                         SEQUENCE LISTING

<110>  James, Michael A
 
<120>  Targeting CLPTM1L for Treatment and Prevention of Cancer

<130>  650053.00643

<150>  US 62/750,450
<151>  2018-10-25

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  1617
<212>  DNA
<213>  Homo sapiens

<400>  1
atgtggagcg gccgcagctc cttcaccagc ttggtggtgg gcgtgttcgt ggtctacgtg       60

gtgcacacct gctgggtcat gtacggcatc gtctacaccc gcccgtgctc cggcgacgcc      120

aactgcatcc agccctacct ggcgcggcgg cccaagctgc agctgagcgt gtacaccacg      180

acgaggtccc acctgggtgc tgagaacaac atcgacctgg tcttgaatgt ggaagacttt      240

gatgtggagt ccaaatttga aaggacagtt aatgtttctg taccaaagaa aacgagaaac      300

aatgggacgc tgtatgccta catcttcctc catcacgctg gggtcctgcc gtggcacgac      360

gggaagcagg tgcacctggt cagtcctctg accacctaca tggtccccaa gccagaagaa      420

atcaacctgc tcaccgggga gtctgataca cagcagatcg aggcggagaa gaagccgacg      480

agtgccctgg atgagccagt gtcccactgg cgaccgcggc tggcgctgaa cgtgatggcg      540

gacaactttg tctttgacgg gtcctccctg cctgccgatg tgcatcggta catgaagatg      600

atccagctgg ggaaaaccgt gcattacctg cccatcctgt tcatcgacca gctcagcaac      660

cgcgtgaagg acctgatggt cataaaccgc tccaccaccg agctgcccct caccgtgtcc      720

tacgacaagg tctcactggg gcggctgcgc ttctggatcc acatgcagga cgccgtgtac      780

tccctgcagc agttcgggtt ttcagagaaa gatgctgatg aggtgaaagg aatttttgta      840

gataccaact tatacttcct ggcgctgacc ttctttgtcg cagcgttcca tcttctcttt      900

gatttcctgg cctttaaaaa tgacatcagt ttctggaaga agaagaagag catgatcggc      960

atgtccacca aggcagtgct ctggcgctgc ttcagcaccg tggtcatctt tctgttcctg     1020

ctggacgagc agacgagcct gctggtgctg gtcccggcgg gtgttggagc cgccattgag     1080

ctgtggaaag tgaagaaggc attgaagatg actatttttt ggagaggcct gatgcccgaa     1140

tttcagtttg gcacttacag cgaatctgag aggaaaaccg aggagtacga tactcaggcc     1200

atgaagtact tgtcatacct gctgtaccct ctctgtgtcg ggggtgctgt ctattcactc     1260

ctgaatatca aatataagag ctggtactcc tggttaatca acagcttcgt caacggggtc     1320

tatgcctttg gtttcctctt catgctgccc cagctctttg tgaactacaa gttgaagtca     1380

gtggcacatc tgccctggaa ggccttcacc tacaaggctt tcaacacctt cattgatgac     1440

gtctttgcct tcatcatcac catgcccacg tctcaccggc tggcctgctt ccgggacgac     1500

gtggtgtttc tggtctacct gtaccagcgg tggctttatc ctgtggataa acgcagagtg     1560

aacgagtttg gggagtccta cgaggagaag gccacgcggg cgccccacac ggactga        1617


<210>  2
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Ser Gly Arg Ser Ser Phe Thr Ser Leu Val Val Gly Val Phe 
1               5                   10                  15      


Val Val Tyr Val Val His Thr Cys Trp Val Met Tyr Gly Ile Val Tyr 
            20                  25                  30          


Thr Arg Pro Cys Ser Gly Asp Ala Asn Cys Ile Gln Pro Tyr Leu Ala 
        35                  40                  45              


Arg Arg Pro Lys Leu Gln Leu Ser Val Tyr Thr Thr Thr Arg Ser His 
    50                  55                  60                  


Leu Gly Ala Glu Asn Asn Ile Asp Leu Val Leu Asn Val Glu Asp Phe 
65                  70                  75                  80  


Asp Val Glu Ser Lys Phe Glu Arg Thr Val Asn Val Ser Val Pro Lys 
                85                  90                  95      


Lys Thr Arg Asn Asn Gly Thr Leu Tyr Ala Tyr Ile Phe Leu His His 
            100                 105                 110         


Ala Gly Val Leu Pro Trp His Asp Gly Lys Gln Val His Leu Val Ser 
        115                 120                 125             


Pro Leu Thr Thr Tyr Met Val Pro Lys Pro Glu Glu Ile Asn Leu Leu 
    130                 135                 140                 


Thr Gly Glu Ser Asp Thr Gln Gln Ile Glu Ala Glu Lys Lys Pro Thr 
145                 150                 155                 160 


Ser Ala Leu Asp Glu Pro Val Ser His Trp Arg Pro Arg Leu Ala Leu 
                165                 170                 175     


Asn Val Met Ala Asp Asn Phe Val Phe Asp Gly Ser Ser Leu Pro Ala 
            180                 185                 190         


Asp Val His Arg Tyr Met Lys Met Ile Gln Leu Gly Lys Thr Val His 
        195                 200                 205             


Tyr Leu Pro Ile Leu Phe Ile Asp Gln Leu Ser Asn Arg Val Lys Asp 
    210                 215                 220                 


Leu Met Val Ile Asn Arg Ser Thr Thr Glu Leu Pro Leu Thr Val Ser 
225                 230                 235                 240 


Tyr Asp Lys Val Ser Leu Gly Arg Leu Arg Phe Trp Ile His Met Gln 
                245                 250                 255     


Asp Ala Val Tyr Ser Leu Gln Gln Phe Gly Phe Ser Glu Lys Asp Ala 
            260                 265                 270         


Asp Glu Val Lys Gly Ile Phe Val Asp Thr Asn Leu Tyr Phe Leu Ala 
        275                 280                 285             


Leu Thr Phe Phe Val Ala Ala Phe His Leu Leu Phe Asp Phe Leu Ala 
    290                 295                 300                 


Phe Lys Asn Asp Ile Ser Phe Trp Lys Lys Lys Lys Ser Met Ile Gly 
305                 310                 315                 320 


Met Ser Thr Lys Ala Val Leu Trp Arg Cys Phe Ser Thr Val Val Ile 
                325                 330                 335     


Phe Leu Phe Leu Leu Asp Glu Gln Thr Ser Leu Leu Val Leu Val Pro 
            340                 345                 350         


Ala Gly Val Gly Ala Ala Ile Glu Leu Trp Lys Val Lys Lys Ala Leu 
        355                 360                 365             


Lys Met Thr Ile Phe Trp Arg Gly Leu Met Pro Glu Phe Gln Phe Gly 
    370                 375                 380                 


Thr Tyr Ser Glu Ser Glu Arg Lys Thr Glu Glu Tyr Asp Thr Gln Ala 
385                 390                 395                 400 


Met Lys Tyr Leu Ser Tyr Leu Leu Tyr Pro Leu Cys Val Gly Gly Ala 
                405                 410                 415     


Val Tyr Ser Leu Leu Asn Ile Lys Tyr Lys Ser Trp Tyr Ser Trp Leu 
            420                 425                 430         


Ile Asn Ser Phe Val Asn Gly Val Tyr Ala Phe Gly Phe Leu Phe Met 
        435                 440                 445             


Leu Pro Gln Leu Phe Val Asn Tyr Lys Leu Lys Ser Val Ala His Leu 
    450                 455                 460                 


Pro Trp Lys Ala Phe Thr Tyr Lys Ala Phe Asn Thr Phe Ile Asp Asp 
465                 470                 475                 480 


Val Phe Ala Phe Ile Ile Thr Met Pro Thr Ser His Arg Leu Ala Cys 
                485                 490                 495     


Phe Arg Asp Asp Val Val Phe Leu Val Tyr Leu Tyr Gln Arg Trp Leu 
            500                 505                 510         


Tyr Pro Val Asp Lys Arg Arg Val Asn Glu Phe Gly Glu Ser Tyr Glu 
        515                 520                 525             


Glu Lys Ala Thr Arg Ala Pro His Thr Asp 
    530                 535             


<210>  3
<211>  1759
<212>  DNA
<213>  Homo sapiens

<400>  3
ctctgaccac ctacatggtc cccaagccag aagaaatcaa cctgctcacc ggggagtctg       60

atacacagca gatcgaggcg gagaagaagc cgacgagtgc cctggatgag ccagtgtccc      120

actggcgacc gcggctggcg ctgaacgtga tggcggacaa ctttgtcttt gacgggtcct      180

ccctgcctgc cgatgtgcat cggtacatga agatgatcca gctggggaaa accgtgcatt      240

acctgcccat cctgttcatc gaccagctca gcaaccgcgt gaaggacctg atggtcataa      300

accgctccac caccgagctg cccctcaccg tgtcctacga caaggtctca ctggggcggc      360

tgcgcttctg gatccacatg caggacgccg tgtactccct gcagcagttc gggttttcag      420

agaaagatgc tgatgaggtg aaaggaattt ttgtagatac caacttatac ttcctggcgc      480

tgaccttctt tgtcgcagcg ttccatcttc tctttgattt cctggccttt aaaaatgaca      540

tcagtttctg gaagaagaag aagagcatga tcggcatgtc caccaagctg tggaaagtga      600

agaaggcatt gaagatgact attttttgga gaggcctgat gcccgaattt cagtttggca      660

cttacagcga atctgagagg aaaaccgagg agtacgatac tcaggccatg aagtacttgt      720

catacctgct gtaccctctc tgtgtcgggg gtgctgtcta ttcactcctg aatatcaaat      780

ataagagctg gtactcctgg ttaatcaaca gcttcgtcaa cggggtctat gcctttggtt      840

tcctcttcat gctgccccag ctctttgtga actacaagtt gaagtcagtg gcacatctgc      900

cctggaaggc cttcacctac aaggctttca acaccttcat tgatgacgtc tttgccttca      960

tcatcaccat gcccacgtct caccggctgg cctgcttccg ggacgacgtg gtgtttctgg     1020

tctacctgta ccagcggtgg ctttatcctg tggataaacg cagagtgaac gagtttgggg     1080

agtcctacga ggagaaggcc acgcgggcgc cccacacgga ctgaaggccg cccgggctgc     1140

cgccagccaa gtgcaacttg aattgtcaat gagtattttt ggaagcattt ggaggaattc     1200

ctagacattg cgttttctgt gttgccaaaa tcccttcgga catttctcag acatctccca     1260

agttcccatc acgtcagatt tggagctggt agcgcttacg atgcccccac gtgtgaacat     1320

ctgtcttggt cacagagctg ggtgctgccg gtcaccttga gctgtggtgg ctcccggcac     1380

acgagtgtcc ggggttcggc catgtcctca cgcgggcagg ggtgggagcc ctcacaggca     1440

agggggctgt tggatttcca tttcaggtgg ttttctaagt gctccttatg tgaatttcaa     1500

acacgtatgg aattcattcc gcatggactc tgggatcaaa ggctctttcc tcttttgttt     1560

gagagttggt tgttttaaag cttaatgtat gtttctattt taaaataaat ttttctggct     1620

gtggcatttt tcttgacctg gtataatgaa agtatttcag atatttgagt ttaacccttt     1680

tccagaaagt aatacatgat atggatttat ttatgcatta aaagagcaaa tttaaagagc     1740

aaaaaaaaaa aaaaaaaaa                                                  1759


<210>  4
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Arg Pro Lys Leu Gln Leu Ser Val Tyr Thr Thr 
1               5                   10          


<210>  5
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Asn Asn Ile Asp Leu Val Leu Asn Val Glu Asp 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Asp Phe Asp Val Glu Ser Lys Phe Glu Arg Thr 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  7

His Ala Gly Val Leu Pro Trp His Asp Gly Lys Gln 
1               5                   10          


<210>  8
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Gly Ser Ser Leu Pro Ala Asp Val His Arg Tyr 
1               5                   10          


<210>  9
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  9

His Arg Tyr Met Lys Met Ile Gln Leu Gly Lys Thr 
1               5                   10          


<210>  10
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Glu Leu Pro Leu Thr Val Ser Tyr Asp Lys Val 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Gln Phe Gly Phe Ser Glu Lys Asp Ala Asp Glu 
1               5                   10          


<210>  12
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  12

Thr Arg Pro Cys Ser Gly Asp Ala Asn Cys 
1               5                   10  


<210>  13
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Arg Pro Lys Leu Gln Leu Ser Val Tyr Thr Thr 
1               5                   10          


<210>  14
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Asn Asn Ile Asp Leu Val Leu Asn Val Glu 
1               5                   10      


<210>  15
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  15

Phe Asp Val Glu Ser Lys Phe Glu Arg Thr 
1               5                   10  


<210>  16
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  16

His Ala Gly Val Leu Pro Trp His Asp Gly Lys Gln 
1               5                   10          


<210>  17
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Thr Tyr Met Val Pro Lys Pro Glu Glu 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  18

Ile Asn Leu Leu Thr Gly Glu Ser Asp Thr 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Ser Asp Thr Gln Gln Ile Glu Ala Glu 
1               5                   10  


<210>  20
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys Lys Pro Thr Ser Ala Leu Asp Glu Pro Val 
1               5                   10      


<210>  21
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Gly Ser Ser Leu Pro Ala Asp Val His 
1               5                   10  


<210>  22
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  22

His Arg Tyr Met Lys Met Ile Gln Leu Gly Lys Thr 
1               5                   10          


<210>  23
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  23

Leu Pro Leu Thr Val Ser Tyr Asp Lys Val 
1               5                   10  


<210>  24
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gln Asp Ala Val Tyr Ser Leu Gln Gln Phe 
1               5                   10      


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Phe Ser Glu Lys Asp Ala Asp Glu 
1               5                   


<210>  26
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-1 heavy chain V

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Ser Arg Leu Glu Ile Leu Leu Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  27
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-1 light chain V

<400>  27

Val His Val Ile Leu Thr Gln Pro Pro Ser Leu Ser Ala Ala Pro Gly 
1               5                   10                  15      


Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Asp Ser Asn Ile Gly Asn 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Arg Gln Phe Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ile Leu Asp Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Thr Ser 
                85                  90                  95      


Leu Asp Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  28
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-4 heavy chain V

<400>  28

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  29
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-4 light chain V

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ile Ile Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Tyr Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Arg Thr Lys Leu Asp Ile Lys 
            100                 105         


<210>  30
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-5 heavy chain V

<400>  30

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Gly Gly Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Arg Lys Trp Leu Gln Leu Leu Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  31
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-5 light chain V

<400>  31

Gln Ala Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ala Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Lys Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  32
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-22 heavy chain V

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Thr Gly Gly Tyr His Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu 
        


<210>  33
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-22 light chain V

<400>  33

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  34
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-27 heavy chain V

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Thr Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Ile Asp Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Leu Thr Val Thr Ala Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ile Asn Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Pro Arg Arg Tyr Gly Asp Tyr Glu Tyr Phe Glu Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  35
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-27 light chain V

<400>  35

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Phe Pro Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala 
        35                  40                  45              


Leu Ile Tyr Ser Thr Ser Asn Arg His Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Ile Tyr Ser Gly Gly 
                85                  90                  95      


Val Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-1 VH CDR1

<400>  36

Gly Gly Thr Phe Ser Ser Tyr 
1               5           


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-1 VH CDR2

<400>  37

Asn Pro Ser Gly Gly Ser 
1               5       


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-1 VH CDR3

<400>  38

Gly Gly Leu Ser Arg Leu Glu Ile Leu Leu Asp 
1               5                   10      


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-1 VL CDR1

<400>  39

Ser Gly Ser Asp Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-1 VL CDR2

<400>  40

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-1 VL CDR3

<400>  41

Gly Ser Trp Asp Thr Ser Leu Asp Ala Trp Val 
1               5                   10      


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-4 VH CDR1

<400>  42

Gly Phe Thr Phe Lys Asn Tyr 
1               5           


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-4 VH CDR2

<400>  43

Ser Trp Asn Ser Gly Ser 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-4 VH CDR3

<400>  44

Ser Arg Tyr Ser Asp Tyr 
1               5       


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-4 VL CDR1

<400>  45

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-4 VL CDR2

<400>  46

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-4 VL CDR3

<400>  47

Leu Gln Asp Tyr Asn Tyr Pro Trp Thr 
1               5                   


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-5 VH CDR1

<400>  48

Gly Phe Ser Phe Ser Ser Tyr 
1               5           


<210>  49
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-5 VH CDR2

<400>  49

Ser Ser Gly Gly Gly Thr 
1               5       


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-5 VH CDR3

<400>  50

Asp Arg Gly Arg Lys Trp Leu Gln Leu Leu Phe Asp Ser 
1               5                   10              


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-5 VL CDR1

<400>  51

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-5 VL CDR2

<400>  52

Thr Asn Asn Gln Arg Pro Ser 
1               5           


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-5 VL CDR3

<400>  53

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-22 VH CDR1

<400>  54

Gly Phe Thr Phe Asp Asp Tyr 
1               5           


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-22 VH CDR2

<400>  55

Asn Trp Asn Gly Gly Ser 
1               5       


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-22 VH CDR3

<400>  56

Leu Thr Gly Gly Tyr His Gly Met Asp Val 
1               5                   10  


<210>  57
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-22 VL CDR1

<400>  57

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10              


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-22 VL CDR2

<400>  58

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-22 VL CDR3

<400>  59

Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Trp Val 
1               5                   10          


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-27 VH CDR1

<400>  60

Gly Gly Thr Phe Ser Ile Tyr 
1               5           


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-27 VH CDR2

<400>  61

Ile Pro Met Ile Asp Thr 
1               5       


<210>  62
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-27 VH CDR3

<400>  62

Asp Pro Arg Arg Tyr Gly Asp Tyr Glu Tyr Phe Glu Phe 
1               5                   10              


<210>  63
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-27 VL CDR1

<400>  63

Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Phe Pro Asn 
1               5                   10                  


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-27 VL CDR2

<400>  64

Ser Thr Ser Asn Arg His Pro 
1               5           


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Anti-CRR9/CLPTM1L clone 102-27 VL CDR3

<400>  65

Leu Ile Tyr Ser Gly Gly Val Tyr Val 
1               5                   


<210>  66
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- anti-CRR9 clone 102-21 codon-optimized DNA sequence

<400>  66
cacgtgatcc tgacacagcc tcctagcctg tctgctgccc ctggacagag agtgaccatc       60

agctgtagcg gcagcgacag caacatcggc aacaactacg tgtcctggta cagacagttc      120

cccggcacag cccctaagct gctgatctac gacaacaaca agcggcctag cggcgtgccc      180

gatagatttt ctggcagcaa gagcggcacc agcgccatcc tggatattac aggactgcag      240

gccggcgacg aggccgatta ctattgtggc agctgggaca ccagcctgga cgcttgggtt      300

ttcggcggag gcacaaagct gacagtgctt ggaggcggag gatctggcgg cggaggaagc      360

ggaggcggtt ctggcggtgg tggatctgaa gttcagctgc tggaatctgg cgccgaagtg      420

aagaaacctg gcagcagcgt gaaggtgtcc tgcaaagctt ctggcggcac cttcagcagc      480

tacgccatct cttgggttcg acaggcccca ggacaaggcc tggaatggat gggcatcatc      540

aatccaagcg gcggcagcac aagctacgcc cagaaattcc agggcagagt gacaatgacc      600

agagacacca gcacctccac cgtgtacatg gaactgagca gcctgagaag cgaggacacc      660

gccgtgtact actgtgctag aggcggcctg agccggctgg aaatcctgct ggataattgg      720

ggccagggca ccctggtcac agtgtcatct                                       750


<210>  67
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- anti-CRR9 clone 102-4 codon-optimized DNA sequence

<400>  67
gaagtgcagc tgctggaatc tggtggcgga gttgttcagc ctggcggctc tctgtctctg       60

tcttgtgccg ccagcggctt caccttcaag aactacggca tgcactgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccggc atcagctgga atagcggctc tatcggctac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc cagaagccgg      300

tacagcgact attggggcca gggcacactg gtcacagttt ctagcggagg cggaggaagt      360

ggcggcggag gatctggcgg tggtagtggc ggtggcggtt ctgacattca gatgacacag      420

agccccagca gcctgtctgc ctctgtggga gacagagtga caatcgcctg cagagccagc      480

cagggcatca gaaatgacct cggctggtat cagcagaagc ccggcaaagc ccctaagctg      540

ctgatctatg ccgcctcctc tctgcaatct ggcgtgccct ctagattttc cggctctggc      600

agcggcaccg acttcaccct gaccatcatc atcctgcagc ctgaggacta cgccacctac      660

tactgcctgc aagactacaa ctacccctgg accttcggcc agaggaccaa gctggatatc      720

aag                                                                    723


<210>  68
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- anti-CRR9 clone 102-5 codon-optimized DNA sequence

<400>  68
caggctgtgc tgactcagcc gccctcagcg tctgggaccc ccgggcagaa ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta ccaacagctc      120

ccaggaacgg cccccaaact cctcatctat actaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcgcc tcagcctccc tggccatcag tgggctccag      240

tctaaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggttgggtg      300

ttcggcggag ggaccaagct caccgtccta ggtgagggta aatcttccgg atctggttcc      360

gaatccaaag ctagcgaggt gcagctgttg gagtctgggg gaggcttggt tcagccggga      420

gggtccctga gactctcctg tgcagcctct ggattcagct tcagtagtta tgaaatgaac      480

tgggtccgcc aggctccagg caaggggccg gagtggattt catacatcag cagtggtggt      540

ggtaccatat actacgcaga ctccgtgagg ggccgattca ccatctccag agacaactcc      600

aacaacactc tgtatctgca aatgaacagc ctgagacctg acgacacggc tatttattac      660

tgtgcgagag accggggacg gaaatggcta caactattgt ttgactcctg gggccagggc      720

accctggtca ccgtctcctc a                                                741


<210>  69
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- anti-CRR9 clone 102-22 codon-optimized DNA sequence

<400>  69
cagtctgtgc tgacacagcc tccatctgcc tctggcacac ctggccagag agtgaccatc       60

agctgtagcg gcagcagcag caacatcggc agcaactacg tgtactggta tcagcagctg      120

cccggcacag cccctaaact gctgatctac cggaacaacc agcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatctc tggactgaga      240

agcgaggacg aggccgacta ctattgtgcc gcctgggatg atagcctgag cggcccttgg      300

gttttcggcg gaggcacaaa agtgacagtg ctcggaggcg gaggatctgg tggcggaggt      360

agtggcggtg gttctggcgg aggcggttct gaagttcagc tggtggaaag tggcggcgga      420

gtcgttagac ctggcggatc tctgagactg tcttgcgccg ccagcggctt caccttcgat      480

gattacggca tgagctgggt ccgacaggcc cctggaaaag gccttgaatg ggtgtccggc      540

atcaactgga atggcggctc tacaggctac gccgactctg tgaagggcag attcaccatc      600

agccgggaca acgccaagaa cagcctgtac ctgcagatga actccctgag agccgaggac      660

accgccgtgt actactgtgc atctctgaca ggcggctacc acggcatgga tgtttgggga      720

cagggcaccc tggtcaccgt ttcttct                                          747


<210>  70
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- anti-CRR9 clone 102-27 codon-optimized DNA sequence

<400>  70
cagaccgtgg tcacacaaga gcctagcctg acagtgtctc ctggcggcac agtgacactg       60

acatgtgcct cttctactgg cgccgtgacc agcggctact tccccaattg gttccagcag      120

aagcctggac aggcccctag ggctctgatc tacagcacca gcaacagaca cccctggaca      180

cccgccagat tttctggctc tctgctcgga ggaaaggccg ctctgacact gtctggtgtc      240

cagcctgagg acgaggccga ttactactgc ctgatctact ctggcggcgt gtacgtgttc      300

ggcaccggca caaaactgac agtgcttggc ggcggaggat ctggcggagg tggaagcgga      360

ggcggtagtg gtggtggcgg atctgaagtg cagctggtgg aatctggcgc cgaagtgaag      420

aaacctggca gcagcgtgaa ggtgtcctgc aaagctagcg gcggcacctt cagcatctac      480

gccacaaact gggtccgaca ggctccagga caaggccctg aatggatggg cggcatcatc      540

cccatgatcg acaccaccaa ctacgcccag aagttccggg gcagactgac cgtgacagcc      600

gacaagtcta cccggaccgc ctacatggaa ctgatcaacc tgaccagcga cgacaccgcc      660

gtgtactatt gtgctggcga ccccagaaga tacggcgact acgagtactt cgagttctgg      720

ggccagggca ccctggtcac agtttcttct                                       750


<210>  71
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Val Pro Lys Pro Glu Glu Ile Asn Leu Leu Thr Gly Glu Ser Asp 
1               5                   10                  15      


Thr Gln Gln Ile Glu Ala Glu Lys Lys Pro Thr Ser Ala Leu Asp Glu 
            20                  25                  30          


Pro Val Ser His Trp Arg Pro Arg Leu Ala Leu Asn Val Met Ala Asp 
        35                  40                  45              


Asn Phe Val Phe Asp Gly Ser Ser Leu Pro Ala Asp Val His Arg Tyr 
    50                  55                  60                  


Met Lys Met Ile Gln Leu Gly Lys Thr Val His Tyr Leu Pro Ile Leu 
65                  70                  75                  80  


Phe Ile Asp Gln Leu Ser Asn Arg Val Lys Asp Leu Met Val Ile Asn 
                85                  90                  95      


Arg Ser Thr Thr Glu Leu Pro Leu Thr Val Ser Tyr Asp Lys Val Ser 
            100                 105                 110         


Leu Gly Arg Leu Arg Phe Trp Ile His Met Gln Asp Ala Val Tyr Ser 
        115                 120                 125             


Leu Gln Gln Phe Gly Phe Ser Glu Lys Asp Ala Asp Glu Val Lys Gly 
    130                 135                 140                 


Ile Phe Val Asp Thr Asn Leu Tyr Phe Leu Ala Leu Thr Phe Phe Val 
145                 150                 155                 160 


Ala Ala Phe His Leu Leu Phe Asp Phe Leu Ala Phe Lys Asn Asp Ile 
                165                 170                 175     


Ser Phe Trp Lys Lys Lys Lys Ser Met Ile Gly Met Ser Thr Lys Leu 
            180                 185                 190         


Trp Lys Val Lys Lys Ala Leu Lys Met Thr Ile Phe Trp Arg Gly Leu 
        195                 200                 205             


Met Pro Glu Phe Gln Phe Gly Thr Tyr Ser Glu Ser Glu Arg Lys Thr 
    210                 215                 220                 


Glu Glu Tyr Asp Thr Gln Ala Met Lys Tyr Leu Ser Tyr Leu Leu Tyr 
225                 230                 235                 240 


Pro Leu Cys Val Gly Gly Ala Val Tyr Ser Leu Leu Asn Ile Lys Tyr 
                245                 250                 255     


Lys Ser Trp Tyr Ser Trp Leu Ile Asn Ser Phe Val Asn Gly Val Tyr 
            260                 265                 270         


Ala Phe Gly Phe Leu Phe Met Leu Pro Gln Leu Phe Val Asn Tyr Lys 
        275                 280                 285             


Leu Lys Ser Val Ala His Leu Pro Trp Lys Ala Phe Thr Tyr Lys Ala 
    290                 295                 300                 


Phe Asn Thr Phe Ile Asp Asp Val Phe Ala Phe Ile Ile Thr Met Pro 
305                 310                 315                 320 


Thr Ser His Arg Leu Ala Cys Phe Arg Asp Asp Val Val Phe Leu Val 
                325                 330                 335     


Tyr Leu Tyr Gln Arg Trp Leu Tyr Pro Val Asp Lys Arg Arg Val Asn 
            340                 345                 350         


Glu Phe Gly Glu Ser Tyr Glu Glu Lys Ala Thr Arg Ala Pro His Thr 
        355                 360                 365             


Asp 
    


