                         SEQUENCE LISTING

<110>  Vrije Universiteit Brussel
 
<120>  LIVER-SPECIFIC NUCLEIC ACID REGULATORY ELEMENTS AND METHODS AND 
       USE THEREOF

<130>  VUB-076-PCT

<150>  18202986.8
<151>  2018-10-26

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  1
tgggaaatta cagttaaata ccatggtaat gaataaaagg tacaaatcgt ttaaactctt       60

atgtaaaatt tgataagatg ttttacacaa ctttaataca ttgacaaggt cttgtggaga      120

aaacagttcc agatggtaaa tatacacaag ggatttagtc aaacaatttt ttggcaagaa      180

tattatgaat tttgtaatcg gttggcagcc aatgaaatac aaagatgagt ctagttaata      240

atctacaatt attggttaaa gaagtatatt agtgctaatt tccctccgtt tgtcctagct      300

tttctcttct gtcaacccca cacgcctttg gcacaa                                336


<210>  2
<211>  347
<212>  DNA
<213>  Homo sapiens

<400>  2
ttttttcttt tctaaatgat cagtacactt attctttcta aagaaaatac ttttcttaac       60

tactctctat ttttaaactt ctcccacaaa gatgagaaaa catttaaaaa tcattggggc      120

tatttttctg tttaccgagt aaagagaatc tctaaaccat atttataact cttactctaa      180

atatttgcat ttaccctcat gccagagccc gttgatgact gactaaacag agtttcaaag      240

tttgaagaac aggaaattta gaaatgacta acaattatgt aggtttattt ctctcagtat      300

agaatgttca tatagaatta atgccagagg ttttcagaga aaaatgc                    347


<210>  3
<211>  386
<212>  DNA
<213>  Homo sapiens

<400>  3
gggacactga agccaaatgg gcttcagctc ctccccaggg atctccctac ctgctgccca       60

ttccaacctg gctctctccc tctccacaac tgaagcccag gcctctttgg atgctgctca      120

cacatcttgc ctccttatct tacctagcca gcgtctctgt ccttggtgtc tgtgcctgcc      180

ctggctggag aggaaggggc tatatacctg tctgtttacc caccccctgt caggtgacag      240

ggactatgga tgggcccagt ggggcaggga ttatgtgagg ataaacaagt tggagaaatg      300

ggggaggaga ggacaagcac atggaagact catggtgatg gggtgagagg cagggggtac      360

agctcttagt ggaggctaag ggggta                                           386


<210>  4
<211>  426
<212>  DNA
<213>  Homo sapiens

<400>  4
gagttaatgt gtaatgagac ggggagaaaa caggagagcc cagaatgacc tggatgctga       60

tcactgaaca taccctaccc ccagtaaaac aaattcagaa aacagcttcc gcccgtcccc      120

tcccaatgga gggctctggc aggaaaagag gtgaataaga ggcttctacc agggtaaagg      180

ttgaaggcac ctggtcattt gatcacctta tcagttctag gcagtgatta gccaatattg      240

agtcagcagg ggcaatagcc ctggcccttg tctcactcct gttgggggtg ggggaggggg      300

agaggtacat tcccaggttc aaagcatttg ggtgaaatca gttaaataga tatcagaagc      360

ttttgtatct ttcacccttt tgccccccaa gcatactcgc tgagtatgtg gaacattcct      420

gagggt                                                                 426


<210>  5
<211>  260
<212>  DNA
<213>  Homo sapiens

<400>  5
tgttttgttt tggtgaccta actggtcaaa tgacctatta agaatatttc atagaacgaa       60

tgttccgatg ctctaatctc tctagacaag gttcatattt gtatgggtta cttattctct      120

ctttgttgac taagtcaata atcagaatca gcaggtttgc agtcagattg gcagggataa      180

gcagcctagc tcaggagaag tgagtataaa agccccaggc tgggagcagc catcacagaa      240

gtccactcat tcttggcagg                                                  260


<210>  6
<211>  267
<212>  DNA
<213>  Homo sapiens

<400>  6
aggggggccc ctggggctga cagggactgg aagctctgag ctggccagag ggatgttgca       60

atcctgccag ggtcttgtct atgctgtcct tttcacaacc atccccctac tgccaggctg      120

acacgtggtt gcgggggcac aaggccagcc aacctagagt ctgaggctag gcggaggaca      180

ccctccccac cagctgccag ggtcactggc ggtcaaaggc agctggtggg gaaggcattg      240

gactccagcc ttgggggacg gatgtag                                          267


<210>  7
<211>  313
<212>  DNA
<213>  Homo sapiens

<400>  7
tacaggcctg gggtcccggc ttagaggacc tctgagagct ccggggcccc ttctgggtcg       60

tggttgcctc atcgtggtcg ggtgggtctc caggttctcc caggctcagt cccgcaggcg      120

ccaaatctgc gcaggagagc actagcaacc gatgacgtat tgaggcccac acctctggga      180

ttggctgtcc tgcttcgaca gccttgaaag tgggtaagct gggtgggggg ctctgggaga      240

ggtcagtgct gagtaaggca attcccagca gcttgagccc caccaggtca ctccagtatt      300

cctccccatt ctt                                                         313


<210>  8
<211>  513
<212>  DNA
<213>  Homo sapiens

<400>  8
cccgaacgaa taaacccctt ccttaactca gcgtctgagg aattttgtct gcggctcctc       60

ctgctacatt ctgagtgggg aaagggacta aggtggtctg aggaccccac agagtcagga      120

agattgagag gtgagagtgc tgaacgggga ggggctttgg ggctaaggga agtgcccggg      180

accccacctg accccaacgc tcacgggaca ggggcagagg agaaaaacgt gggtggacag      240

agggaggcag gcggtcaggg gaaggctcag gaggagggag atcaacatca acctgccccg      300

ccccctcccc agcctgataa aggtcctgcg ggcaggacag gacctcccaa ccaagccctc      360

cagcaaggat tcaggttggt gctgagtgcc tgggagggac acccgcctac actctgcaag      420

aaactcaaaa agggagatga ggggatcgtg ggagggaggt agggagggag gagggtgcca      480

ctgatcccct gaacccctgc ctctgcctcc aga                                   513


<210>  9
<211>  306
<212>  DNA
<213>  Homo sapiens

<400>  9
gatgagtgca gggaaccccg accccacccg ggagacctgc aagcctgcag acactcccct       60

cccgccccca ctgaaccctt gacccctgcc ctgcagcccc cgcagcttgc tgtttgccca      120

ctctatttgc ccagccccag ggacagagct gatccttgaa ctcttaagtt ccacattgcc      180

aggaccagtg agcagcaaca gggccggggc tgggcttatc agcctcccag cccagaccct      240

ggctgcagac ataaataggc cctgcaagag ctggctgctt agagactgcg agaaggaggt      300

gcgtcc                                                                 306


<210>  10
<211>  406
<212>  DNA
<213>  Homo sapiens

<400>  10
ttctatcatt atcttcaatc agaaactgat gtgtggggag gtgatgtatc ataactcatc       60

cagggtcagg cagctggatt tgaacctgcc tgacccttag atttgaggtt ttctggctcc      120

agaatcttct ctgaagtgaa aggcatgagg ccgaccactc cctgatctgg taaacagaga      180

tgtcagcctg gtttctagtg ttagggagtt tcctggagtg atggtacagg gtacatttct      240

gccctgcatc ccaagtccag agactgggtt ctaggtccag cctttcttct aactccctga      300

gagatgacag cctctgggca aagtccctct gtgctcttca gtctcttcat ctgtgagatg      360

gtggcatggg gagaggctgg agtgatgtca cagttcctct cagcct                     406


<210>  11
<211>  504
<212>  DNA
<213>  Homo sapiens

<400>  11
acaaaagctg cagcaaaatt gccaaaagta ggaactactg ggggtggggg tcctgtctcc       60

cctgctcagt caccacctcc cctccctaac tctcattctg gctcatacca cgtgctccca      120

gaagaaacgt tctgagcagg ggctggtatg agactgcctc ccctcccagg acccactcct      180

ccctatgacc aggctggtga ccctccctct agggtgccag tgccattcac tgagcagatg      240

tttggcaggt gtctgttatg tgccagacct agcaggggac agagtcctcc cgatacagat      300

ggaccagtat gtttggacat aaattgtgaa aggagttgct aatctttctg tgcaaaatcc      360

actcttgcgg tcaccgccaa cactcctaca catgtcaggg catccagggc caggacttgg      420

taaccctgtt caggagcagt cgctctggag actcccaaga cgagggaaag aaatgggtgg      480

aaacaggggc ctacactgtg ggcc                                             504


<210>  12
<211>  431
<212>  DNA
<213>  Homo sapiens

<400>  12
gtgaggccac ggtcttcccg ccaggttgac tcgagcctcc tgccagagcc actggccccg       60

gaggccaccc tagaccgcag ctggcggccg ctggcacgag tgcagggtaa ctgagccagg      120

gccgctggcg catttggcct ggccgaggcc accccgcgcg gccgctccac tgtgcccgag      180

gctgtcctgg aggtgaggcc ggcccacagg gaccctgccc gtgcccgggc tccggtgagt      240

cagggcgcgt tatgcaagtg cccccggcgc ctccccttcg gtctttcacc ccgcgcggtt      300

acgaaagcgc gaccccctcc ccccggcgct ataaagcagc ggggcggccg cggcgcgctc      360

gcctccctcg ctccacgcgc gcccggactc ggcggccagg cttgcgcgcg gttcccctcc      420

cggtggtgag t                                                           431


<210>  13
<211>  448
<212>  DNA
<213>  Homo sapiens

<400>  13
aaatacctaa actagtcaca ctgttttgat tcaattggct actgaagtta tagaatgttg       60

tttactcttc tctcctttgt ctactcccca gccaacaaaa caaccgacct tagctgtttt      120

gaaaataaat gaaaattcca acatgggttt gaaataaaat tgcatcataa acaatcggta      180

ggtgtttttc aaagtggttt cagggaagtg ccacggagta agcaggcgac caccgaggct      240

gctaaaatat ttcctgtcct gaccagggtt gcgtttctgg agaatattta acagggaggg      300

ttttaacgct tttaaagatg ttgaaactaa agaacaaata ttgaccagag ggcaccacaa      360

cgctcctgaa agagagtaaa atacatcctt tataaaatga aaaactactt ggatgaatta      420

ttccaaaatt cctgcacaag tggacctc                                         448


<210>  14
<211>  335
<212>  DNA
<213>  Homo sapiens

<400>  14
ctgagctcat ctgggctgca gggctggcgg gacagcagcg tggactcagt ctcctaggga       60

tttcccaact ctcccgcccg cttgctgcat ctggacaccc tgcctcaggc cctcatctcc      120

actggtcagc aggtgacctt tgcccagcgc cctgggtcct cagtgcctgc tgccctggag      180

atgatataaa acaggtcaga accctcctgc ctgtctgctc agttcatccc tagaggcagc      240

tgctccaggt aatgccctct ggggagggga aagaggaggg gaggaggatg aagaggggca      300

agaggagctc cctgcccagc ccagccagca agcct                                 335


<210>  15
<211>  431
<212>  DNA
<213>  Homo sapiens

<400>  15
agaagggtca gcggcccctc ctggaccacc gactccccgc agaactcctc tgtgccctct       60

cctcaccaga ccttgttcct cccagttgct cccacagcca gggggcagtg agggctgctc      120

ttcccccagc cccactgagg aacccaggaa ggtgaacgag agaatcagtc ctggtggggg      180

ctggggaggg ccccagacat gagaccagct cctcccccag gggatgttat cagtgggtcc      240

agagggcaaa atagggagcc tggtggaggg aggggcaaag gcctcgggct ctgagcggcc      300

ttggcccttc tccaccaacc cctgccctac actaaggggg aggcagcggg gggcacacag      360

ggtgggggcg ggtggggggc tgctgggtga gcagcactcg cctgcctgga ttgaaaccca      420

gagatggagg t                                                           431


<210>  16
<211>  559
<212>  DNA
<213>  Homo sapiens

<400>  16
gtagctgatg ggaagagcag actgccttcc agccaggcct ggtcctgtga gtcagggacg       60

tccatcttag tgggcatgaa aggcctgtgt gatctcgagg gagacatcgc ctctccaagc      120

ctctccttat ctgtgcaaca ggcagactta atgattggtg aggcaatgag gctgatagct      180

cagcattagc tacagccacc cctcctggcc aaccacacag ggatcaaacc aggggtcagt      240

ccagaggtca gagtcaggag cagacaactc agatccagcc agggacaggc aggtcacacg      300

gacatgtgcc tcacgtatgc ttcaaggggc cctcccccgg gcagaactga aggacagctc      360

ctgttgccat aggagggagc tgggtgagat actaggagga acttccggca tgatgatgtg      420

tgatgaacaa gggcctctgg ccaacaggtc tgaatcaggg ctgcccagcc cagcctggtg      480

ggaagggcat ggagcatggg ggctcatgta ctaaacctca cctggacaca aggtgaaaca      540

gcccaacccc agaggacca                                                   559


<210>  17
<211>  370
<212>  DNA
<213>  Homo sapiens

<400>  17
gcttgcaaca atgtctggca cataggaaaa gtgatcacta aatgttagcc acgtcttact       60

cctgcaaggc tcacctccct ggaacccatc ggtcccaacc ctgctcctga atcaggcaca      120

gtccagcttg cagcgggagc aaaggtcagt actcagtgcc cctgtccctt ccccaggcca      180

gaggggagga ggagactgag tcacgaatga cacctcagcc gcagtttgac ctccaggact      240

tacagtccta gcagccggtg ccactagcat gtgagaggtc cagaggcgct tctgtctcac      300

ccgcccgcct gggtgcaccc atgctgggag cgcctgcacc atttgagcat gtccgagagc      360

atccaccaga                                                             370


<210>  18
<211>  431
<212>  DNA
<213>  Homo sapiens

<400>  18
ctgggcagga gcagctggct tgagcagaat cttgggacct gaggctctca ggggacctcc       60

cattggggga tggagggcaa tggtggtggt gcccaggagg tcttctactt agatgtctat      120

tggatctcta aatgaggctg catgcataat cacacacaaa catccactga gaaggtgaca      180

caccacgtca gcatgggtcc ctctgccgga ccacaccact cctagtgact atgaggtgac      240

atccaggcac gttgcactat tggctcctgt cggtgagtgc agtgcctgac aacagtgagc      300

tacatttatt tgtaaaaatg aacgccatca gagtagacca caattgtact aactctaatt      360

tgctttgtgt tcattttttc agtttccaga agtggcttaa tgtttcctag ggtcaaaggc      420

agtcaaatga c                                                           431


<210>  19
<211>  481
<212>  DNA
<213>  Homo sapiens

<400>  19
gaagggggaa gagacccact gaaatcctat ctcccagcct cacctctgct gtctcctcca       60

cgcttcctgt ctccagagcc ccgagttcag cataagcaga aagcggcctg ttccctctct      120

agggagagga gggttgcggt ctggaggtct ggctcgtctt tatctgcgca ttctcccagc      180

ctcctggctt cagacctcag cgaggcggcg gctgccggcc ggctctcctc ttcctgcctg      240

cagacctggc ctgctgcttc tttctccttc ctccctccct gcctgccctg cggtttcaaa      300

gtagattaga aataacagtg tcccacatgg aagcctctac ttcttcctgg gtcaactttg      360

atgacgaggc tccagaaaac ctttgcaatg ctgtgtggaa tttttaaatc ggtgagctcg      420

tgctcttgcc ctatttattt gtccagcgta catttctgaa cattgtgaac gtcgaatggg      480

c                                                                      481


<210>  20
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  20
ggaaaacagg gagacagttt cctgtttgag atgttgggag atgcttcgag tagtatattt       60

actggaaata gacattcaac ttggatgtcc ctttttggaa atgtgcctgc gtccagggct      120

gggttggggc cccaatgaac tttggctctg acacagctgt tgccacactc agtggaactg      180

aatctatgtt tgtcttcccc ggcatccttc accccaactc tccccgccac aacatacatc      240

ccatgccagc ctggggaccc tcaaaggtgg cttcatcatt aggtttgtgg ctgggtccca      300

ctgaagtaag tcttggcact cagagggata ggaattgaat gaaga                      345


<210>  21
<211>  386
<212>  DNA
<213>  Homo sapiens

<400>  21
ggaggttgca gtaagccaag attgtgccac tgcactccaa cctgggtgac agagccagac       60

tctgtctcaa gaaaataaag agaaaaagaa ctagattcag gctgtatgtg ggcaccatct      120

acagacatca gacacacaca tttaggagta ataatgatgc aatattgcca aatgtttctc      180

agcaaccatg tgcaactgtt gcatgtactg tttatttcta actcaggagg atctctctaa      240

ccacacattg caagaaaata gactttcagt gtttctggca aaacaaagag tttttttgtt      300

ggcatttatg ctgaaaggga agagttaaaa tgttaatttg tcttttttct tacctccaag      360

ttcactcaaa tcctctcttg aagcag                                           386


<210>  22
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SerpEnh

<400>  22
gggggaggct gctggtgaat attaaccaag gtcaccccag ttatcggagg agcaaacagg       60

ggctaagtcc ac                                                           72


<210>  23
<211>  218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3xSerpEnh

<400>  23
gggggaggct gctggtgaat attaaccaag gtcaccccag ttatcggagg agcaaacagg       60

ggctaagtcc accgggggag gctgctggtg aatattaacc aaggtcaccc cagttatcgg      120

aggagcaaac aggggctaag tccaccgggg gaggctgctg gtgaatatta accaaggtca      180

ccccagttat cggaggagca aacaggggct aagtccac                              218


<210>  24
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TTRe

<400>  24
cactgggagg atgttgagta agatggaaaa ctactgatga cccttgcaga gacagagtat       60

taggacatgt ttgaacaggg gccgggcgat cagcaggtag                            100


<210>  25
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  co-FIX-R338L

<400>  25
atgcagcgcg tgaacatgat catggccgag agccccggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgagcgccga gtgcaccgtg ttcctggacc acgagaacgc caacaagatc      120

ctgaaccgcc ccaagcgcta caacagcggc aagctggagg agttcgtgca gggcaacctg      180

gagcgcgagt gcatggagga gaagtgcagc ttcgaggagg cccgcgaggt gttcgagaac      240

accgagcgca ccaccgagtt ctggaagcag tacgtggacg gcgaccagtg cgagagcaac      300

ccctgcctga acggcggcag ctgcaaggac gacatcaaca gctacgagtg ctggtgcccc      360

ttcggcttcg agggcaagaa ctgcgagctg gacgtgacct gcaacatcaa gaacggccgc      420

tgcgagcagt tctgcaagaa cagcgccgac aacaaggtgg tgtgcagctg caccgagggc      480

taccgcctgg ccgagaacca gaagagctgc gagcccgccg tgcccttccc ctgcggccgc      540

gtgagcgtga gccagaccag caagctgacc cgcgccgagg ccgtgttccc cgacgtggac      600

tacgtgaaca gcaccgaggc cgagaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaacgact tcacccgcgt ggtgggcggc gaggacgcca agcccggcca gttcccctgg      720

caggtggtgc tgaacggcaa ggtggacgcc ttctgcggcg gcagcatcgt gaacgagaag      780

tggatcgtga ccgccgccca ctgcgtggag accggcgtga agatcaccgt ggtggccggc      840

gagcacaaca tcgaggagac cgagcacacc gagcagaagc gcaacgtgat ccgcatcatc      900

ccccaccaca actacaacgc cgccatcaac aagtacaacc acgacatcgc cctgctggag      960

ctggacgagc ccctggtgct gaacagctac gtgaccccca tctgcatcgc cgacaaggag     1020

tacaccaaca tcttcctgaa gttcggcagc ggctacgtga gcggctgggg ccgcgtgttc     1080

cacaagggcc gcagcgccct ggtgctgcag tacctgcgcg tgcccctggt ggaccgcgcc     1140

acctgcctgc tgagcaccaa gttcaccatc tacaacaaca tgttctgcgc cggcttccac     1200

gagggcggcc gcgacagctg ccagggcgac agcggcggcc cccacgtgac cgaggtggag     1260

ggcaccagct tcctgaccgg catcatcagc tggggcgagg agtgcgccat gaagggcaag     1320

tacggcatct acaccaaggt gagccgctac gtgaactgga tcaaggagaa gaccaagctg     1380

acctaatga                                                             1389


<210>  26
<211>  4377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  co-FVIIIdeltaB

<400>  26
atgcagatcg agctgtccac ctgctttttt ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggag ctgtcctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc ccggttcccc cccagagtgc ccaagagctt ccccttcaac      180

accagcgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gccagccacc ccgtgagcct gcacgccgtg      360

ggcgtgagct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagcgg      420

gagaaagaag atgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tgaaggacct gaacagcggc ctgatcggcg ctctgctcgt ctgccgggag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcccaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggcc tgattggctg ccaccggaag agcgtgtact ggcacgtgat cggcatgggc      840

accacacccg aggtgcacag catctttctg gaagggcaca cctttctggt ccggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagctctc accagcacga cggcatggaa     1020

gcctacgtga aggtggactc ttgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcggttcgac     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccccct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga cattcaagac ccgggaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacacactg     1440

ctgatcatct tcaagaacca ggctagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag caggcggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga ggacggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggacctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaacatc cagcggtttc tgcccaaccc tgccggcgtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgactctc tgcagctctc cgtgtgtctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggacaccct gaccctgttc cctttcagcg gcgagacagt gttcatgagc     2100

atggaaaacc ccggcctgtg gattctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg tccaagaaca acgccatcga accccggagc     2280

ttcagccaga acccccccgt gctgacgcgt caccagcggg agatcacccg gacaaccctg     2340

cagtccgacc aggaagagat cgattacgac gacaccatca gcgtggagat gaagaaagag     2400

gatttcgata tctacgacga ggacgagaac cagagcccca gaagcttcca gaagaaaacc     2460

cggcactact tcattgccgc cgtggagagg ctgtgggact acggcatgag ttctagcccc     2520

cacgtgctgc ggaaccgggc ccagagcggc agcgtgcccc agttcaagaa agtggtgttc     2580

caggaattca cagacggcag cttcacccag cctctgtata gaggcgagct gaacgagcac     2640

ctggggctgc tggggcccta catcagggcc gaagtggagg acaacatcat ggtgaccttc     2700

cggaatcagg ccagcagacc ctactccttc tacagcagcc tgatcagcta cgaagaggac     2760

cagcggcagg gcgccgaacc ccggaagaac ttcgtgaagc ccaacgaaac caagacctac     2820

ttctggaaag tgcagcacca catggccccc accaaggacg agttcgactg caaggcctgg     2880

gcctacttca gcgacgtgga tctggaaaag gacgtgcact ctggactgat tggcccactc     2940

ctggtctgcc acactaacac cctcaacccc gcccacggcc gccaggtgac cgtgcaggaa     3000

ttcgccctgt tcttcaccat cttcgacgag acaaagtcct ggtacttcac cgagaatatg     3060

gaacggaact gcagagcccc ctgcaacatc cagatggaag atcctacctt caaagagaac     3120

taccggttcc acgccatcaa cggctacatc atggacaccc tgcctggcct ggtgatggcc     3180

caggaccaga gaatccggtg gtatctgctg tccatgggca gcaacgagaa tatccacagc     3240

atccacttca gcggccacgt gttcaccgtg cggaagaaag aagagtacaa gatggccctg     3300

tacaacctgt accccggcgt gttcgagaca gtggagatgc tgcccagcaa ggccggcatc     3360

tggcgggtgg agtgtctgat cggcgagcac ctgcacgctg gcatgagcac cctgtttctg     3420

gtgtacagca acaagtgcca gaccccactg ggcatggcct ctggccacat ccgggacttc     3480

cagatcaccg cctccggcca gtacggccag tgggccccca agctggccag actgcactac     3540

agcggcagca tcaacgcctg gtccaccaaa gagcccttca gctggatcaa ggtggacctg     3600

ctggccccta tgatcatcca cggcattaag acccagggcg ccaggcagaa gttcagcagc     3660

ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac     3720

cggggcaaca gcaccggcac cctgatggtg ttcttcggca atgtggacag cagcggcatc     3780

aagcacaaca tcttcaaccc ccccatcatt gcccggtaca tccggctgca ccccacccac     3840

tacagcatta gatccacact gagaatggaa ctgatgggct gcgacctgaa ctcctgcagc     3900

atgcctctgg gcatggaaag caaggccatc agcgacgccc agatcacagc cagcagctac     3960

ttcaccaaca tgttcgccac ctggtccccc tccaaggcca ggctgcacct gcagggccgg     4020

tccaacgcct ggcggcctca ggtcaacaac cccaaagaat ggctgcaggt ggactttcag     4080

aaaaccatga aggtgaccgg cgtgaccacc cagggcgtga aaagcctgct gaccagcatg     4140

tacgtgaaag agtttctgat cagcagctct caggatggcc accagtggac cctgttcttt     4200

cagaacggca aggtgaaagt gttccagggc aaccaggact ccttcacccc cgtggtgaac     4260

tccctggacc cccccctgct gacccgctac ctgagaatcc acccccagtc ttgggtgcac     4320

cagatcgccc tcaggatgga agtcctggga tgtgaggccc aggatctgta ctgatga        4377


<210>  27
<211>  202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TTRm

<400>  27
gtctgtctgc acatttcgta gagcgagtgt tccgatactc taatctccct aggcaaggtt       60

catatttgtg taggttactt attctccttt tgttgactaa gtcaataatc agaatcagca      120

ggtttggagt cagcttggca gggatcagca gcctgggttg gaaggagggg gtataaaagc      180

cccttcacca ggagaagccg tc                                               202


<210>  28
<211>  317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TTRe-TTRm

<400>  28
cactgggagg atgttgagta agatggaaaa ctactgatga cccttgcaga gacagagtat       60

taggacatgt ttgaacaggg gccgggcgat cagcaggtag ctctagagga tccccgtctg      120

tctgcacatt tcgtagagcg agtgttccga tactctaatc tccctaggca aggttcatat      180

ttgtgtaggt tacttattct ccttttgttg actaagtcaa taatcagaat cagcaggttt      240

ggagtcagct tggcagggat cagcagcctg ggttggaagg agggggtata aaagcccctt      300

caccaggaga agccgtc                                                     317


<210>  29
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MVM intron

<400>  29
aagaggtaag ggtttaaggg atggttggtt ggtggggtat taatgtttaa ttacctggag       60

cacctgcctg aaatcacttt ttttcaggtt gg                                     92


<210>  30
<211>  295
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGHpolyA

<400>  30
gatctgagcc gaattcctgc agcccggggg atcagcctcg actgtgcctt ctagttgcca       60

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac      120

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat      180

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca      240

tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct gggga           295


<210>  31
<211>  6228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAVsc-TTRe-TTRm-MVM-co-FIX-R338L-BGHpA

<400>  31
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattcaa ttcacgcgtg gtacggccgc     1080

ggtacccact gggaggatgt tgagtaagat ggaaaactac tgatgaccct tgcagagaca     1140

gagtattagg acatgtttga acaggggccg ggcgatcagc aggtagctct agaggatccc     1200

cgtctgtctg cacatttcgt agagcgagtg ttccgatact ctaatctccc taggcaaggt     1260

tcatatttgt gtaggttact tattctcctt ttgttgacta agtcaataat cagaatcagc     1320

aggtttggag tcagcttggc agggatcagc agcctgggtt ggaaggaggg ggtataaaag     1380

ccccttcacc aggagaagcc gtcacacaga tccacaagct cctggctaga aagaggtaag     1440

ggtttaaggg atggttggtt ggtggggtat taatgtttaa ttacctggag cacctgcctg     1500

aaatcacttt ttttcaggtt gggctagccc accatgcagc gcgtgaacat gatcatggcc     1560

gagagccccg gcctgatcac catctgcctg ctgggctacc tgctgagcgc cgagtgcacc     1620

gtgttcctgg accacgagaa cgccaacaag atcctgaacc gccccaagcg ctacaacagc     1680

ggcaagctgg aggagttcgt gcagggcaac ctggagcgcg agtgcatgga ggagaagtgc     1740

agcttcgagg aggcccgcga ggtgttcgag aacaccgagc gcaccaccga gttctggaag     1800

cagtacgtgg acggcgacca gtgcgagagc aacccctgcc tgaacggcgg cagctgcaag     1860

gacgacatca acagctacga gtgctggtgc cccttcggct tcgagggcaa gaactgcgag     1920

ctggacgtga cctgcaacat caagaacggc cgctgcgagc agttctgcaa gaacagcgcc     1980

gacaacaagg tggtgtgcag ctgcaccgag ggctaccgcc tggccgagaa ccagaagagc     2040

tgcgagcccg ccgtgccctt cccctgcggc cgcgtgagcg tgagccagac cagcaagctg     2100

acccgcgccg aggccgtgtt ccccgacgtg gactacgtga acagcaccga ggccgagacc     2160

atcctggaca acatcaccca gagcacccag agcttcaacg acttcacccg cgtggtgggc     2220

ggcgaggacg ccaagcccgg ccagttcccc tggcaggtgg tgctgaacgg caaggtggac     2280

gccttctgcg gcggcagcat cgtgaacgag aagtggatcg tgaccgccgc ccactgcgtg     2340

gagaccggcg tgaagatcac cgtggtggcc ggcgagcaca acatcgagga gaccgagcac     2400

accgagcaga agcgcaacgt gatccgcatc atcccccacc acaactacaa cgccgccatc     2460

aacaagtaca accacgacat cgccctgctg gagctggacg agcccctggt gctgaacagc     2520

tacgtgaccc ccatctgcat cgccgacaag gagtacacca acatcttcct gaagttcggc     2580

agcggctacg tgagcggctg gggccgcgtg ttccacaagg gccgcagcgc cctggtgctg     2640

cagtacctgc gcgtgcccct ggtggaccgc gccacctgcc tgctgagcac caagttcacc     2700

atctacaaca acatgttctg cgccggcttc cacgagggcg gccgcgacag ctgccagggc     2760

gacagcggcg gcccccacgt gaccgaggtg gagggcacca gcttcctgac cggcatcatc     2820

agctggggcg aggagtgcgc catgaagggc aagtacggca tctacaccaa ggtgagccgc     2880

tacgtgaact ggatcaagga gaagaccaag ctgacctaat gaaagatgga tttccaaggt     2940

taattcattg gaattgaaaa ttaacagccc cccccccccc ccccctgcag atctgagccg     3000

aattcctgca gcccggggga tcagcctcga ctgtgccttc tagttgccag ccatctgttg     3060

tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct     3120

aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg     3180

gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg     3240

cggtgggctc tatggcttct gaggcggaaa gaaccagctg gggaccggtg gatctcgata     3300

gcaggcatgc tggggagaga tcgatctgag gaacccctag tgatggagtt ggccactccc     3360

tctctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc     3420

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caaccccccc     3480

cccccccccc cccggcgatt ctcttgtttg ctccagactc tcaggcaatg acctgatagc     3540

ctttgtagag acctctcaaa aatagctacc ctctccggca tgaatttatc agctagaacg     3600

gttgaatatc atattgatgg tgatttgact gtctccggcc tttctcaccc gtttgaatct     3660

ttacctacac attactcagg cattgcattt aaaatatatg agggttctaa aaatttttat     3720

ccttgcgttg aaataaaggc ttctcccgca aaagtattac agggtcataa tgtttttggt     3780

acaaccgatt tagctttatg ctctgaggct ttattgctta attttgctaa ttctttgcct     3840

tgcctgtatg atttattgga tgttggaatc gcctgatgcg gtattttctc cttacgcatc     3900

tgtgcggtat ttcacaccgc atatggtgca ctctcagtac aatctgctct gatgccgcat     3960

agttatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg     4020

acacccgcca acacagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg     4080

cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt     4140

gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc     4200

tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc     4260

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     4320

cgctcatgag acaataaccc tgataaatgc tcaataatat tgaaaaagga agagtatgag     4380

tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt     4440

tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt     4500

gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga     4560

acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat     4620

tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga     4680

gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag     4740

tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg     4800

accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg     4860

ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt     4920

agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg     4980

gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc     5040

ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg     5100

tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac     5160

ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact     5220

gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa     5280

acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa     5340

aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg     5400

atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc     5460

gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac     5520

tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca     5580

ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt     5640

ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc     5700

ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg     5760

aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc     5820

cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac     5880

gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct     5940

ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc     6000

cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt     6060

tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac     6120

cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg     6180

cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatg                  6228


<210>  32
<211>  6448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAVsc-3xSerpEnh-TTRe-TTRm-MVM-co-FIX-R338L-BGHpA

<400>  32
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattcaa ttcacgcgtg gtacggccgc     1080

gggggggagg ctgctggtga atattaacca aggtcacccc agttatcgga ggagcaaaca     1140

ggggctaagt ccaccggggg aggctgctgg tgaatattaa ccaaggtcac cccagttatc     1200

ggaggagcaa acaggggcta agtccaccgg gggaggctgc tggtgaatat taaccaaggt     1260

caccccagtt atcggaggag caaacagggg ctaagtccac ggtacccact gggaggatgt     1320

tgagtaagat ggaaaactac tgatgaccct tgcagagaca gagtattagg acatgtttga     1380

acaggggccg ggcgatcagc aggtagctct agaggatccc cgtctgtctg cacatttcgt     1440

agagcgagtg ttccgatact ctaatctccc taggcaaggt tcatatttgt gtaggttact     1500

tattctcctt ttgttgacta agtcaataat cagaatcagc aggtttggag tcagcttggc     1560

agggatcagc agcctgggtt ggaaggaggg ggtataaaag ccccttcacc aggagaagcc     1620

gtcacacaga tccacaagct cctggctaga aagaggtaag ggtttaaggg atggttggtt     1680

ggtggggtat taatgtttaa ttacctggag cacctgcctg aaatcacttt ttttcaggtt     1740

gggctagccc accatgcagc gcgtgaacat gatcatggcc gagagccccg gcctgatcac     1800

catctgcctg ctgggctacc tgctgagcgc cgagtgcacc gtgttcctgg accacgagaa     1860

cgccaacaag atcctgaacc gccccaagcg ctacaacagc ggcaagctgg aggagttcgt     1920

gcagggcaac ctggagcgcg agtgcatgga ggagaagtgc agcttcgagg aggcccgcga     1980

ggtgttcgag aacaccgagc gcaccaccga gttctggaag cagtacgtgg acggcgacca     2040

gtgcgagagc aacccctgcc tgaacggcgg cagctgcaag gacgacatca acagctacga     2100

gtgctggtgc cccttcggct tcgagggcaa gaactgcgag ctggacgtga cctgcaacat     2160

caagaacggc cgctgcgagc agttctgcaa gaacagcgcc gacaacaagg tggtgtgcag     2220

ctgcaccgag ggctaccgcc tggccgagaa ccagaagagc tgcgagcccg ccgtgccctt     2280

cccctgcggc cgcgtgagcg tgagccagac cagcaagctg acccgcgccg aggccgtgtt     2340

ccccgacgtg gactacgtga acagcaccga ggccgagacc atcctggaca acatcaccca     2400

gagcacccag agcttcaacg acttcacccg cgtggtgggc ggcgaggacg ccaagcccgg     2460

ccagttcccc tggcaggtgg tgctgaacgg caaggtggac gccttctgcg gcggcagcat     2520

cgtgaacgag aagtggatcg tgaccgccgc ccactgcgtg gagaccggcg tgaagatcac     2580

cgtggtggcc ggcgagcaca acatcgagga gaccgagcac accgagcaga agcgcaacgt     2640

gatccgcatc atcccccacc acaactacaa cgccgccatc aacaagtaca accacgacat     2700

cgccctgctg gagctggacg agcccctggt gctgaacagc tacgtgaccc ccatctgcat     2760

cgccgacaag gagtacacca acatcttcct gaagttcggc agcggctacg tgagcggctg     2820

gggccgcgtg ttccacaagg gccgcagcgc cctggtgctg cagtacctgc gcgtgcccct     2880

ggtggaccgc gccacctgcc tgctgagcac caagttcacc atctacaaca acatgttctg     2940

cgccggcttc cacgagggcg gccgcgacag ctgccagggc gacagcggcg gcccccacgt     3000

gaccgaggtg gagggcacca gcttcctgac cggcatcatc agctggggcg aggagtgcgc     3060

catgaagggc aagtacggca tctacaccaa ggtgagccgc tacgtgaact ggatcaagga     3120

gaagaccaag ctgacctaat gaaagatgga tttccaaggt taattcattg gaattgaaaa     3180

ttaacagccc cccccccccc ccccctgcag atctgagccg aattcctgca gcccggggga     3240

tcagcctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct     3300

tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca     3360

tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag     3420

ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct     3480

gaggcggaaa gaaccagctg gggaccggtg gatctcgata gcaggcatgc tggggagaga     3540

tcgatctgag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     3600

cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt     3660

gagcgagcga gcgcgcagag agggagtggc caaccccccc cccccccccc cccggcgatt     3720

ctcttgtttg ctccagactc tcaggcaatg acctgatagc ctttgtagag acctctcaaa     3780

aatagctacc ctctccggca tgaatttatc agctagaacg gttgaatatc atattgatgg     3840

tgatttgact gtctccggcc tttctcaccc gtttgaatct ttacctacac attactcagg     3900

cattgcattt aaaatatatg agggttctaa aaatttttat ccttgcgttg aaataaaggc     3960

ttctcccgca aaagtattac agggtcataa tgtttttggt acaaccgatt tagctttatg     4020

ctctgaggct ttattgctta attttgctaa ttctttgcct tgcctgtatg atttattgga     4080

tgttggaatc gcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc     4140

atatggtgca ctctcagtac aatctgctct gatgccgcat agttatatgg tgcactctca     4200

gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca acacagccag     4260

ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc     4320

gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca     4380

tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc     4440

atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc     4500

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc     4560

tgataaatgc tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg     4620

cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg     4680

tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc     4740

tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca     4800

cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac     4860

tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa     4920

agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg     4980

ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt     5040

ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg     5100

aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc     5160

gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga     5220

tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta     5280

ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc     5340

cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg     5400

atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt     5460

cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa     5520

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt     5580

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     5640

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     5700

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     5760

taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     5820

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     5880

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     5940

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     6000

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     6060

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     6120

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt     6180

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac     6240

ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt     6300

ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga     6360

ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc     6420

tccccgcgcg ttggccgatt cattaatg                                        6448


<210>  33
<211>  6566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE1-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  33
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggtgggaaat tacagttaaa taccatggta atgaataaaa ggtacaaatc gtttaaactc     1140

ttatgtaaaa tttgataaga tgttttacac aactttaata cattgacaag gtcttgtgga     1200

gaaaacagtt ccagatggta aatatacaca agggatttag tcaaacaatt ttttggcaag     1260

aatattatga attttgtaat cggttggcag ccaatgaaat acaaagatga gtctagttaa     1320

taatctacaa ttattggtta aagaagtata ttagtgctaa tttccctccg tttgtcctag     1380

cttttctctt ctgtcaaccc cacacgcctt tggcacaagg tacccactgg gaggatgttg     1440

agtaagatgg aaaactactg atgacccttg cagagacaga gtattaggac atgtttgaac     1500

aggggccggg cgatcagcag gtagctctag aggatccccg tctgtctgca catttcgtag     1560

agcgagtgtt ccgatactct aatctcccta ggcaaggttc atatttgtgt aggttactta     1620

ttctcctttt gttgactaag tcaataatca gaatcagcag gtttggagtc agcttggcag     1680

ggatcagcag cctgggttgg aaggaggggg tataaaagcc ccttcaccag gagaagccgt     1740

cacacagatc cacaagctcc tggctagaaa gaggtaaggg tttaagggat ggttggttgg     1800

tggggtatta atgtttaatt acctggagca cctgcctgaa atcacttttt ttcaggttgg     1860

gctagcccac catgcagcgc gtgaacatga tcatggccga gagccccggc ctgatcacca     1920

tctgcctgct gggctacctg ctgagcgccg agtgcaccgt gttcctggac cacgagaacg     1980

ccaacaagat cctgaaccgc cccaagcgct acaacagcgg caagctggag gagttcgtgc     2040

agggcaacct ggagcgcgag tgcatggagg agaagtgcag cttcgaggag gcccgcgagg     2100

tgttcgagaa caccgagcgc accaccgagt tctggaagca gtacgtggac ggcgaccagt     2160

gcgagagcaa cccctgcctg aacggcggca gctgcaagga cgacatcaac agctacgagt     2220

gctggtgccc cttcggcttc gagggcaaga actgcgagct ggacgtgacc tgcaacatca     2280

agaacggccg ctgcgagcag ttctgcaaga acagcgccga caacaaggtg gtgtgcagct     2340

gcaccgaggg ctaccgcctg gccgagaacc agaagagctg cgagcccgcc gtgcccttcc     2400

cctgcggccg cgtgagcgtg agccagacca gcaagctgac ccgcgccgag gccgtgttcc     2460

ccgacgtgga ctacgtgaac agcaccgagg ccgagaccat cctggacaac atcacccaga     2520

gcacccagag cttcaacgac ttcacccgcg tggtgggcgg cgaggacgcc aagcccggcc     2580

agttcccctg gcaggtggtg ctgaacggca aggtggacgc cttctgcggc ggcagcatcg     2640

tgaacgagaa gtggatcgtg accgccgccc actgcgtgga gaccggcgtg aagatcaccg     2700

tggtggccgg cgagcacaac atcgaggaga ccgagcacac cgagcagaag cgcaacgtga     2760

tccgcatcat cccccaccac aactacaacg ccgccatcaa caagtacaac cacgacatcg     2820

ccctgctgga gctggacgag cccctggtgc tgaacagcta cgtgaccccc atctgcatcg     2880

ccgacaagga gtacaccaac atcttcctga agttcggcag cggctacgtg agcggctggg     2940

gccgcgtgtt ccacaagggc cgcagcgccc tggtgctgca gtacctgcgc gtgcccctgg     3000

tggaccgcgc cacctgcctg ctgagcacca agttcaccat ctacaacaac atgttctgcg     3060

ccggcttcca cgagggcggc cgcgacagct gccagggcga cagcggcggc ccccacgtga     3120

ccgaggtgga gggcaccagc ttcctgaccg gcatcatcag ctggggcgag gagtgcgcca     3180

tgaagggcaa gtacggcatc tacaccaagg tgagccgcta cgtgaactgg atcaaggaga     3240

agaccaagct gacctaatga aagatggatt tccaaggtta attcattgga attgaaaatt     3300

aacagccccc cccccccccc ccctgcagat ctgagccgaa ttcctgcagc ccgggggatc     3360

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     3420

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3480

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3540

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga     3600

ggcggaaaga accagctggg gaccggtgga tctcgatagc aggcatgctg gggagagatc     3660

gatctgagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     3720

ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga     3780

gcgagcgagc gcgcagagag ggagtggcca accccccccc cccccccccc cggcgattct     3840

cttgtttgct ccagactctc aggcaatgac ctgatagcct ttgtagagac ctctcaaaaa     3900

tagctaccct ctccggcatg aatttatcag ctagaacggt tgaatatcat attgatggtg     3960

atttgactgt ctccggcctt tctcacccgt ttgaatcttt acctacacat tactcaggca     4020

ttgcatttaa aatatatgag ggttctaaaa atttttatcc ttgcgttgaa ataaaggctt     4080

ctcccgcaaa agtattacag ggtcataatg tttttggtac aaccgattta gctttatgct     4140

ctgaggcttt attgcttaat tttgctaatt ctttgccttg cctgtatgat ttattggatg     4200

ttggaatcgc ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat     4260

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttatatggtg cactctcagt     4320

acaatctgct ctgatgccgc atagttaagc cagccccgac acccgccaac acagccagcc     4380

ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc     4440

ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc     4500

accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat     4560

gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc     4620

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg     4680

ataaatgctc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     4740

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     4800

aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc     4860

aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact     4920

tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc     4980

ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag     5040

catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat     5100

aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt     5160

ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa     5220

gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc     5280

aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg     5340

gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt     5400

gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca     5460

gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat     5520

gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca     5580

gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg     5640

atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg     5700

ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt     5760

ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg     5820

ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata     5880

ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca     5940

ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag     6000

tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc     6060

tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga     6120

tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg     6180

tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac     6240

gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg     6300

tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg     6360

ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct     6420

gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc     6480

gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc     6540

cccgcgcgtt ggccgattca ttaatg                                          6566


<210>  34
<211>  6577
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE2-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  34
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggttttttct tttctaaatg atcagtacac ttattctttc taaagaaaat acttttctta     1140

actactctct atttttaaac ttctcccaca aagatgagaa aacatttaaa aatcattggg     1200

gctatttttc tgtttaccga gtaaagagaa tctctaaacc atatttataa ctcttactct     1260

aaatatttgc atttaccctc atgccagagc ccgttgatga ctgactaaac agagtttcaa     1320

agtttgaaga acaggaaatt tagaaatgac taacaattat gtaggtttat ttctctcagt     1380

atagaatgtt catatagaat taatgccaga ggttttcaga gaaaaatgcg gtacccactg     1440

ggaggatgtt gagtaagatg gaaaactact gatgaccctt gcagagacag agtattagga     1500

catgtttgaa caggggccgg gcgatcagca ggtagctcta gaggatcccc gtctgtctgc     1560

acatttcgta gagcgagtgt tccgatactc taatctccct aggcaaggtt catatttgtg     1620

taggttactt attctccttt tgttgactaa gtcaataatc agaatcagca ggtttggagt     1680

cagcttggca gggatcagca gcctgggttg gaaggagggg gtataaaagc cccttcacca     1740

ggagaagccg tcacacagat ccacaagctc ctggctagaa agaggtaagg gtttaaggga     1800

tggttggttg gtggggtatt aatgtttaat tacctggagc acctgcctga aatcactttt     1860

tttcaggttg ggctagccca ccatgcagcg cgtgaacatg atcatggccg agagccccgg     1920

cctgatcacc atctgcctgc tgggctacct gctgagcgcc gagtgcaccg tgttcctgga     1980

ccacgagaac gccaacaaga tcctgaaccg ccccaagcgc tacaacagcg gcaagctgga     2040

ggagttcgtg cagggcaacc tggagcgcga gtgcatggag gagaagtgca gcttcgagga     2100

ggcccgcgag gtgttcgaga acaccgagcg caccaccgag ttctggaagc agtacgtgga     2160

cggcgaccag tgcgagagca acccctgcct gaacggcggc agctgcaagg acgacatcaa     2220

cagctacgag tgctggtgcc ccttcggctt cgagggcaag aactgcgagc tggacgtgac     2280

ctgcaacatc aagaacggcc gctgcgagca gttctgcaag aacagcgccg acaacaaggt     2340

ggtgtgcagc tgcaccgagg gctaccgcct ggccgagaac cagaagagct gcgagcccgc     2400

cgtgcccttc ccctgcggcc gcgtgagcgt gagccagacc agcaagctga cccgcgccga     2460

ggccgtgttc cccgacgtgg actacgtgaa cagcaccgag gccgagacca tcctggacaa     2520

catcacccag agcacccaga gcttcaacga cttcacccgc gtggtgggcg gcgaggacgc     2580

caagcccggc cagttcccct ggcaggtggt gctgaacggc aaggtggacg ccttctgcgg     2640

cggcagcatc gtgaacgaga agtggatcgt gaccgccgcc cactgcgtgg agaccggcgt     2700

gaagatcacc gtggtggccg gcgagcacaa catcgaggag accgagcaca ccgagcagaa     2760

gcgcaacgtg atccgcatca tcccccacca caactacaac gccgccatca acaagtacaa     2820

ccacgacatc gccctgctgg agctggacga gcccctggtg ctgaacagct acgtgacccc     2880

catctgcatc gccgacaagg agtacaccaa catcttcctg aagttcggca gcggctacgt     2940

gagcggctgg ggccgcgtgt tccacaaggg ccgcagcgcc ctggtgctgc agtacctgcg     3000

cgtgcccctg gtggaccgcg ccacctgcct gctgagcacc aagttcacca tctacaacaa     3060

catgttctgc gccggcttcc acgagggcgg ccgcgacagc tgccagggcg acagcggcgg     3120

cccccacgtg accgaggtgg agggcaccag cttcctgacc ggcatcatca gctggggcga     3180

ggagtgcgcc atgaagggca agtacggcat ctacaccaag gtgagccgct acgtgaactg     3240

gatcaaggag aagaccaagc tgacctaatg aaagatggat ttccaaggtt aattcattgg     3300

aattgaaaat taacagcccc cccccccccc cccctgcaga tctgagccga attcctgcag     3360

cccgggggat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc     3420

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     3480

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag     3540

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct     3600

atggcttctg aggcggaaag aaccagctgg ggaccggtgg atctcgatag caggcatgct     3660

ggggagagat cgatctgagg aacccctagt gatggagttg gccactccct ctctgcgcgc     3720

tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt cgggcgacct ttggtcgccc     3780

ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc aacccccccc cccccccccc     3840

ccggcgattc tcttgtttgc tccagactct caggcaatga cctgatagcc tttgtagaga     3900

cctctcaaaa atagctaccc tctccggcat gaatttatca gctagaacgg ttgaatatca     3960

tattgatggt gatttgactg tctccggcct ttctcacccg tttgaatctt tacctacaca     4020

ttactcaggc attgcattta aaatatatga gggttctaaa aatttttatc cttgcgttga     4080

aataaaggct tctcccgcaa aagtattaca gggtcataat gtttttggta caaccgattt     4140

agctttatgc tctgaggctt tattgcttaa ttttgctaat tctttgcctt gcctgtatga     4200

tttattggat gttggaatcg cctgatgcgg tattttctcc ttacgcatct gtgcggtatt     4260

tcacaccgca tatggtgcac tctcagtaca atctgctctg atgccgcata gttatatggt     4320

gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa     4380

cacagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc     4440

ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt     4500

tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag     4560

gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg     4620

cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga     4680

caataaccct gataaatgct caataatatt gaaaaaggaa gagtatgagt attcaacatt     4740

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4800

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4860

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4920

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     4980

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5040

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5100

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5160

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5220

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5280

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5340

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5400

gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag     5460

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5520

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5580

ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt     5640

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac     5700

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag     5760

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg     5820

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca     5880

gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga     5940

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca     6000

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc     6060

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca     6120

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa     6180

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc     6240

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc     6300

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg     6360

cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat     6420

cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca     6480

gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca     6540

aaccgcctct ccccgcgcgt tggccgattc attaatg                              6577


<210>  35
<211>  6616
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE3-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  35
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

gggggacact gaagccaaat gggcttcagc tcctccccag ggatctccct acctgctgcc     1140

cattccaacc tggctctctc cctctccaca actgaagccc aggcctcttt ggatgctgct     1200

cacacatctt gcctccttat cttacctagc cagcgtctct gtccttggtg tctgtgcctg     1260

ccctggctgg agaggaaggg gctatatacc tgtctgttta cccaccccct gtcaggtgac     1320

agggactatg gatgggccca gtggggcagg gattatgtga ggataaacaa gttggagaaa     1380

tgggggagga gaggacaagc acatggaaga ctcatggtga tggggtgaga ggcagggggt     1440

acagctctta gtggaggcta agggggtagg tacccactgg gaggatgttg agtaagatgg     1500

aaaactactg atgacccttg cagagacaga gtattaggac atgtttgaac aggggccggg     1560

cgatcagcag gtagctctag aggatccccg tctgtctgca catttcgtag agcgagtgtt     1620

ccgatactct aatctcccta ggcaaggttc atatttgtgt aggttactta ttctcctttt     1680

gttgactaag tcaataatca gaatcagcag gtttggagtc agcttggcag ggatcagcag     1740

cctgggttgg aaggaggggg tataaaagcc ccttcaccag gagaagccgt cacacagatc     1800

cacaagctcc tggctagaaa gaggtaaggg tttaagggat ggttggttgg tggggtatta     1860

atgtttaatt acctggagca cctgcctgaa atcacttttt ttcaggttgg gctagcccac     1920

catgcagcgc gtgaacatga tcatggccga gagccccggc ctgatcacca tctgcctgct     1980

gggctacctg ctgagcgccg agtgcaccgt gttcctggac cacgagaacg ccaacaagat     2040

cctgaaccgc cccaagcgct acaacagcgg caagctggag gagttcgtgc agggcaacct     2100

ggagcgcgag tgcatggagg agaagtgcag cttcgaggag gcccgcgagg tgttcgagaa     2160

caccgagcgc accaccgagt tctggaagca gtacgtggac ggcgaccagt gcgagagcaa     2220

cccctgcctg aacggcggca gctgcaagga cgacatcaac agctacgagt gctggtgccc     2280

cttcggcttc gagggcaaga actgcgagct ggacgtgacc tgcaacatca agaacggccg     2340

ctgcgagcag ttctgcaaga acagcgccga caacaaggtg gtgtgcagct gcaccgaggg     2400

ctaccgcctg gccgagaacc agaagagctg cgagcccgcc gtgcccttcc cctgcggccg     2460

cgtgagcgtg agccagacca gcaagctgac ccgcgccgag gccgtgttcc ccgacgtgga     2520

ctacgtgaac agcaccgagg ccgagaccat cctggacaac atcacccaga gcacccagag     2580

cttcaacgac ttcacccgcg tggtgggcgg cgaggacgcc aagcccggcc agttcccctg     2640

gcaggtggtg ctgaacggca aggtggacgc cttctgcggc ggcagcatcg tgaacgagaa     2700

gtggatcgtg accgccgccc actgcgtgga gaccggcgtg aagatcaccg tggtggccgg     2760

cgagcacaac atcgaggaga ccgagcacac cgagcagaag cgcaacgtga tccgcatcat     2820

cccccaccac aactacaacg ccgccatcaa caagtacaac cacgacatcg ccctgctgga     2880

gctggacgag cccctggtgc tgaacagcta cgtgaccccc atctgcatcg ccgacaagga     2940

gtacaccaac atcttcctga agttcggcag cggctacgtg agcggctggg gccgcgtgtt     3000

ccacaagggc cgcagcgccc tggtgctgca gtacctgcgc gtgcccctgg tggaccgcgc     3060

cacctgcctg ctgagcacca agttcaccat ctacaacaac atgttctgcg ccggcttcca     3120

cgagggcggc cgcgacagct gccagggcga cagcggcggc ccccacgtga ccgaggtgga     3180

gggcaccagc ttcctgaccg gcatcatcag ctggggcgag gagtgcgcca tgaagggcaa     3240

gtacggcatc tacaccaagg tgagccgcta cgtgaactgg atcaaggaga agaccaagct     3300

gacctaatga aagatggatt tccaaggtta attcattgga attgaaaatt aacagccccc     3360

cccccccccc ccctgcagat ctgagccgaa ttcctgcagc ccgggggatc agcctcgact     3420

gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg     3480

gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg     3540

agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg     3600

gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggcggaaaga     3660

accagctggg gaccggtgga tctcgatagc aggcatgctg gggagagatc gatctgagga     3720

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgc     3780

ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc     3840

gcgcagagag ggagtggcca accccccccc cccccccccc cggcgattct cttgtttgct     3900

ccagactctc aggcaatgac ctgatagcct ttgtagagac ctctcaaaaa tagctaccct     3960

ctccggcatg aatttatcag ctagaacggt tgaatatcat attgatggtg atttgactgt     4020

ctccggcctt tctcacccgt ttgaatcttt acctacacat tactcaggca ttgcatttaa     4080

aatatatgag ggttctaaaa atttttatcc ttgcgttgaa ataaaggctt ctcccgcaaa     4140

agtattacag ggtcataatg tttttggtac aaccgattta gctttatgct ctgaggcttt     4200

attgcttaat tttgctaatt ctttgccttg cctgtatgat ttattggatg ttggaatcgc     4260

ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat atggtgcact     4320

ctcagtacaa tctgctctga tgccgcatag ttatatggtg cactctcagt acaatctgct     4380

ctgatgccgc atagttaagc cagccccgac acccgccaac acagccagcc ccgacacccg     4440

ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa     4500

gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc     4560

gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg     4620

gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta     4680

tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctc     4740

aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct     4800

tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag     4860

atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta     4920

agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc     4980

tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca     5040

tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg     5100

atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg     5160

ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca     5220

tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa     5280

acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa     5340

ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg gaggcggata     5400

aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat     5460

ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc     5520

cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata     5580

gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt     5640

actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga     5700

agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag     5760

cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa     5820

tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag     5880

agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg     5940

tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat     6000

acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta     6060

ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg     6120

gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc     6180

gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa     6240

gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc     6300

tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt     6360

caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct     6420

tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc     6480

gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg     6540

agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt     6600

ggccgattca ttaatg                                                     6616


<210>  36
<211>  6656
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE4-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  36
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

gggagttaat gtgtaatgag acggggagaa aacaggagag cccagaatga cctggatgct     1140

gatcactgaa cataccctac ccccagtaaa acaaattcag aaaacagctt ccgcccgtcc     1200

cctcccaatg gagggctctg gcaggaaaag aggtgaataa gaggcttcta ccagggtaaa     1260

ggttgaaggc acctggtcat ttgatcacct tatcagttct aggcagtgat tagccaatat     1320

tgagtcagca ggggcaatag ccctggccct tgtctcactc ctgttggggg tgggggaggg     1380

ggagaggtac attcccaggt tcaaagcatt tgggtgaaat cagttaaata gatatcagaa     1440

gcttttgtat ctttcaccct tttgcccccc aagcatactc gctgagtatg tggaacattc     1500

ctgagggtgg tacccactgg gaggatgttg agtaagatgg aaaactactg atgacccttg     1560

cagagacaga gtattaggac atgtttgaac aggggccggg cgatcagcag gtagctctag     1620

aggatccccg tctgtctgca catttcgtag agcgagtgtt ccgatactct aatctcccta     1680

ggcaaggttc atatttgtgt aggttactta ttctcctttt gttgactaag tcaataatca     1740

gaatcagcag gtttggagtc agcttggcag ggatcagcag cctgggttgg aaggaggggg     1800

tataaaagcc ccttcaccag gagaagccgt cacacagatc cacaagctcc tggctagaaa     1860

gaggtaaggg tttaagggat ggttggttgg tggggtatta atgtttaatt acctggagca     1920

cctgcctgaa atcacttttt ttcaggttgg gctagcccac catgcagcgc gtgaacatga     1980

tcatggccga gagccccggc ctgatcacca tctgcctgct gggctacctg ctgagcgccg     2040

agtgcaccgt gttcctggac cacgagaacg ccaacaagat cctgaaccgc cccaagcgct     2100

acaacagcgg caagctggag gagttcgtgc agggcaacct ggagcgcgag tgcatggagg     2160

agaagtgcag cttcgaggag gcccgcgagg tgttcgagaa caccgagcgc accaccgagt     2220

tctggaagca gtacgtggac ggcgaccagt gcgagagcaa cccctgcctg aacggcggca     2280

gctgcaagga cgacatcaac agctacgagt gctggtgccc cttcggcttc gagggcaaga     2340

actgcgagct ggacgtgacc tgcaacatca agaacggccg ctgcgagcag ttctgcaaga     2400

acagcgccga caacaaggtg gtgtgcagct gcaccgaggg ctaccgcctg gccgagaacc     2460

agaagagctg cgagcccgcc gtgcccttcc cctgcggccg cgtgagcgtg agccagacca     2520

gcaagctgac ccgcgccgag gccgtgttcc ccgacgtgga ctacgtgaac agcaccgagg     2580

ccgagaccat cctggacaac atcacccaga gcacccagag cttcaacgac ttcacccgcg     2640

tggtgggcgg cgaggacgcc aagcccggcc agttcccctg gcaggtggtg ctgaacggca     2700

aggtggacgc cttctgcggc ggcagcatcg tgaacgagaa gtggatcgtg accgccgccc     2760

actgcgtgga gaccggcgtg aagatcaccg tggtggccgg cgagcacaac atcgaggaga     2820

ccgagcacac cgagcagaag cgcaacgtga tccgcatcat cccccaccac aactacaacg     2880

ccgccatcaa caagtacaac cacgacatcg ccctgctgga gctggacgag cccctggtgc     2940

tgaacagcta cgtgaccccc atctgcatcg ccgacaagga gtacaccaac atcttcctga     3000

agttcggcag cggctacgtg agcggctggg gccgcgtgtt ccacaagggc cgcagcgccc     3060

tggtgctgca gtacctgcgc gtgcccctgg tggaccgcgc cacctgcctg ctgagcacca     3120

agttcaccat ctacaacaac atgttctgcg ccggcttcca cgagggcggc cgcgacagct     3180

gccagggcga cagcggcggc ccccacgtga ccgaggtgga gggcaccagc ttcctgaccg     3240

gcatcatcag ctggggcgag gagtgcgcca tgaagggcaa gtacggcatc tacaccaagg     3300

tgagccgcta cgtgaactgg atcaaggaga agaccaagct gacctaatga aagatggatt     3360

tccaaggtta attcattgga attgaaaatt aacagccccc cccccccccc ccctgcagat     3420

ctgagccgaa ttcctgcagc ccgggggatc agcctcgact gtgccttcta gttgccagcc     3480

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     3540

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     3600

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     3660

tggggatgcg gtgggctcta tggcttctga ggcggaaaga accagctggg gaccggtgga     3720

tctcgatagc aggcatgctg gggagagatc gatctgagga acccctagtg atggagttgg     3780

ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc     3840

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     3900

accccccccc cccccccccc cggcgattct cttgtttgct ccagactctc aggcaatgac     3960

ctgatagcct ttgtagagac ctctcaaaaa tagctaccct ctccggcatg aatttatcag     4020

ctagaacggt tgaatatcat attgatggtg atttgactgt ctccggcctt tctcacccgt     4080

ttgaatcttt acctacacat tactcaggca ttgcatttaa aatatatgag ggttctaaaa     4140

atttttatcc ttgcgttgaa ataaaggctt ctcccgcaaa agtattacag ggtcataatg     4200

tttttggtac aaccgattta gctttatgct ctgaggcttt attgcttaat tttgctaatt     4260

ctttgccttg cctgtatgat ttattggatg ttggaatcgc ctgatgcggt attttctcct     4320

tacgcatctg tgcggtattt cacaccgcat atggtgcact ctcagtacaa tctgctctga     4380

tgccgcatag ttatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc     4440

cagccccgac acccgccaac acagccagcc ccgacacccg ccaacacccg ctgacgcgcc     4500

ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag     4560

ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt     4620

gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg     4680

cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa     4740

tatgtatccg ctcatgagac aataaccctg ataaatgctc aataatattg aaaaaggaag     4800

agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt     4860

cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt     4920

gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc     4980

cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta     5040

tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac     5100

ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa     5160

ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg     5220

atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc     5280

cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg     5340

atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta     5400

gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg     5460

cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg     5520

tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc     5580

tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt     5640

gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt     5700

gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc     5760

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     5820

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     5880

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     5940

aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag     6000

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     6060

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     6120

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     6180

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc     6240

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     6300

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     6360

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     6420

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     6480

atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga     6540

gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg     6600

gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatg         6656


<210>  37
<211>  6490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE5-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  37
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggtgttttgt tttggtgacc taactggtca aatgacctat taagaatatt tcatagaacg     1140

aatgttccga tgctctaatc tctctagaca aggttcatat ttgtatgggt tacttattct     1200

ctctttgttg actaagtcaa taatcagaat cagcaggttt gcagtcagat tggcagggat     1260

aagcagccta gctcaggaga agtgagtata aaagccccag gctgggagca gccatcacag     1320

aagtccactc attcttggca ggggtaccca ctgggaggat gttgagtaag atggaaaact     1380

actgatgacc cttgcagaga cagagtatta ggacatgttt gaacaggggc cgggcgatca     1440

gcaggtagct ctagaggatc cccgtctgtc tgcacatttc gtagagcgag tgttccgata     1500

ctctaatctc cctaggcaag gttcatattt gtgtaggtta cttattctcc ttttgttgac     1560

taagtcaata atcagaatca gcaggtttgg agtcagcttg gcagggatca gcagcctggg     1620

ttggaaggag ggggtataaa agccccttca ccaggagaag ccgtcacaca gatccacaag     1680

ctcctggcta gaaagaggta agggtttaag ggatggttgg ttggtggggt attaatgttt     1740

aattacctgg agcacctgcc tgaaatcact ttttttcagg ttgggctagc ccaccatgca     1800

gcgcgtgaac atgatcatgg ccgagagccc cggcctgatc accatctgcc tgctgggcta     1860

cctgctgagc gccgagtgca ccgtgttcct ggaccacgag aacgccaaca agatcctgaa     1920

ccgccccaag cgctacaaca gcggcaagct ggaggagttc gtgcagggca acctggagcg     1980

cgagtgcatg gaggagaagt gcagcttcga ggaggcccgc gaggtgttcg agaacaccga     2040

gcgcaccacc gagttctgga agcagtacgt ggacggcgac cagtgcgaga gcaacccctg     2100

cctgaacggc ggcagctgca aggacgacat caacagctac gagtgctggt gccccttcgg     2160

cttcgagggc aagaactgcg agctggacgt gacctgcaac atcaagaacg gccgctgcga     2220

gcagttctgc aagaacagcg ccgacaacaa ggtggtgtgc agctgcaccg agggctaccg     2280

cctggccgag aaccagaaga gctgcgagcc cgccgtgccc ttcccctgcg gccgcgtgag     2340

cgtgagccag accagcaagc tgacccgcgc cgaggccgtg ttccccgacg tggactacgt     2400

gaacagcacc gaggccgaga ccatcctgga caacatcacc cagagcaccc agagcttcaa     2460

cgacttcacc cgcgtggtgg gcggcgagga cgccaagccc ggccagttcc cctggcaggt     2520

ggtgctgaac ggcaaggtgg acgccttctg cggcggcagc atcgtgaacg agaagtggat     2580

cgtgaccgcc gcccactgcg tggagaccgg cgtgaagatc accgtggtgg ccggcgagca     2640

caacatcgag gagaccgagc acaccgagca gaagcgcaac gtgatccgca tcatccccca     2700

ccacaactac aacgccgcca tcaacaagta caaccacgac atcgccctgc tggagctgga     2760

cgagcccctg gtgctgaaca gctacgtgac ccccatctgc atcgccgaca aggagtacac     2820

caacatcttc ctgaagttcg gcagcggcta cgtgagcggc tggggccgcg tgttccacaa     2880

gggccgcagc gccctggtgc tgcagtacct gcgcgtgccc ctggtggacc gcgccacctg     2940

cctgctgagc accaagttca ccatctacaa caacatgttc tgcgccggct tccacgaggg     3000

cggccgcgac agctgccagg gcgacagcgg cggcccccac gtgaccgagg tggagggcac     3060

cagcttcctg accggcatca tcagctgggg cgaggagtgc gccatgaagg gcaagtacgg     3120

catctacacc aaggtgagcc gctacgtgaa ctggatcaag gagaagacca agctgaccta     3180

atgaaagatg gatttccaag gttaattcat tggaattgaa aattaacagc cccccccccc     3240

ccccccctgc agatctgagc cgaattcctg cagcccgggg gatcagcctc gactgtgcct     3300

tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     3360

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     3420

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     3480

aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc     3540

tggggaccgg tggatctcga tagcaggcat gctggggaga gatcgatctg aggaacccct     3600

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc     3660

aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag     3720

agagggagtg gccaaccccc cccccccccc cccccggcga ttctcttgtt tgctccagac     3780

tctcaggcaa tgacctgata gcctttgtag agacctctca aaaatagcta ccctctccgg     3840

catgaattta tcagctagaa cggttgaata tcatattgat ggtgatttga ctgtctccgg     3900

cctttctcac ccgtttgaat ctttacctac acattactca ggcattgcat ttaaaatata     3960

tgagggttct aaaaattttt atccttgcgt tgaaataaag gcttctcccg caaaagtatt     4020

acagggtcat aatgtttttg gtacaaccga tttagcttta tgctctgagg ctttattgct     4080

taattttgct aattctttgc cttgcctgta tgatttattg gatgttggaa tcgcctgatg     4140

cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatggtg cactctcagt     4200

acaatctgct ctgatgccgc atagttatat ggtgcactct cagtacaatc tgctctgatg     4260

ccgcatagtt aagccagccc cgacacccgc caacacagcc agccccgaca cccgccaaca     4320

cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg     4380

accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga     4440

cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct     4500

tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc     4560

taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gctcaataat     4620

attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg     4680

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg     4740

aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc     4800

ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat     4860

gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact     4920

attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca     4980

tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact     5040

tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg     5100

atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg     5160

agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg     5220

aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg     5280

caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag     5340

ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc     5400

gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga     5460

tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat     5520

atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc     5580

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag     5640

accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct     5700

gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac     5760

caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc     5820

tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg     5880

ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt     5940

tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt     6000

gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc     6060

tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca     6120

gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata     6180

gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg     6240

ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct     6300

ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta     6360

ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag     6420

tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga     6480

ttcattaatg                                                            6490


<210>  38
<211>  6497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE6-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  38
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggaggggggc ccctggggct gacagggact ggaagctctg agctggccag agggatgttg     1140

caatcctgcc agggtcttgt ctatgctgtc cttttcacaa ccatccccct actgccaggc     1200

tgacacgtgg ttgcgggggc acaaggccag ccaacctaga gtctgaggct aggcggagga     1260

caccctcccc accagctgcc agggtcactg gcggtcaaag gcagctggtg gggaaggcat     1320

tggactccag ccttggggga cggatgtagg gtacccactg ggaggatgtt gagtaagatg     1380

gaaaactact gatgaccctt gcagagacag agtattagga catgtttgaa caggggccgg     1440

gcgatcagca ggtagctcta gaggatcccc gtctgtctgc acatttcgta gagcgagtgt     1500

tccgatactc taatctccct aggcaaggtt catatttgtg taggttactt attctccttt     1560

tgttgactaa gtcaataatc agaatcagca ggtttggagt cagcttggca gggatcagca     1620

gcctgggttg gaaggagggg gtataaaagc cccttcacca ggagaagccg tcacacagat     1680

ccacaagctc ctggctagaa agaggtaagg gtttaaggga tggttggttg gtggggtatt     1740

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg ggctagccca     1800

ccatgcagcg cgtgaacatg atcatggccg agagccccgg cctgatcacc atctgcctgc     1860

tgggctacct gctgagcgcc gagtgcaccg tgttcctgga ccacgagaac gccaacaaga     1920

tcctgaaccg ccccaagcgc tacaacagcg gcaagctgga ggagttcgtg cagggcaacc     1980

tggagcgcga gtgcatggag gagaagtgca gcttcgagga ggcccgcgag gtgttcgaga     2040

acaccgagcg caccaccgag ttctggaagc agtacgtgga cggcgaccag tgcgagagca     2100

acccctgcct gaacggcggc agctgcaagg acgacatcaa cagctacgag tgctggtgcc     2160

ccttcggctt cgagggcaag aactgcgagc tggacgtgac ctgcaacatc aagaacggcc     2220

gctgcgagca gttctgcaag aacagcgccg acaacaaggt ggtgtgcagc tgcaccgagg     2280

gctaccgcct ggccgagaac cagaagagct gcgagcccgc cgtgcccttc ccctgcggcc     2340

gcgtgagcgt gagccagacc agcaagctga cccgcgccga ggccgtgttc cccgacgtgg     2400

actacgtgaa cagcaccgag gccgagacca tcctggacaa catcacccag agcacccaga     2460

gcttcaacga cttcacccgc gtggtgggcg gcgaggacgc caagcccggc cagttcccct     2520

ggcaggtggt gctgaacggc aaggtggacg ccttctgcgg cggcagcatc gtgaacgaga     2580

agtggatcgt gaccgccgcc cactgcgtgg agaccggcgt gaagatcacc gtggtggccg     2640

gcgagcacaa catcgaggag accgagcaca ccgagcagaa gcgcaacgtg atccgcatca     2700

tcccccacca caactacaac gccgccatca acaagtacaa ccacgacatc gccctgctgg     2760

agctggacga gcccctggtg ctgaacagct acgtgacccc catctgcatc gccgacaagg     2820

agtacaccaa catcttcctg aagttcggca gcggctacgt gagcggctgg ggccgcgtgt     2880

tccacaaggg ccgcagcgcc ctggtgctgc agtacctgcg cgtgcccctg gtggaccgcg     2940

ccacctgcct gctgagcacc aagttcacca tctacaacaa catgttctgc gccggcttcc     3000

acgagggcgg ccgcgacagc tgccagggcg acagcggcgg cccccacgtg accgaggtgg     3060

agggcaccag cttcctgacc ggcatcatca gctggggcga ggagtgcgcc atgaagggca     3120

agtacggcat ctacaccaag gtgagccgct acgtgaactg gatcaaggag aagaccaagc     3180

tgacctaatg aaagatggat ttccaaggtt aattcattgg aattgaaaat taacagcccc     3240

cccccccccc cccctgcaga tctgagccga attcctgcag cccgggggat cagcctcgac     3300

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     3360

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     3420

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     3480

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag     3540

aaccagctgg ggaccggtgg atctcgatag caggcatgct ggggagagat cgatctgagg     3600

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     3660

cccgggcaaa gcccgggcgt cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag     3720

cgcgcagaga gggagtggcc aacccccccc cccccccccc ccggcgattc tcttgtttgc     3780

tccagactct caggcaatga cctgatagcc tttgtagaga cctctcaaaa atagctaccc     3840

tctccggcat gaatttatca gctagaacgg ttgaatatca tattgatggt gatttgactg     3900

tctccggcct ttctcacccg tttgaatctt tacctacaca ttactcaggc attgcattta     3960

aaatatatga gggttctaaa aatttttatc cttgcgttga aataaaggct tctcccgcaa     4020

aagtattaca gggtcataat gtttttggta caaccgattt agctttatgc tctgaggctt     4080

tattgcttaa ttttgctaat tctttgcctt gcctgtatga tttattggat gttggaatcg     4140

cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatggtgcac     4200

tctcagtaca atctgctctg atgccgcata gttatatggt gcactctcag tacaatctgc     4260

tctgatgccg catagttaag ccagccccga cacccgccaa cacagccagc cccgacaccc     4320

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca     4380

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg     4440

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat     4500

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt     4560

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct     4620

caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc     4680

ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa     4740

gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt     4800

aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt     4860

ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc     4920

atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg     4980

gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg     5040

gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac     5100

atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca     5160

aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta     5220

actggcgaac tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat     5280

aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa     5340

tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag     5400

ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat     5460

agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt     5520

tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg     5580

aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga     5640

gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta     5700

atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa     5760

gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact     5820

gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca     5880

tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt     5940

accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg     6000

ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag     6060

cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta     6120

agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat     6180

ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg     6240

tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc     6300

ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac     6360

cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc     6420

gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt     6480

tggccgattc attaatg                                                    6497


<210>  39
<211>  6543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE7-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  39
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggtacaggcc tggggtcccg gcttagagga cctctgagag ctccggggcc ccttctgggt     1140

cgtggttgcc tcatcgtggt cgggtgggtc tccaggttct cccaggctca gtcccgcagg     1200

cgccaaatct gcgcaggaga gcactagcaa ccgatgacgt attgaggccc acacctctgg     1260

gattggctgt cctgcttcga cagccttgaa agtgggtaag ctgggtgggg ggctctggga     1320

gaggtcagtg ctgagtaagg caattcccag cagcttgagc cccaccaggt cactccagta     1380

ttcctcccca ttcttggtac ccactgggag gatgttgagt aagatggaaa actactgatg     1440

acccttgcag agacagagta ttaggacatg tttgaacagg ggccgggcga tcagcaggta     1500

gctctagagg atccccgtct gtctgcacat ttcgtagagc gagtgttccg atactctaat     1560

ctccctaggc aaggttcata tttgtgtagg ttacttattc tccttttgtt gactaagtca     1620

ataatcagaa tcagcaggtt tggagtcagc ttggcaggga tcagcagcct gggttggaag     1680

gagggggtat aaaagcccct tcaccaggag aagccgtcac acagatccac aagctcctgg     1740

ctagaaagag gtaagggttt aagggatggt tggttggtgg ggtattaatg tttaattacc     1800

tggagcacct gcctgaaatc actttttttc aggttgggct agcccaccat gcagcgcgtg     1860

aacatgatca tggccgagag ccccggcctg atcaccatct gcctgctggg ctacctgctg     1920

agcgccgagt gcaccgtgtt cctggaccac gagaacgcca acaagatcct gaaccgcccc     1980

aagcgctaca acagcggcaa gctggaggag ttcgtgcagg gcaacctgga gcgcgagtgc     2040

atggaggaga agtgcagctt cgaggaggcc cgcgaggtgt tcgagaacac cgagcgcacc     2100

accgagttct ggaagcagta cgtggacggc gaccagtgcg agagcaaccc ctgcctgaac     2160

ggcggcagct gcaaggacga catcaacagc tacgagtgct ggtgcccctt cggcttcgag     2220

ggcaagaact gcgagctgga cgtgacctgc aacatcaaga acggccgctg cgagcagttc     2280

tgcaagaaca gcgccgacaa caaggtggtg tgcagctgca ccgagggcta ccgcctggcc     2340

gagaaccaga agagctgcga gcccgccgtg cccttcccct gcggccgcgt gagcgtgagc     2400

cagaccagca agctgacccg cgccgaggcc gtgttccccg acgtggacta cgtgaacagc     2460

accgaggccg agaccatcct ggacaacatc acccagagca cccagagctt caacgacttc     2520

acccgcgtgg tgggcggcga ggacgccaag cccggccagt tcccctggca ggtggtgctg     2580

aacggcaagg tggacgcctt ctgcggcggc agcatcgtga acgagaagtg gatcgtgacc     2640

gccgcccact gcgtggagac cggcgtgaag atcaccgtgg tggccggcga gcacaacatc     2700

gaggagaccg agcacaccga gcagaagcgc aacgtgatcc gcatcatccc ccaccacaac     2760

tacaacgccg ccatcaacaa gtacaaccac gacatcgccc tgctggagct ggacgagccc     2820

ctggtgctga acagctacgt gacccccatc tgcatcgccg acaaggagta caccaacatc     2880

ttcctgaagt tcggcagcgg ctacgtgagc ggctggggcc gcgtgttcca caagggccgc     2940

agcgccctgg tgctgcagta cctgcgcgtg cccctggtgg accgcgccac ctgcctgctg     3000

agcaccaagt tcaccatcta caacaacatg ttctgcgccg gcttccacga gggcggccgc     3060

gacagctgcc agggcgacag cggcggcccc cacgtgaccg aggtggaggg caccagcttc     3120

ctgaccggca tcatcagctg gggcgaggag tgcgccatga agggcaagta cggcatctac     3180

accaaggtga gccgctacgt gaactggatc aaggagaaga ccaagctgac ctaatgaaag     3240

atggatttcc aaggttaatt cattggaatt gaaaattaac agcccccccc cccccccccc     3300

tgcagatctg agccgaattc ctgcagcccg ggggatcagc ctcgactgtg ccttctagtt     3360

gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc     3420

ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt     3480

ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca     3540

ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc agctggggac     3600

cggtggatct cgatagcagg catgctgggg agagatcgat ctgaggaacc cctagtgatg     3660

gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc     3720

gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga     3780

gtggccaacc cccccccccc ccccccccgg cgattctctt gtttgctcca gactctcagg     3840

caatgacctg atagcctttg tagagacctc tcaaaaatag ctaccctctc cggcatgaat     3900

ttatcagcta gaacggttga atatcatatt gatggtgatt tgactgtctc cggcctttct     3960

cacccgtttg aatctttacc tacacattac tcaggcattg catttaaaat atatgagggt     4020

tctaaaaatt tttatccttg cgttgaaata aaggcttctc ccgcaaaagt attacagggt     4080

cataatgttt ttggtacaac cgatttagct ttatgctctg aggctttatt gcttaatttt     4140

gctaattctt tgccttgcct gtatgattta ttggatgttg gaatcgcctg atgcggtatt     4200

ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct     4260

gctctgatgc cgcatagtta tatggtgcac tctcagtaca atctgctctg atgccgcata     4320

gttaagccag ccccgacacc cgccaacaca gccagccccg acacccgcca acacccgctg     4380

acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct     4440

ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg     4500

gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt     4560

caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac     4620

attcaaatat gtatccgctc atgagacaat aaccctgata aatgctcaat aatattgaaa     4680

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt     4740

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca     4800

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag     4860

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc     4920

ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca     4980

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt     5040

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct     5100

gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt     5160

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga     5220

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact     5280

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc     5340

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga     5400

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt     5460

agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga     5520

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact     5580

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga     5640

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt     5700

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca     5760

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct     5820

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta     5880

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct     5940

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc     6000

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca     6060

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga     6120

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg     6180

aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt     6240

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag     6300

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt     6360

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt     6420

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga     6480

ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta     6540

atg                                                                   6543


<210>  40
<211>  6743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE8-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  40
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggcccgaacg aataaacccc ttccttaact cagcgtctga ggaattttgt ctgcggctcc     1140

tcctgctaca ttctgagtgg ggaaagggac taaggtggtc tgaggacccc acagagtcag     1200

gaagattgag aggtgagagt gctgaacggg gaggggcttt ggggctaagg gaagtgcccg     1260

ggaccccacc tgaccccaac gctcacggga caggggcaga ggagaaaaac gtgggtggac     1320

agagggaggc aggcggtcag gggaaggctc aggaggaggg agatcaacat caacctgccc     1380

cgccccctcc ccagcctgat aaaggtcctg cgggcaggac aggacctccc aaccaagccc     1440

tccagcaagg attcaggttg gtgctgagtg cctgggaggg acacccgcct acactctgca     1500

agaaactcaa aaagggagat gaggggatcg tgggagggag gtagggaggg aggagggtgc     1560

cactgatccc ctgaacccct gcctctgcct ccagaggtac ccactgggag gatgttgagt     1620

aagatggaaa actactgatg acccttgcag agacagagta ttaggacatg tttgaacagg     1680

ggccgggcga tcagcaggta gctctagagg atccccgtct gtctgcacat ttcgtagagc     1740

gagtgttccg atactctaat ctccctaggc aaggttcata tttgtgtagg ttacttattc     1800

tccttttgtt gactaagtca ataatcagaa tcagcaggtt tggagtcagc ttggcaggga     1860

tcagcagcct gggttggaag gagggggtat aaaagcccct tcaccaggag aagccgtcac     1920

acagatccac aagctcctgg ctagaaagag gtaagggttt aagggatggt tggttggtgg     1980

ggtattaatg tttaattacc tggagcacct gcctgaaatc actttttttc aggttgggct     2040

agcccaccat gcagcgcgtg aacatgatca tggccgagag ccccggcctg atcaccatct     2100

gcctgctggg ctacctgctg agcgccgagt gcaccgtgtt cctggaccac gagaacgcca     2160

acaagatcct gaaccgcccc aagcgctaca acagcggcaa gctggaggag ttcgtgcagg     2220

gcaacctgga gcgcgagtgc atggaggaga agtgcagctt cgaggaggcc cgcgaggtgt     2280

tcgagaacac cgagcgcacc accgagttct ggaagcagta cgtggacggc gaccagtgcg     2340

agagcaaccc ctgcctgaac ggcggcagct gcaaggacga catcaacagc tacgagtgct     2400

ggtgcccctt cggcttcgag ggcaagaact gcgagctgga cgtgacctgc aacatcaaga     2460

acggccgctg cgagcagttc tgcaagaaca gcgccgacaa caaggtggtg tgcagctgca     2520

ccgagggcta ccgcctggcc gagaaccaga agagctgcga gcccgccgtg cccttcccct     2580

gcggccgcgt gagcgtgagc cagaccagca agctgacccg cgccgaggcc gtgttccccg     2640

acgtggacta cgtgaacagc accgaggccg agaccatcct ggacaacatc acccagagca     2700

cccagagctt caacgacttc acccgcgtgg tgggcggcga ggacgccaag cccggccagt     2760

tcccctggca ggtggtgctg aacggcaagg tggacgcctt ctgcggcggc agcatcgtga     2820

acgagaagtg gatcgtgacc gccgcccact gcgtggagac cggcgtgaag atcaccgtgg     2880

tggccggcga gcacaacatc gaggagaccg agcacaccga gcagaagcgc aacgtgatcc     2940

gcatcatccc ccaccacaac tacaacgccg ccatcaacaa gtacaaccac gacatcgccc     3000

tgctggagct ggacgagccc ctggtgctga acagctacgt gacccccatc tgcatcgccg     3060

acaaggagta caccaacatc ttcctgaagt tcggcagcgg ctacgtgagc ggctggggcc     3120

gcgtgttcca caagggccgc agcgccctgg tgctgcagta cctgcgcgtg cccctggtgg     3180

accgcgccac ctgcctgctg agcaccaagt tcaccatcta caacaacatg ttctgcgccg     3240

gcttccacga gggcggccgc gacagctgcc agggcgacag cggcggcccc cacgtgaccg     3300

aggtggaggg caccagcttc ctgaccggca tcatcagctg gggcgaggag tgcgccatga     3360

agggcaagta cggcatctac accaaggtga gccgctacgt gaactggatc aaggagaaga     3420

ccaagctgac ctaatgaaag atggatttcc aaggttaatt cattggaatt gaaaattaac     3480

agcccccccc cccccccccc tgcagatctg agccgaattc ctgcagcccg ggggatcagc     3540

ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt     3600

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca     3660

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     3720

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc     3780

ggaaagaacc agctggggac cggtggatct cgatagcagg catgctgggg agagatcgat     3840

ctgaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     3900

aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg     3960

agcgagcgcg cagagaggga gtggccaacc cccccccccc ccccccccgg cgattctctt     4020

gtttgctcca gactctcagg caatgacctg atagcctttg tagagacctc tcaaaaatag     4080

ctaccctctc cggcatgaat ttatcagcta gaacggttga atatcatatt gatggtgatt     4140

tgactgtctc cggcctttct cacccgtttg aatctttacc tacacattac tcaggcattg     4200

catttaaaat atatgagggt tctaaaaatt tttatccttg cgttgaaata aaggcttctc     4260

ccgcaaaagt attacagggt cataatgttt ttggtacaac cgatttagct ttatgctctg     4320

aggctttatt gcttaatttt gctaattctt tgccttgcct gtatgattta ttggatgttg     4380

gaatcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg     4440

gtgcactctc agtacaatct gctctgatgc cgcatagtta tatggtgcac tctcagtaca     4500

atctgctctg atgccgcata gttaagccag ccccgacacc cgccaacaca gccagccccg     4560

acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta     4620

cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc     4680

gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     4740

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     4800

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     4860

aatgctcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt     4920

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa     4980

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac     5040

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt     5100

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt     5160

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat     5220

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac     5280

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg     5340

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc     5400

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa     5460

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag     5520

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct     5580

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat     5640

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa     5700

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     5760

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     5820

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     5880

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     5940

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     6000

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     6060

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     6120

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     6180

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     6240

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     6300

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     6360

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     6420

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     6480

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     6540

ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg     6600

gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag     6660

cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc     6720

gcgcgttggc cgattcatta atg                                             6743


<210>  41
<211>  6536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE9-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  41
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

gggatgagtg cagggaaccc cgaccccacc cgggagacct gcaagcctgc agacactccc     1140

ctcccgcccc cactgaaccc ttgacccctg ccctgcagcc cccgcagctt gctgtttgcc     1200

cactctattt gcccagcccc agggacagag ctgatccttg aactcttaag ttccacattg     1260

ccaggaccag tgagcagcaa cagggccggg gctgggctta tcagcctccc agcccagacc     1320

ctggctgcag acataaatag gccctgcaag agctggctgc ttagagactg cgagaaggag     1380

gtgcgtccgg tacccactgg gaggatgttg agtaagatgg aaaactactg atgacccttg     1440

cagagacaga gtattaggac atgtttgaac aggggccggg cgatcagcag gtagctctag     1500

aggatccccg tctgtctgca catttcgtag agcgagtgtt ccgatactct aatctcccta     1560

ggcaaggttc atatttgtgt aggttactta ttctcctttt gttgactaag tcaataatca     1620

gaatcagcag gtttggagtc agcttggcag ggatcagcag cctgggttgg aaggaggggg     1680

tataaaagcc ccttcaccag gagaagccgt cacacagatc cacaagctcc tggctagaaa     1740

gaggtaaggg tttaagggat ggttggttgg tggggtatta atgtttaatt acctggagca     1800

cctgcctgaa atcacttttt ttcaggttgg gctagcccac catgcagcgc gtgaacatga     1860

tcatggccga gagccccggc ctgatcacca tctgcctgct gggctacctg ctgagcgccg     1920

agtgcaccgt gttcctggac cacgagaacg ccaacaagat cctgaaccgc cccaagcgct     1980

acaacagcgg caagctggag gagttcgtgc agggcaacct ggagcgcgag tgcatggagg     2040

agaagtgcag cttcgaggag gcccgcgagg tgttcgagaa caccgagcgc accaccgagt     2100

tctggaagca gtacgtggac ggcgaccagt gcgagagcaa cccctgcctg aacggcggca     2160

gctgcaagga cgacatcaac agctacgagt gctggtgccc cttcggcttc gagggcaaga     2220

actgcgagct ggacgtgacc tgcaacatca agaacggccg ctgcgagcag ttctgcaaga     2280

acagcgccga caacaaggtg gtgtgcagct gcaccgaggg ctaccgcctg gccgagaacc     2340

agaagagctg cgagcccgcc gtgcccttcc cctgcggccg cgtgagcgtg agccagacca     2400

gcaagctgac ccgcgccgag gccgtgttcc ccgacgtgga ctacgtgaac agcaccgagg     2460

ccgagaccat cctggacaac atcacccaga gcacccagag cttcaacgac ttcacccgcg     2520

tggtgggcgg cgaggacgcc aagcccggcc agttcccctg gcaggtggtg ctgaacggca     2580

aggtggacgc cttctgcggc ggcagcatcg tgaacgagaa gtggatcgtg accgccgccc     2640

actgcgtgga gaccggcgtg aagatcaccg tggtggccgg cgagcacaac atcgaggaga     2700

ccgagcacac cgagcagaag cgcaacgtga tccgcatcat cccccaccac aactacaacg     2760

ccgccatcaa caagtacaac cacgacatcg ccctgctgga gctggacgag cccctggtgc     2820

tgaacagcta cgtgaccccc atctgcatcg ccgacaagga gtacaccaac atcttcctga     2880

agttcggcag cggctacgtg agcggctggg gccgcgtgtt ccacaagggc cgcagcgccc     2940

tggtgctgca gtacctgcgc gtgcccctgg tggaccgcgc cacctgcctg ctgagcacca     3000

agttcaccat ctacaacaac atgttctgcg ccggcttcca cgagggcggc cgcgacagct     3060

gccagggcga cagcggcggc ccccacgtga ccgaggtgga gggcaccagc ttcctgaccg     3120

gcatcatcag ctggggcgag gagtgcgcca tgaagggcaa gtacggcatc tacaccaagg     3180

tgagccgcta cgtgaactgg atcaaggaga agaccaagct gacctaatga aagatggatt     3240

tccaaggtta attcattgga attgaaaatt aacagccccc cccccccccc ccctgcagat     3300

ctgagccgaa ttcctgcagc ccgggggatc agcctcgact gtgccttcta gttgccagcc     3360

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     3420

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     3480

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     3540

tggggatgcg gtgggctcta tggcttctga ggcggaaaga accagctggg gaccggtgga     3600

tctcgatagc aggcatgctg gggagagatc gatctgagga acccctagtg atggagttgg     3660

ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc     3720

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     3780

accccccccc cccccccccc cggcgattct cttgtttgct ccagactctc aggcaatgac     3840

ctgatagcct ttgtagagac ctctcaaaaa tagctaccct ctccggcatg aatttatcag     3900

ctagaacggt tgaatatcat attgatggtg atttgactgt ctccggcctt tctcacccgt     3960

ttgaatcttt acctacacat tactcaggca ttgcatttaa aatatatgag ggttctaaaa     4020

atttttatcc ttgcgttgaa ataaaggctt ctcccgcaaa agtattacag ggtcataatg     4080

tttttggtac aaccgattta gctttatgct ctgaggcttt attgcttaat tttgctaatt     4140

ctttgccttg cctgtatgat ttattggatg ttggaatcgc ctgatgcggt attttctcct     4200

tacgcatctg tgcggtattt cacaccgcat atggtgcact ctcagtacaa tctgctctga     4260

tgccgcatag ttatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc     4320

cagccccgac acccgccaac acagccagcc ccgacacccg ccaacacccg ctgacgcgcc     4380

ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag     4440

ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt     4500

gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg     4560

cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa     4620

tatgtatccg ctcatgagac aataaccctg ataaatgctc aataatattg aaaaaggaag     4680

agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt     4740

cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt     4800

gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc     4860

cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta     4920

tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac     4980

ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa     5040

ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg     5100

atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc     5160

cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg     5220

atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta     5280

gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg     5340

cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg     5400

tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc     5460

tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt     5520

gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt     5580

gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc     5640

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     5700

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     5760

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     5820

aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag     5880

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     5940

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     6000

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     6060

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc     6120

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     6180

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     6240

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     6300

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     6360

atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga     6420

gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg     6480

gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatg         6536


<210>  42
<211>  6636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE10-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  42
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggttctatca ttatcttcaa tcagaaactg atgtgtgggg aggtgatgta tcataactca     1140

tccagggtca ggcagctgga tttgaacctg cctgaccctt agatttgagg ttttctggct     1200

ccagaatctt ctctgaagtg aaaggcatga ggccgaccac tccctgatct ggtaaacaga     1260

gatgtcagcc tggtttctag tgttagggag tttcctggag tgatggtaca gggtacattt     1320

ctgccctgca tcccaagtcc agagactggg ttctaggtcc agcctttctt ctaactccct     1380

gagagatgac agcctctggg caaagtccct ctgtgctctt cagtctcttc atctgtgaga     1440

tggtggcatg gggagaggct ggagtgatgt cacagttcct ctcagcctgg tacccactgg     1500

gaggatgttg agtaagatgg aaaactactg atgacccttg cagagacaga gtattaggac     1560

atgtttgaac aggggccggg cgatcagcag gtagctctag aggatccccg tctgtctgca     1620

catttcgtag agcgagtgtt ccgatactct aatctcccta ggcaaggttc atatttgtgt     1680

aggttactta ttctcctttt gttgactaag tcaataatca gaatcagcag gtttggagtc     1740

agcttggcag ggatcagcag cctgggttgg aaggaggggg tataaaagcc ccttcaccag     1800

gagaagccgt cacacagatc cacaagctcc tggctagaaa gaggtaaggg tttaagggat     1860

ggttggttgg tggggtatta atgtttaatt acctggagca cctgcctgaa atcacttttt     1920

ttcaggttgg gctagcccac catgcagcgc gtgaacatga tcatggccga gagccccggc     1980

ctgatcacca tctgcctgct gggctacctg ctgagcgccg agtgcaccgt gttcctggac     2040

cacgagaacg ccaacaagat cctgaaccgc cccaagcgct acaacagcgg caagctggag     2100

gagttcgtgc agggcaacct ggagcgcgag tgcatggagg agaagtgcag cttcgaggag     2160

gcccgcgagg tgttcgagaa caccgagcgc accaccgagt tctggaagca gtacgtggac     2220

ggcgaccagt gcgagagcaa cccctgcctg aacggcggca gctgcaagga cgacatcaac     2280

agctacgagt gctggtgccc cttcggcttc gagggcaaga actgcgagct ggacgtgacc     2340

tgcaacatca agaacggccg ctgcgagcag ttctgcaaga acagcgccga caacaaggtg     2400

gtgtgcagct gcaccgaggg ctaccgcctg gccgagaacc agaagagctg cgagcccgcc     2460

gtgcccttcc cctgcggccg cgtgagcgtg agccagacca gcaagctgac ccgcgccgag     2520

gccgtgttcc ccgacgtgga ctacgtgaac agcaccgagg ccgagaccat cctggacaac     2580

atcacccaga gcacccagag cttcaacgac ttcacccgcg tggtgggcgg cgaggacgcc     2640

aagcccggcc agttcccctg gcaggtggtg ctgaacggca aggtggacgc cttctgcggc     2700

ggcagcatcg tgaacgagaa gtggatcgtg accgccgccc actgcgtgga gaccggcgtg     2760

aagatcaccg tggtggccgg cgagcacaac atcgaggaga ccgagcacac cgagcagaag     2820

cgcaacgtga tccgcatcat cccccaccac aactacaacg ccgccatcaa caagtacaac     2880

cacgacatcg ccctgctgga gctggacgag cccctggtgc tgaacagcta cgtgaccccc     2940

atctgcatcg ccgacaagga gtacaccaac atcttcctga agttcggcag cggctacgtg     3000

agcggctggg gccgcgtgtt ccacaagggc cgcagcgccc tggtgctgca gtacctgcgc     3060

gtgcccctgg tggaccgcgc cacctgcctg ctgagcacca agttcaccat ctacaacaac     3120

atgttctgcg ccggcttcca cgagggcggc cgcgacagct gccagggcga cagcggcggc     3180

ccccacgtga ccgaggtgga gggcaccagc ttcctgaccg gcatcatcag ctggggcgag     3240

gagtgcgcca tgaagggcaa gtacggcatc tacaccaagg tgagccgcta cgtgaactgg     3300

atcaaggaga agaccaagct gacctaatga aagatggatt tccaaggtta attcattgga     3360

attgaaaatt aacagccccc cccccccccc ccctgcagat ctgagccgaa ttcctgcagc     3420

ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc     3480

ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg     3540

aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg     3600

acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta     3660

tggcttctga ggcggaaaga accagctggg gaccggtgga tctcgatagc aggcatgctg     3720

gggagagatc gatctgagga acccctagtg atggagttgg ccactccctc tctgcgcgct     3780

cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg     3840

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca accccccccc cccccccccc     3900

cggcgattct cttgtttgct ccagactctc aggcaatgac ctgatagcct ttgtagagac     3960

ctctcaaaaa tagctaccct ctccggcatg aatttatcag ctagaacggt tgaatatcat     4020

attgatggtg atttgactgt ctccggcctt tctcacccgt ttgaatcttt acctacacat     4080

tactcaggca ttgcatttaa aatatatgag ggttctaaaa atttttatcc ttgcgttgaa     4140

ataaaggctt ctcccgcaaa agtattacag ggtcataatg tttttggtac aaccgattta     4200

gctttatgct ctgaggcttt attgcttaat tttgctaatt ctttgccttg cctgtatgat     4260

ttattggatg ttggaatcgc ctgatgcggt attttctcct tacgcatctg tgcggtattt     4320

cacaccgcat atggtgcact ctcagtacaa tctgctctga tgccgcatag ttatatggtg     4380

cactctcagt acaatctgct ctgatgccgc atagttaagc cagccccgac acccgccaac     4440

acagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc     4500

cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt     4560

caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg     4620

ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc     4680

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac     4740

aataaccctg ataaatgctc aataatattg aaaaaggaag agtatgagta ttcaacattt     4800

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga     4860

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga     4920

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat     4980

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca     5040

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt     5100

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac     5160

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct     5220

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga     5280

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac     5340

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat     5400

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg     5460

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc     5520

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc     5580

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg     5640

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta     5700

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     5760

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     5820

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     5880

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     5940

agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa     6000

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     6060

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     6120

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     6180

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa     6240

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     6300

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     6360

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     6420

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc     6480

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag     6540

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa     6600

accgcctctc cccgcgcgtt ggccgattca ttaatg                               6636


<210>  43
<211>  6734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE11-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  43
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggacaaaagc tgcagcaaaa ttgccaaaag taggaactac tgggggtggg ggtcctgtct     1140

cccctgctca gtcaccacct cccctcccta actctcattc tggctcatac cacgtgctcc     1200

cagaagaaac gttctgagca ggggctggta tgagactgcc tcccctccca ggacccactc     1260

ctccctatga ccaggctggt gaccctccct ctagggtgcc agtgccattc actgagcaga     1320

tgtttggcag gtgtctgtta tgtgccagac ctagcagggg acagagtcct cccgatacag     1380

atggaccagt atgtttggac ataaattgtg aaaggagttg ctaatctttc tgtgcaaaat     1440

ccactcttgc ggtcaccgcc aacactccta cacatgtcag ggcatccagg gccaggactt     1500

ggtaaccctg ttcaggagca gtcgctctgg agactcccaa gacgagggaa agaaatgggt     1560

ggaaacaggg gcctacactg tgggccggta cccactggga ggatgttgag taagatggaa     1620

aactactgat gacccttgca gagacagagt attaggacat gtttgaacag gggccgggcg     1680

atcagcaggt agctctagag gatccccgtc tgtctgcaca tttcgtagag cgagtgttcc     1740

gatactctaa tctccctagg caaggttcat atttgtgtag gttacttatt ctccttttgt     1800

tgactaagtc aataatcaga atcagcaggt ttggagtcag cttggcaggg atcagcagcc     1860

tgggttggaa ggagggggta taaaagcccc ttcaccagga gaagccgtca cacagatcca     1920

caagctcctg gctagaaaga ggtaagggtt taagggatgg ttggttggtg gggtattaat     1980

gtttaattac ctggagcacc tgcctgaaat cacttttttt caggttgggc tagcccacca     2040

tgcagcgcgt gaacatgatc atggccgaga gccccggcct gatcaccatc tgcctgctgg     2100

gctacctgct gagcgccgag tgcaccgtgt tcctggacca cgagaacgcc aacaagatcc     2160

tgaaccgccc caagcgctac aacagcggca agctggagga gttcgtgcag ggcaacctgg     2220

agcgcgagtg catggaggag aagtgcagct tcgaggaggc ccgcgaggtg ttcgagaaca     2280

ccgagcgcac caccgagttc tggaagcagt acgtggacgg cgaccagtgc gagagcaacc     2340

cctgcctgaa cggcggcagc tgcaaggacg acatcaacag ctacgagtgc tggtgcccct     2400

tcggcttcga gggcaagaac tgcgagctgg acgtgacctg caacatcaag aacggccgct     2460

gcgagcagtt ctgcaagaac agcgccgaca acaaggtggt gtgcagctgc accgagggct     2520

accgcctggc cgagaaccag aagagctgcg agcccgccgt gcccttcccc tgcggccgcg     2580

tgagcgtgag ccagaccagc aagctgaccc gcgccgaggc cgtgttcccc gacgtggact     2640

acgtgaacag caccgaggcc gagaccatcc tggacaacat cacccagagc acccagagct     2700

tcaacgactt cacccgcgtg gtgggcggcg aggacgccaa gcccggccag ttcccctggc     2760

aggtggtgct gaacggcaag gtggacgcct tctgcggcgg cagcatcgtg aacgagaagt     2820

ggatcgtgac cgccgcccac tgcgtggaga ccggcgtgaa gatcaccgtg gtggccggcg     2880

agcacaacat cgaggagacc gagcacaccg agcagaagcg caacgtgatc cgcatcatcc     2940

cccaccacaa ctacaacgcc gccatcaaca agtacaacca cgacatcgcc ctgctggagc     3000

tggacgagcc cctggtgctg aacagctacg tgacccccat ctgcatcgcc gacaaggagt     3060

acaccaacat cttcctgaag ttcggcagcg gctacgtgag cggctggggc cgcgtgttcc     3120

acaagggccg cagcgccctg gtgctgcagt acctgcgcgt gcccctggtg gaccgcgcca     3180

cctgcctgct gagcaccaag ttcaccatct acaacaacat gttctgcgcc ggcttccacg     3240

agggcggccg cgacagctgc cagggcgaca gcggcggccc ccacgtgacc gaggtggagg     3300

gcaccagctt cctgaccggc atcatcagct ggggcgagga gtgcgccatg aagggcaagt     3360

acggcatcta caccaaggtg agccgctacg tgaactggat caaggagaag accaagctga     3420

cctaatgaaa gatggatttc caaggttaat tcattggaat tgaaaattaa cagccccccc     3480

cccccccccc ctgcagatct gagccgaatt cctgcagccc gggggatcag cctcgactgt     3540

gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga     3600

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag     3660

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     3720

agacaatagc aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac     3780

cagctgggga ccggtggatc tcgatagcag gcatgctggg gagagatcga tctgaggaac     3840

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgccc     3900

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     3960

gcagagaggg agtggccaac cccccccccc cccccccccg gcgattctct tgtttgctcc     4020

agactctcag gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct     4080

ccggcatgaa tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct     4140

ccggcctttc tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa     4200

tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag     4260

tattacaggg tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat     4320

tgcttaattt tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct     4380

gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct     4440

cagtacaatc tgctctgatg ccgcatagtt atatggtgca ctctcagtac aatctgctct     4500

gatgccgcat agttaagcca gccccgacac ccgccaacac agccagcccc gacacccgcc     4560

aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc     4620

tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc     4680

gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt     4740

ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt     4800

tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgctcaa     4860

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     4920

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     4980

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     5040

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     5100

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     5160

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     5220

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     5280

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     5340

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     5400

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     5460

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     5520

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     5580

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     5640

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     5700

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     5760

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     5820

atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg     5880

tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc     5940

tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag     6000

ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc     6060

cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac     6120

ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc     6180

gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt     6240

tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt     6300

gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc     6360

ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt     6420

tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca     6480

ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt     6540

tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt     6600

attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag     6660

tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg     6720

ccgattcatt aatg                                                       6734


<210>  44
<211>  6661
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE12-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  44
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

gggtgaggcc acggtcttcc cgccaggttg actcgagcct cctgccagag ccactggccc     1140

cggaggccac cctagaccgc agctggcggc cgctggcacg agtgcagggt aactgagcca     1200

gggccgctgg cgcatttggc ctggccgagg ccaccccgcg cggccgctcc actgtgcccg     1260

aggctgtcct ggaggtgagg ccggcccaca gggaccctgc ccgtgcccgg gctccggtga     1320

gtcagggcgc gttatgcaag tgcccccggc gcctcccctt cggtctttca ccccgcgcgg     1380

ttacgaaagc gcgaccccct ccccccggcg ctataaagca gcggggcggc cgcggcgcgc     1440

tcgcctccct cgctccacgc gcgcccggac tcggcggcca ggcttgcgcg cggttcccct     1500

cccggtggtg agtggtaccc actgggagga tgttgagtaa gatggaaaac tactgatgac     1560

ccttgcagag acagagtatt aggacatgtt tgaacagggg ccgggcgatc agcaggtagc     1620

tctagaggat ccccgtctgt ctgcacattt cgtagagcga gtgttccgat actctaatct     1680

ccctaggcaa ggttcatatt tgtgtaggtt acttattctc cttttgttga ctaagtcaat     1740

aatcagaatc agcaggtttg gagtcagctt ggcagggatc agcagcctgg gttggaagga     1800

gggggtataa aagccccttc accaggagaa gccgtcacac agatccacaa gctcctggct     1860

agaaagaggt aagggtttaa gggatggttg gttggtgggg tattaatgtt taattacctg     1920

gagcacctgc ctgaaatcac tttttttcag gttgggctag cccaccatgc agcgcgtgaa     1980

catgatcatg gccgagagcc ccggcctgat caccatctgc ctgctgggct acctgctgag     2040

cgccgagtgc accgtgttcc tggaccacga gaacgccaac aagatcctga accgccccaa     2100

gcgctacaac agcggcaagc tggaggagtt cgtgcagggc aacctggagc gcgagtgcat     2160

ggaggagaag tgcagcttcg aggaggcccg cgaggtgttc gagaacaccg agcgcaccac     2220

cgagttctgg aagcagtacg tggacggcga ccagtgcgag agcaacccct gcctgaacgg     2280

cggcagctgc aaggacgaca tcaacagcta cgagtgctgg tgccccttcg gcttcgaggg     2340

caagaactgc gagctggacg tgacctgcaa catcaagaac ggccgctgcg agcagttctg     2400

caagaacagc gccgacaaca aggtggtgtg cagctgcacc gagggctacc gcctggccga     2460

gaaccagaag agctgcgagc ccgccgtgcc cttcccctgc ggccgcgtga gcgtgagcca     2520

gaccagcaag ctgacccgcg ccgaggccgt gttccccgac gtggactacg tgaacagcac     2580

cgaggccgag accatcctgg acaacatcac ccagagcacc cagagcttca acgacttcac     2640

ccgcgtggtg ggcggcgagg acgccaagcc cggccagttc ccctggcagg tggtgctgaa     2700

cggcaaggtg gacgccttct gcggcggcag catcgtgaac gagaagtgga tcgtgaccgc     2760

cgcccactgc gtggagaccg gcgtgaagat caccgtggtg gccggcgagc acaacatcga     2820

ggagaccgag cacaccgagc agaagcgcaa cgtgatccgc atcatccccc accacaacta     2880

caacgccgcc atcaacaagt acaaccacga catcgccctg ctggagctgg acgagcccct     2940

ggtgctgaac agctacgtga cccccatctg catcgccgac aaggagtaca ccaacatctt     3000

cctgaagttc ggcagcggct acgtgagcgg ctggggccgc gtgttccaca agggccgcag     3060

cgccctggtg ctgcagtacc tgcgcgtgcc cctggtggac cgcgccacct gcctgctgag     3120

caccaagttc accatctaca acaacatgtt ctgcgccggc ttccacgagg gcggccgcga     3180

cagctgccag ggcgacagcg gcggccccca cgtgaccgag gtggagggca ccagcttcct     3240

gaccggcatc atcagctggg gcgaggagtg cgccatgaag ggcaagtacg gcatctacac     3300

caaggtgagc cgctacgtga actggatcaa ggagaagacc aagctgacct aatgaaagat     3360

ggatttccaa ggttaattca ttggaattga aaattaacag cccccccccc cccccccctg     3420

cagatctgag ccgaattcct gcagcccggg ggatcagcct cgactgtgcc ttctagttgc     3480

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     3540

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     3600

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     3660

catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggaccg     3720

gtggatctcg atagcaggca tgctggggag agatcgatct gaggaacccc tagtgatgga     3780

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg     3840

gcgtcgggcg acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt     3900

ggccaacccc cccccccccc ccccccggcg attctcttgt ttgctccaga ctctcaggca     3960

atgacctgat agcctttgta gagacctctc aaaaatagct accctctccg gcatgaattt     4020

atcagctaga acggttgaat atcatattga tggtgatttg actgtctccg gcctttctca     4080

cccgtttgaa tctttaccta cacattactc aggcattgca tttaaaatat atgagggttc     4140

taaaaatttt tatccttgcg ttgaaataaa ggcttctccc gcaaaagtat tacagggtca     4200

taatgttttt ggtacaaccg atttagcttt atgctctgag gctttattgc ttaattttgc     4260

taattctttg ccttgcctgt atgatttatt ggatgttgga atcgcctgat gcggtatttt     4320

ctccttacgc atctgtgcgg tatttcacac cgcatatggt gcactctcag tacaatctgc     4380

tctgatgccg catagttata tggtgcactc tcagtacaat ctgctctgat gccgcatagt     4440

taagccagcc ccgacacccg ccaacacagc cagccccgac acccgccaac acccgctgac     4500

gcgccctgac gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc     4560

gggagctgca tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc     4620

ctcgtgatac gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca     4680

ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat     4740

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgctcaataa tattgaaaaa     4800

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt     4860

gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt     4920

tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt     4980

ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg     5040

tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga     5100

atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa     5160

gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga     5220

caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa     5280

ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca     5340

ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta     5400

ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac     5460

ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc     5520

gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag     5580

ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga     5640

taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt     5700

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata     5760

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag     5820

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa     5880

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt     5940

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc     6000

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa     6060

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa     6120

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc     6180

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa     6240

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa     6300

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg     6360

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc     6420

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg     6480

ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg     6540

agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg     6600

aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat     6660

g                                                                     6661


<210>  45
<211>  6678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE13-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  45
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggaaatacct aaactagtca cactgttttg attcaattgg ctactgaagt tatagaatgt     1140

tgtttactct tctctccttt gtctactccc cagccaacaa aacaaccgac cttagctgtt     1200

ttgaaaataa atgaaaattc caacatgggt ttgaaataaa attgcatcat aaacaatcgg     1260

taggtgtttt tcaaagtggt ttcagggaag tgccacggag taagcaggcg accaccgagg     1320

ctgctaaaat atttcctgtc ctgaccaggg ttgcgtttct ggagaatatt taacagggag     1380

ggttttaacg cttttaaaga tgttgaaact aaagaacaaa tattgaccag agggcaccac     1440

aacgctcctg aaagagagta aaatacatcc tttataaaat gaaaaactac ttggatgaat     1500

tattccaaaa ttcctgcaca agtggacctc ggtacccact gggaggatgt tgagtaagat     1560

ggaaaactac tgatgaccct tgcagagaca gagtattagg acatgtttga acaggggccg     1620

ggcgatcagc aggtagctct agaggatccc cgtctgtctg cacatttcgt agagcgagtg     1680

ttccgatact ctaatctccc taggcaaggt tcatatttgt gtaggttact tattctcctt     1740

ttgttgacta agtcaataat cagaatcagc aggtttggag tcagcttggc agggatcagc     1800

agcctgggtt ggaaggaggg ggtataaaag ccccttcacc aggagaagcc gtcacacaga     1860

tccacaagct cctggctaga aagaggtaag ggtttaaggg atggttggtt ggtggggtat     1920

taatgtttaa ttacctggag cacctgcctg aaatcacttt ttttcaggtt gggctagccc     1980

accatgcagc gcgtgaacat gatcatggcc gagagccccg gcctgatcac catctgcctg     2040

ctgggctacc tgctgagcgc cgagtgcacc gtgttcctgg accacgagaa cgccaacaag     2100

atcctgaacc gccccaagcg ctacaacagc ggcaagctgg aggagttcgt gcagggcaac     2160

ctggagcgcg agtgcatgga ggagaagtgc agcttcgagg aggcccgcga ggtgttcgag     2220

aacaccgagc gcaccaccga gttctggaag cagtacgtgg acggcgacca gtgcgagagc     2280

aacccctgcc tgaacggcgg cagctgcaag gacgacatca acagctacga gtgctggtgc     2340

cccttcggct tcgagggcaa gaactgcgag ctggacgtga cctgcaacat caagaacggc     2400

cgctgcgagc agttctgcaa gaacagcgcc gacaacaagg tggtgtgcag ctgcaccgag     2460

ggctaccgcc tggccgagaa ccagaagagc tgcgagcccg ccgtgccctt cccctgcggc     2520

cgcgtgagcg tgagccagac cagcaagctg acccgcgccg aggccgtgtt ccccgacgtg     2580

gactacgtga acagcaccga ggccgagacc atcctggaca acatcaccca gagcacccag     2640

agcttcaacg acttcacccg cgtggtgggc ggcgaggacg ccaagcccgg ccagttcccc     2700

tggcaggtgg tgctgaacgg caaggtggac gccttctgcg gcggcagcat cgtgaacgag     2760

aagtggatcg tgaccgccgc ccactgcgtg gagaccggcg tgaagatcac cgtggtggcc     2820

ggcgagcaca acatcgagga gaccgagcac accgagcaga agcgcaacgt gatccgcatc     2880

atcccccacc acaactacaa cgccgccatc aacaagtaca accacgacat cgccctgctg     2940

gagctggacg agcccctggt gctgaacagc tacgtgaccc ccatctgcat cgccgacaag     3000

gagtacacca acatcttcct gaagttcggc agcggctacg tgagcggctg gggccgcgtg     3060

ttccacaagg gccgcagcgc cctggtgctg cagtacctgc gcgtgcccct ggtggaccgc     3120

gccacctgcc tgctgagcac caagttcacc atctacaaca acatgttctg cgccggcttc     3180

cacgagggcg gccgcgacag ctgccagggc gacagcggcg gcccccacgt gaccgaggtg     3240

gagggcacca gcttcctgac cggcatcatc agctggggcg aggagtgcgc catgaagggc     3300

aagtacggca tctacaccaa ggtgagccgc tacgtgaact ggatcaagga gaagaccaag     3360

ctgacctaat gaaagatgga tttccaaggt taattcattg gaattgaaaa ttaacagccc     3420

cccccccccc ccccctgcag atctgagccg aattcctgca gcccggggga tcagcctcga     3480

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     3540

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc     3600

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt     3660

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa     3720

gaaccagctg gggaccggtg gatctcgata gcaggcatgc tggggagaga tcgatctgag     3780

gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc     3840

gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga     3900

gcgcgcagag agggagtggc caaccccccc cccccccccc cccggcgatt ctcttgtttg     3960

ctccagactc tcaggcaatg acctgatagc ctttgtagag acctctcaaa aatagctacc     4020

ctctccggca tgaatttatc agctagaacg gttgaatatc atattgatgg tgatttgact     4080

gtctccggcc tttctcaccc gtttgaatct ttacctacac attactcagg cattgcattt     4140

aaaatatatg agggttctaa aaatttttat ccttgcgttg aaataaaggc ttctcccgca     4200

aaagtattac agggtcataa tgtttttggt acaaccgatt tagctttatg ctctgaggct     4260

ttattgctta attttgctaa ttctttgcct tgcctgtatg atttattgga tgttggaatc     4320

gcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atatggtgca     4380

ctctcagtac aatctgctct gatgccgcat agttatatgg tgcactctca gtacaatctg     4440

ctctgatgcc gcatagttaa gccagccccg acacccgcca acacagccag ccccgacacc     4500

cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac     4560

aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac     4620

gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc atgataataa     4680

tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt     4740

tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc     4800

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc     4860

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     4920

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     4980

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     5040

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     5100

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     5160

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     5220

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     5280

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     5340

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     5400

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     5460

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     5520

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     5580

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     5640

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     5700

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     5760

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     5820

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     5880

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     5940

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     6000

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     6060

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     6120

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     6180

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     6240

gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     6300

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     6360

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     6420

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     6480

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     6540

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     6600

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     6660

ttggccgatt cattaatg                                                   6678


<210>  46
<211>  6565
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE14-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  46
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggctgagctc atctgggctg cagggctggc gggacagcag cgtggactca gtctcctagg     1140

gatttcccaa ctctcccgcc cgcttgctgc atctggacac cctgcctcag gccctcatct     1200

ccactggtca gcaggtgacc tttgcccagc gccctgggtc ctcagtgcct gctgccctgg     1260

agatgatata aaacaggtca gaaccctcct gcctgtctgc tcagttcatc cctagaggca     1320

gctgctccag gtaatgccct ctggggaggg gaaagaggag gggaggagga tgaagagggg     1380

caagaggagc tccctgccca gcccagccag caagcctggt acccactggg aggatgttga     1440

gtaagatgga aaactactga tgacccttgc agagacagag tattaggaca tgtttgaaca     1500

ggggccgggc gatcagcagg tagctctaga ggatccccgt ctgtctgcac atttcgtaga     1560

gcgagtgttc cgatactcta atctccctag gcaaggttca tatttgtgta ggttacttat     1620

tctccttttg ttgactaagt caataatcag aatcagcagg tttggagtca gcttggcagg     1680

gatcagcagc ctgggttgga aggagggggt ataaaagccc cttcaccagg agaagccgtc     1740

acacagatcc acaagctcct ggctagaaag aggtaagggt ttaagggatg gttggttggt     1800

ggggtattaa tgtttaatta cctggagcac ctgcctgaaa tcactttttt tcaggttggg     1860

ctagcccacc atgcagcgcg tgaacatgat catggccgag agccccggcc tgatcaccat     1920

ctgcctgctg ggctacctgc tgagcgccga gtgcaccgtg ttcctggacc acgagaacgc     1980

caacaagatc ctgaaccgcc ccaagcgcta caacagcggc aagctggagg agttcgtgca     2040

gggcaacctg gagcgcgagt gcatggagga gaagtgcagc ttcgaggagg cccgcgaggt     2100

gttcgagaac accgagcgca ccaccgagtt ctggaagcag tacgtggacg gcgaccagtg     2160

cgagagcaac ccctgcctga acggcggcag ctgcaaggac gacatcaaca gctacgagtg     2220

ctggtgcccc ttcggcttcg agggcaagaa ctgcgagctg gacgtgacct gcaacatcaa     2280

gaacggccgc tgcgagcagt tctgcaagaa cagcgccgac aacaaggtgg tgtgcagctg     2340

caccgagggc taccgcctgg ccgagaacca gaagagctgc gagcccgccg tgcccttccc     2400

ctgcggccgc gtgagcgtga gccagaccag caagctgacc cgcgccgagg ccgtgttccc     2460

cgacgtggac tacgtgaaca gcaccgaggc cgagaccatc ctggacaaca tcacccagag     2520

cacccagagc ttcaacgact tcacccgcgt ggtgggcggc gaggacgcca agcccggcca     2580

gttcccctgg caggtggtgc tgaacggcaa ggtggacgcc ttctgcggcg gcagcatcgt     2640

gaacgagaag tggatcgtga ccgccgccca ctgcgtggag accggcgtga agatcaccgt     2700

ggtggccggc gagcacaaca tcgaggagac cgagcacacc gagcagaagc gcaacgtgat     2760

ccgcatcatc ccccaccaca actacaacgc cgccatcaac aagtacaacc acgacatcgc     2820

cctgctggag ctggacgagc ccctggtgct gaacagctac gtgaccccca tctgcatcgc     2880

cgacaaggag tacaccaaca tcttcctgaa gttcggcagc ggctacgtga gcggctgggg     2940

ccgcgtgttc cacaagggcc gcagcgccct ggtgctgcag tacctgcgcg tgcccctggt     3000

ggaccgcgcc acctgcctgc tgagcaccaa gttcaccatc tacaacaaca tgttctgcgc     3060

cggcttccac gagggcggcc gcgacagctg ccagggcgac agcggcggcc cccacgtgac     3120

cgaggtggag ggcaccagct tcctgaccgg catcatcagc tggggcgagg agtgcgccat     3180

gaagggcaag tacggcatct acaccaaggt gagccgctac gtgaactgga tcaaggagaa     3240

gaccaagctg acctaatgaa agatggattt ccaaggttaa ttcattggaa ttgaaaatta     3300

acagcccccc cccccccccc cctgcagatc tgagccgaat tcctgcagcc cgggggatca     3360

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     3420

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     3480

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     3540

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     3600

gcggaaagaa ccagctgggg accggtggat ctcgatagca ggcatgctgg ggagagatcg     3660

atctgaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     3720

tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt ggtcgcccgg cctcagtgag     3780

cgagcgagcg cgcagagagg gagtggccaa cccccccccc cccccccccc ggcgattctc     3840

ttgtttgctc cagactctca ggcaatgacc tgatagcctt tgtagagacc tctcaaaaat     3900

agctaccctc tccggcatga atttatcagc tagaacggtt gaatatcata ttgatggtga     3960

tttgactgtc tccggccttt ctcacccgtt tgaatcttta cctacacatt actcaggcat     4020

tgcatttaaa atatatgagg gttctaaaaa tttttatcct tgcgttgaaa taaaggcttc     4080

tcccgcaaaa gtattacagg gtcataatgt ttttggtaca accgatttag ctttatgctc     4140

tgaggcttta ttgcttaatt ttgctaattc tttgccttgc ctgtatgatt tattggatgt     4200

tggaatcgcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata     4260

tggtgcactc tcagtacaat ctgctctgat gccgcatagt tatatggtgc actctcagta     4320

caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca cagccagccc     4380

cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct     4440

tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca     4500

ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg     4560

ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct     4620

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     4680

taaatgctca ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc     4740

ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga     4800

aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca     4860

acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt     4920

ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg     4980

gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc     5040

atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata     5100

acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt     5160

tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag     5220

ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca     5280

aactattaac tggcgaacta cttactctag cttcccggca acaattaata gactggatgg     5340

aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg     5400

ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag     5460

atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg     5520

aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag     5580

accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga     5640

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     5700

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     5760

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     5820

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     5880

caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     5940

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     6000

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     6060

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     6120

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     6180

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     6240

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     6300

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     6360

tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg     6420

tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg     6480

agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc     6540

ccgcgcgttg gccgattcat taatg                                           6565


<210>  47
<211>  6661
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE15-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  47
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggagaagggt cagcggcccc tcctggacca ccgactcccc gcagaactcc tctgtgccct     1140

ctcctcacca gaccttgttc ctcccagttg ctcccacagc cagggggcag tgagggctgc     1200

tcttccccca gccccactga ggaacccagg aaggtgaacg agagaatcag tcctggtggg     1260

ggctggggag ggccccagac atgagaccag ctcctccccc aggggatgtt atcagtgggt     1320

ccagagggca aaatagggag cctggtggag ggaggggcaa aggcctcggg ctctgagcgg     1380

ccttggccct tctccaccaa cccctgccct acactaaggg ggaggcagcg gggggcacac     1440

agggtggggg cgggtggggg gctgctgggt gagcagcact cgcctgcctg gattgaaacc     1500

cagagatgga ggtggtaccc actgggagga tgttgagtaa gatggaaaac tactgatgac     1560

ccttgcagag acagagtatt aggacatgtt tgaacagggg ccgggcgatc agcaggtagc     1620

tctagaggat ccccgtctgt ctgcacattt cgtagagcga gtgttccgat actctaatct     1680

ccctaggcaa ggttcatatt tgtgtaggtt acttattctc cttttgttga ctaagtcaat     1740

aatcagaatc agcaggtttg gagtcagctt ggcagggatc agcagcctgg gttggaagga     1800

gggggtataa aagccccttc accaggagaa gccgtcacac agatccacaa gctcctggct     1860

agaaagaggt aagggtttaa gggatggttg gttggtgggg tattaatgtt taattacctg     1920

gagcacctgc ctgaaatcac tttttttcag gttgggctag cccaccatgc agcgcgtgaa     1980

catgatcatg gccgagagcc ccggcctgat caccatctgc ctgctgggct acctgctgag     2040

cgccgagtgc accgtgttcc tggaccacga gaacgccaac aagatcctga accgccccaa     2100

gcgctacaac agcggcaagc tggaggagtt cgtgcagggc aacctggagc gcgagtgcat     2160

ggaggagaag tgcagcttcg aggaggcccg cgaggtgttc gagaacaccg agcgcaccac     2220

cgagttctgg aagcagtacg tggacggcga ccagtgcgag agcaacccct gcctgaacgg     2280

cggcagctgc aaggacgaca tcaacagcta cgagtgctgg tgccccttcg gcttcgaggg     2340

caagaactgc gagctggacg tgacctgcaa catcaagaac ggccgctgcg agcagttctg     2400

caagaacagc gccgacaaca aggtggtgtg cagctgcacc gagggctacc gcctggccga     2460

gaaccagaag agctgcgagc ccgccgtgcc cttcccctgc ggccgcgtga gcgtgagcca     2520

gaccagcaag ctgacccgcg ccgaggccgt gttccccgac gtggactacg tgaacagcac     2580

cgaggccgag accatcctgg acaacatcac ccagagcacc cagagcttca acgacttcac     2640

ccgcgtggtg ggcggcgagg acgccaagcc cggccagttc ccctggcagg tggtgctgaa     2700

cggcaaggtg gacgccttct gcggcggcag catcgtgaac gagaagtgga tcgtgaccgc     2760

cgcccactgc gtggagaccg gcgtgaagat caccgtggtg gccggcgagc acaacatcga     2820

ggagaccgag cacaccgagc agaagcgcaa cgtgatccgc atcatccccc accacaacta     2880

caacgccgcc atcaacaagt acaaccacga catcgccctg ctggagctgg acgagcccct     2940

ggtgctgaac agctacgtga cccccatctg catcgccgac aaggagtaca ccaacatctt     3000

cctgaagttc ggcagcggct acgtgagcgg ctggggccgc gtgttccaca agggccgcag     3060

cgccctggtg ctgcagtacc tgcgcgtgcc cctggtggac cgcgccacct gcctgctgag     3120

caccaagttc accatctaca acaacatgtt ctgcgccggc ttccacgagg gcggccgcga     3180

cagctgccag ggcgacagcg gcggccccca cgtgaccgag gtggagggca ccagcttcct     3240

gaccggcatc atcagctggg gcgaggagtg cgccatgaag ggcaagtacg gcatctacac     3300

caaggtgagc cgctacgtga actggatcaa ggagaagacc aagctgacct aatgaaagat     3360

ggatttccaa ggttaattca ttggaattga aaattaacag cccccccccc cccccccctg     3420

cagatctgag ccgaattcct gcagcccggg ggatcagcct cgactgtgcc ttctagttgc     3480

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     3540

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     3600

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     3660

catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggaccg     3720

gtggatctcg atagcaggca tgctggggag agatcgatct gaggaacccc tagtgatgga     3780

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg     3840

gcgtcgggcg acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt     3900

ggccaacccc cccccccccc ccccccggcg attctcttgt ttgctccaga ctctcaggca     3960

atgacctgat agcctttgta gagacctctc aaaaatagct accctctccg gcatgaattt     4020

atcagctaga acggttgaat atcatattga tggtgatttg actgtctccg gcctttctca     4080

cccgtttgaa tctttaccta cacattactc aggcattgca tttaaaatat atgagggttc     4140

taaaaatttt tatccttgcg ttgaaataaa ggcttctccc gcaaaagtat tacagggtca     4200

taatgttttt ggtacaaccg atttagcttt atgctctgag gctttattgc ttaattttgc     4260

taattctttg ccttgcctgt atgatttatt ggatgttgga atcgcctgat gcggtatttt     4320

ctccttacgc atctgtgcgg tatttcacac cgcatatggt gcactctcag tacaatctgc     4380

tctgatgccg catagttata tggtgcactc tcagtacaat ctgctctgat gccgcatagt     4440

taagccagcc ccgacacccg ccaacacagc cagccccgac acccgccaac acccgctgac     4500

gcgccctgac gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc     4560

gggagctgca tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc     4620

ctcgtgatac gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca     4680

ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat     4740

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgctcaataa tattgaaaaa     4800

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt     4860

gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt     4920

tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt     4980

ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg     5040

tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga     5100

atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa     5160

gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga     5220

caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa     5280

ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca     5340

ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta     5400

ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac     5460

ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc     5520

gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag     5580

ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga     5640

taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt     5700

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata     5760

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag     5820

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa     5880

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt     5940

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc     6000

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa     6060

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa     6120

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc     6180

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa     6240

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa     6300

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg     6360

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc     6420

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg     6480

ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg     6540

agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg     6600

aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat     6660

g                                                                     6661


<210>  48
<211>  6789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE16-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  48
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

gggtagctga tgggaagagc agactgcctt ccagccaggc ctggtcctgt gagtcaggga     1140

cgtccatctt agtgggcatg aaaggcctgt gtgatctcga gggagacatc gcctctccaa     1200

gcctctcctt atctgtgcaa caggcagact taatgattgg tgaggcaatg aggctgatag     1260

ctcagcatta gctacagcca cccctcctgg ccaaccacac agggatcaaa ccaggggtca     1320

gtccagaggt cagagtcagg agcagacaac tcagatccag ccagggacag gcaggtcaca     1380

cggacatgtg cctcacgtat gcttcaaggg gccctccccc gggcagaact gaaggacagc     1440

tcctgttgcc ataggaggga gctgggtgag atactaggag gaacttccgg catgatgatg     1500

tgtgatgaac aagggcctct ggccaacagg tctgaatcag ggctgcccag cccagcctgg     1560

tgggaagggc atggagcatg ggggctcatg tactaaacct cacctggaca caaggtgaaa     1620

cagcccaacc ccagaggacc aggtacccac tgggaggatg ttgagtaaga tggaaaacta     1680

ctgatgaccc ttgcagagac agagtattag gacatgtttg aacaggggcc gggcgatcag     1740

caggtagctc tagaggatcc ccgtctgtct gcacatttcg tagagcgagt gttccgatac     1800

tctaatctcc ctaggcaagg ttcatatttg tgtaggttac ttattctcct tttgttgact     1860

aagtcaataa tcagaatcag caggtttgga gtcagcttgg cagggatcag cagcctgggt     1920

tggaaggagg gggtataaaa gccccttcac caggagaagc cgtcacacag atccacaagc     1980

tcctggctag aaagaggtaa gggtttaagg gatggttggt tggtggggta ttaatgttta     2040

attacctgga gcacctgcct gaaatcactt tttttcaggt tgggctagcc caccatgcag     2100

cgcgtgaaca tgatcatggc cgagagcccc ggcctgatca ccatctgcct gctgggctac     2160

ctgctgagcg ccgagtgcac cgtgttcctg gaccacgaga acgccaacaa gatcctgaac     2220

cgccccaagc gctacaacag cggcaagctg gaggagttcg tgcagggcaa cctggagcgc     2280

gagtgcatgg aggagaagtg cagcttcgag gaggcccgcg aggtgttcga gaacaccgag     2340

cgcaccaccg agttctggaa gcagtacgtg gacggcgacc agtgcgagag caacccctgc     2400

ctgaacggcg gcagctgcaa ggacgacatc aacagctacg agtgctggtg ccccttcggc     2460

ttcgagggca agaactgcga gctggacgtg acctgcaaca tcaagaacgg ccgctgcgag     2520

cagttctgca agaacagcgc cgacaacaag gtggtgtgca gctgcaccga gggctaccgc     2580

ctggccgaga accagaagag ctgcgagccc gccgtgccct tcccctgcgg ccgcgtgagc     2640

gtgagccaga ccagcaagct gacccgcgcc gaggccgtgt tccccgacgt ggactacgtg     2700

aacagcaccg aggccgagac catcctggac aacatcaccc agagcaccca gagcttcaac     2760

gacttcaccc gcgtggtggg cggcgaggac gccaagcccg gccagttccc ctggcaggtg     2820

gtgctgaacg gcaaggtgga cgccttctgc ggcggcagca tcgtgaacga gaagtggatc     2880

gtgaccgccg cccactgcgt ggagaccggc gtgaagatca ccgtggtggc cggcgagcac     2940

aacatcgagg agaccgagca caccgagcag aagcgcaacg tgatccgcat catcccccac     3000

cacaactaca acgccgccat caacaagtac aaccacgaca tcgccctgct ggagctggac     3060

gagcccctgg tgctgaacag ctacgtgacc cccatctgca tcgccgacaa ggagtacacc     3120

aacatcttcc tgaagttcgg cagcggctac gtgagcggct ggggccgcgt gttccacaag     3180

ggccgcagcg ccctggtgct gcagtacctg cgcgtgcccc tggtggaccg cgccacctgc     3240

ctgctgagca ccaagttcac catctacaac aacatgttct gcgccggctt ccacgagggc     3300

ggccgcgaca gctgccaggg cgacagcggc ggcccccacg tgaccgaggt ggagggcacc     3360

agcttcctga ccggcatcat cagctggggc gaggagtgcg ccatgaaggg caagtacggc     3420

atctacacca aggtgagccg ctacgtgaac tggatcaagg agaagaccaa gctgacctaa     3480

tgaaagatgg atttccaagg ttaattcatt ggaattgaaa attaacagcc cccccccccc     3540

cccccctgca gatctgagcc gaattcctgc agcccggggg atcagcctcg actgtgcctt     3600

ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg     3660

ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt     3720

gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca     3780

atagcaggca tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct     3840

ggggaccggt ggatctcgat agcaggcatg ctggggagag atcgatctga ggaaccccta     3900

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgcccgggca     3960

aagcccgggc gtcgggcgac ctttggtcgc ccggcctcag tgagcgagcg agcgcgcaga     4020

gagggagtgg ccaacccccc cccccccccc ccccggcgat tctcttgttt gctccagact     4080

ctcaggcaat gacctgatag cctttgtaga gacctctcaa aaatagctac cctctccggc     4140

atgaatttat cagctagaac ggttgaatat catattgatg gtgatttgac tgtctccggc     4200

ctttctcacc cgtttgaatc tttacctaca cattactcag gcattgcatt taaaatatat     4260

gagggttcta aaaattttta tccttgcgtt gaaataaagg cttctcccgc aaaagtatta     4320

cagggtcata atgtttttgg tacaaccgat ttagctttat gctctgaggc tttattgctt     4380

aattttgcta attctttgcc ttgcctgtat gatttattgg atgttggaat cgcctgatgc     4440

ggtattttct ccttacgcat ctgtgcggta tttcacaccg catatggtgc actctcagta     4500

caatctgctc tgatgccgca tagttatatg gtgcactctc agtacaatct gctctgatgc     4560

cgcatagtta agccagcccc gacacccgcc aacacagcca gccccgacac ccgccaacac     4620

ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga     4680

ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac     4740

gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt     4800

agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct     4860

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg ctcaataata     4920

ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc     4980

ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga     5040

agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct     5100

tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg     5160

tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta     5220

ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat     5280

gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt     5340

acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga     5400

tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga     5460

gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga     5520

actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc     5580

aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc     5640

cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg     5700

tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat     5760

cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata     5820

tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct     5880

ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga     5940

ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg     6000

cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc     6060

aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct     6120

agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc     6180

tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt     6240

ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg     6300

cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct     6360

atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag     6420

ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag     6480

tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg     6540

gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg     6600

gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac     6660

cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt     6720

gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat     6780

tcattaatg                                                             6789


<210>  49
<211>  6600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE17-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  49
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

gggcttgcaa caatgtctgg cacataggaa aagtgatcac taaatgttag ccacgtctta     1140

ctcctgcaag gctcacctcc ctggaaccca tcggtcccaa ccctgctcct gaatcaggca     1200

cagtccagct tgcagcggga gcaaaggtca gtactcagtg cccctgtccc ttccccaggc     1260

cagaggggag gaggagactg agtcacgaat gacacctcag ccgcagtttg acctccagga     1320

cttacagtcc tagcagccgg tgccactagc atgtgagagg tccagaggcg cttctgtctc     1380

acccgcccgc ctgggtgcac ccatgctggg agcgcctgca ccatttgagc atgtccgaga     1440

gcatccacca gaggtaccca ctgggaggat gttgagtaag atggaaaact actgatgacc     1500

cttgcagaga cagagtatta ggacatgttt gaacaggggc cgggcgatca gcaggtagct     1560

ctagaggatc cccgtctgtc tgcacatttc gtagagcgag tgttccgata ctctaatctc     1620

cctaggcaag gttcatattt gtgtaggtta cttattctcc ttttgttgac taagtcaata     1680

atcagaatca gcaggtttgg agtcagcttg gcagggatca gcagcctggg ttggaaggag     1740

ggggtataaa agccccttca ccaggagaag ccgtcacaca gatccacaag ctcctggcta     1800

gaaagaggta agggtttaag ggatggttgg ttggtggggt attaatgttt aattacctgg     1860

agcacctgcc tgaaatcact ttttttcagg ttgggctagc ccaccatgca gcgcgtgaac     1920

atgatcatgg ccgagagccc cggcctgatc accatctgcc tgctgggcta cctgctgagc     1980

gccgagtgca ccgtgttcct ggaccacgag aacgccaaca agatcctgaa ccgccccaag     2040

cgctacaaca gcggcaagct ggaggagttc gtgcagggca acctggagcg cgagtgcatg     2100

gaggagaagt gcagcttcga ggaggcccgc gaggtgttcg agaacaccga gcgcaccacc     2160

gagttctgga agcagtacgt ggacggcgac cagtgcgaga gcaacccctg cctgaacggc     2220

ggcagctgca aggacgacat caacagctac gagtgctggt gccccttcgg cttcgagggc     2280

aagaactgcg agctggacgt gacctgcaac atcaagaacg gccgctgcga gcagttctgc     2340

aagaacagcg ccgacaacaa ggtggtgtgc agctgcaccg agggctaccg cctggccgag     2400

aaccagaaga gctgcgagcc cgccgtgccc ttcccctgcg gccgcgtgag cgtgagccag     2460

accagcaagc tgacccgcgc cgaggccgtg ttccccgacg tggactacgt gaacagcacc     2520

gaggccgaga ccatcctgga caacatcacc cagagcaccc agagcttcaa cgacttcacc     2580

cgcgtggtgg gcggcgagga cgccaagccc ggccagttcc cctggcaggt ggtgctgaac     2640

ggcaaggtgg acgccttctg cggcggcagc atcgtgaacg agaagtggat cgtgaccgcc     2700

gcccactgcg tggagaccgg cgtgaagatc accgtggtgg ccggcgagca caacatcgag     2760

gagaccgagc acaccgagca gaagcgcaac gtgatccgca tcatccccca ccacaactac     2820

aacgccgcca tcaacaagta caaccacgac atcgccctgc tggagctgga cgagcccctg     2880

gtgctgaaca gctacgtgac ccccatctgc atcgccgaca aggagtacac caacatcttc     2940

ctgaagttcg gcagcggcta cgtgagcggc tggggccgcg tgttccacaa gggccgcagc     3000

gccctggtgc tgcagtacct gcgcgtgccc ctggtggacc gcgccacctg cctgctgagc     3060

accaagttca ccatctacaa caacatgttc tgcgccggct tccacgaggg cggccgcgac     3120

agctgccagg gcgacagcgg cggcccccac gtgaccgagg tggagggcac cagcttcctg     3180

accggcatca tcagctgggg cgaggagtgc gccatgaagg gcaagtacgg catctacacc     3240

aaggtgagcc gctacgtgaa ctggatcaag gagaagacca agctgaccta atgaaagatg     3300

gatttccaag gttaattcat tggaattgaa aattaacagc cccccccccc ccccccctgc     3360

agatctgagc cgaattcctg cagcccgggg gatcagcctc gactgtgcct tctagttgcc     3420

agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca     3480

ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta     3540

ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc     3600

atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggaccgg     3660

tggatctcga tagcaggcat gctggggaga gatcgatctg aggaacccct agtgatggag     3720

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg     3780

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg     3840

gccaaccccc cccccccccc cccccggcga ttctcttgtt tgctccagac tctcaggcaa     3900

tgacctgata gcctttgtag agacctctca aaaatagcta ccctctccgg catgaattta     3960

tcagctagaa cggttgaata tcatattgat ggtgatttga ctgtctccgg cctttctcac     4020

ccgtttgaat ctttacctac acattactca ggcattgcat ttaaaatata tgagggttct     4080

aaaaattttt atccttgcgt tgaaataaag gcttctcccg caaaagtatt acagggtcat     4140

aatgtttttg gtacaaccga tttagcttta tgctctgagg ctttattgct taattttgct     4200

aattctttgc cttgcctgta tgatttattg gatgttggaa tcgcctgatg cggtattttc     4260

tccttacgca tctgtgcggt atttcacacc gcatatggtg cactctcagt acaatctgct     4320

ctgatgccgc atagttatat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt     4380

aagccagccc cgacacccgc caacacagcc agccccgaca cccgccaaca cccgctgacg     4440

cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg     4500

ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc     4560

tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag     4620

gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt     4680

caaatatgta tccgctcatg agacaataac cctgataaat gctcaataat attgaaaaag     4740

gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg     4800

ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt     4860

gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt     4920

tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt     4980

attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa     5040

tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag     5100

agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac     5160

aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac     5220

tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac     5280

cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac     5340

tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact     5400

tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg     5460

tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt     5520

tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat     5580

aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta     5640

gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa     5700

tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga     5760

aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac     5820

aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt     5880

tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc     5940

gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat     6000

cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag     6060

acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc     6120

cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag     6180

cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac     6240

aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg     6300

gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct     6360

atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc     6420

tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga     6480

gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga     6540

agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg     6600


<210>  50
<211>  6661
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE18-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  50
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggctgggcag gagcagctgg cttgagcaga atcttgggac ctgaggctct caggggacct     1140

cccattgggg gatggagggc aatggtggtg gtgcccagga ggtcttctac ttagatgtct     1200

attggatctc taaatgaggc tgcatgcata atcacacaca aacatccact gagaaggtga     1260

cacaccacgt cagcatgggt ccctctgccg gaccacacca ctcctagtga ctatgaggtg     1320

acatccaggc acgttgcact attggctcct gtcggtgagt gcagtgcctg acaacagtga     1380

gctacattta tttgtaaaaa tgaacgccat cagagtagac cacaattgta ctaactctaa     1440

tttgctttgt gttcattttt tcagtttcca gaagtggctt aatgtttcct agggtcaaag     1500

gcagtcaaat gacggtaccc actgggagga tgttgagtaa gatggaaaac tactgatgac     1560

ccttgcagag acagagtatt aggacatgtt tgaacagggg ccgggcgatc agcaggtagc     1620

tctagaggat ccccgtctgt ctgcacattt cgtagagcga gtgttccgat actctaatct     1680

ccctaggcaa ggttcatatt tgtgtaggtt acttattctc cttttgttga ctaagtcaat     1740

aatcagaatc agcaggtttg gagtcagctt ggcagggatc agcagcctgg gttggaagga     1800

gggggtataa aagccccttc accaggagaa gccgtcacac agatccacaa gctcctggct     1860

agaaagaggt aagggtttaa gggatggttg gttggtgggg tattaatgtt taattacctg     1920

gagcacctgc ctgaaatcac tttttttcag gttgggctag cccaccatgc agcgcgtgaa     1980

catgatcatg gccgagagcc ccggcctgat caccatctgc ctgctgggct acctgctgag     2040

cgccgagtgc accgtgttcc tggaccacga gaacgccaac aagatcctga accgccccaa     2100

gcgctacaac agcggcaagc tggaggagtt cgtgcagggc aacctggagc gcgagtgcat     2160

ggaggagaag tgcagcttcg aggaggcccg cgaggtgttc gagaacaccg agcgcaccac     2220

cgagttctgg aagcagtacg tggacggcga ccagtgcgag agcaacccct gcctgaacgg     2280

cggcagctgc aaggacgaca tcaacagcta cgagtgctgg tgccccttcg gcttcgaggg     2340

caagaactgc gagctggacg tgacctgcaa catcaagaac ggccgctgcg agcagttctg     2400

caagaacagc gccgacaaca aggtggtgtg cagctgcacc gagggctacc gcctggccga     2460

gaaccagaag agctgcgagc ccgccgtgcc cttcccctgc ggccgcgtga gcgtgagcca     2520

gaccagcaag ctgacccgcg ccgaggccgt gttccccgac gtggactacg tgaacagcac     2580

cgaggccgag accatcctgg acaacatcac ccagagcacc cagagcttca acgacttcac     2640

ccgcgtggtg ggcggcgagg acgccaagcc cggccagttc ccctggcagg tggtgctgaa     2700

cggcaaggtg gacgccttct gcggcggcag catcgtgaac gagaagtgga tcgtgaccgc     2760

cgcccactgc gtggagaccg gcgtgaagat caccgtggtg gccggcgagc acaacatcga     2820

ggagaccgag cacaccgagc agaagcgcaa cgtgatccgc atcatccccc accacaacta     2880

caacgccgcc atcaacaagt acaaccacga catcgccctg ctggagctgg acgagcccct     2940

ggtgctgaac agctacgtga cccccatctg catcgccgac aaggagtaca ccaacatctt     3000

cctgaagttc ggcagcggct acgtgagcgg ctggggccgc gtgttccaca agggccgcag     3060

cgccctggtg ctgcagtacc tgcgcgtgcc cctggtggac cgcgccacct gcctgctgag     3120

caccaagttc accatctaca acaacatgtt ctgcgccggc ttccacgagg gcggccgcga     3180

cagctgccag ggcgacagcg gcggccccca cgtgaccgag gtggagggca ccagcttcct     3240

gaccggcatc atcagctggg gcgaggagtg cgccatgaag ggcaagtacg gcatctacac     3300

caaggtgagc cgctacgtga actggatcaa ggagaagacc aagctgacct aatgaaagat     3360

ggatttccaa ggttaattca ttggaattga aaattaacag cccccccccc cccccccctg     3420

cagatctgag ccgaattcct gcagcccggg ggatcagcct cgactgtgcc ttctagttgc     3480

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     3540

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     3600

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     3660

catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggaccg     3720

gtggatctcg atagcaggca tgctggggag agatcgatct gaggaacccc tagtgatgga     3780

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg     3840

gcgtcgggcg acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt     3900

ggccaacccc cccccccccc ccccccggcg attctcttgt ttgctccaga ctctcaggca     3960

atgacctgat agcctttgta gagacctctc aaaaatagct accctctccg gcatgaattt     4020

atcagctaga acggttgaat atcatattga tggtgatttg actgtctccg gcctttctca     4080

cccgtttgaa tctttaccta cacattactc aggcattgca tttaaaatat atgagggttc     4140

taaaaatttt tatccttgcg ttgaaataaa ggcttctccc gcaaaagtat tacagggtca     4200

taatgttttt ggtacaaccg atttagcttt atgctctgag gctttattgc ttaattttgc     4260

taattctttg ccttgcctgt atgatttatt ggatgttgga atcgcctgat gcggtatttt     4320

ctccttacgc atctgtgcgg tatttcacac cgcatatggt gcactctcag tacaatctgc     4380

tctgatgccg catagttata tggtgcactc tcagtacaat ctgctctgat gccgcatagt     4440

taagccagcc ccgacacccg ccaacacagc cagccccgac acccgccaac acccgctgac     4500

gcgccctgac gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc     4560

gggagctgca tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc     4620

ctcgtgatac gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca     4680

ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat     4740

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgctcaataa tattgaaaaa     4800

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt     4860

gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt     4920

tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt     4980

ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg     5040

tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga     5100

atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa     5160

gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga     5220

caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa     5280

ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca     5340

ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta     5400

ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac     5460

ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc     5520

gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag     5580

ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga     5640

taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt     5700

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata     5760

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag     5820

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa     5880

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt     5940

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc     6000

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa     6060

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa     6120

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc     6180

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa     6240

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa     6300

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg     6360

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc     6420

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg     6480

ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg     6540

agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg     6600

aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat     6660

g                                                                     6661


<210>  51
<211>  6711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE19-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  51
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

gggaaggggg aagagaccca ctgaaatcct atctcccagc ctcacctctg ctgtctcctc     1140

cacgcttcct gtctccagag ccccgagttc agcataagca gaaagcggcc tgttccctct     1200

ctagggagag gagggttgcg gtctggaggt ctggctcgtc tttatctgcg cattctccca     1260

gcctcctggc ttcagacctc agcgaggcgg cggctgccgg ccggctctcc tcttcctgcc     1320

tgcagacctg gcctgctgct tctttctcct tcctccctcc ctgcctgccc tgcggtttca     1380

aagtagatta gaaataacag tgtcccacat ggaagcctct acttcttcct gggtcaactt     1440

tgatgacgag gctccagaaa acctttgcaa tgctgtgtgg aatttttaaa tcggtgagct     1500

cgtgctcttg ccctatttat ttgtccagcg tacatttctg aacattgtga acgtcgaatg     1560

ggcggtaccc actgggagga tgttgagtaa gatggaaaac tactgatgac ccttgcagag     1620

acagagtatt aggacatgtt tgaacagggg ccgggcgatc agcaggtagc tctagaggat     1680

ccccgtctgt ctgcacattt cgtagagcga gtgttccgat actctaatct ccctaggcaa     1740

ggttcatatt tgtgtaggtt acttattctc cttttgttga ctaagtcaat aatcagaatc     1800

agcaggtttg gagtcagctt ggcagggatc agcagcctgg gttggaagga gggggtataa     1860

aagccccttc accaggagaa gccgtcacac agatccacaa gctcctggct agaaagaggt     1920

aagggtttaa gggatggttg gttggtgggg tattaatgtt taattacctg gagcacctgc     1980

ctgaaatcac tttttttcag gttgggctag cccaccatgc agcgcgtgaa catgatcatg     2040

gccgagagcc ccggcctgat caccatctgc ctgctgggct acctgctgag cgccgagtgc     2100

accgtgttcc tggaccacga gaacgccaac aagatcctga accgccccaa gcgctacaac     2160

agcggcaagc tggaggagtt cgtgcagggc aacctggagc gcgagtgcat ggaggagaag     2220

tgcagcttcg aggaggcccg cgaggtgttc gagaacaccg agcgcaccac cgagttctgg     2280

aagcagtacg tggacggcga ccagtgcgag agcaacccct gcctgaacgg cggcagctgc     2340

aaggacgaca tcaacagcta cgagtgctgg tgccccttcg gcttcgaggg caagaactgc     2400

gagctggacg tgacctgcaa catcaagaac ggccgctgcg agcagttctg caagaacagc     2460

gccgacaaca aggtggtgtg cagctgcacc gagggctacc gcctggccga gaaccagaag     2520

agctgcgagc ccgccgtgcc cttcccctgc ggccgcgtga gcgtgagcca gaccagcaag     2580

ctgacccgcg ccgaggccgt gttccccgac gtggactacg tgaacagcac cgaggccgag     2640

accatcctgg acaacatcac ccagagcacc cagagcttca acgacttcac ccgcgtggtg     2700

ggcggcgagg acgccaagcc cggccagttc ccctggcagg tggtgctgaa cggcaaggtg     2760

gacgccttct gcggcggcag catcgtgaac gagaagtgga tcgtgaccgc cgcccactgc     2820

gtggagaccg gcgtgaagat caccgtggtg gccggcgagc acaacatcga ggagaccgag     2880

cacaccgagc agaagcgcaa cgtgatccgc atcatccccc accacaacta caacgccgcc     2940

atcaacaagt acaaccacga catcgccctg ctggagctgg acgagcccct ggtgctgaac     3000

agctacgtga cccccatctg catcgccgac aaggagtaca ccaacatctt cctgaagttc     3060

ggcagcggct acgtgagcgg ctggggccgc gtgttccaca agggccgcag cgccctggtg     3120

ctgcagtacc tgcgcgtgcc cctggtggac cgcgccacct gcctgctgag caccaagttc     3180

accatctaca acaacatgtt ctgcgccggc ttccacgagg gcggccgcga cagctgccag     3240

ggcgacagcg gcggccccca cgtgaccgag gtggagggca ccagcttcct gaccggcatc     3300

atcagctggg gcgaggagtg cgccatgaag ggcaagtacg gcatctacac caaggtgagc     3360

cgctacgtga actggatcaa ggagaagacc aagctgacct aatgaaagat ggatttccaa     3420

ggttaattca ttggaattga aaattaacag cccccccccc cccccccctg cagatctgag     3480

ccgaattcct gcagcccggg ggatcagcct cgactgtgcc ttctagttgc cagccatctg     3540

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt     3600

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg     3660

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg     3720

atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggaccg gtggatctcg     3780

atagcaggca tgctggggag agatcgatct gaggaacccc tagtgatgga gttggccact     3840

ccctctctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg     3900

acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaacccc     3960

cccccccccc ccccccggcg attctcttgt ttgctccaga ctctcaggca atgacctgat     4020

agcctttgta gagacctctc aaaaatagct accctctccg gcatgaattt atcagctaga     4080

acggttgaat atcatattga tggtgatttg actgtctccg gcctttctca cccgtttgaa     4140

tctttaccta cacattactc aggcattgca tttaaaatat atgagggttc taaaaatttt     4200

tatccttgcg ttgaaataaa ggcttctccc gcaaaagtat tacagggtca taatgttttt     4260

ggtacaaccg atttagcttt atgctctgag gctttattgc ttaattttgc taattctttg     4320

ccttgcctgt atgatttatt ggatgttgga atcgcctgat gcggtatttt ctccttacgc     4380

atctgtgcgg tatttcacac cgcatatggt gcactctcag tacaatctgc tctgatgccg     4440

catagttata tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagcc     4500

ccgacacccg ccaacacagc cagccccgac acccgccaac acccgctgac gcgccctgac     4560

gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca     4620

tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac     4680

gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca ggtggcactt     4740

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt     4800

atccgctcat gagacaataa ccctgataaa tgctcaataa tattgaaaaa ggaagagtat     4860

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt     4920

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg     4980

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga     5040

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg     5100

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt     5160

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     5220

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     5280

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     5340

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     5400

tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     5460

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     5520

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     5580

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     5640

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     5700

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     5760

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     5820

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     5880

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     5940

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     6000

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     6060

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     6120

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     6180

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     6240

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     6300

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     6360

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     6420

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     6480

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     6540

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     6600

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     6660

gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat g              6711


<210>  52
<211>  6575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE20-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  52
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggggaaaaca gggagacagt ttcctgtttg agatgttggg agatgcttcg agtagtatat     1140

ttactggaaa tagacattca acttggatgt ccctttttgg aaatgtgcct gcgtccaggg     1200

ctgggttggg gccccaatga actttggctc tgacacagct gttgccacac tcagtggaac     1260

tgaatctatg tttgtcttcc ccggcatcct tcaccccaac tctccccgcc acaacataca     1320

tcccatgcca gcctggggac cctcaaaggt ggcttcatca ttaggtttgt ggctgggtcc     1380

cactgaagta agtcttggca ctcagaggga taggaattga atgaagaggt acccactggg     1440

aggatgttga gtaagatgga aaactactga tgacccttgc agagacagag tattaggaca     1500

tgtttgaaca ggggccgggc gatcagcagg tagctctaga ggatccccgt ctgtctgcac     1560

atttcgtaga gcgagtgttc cgatactcta atctccctag gcaaggttca tatttgtgta     1620

ggttacttat tctccttttg ttgactaagt caataatcag aatcagcagg tttggagtca     1680

gcttggcagg gatcagcagc ctgggttgga aggagggggt ataaaagccc cttcaccagg     1740

agaagccgtc acacagatcc acaagctcct ggctagaaag aggtaagggt ttaagggatg     1800

gttggttggt ggggtattaa tgtttaatta cctggagcac ctgcctgaaa tcactttttt     1860

tcaggttggg ctagcccacc atgcagcgcg tgaacatgat catggccgag agccccggcc     1920

tgatcaccat ctgcctgctg ggctacctgc tgagcgccga gtgcaccgtg ttcctggacc     1980

acgagaacgc caacaagatc ctgaaccgcc ccaagcgcta caacagcggc aagctggagg     2040

agttcgtgca gggcaacctg gagcgcgagt gcatggagga gaagtgcagc ttcgaggagg     2100

cccgcgaggt gttcgagaac accgagcgca ccaccgagtt ctggaagcag tacgtggacg     2160

gcgaccagtg cgagagcaac ccctgcctga acggcggcag ctgcaaggac gacatcaaca     2220

gctacgagtg ctggtgcccc ttcggcttcg agggcaagaa ctgcgagctg gacgtgacct     2280

gcaacatcaa gaacggccgc tgcgagcagt tctgcaagaa cagcgccgac aacaaggtgg     2340

tgtgcagctg caccgagggc taccgcctgg ccgagaacca gaagagctgc gagcccgccg     2400

tgcccttccc ctgcggccgc gtgagcgtga gccagaccag caagctgacc cgcgccgagg     2460

ccgtgttccc cgacgtggac tacgtgaaca gcaccgaggc cgagaccatc ctggacaaca     2520

tcacccagag cacccagagc ttcaacgact tcacccgcgt ggtgggcggc gaggacgcca     2580

agcccggcca gttcccctgg caggtggtgc tgaacggcaa ggtggacgcc ttctgcggcg     2640

gcagcatcgt gaacgagaag tggatcgtga ccgccgccca ctgcgtggag accggcgtga     2700

agatcaccgt ggtggccggc gagcacaaca tcgaggagac cgagcacacc gagcagaagc     2760

gcaacgtgat ccgcatcatc ccccaccaca actacaacgc cgccatcaac aagtacaacc     2820

acgacatcgc cctgctggag ctggacgagc ccctggtgct gaacagctac gtgaccccca     2880

tctgcatcgc cgacaaggag tacaccaaca tcttcctgaa gttcggcagc ggctacgtga     2940

gcggctgggg ccgcgtgttc cacaagggcc gcagcgccct ggtgctgcag tacctgcgcg     3000

tgcccctggt ggaccgcgcc acctgcctgc tgagcaccaa gttcaccatc tacaacaaca     3060

tgttctgcgc cggcttccac gagggcggcc gcgacagctg ccagggcgac agcggcggcc     3120

cccacgtgac cgaggtggag ggcaccagct tcctgaccgg catcatcagc tggggcgagg     3180

agtgcgccat gaagggcaag tacggcatct acaccaaggt gagccgctac gtgaactgga     3240

tcaaggagaa gaccaagctg acctaatgaa agatggattt ccaaggttaa ttcattggaa     3300

ttgaaaatta acagcccccc cccccccccc cctgcagatc tgagccgaat tcctgcagcc     3360

cgggggatca gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc     3420

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga     3480

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga     3540

cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat     3600

ggcttctgag gcggaaagaa ccagctgggg accggtggat ctcgatagca ggcatgctgg     3660

ggagagatcg atctgaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc     3720

gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt ggtcgcccgg     3780

cctcagtgag cgagcgagcg cgcagagagg gagtggccaa cccccccccc cccccccccc     3840

ggcgattctc ttgtttgctc cagactctca ggcaatgacc tgatagcctt tgtagagacc     3900

tctcaaaaat agctaccctc tccggcatga atttatcagc tagaacggtt gaatatcata     3960

ttgatggtga tttgactgtc tccggccttt ctcacccgtt tgaatcttta cctacacatt     4020

actcaggcat tgcatttaaa atatatgagg gttctaaaaa tttttatcct tgcgttgaaa     4080

taaaggcttc tcccgcaaaa gtattacagg gtcataatgt ttttggtaca accgatttag     4140

ctttatgctc tgaggcttta ttgcttaatt ttgctaattc tttgccttgc ctgtatgatt     4200

tattggatgt tggaatcgcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc     4260

acaccgcata tggtgcactc tcagtacaat ctgctctgat gccgcatagt tatatggtgc     4320

actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca     4380

cagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc     4440

ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc     4500

accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt     4560

taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg     4620

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca     4680

ataaccctga taaatgctca ataatattga aaaaggaaga gtatgagtat tcaacatttc     4740

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     4800

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     4860

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     4920

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa     4980

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     5040

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     5100

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     5160

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     5220

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca     5280

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     5340

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     5400

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     5460

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     5520

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     5580

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     5640

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     5700

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     5760

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     5820

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     5880

gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac     5940

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     6000

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     6060

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     6120

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     6180

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     6240

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     6300

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     6360

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     6420

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     6480

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     6540

ccgcctctcc ccgcgcgttg gccgattcat taatg                                6575


<210>  53
<211>  6616
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVsc-HS-CRE21-TTRenh-TTRm-MVM-hFIXcoPadua-bghpolyA

<400>  53
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg       60

aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag      120

caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag      180

tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga      240

ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg      300

cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa      360

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc      420

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt      480

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag      540

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt      600

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt      660

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt      720

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt      780

aacaaaaatt taacgcgaac tttaacaaaa tattaacgtt tacaatttaa atatttgctt      840

atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca      900

tgctagtttt acgattaccg ttcatcgccc tgcgcgctcg ctcgctcact gaggccgccc      960

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     1020

gcagagaggg agtggaattc acgcgtggat ctgaattctg tacaggcgtg gtacggccgc     1080

ggggaggttg cagtaagcca agattgtgcc actgcactcc aacctgggtg acagagccag     1140

actctgtctc aagaaaataa agagaaaaag aactagattc aggctgtatg tgggcaccat     1200

ctacagacat cagacacaca catttaggag taataatgat gcaatattgc caaatgtttc     1260

tcagcaacca tgtgcaactg ttgcatgtac tgtttatttc taactcagga ggatctctct     1320

aaccacacat tgcaagaaaa tagactttca gtgtttctgg caaaacaaag agtttttttg     1380

ttggcattta tgctgaaagg gaagagttaa aatgttaatt tgtctttttt cttacctcca     1440

agttcactca aatcctctct tgaagcaggg tacccactgg gaggatgttg agtaagatgg     1500

aaaactactg atgacccttg cagagacaga gtattaggac atgtttgaac aggggccggg     1560

cgatcagcag gtagctctag aggatccccg tctgtctgca catttcgtag agcgagtgtt     1620

ccgatactct aatctcccta ggcaaggttc atatttgtgt aggttactta ttctcctttt     1680

gttgactaag tcaataatca gaatcagcag gtttggagtc agcttggcag ggatcagcag     1740

cctgggttgg aaggaggggg tataaaagcc ccttcaccag gagaagccgt cacacagatc     1800

cacaagctcc tggctagaaa gaggtaaggg tttaagggat ggttggttgg tggggtatta     1860

atgtttaatt acctggagca cctgcctgaa atcacttttt ttcaggttgg gctagcccac     1920

catgcagcgc gtgaacatga tcatggccga gagccccggc ctgatcacca tctgcctgct     1980

gggctacctg ctgagcgccg agtgcaccgt gttcctggac cacgagaacg ccaacaagat     2040

cctgaaccgc cccaagcgct acaacagcgg caagctggag gagttcgtgc agggcaacct     2100

ggagcgcgag tgcatggagg agaagtgcag cttcgaggag gcccgcgagg tgttcgagaa     2160

caccgagcgc accaccgagt tctggaagca gtacgtggac ggcgaccagt gcgagagcaa     2220

cccctgcctg aacggcggca gctgcaagga cgacatcaac agctacgagt gctggtgccc     2280

cttcggcttc gagggcaaga actgcgagct ggacgtgacc tgcaacatca agaacggccg     2340

ctgcgagcag ttctgcaaga acagcgccga caacaaggtg gtgtgcagct gcaccgaggg     2400

ctaccgcctg gccgagaacc agaagagctg cgagcccgcc gtgcccttcc cctgcggccg     2460

cgtgagcgtg agccagacca gcaagctgac ccgcgccgag gccgtgttcc ccgacgtgga     2520

ctacgtgaac agcaccgagg ccgagaccat cctggacaac atcacccaga gcacccagag     2580

cttcaacgac ttcacccgcg tggtgggcgg cgaggacgcc aagcccggcc agttcccctg     2640

gcaggtggtg ctgaacggca aggtggacgc cttctgcggc ggcagcatcg tgaacgagaa     2700

gtggatcgtg accgccgccc actgcgtgga gaccggcgtg aagatcaccg tggtggccgg     2760

cgagcacaac atcgaggaga ccgagcacac cgagcagaag cgcaacgtga tccgcatcat     2820

cccccaccac aactacaacg ccgccatcaa caagtacaac cacgacatcg ccctgctgga     2880

gctggacgag cccctggtgc tgaacagcta cgtgaccccc atctgcatcg ccgacaagga     2940

gtacaccaac atcttcctga agttcggcag cggctacgtg agcggctggg gccgcgtgtt     3000

ccacaagggc cgcagcgccc tggtgctgca gtacctgcgc gtgcccctgg tggaccgcgc     3060

cacctgcctg ctgagcacca agttcaccat ctacaacaac atgttctgcg ccggcttcca     3120

cgagggcggc cgcgacagct gccagggcga cagcggcggc ccccacgtga ccgaggtgga     3180

gggcaccagc ttcctgaccg gcatcatcag ctggggcgag gagtgcgcca tgaagggcaa     3240

gtacggcatc tacaccaagg tgagccgcta cgtgaactgg atcaaggaga agaccaagct     3300

gacctaatga aagatggatt tccaaggtta attcattgga attgaaaatt aacagccccc     3360

cccccccccc ccctgcagat ctgagccgaa ttcctgcagc ccgggggatc agcctcgact     3420

gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg     3480

gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg     3540

agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg     3600

gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggcggaaaga     3660

accagctggg gaccggtgga tctcgatagc aggcatgctg gggagagatc gatctgagga     3720

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgc     3780

ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc     3840

gcgcagagag ggagtggcca accccccccc cccccccccc cggcgattct cttgtttgct     3900

ccagactctc aggcaatgac ctgatagcct ttgtagagac ctctcaaaaa tagctaccct     3960

ctccggcatg aatttatcag ctagaacggt tgaatatcat attgatggtg atttgactgt     4020

ctccggcctt tctcacccgt ttgaatcttt acctacacat tactcaggca ttgcatttaa     4080

aatatatgag ggttctaaaa atttttatcc ttgcgttgaa ataaaggctt ctcccgcaaa     4140

agtattacag ggtcataatg tttttggtac aaccgattta gctttatgct ctgaggcttt     4200

attgcttaat tttgctaatt ctttgccttg cctgtatgat ttattggatg ttggaatcgc     4260

ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat atggtgcact     4320

ctcagtacaa tctgctctga tgccgcatag ttatatggtg cactctcagt acaatctgct     4380

ctgatgccgc atagttaagc cagccccgac acccgccaac acagccagcc ccgacacccg     4440

ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa     4500

gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc     4560

gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg     4620

gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta     4680

tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctc     4740

aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct     4800

tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag     4860

atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta     4920

agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc     4980

tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca     5040

tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg     5100

atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg     5160

ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca     5220

tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa     5280

acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa     5340

ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg gaggcggata     5400

aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat     5460

ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc     5520

cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata     5580

gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt     5640

actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga     5700

agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag     5760

cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa     5820

tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag     5880

agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg     5940

tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat     6000

acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta     6060

ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg     6120

gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc     6180

gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa     6240

gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc     6300

tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt     6360

caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct     6420

tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc     6480

gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg     6540

agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt     6600

ggccgattca ttaatg                                                     6616


<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  54

Ser Phe Ser Gln Asn Pro Pro Val Leu Thr Arg His Gln Arg 
1               5                   10                  


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  55
cacgagaacg ccaacaagat                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  56
cacttctcct ccatgcactc                                                   20


<210>  57
<211>  771
<212>  DNA
<213>  Homo sapiens

<400>  57
caggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt       60

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      120

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      180

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      240

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      300

tggtttaggt agtgtgagag ggtccgggtt caaaaccact tgctgggtgg ggagtcgtca      360

gtaagtggct atgccccgac cccgaagcct gtttccccat ctgtacaatg gaaatgataa      420

agacgcccat ctgatagggt ttttgtggca aataaacatt tggttttttt gttttgtttt      480

gttttgtttt ttgagatgga ggtttgctct gtcgcccagg ctggagtgca gtgacacaat      540

ctcatctcac cacaaccttc ccctgcctca gcctcccaag tagctgggat tacaagcatg      600

tgccaccaca cctggctaat tttctatttt tagtagagac gggtttctcc atgttggtca      660

gcctcagcct cccaagtaac tgggattaca ggcctgtgcc accacacccg gctaattttt      720

tctatttttg acagggacgg ggtttcacca tgttggtcag gctcctctag a               771


<210>  58
<211>  328
<212>  DNA
<213>  Homo sapiens

<400>  58
caggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt       60

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      120

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      180

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      240

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      300

tggtttaggt agtgtgagag ggtccggg                                         328


