                         SEQUENCE LISTING

<110>  Icell Kealex Therapeutics
 
<120>  MUTANT VACCINIA VIRUSES AND USE THEREOF

<130>  190011001PCT

<160>  174   

<170>  PatentIn version 3.5

<210>  1
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:1, Mutant H3L amino acid sequence

<400>  1

Met Ala Ala Ala Lys Thr Pro Val Ile Val Val Pro Val Ala Ala Ala 
1               5                   10                  15      


Leu Pro Ser Glu Thr Phe Pro Asn Val His Glu His Ile Asn Asp Gln 
            20                  25                  30          


Ala Ala Ala Asp Val Ala Asp Ala Glu Val Met Ala Ala Lys Arg Asn 
        35                  40                  45              


Val Val Val Ala Lys Asp Asp Pro Asp His Tyr Lys Asp Tyr Ala Phe 
    50                  55                  60                  


Ile Gln Trp Thr Gly Gly Asn Ile Arg Asn Asp Asp Lys Tyr Thr His 
65                  70                  75                  80  


Phe Phe Ser Gly Phe Cys Asn Thr Met Cys Thr Glu Glu Thr Lys Arg 
                85                  90                  95      


Asn Ile Ala Arg His Leu Ala Leu Trp Asp Ser Asn Phe Phe Thr Glu 
            100                 105                 110         


Leu Glu Asn Lys Lys Val Glu Tyr Val Val Ile Val Glu Asn Asp Asn 
        115                 120                 125             


Val Ile Ala Ala Ile Ala Phe Leu Ala Pro Val Leu Lys Ala Met His 
    130                 135                 140                 


Asp Lys Lys Ile Asp Ile Leu Gln Met Ala Glu Ala Ile Thr Gly Asn 
145                 150                 155                 160 


Ala Val Lys Thr Glu Ala Ala Ala Asp Lys Asn His Ala Ile Phe Thr 
                165                 170                 175     


Tyr Thr Gly Gly Tyr Asp Val Ser Leu Ser Ala Tyr Ile Ile Arg Val 
            180                 185                 190         


Thr Thr Ala Leu Asn Ile Ala Asp Glu Ile Ile Lys Ser Gly Gly Leu 
        195                 200                 205             


Ser Ser Gly Phe Tyr Phe Glu Ile Ala Arg Ile Glu Asn Glu Met Lys 
    210                 215                 220                 


Ile Asn Ala Gln Ile Leu Asp Asn Ala Ala Lys Tyr Val Glu His Asp 
225                 230                 235                 240 


Pro Arg Leu Val Ala Glu His Arg Phe Ala Asn Met Ala Ala Ala Ala 
                245                 250                 255     


Trp Ser Arg Ile Gly Thr Ala Ala Thr Lys Arg Tyr Pro Gly Val Met 
            260                 265                 270         


Tyr Ala Phe Thr Thr Pro Leu Ile Ser Phe Phe Gly Leu Phe Asp Ile 
        275                 280                 285             


Asn Val Ile Gly Leu Ile Val Ile Leu Phe Ile Met Phe Met Leu Ile 
    290                 295                 300                 


Phe Asn Val Lys Ser Lys Leu Leu Trp Phe Leu Thr Gly Thr Phe Val 
305                 310                 315                 320 


Thr Ala Phe Ile 
                


<210>  2
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:2, mutant D8L amino acid sequence

<400>  2

Met Pro Gln Gln Leu Ser Pro Ile Asn Ile Glu Thr Lys Lys Ala Ile 
1               5                   10                  15      


Ser Asn Ala Arg Leu Lys Pro Leu Asp Ile His Tyr Asn Glu Ser Lys 
            20                  25                  30          


Pro Thr Thr Ile Gln Asn Thr Gly Ala Leu Val Ala Ile Asn Phe Ala 
        35                  40                  45              


Gly Gly Tyr Ile Ser Gly Gly Phe Leu Pro Asn Glu Tyr Val Leu Ser 
    50                  55                  60                  


Ser Leu His Ile Tyr Trp Gly Lys Glu Asp Asp Tyr Gly Ser Asn His 
65                  70                  75                  80  


Leu Ile Asp Val Tyr Lys Tyr Ser Gly Glu Ile Asn Leu Val His Trp 
                85                  90                  95      


Asn Ala Lys Lys Tyr Ser Ser Tyr Glu Glu Ala Ala Lys His Asp Asp 
            100                 105                 110         


Gly Leu Ile Ile Ile Ser Ile Phe Leu Gln Val Leu Asp His Lys Asn 
        115                 120                 125             


Val Tyr Phe Gln Lys Ile Val Asn Gln Leu Asp Ser Ile Arg Ser Ala 
    130                 135                 140                 


Asn Thr Ser Ala Pro Phe Asp Ser Val Phe Tyr Leu Asp Asn Leu Leu 
145                 150                 155                 160 


Pro Ser Lys Leu Asp Tyr Phe Thr Tyr Leu Gly Thr Thr Ile Asn His 
                165                 170                 175     


Ser Ala Asp Ala Val Trp Ile Ile Phe Pro Thr Pro Ile Asn Ile His 
            180                 185                 190         


Ser Asp Gln Leu Ser Lys Phe Arg Thr Leu Leu Ser Ser Ser Asn His 
        195                 200                 205             


Asp Gly Lys Pro His Tyr Ile Thr Glu Asn Tyr Ala Asn Pro Tyr Lys 
    210                 215                 220                 


Leu Asn Asp Asp Thr Gln Val Tyr Tyr Ser Gly Glu Ile Ile Arg Ala 
225                 230                 235                 240 


Ala Thr Thr Ser Pro Ala Arg Glu Asn Tyr Phe Met Arg Trp Leu Ser 
                245                 250                 255     


Asp Leu Arg Glu Thr Cys Phe Ser Tyr Tyr Gln Lys Tyr Ile Glu Glu 
            260                 265                 270         


Asn Lys Thr Phe Ala Ile Ile Ala Ile Val Phe Val Phe Ile Leu Thr 
        275                 280                 285             


Ala Ile Leu Phe Phe Met Ser Arg Arg Tyr Ser Arg Glu Lys Gln Asn 
    290                 295                 300                 


<210>  3
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:3, mutant A27L amino acid sequence

<400>  3

Met Asp Gly Thr Leu Phe Pro Gly Asp Asp Asp Leu Ala Ile Pro Ala 
1               5                   10                  15      


Thr Glu Phe Phe Ser Thr Lys Ala Ala Lys Ala Pro Glu Asp Lys Ala 
            20                  25                  30          


Ala Asp Ala Ala Ala Ala Ala Ala Asp Asp Asn Glu Glu Thr Leu Lys 
        35                  40                  45              


Gln Arg Leu Thr Asn Leu Glu Lys Lys Ile Thr Asn Val Thr Thr Lys 
    50                  55                  60                  


Phe Glu Gln Ile Glu Lys Cys Cys Lys Arg Asn Asp Glu Val Leu Phe 
65                  70                  75                  80  


Arg Leu Glu Asn His Ala Glu Thr Leu Arg Ala Ala Met Ile Ser Leu 
                85                  90                  95      


Ala Lys Lys Ile Asp Val Gln Thr Gly Arg Ala Ala Ala Glu 
            100                 105                 110 


<210>  4
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:4, mutant L1R amino acid sequence

<400>  4

Met Gly Ala Ala Ala Ser Ile Gln Thr Thr Val Asn Thr Leu Ser Glu 
1               5                   10                  15      


Arg Ile Ser Ser Lys Leu Glu Gln Ala Ala Ala Ala Ser Ala Ala Ala 
            20                  25                  30          


Ala Cys Ala Ile Glu Ile Gly Asn Phe Tyr Ile Arg Gln Asn His Gly 
        35                  40                  45              


Cys Asn Leu Thr Val Lys Asn Met Cys Ala Ala Ala Ala Ala Ala Gln 
    50                  55                  60                  


Leu Asp Ala Val Leu Ser Ala Ala Thr Glu Thr Tyr Ser Gly Leu Thr 
65                  70                  75                  80  


Pro Glu Gln Lys Ala Tyr Val Pro Ala Met Phe Thr Ala Ala Leu Asn 
                85                  90                  95      


Ile Gln Thr Ser Val Asn Thr Val Val Arg Asp Phe Glu Asn Tyr Val 
            100                 105                 110         


Lys Gln Thr Cys Asn Ser Ser Ala Val Val Asp Asn Ala Leu Ala Ile 
        115                 120                 125             


Gln Asn Val Ile Ile Asp Glu Cys Tyr Gly Ala Pro Gly Ser Pro Thr 
    130                 135                 140                 


Asn Leu Glu Phe Ile Asn Thr Gly Ser Ser Lys Gly Asn Cys Ala Ile 
145                 150                 155                 160 


Lys Ala Leu Met Gln Leu Thr Thr Lys Ala Thr Thr Gln Ile Ala Pro 
                165                 170                 175     


Lys Gln Val Ala Gly Thr Gly Val Gln Phe Tyr Met Ile Val Ile Gly 
            180                 185                 190         


Val Ile Ile Leu Ala Ala Leu Phe Met Tyr Tyr Ala Lys Arg Met Leu 
        195                 200                 205             


Phe Thr Ser Thr Asn Asp Lys Ile Lys Leu Ile Leu Ala Asn Lys Glu 
    210                 215                 220                 


Asn Val His Trp Thr Thr Tyr Met Asp Thr Phe Phe Arg Thr Ser Pro 
225                 230                 235                 240 


Met Val Ile Ala Thr Thr Asp Met Gln Asn 
                245                 250 


<210>  5
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:5, mutant H3L amino acid sequence

<400>  5

Met Ala Ala Ala Lys Thr Pro Val Ile Val Val Pro Val Ile Asp Arg 
1               5                   10                  15      


Leu Pro Ser Glu Thr Phe Pro Asn Val His Glu His Ile Asn Asp Gln 
            20                  25                  30          


Lys Phe Asp Asp Val Lys Asp Asn Glu Val Met Ala Glu Lys Arg Asn 
        35                  40                  45              


Val Val Val Val Lys Asp Asp Pro Asp His Tyr Lys Asp Tyr Ala Phe 
    50                  55                  60                  


Ile Gln Trp Thr Gly Gly Asn Ile Arg Asn Asp Asp Lys Tyr Thr His 
65                  70                  75                  80  


Phe Phe Ser Gly Phe Cys Asn Thr Met Cys Thr Glu Glu Thr Lys Arg 
                85                  90                  95      


Asn Ile Ala Arg His Leu Ala Leu Trp Asp Ser Asn Phe Phe Thr Glu 
            100                 105                 110         


Leu Glu Asn Lys Lys Val Glu Tyr Val Val Ile Val Glu Asn Asp Asn 
        115                 120                 125             


Val Ile Glu Asp Ile Thr Phe Leu Arg Pro Val Leu Lys Ala Met His 
    130                 135                 140                 


Asp Lys Lys Ile Asp Ile Leu Gln Met Arg Glu Ile Ile Thr Gly Asn 
145                 150                 155                 160 


Lys Val Lys Thr Glu Leu Val Met Asp Lys Asn His Ala Ile Phe Thr 
                165                 170                 175     


Tyr Thr Gly Gly Tyr Asp Val Ser Leu Ser Ala Tyr Ile Ile Arg Val 
            180                 185                 190         


Thr Thr Ala Leu Asn Ile Val Asp Glu Ile Ile Lys Ser Gly Gly Leu 
        195                 200                 205             


Ser Ser Gly Phe Tyr Phe Glu Ile Ala Arg Ile Glu Asn Glu Met Lys 
    210                 215                 220                 


Ile Asn Arg Gln Ile Leu Asp Asn Ala Ala Lys Tyr Val Glu His Asp 
225                 230                 235                 240 


Pro Arg Leu Val Ala Glu His Arg Phe Gly Trp Met Lys Pro Asn Phe 
                245                 250                 255     


Trp Phe Arg Ile Gly Pro Ala Thr Val Ile Arg Cys Pro Gly Val Lys 
            260                 265                 270         


Asn Ala Asn Thr Ala Pro Leu Ile Ser Phe Phe Gly Leu Phe Asp Ile 
        275                 280                 285             


Asn Val Ile Gly Leu Ile Val Ile Leu Phe Ile Met Phe Met Leu Ile 
    290                 295                 300                 


Phe Asn Val Lys Ser Lys Leu Leu Trp Phe Leu Thr Gly Thr Phe Val 
305                 310                 315                 320 


Thr Ala Phe Ile 
                


<210>  6
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D8L amino acid sequence (Alternate for this sequence: Seq 
       No. 174 - only different at position 43)

<400>  6

Met Pro Gln Gln Leu Ser Pro Ile Asn Ile Glu Thr Lys Lys Ala Ile 
1               5                   10                  15      


Ser Asn Ala Arg Leu Lys Pro Leu Asp Ile His Tyr Asn Glu Ser Lys 
            20                  25                  30          


Pro Thr Thr Ile Gln Asn Thr Gly Lys Leu Phe Trp Ile Asn Phe Lys 
        35                  40                  45              


Gly Gly Tyr Ile Ser Gly Trp Phe Leu Pro Asn Glu Tyr Val Leu Ser 
    50                  55                  60                  


Ser Leu His Ile Tyr Trp Gly Lys Glu Asp Asp Tyr Gly Ser Asn His 
65                  70                  75                  80  


Leu Ile Asp Val Tyr Lys Tyr Ser Gly Glu Ile Asn Leu Val His Trp 
                85                  90                  95      


Asn Lys Lys Lys Tyr Ser Ser Tyr Glu Glu Ala Lys Lys His Asp Asp 
            100                 105                 110         


Gly Leu Ile Ile Ile Ser Ile Phe Leu Gln Val Leu Asp His Lys Asn 
        115                 120                 125             


Val Tyr Phe Gln Lys Ile Val Asn Gln Leu Asp Ser Ile Arg Ser Thr 
    130                 135                 140                 


Asn Thr Ser Ala Pro Phe Asp Ser Val Phe Tyr Leu Asp Asn Leu Leu 
145                 150                 155                 160 


Pro Ser Lys Leu Asp Tyr Phe Ser Tyr Leu Gly Thr Thr Ile Asn His 
                165                 170                 175     


Tyr Ala Asp Ala Val Trp Ile Ile Phe Pro Thr Pro Ile Asn Ile His 
            180                 185                 190         


Ser Asp Gln Leu Ser Lys Tyr Arg Thr Leu Ser Ser Ser Ser Asn His 
        195                 200                 205             


Asp Gly Lys Thr His Tyr Ile Thr Glu Cys Tyr Arg Asn Leu Tyr Lys 
    210                 215                 220                 


Leu Asn Gly Asp Thr Gln Val Tyr Tyr Ser Gly Glu Ile Ile Arg Ala 
225                 230                 235                 240 


Ala Thr Thr Ser Pro Ala Arg Glu Asn Tyr Phe Met Arg Trp Leu Ser 
                245                 250                 255     


Asp Leu Arg Glu Thr Cys Phe Ser Tyr Tyr Gln Lys Tyr Ile Glu Glu 
            260                 265                 270         


Asn Lys Thr Phe Ala Ile Ile Ala Ile Val Phe Val Phe Ile Leu Thr 
        275                 280                 285             


Ala Ile Leu Phe Phe Met Ser Arg Arg Tyr Ser Arg Glu Lys Gln Asn 
    290                 295                 300                 


<210>  7
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:7, CD55-A27 amino acid sequence

<400>  7

Met Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu 
1               5                   10                  15      


Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys 
            20                  25                  30          


Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys 
        35                  40                  45              


Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser 
    50                  55                  60                  


Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr 
65                  70                  75                  80  


Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys 
                85                  90                  95      


Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys 
            100                 105                 110         


Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys 
        115                 120                 125             


Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro 
    130                 135                 140                 


Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly 
145                 150                 155                 160 


Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser 
                165                 170                 175     


Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys 
            180                 185                 190         


Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp 
        195                 200                 205             


His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe 
    210                 215                 220                 


Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu 
225                 230                 235                 240 


Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Gly Thr Leu Phe Pro 
            260                 265                 270         


Gly Asp Asp Asp Leu Ala Ile Pro Ala Thr Glu Phe Phe Ser Thr Lys 
        275                 280                 285             


Ala Ala Lys Ala Pro Glu Asp Lys Ala Ala Asp Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Asp Asp Asn Glu Glu Thr Leu Lys Gln Arg Leu Thr Asn Leu Glu 
305                 310                 315                 320 


Lys Lys Ile Thr Asn Val Thr Thr Lys Phe Glu Gln Ile Glu Lys Cys 
                325                 330                 335     


Cys Lys Arg Asn Asp Glu Val Leu Phe Arg Leu Glu Asn His Ala Glu 
            340                 345                 350         


Thr Leu Arg Ala Ala Met Ile Ser Leu Ala Lys Lys Ile Asp Val Gln 
        355                 360                 365             


Thr Gly Arg Ala Ala Ala Glu 
    370                 375 


<210>  8
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:8, FAP-CD3 amino acid sequence

<400>  8

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Glu Asn Ile Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Ser Ala Gln Ile Leu Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ala Ser Ser Val Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 
                165                 170                 175     


Arg Ala Ser Lys Ser Val Ser Thr Ser Ala Tyr Ser Tyr Met His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala 
        195                 200                 205             


Ser Asn Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Tyr Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Asp Asp Ile Lys 
        275                 280                 285             


Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys 
    290                 295                 300                 


Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
305                 310                 315                 320 


Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
                325                 330                 335     


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys 
            340                 345                 350         


Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
        355                 360                 365             


Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr 
    370                 375                 380                 


Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
385                 390                 395                 400 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            420                 425                 430         


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
        435                 440                 445             


Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    450                 455                 460                 


Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe 
465                 470                 475                 480 


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
                485                 490                 495     


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
            500                 505                 510         


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser 
        515                 520                 525     


<210>  9
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:9, BCMA-CD3 scFv amino acid sequence

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Val Asp Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro 
        275                 280                 285             


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
    290                 295                 300                 


Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
305                 310                 315                 320 


Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln 
                325                 330                 335     


Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr 
            340                 345                 350         


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro 
                405                 410                 415     


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
            420                 425                 430         


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly 
        435                 440                 445             


Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly 
    450                 455                 460                 


Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
465                 470                 475                 480 


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
                485                 490                 495     


Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            500                 505                 510         


Leu Lys Ser 
        515 


<210>  10
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:10, PD-1-ED-hIgG1-Fc amino acid sequence

<400>  10

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Phe Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Glu Pro Lys Ser Cys Asp 
                165                 170                 175     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            180                 185                 190         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        195                 200                 205             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    210                 215                 220                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
225                 230                 235                 240 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                245                 250                 255     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            260                 265                 270         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        275                 280                 285             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    290                 295                 300                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
305                 310                 315                 320 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                325                 330                 335     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            340                 345                 350         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        355                 360                 365             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    370                 375                 380                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
385                 390                 395                 400 


Gly Lys 
        


<210>  11
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:11, Mutant H3L amino acid sequence

<400>  11

Met Ala Ala Ala Lys Thr Pro Val Ile Val Val Pro Val Ala Ala Ala 
1               5                   10                  15      


Leu Pro Ser Glu Thr Phe Pro Asn Val His Glu His Ile Asn Asp Gln 
            20                  25                  30          


Lys Phe Asp Asp Val Ala Asp Asn Glu Val Met Ala Ala Lys Arg Asn 
        35                  40                  45              


Val Val Val Ala Lys Asp Asp Pro Asp His Tyr Lys Asp Tyr Ala Phe 
    50                  55                  60                  


Ile Gln Trp Thr Gly Gly Asn Ile Arg Asn Asp Asp Lys Tyr Thr His 
65                  70                  75                  80  


Phe Phe Ser Gly Phe Cys Asn Thr Met Cys Thr Glu Glu Thr Lys Arg 
                85                  90                  95      


Asn Ile Ala Arg His Leu Ala Leu Trp Asp Ser Asn Phe Phe Thr Glu 
            100                 105                 110         


Leu Glu Asn Lys Lys Val Glu Tyr Val Val Ile Val Glu Asn Asp Asn 
        115                 120                 125             


Val Ile Ala Ala Ile Ala Phe Leu Ala Pro Val Leu Lys Ala Met His 
    130                 135                 140                 


Asp Lys Lys Ile Asp Ile Leu Gln Met Ala Glu Ala Ile Thr Gly Asn 
145                 150                 155                 160 


Lys Val Lys Thr Glu Leu Val Ala Asp Lys Asn His Ala Ile Phe Thr 
                165                 170                 175     


Tyr Thr Gly Gly Tyr Asp Val Ser Leu Ser Ala Tyr Ile Ile Arg Val 
            180                 185                 190         


Thr Thr Ala Leu Asn Ile Ala Asp Glu Ile Ile Lys Ser Gly Gly Leu 
        195                 200                 205             


Ser Ser Gly Phe Tyr Phe Glu Ile Ala Arg Ile Glu Asn Glu Met Lys 
    210                 215                 220                 


Ile Asn Arg Gln Ile Leu Asp Asn Ala Ala Lys Tyr Val Glu His Asp 
225                 230                 235                 240 


Pro Arg Leu Val Ala Glu His Arg Phe Ala Asn Met Ala Ala Ala Ala 
                245                 250                 255     


Trp Ser Arg Ile Gly Thr Ala Ala Thr Lys Arg Tyr Pro Gly Val Met 
            260                 265                 270         


Tyr Ala Phe Thr Thr Pro Leu Ile Ser Phe Phe Gly Leu Phe Asp Ile 
        275                 280                 285             


Asn Val Ile Gly Leu Ile Val Ile Leu Phe Ile Met Phe Met Leu Ile 
    290                 295                 300                 


Phe Asn Val Lys Ser Lys Leu Leu Trp Phe Leu Thr Gly Thr Phe Val 
305                 310                 315                 320 


Thr Ala Phe Ile 
                


<210>  12
<211>  2548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:12,  Nucleotide sequences for mutated H3L gene

<400>  12
gaagaactca tagatcacga acatgtgcaa tacaaaataa attgttacaa tattctaaga       60

tatcatttat tgccagacag tgacgtgttt gtatatttta gtaattcatt aaacagagaa      120

gcattggaat acgcatttta tatctttttg tcgaaatatg taaatgtgaa acaatggata      180

gacgaaaata taactcgtat taaagagttg tatatgatta atttcaataa ctaaatggcg      240

gcggcgaaaa ctcctgttat tttaatttat tatgatattt aaatatcgcc taatatggcg      300

gcggcgaaaa ctcctgttat tgttgtgcca gttgctgctg cacttccatc agaaacattt      360

cctaatgttc atgagcatat taatgatcag aagttcgatg atgtagcgga caacgaagtt      420

atggcagcaa aaagaaatgt tgtggtagcc aaggatgatc cagatcatta caaggattat      480

gcgtttatac agtggactgg aggaaacatt agaaatgatg acaagtatac tcacttcttt      540

tcagggtttt gtaacactat gtgtacagag gaaacgaaaa gaaatatcgc tagacattta      600

gccctatggg attctaattt ttttaccgag ttagaaaata aaaaggtaga atatgtagtt      660

attgtagaaa acgataacgt tattgcggct attgcgtttc ttgctcccgt cttgaaggca      720

atgcatgaca aaaaaataga tatcctacag atggcagaag ctattacagg caataaagtt      780

aaaaccgagc ttgtagcgga caaaaatcat gccatattca catatacagg agggtatgat      840

gttagcttat cagcctatat tattagagtt actacggcgc tgaacatcgc agatgaaatt      900

ataaagtctg gaggtctatc atcgggattt tattttgaaa tagccagaat tgaaaacgaa      960

atgaagatca ataggcagat actggataat gccgccaaat atgtagaaca cgatccccga     1020

cttgttgcag aacaccgttt cgcaaacatg gcagcggctg cttggtctag aataggaacg     1080

gcagctacta aacgttatcc aggagttatg tacgcgttta ctactccact gatttcattt     1140

tttggattgt ttgatattaa tgttataggt ttgattgtaa ttttgtttat tatgtttatg     1200

ctcatcttta acgttaaatc taaactgtta tggttcctta caggaacatt cgttaccgca     1260

tttatctaat aatccaaacc cacccgcttt ttatagtaag tttttcaccc ataaataata     1320

aatacaataa ttaatttctc gtaaaagtag aaaatatatt ctaatttatt gcacggtaag     1380

gaagtagatc ataactcgag ataacttcgt ataatgtatg ctatacgaag ttattactag     1440

cgctaccggt cgccaatggt gagcaagggc gaggagctgt tcaccggggt ggtgcccatc     1500

ctggtcgagc tggacggcga cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag     1560

ggcgatgcca cctacggcaa gctgaccctg aagttcatct gcaccaccgg caagctgccc     1620

gtgccctggc ccaccctcgt gaccaccctg acctacggcg tgcagtgctt cagccgctac     1680

cccgaccaca tgaagcagca cgacttcttc aagtccgcca tgcccgaagg ctacgtccag     1740

gagcgcacca tcttcttcaa ggacgacggc aactacaaga cccgcgccga ggtgaagttc     1800

gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc     1860

aacatcctgg ggcacaagct ggagtacaac tacaacagcc acaacgtcta tatcatggcc     1920

gacaagcaga agaacggcat caaggtgaac ttcaagatcc gccacaacat cgaggacggc     1980

agcgtgcagc tcgccgacca ctaccagcag aacaccccca tcggcgacgg ccccgtgctg     2040

ctgcccgaca accactacct gagcacccag tccgccctga gcaaagaccc caacgagaag     2100

cgcgatcaca tggtcctgct ggagttcgtg accgccgccg ggatcactct cggcatggac     2160

gagctgtaca agtaacttac tagcgctcaa taacttcgta taatgtatgc tatacgaagt     2220

tattaataca ggaacattcg ttaccgcatt tatctaacac tattccatat tactaaaatc     2280

ggaacaccaa tgcggtgaca taaaataacc gctataacct aattcattta acatctcatt     2340

accacaagta ataacattat tagacttgtg ttttatcaaa tactgacaaa attgttgagc     2400

agatggatcg acctttgccg cctttttaac catccacgcg tctccagtac ctcgcctaat     2460

agcttgcggc agatatgttt tcttatccaa tcgcatagct ataaaatagg cgccgaaatc     2520

cacacatttg aattcgaata tatcatcc                                        2548


<210>  13
<211>  2467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:13,  Nucleotide sequences for mutated D8L gene

<400>  13
agaatctgaa ttttgttgag ataatatcgc ctggaacgcg aatgaagttc ttctagctcc       60

tattaacgga tatccgtcac ttgttataca cgcagcaaac acgtgcgtgt cttttgatct      120

tggaatatct tttattcgtt taatagatat taattctcta ggagtttcaa atatcacttc      180

ctcatccatt gtaattccca tactaagagc tatttttaaa cagttatcat ttcattttta      240

ctatgccgca acaactatct cctattaaat agaaactatt aatttattat gatatttaaa      300

tatcgcctaa tatgccgcaa caactatctc ctattaatat agaaactaaa aaagcaattt      360

ctaacgcgcg attgaagccg ttagacatac attataatga gtcgaaacca accactatcc      420

agaacactgg agcactagta gcgattaatt ttgcaggagg atatataagt ggagggtttc      480

tccccaatga atatgtgtta tcatcactac atatatattg gggaaaggaa gacgattatg      540

gatccaatca cttgatagat gtgtacaaat actctggaga gattaatctt gttcattgga      600

atgcgaaaaa atatagttct tatgaagagg cagcaaaaca cgatgatgga cttatcatta      660

tttctatatt cttacaagta ttggatcata aaaatgtata ttttcaaaag atagttaatc      720

aattggattc cattagatcc gccaatacgt ctgcaccgtt tgattcagta ttttatctag      780

acaatttgct gcctagtaag ttggattatt ttacatatct aggaacaact atcaaccact      840

ctgcagacgc tgtatggata atttttccaa cgccaataaa cattcattct gatcaactat      900

ctaaattcag aacactattg tcgtcgtcta atcatgatgg aaaaccgcat tatataacag      960

agaactatgc aaatccgtat aaattgaacg acgacacgca agtatattat tctggggaga     1020

ttatacgagc agcaactacc tctccagcgc gcgagaacta ttttatgaga tggttgtccg     1080

atttgagaga gacatgtttt tcatattatc aaaaatatat cgaagagaat aaaacattcg     1140

caattattgc catagtattc gtgtttatac ttaccgctat tctctttttt atgagtcgac     1200

gatattcgcg agaaaaacaa aactagtaat ccaaacccac ccgcttttta tagtaagttt     1260

ttcacccata aataataaat acaataatta atttctcgta aaagtagaaa atatattcta     1320

atttattgca cggtaaggaa gtagatcata actcgagata acttcgtata atgtatgcta     1380

tacgaagtta ttactagcgc taccggtcgc caatggtgag caagggcgag gagctgttca     1440

ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg     1500

tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca     1560

ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc     1620

agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc     1680

ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc     1740

gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg     1800

acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca     1860

acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc     1920

acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg     1980

gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca     2040

aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga     2100

tcactctcgg catggacgag ctgtacaagt aacttactag cgctcaataa cttcgtataa     2160

tgtatgctat acgaagttat taaatagtat tcgtgtttat acttaccgct attctctttt     2220

ttatgagtcg acgatattcg cgagaaaaac aaaactagat tcgatacctt gttgagcctc     2280

cattagaacg gcagtgactt cgctgccatt gtcatacgca ttaccatttc gaaaaaagca     2340

gtactttgaa tcgctaaatg atacagtacc cgaatctcta cttagtttac agattaaatc     2400

tccacattga atagttacat ttgattcatc ttcgatgttt aatgttcctc tgactatatc     2460

cccaacg                                                               2467


<210>  14
<211>  1897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:14,  Nucleotide sequences for mutated A27L gene

<400>  14
aaaagtggag atgtgtggtt tatccaggaa acggttttgt atccgcttcc atatttggat       60

ttcaggcaga agttggaccc aataatacta gatccattag aaaatttaac acgatgcaac      120

aatgtataga ctttacattt tctgatgtta ttaacatcga tatttataat ccatgtgttg      180

taccaaatat aaataacgca gagtgtcagt ttctaaaatc tgtactttaa atggacggaa      240

ctcttttccc cggagatgac ttaatatttt gttaattaaa attatattta taaaatatta      300

tataataaat ggacggaact cttttccccg gagatgacga tcttgcaatt ccagcaactg      360

aatttttttc tacaaaggct gctaaagcgc cagaggataa agccgcagac gctgctgcag      420

ccgctgcaga cgacaatgag gaaactctca aacaacggct aactaatttg gaaaaaaaga      480

ttactaatgt aacaacaaag tttgaacaaa tagaaaagtg ttgtaaacgc aacgatgaag      540

ttctatttag gttggaaaat cacgctgaaa ctctaagagc ggctatgata tctctggcta      600

aaaagattga tgttcagact ggacgggccg cagctgagta ataatccaaa cccacccgct      660

ttttatagta agtttttcac ccataaataa taaatacaat aattaatttc tcgtaaaagt      720

agaaaatata ttctaattta ttgcacggta aggaagtaga tcataactcg agataacttc      780

gtataatgta tgctatacga agttattact agcgctaccg gtcgccaatg gtgagcaagg      840

gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg      900

gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc      960

tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc     1020

tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct     1080

tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg     1140

gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg     1200

agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca     1260

actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga     1320

acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc     1380

agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc     1440

agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg     1500

tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaatag actagcgctc     1560

aataacttcg tataatgtat gctatacgaa gttatgttca gactggacgg cgcccatatg     1620

agtaataact taactctttt gttaattaaa agtatattca aaaaatgagt tatataaatg     1680

gcgaacatta taaatttatg gaacggaatt gtaccaacgg ttcaagatgt taatgttgcg     1740

agcattactg cgtttaaatc tatgatagat gaaacatggg ataaaaaaat cgaagcaaat     1800

acatgcatca gtagaaaaca tagaaacatt attcacgaag ttattaggga ctttatgaaa     1860

gcctatccta aaatggatga gaataaaaaa tctccat                              1897


<210>  15
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:15,  Nucleotide sequences for mutated L1R gene

<400>  15
aatattgtac gatgtaatac tagcgtgaac aacttacaga tggataaaac ttcctcatta       60

agattgtcat gtggattaag caatagtgat agattttcta ctgttcccgt caatagagca      120

aaagtagttc aacataatat taaacactcg ttcgacctaa aattgcattt gatcagttta      180

ttatctctct tggtaatatg gatactaatt gtagctattt aaatgggtgc cgcggcaagc      240

ttaatatttt gttaattaaa attatattta taaaatatta tataataaat gggtgccgcg      300

gcaagcatac agacgacggt gaatacactc agcgaacgta tctcgtctaa attagaacaa      360

gcagcggctg ctagtgctgc agcagcatgt gctatagaaa tcggaaattt ttatatccga      420

caaaaccatg gatgtaacct cactgttaaa aatatgtgcg ctgcggccgc ggctgctcag      480

ttggatgctg tgttatcagc cgctacagaa acatatagtg gattaacacc ggaacaaaaa      540

gcatacgtgc cagctatgtt tactgctgcg ttaaacattc agacgagtgt aaacactgtt      600

gttagagatt ttgaaaatta tgtgaaacag acttgtaatt ctagcgcggt cgtcgataac      660

gcattagcga tacaaaacgt aatcatagat gaatgttacg gagccccagg atctccaaca      720

aatttggaat ttattaatac aggatctagc aaaggaaatt gtgccattaa ggcgttgatg      780

caattgacga ctaaggccac tactcaaata gcacctaaac aagttgctgg tacaggagtt      840

cagttttata tgattgttat cggtgttata atattggcag cgttgtttat gtactatgcc      900

aagcgtatgt tgttcacatc caccaatgat aaaatcaaac ttattttagc caataaggaa      960

aacgtccatt ggactactta catggacaca ttctttagaa cttctccgat ggttattgct     1020

accacggata tgcaaaactg ataatccaaa cccacccgct ttttatagta agtttttcac     1080

ccataaataa taaatacaat aattaatttc tcgtaaaagt agaaaatata ttctaattta     1140

ttgcacggta aggaagtaga tcataactcg agataacttc gtataatgta tgctatacga     1200

agttattagc gctaccggtc gccaatggtg agcaagggcg aggagctgtt caccggggtg     1260

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc     1320

gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc     1380

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc     1440

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc     1500

tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag     1560

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag     1620

gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat     1680

atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc     1740

gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc     1800

cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc     1860

aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc     1920

ggcatggacg agctgtacaa gtaattgact agcgctcaat aacttcgtat aatgtatgct     1980

atacgaagtt atattgctac cacggatatg caaaactgaa aatatattga taatatttta     2040

atagattaac atggaagtta tcactgatcg tctagacgat atagtgaaac aaaatatagc     2100

ggatgaaaaa tttgtagatt ttgttataca cggtctagag catcaatgtc ctgctatact     2160

tcgaccatta attaggttgt ttattgatat actattattt gttatagtaa tttatatttt     2220

tacggtacgt ctagtaagta gaaa                                            2244


<210>  16
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:16,  Nucleotide sequences for CD55-A27

<400>  16
atggattgtg gactgccccc cgacgtccct aacgctcaac ccgctctgga aggcagaaca       60

tccttccccg aagacaccgt gatcacctac aagtgtgagg agagcttcgt caagatcccc      120

ggcgagaagg atagcgtcat ctgtctgaag ggaagccaat ggtccgacat cgaagagttc      180

tgcaacagaa gctgtgaggt gcctaccaga ctgaacagcg cttctctgaa gcagccttac      240

atcacccaga actacttccc cgtgggcacc gtggtggagt acgagtgcag acccggatac      300

agaagagagc cttctctgag ccccaagctg acatgcctcc agaacctcaa gtggagcacc      360

gctgtggagt tttgcaagaa gaagagctgc cccaatcccg gcgagattag aaacggccag      420

attgacgtgc ccggcggcat tctgtttggc gccaccatca gcttcagctg caacaccggc      480

tacaagctgt ttggaagcac cagctccttc tgtctgatca gcggctccag cgtccagtgg      540

agcgatcctc tgcccgagtg tagggagatc tactgccccg cccctcctca aatcgacaac      600

ggcattatcc aaggcgagag ggatcactac ggctatagac agagcgtcac ctacgcttgc      660

aacaagggat tcaccatgat cggcgagcac tccatctact gcacagtcaa caacgacgag      720

ggagaatgga gcggccctcc tcccgagtgt aggggcggcg gcggcagcgg cggcggcggc      780

agcggcggcg gcggcagcga cggaactctt ttccccggag atgacgatct tgcaattcca      840

gcaactgaat ttttttctac aaaggctgct aaagcgccag aggataaagc cgcagacgct      900

gctgcagccg ctgcagacga caatgaggaa actctcaaac aacggctaac taatttggaa      960

aaaaagatta ctaatgtaac aacaaagttt gaacaaatag aaaagtgttg taaacgcaac     1020

gatgaagttc tatttaggtt ggaaaatcac gctgaaactc taagagcggc tatgatatct     1080

ctggctaaaa agattgatgt tcagactgga cgggccgcag ctgagtaata a              1131


<210>  17
<211>  1581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:17,  Nucleotide sequences for FAP-CD3

<400>  17
atggactgga tctggcgcat cctcttcctc gtcggcgctg ctaccggcgc tcattctcag       60

gtgcagctga agcagtctgg agctgaactg gtgaaacccg gggcatcagt gaagctgtcc      120

tgcaagactt ctggctacac cttcactgaa aatattatac actgggtaaa gcagaggtct      180

gggcagggtc ttgagtggat tgggtggttt caccctggaa gtggtagtat aaagtacaat      240

gagaaattca aggacaaggc cacattgact gcggacaaat cctccagcac agtctatatg      300

gagcttagta gattgacatc tgaagactct gcggtctatt tctgtgcaag acacggagga      360

actgggcgag gagctatgga ctactggggt caaggaacct cagtcaccgt ctcgagtggt      420

ggaggcggtt caggcggagg tggctctggc ggtagtgcac aaattctgat gacccagtct      480

cctgcttcct cagttgtatc tctggggcag agggccacca tctcatgcag ggccagcaaa      540

agtgtcagta catctgccta tagttatatg cactggtacc aacagaaacc aggacagcca      600

cccaaactcc tcatctatct tgcatccaac ctagaatctg gggtccctcc caggttcagt      660

ggcagtgggt ctgggacaga cttcaccctc aacatccacc ctgtggagga ggaggatgct      720

gcaacctatt actgtcagca cagtagggag cttccgtaca cgttcggagg ggggaccaag      780

ctggaaataa aacgggcggg atccggagga ggaggatctg gaggaggagg aagtggcggg      840

ggaggctcag tcgacgatat caagctgcag cagtctggag cagagctggc tagaccagga      900

gcatcagtga aaatgagctg taagacctcc ggctatacat tcactcgcta cacaatgcac      960

tgggtgaagc agcgacctgg gcagggactg gaatggatcg ggtacattaa tccaagcagg     1020

ggatacacca actacaacca gaagtttaaa gacaaggcta ctctgactac cgataagtca     1080

agctccaccg catacatgca gctgtctagt ctgacatcag aggacagcgc cgtgtactat     1140

tgcgctcgct actatgacga tcattattgt ctggattatt ggggacaggg gacaactctg     1200

acagtgtcaa gcggaggagg aggaagcgga ggaggcggct ccggcggagg aggctctgac     1260

atccagctga ctcagtctcc cgccattatg tcagcttccc ctggcgaaaa agtgaccatg     1320

acatgccggg cctcctctag tgtcagctat atgaactggt accagcagaa atccgggact     1380

tctccaaagc gatggatcta tgacacctct aaggtggcta gtggagtccc ctaccggttc     1440

tccggatctg gcagtgggac ttcatatagc ctgaccattt caagcatgga ggccgaagat     1500

gctgcaacct actattgtca gcagtggtcc tctaatcccc tgaccttcgg ggctgggact     1560

aaactggaac tgaaatcatg a                                               1581


<210>  18
<211>  1559
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:18,  Nucleotide sequences for BCMA-CD3 scFv

<400>  18
atgctataaa tggctctgcc cgtgacagct ctgctgctcc ctctggctct gctgctgcat       60

gctgctaggc ccgacatcgt gctgacccag tcccctccta gcctcgccat gtctctggga      120

aagagagcca ccatcagctg tagagcctcc gaaagcgtga ccattctcgg cagccatctg      180

atccactggt atcagcagaa gcccggccaa ccccctacac tgctgatcca gctggccagc      240

aatgtgcaga ccggagtgcc cgctagattt tccggatccg gatccagaac cgactttaca      300

ctgaccatcg accccgtgga agaggacgac gtggccgtgt actactgtct gcagtctaga      360

accatcccca gaacattcgg cggaggcaca aagctggaga tcaagggctc cacaagcggc      420

agcggcaaac ccggcagcgg agagggcagc acaaagggcc aaatccagct ggtgcagagc      480

ggccccgaac tcaagaagcc cggagaaacc gtgaagatca gctgcaaggc ctccggctac      540

acattcaccg attactccat caattgggtc aagagggccc ccggcaaggg actgaagtgg      600

atgggctgga ttaataccga gacaagagag cccgcctacg cttacgactt tagaggaagg      660

ttcgccttca gcctcgagac atccgctagc accgcctatc tgcagatcaa caacctcaat      720

acgaggacac cgccacctat ttctgtgctc tggactactc ctatgccatg gattactggg      780

gacaaggcac aagcgtcaca gtgagctccg gaggaggagg atccgtcgac gacatcaagc      840

tccagcagtc cggcgccgaa ctcgctagac ccggagcttc cgtcaagatg agctgcaaga      900

cctccggata cacattcaca agatacacaa tgcactgggt caaacaaagg cccggccaag      960

gcctcgagtg gattggctac atcaacccct ctagaggata taccaactac aatcagaaat     1020

tcaaggacaa agccaccctc acaaccgaca agagcagcag cacagcctac atgcagctga     1080

gctctctgac atccgaagac agcgccgtgt attactgcgc tagatactat gacgaccact     1140

actgtctgga ctattgggga caaggaacaa cactgacagt cagctccggc ggcggaggat     1200

ccggaggcgg aggaagcggc ggaggaggca gcgacatcca gctgacacag tcccccgcca     1260

ttatgagcgc ctcccccggc gaaaaggtca ccatgacatg cagagcctcc agctccgtca     1320

gctatatgaa ctggtaccag cagaaaagcg gcacaagccc taagaggtgg atctacgaca     1380

cctccaaggt cgcttccgga gtgccctata ggttctccgg aagcggatcc ggaacctcct     1440

actctctgac aatctcctcc atggaagccg aggacgctgc cacctattac tgccagcagt     1500

ggagcagcaa tcctctcacc tttggcgccg gaaccaaact cgagctgaag tcctaatga      1559


<210>  19
<211>  1212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:19,  Nucleotide sequences for PD-1-ED-hIgG1-Fc

<400>  19
atgcaaattc cccaagctcc ttggcccgtg gtctgggccg tgctgcagct gggatggaga       60

cccggctggt ttctcgactc ccccgatagg ccttggaacc cccctacctt ttttcccgct      120

ctgctggtgg tgaccgaagg cgacaacgcc accttcacat gcagcttcag caacaccagc      180

gagagcttcg tgctcaactg gtatagaatg tcccctagca accagaccga caagctggcc      240

gccttccccg aggatagatc ccaacccggc caagactgca gattcagagt gacccagctg      300

cccaacggaa gggatttcca catgtccgtg gtcagagcta gaaggaatga cagcggaaca      360

tacctctgcg gcgccatttc tctggcccct aaggctcaga tcaaggagtc tctgagggct      420

gaactgagag tgacagagag aagagccgaa gtgcccacag cccacccttc ccctagccct      480

agacccgctg gccaatttca gacactcgtc gagcccaaga gctgcgataa gacccacaca      540

tgccctcctt gtcccgctcc cgagctgctc ggcggaccct ccgtgtttct gtttcccccc      600

aaacccaagg acaccctcat gatttctaga acacccgagg tgacatgcgt ggtggtggat      660

gtgtcccatg aagaccccga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      720

aacgctaaga ccaagcctag agaggaacag tataacagca cctatagagt cgtgtccgtg      780

ctgacagtgc tgcaccaaga ctggctgaac ggcaaagagt ataaatgcaa ggtcagcaac      840

aaggctctgc ccgcccccat tgagaagacc atcagcaagg ccaagggcca gcctagggaa      900

cctcaagtgt ataccctccc tccctctaga gaggagatga ccaagaatca agtgtccctc      960

acatgcctcg tgaaaggctt ctaccctagc gacatcgccg tcgaatggga aagcaacgga     1020

cagcccgaga acaactacaa gaccacaccc cccgtgctcg attccgacgg cagcttcttt     1080

ctgtactcca agctgaccgt ggataagtct agatggcaac aaggcaatgt gttcagctgc     1140

tccgtcatgc acgaggctct gcacaaccac tacacccaga aatctctgtc tctgagcccc     1200

ggcaaatgat ga                                                         1212


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 1 of the Peptide Array

<400>  20

Met Ala Ala Ala Lys Thr Pro Val Ile Val Val Pro 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 2 of the Peptide Array

<400>  21

Lys Thr Pro Val Ile Val Val Pro Val Ile Asp Arg 
1               5                   10          


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 3 of the Peptide Array

<400>  22

Ile Val Val Pro Val Ile Asp Arg Leu Pro Ser Glu 
1               5                   10          


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 4 of the Peptide Array

<400>  23

Val Ile Asp Arg Leu Pro Ser Glu Thr Phe Pro Asn 
1               5                   10          


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 5 of the Peptide Array

<400>  24

Leu Pro Ser Glu Thr Phe Pro Asn Val His Glu His 
1               5                   10          


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 6 of the Peptide Array

<400>  25

Thr Phe Pro Asn Val His Glu His Ile Asn Asp Gln 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 7 of the Peptide Array

<400>  26

Val His Glu His Ile Asn Asp Gln Lys Phe Asp Asp 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 8 of the Peptide Array

<400>  27

Ile Asn Asp Gln Lys Phe Asp Asp Val Lys Asp Asn 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 9 of the Peptide Array

<400>  28

Lys Phe Asp Asp Val Lys Asp Asn Glu Val Met Pro 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 10 of the Peptide Array

<400>  29

Val Lys Asp Asn Glu Val Met Pro Glu Lys Arg Asn 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 11 of the Peptide Array

<400>  30

Glu Val Met Pro Glu Lys Arg Asn Val Val Val Val 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 12 of the Peptide Array

<400>  31

Glu Lys Arg Asn Val Val Val Val Lys Asp Asp Pro 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 13 of the Peptide Array

<400>  32

Val Val Val Val Lys Asp Asp Pro Asp His Tyr Lys 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 14 of the Peptide Array

<400>  33

Lys Asp Asp Pro Asp His Tyr Lys Asp Tyr Ala Phe 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 15 of the Peptide Array

<400>  34

Asp His Tyr Lys Asp Tyr Ala Phe Ile Gln Trp Thr 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 16 of the Peptide Array

<400>  35

Asp Tyr Ala Phe Ile Gln Trp Thr Gly Gly Asn Ile 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 17 of the Peptide Array

<400>  36

Ile Gln Trp Thr Gly Gly Asn Ile Arg Asn Asp Asp 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 18 of the Peptide Array

<400>  37

Gly Gly Asn Ile Arg Asn Asp Asp Lys Tyr Thr His 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 19 of the Peptide Array

<400>  38

Arg Asn Asp Asp Lys Tyr Thr His Phe Phe Ser Gly 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 20 of the Peptide Array

<400>  39

Lys Tyr Thr His Phe Phe Ser Gly Phe Cys Asn Thr 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 21 of the Peptide Array

<400>  40

Phe Phe Ser Gly Phe Cys Asn Thr Met Cys Thr Glu 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 22 of the Peptide Array

<400>  41

Phe Cys Asn Thr Met Cys Thr Glu Glu Thr Lys Arg 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 23 of the Peptide Array

<400>  42

Met Cys Thr Glu Glu Thr Lys Arg Asn Ile Ala Arg 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 24 of the Peptide Array

<400>  43

Glu Thr Lys Arg Asn Ile Ala Arg His Leu Ala Leu 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 25 of the Peptide Array

<400>  44

Asn Ile Ala Arg His Leu Ala Leu Trp Asp Ser Asn 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 26 of the Peptide Array

<400>  45

His Leu Ala Leu Trp Asp Ser Asn Phe Phe Thr Glu 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 27 of the Peptide Array

<400>  46

Trp Asp Ser Asn Phe Phe Thr Glu Leu Glu Asn Lys 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 28 of the Peptide Array

<400>  47

Phe Phe Thr Glu Leu Glu Asn Lys Lys Val Glu Tyr 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 29 of the Peptide Array

<400>  48

Leu Glu Asn Lys Lys Val Glu Tyr Val Val Ile Val 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 30 of the Peptide Array

<400>  49

Lys Val Glu Tyr Val Val Ile Val Glu Asn Asp Asn 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 31 of the Peptide Array

<400>  50

Val Val Ile Val Glu Asn Asp Asn Val Ile Glu Asp 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 32 of the Peptide Array

<400>  51

Glu Asn Asp Asn Val Ile Glu Asp Ile Thr Phe Leu 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 33 of the Peptide Array

<400>  52

Val Ile Glu Asp Ile Thr Phe Leu Arg Pro Val Leu 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 34 of the Peptide Array

<400>  53

Ile Thr Phe Leu Arg Pro Val Leu Lys Ala Met His 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 35 of the Peptide Array

<400>  54

Arg Pro Val Leu Lys Ala Met His Asp Lys Lys Ile 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 36 of the Peptide Array

<400>  55

Lys Ala Met His Asp Lys Lys Ile Asp Ile Leu Gln 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 37 of the Peptide Array

<400>  56

Asp Lys Lys Ile Asp Ile Leu Gln Met Arg Glu Ile 
1               5                   10          


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 38 of the Peptide Array

<400>  57

Asp Ile Leu Gln Met Arg Glu Ile Ile Thr Gly Asn 
1               5                   10          


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 39 of the Peptide Array

<400>  58

Met Arg Glu Ile Ile Thr Gly Asn Lys Val Lys Thr 
1               5                   10          


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 40 of the Peptide Array

<400>  59

Ile Thr Gly Asn Lys Val Lys Thr Glu Leu Val Met 
1               5                   10          


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 41 of the Peptide Array

<400>  60

Lys Val Lys Thr Glu Leu Val Met Asp Lys Asn His 
1               5                   10          


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 42 of the Peptide Array

<400>  61

Glu Leu Val Met Asp Lys Asn His Ala Ile Phe Thr 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 43 of the Peptide Array

<400>  62

Asp Lys Asn His Ala Ile Phe Thr Tyr Thr Gly Gly 
1               5                   10          


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 44 of the Peptide Array

<400>  63

Ala Ile Phe Thr Tyr Thr Gly Gly Tyr Asp Val Ser 
1               5                   10          


<210>  64
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 45 of the Peptide Array

<400>  64

Tyr Thr Gly Gly Tyr Asp Val Ser Leu Ser Ala Tyr 
1               5                   10          


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 46 of the Peptide Array

<400>  65

Tyr Asp Val Ser Leu Ser Ala Tyr Ile Ile Arg Val 
1               5                   10          


<210>  66
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 47 of the Peptide Array

<400>  66

Leu Ser Ala Tyr Ile Ile Arg Val Thr Thr Glu Leu 
1               5                   10          


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 48 of the Peptide Array

<400>  67

Ile Ile Arg Val Thr Thr Glu Leu Asn Ile Val Asp 
1               5                   10          


<210>  68
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 49 of the Peptide Array

<400>  68

Thr Thr Glu Leu Asn Ile Val Asp Glu Ile Ile Lys 
1               5                   10          


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 50 of the Peptide Array

<400>  69

Asn Ile Val Asp Glu Ile Ile Lys Ser Gly Gly Leu 
1               5                   10          


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 51 of the Peptide Array

<400>  70

Glu Ile Ile Lys Ser Gly Gly Leu Ser Ser Gly Phe 
1               5                   10          


<210>  71
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 52 of the Peptide Array

<400>  71

Ser Gly Gly Leu Ser Ser Gly Phe Tyr Phe Glu Ile 
1               5                   10          


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 53 of the Peptide Array

<400>  72

Ser Ser Gly Phe Tyr Phe Glu Ile Ala Arg Ile Glu 
1               5                   10          


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 54 of the Peptide Array

<400>  73

Tyr Phe Glu Ile Ala Arg Ile Glu Asn Glu Met Lys 
1               5                   10          


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 55 of the Peptide Array

<400>  74

Ala Arg Ile Glu Asn Glu Met Lys Ile Asn Arg Gln 
1               5                   10          


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 56 of the Peptide Array

<400>  75

Asn Glu Met Lys Ile Asn Arg Gln Ile Leu Asp Asn 
1               5                   10          


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 57 of the Peptide Array

<400>  76

Ile Asn Arg Gln Ile Leu Asp Asn Ala Ala Lys Tyr 
1               5                   10          


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 58 of the Peptide Array

<400>  77

Ile Leu Asp Asn Ala Ala Lys Tyr Val Glu His Asp 
1               5                   10          


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 59 of the Peptide Array

<400>  78

Ala Ala Lys Tyr Val Glu His Asp Pro Arg Leu Val 
1               5                   10          


<210>  79
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 60 of the Peptide Array

<400>  79

Val Glu His Asp Pro Arg Leu Val Ala Glu His Arg 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 61 of the Peptide Array

<400>  80

Pro Arg Leu Val Ala Glu His Arg Phe Glu Asn Met 
1               5                   10          


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 62 of the Peptide Array

<400>  81

Ala Glu His Arg Phe Glu Asn Met Lys Pro Asn Phe 
1               5                   10          


<210>  82
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 63 of the Peptide Array

<400>  82

Phe Glu Asn Met Lys Pro Asn Phe Trp Ser Arg Ile 
1               5                   10          


<210>  83
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 64 of the Peptide Array

<400>  83

Lys Pro Asn Phe Trp Ser Arg Ile Gly Thr Ala Ala 
1               5                   10          


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 65 of the Peptide Array

<400>  84

Trp Ser Arg Ile Gly Thr Ala Ala Thr Lys Arg Tyr 
1               5                   10          


<210>  85
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 66 of the Peptide Array

<400>  85

Gly Thr Ala Ala Thr Lys Arg Tyr Pro Gly Val Met 
1               5                   10          


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 67 of the Peptide Array

<400>  86

Thr Lys Arg Tyr Pro Gly Val Met Tyr Ala Phe Thr 
1               5                   10          


<210>  87
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 68 of the Peptide Array

<400>  87

Pro Gly Val Met Tyr Ala Phe Thr Thr Pro Leu Ile 
1               5                   10          


<210>  88
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Position 69 of the Peptide Array

<400>  88

Tyr Ala Phe Thr Thr Pro Leu Ile Ser Phe Phe Gly 
1               5                   10          


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 11-18 of the H3L Peptides

<400>  89

Pro Val Ile Asp Arg Leu Pro 
1               5           


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 30-40 of the H3L Peptides

<400>  90

Asn Asp Gln Lys Phe Asp Asp Val Lys Asp Asn 
1               5                   10      


<210>  91
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 44-52 of the H3L Peptides

<400>  91

Pro Glu Arg Lys Asn Val Val Val Val 
1               5                   


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 128-137 of the H3L Peptides

<400>  92

Asn Val Ile Glu Asp Ile Thr Phe Leu Arg 
1               5                   10  


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 152-156 of the H3L Peptides

<400>  93

Gln Met Arg Glu Ile 
1               5   


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 161-168 of the H3L Peptides

<400>  94

Lys Val Lys Thr Glu Leu Val Met 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 197-204 of the H3L Peptides

<400>  95

Asn Ile Val Asp Glu Ile Ile Lys 
1               5               


<210>  96
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 224-229 of the H3L Peptides

<400>  96

Lys Ile Asn Arg Gln Ile 
1               5       


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 249-265 of the H3L Peptides

<400>  97

Phe Glu Asn Met Lys Pro Asn Phe 
1               5               


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 1 (Seq No. 89)

<400>  98

Ala Val Ile Asp Arg Leu Pro 
1               5           


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 1 (Seq No. 89)

<400>  99

Pro Ala Ile Asp Arg Leu Pro 
1               5           


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 1 (Seq No. 89)

<400>  100

Pro Val Ala Asp Arg Leu Pro 
1               5           


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 1 (Seq No. 89)

<400>  101

Pro Val Ile Ala Arg Leu Pro 
1               5           


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 1 (Seq No. 89)

<400>  102

Pro Val Ile Asp Ala Leu Pro 
1               5           


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 1 (Seq No. 89)

<400>  103

Pro Val Ile Asp Arg Ala Pro 
1               5           


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 1 (Seq No. 89)

<400>  104

Pro Val Ile Asp Arg Leu Ala 
1               5           


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 2 (Seq No. 90)

<400>  105

Ala Asp Gln Lys Phe Asp Asp Val Lys Asp Asn 
1               5                   10      


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 2 (Seq No. 90)

<400>  106

Asn Ala Gln Lys Phe Asp Asp Val Lys Asp Asn 
1               5                   10      


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 2 (Seq No. 90)

<400>  107

Asn Asp Ala Lys Phe Asp Asp Val Lys Asp Asn 
1               5                   10      


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 2 (Seq No .90)

<400>  108

Asn Asp Gln Ala Phe Asp Asp Val Lys Asp Asn 
1               5                   10      


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 2 (Seq No. 90)

<400>  109

Asn Asp Gln Lys Ala Asp Asp Val Lys Asp Asn 
1               5                   10      


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 2 (Seq No. 90)

<400>  110

Asn Asp Gln Lys Phe Ala Asp Val Lys Asp Asn 
1               5                   10      


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 2 (Seq No. 90)

<400>  111

Asn Asp Gln Lys Phe Asp Ala Val Lys Asp Asn 
1               5                   10      


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 2 (Seq No. 90)

<400>  112

Asn Asp Gln Lys Phe Asp Asp Ala Lys Asp Asn 
1               5                   10      


<210>  113
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 2 (Seq No. 90)

<400>  113

Asn Asp Gln Lys Phe Asp Asp Val Ala Asp Asn 
1               5                   10      


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 2 (Seq No. 90)

<400>  114

Asn Asp Gln Lys Phe Asp Asp Val Lys Ala Asn 
1               5                   10      


<210>  115
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 2 (Seq No. 90)

<400>  115

Asn Asp Gln Lys Phe Asp Asp Val Lys Asp Ala 
1               5                   10      


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 3 (Seq No. 91)

<400>  116

Ala Lys Arg Asn Val Val Val Val 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 3 (Seq No. 91)

<400>  117

Glu Ala Arg Asn Val Val Val Val 
1               5               


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 3 (Seq No. 91)

<400>  118

Glu Lys Ala Asn Val Val Val Val 
1               5               


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 3 (Seq No. 91)

<400>  119

Glu Lys Arg Ala Val Val Val Val 
1               5               


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 3 (Seq No. 91)

<400>  120

Glu Lys Arg Asn Ala Val Val Val 
1               5               


<210>  121
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 3 (Seq No. 91)

<400>  121

Glu Lys Arg Asn Val Ala Val Val 
1               5               


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 3 (Seq No. 91)

<400>  122

Glu Lys Arg Asn Val Val Ala Val 
1               5               


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 3 (Seq No. 91)

<400>  123

Glu Lys Arg Asn Val Val Val Ala 
1               5               


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 4 (Seq No. 92)

<400>  124

Ala Val Ile Glu Asp Ile Thr Phe Leu Arg 
1               5                   10  


<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 4 (Seq No. 92)

<400>  125

Asn Ala Ile Glu Asp Ile Thr Phe Leu Arg 
1               5                   10  


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 4 (Seq No. 92)

<400>  126

Asn Val Ala Glu Asp Ile Thr Phe Leu Arg 
1               5                   10  


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 4 (Seq No. 92)

<400>  127

Asn Val Ile Ala Asp Ile Thr Phe Leu Arg 
1               5                   10  


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 4 (Seq No. 92)

<400>  128

Asn Val Ile Glu Ala Ile Thr Phe Leu Arg 
1               5                   10  


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 4 (Seq No. 92)

<400>  129

Asn Val Ile Glu Asp Ala Thr Phe Leu Arg 
1               5                   10  


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 4 (Seq No. 92)

<400>  130

Asn Val Ile Glu Asp Ile Ala Phe Leu Arg 
1               5                   10  


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 4 (Seq No. 92)

<400>  131

Asn Val Ile Glu Asp Ile Thr Ala Leu Arg 
1               5                   10  


<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 4 (Seq No. 92)

<400>  132

Asn Val Ile Glu Asp Ile Thr Phe Ala Arg 
1               5                   10  


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 4 (Seq No. 92)

<400>  133

Asn Val Ile Glu Asp Ile Thr Phe Leu Ala 
1               5                   10  


<210>  134
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 5 (Seq No. 93)

<400>  134

Ala Met Arg Glu Ile 
1               5   


<210>  135
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 5 (Seq No. 93)

<400>  135

Gln Ala Arg Glu Ile 
1               5   


<210>  136
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 5 (Seq No. 93)

<400>  136

Gln Met Ala Glu Ile 
1               5   


<210>  137
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 5 (Seq No. 93)

<400>  137

Gln Met Arg Ala Ile 
1               5   


<210>  138
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 5 (Seq No. 93)

<400>  138

Gln Met Arg Glu Ala 
1               5   


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 6 (Seq No. 94)

<400>  139

Ala Val Lys Thr Glu Leu Val Met 
1               5               


<210>  140
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 6 (Seq No. 94)

<400>  140

Lys Ala Lys Thr Glu Leu Val Met 
1               5               


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 6 (Seq No. 94)

<400>  141

Lys Val Ala Thr Glu Leu Val Met 
1               5               


<210>  142
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 6 (Seq No. 94)

<400>  142

Lys Val Lys Ala Glu Leu Val Met 
1               5               


<210>  143
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 6 (Seq No. 94)

<400>  143

Lys Val Lys Thr Ala Leu Val Met 
1               5               


<210>  144
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 6 (Seq No. 94)

<400>  144

Lys Val Lys Thr Glu Ala Val Met 
1               5               


<210>  145
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 6 (Seq No. 94)

<400>  145

Lys Val Lys Thr Glu Leu Ala Met 
1               5               


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 6 (Seq No. 94)

<400>  146

Lys Val Lys Thr Glu Leu Val Ala 
1               5               


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 7 (Seq No. 95)

<400>  147

Ala Ile Val Asp Glu Ile Ile Lys 
1               5               


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 7 (Seq No. 95)

<400>  148

Asn Ala Val Asp Glu Ile Ile Lys 
1               5               


<210>  149
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 7 (Seq No. 95)

<400>  149

Asn Ile Ala Asp Glu Ile Ile Lys 
1               5               


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 7 (Seq No. 95)

<400>  150

Asn Ile Val Ala Glu Ile Ile Lys 
1               5               


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 7 (Seq No. 95)

<400>  151

Asn Ile Val Asp Ala Ile Ile Lys 
1               5               


<210>  152
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 7 (Seq No. 95)

<400>  152

Asn Ile Val Asp Glu Ala Ile Lys 
1               5               


<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 7 (Seq No. 95)

<400>  153

Asn Ile Val Asp Glu Ile Ala Lys 
1               5               


<210>  154
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 7 (Seq No. 95)

<400>  154

Asn Ile Val Asp Glu Ile Ile Ala 
1               5               


<210>  155
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 8 (Seq No. 96)

<400>  155

Ala Ile Asn Arg Gln Ile 
1               5       


<210>  156
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 8 (Seq No. 96)

<400>  156

Lys Ala Asn Arg Gln Ile 
1               5       


<210>  157
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 8 (Seq No. 96)

<400>  157

Lys Ile Ala Arg Gln Ile 
1               5       


<210>  158
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 8 (Seq No. 96)

<400>  158

Lys Ile Asn Ala Gln Ile 
1               5       


<210>  159
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 8 (Seq No. 96)

<400>  159

Lys Ile Asn Arg Ala Ile 
1               5       


<210>  160
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 8 (Seq No. 96)

<400>  160

Lys Ile Asn Arg Gln Ala 
1               5       


<210>  161
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 9 (Seq No. 97)

<400>  161

Ala Glu Asn Met Lys Pro Asn Phe 
1               5               


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 9 (Seq No. 97)

<400>  162

Phe Ala Asn Met Lys Pro Asn Phe 
1               5               


<210>  163
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 9 (Seq No. 97)

<400>  163

Phe Glu Ala Met Lys Pro Asn Phe 
1               5               


<210>  164
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 9 (Seq No. 97)

<400>  164

Phe Glu Asn Ala Lys Pro Asn Phe 
1               5               


<210>  165
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 9 (Seq No. 97)

<400>  165

Phe Glu Asn Met Ala Pro Asn Phe 
1               5               


<210>  166
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 9 (Seq No. 97)

<400>  166

Phe Glu Asn Met Lys Ala Asn Phe 
1               5               


<210>  167
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 9 (Seq No. 97)

<400>  167

Phe Glu Asn Met Lys Pro Ala Phe 
1               5               


<210>  168
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Peptide 9 (Seq No. 97)

<400>  168

Phe Glu Asn Met Lys Pro Asn Ala 
1               5               


<210>  169
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control peptide for set 3 peptides

<400>  169

Glu Lys Arg Asn Val Val Val Val 
1               5               


<210>  170
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant H3L amino acid

<400>  170

Met Ala Ala Ala Lys Thr Pro Val Ile Val Val Pro Val Ala Ala Ala 
1               5                   10                  15      


Leu Pro Ser Glu Thr Phe Pro Asn Val His Glu His Ile Asn Asp Gln 
            20                  25                  30          


Ala Ala Ala Asp Val Ala Asp Ala Glu Val Met Ala Ala Lys Arg Asn 
        35                  40                  45              


Val Val Val Ala Lys Asp Asp Pro Asp His Tyr Lys Asp Tyr Ala Phe 
    50                  55                  60                  


Ile Gln Trp Thr Gly Gly Asn Ile Arg Asn Asp Asp Lys Tyr Thr His 
65                  70                  75                  80  


Phe Phe Ser Gly Phe Cys Asn Thr Met Cys Thr Glu Glu Thr Lys Arg 
                85                  90                  95      


Asn Ile Ala Arg His Leu Ala Leu Trp Asp Ser Asn Phe Phe Thr Glu 
            100                 105                 110         


Leu Glu Asn Lys Lys Val Glu Tyr Val Val Ile Val Glu Asn Asp Asn 
        115                 120                 125             


Val Ile Ala Ala Ile Ala Ala Ala Ala Pro Val Leu Lys Ala Met His 
    130                 135                 140                 


Asp Lys Lys Ile Asp Ile Leu Gln Met Ala Ala Ala Ile Thr Gly Asn 
145                 150                 155                 160 


Ala Val Lys Thr Glu Ala Ala Ala Asp Lys Asn His Ala Ile Phe Thr 
                165                 170                 175     


Tyr Thr Gly Gly Tyr Asp Val Ser Leu Ser Ala Tyr Ile Ile Arg Val 
            180                 185                 190         


Thr Thr Ala Leu Asn Ala Ala Asp Glu Ile Ile Lys Ser Gly Gly Leu 
        195                 200                 205             


Ser Ser Gly Phe Tyr Phe Glu Ile Ala Arg Ile Glu Asn Glu Met Lys 
    210                 215                 220                 


Ile Asn Ala Gln Ile Leu Asp Asn Ala Ala Lys Tyr Val Glu His Asp 
225                 230                 235                 240 


Pro Arg Leu Val Ala Glu His Arg Phe Ala Ala Ala Ala Ala Ala Ala 
                245                 250                 255     


Trp Ala Arg Ile Gly Pro Ala Thr Thr Ile Arg Cys Pro Gly Val Lys 
            260                 265                 270         


Asn Ala Asn Thr Ala Pro Leu Ile Ser Phe Phe Gly Leu Phe Asp Ile 
        275                 280                 285             


Asn Val Ile Gly Leu Ile Val Ile Leu Phe Ile Met Phe Met Leu Ile 
    290                 295                 300                 


Phe Asn Val Lys Ser Lys Leu Leu Trp Phe Leu Thr Gly Thr Phe Val 
305                 310                 315                 320 


Thr Ala Phe Ile 
                


<210>  171
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequences for Mutant H3L

<400>  171
atggctgccg ccaaaacccc cgtgattgtg gtccccgtgg ccgctgctct gccttccgag       60

acattcccca acgtgcacga acacatcaat gaccaagctg ccgctgacgt ggccgacgcc      120

gaagtcatgg ccgctaagag aaacgtggtc gtggccaagg atgaccccga ccactacaag      180

gactatgcct tcatccagtg gactggtggc aacatcagaa acgacgacaa gtacacccat      240

ttcttcagcg gcttctgcaa caccatgtgt accgaggaga ccaagaggaa catcgctcgt      300

cacctcgccc tctgggactc caatttcttc accgagctgg agaacaagaa ggtcgagtac      360

gtggtgatcg tggagaacga caacgtgatc gccgctatcg ctgccgccgc tcccgtttta      420

aaagccatgc acgacaagaa gatcgacatt ttacagatgg ccgctgccat caccggaaac      480

gccgtcaaga ccgaggctgc cgccgataag aaccacgcca tcttcaccta caccggcgga      540

tatgacgtga gcctctccgc ttacatcatt agggtgacca ccgctttaaa cgccgccgac      600

gaaatcatca aatccggagg tttaagctcc ggcttctact tcgagatcgc tcgtatcgag      660

aatgaaatga agatcaatgc ccagatttta gataatgccg ccaaatacgt ggaacatgac      720

cctcgtctgg tggctgagca tcgttttgct gctgctgccg ctgctgcttg ggccagaatc      780

ggacccgcca ccaccattag atgccccggt gtgaaaaacg ccaacaccgc ccctttaatt      840

tccttcttcg gtttattcga catcaacgtg atcggcctca tcgtgatttt attcatcatg      900

ttcatgctga tcttcaacgt gaagtccaag ttattatggt ttttaactgg taccttcgtg      960

accgccttca tctgataa                                                    978


<210>  172
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant D8L amino acid sequence

<400>  172

Met Pro Gln Gln Leu Ser Pro Ile Asn Ile Glu Thr Lys Lys Ala Ile 
1               5                   10                  15      


Ser Asn Ala Arg Leu Lys Pro Leu Asp Ile His Tyr Asn Glu Ser Lys 
            20                  25                  30          


Pro Thr Thr Ile Gln Asn Thr Gly Lys Leu Ala Ala Ile Asn Phe Ala 
        35                  40                  45              


Gly Gly Tyr Ile Ala Ala Ala Phe Leu Pro Asn Glu Tyr Val Leu Ser 
    50                  55                  60                  


Ser Leu His Ile Tyr Trp Gly Lys Glu Asp Asp Tyr Gly Ser Asn His 
65                  70                  75                  80  


Leu Ile Asp Val Tyr Lys Tyr Ser Gly Glu Ile Asn Leu Val His Trp 
                85                  90                  95      


Asn Ala Lys Lys Tyr Ser Ser Tyr Glu Glu Ala Ala Ala His Asp Asp 
            100                 105                 110         


Gly Leu Ile Ile Ile Ser Ile Phe Leu Gln Val Leu Asp His Lys Asn 
        115                 120                 125             


Val Tyr Phe Gln Lys Ile Val Asn Gln Leu Asp Ser Ile Arg Ser Gly 
    130                 135                 140                 


Asn Thr Ser Ala Pro Phe Asp Ser Val Phe Tyr Leu Asp Asn Leu Leu 
145                 150                 155                 160 


Pro Ser Lys Leu Asp Tyr Phe Ala Tyr Leu Gly Thr Thr Ile Asn His 
                165                 170                 175     


Ala Ala Asp Ala Val Trp Ile Ile Phe Pro Thr Pro Ile Asn Ile His 
            180                 185                 190         


Ser Asp Gln Ala Ser Lys Ala Arg Thr Leu Ala Ser Ser Ser Ala His 
        195                 200                 205             


Asp Gly Lys Ala His Tyr Ile Thr Glu Ala Tyr Ala Asn Ala Tyr Lys 
    210                 215                 220                 


Leu Asn Ala Asp Thr Gln Val Tyr Tyr Ser Gly Glu Ile Ile Arg Ala 
225                 230                 235                 240 


Ala Thr Thr Ser Pro Ala Arg Glu Asn Tyr Phe Met Arg Trp Leu Ser 
                245                 250                 255     


Asp Leu Arg Glu Thr Cys Phe Ser Tyr Tyr Gln Lys Tyr Ile Glu Glu 
            260                 265                 270         


Asn Lys Thr Phe Ala Ile Ile Ala Ile Val Phe Val Phe Ile Leu Thr 
        275                 280                 285             


Ala Ile Leu Phe Phe Met Ser Arg Arg Tyr Ser Arg Glu Lys Gln Asn 
    290                 295                 300                 


<210>  173
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequences for Mutant D8L

<400>  173
atgccccagc aactgtctcc catcaacatc gagaccaaga aggccatttc caacgctcgt       60

ctgaagcctt tagacatcca ctacaatgag agcaagccca ccaccatcca gaacactggt      120

aagctggccg ccatcaactt tgccggcggc tacatcgccg ccgcctttct gcccaacgag      180

tacgtgctca gctctttaca catctattgg ggcaaagagg acgactacgg ctccaaccat      240

ttaatcgacg tctacaagta ttccggcgag atcaatttag tgcactggaa cgccaagaag      300

tactccagct acgaagaagc cgctgcccac gacgacggac tgatcatcat cagcatcttt      360

ctccaagttc tggaccacaa gaacgtgtac ttccagaaga tcgtcaacca gctcgacagc      420

attcgttccg gcaatacatc cgcccccttt gattccgtgt tctatttaga caatttactg      480

ccctccaagc tggactactt cgcctattta ggcaccacca tcaatcacgc cgccgatgct      540

gtgtggatca tcttccccac ccccattaac attcacagcg atcaagctag caaggccaga      600

actttagcct ccagcagcgc tcacgacggc aaggctcact acatcaccga ggcctatgcc      660

aacgcctaca agctcaacgc cgacacccaa gtttactact ccggtgagat cattagagct      720

gccacaacct cccccgctcg tgagaactac ttcatgaggt ggctgtccga tttaagagag      780

acttgtttct cctactatca gaaatacatc gaggagaaca agaccttcgc catcatcgcc      840

atcgtgttcg tgttcatttt aaccgccatt ttattcttca tgtctcgtag gtactctcgt      900

gagaagcaga attgataa                                                    918


<210>  174
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant D8L amino acid sequence (Alternate for Seq No. 6 - only 
       different at position 43)

<400>  174

Met Pro Gln Gln Leu Ser Pro Ile Asn Ile Glu Thr Lys Lys Ala Ile 
1               5                   10                  15      


Ser Asn Ala Arg Leu Lys Pro Leu Asp Ile His Tyr Asn Glu Ser Lys 
            20                  25                  30          


Pro Thr Thr Ile Gln Asn Thr Gly Lys Leu Leu Trp Ile Asn Phe Lys 
        35                  40                  45              


Gly Gly Tyr Ile Ser Gly Trp Phe Leu Pro Asn Glu Tyr Val Leu Ser 
    50                  55                  60                  


Ser Leu His Ile Tyr Trp Gly Lys Glu Asp Asp Tyr Gly Ser Asn His 
65                  70                  75                  80  


Leu Ile Asp Val Tyr Lys Tyr Ser Gly Glu Ile Asn Leu Val His Trp 
                85                  90                  95      


Asn Lys Lys Lys Tyr Ser Ser Tyr Glu Glu Ala Lys Lys His Asp Asp 
            100                 105                 110         


Gly Leu Ile Ile Ile Ser Ile Phe Leu Gln Val Leu Asp His Lys Asn 
        115                 120                 125             


Val Tyr Phe Gln Lys Ile Val Asn Gln Leu Asp Ser Ile Arg Ser Thr 
    130                 135                 140                 


Asn Thr Ser Ala Pro Phe Asp Ser Val Phe Tyr Leu Asp Asn Leu Leu 
145                 150                 155                 160 


Pro Ser Lys Leu Asp Tyr Phe Ser Tyr Leu Gly Thr Thr Ile Asn His 
                165                 170                 175     


Tyr Ala Asp Ala Val Trp Ile Ile Phe Pro Thr Pro Ile Asn Ile His 
            180                 185                 190         


Ser Asp Gln Leu Ser Lys Tyr Arg Thr Leu Ser Ser Ser Ser Asn His 
        195                 200                 205             


Asp Gly Lys Thr His Tyr Ile Thr Glu Cys Tyr Arg Asn Leu Tyr Lys 
    210                 215                 220                 


Leu Asn Gly Asp Thr Gln Val Tyr Tyr Ser Gly Glu Ile Ile Arg Ala 
225                 230                 235                 240 


Ala Thr Thr Ser Pro Ala Arg Glu Asn Tyr Phe Met Arg Trp Leu Ser 
                245                 250                 255     


Asp Leu Arg Glu Thr Cys Phe Ser Tyr Tyr Gln Lys Tyr Ile Glu Glu 
            260                 265                 270         


Asn Lys Thr Phe Ala Ile Ile Ala Ile Val Phe Val Phe Ile Leu Thr 
        275                 280                 285             


Ala Ile Leu Phe Phe Met Ser Arg Arg Tyr Ser Arg Glu Lys Gln Asn 
    290                 295                 300                 


