<110>    THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION
         Pusan National University Industry-University Cooperation Foundation

<120>    Novel use of extracellular vesicles derived from stem cells
         overexpressing SOD3

<130>    OP18-0180/PCT

<160>    8

<170>    KoPatentIn 3.0

<210>    1
<211>    240
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Human SOD3


<400>    1
Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser
  1               5                  10                  15 

Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala
             20                  25                  30 

Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu
         35                  40                  45 

Val Met Gln Arg Arg Asp Asp Asp Gly Ala Leu His Ala Ala Cys Gln
     50                  55                  60 

Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly
 65                  70                  75                  80 

Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe
                 85                  90                  95 

Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala
            100                 105                 110 

Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr
        115                 120                 125 

Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly
    130                 135                 140 

Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg
145                 150                 155                 160 

Ala Gly Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg
                165                 170                 175 

Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn
            180                 185                 190 

Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys
        195                 200                 205 

Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu
    210                 215                 220 

His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala Ala
225                 230                 235                 240


<210>    2
<211>    240
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Human SOD3:58T


<400>    2
Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser
  1               5                  10                  15 

Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala
             20                  25                  30 

Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu
         35                  40                  45 

Val Met Gln Arg Arg Asp Asp Asp Gly Thr Leu His Ala Ala Cys Gln
     50                  55                  60 

Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly
 65                  70                  75                  80 

Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe
                 85                  90                  95 

Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala
            100                 105                 110 

Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr
        115                 120                 125 

Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly
    130                 135                 140 

Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg
145                 150                 155                 160 

Ala Gly Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg
                165                 170                 175 

Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn
            180                 185                 190 

Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys
        195                 200                 205 

Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu
    210                 215                 220 

His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala Ala
225                 230                 235                 240


<210>    3
<211>    209
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Human 209E-SOD3(EC SOD)


<400>    3
Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala Glu Trp
  1               5                  10                  15 

Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu Val Met
             20                  25                  30 

Gln Arg Arg Asp Asp Asp Gly Ala Leu His Ala Ala Cys Gln Val Gln
         35                  40                  45 

Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly Val Val
     50                  55                  60 

Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe Phe Ala
 65                  70                  75                  80 

Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala Ile His
                 85                  90                  95 

Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr Gly Pro
            100                 105                 110 

His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly Asp Phe
        115                 120                 125 

Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg Ala Gly
    130                 135                 140 

Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg Ala Val
145                 150                 155                 160 

Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn Gln Ala
                165                 170                 175 

Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys Val Val
            180                 185                 190 

Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu His Ser
        195                 200                 205 

Glu
   


<210>    4
<211>    209
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Human 209E-SOD3:58T


<400>    4
Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala Glu Trp
  1               5                  10                  15 

Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu Val Met
             20                  25                  30 

Gln Arg Arg Asp Asp Asp Gly Thr Leu His Ala Ala Cys Gln Val Gln
         35                  40                  45 

Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly Val Val
     50                  55                  60 

Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe Phe Ala
 65                  70                  75                  80 

Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala Ile His
                 85                  90                  95 

Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr Gly Pro
            100                 105                 110 

His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly Asp Phe
        115                 120                 125 

Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg Ala Gly
    130                 135                 140 

Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg Ala Val
145                 150                 155                 160 

Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn Gln Ala
                165                 170                 175 

Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys Val Val
            180                 185                 190 

Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu His Ser
        195                 200                 205 

Glu
   


<210>    5
<211>    723
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    human SOD3 DNA


<400>    5
atgctggcgc tactgtgttc ctgcctgctc ctggcagccg gtgcctcgga cgcctggacg         60

ggcgaggact cggcggagcc caactctgac tcggcggagt ggatccgaga catgtacgcc        120

aaggtcacgg agatctggca ggaggtcatg cagcggcggg acgacgacgg cgcgctccac        180

gccgcctgcc aggtgcagcc gtcggccacg ctggacgccg cgcagccccg ggtgaccggc        240

gtcgtcctct tccggcagct tgcgccccgc gccaagctcg acgccttctt cgccctggag        300

ggcttcccga ccgagccgaa cagctccagc cgcgccatcc acgtgcacca gttcggggac        360

ctgagccagg gctgcgagtc caccgggccc cactacaacc cgctggccgt gccgcacccg        420

cagcacccgg gcgacttcgg caacttcgcg gtccgcgacg gcagcctctg gaggtaccgc        480

gccggcctgg ccgcctcgct cgcgggcccg cactccatcg tgggccgggc cgtggtcgtc        540

cacgctggcg aggacgacct gggccgcggc ggcaaccagg ccagcgtgga gaacgggaac        600

gcgggccggc ggctggcctg ctgcgtggtg ggcgtgtgcg ggcccgggct ctgggagcgc        660

caggcgcggg agcactcaga gcgcaagaag cggcggcgcg agagcgagtg caaggccgcc        720

tga                                                                      723


<210>    6
<211>    723
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Human SOD3:58T DNA


<400>    6
atgctggcgc tactgtgttc ctgcctgctc ctggcagccg gtgcctcgga cgcctggacg         60

ggcgaggact cggcggagcc caactctgac tcggcggagt ggatccgaga catgtacgcc        120

aaggtcacgg agatctggca ggaggtcatg cagcggcggg acgacgacgg cacgctccac        180

gccgcctgcc aggtgcagcc gtcggccacg ctggacgccg cgcagccccg ggtgaccggc        240

gtcgtcctct tccggcagct tgcgccccgc gccaagctcg acgccttctt cgccctggag        300

ggcttcccga ccgagccgaa cagctccagc cgcgccatcc acgtgcacca gttcggggac        360

ctgagccagg gctgcgagtc caccgggccc cactacaacc cgctggccgt gccgcacccg        420

cagcacccgg gcgacttcgg caacttcgcg gtccgcgacg gcagcctctg gaggtaccgc        480

gccggcctgg ccgcctcgct cgcgggcccg cactccatcg tgggccgggc cgtggtcgtc        540

cacgctggcg aggacgacct gggccgcggc ggcaaccagg ccagcgtgga gaacgggaac        600

gcgggccggc ggctggcctg ctgcgtggtg ggcgtgtgcg ggcccgggct ctgggagcgc        660

caggcgcggg agcactcaga gcgcaagaag cggcggcgcg agagcgagtg caaggccgcc        720

tga                                                                      723


<210>    7
<211>    627
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Human 209E-SOD3(EC SOD) DNA


<400>    7
tggacgggcg aggactcggc ggagcccaac tctgactcgg cggagtggat ccgagacatg         60

tacgccaagg tcacggagat ctggcaggag gtcatgcagc ggcgggacga cgacggcgcg        120

ctccacgccg cctgccaggt gcagccgtcg gccacgctgg acgccgcgca gccccgggtg        180

accggcgtcg tcctcttccg gcagcttgcg ccccgcgcca agctcgacgc cttcttcgcc        240

ctggagggct tcccgaccga gccgaacagc tccagccgcg ccatccacgt gcaccagttc        300

ggggacctga gccagggctg cgagtccacc gggccccact acaacccgct ggccgtgccg        360

cacccgcagc acccgggcga cttcggcaac ttcgcggtcc gcgacggcag cctctggagg        420

taccgcgccg gcctggccgc ctcgctcgcg ggcccgcact ccatcgtggg ccgggccgtg        480

gtcgtccacg ctggcgagga cgacctgggc cgcggcggca accaggccag cgtggagaac        540

gggaacgcgg gccggcggct ggcctgctgc gtggtgggcg tgtgcgggcc cgggctctgg        600

gagcgccagg cgcgggagca ctcagag                                            627


<210>    8
<211>    627
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Human 209E-SOD3:58T DNA


<400>    8
tggacgggcg aggactcggc ggagcccaac tctgactcgg cggagtggat ccgagacatg         60

tacgccaagg tcacggagat ctggcaggag gtcatgcagc ggcgggacga cgacggcacg        120

ctccacgccg cctgccaggt gcagccgtcg gccacgctgg acgccgcgca gccccgggtg        180

accggcgtcg tcctcttccg gcagcttgcg ccccgcgcca agctcgacgc cttcttcgcc        240

ctggagggct tcccgaccga gccgaacagc tccagccgcg ccatccacgt gcaccagttc        300

ggggacctga gccagggctg cgagtccacc gggccccact acaacccgct ggccgtgccg        360

cacccgcagc acccgggcga cttcggcaac ttcgcggtcc gcgacggcag cctctggagg        420

taccgcgccg gcctggccgc ctcgctcgcg ggcccgcact ccatcgtggg ccgggccgtg        480

gtcgtccacg ctggcgagga cgacctgggc cgcggcggca accaggccag cgtggagaac        540

gggaacgcgg gccggcggct ggcctgctgc gtggtgggcg tgtgcgggcc cgggctctgg        600

gagcgccagg cgcgggagca ctcagag                                            627
