacaccacc cgtgctggac     1320

agcgatggct ccttctttct gtattccaag ctgaccgtgg acaagtctag gtggcagcag     1380

ggcaacgtgt ttagctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag     1440

tctctgagcc tgtcccctgg caagagggga aggaagagga gatctggcag cggcgccaca     1500

aacttcagcc tgctgaagca ggccggcgat gtggaggaga atcctggccc aatggcctgg     1560

acccctctgt tcctgttcct gctgacatgc tgtcctggcg gctccaactc tcagagcgcc     1620

ctgacccagc ctccatccgc ctctggcagc cctggacaga gcatcacaat ctcctgtaca     1680

ggcaccagca acaatttcgt gagctggtac cagcagcacg caggcaaggc accaaagctg     1740

gtcatctacg acgtgaacaa gcggccttcc ggcgtgccag atcgcttctc cggctctaag     1800

agcggcaata cagcctctct gaccgtgagc ggcctgcaga ccgacgatga ggccgtgtac     1860

tattgcggca gcctggtggg caactgggac gtgatcttcg gcggcggaac aaagctgacc     1920

gtgctgggac agccaaaggc agcaccttcc gtgaccctgt ttcccccttc tagcgaggag     1980

ctgcaggcca ataaggccac cctggtgtgc ctgatcagcg acttctaccc tggagcagtg     2040

acagtggcat ggaaggccga ttcctctcca gtgaaggccg gcgtggagac cacaaccccc     2100

tctaagcaga gcaacaataa gtacgccgcc agctcctatc tgtctctgac cccagagcag     2160

tggaagagcc acaagtccta ttcttgccag gtgacacacg agggctctac agtggagaag     2220

accgtggccc ccacagagtg tagctgataa ctcgag                               2256


<210>  17
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT128 HUMAN IgG1- (HEAVY CHAIN) (MOD 1)

<400>  17

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Pro Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Glu 
            20                  25                  30          


Ala Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Thr 
        35                  40                  45              


Ala Ala Cys Asn Ser Phe Trp Gly Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Gly Ser Leu Ser His Cys Ala Ser Tyr Trp Asn 
65                  70                  75                  80  


Arg Gly Trp Thr Tyr His Asn Pro Ser Leu Lys Ser Arg Leu Thr Leu 
                85                  90                  95      


Ala Leu Asp Thr Pro Lys Asn Leu Val Phe Leu Lys Leu Asn Ser Val 
            100                 105                 110         


Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Phe Gly Gly Glu 
        115                 120                 125             


Val Leu Arg Tyr Thr Asp Trp Pro Lys Pro Ala Trp Val Asp Leu Trp 
    130                 135                 140                 


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Lys 
                


<210>  18
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT128 HUMAN IgG1- (HEAVY CHAIN) (MOD 1)

<400>  18
ggatccgcca ccatggactg gacctggaga atcctgttcc tggtggcagc agcaacagga       60

acccacgcac agccacagct gcaggagtcc ggacccaccc tggtggaggc ctccgagaca      120

ctgtctctga cctgcgccgt gagcggcgat tccacagcag cctgtaactc cttctgggga      180

tgggtgcgcc agccccctgg caagggcctg gagtgggtgg gctctctgag ccactgcgcc      240

agctactgga acaggggctg gacctatcac aatccctctc tgaagagcag actgaccctg      300

gccctggaca cacctaagaa cctggtgttc ctgaagctga atagcgtgac cgccgccgat      360

acagccacct actattgtgc caggtttggc ggcgaggtgc tgagatacac agactggcca      420

aagccagcat gggtggatct gtggggaagg ggcacactgg tgaccgtgag ctccgcctcc      480

accaagggac caagcgtgtt cccactggca ccttctagca agtccacatc tggcggcacc      540

gccgccctgg gatgcctggt gaaggactac ttccctgagc cagtgacagt gtcctggaac      600

tctggcgccc tgacctctgg cgtgcacaca tttcccgccg tgctgcagtc ctctggcctg      660

tacagcctga gctccgtggt gaccgtgcct tctagctccc tgggcacaca gacctatatc      720

tgcaacgtga atcacaagcc tagcaataca aaggtggaca agaaggtgga gccaaagtcc      780

tgtgataaga cacacacctg cccaccctgt ccagcacctg agctgctggg cggcccttcc      840

gtgttcctgt ttcctccaaa gccaaaggac accctgatga tctcccggac acctgaggtg      900

acctgcgtgg tggtggacgt gtctcacgag gaccccgagg tgaagtttaa ctggtacgtg      960

gatggcgtgg aggtgcacaa tgccaagacc aagcccaggg aggagcagta caactctacc     1020

tatagagtgg tgagcgtgct gacagtgctg caccaggatt ggctgaacgg caaggagtat     1080

aagtgcaagg tgagcaataa ggccctgcca gcccccatcg agaagaccat ctccaaggca     1140

aagggacagc cacgggagcc acaggtgtac acactgcccc cttcccgcga cgagctgacc     1200

aagaaccagg tgtctctgac atgtctggtg aagggcttct atccaagcga tatcgccgtg     1260

gagtgggagt ccaatggcca gcccgagaac aattacaaga ccacaccacc cgtgctggac     1320

agcgatggct ccttctttct gtattccaag ctgaccgtgg acaagtctag gtggcagcag     1380

ggcaacgtgt ttagctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag     1440

tctctgagcc tgtcccctgg caagtgataa ctcgag                               1476


<210>  19
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT128 human IgG1- (light chain) (mod 1)

<400>  19

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly 
            20                  25                  30          


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asn 
        35                  40                  45              


Phe Val Ser Trp Tyr Gln Gln His Ala Gly Lys Ala Pro Lys Leu Val 
    50                  55                  60                  


Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
65                  70                  75                  80  


Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln 
                85                  90                  95      


Thr Asp Asp Glu Ala Val Tyr Tyr Cys Gly Ser Leu Val Gly Asn Trp 
            100                 105                 110         


Asp Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
        115                 120                 125             


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
    130                 135                 140                 


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
145                 150                 155                 160 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
                165                 170                 175     


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
            180                 185                 190         


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys 
        195                 200                 205             


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
    210                 215                 220                 


Val Ala Pro Thr Glu Cys Ser 
225                 230     


<210>  20
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT128 human IgG1- (light chain) (mod 1)

<400>  20
ggatccgcca ccatggcctg gacccctctg ttcctgttcc tgctgacatg ctgtcctggc       60

ggctccaact ctcagagcgc cctgacccag cctccatccg cctctggcag ccctggacag      120

agcatcacaa tctcctgtac aggcaccagc aacaatttcg tgagctggta ccagcagcac      180

gcaggcaagg caccaaagct ggtcatctac gacgtgaaca agcggccttc cggcgtgcca      240

gatcgcttct ccggctctaa gagcggcaat acagcctctc tgaccgtgag cggcctgcag      300

accgacgatg aggccgtgta ctattgcggc agcctggtgg gcaactggga cgtgatcttc      360

ggcggcggaa caaagctgac cgtgctggga cagccaaagg cagcaccttc cgtgaccctg      420

tttccccctt ctagcgagga gctgcaggcc aataaggcca ccctggtgtg cctgatcagc      480

gacttctacc ctggagcagt gacagtggca tggaaggccg attcctctcc agtgaaggcc      540

ggcgtggaga ccacaacccc ctctaagcag agcaacaata agtacgccgc cagctcctat      600

ctgtctctga ccccagagca gtggaagagc cacaagtcct attcttgcca ggtgacacac      660

gagggctcta cagtggagaa gaccgtggcc cccacagagt gtagctgata actcgag         717


<210>  21
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT128 human IgG4 (mod 2)

<400>  21

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Pro Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Glu 
            20                  25                  30          


Ala Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Thr 
        35                  40                  45              


Ala Ala Cys Asn Ser Phe Trp Gly Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Gly Ser Leu Ser His Cys Ala Ser Tyr Trp Asn 
65                  70                  75                  80  


Arg Gly Trp Thr Tyr His Asn Pro Ser Leu Lys Ser Arg Leu Thr Leu 
                85                  90                  95      


Ala Leu Asp Thr Pro Lys Asn Leu Val Phe Leu Lys Leu Asn Ser Val 
            100                 105                 110         


Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Phe Gly Gly Glu 
        115                 120                 125             


Val Leu Arg Tyr Thr Asp Trp Pro Lys Pro Ala Trp Val Asp Leu Trp 
    130                 135                 140                 


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
                245                 250                 255     


Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
    290                 295                 300                 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
465                 470                 475                 480 


Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
                485                 490                 495     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
            500                 505                 510         


Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly Gly Ser 
        515                 520                 525             


Asn Ser Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro 
    530                 535                 540                 


Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asn Phe Val 
545                 550                 555                 560 


Ser Trp Tyr Gln Gln His Ala Gly Lys Ala Pro Lys Leu Val Ile Tyr 
                565                 570                 575     


Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
            580                 585                 590         


Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln Thr Asp 
        595                 600                 605             


Asp Glu Ala Val Tyr Tyr Cys Gly Ser Leu Val Gly Asn Trp Asp Val 
    610                 615                 620                 


Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
625                 630                 635                 640 


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
                645                 650                 655     


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
            660                 665                 670         


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
        675                 680                 685             


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
    690                 695                 700                 


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr 
705                 710                 715                 720 


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
                725                 730                 735     


Pro Thr Glu Cys Ser 
            740     


<210>  22
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT128 human IgG4 (mod 2)

<400>  22
ggatccgcca ccatggactg gacctggaga atcctgttcc tggtggcagc agcaacagga       60

acccacgcac agccccagct gcaggagtcc ggccctacac tggtggaggc cagcgagacc      120

ctgtccctga catgcgccgt gtctggcgat agcaccgcag catgtaactc cttctgggga      180

tgggtgcgcc agccccctgg caagggcctg gagtgggtgg gctctctgag ccactgcgcc      240

agctactgga acaggggctg gacctatcac aatccatccc tgaagtctag actgacactg      300

gccctggaca cccccaagaa cctggtgttc ctgaagctga atagcgtgac agccgccgat      360

acagccacct actattgtgc caggtttggc ggcgaggtgc tgagatacac cgactggcca      420

aagccagcat gggtggatct gtggggaagg ggcaccctgg tgacagtgag ctccgccagc      480

acaaagggcc cttccgtgtt tcctctggcc ccatgctccc gctctaccag cgagtccaca      540

gccgccctgg gatgtctggt gaaggactat ttccctgagc cagtgaccgt gagctggaac      600

tccggcgccc tgacatccgg agtgcacacc tttccagccg tgctgcagtc tagcggcctg      660

tactctctgt cctctgtggt gacagtgcca agctcctctc tgggcacaaa gacctataca      720

tgcaacgtgg accacaagcc ctccaatacc aaggtggata agagggtgga gtctaagtac      780

ggcccaccct gcccaagctg tccagcacct gagttcctgg gcggcccaag cgtgttcctg      840

tttcctccaa agcccaagga caccctgatg atcagcagaa cccccgaggt gacatgcgtg      900

gtggtggacg tgtcccagga ggaccccgag gtgcagttca actggtacgt ggatggcgtg      960

gaggtgcaca atgccaagac caagccacgg gaggagcagt ttaattccac ataccgcgtg     1020

gtgtctgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaggagta taagtgcaag     1080

gtgtctaata agggcctgcc cagctccatc gagaagacaa tcagcaaggc aaagggacag     1140

ccccgggagc ctcaggtgta caccctgccc ccttctcagg aggagatgac aaagaaccag     1200

gtgagcctga cctgtctggt gaagggcttc tatccttccg acatcgccgt ggagtgggag     1260

tctaatggcc agccagagaa caattacaag accacaccac ccgtgctgga ctctgatggc     1320

agcttctttc tgtatagccg gctgaccgtg gataagtccc gctggcagga gggcaacgtg     1380

ttttcttgca gcgtgatgca cgaggccctg cacaatcact acacacagaa gtccctgtct     1440

ctgagcctgg gcaagagggg aaggaagagg agatccggct ctggcgccac caacttcagc     1500

ctgctgaagc aggcaggcga cgtggaggag aatccaggac ccatggcctg gacacctctg     1560

ttcctgtttc tgctgacctg ctgtccaggc ggcagcaact cccagtctgc cctgacacag     1620

cctccaagcg cctccggctc tccaggacag tctatcacca tcagctgtac cggcacatct     1680

aacaattttg tgagctggta ccagcagcac gcaggcaagg cacctaagct ggtcatctac     1740

gacgtgaaca agaggccatc cggcgtgccc gatagattca gcggctccaa gtctggcaat     1800

accgcctccc tgacagtgtc tggcctgcag acagacgatg aggccgtgta ctattgcggc     1860

agcctggtgg gcaactggga tgtgatcttc ggcggcggaa ccaagctgac agtgctggga     1920

cagcctaagg cagcaccatc cgtgaccctg tttccccctt ctagcgagga gctgcaggcc     1980

aataaggcca ccctggtgtg cctgatcagc gacttctacc ctggagcagt gaccgtggca     2040

tggaaggccg attcctctcc cgtgaaggcc ggcgtggaga ccacaacccc ttccaagcag     2100

tctaacaata agtacgccgc cagctcctat ctgagcctga cacctgagca gtggaagtcc     2160

cacaagagct attcctgcca ggtgacccac gagggctcca ccgtggagaa gacagtggcc     2220

ccaaccgagt gttcttgata actcgag                                         2247


<210>  23
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT128 human IgG4mut (S228P) (mod3)

<400>  23

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Pro Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Glu 
            20                  25                  30          


Ala Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Thr 
        35                  40                  45              


Ala Ala Cys Asn Ser Phe Trp Gly Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Gly Ser Leu Ser His Cys Ala Ser Tyr Trp Asn 
65                  70                  75                  80  


Arg Gly Trp Thr Tyr His Asn Pro Ser Leu Lys Ser Arg Leu Thr Leu 
                85                  90                  95      


Ala Leu Asp Thr Pro Lys Asn Leu Val Phe Leu Lys Leu Asn Ser Val 
            100                 105                 110         


Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Phe Gly Gly Glu 
        115                 120                 125             


Val Leu Arg Tyr Thr Asp Trp Pro Lys Pro Ala Trp Val Asp Leu Trp 
    130                 135                 140                 


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
                245                 250                 255     


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
    290                 295                 300                 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
465                 470                 475                 480 


Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
                485                 490                 495     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
            500                 505                 510         


Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly Gly Ser 
        515                 520                 525             


Asn Ser Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro 
    530                 535                 540                 


Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asn Phe Val 
545                 550                 555                 560 


Ser Trp Tyr Gln Gln His Ala Gly Lys Ala Pro Lys Leu Val Ile Tyr 
                565                 570                 575     


Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
            580                 585                 590         


Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln Thr Asp 
        595                 600                 605             


Asp Glu Ala Val Tyr Tyr Cys Gly Ser Leu Val Gly Asn Trp Asp Val 
    610                 615                 620                 


Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
625                 630                 635                 640 


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
                645                 650                 655     


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
            660                 665                 670         


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
        675                 680                 685             


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
    690                 695                 700                 


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr 
705                 710                 715                 720 


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
                725                 730                 735     


Pro Thr Glu Cys Ser 
            740     


<210>  24
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT128 human IgG4mut (S228P) (mod3)

<400>  24
ggatccgcca ccatggactg gacctggaga atcctgttcc tggtggcagc agcaacagga       60

acccacgcac agccccagct gcaggagtcc ggccctacac tggtggaggc cagcgagacc      120

ctgtccctga catgcgccgt gtctggcgat agcaccgcag catgtaactc cttctgggga      180

tgggtgcgcc agccccctgg caagggcctg gagtgggtgg gctctctgag ccactgcgcc      240

agctactgga acaggggctg gacctatcac aatccatccc tgaagtctag actgacactg      300

gccctggaca cccccaagaa cctggtgttc ctgaagctga atagcgtgac agccgccgat      360

acagccacct actattgtgc caggtttggc ggcgaggtgc tgagatacac cgactggcca      420

aagccagcat gggtggatct gtggggaagg ggcaccctgg tgacagtgag ctccgccagc      480

acaaagggcc cttccgtgtt tcctctggcc ccatgctccc gctctaccag cgagtccaca      540

gccgccctgg gatgtctggt gaaggactat ttccctgagc cagtgaccgt gagctggaac      600

tccggcgccc tgacatccgg agtgcacacc tttccagccg tgctgcagtc tagcggcctg      660

tactctctgt cctctgtggt gacagtgcca agctcctctc tgggcacaaa gacctataca      720

tgcaacgtgg accacaagcc ctccaatacc aaggtggata agagggtgga gtctaagtac      780

ggcccaccct gcccaccctg tccagcacct gagttcctgg gcggcccaag cgtgttcctg      840

tttcctccaa agcccaagga caccctgatg atcagcagaa cccccgaggt gacatgcgtg      900

gtggtggacg tgtcccagga ggaccccgag gtgcagttca actggtacgt ggatggcgtg      960

gaggtgcaca atgccaagac caagccacgg gaggagcagt ttaattccac ataccgcgtg     1020

gtgtctgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaggagta taagtgcaag     1080

gtgtctaata agggcctgcc cagctccatc gagaagacaa tcagcaaggc aaagggacag     1140

ccccgggagc ctcaggtgta caccctgccc ccttctcagg aggagatgac aaagaaccag     1200

gtgagcctga cctgtctggt gaagggcttc tatccttccg acatcgccgt ggagtgggag     1260

tctaatggcc agccagagaa caattacaag accacaccac ccgtgctgga ctctgatggc     1320

agcttctttc tgtatagccg gctgaccgtg gataagtccc gctggcagga gggcaacgtg     1380

ttttcttgca gcgtgatgca cgaggccctg cacaatcact acacacagaa gtccctgtct     1440

ctgagcctgg gcaagagggg aaggaagagg agatccggct ctggcgccac caacttcagc     1500

ctgctgaagc aggcaggcga cgtggaggag aatccaggac ccatggcctg gacacctctg     1560

ttcctgtttc tgctgacctg ctgtccaggc ggcagcaact cccagtctgc cctgacacag     1620

cctccaagcg cctccggctc tccaggacag tctatcacca tcagctgtac cggcacatct     1680

aacaattttg tgagctggta ccagcagcac gcaggcaagg cacctaagct ggtcatctac     1740

gacgtgaaca agaggccatc cggcgtgccc gatagattca gcggctccaa gtctggcaat     1800

accgcctccc tgacagtgtc tggcctgcag acagacgatg aggccgtgta ctattgcggc     1860

agcctggtgg gcaactggga tgtgatcttc ggcggcggaa ccaagctgac agtgctggga     1920

cagcctaagg cagcaccatc cgtgaccctg tttccccctt ctagcgagga gctgcaggcc     1980

aataaggcca ccctggtgtg cctgatcagc gacttctacc ctggagcagt gaccgtggca     2040

tggaaggccg attcctctcc cgtgaaggcc ggcgtggaga ccacaacccc ttccaagcag     2100

tctaacaata agtacgccgc cagctcctat ctgagcctga cacctgagca gtggaagtcc     2160

cacaagagct attcctgcca ggtgacccac gagggctcca ccgtggagaa gacagtggcc     2220

ccaaccgagt gttcttgata actcgag                                         2247


<210>  25
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT128 human IgG4-heavy chain (mod 4)

<400>  25

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Pro Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Glu 
            20                  25                  30          


Ala Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Thr 
        35                  40                  45              


Ala Ala Cys Asn Ser Phe Trp Gly Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Gly Ser Leu Ser His Cys Ala Ser Tyr Trp Asn 
65                  70                  75                  80  


Arg Gly Trp Thr Tyr His Asn Pro Ser Leu Lys Ser Arg Leu Thr Leu 
                85                  90                  95      


Ala Leu Asp Thr Pro Lys Asn Leu Val Phe Leu Lys Leu Asn Ser Val 
            100                 105                 110         


Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Phe Gly Gly Glu 
        115                 120                 125             


Val Leu Arg Tyr Thr Asp Trp Pro Lys Pro Ala Trp Val Asp Leu Trp 
    130                 135                 140                 


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
                245                 250                 255     


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
    290                 295                 300                 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
465                 470                 475                 480 


Lys 
    


<210>  26
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT128 human IgG4-heavy chain (mod 4)

<400>  26
ggatccgcca ccatggactg gacctggaga atcctgttcc tggtggcagc agcaacagga       60

acccacgcac agccccagct gcaggagtcc ggccctacac tggtggaggc cagcgagacc      120

ctgtccctga catgcgccgt gtctggcgat agcaccgcag catgtaactc cttctgggga      180

tgggtgcgcc agccccctgg caagggcctg gagtgggtgg gctctctgag ccactgcgcc      240

agctactgga acaggggctg gacctatcac aatccatccc tgaagtctag actgacactg      300

gccctggaca cccccaagaa cctggtgttc ctgaagctga atagcgtgac agccgccgat      360

acagccacct actattgtgc caggtttggc ggcgaggtgc tgagatacac cgactggcca      420

aagccagcat gggtggatct gtggggaagg ggcaccctgg tgacagtgag ctccgccagc      480

acaaagggcc cttccgtgtt tcctctggcc ccatgctccc gctctaccag cgagtccaca      540

gccgccctgg gatgtctggt gaaggactat ttccctgagc cagtgaccgt gagctggaac      600

tccggcgccc tgacatccgg agtgcacacc tttccagccg tgctgcagtc tagcggcctg      660

tactctctgt cctctgtggt gacagtgcca agctcctctc tgggcacaaa gacctataca      720

tgcaacgtgg accacaagcc ctccaatacc aaggtggata agagggtgga gtctaagtac      780

ggcccaccct gcccaccctg tccagcacct gagttcctgg gcggcccaag cgtgttcctg      840

tttcctccaa agcccaagga caccctgatg atcagcagaa cccccgaggt gacatgcgtg      900

gtggtggacg tgtcccagga ggaccccgag gtgcagttca actggtacgt ggatggcgtg      960

gaggtgcaca atgccaagac caagccacgg gaggagcagt ttaattccac ataccgcgtg     1020

gtgtctgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaggagta taagtgcaag     1080

gtgtctaata agggcctgcc cagctccatc gagaagacaa tcagcaaggc aaagggacag     1140

ccccgggagc ctcaggtgta caccctgccc ccttctcagg aggagatgac aaagaaccag     1200

gtgagcctga cctgtctggt gaagggcttc tatccttccg acatcgccgt ggagtgggag     1260

tctaatggcc agccagagaa caattacaag accacaccac ccgtgctgga ctctgatggc     1320

agcttctttc tgtatagccg gctgaccgtg gataagtccc gctggcagga gggcaacgtg     1380

ttttcttgca gcgtgatgca cgaggccctg cacaatcact acacacagaa gtccctgtct     1440

ctgagcctgg gcaagtgata actcgag                                         1467


<210>  27
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT128 human IgG4-light chain (mod 4)

<400>  27

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly 
            20                  25                  30          


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asn 
        35                  40                  45              


Phe Val Ser Trp Tyr Gln Gln His Ala Gly Lys Ala Pro Lys Leu Val 
    50                  55                  60                  


Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
65                  70                  75                  80  


Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln 
                85                  90                  95      


Thr Asp Asp Glu Ala Val Tyr Tyr Cys Gly Ser Leu Val Gly Asn Trp 
            100                 105                 110         


Asp Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
        115                 120                 125             


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
    130                 135                 140                 


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
145                 150                 155                 160 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
                165                 170                 175     


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
            180                 185                 190         


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys 
        195                 200                 205             


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
    210                 215                 220                 


Val Ala Pro Thr Glu Cys Ser 
225                 230     


<210>  28
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT128 human IgG4-light chain (mod 4)

<400>  28
ggatccgcca ccatggcctg gacacctctg ttcctgtttc tgctgacctg ctgtccaggc       60

ggcagcaact cccagtctgc cctgacacag cctccaagcg cctccggctc tccaggacag      120

tctatcacca tcagctgtac cggcacatct aacaattttg tgagctggta ccagcagcac      180

gcaggcaagg cacctaagct ggtcatctac gacgtgaaca agaggccatc cggcgtgccc      240

gatagattca gcggctccaa gtctggcaat accgcctccc tgacagtgtc tggcctgcag      300

acagacgatg aggccgtgta ctattgcggc agcctggtgg gcaactggga tgtgatcttc      360

ggcggcggaa ccaagctgac agtgctggga cagcctaagg cagcaccatc cgtgaccctg      420

tttccccctt ctagcgagga gctgcaggcc aataaggcca ccctggtgtg cctgatcagc      480

gacttctacc ctggagcagt gaccgtggca tggaaggccg attcctctcc cgtgaaggcc      540

ggcgtggaga ccacaacccc ttccaagcag tctaacaata agtacgccgc cagctcctat      600

ctgagcctga cacctgagca gtggaagtcc cacaagagct attcctgcca ggtgacccac      660

gagggctcca ccgtggagaa gacagtggcc ccaaccgagt gttcttgata actcgag         717


<210>  29
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG9 IgG1

<400>  29

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Arg Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
            20                  25                  30          


Gly Ser Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Gln Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Phe Ile Lys Tyr Asp Gly Ser Glu Lys Tyr His Ala Asp 
65                  70                  75                  80  


Ser Val Trp Gly Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys Asp Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Phe Cys Val Arg Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn 
        115                 120                 125             


Tyr Tyr Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
    130                 135                 140                 


Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
145                 150                 155                 160 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
                165                 170                 175     


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
            180                 185                 190         


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
        195                 200                 205             


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
    210                 215                 220                 


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
225                 230                 235                 240 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys 
                245                 250                 255     


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            260                 265                 270         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        275                 280                 285             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    290                 295                 300                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
305                 310                 315                 320 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                325                 330                 335     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            340                 345                 350         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        355                 360                 365             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    370                 375                 380                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
385                 390                 395                 400 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                405                 410                 415     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            420                 425                 430         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        435                 440                 445             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    450                 455                 460                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
465                 470                 475                 480 


Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala 
                485                 490                 495     


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
            500                 505                 510         


Gly Pro Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys 
        515                 520                 525             


Pro Gly Gly Ser Asn Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val 
    530                 535                 540                 


Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Asn Gly Thr Ser 
545                 550                 555                 560 


Asn Asp Val Gly Gly Tyr Glu Ser Val Ser Trp Tyr Gln Gln His Pro 
                565                 570                 575     


Gly Lys Ala Pro Lys Val Val Ile Tyr Asp Val Ser Lys Arg Pro Ser 
            580                 585                 590         


Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
        595                 600                 605             


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys 
    610                 615                 620                 


Lys Ser Leu Thr Ser Thr Arg Arg Arg Val Phe Gly Thr Gly Thr Lys 
625                 630                 635                 640 


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
                645                 650                 655     


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
            660                 665                 670         


Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
        675                 680                 685             


Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys 
    690                 695                 700                 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
705                 710                 715                 720 


Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu 
                725                 730                 735     


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            740                 745                 750 


<210>  30
<211>  2274
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PG9 IgG1

<400>  30
ggatccgcca ccatggactg gacttggaga atcctgttcc tggtcgccgc cgctaccggg       60

actcacgctc agaggctggt ggagagtggg ggaggggtcg tgcagccagg cagctccctg      120

cgactgagtt gcgccgcttc agggttcgac ttttcccgac agggaatgca ctgggtcagg      180

caggcacctg gacagggact ggagtgggtg gcttttatca agtacgacgg aagtgaaaaa      240

tatcatgccg attcagtgtg ggggcggctg tcaattagcc gcgacaacag taaggatacc      300

ctgtacctgc agatgaatag cctgcgggtc gaggacacag ctacttattt ctgcgtgcgc      360

gaagcaggcg gaccagatta ccgaaacggg tataattact atgactttta cgatggctac      420

tataactacc actatatgga cgtgtggggc aagggaacca cagtcacagt gtctagtgca      480

tcaactaaag gacccagcgt gttccccctg gccccttcaa gcaagtccac ttctgggggc      540

accgcagccc tgggatgtct ggtgaaggat tacttccctg agccagtcac cgtgagttgg      600

aactcaggcg ccctgactag cggagtccat acctttcctg ctgtgctgca gtcctctggg      660

ctgtactccc tgagttcagt ggtcactgtg ccaagctcct ctctgggcac ccagacatat      720

atctgcaacg tgaatcacaa gcctagcaat accaaagtcg acaagaaagt ggaaccaaag      780

tcctgtgata aaactcatac ctgccctccc tgtccagcac ctgagctgct gggagggcct      840

tccgtgttcc tgtttccacc caagccaaaa gacacactga tgatttctag gacaccagaa      900

gtcacttgcg tggtcgtgga cgtgagccac gaggaccccg aagtcaagtt taactggtac      960

gtggatggcg tcgaggtgca taatgccaag accaaacccc gcgaggaaca gtacaactcc     1020

acatataggg tcgtgtctgt cctgactgtg ctgcaccagg actggctgaa cggcaaggag     1080

tataagtgca aagtgtccaa taaggcactg ccagccccca tcgagaaaac catttctaag     1140

gccaaaggac agccaagaga accccaggtg tacacactgc ctccatcccg ggacgagctg     1200

actaagaacc aggtctctct gacctgtctg gtgaaaggct tctatccctc tgatatcgct     1260

gtggagtggg aaagtaatgg acagcctgaa aacaattaca agactacccc tcccgtgctg     1320

gacagcgatg ggtccttctt tctgtatagc aagctgacag tggacaaatc cagatggcag     1380

cagggcaacg tctttagttg ctcagtgatg cacgaggccc tgcacaatca ttacacacag     1440

aaaagcctgt ccctgtctcc cggcaagagg ggaagaaaaa ggagaagtgg gtcaggcgca     1500

actaacttca gcctgctgaa gcaggccgga gatgtggagg aaaatcctgg gccaatggct     1560

tggacccctc tgttcctgtt cctgctgaca tgctgtcctg gcggaagcaa ctcccagtct     1620

gcactgaccc agccagcaag cgtgagcggg agcccaggcc agagcatcac catttcctgt     1680

aacggcacat ccaatgacgt gggcggctac gagtccgtgt cttggtatca gcagcatcct     1740

ggaaaggccc caaaagtcgt gatctacgat gtcagcaaaa gaccttctgg ggtgagtaac     1800

cggttcagtg gatcaaagag cgggaatacc gcttctctga caattagtgg cctgcaggca     1860

gaggacgaag gagattacta ttgcaagtca ctgacaagca ctcggcgccg agtcttcgga     1920

accgggacaa agctgactgt gctgggccag cccaaagctg caccttctgt gaccctgttt     1980

ccacccagtt cagaggaact gcaggctaac aaggccaccc tggtgtgcct gatcagcgac     2040

ttctaccctg gcgctgtcac tgtggcctgg aaggctgata gctccccagt caaagcagga     2100

gtggaaacaa ctaccccctc caagcagtct aacaacaagt acgccgcttc tagttatctg     2160

tcactgaccc cagagcagtg gaagtctcac aaatcctatt cttgtcaggt cacccatgaa     2220

gggagcactg tggagaaaac cgtcgcacca accgaatgtt cctgataact cgag           2274


<210>  31
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG9 human IgG4

<400>  31

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Arg Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
            20                  25                  30          


Gly Ser Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Gln Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Phe Ile Lys Tyr Asp Gly Ser Glu Lys Tyr His Ala Asp 
65                  70                  75                  80  


Ser Val Trp Gly Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys Asp Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Phe Cys Val Arg Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn 
        115                 120                 125             


Tyr Tyr Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
    130                 135                 140                 


Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
145                 150                 155                 160 


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
                165                 170                 175     


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
            180                 185                 190         


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
        195                 200                 205             


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
    210                 215                 220                 


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
225                 230                 235                 240 


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
                245                 250                 255     


Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
    290                 295                 300                 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
465                 470                 475                 480 


Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe 
                485                 490                 495     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly Gly 
        515                 520                 525             


Ser Asn Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser 
    530                 535                 540                 


Pro Gly Gln Ser Ile Thr Ile Ser Cys Asn Gly Thr Ser Asn Asp Val 
545                 550                 555                 560 


Gly Gly Tyr Glu Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala 
                565                 570                 575     


Pro Lys Val Val Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser 
            580                 585                 590         


Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile 
        595                 600                 605             


Ser Gly Leu Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Lys Ser Leu 
    610                 615                 620                 


Thr Ser Thr Arg Arg Arg Val Phe Gly Thr Gly Thr Lys Leu Thr Val 
625                 630                 635                 640 


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
                645                 650                 655     


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
            660                 665                 670         


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
        675                 680                 685             


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
    690                 695                 700                 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
705                 710                 715                 720 


Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
                725                 730                 735     


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            740                 745         


<210>  32
<211>  2265
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PG9 human IgG4

<400>  32
ggatccgcca ccatggactg gacctggcgc atcctgtttc tggtggcagc agcaacagga       60

acccacgcac agaggctggt ggagagcggc ggcggcgtgg tgcagcctgg cagctccctg      120

agactgtcct gcgcagcatc tggcttcgac ttcagcaggc agggcatgca ctgggtgcgg      180

caggcaccag gacagggact ggagtgggtg gccttcatca agtacgacgg ctctgagaag      240

tatcacgcag atagcgtgtg gggccgcctg tccatctcta gggacaacag caaggatacc      300

ctgtacctgc agatgaattc cctgcgcgtg gaggacacag ccacctattt ctgcgtgagg      360

gaggccggcg gaccagatta caggaacggc tataattact atgactttta cgatggctac      420

tataactacc actatatgga cgtgtggggc aagggcacca cagtgacagt gtctagcgcc      480

tccaccaagg gaccaagcgt gttccctctg gcaccatgca gcaggtccac ctctgagagc      540

acagccgccc tgggctgtct ggtgaaggat tatttccctg agccagtgac cgtgagctgg      600

aattccggcg ccctgacatc cggagtgcac acctttcctg ccgtgctgca gtcctctggc      660

ctgtacagcc tgagctccgt ggtgacagtg ccctctagct ccctgggcac aaagacctat      720

acatgcaacg tggaccacaa gccttccaat accaaggtgg ataagagagt ggagagcaag      780

tacggccctc cctgcccatc ctgtccagca cctgagttcc tgggcggccc aagcgtgttc      840

ctgtttccac ccaagcccaa ggacacactg atgatcagcc ggacccctga ggtgacatgc      900

gtggtggtgg acgtgtccca ggaggacccc gaggtgcagt tcaactggta cgtggatggc      960

gtggaggtgc acaatgccaa gaccaagccc agagaggagc agtttaacag cacataccgg     1020

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaagga gtataagtgc     1080

aaggtgtcta ataagggcct gccttctagc atcgagaaga caatcagcaa ggcaaaggga     1140

cagccccggg agcctcaggt gtacaccctg cctccatctc aggaggagat gacaaagaac     1200

caggtgagcc tgacctgtct ggtgaagggc ttttatccat ctgacatcgc cgtggagtgg     1260

gagagcaatg gccagcccga gaacaattac aagaccacac cccctgtgct ggactctgat     1320

ggcagcttct ttctgtattc ccgcctgact gtggataagt ctaggtggca ggagggcaac     1380

gtgttttcct gctctgtgat gcacgaggcc ctgcacaatc actacacaca gaagagcctg     1440

tccctgtctc tgggcaagag aggaaggaag aggagaagcg gctccggagc aaccaacttc     1500

agcctgctga agcaggcagg cgacgtggag gagaatccag gacccatggc ctggacacct     1560

ctgttcctgt ttctgctgac ctgctgtcca ggcggctcta acagccagtc cgccctgacc     1620

cagccagcat ctgtgagcgg ctcccctggc cagagcatca caatctcctg taacggcacc     1680

tccaatgacg tgggcggcta cgagtctgtg agctggtatc agcagcaccc aggcaaggcc     1740

cccaaggtgg tcatctacga tgtgagcaag agaccctccg gcgtgtctaa ccggttctcc     1800

ggctctaaga gcggcaatac cgcctctctg acaatcagcg gactgcaggc agaggacgag     1860

ggcgattact attgcaagag cctgacctcc acacggcgca gggtgttcgg aaccggcaca     1920

aagctgacag tgctgggaca gcctaaggca gcaccatccg tgaccctgtt tccaccctcc     1980

tctgaggagc tgcaggccaa caaggccacc ctggtgtgcc tgatcagcga cttctaccct     2040

ggagcagtga ccgtggcatg gaaggcagat agctccccag tgaaggcagg agtggagacc     2100

acaacccctt ctaagcagag caacaataag tacgccgcct ctagctatct gtccctgaca     2160

ccagagcagt ggaagtctca caagtcctat tcttgccagg tgacccacga gggctccacc     2220

gtggagaaga cagtggcccc caccgagtgt tcttgataac tcgag                     2265


<210>  33
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NIH45-46human IgG1 antibody

<400>  33

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Leu Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Leu Asn Cys Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Arg Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn 
        115                 120                 125             


Trp Asp Phe Glu His Trp Gly Arg Gly Ala Pro Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg 
465                 470                 475                 480 


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
                485                 490                 495     


Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile 
            500                 505                 510         


Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Glu Ile Val Leu Thr 
        515                 520                 525             


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Ile Ile 
    530                 535                 540                 


Ser Cys Arg Thr Ser Gln Ser Gly Ser Leu Ala Trp Tyr Gln Gln Arg 
545                 550                 555                 560 


Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr Arg Ala 
                565                 570                 575     


Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly Ala Asp Tyr 
            580                 585                 590         


Asn Leu Ser Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly Val Tyr Tyr 
        595                 600                 605             


Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val Gln Val Asp 
    610                 615                 620                 


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
625                 630                 635                 640 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
                645                 650                 655     


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
            660                 665                 670         


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
        675                 680                 685             


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
    690                 695                 700                 


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
705                 710                 715                 720 


Arg Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730             


<210>  34
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NIH45-46human IgG1 antibody

<400>  34
ggatccgcca ccatggactg gacctggcgc atcctgttcc tggtggcagc agcaaccgga       60

acacacgcac aggtgaggct gtcccagtct ggcggccaga tgaagaagcc tggagagtct      120

atgaggctga gctgcagggc atccggatac gagttcctga actgtccaat caattggatc      180

agactggccc ctggcaggag accagagtgg atgggatggc tgaagcctcg gggcggcgcc      240

gtgaactacg caaggaagtt tcagggcaga gtgaccatga cacgggacgt gtatagcgat      300

accgccttcc tggagctgag atctctgacc agcgacgata cagccgtgta cttttgcacc      360

cgcggcaagt attgtacagc cagggactac tataattggg atttcgagca ctggggaagg      420

ggcgccccag tgaccgtgag ctccgcctcc acaaagggac ctagcgtgtt cccactggca      480

ccttctagca agagcacctc cggcggcaca gccgccctgg gatgcctggt gaaggactac      540

ttccctgagc cagtgaccgt gtcctggaac tctggcgccc tgaccagcgg agtgcacaca      600

tttccagccg tgctgcagtc ctctggcctg tactccctga gctccgtggt gaccgtgccc      660

tctagctccc tgggcaccca gacatatatc tgcaacgtga atcacaagcc atctaataca      720

aaggtggaca agaaggtgga gcccaagagc tgtgataaga cccacacatg ccctccctgt      780

ccagcacctg agctgctggg cggcccttcc gtgttcctgt ttccacccaa gccaaaggac      840

acactgatga tctccagaac ccccgaggtg acatgcgtgg tggtggacgt gtctcacgag      900

gaccccgagg tgaagttcaa ctggtacgtg gatggcgtgg aggtgcacaa tgccaagacc      960

aagccaagag aggagcagta caactctacc tatcgggtgg tgagcgtgct gacagtgctg     1020

caccaggatt ggctgaacgg caaggagtat aagtgcaagg tgagcaataa ggccctgcca     1080

gcccccatcg agaagaccat ctccaaggcc aagggccagc caagagagcc ccaggtgtac     1140

acactgcctc caagccggga cgagctgacc aagaaccagg tgtccctgac atgtctggtg     1200

aagggcttct atccttccga tatcgccgtg gagtgggagt ctaatggcca gccagagaac     1260

aattacaaga ccacaccccc tgtgctggac agcgatggct ccttctttct gtatagcaag     1320

ctgaccgtgg acaagtcccg gtggcagcag ggcaacgtgt tttcttgcag cgtgatgcac     1380

gaggccctgc acaatcacta cacccagaag tccctgtctc tgagcccagg caagagggga     1440

agaaagcggc gctccggctc tggagccaca aacttcagcc tgctgaagca ggccggcgat     1500

gtggaggaga atcctggccc aatggtgctg cagacccagg tgtttatctc cctgctgctg     1560

tggatctctg gcgcctacgg cgagatcgtg ctgacccagt ctccagccac actgagcctg     1620

tccccaggag agaccgcaat catctcctgt cgcacatctc agagcggctc cctggcatgg     1680

taccagcaga gaccaggaca ggcccctcgg ctggtcatct actctggcag cacaagggcc     1740

gcaggcatcc ccgaccgctt ctccggctct aggtggggcg ccgattacaa cctgagcatc     1800

tccaatctgg agagcggcga ctttggcgtg tactattgcc agcagtatga gttctttggc     1860

cagggcacca aggtgcaggt ggacatcaag cgcacagtgg ccgcccccag cgtgttcatc     1920

tttccaccca gcgatgagca gctgaagtct ggcaccgcca gcgtggtgtg cctgctgaac     1980

aatttctacc ctagggaggc caaggtgcag tggaaggtgg acaacgccct gcagtctggc     2040

aatagccagg agtccgtgac cgagcaggac tctaaggata gcacatattc cctgtctagc     2100

accctgacac tgtccaaggc cgattacgag aagcacaagg tgtatgcatg cgaggtgacc     2160

caccagggac tgcgcagccc cgtgacaaag tcctttaaca ggggcgagtg ttgataactc     2220

gag                                                                   2223


<210>  35
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NIH45-46human IgG4 antibody

<400>  35

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Leu Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Leu Asn Cys Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Arg Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn 
        115                 120                 125             


Trp Asp Phe Glu His Trp Gly Arg Gly Ala Pro Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
                245                 250                 255     


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser 
465                 470                 475                 480 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                485                 490                 495     


Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu 
            500                 505                 510         


Leu Trp Ile Ser Gly Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro 
        515                 520                 525             


Ala Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Ile Ile Ser Cys Arg 
    530                 535                 540                 


Thr Ser Gln Ser Gly Ser Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
545                 550                 555                 560 


Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr Arg Ala Ala Gly Ile 
                565                 570                 575     


Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly Ala Asp Tyr Asn Leu Ser 
            580                 585                 590         


Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly Val Tyr Tyr Cys Gln Gln 
        595                 600                 605             


Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val Gln Val Asp Ile Lys Arg 
    610                 615                 620                 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
625                 630                 635                 640 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
                645                 650                 655     


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
            660                 665                 670         


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
        675                 680                 685             


Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
    690                 695                 700                 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
705                 710                 715                 720 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730 


<210>  36
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NIH45-46human IgG4 antibody

<400>  36
ggatccgcca ccatggactg gacctggaga atcctgttcc tggtggcagc agcaaccgga       60

acacacgcac aggtgcggct gtcccagtct ggcggccaga tgaagaagcc aggagagtct      120

atgaggctga gctgcagggc atccggatac gagttcctga actgtcctat caattggatc      180

aggctggcac caggcaggag acccgagtgg atgggatggc tgaagcccag gggcggcgcc      240

gtgaactacg caaggaagtt tcagggcaga gtgaccatga cacgggacgt gtattccgat      300

accgccttcc tggagctgag aagcctgaca tccgacgata ccgccgtgta cttttgcaca      360

cgcggcaagt attgtaccgc cagggactac tataattggg atttcgagca ctggggaaga      420

ggcgcccctg tgacagtgag ctccgcctcc accaagggcc caagcgtgtt ccctctggcc      480

ccatgcagcc ggtccacatc tgagagcacc gccgccctgg gatgtctggt gaaggactac      540

ttccctgagc cagtgaccgt gtcttggaac agcggcgccc tgacatctgg cgtgcacacc      600

tttcccgccg tgctgcagtc tagcggcctg tacagcctgt cctctgtggt gacagtgcct      660

agctcctctc tgggcaccaa gacatatacc tgcaacgtgg accacaagcc atccaatacc      720

aaggtggata agcgcgtgga gtctaagtac ggccctccct gccctagctg tccagcacct      780

gagttcctgg gcggcccaag cgtgttcctg tttccaccca agcccaagga caccctgatg      840

atctctagga caccagaggt gacctgcgtg gtggtggacg tgagccagga ggaccccgag      900

gtgcagttca actggtacgt ggatggcgtg gaggtgcaca atgccaagac aaagcctcgc      960

gaggagcagt ttaacagcac atacagggtg gtgtccgtgc tgaccgtgct gcaccaggat     1020

tggctgaacg gcaaggagta taagtgcaag gtgtccaata agggcctgcc aagctccatc     1080

gagaagacaa tctctaaggc aaagggacag ccccgggagc ctcaggtgta caccctgcct     1140

ccaagccagg aggagatgac aaagaaccag gtgtccctga cctgtctggt gaagggcttc     1200

tatccctccg acatcgccgt ggagtgggag tctaatggcc agcctgagaa caattacaag     1260

accacacccc ctgtgctgga ctccgatggc tctttctttc tgtattccag actgaccgtg     1320

gataagtctc ggtggcagga gggcaacgtg ttttcctgct ctgtgatgca cgaggccctg     1380

cacaatcact acacacagaa gagcctgtcc ctgtctctgg gcaagagggg aagaaagcgg     1440

cgcagcggct ccggagcaac caacttctcc ctgctgaagc aggcaggcga cgtggaggag     1500

aatccaggac ccatggtgct gcagacacag gtgtttatct ctctgctgct gtggatcagc     1560

ggcgcctacg gcgagatcgt gctgacacag agcccagcca ccctgtctct gagccctgga     1620

gagacagcca tcatctcctg tcgcacctcc cagtctggca gcctggcatg gtaccagcag     1680

agacctggac aggccccacg gctggtcatc tactccggct ctaccagggc cgcaggcatc     1740

ccagaccgct tcagcggctc caggtggggc gccgattaca acctgtctat cagcaatctg     1800

gagagcggcg attttggcgt gtactattgc cagcagtatg agttctttgg ccagggcaca     1860

aaggtgcagg tggacatcaa gagaaccgtg gccgccccaa gcgtgttcat ctttccaccc     1920

tccgatgagc agctgaagtc tggcacagcc agcgtggtgt gcctgctgaa caatttctac     1980

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caattcccag     2040

gagtctgtga cagagcagga cagcaaggat tccacctatt ccctgtctaa cacactgacc     2100

ctgtccaagg ccgattacga gaagcacaag gtgtatgcct gcgaggtgac acaccagggc     2160

ctgtctagcc ctgtgaccaa gagctttaat cgcggcgagt gttgataact cgag           2214


<210>  37
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG1

<400>  37

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly 
465                 470                 475                 480 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
                485                 490                 495     


Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu 
            500                 505                 510         


Trp Ile Ser Gly Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
        515                 520                 525             


Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Ile Ile Ser Cys Arg Thr 
    530                 535                 540                 


Ser Gln Tyr Gly Ser Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala 
545                 550                 555                 560 


Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr Arg Ala Ala Gly Ile Pro 
                565                 570                 575     


Asp Arg Phe Ser Gly Ser Arg Trp Gly Pro Asp Tyr Asn Leu Thr Ile 
            580                 585                 590         


Ser Asn Leu Glu Ser Gly Asp Phe Gly Val Tyr Tyr Cys Gln Gln Tyr 
        595                 600                 605             


Glu Phe Phe Gly Gln Gly Thr Lys Val Gln Val Asp Ile Lys Arg Thr 
    610                 615                 620                 


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
625                 630                 635                 640 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
                645                 650                 655     


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
            660                 665                 670         


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
        675                 680                 685             


Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
    690                 695                 700                 


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
705                 710                 715                 720 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 


<210>  38
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG1

<400>  38
ggatccgcca ccatggattg gacatggagg attctgtttc tggtcgccgc cgccacagga       60

actcatgctc aggtgcagct ggtgcagtca ggagggcaga tgaagaaacc tggcgagagt      120

atgcgaatct catgcagggc tagcggatac gaattcatcg actgtaccct gaactggatt      180

agactggcac ctggaaagcg gccagagtgg atggggtggc tgaaaccaag aggcggagca      240

gtgaattacg ccagaccact gcagggacga gtcactatga cccgcgacgt gtatagcgat      300

accgcattcc tggaactgcg atccctgaca gtcgacgata ctgccgtgta cttctgcaca      360

aggggcaaga actgtgacta taattgggat tttgagcact ggggccgggg aacaccagtc      420

attgtgagct ccgcaagtac taaggggccc tcagtgtttc ccctggctcc ttctagtaaa      480

agtacctcag ggggcacagc cgctctggga tgcctggtga aggattactt ccctgagcca      540

gtcacagtga gttggaactc aggcgccctg acatctggag tccatacttt tcccgctgtg      600

ctgcagtcaa gcggactgta cagcctgtcc tctgtggtca cagtgcctag ttcaagcctg      660

gggacacaga cttatatctg caacgtcaat cacaagccca gcaatactaa agtggacaag      720

aaagtggaac ctaagtcctg tgataaaacc catacatgcc ctccctgtcc agctcctgag      780

ctgctgggag ggccaagcgt gttcctgttt ccacccaagc ctaaagacac cctgatgatt      840

tctcggactc ctgaagtcac ctgcgtggtc gtggacgtga gccacgagga ccccgaagtc      900

aagtttaact ggtacgtgga tggcgtcgag gtgcataatg ccaagacaaa acccagggag      960

gaacagtaca acagcaccta tagagtcgtg tccgtcctga cagtgctgca ccaggactgg     1020

ctgaacggaa aggagtataa gtgcaaagtg agcaataagg ccctgccagc tcccatcgag     1080

aaaacaattt ccaaggcaaa agggcagcca cgggaacccc aggtgtacac tctgcctcca     1140

tctcgcgacg agctgactaa gaaccaggtc agcctgacct gtctggtgaa agggttctat     1200

ccaagtgata tcgccgtgga gtgggaaagc aatggccagc ccgaaaacaa ttacaagacc     1260

acaccccctg tgctggacag cgatggctcc ttctttctgt attctaagct gaccgtggat     1320

aaaagtcgct ggcagcaggg aaacgtcttt agctgctccg tgatgcacga ggctctgcac     1380

aatcattaca cccagaagtc tctgagtctg tcacctggca agcggggacg caaaaggaga     1440

agcgggtccg gcgctacaaa cttcagcctg ctgaagcagg caggcgacgt ggaggaaaat     1500

cctggaccaa tggtcctgca gacccaggtg ttcatctccc tgctgctgtg gatttctggg     1560

gcatacggcg aaattgtgct gacccagagc cctgggacac tgtctctgag tccaggcgag     1620

acagccatca tttcctgtcg gacttctcag tacggaagtc tggcatggta tcagcagcga     1680

ccaggacagg ctcctcgact ggtcatctac tcagggagca ctagggcagc cggcattcct     1740

gaccgattct ccggatctag gtgggggcct gattacaacc tgaccatctc aaatctggaa     1800

agcggggact ttggcgtgta ctattgccag cagtatgagt tctttggaca ggggaccaag     1860

gtccaggtgg acatcaaacg cacagtcgct gcaccatccg tgttcatttt tccaccctct     1920

gatgaacagc tgaagtccgg caccgcctct gtggtgtgcc tgctgaacaa tttctacccc     1980

agggaggcaa aggtccagtg gaaagtggac aacgccctgc agtctggaaa tagtcaggag     2040

tcagtgactg aacaggacag caaggattcc acctattctc tgtccaacac tctgaccctg     2100

tccaaagctg attacgagaa gcacaaagtg tatgcatgcg aggtcactca ccaggggctg     2160

tcatcaccag tcacaaaatc cttcaacaga ggggaatgct gataactcga g              2211


<210>  39
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG1(heavy chain) (mod1)

<400>  39

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  40
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG1(heavy chain) (mod1)

<400>  40
ggatccgcca ccatggattg gacatggagg attctgtttc tggtcgccgc cgccacagga       60

actcatgctc aggtgcagct ggtgcagtca ggagggcaga tgaagaaacc tggcgagagt      120

atgcgaatct catgcagggc tagcggatac gaattcatcg actgtaccct gaactggatt      180

agactggcac ctggaaagcg gccagagtgg atggggtggc tgaaaccaag aggcggagca      240

gtgaattacg ccagaccact gcagggacga gtcactatga cccgcgacgt gtatagcgat      300

accgcattcc tggaactgcg atccctgaca gtcgacgata ctgccgtgta cttctgcaca      360

aggggcaaga actgtgacta taattgggat tttgagcact ggggccgggg aacaccagtc      420

attgtgagct ccgcaagtac taaggggccc tcagtgtttc ccctggctcc ttctagtaaa      480

agtacctcag ggggcacagc cgctctggga tgcctggtga aggattactt ccctgagcca      540

gtcacagtga gttggaactc aggcgccctg acatctggag tccatacttt tcccgctgtg      600

ctgcagtcaa gcggactgta cagcctgtcc tctgtggtca cagtgcctag ttcaagcctg      660

gggacacaga cttatatctg caacgtcaat cacaagccca gcaatactaa agtggacaag      720

aaagtggaac ctaagtcctg tgataaaacc catacatgcc ctccctgtcc agctcctgag      780

ctgctgggag ggccaagcgt gttcctgttt ccacccaagc ctaaagacac cctgatgatt      840

tctcggactc ctgaagtcac ctgcgtggtc gtggacgtga gccacgagga ccccgaagtc      900

aagtttaact ggtacgtgga tggcgtcgag gtgcataatg ccaagacaaa acccagggag      960

gaacagtaca acagcaccta tagagtcgtg tccgtcctga cagtgctgca ccaggactgg     1020

ctgaacggaa aggagtataa gtgcaaagtg agcaataagg ccctgccagc tcccatcgag     1080

aaaacaattt ccaaggcaaa agggcagcca cgggaacccc aggtgtacac tctgcctcca     1140

tctcgcgacg agctgactaa gaaccaggtc agcctgacct gtctggtgaa agggttctat     1200

ccaagtgata tcgccgtgga gtgggaaagc aatggccagc ccgaaaacaa ttacaagacc     1260

acaccccctg tgctggacag cgatggctcc ttctttctgt attctaagct gaccgtggat     1320

aaaagtcgct ggcagcaggg aaacgtcttt agctgctccg tgatgcacga ggctctgcac     1380

aatcattaca cccagaagtc tctgagtctg tcacctggca agtgataact cgag           1434


<210>  41
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG1(light chain)(mod1)

<400>  41

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr 
        35                  40                  45              


Gly Ser Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu 
    50                  55                  60                  


Val Ile Tyr Ser Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Arg Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu 
                85                  90                  95      


Glu Ser Gly Asp Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe 
            100                 105                 110         


Gly Gln Gly Thr Lys Val Gln Val Asp Ile Lys Arg Thr Val Ala Ala 
        115                 120                 125             


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
    130                 135                 140                 


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
145                 150                 155                 160 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
                165                 170                 175     


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
            180                 185                 190         


Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
        195                 200                 205             


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
    210                 215                 220                 


Phe Asn Arg Gly Glu Cys 
225                 230 


<210>  42
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG1(light chain)(mod1)

<400>  42
ggatccgcca ccatggtcct gcagacccag gtgttcatct ccctgctgct gtggatttct       60

ggggcatacg gcgaaattgt gctgacccag agccctggga cactgtctct gagtccaggc      120

gagacagcca tcatttcctg tcggacttct cagtacggaa gtctggcatg gtatcagcag      180

cgaccaggac aggctcctcg actggtcatc tactcaggga gcactagggc agccggcatt      240

cctgaccgat tctccggatc taggtggggg cctgattaca acctgaccat ctcaaatctg      300

gaaagcgggg actttggcgt gtactattgc cagcagtatg agttctttgg acaggggacc      360

aaggtccagg tggacatcaa acgcacagtc gctgcaccat ccgtgttcat ttttccaccc      420

tctgatgaac agctgaagtc cggcaccgcc tctgtggtgt gcctgctgaa caatttctac      480

cccagggagg caaaggtcca gtggaaagtg gacaacgccc tgcagtctgg aaatagtcag      540

gagtcagtga ctgaacagga cagcaaggat tccacctatt ctctgtccaa cactctgacc      600

ctgtccaaag ctgattacga gaagcacaaa gtgtatgcat gcgaggtcac tcaccagggg      660

ctgtcatcac cagtcacaaa atccttcaac agaggggaat gctgataact cgag            714


<210>  43
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG4 (mod 2)

<400>  43

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Leu Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn 
465                 470                 475                 480 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                485                 490                 495     


Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
            500                 505                 510         


Gly Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
        515                 520                 525             


Leu Ser Pro Gly Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr 
    530                 535                 540                 


Gly Ser Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu 
545                 550                 555                 560 


Val Ile Tyr Ser Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe 
                565                 570                 575     


Ser Gly Ser Arg Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu 
            580                 585                 590         


Glu Ser Gly Asp Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe 
        595                 600                 605             


Gly Gln Gly Thr Lys Val Gln Val Asp Ile Lys Arg Thr Val Ala Ala 
    610                 615                 620                 


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
625                 630                 635                 640 


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
                645                 650                 655     


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
            660                 665                 670         


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
        675                 680                 685             


Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
    690                 695                 700                 


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
705                 710                 715                 720 


Phe Asn Arg Gly Glu Cys 
                725     


<210>  44
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG4 (mod 2)

<400>  44
ggatccgcca ccatggattg gacttggagg attctgtttc tggtcgccgc cgctactgga       60

acccatgctc aggtgcagct ggtgcagtca ggagggcaga tgaagaaacc tggagagagc      120

atgcgaatct cctgcagggc ctctgggtac gaattcatcg actgtacact gaactggatt      180

agactggctc ctgggaagcg gccagagtgg atgggctggc tgaaaccaag aggcggagca      240

gtgaattacg ccagaccact gcagggacga gtcactatga cccgcgacgt gtattctgat      300

actgcttttc tggaactgcg aagtctgacc gtcgacgata cagcagtgta cttctgcacc      360

aggggcaaga actgtgacta taattgggat tttgagcact ggggaagagg gactcctgtc      420

attgtgagct ccgcaagcac caagggacca tccgtgttcc cactggcacc ttgcagtcgg      480

tcaactagcg agtccaccgc cgctctggga tgtctggtga aggattactt cccagaaccc      540

gtcaccgtga gctggaactc cggagccctg accagcggag tccatacatt tcctgctgtg      600

ctgcagtcta gtggactgta ctccctgtca agcgtggtca ccgtcccttc ctctagtctg      660

gggacaaaga cttatacctg caacgtggac cacaaaccat ccaatacaaa ggtcgataaa      720

cgcgtggagt caaagtacgg ccctccctgc cctagctgtc cagctcctga gttcctgggc      780

ggcccaagcg tgttcctgtt tccccctaag cctaaagaca cactgatgat ctctaggaca      840

ccagaagtca cttgcgtggt cgtggacgtg agccaggagg accccgaagt ccagttcaac      900

tggtacgtgg atggcgtcga ggtgcacaat gccaagacca aacctcggga ggaacagttt      960

aactctactt accgcgtcgt gagtgtcctg accgtgctgc atcaggactg gctgaacggc     1020

aaggagtata agtgcaaagt gtccaataag ggactgccat caagcatcga gaaaaccatt     1080

tctaaggcaa aaggccagcc aagagaaccc caggtgtaca cactgccacc cagccaggag     1140

gaaatgacaa agaaccaggt ctccctgact tgtctggtga aagggtttta tccaagcgac     1200

attgccgtgg agtgggaatc caatggccag cccgagaaca attacaagac cacacctcca     1260

gtgctggact ctgatggcag tttctttctg tattcaaggc tgaccgtgga taaaagcaga     1320

tggcaggagg gaaacgtctt ctcttgcagt gtgatgcacg aagctctgca caatcattac     1380

actcagaagt cactgagcct gtccctggga aagcgaggac gaaaaaggag atctggcagt     1440

ggagctacca acttcagcct gctgaagcag gcaggagacg tggaggaaaa tcctgggcca     1500

atggtcctgc agactcaggt gttcatcagt ctgctgctgt ggatttcagg cgcctacgga     1560

gagattgtgc tgactcagtc tcccggcacc ctgtcactga gccctggaga aaccgccatc     1620

attagttgtc gaacatcaca gtacgggagc ctggcatggt atcagcagcg accaggacag     1680

gctccccgac tggtcatcta ctccggctct acacgggcag ccggaattcc cgaccgattc     1740

agtgggtcaa ggtggggccc tgattacaac ctgactatct ccaatctgga gtctggcgac     1800

tttggagtgt actattgcca gcagtatgaa ttctttgggc agggcaccaa ggtccaggtg     1860

gacatcaaaa gaacagtcgc tgcaccaagc gtgttcatct ttcccccttc agatgagcag     1920

ctgaagagtg gaaccgcctc agtggtgtgc ctgctgaaca atttctaccc ccgggaagca     1980

aaggtccagt ggaaagtgga caacgccctg cagtcaggca atagccagga gtccgtgaca     2040

gaacaggact ctaaggatag tacttattca ctgtccaaca cactgactct gtccaaagct     2100

gattacgaga agcacaaagt gtatgcatgc gaggtcaccc accaggggct gtcatcaccc     2160

gtcaccaagt ctttcaatag gggcgaatgt tgataactcg ag                        2202


<210>  45
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG4 mut (S228P) (mod 3)

<400>  45

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Leu Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn 
465                 470                 475                 480 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                485                 490                 495     


Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
            500                 505                 510         


Gly Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
        515                 520                 525             


Leu Ser Pro Gly Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr 
    530                 535                 540                 


Gly Ser Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu 
545                 550                 555                 560 


Val Ile Tyr Ser Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe 
                565                 570                 575     


Ser Gly Ser Arg Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu 
            580                 585                 590         


Glu Ser Gly Asp Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe 
        595                 600                 605             


Gly Gln Gly Thr Lys Val Gln Val Asp Ile Lys Arg Thr Val Ala Ala 
    610                 615                 620                 


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
625                 630                 635                 640 


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
                645                 650                 655     


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
            660                 665                 670         


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
        675                 680                 685             


Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
    690                 695                 700                 


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
705                 710                 715                 720 


Phe Asn Arg Gly Glu Cys 
                725     


<210>  46
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG4 mut (S228P) (mod 3)

<400>  46
ggatccgcca ccatggattg gacttggagg attctgtttc tggtcgccgc cgctactgga       60

acccatgctc aggtgcagct ggtgcagtca ggagggcaga tgaagaaacc tggagagagc      120

atgcgaatct cctgcagggc ctctgggtac gaattcatcg actgtacact gaactggatt      180

agactggctc ctgggaagcg gccagagtgg atgggctggc tgaaaccaag aggcggagca      240

gtgaattacg ccagaccact gcagggacga gtcactatga cccgcgacgt gtattctgat      300

actgcttttc tggaactgcg aagtctgacc gtcgacgata cagcagtgta cttctgcacc      360

aggggcaaga actgtgacta taattgggat tttgagcact ggggaagagg gactcctgtc      420

attgtgagct ccgcaagcac caagggacca tccgtgttcc cactggcacc ttgcagtcgg      480

tcaactagcg agtccaccgc cgctctggga tgtctggtga aggattactt cccagaaccc      540

gtcaccgtga gctggaactc cggagccctg accagcggag tccatacatt tcctgctgtg      600

ctgcagtcta gtggactgta ctccctgtca agcgtggtca ccgtcccttc ctctagtctg      660

gggacaaaga cttatacctg caacgtggac cacaaaccat ccaatacaaa ggtcgataaa      720

cgcgtggagt caaagtacgg ccctccctgc cctccctgtc cagctcctga gttcctgggc      780

ggcccaagcg tgttcctgtt tccccctaag cctaaagaca cactgatgat ctctaggaca      840

ccagaagtca cttgcgtggt cgtggacgtg agccaggagg accccgaagt ccagttcaac      900

tggtacgtgg atggcgtcga ggtgcacaat gccaagacca aacctcggga ggaacagttt      960

aactctactt accgcgtcgt gagtgtcctg accgtgctgc atcaggactg gctgaacggc     1020

aaggagtata agtgcaaagt gtccaataag ggactgccat caagcatcga gaaaaccatt     1080

tctaaggcaa aaggccagcc aagagaaccc caggtgtaca cactgccacc cagccaggag     1140

gaaatgacaa agaaccaggt ctccctgact tgtctggtga aagggtttta tccaagcgac     1200

attgccgtgg agtgggaatc caatggccag cccgagaaca attacaagac cacacctcca     1260

gtgctggact ctgatggcag tttctttctg tattcaaggc tgaccgtgga taaaagcaga     1320

tggcaggagg gaaacgtctt ctcttgcagt gtgatgcacg aagctctgca caatcattac     1380

actcagaagt cactgagcct gtccctggga aagcgaggac gaaaaaggag atctggcagt     1440

ggagctacca acttcagcct gctgaagcag gcaggagacg tggaggaaaa tcctgggcca     1500

atggtcctgc agactcaggt gttcatcagt ctgctgctgt ggatttcagg cgcctacgga     1560

gagattgtgc tgactcagtc tcccggcacc ctgtcactga gccctggaga aaccgccatc     1620

attagttgtc gaacatcaca gtacgggagc ctggcatggt atcagcagcg accaggacag     1680

gctccccgac tggtcatcta ctccggctct acacgggcag ccggaattcc cgaccgattc     1740

agtgggtcaa ggtggggccc tgattacaac ctgactatct ccaatctgga gtctggcgac     1800

tttggagtgt actattgcca gcagtatgaa ttctttgggc agggcaccaa ggtccaggtg     1860

gacatcaaaa gaacagtcgc tgcaccaagc gtgttcatct ttcccccttc agatgagcag     1920

ctgaagagtg gaaccgcctc agtggtgtgc ctgctgaaca atttctaccc ccgggaagca     1980

aaggtccagt ggaaagtgga caacgccctg cagtcaggca atagccagga gtccgtgaca     2040

gaacaggact ctaaggatag tacttattca ctgtccaaca cactgactct gtccaaagct     2100

gattacgaga agcacaaagt gtatgcatgc gaggtcaccc accaggggct gtcatcaccc     2160

gtcaccaagt ctttcaatag gggcgaatgt tgataactcg ag                        2202


<210>  47
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG4 (heavy chain) (mod4)

<400>  47

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Leu Gly Lys 
465         


<210>  48
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG4 (heavy chain) (mod4)

<400>  48
ggatccgcca ccatggattg gacttggagg attctgtttc tggtcgccgc cgctactgga       60

acccatgctc aggtgcagct ggtgcagtca ggagggcaga tgaagaaacc tggagagagc      120

atgcgaatct cctgcagggc ctctgggtac gaattcatcg actgtacact gaactggatt      180

agactggctc ctgggaagcg gccagagtgg atgggctggc tgaaaccaag aggcggagca      240

gtgaattacg ccagaccact gcagggacga gtcactatga cccgcgacgt gtattctgat      300

actgcttttc tggaactgcg aagtctgacc gtcgacgata cagcagtgta cttctgcacc      360

aggggcaaga actgtgacta taattgggat tttgagcact ggggaagagg gactcctgtc      420

attgtgagct ccgcaagcac caagggacca tccgtgttcc cactggcacc ttgcagtcgg      480

tcaactagcg agtccaccgc cgctctggga tgtctggtga aggattactt cccagaaccc      540

gtcaccgtga gctggaactc cggagccctg accagcggag tccatacatt tcctgctgtg      600

ctgcagtcta gtggactgta ctccctgtca agcgtggtca ccgtcccttc ctctagtctg      660

gggacaaaga cttatacctg caacgtggac cacaaaccat ccaatacaaa ggtcgataaa      720

cgcgtggagt caaagtacgg ccctccctgc cctccctgtc cagctcctga gttcctgggc      780

ggcccaagcg tgttcctgtt tccccctaag cctaaagaca cactgatgat ctctaggaca      840

ccagaagtca cttgcgtggt cgtggacgtg agccaggagg accccgaagt ccagttcaac      900

tggtacgtgg atggcgtcga ggtgcacaat gccaagacca aacctcggga ggaacagttt      960

aactctactt accgcgtcgt gagtgtcctg accgtgctgc atcaggactg gctgaacggc     1020

aaggagtata agtgcaaagt gtccaataag ggactgccat caagcatcga gaaaaccatt     1080

tctaaggcaa aaggccagcc aagagaaccc caggtgtaca cactgccacc cagccaggag     1140

gaaatgacaa agaaccaggt ctccctgact tgtctggtga aagggtttta tccaagcgac     1200

attgccgtgg agtgggaatc caatggccag cccgagaaca attacaagac cacacctcca     1260

gtgctggact ctgatggcag tttctttctg tattcaaggc tgaccgtgga taaaagcaga     1320

tggcaggagg gaaacgtctt ctcttgcagt gtgatgcacg aagctctgca caatcattac     1380

actcagaagt cactgagcct gtccctggga aagtgataac tcgag                     1425


<210>  49
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG4 (light chain)(mod4)

<400>  49

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr 
        35                  40                  45              


Gly Ser Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu 
    50                  55                  60                  


Val Ile Tyr Ser Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Arg Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu 
                85                  90                  95      


Glu Ser Gly Asp Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe 
            100                 105                 110         


Gly Gln Gly Thr Lys Val Gln Val Asp Ile Lys Arg Thr Val Ala Ala 
        115                 120                 125             


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
    130                 135                 140                 


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
145                 150                 155                 160 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
                165                 170                 175     


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
            180                 185                 190         


Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
        195                 200                 205             


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
    210                 215                 220                 


Phe Asn Arg Gly Glu Cys 
225                 230 


<210>  50
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG4 (light chain)(mod4)

<400>  50
ggatccgcca ccatggtcct gcagactcag gtgttcatca gtctgctgct gtggatttca       60

ggcgcctacg gagagattgt gctgactcag tctcccggca ccctgtcact gagccctgga      120

gaaaccgcca tcattagttg tcgaacatca cagtacggga gcctggcatg gtatcagcag      180

cgaccaggac aggctccccg actggtcatc tactccggct ctacacgggc agccggaatt      240

cccgaccgat tcagtgggtc aaggtggggc cctgattaca acctgactat ctccaatctg      300

gagtctggcg actttggagt gtactattgc cagcagtatg aattctttgg gcagggcacc      360

aaggtccagg tggacatcaa aagaacagtc gctgcaccaa gcgtgttcat ctttccccct      420

tcagatgagc agctgaagag tggaaccgcc tcagtggtgt gcctgctgaa caatttctac      480

ccccgggaag caaaggtcca gtggaaagtg gacaacgccc tgcagtcagg caatagccag      540

gagtccgtga cagaacagga ctctaaggat agtacttatt cactgtccaa cacactgact      600

ctgtccaaag ctgattacga gaagcacaaa gtgtatgcat gcgaggtcac ccaccagggg      660

ctgtcatcac ccgtcaccaa gtctttcaat aggggcgaat gttgataact cgag            714


<210>  51
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG2_New

<400>  51

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe 
465                 470                 475                 480 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                485                 490                 495     


Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly 
            500                 505                 510         


Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 
        515                 520                 525             


Ser Pro Gly Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly 
    530                 535                 540                 


Ser Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val 
545                 550                 555                 560 


Ile Tyr Ser Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser 
                565                 570                 575     


Gly Ser Arg Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu 
            580                 585                 590         


Ser Gly Asp Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly 
        595                 600                 605             


Gln Gly Thr Lys Val Gln Val Asp Ile Lys Arg Thr Val Ala Ala Pro 
    610                 615                 620                 


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
625                 630                 635                 640 


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
                645                 650                 655     


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
            660                 665                 670         


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn 
        675                 680                 685             


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
    690                 695                 700                 


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
705                 710                 715                 720 


Asn Arg Gly Glu Cys 
                725 


<210>  52
<211>  2199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG2_New

<400>  52
ggatccgcca ccatggattg gacatggagg attctgtttc tggtcgccgc cgccactgga       60

actcatgctc aggtgcagct ggtgcagtct ggagggcaga tgaagaaacc aggggagtct      120

atgcgaatca gttgcagggc ttcaggctac gaattcatcg actgtaccct gaactggatt      180

agactggcac ctggcaagcg accagagtgg atgggatggc tgaaacccag aggcggagcc      240

gtgaattacg ctagacctct gcagggacgg gtcactatga cccgcgacgt gtatagcgat      300

acagcttttc tggagctgcg aagcctgacc gtcgacgata cagcagtgta cttctgcact      360

aggggcaaga actgtgacta taattgggat tttgaacact gggggagagg caccccagtc      420

attgtgagct ccgcatctac aaaaggacct agcgtgttcc cactggcacc ttgcagccgg      480

tccacttctg agagtaccgc cgctctggga tgtctggtga aggattactt ccccgaacct      540

gtcacagtgt cttggaacag tggggccctg actagcggcg tccacacctt tcccgctgtg      600

ctgcagtcta gtgggctgta cagcctgtca agcgtggtca ctgtgccatc ctctaatttt      660

ggcacacaga cttatacctg caacgtggac cataagccct ccaatacaaa ggtcgataaa      720

actgtggaga gaaaatgctg cgtggaatgc cctccctgtc cagcaccacc cgtcgcagga      780

ccaagcgtgt tcctgtttcc tccaaagcca aaagacacac tgatgatcag ccggacaccc      840

gaggtcactt gcgtggtcgt ggacgtgagc cacgaggacc ccgaagtcca gttcaactgg      900

tacgtggatg gcgtcgaagt gcataatgct aagaccaaac caagggagga acagttcaac      960

tcaaccttta gagtcgtgag cgtgctgaca gtcgtgcatc aggactggct gaacggaaag     1020

gagtataagt gcaaagtgtc caataagggg ctgccagccc ccatcgagaa aaccatttct     1080

aagacaaaag gccagccacg ggaaccccag gtgtacacac tgcccccttc ccgcgaggaa     1140

atgactaaga accaggtctc tctgacctgt ctggtgaaag gcttttatcc ctctgacatt     1200

gccgtggagt gggaaagtaa tggacagcct gagaacaatt acaagaccac accacccatg     1260

ctggactcag atggaagctt ctttctgtat tccaagctga ccgtggataa atctagatgg     1320

cagcagggga acgtcttctc atgcagcgtg atgcacgagg ccctgcacaa tcattacact     1380

cagaagtccc tgtctctgag tcctgggaag cggggccgca aaaggagatc aggaagcggg     1440

gctaccaact tcagcctgct gaagcaggca ggggacgtgg aggaaaatcc tggcccaatg     1500

gtcctgcaga ctcaggtgtt catcagcctg ctgctgtgga tttccggagc atacggggag     1560

attgtgctga cccagtcacc tggaacactg tccctgtctc caggggaaac agccatcatt     1620

agctgtcgaa cttcccagta cggctctctg gcatggtatc agcagcgacc aggacaggct     1680

cctcgactgg tcatctacag tggatcaacc cgggcagccg ggattcctga ccgattcagc     1740

ggctccaggt ggggacctga ttacaacctg acaatcagta atctggagtc aggagacttt     1800

ggggtgtact attgccagca gtatgaattc tttggccagg gaacaaaggt ccaggtggac     1860

atcaaacgca ctgtcgctgc acccagcgtg ttcatttttc ctccatccga tgagcagctg     1920

aagagcggaa ccgcatccgt ggtgtgcctg ctgaacaatt tctaccctag ggaagcaaag     1980

gtccagtgga aagtggacaa cgccctgcag tccggcaatt ctcaggagag tgtgactgaa     2040

caggactcaa aggatagcac ctattccctg agtaacacac tgactctgag caaagctgat     2100

tacgagaagc acaaagtgta tgcatgcgaa gtcacccacc aggggctgag ctctccagtc     2160

actaagtctt ttaatcgggg cgaatgctga taactcgag                            2199


<210>  53
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG3_new

<400>  53

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe 
        35                  40                  45              


Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro 
    50                  55                  60                  


Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp 
                85                  90                  95      


Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu 
        115                 120                 125             


His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Leu 
225                 230                 235                 240 


Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu 
                245                 250                 255     


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys 
        275                 280                 285             


Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu 
    290                 295                 300                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
305                 310                 315                 320 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                325                 330                 335     


Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val 
            340                 345                 350         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        355                 360                 365             


Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
                405                 410                 415     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            420                 425                 430         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        435                 440                 445             


Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr 
    450                 455                 460                 


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
465                 470                 475                 480 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser 
                485                 490                 495     


Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser 
            500                 505                 510         


Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala 
        515                 520                 525             


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
    530                 535                 540                 


Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp 
545                 550                 555                 560 


Ile Ser Gly Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
                565                 570                 575     


Leu Ser Leu Ser Pro Gly Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser 
            580                 585                 590         


Gln Tyr Gly Ser Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro 
        595                 600                 605             


Arg Leu Val Ile Tyr Ser Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp 
    610                 615                 620                 


Arg Phe Ser Gly Ser Arg Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser 
625                 630                 635                 640 


Asn Leu Glu Ser Gly Asp Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu 
                645                 650                 655     


Phe Phe Gly Gln Gly Thr Lys Val Gln Val Asp Ile Lys Arg Thr Val 
            660                 665                 670         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        675                 680                 685             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    690                 695                 700                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
705                 710                 715                 720 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                725                 730                 735     


Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            740                 745                 750         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        755                 760                 765             


Lys Ser Phe Asn Arg Gly Glu Cys 
    770                 775     


<210>  54
<211>  2352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 human IgG3_new

<400>  54
ggatccgcca ccatggattg gacatggagg attctgttcc tggtcgccgc cgccacagga       60

acccatgctc aggtgcagct ggtgcagtct ggagggcaga tgaagaaacc cggcgagtca      120

atgcgaatca gctgcagggc ttccggatac gaattcatcg attgtaccct gaactggatt      180

agactggcac caggaaagcg gcccgagtgg atggggtggc tgaaaccacg cggcggagca      240

gtgaattacg ccagacccct gcagggccgg gtcacaatga ctcgcgacgt gtattcagat      300

accgcattcc tggagctgcg aagcctgact gtcgacgata ccgccgtgta cttctgcaca      360

aggggcaaaa actgtgacta caactgggat ttcgaacact ggggccgcgg aaccccagtc      420

attgtgagct ccgcatcaac aaaggggcct agcgtgtttc ctctggcccc atgcagtagg      480

tcaacaagcg ggggcactgc cgctctggga tgtctggtga aggactattt cccagagccc      540

gtcaccgtgt catggaacag cggcgccctg acatccggag tccatacttt tcccgctgtg      600

ctgcagtcta gtggactgta ctctctgtca agcgtggtca cagtcccttc ctctagtctg      660

gggacccaga catatacttg taacgtgaat cacaagccaa gcaacactaa ggtcgacaaa      720

agagtggagc tgaaaacccc tctgggcgat accacacata catgcccaag atgtcctgag      780

ccaaagtcct gcgacacgcc tccaccatgc cctcggtgtc ccgaacctaa atcttgtgat      840

acaccccctc catgcccacg atgtccagag ccaaagagct gcgacactcc ccctccatgt      900

cctcgatgtc ctgctccaga actgctggga gggccctccg tgttcctgtt tccccctaag      960

cctaaagata ccctgatgat cagtcggacc ccagaggtca catgcgtggt cgtggacgtg     1020

tcccacgagg accccgaagt ccagttcaag tggtacgtgg acggcgtcga agtgcataac     1080

gccaagacaa aacctaggga ggaacagtat aattccactt ttagagtcgt gtctgtcctg     1140

accgtgctgc accaggactg gctgaacgga aaggagtaca agtgtaaagt gtctaataag     1200

gccctgcccg ctcctatcga gaaaactatt agcaagacca aagggcagcc ccgggaacct     1260

caggtgtaca ccctgccacc ctcccgcgag gaaatgacta agaaccaggt ctctctgacc     1320

tgcctggtga aagggttcta tcccagcgat atcgctgtgg agtgggaatc aagcggccag     1380

cctgagaaca attacaatac tacccctcca atgctggact ccgatggctc tttctttctg     1440

tatagtaagc tgacagtgga caaatcaaga tggcagcagg gaaacatttt ctcctgttct     1500

gtgatgcacg aagccctgca taatcggttt acccagaaga gtctgtcact gagcccaggc     1560

aagcggggac gcaaaaggag atccgggtct ggcgctacaa acttctccct gctgaagcag     1620

gcaggcgacg tggaggaaaa tccaggacct atggtcctgc agacccaggt gttcatctct     1680

ctgctgctgt ggattagtgg ggcatacggc gaaattgtgc tgacccagtc cccagggaca     1740

ctgagtctgt cacccggcga gacagccatc atttcttgcc ggactagtca gtacggatca     1800

ctggcatggt atcagcagcg acctggacag gctccacgac tggtcatcta cagcgggtcc     1860

actagggcag ccggcattcc tgaccgattc tctggaagta ggtgggggcc tgattacaac     1920

ctgaccatca gcaatctgga gtccggggac tttggcgtgt actattgtca gcagtatgaa     1980

ttctttggac aggggactaa ggtccaggtg gatatcaaac gcaccgtcgc tgcacccagc     2040

gtgttcatct ttccccctag tgacgaacag ctgaagtctg gcaccgccag tgtcgtgtgc     2100

ctgctgaaca acttctaccc tagggaggca aaggtccagt ggaaagtgga taacgccctg     2160

cagagtggaa attcacagga gagcgtgaca gaacaggact ccaaggattc tacttatagt     2220

ctgtccaaca ccctgacact gagcaaagct gactacgaga agcacaaagt gtatgcatgt     2280

gaggtcaccc accaggggct gagctcacca gtcacaaaat ccttcaatag gggagaatgt     2340

tgataactcg ag                                                         2352


<210>  55
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT145 Heavy Chain

<400>  55

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asn Ser Phe 
        35                  40                  45              


Ser Asn His Asp Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Met Ser His Glu Gly Asp Lys Thr Gly Leu Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Ser Gly Ala Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Arg Gly Leu Thr Ala Asp Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Leu Thr Gly Ser Lys His Arg Leu Arg Asp Tyr Phe Leu 
        115                 120                 125             


Tyr Asn Glu Tyr Gly Pro Asn Tyr Glu Glu Trp Gly Asp Tyr Leu Ala 
    130                 135                 140                 


Thr Leu Asp Val Trp Gly His Gly Thr Ala Val Thr Val Ser Ser Ala 
145                 150                 155                 160 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
                165                 170                 175     


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            180                 185                 190         


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        195                 200                 205             


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    210                 215                 220                 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
225                 230                 235                 240 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
                245                 250                 255     


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        275                 280                 285             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
305                 310                 315                 320 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                325                 330                 335     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            340                 345                 350         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        355                 360                 365             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    370                 375                 380                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
385                 390                 395                 400 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                405                 410                 415     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            420                 425                 430         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        435                 440                 445             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    450                 455                 460                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
465                 470                 475                 480 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 


<210>  56
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT145 Heavy Chain

<400>  56
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctcag       60

gtgcagctgg tgcagtcagg ggccgaagtg aagaagcccg gcagctccgt gaaggtgtcc      120

tgcaaggcct ctggcaactc cttctctaat cacgacgtgc actgggtgag gcaggcaacc      180

ggacagggcc tggagtggat gggctggatg tcccacgagg gcgacaagac aggcctggca      240

cagaagtttc agggccgggt gaccatcaca cgcgattccg gcgcctctac cgtgtatatg      300

gagctgagag gcctgaccgc cgacgataca gccatctact attgcctgac aggcagcaag      360

cacaggctga gagactactt cctgtataac gagtacggcc ctaattatga ggagtggggc      420

gactacctgg ccaccctgga cgtgtgggga cacggaaccg cagtgacagt gtctagcgcc      480

agcacaaagg gcccatccgt gtttccactg gcaccctcct ctaagagcac ctccggcggc      540

acagccgccc tgggctgtct ggtgaaggat tacttcccag agccagtgac cgtgagctgg      600

aactccggcg ccctgacctc cggagtgcac acatttccag ccgtgctgca gagctccggc      660

ctgtatagcc tgtctagcgt ggtgaccgtg ccctcctcta gcctgggcac ccagacatac      720

atctgcaacg tgaatcacaa gccatccaat acaaaggtgg acaagaaggt ggagcccaag      780

tcttgtgata agacccacac atgccctccc tgtcctgcac cagagctgct gggcggccca      840

tccgtgttcc tgtttccacc caagcctaag gacaccctga tgatcagccg gaccccagag      900

gtgacatgcg tggtggtgga cgtgtcccac gaggaccccg aggtgaagtt caactggtac      960

gtggatggcg tggaggtgca caatgccaag accaagccta gggaggagca gtataactct     1020

acctacagag tggtgagcgt gctgacagtg ctgcaccagg actggctgaa cggcaaggag     1080

tacaagtgca aggtgtctaa taaggccctg cccgccccta tcgagaagac catcagcaag     1140

gcaaagggac agcctcggga gccacaggtg tatacactgc ctccatctcg cgacgagctg     1200

accaagaacc aggtgagcct gacatgtctg gtgaagggct tctaccctag cgatatcgcc     1260

gtggagtggg agtccaatgg ccagccagag aacaattata agaccacacc ccctgtgctg     1320

gactctgatg gcagcttctt tctgtactcc aagctgaccg tggataagtc tcgctggcag     1380

cagggcaacg tgttcagctg tagcgtgatg cacgaagccc tgcacaacca ctacacccag     1440

aaaagcctgt cactgagccc cggaaaa                                         1467


<210>  57
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT145 Kappa Light Chain

<400>  57

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Glu Val Val Ile Thr Gln Ser Pro Leu Phe Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Ala Ala Ser Leu Ser Cys Lys Cys Ser His Ser 
        35                  40                  45              


Leu Gln His Ser Thr Gly Ala Asn Tyr Leu Ala Trp Tyr Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Thr Pro Arg Leu Leu Ile His Leu Ala Thr His Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ser Asp Asp Val Gly Thr Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Leu His Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  58
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT145 Kappa Light Chain

<400>  58
atggtgctgc agacccaggt gttcatttca ctgctgctgt ggatttcagg agcctacgga       60

gaagtcgtca ttacccagtc ccctctgttc ctgccagtga ccccaggaga ggcagcatct      120

ctgagctgca agtgttccca ctctctgcag cacagcacag gcgccaacta cctggcctgg      180

tatctgcaga ggcctggcca gaccccaaga ctgctgatcc acctggcaac acacagggca      240

tccggagtgc cagaccgctt cagcggctcc ggctctggaa ccgacttcac cctgaagatc      300

agcagggtgg agtccgacga tgtgggcacc tactattgca tgcagggcct gcactctccc      360

tggaccttcg gccagggcac aaaggtggag atcaagagga ccgtggcagc accttccgtg      420

ttcatctttc ccccttctga cgagcagctg aagtctggca cagccagcgt ggtgtgcctg      480

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggataa cgccctgcag      540

agcggcaatt cccaggagtc tgtgaccgag caggacagca aggattccac atattctctg      600

agctccaccc tgacactgag caaggccgac tacgagaagc acaaggtgta tgcctgcgag      660

gtcacccatc aggggctgtc aagtccagtc acaaagtcct tcaatagggg cgaatgc         717


<210>  59
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT151 Heavy Chain

<400>  59

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Arg Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Lys Ser Val Arg Leu Ser Cys Val Val Ser Asp Phe Pro Phe 
        35                  40                  45              


Ser Lys Tyr Pro Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ala Ile Ser Gly Asp Ala Trp His Val Val Tyr Ser 
65                  70                  75                  80  


Asn Ser Val Gln Gly Arg Phe Leu Val Ser Arg Asp Asn Val Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Arg Cys Ala Arg Met Phe Gln Glu Ser Gly Pro Pro Arg Leu Asp 
        115                 120                 125             


Arg Trp Ser Gly Arg Asn Tyr Tyr Tyr Tyr Ser Gly Met Asp Val Trp 
    130                 135                 140                 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Lys 
                


<210>  60
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT151 Heavy Chain

<400>  60
atggactgga cttggcgcat tctgtttctg gtcgcagccg caaccgggac tcacgctcgg       60

gtgcagctgg tcgaatcagg aggaggagtg gtgcagccag gcaagagcgt gcggctgtcc      120

tgcgtggtgt ctgacttccc cttcagcaag tacccaatgt attgggtgcg ccaggcacca      180

ggcaagggcc tggagtgggt ggcagcaatc tccggcgatg catggcacgt ggtgtactct      240

aacagcgtgc agggcaggtt cctggtgagc agagacaacg tgaagaatac cctgtacctg      300

gagatgaatt ccctgaagat cgaggataca gccgtgtata ggtgcgccag aatgtttcag      360

gagagcggcc ctcccaggct ggacaggtgg agcggaagga actactatta ctattccgga      420

atggacgtgt ggggacaggg aaccacagtg accgtgagct ccgccagcac aaagggccct      480

tccgtgttcc ctctggcccc atctagcaag tccacctctg gcggcacagc cgccctgggc      540

tgtctggtga aggactactt ccctgagcca gtgaccgtgt cttggaacag cggcgccctg      600

acctctggag tgcacacatt tcccgccgtg ctgcagtcct ctggcctgta ctccctgagc      660

tccgtggtga ccgtgccttc tagctccctg ggcacccaga catatatctg caacgtgaat      720

cacaagccca gcaatacaaa ggtggacaag aaggtggagc ctaagtcctg tgataagacc      780

cacacatgcc caccctgtcc agcacctgag ctgctgggcg gccctagcgt gttcctgttt      840

cctccaaagc caaaggacac cctgatgatc tctagaaccc ctgaggtgac atgcgtggtg      900

gtggacgtga gccacgagga ccccgaggtg aagtttaact ggtacgtgga tggcgtggag      960

gtgcacaatg ccaagacaaa gccccgggag gagcagtaca actctaccta tcgcgtggtg     1020

agcgtgctga cagtgctgca ccaggactgg ctgaacggca aggagtataa gtgcaaggtg     1080

tccaataagg ccctgccagc ccccatcgag aagaccatct ctaaggcaaa gggacagccc     1140

agggagcctc aggtgtacac actgccccct tccagagacg agctgaccaa gaaccaggtg     1200

tctctgacat gtctggtgaa gggcttctat ccatctgata tcgccgtgga gtgggagagc     1260

aatggccagc ccgagaacaa ttacaagacc acaccacccg tgctggactc cgatggctct     1320

ttctttctgt attccaagct gaccgtggat aagtctaggt ggcagcaggg caacgtgttc     1380

agctgttccg tgatgcacga agcactgcac aaccattaca cccagaagag cctgagcctg     1440

agccccggca ag                                                         1452


<210>  61
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT151 Kappa Light Chain

<400>  61

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Glu Ser 
        35                  40                  45              


Leu Arg Gln Ser Asn Gly Lys Thr Ser Leu Tyr Trp Tyr Arg Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Val Phe Glu Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Ser Asp Arg Phe Val Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ser Lys Asp Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Asp Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  62
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT151 Kappa Light Chain

<400>  62
atggtgctgc agactcaggt gtttattagc ctgctgctgt ggatttccgg ggcctacggg       60

gacattgtga tgacccagac tcctctgtcc ctgtctgtga ccccaggaca gccagcaagc      120

atctcctgca agagctccga gagcctgagg cagtccaacg gcaagacaag cctgtactgg      180

tatagacaga agcctggcca gagcccacag ctgctggtgt tcgaggtgtc caatcggttt      240

tccggcgtgt ctgacaggtt cgtgggctct ggcagcggaa ccgacttcac cctgaggatc      300

tctagagtgg aggccgagga cgtgggcttc tactattgca tgcagtccaa ggatttcccc      360

ctgaccttcg gcggcggcac aaaggtggac ctgaagagga ccgtggcagc accttccgtg      420

ttcatctttc ccccttctga tgagcagctg aagtctggca cagccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaatt cccaggagtc tgtgaccgag caggacagca aggattccac atattctctg      600

tctagcaccc tgacactgtc caaggccgat tacgagaagc acaaggtgta tgcctgtgag      660

gtcacccacc aggggctgtc cagtccagtc acaaaatcct tcaatcgggg agaatgt         717


<210>  63
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGDM1400 Heavy Chain

<400>  63

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Ala Gln Leu Val Gln Ser Gly Pro Glu Val Arg Lys 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Pro Gly Asn Thr Leu 
        35                  40                  45              


Lys Thr Tyr Asp Leu His Trp Val Arg Ser Val Pro Gly Gln Gly Leu 
    50                  55                  60                  


Gln Trp Met Gly Trp Ile Ser His Glu Gly Asp Lys Lys Val Ile Val 
65                  70                  75                  80  


Glu Arg Phe Lys Ala Lys Val Thr Ile Asp Trp Asp Arg Ser Thr Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Gly Leu Thr Ser Gly Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Gly Ser Lys His Arg Leu Arg Asp Tyr Ala Leu 
        115                 120                 125             


Tyr Asp Asp Asp Gly Ala Leu Asn Trp Ala Val Asp Val Asp Tyr Leu 
    130                 135                 140                 


Ser Asn Leu Glu Phe Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
145                 150                 155                 160 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
                165                 170                 175     


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            180                 185                 190         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        195                 200                 205             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    210                 215                 220                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
225                 230                 235                 240 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                245                 250                 255     


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            260                 265                 270         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        355                 360                 365             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
385                 390                 395                 400 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490 


<210>  64
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGDM1400 Heavy Chain

<400>  64
atggattgga catggaggat tctgtttctg gtcgccgccg caaccggaac tcacgctcag       60

gctcagctgg tgcagtctgg acctgaagtg aggaagccag gcacctccgt gaaggtgtct      120

tgcaaggccc ccggcaacac cctgaagaca tacgatctgc actgggtgag atctgtgcca      180

ggacagggcc tgcagtggat gggatggatc agccacgagg gcgacaagaa agtgatcgtg      240

gagaggttca aggccaaggt gaccatcgat tgggacagat ccaccaatac agcctacctg      300

cagctgagcg gcctgacctc cggcgataca gccgtgtact attgcgccaa gggcagcaag      360

cacaggctga gagactacgc cctgtatgac gatgacggcg ccctgaactg ggccgtggat      420

gtggactatc tgtccaatct ggagttctgg ggacagggaa ccgcagtgac agtgagctcc      480

gcctctacca agggccctag cgtgtttcca ctggccccct ctagcaagtc taccagcggc      540

ggcacagccg ccctgggatg tctggtgaag gactacttcc cagagcccgt gacagtgagc      600

tggaactccg gcgccctgac ctctggagtg cacacatttc ctgccgtgct gcagtcctct      660

ggcctgtaca gcctgagctc cgtggtgacc gtgccatcta gctccctggg cacccagaca      720

tatatctgca acgtgaatca caagcctagc aatacaaagg tggataagaa ggtggagcca      780

aagtcctgtg acaagaccca cacatgccct ccctgtcctg caccagagct gctgggcggc      840

ccaagcgtgt tcctgtttcc acccaagcct aaggataccc tgatgatctc ccggacccca      900

gaggtgacat gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gtttaactgg      960

tacgtggacg gcgtggaggt gcacaatgcc aagacaaagc cccgggagga gcagtacaac     1020

tccacctatc gcgtggtgtc tgtgctgaca gtgctgcacc aggattggct gaacggcaag     1080

gagtataagt gcaaggtgag caataaggcc ctgcccgccc ctatcgagaa gaccatctcc     1140

aaggcaaagg gacagcctcg ggagccacag gtgtacacac tgcctccatc ccgcgatgag     1200

ctgaccaaga accaggtgtc tctgacatgt ctggtgaagg gcttctatcc ctctgacatc     1260

gccgtggagt gggagagcaa tggccagcct gagaacaatt acaagaccac accccctgtg     1320

ctggattctg acggcagctt ctttctgtat agcaagctga ccgtggacaa gtcccgctgg     1380

cagcagggca acgtgttcag ctgttctgtg atgcacgaag cactgcacaa ccactacacc     1440

cagaagtcac tgtcactgtc accaggaaaa                                      1470


<210>  65
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGDM1400 Kappa Light Chain

<400>  65

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Phe Val Leu Thr Gln Ser Pro His Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Glu Ser Ala Ser Ile Ser Cys Lys Ser Ser His Ser 
        35                  40                  45              


Leu Ile His Gly Asp Arg Asn Asn Tyr Leu Ala Trp Tyr Val Gln Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Gln Leu Leu Ile Tyr Leu Ala Ser Ser Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Asp Lys Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Thr Glu Asp Val Gly Thr Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Arg Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  66
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGDM1400 Kappa Light Chain

<400>  66
atggtgctgc agacccaggt gttcatttca ctgctgctgt ggatttccgg ggcatacggg       60

gacttcgtgc tgactcagag ccctcatagc ctgtccgtga ccccaggaga gtctgccagc      120

atctcctgca agagctccca cagcctgatc cacggcgacc ggaacaatta cctggcctgg      180

tacgtgcaga agccaggccg cagcccccag ctgctgatct acctggcctc tagcagggcc      240

tccggagtgc ctgacagatt ctctggcagc ggctccgaca aggacttcac cctgaagatc      300

tctagggtgg agacagagga tgtgggcaca tactattgca tgcagggcag agagtcccct      360

tggaccttcg gccagggcac aaaggtggac atcaagagga ccgtggcagc accatccgtg      420

ttcatctttc ccccttctga tgagcagctg aagtctggca cagccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

tctggcaata gccaggagtc cgtgaccgag caggactcta aggatagcac atattccctg      600

tcctctaccc tgacactgtc caaggccgat tacgagaagc acaaggtgta tgcctgtgag      660

gtcacccacc aggggctgtc cagtcccgtc acaaagtcct tcaatagggg cgaatgc         717


<210>  67
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A21 Heavy Chain

<400>  67

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Ser Gln His Leu Val Gln Ser Gly Thr Gln Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Val Ser Cys Gln Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Ile Leu His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Leu Ile Lys Pro Val Phe Gly Ala Val Asn Tyr Ala 
65                  70                  75                  80  


Arg Gln Phe Gln Gly Arg Ile Gln Leu Thr Arg Asp Ile Tyr Arg Glu 
                85                  90                  95      


Ile Ala Phe Leu Asp Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Glu Ser Gly Asp Asp Leu Lys Trp His Leu 
        115                 120                 125             


His Pro Trp Gly Gln Gly Thr Gln Val Ile Val Ser Pro Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  68
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12A21 Heavy Chain

<400>  68
atggattgga catggcgcat tctgtttctg gtcgcagccg ctactggaac ccacgcatca       60

cagcatctgg tgcagtctgg aactcaggtg aagaagccag gagcatccgt gcgggtgtct      120

tgccaggcaa gcggctacac cttcacaaac tatatcctgc actggtggag gcaggcacca      180

ggacagggcc tggagtggat gggcctgatc aagcccgtgt tcggcgccgt gaattacgcc      240

cggcagtttc agggccgcat ccagctgacc agggacatct atagagagat cgcctttctg      300

gatctgtccg gcctgcggtc tgacgataca gccgtgtact attgcgcccg cgacgagagc      360

ggcgacgatc tgaagtggca cctgcaccct tggggacagg gaacccaggt catcgtgagc      420

ccagcatcta caaagggacc ttccgtgttc ccactggcac ccagctccaa gagcacctcc      480

ggcggcacag ccgccctggg ctgtctggtg aaggattact tcccagagcc agtgaccgtg      540

agctggaact ccggcgccct gacctctgga gtgcacacat ttcccgccgt gctgcagtct      600

agcggcctgt actccctgtc ctctgtggtg accgtgccta gctcctctct gggcacccag      660

acatatatct gcaacgtgaa tcacaagcct tctaatacaa aggtggacaa gaaggtggag      720

ccaaagagct gtgataagac ccacacatgc cctccctgtc ctgcaccaga gctgctgggc      780

ggcccaagcg tgttcctgtt tccacccaag cccaaggaca ccctgatgat ctccaggacc      840

cctgaggtga catgcgtggt ggtggacgtg tctcacgagg accccgaggt gaagtttaac      900

tggtacgtgg atggcgtgga ggtgcacaat gccaagacaa agcccaggga ggagcagtac      960

aacagcacct atagagtggt gtccgtgctg acagtgctgc accaggactg gctgaacggc     1020

aaggagtata agtgcaaggt gagcaataag gccctgcccg cccctatcga gaagaccatc     1080

tccaaggcca agggccagcc tagggagcca caggtgtaca cactgcctcc aagcagagac     1140

gagctgacca agaaccaggt gtccctgaca tgtctggtga agggctttta tccatccgat     1200

atcgccgtgg agtgggagtc taatggccag cccgagaaca attacaagac cacaccccct     1260

gtgctggact ctgatggcag cttctttctg tattctaagc tgaccgtgga taagagcaga     1320

tggcagcagg gcaacgtgtt cagctgtagc gtgatgcacg aagcactgca caaccactac     1380

acccagaagt cactgtcact gagcccagga aaa                                  1413


<210>  69
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A21 Kappa Light Chain

<400>  69

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Gly Gln Gly 
        35                  40                  45              


Ile Gly Ser Ser Leu Asn Trp Tyr Gln Lys Lys Pro Gly Arg Ala Pro 
    50                  55                  60                  


Lys Leu Leu Val His Gly Ala Ser Asn Leu Gln Arg Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Phe His Thr Thr Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Asp Asp Val Ala Thr Tyr Phe Cys Ala Val Phe Gln 
            100                 105                 110         


Trp Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
        115                 120                 125             


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
    130                 135                 140                 


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
145                 150                 155                 160 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
                165                 170                 175     


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
            180                 185                 190         


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
        195                 200                 205             


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
    210                 215                 220                 


Phe Asn Arg Gly Glu Cys 
225                 230 


<210>  70
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12A21 Kappa Light Chain

<400>  70
atggtgctgc agactcaggt gtttatttca ctgctgctgt ggatttcagg agcctacggc       60

gacattcaga tgactcagag cccctcaagc ctgtccgcct ctgtgggcga ccgggtgacc      120

atcaactgcc aggcaggaca gggaatcggc agctccctga attggtacca gaagaagcca      180

ggaagggcac caaagctgct ggtgcacgga gcatccaacc tgcagagggg cgtgcccagc      240

agattcagcg gctccggctt ccacaccacc ttcaccctga caatctctag cctgcagcct      300

gacgatgtgg ccacctattt ttgcgccgtg ttccagtggt ttggccctgg caccaaggtg      360

gacatcaaga ggacagtggc cgccccatcc gtgttcatct ttcccccttc tgatgagcag      420

ctgaagtctg gcacagccag cgtggtgtgc ctgctgaaca atttctaccc ccgggaggcc      480

aaggtgcagt ggaaggtgga caacgccctg cagtctggca atagccagga gtccgtgacc      540

gagcaggact ctaaggatag cacatattcc ctgtcctcta ccctgacact gtccaaggcc      600

gattacgaga agcacaaggt gtatgcctgt gaggtcaccc accaggggct gtcaagtcca      660

gtcacaaaat ccttcaatcg gggagaatgc                                       690


<210>  71
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC3401 Heavy Chain

<400>  71

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Glu Val Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Arg Ala Phe Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Asn Ala Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Trp Ile Asn Pro His Ser Gly Asp Thr Thr Thr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Tyr Met Thr Arg Asp Lys Ser Ile Asn 
                85                  90                  95      


Thr Ala Phe Leu Asp Val Thr Arg Leu Thr Ser Asp Asp Thr Gly Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Lys Tyr Tyr Gly Asn Glu Ala Val Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  72
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC3401 Heavy Chain

<400>  72
atggattgga catggcgcat tctgtttctg gtcgcagccg ctaccggaac ccacgctcag       60

gaagtgctgg tgcagtcagg ggccgaagtg aagaagcccg gcgcctccgt gaaggtgtct      120

tgcagggcct tcggctacac cttcaccggc aacgcactgc actgggtgag acaggcacct      180

ggacagggcc tggagtggct gggatggatc aatccacact ctggcgacac cacaaccagc      240

cagaagttcc agggcagggt gtatatgaca agagacaagt ctatcaacac cgcctttctg      300

gatgtgacac ggctgaccag cgacgataca ggcatctact attgcgcccg cgacaagtac      360

tatggcaatg aggcagtggg aatggacgtg tggggacagg gcacatccgt gaccgtgagc      420

tccgccagca ccaagggacc ttccgtgttc ccactggcac cctctagcaa gtctacaagc      480

ggcggcaccg ccgccctggg atgtctggtg aaggattact tcccagagcc agtgaccgtg      540

agctggaact ccggcgccct gacatctggc gtgcacacct ttcctgccgt gctgcagtcc      600

tctggcctgt acagcctgag ctccgtggtg acagtgccat ctagctccct gggcacacag      660

acctatatct gcaacgtgaa tcacaagcca agcaatacca aggtggacaa gaaggtggag      720

cccaagtcct gtgataagac acacacctgc cctccctgtc ctgcaccaga gctgctgggc      780

ggcccaagcg tgttcctgtt tccacccaag cctaaggaca cactgatgat ctcccggaca      840

ccagaggtga cctgcgtggt ggtggacgtg tctcacgagg accccgaggt gaagtttaac      900

tggtacgtgg atggcgtgga ggtgcacaat gccaagacca agccccggga ggagcagtac      960

aactccacat atcgcgtggt gtctgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtata agtgcaaggt gagcaataag gccctgcccg cccctatcga gaagacaatc     1080

tccaaggcca agggccagcc tagggagcca caggtgtaca ccctgcctcc atccagagac     1140

gagctgacaa agaaccaggt gtctctgacc tgtctggtga agggcttcta tccctctgat     1200

atcgccgtgg agtgggagag caatggccag cctgagaaca attacaagac aacccctccc     1260

gtgctggact ctgatggcag cttctttctg tatagcaagc tgaccgtgga taagtcccgc     1320

tggcagcagg gcaacgtgtt cagctgttct gtgatgcacg aagcactgca caaccactac     1380

acccagaagt cactgtcact gagcccagga aag                                  1413


<210>  73
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC3401 Kappa Light Chain

<400>  73

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 
            20                  25                  30          


Val Gly Asp Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Arg 
        35                  40                  45              


Asn Glu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu 
    50                  55                  60                  


Leu Ile Tyr Tyr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Ala Thr Gly Ser Gly Thr His Phe Thr Leu Thr Val Ser Ser Leu 
                85                  90                  95      


Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln His Met Ser Ser Tyr 
            100                 105                 110         


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  74
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC3401 Kappa Light Chain

<400>  74
atggtgctgc agacccaggt gtttatttca ctgctgctgt ggattagcgg agcctacggc       60

cagctgaccc agagcccaag tttcctgagc gcctccgtgg gcgacaaggt gaccatcaca      120

tgcagggcct cccagggcgt gagaaacgag ctggcctggt accagcagaa gccaggcaag      180

gcccccaatc tgctgatcta ctatgcctcc accctgcagt ctggagtgcc ctctaggttc      240

agcgccaccg gctctggcac acactttacc ctgacagtga gctccctgca gcctgaggat      300

ttcgccacat acttttgcca gcacatgtct agctatccac tgaccttcgg cggcggcaca      360

aaggtggaga tcaagaggac cgtggcagca ccaagcgtgt tcatctttcc ccctagcgac      420

gagcagctga agagcggcac agcctccgtg gtgtgcctgc tgaacaactt ctaccctcgc      480

gaggccaagg tgcagtggaa ggtggataac gccctgcagt ccggcaattc tcaggagagc      540

gtgaccgagc aggactccaa ggattctaca tatagcctgt cctctaccct gacactgagc      600

aaggccgact acgagaagca caaggtgtat gcctgtgagg tcacccacca ggggctgagc      660

agtccagtca ccaagtcctt caatcggggc gaatgt                                696


<210>  75
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IOMA Heavy Chain

<400>  75

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Ala Gln Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Thr Val Ser Cys Thr Ala Ser Gly Tyr Lys Phe 
        35                  40                  45              


Thr Gly Tyr His Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Phe Arg Gly Ala Val Lys Tyr Pro 
65                  70                  75                  80  


Gln Asn Phe Arg Gly Arg Val Ser Met Thr Arg Asp Thr Ser Met Glu 
                85                  90                  95      


Ile Phe Tyr Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Met Phe Asp Ser Ser Ala Asp Trp Ser Pro 
        115                 120                 125             


Trp Arg Gly Met Val Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  76
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IOMA Heavy Chain

<400>  76
atggactgga catggagaat cctgttcctg gtcgcagcag caaccggcac ccacgcagaa       60

gtgcagctgg tcgaaagcgg ggctcaggtg aagaagccag gagcaagcgt gaccgtgtcc      120

tgcacagcat ctggctacaa gttcaccggc tatcacatgc actgggtgcg gcaggcacct      180

ggaaggggcc tggagtggat gggatggatc aaccccttca ggggcgccgt gaagtaccct      240

cagaacttca ggggcagagt gtccatgacc agggacacat ctatggagat cttctatatg      300

gagctgagca gactgacctc cgacgataca gccgtgtact attgcgcccg ggagatgttt      360

gacagctccg ccgattggag cccctggagg ggaatggtgg catggggaca gggcaccctg      420

gtgacagtgt ctagcgcctc taccaagggc cctagcgtgt ttccactggc cccctcctct      480

aagtccacct ctggcggcac agccgccctg ggctgtctgg tgaaggatta cttcccagag      540

cccgtgacag tgtcttggaa cagcggcgcc ctgaccagcg gagtgcacac atttcctgcc      600

gtgctgcaga gctccggcct gtactccctg tctagcgtgg tgaccgtgcc atcctctagc      660

ctgggcaccc agacatatat ctgcaacgtg aatcacaagc cttctaatac aaaggtggac      720

aagaaggtgg agccaaagag ctgtgataag acccacacat gccctccctg tcctgcacca      780

gagctgctgg gcggcccatc cgtgttcctg tttccaccca agcccaagga caccctgatg      840

atctccagga ccccagaggt gacatgcgtg gtggtggacg tgtctcacga ggaccccgag      900

gtgaagttca actggtacgt ggatggcgtg gaggtgcaca atgccaagac aaagcccagg      960

gaggagcagt acaacagcac ctatagagtg gtgtccgtgc tgacagtgct gcaccaggac     1020

tggctgaacg gcaaggagta taagtgcaag gtgagcaata aggccctgcc cgcccctatc     1080

gagaagacca tctccaaggc aaagggacag cctcgggagc cacaggtgta cacactgcct     1140

ccaagccgcg acgagctgac caagaaccag gtgtccctga catgtctggt gaagggcttc     1200

tatccctccg atatcgccgt ggagtgggag tctaatggcc agcctgagaa caattacaag     1260

accacacccc ctgtgctgga ctccgatggc tctttctttc tgtattctaa gctgaccgtg     1320

gataagagca gatggcagca gggcaacgtg ttcagctgtt ccgtgatgca cgaagcactg     1380

cacaaccatt acactcagaa gtcactgtca ctgtcaccag ggaag                     1425


<210>  77
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IOMA Lambda Light Chain

<400>  77

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ala Gly Ser Ser Arg Asp 
        35                  40                  45              


Val Gly Gly Phe Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Ile Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Ser Ser Arg Phe Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      


Ile Ser Gly Leu Gln Glu Glu Asp Glu Ala His Tyr Tyr Cys Tyr Ser 
            100                 105                 110         


Tyr Ala Asp Gly Val Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  78
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IOMA Lambda Light Chain

<400>  78
atggcttgga cccctctgtt tctgtttctg ctgacctgtt gccccggagg aagtaattcc       60

cagtctgccc tgacccagcc tgcatcagtg tccggctctc ctggccagtc catcacaatc      120

tcttgcgcag gcagctccag ggacgtgggc ggctttgatc tggtgtcctg gtaccagcag      180

cacccaggca aggcccccaa gctgatcatc tatgaggtga acaagaggcc ctctggcatc      240

tctagcagat tcagcgcctc caagtctggc aatacagcca gcctgaccat ctccggcctg      300

caggaggagg acgaggcaca ctactattgc tactcctatg cagatggagt ggccttcggc      360

ggcggcacaa agctgaccgt gctgggacag cctaaggcag caccatccgt gacactgttt      420

cccccttcct ctgaggagct gcaggccaac aaggccaccc tggtgtgcct gatcagcgac      480

ttctacccag gagcagtgac cgtggcatgg aaggcagata gctccccagt gaaggcagga      540

gtggagacaa caaccccttc taagcagagc aacaataagt acgccgcctc tagctatctg      600

tctctgaccc ccgagcagtg gaagagccac aagagctatt cctgccaggt cacccatgaa      660

ggctcaaccg tggagaaaac agtcgcccct accgaatgct ca                         702


<210>  79
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT130 Heavy Chain

<400>  79

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ala Glu Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Glu Ser Ile 
        35                  40                  45              


Asn Thr Gly His Tyr Tyr Trp Gly Trp Val Arg Gln Val Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly His Ile His Tyr Thr Thr Ala Val Leu His 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Lys Ile Tyr Thr Leu Arg 
                85                  90                  95      


Asn Gln Ile Thr Leu Arg Leu Ser Asn Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr His Cys Val Arg Ser Gly Gly Asp Ile Leu Tyr Tyr Tyr Glu 
        115                 120                 125             


Trp Gln Lys Pro His Trp Phe Ser Pro Trp Gly Pro Gly Ile His Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
                165                 170                 175     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            180                 185                 190         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        195                 200                 205             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
    210                 215                 220                 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
225                 230                 235                 240 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  80
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT130 Heavy Chain

<400>  80
atggactgga cttggaggat tctgtttctg gtcgccgccg ctactggaac tcacgctcag       60

gtgcagctgc aggaatctgg ccccggactg gtgaagcctg ccgagacact gtccctgaca      120

tgctctgtga gcggcgagtc tatcaacacc ggccactact attggggatg ggtgcggcag      180

gtgccaggca agggcctgga gtggatcggc cacatccact ataccacagc cgtgctgcac      240

aatccttctc tgaagagccg cctgaccatc aagatctaca cactgaggaa ccagatcacc      300

ctgagactgt ctaatgtgac cgccgccgac acagccgtgt atcactgcgt gagaagcggc      360

ggcgatatcc tgtactatta cgagtggcag aagccacact ggttctcccc atggggacca      420

ggcatccacg tgaccgtgag ctccgcctct acaaagggcc ccagcgtgtt tcctctggcc      480

ccatctagca agtccacctc tggcggcaca gccgccctgg gctgtctggt gaaggactac      540

ttcccagagc ccgtgaccgt gtcctggaac tctggcgccc tgacctccgg agtgcacaca      600

tttcctgccg tgctgcagtc ctctggcctg tatagcctga gctccgtggt gaccgtgcca      660

tctagctccc tgggcaccca gacatacatc tgcaacgtga atcacaagcc ttctaataca      720

aaggtggaca agaaggtgga gccaaagagc tgtgataaga cccacacatg ccctccctgt      780

cctgcaccag agctgctggg cggcccaagc gtgttcctgt ttccacccaa gcccaaggac      840

accctgatga tctccaggac cccagaggtg acatgcgtgg tggtggacgt gtctcacgag      900

gaccccgagg tgaagttcaa ctggtacgtg gatggcgtgg aggtgcacaa tgccaagaca      960

aagccccggg aggagcagta taactccacc taccgcgtgg tgtctgtgct gacagtgctg     1020

caccaggact ggctgaacgg caaggagtac aagtgcaagg tgagcaataa ggccctgccc     1080

gcccctatcg agaagaccat ctccaaggca aagggacagc ccagggagcc tcaggtgtat     1140

acactgcctc caagcagaga cgagctgacc aagaaccagg tgtccctgac atgtctggtg     1200

aagggcttct acccctctga tatcgccgtg gagtgggaga gcaatggcca gcctgagaac     1260

aattataaga ccacaccccc tgtgctggac agcgatggct ccttctttct gtacagcaag     1320

ctgaccgtgg ataagtccag gtggcagcag ggcaacgtgt tcagctgttc cgtgatgcac     1380

gaagcactgc acaaccatta cacccagaag tccctgtcac tgtcacccgg caaa           1434


<210>  81
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT130 Lambda Light Chain

<400>  81

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly 
            20                  25                  30          


Ser Leu Gly Gln Ser Val Thr Ile Ser Cys Asn Gly Thr Ser Ser Asp 
        35                  40                  45              


Ile Gly Gly Trp Asn Phe Val Ser Trp Tyr Gln Gln Phe Pro Gly Arg 
    50                  55                  60                  


Ala Pro Arg Leu Ile Ile Phe Glu Val Asn Lys Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Gly Arg Phe Ser Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Thr 
                85                  90                  95      


Val Ser Gly Leu Gln Ser Asp Asp Glu Gly Gln Tyr Phe Cys Ser Ser 
            100                 105                 110         


Leu Phe Gly Arg Trp Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  82
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT130 Lambda Light Chain

<400>  82
atggcatgga cacccctgtt tctgttcctg ctgacctgtt gccccggagg ctcaaatagc       60

cagtctgccc tgacccagcc cccaagcgcc tccggctctc tgggccagag cgtgacaatc      120

tcctgcaacg gcaccagctc cgacatcggc ggatggaatt tcgtgagctg gtaccagcag      180

tttccaggca gggcccccag actgatcatc ttcgaggtga acaagcggcc ttccggagtg      240

ccaggccgct ttagcggctc caagtctggc aatagcgcct ccctgacagt gtctggcctg      300

cagagcgacg atgagggcca gtatttctgc tctagcctgt ttggcaggtg ggatgtggtg      360

ttcggcggcg gaacaaagct gaccgtgctg ggacagccaa aggcagcacc ttctgtgacc      420

ctgtttcccc cttcctctga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc      480

agcgacttct accctggagc agtgaccgtg gcatggaagg ccgatagctc cccagtgaag      540

gccggcgtgg agacaacaac cccctccaag cagtctaaca ataagtacgc cgcctctagc      600

tatctgtccc tgacacccga gcagtggaag tctcacaagt cttatagctg ccaggtcacc      660

catgaaggaa gcacagtgga aaaaaccgtc gcaccaaccg aatgtagc                   708


<210>  83
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT121 Heavy Chain

<400>  83

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Met Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Ala Ser Ile 
        35                  40                  45              


Ser Asp Ser Tyr Trp Ser Trp Ile Arg Arg Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Val His Lys Ser Gly Asp Thr Asn Tyr Ser Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Asn Leu Ser Leu Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Val Ser Leu Ser Leu Val Ala Ala Thr Ala Ala Asp Ser Gly Lys Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Thr Leu His Gly Arg Arg Ile Tyr Gly Ile Val Ala 
        115                 120                 125             


Phe Asn Glu Trp Phe Thr Tyr Phe Tyr Met Asp Val Trp Gly Asn Gly 
    130                 135                 140                 


Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  84
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT121 Heavy Chain

<400>  84
atggattgga catggaggat tctgtttctg gtcgccgccg ctactggaac ccacgctcag       60

atgcagctgc aggagtcagg ccccggactg gtgaagccct ccgagacact gtctctgaca      120

tgctctgtga gcggcgcctc catctctgac agctactggt cttggatcag gagaagccct      180

ggcaagggcc tggagtggat cggctacgtg cacaagtctg gcgacaccaa ctattcccca      240

tctctgaaga gcagggtgaa cctgagcctg gatacatcca agaatcaggt gagcctgtcc      300

ctggtggcag caaccgcagc agacagcggc aagtactatt gcgccagaac actgcacggc      360

aggaggatct acggcatcgt ggccttcaac gagtggttca cctactttta tatggacgtg      420

tggggcaatg gcacccaggt gacagtgagc tccgcctcca caaagggacc tagcgtgttc      480

ccactggcac cctctagcaa gtctaccagc ggcggcacag ccgccctggg atgtctggtg      540

aaggattatt tcccagagcc agtgaccgtg agctggaact ccggcgccct gaccagcgga      600

gtgcacacat ttccagccgt gctgcagtcc tctggcctgt actccctgag ctccgtggtg      660

accgtgccct ctagctccct gggcacccag acatatatct gcaacgtgaa tcacaagcca      720

tccaatacaa aggtggacaa gaaggtggag cccaagtctt gtgataagac ccacacatgc      780

cctccctgtc ctgcaccaga gctgctgggc ggcccaagcg tgttcctgtt tccacccaag      840

cctaaggaca ccctgatgat cagccggacc ccagaggtga catgcgtggt ggtggacgtg      900

tcccacgagg accccgaggt gaagttcaac tggtacgtgg atggcgtgga ggtgcacaat      960

gccaagacaa agcccaggga ggagcagtac aacagcacct atagagtggt gtccgtgctg     1020

acagtgctgc accaggactg gctgaacggc aaggagtata agtgcaaggt gtctaataag     1080

gccctgcccg cccctatcga gaagaccatc tccaaggcaa agggacagcc tcgggagcca     1140

caggtgtaca cactgcctcc aagccgcgac gagctgacca agaaccaggt gtccctgaca     1200

tgtctggtga agggcttcta tccttccgat atcgccgtgg agtgggagtc taatggccag     1260

ccagagaaca attacaagac cacaccccct gtgctggact ctgatggcag cttctttctg     1320

tattctaagc tgaccgtgga taagagccgc tggcagcagg gcaacgtgtt cagctgttct     1380

gtgatgcacg aagcactgca caaccactac actcagaagt ccctgtccct gtcccctggc     1440

aag                                                                   1443


<210>  85
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGT121 Lambda Light Chain

<400>  85

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Asp Ile Ser Val Ala Pro Gly Glu Thr Ala Arg Ile 
            20                  25                  30          


Ser Cys Gly Glu Lys Ser Leu Gly Ser Arg Ala Val Gln Trp Tyr Gln 
        35                  40                  45              


His Arg Ala Gly Gln Ala Pro Ser Leu Ile Ile Tyr Asn Asn Gln Asp 
    50                  55                  60                  


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Pro Asp Ser Pro 
65                  70                  75                  80  


Phe Gly Thr Thr Ala Thr Leu Thr Ile Thr Ser Val Glu Ala Gly Asp 
                85                  90                  95      


Glu Ala Asp Tyr Tyr Cys His Ile Trp Asp Ser Arg Val Pro Thr Lys 
            100                 105                 110         


Trp Val Phe Gly Gly Gly Thr Thr Leu Thr Val Leu Gly Gln Pro Lys 
        115                 120                 125             


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
    130                 135                 140                 


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
145                 150                 155                 160 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
                165                 170                 175     


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
            180                 185                 190         


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser 
        195                 200                 205             


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
    210                 215                 220                 


Ala Pro Thr Glu Cys Ser 
225                 230 


<210>  86
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGT121 Lambda Light Chain

<400>  86
atggcttgga ctcccctgtt cctgttcctg ctgacttgtt gccctggcgg ctctaactct       60

gacatttccg tcgctcctgg cgagactgcc aggatcagct gcggagagaa gtccctgggc      120

tctcgggccg tgcagtggta ccagcacagg gcaggacagg caccatccct gatcatctat      180

aacaatcagg acaggccttc tggcatccca gagagattca gcggctcccc agatagcccc      240

tttggcacca cagccacact gaccatcaca tccgtggagg caggcgacga ggcagattac      300

tattgccaca tctgggactc ccgggtgcct accaagtggg tgttcggcgg cggaaccaca      360

ctgacagtgc tgggacagcc aaaggcagca ccttctgtga ccctgtttcc ccctagctcc      420

gaggagctgc aggccaacaa ggccaccctg gtgtgcctga tctccgactt ctaccctgga      480

gcagtgacag tggcatggaa ggccgattct agcccagtga aggccggcgt ggagacaaca      540

acccccagca agcagtccaa caataagtac gccgcctcct cttatctgtc tctgacacca      600

gagcagtgga agagccacaa gtcttatagc tgccaggtca cccatgaagg aagcaccgtg      660

gagaaaacag tcgccccaac agaatgtagc                                       690


<210>  87
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2219 Heavy Chain

<400>  87

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Ile Gln Leu Glu Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Ser Gly Glu Ser Leu Lys Ile Ser Cys Gln Thr Ser Gly Tyr Ser Phe 
        35                  40                  45              


Ser Asp Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Ile Phe Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser 
65                  70                  75                  80  


Pro Ser Phe Glu Gly Gln Val Thr Met Ser Ala Asp Arg Ser Thr Asn 
                85                  90                  95      


Thr Ala His Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Tyr Glu Asp Ser Gly Ala Asp 
        115                 120                 125             


Ala Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  88
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2219 Heavy Chain

<400>  88
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctgag       60

attcagctgg agcagagtgg agcagaagtc aagaagagcg gggagagcct gaagattagt      120

tgccagacaa gcggatacag tttctctgac tactggatcg gatgggtgcg gcagatgcca      180

ggcaagggcc tggagtggat gggcatcttc taccccggcg actctgatag caggtattcc      240

ccttcttttg agggccaggt gaccatgagc gccgatagat ccaccaacac agcccacctg      300

cagtggagct ccctgaagcc ctccgacaca gccctgtact attgcgcaag gctgggcggc      360

gattatgagg acagcggagc cgacgccttt gatttttggg ggcaggggac tctggtgacc      420

gtgagcagcg ccagcacaaa gggcccatcc gtgtttccac tggcaccctc ctctaagagc      480

acctccggcg gcacagccgc cctgggctgt ctggtgaagg attacttccc agagccagtg      540

accgtgagct ggaactccgg cgccctgacc tccggagtgc acacatttcc agccgtgctg      600

cagagctccg gcctgtatag cctgtctagc gtggtgaccg tgccctcctc tagcctgggc      660

acccagacat acatctgcaa cgtgaatcac aagccatcca atacaaaggt ggacaagaag      720

gtggagccca agtcttgtga taagacccac acatgccctc cctgtcctgc accagagctg      780

ctgggcggcc catccgtgtt cctgtttcca cccaagccta aggacaccct gatgatcagc      840

cggaccccag aggtgacatg cgtggtggtg gacgtgtccc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggatgg cgtggaggtg cacaatgcca agaccaagcc tagggaggag      960

cagtataact ctacctacag agtggtgagc gtgctgacag tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgtct aataaggccc tgcccgcccc tatcgagaag     1080

accatcagca aggcaaaggg acagcctcgg gagccacagg tgtatacact gcctccatct     1140

cgcgacgagc tgaccaagaa ccaggtgagc ctgacatgtc tggtgaaggg cttctaccct     1200

agcgatatcg ccgtggagtg ggagtccaat ggccagccag agaacaatta taagaccaca     1260

ccccctgtgc tggactctga tggcagcttc tttctgtact ccaagctgac cgtggataag     1320

tctcgctggc agcagggcaa cgtgttcagc tgtagcgtga tgcacgaagc cctgcacaac     1380

cactacaccc agaaaagcct gtcactgagc cccggaaaa                            1419


<210>  89
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2219 Lambda Light Chain

<400>  89

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly 
            20                  25                  30          


Thr Pro Gly Gln Arg Ile Ser Ile Ser Cys Ser Gly Thr Ser Ser Asn 
        35                  40                  45              


Val Glu Asn Asn Tyr Val Tyr Trp Tyr Gln His Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Arg Asn Asp His Arg Ser Ser Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Ser Gly Leu Arg Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ala Trp 
            100                 105                 110         


Asp Asp Ser Arg Gly Gly Pro Asp Trp Val Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
                165                 170                 175     


Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys 
            180                 185                 190         


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
        195                 200                 205             


Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu 
    210                 215                 220                 


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235             


<210>  90
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2219 Lambda Light Chain

<400>  90
atggcttgga cccctctgtt tctgtttctg ctgacctgtt gccccggagg aagtaattcc       60

cagtccgtcc tgacccagcc tccctctgcc agtggaacac ccggccagcg aatctctatc      120

tcctgtagtg gaacttcatc taatgtcgag aacaattacg tgtattggta ccagcacctg      180

ccaggaaccg cacctaagct gctgatctat aggaacgacc acagaagctc cggcatccca      240

gatcggttct ctgccagcaa gtccggcaca tctgccagcc tggcaatctc cggcctgcgc      300

cccgaggacg agggcgatta ctattgcgcc gcctgggatg attccagagg aggaccagat      360

tgggtgttcg gcggcgggac taaactgacc gtgctgggac agcctaaggc agcaccatcc      420

gtgacactgt ttcccccttc ctctgaggag ctgcaggcca acaaggccac cctggtgtgc      480

ctgatcagcg acttctaccc aggagcagtg accgtggcat ggaaggcaga tagctcccca      540

gtgaaggcag gagtggagac aacaacccct tctaagcaga gcaacaataa gtacgccgcc      600

tctagctatc tgtctctgac ccccgagcag tggaagagcc acaagagcta ttcctgccag      660

gtcacccatg aaggctcaac cgtggagaaa acagtcgccc ctaccgaatg ctca            714


<210>  91
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3074 Heavy Chain

<400>  91

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Gly Phe His Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Tyr Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Ser Met Ser Val Asp Thr Ser Arg Asn Gln 
                85                  90                  95      


Phe Ser Leu Glu Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Phe Gly Glu Tyr His Tyr Asp Gly Arg Gly Phe 
        115                 120                 125             


Gln Cys Glu Gly Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  92
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3074 Heavy Chain

<400>  92
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctcag       60

gtgcagctgc aggaaagcgg gcctggactg gtgaagccta gtgaaactct gagcctgact      120

tgtaccgtga gcggaggaag cattagcggc ttccactggt cctggatcag gcagccccct      180

ggcaagggcc tggagtacat cggctatatc tactattctg gcagcacctc ctacaacccc      240

tccctgaagt ctagggtgtc tatgagcgtg gacacatcta gaaatcagtt cagcctggag      300

ctgagctccg tgaccgcagc agatacagcc gtgtactatt gcgcccggga ctttggcgag      360

taccactatg atggccgcgg ctttcagtgc gagggctttg atctgtgggg gcagggaact      420

ctggtgaccg tgagcagcgc cagcacaaag ggcccatccg tgtttccact ggcaccctcc      480

tctaagagca cctccggcgg cacagccgcc ctgggctgtc tggtgaagga ttacttccca      540

gagccagtga ccgtgagctg gaactccggc gccctgacct ccggagtgca cacatttcca      600

gccgtgctgc agagctccgg cctgtatagc ctgtctagcg tggtgaccgt gccctcctct      660

agcctgggca cccagacata catctgcaac gtgaatcaca agccatccaa tacaaaggtg      720

gacaagaagg tggagcccaa gtcttgtgat aagacccaca catgccctcc ctgtcctgca      780

ccagagctgc tgggcggccc atccgtgttc ctgtttccac ccaagcctaa ggacaccctg      840

atgatcagcc ggaccccaga ggtgacatgc gtggtggtgg acgtgtccca cgaggacccc      900

gaggtgaagt tcaactggta cgtggatggc gtggaggtgc acaatgccaa gaccaagcct      960

agggaggagc agtataactc tacctacaga gtggtgagcg tgctgacagt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgtcta ataaggccct gcccgcccct     1080

atcgagaaga ccatcagcaa ggcaaaggga cagcctcggg agccacaggt gtatacactg     1140

cctccatctc gcgacgagct gaccaagaac caggtgagcc tgacatgtct ggtgaagggc     1200

ttctacccta gcgatatcgc cgtggagtgg gagtccaatg gccagccaga gaacaattat     1260

aagaccacac cccctgtgct ggactctgat ggcagcttct ttctgtactc caagctgacc     1320

gtggataagt ctcgctggca gcagggcaac gtgttcagct gtagcgtgat gcacgaagcc     1380

ctgcacaacc actacaccca gaaaagcctg tcactgagcc ccggaaaa                  1428


<210>  93
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3074 Lambda Light Chain

<400>  93

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala 
            20                  25                  30          


Ala Pro Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn 
        35                  40                  45              


Ile Gly Asn Asn Met Val Ser Trp Tyr Gln Gln His Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Glu Asn Ser Lys Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Thr Leu Gly Ile 
                85                  90                  95      


Ile Gly Leu Gln Thr Gly Asp Glu Ala Glu Tyr Tyr Cys Ala Thr Trp 
            100                 105                 110         


Asp Gly Ser Leu Arg Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  94
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3074 Lambda Light Chain

<400>  94
atggcttgga cccctctgtt tctgtttctg ctgacctgtt gccccggagg aagtaattcc       60

cagagcgtcc tgactcagcc tccaagcgtg tccgcagccc ctgggcagaa ggtgaccatt      120

agttgtagcg gcagcagcag caatatcggc aacaatatgg tgtcttggta ccagcagcac      180

ccaggaaccg cacctaagct gctgatctat gagaacagca agaggccatc cggcatcccc      240

gacaggttca gcggctccag atctggcacc agcgccacac tgggcatcat cggcctgcag      300

acaggcgatg aggccgagta ctattgcgct acttgggatg ggagcctgcg gaccgtcttt      360

gggggaggaa ctaaactgac tgtgctggga cagcctaagg cagcaccatc cgtgacactg      420

tttccccctt cctctgagga gctgcaggcc aacaaggcca ccctggtgtg cctgatcagc      480

gacttctacc caggagcagt gaccgtggca tggaaggcag atagctcccc agtgaaggca      540

ggagtggaga caacaacccc ttctaagcag agcaacaata agtacgccgc ctctagctat      600

ctgtctctga cccccgagca gtggaagagc cacaagagct attcctgcca ggtcacccat      660

gaaggctcaa ccgtggagaa aacagtcgcc cctaccgaat gctca                      705


<210>  95
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4028 Heavy Chain

<400>  95

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Ser Ser Tyr Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Phe Ile Tyr Pro Ala Asp Ser Asp Thr Arg Tyr Ser 
65                  70                  75                  80  


Pro Ser Phe Gln Gly Gln Gly Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ile Leu Gly Phe Trp Gly Ala Asn Arg Gly Gly Gly 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Ile Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  96
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4028 Heavy Chain

<400>  96
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctgaa       60

gtgcagctgg tgcagagcgg agccgaggtc aagaagcctg gcgaaagcct gaaaatctca      120

tgtaaagcaa gcggatactc attcagctcc tactggatcg catgggtgag gcagatgcca      180

ggcaagggcc tggagtggat gggcttcatc taccccgccg actctgatac cagatattcc      240

ccttcttttc agggccaggg caccatcagc gccgacaaga gcatctccac agcctatctg      300

cagtggtcta gcctgaaggc ctccgataca gccatgtact attgcgccat cctgggcttc      360

tggggcgcca atcggggcgg aggcgggatg gatgtctggg ggcagggaac caccgtcatt      420

gtcagcagtg ccagcacaaa gggcccatcc gtgtttccac tggcaccctc ctctaagagc      480

acctccggcg gcacagccgc cctgggctgt ctggtgaagg attacttccc agagccagtg      540

accgtgagct ggaactccgg cgccctgacc tccggagtgc acacatttcc agccgtgctg      600

cagagctccg gcctgtatag cctgtctagc gtggtgaccg tgccctcctc tagcctgggc      660

acccagacat acatctgcaa cgtgaatcac aagccatcca atacaaaggt ggacaagaag      720

gtggagccca agtcttgtga taagacccac acatgccctc cctgtcctgc accagagctg      780

ctgggcggcc catccgtgtt cctgtttcca cccaagccta aggacaccct gatgatcagc      840

cggaccccag aggtgacatg cgtggtggtg gacgtgtccc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggatgg cgtggaggtg cacaatgcca agaccaagcc tagggaggag      960

cagtataact ctacctacag agtggtgagc gtgctgacag tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgtct aataaggccc tgcccgcccc tatcgagaag     1080

accatcagca aggcaaaggg acagcctcgg gagccacagg tgtatacact gcctccatct     1140

cgcgacgagc tgaccaagaa ccaggtgagc ctgacatgtc tggtgaaggg cttctaccct     1200

agcgatatcg ccgtggagtg ggagtccaat ggccagccag agaacaatta taagaccaca     1260

ccccctgtgc tggactctga tggcagcttc tttctgtact ccaagctgac cgtggataag     1320

tctcgctggc agcagggcaa cgtgttcagc tgtagcgtga tgcacgaagc cctgcacaac     1380

cactacaccc agaaaagcct gtcactgagc cccggaaaa                            1419


<210>  97
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4028 Lambda Light Chain

<400>  97

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Gln Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Val Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu 
        35                  40                  45              


Pro Glu Lys Tyr Ala Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro 
    50                  55                  60                  


Val Leu Ile Ile Tyr Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Met Ala Thr Leu Thr Ile Ser 
                85                  90                  95      


Gly Ala Gln Val Asp Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asn 
            100                 105                 110         


Ser Gly Gly Thr Phe Phe Val Phe Gly Thr Gly Thr Lys Val Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  98
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4028 Lambda Light Chain

<400>  98
atggcttgga cccctctgtt tctgtttctg ctgacctgtt gccccggagg aagtaattcc       60

cagagctacg aactgactca gcctcccagc gtgtccgtgt cccccggcca gactgccaga      120

atcacttgca gcggcgatgc cctgccagag aagtacgcct attggtacca gcagaagtct      180

ggccaggccc ccgtgctgat catctatgag gacagcaaga ggccctccgg catccctgag      240

aggttcagcg gctccagatc tggcaccatg gccaccctga caatcagcgg agcacaggtg      300

gacgatgagg cagattacta ttgctactcc actaactcag gcgggacatt tttcgtgttt      360

gggacaggga ctaaggtcac cgtgctggga cagcctaagg cagcaccatc cgtgacactg      420

tttccccctt cctctgagga gctgcaggcc aacaaggcca ccctggtgtg cctgatcagc      480

gacttctacc caggagcagt gaccgtggca tggaaggcag atagctcccc agtgaaggca      540

ggagtggaga caacaacccc ttctaagcag agcaacaata agtacgccgc ctctagctat      600

ctgtctctga cccccgagca gtggaagagc cacaagagct attcctgcca ggtcacccat      660

gaaggctcaa ccgtggagaa aacagtcgcc cctaccgaat gctca                      705


<210>  99
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2557 Heavy Chain

<400>  99

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Glu Val Lys Gln 
            20                  25                  30          


Pro Gly Gln Ser Leu Lys Ile Ser Cys Lys Ser Ser Gly Tyr Asn Phe 
        35                  40                  45              


Leu Asp Ser Trp Ile Gly Trp Val Arg Gln Ile Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ile Ile Tyr Pro Asp Asp Ser Asp Ala His Tyr Ser 
65                  70                  75                  80  


Pro Ser Phe Glu Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Thr Thr Leu Gln Ala Ser Asp Thr Gly Lys 
            100                 105                 110         


Tyr Phe Cys Thr Arg Leu Tyr Leu Phe Glu Gly Ala Gln Ser Ser Asn 
        115                 120                 125             


Ala Phe Asp Leu Trp Gly Gln Gly Thr Met Ile Leu Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  100
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2557 Heavy Chain

<400>  100
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctgaa       60

gtgcagctgg tggaatccgg gggcgaggtc aaacagcctg ggcagagcct gaagatcagt      120

tgtaaaagta gtgggtataa tttcctggac agctggatcg gatgggtgag gcagatccca      180

ggcaagggcc tggagtggat cggcatcatc taccccgacg attccgacgc ccactatagc      240

ccttccttcg agggccaggt gaccatgtct gtggataagt ctatcagcac agcctacctg      300

cagtggacca cactgcaggc ctccgatacc ggcaagtact tctgcacaag actgtatctg      360

tttgagggcg ctcagtcaag caacgcattc gatctgtggg ggcagggaac tatgattctg      420

gtgtcaagcg ccagcacaaa gggcccatcc gtgtttccac tggcaccctc ctctaagagc      480

acctccggcg gcacagccgc cctgggctgt ctggtgaagg attacttccc agagccagtg      540

accgtgagct ggaactccgg cgccctgacc tccggagtgc acacatttcc agccgtgctg      600

cagagctccg gcctgtatag cctgtctagc gtggtgaccg tgccctcctc tagcctgggc      660

acccagacat acatctgcaa cgtgaatcac aagccatcca atacaaaggt ggacaagaag      720

gtggagccca agtcttgtga taagacccac acatgccctc cctgtcctgc accagagctg      780

ctgggcggcc catccgtgtt cctgtttcca cccaagccta aggacaccct gatgatcagc      840

cggaccccag aggtgacatg cgtggtggtg gacgtgtccc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggatgg cgtggaggtg cacaatgcca agaccaagcc tagggaggag      960

cagtataact ctacctacag agtggtgagc gtgctgacag tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgtct aataaggccc tgcccgcccc tatcgagaag     1080

accatcagca aggcaaaggg acagcctcgg gagccacagg tgtatacact gcctccatct     1140

cgcgacgagc tgaccaagaa ccaggtgagc ctgacatgtc tggtgaaggg cttctaccct     1200

agcgatatcg ccgtggagtg ggagtccaat ggccagccag agaacaatta taagaccaca     1260

ccccctgtgc tggactctga tggcagcttc tttctgtact ccaagctgac cgtggataag     1320

tctcgctggc agcagggcaa cgtgttcagc tgtagcgtga tgcacgaagc cctgcacaac     1380

cactacaccc agaaaagcct gtcactgagc cccggaaaa                            1419


<210>  101
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2557 Lambda Light Chain

<400>  101

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Gln Ser Tyr Leu Leu Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Val Ser Pro Gly Gln Thr Ala Ser Ile Ser Cys Ser Gly Asp Lys Leu 
        35                  40                  45              


Asp Asp Lys Tyr Val Ser Trp Tyr Tyr Gln Arg Pro Gly Gln Ser Pro 
    50                  55                  60                  


Val Leu Leu Met Tyr Gln Asp Phe Lys Arg Pro Ser Gly Ile Pro Glu 
65                  70                  75                  80  


Arg Leu Ser Gly Ser Lys Ser Gly Lys Thr Ala Thr Leu Thr Ile Ser 
                85                  90                  95      


Gly Thr Gln Ser Leu Asp Glu Gly Asp Tyr Tyr Cys Gln Ala Trp Asp 
            100                 105                 110         


Ala Ser Thr Gly Val Ser Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
        115                 120                 125             


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
145                 150                 155                 160 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
                165                 170                 175     


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
            180                 185                 190         


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
        195                 200                 205             


His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
    210                 215                 220                 


Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230             


<210>  102
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2557 Lambda Light Chain

<400>  102
atggcttgga cccctctgtt tctgtttctg ctgacctgtt gccccggagg aagtaattcc       60

cagagctacc tgctgaccca gcctccttcc gtgagcgtga gccctggaca gaccgcatca      120

atttcttgtt ccggcgataa actggatgac aagtacgtgt cttggtacta tcagaggccc      180

ggacagagcc ctgtgctgct gatgtatcag gatttcaaga ggccatccgg catccccgag      240

agactgagcg gctccaagtc tggcaagacc gccacactga ccatcagcgg cacacagtcc      300

ctggacgagg gcgattacta ttgccaggct tgggatgctt caacaggcgt ctctggggga      360

ggaacaaaac tgaccgtgct gggacagcct aaggcagcac catccgtgac actgtttccc      420

ccttcctctg aggagctgca ggccaacaag gccaccctgg tgtgcctgat cagcgacttc      480

tacccaggag cagtgaccgt ggcatggaag gcagatagct ccccagtgaa ggcaggagtg      540

gagacaacaa ccccttctaa gcagagcaac aataagtacg ccgcctctag ctatctgtct      600

ctgacccccg agcagtggaa gagccacaag agctattcct gccaggtcac ccatgaaggc      660

tcaaccgtgg agaaaacagt cgcccctacc gaatgctca                             699


<210>  103
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F425-B4e8 Heavy Chain

<400>  103

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Phe Gly Phe Asn Phe 
        35                  40                  45              


Ser Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Tyr Leu Ser Ala Ile Ser Ser Asp Gly Glu Thr Thr Tyr His Ala 
65                  70                  75                  80  


Asn Ser Val Lys Gly Arg Phe Thr Ser Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Gly Ser Leu Arg Thr Glu Asp Val Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Arg Tyr Tyr Glu Thr Ser Gly Ser Asn Ala 
        115                 120                 125             


Phe Asp Val Trp Gly Gln Gly Thr Met Val Val Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  104
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F425-B4e8 Heavy Chain

<400>  104
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctcag       60

gtgcagctgg tgcagagcgg gggcggcctg gtgcagcctg gagggtcact gagactgtcc      120

tgtgccgcat tcgggttcaa tttcagctcc tacgtgatgc actgggtgag gcaggcacca      180

ggacagggcc tggagtacct gtctgccatc tctagcgacg gcgagacaac atatcacgcc      240

aactccgtga agggccggtt cacctcctct cgcgataaca gcaagaatac actgtttctg      300

cagatgggct ccctgaggac cgaggacgtg gccgtgtact attgcgccag ggatagatac      360

tatgagacaa gcggaagcaa cgcctttgac gtgtgggggc agggaacaat ggtggtggtc      420

tcctcagcca gcacaaaggg cccatccgtg tttccactgg caccctcctc taagagcacc      480

tccggcggca cagccgccct gggctgtctg gtgaaggatt acttcccaga gccagtgacc      540

gtgagctgga actccggcgc cctgacctcc ggagtgcaca catttccagc cgtgctgcag      600

agctccggcc tgtatagcct gtctagcgtg gtgaccgtgc cctcctctag cctgggcacc      660

cagacataca tctgcaacgt gaatcacaag ccatccaata caaaggtgga caagaaggtg      720

gagcccaagt cttgtgataa gacccacaca tgccctccct gtcctgcacc agagctgctg      780

ggcggcccat ccgtgttcct gtttccaccc aagcctaagg acaccctgat gatcagccgg      840

accccagagg tgacatgcgt ggtggtggac gtgtcccacg aggaccccga ggtgaagttc      900

aactggtacg tggatggcgt ggaggtgcac aatgccaaga ccaagcctag ggaggagcag      960

tataactcta cctacagagt ggtgagcgtg ctgacagtgc tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtgtctaat aaggccctgc ccgcccctat cgagaagacc     1080

atcagcaagg caaagggaca gcctcgggag ccacaggtgt atacactgcc tccatctcgc     1140

gacgagctga ccaagaacca ggtgagcctg acatgtctgg tgaagggctt ctaccctagc     1200

gatatcgccg tggagtggga gtccaatggc cagccagaga acaattataa gaccacaccc     1260

cctgtgctgg actctgatgg cagcttcttt ctgtactcca agctgaccgt ggataagtct     1320

cgctggcagc agggcaacgt gttcagctgt agcgtgatgc acgaagccct gcacaaccac     1380

tacacccaga aaagcctgtc actgagcccc ggaaaa                               1416


<210>  105
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F425 Kappa Light Chain

<400>  105

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asn Ser Val Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Thr Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Gly Gly Ser Gly Thr His Phe Ser Phe Thr Ile Thr 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Phe Cys Gln Gln Tyr Asp 
            100                 105                 110         


Asn Leu Gly Asp Leu Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  106
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F425 Kappa Light Chain

<400>  106
atggtgctgc agacccaggt gttcatttca ctgctgctgt ggatttcagg agcctacgga       60

aactctgtgc tgacccagtc tccatcttct ctgagcgcat ccgtcggcga ccgcgtgacc      120

atcacttgcc aggcttccca ggacatttct aactacctga attggtatca gcacaagccc      180

ggcaaggccc ctaagctgct gatctacacc gccagcaacc tggagacagg agtgcccagc      240

aggttcagcg gcggcggcag cggcacccac ttcagcttta ccatcacatc cctgcagcca      300

gaggacgcag caacatattt ttgccagcag tacgataatc tgggggacct gtcattcggc      360

ggcgggacca aagtggaaat caagcggacc gtggcagcac cttccgtgtt catctttccc      420

ccttctgacg agcagctgaa gtctggcaca gccagcgtgg tgtgcctgct gaacaacttc      480

taccccaggg aggccaaggt gcagtggaag gtggataacg ccctgcagag cggcaattcc      540

caggagtctg tgaccgagca ggacagcaag gattccacat attctctgag ctccaccctg      600

acactgagca aggccgacta cgagaagcac aaggtgtatg cctgcgaggt cacccatcag      660

gggctgtcaa gtccagtcac aaagtccttc aataggggcg aatgc                      705


<210>  107
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17B Heavy Chain

<400>  107

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe 
        35                  40                  45              


Ile Arg Tyr Ser Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Arg Ile Ile Thr Ile Leu Asp Val Ala His Tyr Ala 
65                  70                  75                  80  


Pro His Leu Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Val Tyr Leu Glu Leu Arg Asn Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Gly Val Tyr Glu Gly Glu Ala Asp Glu Gly Glu Tyr 
        115                 120                 125             


Asp Asn Asn Gly Phe Leu Lys His Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  108
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17B Heavy Chain

<400>  108
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctgaa       60

gtgcagctgg tggaaagcgg agccgaagtc aaaaaacctg ggtcaagcgt caaagtcagt      120

tgtaaggcaa gcggggatac attcatccgg tactctttca cctgggtgcg ccaggcacca      180

ggacagggcc tggagtggat gggcaggatc atcacaatcc tggacgtggc acactacgcc      240

cctcacctgc agggaagggt gaccatcaca gccgataaga gcacctccac agtgtatctg      300

gagctgagga acctgagaag cgacgatacc gccgtgtact tttgcgcagg cgtgtatgag      360

ggagaggcag acgagggcga gtacgacaac aacggatttc tgaagcattg gggacagggg      420

actctggtga cagtgagcag cgccagcaca aagggcccat ccgtgtttcc actggcaccc      480

tcctctaaga gcacctccgg cggcacagcc gccctgggct gtctggtgaa ggattacttc      540

ccagagccag tgaccgtgag ctggaactcc ggcgccctga cctccggagt gcacacattt      600

ccagccgtgc tgcagagctc cggcctgtat agcctgtcta gcgtggtgac cgtgccctcc      660

tctagcctgg gcacccagac atacatctgc aacgtgaatc acaagccatc caatacaaag      720

gtggacaaga aggtggagcc caagtcttgt gataagaccc acacatgccc tccctgtcct      780

gcaccagagc tgctgggcgg cccatccgtg ttcctgtttc cacccaagcc taaggacacc      840

ctgatgatca gccggacccc agaggtgaca tgcgtggtgg tggacgtgtc ccacgaggac      900

cccgaggtga agttcaactg gtacgtggat ggcgtggagg tgcacaatgc caagaccaag      960

cctagggagg agcagtataa ctctacctac agagtggtga gcgtgctgac agtgctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtgt ctaataaggc cctgcccgcc     1080

cctatcgaga agaccatcag caaggcaaag ggacagcctc gggagccaca ggtgtataca     1140

ctgcctccat ctcgcgacga gctgaccaag aaccaggtga gcctgacatg tctggtgaag     1200

ggcttctacc ctagcgatat cgccgtggag tgggagtcca atggccagcc agagaacaat     1260

tataagacca caccccctgt gctggactct gatggcagct tctttctgta ctccaagctg     1320

accgtggata agtctcgctg gcagcagggc aacgtgttca gctgtagcgt gatgcacgaa     1380

gccctgcaca accactacac ccagaaaagc ctgtcactga gccccggaaa a              1431


<210>  109
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17B Kappa Light Chain

<400>  109

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Ser Ser Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn 
            100                 105                 110         


Asn Trp Pro Pro Arg Tyr Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  110
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17B Kappa Light Chain

<400>  110
atggtgctgc agacccaggt gttcatttca ctgctgctgt ggatttcagg agcctacgga       60

gatattgtga tgacccagag cccagccacc ctgtccgtga gccccggcga gagagccacc      120

ctgtcctgta gagcctccga gagcgtgagc tccgacctgg catggtacca gcagaagcca      180

ggacaggccc ctaggctgct gatctatgga gcatccacca gggccacagg agtgccagca      240

agattctccg gctctggcag cggagcagag tttaccctga caatctctag cctgcagtct      300

gaggatttcg ccgtgtacta ttgccagcag tacaataact ggcctcctcg ctacaccttc      360

gggcagggca cacggctgga aatcaaaaga accgtggcag caccttccgt gttcatcttt      420

cccccttctg acgagcagct gaagtctggc acagccagcg tggtgtgcct gctgaacaac      480

ttctacccca gggaggccaa ggtgcagtgg aaggtggata acgccctgca gagcggcaat      540

tcccaggagt ctgtgaccga gcaggacagc aaggattcca catattctct gagctccacc      600

ctgacactga gcaaggccga ctacgagaag cacaaggtgt atgcctgcga ggtcacccat      660

caggggctgt caagtccagt cacaaagtcc ttcaataggg gcgaatgc                   708


<210>  111
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F105 Heavy Chain

<400>  111

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser His Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Gln Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Ser Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Glu Thr Ala Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Thr Ser Met Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Val Pro Ala Val Phe Tyr Gly Asp Tyr Arg 
        115                 120                 125             


Leu Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  112
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F105 Heavy Chain

<400>  112
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctcag       60

gtgcagctgc aggaaagcgg acccggcctg gtgaagccct ctgaaactct gtcactgact      120

tgtaccgtct ctgggggaag catcagctcc cactactgga gctggatcag gcagtcccca      180

ggcaagggcc tgcagtggat cggctacatc tactattctg gcagcaccaa ctattccccc      240

tctctgaagt ctagagtgac catcagcgtg gagacagcca agaatcagtt ctccctgaag      300

ctgacctcta tgacagccgc cgacacagcc gtgtactatt gcgccagggg ccccgtgcct      360

gccgtgtttt acggagatta tcggctggac ccttgggggc agggaacact ggtgactgtg      420

agtagcgcca gcacaaaggg cccatccgtg tttccactgg caccctcctc taagagcacc      480

tccggcggca cagccgccct gggctgtctg gtgaaggatt acttcccaga gccagtgacc      540

gtgagctgga actccggcgc cctgacctcc ggagtgcaca catttccagc cgtgctgcag      600

agctccggcc tgtatagcct gtctagcgtg gtgaccgtgc cctcctctag cctgggcacc      660

cagacataca tctgcaacgt gaatcacaag ccatccaata caaaggtgga caagaaggtg      720

gagcccaagt cttgtgataa gacccacaca tgccctccct gtcctgcacc agagctgctg      780

ggcggcccat ccgtgttcct gtttccaccc aagcctaagg acaccctgat gatcagccgg      840

accccagagg tgacatgcgt ggtggtggac gtgtcccacg aggaccccga ggtgaagttc      900

aactggtacg tggatggcgt ggaggtgcac aatgccaaga ccaagcctag ggaggagcag      960

tataactcta cctacagagt ggtgagcgtg ctgacagtgc tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtgtctaat aaggccctgc ccgcccctat cgagaagacc     1080

atcagcaagg caaagggaca gcctcgggag ccacaggtgt atacactgcc tccatctcgc     1140

gacgagctga ccaagaacca ggtgagcctg acatgtctgg tgaagggctt ctaccctagc     1200

gatatcgccg tggagtggga gtccaatggc cagccagaga acaattataa gaccacaccc     1260

cctgtgctgg actctgatgg cagcttcttt ctgtactcca agctgaccgt ggataagtct     1320

cgctggcagc agggcaacgt gttcagctgt agcgtgatgc acgaagccct gcacaaccac     1380

tacacccaga aaagcctgtc actgagcccc ggaaaa                               1416


<210>  113
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F105 Kappa Light Chain

<400>  113

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Ala Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Arg Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asp Asn Ser Val Cys Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  114
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F105 Kappa Light Chain

<400>  114
atggtgctgc agacccaggt gttcatttca ctgctgctgt ggatttcagg agcctacgga       60

gaaatcgtcc tgacccagtc ccccggaacc ctgagtctga gcgccggaga gcgagccacc      120

ctgagttgta gagcatcaca gagtgtcagc tcccggtacc tggcctggta tcagcagaag      180

ccaggacagg cccctcgcct gctgatctac ggagcctcta gcagggccac cggcatccca      240

gacagattct ccggctctgg cagcggcaca gacttcaccc tgacaatctc cagggtggag      300

cccgaggact tcgccgtgta ctattgccag cagtatgaca atagcgtctg taccttcggg      360

cagggcacca aactggaaat caagaggacc gtggcagcac cttccgtgtt catctttccc      420

ccttctgacg agcagctgaa gtctggcaca gccagcgtgg tgtgcctgct gaacaacttc      480

taccccaggg aggccaaggt gcagtggaag gtggataacg ccctgcagag cggcaattcc      540

caggagtctg tgaccgagca ggacagcaag gattccacat attctctgag ctccaccctg      600

acactgagca aggccgacta cgagaagcac aaggtgtatg cctgcgaggt cacccatcag      660

gggctgtcaa gtccagtcac aaagtccttc aataggggcg aatgc                      705


<210>  115
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  b12 Heavy Chain

<400>  115

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Gln Ala Ser Gly Tyr Arg Phe 
        35                  40                  45              


Ser Asn Phe Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Phe 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Pro Tyr Asn Gly Asn Lys Glu Phe Ser 
65                  70                  75                  80  


Ala Lys Phe Gln Asp Arg Val Thr Phe Thr Ala Asp Thr Ser Ala Asn 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Val Gly Pro Tyr Ser Trp Asp Asp Ser Pro Gln 
        115                 120                 125             


Asp Asn Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Ile Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  116
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  b12 Heavy Chain

<400>  116
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctcag       60

gtgcagctgg tccagtcagg agcagaagtg aagaaacccg gagcatcagt gaaagtcagt      120

tgtcaggcaa gcggatacag atttagcaac ttcgtgatcc actgggtgcg gcaggcacca      180

ggacagaggt tcgagtggat gggctggatc aatccttaca acggcaataa ggagttctcc      240

gccaagtttc aggacagggt gaccttcaca gccgatacct ctgccaacac agcctacatg      300

gagctgagga gcctgagatc cgccgacacc gccgtgtact attgcgcccg ggtgggacca      360

tattcttggg acgatagccc tcaggataac tattacatgg acgtgtgggg gaagggaaca      420

acagtcatcg tgtcatcagc cagcacaaag ggcccatccg tgtttccact ggcaccctcc      480

tctaagagca cctccggcgg cacagccgcc ctgggctgtc tggtgaagga ttacttccca      540

gagccagtga ccgtgagctg gaactccggc gccctgacct ccggagtgca cacatttcca      600

gccgtgctgc agagctccgg cctgtatagc ctgtctagcg tggtgaccgt gccctcctct      660

agcctgggca cccagacata catctgcaac gtgaatcaca agccatccaa tacaaaggtg      720

gacaagaagg tggagcccaa gtcttgtgat aagacccaca catgccctcc ctgtcctgca      780

ccagagctgc tgggcggccc atccgtgttc ctgtttccac ccaagcctaa ggacaccctg      840

atgatcagcc ggaccccaga ggtgacatgc gtggtggtgg acgtgtccca cgaggacccc      900

gaggtgaagt tcaactggta cgtggatggc gtggaggtgc acaatgccaa gaccaagcct      960

agggaggagc agtataactc tacctacaga gtggtgagcg tgctgacagt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgtcta ataaggccct gcccgcccct     1080

atcgagaaga ccatcagcaa ggcaaaggga cagcctcggg agccacaggt gtatacactg     1140

cctccatctc gcgacgagct gaccaagaac caggtgagcc tgacatgtct ggtgaagggc     1200

ttctacccta gcgatatcgc cgtggagtgg gagtccaatg gccagccaga gaacaattat     1260

aagaccacac cccctgtgct ggactctgat ggcagcttct ttctgtactc caagctgacc     1320

gtggataagt ctcgctggca gcagggcaac gtgttcagct gtagcgtgat gcacgaagcc     1380

ctgcacaacc actacaccca gaaaagcctg tcactgagcc ccggaaaa                  1428


<210>  117
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  b12 Kappa Light Chain

<400>  117

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Phe Ser Cys Arg Ser Ser His Ser 
        35                  40                  45              


Ile Arg Ser Arg Arg Val Ala Trp Tyr Gln His Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Val Ile His Gly Val Ser Asn Arg Ala Ser Gly Ile Ser 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Thr Arg Val Glu Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Val Tyr 
            100                 105                 110         


Gly Ala Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Arg Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  118
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  b12 Kappa Light Chain

<400>  118
atggtgctgc agacccaggt gttcatttca ctgctgctgt ggatttcagg agcctacgga       60

gagattgtgc tgacccagag tcctggaacc ctgtccctga gtcctggaga acgggccacc      120

ttttcatgcc gatcatccca tagtatcagg tctaggagag tggcatggta ccagcacaag      180

ccaggacagg cccctcggct ggtcatccac ggcgtgagca acagggcaag cggaatctcc      240

gaccgcttca gcggctccgg ctctggcaca gacttcaccc tgacaatcac cagggtggag      300

cccgaggact tcgccctgta ctattgccag gtctacgggg catcctccta tacattcgga      360

cagggcacaa aactggaacg gaaaagaacc gtggcagcac cttccgtgtt catctttccc      420

ccttctgacg agcagctgaa gtctggcaca gccagcgtgg tgtgcctgct gaacaacttc      480

taccccaggg aggccaaggt gcagtggaag gtggataacg ccctgcagag cggcaattcc      540

caggagtctg tgaccgagca ggacagcaag gattccacat attctctgag ctccaccctg      600

acactgagca aggccgacta cgagaagcac aaggtgtatg cctgcgaggt cacccatcag      660

gggctgtcaa gtccagtcac aaagtccttc aataggggcg aatgc                      705


<210>  119
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  b6 Heavy Chain

<400>  119

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Asn Ser Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Ala Trp Met Ala Trp Val Arg Gln Ala Pro Gly Arg Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Leu Ile Lys Ser Lys Ala Asp Gly Glu Thr Thr Asp 
65                  70                  75                  80  


Tyr Ala Thr Pro Val Lys Gly Arg Phe Ser Ile Ser Arg Asn Asn Leu 
                85                  90                  95      


Lys Asp Thr Val Tyr Leu Gln Met Asp Ser Leu Arg Ala Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Gln Lys Pro Arg Tyr Phe Asp Leu Leu 
        115                 120                 125             


Ser Gly Gln Tyr Arg Arg Val Ala Gly Ala Phe Asp Val Trp Gly His 
    130                 135                 140                 


Gly Thr Thr Val Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
145                 150                 155                 160 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
                165                 170                 175     


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
            180                 185                 190         


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
        195                 200                 205             


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
    210                 215                 220                 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
225                 230                 235                 240 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  120
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  b6 Heavy Chain

<400>  120
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctaac       60

tcacagctgg aggagagcgg cggcggcctg gtcaaacctg gcgggtccct gcgactgtct      120

tgcgtggggt ctggctttac tttcagctcc gcctggatgg catgggtgag gcaggcacca      180

ggaagaggcc tggagtgggt gggcctgatc aagagcaagg ccgacggcga gacaacagat      240

tacgccaccc ctgtgaaggg ccggttctct atcagccgca acaatctgaa ggacacagtg      300

tatctgcaga tggattccct gagggccgac gataccgccg tgtactattg cgccacacag      360

aagccccggt actttgacct gctgtctggc cagtatcgga gagtcgcagg ggcttttgat      420

gtctgggggc acggcacaac agtcacagtg tcaccagcca gcacaaaggg cccatccgtg      480

tttccactgg caccctcctc taagagcacc tccggcggca cagccgccct gggctgtctg      540

gtgaaggatt acttcccaga gccagtgacc gtgagctgga actccggcgc cctgacctcc      600

ggagtgcaca catttccagc cgtgctgcag agctccggcc tgtatagcct gtctagcgtg      660

gtgaccgtgc cctcctctag cctgggcacc cagacataca tctgcaacgt gaatcacaag      720

ccatccaata caaaggtgga caagaaggtg gagcccaagt cttgtgataa gacccacaca      780

tgccctccct gtcctgcacc agagctgctg ggcggcccat ccgtgttcct gtttccaccc      840

aagcctaagg acaccctgat gatcagccgg accccagagg tgacatgcgt ggtggtggac      900

gtgtcccacg aggaccccga ggtgaagttc aactggtacg tggatggcgt ggaggtgcac      960

aatgccaaga ccaagcctag ggaggagcag tataactcta cctacagagt ggtgagcgtg     1020

ctgacagtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtctaat     1080

aaggccctgc ccgcccctat cgagaagacc atcagcaagg caaagggaca gcctcgggag     1140

ccacaggtgt atacactgcc tccatctcgc gacgagctga ccaagaacca ggtgagcctg     1200

acatgtctgg tgaagggctt ctaccctagc gatatcgccg tggagtggga gtccaatggc     1260

cagccagaga acaattataa gaccacaccc cctgtgctgg actctgatgg cagcttcttt     1320

ctgtactcca agctgaccgt ggataagtct cgctggcagc agggcaacgt gttcagctgt     1380

agcgtgatgc acgaagccct gcacaaccac tacacccaga aaagcctgtc actgagcccc     1440

ggaaaa                                                                1446


<210>  121
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  b6 Kappa Light Chain

<400>  121

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Gly Gln Ser 
        35                  40                  45              


Ile Ser Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Thr Ser Pro Tyr Thr Phe Gly Gln Gly Thr Gln Leu Asp Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  122
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  b6 Kappa Light Chain

<400>  122
atggtgctgc agacccaggt gttcatttca ctgctgctgt ggatttcagg agcctacgga       60

gaaatcgtcc tgacccagtc ccctggcacc ctgtccctgt cccctggaga aagagccacc      120

ctgagttgta gagccgggca gagcattagc tccaactacc tggcctggta tcagcagaag      180

ccaggacagg cccctcggct gctgatctac ggagcatcca atagggcaac cggcatccca      240

gacagattct ctggcagcgg ctccggaacc gacttcaccc tgtctatcag ccgcctggag      300

ccagaggact tcgccgtgta ctattgccag cagtatggca cttcacctta cacttttgga      360

cagggaactc agctggacat caagcgaacc gtggcagcac cttccgtgtt catctttccc      420

ccttctgacg agcagctgaa gtctggcaca gccagcgtgg tgtgcctgct gaacaacttc      480

taccccaggg aggccaaggt gcagtggaag gtggataacg ccctgcagag cggcaattcc      540

caggagtctg tgaccgagca ggacagcaag gattccacat attctctgag ctccaccctg      600

acactgagca aggccgacta cgagaagcac aaggtgtatg cctgcgaggt cacccatcag      660

gggctgtcaa gtccagtcac aaagtccttc aataggggcg aatgc                      705


<210>  123
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11A Heavy Chain

<400>  123

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Asn Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Leu Ser Leu Thr Cys Lys Ala Ser Gly Phe Asp Phe 
        35                  40                  45              


Ser Asp Asn Tyr Tyr Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Cys Ile Phe Thr Gln Asn Val Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr 
                85                  90                  95      


Thr Val Thr Leu Gln Met Thr Ser Leu Thr Val Ala Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Phe Ser Asp Thr Gly Pro Asp Tyr Gly Leu Gly 
        115                 120                 125             


Asn Leu Trp Gly Pro Gly Ser Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  124
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11A Heavy Chain

<400>  124
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctaat       60

agccagctgg tggagagcgg cggcggcctg gtgaaacctg gaacctcact gtccctgacc      120

tgtaaggcaa gcggatttga cttctccgac aactactata tctgctgggt gcggcaggca      180

ccaggcaagg gcctggagtg gatcggctgt atcttcaccc agaacgtgag gacatactat      240

gccaattggg ccaagggcag gttcaccatc tctaagacaa gctccaccac agtgaccctg      300

cagatgacca gcctgacagt ggccgacacc gccacatact tctgcgcccg cttttctgat      360

acaggacctg actacggact gggaaatctg tggggacctg ggagcctggt gactgtctca      420

tcagccagca caaagggccc atccgtgttt ccactggcac cctcctctaa gagcacctcc      480

ggcggcacag ccgccctggg ctgtctggtg aaggattact tcccagagcc agtgaccgtg      540

agctggaact ccggcgccct gacctccgga gtgcacacat ttccagccgt gctgcagagc      600

tccggcctgt atagcctgtc tagcgtggtg accgtgccct cctctagcct gggcacccag      660

acatacatct gcaacgtgaa tcacaagcca tccaatacaa aggtggacaa gaaggtggag      720

cccaagtctt gtgataagac ccacacatgc cctccctgtc ctgcaccaga gctgctgggc      780

ggcccatccg tgttcctgtt tccacccaag cctaaggaca ccctgatgat cagccggacc      840

ccagaggtga catgcgtggt ggtggacgtg tcccacgagg accccgaggt gaagttcaac      900

tggtacgtgg atggcgtgga ggtgcacaat gccaagacca agcctaggga ggagcagtat      960

aactctacct acagagtggt gagcgtgctg acagtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gtctaataag gccctgcccg cccctatcga gaagaccatc     1080

agcaaggcaa agggacagcc tcgggagcca caggtgtata cactgcctcc atctcgcgac     1140

gagctgacca agaaccaggt gagcctgaca tgtctggtga agggcttcta ccctagcgat     1200

atcgccgtgg agtgggagtc caatggccag ccagagaaca attataagac cacaccccct     1260

gtgctggact ctgatggcag cttctttctg tactccaagc tgaccgtgga taagtctcgc     1320

tggcagcagg gcaacgtgtt cagctgtagc gtgatgcacg aagccctgca caaccactac     1380

acccagaaaa gcctgtcact gagccccgga aaa                                  1413


<210>  125
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11A Kappa Light Chain

<400>  125

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gly Met Thr Gln Thr Pro Ala Ser Gly Glu 
            20                  25                  30          


Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Arg 
        35                  40                  45              


Ile Gly Ser His Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Arg Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ala Thr Tyr 
            100                 105                 110         


Asp Pro Tyr Thr Gly Gly Ser Tyr Gly Ala Gly Phe Gly Gly Gly Thr 
        115                 120                 125             


Ala Val Val Val Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  126
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11A Kappa Light Chain

<400>  126
atggtgctgc agacccaggt gttcatttca ctgctgctgt ggatttcagg agcctacgga       60

gacatcggaa tgacccagac accagccagc ggggaagcag ccgtcggggg aacagtgaca      120

atcaagtgcc aggccagcca gagaatcggc agccacgtgt cctggtacca gcagaagccc      180

ggccagaggc ctaagctgct gatctatggc gcctccaacc tggagtctgg cgtgccatct      240

aggttcagcg gcagaggcag cggcacccag tttaccctga caatctccga cctggagtgc      300

gcagatgcag caacctacta ttgtcaggcc acatacgacc cctacactgg gggcagctat      360

ggagcaggat ttgggggagg aacagccgtc gtcgtgaaaa ggaccgtggc agcaccttcc      420

gtgttcatct ttcccccttc tgacgagcag ctgaagtctg gcacagccag cgtggtgtgc      480

ctgctgaaca acttctaccc cagggaggcc aaggtgcagt ggaaggtgga taacgccctg      540

cagagcggca attcccagga gtctgtgacc gagcaggaca gcaaggattc cacatattct      600

ctgagctcca ccctgacact gagcaaggcc gactacgaga agcacaaggt gtatgcctgc      660

gaggtcaccc atcaggggct gtcaagtcca gtcacaaagt ccttcaatag gggcgaatgc      720


<210>  127
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12N Heavy Chain

<400>  127

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Asn Ser Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Glu Gly Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe 
        35                  40                  45              


Ser Ser Gly Tyr Tyr Val Cys Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Asp Trp Val Ala Cys Ile Tyr Val Gly Ser Ser Gly Ile Thr Asp 
65                  70                  75                  80  


Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Ser 
                85                  90                  95      


Thr Thr Val Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Phe Cys Ala Arg Gly Gly Val Gly Asp Tyr Gly Val Ile Ser 
        115                 120                 125             


Asp Phe Arg Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  128
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12N Heavy Chain

<400>  128
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctaac       60

tcacagctgg tggaaagtgg aggcgacctg gtgaaacccg aaggcagtct gaccctgacc      120

tgtaccgcaa gtggattctc attcagctcc ggctactacg tgtgctgggt gcggcaggca      180

ccaggcaagg gcctggactg ggtggcctgt atctacgtgg gctctagcgg catcaccgat      240

tatgccacat gggccaaggg caggttcacc atcagcagaa catcctctac cacagtgacc      300

ctgcagatga cctccctgac agcagcagac accgcaacat acttttgcgc ccgcggcggc      360

gtgggcgatt atggggtcat ttctgatttt cggctgtggg ggcctgggac actggtcacc      420

gtctcatctg ccagcacaaa gggcccatcc gtgtttccac tggcaccctc ctctaagagc      480

acctccggcg gcacagccgc cctgggctgt ctggtgaagg attacttccc agagccagtg      540

accgtgagct ggaactccgg cgccctgacc tccggagtgc acacatttcc agccgtgctg      600

cagagctccg gcctgtatag cctgtctagc gtggtgaccg tgccctcctc tagcctgggc      660

acccagacat acatctgcaa cgtgaatcac aagccatcca atacaaaggt ggacaagaag      720

gtggagccca agtcttgtga taagacccac acatgccctc cctgtcctgc accagagctg      780

ctgggcggcc catccgtgtt cctgtttcca cccaagccta aggacaccct gatgatcagc      840

cggaccccag aggtgacatg cgtggtggtg gacgtgtccc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggatgg cgtggaggtg cacaatgcca agaccaagcc tagggaggag      960

cagtataact ctacctacag agtggtgagc gtgctgacag tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgtct aataaggccc tgcccgcccc tatcgagaag     1080

accatcagca aggcaaaggg acagcctcgg gagccacagg tgtatacact gcctccatct     1140

cgcgacgagc tgaccaagaa ccaggtgagc ctgacatgtc tggtgaaggg cttctaccct     1200

agcgatatcg ccgtggagtg ggagtccaat ggccagccag agaacaatta taagaccaca     1260

ccccctgtgc tggactctga tggcagcttc tttctgtact ccaagctgac cgtggataag     1320

tctcgctggc agcagggcaa cgtgttcagc tgtagcgtga tgcacgaagc cctgcacaac     1380

cactacaccc agaaaagcct gtcactgagc cccggaaaa                            1419


<210>  129
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12N Kappa Light Chain

<400>  129

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu 
            20                  25                  30          


Val Pro Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn 
        35                  40                  45              


Ile Tyr Ser His Asn Tyr Leu Ser Trp Tyr Gln Leu Lys Leu Gly Gln 
    50                  55                  60                  


Pro Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Phe 
            100                 105                 110         


Thr Tyr Gly Ser Ala Ser Thr Gly Thr Tyr Val Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys 
    


<210>  130
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12N Kappa Light Chain

<400>  130
atggtgctgc agacccaggt gttcatttca ctgctgctgt ggatttcagg agcctacgga       60

gacattgtga tgactcagac accagccagc gtggaagtgc cagtgggagg aacagtgacc      120

attaagtgcc aggccagcca gaacatttac tctcacaact atctgagctg gtaccagctg      180

aagctgggcc agccccctaa gctgctgatc tataaggcat ctaccctgga gagcggagtg      240

ccctccaggt tcaagggcag cggctccggc acagagttta ccctgacaat ctccgacctg      300

gagtgcgcag atgcagcaac ctactattgt cagttcacat acggctcagc atcaacagga      360

acctatgtgg cattcggcgg agggacagaa gtggtggtga agcggaccgt ggcagcacct      420

tccgtgttca tctttccccc ttctgacgag cagctgaagt ctggcacagc cagcgtggtg      480

tgcctgctga acaacttcta ccccagggag gccaaggtgc agtggaaggt ggataacgcc      540

ctgcagagcg gcaattccca ggagtctgtg accgagcagg acagcaagga ttccacatat      600

tctctgagct ccaccctgac actgagcaag gccgactacg agaagcacaa ggtgtatgcc      660

tgcgaggtca cccatcaggg gctgtcaagt ccagtcacaa agtccttcaa taggggcgaa      720

tgc                                                                    723


<210>  131
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39F Heavy Chain

<400>  131

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Phe Tyr Ile Gln Trp Leu Arg Gln Ala Pro Val Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Leu Val Asp Pro Glu Asp Gly Gln Thr Arg Tyr Pro 
65                  70                  75                  80  


Gln Arg Phe Gln Gly Arg Val Thr Met Thr Ala Asp Pro Ser Thr Asp 
                85                  90                  95      


Thr Ala Tyr Met Glu Val Ser Gly Leu Asp Phe Glu Asp Thr Ala Asp 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Ser Thr Leu Leu Gly Gly Pro Tyr Asp Asn Ser 
        115                 120                 125             


Gly His Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Lys Val Ile Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  132
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  39F Heavy Chain

<400>  132
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac tcacgctgaa       60

gtgcagctgg tccagtcagg ggcagaggtc aaaaaacccg gctccaccgt gaagattagt      120

tgtaaagcaa gcggctatac atttaccgat ttctacatcc agtggctgag gcaggcacca      180

gtgaagggcc tggagtggat gggcctggtg gaccccgagg atggacagac aaggtaccct      240

cagagattcc agggccgggt gaccatgaca gccgatccaa gcaccgacac agcctatatg      300

gaggtgtccg gcctggactt tgaggatacc gccgactact attgcgccac ctctacactg      360

ctgggcggcc catatgacaa tagcggacac gacgccttcg acatctgggg gcaggggact      420

aaagtgattg tgagtagcgc cagcacaaag ggcccatccg tgtttccact ggcaccctcc      480

tctaagagca cctccggcgg cacagccgcc ctgggctgtc tggtgaagga ttacttccca      540

gagccagtga ccgtgagctg gaactccggc gccctgacct ccggagtgca cacatttcca      600

gccgtgctgc agagctccgg cctgtatagc ctgtctagcg tggtgaccgt gccctcctct      660

agcctgggca cccagacata catctgcaac gtgaatcaca agccatccaa tacaaaggtg      720

gacaagaagg tggagcccaa gtcttgtgat aagacccaca catgccctcc ctgtcctgca      780

ccagagctgc tgggcggccc atccgtgttc ctgtttccac ccaagcctaa ggacaccctg      840

atgatcagcc ggaccccaga ggtgacatgc gtggtggtgg acgtgtccca cgaggacccc      900

gaggtgaagt tcaactggta cgtggatggc gtggaggtgc acaatgccaa gaccaagcct      960

agggaggagc agtataactc tacctacaga gtggtgagcg tgctgacagt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgtcta ataaggccct gcccgcccct     1080

atcgagaaga ccatcagcaa ggcaaaggga cagcctcggg agccacaggt gtatacactg     1140

cctccatctc gcgacgagct gaccaagaac caggtgagcc tgacatgtct ggtgaagggc     1200

ttctacccta gcgatatcgc cgtggagtgg gagtccaatg gccagccaga gaacaattat     1260

aagaccacac cccctgtgct ggactctgat ggcagcttct ttctgtactc caagctgacc     1320

gtggataagt ctcgctggca gcagggcaac gtgttcagct gtagcgtgat gcacgaagcc     1380

ctgcacaacc actacaccca gaaaagcctg tcactgagcc ccggaaaa                  1428


<210>  133
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39F Lambda Light Chain

<400>  133

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Gln Leu Pro Val Leu Thr Gln Pro Pro Ser Ala Ser 
            20                  25                  30          


Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Gly Ser 
        35                  40                  45              


Ser Phe Glu Arg Asn Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Met 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Arg Ser Asp Gln Arg Leu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Lys Ser Asp Thr Ser Ala Ser Leu Ala 
                85                  90                  95      


Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Thr Tyr Tyr Cys Ala Ala 
            100                 105                 110         


Trp Asp Asp Ser Leu Thr Leu Leu Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  134
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  39F Lambda Light Chain

<400>  134
atggcttgga cccctctgtt tctgtttctg ctgacctgtt gccccggagg aagtaattcc       60

cagctgcccg tcctgactca gcctcctagc gcaagcggca ctcctggaca gagggtgacc      120

attagttgta gcggaagcgg aagtagtttc gagaggaact acgtgtattg gtaccagcag      180

ctgcccggca tggcccctaa gctgctgatc tataggtccg accagagact gtctggcgtg      240

cccgatcggt ttagcggctc caagtctgac accagcgcct ccctggcaat ctctggcctg      300

cgcagcgagg atgaggccac atactattgc gctgcttggg atgactctct gacactgctg      360

ttcgggggag ggacaaaact gactgtgctg ggacagccta aggcagcacc atccgtgaca      420

ctgtttcccc cttcctctga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc      480

agcgacttct acccaggagc agtgaccgtg gcatggaagg cagatagctc cccagtgaag      540

gcaggagtgg agacaacaac cccttctaag cagagcaaca ataagtacgc cgcctctagc      600

tatctgtctc tgacccccga gcagtggaag agccacaaga gctattcctg ccaggtcacc      660

catgaaggct caaccgtgga gaaaacagtc gcccctaccg aatgctca                   708


<210>  135
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype A consensus Envelope DNA sequence construct

<400>  135
ggatccatgg actggacctg gattctgttc ctggtggccg ccgccaccag agtgcacagc       60

agagtgatgg gcatccagcg gaattgccag cacctgtgga gatggggcac catgatcctg      120

ggcatgatca tcatctgctc tgccgccgag aacctgtggg tgaccgtgta ctacggcgtg      180

cctgtgtgga aggacgccga gaccaccctg ttctgcgcca gcgacgccaa ggcctacgat      240

accgaagtgc acaatgtgtg ggccacccac gcctgcgtgc ctaccgatcc caacccccag      300

gagatcaacc tggagaacgt gaccgaggag ttcaacatgt ggaagaacaa catggtggag      360

cagatgcaca ccgacatcat cagcctgtgg gaccagagcc tgaagccttg cgtgaagctg      420

acccctctgt gcgtgaccct gaactgcagc aacgtgaacg tgaccaccaa catcatgaag      480

ggcgagatca agaactgcag cttcaacatg accaccgagc tgcgggacaa gaagcagaaa      540

gtgtacagcc tgttctacaa gctggacgtg gtgcagatca acaagagcaa cagcagcagc      600

cagtaccggc tgatcaactg caacaccagc gccatcaccc aggcctgccc caaagtgagc      660

ttcgagccca tccccatcca ctactgcgcc cctgccggct tcgccatcct gaagtgcaag      720

gacaaggagt ttaacggcac cggcccctgc aagaatgtga gcaccgtgca gtgcacccac      780

ggcatcaagc ccgtggtgtc cacccagctg ctgctgaacg gcagcctggc cgaggaggaa      840

gtgatgatcc ggagcgagaa catcaccaac aacgccaaga acatcatcgt gcagctgacc      900

aagcccgtga agatcaattg cacccggccc aacaacaaca cccggaagag catcagaatc      960

ggccctggcc aggccttcta cgccaccggc gacatcatcg gcgatatcag gcaggcccac     1020

tgcaatgtga gccggaccga gtggaacgag accctgcaga aagtggccaa gcagctgcgg     1080

aagtacttca acaacaagac catcatcttc accaacagca gcggcggcag actgagaatc     1140

accacccaca gcttcaattg tggcggcgag ttcttctact gcaatacctc cggcctgttc     1200

aacagcacct ggaacggcaa cggcaccaag aagaagaaca gcaccgagag caacgacacc     1260

atcaccctgc cctgccggat caagcagatc atcaatatgt ggcagagggt gggccaggcc     1320

atgtacgccc ctcccatcca gggcgtgatc agatgcgaga gcaacatcac cggcctgctg     1380

ctgaccagag atggcggcga caacaacagc aagaacgaga ccttcagacc tggcggcgga     1440

gacatgaggg acaactggcg gagcgagctg tacaagtaca aagtggtgaa gatcgagccc     1500

ctgggcgtgg cccccaccaa ggccaagaga agagtggtgg agcgggagaa gagagctgtg     1560

ggcatcggcg ccgtgttcct gggcttcctg ggagccgccg gaagcaccat gggagccgcc     1620

agcatcaccc tgaccgtgca ggccagacag ctgctgagcg gcattgtgca gcagcagagc     1680

aacctgctga gagccatcga ggcccagcag cacctgctga agctgacagt gtggggcatc     1740

aaacagctgc aggcccgcgt gctggccgtg gagagatacc tgaaggacca gcagctgctg     1800

ggcatctggg gctgcagcgg caagctgatc tgcaccacca acgtgccctg gaatagcagc     1860

tggagcaaca agagccagag cgagatctgg gacaacatga cctggctgca gtgggacaag     1920

gagatcagca actacaccga tatcatctac aacctgatcg aggagagcca gaaccagcag     1980

gagaagaacg agcaggatct gctggccctg gacaagtggg ccaacctgtg gaactggttc     2040

gacatcagca actggctgtg gtacatcaag atcttcatca tgattgtggg cggcctgatc     2100

ggcctgagaa tcgtgttcgc cgtgctgtct gtgtgactcg ag                        2142


<210>  136
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype A consensus Envelope protein sequence construct

<400>  136

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Met Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg 
            20                  25                  30          


Trp Gly Thr Met Ile Leu Gly Met Ile Ile Ile Cys Ser Ala Ala Glu 
        35                  40                  45              


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala 
    50                  55                  60                  


Glu Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
65                  70                  75                  80  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Ile Asn Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Ser Asn Val Asn Val Thr Thr Asn Ile Met Lys Gly Glu 
145                 150                 155                 160 


Ile Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys 
                165                 170                 175     


Gln Lys Val Tyr Ser Leu Phe Tyr Lys Leu Asp Val Val Gln Ile Asn 
            180                 185                 190         


Lys Ser Asn Ser Ser Ser Gln Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
        195                 200                 205             


Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile 
    210                 215                 220                 


His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys 
225                 230                 235                 240 


Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Glu Glu Val Met Ile Arg Ser Glu Asn Ile Thr Asn 
        275                 280                 285             


Asn Ala Lys Asn Ile Ile Val Gln Leu Thr Lys Pro Val Lys Ile Asn 
    290                 295                 300                 


Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro 
305                 310                 315                 320 


Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Val Ser Arg Thr Glu Trp Asn Glu Thr Leu Gln Lys 
            340                 345                 350         


Val Ala Lys Gln Leu Arg Lys Tyr Phe Asn Asn Lys Thr Ile Ile Phe 
        355                 360                 365             


Thr Asn Ser Ser Gly Gly Arg Leu Arg Ile Thr Thr His Ser Phe Asn 
    370                 375                 380                 


Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser 
385                 390                 395                 400 


Thr Trp Asn Gly Asn Gly Thr Lys Lys Lys Asn Ser Thr Glu Ser Asn 
                405                 410                 415     


Asp Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
            420                 425                 430         


Gln Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile 
        435                 440                 445             


Arg Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
    450                 455                 460                 


Asp Asn Asn Ser Lys Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
                485                 490                 495     


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu 
            500                 505                 510         


Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln 
    610                 615                 620                 


Ser Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile 
625                 630                 635                 640 


Ser Asn Tyr Thr Asp Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala 
            660                 665                 670         


Asn Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
        675                 680                 685             


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe 
    690                 695                 700                 


Ala Val Leu Ser Val 
705                 


<210>  137
<211>  2734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Envelope DNA sequence construct

<400>  137
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggccgccgc caccagagtg       60

cacagcagag tgaagggcat ccggaagaac taccagcacc tgtggagatg gggcaccatg      120

ctgctgggca tgctgatgat ctgttctgcc gccgagaagc tgtgggtgac cgtgtactac      180

ggcgtgcctg tgtggaagga ggccaccacc accctgttct gcgccagcga cgccaaggcc      240

tacgataccg aagtgcacaa tgtgtgggcc acccacgcct gcgtgcctac cgatcccaac      300

cctcaggaag tggtgctgga gaacgtgacc gagaacttca acatgtggaa gaacaacatg      360

gtggagcaga tgcacgagga catcatcagc ctgtgggacc agagcctgaa gccttgcgtg      420

aagctgaccc ctctgtgcgt gaccctgaac tgcaccgacc tgagcggcga gaagatggag      480

aagggcgaga tcaagaactg cagcttcaac atcaccacct ccatccggga caaagtgcag      540

aaggagtacg ccctgttcta caagctggac gtggtgccca tcgacaacga caacaccagc      600

taccggctga tcagctgcaa caccagcgtg atcacccagg cctgccccaa agtgagcttc      660

gagcccatcc ccatccacta ctgcgcccct gccggcttcg ccatcctgaa gtgcaacgac      720

aagaagttca acggcaccgg cccttgcacc aatgtgagca ccgtgcagtg cacccacggc      780

atcagacccg tggtgtccac ccagctgctg ctgaacggca gcctggccga ggaagaagtg      840

gtgatccgga gcgagaattt caccaacaac gccaagacca tcatcgtgca gctgaacgag      900

agcgtggaga tcaactgcac ccggcccaac aacaataccc ggaagagcat ccacatcggc      960

cctggccagg ccttctacac caccggcgag atcatcggcg atatcaggca ggcccactgc     1020

aatatcagcc gggccaagtg gaacaacacc ctgaagcaga tcgtgaagaa gctgcgggag     1080

cagttcggca acaagaccat cgtgttcaac cagagcagcg gcggcagacc tagaatcgtg     1140

atgcacagct tcaactgtgg cggcgagttc ttctactgca acacaaccca gctgttcaac     1200

agcacctgga acgtgaacgg gacctggaac aacaacaccg agggcaacga caccatcacc     1260

ctgccctgcc ggatcaagca gatcatcaat atgtggcagg aggtgggcaa ggccatgtac     1320

gcccctccca tcagaggcca gatccggtgc agcagcaata tcaccggcct gctgctgacc     1380

agagatggcg gcaacaataa caccaacgag accgagatct ttagacctgg cggcggagac     1440

atgagggaca actggcggag cgagctgtac aagtacaaag tggtgaagat cgagcccctg     1500

ggcgtggccc ccaccaaggc caagagaaga gtggtgcagc gggagaagag agctgtgggc     1560

atcggcgcca tgtttctggg ctttctggga gccgccggaa gcaccatggg agccgccagc     1620

atgaccctga ccgtgcaggc cagacagctg ctgagcggca tcgtgcagca gcagaacaac     1680

ctgctgagag ccatcgaggc ccagcagcac ctgctgcagc tgacagtgtg gggcatcaag     1740

cagctgcagg cccgcgtgct ggccgtggag agatacctga aggaccagca gctgctggga     1800

atctggggct gcagcggcaa gctgatctgc accaccaccg tgccctggaa cgccagctgg     1860

agcaacaaga gcctggacga gatctgggac aacatgacct ggatggagtg ggagcgggag     1920

atcgacaact acaccagcct gatctacacc ctgatcgagg agagccagaa ccagcaggag     1980

aagaacgagc aggagctgct ggagctggac aagtgggcca gcctgtggaa ctggttcgac     2040

atcaccaact ggctgtggta catcaagatc ttcatcatga ttgtgggcgg cctgatcggc     2100

ctgagaatcg tgttcgccgt gctgagcatc tacccctacg acgtgcccga ttacgcctga     2160

gaattcgtaa gtaagtgtca tatgggagag ctcgactaga ctggacagcc aatgacgggt     2220

aagagagtga catttctcac taacctaaga caggagggcc gtcaaagcta ctgcctaatc     2280

caatgacggg taatagtgac aagaaatgta tcactccaac ctaagacagg cgcagcctcc     2340

gagggatgtg tcttttgttt tttataatta aaaagggtga catgtccgga gccgtgctgc     2400

ccggatgatg tcttggcctc tgtttgctac cggtatcgat gttaacgtcg accccgggct     2460

cgaggtaagt aagtgtcata tgggagagct cgactagact ggacagccaa tgacgggtaa     2520

gagagtgaca tttctcacta acctaagaca ggagggccgt caaagctact gcctaatcca     2580

atgacgggta atagtgacaa gaaatgtatc actccaacct aagacaggcg cagcctccga     2640

gggatgtgtc ttttgttttt tataattaaa aagggtgaca tgtccggagc cgtgctgccc     2700

ggatgatgtc ttggcctctg tttgctgcgg ccgc                                 2734


<210>  138
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Envelope protein sequence construct

<400>  138

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg 
            20                  25                  30          


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu 
        35                  40                  45              


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
    50                  55                  60                  


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
65                  70                  75                  80  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Thr Asp Leu Ser Gly Glu Lys Met Glu Lys Gly Glu Ile 
145                 150                 155                 160 


Lys Asn Cys Ser Phe Asn Ile Thr Thr Ser Ile Arg Asp Lys Val Gln 
                165                 170                 175     


Lys Glu Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn 
            180                 185                 190         


Asp Asn Thr Ser Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys 
        275                 280                 285             


Thr Ile Ile Val Gln Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg 
    290                 295                 300                 


Pro Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Gln Ala 
305                 310                 315                 320 


Phe Tyr Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
                325                 330                 335     


Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Lys 
            340                 345                 350         


Lys Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser 
        355                 360                 365             


Ser Gly Gly Arg Pro Arg Ile Val Met His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Asn 
385                 390                 395                 400 


Val Asn Gly Thr Trp Asn Asn Asn Thr Glu Gly Asn Asp Thr Ile Thr 
                405                 410                 415     


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
            420                 425                 430         


Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Thr 
    450                 455                 460                 


Asn Glu Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn 
465                 470                 475                 480 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu 
                485                 490                 495     


Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys 
            500                 505                 510         


Arg Ala Val Gly Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala 
        515                 520                 525             


Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg 
    530                 535                 540                 


Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala 
545                 550                 555                 560 


Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys 
                565                 570                 575     


Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 
            580                 585                 590         


Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr 
        595                 600                 605             


Thr Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Asp Glu Ile 
    610                 615                 620                 


Trp Asp Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr 
625                 630                 635                 640 


Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 
                645                 650                 655     


Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 
            660                 665                 670         


Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile 
        675                 680                 685             


Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu 
    690                 695                 700                 


Ser Ile Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
705                 710                 715 


<210>  139
<211>  2140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype C consensus Envelope DNA sequence construct

<400>  139
ggatccgcca ccatggattg gacctggatt ctgttcctgg tggccgccgc cacaagagtg       60

cacagcagag tgcggggcat cctgagaaat tgccagcagt ggtggatctg gggcattctg      120

gggttctgga tgctgatgat ctgcaacgtg atgggcaacc tgtgggtgac cgtgtactac      180

ggcgtgcctg tgtggaagga ggccaagacc accctgttct gtgccagcga tgccaaggcc      240

tacgagaccg aggtgcacaa tgtgtgggcc acccacgcct gtgtgcccac cgatcccaac      300

cctcaggaga tggtgctgga gaacgtgacc gagaacttca acatgtggaa gaacgacatg      360

gtggaccaga tgcacgagga catcatcagc ctgtgggacc agagcctgaa gccttgcgtg      420

aagctgaccc ctctgtgcgt gaccctgaac tgccggaaca acgtgaacaa caacaacacc      480

atgaaggagg agatcaagaa ctgcagcttc aacatcacca ccgagctgcg ggacaagaag      540

cagaaggtgt acgccctgtt ctaccggctg gacatcgtgc ccctgaacga gaagaacaac      600

agcaacgact accggctgat caactgcaac accagcgcca tcacccaggc ctgtcccaag      660

gtgtccttcg accccatccc catccactat tgtgcccctg ccggctacgc catcctgaag      720

tgcaacaaca agaccttcaa cggcaccggc ccctgcaata atgtgagcac cgtgcagtgt      780

acccacggca tcaagcctgt ggtgtccacc cagctgctgc tgaatggcag cctggccgag      840

gaggagatta tcatccggag cgagaacctg accaacaacg ccaagaccat cattgtgcac      900

ctgaatgaga gcgtggagat cgtgtgtacc cggcccaaca acaatacccg gaagagcatc      960

agaatcggcc ctggccagac cttttacgcc accggcgaca tcatcggcga tatcaggcag     1020

gcccactgca atatcagcga ggagaagtgg aacaagaccc tgcagcgggt gtccgagaag     1080

ctgaaggagc acttccccaa taagaccatc aagttcgccc ctagcagcgg cggcagactg     1140

gagatcacca cccacagctt caactgcagg ggcgagttct tctactgcaa taccagcaag     1200

ctgttcaaca gcacctacat gcccaacagc accaacaata ccaacaccac catcaccctg     1260

ccctgccgga tcaagcagat catcaatatg tggcaggaag tgggcagagc catgtacgcc     1320

cctcccatcg agggcaacat cacctgcaag tccaacatca ccggcctgct gctgacaaga     1380

gatggcggca agaacgacac caatgacacc gagaccttca gacctggcgg cggagacatg     1440

agggacaact ggcggagcga gctgtacaag tacaaggtgg tggagatcaa gcctctgggc     1500

gtggccccta ccaaggccaa gaggagagtg gtggagaggg agaagagagc cgtgggcatc     1560

ggcgccgtgt ttctgggctt tctgggagcc gccggatcta caatgggagc cgccagcatc     1620

acactgaccg tgcaggccag acagctgctg agcggcatcg tgcagcagca gagcaatctg     1680

ctgagagcca tcgaggccca gcagcacatg ctgcagctga cagtgtgggg catcaagcag     1740

ctgcagacca gagtgctggc catcgagcgc tacctgaagg atcagcagct gctgggcatc     1800

tggggctgta gcggcaagct gatctgtacc accgccgtgc cttggaatag cagctggagc     1860

aacaagagcc aggaggacat ctgggacaac atgacctgga tgcagtggga ccgggagatc     1920

agcaactaca ccgacaccat ctacaggctg ctggaggaca gccagaacca gcaggagaag     1980

aacgagaagg acctgctggc cctggacagc tggaagaacc tgtggaactg gttcgacatc     2040

accaactggc tgtggtacat caagatcttc atcatgattg tgggcggcct gatcggcctg     2100

agaatcatct tcgccgtgct gagcatctga tagcggccgc                           2140


<210>  140
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype C consensus Envelope protein sequence construct

<400>  140

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Arg Gly Ile Leu Arg Asn Cys Gln Gln Trp Trp Ile 
            20                  25                  30          


Trp Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Met Gly 
        35                  40                  45              


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
    50                  55                  60                  


Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu 
65                  70                  75                  80  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Arg Asn Asn Val Asn Asn Asn Asn Thr Met Lys Glu Glu 
145                 150                 155                 160 


Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Leu Arg Asp Lys Lys 
                165                 170                 175     


Gln Lys Val Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asn 
            180                 185                 190         


Glu Lys Asn Asn Ser Asn Asp Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
        195                 200                 205             


Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile 
    210                 215                 220                 


His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys 
225                 230                 235                 240 


Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn 
        275                 280                 285             


Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Ser Val Glu Ile Val 
    290                 295                 300                 


Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro 
305                 310                 315                 320 


Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Ile Ser Glu Glu Lys Trp Asn Lys Thr Leu Gln Arg 
            340                 345                 350         


Val Ser Glu Lys Leu Lys Glu His Phe Pro Asn Lys Thr Ile Lys Phe 
        355                 360                 365             


Ala Pro Ser Ser Gly Gly Arg Leu Glu Ile Thr Thr His Ser Phe Asn 
    370                 375                 380                 


Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Lys Leu Phe Asn Ser 
385                 390                 395                 400 


Thr Tyr Met Pro Asn Ser Thr Asn Asn Thr Asn Thr Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Glu Gly Asn Ile Thr Cys Lys Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Asn Asp Thr Asn 
    450                 455                 460                 


Asp Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly 
                485                 490                 495     


Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg 
            500                 505                 510         


Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly 
        515                 520                 525             


Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln 
    530                 535                 540                 


Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile 
545                 550                 555                 560 


Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
                565                 570                 575     


Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln 
            580                 585                 590         


Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala 
        595                 600                 605             


Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Glu Asp Ile Trp 
    610                 615                 620                 


Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr 
625                 630                 635                 640 


Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys 
                645                 650                 655     


Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn 
            660                 665                 670         


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met 
        675                 680                 685             


Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser 
    690                 695                 700                 


Ile 
705 


<210>  141
<211>  2089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype D consensus Envelope DNA sequence construct

<400>  141
gggcatcaag cggaattacc agcacctgtg gaagtggggc accatgctgc tgggcatgct       60

gatgacctgc agcgtggccg agaacctgtg ggtgaccgtg tactacggcg tgcctgtgtg      120

gaaggaagcc accaccaccc tgttctgcgc cagcgatgcc aagagctaca agaccgaggc      180

ccacaatatc tgggccaccc acgcctgcgt gcctaccgat cccaaccctc aggagatcga      240

gctggagaac gtgaccgaga acttcaacat gtggaagaac aacatggtgg agcagatgca      300

cgaggacatc atcagcctgt gggaccagag cctgaagcct tgcgtgaagc tgacccctct      360

gtgcgtgacc ctgaactgca ccgacggcat gaggaacgac accaacgata ccaacgtgac      420

catggaggag ggcgagatga agaactgcag cttcaacatc accaccgaag tgcgggacaa      480

gaagaagcag gtgcacgccc tgttctacaa gctggacgtg gtgcccatcg acgacaacaa      540

caccaacaac agcaactacc ggctgatcaa ctgcaacacc agcgccatca cccaggcctg      600

ccccaaagtg accttcgagc ccatccccat ccactactgc gcccctgccg gcttcgccat      660

cctgaagtgc aaggataaga agttcaacgg caccggcccc tgcaagaatg tgagcaccgt      720

gcagtgcacc cacggcatca gacccgtggt gtccacccag ctgctgctga acggcagcct      780

ggccgaggag gagatcatca tccggagcga gaacctgacc aacaacgcca agatcatcat      840

tgtgcagctg aacgagagcg tgaccatcaa ttgcacccgg ccctacaaca atacccggaa      900

gcgcatcccc atcggcctgg gccaggcctt ctacaccacc agaggcatca tcggcgacat      960

cagacaggcc cactgcaata tcagcggagc cgagtggaat aagaccctgc agcaggtggc     1020

caagaagctg ggcgacctgc tgaacaagac caccatcatc ttcaagccta gcagcggcgg     1080

cagacctaga atcaccaccc acagcttcaa ttgtggcggc gagttcttct actgcaatac     1140

cagccggctg ttcaacagca cctggagcaa gaacagcacc agcaactcca ccaaggagaa     1200

caacaccatc accctgccct gccggatcaa gcagatcatc aatatgtggc agggagtggg     1260

caaggccatg tacgcccctc ccatcgaggg cctgatcaag tgcagcagca acatcaccgg     1320

cctgctgctg accagagatg gcggagccaa caactcccac aacgagacct tcagacctgg     1380

cggcggagac atgagggaca actggcggag cgagctgtac aagtacaaag tggtgaagat     1440

cgagcccctg ggcgtggccc ccaccagagc caagagaaga gtggtggagc gggagaagag     1500

agccatcgga ctgggcgcca tgttcctggg cttcctggga gccgccggaa gcaccatggg     1560

agccgccagc ctgaccctga ccgtgcaggc cagacagctg ctgagcggca tcgtgcagca     1620

gcagaacaac ctgctgagag ccattgaggc ccagcagcac ctgctgcagc tgacagtgtg     1680

gggcattaag cagctgcagg ccaggattct ggccgtggag cgctacctga aggatcagca     1740

gctgctggga atctggggct gcagcggcaa gcacatctgc accaccaccg tgccttggaa     1800

tagcagctgg agcaacaaga gcctggacga gatctggaac aacatgacct ggatggagtg     1860

ggagagggag atcgacaact acaccggcct gatctacagc ctgatcgagg agagccagac     1920

ccagcaggag aagaacgagc aggagctgct ggagctggac aagtgggcca gcctgtggaa     1980

ctggttcagc atcacccagt ggctgtggta catcaagatc ttcatcatga ttgtgggcgg     2040

cctgatcggc ctgagaatcg tgttcgccgt gctgagcctg tgactcgag                 2089


<210>  142
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype D consensus Envelope protein sequence construct

<400>  142

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Arg Gly Ile Lys Arg Asn Tyr Gln His Leu Trp Lys 
            20                  25                  30          


Trp Gly Thr Met Leu Leu Gly Met Leu Met Thr Cys Ser Val Ala Glu 
        35                  40                  45              


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
    50                  55                  60                  


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Lys Thr Glu 
65                  70                  75                  80  


Ala His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Ile Glu Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Thr Asp Gly Met Arg Asn Asp Thr Asn Asp Thr Asn Val 
145                 150                 155                 160 


Thr Met Glu Glu Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr 
                165                 170                 175     


Glu Val Arg Asp Lys Lys Lys Gln Val His Ala Leu Phe Tyr Lys Leu 
            180                 185                 190         


Asp Val Val Pro Ile Asp Asp Asn Asn Thr Asn Asn Ser Asn Tyr Arg 
        195                 200                 205             


Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val 
    210                 215                 220                 


Thr Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
225                 230                 235                 240 


Ile Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys 
                245                 250                 255     


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
            260                 265                 270         


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile 
        275                 280                 285             


Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu 
    290                 295                 300                 


Asn Glu Ser Val Thr Ile Asn Cys Thr Arg Pro Tyr Asn Asn Thr Arg 
305                 310                 315                 320 


Lys Arg Ile Pro Ile Gly Leu Gly Gln Ala Phe Tyr Thr Thr Arg Gly 
                325                 330                 335     


Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Gly Ala Glu 
            340                 345                 350         


Trp Asn Lys Thr Leu Gln Gln Val Ala Lys Lys Leu Gly Asp Leu Leu 
        355                 360                 365             


Asn Lys Thr Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Arg Pro Arg 
    370                 375                 380                 


Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
385                 390                 395                 400 


Thr Ser Arg Leu Phe Asn Ser Thr Trp Ser Lys Asn Ser Thr Ser Asn 
                405                 410                 415     


Ser Thr Lys Glu Asn Asn Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln 
            420                 425                 430         


Ile Ile Asn Met Trp Gln Gly Val Gly Lys Ala Met Tyr Ala Pro Pro 
        435                 440                 445             


Ile Glu Gly Leu Ile Lys Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu 
    450                 455                 460                 


Thr Arg Asp Gly Gly Ala Asn Asn Ser His Asn Glu Thr Phe Arg Pro 
465                 470                 475                 480 


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
                485                 490                 495     


Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys 
            500                 505                 510         


Arg Arg Val Val Glu Arg Glu Lys Arg Ala Ile Gly Leu Gly Ala Met 
        515                 520                 525             


Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser 
    530                 535                 540                 


Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln 
545                 550                 555                 560 


Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu 
                565                 570                 575     


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala 
            580                 585                 590         


Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys 
        595                 600                 605             


Ser Gly Lys His Ile Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp 
    610                 615                 620                 


Ser Asn Lys Ser Leu Asp Glu Ile Trp Asn Asn Met Thr Trp Met Glu 
625                 630                 635                 640 


Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Ser Leu Ile 
                645                 650                 655     


Glu Glu Ser Gln Thr Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 
            660                 665                 670         


Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Ser Ile Thr Gln Trp 
        675                 680                 685             


Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly 
    690                 695                 700                 


Leu Arg Ile Val Phe Ala Val Leu Ser Leu 
705                 710                 


<210>  143
<211>  1049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Nef-Rev DNA sequence construct

<400>  143
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggccgctgc caccagagtg       60

cacagcagca agagaagcgt ggtgggttgg cctacagtgc gggagaggat gagaagagcc      120

gagcctgccg ccgatggagt gggcgccgtg tctagagatc tggagaagca cggcgccatc      180

accagcagca ataccgccgc caacaatgcc gactgcgcct ggctggaggc ccaggaggag      240

gaggaagtgg gcttccctgt gagagcccag gtggccctga gagccatgac ctacaaggcc      300

gccgtggatc tgagccactt cctgaaggag aagggcggcc tggagggcct gatctacagc      360

cagaagcggc aggacatcct ggatctgtgg gtgtaccaca cccagggcta cttccccgac      420

tggcagaatt acacccctgg ccctggcatc agataccctc tgaccttcgg ctggtgcttc      480

aagctggtgc ctgtggagcc tgagaaagtg gaggaggcca acgagggcga gaacaattct      540

gccgcccacc ctatgagcct gcacggcatg gacgatcccg agagggaagt gctggtgtgg      600

aagttcgaca gcaggctggc cttccaccac atggccagag agctgcaccc cgagtactac      660

aaggactgcc ggggcaggaa gagaagaagc gccggcagaa gcggcgacag cgacgaggag      720

ctgctgaaaa cagtgcggct gatcaagttc ctgtaccaga gcaaccctcc tcccagcccc      780

gagggcacca gacaggcccg gagaaaccgg aggaggcggt ggagagagag gcagcggcag      840

atcagaagca tcagcgagtg gattctgagc acctacctgg gcagacccgc cgagcccgtg      900

cccctgcagc tgccccccct ggagagactg accctggact gcaacgagga ctgcggcacc      960

agcggcaccc agggagtggg cagcccccag atcctggtgg agagccctgc cgtgctggag     1020

agcggcacca aggagtgatg agcggccgc                                       1049


<210>  144
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Nef-Rev protein sequence construct

<400>  144

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Lys Arg Ser Val Val Gly Trp Pro Thr Val Arg Glu Arg 
            20                  25                  30          


Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala Val Ser Arg 
        35                  40                  45              


Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr Ala Ala Asn 
    50                  55                  60                  


Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu Val Gly 
65                  70                  75                  80  


Phe Pro Val Arg Ala Gln Val Ala Leu Arg Ala Met Thr Tyr Lys Ala 
                85                  90                  95      


Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu Glu Gly 
            100                 105                 110         


Leu Ile Tyr Ser Gln Lys Arg Gln Asp Ile Leu Asp Leu Trp Val Tyr 
        115                 120                 125             


His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro 
    130                 135                 140                 


Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys Leu Val Pro 
145                 150                 155                 160 


Val Glu Pro Glu Lys Val Glu Glu Ala Asn Glu Gly Glu Asn Asn Ser 
                165                 170                 175     


Ala Ala His Pro Met Ser Leu His Gly Met Asp Asp Pro Glu Arg Glu 
            180                 185                 190         


Val Leu Val Trp Lys Phe Asp Ser Arg Leu Ala Phe His His Met Ala 
        195                 200                 205             


Arg Glu Leu His Pro Glu Tyr Tyr Lys Asp Cys Arg Gly Arg Lys Arg 
    210                 215                 220                 


Arg Ser Ala Gly Arg Ser Gly Asp Ser Asp Glu Glu Leu Leu Lys Thr 
225                 230                 235                 240 


Val Arg Leu Ile Lys Phe Leu Tyr Gln Ser Asn Pro Pro Pro Ser Pro 
                245                 250                 255     


Glu Gly Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu 
            260                 265                 270         


Arg Gln Arg Gln Ile Arg Ser Ile Ser Glu Trp Ile Leu Ser Thr Tyr 
        275                 280                 285             


Leu Gly Arg Pro Ala Glu Pro Val Pro Leu Gln Leu Pro Pro Leu Glu 
    290                 295                 300                 


Arg Leu Thr Leu Asp Cys Asn Glu Asp Cys Gly Thr Ser Gly Thr Gln 
305                 310                 315                 320 


Gly Val Gly Ser Pro Gln Ile Leu Val Glu Ser Pro Ala Val Leu Glu 
                325                 330                 335     


Ser Gly Thr Lys Glu 
            340     


<210>  145
<211>  1863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gag consensus DNA sequence of subtype A, B, C and D construct

<400>  145
ggatccgcca ccatggactg gacctggatt ctgtttctgg tcgccgccgc cacaagagtg       60

cacagcggcg ccagagccag cgtgctgtcc ggcggcaagc tggacgcctg ggagaagatc      120

agactgaggc ctggcggcaa gaagaagtac cggctgaagc accttgtgtg ggccagcaga      180

gagctggaga gattcgccct gaatcctggc ctgctggaga ccagcgaggg ctgtaagcag      240

atcatcggcc agctgcagcc cgccctgcag accggcagcg aggagctgag aagcctgtac      300

aacaccgtgg ccaccctgta ctgcgtgcac gagaagatcg aggtgaagga caccaaggag      360

gccctggaca agatcgagga ggagcagaac aagagcaagc agaaggccca gcaggccgcc      420

gccgacaccg gcaacagcag ccaggtgtcc cagaactacc ccatcgtgca gaatctgcag      480

ggccagatgg tgcaccaggc catcagcccc agaaccctga atgcctgggt gaaggtgatc      540

gaggagaagg ccttcagccc tgaggtgatc cctatgttca gcgccctgag cgagggcgcc      600

acacctcagg acctgaacac catgctgaac acagtggggg gccaccaggc cgccatgcag      660

atgctgaagg ataccatcaa cgaggaggcc gccgagtggg acagactgca ccccgtgcac      720

gccggaccta tcgcccctgg ccagatgaga gagcccagag gcagcgacat cgccggcacc      780

acctccaccc tgcaagagca gatcggctgg atgaccagca acccccccat ccctgtgggc      840

gacatctaca agcggtggat catcctgggc ctgaacaaga ttgtgaggat gtacagcccc      900

gtgtccatcc tggatatcag gcagggcccc aaggagccct tcagagacta cgtggaccgg      960

ttcttcaaga ccctgagagc cgagcaggcc agccaggacg tgaagaactg gatgaccgag     1020

accctgctgg tgcagaacgc caaccccgac tgtaagacca tcctgagagc cctgggccct     1080

ggcgccaccc tggaggagat gatgaccgcc tgccagggag tgggcggacc cggccacaag     1140

gccagagtgc tggccgaggc catgagccag gccaccaaca gcaacatcat gatgcagcgg     1200

ggcaacttca gaggccccag gaggatcgtg aagtgcttca actgtggcaa ggagggccac     1260

atcgccagaa actgtagggc ccccaggaag aagggctgct ggaagtgtgg caaagagggg     1320

caccagatga aggactgtac cgagcggcag gccaatttcc tggggaagat ctggcccagc     1380

cacaagggca gacccggcaa tttcctgcag agcagacctg agcccaccgc ccctcccgcc     1440

gagagcttcg gcttcggcga ggagatcacc cccagcccca agcaggagcc caaggacaga     1500

gagctgtacc ctctggccag cctgaagagc ctgttcggca acgatcccct gagccagtac     1560

ccctacgacg tgcccgatta cgcctgagaa ttcgtaagta agtgtcatat gggagagctc     1620

gactagactg gacagccaat gacgggtaag agagtgacat ttctcactaa cctaagacag     1680

gagggccgtc aaagctactg cctaatccaa tgacgggtaa tagtgacaag aaatgtatca     1740

ctccaaccta agacaggcgc agcctccgag ggatgtgtct tttgtttttt ataattaaaa     1800

agggtgacat gtccggagcc gtgctgcccg gatgatgtct tggcctctgt ttgctgcggc     1860

cgc                                                                   1863


<210>  146
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gag consensus protein sequence of subtype A, B, C and D construct

<400>  146

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Lys Leu Asp Ala 
            20                  25                  30          


Trp Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu 
        35                  40                  45              


Lys His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn 
    50                  55                  60                  


Pro Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Gly Gln 
65                  70                  75                  80  


Leu Gln Pro Ala Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr 
                85                  90                  95      


Asn Thr Val Ala Thr Leu Tyr Cys Val His Glu Lys Ile Glu Val Lys 
            100                 105                 110         


Asp Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser 
        115                 120                 125             


Lys Gln Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln 
    130                 135                 140                 


Val Ser Gln Asn Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val 
145                 150                 155                 160 


His Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile 
                165                 170                 175     


Glu Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu 
            180                 185                 190         


Ser Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val 
        195                 200                 205             


Gly Gly His Gln Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu 
    210                 215                 220                 


Glu Ala Ala Glu Trp Asp Arg Leu His Pro Val His Ala Gly Pro Ile 
225                 230                 235                 240 


Ala Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr 
                245                 250                 255     


Thr Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Ser Asn Pro Pro 
            260                 265                 270         


Ile Pro Val Gly Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn 
        275                 280                 285             


Lys Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln 
    290                 295                 300                 


Gly Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr 
305                 310                 315                 320 


Leu Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu 
                325                 330                 335     


Thr Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg 
            340                 345                 350         


Ala Leu Gly Pro Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln 
        355                 360                 365             


Gly Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met 
    370                 375                 380                 


Ser Gln Ala Thr Asn Ser Asn Ile Met Met Gln Arg Gly Asn Phe Arg 
385                 390                 395                 400 


Gly Pro Arg Arg Ile Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
                405                 410                 415     


Ile Ala Arg Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
            420                 425                 430         


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
        435                 440                 445             


Phe Leu Gly Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe 
    450                 455                 460                 


Leu Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Gly 
465                 470                 475                 480 


Phe Gly Glu Glu Ile Thr Pro Ser Pro Lys Gln Glu Pro Lys Asp Arg 
                485                 490                 495     


Glu Leu Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp Pro 
            500                 505                 510         


Leu Ser Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
        515                 520                 


<210>  147
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype A consensus Envelope protein sequence

<400>  147

Ser Arg Val Met Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Ile Ile Ile Cys Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asn Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Val Thr Thr Asn Ile Met Lys Gly Glu Ile 
    130                 135                 140                 


Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln 
145                 150                 155                 160 


Lys Val Tyr Ser Leu Phe Tyr Lys Leu Asp Val Val Gln Ile Asn Lys 
                165                 170                 175     


Ser Asn Ser Ser Ser Gln Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala 
            180                 185                 190         


Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Glu 
    210                 215                 220                 


Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Leu Ala Glu Glu Glu Val Met Ile Arg Ser Glu Asn Ile Thr Asn Asn 
            260                 265                 270         


Ala Lys Asn Ile Ile Val Gln Leu Thr Lys Pro Val Lys Ile Asn Cys 
        275                 280                 285             


Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly 
    290                 295                 300                 


Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala 
305                 310                 315                 320 


His Cys Asn Val Ser Arg Thr Glu Trp Asn Glu Thr Leu Gln Lys Val 
                325                 330                 335     


Ala Lys Gln Leu Arg Lys Tyr Phe Asn Asn Lys Thr Ile Ile Phe Thr 
            340                 345                 350         


Asn Ser Ser Gly Gly Arg Leu Arg Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr 
    370                 375                 380                 


Trp Asn Gly Asn Gly Thr Lys Lys Lys Asn Ser Thr Glu Ser Asn Asp 
385                 390                 395                 400 


Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
                405                 410                 415     


Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile Arg 
            420                 425                 430         


Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asp 
        435                 440                 445             


Asn Asn Ser Lys Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
    450                 455                 460                 


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
465                 470                 475                 480 


Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg 
                485                 490                 495     


Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Ser 
        595                 600                 605             


Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser 
    610                 615                 620                 


Asn Tyr Thr Asp Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Asn 
                645                 650                 655     


Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile 
            660                 665                 670         


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala 
        675                 680                 685             


Val Leu Ser Val 
    690         


<210>  148
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Envelope protein sequence

<400>  148

Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp Gly 
1               5                   10                  15      


Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Lys Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Asp Leu Ser Gly Glu Lys Met Glu Lys Gly Glu Ile Lys Asn 
    130                 135                 140                 


Cys Ser Phe Asn Ile Thr Thr Ser Ile Arg Asp Lys Val Gln Lys Glu 
145                 150                 155                 160 


Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Asn 
                165                 170                 175     


Thr Ser Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln Ala 
            180                 185                 190         


Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro 
        195                 200                 205             


Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr 
    210                 215                 220                 


Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg 
225                 230                 235                 240 


Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu 
                245                 250                 255     


Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile 
            260                 265                 270         


Ile Val Gln Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn 
        275                 280                 285             


Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Gln Ala Phe Tyr 
    290                 295                 300                 


Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile 
305                 310                 315                 320 


Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Lys Lys Leu 
                325                 330                 335     


Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser Ser Gly 
            340                 345                 350         


Gly Arg Pro Arg Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe 
        355                 360                 365             


Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Asn Val Asn 
    370                 375                 380                 


Gly Thr Trp Asn Asn Asn Thr Glu Gly Asn Asp Thr Ile Thr Leu Pro 
385                 390                 395                 400 


Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala 
                405                 410                 415     


Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile 
            420                 425                 430         


Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Thr Asn Glu 
        435                 440                 445             


Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    450                 455                 460                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
465                 470                 475                 480 


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
                485                 490                 495     


Val Gly Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
            500                 505                 510         


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
        515                 520                 525             


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
    530                 535                 540                 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
545                 550                 555                 560 


Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
                565                 570                 575     


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val 
            580                 585                 590         


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Asp Glu Ile Trp Asp 
        595                 600                 605             


Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Ser 
    610                 615                 620                 


Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
625                 630                 635                 640 


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
                645                 650                 655     


Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile 
            660                 665                 670         


Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
        675                 680                 685             


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
    690                 695         


<210>  149
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype C consensus Envelope protein sequence

<400>  149

Arg Val Arg Gly Ile Leu Arg Asn Cys Gln Gln Trp Trp Ile Trp Gly 
1               5                   10                  15      


Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Met Gly Asn Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Arg Asn Asn Val Asn Asn Asn Asn Thr Met Lys Glu Glu Ile Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Ile Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys 
145                 150                 155                 160 


Val Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asn Glu Lys 
                165                 170                 175     


Asn Asn Ser Asn Asp Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile 
            180                 185                 190         


Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr 
        195                 200                 205             


Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe 
    210                 215                 220                 


Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His 
225                 230                 235                 240 


Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
                245                 250                 255     


Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala 
            260                 265                 270         


Lys Thr Ile Ile Val His Leu Asn Glu Ser Val Glu Ile Val Cys Thr 
        275                 280                 285             


Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln 
    290                 295                 300                 


Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His 
305                 310                 315                 320 


Cys Asn Ile Ser Glu Glu Lys Trp Asn Lys Thr Leu Gln Arg Val Ser 
                325                 330                 335     


Glu Lys Leu Lys Glu His Phe Pro Asn Lys Thr Ile Lys Phe Ala Pro 
            340                 345                 350         


Ser Ser Gly Gly Arg Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg 
        355                 360                 365             


Gly Glu Phe Phe Tyr Cys Asn Thr Ser Lys Leu Phe Asn Ser Thr Tyr 
    370                 375                 380                 


Met Pro Asn Ser Thr Asn Asn Thr Asn Thr Thr Ile Thr Leu Pro Cys 
385                 390                 395                 400 


Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met 
                405                 410                 415     


Tyr Ala Pro Pro Ile Glu Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr 
            420                 425                 430         


Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Asn Asp Thr Asn Asp Thr 
        435                 440                 445             


Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser 
    450                 455                 460                 


Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala 
465                 470                 475                 480 


Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val 
                485                 490                 495     


Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr 
            500                 505                 510         


Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
        515                 520                 525             


Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala 
    530                 535                 540                 


Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
545                 550                 555                 560 


Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu 
                565                 570                 575     


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro 
            580                 585                 590         


Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Glu Asp Ile Trp Asp Asn 
        595                 600                 605             


Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asp Thr 
    610                 615                 620                 


Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu 
625                 630                 635                 640 


Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn Trp Phe 
                645                 650                 655     


Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
            660                 665                 670         


Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile 
        675                 680                 685         


<210>  150
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype D consensus Envelope protein sequence

<400>  150

Arg Val Arg Gly Ile Lys Arg Asn Tyr Gln His Leu Trp Lys Trp Gly 
1               5                   10                  15      


Thr Met Leu Leu Gly Met Leu Met Thr Cys Ser Val Ala Glu Asn Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Lys Thr Glu Ala His 
    50                  55                  60                  


Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Ile Glu Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Asp Gly Met Arg Asn Asp Thr Asn Asp Thr Asn Val Thr Met 
    130                 135                 140                 


Glu Glu Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Val 
145                 150                 155                 160 


Arg Asp Lys Lys Lys Gln Val His Ala Leu Phe Tyr Lys Leu Asp Val 
                165                 170                 175     


Val Pro Ile Asp Asp Asn Asn Thr Asn Asn Ser Asn Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Thr Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser 
            260                 265                 270         


Glu Asn Leu Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Glu 
        275                 280                 285             


Ser Val Thr Ile Asn Cys Thr Arg Pro Tyr Asn Asn Thr Arg Lys Arg 
    290                 295                 300                 


Ile Pro Ile Gly Leu Gly Gln Ala Phe Tyr Thr Thr Arg Gly Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Gly Ala Glu Trp Asn 
                325                 330                 335     


Lys Thr Leu Gln Gln Val Ala Lys Lys Leu Gly Asp Leu Leu Asn Lys 
            340                 345                 350         


Thr Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Arg Pro Arg Ile Thr 
        355                 360                 365             


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
    370                 375                 380                 


Arg Leu Phe Asn Ser Thr Trp Ser Lys Asn Ser Thr Ser Asn Ser Thr 
385                 390                 395                 400 


Lys Glu Asn Asn Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile 
                405                 410                 415     


Asn Met Trp Gln Gly Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Glu 
            420                 425                 430         


Gly Leu Ile Lys Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Ala Asn Asn Ser His Asn Glu Thr Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
465                 470                 475                 480 


Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys Arg Arg 
                485                 490                 495     


Val Val Glu Arg Glu Lys Arg Ala Ile Gly Leu Gly Ala Met Phe Leu 
            500                 505                 510         


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr 
        515                 520                 525             


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
    530                 535                 540                 


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 
545                 550                 555                 560 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu 
                565                 570                 575     


Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
            580                 585                 590         


Lys His Ile Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp Ser Asn 
        595                 600                 605             


Lys Ser Leu Asp Glu Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu 
    610                 615                 620                 


Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Ser Leu Ile Glu Glu 
625                 630                 635                 640 


Ser Gln Thr Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp 
                645                 650                 655     


Lys Trp Ala Ser Leu Trp Asn Trp Phe Ser Ile Thr Gln Trp Leu Trp 
            660                 665                 670         


Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg 
        675                 680                 685             


Ile Val Phe Ala Val Leu Ser Leu 
    690                 695     


<210>  151
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Nef-Rev protein sequence

<400>  151

Ser Lys Arg Ser Val Val Gly Trp Pro Thr Val Arg Glu Arg Met Arg 
1               5                   10                  15      


Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala Val Ser Arg Asp Leu 
            20                  25                  30          


Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr Ala Ala Asn Asn Ala 
        35                  40                  45              


Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu Val Gly Phe Pro 
    50                  55                  60                  


Val Arg Ala Gln Val Ala Leu Arg Ala Met Thr Tyr Lys Ala Ala Val 
65                  70                  75                  80  


Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu Glu Gly Leu Ile 
                85                  90                  95      


Tyr Ser Gln Lys Arg Gln Asp Ile Leu Asp Leu Trp Val Tyr His Thr 
            100                 105                 110         


Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro Gly Ile 
        115                 120                 125             


Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys Leu Val Pro Val Glu 
    130                 135                 140                 


Pro Glu Lys Val Glu Glu Ala Asn Glu Gly Glu Asn Asn Ser Ala Ala 
145                 150                 155                 160 


His Pro Met Ser Leu His Gly Met Asp Asp Pro Glu Arg Glu Val Leu 
                165                 170                 175     


Val Trp Lys Phe Asp Ser Arg Leu Ala Phe His His Met Ala Arg Glu 
            180                 185                 190         


Leu His Pro Glu Tyr Tyr Lys Asp Cys Arg Gly Arg Lys Arg Arg Ser 
        195                 200                 205             


Ala Gly Arg Ser Gly Asp Ser Asp Glu Glu Leu Leu Lys Thr Val Arg 
    210                 215                 220                 


Leu Ile Lys Phe Leu Tyr Gln Ser Asn Pro Pro Pro Ser Pro Glu Gly 
225                 230                 235                 240 


Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg Gln 
                245                 250                 255     


Arg Gln Ile Arg Ser Ile Ser Glu Trp Ile Leu Ser Thr Tyr Leu Gly 
            260                 265                 270         


Arg Pro Ala Glu Pro Val Pro Leu Gln Leu Pro Pro Leu Glu Arg Leu 
        275                 280                 285             


Thr Leu Asp Cys Asn Glu Asp Cys Gly Thr Ser Gly Thr Gln Gly Val 
    290                 295                 300                 


Gly Ser Pro Gln Ile Leu Val Glu Ser Pro Ala Val Leu Glu Ser Gly 
305                 310                 315                 320 


Thr Lys Glu 
            


<210>  152
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gag consensus protein sequence of subtype A, B, C and D

<400>  152

Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Lys Leu Asp Ala Trp Glu 
1               5                   10                  15      


Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys His 
            20                  25                  30          


Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn Pro Gly 
        35                  40                  45              


Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Gly Gln Leu Gln 
    50                  55                  60                  


Pro Ala Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn Thr 
65                  70                  75                  80  


Val Ala Thr Leu Tyr Cys Val His Glu Lys Ile Glu Val Lys Asp Thr 
                85                  90                  95      


Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys Gln 
            100                 105                 110         


Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val Ser 
        115                 120                 125             


Gln Asn Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln 
    130                 135                 140                 


Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu 
145                 150                 155                 160 


Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu 
                165                 170                 175     


Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly 
            180                 185                 190         


His Gln Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu Ala 
        195                 200                 205             


Ala Glu Trp Asp Arg Leu His Pro Val His Ala Gly Pro Ile Ala Pro 
    210                 215                 220                 


Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser 
225                 230                 235                 240 


Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Ser Asn Pro Pro Ile Pro 
                245                 250                 255     


Val Gly Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile 
            260                 265                 270         


Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly Pro 
        275                 280                 285             


Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg 
    290                 295                 300                 


Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr Leu 
305                 310                 315                 320 


Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg Ala Leu 
                325                 330                 335     


Gly Pro Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val 
            340                 345                 350         


Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser Gln 
        355                 360                 365             


Ala Thr Asn Ser Asn Ile Met Met Gln Arg Gly Asn Phe Arg Gly Pro 
    370                 375                 380                 


Arg Arg Ile Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala 
385                 390                 395                 400 


Arg Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys 
                405                 410                 415     


Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu 
            420                 425                 430         


Gly Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln 
        435                 440                 445             


Ser Arg Pro Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Gly Phe Gly 
    450                 455                 460                 


Glu Glu Ile Thr Pro Ser Pro Lys Gln Glu Pro Lys Asp Arg Glu Leu 
465                 470                 475                 480 


Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp Pro Leu Ser 
                485                 490                 495     


Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            500                 505     


<210>  153
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-1074_IgG1_heavy

<400>  153

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Val Thr Cys Ser Val Ser Gly Asp Ser Met 
        35                  40                  45              


Asn Asn Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Ser Asp Arg Glu Ser Ala Thr Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Asn Ser Arg Val Val Ile Ser Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Leu Ser Leu Lys Leu Asn Ser Val Thr Pro Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Thr Ala Arg Arg Gly Gln Arg Ile Tyr Gly Val Val Ser 
        115                 120                 125             


Phe Gly Glu Phe Phe Tyr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly 
    130                 135                 140                 


Thr Thr Val Thr Val Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
145                 150                 155                 160 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                165                 170                 175     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            180                 185                 190         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        195                 200                 205             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    210                 215                 220                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
225                 230                 235                 240 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
                245                 250                 255     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    290                 295                 300                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 480 


<210>  154
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074_IgG1_heavy

<400>  154
ggatccgcca ccatggattg gacttggagg attctgtttc tggtcgccgc cgctaccggg       60

actcacgctc aggtgcagct gcaggagagt gggccaggac tggtgaagcc tagcgagaca      120

ctgagcgtga catgctccgt gagcggcgac tccatgaaca attactattg gacctggatc      180

agacagtctc ctggcaaggg cctggagtgg atcggctaca tctccgacag agagtccgcc      240

acatataatc cttccctgaa ctcccgcgtg gtaatcagca gagataccag caagaaccag      300

ctgagcctga agctgaatag cgtgacccca gccgatacag ccgtgtatta ctgcgccaca      360

gccaggcgcg gccagagaat ctacggcgtg gtgtcctttg gcgagttttt ctactactac      420

tccatggacg tgtggggcaa gggcaccaca gtgaccgtgt ccgcctctac caagggccca      480

agcgtgtttc ccctggcccc atcttccaag tctacctccg gcggcacagc cgccctgggc      540

tgcctggtga aggattactt tccagagcct gtgacagtgt cctggaattc cggcgccctg      600

acctccggcg tgcacacctt tcctgccgtg ctgcagtctt ccggcctgta ctctctgtcc      660

agcgtggtga cagtgccaag ctcttccctg ggcacccaga catacatctg caatgtgaac      720

cacaagccct ccaacaccaa ggtggacaag aaggtggagc caaagagctg cgacaagacc      780

cacacctgtc caccttgccc agccccagag ctgctgggcg gccccagcgt gttcctgttc      840

ccacctaagc caaaggatac cctgatgatc tcccgcaccc cagaggtgac ctgcgtggtg      900

gtggacgtgt ctcacgagga ccctgaggtg aagtttaact ggtacgtgga tggcgtggag      960

gtgcacaatg ccaagaccaa gcctcgggag gagcagtaca actccacata cagggtggtg     1020

tctgtgctga cagtgctgca ccaggattgg ctgaacggca aggagtacaa gtgtaaggtg     1080

tctaacaagg ccctgccagc cccaatcgag aagaccatct ccaaggccaa gggccagccc     1140

cgggagccac aggtgtatac cctgccacct agccgggatg agctgaccaa gaaccaggtg     1200

tccctgacat gtctggtgaa gggcttttac ccatccgaca tcgccgtgga gtgggagtcc     1260

aacggccagc ccgagaacaa ttacaagaca acccctccag tgctggactc tgatggcagc     1320

ttctttctgt actccaagct gacagtggat aagtctagat ggcagcaggg caacgtgttt     1380

tcctgctctg tgatgcacga ggccctgcac aatcactaca cccagaagtc cctgagcctg     1440

tctcccggca agtgataact cgag                                            1464


<210>  155
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-1074_IgG1_light

<400>  155

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Ser Tyr Val Arg Pro Leu Ser Val Ala Leu Gly Glu 
            20                  25                  30          


Thr Ala Arg Ile Ser Cys Gly Arg Gln Ala Leu Gly Ser Arg Ala Val 
        35                  40                  45              


Gln Trp Tyr Gln His Arg Pro Gly Gln Ala Pro Ile Leu Leu Ile Tyr 
    50                  55                  60                  


Asn Asn Gln Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Thr 
65                  70                  75                  80  


Pro Asp Ile Asn Phe Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Val 
                85                  90                  95      


Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys His Met Trp Asp Ser Arg 
            100                 105                 110         


Ser Gly Phe Ser Trp Ser Phe Gly Gly Ala Thr Arg Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  156
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074_IgG1_light

<400>  156
ggatccgcca ccatggcctg gacacccctg tttctgttcc tgctgacctg ctgccctggc       60

ggctccaact cctcttatgt gagaccactg tccgtggccc tgggcgagac agccagaatc      120

tcctgtggca gacaggccct gggctccaga gccgtgcagt ggtatcagca cagaccaggc      180

caggccccta tcctgctgat ctacaacaat caggacagac catccggcat cccagagaga      240

ttttccggca cccccgatat caacttcggc accagagcca ccctgacaat cagcggcgtg      300

gaggccggcg atgaggccga ttattactgt cacatgtggg actcccggag cggcttttcc      360

tggtcttttg gcggcgccac aagactgacc gtgctgggcc agcctaaggc cgccccttct      420

gtgacactgt ttccacccag ctctgaggag ctgcaggcca ataaggccac actggtgtgc      480

ctgatctccg acttctaccc aggcgccgtg accgtggcct ggaaggccga ttcctctcca      540

gtgaaggccg gcgtggagac aaccacccca agcaagcagt ccaacaacaa gtatgccgcc      600

tcttcttacc tgtccctgac acctgagcag tggaagtctc acaagagcta ctcctgtcag      660

gtcacccatg agggcagcac agtggaaaaa accgtcgcac caacagaatg tagctgataa      720

ctcgag                                                                 726


