                         SEQUENCE LISTING

<110>  Explore Bio 1 Ltd.
       ZHOU , Hongxing
       BOGIN, Oren
 
<120>  PRECURSOR BISPECIFIC ANTIBODY CONSTRUCTS AND METHODS OF USE THEREOF

<130>  P-579713-PC

<150>  62/748,544
<151>  2018-10-22

<160>  150   

<170>  PatentIn version 3.5

<210>  1
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  2
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val 
            100                 105                 110         


Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr 
        115                 120                 125             


Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala 
    130                 135                 140                 


Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro 
145                 150                 155                 160 


Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu 
                165                 170                 175     


Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
            180                 185 


<210>  3
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD3 epsilon extracellular

<400>  3

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp 
        115                 120                 125     


<210>  4
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD3 epsilon CAP

<400>  4

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
            20                  25          


<210>  5
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
1               5                   10                  15      


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
            20                  25                  30          


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
        35                  40                  45              


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
    50                  55                  60                  


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
65                  70                  75                  80  


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
                85                  90                  95      


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
            100                 105                 110         


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
        115                 120                 125             


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
    130                 135                 140                 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
145                 150                 155                 160 


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
                165                 170                 175     


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
            180                 185                 190         


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
        195                 200                 205             


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
    210                 215                 220                 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
225                 230                 235                 240 


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
                245                 250                 255     


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
            260                 265                 270         


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
        275                 280                 285             


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
    290                 295                 300                 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
305                 310                 315                 320 


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
                325                 330                 335     


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
            340                 345                 350         


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
        355                 360                 365             


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
    370                 375                 380                 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
385                 390                 395                 400 


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
                405                 410                 415     


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
            420                 425                 430         


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
        435                 440                 445             


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
    450                 455                 460                 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
465                 470                 475                 480 


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
                485                 490                 495     


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
            500                 505                 510         


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
        515                 520                 525             


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
    530                 535                 540                 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
545                 550                 555                 560 


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
                565                 570                 575     


Ala Ala 
        


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP2

<400>  6

Pro Leu Gly Leu Ala Gly 
1               5       


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  7

Gly Pro Leu Gly Met Leu Ser Gln 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  8

Gly Pro Leu Gly Leu Trp Ala Gln 
1               5               


<210>  9
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-EGFR VL

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105     


<210>  10
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-EGFR VH

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  11
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse monoclonal SP34(mu) variable heavy chain

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125 


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-EGFR VL chain

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  14
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  15
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  16
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  17
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  18
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  19
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  20
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  21
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  21

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  22
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  22

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  23
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  24
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  24

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  25
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  26
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  27
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  28
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  28

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  29
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  30
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  30

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  31
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  32
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  32

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  33
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  34

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  35
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  36
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  36

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  37
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  38
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  39
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chain

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asp Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  40
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light chain from mouse monoclonal antibody SP34VL(mu)

<400>  40

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  41
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-anti-CD3 epsilon Variable Light chain and  constant light 
       chain

<400>  41

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu 
    210             


<210>  42
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-anti-CD3 epsilon Variable Light chain

<400>  42

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val 
            


<210>  43
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  43

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val 
            


<210>  44
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  44

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val 
            


<210>  45
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  45

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val 
            


<210>  46
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  46

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val 
            


<210>  47
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  47

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Thr 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  48
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  48

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Trp Thr 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  49
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  49

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  50
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  50

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  51
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  51

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  52
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  52

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  53
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  53

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  54
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  54

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  55
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  55

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  56
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  56

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  57
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  57

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  58
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  58

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  59
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  59

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  60
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  60

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  61
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  61

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  62
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  62

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  63
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  63

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  64
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  64

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  65
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  65

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  66
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  66

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  67
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  67

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  68
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  68

Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  69
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  69

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  70
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Variable Light chain

<400>  70

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Lys Ser Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1of anti-CD3 Heavy Chain (CDR-H1)


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  71

Thr Xaa Xaa Tyr Ala Met Asn 
1               5           


<210>  72
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of anti-CD3 Heavy Chain (CDR-H2)

<400>  72

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  73
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of anti-CD3 Heavy Chain (CDR-H3)

<400>  73

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  74
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of anti-CD3 Light Chain (CDR-L1)

<400>  74

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  75
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of anti-CD3 Light Chain (CDR-L1)

<400>  75

Ala Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of anti-CD3 Light Chain (CDR-L1)

<400>  76

Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of anti-CD3 Light Chain (CDR-L2)

<400>  77

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of anti-CD3 Light Chain (CDR-L3)

<400>  78

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of anti-CD3 Light Chain (CDR-L3)

<400>  79

Leu Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  80
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  80

Gly Ser Gly Ser 
1               


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  81

Gly Ser Gly Gly Ser 
1               5   


<210>  82
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  82

Gly Gly Gly Ser 
1               


<210>  83
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  83

Gly Gly Ser Gly 
1               


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  84

Gly Gly Ser Gly Gly 
1               5   


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  85

Gly Ser Gly Ser Gly 
1               5   


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  86

Gly Ser Gly Gly Gly 
1               5   


<210>  87
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  87

Gly Gly Gly Ser Gly 
1               5   


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  88

Gly Ser Ser Ser Gly 
1               5   


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  89

Gly Pro Leu Gly Met Leu Ser Gln 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease site

<400>  90

Gly Pro Leu Gly Leu Trp Ala Gln 
1               5               


<210>  91
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  91

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  92
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  92

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  93

Gly Gly Gly Gly Ser 
1               5   


<210>  94
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-EGFR ScFV VH-linker VL

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln His 
    210                 215                 220                 


Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  95

Gly Gly Gly Ser Gly Gly Ser 
1               5           


<210>  96
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-EGFR ScFV VL-linker VH

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp 
145                 150                 155                 160 


Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile Gly His Ile Tyr 
                165                 170                 175     


Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr 
            180                 185                 190         


Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser Leu Lys Leu Ser Ser 
        195                 200                 205             


Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Val Arg Asp Arg Val 
    210                 215                 220                 


Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  97
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3Epsilon (AA1-27)-GlyGly-hALB-G-PLGLAG-RTGGS-anti-human 
       anti-CD3Epsilon-G1Fd-CPPC-G4S-his6*

<400>  97

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Ser Glu Val 
            20                  25                  30          


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
        35                  40                  45              


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
    50                  55                  60                  


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
65                  70                  75                  80  


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
                85                  90                  95      


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
            100                 105                 110         


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
        115                 120                 125             


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
    130                 135                 140                 


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
145                 150                 155                 160 


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
                165                 170                 175     


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
            180                 185                 190         


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
        195                 200                 205             


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
    210                 215                 220                 


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
225                 230                 235                 240 


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
                245                 250                 255     


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
            260                 265                 270         


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
        275                 280                 285             


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
    290                 295                 300                 


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
305                 310                 315                 320 


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
                325                 330                 335     


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
            340                 345                 350         


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
        355                 360                 365             


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
    370                 375                 380                 


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
385                 390                 395                 400 


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
                405                 410                 415     


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
            420                 425                 430         


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
        435                 440                 445             


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
    450                 455                 460                 


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
465                 470                 475                 480 


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
                485                 490                 495     


Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 
            500                 505                 510         


Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 
        515                 520                 525             


Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 
    530                 535                 540                 


Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 
545                 550                 555                 560 


Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 
                565                 570                 575     


Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 
            580                 585                 590         


Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Gly 
        595                 600                 605             


Pro Leu Gly Leu Ala Gly Arg Thr Gly Gly Ser Glu Val Gln Leu Val 
    610                 615                 620                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
625                 630                 635                 640 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val 
                645                 650                 655     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
            660                 665                 670         


Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg 
        675                 680                 685             


Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met 
    690                 695                 700                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
705                 710                 715                 720 


Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln 
                725                 730                 735     


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
            740                 745                 750         


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
        755                 760                 765             


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
    770                 775                 780                 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
785                 790                 795                 800 


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
                805                 810                 815     


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
            820                 825                 830         


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Pro 
        835                 840                 845             


Pro Cys Gly Gly Gly Gly Ser His His His His His 
    850                 855                 860 


<210>  98
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  98

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  99
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  99

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  100

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP-2 cleavable sequence

<400>  101

Gly Pro Leu Gly Leu Ala Gly 
1               5           


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  non-cleavable sequence

<400>  102

Gly Leu Ser Gly Arg Ser Asp Asn His 
1               5                   


<210>  103
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  extracellular sequence of CD3epsilon

<400>  103

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      


Val Cys Glu Asn Cys Met Glu Met Asp 
            100                 105 


<210>  104
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable sequence

<400>  104

Lys Lys Asn Pro Ala Glu Leu Ile Gly Pro Val Asp 
1               5                   10          


<210>  105
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavable sequence

<400>  105

Lys Lys Gln Pro Ala Ala Asn Leu Val Ala Pro Glu Asp 
1               5                   10              


<210>  106
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3e(AA1-27)-G4Sx3 linker-hALB-G-PLGLAG 
       (MMP2/9)-h1F3.5-G1Fd-CPPC

<400>  106

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Glu Val Ala His Arg Phe Lys Asp Leu 
        35                  40                  45              


Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr 
    50                  55                  60                  


Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val 
65                  70                  75                  80  


Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys 
                85                  90                  95      


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala 
            100                 105                 110         


Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln 
        115                 120                 125             


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
    130                 135                 140                 


Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala 
145                 150                 155                 160 


Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile 
                165                 170                 175     


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 
            180                 185                 190         


Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 
        195                 200                 205             


Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 
    210                 215                 220                 


Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 
225                 230                 235                 240 


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 
                245                 250                 255     


Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 
            260                 265                 270         


Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
        275                 280                 285             


Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 
    290                 295                 300                 


Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 
305                 310                 315                 320 


Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 
                325                 330                 335     


Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 
            340                 345                 350         


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 
        355                 360                 365             


Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala 
    370                 375                 380                 


Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro 
385                 390                 395                 400 


His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu 
                405                 410                 415     


Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu 
            420                 425                 430         


Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys 
        435                 440                 445             


Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu 
    450                 455                 460                 


Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met 
465                 470                 475                 480 


Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val 
                485                 490                 495     


Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr 
            500                 505                 510         


Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp 
        515                 520                 525             


Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His 
    530                 535                 540                 


Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln 
545                 550                 555                 560 


Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu 
                565                 570                 575     


Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys 
            580                 585                 590         


Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys 
        595                 600                 605             


Leu Val Ala Ala Ser Gln Ala Ala Gly Gly Ser Gly Gly Ser Pro Leu 
    610                 615                 620                 


Gly Leu Ala Gly Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                645                 650                 655     


Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
        675                 680                 685             


Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe 
    690                 695                 700                 


Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
705                 710                 715                 720 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly 
                725                 730                 735     


Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly 
            740                 745                 750         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        755                 760                 765             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    770                 775                 780                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
785                 790                 795                 800 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                805                 810                 815     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            820                 825                 830         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        835                 840                 845             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Pro Pro 
    850                 855                 860                 


Cys 
865 


<210>  107
<211>  2595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3e(AA1-27)-G4Sx3 linker-hALB-G-PLGLAG (MMP2/9)-h1F3.5-G1Fd-CPPC

<400>  107
caggacggca acgaggagat gggcggcatc acccagacac catacaaggt gagcatctcc       60

ggcaccacag tgatcctgac cggaggaggc agcggaggag gctccggagg cggctctgag      120

gtggcccaca ggttcaagga tctgggcgag gagaacttca aggccctggt gctgatcgcc      180

ttcgcccagt atctgcagca gtgccccttt gaggaccacg tgaagctggt gaacgaggtg      240

accgagttcg ccaagacatg cgtggccgac gagtccgccg agaattgtga taagtctctg      300

cacaccctgt ttggcgataa gctgtgcacc gtggccacac tgagggagac atacggcgag      360

atggccgact gctgtgccaa gcaggagccc gagcgcaacg agtgcttcct gcagcacaag      420

gacgataacc ctaatctgcc acggctggtg agacctgagg tggacgtgat gtgcaccgcc      480

ttccacgata atgaggagac atttctgaag aagtacctgt atgagatcgc ccggagacac      540

ccttactttt atgccccaga gctgctgttc tttgccaagc ggtacaaggc agccttcacc      600

gagtgctgtc aggcagcaga taaggcagca tgcctgctgc caaagctgga cgagctgagg      660

gatgagggca aggcaagctc cgccaagcag cgcctgaagt gtgcaagcct gcagaagttc      720

ggagagaggg cctttaaggc atgggcagtg gcaaggctgt cccagcggtt cccaaaggcc      780

gagtttgccg aggtgtctaa gctggtgacc gacctgacaa aggtgcacac cgagtgctgt      840

cacggcgacc tgctggagtg cgcagacgat agagccgatc tggccaagta catctgtgag      900

aaccaggact ctatctctag caagctgaag gagtgctgtg agaagcccct gctggagaag      960

tcccactgca tcgccgaggt ggagaacgac gagatgccag cagatctgcc aagcctggca     1020

gcagacttcg tggagtccaa ggacgtgtgc aagaattacg ccgaggccaa ggacgtgttc     1080

ctgggcatgt ttctgtacga gtatgccagg cgccaccctg actactccgt ggtgctgctg     1140

ctgcggctgg ccaagaccta tgagaccaca ctggagaagt gctgtgccgc cgccgacccc     1200

cacgagtgct atgcaaaggt gttcgacgag tttaagcccc tggtggagga gcctcagaac     1260

ctgatcaagc agaattgtga gctgtttgag cagctgggcg agtacaagtt ccagaacgcc     1320

ctgctggtga gatataccaa gaaggtgcca caggtgtcta cccccacact ggtggaggtg     1380

agccggaatc tgggcaaggt cggctccaag tgctgtaagc accctgaggc caagagaatg     1440

ccatgcgccg aggattacct gtccgtggtg ctgaaccagc tgtgcgtgct gcacgagaag     1500

acccccgtga gcgacagggt gaccaagtgc tgtacagagt ctctggtgaa ccggagacca     1560

tgctttagcg ccctggaggt ggatgagaca tatgtgccca aggagttcaa tgccgagacc     1620

ttcacatttc acgccgacat ctgtaccctg agcgagaagg agcgccagat caagaagcag     1680

acagccctgg tggagctggt gaagcacaag ccaaaggcca ccaaggagca gctgaaggcc     1740

gtgatggacg atttcgccgc ctttgtggag aagtgctgta aggccgacga taaggagaca     1800

tgcttcgcag aggagggcaa gaagctggtg gcagcaagcc aggcagcagg aggctccggc     1860

ggctctccac tgggcctggc cggcggcggc agcggcggct ccgaggtgca gctggtggag     1920

tccggcggcg gcctggtgca gcccggcggc agcctgaggc tgtcctgcgc cgcctctggc     1980

ttcaccttta acacatacgc aatgaattgg gtgcgccagg caccaggcaa gggactggag     2040

tgggtggccc ggatcagaag caagtacaac aattatgcca cctactatgc cgactccgtg     2100

aaggatcggt ttaccatcag cagagacgat tccaagaaca cactgtatct gcagatgaat     2160

agcctgcggg ccgaggatac agccgtgtac tattgcgtga gacacggcaa ctttggcaat     2220

tcttacgtga gctggttcgc ctattggggc cagggcacca tggtgacagt gtcctctgcc     2280

tctaccaagg gacctagcgt gttcccactg gcacctagct ccaagtctac cagcggaggc     2340

acagccgccc tgggatgtct ggtgaaggac tactttccag agcccgtgac agtgtcctgg     2400

aactctggcg ccctgaccag cggagtgcac acattccctg ccgtgctgca gtctagcggc     2460

ctgtactccc tgtcctctgt ggtgaccgtg ccaagctcct ctctgggcac ccagacatat     2520

atctgcaacg tgaatcacaa gccctctaat acaaaggtgg acaagagggt ggagcctaag     2580

agctgccccc cttgt                                                      2595


<210>  108
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-cleavable CD3epsilon-G4Sx3 linker-hALB-G-GGSGGS 
       h1F3.5-G1Fd-CPPC

<400>  108

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Glu Val Ala His Arg Phe Lys Asp Leu 
        35                  40                  45              


Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr 
    50                  55                  60                  


Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val 
65                  70                  75                  80  


Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys 
                85                  90                  95      


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala 
            100                 105                 110         


Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln 
        115                 120                 125             


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
    130                 135                 140                 


Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala 
145                 150                 155                 160 


Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile 
                165                 170                 175     


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 
            180                 185                 190         


Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 
        195                 200                 205             


Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 
    210                 215                 220                 


Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 
225                 230                 235                 240 


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 
                245                 250                 255     


Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 
            260                 265                 270         


Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
        275                 280                 285             


Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 
    290                 295                 300                 


Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 
305                 310                 315                 320 


Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 
                325                 330                 335     


Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 
            340                 345                 350         


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 
        355                 360                 365             


Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala 
    370                 375                 380                 


Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro 
385                 390                 395                 400 


His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu 
                405                 410                 415     


Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu 
            420                 425                 430         


Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys 
        435                 440                 445             


Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu 
    450                 455                 460                 


Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met 
465                 470                 475                 480 


Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val 
                485                 490                 495     


Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr 
            500                 505                 510         


Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp 
        515                 520                 525             


Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His 
    530                 535                 540                 


Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln 
545                 550                 555                 560 


Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu 
                565                 570                 575     


Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys 
            580                 585                 590         


Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys 
        595                 600                 605             


Leu Val Ala Ala Ser Gln Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                645                 650                 655     


Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
        675                 680                 685             


Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe 
    690                 695                 700                 


Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
705                 710                 715                 720 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly 
                725                 730                 735     


Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly 
            740                 745                 750         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        755                 760                 765             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    770                 775                 780                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
785                 790                 795                 800 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                805                 810                 815     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            820                 825                 830         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        835                 840                 845             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Pro Pro 
    850                 855                 860                 


Cys 
865 


<210>  109
<211>  2595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Non-cleavable CD3epsilon-G4Sx3 linker-hALB-G-GGSGGS 
       h1F3.5-G1Fd-CPPC

<400>  109
caggacggca acgaggagat gggcggcatc acccagacac catacaaggt gagcatctcc       60

ggcaccacag tgatcctgac cggaggaggc agcggaggag gctccggagg cggctctgag      120

gtggcccaca ggttcaagga tctgggcgag gagaacttca aggccctggt gctgatcgcc      180

ttcgcccagt atctgcagca gtgccccttt gaggaccacg tgaagctggt gaacgaggtg      240

accgagttcg ccaagacatg cgtggccgac gagtccgccg agaattgtga taagtctctg      300

cacaccctgt ttggcgataa gctgtgcacc gtggccacac tgagggagac atacggcgag      360

atggccgact gctgtgccaa gcaggagccc gagcgcaacg agtgcttcct gcagcacaag      420

gacgataacc ctaatctgcc acggctggtg agacctgagg tggacgtgat gtgcaccgcc      480

ttccacgata atgaggagac atttctgaag aagtacctgt atgagatcgc ccggagacac      540

ccttactttt atgccccaga gctgctgttc tttgccaagc ggtacaaggc agccttcacc      600

gagtgctgtc aggcagcaga taaggcagca tgcctgctgc caaagctgga cgagctgagg      660

gatgagggca aggcaagctc cgccaagcag cgcctgaagt gtgcaagcct gcagaagttc      720

ggagagaggg cctttaaggc atgggcagtg gcaaggctgt cccagcggtt cccaaaggcc      780

gagtttgccg aggtgtctaa gctggtgacc gacctgacaa aggtgcacac cgagtgctgt      840

cacggcgacc tgctggagtg cgcagacgat agagccgatc tggccaagta catctgtgag      900

aaccaggact ctatctctag caagctgaag gagtgctgtg agaagcccct gctggagaag      960

tcccactgca tcgccgaggt ggagaacgac gagatgccag cagatctgcc aagcctggca     1020

gcagacttcg tggagtccaa ggacgtgtgc aagaattacg ccgaggccaa ggacgtgttc     1080

ctgggcatgt ttctgtacga gtatgccagg cgccaccctg actactccgt ggtgctgctg     1140

ctgcggctgg ccaagaccta tgagaccaca ctggagaagt gctgtgccgc cgccgacccc     1200

cacgagtgct atgcaaaggt gttcgacgag tttaagcccc tggtggagga gcctcagaac     1260

ctgatcaagc agaattgtga gctgtttgag cagctgggcg agtacaagtt ccagaacgcc     1320

ctgctggtga gatataccaa gaaggtgcca caggtgtcta cccccacact ggtggaggtg     1380

agccggaatc tgggcaaggt cggctccaag tgctgtaagc accctgaggc caagagaatg     1440

ccatgcgccg aggattacct gtccgtggtg ctgaaccagc tgtgcgtgct gcacgagaag     1500

acccccgtga gcgacagggt gaccaagtgc tgtacagagt ctctggtgaa ccggagacca     1560

tgctttagcg ccctggaggt ggatgagaca tatgtgccca aggagttcaa tgccgagacc     1620

ttcacatttc acgccgacat ctgtaccctg agcgagaagg agcgccagat caagaagcag     1680

acagccctgg tggagctggt gaagcacaag ccaaaggcca ccaaggagca gctgaaggcc     1740

gtgatggacg atttcgccgc ctttgtggag aagtgctgta aggccgacga taaggagaca     1800

tgcttcgcag aggagggcaa gaagctggtg gcagcaagcc aggcagcagg aggctccggc     1860

ggctctgggg gcagcggagg tagtggcggc agcggcggct ccgaggtgca gctggtggag     1920

tccggcggcg gcctggtgca gcccggcggc agcctgaggc tgtcctgcgc cgcctctggc     1980

ttcaccttta acacatacgc aatgaattgg gtgcgccagg caccaggcaa gggactggag     2040

tgggtggccc ggatcagaag caagtacaac aattatgcca cctactatgc cgactccgtg     2100

aaggatcggt ttaccatcag cagagacgat tccaagaaca cactgtatct gcagatgaat     2160

agcctgcggg ccgaggatac agccgtgtac tattgcgtga gacacggcaa ctttggcaat     2220

tcttacgtga gctggttcgc ctattggggc cagggcacca tggtgacagt gtcctctgcc     2280

tctaccaagg gacctagcgt gttcccactg gcacctagct ccaagtctac cagcggaggc     2340

acagccgccc tgggatgtct ggtgaaggac tactttccag agcccgtgac agtgtcctgg     2400

aactctggcg ccctgaccag cggagtgcac acattccctg ccgtgctgca gtctagcggc     2460

ctgtactccc tgtcctctgt ggtgaccgtg ccaagctcct ctctgggcac ccagacatat     2520

atctgcaacg tgaatcacaa gccctctaat acaaaggtgg acaagagggt ggagcctaag     2580

agctgccccc cttgt                                                      2595


<210>  110
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h1F3.5-G1Fd-CPPC-G4S

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Pro Pro Cys 
225                 230     


<210>  111
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h1F3.5-G1Fd-CPPC-G4S

<400>  111
gaggtgcagc tggtggagtc cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

tcctgcgccg cctctggctt cacctttaac acatacgcaa tgaattgggt gcgccaggca      120

ccaggcaagg gactggagtg ggtggcccgg atcagaagca agtacaacaa ttatgccacc      180

tactatgccg actccgtgaa ggatcggttt accatcagca gagacgattc caagaacaca      240

ctgtatctgc agatgaatag cctgcgggcc gaggatacag ccgtgtacta ttgcgtgaga      300

cacggcaact ttggcaattc ttacgtgagc tggttcgcct attggggcca gggcaccatg      360

gtgacagtgt cctctgcctc taccaaggga cctagcgtgt tcccactggc acctagctcc      420

aagtctacca gcggaggcac agccgccctg ggatgtctgg tgaaggacta ctttccagag      480

cccgtgacag tgtcctggaa ctctggcgcc ctgaccagcg gagtgcacac attccctgcc      540

gtgctgcagt ctagcggcct gtactccctg tcctctgtgg tgaccgtgcc aagctcctct      600

ctgggcaccc agacatatat ctgcaacgtg aatcacaagc cctctaatac aaaggtggac      660

aagagggtgg agcctaagag ctgcccccct tgt                                   693


<210>  112
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-EGFR (VH-linker-VL)-GG-h1F3.1-LambdaLC-CPPC-S*

<400>  112

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln His 
    210                 215                 220                 


Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu 
                245                 250                 255     


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
            260                 265                 270         


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro 
        275                 280                 285             


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro 
    290                 295                 300                 


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
305                 310                 315                 320 


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                325                 330                 335     


Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu 
            340                 345                 350         


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
        355                 360                 365             


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
    370                 375                 380                 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
385                 390                 395                 400 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
                405                 410                 415     


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
            420                 425                 430         


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
        435                 440                 445             


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Pro Pro Cys Ser 
    450                 455                 460                 


<210>  113
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-EGFR (VH-linker-VL)-GG-h1F3.1-LambdaLC-CPPC-S*

<400>  113
caggtgcagc ttcaagagag cggacccggc ctcgtgaagc ccagcgagac cttgagcctg       60

acctgcactg tgagtggcgg tagcgtgagc agcggcgact attactggac ctggatcagg      120

cagagccctg gcaaggggct ggagtggatc ggccacatct actacagcgg gaacacgaac      180

tacaacccca gcctgaagag caggctgacg atcagcatcg acacgagcaa gacccagttc      240

tcacttaagc tcagcagcgt gaccgccgca gacaccgcca tatactactg cgtgagggac      300

agggtgacgg gcgctttcga catctggggc caaggcacaa tggtcacggt gagctccggt      360

gggggtggca gcgggggagg cggaagcggc ggaggtggct ctgatatcca gatgacccaa      420

agccccagta gcctgtccgc cagtgtagga gatagggtaa ccatcacttg ccaagcgagc      480

caagacatca gcaactacct gaattggtat cagcagaagc ccggcaaagc acccaagctc      540

ctgatctacg acgccagcaa tctggagacc ggcgtgccca gcaggttcag cggatctggt      600

agcggcaccg acttcacctt caccataagt agtctgcagc ccgaggacat cgccacctac      660

ttctgtcagc acttcgatca cctgcccctg gccttcggcg gtgggaccaa ggtggagatc      720

aagggtggag gggggtccca agccgtggta acccaggagc ccagtctgac agtgagccct      780

ggcggtacag tgaccttgac ttgcaggagc agtaccggag ccgtaactac ctcaaactac      840

gccaactggg tgcagcagaa gcccggtcag gcccccaggg gccttattgg tgggactaac      900

aaacgagcac ccggaacccc cgcaaggttc agcggcagcc ttctgggcgg aaaggccgct      960

ctcacattga gcggcgtgca gcccgaggac gaggccgagt actactgcgc cctgtggtac     1020

agcaacctgt gggtgttcgg cggagggacc aagctgaccg tgctgggcca gcccaaagct     1080

gcgccgagcg tgaccctgtt ccccccgtca agcgaggagc tgcaggctaa caaggccacc     1140

ctggtgtgcc tgattagtga cttctacccc ggtgccgtca ccgtggcctg gaaggccgac     1200

agtagcccag ttaaagcggg cgtcgagacc accactccca gcaagcagag caacaacaag     1260

tacgccgcga gcagctacct gagtctgacc cccgagcagt ggaagagcca caggagctac     1320

agctgccagg tgacccacga gggcagcact gtggagaaga ctgtggcccc gaccgagtgc     1380

cccccatgta gc                                                         1392


<210>  114
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-EGFR (VL-linker-VH)-GG-h1F3.1-LambdaLC-CPPC-S*

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp 
145                 150                 155                 160 


Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile Gly His Ile Tyr 
                165                 170                 175     


Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr 
            180                 185                 190         


Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser Leu Lys Leu Ser Ser 
        195                 200                 205             


Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Val Arg Asp Arg Val 
    210                 215                 220                 


Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu 
                245                 250                 255     


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
            260                 265                 270         


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro 
        275                 280                 285             


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro 
    290                 295                 300                 


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
305                 310                 315                 320 


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                325                 330                 335     


Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu 
            340                 345                 350         


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
        355                 360                 365             


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
    370                 375                 380                 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
385                 390                 395                 400 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
                405                 410                 415     


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
            420                 425                 430         


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
        435                 440                 445             


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Pro Pro Cys Ser 
    450                 455                 460                 


<210>  115
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-EGFR (VL-linker-VH)-GG-h1F3.1-LambdaLC-CPPC-S*

<400>  115
gatatccaga tgacccaaag ccccagtagc ctgtccgcca gtgtaggaga tagggtaacc       60

atcacttgcc aagcgagcca agacatcagc aactacctga attggtatca gcagaagccc      120

ggcaaagcac ccaagctcct gatctacgac gccagcaatc tggagaccgg cgtgcccagc      180

aggttcagcg gatctggtag cggcaccgac ttcaccttca ccataagtag tctgcagccc      240

gaggacatcg ccacctactt ctgtcagcac ttcgatcacc tgcccctggc cttcggcggt      300

gggaccaagg tggagatcaa gggtgggggt ggcagcgggg gaggcggaag cggcggaggt      360

ggctctcagg tgcagcttca agagagcgga cccggcctcg tgaagcccag cgagaccttg      420

agcctgacct gcactgtgag tggcggtagc gtgagcagcg gcgactatta ctggacctgg      480

atcaggcaga gccctggcaa ggggctggag tggatcggcc acatctacta cagcgggaac      540

acgaactaca accccagcct gaagagcagg ctgacgatca gcatcgacac gagcaagacc      600

cagttctcac ttaagctcag cagcgtgacc gccgcagaca ccgccatata ctactgcgtg      660

agggacaggg tgacgggcgc tttcgacatc tggggccaag gcacaatggt cacggtgagc      720

tccggtggag gggggtccca agccgtggta acccaggagc ccagtctgac agtgagccct      780

ggcggtacag tgaccttgac ttgcaggagc agtaccggag ccgtaactac ctcaaactac      840

gccaactggg tgcagcagaa gcccggtcag gcccccaggg gccttattgg tgggactaac      900

aaacgagcac ccggaacccc cgcaaggttc agcggcagcc ttctgggcgg aaaggccgct      960

ctcacattga gcggcgtgca gcccgaggac gaggccgagt actactgcgc cctgtggtac     1020

agcaacctgt gggtgttcgg cggagggacc aagctgaccg tgctgggcca gcccaaagct     1080

gcgccgagcg tgaccctgtt ccccccgtca agcgaggagc tgcaggctaa caaggccacc     1140

ctggtgtgcc tgattagtga cttctacccc ggtgccgtca ccgtggcctg gaaggccgac     1200

agtagcccag ttaaagcggg cgtcgagacc accactccca gcaagcagag caacaacaag     1260

tacgccgcga gcagctacct gagtctgacc cccgagcagt ggaagagcca caggagctac     1320

agctgccagg tgacccacga gggcagcact gtggagaaga ctgtggcccc gaccgagtgc     1380

cccccatgta gc                                                         1392


<210>  116
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  116

Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
1               5                   10                  15      


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
            20                  25                  30          


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
        35                  40                  45              


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
    50                  55                  60                  


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
65                  70                  75                  80  


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
                85                  90                  95      


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
            100                 105                 110         


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
        115                 120                 125             


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
    130                 135                 140                 


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
145                 150                 155                 160 


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
                165                 170                 175     


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
            180                 185                 190         


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
        195                 200                 205             


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
    210                 215                 220                 


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
225                 230                 235                 240 


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
                245                 250                 255     


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
            260                 265                 270         


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
        275                 280                 285             


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
    290                 295                 300                 


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
305                 310                 315                 320 


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
                325                 330                 335     


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
            340                 345                 350         


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
        355                 360                 365             


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
    370                 375                 380                 


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
385                 390                 395                 400 


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
                405                 410                 415     


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
            420                 425                 430         


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
        435                 440                 445             


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
    450                 455                 460                 


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
465                 470                 475                 480 


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
                485                 490                 495     


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
            500                 505                 510         


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
        515                 520                 525             


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
    530                 535                 540                 


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
545                 550                 555                 560 


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
                565                 570                 575     


Ala 
    


<210>  117
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAP

<400>  117
caggacggca acgaggagat gggcggcatc acccagacac catacaaggt gagcatctcc       60

ggcaccacag tgatcctgac c                                                 81


<210>  118
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  118
aggaggcagc ggaggaggct ccggaggcgg ctct                                   34


<210>  119
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human serum albumin

<400>  119
gaggtggccc acaggttcaa ggatctgggc gaggagaact tcaaggccct ggtgctgatc       60

gccttcgccc agtatctgca gcagtgcccc tttgaggacc acgtgaagct ggtgaacgag      120

gtgaccgagt tcgccaagac atgcgtggcc gacgagtccg ccgagaattg tgataagtct      180

ctgcacaccc tgtttggcga taagctgtgc accgtggcca cactgaggga gacatacggc      240

gagatggccg actgctgtgc caagcaggag cccgagcgca acgagtgctt cctgcagcac      300

aaggacgata accctaatct gccacggctg gtgagacctg aggtggacgt gatgtgcacc      360

gccttccacg ataatgagga gacatttctg aagaagtacc tgtatgagat cgcccggaga      420

cacccttact tttatgcccc agagctgctg ttctttgcca agcggtacaa ggcagccttc      480

accgagtgct gtcaggcagc agataaggca gcatgcctgc tgccaaagct ggacgagctg      540

agggatgagg gcaaggcaag ctccgccaag cagcgcctga agtgtgcaag cctgcagaag      600

ttcggagaga gggcctttaa ggcatgggca gtggcaaggc tgtcccagcg gttcccaaag      660

gccgagtttg ccgaggtgtc taagctggtg accgacctga caaaggtgca caccgagtgc      720

tgtcacggcg acctgctgga gtgcgcagac gatagagccg atctggccaa gtacatctgt      780

gagaaccagg actctatctc tagcaagctg aaggagtgct gtgagaagcc cctgctggag      840

aagtcccact gcatcgccga ggtggagaac gacgagatgc cagcagatct gccaagcctg      900

gcagcagact tcgtggagtc caaggacgtg tgcaagaatt acgccgaggc caaggacgtg      960

ttcctgggca tgtttctgta cgagtatgcc aggcgccacc ctgactactc cgtggtgctg     1020

ctgctgcggc tggccaagac ctatgagacc acactggaga agtgctgtgc cgccgccgac     1080

ccccacgagt gctatgcaaa ggtgttcgac gagtttaagc ccctggtgga ggagcctcag     1140

aacctgatca agcagaattg tgagctgttt gagcagctgg gcgagtacaa gttccagaac     1200

gccctgctgg tgagatatac caagaaggtg ccacaggtgt ctacccccac actggtggag     1260

gtgagccgga atctgggcaa ggtcggctcc aagtgctgta agcaccctga ggccaagaga     1320

atgccatgcg ccgaggatta cctgtccgtg gtgctgaacc agctgtgcgt gctgcacgag     1380

aagacccccg tgagcgacag ggtgaccaag tgctgtacag agtctctggt gaaccggaga     1440

ccatgcttta gcgccctgga ggtggatgag acatatgtgc ccaaggagtt caatgccgag     1500

accttcacat ttcacgccga catctgtacc ctgagcgaga aggagcgcca gatcaagaag     1560

cagacagccc tggtggagct ggtgaagcac aagccaaagg ccaccaagga gcagctgaag     1620

gccgtgatgg acgatttcgc cgcctttgtg gagaagtgct gtaaggccga cgataaggag     1680

acatgcttcg cagaggaggg caagaagctg gtggcagcaa gccaggcagc a              1731


<210>  120
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  120
ggaggctccg gcggctct                                                     18


<210>  121
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cleavage peptide

<400>  121
ccactgggcc tggccggc                                                     18


<210>  122
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  122
ggcggcagcg gcggctcc                                                     18


<210>  123
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chainand heavy constant region 1

<400>  123
gaggtgcagc tggtggagtc cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

tcctgcgccg cctctggctt cacctttaac acatacgcaa tgaattgggt gcgccaggca      120

ccaggcaagg gactggagtg ggtggcccgg atcagaagca agtacaacaa ttatgccacc      180

tactatgccg actccgtgaa ggatcggttt accatcagca gagacgattc caagaacaca      240

ctgtatctgc agatgaatag cctgcgggcc gaggatacag ccgtgtacta ttgcgtgaga      300

cacggcaact ttggcaattc ttacgtgagc tggttcgcct attggggcca gggcaccatg      360

gtgacagtgt cctctgcctc taccaaggga cctagcgtgt tcccactggc acctagctcc      420

aagtctacca gcggaggcac agccgccctg ggatgtctgg tgaaggacta ctttccagag      480

cccgtgacag tgtcctggaa ctctggcgcc ctgaccagcg gagtgcacac attccctgcc      540

gtgctgcagt ctagcggcct gtactccctg tcctctgtgg tgaccgtgcc aagctcctct      600

ctgggcaccc agacatatat ctgcaacgtg aatcacaagc cctctaatac aaaggtggac      660

aagagggtg                                                              669


<210>  124
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable Heavy chainand heavy constant region 1

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220             


<210>  125
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  non-cleavable linker sequence

<400>  125
gggggcagcg gaggtagt                                                     18


<210>  126
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-EGFR Variable Heavy chain

<400>  126
caggtgcagc ttcaagagag cggacccggc ctcgtgaagc ccagcgagac cttgagcctg       60

acctgcactg tgagtggcgg tagcgtgagc agcggcgact attactggac ctggatcagg      120

cagagccctg gcaaggggct ggagtggatc ggccacatct actacagcgg gaacacgaac      180

tacaacccca gcctgaagag caggctgacg atcagcatcg acacgagcaa gacccagttc      240

tcacttaagc tcagcagcgt gaccgccgca gacaccgcca tatactactg cgtgagggac      300

agggtgacgg gcgctttcga catctggggc caaggcacaa tggtcacggt gagctcc         357


<210>  127
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  127
ggtgggggtg gcagcggggg aggcggaagc ggcggaggtg gctct                       45


<210>  128
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-EGFR Variable light chain

<400>  128
gatatccaga tgacccaaag ccccagtagc ctgtccgcca gtgtaggaga tagggtaacc       60

atcacttgcc aagcgagcca agacatcagc aactacctga attggtatca gcagaagccc      120

ggcaaagcac ccaagctcct gatctacgac gccagcaatc tggagaccgg cgtgcccagc      180

aggttcagcg gatctggtag cggcaccgac ttcaccttca ccataagtag tctgcagccc      240

gaggacatcg ccacctactt ctgtcagcac ttcgatcacc tgcccctggc cttcggcggt      300

gggaccaagg tggagatcaa g                                                321


<210>  129
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  129
ggtggagggg ggtcc                                                        15


<210>  130
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 Variable light chainand light constant region

<400>  130
caagccgtgg taacccagga gcccagtctg acagtgagcc ctggcggtac agtgaccttg       60

acttgcagga gcagtaccgg agccgtaact acctcaaact acgccaactg ggtgcagcag      120

aagcccggtc aggcccccag gggccttatt ggtgggacta acaaacgagc acccggaacc      180

cccgcaaggt tcagcggcag ccttctgggc ggaaaggccg ctctcacatt gagcggcgtg      240

cagcccgagg acgaggccga gtactactgc gccctgtggt acagcaacct gtgggtgttc      300

ggcggaggga ccaagctgac cgtgctgggc cagcccaaag ctgcgccgag cgtgaccctg      360

ttccccccgt caagcgagga gctgcaggct aacaaggcca ccctggtgtg cctgattagt      420

gacttctacc ccggtgccgt caccgtggcc tggaaggccg acagtagccc agttaaagcg      480

ggcgtcgaga ccaccactcc cagcaagcag agcaacaaca agtacgccgc gagcagctac      540

ctgagtctga cccccgagca gtggaagagc cacaggagct acagctgcca ggtgacccac      600

gagggcagca ctgtggagaa gactgtggcc ccgaccgag                             639


<210>  131
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-EGFR ScFv VH-L-VL

<400>  131
caggtgcagc ttcaagagag cggacccggc ctcgtgaagc ccagcgagac cttgagcctg       60

acctgcactg tgagtggcgg tagcgtgagc agcggcgact attactggac ctggatcagg      120

cagagccctg gcaaggggct ggagtggatc ggccacatct actacagcgg gaacacgaac      180

tacaacccca gcctgaagag caggctgacg atcagcatcg acacgagcaa gacccagttc      240

tcacttaagc tcagcagcgt gaccgccgca gacaccgcca tatactactg cgtgagggac      300

agggtgacgg gcgctttcga catctggggc caaggcacaa tggtcacggt gagctccggt      360

gggggtggca gcgggggagg cggaagcggc ggaggtggct ctgatatcca gatgacccaa      420

agccccagta gcctgtccgc cagtgtagga gatagggtaa ccatcacttg ccaagcgagc      480

caagacatca gcaactacct gaattggtat cagcagaagc ccggcaaagc acccaagctc      540

ctgatctacg acgccagcaa tctggagacc ggcgtgccca gcaggttcag cggatctggt      600

agcggcaccg acttcacctt caccataagt agtctgcagc ccgaggacat cgccacctac      660

ttctgtcagc acttcgatca cctgcccctg gccttcggcg gtgggaccaa ggtggagatc      720

aag                                                                    723


<210>  132
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-EGFR ScFv VL-L-VH

<400>  132
gatatccaga tgacccaaag ccccagtagc ctgtccgcca gtgtaggaga tagggtaacc       60

atcacttgcc aagcgagcca agacatcagc aactacctga attggtatca gcagaagccc      120

ggcaaagcac ccaagctcct gatctacgac gccagcaatc tggagaccgg cgtgcccagc      180

aggttcagcg gatctggtag cggcaccgac ttcaccttca ccataagtag tctgcagccc      240

gaggacatcg ccacctactt ctgtcagcac ttcgatcacc tgcccctggc cttcggcggt      300

gggaccaagg tggagatcaa gggtgggggt ggcagcgggg gaggcggaag cggcggaggt      360

ggctctcagg tgcagcttca agagagcgga cccggcctcg tgaagcccag cgagaccttg      420

agcctgacct gcactgtgag tggcggtagc gtgagcagcg gcgactatta ctggacctgg      480

atcaggcaga gccctggcaa ggggctggag tggatcggcc acatctacta cagcgggaac      540

acgaactaca accccagcct gaagagcagg ctgacgatca gcatcgacac gagcaagacc      600

cagttctcac ttaagctcag cagcgtgacc gccgcagaca ccgccatata ctactgcgtg      660

agggacaggg tgacgggcgc tttcgacatc tggggccaag gcacaatggt cacggtgagc      720

tcc                                                                    723


<210>  133
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VH

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  134
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Constant Heavy Chain.

<400>  134

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  135
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon VL

<400>  135

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  136
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 epsilon Constant Light Chain.

<400>  136

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Pro Pro Cys Ser 
            100                 105                 


<210>  137
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-5T4 scFv (VL-linker-VH)

<400>  137

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asp Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe Trp 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Arg Ile Asp Pro Asn Arg Gly Gly Thr Glu Tyr Asn Glu Lys Ala Lys 
            180                 185                 190         


Ser Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Gly Gly Asn Pro Tyr Tyr Pro Met Asp Tyr Trp Gly Gln Gly Thr Thr 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  138
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-5T4 VL

<400>  138

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asp Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  139
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-5T4 VH

<400>  139

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Asn Arg Gly Gly Thr Glu Tyr Asn Glu Lys Ala 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Asn Pro Tyr Tyr Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  140
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-5T4 scFv (VH-linker-VL)

<400>  140

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Asn Arg Gly Gly Thr Glu Tyr Asn Glu Lys Ala 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Asn Pro Tyr Tyr Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile Tyr Arg Ala Asn Arg Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Leu Gln Tyr Asp Asp Phe Pro Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys 
                245 


<210>  141
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 scFv (VL-linker-VH)

<400>  141

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Asn Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala 
    130                 135                 140                 


Gly Asn Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp 
145                 150                 155                 160 


Tyr Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys 
        195                 200                 205             


Met Thr Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
    210                 215                 220                 


Gly Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr 
225                 230                 235                 240 


Leu Val Thr Ile Ser 
                245 


<210>  142
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 VL

<400>  142

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Asn Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  143
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 VH

<400>  143

Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr 
                85                  90                  95      


Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Ile Ser 
        115 


<210>  144
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 scFv (VH-linker-VL)

<400>  144

Gln Ser Val Lys Glu Ser Glu Gly Asp Leu Val Thr Pro Ala Gly Asn 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Ser Asp Ile Asn Asp Tyr Pro 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Tyr 
                85                  90                  95      


Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Ile Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Asp Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu 
    210                 215                 220                 


Gly Gly Val Gly Asn Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  145
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  145

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  146
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multiple protease cleavable linker

<400>  146

Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn His 
1               5                   10              


<210>  147
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5T4 scFv
(VL-linker-VH)

<400>  147
gacatacaga tgacccagtc ccccagctcc ctctcagcct ctgtgggcga cagggtgacc       60

atcacctgca gagcttccca aggcatctcc aactacctgg cctggttcca gcagaagcca      120

ggcaaggctc ctaagagcct gatctacagg gctaaccgtc tgcagtccgg cgtgccctcc      180

aggttctctg ggtccggcag cggcacagac ttcaccctta ccatctcctc cctgcagccc      240

gaggacgtag ccacatatta ctgcctgcag tacgatgact tcccctggac tttcggacag      300

ggcaccaagc tggagataaa gggaggtggt ggctcagggg gtgggggctc cggcggaggg      360

gggtctggcg gtggcgggtc ccaggtgcag ctggttcagt ctggtgctga ggtgaagaag      420

cctggcgcct cagttaaagt gtcatgcaag gcctccggct acaccttcac cagtttctgg      480

atgcactggg tgaggcaggc acccggtcag ggcctggagt ggatgggccg aatcgatccc      540

aaccgtggcg gcactgagta caacgagaag gccaagagca gggtcacaat gaccgccgac      600

aagtccacct caactgctta tatggagctg tcctccttgc gttctgagga cactgccgtg      660

tactactgtg caggcggcaa cccctactac cccatggact attgggggca gggtaccact      720

gtcaccgtgt catct                                                       735


<210>  148
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5T4 scFv
(VH-linker-VL)

<400>  148
caggtgcagc tggttcagtc tggtgctgag gtgaagaagc ctggcgcctc agttaaagtg       60

tcatgcaagg cctccggcta caccttcacc agtttctgga tgcactgggt gaggcaggca      120

cccggtcagg gcctggagtg gatgggccga atcgatccca accgtggcgg cactgagtac      180

aacgagaagg ccaagagcag ggtcacaatg accgccgaca agtccacctc aactgcttat      240

atggagctgt cctccttgcg ttctgaggac actgccgtgt actactgtgc aggcggcaac      300

ccctactacc ccatggacta ttgggggcag ggtaccactg tcaccgtgtc atctggaggt      360

ggtggctcag ggggtggggg ctccggcgga ggggggtctg gcggtggcgg gtccgacata      420

cagatgaccc agtcccccag ctccctctca gcctctgtgg gcgacagggt gaccatcacc      480

tgcagagctt cccaaggcat ctccaactac ctggcctggt tccagcagaa gccaggcaag      540

gctcctaaga gcctgatcta cagggctaac cgtctgcagt ccggcgtgcc ctccaggttc      600

tctgggtccg gcagcggcac agacttcacc cttaccatct cctccctgca gcccgaggac      660

gtagccacat attactgcct gcagtacgat gacttcccct ggactttcgg acagggcacc      720

aagctggaga taaag                                                       735


<210>  149
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR1 scFv
(VL-linker-VH)

<400>  149
gacatccaga tgactcagtc ccccagttcc ctgtccgcct ccgtgggcga cagggtgaca       60

atcaactgcc aggcctcaca gtctatcgac agtaaccttg cctggtatca acagaagccc      120

gggaagcccc ccaagctgct gatctacagg gcctccaatc tggcatccgg cgtgccctcc      180

aggttctccg gttccggctc aggcaccgat tttaccctga ccatatcctc cttgcagccc      240

gaggacgtgg ctacctacta ctgtctgggc ggtgtgggca acgtgtccta caggacctcc      300

tttggtggcg gcaccaaggt ggagatcaag ggcggaggag ggtccggtgg agggggcagt      360

ggtgggggag gatcaggagg tggtggctcc cagagtgtga aggagtccga gggcgacctg      420

gtgacccctg ctggcaatct gaccctcacc tgcaccgctt ccggtagcga catcaacgac      480

taccccatat catgggtgag acaggctccc ggcaagggcc tggagtggat cggcttcatc      540

aatagcggtg ggtccacatg gtacgcaagt tgggtgaagg gcaggttcac catctctcga      600

acctcaacta ccgtcgacct gaaaatgacc tccctgacaa ccgacgacac cgcaacctat      660

ttctgcgcca ggggctactc cacatactat ggcgacttca acatctgggg gccagggacc      720

ctggtcacta tctca                                                       735


<210>  150
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR1 scFv
(VH-linker-VL)

<400>  150
cagagtgtga aggagtccga gggcgacctg gtgacccctg ctggcaatct gaccctcacc       60

tgcaccgctt ccggtagcga catcaacgac taccccatat catgggtgag acaggctccc      120

ggcaagggcc tggagtggat cggcttcatc aatagcggtg ggtccacatg gtacgcaagt      180

tgggtgaagg gcaggttcac catctctcga acctcaacta ccgtcgacct gaaaatgacc      240

tccctgacaa ccgacgacac cgcaacctat ttctgcgcca ggggctactc cacatactat      300

ggcgacttca acatctgggg gccagggacc ctggtcacta tctcaggcgg aggagggtcc      360

ggtggagggg gcagtggtgg gggaggatca ggaggtggtg gctccgacat ccagatgact      420

cagtccccca gttccctgtc cgcctccgtg ggcgacaggg tgacaatcaa ctgccaggcc      480

tcacagtcta tcgacagtaa ccttgcctgg tatcaacaga agcccgggaa gccccccaag      540

ctgctgatct acagggcctc caatctggca tccggcgtgc cctccaggtt ctccggttcc      600

ggctcaggca ccgattttac cctgaccata tcctccttgc agcccgagga cgtggctacc      660

tactactgtc tgggcggtgt gggcaacgtg tcctacagga cctcctttgg tggcggcacc      720

aaggtggaga tcaag                                                       735


