                         SEQUENCE LISTING

<110>  UNIVERSITY OF LIMERICK
 
<120>  Treatment of immune dysregulation disorders.

<130>  P12545EPC00

<150>  18202147.7
<151>  2018-10-23

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  1530
<212>  PRT
<213>  Lactobacillus salivarius

<400>  1

Met Glu Lys Leu Leu Gly Glu Lys Arg Arg Tyr Lys Leu Tyr Lys Ala 
1               5                   10                  15      


Lys Ser Lys Trp Val Val Ser Ala Ile Ile Thr Ile Ser Gly Val Thr 
            20                  25                  30          


Phe Leu Val Thr Ser Pro Val Ser Asn Ala Gln Ala Asp Thr Val Asn 
        35                  40                  45              


Gly Ser Glu Ser Val Lys Thr Glu Ala Thr Gln Ala Ser Gly Ser Ser 
    50                  55                  60                  


Val Gln Asp Asn Ala Thr Ala Lys Thr Thr Val Thr Thr Asn Ser Asn 
65                  70                  75                  80  


Ser Ser Asn Asn Val Ser Asn Val Gln Thr Asp Thr Val Lys Glu Ala 
                85                  90                  95      


Ala Thr Ser Asn Val Asp Ser Val Ala Ser Gln Asn Gln Ala Thr Thr 
            100                 105                 110         


Ala Gln Gln Ala Lys Thr Thr Ala Asp Thr Ala Asp Gln Thr Val Pro 
        115                 120                 125             


Pro Thr Thr Tyr Lys Asp His Val Lys Gly Asn Val Gln Thr Ala Trp 
    130                 135                 140                 


Asp Asn Gly Tyr Lys Gly Gln Gly Met Val Val Ala Val Ile Asp Ser 
145                 150                 155                 160 


Gly Ala Asp Thr Asn His Lys Asp Phe Ser Lys Ala Pro Glu Ser Pro 
                165                 170                 175     


Ala Ile Ser Lys Glu Asp Ala Asp Lys Lys Ile Ser Glu Leu Gly Tyr 
            180                 185                 190         


Gly Lys Tyr Ala Ser Glu Lys Phe Pro Phe Val Tyr Asn Tyr Ala Ser 
        195                 200                 205             


Arg Asp Asn Asn Trp Val Lys Asp Asp Gly Pro Asp Ala Ser Glu His 
    210                 215                 220                 


Gly Gln His Val Ala Gly Ile Ile Gly Ala Asp Gly Gln Pro Asn Gly 
225                 230                 235                 240 


Asn Glu Arg Tyr Ala Val Gly Val Ala Pro Glu Thr Gln Leu Met Met 
                245                 250                 255     


Met Arg Val Phe Asn Asp Gln Phe Ala Asp Glu Asn Thr Asp Asp Ile 
            260                 265                 270         


Ala Gln Ala Ile Tyr Asp Ala Val Lys Leu Gly Ala Asn Val Ile Gln 
        275                 280                 285             


Met Ser Leu Gly Gln Gly Val Ala Ala Ala Asn Leu Asn Asp Val Glu 
    290                 295                 300                 


Gln Lys Ala Val Glu Tyr Ala Thr Gln His Gly Val Phe Val Ser Ile 
305                 310                 315                 320 


Ser Ala Ser Asn Asn Gly Asn Ser Ala Ser Val Thr Gly Glu Glu Val 
                325                 330                 335     


Pro Tyr Lys Pro Gly Gly Ala Asp Gly Asn Phe Glu Pro Phe Ser Ser 
            340                 345                 350         


Ser Thr Val Ala Asn Pro Gly Ala Ser Arg Asn Ala Met Thr Val Ala 
        355                 360                 365             


Ala Glu Asn Ser Val Val Gly Ala Gly Asp Asp Met Ala Asp Phe Ser 
    370                 375                 380                 


Ser Trp Gly Pro Leu Gln Asp Phe Thr Leu Lys Pro Asp Val Ser Ala 
385                 390                 395                 400 


Pro Gly Val Ser Val Thr Ser Thr Gly Asn Asp Asn Arg Tyr Asn Thr 
                405                 410                 415     


Met Ser Gly Thr Ser Met Ala Gly Pro Phe Asn Ala Gly Val Ala Ala 
            420                 425                 430         


Leu Val Met Gln Arg Leu Lys Ala Thr Thr Asn Leu Asn Gly Ala Asp 
        435                 440                 445             


Leu Val Gln Ala Thr Lys Ala Leu Ile Met Asn Thr Ala Lys Pro Met 
    450                 455                 460                 


Thr Gln Gln Gly Tyr Asp Thr Pro Val Ser Pro Arg Arg Gln Gly Ala 
465                 470                 475                 480 


Gly Glu Ile Asp Ala Gly Ala Ala Thr Glu Ser Pro Val Tyr Val Val 
                485                 490                 495     


Ala Ala Asp Gly Thr Ser Ser Val Ser Leu Arg Lys Val Gly Asp Ser 
            500                 505                 510         


Thr Gln Phe Ala Leu Thr Phe Lys Asn Leu Ser Asp Lys Asp Gln Thr 
        515                 520                 525             


Tyr Thr Phe Asp Asp Phe Gly Gly Gly Leu Thr Glu Val Arg Asp Ala 
    530                 535                 540                 


Asp Thr Gly Thr Phe His Asp Val Tyr Leu Ala Gly Ala His Val Tyr 
545                 550                 555                 560 


Gly Asn Lys Thr Val Thr Val Lys Ala Gly Gln Ser Ala Thr Tyr Asn 
                565                 570                 575     


Phe Thr Leu Ser Leu Thr Gly Leu Lys Glu Asn Gln Leu Val Glu Gly 
            580                 585                 590         


Trp Leu Arg Phe Val Gly Asn Asp Gly Gln Asn Gln Leu Val Val Pro 
        595                 600                 605             


Tyr Leu Ala Tyr Tyr Gly Asp Met Thr Ser Glu Asp Val Phe Asp Lys 
    610                 615                 620                 


Ala Ala Asn Gln Glu Gly Thr Val Tyr Gly Gly Asn Tyr Phe Val Asn 
625                 630                 635                 640 


Glu Asp Asn Tyr Pro Arg Gly Val Ala Asp Glu Asp Ser Leu Lys Ala 
                645                 650                 655     


Leu Val Asn Leu Glu Gly Asn Tyr Asn Trp Gln Gln Val Ala Lys Leu 
            660                 665                 670         


Tyr Gln Asp Gly Lys Val Ala Phe Ser Pro Asn Ala Asp Gly Lys Ser 
        675                 680                 685             


Asp Leu Leu Lys Pro Tyr Ala Phe Val Lys Gln Asn Leu Lys Asp Leu 
    690                 695                 700                 


Lys Val Glu Val Leu Asp Lys Ser Gly Lys Val Val Arg Val Val Ala 
705                 710                 715                 720 


Asp Glu Gln Gly Leu Asp Lys Ser Tyr Tyr Glu Ser Gly Val Asn Lys 
                725                 730                 735     


Asp Val Thr Leu Ser Val Ser Met Arg Asn Asn Pro Asn Thr Leu Ala 
            740                 745                 750         


Trp Asp Gly Lys Val Tyr Asp Asp Lys Ala Gly Glu Met Val Asn Ala 
        755                 760                 765             


Ala Asp Gly Glu Tyr Thr Tyr Arg Tyr Val Ala Thr Leu Tyr Asn Asp 
    770                 775                 780                 


Gly Val Asn Lys Val Gln Thr Ala Asp Tyr Pro Val Val Ile Asp Thr 
785                 790                 795                 800 


Thr Ala Pro Val Leu Ser Asn Val Lys Tyr Asp Ala Ala Thr His Thr 
                805                 810                 815     


Leu Ser Phe Asp Tyr Lys Asp Thr Gly Ser Gly Phe Thr Asp Tyr Ser 
            820                 825                 830         


Tyr Ala Val Val Lys Val Asn Asp Lys Thr Phe Gly Tyr Lys Leu Asn 
        835                 840                 845             


Asp Gly Lys Asn Ser Lys Phe Leu Asp Ala Ala Lys Thr Ser Gly Thr 
    850                 855                 860                 


Phe Lys Ala Val Leu Gly Ser Asp Thr Leu Ala Ala Leu Thr Ala Ala 
865                 870                 875                 880 


Lys Asn Ala Leu Ser Val Ala Val Ser Asp Val Ala Asp Asn Thr Ser 
                885                 890                 895     


Thr Val Thr Leu Leu Val Asn Gly Asn Asn Asp Ala Thr Thr Lys Val 
            900                 905                 910         


Ser Val Trp Asn Ala Thr Asn Gly Leu Glu Leu Asp Gln Ser Ser Pro 
        915                 920                 925             


Asp Tyr Gln Ala Ala Thr Ser Thr Tyr Asn Leu Arg Gly Asn Ala Thr 
    930                 935                 940                 


Ser Asp Phe Tyr Tyr Asn Gly Ala Leu Val Gln Val Asp Asn Ser Gly 
945                 950                 955                 960 


Asn Phe Val Val Pro Val Ser Thr Ser Asp Thr Ala Val Val Phe Thr 
                965                 970                 975     


Ser Asp Ala Ala Gly Lys Asn Val Val Tyr Lys Leu Asn Thr Ala Thr 
            980                 985                 990         


Pro Lys Ala Val Phe Ala Trp Gln  Val Asn Asn Thr Val  Lys Glu Asn 
        995                 1000                 1005             


Phe Gly  Ile Val Leu Asp Thr  Val Val Ser Asn Asn  Lys Asp Asp 
    1010                 1015                 1020             


Val Val  Val Gln Ala Ala Val  Thr Lys Gly Asp Asn  Val Glu Ala 
    1025                 1030                 1035             


Tyr Ala  Arg Asp Tyr Phe Thr  Gly Ala Val Tyr Lys  Ala Asp Val 
    1040                 1045                 1050             


Lys Asp  Gly Leu Ala Thr Phe  His Val Lys Val Thr  Asn Asn Ser 
    1055                 1060                 1065             


Gly Arg  Thr Val Leu Leu Gly  Trp Thr Glu Val Val  Gly Pro Thr 
    1070                 1075                 1080             


Phe Asn  Asp Val Gln Arg Thr  Ser Ala Asn Gly Val  Tyr Leu Gly 
    1085                 1090                 1095             


Val Asp  Thr Asp Thr Glu Asn  Pro Thr Pro Ala Pro  Ala Phe Thr 
    1100                 1105                 1110             


Ser Ala  Asp Gln Leu Gly Thr  Asn Val Val Gln Glu  Lys Ala Asp 
    1115                 1120                 1125             


Ser Ala  Thr Ile Gly Asn Pro  Gly Asp Leu Pro Gly  His Ser Leu 
    1130                 1135                 1140             


Lys Asp  Leu Thr Thr Arg Ala  Asp Ala Asn Pro Asp  Ile His Phe 
    1145                 1150                 1155             


Asp Tyr  Leu Lys Asp Asn Asp  Tyr Asn Trp Val Gly  Ala Gln Ala 
    1160                 1165                 1170             


Val Lys  Asp Gly Val Tyr Asn  Pro Ser Thr Gln Val  Phe Thr Leu 
    1175                 1180                 1185             


Thr Gly  Lys Val Asp Pro Asn  Val Lys Ser Leu Val  Val Leu Gly 
    1190                 1195                 1200             


Asp Ser  Tyr Asn Glu Asp Asp  Pro Val Asn Lys Val  Asn Leu Asn 
    1205                 1210                 1215             


Ser Asp  Gly Thr Phe Ser Phe  Gln Phe His Thr Ala  Pro Thr Ser 
    1220                 1225                 1230             


Gln Arg  Pro Val Ala Tyr Ile  Tyr Thr Lys Asp Asp  Gly Ser Thr 
    1235                 1240                 1245             


Thr Arg  Gly Thr Met Glu Leu  Ile Leu Asp Thr Val  Leu Pro Thr 
    1250                 1255                 1260             


Leu Ser  Leu Asn Asn Val Ala  Asn Leu Gln Leu Asp  Ser Asn Gly 
    1265                 1270                 1275             


Asp Tyr  Gln Val Tyr Thr Asn  Asn Lys Asp Phe Ser  Val Ser Gly 
    1280                 1285                 1290             


Glu Ala  Thr Asp Asn Leu Asp  Gly Tyr Arg Phe Phe  Phe Asn Gly 
    1295                 1300                 1305             


Asp Asn  Asp Tyr Arg Glu Phe  His Asn Ser Gly Val  Asn Phe Val 
    1310                 1315                 1320             


Ala Glu  Ala His Gln Asp Gly  Ser Thr Val Thr Asn  Pro Tyr Pro 
    1325                 1330                 1335             


Ala Tyr  Lys Phe Ser Lys Thr  Phe Asn Leu Ala Asp  Ala Thr Gly 
    1340                 1345                 1350             


Glu Thr  Thr His Val Tyr Thr  Leu Ser Val Val Asp  Leu Thr Gly 
    1355                 1360                 1365             


Asn Thr  Val Thr Arg Lys Phe  Tyr Val His Tyr Gln  Pro Ala Ser 
    1370                 1375                 1380             


Asp Thr  Val Lys Thr Val Thr  Thr Asp Lys Asp Gly  Ala Thr Lys 
    1385                 1390                 1395             


Val Leu  Val Asp Tyr Asn Asn  Asn Thr Leu Gln Val  Lys Asp Asn 
    1400                 1405                 1410             


Thr Gly  Asn Trp Val Asn Ala  Thr Ala Gly Val Glu  Ala Ala Lys 
    1415                 1420                 1425             


Asn Tyr  Arg Val Val Asn Glu  Tyr Gly Asn Val Val  Leu Leu Leu 
    1430                 1435                 1440             


Asn Val  Leu Ala Asp Lys Glu  Gln Asp Asn Asn Lys  Val Gln Val 
    1445                 1450                 1455             


Asn Glu  Val Thr Asn Asn Lys  Val Glu Gln Thr Val  Val Thr Lys 
    1460                 1465                 1470             


Thr Val  Ser Asn Lys Ser Val  Ala Lys Val Gly Lys  Lys Ala Ala 
    1475                 1480                 1485             


Glu Pro  Val Lys Val Leu Pro  Gln Thr Gly Glu Asn  Asn Ser Lys 
    1490                 1495                 1500             


Ser Thr  Ser Val Leu Gly Ala  Val Leu Ala Ser Ile  Ala Gly Phe 
    1505                 1510                 1515             


Leu Gly  Ala Leu Gly Leu Arg  Arg Val Lys Lys Asp  
    1520                 1525                 1530 


<210>  2
<211>  4590
<212>  DNA
<213>  Lactobacillus salivarius

<400>  2
atggaaaagt tgctaggtga aaaacgccgc tacaagcttt ataaagctaa atctaagtgg       60

gtggtgtcag cgattattac tatttctgga gttacatttt tagtgacaag tccagtttct      120

aacgctcaag ccgataccgt taatggtagt gaaagtgtaa aaacagaagc tactcaggca      180

tcaggttcga gtgtgcagga taatgcgaca gctaaaacaa ctgttacaac caatagtaat      240

agttctaaca atgtttctaa tgttcaaact gataccgtaa aagaagcagc aacgagcaat      300

gttgattcag tagctagtca aaatcaagct acaacagctc aacaggctaa aactactgct      360

gatactgctg atcagacagt accaccaaca acctataaag atcatgtcaa aggaaatgtt      420

caaactgcat gggataatgg ctataaagga caaggtatgg tggttgctgt tattgattct      480

ggtgctgata caaaccataa agatttctct aaagctcctg aatctccagc aatttctaag      540

gaagatgctg acaagaagat tagcgagcta ggctacggga aatatgcttc agagaaattc      600

ccattcgtat ataattatgc gagtcgtgac aacaactggg ttaaagatga tggcccagat      660

gcatcagaac acggtcaaca cgttgctggt atcattggtg ctgacggcca accaaatggc      720

aatgaacgct atgcagtagg ggtagcacct gaaacacagt taatgatgat gcgagtattt      780

aatgatcaat ttgctgatga aaatactgat gatattgctc aagcaattta tgacgcagtt      840

aaattaggtg ctaatgtaat tcaaatgtcc ttaggtcaag gcgtcgcagc tgctaatttg      900

aatgatgtag agcagaaagc ggttgaatat gcaactcaac atggtgtgtt cgtctccatt      960

tcagcttcta acaatggtaa ttcggcaagt gttactggtg aagaagttcc ttataaacca     1020

ggtggagcag atggaaactt tgaaccattc tctagtagta cggtagctaa tccaggtgca     1080

tcgcgcaatg caatgacagt tgcagctgaa aactcggttg taggtgctgg tgatgacatg     1140

gcagacttct cttcttgggg tcctttacaa gatttcactt tgaaaccaga tgtatcagct     1200

cctggggtta gtgtaacttc aacagggaac gataatcgtt acaatactat gagtggaact     1260

tctatggctg gtccatttaa cgctggggtt gcagctttag taatgcaaag attaaaagct     1320

actactaact taaatggagc agatttagtt caagctacta aagctttaat catgaataca     1380

gctaaaccaa tgacgcaaca aggatatgac actccagttt ctcctagacg tcaaggtgct     1440

ggtgaaattg atgcaggtgc tgcaacagaa tctccagtat atgttgtggc agcagacggc     1500

acaagttctg tatctttgag aaaagttgga gattcaactc aattcgcact aacgtttaag     1560

aacttatccg ataaagatca aacatatact tttgatgatt ttggtggtgg attaactgaa     1620

gtgcgcgatg ccgatacagg aactttccac gatgtttatc tggcaggagc acatgtctat     1680

ggaaataaga cagtaaccgt taaagctgga caaagcgcaa cttataattt cacattatct     1740

ttaacaggtt tgaaagaaaa tcaattagtt gaaggttggt tgagatttgt aggaaatgat     1800

ggtcaaaatc aattagtagt tccatatctc gcatattatg gtgatatgac aagtgaagat     1860

gtatttgaca aagctgctaa tcaagaaggc acagtctatg gtggtaacta ctttgttaat     1920

gaagataact atccaagagg ggtagctgat gaagattcct taaaggcttt agtaaatctt     1980

gaaggtaatt ataattggca acaagttgct aaattatacc aagatggaaa agttgcattc     2040

tcaccaaatg ctgacggtaa gagtgactta ttaaaaccat atgcctttgt taaacaaaat     2100

ctaaaggatc ttaaagttga agtattagat aagagtggaa aagttgttcg tgtagttgca     2160

gatgaacaag gtctggataa gtcttactat gaaagtggag ttaataaaga cgtaacttta     2220

tcagtttcaa tgcgtaataa tccaaatact ttggcttggg atggaaaagt atacgatgat     2280

aaggccggtg aaatggtaaa tgcagcagat ggtgaatata catatcgtta tgttgctact     2340

ttgtataatg atggtgtaaa taaggttcaa acagctgatt atccagtagt tatcgacaca     2400

acagctccag tattatcaaa tgttaagtat gatgctgcaa cacatacttt aagctttgat     2460

tataaagata caggatctgg ctttacagat tattcttatg cagtagttaa agttaatgat     2520

aagacatttg gctataagtt aaatgatggc aagaattcga agttcttaga tgcagctaaa     2580

acatcaggaa catttaaagc cgtattaggt agtgatactt tagcagcact tactgcagct     2640

aagaatgctt tatcagttgc agttagcgat gtagctgata atacttcaac agtaacctta     2700

ctggtaaatg gaaataatga tgcaacaact aaagtatctg tttggaatgc aactaatgga     2760

ttagaactcg atcaaagttc cccagattat caagcagcaa cttcaactta taacttacgt     2820

gggaatgcaa catctgattt ctattacaat ggtgcattag ttcaagttga taacagtggt     2880

aattttgtgg ttcctgtaag tacaagtgat actgcggttg tcttcacatc agatgcagct     2940

ggtaagaatg tagtatataa attgaataca gcaactccaa aggctgtttt tgcatggcaa     3000

gtaaataata ctgttaagga aaactttggt attgttttag atacagtcgt aagcaacaac     3060

aaggatgatg tagtcgtaca agcagcggtt actaaggggg ataatgttga agcttatgca     3120

cgcgactact tcacaggtgc agtatataaa gcagatgtaa aagatggatt agcaactttc     3180

cacgtaaaag taactaataa tagtggtaga actgtattat taggatggac agaagttgta     3240

ggaccaacat ttaatgatgt tcaaagaact tctgcaaatg gtgtttattt gggtgttgat     3300

acagatacag agaatcctac gccagcacca gcctttacaa gtgctgacca attaggaaca     3360

aatgttgttc aagaaaaagc tgattctgct acaattggta atccaggaga tttgccagga     3420

cacagtctaa aggacctaac aacacgtgca gatgctaacc cagatatcca ctttgactac     3480

ttgaaagata atgattacaa ctgggtagga gcgcaagctg ttaaagatgg tgtatataat     3540

ccatcaacac aagtatttac tttaacaggt aaggttgatc caaatgttaa atcattggtg     3600

gtattgggag atagttacaa tgaagatgat cctgtaaata aggttaactt aaatagtgat     3660

ggaacattta gtttccaatt ccatacagca ccaacttcac aaagacctgt tgcttacatc     3720

tatacaaaag atgatggttc aacaactaga ggtacaatgg agttaatctt agatacagtt     3780

cttccaacac ttagcttaaa taatgtggct aatttacaac tggatagtaa tggtgattac     3840

caagtctaca ctaataataa agactttagt gtatctggag aagctactga taatttggac     3900

ggatatcgtt tcttcttcaa tggagataat gattatcgtg aattccacaa ttctggtgtg     3960

aactttgttg ctgaagctca tcaagatgga agtacagtga ctaatccata tccagcatac     4020

aagtttagta agacatttaa cttagctgat gcaactggcg aaacaacaca tgtatataca     4080

ttgagtgtag ttgacttgac aggtaatact gtaactagga agttctatgt tcactatcaa     4140

ccagctagtg atacagttaa gactgtaaca actgataaag atggtgcaac caaagttcta     4200

gtagattaca ataacaatac actacaagta aaagataata ctggtaactg ggtaaatgct     4260

actgctggag ttgaagctgc taagaattat cgagtagtta atgaatatgg taatgtggta     4320

ttgttactaa atgttcttgc agataaagaa caagacaata ataaagtaca agttaatgaa     4380

gttacaaata ataaagtaga acaaacagta gtaactaaga ctgtttcaaa taaatctgta     4440

gctaaagtgg gcaaaaaagc tgcagaacca gtaaaagtat taccacaaac tggtgaaaat     4500

aacagtaaat ctacttctgt tctaggtgca gtcttagcct caatcgcagg attcttaggt     4560

gcattaggct taagacgtgt taaaaaagat                                      4590


<210>  3
<211>  1335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of PrtV from Lactobacillus salivarius JCM1046

<400>  3

Asp Thr Val Asn Gly Ser Glu Ser Val Lys Thr Glu Ala Thr Gln Ala 
1               5                   10                  15      


Ser Gly Ser Ser Val Gln Asp Asn Ala Thr Ala Lys Thr Thr Val Thr 
            20                  25                  30          


Thr Asn Ser Asn Ser Ser Asn Asn Val Ser Asn Val Gln Thr Asp Thr 
        35                  40                  45              


Val Lys Glu Ala Ala Thr Ser Asn Val Asp Ser Val Ala Ser Gln Asn 
    50                  55                  60                  


Gln Ala Thr Thr Ala Gln Gln Ala Lys Thr Thr Ala Asp Thr Ala Asp 
65                  70                  75                  80  


Gln Thr Val Pro Pro Thr Thr Tyr Lys Asp His Val Lys Gly Asn Val 
                85                  90                  95      


Gln Thr Ala Trp Asp Asn Gly Tyr Lys Gly Gln Gly Met Val Val Ala 
            100                 105                 110         


Val Ile Asp Ser Gly Ala Asp Thr Asn His Lys Asp Phe Ser Lys Ala 
        115                 120                 125             


Pro Glu Ser Pro Ala Ile Ser Lys Glu Asp Ala Asp Lys Lys Ile Ser 
    130                 135                 140                 


Glu Leu Gly Tyr Gly Lys Tyr Ala Ser Glu Lys Phe Pro Phe Val Tyr 
145                 150                 155                 160 


Asn Tyr Ala Ser Arg Asp Asn Asn Trp Val Lys Asp Asp Gly Pro Asp 
                165                 170                 175     


Ala Ser Glu His Gly Gln His Val Ala Gly Ile Ile Gly Ala Asp Gly 
            180                 185                 190         


Gln Pro Asn Gly Asn Glu Arg Tyr Ala Val Gly Val Ala Pro Glu Thr 
        195                 200                 205             


Gln Leu Met Met Met Arg Val Phe Asn Asp Gln Phe Ala Asp Glu Asn 
    210                 215                 220                 


Thr Asp Asp Ile Ala Gln Ala Ile Tyr Asp Ala Val Lys Leu Gly Ala 
225                 230                 235                 240 


Asn Val Ile Gln Met Ser Leu Gly Gln Gly Val Ala Ala Ala Asn Leu 
                245                 250                 255     


Asn Asp Val Glu Gln Lys Ala Val Glu Tyr Ala Thr Gln His Gly Val 
            260                 265                 270         


Phe Val Ser Ile Ser Ala Ser Asn Asn Gly Asn Ser Ala Ser Val Thr 
        275                 280                 285             


Gly Glu Glu Val Pro Tyr Lys Pro Gly Gly Ala Asp Gly Asn Phe Glu 
    290                 295                 300                 


Pro Phe Ser Ser Ser Thr Val Ala Asn Pro Gly Ala Ser Arg Asn Ala 
305                 310                 315                 320 


Met Thr Val Ala Ala Glu Asn Ser Val Val Gly Ala Gly Asp Asp Met 
                325                 330                 335     


Ala Asp Phe Ser Ser Trp Gly Pro Leu Gln Asp Phe Thr Leu Lys Pro 
            340                 345                 350         


Asp Val Ser Ala Pro Gly Val Ser Val Thr Ser Thr Gly Asn Asp Asn 
        355                 360                 365             


Arg Tyr Asn Thr Met Ser Gly Thr Ser Met Ala Gly Pro Phe Asn Ala 
    370                 375                 380                 


Gly Val Ala Ala Leu Val Met Gln Arg Leu Lys Ala Thr Thr Asn Leu 
385                 390                 395                 400 


Asn Gly Ala Asp Leu Val Gln Ala Thr Lys Ala Leu Ile Met Asn Thr 
                405                 410                 415     


Ala Lys Pro Met Thr Gln Gln Gly Tyr Asp Thr Pro Val Ser Pro Arg 
            420                 425                 430         


Arg Gln Gly Ala Gly Glu Ile Asp Ala Gly Ala Ala Thr Glu Ser Pro 
        435                 440                 445             


Val Tyr Val Val Ala Ala Asp Gly Thr Ser Ser Val Ser Leu Arg Lys 
    450                 455                 460                 


Val Gly Asp Ser Thr Gln Phe Ala Leu Thr Phe Lys Asn Leu Ser Asp 
465                 470                 475                 480 


Lys Asp Gln Thr Tyr Thr Phe Asp Asp Phe Gly Gly Gly Leu Thr Glu 
                485                 490                 495     


Val Arg Asp Ala Asp Thr Gly Thr Phe His Asp Val Tyr Leu Ala Gly 
            500                 505                 510         


Ala His Val Tyr Gly Asn Lys Thr Val Thr Val Lys Ala Gly Gln Ser 
        515                 520                 525             


Ala Thr Tyr Asn Phe Thr Leu Ser Leu Thr Gly Leu Lys Glu Asn Gln 
    530                 535                 540                 


Leu Val Glu Gly Trp Leu Arg Phe Val Gly Asn Asp Gly Gln Asn Gln 
545                 550                 555                 560 


Leu Val Val Pro Tyr Leu Ala Tyr Tyr Gly Asp Met Thr Ser Glu Asp 
                565                 570                 575     


Val Phe Asp Lys Ala Ala Asn Gln Glu Gly Thr Val Tyr Gly Gly Asn 
            580                 585                 590         


Tyr Phe Val Asn Glu Asp Asn Tyr Pro Arg Gly Val Ala Asp Glu Asp 
        595                 600                 605             


Ser Leu Lys Ala Leu Val Asn Leu Glu Gly Asn Tyr Asn Trp Gln Gln 
    610                 615                 620                 


Val Ala Lys Leu Tyr Gln Asp Gly Lys Val Ala Phe Ser Pro Asn Ala 
625                 630                 635                 640 


Asp Gly Lys Ser Asp Leu Leu Lys Pro Tyr Ala Phe Val Lys Gln Asn 
                645                 650                 655     


Leu Lys Asp Leu Lys Val Glu Val Leu Asp Lys Ser Gly Lys Val Val 
            660                 665                 670         


Arg Val Val Ala Asp Glu Gln Gly Leu Asp Lys Ser Tyr Tyr Glu Ser 
        675                 680                 685             


Gly Val Asn Lys Asp Val Thr Leu Ser Val Ser Met Arg Asn Asn Pro 
    690                 695                 700                 


Asn Thr Leu Ala Trp Asp Gly Lys Val Tyr Asp Asp Lys Ala Gly Glu 
705                 710                 715                 720 


Met Val Asn Ala Ala Asp Gly Glu Tyr Thr Tyr Arg Tyr Val Ala Thr 
                725                 730                 735     


Leu Tyr Asn Asp Gly Val Asn Lys Val Gln Thr Ala Asp Tyr Pro Val 
            740                 745                 750         


Val Ile Asp Thr Thr Ala Pro Val Leu Ser Asn Val Lys Tyr Asp Ala 
        755                 760                 765             


Ala Thr His Thr Leu Ser Phe Asp Tyr Lys Asp Thr Gly Ser Gly Phe 
    770                 775                 780                 


Thr Asp Tyr Ser Tyr Ala Val Val Lys Val Asn Asp Lys Thr Phe Gly 
785                 790                 795                 800 


Tyr Lys Leu Asn Asp Gly Lys Asn Ser Lys Phe Leu Asp Ala Ala Lys 
                805                 810                 815     


Thr Ser Gly Thr Phe Lys Ala Val Leu Gly Ser Asp Thr Leu Ala Ala 
            820                 825                 830         


Leu Thr Ala Ala Lys Asn Ala Leu Ser Val Ala Val Ser Asp Val Ala 
        835                 840                 845             


Asp Asn Thr Ser Thr Val Thr Leu Leu Val Asn Gly Asn Asn Asp Ala 
    850                 855                 860                 


Thr Thr Lys Val Ser Val Trp Asn Ala Thr Asn Gly Leu Glu Leu Asp 
865                 870                 875                 880 


Gln Ser Ser Pro Asp Tyr Gln Ala Ala Thr Ser Thr Tyr Asn Leu Arg 
                885                 890                 895     


Gly Asn Ala Thr Ser Asp Phe Tyr Tyr Asn Gly Ala Leu Val Gln Val 
            900                 905                 910         


Asp Asn Ser Gly Asn Phe Val Val Pro Val Ser Thr Ser Asp Thr Ala 
        915                 920                 925             


Val Val Phe Thr Ser Asp Ala Ala Gly Lys Asn Val Val Tyr Lys Leu 
    930                 935                 940                 


Asn Thr Ala Thr Pro Lys Ala Val Phe Ala Trp Gln Val Asn Asn Thr 
945                 950                 955                 960 


Val Lys Glu Asn Phe Gly Ile Val Leu Asp Thr Val Val Ser Asn Asn 
                965                 970                 975     


Lys Asp Asp Val Val Val Gln Ala Ala Val Thr Lys Gly Asp Asn Val 
            980                 985                 990         


Glu Ala Tyr Ala Arg Asp Tyr Phe  Thr Gly Ala Val Tyr  Lys Ala Asp 
        995                 1000                 1005             


Val Lys  Asp Gly Leu Ala Thr  Phe His Val Lys Val  Thr Asn Asn 
    1010                 1015                 1020             


Ser Gly  Arg Thr Val Leu Leu  Gly Trp Thr Glu Val  Val Gly Pro 
    1025                 1030                 1035             


Thr Phe  Asn Asp Val Gln Arg  Thr Ser Ala Asn Gly  Val Tyr Leu 
    1040                 1045                 1050             


Gly Val  Asp Thr Asp Thr Glu  Asn Pro Thr Pro Ala  Pro Ala Phe 
    1055                 1060                 1065             


Thr Ser  Ala Asp Gln Leu Gly  Thr Asn Val Val Gln  Glu Lys Ala 
    1070                 1075                 1080             


Asp Ser  Ala Thr Ile Gly Asn  Pro Gly Asp Leu Pro  Gly His Ser 
    1085                 1090                 1095             


Leu Lys  Asp Leu Thr Thr Arg  Ala Asp Ala Asn Pro  Asp Ile His 
    1100                 1105                 1110             


Phe Asp  Tyr Leu Lys Asp Asn  Asp Tyr Asn Trp Val  Gly Ala Gln 
    1115                 1120                 1125             


Ala Val  Lys Asp Gly Val Tyr  Asn Pro Ser Thr Gln  Val Phe Thr 
    1130                 1135                 1140             


Leu Thr  Gly Lys Val Asp Pro  Asn Val Lys Ser Leu  Val Val Leu 
    1145                 1150                 1155             


Gly Asp  Ser Tyr Asn Glu Asp  Asp Pro Val Asn Lys  Val Asn Leu 
    1160                 1165                 1170             


Asn Ser  Asp Gly Thr Phe Ser  Phe Gln Phe His Thr  Ala Pro Thr 
    1175                 1180                 1185             


Ser Gln  Arg Pro Val Ala Tyr  Ile Tyr Thr Lys Asp  Asp Gly Ser 
    1190                 1195                 1200             


Thr Thr  Arg Gly Thr Met Glu  Leu Ile Leu Asp Thr  Val Leu Pro 
    1205                 1210                 1215             


Thr Leu  Ser Leu Asn Asn Val  Ala Asn Leu Gln Leu  Asp Ser Asn 
    1220                 1225                 1230             


Gly Asp  Tyr Gln Val Tyr Thr  Asn Asn Lys Asp Phe  Ser Val Ser 
    1235                 1240                 1245             


Gly Glu  Ala Thr Asp Asn Leu  Asp Gly Tyr Arg Phe  Phe Phe Asn 
    1250                 1255                 1260             


Gly Asp  Asn Asp Tyr Arg Glu  Phe His Asn Ser Gly  Val Asn Phe 
    1265                 1270                 1275             


Val Ala  Glu Ala His Gln Asp  Gly Ser Thr Val Thr  Asn Pro Tyr 
    1280                 1285                 1290             


Pro Ala  Tyr Lys Phe Ser Lys  Thr Phe Asn Leu Ala  Asp Ala Thr 
    1295                 1300                 1305             


Gly Glu  Thr Thr His Val Tyr  Thr Leu Ser Val Val  Asp Leu Thr 
    1310                 1315                 1320             


Gly Asn  Thr Val Thr Arg Lys  Phe Tyr Val His Tyr  
    1325                 1330                 1335 


<210>  4
<211>  4005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding fragment of PrtV

<400>  4
gataccgtta atggtagtga aagtgtaaaa acagaagcta ctcaggcatc aggttcgagt       60

gtgcaggata atgcgacagc taaaacaact gttacaacca atagtaatag ttctaacaat      120

gtttctaatg ttcaaactga taccgtaaaa gaagcagcaa cgagcaatgt tgattcagta      180

gctagtcaaa atcaagctac aacagctcaa caggctaaaa ctactgctga tactgctgat      240

cagacagtac caccaacaac ctataaagat catgtcaaag gaaatgttca aactgcatgg      300

gataatggct ataaaggaca aggtatggtg gttgctgtta ttgattctgg tgctgataca      360

aaccataaag atttctctaa agctcctgaa tctccagcaa tttctaagga agatgctgac      420

aagaagatta gcgagctagg ctacgggaaa tatgcttcag agaaattccc attcgtatat      480

aattatgcga gtcgtgacaa caactgggtt aaagatgatg gcccagatgc atcagaacac      540

ggtcaacacg ttgctggtat cattggtgct gacggccaac caaatggcaa tgaacgctat      600

gcagtagggg tagcacctga aacacagtta atgatgatgc gagtatttaa tgatcaattt      660

gctgatgaaa atactgatga tattgctcaa gcaatttatg acgcagttaa attaggtgct      720

aatgtaattc aaatgtcctt aggtcaaggc gtcgcagctg ctaatttgaa tgatgtagag      780

cagaaagcgg ttgaatatgc aactcaacat ggtgtgttcg tctccatttc agcttctaac      840

aatggtaatt cggcaagtgt tactggtgaa gaagttcctt ataaaccagg tggagcagat      900

ggaaactttg aaccattctc tagtagtacg gtagctaatc caggtgcatc gcgcaatgca      960

atgacagttg cagctgaaaa ctcggttgta ggtgctggtg atgacatggc agacttctct     1020

tcttggggtc ctttacaaga tttcactttg aaaccagatg tatcagctcc tggggttagt     1080

gtaacttcaa cagggaacga taatcgttac aatactatga gtggaacttc tatggctggt     1140

ccatttaacg ctggggttgc agctttagta atgcaaagat taaaagctac tactaactta     1200

aatggagcag atttagttca agctactaaa gctttaatca tgaatacagc taaaccaatg     1260

acgcaacaag gatatgacac tccagtttct cctagacgtc aaggtgctgg tgaaattgat     1320

gcaggtgctg caacagaatc tccagtatat gttgtggcag cagacggcac aagttctgta     1380

tctttgagaa aagttggaga ttcaactcaa ttcgcactaa cgtttaagaa cttatccgat     1440

aaagatcaaa catatacttt tgatgatttt ggtggtggat taactgaagt gcgcgatgcc     1500

gatacaggaa ctttccacga tgtttatctg gcaggagcac atgtctatgg aaataagaca     1560

gtaaccgtta aagctggaca aagcgcaact tataatttca cattatcttt aacaggtttg     1620

aaagaaaatc aattagttga aggttggttg agatttgtag gaaatgatgg tcaaaatcaa     1680

ttagtagttc catatctcgc atattatggt gatatgacaa gtgaagatgt atttgacaaa     1740

gctgctaatc aagaaggcac agtctatggt ggtaactact ttgttaatga agataactat     1800

ccaagagggg tagctgatga agattcctta aaggctttag taaatcttga aggtaattat     1860

aattggcaac aagttgctaa attataccaa gatggaaaag ttgcattctc accaaatgct     1920

gacggtaaga gtgacttatt aaaaccatat gcctttgtta aacaaaatct aaaggatctt     1980

aaagttgaag tattagataa gagtggaaaa gttgttcgtg tagttgcaga tgaacaaggt     2040

ctggataagt cttactatga aagtggagtt aataaagacg taactttatc agtttcaatg     2100

cgtaataatc caaatacttt ggcttgggat ggaaaagtat acgatgataa ggccggtgaa     2160

atggtaaatg cagcagatgg tgaatataca tatcgttatg ttgctacttt gtataatgat     2220

ggtgtaaata aggttcaaac agctgattat ccagtagtta tcgacacaac agctccagta     2280

ttatcaaatg ttaagtatga tgctgcaaca catactttaa gctttgatta taaagataca     2340

ggatctggct ttacagatta ttcttatgca gtagttaaag ttaatgataa gacatttggc     2400

tataagttaa atgatggcaa gaattcgaag ttcttagatg cagctaaaac atcaggaaca     2460

tttaaagccg tattaggtag tgatacttta gcagcactta ctgcagctaa gaatgcttta     2520

tcagttgcag ttagcgatgt agctgataat acttcaacag taaccttact ggtaaatgga     2580

aataatgatg caacaactaa agtatctgtt tggaatgcaa ctaatggatt agaactcgat     2640

caaagttccc cagattatca agcagcaact tcaacttata acttacgtgg gaatgcaaca     2700

tctgatttct attacaatgg tgcattagtt caagttgata acagtggtaa ttttgtggtt     2760

cctgtaagta caagtgatac tgcggttgtc ttcacatcag atgcagctgg taagaatgta     2820

gtatataaat tgaatacagc aactccaaag gctgtttttg catggcaagt aaataatact     2880

gttaaggaaa actttggtat tgttttagat acagtcgtaa gcaacaacaa ggatgatgta     2940

gtcgtacaag cagcggttac taagggggat aatgttgaag cttatgcacg cgactacttc     3000

acaggtgcag tatataaagc agatgtaaaa gatggattag caactttcca cgtaaaagta     3060

actaataata gtggtagaac tgtattatta ggatggacag aagttgtagg accaacattt     3120

aatgatgttc aaagaacttc tgcaaatggt gtttatttgg gtgttgatac agatacagag     3180

aatcctacgc cagcaccagc ctttacaagt gctgaccaat taggaacaaa tgttgttcaa     3240

gaaaaagctg attctgctac aattggtaat ccaggagatt tgccaggaca cagtctaaag     3300

gacctaacaa cacgtgcaga tgctaaccca gatatccact ttgactactt gaaagataat     3360

gattacaact gggtaggagc gcaagctgtt aaagatggtg tatataatcc atcaacacaa     3420

gtatttactt taacaggtaa ggttgatcca aatgttaaat cattggtggt attgggagat     3480

agttacaatg aagatgatcc tgtaaataag gttaacttaa atagtgatgg aacatttagt     3540

ttccaattcc atacagcacc aacttcacaa agacctgttg cttacatcta tacaaaagat     3600

gatggttcaa caactagagg tacaatggag ttaatcttag atacagttct tccaacactt     3660

agcttaaata atgtggctaa tttacaactg gatagtaatg gtgattacca agtctacact     3720

aataataaag actttagtgt atctggagaa gctactgata atttggacgg atatcgtttc     3780

ttcttcaatg gagataatga ttatcgtgaa ttccacaatt ctggtgtgaa ctttgttgct     3840

gaagctcatc aagatggaag tacagtgact aatccatatc cagcatacaa gtttagtaag     3900

acatttaact tagctgatgc aactggcgaa acaacacatg tatatacatt gagtgtagtt     3960

gacttgacag gtaatactgt aactaggaag ttctatgttc actat                     4005


<210>  5
<211>  1698
<212>  PRT
<213>  Lactobacillus intestinalis

<400>  5

Met Ser Asp Tyr Ser Trp Pro Lys Ser His Asn Lys Tyr Ser Tyr Val 
1               5                   10                  15      


Phe Lys Thr Arg Glu Gly Leu Asn Lys Ile Glu Thr Gln Lys Arg Ala 
            20                  25                  30          


Lys Ser Val Ser Asp Met Arg Lys Lys Trp Val Ala Thr Ala Ile Ile 
        35                  40                  45              


Ala Leu Ala Ser Gly Ser Thr Val Phe Leu Ser Gln Thr Ser Ser Val 
    50                  55                  60                  


Glu Ala Ala Ile Gly Glu Thr Ser Val Gln Asn Val Lys Val Ser Val 
65                  70                  75                  80  


Ala Lys Asn Glu Ser Asp Ser Gln Lys Phe Asn Asn Ser Gln Asn Leu 
                85                  90                  95      


Glu Gln Lys Thr Pro Gln Ala Ala Ala Ala Asn Gln Asn Gly Ser Gln 
            100                 105                 110         


Val Gln Asn Asp His Thr Glu Thr Gln Leu Gln Asn Gln Gln Thr Thr 
        115                 120                 125             


Gln Ser Gln Val Thr Gln Ala His Thr Glu Glu Asn Asn Ala Ser Ser 
    130                 135                 140                 


Ile Pro Glu Pro Ala Asn Gln Ala Asp His Val Lys Gly Asn Val Gln 
145                 150                 155                 160 


Ser Ala Trp Asp Gln Gly Tyr Lys Gly Gln Asn Thr Val Val Ala Val 
                165                 170                 175     


Ile Asp Ser Gly Ala Asp Thr Ser His Lys Asp Phe Gln Thr Met Pro 
            180                 185                 190         


Ser Asn Pro Lys Leu Lys Gln Glu Asp Val Gln Ser Lys Ile Asp Gln 
        195                 200                 205             


Gln Gly Tyr Gly Lys Tyr Val Asn Glu Lys Phe Pro Tyr Val Tyr Asn 
    210                 215                 220                 


Tyr Ala Asp Arg Asp Asn Asp Tyr Ile Lys Ser Asp Asp Asn Asn Gln 
225                 230                 235                 240 


Asn Asp Ser Pro His Gly Gln His Val Ser Gly Ile Ile Ala Ala Asp 
                245                 250                 255     


Gly His Pro Glu Gly Asp Gln Gln Tyr Val Val Gly Val Ala Pro Glu 
            260                 265                 270         


Ala Gln Leu Met Gln Leu Arg Val Phe Gly Gln Phe Ser Asp Glu Lys 
        275                 280                 285             


Thr Asp Asp Val Ala Arg Ala Ile Tyr Asp Ala Thr Asn Leu Gly Ala 
    290                 295                 300                 


Asp Val Ile Gln Met Ser Leu Gly Gln Gly Val Ala Asp Gln Gln Leu 
305                 310                 315                 320 


Thr Asn Ile Glu Gln Lys Ala Val Gln Tyr Ala Ile Asp His Gly Val 
                325                 330                 335     


Phe Val Ser Ile Ser Ala Ser Asn Asn Gly Asn Ser Ala Ser Val Asp 
            340                 345                 350         


Asn Pro Ser Lys Val Thr Ala Lys Gly Tyr Gly Ser Gly Ser Glu Ala 
        355                 360                 365             


Gly Asn Tyr Glu Pro Leu Asn Ser Gly Thr Val Ala Asn Pro Gly Ala 
    370                 375                 380                 


Ser Lys Asn Ala Leu Thr Val Ala Ala Glu Thr Ser Gly Thr Gly Lys 
385                 390                 395                 400 


Asp Ser Asp Met Ala Ser Phe Ser Ser Trp Gly Pro Leu Ser Asp Phe 
                405                 410                 415     


Ser Leu Lys Pro Asp Leu Ser Ala Pro Gly Tyr Gln Val Val Ser Thr 
            420                 425                 430         


Val Asn Asp Asn Gln Tyr Gln Thr Met Ser Gly Thr Ser Met Ala Gly 
        435                 440                 445             


Pro Phe Ala Ala Gly Ser Ala Ala Leu Val Ile Gln Arg Leu Lys Gln 
    450                 455                 460                 


Thr Asn Pro Glu Leu Lys Gly Ala Glu Leu Val Ala Ala Thr Lys Ala 
465                 470                 475                 480 


Leu Leu Met Asn Ser Ala Lys Val Gln Thr Gln Asn Gly Tyr Thr Thr 
                485                 490                 495     


Pro Val Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Gly Ala 
            500                 505                 510         


Ala Thr Ala Asn Pro Val Tyr Val Thr Ala Ala Asp Gly Thr Ser Ser 
        515                 520                 525             


Leu Ser Leu Arg Gln Val Asp Glu Lys Thr Thr Phe Thr Leu Thr Phe 
    530                 535                 540                 


His Asn Leu Thr Asp Gln Glu Gln Ser Tyr Ser Phe Asn Asp Leu Gly 
545                 550                 555                 560 


Gly Gly Tyr Thr Glu Gln Arg Asp Pro Asp Ser Gly Val Phe His Glu 
                565                 570                 575     


Val Gln Leu Ala Gly Ala His Val Asn Gly Val Gly Asn Phe Thr Leu 
            580                 585                 590         


Ala Pro Lys Glu Val Lys Asp Leu Gln Tyr Thr Leu Asp Leu Gln Gly 
        595                 600                 605             


Leu Asn Lys Asn Gln Pro Val Glu Gly Trp Leu His Phe Thr Asn Asp 
    610                 615                 620                 


Lys Asp Lys Ser Thr Val Val Val Pro Tyr Leu Ala Tyr Tyr Gly Asp 
625                 630                 635                 640 


Leu Thr Ser Glu Asn Val Phe Asp Gln Asn Ala Asn Glu Glu Lys Pro 
                645                 650                 655     


Asp Ile Gln Gly Asn Arg Phe Val Asn Glu Asn Asn Tyr Pro Leu Gly 
            660                 665                 670         


Val Thr Asp Gln Glu Ser Leu Lys Gln Leu Val Asn Val Asp Ser Asp 
        675                 680                 685             


Tyr Asn Trp Gln Glu Val Ala Lys Leu Tyr Glu Ser Gly Lys Val Ala 
    690                 695                 700                 


Phe Ser Pro Asn Asp Asp His Gln Ser Asp Leu Ile Lys Pro Tyr Ala 
705                 710                 715                 720 


Tyr Leu Lys Gln Asn Val Lys Asp Leu Lys Val Glu Ile Leu Asp Ala 
                725                 730                 735     


Lys Gly Asn Val Val Arg Val Val Ser Asp Val Gln Gly Val Asp Lys 
            740                 745                 750         


Ser Tyr Asp Glu Ser Gly Val Thr Lys Asp Ala Ser Leu Ser Val Ser 
        755                 760                 765             


Met Arg Asp Asn Pro Asp Ala Phe Glu Trp Asp Gly Lys Val Tyr Asp 
    770                 775                 780                 


Thr Lys Thr Gly Gln Met Val Thr Ala Pro Asp Gly Gln Tyr Thr Tyr 
785                 790                 795                 800 


Arg Phe Val Ala Thr Leu Trp Asn Glu Gly Pro Asn Gln Lys Gln Thr 
                805                 810                 815     


Ala Asp Phe Pro Val Val Val Asp Thr Gln Ala Pro Ser Leu Ser Val 
            820                 825                 830         


Lys Tyr Asp Ser Ala Thr His Thr Leu Ser Gly Asn Tyr Glu Asp Lys 
        835                 840                 845             


Gly Ala Gly Phe Thr Asp Tyr Ser Tyr Val Thr Val Gln Val Asn Asp 
    850                 855                 860                 


Lys Val Phe Gly Tyr Lys Leu Asn Glu Gly Glu Ser Gly Phe Asp Asn 
865                 870                 875                 880 


Ser Glu Lys Thr Lys Gly His Phe Asn Phe Thr Leu Ser Ser Asp Ala 
                885                 890                 895     


Leu Asp Ala Leu Ser Gly Ser Leu Asn Lys Val Ser Val Thr Leu Ser 
            900                 905                 910         


Asp Val Ala Asn Asn Thr Thr Val Lys Thr Val Asp Val Pro Ala Val 
        915                 920                 925             


Lys Asp Gln Pro Ala Val Ser Val Trp Asn Ala Thr Glu Gly Val Glu 
    930                 935                 940                 


Phe Asn Lys Asn Ser Lys Asp Tyr Asn Lys Glu Asn Asp Thr Tyr Thr 
945                 950                 955                 960 


Leu Tyr Gly Ser Ala Ala Gln Asp Phe Tyr Leu Asn Gly Ala Leu Val 
                965                 970                 975     


Gln Val Arg Asp Gly Lys Tyr Glu Val Pro Val Lys Thr Thr Thr Gln 
            980                 985                 990         


Asp Leu Val Phe Ser Thr Asp Gln  Ala Gly Lys Asn Val  Leu Lys Ser 
        995                 1000                 1005             


Phe Thr  Thr Phe Thr Pro Lys  Ala Phe Phe Asn Trp  Gln Asn Val 
    1010                 1015                 1020             


Asp Gly  Phe Asp Gly Asn Phe  Gly Val Asn Ile Tyr  Ser Val Lys 
    1025                 1030                 1035             


Thr Asn  Asp Pro Asn Asn Ala  Val Val Gln Ala Ala  Val Pro Leu 
    1040                 1045                 1050             


Gly Lys  Asn Val Lys Ala Tyr  Ala Gln Asp Tyr Phe  Thr Gly Glu 
    1055                 1060                 1065             


Val Tyr  Lys Gly Gln Val Glu  Asn Gly Val Ala Thr  Phe His Val 
    1070                 1075                 1080             


His Thr  Ser Ile Asn Gln Gly  Glu Asp Gly Ile Phe  Lys Arg Ala 
    1085                 1090                 1095             


Leu Leu  Thr Gly Trp Ser Glu  Val Asp Gly Pro Ala  Tyr Asn Asp 
    1100                 1105                 1110             


Lys Gln  Val Thr Ser Lys Ala  Gly Val Ala Ser Ser  Asn His Leu 
    1115                 1120                 1125             


Gly Val  Tyr Tyr Thr Thr Asp  Lys Val Asn Arg Lys  Val Tyr Thr 
    1130                 1135                 1140             


Asp Arg  Ala Asp Leu Gly Val  Asp Val Gln Asp Glu  Ala Ala Asp 
    1145                 1150                 1155             


Leu Ser  Ser Phe Gly Pro Thr  Ala Tyr Pro Gly His  Ala Leu Ala 
    1160                 1165                 1170             


Asp Leu  Thr Thr Arg Thr Asp  Pro Asn Pro Ala Ile  His Phe Asp 
    1175                 1180                 1185             


Tyr Leu  Asn Asp Asn Asp Thr  Thr Arg Phe Gly Gln  Asn Ala Val 
    1190                 1195                 1200             


Thr Asp  Gly Tyr Tyr Asp Ser  Val Thr Lys Lys Phe  Thr Val Thr 
    1205                 1210                 1215             


Gly His  Val Asp Pro Glu Val  Lys Ser Leu Thr Val  Leu Gly Asp 
    1220                 1225                 1230             


Ser Ser  Asp Glu Asn Ala Pro  Gln Asn Gln Val Lys  Leu Gly Lys 
    1235                 1240                 1245             


Asp Gly  Lys Phe Ser Phe Ser  Phe Thr Thr Glu Asn  Val Gly Gln 
    1250                 1255                 1260             


Arg Pro  Val Ala Tyr Ile Tyr  Thr Asp Gln Asn Gly  Gln Lys Val 
    1265                 1270                 1275             


Arg Gly  Thr Leu Asn Val Val  Leu Asp Thr Val Ala  Pro Thr Leu 
    1280                 1285                 1290             


Asn Val  Asp Gln Val Asn Gly  Asn Glu Leu Glu Val  Lys Thr Asn 
    1295                 1300                 1305             


Asn Pro  Leu Phe Lys Leu Ser  Gly Val Val Asn Asp  Asn Leu Asp 
    1310                 1315                 1320             


Gly Tyr  Arg Leu Tyr Val Asn  Gly Asn Asn Ile Tyr  Arg Glu Phe 
    1325                 1330                 1335             


Leu Asn  Ser Gly Tyr Asn Lys  Leu Ala Gly Leu Asn  Thr Asp Gly 
    1340                 1345                 1350             


Thr Asp  Val Asn Pro Tyr Gly  Pro His Asn Phe Glu  Glu Ser Phe 
    1355                 1360                 1365             


Asn Leu  Asn Asp Asp Asn Asn  Gln Pro Thr Thr His  Val Phe Thr 
    1370                 1375                 1380             


Ile Tyr  Val Val Asp Gln Val  Gly Asn Lys Val Glu  Lys Lys Ile 
    1385                 1390                 1395             


Ala Val  Asn Tyr Asp Pro Asp  Tyr Val Ala Glu Pro  Pro Lys Thr 
    1400                 1405                 1410             


Asp Gln  Asp Gln Asn Ser Gly  Gln Thr Ala Gln Pro  Gln Thr Asn 
    1415                 1420                 1425             


Pro Ala  Val Asn Val Asp Lys  Pro Thr Thr Pro Asp  Asn Thr Ser 
    1430                 1435                 1440             


Glu Val  Pro Ala Val Asp Gln  Thr Lys His Ser Asp  Ser Glu Gln 
    1445                 1450                 1455             


Thr Asn  Gln Val Pro Lys Asp  Asn Pro Thr Asp Gln  Leu Ser Val 
    1460                 1465                 1470             


Gln Val  Pro Val Ser Arg Glu  Thr Ser Val Thr Lys  Asp Asn Asn 
    1475                 1480                 1485             


Leu Asn  Asp Val Val Leu Thr  Ala Lys Ser Phe Pro  Leu Leu His 
    1490                 1495                 1500             


Asp Ala  Tyr Leu Tyr Asp Glu  Asn Gly Glu Val Val  Leu Thr Ser 
    1505                 1510                 1515             


Asp Pro  Gln Lys Lys Ser Val  Leu Lys Lys Gly Lys  Thr Ile Ser 
    1520                 1525                 1530             


Ala Leu  Gln Asn Gly His Val  Tyr Val Ile Lys Gly  Val Lys Phe 
    1535                 1540                 1545             


Tyr Gln  Val Gly Lys Asn Gln  Tyr Val Lys Val Ala  Asn Thr Thr 
    1550                 1555                 1560             


Leu Gln  Ala Gly Lys Arg Leu  Gln Leu Lys His Asn  Ala Phe Val 
    1565                 1570                 1575             


Tyr Asp  Glu Lys Gly Lys Leu  Val Lys Lys His Gly  Lys Ser Val 
    1580                 1585                 1590             


Leu Leu  Pro Lys Asn Lys Trp  Val Ser Ala Leu Asn  Asn Ala Asp 
    1595                 1600                 1605             


Lys Phe  Lys Val Asn Gly Val  Thr Tyr Tyr Lys Leu  Thr Asp His 
    1610                 1615                 1620             


Gln Tyr  Ile Lys Val Ala Asn  Thr Val Val Gln Pro  Ala Lys Lys 
    1625                 1630                 1635             


Leu Lys  Leu Thr His Asn Ala  Phe Val Tyr Asp Gln  Asn Gly Lys 
    1640                 1645                 1650             


Arg Val  Lys Lys Ser Lys Leu  Leu Lys Lys Gly Thr  Val Leu Leu 
    1655                 1660                 1665             


Ala Leu  Asn Gly Ala Glu Lys  Phe Lys Leu Lys Asn  Lys Thr Tyr 
    1670                 1675                 1680             


Tyr Gln  Val Gly Lys Asn Gln  Tyr Val Lys Val Ala  Asn Thr Leu 
    1685                 1690                 1695             


<210>  6
<211>  5094
<212>  DNA
<213>  Lactobacillus intestinalis

<400>  6
atgagtgatt atagctggcc aaagagccac aataagtatt cttatgtttt caaaacaaga       60

gaaggcttaa acaagattga aacacaaaaa cgtgcgaaga gcgtttcaga tatgcgaaag      120

aaatgggtgg ctacagctat tattgcttta gcatctggtt cgactgtctt tttgagtcag      180

acatcttctg ttgaagcagc aataggagag acttctgtcc aaaatgttaa agtttctgtg      240

gctaaaaatg aaagtgattc acaaaaattt aataatagtc agaacttgga acaaaaaact      300

ccgcaagcag cagctgctaa tcaaaatggg tcacaagtac aaaatgacca tactgaaact      360

caattacaaa accaacaaac tactcaatct caggtaactc aagctcacac agaagaaaat      420

aatgcttcat caattcctga accagctaat caggccgatc atgtaaaagg aaatgttcaa      480

tctgcatggg accagggtta taaaggtcaa aatacggttg tagccgtaat tgattctggg      540

gctgatacca gtcataaaga tttccaaaca atgccatcta atccaaaact taagcaagaa      600

gatgttcaaa gtaagattga tcagcaagga tatggaaaat atgttaatga aaaatttcca      660

tatgtttata attatgccga tagggacaat gattatatta aatcggatga taataatcaa      720

aatgatagtc ctcatgggca acatgtttct ggaattattg cggcagatgg gcaccctgag      780

ggtgatcaac aatatgttgt cggagttgct ccagaagctc agcttatgca acttagagta      840

tttgggcaat tttctgatga aaaaacagat gatgtagcaa gagctatcta tgatgcaact      900

aacttaggtg ccgatgttat ccaaatgtcc ttaggacagg gtgtggcaga tcaacagtta      960

actaatattg aacaaaaagc agttcaatat gcgattgacc atggtgtatt tgtttcaatt     1020

tctgcttcta ataatggaaa ttctgcttca gtagataatc caagtaaagt taccgcaaaa     1080

ggttatgggt ccggatcaga agctggaaat tatgaacctt tgaattctgg aacggtcgcc     1140

aaccccggtg cttctaagaa tgccttaact gttgctgcgg aaacttctgg aactggcaaa     1200

gatagtgaca tggcttcatt ttcatcatgg ggaccattat ctgattttag tttaaagcca     1260

gatctttcag ctcctggtta tcaggtggtt tcaactgtta atgataatca atatcaaaca     1320

atgagtggaa cttcaatggc tggtccattt gcagctggca gtgctgcttt agtaatccaa     1380

cggctaaagc aaactaatcc agagttaaaa ggagcagaac ttgttgctgc aactaaagca     1440

ttattgatga atagcgctaa agtgcaaacg caaaatggat acaccacgcc tgtttctcca     1500

agaagacaag gtgcaggtca aattgatgta ggagctgcta cggccaatcc agtttatgta     1560

actgctgctg atggaacgag ctccttatct ttacgtcaag ttgatgaaaa aactactttt     1620

actcttactt ttcataattt aacagatcaa gaacaaagct acagctttaa tgatttgggg     1680

ggaggttata ctgaacaacg tgatcccgat agtggggtct ttcatgaggt tcaattagca     1740

ggagctcatg tgaatggtgt aggcaatttt actctagcac caaaagaggt taaagacctt     1800

caatatacat tagatttaca ggggttaaat aaaaatcagc cagtagaagg atggcttcat     1860

tttactaatg ataaagataa atcgactgtg gtagtgccat atttagcata ttatggtgat     1920

ttgactagtg aaaatgtctt cgatcaaaat gcaaatgaag aaaagccaga tattcaaggt     1980

aatcgtttcg ttaatgaaaa caattatcca cttggagtaa ctgatcaaga atctttaaaa     2040

caattagtaa atgttgacag tgattacaat tggcaagaag ttgctaaact ttacgaaagt     2100

ggaaaagttg ctttttcacc aaatgatgat catcaaagtg accttatcaa gccatatgct     2160

tatttaaagc aaaatgtaaa agacttaaag gttgaaattt tagacgctaa gggtaacgta     2220

gtgcgcgtag tatctgatgt tcaaggggtt gataagtctt acgatgaaag tggagtaact     2280

aaagatgcta gtctttcagt ctccatgaga gacaatcccg atgcttttga atgggacggt     2340

aaagtttacg atactaaaac tggtcaaatg gtaacggcgc ccgatggaca atatacttat     2400

cgctttgttg ctactctctg gaatgaagga ccaaatcaaa aacagactgc agattttcca     2460

gttgtagtag atacacaagc tcctagttta agcgttaaat atgattcggc tactcatact     2520

ttgtccggta actatgaaga taagggtgca ggttttacgg attattctta tgttactgtc     2580

caagtaaatg ataaagtctt tggttacaag ttgaatgagg gcgaatcagg ttttgacaac     2640

agtgaaaaaa caaaaggtca tttcaatttt actttaagtt cagatgcttt ggatgcttta     2700

agtggtagtt tgaataaagt ttctgtaact ttaagtgatg tagctaacaa cacgacagtt     2760

aaaactgttg atgttcctgc tgttaaagat caaccagcag tttctgtgtg gaatgcaacc     2820

gaaggggtag aatttaataa aaattctaaa gactacaata aagaaaatga tacttacact     2880

ttatatggtt cagcggccca agatttctat ttaaatggtg ccttagtgca agtacgagat     2940

ggcaaatacg aggttccagt aaaaacgact acccaagatt tggtattttc tactgatcaa     3000

gcaggtaaaa atgttttaaa gtctttcact acttttaccc ctaaggcatt ctttaattgg     3060

caaaatgtcg atggctttga cgggaatttt ggagtaaata tctattctgt gaagactaat     3120

gatccaaata atgcagttgt gcaagcagca gttcctctag gtaaaaatgt caaagcctat     3180

gctcaagact atttcactgg tgaagtatat aaaggccaag tagaaaatgg agtagctact     3240

ttccatgtgc atacttctat taatcaaggc gaagacggta tatttaaacg tgcgctttta     3300

acagggtgga gtgaagtgga cggtccggca tataatgata aacaagttac cagtaaagct     3360

ggtgtagcta gttcaaatca tttaggtgtt tattacacca ctgataaggt taatcgaaag     3420

gtttatactg atcgcgctga tttaggtgta gatgttcaag atgaagcagc tgacttaagt     3480

tcatttggcc caaccgcata cccaggacat gctctagcag atttaactac tcgaacggat     3540

cctaatccag caattcattt tgattatttg aatgataatg acactactag atttggacaa     3600

aatgcagtga ctgatggata ttatgattcc gtaactaaaa agtttactgt tacaggacat     3660

gtcgatccag aagttaaatc gcttactgtc ttaggagata gttctgatga aaatgctcct     3720

caaaatcaag tcaagttggg caaagatggc aagttcagtt ttagtttcac tactgaaaat     3780

gtaggccaac gtcccgtagc ttatatttat actgatcaaa atggtcaaaa agttcgcggt     3840

accctaaatg ttgtcttaga tacagttgcg ccaaccttaa atgtagatca agtaaatggt     3900

aacgaacttg aagtcaaaac taacaatcct cttttcaaac tttcaggagt agttaatgat     3960

aatttagatg gctatagact ttatgtaaat ggcaataata tttatcgaga attcttaaat     4020

tctggctaca ataaattagc aggtttaaat actgatggga cagatgtaaa cccatatggt     4080

ccgcataact ttgaagaaag tttcaattta aatgatgaca acaatcaacc aactactcat     4140

gtctttacga tttacgtagt tgaccaagtt ggtaataaag tagaaaagaa gatcgctgtt     4200

aattatgatc cagactatgt ggctgaacct ccaaaaacgg atcaagatca aaattctggt     4260

cagactgcac aaccgcaaac aaatccagca gtaaatgttg ataagcctac cactccagat     4320

aacacatctg aagttccagc tgttgatcaa accaaacatt cagatagtga gcaaactaat     4380

caagttccaa aggataatcc gacagatcaa ctctctgttc aagttcctgt ttcacgtgaa     4440

actagtgtta caaaagataa taatcttaat gatgtagttt taacggctaa atcattcccg     4500

cttcttcatg atgcatattt atatgatgaa aatggggaag tcgttttaac tagtgatcca     4560

cagaagaaat cagttttgaa gaaaggcaag acaatcagtg cgcttcaaaa tggacatgtt     4620

tatgtaatta aaggtgtaaa attctaccaa gttggtaaga atcagtatgt aaaggtcgcc     4680

aacactactt tgcaagctgg taagagattg caattaaagc ataatgcctt tgtttatgat     4740

gaaaaaggaa agctggttaa gaagcatggc aagagtgtac ttttaccaaa aaataagtgg     4800

gtttcagctt taaataatgc agacaagttt aaagtaaatg gtgtaactta ttataaactt     4860

acggatcatc aatatatcaa agttgctaat accgtcgttc aaccagctaa gaaacttaag     4920

ttaactcata atgcctttgt ttatgatcaa aatggcaaac gagttaaaaa gagtaagctt     4980

ttaaagaagg gcacagtgct tttggcctta aatggagctg aaaagtttaa gctcaagaat     5040

aagacttact atcaagttgg taagaatcaa tatgtaaaag tcgctaatac ttta           5094


<210>  7
<211>  1343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of PrtI from Lactobacillus intestinalis DSM6629


<220>
<221>  misc_feature
<222>  (175)..(175)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Ala Ile Gly Glu Thr Ser Val Gln Asn Val Lys Val Ser Val Ala Lys 
1               5                   10                  15      


Asn Glu Ser Asp Ser Gln Lys Phe Asn Asn Ser Gln Asn Leu Glu Gln 
            20                  25                  30          


Lys Thr Pro Gln Ala Ala Ala Ala Asn Gln Asn Gly Ser Gln Val Gln 
        35                  40                  45              


Asn Asp His Thr Glu Thr Gln Leu Gln Asn Gln Gln Thr Thr Gln Ser 
    50                  55                  60                  


Gln Val Thr Gln Ala His Thr Glu Glu Asn Asn Ala Ser Ser Ile Pro 
65                  70                  75                  80  


Glu Pro Ala Asn Gln Ala Asp His Val Lys Gly Asn Val Gln Ser Ala 
                85                  90                  95      


Trp Asp Gln Gly Tyr Lys Gly Gln Asn Thr Val Val Ala Val Ile Asp 
            100                 105                 110         


Ser Gly Ala Asp Thr Ser His Lys Asp Phe Gln Thr Met Pro Ser Asn 
        115                 120                 125             


Pro Lys Leu Lys Gln Glu Asp Val Gln Ser Lys Ile Asp Gln Gln Gly 
    130                 135                 140                 


Tyr Gly Lys Tyr Val Asn Glu Lys Phe Pro Tyr Val Tyr Asn Tyr Ala 
145                 150                 155                 160 


Asp Arg Asp Asn Asp Tyr Ile Lys Ser Asp Asp Asn Asn Gln Xaa Asn 
                165                 170                 175     


Asp Ser Pro His Gly Gln His Val Ser Gly Ile Ile Ala Ala Asp Gly 
            180                 185                 190         


His Pro Glu Gly Asp Gln Gln Tyr Val Val Gly Val Ala Pro Glu Ala 
        195                 200                 205             


Gln Leu Met Gln Leu Arg Val Phe Gly Gln Phe Ser Asp Glu Lys Thr 
    210                 215                 220                 


Asp Asp Val Ala Arg Ala Ile Tyr Asp Ala Thr Asn Leu Gly Ala Asp 
225                 230                 235                 240 


Val Ile Gln Met Ser Leu Gly Gln Gly Val Ala Asp Gln Gln Leu Thr 
                245                 250                 255     


Asn Ile Glu Gln Lys Ala Val Gln Tyr Ala Ile Asp His Gly Val Phe 
            260                 265                 270         


Val Ser Ile Ser Ala Ser Asn Asn Gly Asn Ser Ala Ser Val Asp Asn 
        275                 280                 285             


Pro Ser Lys Val Thr Ala Lys Gly Tyr Gly Ser Gly Ser Glu Ala Gly 
    290                 295                 300                 


Asn Tyr Glu Pro Leu Asn Ser Gly Thr Val Ala Asn Pro Gly Ala Ser 
305                 310                 315                 320 


Lys Asn Ala Leu Thr Val Ala Ala Glu Thr Ser Gly Thr Gly Lys Asp 
                325                 330                 335     


Ser Asp Met Ala Ser Phe Ser Ser Trp Gly Pro Leu Ser Asp Phe Ser 
            340                 345                 350         


Leu Lys Pro Asp Leu Ser Ala Pro Gly Tyr Gln Val Val Ser Thr Val 
        355                 360                 365             


Asn Asp Asn Gln Tyr Gln Thr Met Ser Gly Thr Ser Met Ala Gly Pro 
    370                 375                 380                 


Phe Ala Ala Gly Ser Ala Ala Leu Val Ile Gln Arg Leu Lys Gln Thr 
385                 390                 395                 400 


Asn Pro Glu Leu Lys Gly Ala Glu Leu Val Ala Ala Thr Lys Ala Leu 
                405                 410                 415     


Leu Met Asn Ser Ala Lys Val Gln Thr Gln Asn Gly Tyr Thr Thr Pro 
            420                 425                 430         


Val Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Gly Ala Ala 
        435                 440                 445             


Thr Ala Asn Pro Val Tyr Val Thr Ala Ala Asp Gly Thr Ser Ser Leu 
    450                 455                 460                 


Ser Leu Arg Gln Val Asp Glu Lys Thr Thr Phe Thr Leu Thr Phe His 
465                 470                 475                 480 


Asn Leu Thr Asp Gln Glu Gln Ser Tyr Ser Phe Asn Asp Leu Gly Gly 
                485                 490                 495     


Gly Tyr Thr Glu Gln Arg Asp Pro Asp Ser Gly Val Phe His Glu Val 
            500                 505                 510         


Gln Leu Ala Gly Ala His Val Asn Gly Val Gly Asn Phe Thr Leu Ala 
        515                 520                 525             


Pro Lys Glu Val Lys Asp Leu Gln Tyr Thr Leu Asp Leu Gln Gly Leu 
    530                 535                 540                 


Asn Lys Asn Gln Pro Val Glu Gly Trp Leu His Phe Thr Asn Asp Lys 
545                 550                 555                 560 


Asp Lys Ser Thr Val Val Val Pro Tyr Leu Ala Tyr Tyr Gly Asp Leu 
                565                 570                 575     


Thr Ser Glu Asn Val Phe Asp Gln Asn Ala Asn Glu Glu Lys Pro Asp 
            580                 585                 590         


Ile Gln Gly Asn Arg Phe Val Asn Glu Asn Asn Tyr Pro Leu Gly Val 
        595                 600                 605             


Thr Asp Gln Glu Ser Leu Lys Gln Leu Val Asn Val Asp Ser Asp Tyr 
    610                 615                 620                 


Asn Trp Gln Glu Val Ala Lys Leu Tyr Glu Ser Gly Lys Val Ala Phe 
625                 630                 635                 640 


Ser Pro Asn Asp Asp His Gln Ser Asp Leu Ile Lys Pro Tyr Ala Tyr 
                645                 650                 655     


Leu Lys Gln Asn Val Lys Asp Leu Lys Val Glu Ile Leu Asp Ala Lys 
            660                 665                 670         


Gly Asn Val Val Arg Val Val Ser Asp Val Gln Gly Val Asp Lys Ser 
        675                 680                 685             


Tyr Asp Glu Ser Gly Val Thr Lys Asp Ala Ser Leu Ser Val Ser Met 
    690                 695                 700                 


Arg Asp Asn Pro Asp Ala Phe Glu Trp Asp Gly Lys Val Tyr Asp Thr 
705                 710                 715                 720 


Lys Thr Gly Gln Met Val Thr Ala Pro Asp Gly Gln Tyr Thr Tyr Arg 
                725                 730                 735     


Phe Val Ala Thr Leu Trp Asn Glu Gly Pro Asn Gln Lys Gln Thr Ala 
            740                 745                 750         


Asp Phe Pro Val Val Val Asp Thr Gln Ala Pro Ser Leu Ser Val Lys 
        755                 760                 765             


Tyr Asp Ser Ala Thr His Thr Leu Ser Gly Asn Tyr Glu Asp Lys Gly 
    770                 775                 780                 


Ala Gly Phe Thr Asp Tyr Ser Tyr Val Thr Val Gln Val Asn Asp Lys 
785                 790                 795                 800 


Val Phe Gly Tyr Lys Leu Asn Glu Gly Glu Ser Gly Phe Asp Asn Ser 
                805                 810                 815     


Glu Lys Thr Lys Gly His Phe Asn Phe Thr Leu Ser Ser Asp Ala Leu 
            820                 825                 830         


Asp Ala Leu Ser Gly Ser Leu Asn Lys Val Ser Val Thr Leu Ser Asp 
        835                 840                 845             


Val Ala Asn Asn Thr Thr Val Lys Thr Val Asp Val Pro Ala Val Lys 
    850                 855                 860                 


Asp Gln Pro Ala Val Ser Val Trp Asn Ala Thr Glu Gly Val Glu Phe 
865                 870                 875                 880 


Asn Lys Asn Ser Lys Asp Tyr Asn Lys Glu Asn Asp Thr Tyr Thr Leu 
                885                 890                 895     


Tyr Gly Ser Ala Ala Gln Asp Phe Tyr Leu Asn Gly Ala Leu Val Gln 
            900                 905                 910         


Val Arg Asp Gly Lys Tyr Glu Val Pro Val Lys Thr Thr Thr Gln Asp 
        915                 920                 925             


Leu Val Phe Ser Thr Asp Gln Ala Gly Lys Asn Val Leu Lys Ser Phe 
    930                 935                 940                 


Thr Thr Phe Thr Pro Lys Ala Phe Phe Asn Trp Gln Asn Val Asp Gly 
945                 950                 955                 960 


Phe Asp Gly Asn Phe Gly Val Asn Ile Tyr Ser Val Lys Thr Asn Asp 
                965                 970                 975     


Pro Asn Asn Ala Val Val Gln Ala Ala Val Pro Leu Gly Lys Asn Val 
            980                 985                 990         


Lys Ala Tyr Ala Gln Asp Tyr Phe  Thr Gly Glu Val Tyr  Lys Gly Gln 
        995                 1000                 1005             


Val Glu  Asn Gly Val Ala Thr  Phe His Val His Thr  Ser Ile Asn 
    1010                 1015                 1020             


Gln Gly  Glu Asp Gly Ile Phe  Lys Arg Ala Leu Leu  Thr Gly Trp 
    1025                 1030                 1035             


Ser Glu  Val Asp Gly Pro Ala  Tyr Asn Asp Lys Gln  Val Thr Ser 
    1040                 1045                 1050             


Lys Ala  Gly Val Ala Ser Ser  Asn His Leu Gly Val  Tyr Tyr Thr 
    1055                 1060                 1065             


Thr Asp  Lys Val Asn Arg Lys  Val Tyr Thr Asp Arg  Ala Asp Leu 
    1070                 1075                 1080             


Gly Val  Asp Val Gln Asp Glu  Ala Ala Asp Leu Ser  Ser Phe Gly 
    1085                 1090                 1095             


Pro Thr  Ala Tyr Pro Gly His  Ala Leu Ala Asp Leu  Thr Thr Arg 
    1100                 1105                 1110             


Thr Asp  Pro Asn Pro Ala Ile  His Phe Asp Tyr Leu  Asn Asp Asn 
    1115                 1120                 1125             


Asp Thr  Thr Arg Phe Gly Gln  Asn Ala Val Thr Asp  Gly Tyr Tyr 
    1130                 1135                 1140             


Asp Ser  Val Thr Lys Lys Phe  Thr Val Thr Gly His  Val Asp Pro 
    1145                 1150                 1155             


Glu Val  Lys Ser Leu Thr Val  Leu Gly Asp Ser Ser  Asp Glu Asn 
    1160                 1165                 1170             


Ala Pro  Gln Asn Gln Val Lys  Leu Gly Lys Asp Gly  Lys Phe Ser 
    1175                 1180                 1185             


Phe Ser  Phe Thr Thr Glu Asn  Val Gly Gln Arg Pro  Val Ala Tyr 
    1190                 1195                 1200             


Ile Tyr  Thr Asp Gln Asn Gly  Gln Lys Val Arg Gly  Thr Leu Asn 
    1205                 1210                 1215             


Val Val  Leu Asp Thr Val Ala  Pro Thr Leu Asn Val  Asp Gln Val 
    1220                 1225                 1230             


Asn Gly  Asn Glu Leu Glu Val  Lys Thr Asn Asn Pro  Leu Phe Lys 
    1235                 1240                 1245             


Leu Ser  Gly Val Val Asn Asp  Asn Leu Asp Gly Tyr  Arg Leu Tyr 
    1250                 1255                 1260             


Val Asn  Gly Asn Asn Ile Tyr  Arg Glu Phe Leu Asn  Ser Gly Tyr 
    1265                 1270                 1275             


Asn Lys  Leu Ala Gly Leu Asn  Thr Asp Gly Thr Asp  Val Asn Pro 
    1280                 1285                 1290             


Tyr Gly  Pro His Asn Phe Glu  Glu Ser Phe Asn Leu  Asn Asp Asp 
    1295                 1300                 1305             


Asn Asn  Gln Pro Thr Thr His  Val Phe Thr Ile Tyr  Val Val Asp 
    1310                 1315                 1320             


Gln Val  Gly Asn Lys Val Glu  Lys Lys Ile Ala Val  Asn Tyr Asp 
    1325                 1330                 1335             


Pro Asp  Tyr Val Ala 
    1340             


<210>  8
<211>  4026
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of fragment of PrtI

<400>  8
gcaataggag agacttctgt ccaaaatgtt aaagtttctg tggctaaaaa tgaaagtgat       60

tcacaaaaat ttaataatag tcagaacttg gaacaaaaaa ctccgcaagc agcagctgct      120

aatcaaaatg ggtcacaagt acaaaatgac catactgaaa ctcaattaca aaaccaacaa      180

actactcaat ctcaggtaac tcaagctcac acagaagaaa ataatgcttc atcaattcct      240

gaaccagcta atcaggccga tcatgtaaaa ggaaatgttc aatctgcatg ggaccagggt      300

tataaaggtc aaaatacggt tgtagccgta attgattctg gggctgatac cagtcataaa      360

gatttccaaa caatgccatc taatccaaaa cttaagcaag aagatgttca aagtaagatt      420

gatcagcaag gatatggaaa atatgttaat gaaaaatttc catatgttta taattatgcc      480

gatagggaca atgattatat taaatcggat gataataatc aaaatgatag tcctcatggg      540

caacatgttt ctggaattat tgcggcagat gggcaccctg agggtgatca acaatatgtt      600

gtcggagttg ctccagaagc tcagcttatg caacttagag tatttgggca attttctgat      660

gaaaaaacag atgatgtagc aagagctatc tatgatgcaa ctaacttagg tgccgatgtt      720

atccaaatgt ccttaggaca gggtgtggca gatcaacagt taactaatat tgaacaaaaa      780

gcagttcaat atgcgattga ccatggtgta tttgtttcaa tttctgcttc taataatgga      840

aattctgctt cagtagataa tccaagtaaa gttaccgcaa aaggttatgg gtccggatca      900

gaagctggaa attatgaacc tttgaattct ggaacggtcg ccaaccccgg tgcttctaag      960

aatgccttaa ctgttgctgc ggaaacttct ggaactggca aagatagtga catggcttca     1020

ttttcatcat ggggaccatt atctgatttt agtttaaagc cagatctttc agctcctggt     1080

tatcaggtgg tttcaactgt taatgataat caatatcaaa caatgagtgg aacttcaatg     1140

gctggtccat ttgcagctgg cagtgctgct ttagtaatcc aacggctaaa gcaaactaat     1200

ccagagttaa aaggagcaga acttgttgct gcaactaaag cattattgat gaatagcgct     1260

aaagtgcaaa cgcaaaatgg atacaccacg cctgtttctc caagaagaca aggtgcaggt     1320

caaattgatg taggagctgc tacggccaat ccagtttatg taactgctgc tgatggaacg     1380

agctccttat ctttacgtca agttgatgaa aaaactactt ttactcttac ttttcataat     1440

ttaacagatc aagaacaaag ctacagcttt aatgatttgg ggggaggtta tactgaacaa     1500

cgtgatcccg atagtggggt ctttcatgag gttcaattag caggagctca tgtgaatggt     1560

gtaggcaatt ttactctagc accaaaagag gttaaagacc ttcaatatac attagattta     1620

caggggttaa ataaaaatca gccagtagaa ggatggcttc attttactaa tgataaagat     1680

aaatcgactg tggtagtgcc atatttagca tattatggtg atttgactag tgaaaatgtc     1740

ttcgatcaaa atgcaaatga agaaaagcca gatattcaag gtaatcgttt cgttaatgaa     1800

aacaattatc cacttggagt aactgatcaa gaatctttaa aacaattagt aaatgttgac     1860

agtgattaca attggcaaga agttgctaaa ctttacgaaa gtggaaaagt tgctttttca     1920

ccaaatgatg atcatcaaag tgaccttatc aagccatatg cttatttaaa gcaaaatgta     1980

aaagacttaa aggttgaaat tttagacgct aagggtaacg tagtgcgcgt agtatctgat     2040

gttcaagggg ttgataagtc ttacgatgaa agtggagtaa ctaaagatgc tagtctttca     2100

gtctccatga gagacaatcc cgatgctttt gaatgggacg gtaaagttta cgatactaaa     2160

actggtcaaa tggtaacggc gcccgatgga caatatactt atcgctttgt tgctactctc     2220

tggaatgaag gaccaaatca aaaacagact gcagattttc cagttgtagt agatacacaa     2280

gctcctagtt taagcgttaa atatgattcg gctactcata ctttgtccgg taactatgaa     2340

gataagggtg caggttttac ggattattct tatgttactg tccaagtaaa tgataaagtc     2400

tttggttaca agttgaatga gggcgaatca ggttttgaca acagtgaaaa aacaaaaggt     2460

catttcaatt ttactttaag ttcagatgct ttggatgctt taagtggtag tttgaataaa     2520

gtttctgtaa ctttaagtga tgtagctaac aacacgacag ttaaaactgt tgatgttcct     2580

gctgttaaag atcaaccagc agtttctgtg tggaatgcaa ccgaaggggt agaatttaat     2640

aaaaattcta aagactacaa taaagaaaat gatacttaca ctttatatgg ttcagcggcc     2700

caagatttct atttaaatgg tgccttagtg caagtacgag atggcaaata cgaggttcca     2760

gtaaaaacga ctacccaaga tttggtattt tctactgatc aagcaggtaa aaatgtttta     2820

aagtctttca ctacttttac ccctaaggca ttctttaatt ggcaaaatgt cgatggcttt     2880

gacgggaatt ttggagtaaa tatctattct gtgaagacta atgatccaaa taatgcagtt     2940

gtgcaagcag cagttcctct aggtaaaaat gtcaaagcct atgctcaaga ctatttcact     3000

ggtgaagtat ataaaggcca agtagaaaat ggagtagcta ctttccatgt gcatacttct     3060

attaatcaag gcgaagacgg tatatttaaa cgtgcgcttt taacagggtg gagtgaagtg     3120

gacggtccgg catataatga taaacaagtt accagtaaag ctggtgtagc tagttcaaat     3180

catttaggtg tttattacac cactgataag gttaatcgaa aggtttatac tgatcgcgct     3240

gatttaggtg tagatgttca agatgaagca gctgacttaa gttcatttgg cccaaccgca     3300

tacccaggac atgctctagc agatttaact actcgaacgg atcctaatcc agcaattcat     3360

tttgattatt tgaatgataa tgacactact agatttggac aaaatgcagt gactgatgga     3420

tattatgatt ccgtaactaa aaagtttact gttacaggac atgtcgatcc agaagttaaa     3480

tcgcttactg tcttaggaga tagttctgat gaaaatgctc ctcaaaatca agtcaagttg     3540

ggcaaagatg gcaagttcag ttttagtttc actactgaaa atgtaggcca acgtcccgta     3600

gcttatattt atactgatca aaatggtcaa aaagttcgcg gtaccctaaa tgttgtctta     3660

gatacagttg cgccaacctt aaatgtagat caagtaaatg gtaacgaact tgaagtcaaa     3720

actaacaatc ctcttttcaa actttcagga gtagttaatg ataatttaga tggctataga     3780

ctttatgtaa atggcaataa tatttatcga gaattcttaa attctggcta caataaatta     3840

gcaggtttaa atactgatgg gacagatgta aacccatatg gtccgcataa ctttgaagaa     3900

agtttcaatt taaatgatga caacaatcaa ccaactactc atgtctttac gatttacgta     3960

gttgaccaag ttggtaataa agtagaaaag aagatcgctg ttaattatga tccagactat     4020

gtggct                                                                4026


<210>  9
<211>  1380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of PrtI from Lactobacillus intestinalis DSM6629


<220>
<221>  misc_feature
<222>  (204)..(204)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Met Arg Lys Lys Trp Val Ala Thr Ala Ile Ile Ala Leu Ala Ser Gly 
1               5                   10                  15      


Ser Thr Val Phe Leu Ser Gln Thr Ser Ser Val Glu Ala Ala Ile Gly 
            20                  25                  30          


Glu Thr Ser Val Gln Asn Val Lys Val Ser Val Ala Lys Asn Glu Ser 
        35                  40                  45              


Asp Ser Gln Lys Phe Asn Asn Ser Gln Asn Leu Glu Gln Lys Thr Pro 
    50                  55                  60                  


Gln Ala Ala Ala Ala Asn Gln Asn Gly Ser Gln Val Gln Asn Asp His 
65                  70                  75                  80  


Thr Glu Thr Gln Leu Gln Asn Gln Gln Thr Thr Gln Ser Gln Val Thr 
                85                  90                  95      


Gln Ala His Thr Glu Glu Asn Asn Ala Ser Ser Ile Pro Glu Pro Ala 
            100                 105                 110         


Asn Gln Ala Asp His Val Lys Gly Asn Val Gln Ser Ala Trp Asp Gln 
        115                 120                 125             


Gly Tyr Lys Gly Gln Asn Thr Val Val Ala Val Ile Asp Ser Gly Ala 
    130                 135                 140                 


Asp Thr Ser His Lys Asp Phe Gln Thr Met Pro Ser Asn Pro Lys Leu 
145                 150                 155                 160 


Lys Gln Glu Asp Val Gln Ser Lys Ile Asp Gln Gln Gly Tyr Gly Lys 
                165                 170                 175     


Tyr Val Asn Glu Lys Phe Pro Tyr Val Tyr Asn Tyr Ala Asp Arg Asp 
            180                 185                 190         


Asn Asp Tyr Ile Lys Ser Asp Asp Asn Asn Gln Xaa Asn Asp Ser Pro 
        195                 200                 205             


His Gly Gln His Val Ser Gly Ile Ile Ala Ala Asp Gly His Pro Glu 
    210                 215                 220                 


Gly Asp Gln Gln Tyr Val Val Gly Val Ala Pro Glu Ala Gln Leu Met 
225                 230                 235                 240 


Gln Leu Arg Val Phe Gly Gln Phe Ser Asp Glu Lys Thr Asp Asp Val 
                245                 250                 255     


Ala Arg Ala Ile Tyr Asp Ala Thr Asn Leu Gly Ala Asp Val Ile Gln 
            260                 265                 270         


Met Ser Leu Gly Gln Gly Val Ala Asp Gln Gln Leu Thr Asn Ile Glu 
        275                 280                 285             


Gln Lys Ala Val Gln Tyr Ala Ile Asp His Gly Val Phe Val Ser Ile 
    290                 295                 300                 


Ser Ala Ser Asn Asn Gly Asn Ser Ala Ser Val Asp Asn Pro Ser Lys 
305                 310                 315                 320 


Val Thr Ala Lys Gly Tyr Gly Ser Gly Ser Glu Ala Gly Asn Tyr Glu 
                325                 330                 335     


Pro Leu Asn Ser Gly Thr Val Ala Asn Pro Gly Ala Ser Lys Asn Ala 
            340                 345                 350         


Leu Thr Val Ala Ala Glu Thr Ser Gly Thr Gly Lys Asp Ser Asp Met 
        355                 360                 365             


Ala Ser Phe Ser Ser Trp Gly Pro Leu Ser Asp Phe Ser Leu Lys Pro 
    370                 375                 380                 


Asp Leu Ser Ala Pro Gly Tyr Gln Val Val Ser Thr Val Asn Asp Asn 
385                 390                 395                 400 


Gln Tyr Gln Thr Met Ser Gly Thr Ser Met Ala Gly Pro Phe Ala Ala 
                405                 410                 415     


Gly Ser Ala Ala Leu Val Ile Gln Arg Leu Lys Gln Thr Asn Pro Glu 
            420                 425                 430         


Leu Lys Gly Ala Glu Leu Val Ala Ala Thr Lys Ala Leu Leu Met Asn 
        435                 440                 445             


Ser Ala Lys Val Gln Thr Gln Asn Gly Tyr Thr Thr Pro Val Ser Pro 
    450                 455                 460                 


Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Gly Ala Ala Thr Ala Asn 
465                 470                 475                 480 


Pro Val Tyr Val Thr Ala Ala Asp Gly Thr Ser Ser Leu Ser Leu Arg 
                485                 490                 495     


Gln Val Asp Glu Lys Thr Thr Phe Thr Leu Thr Phe His Asn Leu Thr 
            500                 505                 510         


Asp Gln Glu Gln Ser Tyr Ser Phe Asn Asp Leu Gly Gly Gly Tyr Thr 
        515                 520                 525             


Glu Gln Arg Asp Pro Asp Ser Gly Val Phe His Glu Val Gln Leu Ala 
    530                 535                 540                 


Gly Ala His Val Asn Gly Val Gly Asn Phe Thr Leu Ala Pro Lys Glu 
545                 550                 555                 560 


Val Lys Asp Leu Gln Tyr Thr Leu Asp Leu Gln Gly Leu Asn Lys Asn 
                565                 570                 575     


Gln Pro Val Glu Gly Trp Leu His Phe Thr Asn Asp Lys Asp Lys Ser 
            580                 585                 590         


Thr Val Val Val Pro Tyr Leu Ala Tyr Tyr Gly Asp Leu Thr Ser Glu 
        595                 600                 605             


Asn Val Phe Asp Gln Asn Ala Asn Glu Glu Lys Pro Asp Ile Gln Gly 
    610                 615                 620                 


Asn Arg Phe Val Asn Glu Asn Asn Tyr Pro Leu Gly Val Thr Asp Gln 
625                 630                 635                 640 


Glu Ser Leu Lys Gln Leu Val Asn Val Asp Ser Asp Tyr Asn Trp Gln 
                645                 650                 655     


Glu Val Ala Lys Leu Tyr Glu Ser Gly Lys Val Ala Phe Ser Pro Asn 
            660                 665                 670         


Asp Asp His Gln Ser Asp Leu Ile Lys Pro Tyr Ala Tyr Leu Lys Gln 
        675                 680                 685             


Asn Val Lys Asp Leu Lys Val Glu Ile Leu Asp Ala Lys Gly Asn Val 
    690                 695                 700                 


Val Arg Val Val Ser Asp Val Gln Gly Val Asp Lys Ser Tyr Asp Glu 
705                 710                 715                 720 


Ser Gly Val Thr Lys Asp Ala Ser Leu Ser Val Ser Met Arg Asp Asn 
                725                 730                 735     


Pro Asp Ala Phe Glu Trp Asp Gly Lys Val Tyr Asp Thr Lys Thr Gly 
            740                 745                 750         


Gln Met Val Thr Ala Pro Asp Gly Gln Tyr Thr Tyr Arg Phe Val Ala 
        755                 760                 765             


Thr Leu Trp Asn Glu Gly Pro Asn Gln Lys Gln Thr Ala Asp Phe Pro 
    770                 775                 780                 


Val Val Val Asp Thr Gln Ala Pro Ser Leu Ser Val Lys Tyr Asp Ser 
785                 790                 795                 800 


Ala Thr His Thr Leu Ser Gly Asn Tyr Glu Asp Lys Gly Ala Gly Phe 
                805                 810                 815     


Thr Asp Tyr Ser Tyr Val Thr Val Gln Val Asn Asp Lys Val Phe Gly 
            820                 825                 830         


Tyr Lys Leu Asn Glu Gly Glu Ser Gly Phe Asp Asn Ser Glu Lys Thr 
        835                 840                 845             


Lys Gly His Phe Asn Phe Thr Leu Ser Ser Asp Ala Leu Asp Ala Leu 
    850                 855                 860                 


Ser Gly Ser Leu Asn Lys Val Ser Val Thr Leu Ser Asp Val Ala Asn 
865                 870                 875                 880 


Asn Thr Thr Val Lys Thr Val Asp Val Pro Ala Val Lys Asp Gln Pro 
                885                 890                 895     


Ala Val Ser Val Trp Asn Ala Thr Glu Gly Val Glu Phe Asn Lys Asn 
            900                 905                 910         


Ser Lys Asp Tyr Asn Lys Glu Asn Asp Thr Tyr Thr Leu Tyr Gly Ser 
        915                 920                 925             


Ala Ala Gln Asp Phe Tyr Leu Asn Gly Ala Leu Val Gln Val Arg Asp 
    930                 935                 940                 


Gly Lys Tyr Glu Val Pro Val Lys Thr Thr Thr Gln Asp Leu Val Phe 
945                 950                 955                 960 


Ser Thr Asp Gln Ala Gly Lys Asn Val Leu Lys Ser Phe Thr Thr Phe 
                965                 970                 975     


Thr Pro Lys Ala Phe Phe Asn Trp Gln Asn Val Asp Gly Phe Asp Gly 
            980                 985                 990         


Asn Phe Gly Val Asn Ile Tyr Ser  Val Lys Thr Asn Asp  Pro Asn Asn 
        995                 1000                 1005             


Ala Val  Val Gln Ala Ala Val  Pro Leu Gly Lys Asn  Val Lys Ala 
    1010                 1015                 1020             


Tyr Ala  Gln Asp Tyr Phe Thr  Gly Glu Val Tyr Lys  Gly Gln Val 
    1025                 1030                 1035             


Glu Asn  Gly Val Ala Thr Phe  His Val His Thr Ser  Ile Asn Gln 
    1040                 1045                 1050             


Gly Glu  Asp Gly Ile Phe Lys  Arg Ala Leu Leu Thr  Gly Trp Ser 
    1055                 1060                 1065             


Glu Val  Asp Gly Pro Ala Tyr  Asn Asp Lys Gln Val  Thr Ser Lys 
    1070                 1075                 1080             


Ala Gly  Val Ala Ser Ser Asn  His Leu Gly Val Tyr  Tyr Thr Thr 
    1085                 1090                 1095             


Asp Lys  Val Asn Arg Lys Val  Tyr Thr Asp Arg Ala  Asp Leu Gly 
    1100                 1105                 1110             


Val Asp  Val Gln Asp Glu Ala  Ala Asp Leu Ser Ser  Phe Gly Pro 
    1115                 1120                 1125             


Thr Ala  Tyr Pro Gly His Ala  Leu Ala Asp Leu Thr  Thr Arg Thr 
    1130                 1135                 1140             


Asp Pro  Asn Pro Ala Ile His  Phe Asp Tyr Leu Asn  Asp Asn Asp 
    1145                 1150                 1155             


Thr Thr  Arg Phe Gly Gln Asn  Ala Val Thr Asp Gly  Tyr Tyr Asp 
    1160                 1165                 1170             


Ser Val  Thr Lys Lys Phe Thr  Val Thr Gly His Val  Asp Pro Glu 
    1175                 1180                 1185             


Val Lys  Ser Leu Thr Val Leu  Gly Asp Ser Ser Asp  Glu Asn Ala 
    1190                 1195                 1200             


Pro Gln  Asn Gln Val Lys Leu  Gly Lys Asp Gly Lys  Phe Ser Phe 
    1205                 1210                 1215             


Ser Phe  Thr Thr Glu Asn Val  Gly Gln Arg Pro Val  Ala Tyr Ile 
    1220                 1225                 1230             


Tyr Thr  Asp Gln Asn Gly Gln  Lys Val Arg Gly Thr  Leu Asn Val 
    1235                 1240                 1245             


Val Leu  Asp Thr Val Ala Pro  Thr Leu Asn Val Asp  Gln Val Asn 
    1250                 1255                 1260             


Gly Asn  Glu Leu Glu Val Lys  Thr Asn Asn Pro Leu  Phe Lys Leu 
    1265                 1270                 1275             


Ser Gly  Val Val Asn Asp Asn  Leu Asp Gly Tyr Arg  Leu Tyr Val 
    1280                 1285                 1290             


Asn Gly  Asn Asn Ile Tyr Arg  Glu Phe Leu Asn Ser  Gly Tyr Asn 
    1295                 1300                 1305             


Lys Leu  Ala Gly Leu Asn Thr  Asp Gly Thr Asp Val  Asn Pro Tyr 
    1310                 1315                 1320             


Gly Pro  His Asn Phe Glu Glu  Ser Phe Asn Leu Asn  Asp Asp Asn 
    1325                 1330                 1335             


Asn Gln  Pro Thr Thr His Val  Phe Thr Ile Tyr Val  Val Asp Gln 
    1340                 1345                 1350             


Val Gly  Asn Lys Val Glu Lys  Lys Ile Ala Val Asn  Tyr Asp Pro 
    1355                 1360                 1365             


Asp Tyr  Val Ala Pro Arg His  His His His His His  
    1370                 1375                 1380 


<210>  10
<211>  4137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neicleic acid encoding fragment of PrtI

<400>  10
atgcgaaaga aatgggtggc tacagctatt attgctttag catctggttc gactgtcttt       60

ttgagtcaga catcttctgt tgaagcagca ataggagaga cttctgtcca aaatgttaaa      120

gtttctgtgg ctaaaaatga aagtgattca caaaaattta ataatagtca gaacttggaa      180

caaaaaactc cgcaagcagc agctgctaat caaaatgggt cacaagtaca aaatgaccat      240

actgaaactc aattacaaaa ccaacaaact actcaatctc aggtaactca agctcacaca      300

gaagaaaata atgcttcatc aattcctgaa ccagctaatc aggccgatca tgtaaaagga      360

aatgttcaat ctgcatggga ccagggttat aaaggtcaaa atacggttgt agccgtaatt      420

gattctgggg ctgataccag tcataaagat ttccaaacaa tgccatctaa tccaaaactt      480

aagcaagaag atgttcaaag taagattgat cagcaaggat atggaaaata tgttaatgaa      540

aaatttccat atgtttataa ttatgccgat agggacaatg attatattaa atcggatgat      600

aataatcaaa atgatagtcc tcatgggcaa catgtttctg gaattattgc ggcagatggg      660

caccctgagg gtgatcaaca atatgttgtc ggagttgctc cagaagctca gcttatgcaa      720

cttagagtat ttgggcaatt ttctgatgaa aaaacagatg atgtagcaag agctatctat      780

gatgcaacta acttaggtgc cgatgttatc caaatgtcct taggacaggg tgtggcagat      840

caacagttaa ctaatattga acaaaaagca gttcaatatg cgattgacca tggtgtattt      900

gtttcaattt ctgcttctaa taatggaaat tctgcttcag tagataatcc aagtaaagtt      960

accgcaaaag gttatgggtc cggatcagaa gctggaaatt atgaaccttt gaattctgga     1020

acggtcgcca accccggtgc ttctaagaat gccttaactg ttgctgcgga aacttctgga     1080

actggcaaag atagtgacat ggcttcattt tcatcatggg gaccattatc tgattttagt     1140

ttaaagccag atctttcagc tcctggttat caggtggttt caactgttaa tgataatcaa     1200

tatcaaacaa tgagtggaac ttcaatggct ggtccatttg cagctggcag tgctgcttta     1260

gtaatccaac ggctaaagca aactaatcca gagttaaaag gagcagaact tgttgctgca     1320

actaaagcat tattgatgaa tagcgctaaa gtgcaaacgc aaaatggata caccacgcct     1380

gtttctccaa gaagacaagg tgcaggtcaa attgatgtag gagctgctac ggccaatcca     1440

gtttatgtaa ctgctgctga tggaacgagc tccttatctt tacgtcaagt tgatgaaaaa     1500

actactttta ctcttacttt tcataattta acagatcaag aacaaagcta cagctttaat     1560

gatttggggg gaggttatac tgaacaacgt gatcccgata gtggggtctt tcatgaggtt     1620

caattagcag gagctcatgt gaatggtgta ggcaatttta ctctagcacc aaaagaggtt     1680

aaagaccttc aatatacatt agatttacag gggttaaata aaaatcagcc agtagaagga     1740

tggcttcatt ttactaatga taaagataaa tcgactgtgg tagtgccata tttagcatat     1800

tatggtgatt tgactagtga aaatgtcttc gatcaaaatg caaatgaaga aaagccagat     1860

attcaaggta atcgtttcgt taatgaaaac aattatccac ttggagtaac tgatcaagaa     1920

tctttaaaac aattagtaaa tgttgacagt gattacaatt ggcaagaagt tgctaaactt     1980

tacgaaagtg gaaaagttgc tttttcacca aatgatgatc atcaaagtga ccttatcaag     2040

ccatatgctt atttaaagca aaatgtaaaa gacttaaagg ttgaaatttt agacgctaag     2100

ggtaacgtag tgcgcgtagt atctgatgtt caaggggttg ataagtctta cgatgaaagt     2160

ggagtaacta aagatgctag tctttcagtc tccatgagag acaatcccga tgcttttgaa     2220

tgggacggta aagtttacga tactaaaact ggtcaaatgg taacggcgcc cgatggacaa     2280

tatacttatc gctttgttgc tactctctgg aatgaaggac caaatcaaaa acagactgca     2340

gattttccag ttgtagtaga tacacaagct cctagtttaa gcgttaaata tgattcggct     2400

actcatactt tgtccggtaa ctatgaagat aagggtgcag gttttacgga ttattcttat     2460

gttactgtcc aagtaaatga taaagtcttt ggttacaagt tgaatgaggg cgaatcaggt     2520

tttgacaaca gtgaaaaaac aaaaggtcat ttcaatttta ctttaagttc agatgctttg     2580

gatgctttaa gtggtagttt gaataaagtt tctgtaactt taagtgatgt agctaacaac     2640

acgacagtta aaactgttga tgttcctgct gttaaagatc aaccagcagt ttctgtgtgg     2700

aatgcaaccg aaggggtaga atttaataaa aattctaaag actacaataa agaaaatgat     2760

acttacactt tatatggttc agcggcccaa gatttctatt taaatggtgc cttagtgcaa     2820

gtacgagatg gcaaatacga ggttccagta aaaacgacta cccaagattt ggtattttct     2880

actgatcaag caggtaaaaa tgttttaaag tctttcacta cttttacccc taaggcattc     2940

tttaattggc aaaatgtcga tggctttgac gggaattttg gagtaaatat ctattctgtg     3000

aagactaatg atccaaataa tgcagttgtg caagcagcag ttcctctagg taaaaatgtc     3060

aaagcctatg ctcaagacta tttcactggt gaagtatata aaggccaagt agaaaatgga     3120

gtagctactt tccatgtgca tacttctatt aatcaaggcg aagacggtat atttaaacgt     3180

gcgcttttaa cagggtggag tgaagtggac ggtccggcat ataatgataa acaagttacc     3240

agtaaagctg gtgtagctag ttcaaatcat ttaggtgttt attacaccac tgataaggtt     3300

aatcgaaagg tttatactga tcgcgctgat ttaggtgtag atgttcaaga tgaagcagct     3360

gacttaagtt catttggccc aaccgcatac ccaggacatg ctctagcaga tttaactact     3420

cgaacggatc ctaatccagc aattcatttt gattatttga atgataatga cactactaga     3480

tttggacaaa atgcagtgac tgatggatat tatgattccg taactaaaaa gtttactgtt     3540

acaggacatg tcgatccaga agttaaatcg cttactgtct taggagatag ttctgatgaa     3600

aatgctcctc aaaatcaagt caagttgggc aaagatggca agttcagttt tagtttcact     3660

actgaaaatg taggccaacg tcccgtagct tatatttata ctgatcaaaa tggtcaaaaa     3720

gttcgcggta ccctaaatgt tgtcttagat acagttgcgc caaccttaaa tgtagatcaa     3780

gtaaatggta acgaacttga agtcaaaact aacaatcctc ttttcaaact ttcaggagta     3840

gttaatgata atttagatgg ctatagactt tatgtaaatg gcaataatat ttatcgagaa     3900

ttcttaaatt ctggctacaa taaattagca ggtttaaata ctgatgggac agatgtaaac     3960

ccatatggtc cgcataactt tgaagaaagt ttcaatttaa atgatgacaa caatcaacca     4020

actactcatg tctttacgat ttacgtagtt gaccaagttg gtaataaagt agaaaagaag     4080

atcgctgtta attatgatcc agactatgtg gctcctaggc atcatcacca ccaccat        4137


<210>  11
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for PrtV

<400>  11
cagcagggat ccgataccgt taatggtagt gaaagt                                 36


<210>  12
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for PrtV

<400>  12
cagcagctcg agctatactt ttactggttc tgcagctttt ttgccc                      46


<210>  13
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for PrtV

<400>  13
cagcagctcg agctaatagt gaacatagaa cttcctagtt ac                          42


<210>  14
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for PrtV

<400>  14
cagcagctcg agctaattat ttacttgcca tgcaaaaaca g                           41


<210>  15
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forwward primer for PrtV

<400>  15
cagcagggat ccactgttaa ggaaaacttt ggtattg                                37


<210>  16
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for PrtI

<400>  16
cagcaggaat tccgcaatag gagagacttc tgtc                                   34


<210>  17
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for PrtI

<400>  17
cagcagctcg agttaagcca catagtctgg atcataatta ac                          42


<210>  18
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for PrtI

<400>  18
cttcatcaat tcctgaacca gaaaacctgt attttcaggg cgctaatcag gccgatcatg       60


<210>  19
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for PrtI

<400>  19
cagcaggcat gctaactaag gaggtcatga tatgcgaaag aaatgggtgg ctacagc          57


<210>  20
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for PrtI

<400>  20
cagcagctcg agtctagatt aatggtggtg gtgatgatgc ctaggagcca catagtctgg       60

atcataatta acagcg                                                       76


<210>  21
<211>  1571
<212>  PRT
<213>  Lactobacillus crispatus

<400>  21

Met Ser Asn Leu Thr Asn Pro Asn Asp His Lys Asp Leu Ser Phe Leu 
1               5                   10                  15      


Phe Lys Ser Val Asp Arg Leu Ala Ala Leu Glu Thr Gln Lys Lys Ala 
            20                  25                  30          


Asp Thr Ile Ile Ser Val Arg Lys Lys Trp Val Ala Ala Ala Met Ile 
        35                  40                  45              


Ala Leu Ala Ser Gly Ser Thr Val Leu Leu Thr Ser Asn Thr Ala Asn 
    50                  55                  60                  


Ala Ala Thr Ser Asp Val Asn Ser Glu Val Gln Val Thr Ala Gln Asn 
65                  70                  75                  80  


Gln Asn Thr Thr Glu Asn Lys Met Gln Ala Gly Asp Thr Ala Asn Ser 
                85                  90                  95      


His Asp Thr Glu Gln Asn Val Thr Val Gln Ala Asn Ser Ser Gln Gln 
            100                 105                 110         


Ser Asn Gln Glu Ala Asn Thr Ala Asp Gln Asn Asn Thr Pro Glu Asn 
        115                 120                 125             


Asp Asn Gln Val Gln Thr Pro Thr Asn Gln Ala Asp His Val Lys Gly 
    130                 135                 140                 


Asn Val Gln Ser Ala Trp Asp Gln Gly Tyr Lys Gly Gln Gly Thr Val 
145                 150                 155                 160 


Val Ala Val Ile Asp Ser Gly Ala Asp Pro Ser His Lys Asp Phe Gln 
                165                 170                 175     


Thr Met Pro Glu Asn Pro Lys Leu Ser Lys Asp Asp Ile Gln Lys Lys 
            180                 185                 190         


Ile Glu Gln Gln Gly Tyr Gly Lys Tyr Val Asn Glu Lys Phe Pro Tyr 
        195                 200                 205             


Val Tyr Asn Tyr Ala Asp Arg Asp Asn Asp Tyr Ile Thr Ser Asp Asp 
    210                 215                 220                 


Thr Asn Ser Asn Asp Ser Pro His Gly Gln His Val Ser Gly Ile Ile 
225                 230                 235                 240 


Ala Ala Asp Gly Lys Pro Asp Gly Asn Lys Glu Tyr Val Val Gly Val 
                245                 250                 255     


Ala Pro Glu Ala Gln Leu Met Gln Leu Arg Val Phe Gly Gln Phe Ser 
            260                 265                 270         


Asp Glu Lys Thr Asp Asp Val Ala Lys Ala Ile Tyr Asp Ala Thr Asn 
        275                 280                 285             


Leu Gly Ala Asp Val Ile Gln Met Ser Leu Gly Gln Gly Val Ala Asp 
    290                 295                 300                 


Gln Gln Leu Thr Asn Ile Glu Gln Lys Ala Val Gln Tyr Ala Ile Asp 
305                 310                 315                 320 


His Gly Val Phe Val Ser Ile Ser Ala Ser Asn Asn Gly His Ser Gly 
                325                 330                 335     


Ser Val Asp Asn Thr Ser Asn Val Thr Ser Val Glu Ser Tyr Glu Ser 
            340                 345                 350         


Gly Ser Ala Asp Gly Asn Tyr Glu Pro Leu Asn Ser Ser Thr Val Ala 
        355                 360                 365             


Asn Pro Gly Ala Ser Lys Asn Ala Leu Thr Val Ala Ala Glu Thr Ser 
    370                 375                 380                 


Ala Thr Gly Lys Asp Ser Asp Met Ala Gly Phe Ser Ser Trp Gly Pro 
385                 390                 395                 400 


Val Gln Asp Phe Thr Leu Lys Pro Asp Leu Ala Ala Pro Gly Tyr Gln 
                405                 410                 415     


Val Val Ser Thr Val Asn Asn Asn Asn Tyr Gln Thr Met Ser Gly Thr 
            420                 425                 430         


Ser Met Ala Gly Pro Phe Ala Ala Ala Ser Ala Ala Leu Val Met Gln 
        435                 440                 445             


Arg Leu Lys Lys Thr Asn Pro Glu Leu Lys Gly Ala Gln Leu Val Ala 
    450                 455                 460                 


Ala Thr Lys Ala Leu Leu Met Asn Ser Ala Lys Pro Gln Thr Gln Asn 
465                 470                 475                 480 


Gly Tyr Thr Thr Pro Val Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile 
                485                 490                 495     


Asp Val Gly Ala Ala Thr Ser Asn Pro Val Tyr Val Ile Ala Asp Asp 
            500                 505                 510         


Gly Thr Ser Ser Val Ser Leu His Gln Val Lys Glu Asn Thr Pro Phe 
        515                 520                 525             


Thr Leu Thr Phe His Asn Leu Thr Asp Gln Glu Gln Val Tyr Thr Phe 
    530                 535                 540                 


Asp Asp Phe Gly Gly Gly Tyr Thr Glu Gln Arg Asp Ser Asn Thr Gly 
545                 550                 555                 560 


Val Tyr His Asp Val Gln Leu Ala Gly Ala Arg Val Tyr Gly Glu Asn 
                565                 570                 575     


Ser Phe Ser Leu Ala Pro Lys Glu Thr Lys Gln Val Thr Tyr Ser Leu 
            580                 585                 590         


Asn Leu Asn Gly Leu Asn Asn Asn Gln Leu Val Glu Gly Phe Leu Arg 
        595                 600                 605             


Phe Thr Asn Thr Asn Asp Lys Ser Thr Val Ser Val Pro Tyr Leu Ala 
    610                 615                 620                 


Tyr Tyr Gly Asp Leu Thr Ser Glu Asn Val Phe Asp Gln Asn Ala Asn 
625                 630                 635                 640 


Glu Glu His Pro Asp Ile Gln Gly Asn Arg Phe Val Asn Glu Gln Ser 
                645                 650                 655     


Tyr Pro Arg Gly Val Ala Asp Gln Glu Ser Leu Lys Gln Leu Val Asn 
            660                 665                 670         


Val Glu Gly Asp Tyr Asn Trp Gln Glu Val Ala Lys Leu Tyr Glu Ser 
        675                 680                 685             


Gly Lys Val Ala Phe Ser Pro Asn Asn Asp Asn Lys Ser Asp Leu Leu 
    690                 695                 700                 


Lys Pro Tyr Thr Tyr Leu Lys Gln Asn Val Lys Asp Leu Lys Ala Val 
705                 710                 715                 720 


Val Leu Asp Ala Gln Gly Asn Val Val Arg Val Val Ala Asp Val Gln 
                725                 730                 735     


Gly Val Asp Lys Ser Tyr Asp Glu Asn Gly Val Thr Lys Asp Thr Ser 
            740                 745                 750         


Leu Ser Val Ser Met Arg Asp Asn Pro Asp Ala Phe Glu Trp Asp Gly 
        755                 760                 765             


Lys Val Tyr Asn Ser Lys Thr Gly Gln Met Glu Val Ala Lys Asp Gly 
    770                 775                 780                 


Asn Tyr Thr Tyr Arg Leu Val Ala Thr Leu Trp Asn Glu Gly Pro His 
785                 790                 795                 800 


Gln Val Gln Thr Ala Asp Phe Pro Val Val Ile Asp Thr Val Ala Pro 
                805                 810                 815     


Thr Leu Ser Asn Val Lys Tyr Asp Glu Ala Thr Asn Thr Leu Ser Gly 
            820                 825                 830         


Glu Tyr Gln Asp Thr Gly Ala Gly Phe Thr Asn Tyr Ser Tyr Ala Thr 
        835                 840                 845             


Val Thr Val Asn Asp Lys Val Phe Gly Tyr Lys Leu Ser Asp Gly Gln 
    850                 855                 860                 


Ser Ala Phe Asp Asn Ala Glu Lys Thr Lys Gly His Phe Ser Phe Thr 
865                 870                 875                 880 


Leu Asp Lys Asp Ala Val Ala Ala Leu Ser Gly Ala Lys Asn Lys Val 
                885                 890                 895     


Ser Val Val Leu Ser Asp Val Ala Asp Asn Pro Val Val Tyr Ser Val 
            900                 905                 910         


Asn Val Ala Gly Lys Asp Ile Asp Lys Pro Ala Val Ser Val Trp Asn 
        915                 920                 925             


Ala Thr Asn Gly Leu Ala Phe Asp Gln Ser Ser Thr Ser Tyr Asn Lys 
    930                 935                 940                 


Asp Thr Lys Thr Tyr Thr Leu Ile Gly Gly Ala Asn Gln Asp Phe Tyr 
945                 950                 955                 960 


Leu Asn Gly Lys Leu Val Gln Val Gln Asn Gly Gln Tyr Ser Val Pro 
                965                 970                 975     


Val Asp Val Asn Ser Thr Asn Leu Val Phe Ser Thr Asp Ala Ala Gly 
            980                 985                 990         


Lys Asn Val Leu Lys Asn Phe Ser  Thr Val Thr Pro Lys  Ala Phe Phe 
        995                 1000                 1005             


Asn Trp  Gln Val Thr Asp Thr  Phe Ala Gly Asn Phe  Gly Val Ser 
    1010                 1015                 1020             


Ile Asn  Ser Val Glu Thr Asn  Arg Lys Asp Asp Val  Val Val Gln 
    1025                 1030                 1035             


Ala Ala  Val Pro Lys Gly Glu  Asn Ile Gln Ala Phe  Ala Lys Asp 
    1040                 1045                 1050             


Tyr Phe  Thr Gly Glu Leu Tyr  Thr Gly Glu Val Asn  Asp Gly Val 
    1055                 1060                 1065             


Ala Thr  Phe His Val His Thr  Ser Ile Asn Gly Gly  Arg Arg Ala 
    1070                 1075                 1080             


Leu Leu  Thr Gly Trp Thr Val  Val Asn Gly Pro Ser  Tyr Asn Asp 
    1085                 1090                 1095             


Lys Gln  Glu Thr Ser Gln Arg  Gly Val Ala Ser Ser  Asn His Leu 
    1100                 1105                 1110             


Gly Val  Tyr Tyr Glu Val Asp  Ala Ala Asp Arg Pro  Val Tyr Thr 
    1115                 1120                 1125             


Asn Arg  Asn Gln Leu Gly Val  Glu Val Lys Asp Glu  Ala Ala Asn 
    1130                 1135                 1140             


Val Asp  Ala Phe Gly Pro Gly  Ala Tyr Pro Gly His  Ala Pro Ser 
    1145                 1150                 1155             


Asp Leu  Thr Thr Arg Thr Ala  Ser Asn Pro Asn Ile  His Phe Asp 
    1160                 1165                 1170             


Tyr Met  Asn Asp Asn Asp Thr  Thr Arg Phe Gly Gln  Asn Ala Val 
    1175                 1180                 1185             


Leu Lys  Gly Tyr Tyr Asp Pro  Thr Thr Met Lys Phe  Thr Val Thr 
    1190                 1195                 1200             


Gly Asn  Val Asp Asp Asn Val  Thr Ser Leu Thr Val  Leu Ser Asp 
    1205                 1210                 1215             


Ser Ser  Asn Glu Asn Asp Pro  Ala Asn Gln Val Lys  Leu Asp Gln 
    1220                 1225                 1230             


Asn Gly  Lys Phe Ser Phe Ala  Val Thr Ala Asn Ser  Thr Gly Gln 
    1235                 1240                 1245             


Arg Pro  Ile Ala Tyr Leu Tyr  Arg Thr Lys Asp Gly  Gln Thr Val 
    1250                 1255                 1260             


Arg Gly  Thr Leu Asn Leu Ile  Leu Asp Thr Val Lys  Pro Thr Leu 
    1265                 1270                 1275             


Glu Val  Asn Gln Val Asn Gly  Asn Glu Leu Glu Leu  Trp Thr Asn 
    1280                 1285                 1290             


Asn Pro  Lys Phe Val Leu Ser  Gly Lys Val Asn Asp  Asn Leu Asp 
    1295                 1300                 1305             


Gly Tyr  Arg Leu Tyr Val Asn  Gly Asn Asn Ile Tyr  Arg Glu Phe 
    1310                 1315                 1320             


Leu Asn  Ser Gly Tyr Asn Arg  Leu Glu Gly Leu Asn  Thr Asp Thr 
    1325                 1330                 1335             


Glu Leu  Thr Asn Pro Tyr Gly  Asp His Glu Phe Glu  Gln Val Glu 
    1340                 1345                 1350             


Asn Leu  Asn Asp Asn Asn Asp  Gln Pro Thr Thr His  Ile Phe Thr 
    1355                 1360                 1365             


Val Asn  Val Val Asp Gln Ala  Gly Asn Thr Val Thr  Lys Lys Leu 
    1370                 1375                 1380             


Thr Val  His Phe Asp Pro Asn  Tyr Val Val Pro Thr  Asp Asn Thr 
    1385                 1390                 1395             


Asp Val  Val Val Asp Thr Ser  Thr Ser Asp Thr Asp  Gly Val Thr 
    1400                 1405                 1410             


Glu Thr  Lys Pro Ile Asp Pro  Leu Val Gly Lys Ser  Phe Lys Leu 
    1415                 1420                 1425             


Leu His  Asn Ala Tyr Leu Tyr  Asp Gln Asn Gly Glu  Val Val Leu 
    1430                 1435                 1440             


Thr Asp  Val Glu Asn Ala Lys  Ser Leu Leu Lys Lys  Gly Gln Thr 
    1445                 1450                 1455             


Ile Val  Ala Leu Asp Asn Ala  Lys Val Thr Phe Ile  Asn Gly Val 
    1460                 1465                 1470             


Lys Phe  Tyr Arg Val Gly Asn  Asn Thr Phe Val Lys  Thr Ala Asn 
    1475                 1480                 1485             


Thr Val  Leu Gln Ala Pro Lys  Arg Leu Lys Leu Thr  His Asn Ala 
    1490                 1495                 1500             


Tyr Val  Tyr Asp Gln Lys Gly  Asn Val Val Lys Lys  His Gly Lys 
    1505                 1510                 1515             


Lys Val  Leu Leu Lys Lys Asn  Gln Trp Ile Ser Ala  Leu Asn Asn 
    1520                 1525                 1530             


Ala Asp  Lys Tyr Val Ile Lys  Gly Arg Leu Tyr Tyr  Lys Leu Ala 
    1535                 1540                 1545             


Asp Gly  Gln Phe Val Lys Val  Ala Asn Thr Val Thr  Lys Lys Ala 
    1550                 1555                 1560             


Lys Leu  Arg Lys Thr Val Val  Ser 
    1565                 1570     


<210>  22
<211>  1503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Lactobacillus crispatus protease

<400>  22

Asp Val Asn Ser Glu Val Gln Val Thr Ala Gln Asn Gln Asn Thr Thr 
1               5                   10                  15      


Glu Asn Lys Met Gln Ala Gly Asp Thr Ala Asn Ser His Asp Thr Glu 
            20                  25                  30          


Gln Asn Val Thr Val Gln Ala Asn Ser Ser Gln Gln Ser Asn Gln Glu 
        35                  40                  45              


Ala Asn Thr Ala Asp Gln Asn Asn Thr Pro Glu Asn Asp Asn Gln Val 
    50                  55                  60                  


Gln Thr Pro Thr Asn Gln Ala Asp His Val Lys Gly Asn Val Gln Ser 
65                  70                  75                  80  


Ala Trp Asp Gln Gly Tyr Lys Gly Gln Gly Thr Val Val Ala Val Ile 
                85                  90                  95      


Asp Ser Gly Ala Asp Pro Ser His Lys Asp Phe Gln Thr Met Pro Glu 
            100                 105                 110         


Asn Pro Lys Leu Ser Lys Asp Asp Ile Gln Lys Lys Ile Glu Gln Gln 
        115                 120                 125             


Gly Tyr Gly Lys Tyr Val Asn Glu Lys Phe Pro Tyr Val Tyr Asn Tyr 
    130                 135                 140                 


Ala Asp Arg Asp Asn Asp Tyr Ile Thr Ser Asp Asp Thr Asn Ser Asn 
145                 150                 155                 160 


Asp Ser Pro His Gly Gln His Val Ser Gly Ile Ile Ala Ala Asp Gly 
                165                 170                 175     


Lys Pro Asp Gly Asn Lys Glu Tyr Val Val Gly Val Ala Pro Glu Ala 
            180                 185                 190         


Gln Leu Met Gln Leu Arg Val Phe Gly Gln Phe Ser Asp Glu Lys Thr 
        195                 200                 205             


Asp Asp Val Ala Lys Ala Ile Tyr Asp Ala Thr Asn Leu Gly Ala Asp 
    210                 215                 220                 


Val Ile Gln Met Ser Leu Gly Gln Gly Val Ala Asp Gln Gln Leu Thr 
225                 230                 235                 240 


Asn Ile Glu Gln Lys Ala Val Gln Tyr Ala Ile Asp His Gly Val Phe 
                245                 250                 255     


Val Ser Ile Ser Ala Ser Asn Asn Gly His Ser Gly Ser Val Asp Asn 
            260                 265                 270         


Thr Ser Asn Val Thr Ser Val Glu Ser Tyr Glu Ser Gly Ser Ala Asp 
        275                 280                 285             


Gly Asn Tyr Glu Pro Leu Asn Ser Ser Thr Val Ala Asn Pro Gly Ala 
    290                 295                 300                 


Ser Lys Asn Ala Leu Thr Val Ala Ala Glu Thr Ser Ala Thr Gly Lys 
305                 310                 315                 320 


Asp Ser Asp Met Ala Gly Phe Ser Ser Trp Gly Pro Val Gln Asp Phe 
                325                 330                 335     


Thr Leu Lys Pro Asp Leu Ala Ala Pro Gly Tyr Gln Val Val Ser Thr 
            340                 345                 350         


Val Asn Asn Asn Asn Tyr Gln Thr Met Ser Gly Thr Ser Met Ala Gly 
        355                 360                 365             


Pro Phe Ala Ala Ala Ser Ala Ala Leu Val Met Gln Arg Leu Lys Lys 
    370                 375                 380                 


Thr Asn Pro Glu Leu Lys Gly Ala Gln Leu Val Ala Ala Thr Lys Ala 
385                 390                 395                 400 


Leu Leu Met Asn Ser Ala Lys Pro Gln Thr Gln Asn Gly Tyr Thr Thr 
                405                 410                 415     


Pro Val Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Gly Ala 
            420                 425                 430         


Ala Thr Ser Asn Pro Val Tyr Val Ile Ala Asp Asp Gly Thr Ser Ser 
        435                 440                 445             


Val Ser Leu His Gln Val Lys Glu Asn Thr Pro Phe Thr Leu Thr Phe 
    450                 455                 460                 


His Asn Leu Thr Asp Gln Glu Gln Val Tyr Thr Phe Asp Asp Phe Gly 
465                 470                 475                 480 


Gly Gly Tyr Thr Glu Gln Arg Asp Ser Asn Thr Gly Val Tyr His Asp 
                485                 490                 495     


Val Gln Leu Ala Gly Ala Arg Val Tyr Gly Glu Asn Ser Phe Ser Leu 
            500                 505                 510         


Ala Pro Lys Glu Thr Lys Gln Val Thr Tyr Ser Leu Asn Leu Asn Gly 
        515                 520                 525             


Leu Asn Asn Asn Gln Leu Val Glu Gly Phe Leu Arg Phe Thr Asn Thr 
    530                 535                 540                 


Asn Asp Lys Ser Thr Val Ser Val Pro Tyr Leu Ala Tyr Tyr Gly Asp 
545                 550                 555                 560 


Leu Thr Ser Glu Asn Val Phe Asp Gln Asn Ala Asn Glu Glu His Pro 
                565                 570                 575     


Asp Ile Gln Gly Asn Arg Phe Val Asn Glu Gln Ser Tyr Pro Arg Gly 
            580                 585                 590         


Val Ala Asp Gln Glu Ser Leu Lys Gln Leu Val Asn Val Glu Gly Asp 
        595                 600                 605             


Tyr Asn Trp Gln Glu Val Ala Lys Leu Tyr Glu Ser Gly Lys Val Ala 
    610                 615                 620                 


Phe Ser Pro Asn Asn Asp Asn Lys Ser Asp Leu Leu Lys Pro Tyr Thr 
625                 630                 635                 640 


Tyr Leu Lys Gln Asn Val Lys Asp Leu Lys Ala Val Val Leu Asp Ala 
                645                 650                 655     


Gln Gly Asn Val Val Arg Val Val Ala Asp Val Gln Gly Val Asp Lys 
            660                 665                 670         


Ser Tyr Asp Glu Asn Gly Val Thr Lys Asp Thr Ser Leu Ser Val Ser 
        675                 680                 685             


Met Arg Asp Asn Pro Asp Ala Phe Glu Trp Asp Gly Lys Val Tyr Asn 
    690                 695                 700                 


Ser Lys Thr Gly Gln Met Glu Val Ala Lys Asp Gly Asn Tyr Thr Tyr 
705                 710                 715                 720 


Arg Leu Val Ala Thr Leu Trp Asn Glu Gly Pro His Gln Val Gln Thr 
                725                 730                 735     


Ala Asp Phe Pro Val Val Ile Asp Thr Val Ala Pro Thr Leu Ser Asn 
            740                 745                 750         


Val Lys Tyr Asp Glu Ala Thr Asn Thr Leu Ser Gly Glu Tyr Gln Asp 
        755                 760                 765             


Thr Gly Ala Gly Phe Thr Asn Tyr Ser Tyr Ala Thr Val Thr Val Asn 
    770                 775                 780                 


Asp Lys Val Phe Gly Tyr Lys Leu Ser Asp Gly Gln Ser Ala Phe Asp 
785                 790                 795                 800 


Asn Ala Glu Lys Thr Lys Gly His Phe Ser Phe Thr Leu Asp Lys Asp 
                805                 810                 815     


Ala Val Ala Ala Leu Ser Gly Ala Lys Asn Lys Val Ser Val Val Leu 
            820                 825                 830         


Ser Asp Val Ala Asp Asn Pro Val Val Tyr Ser Val Asn Val Ala Gly 
        835                 840                 845             


Lys Asp Ile Asp Lys Pro Ala Val Ser Val Trp Asn Ala Thr Asn Gly 
    850                 855                 860                 


Leu Ala Phe Asp Gln Ser Ser Thr Ser Tyr Asn Lys Asp Thr Lys Thr 
865                 870                 875                 880 


Tyr Thr Leu Ile Gly Gly Ala Asn Gln Asp Phe Tyr Leu Asn Gly Lys 
                885                 890                 895     


Leu Val Gln Val Gln Asn Gly Gln Tyr Ser Val Pro Val Asp Val Asn 
            900                 905                 910         


Ser Thr Asn Leu Val Phe Ser Thr Asp Ala Ala Gly Lys Asn Val Leu 
        915                 920                 925             


Lys Asn Phe Ser Thr Val Thr Pro Lys Ala Phe Phe Asn Trp Gln Val 
    930                 935                 940                 


Thr Asp Thr Phe Ala Gly Asn Phe Gly Val Ser Ile Asn Ser Val Glu 
945                 950                 955                 960 


Thr Asn Arg Lys Asp Asp Val Val Val Gln Ala Ala Val Pro Lys Gly 
                965                 970                 975     


Glu Asn Ile Gln Ala Phe Ala Lys Asp Tyr Phe Thr Gly Glu Leu Tyr 
            980                 985                 990         


Thr Gly Glu Val Asn Asp Gly Val  Ala Thr Phe His Val  His Thr Ser 
        995                 1000                 1005             


Ile Asn  Gly Gly Arg Arg Ala  Leu Leu Thr Gly Trp  Thr Val Val 
    1010                 1015                 1020             


Asn Gly  Pro Ser Tyr Asn Asp  Lys Gln Glu Thr Ser  Gln Arg Gly 
    1025                 1030                 1035             


Val Ala  Ser Ser Asn His Leu  Gly Val Tyr Tyr Glu  Val Asp Ala 
    1040                 1045                 1050             


Ala Asp  Arg Pro Val Tyr Thr  Asn Arg Asn Gln Leu  Gly Val Glu 
    1055                 1060                 1065             


Val Lys  Asp Glu Ala Ala Asn  Val Asp Ala Phe Gly  Pro Gly Ala 
    1070                 1075                 1080             


Tyr Pro  Gly His Ala Pro Ser  Asp Leu Thr Thr Arg  Thr Ala Ser 
    1085                 1090                 1095             


Asn Pro  Asn Ile His Phe Asp  Tyr Met Asn Asp Asn  Asp Thr Thr 
    1100                 1105                 1110             


Arg Phe  Gly Gln Asn Ala Val  Leu Lys Gly Tyr Tyr  Asp Pro Thr 
    1115                 1120                 1125             


Thr Met  Lys Phe Thr Val Thr  Gly Asn Val Asp Asp  Asn Val Thr 
    1130                 1135                 1140             


Ser Leu  Thr Val Leu Ser Asp  Ser Ser Asn Glu Asn  Asp Pro Ala 
    1145                 1150                 1155             


Asn Gln  Val Lys Leu Asp Gln  Asn Gly Lys Phe Ser  Phe Ala Val 
    1160                 1165                 1170             


Thr Ala  Asn Ser Thr Gly Gln  Arg Pro Ile Ala Tyr  Leu Tyr Arg 
    1175                 1180                 1185             


Thr Lys  Asp Gly Gln Thr Val  Arg Gly Thr Leu Asn  Leu Ile Leu 
    1190                 1195                 1200             


Asp Thr  Val Lys Pro Thr Leu  Glu Val Asn Gln Val  Asn Gly Asn 
    1205                 1210                 1215             


Glu Leu  Glu Leu Trp Thr Asn  Asn Pro Lys Phe Val  Leu Ser Gly 
    1220                 1225                 1230             


Lys Val  Asn Asp Asn Leu Asp  Gly Tyr Arg Leu Tyr  Val Asn Gly 
    1235                 1240                 1245             


Asn Asn  Ile Tyr Arg Glu Phe  Leu Asn Ser Gly Tyr  Asn Arg Leu 
    1250                 1255                 1260             


Glu Gly  Leu Asn Thr Asp Thr  Glu Leu Thr Asn Pro  Tyr Gly Asp 
    1265                 1270                 1275             


His Glu  Phe Glu Gln Val Glu  Asn Leu Asn Asp Asn  Asn Asp Gln 
    1280                 1285                 1290             


Pro Thr  Thr His Ile Phe Thr  Val Asn Val Val Asp  Gln Ala Gly 
    1295                 1300                 1305             


Asn Thr  Val Thr Lys Lys Leu  Thr Val His Phe Asp  Pro Asn Tyr 
    1310                 1315                 1320             


Val Val  Pro Thr Asp Asn Thr  Asp Val Val Val Asp  Thr Ser Thr 
    1325                 1330                 1335             


Ser Asp  Thr Asp Gly Val Thr  Glu Thr Lys Pro Ile  Asp Pro Leu 
    1340                 1345                 1350             


Val Gly  Lys Ser Phe Lys Leu  Leu His Asn Ala Tyr  Leu Tyr Asp 
    1355                 1360                 1365             


Gln Asn  Gly Glu Val Val Leu  Thr Asp Val Glu Asn  Ala Lys Ser 
    1370                 1375                 1380             


Leu Leu  Lys Lys Gly Gln Thr  Ile Val Ala Leu Asp  Asn Ala Lys 
    1385                 1390                 1395             


Val Thr  Phe Ile Asn Gly Val  Lys Phe Tyr Arg Val  Gly Asn Asn 
    1400                 1405                 1410             


Thr Phe  Val Lys Thr Ala Asn  Thr Val Leu Gln Ala  Pro Lys Arg 
    1415                 1420                 1425             


Leu Lys  Leu Thr His Asn Ala  Tyr Val Tyr Asp Gln  Lys Gly Asn 
    1430                 1435                 1440             


Val Val  Lys Lys His Gly Lys  Lys Val Leu Leu Lys  Lys Asn Gln 
    1445                 1450                 1455             


Trp Ile  Ser Ala Leu Asn Asn  Ala Asp Lys Tyr Val  Ile Lys Gly 
    1460                 1465                 1470             


Arg Leu  Tyr Tyr Lys Leu Ala  Asp Gly Gln Phe Val  Lys Val Ala 
    1475                 1480                 1485             


Asn Thr  Val Thr Lys Lys Ala  Lys Leu Arg Lys Thr  Val Val Ser 
    1490                 1495                 1500             


<210>  23
<211>  1663
<212>  PRT
<213>  Lactobacillus ultunensis

<400>  23

Met Ser Asn Ser Thr Ala Pro Asn Gly Asn Arg Asn Phe Ser Phe Val 
1               5                   10                  15      


Phe Lys Ala Lys Arg Arg Leu Glu Asn Ile Glu Thr Gln Lys Arg Ala 
            20                  25                  30          


Arg Thr Ile Ile Asn Val Arg Lys Lys Trp Val Ala Ala Ala Ile Ile 
        35                  40                  45              


Ala Leu Ala Ser Gly Ser Thr Val Phe Leu Ser Gln Asn Ala Val Glu 
    50                  55                  60                  


Ala Ala Thr Asn Asp Pro Asp Ala Ser Asp Val Gln Val Lys Val Val 
65                  70                  75                  80  


Gln Gln Asp Gln Lys Gln Asn Gln Asn Thr Thr Ala Asn Val Val Val 
                85                  90                  95      


Ser Asn Ser Asp Ser Thr Lys Thr Gln Val Asn Thr Thr Val Gln Thr 
            100                 105                 110         


Gln Asn Ser Ala Val Val Ser Gly Asp Ser Thr Thr Ala Asn Pro Lys 
        115                 120                 125             


Thr Ser Gln Ala Ser Asn Val Gln Asn Thr Ser Thr Thr Ala Asn Ser 
    130                 135                 140                 


Val Asp Pro Asn Gln Glu Gln Gln Pro Ala Asn Gln Ala Asp His Val 
145                 150                 155                 160 


Lys Gly Asn Val Gln Ser Ala Trp Asp Gln Gly Tyr Arg Gly Gln Gly 
                165                 170                 175     


Thr Val Val Ala Val Ile Asp Ser Gly Ala Asp Pro Thr His Lys Asp 
            180                 185                 190         


Phe Gln Thr Met Pro Glu Asp Pro Lys Leu Ser Lys Asp Asp Met Gln 
        195                 200                 205             


Ala Lys Ile Ser Lys Gln Gly Tyr Gly Lys Tyr Val Asn Glu Lys Phe 
    210                 215                 220                 


Pro Tyr Val Tyr Asn Tyr Ala Asp Arg Asp Asn Asp Tyr Ile Thr Ser 
225                 230                 235                 240 


Asp Asp Thr Asn Ala Asn Asp Ser Pro His Gly Gln His Val Ser Gly 
                245                 250                 255     


Ile Ile Ala Ala Asp Gly Lys Pro Asp Gly Asn Lys Glu Tyr Val Val 
            260                 265                 270         


Gly Val Ala Pro Glu Ala Gln Leu Met Gln Leu Arg Val Phe Gly Gln 
        275                 280                 285             


Phe Ser Asp Glu Lys Thr Asp Asp Val Ala Arg Ala Ile Tyr Asp Ala 
    290                 295                 300                 


Thr Asn Leu Gly Ala Asp Val Ile Gln Met Ser Leu Gly Gln Gly Val 
305                 310                 315                 320 


Ala Asp Gln Gln Leu Thr Asn Ile Glu Gln Lys Ala Val Gln Tyr Ala 
                325                 330                 335     


Ile Asp His Gly Val Phe Val Ser Ile Ser Ala Ser Asn Asn Gly Asn 
            340                 345                 350         


Ser Ala Ser Val Asp Asn Pro Ser Lys Val Gln Asp Ser Gly Tyr Gln 
        355                 360                 365             


Ser Gly Ser Gln Ala Gly Asn Tyr Glu Pro Leu Asn Ser Ser Thr Val 
    370                 375                 380                 


Ala Asn Pro Gly Ala Ser Lys Asn Ala Leu Thr Val Ala Ala Glu Thr 
385                 390                 395                 400 


Ser Asp Thr Gly Asp Leu Ser Asp Met Ala Tyr Phe Ser Ser Trp Gly 
                405                 410                 415     


Pro Ile Gln Asp Phe Thr Leu Lys Pro Asp Leu Ala Ala Pro Gly Tyr 
            420                 425                 430         


Gln Val Val Ser Thr Val Asn His Asp Gln Tyr Gln Thr Met Ser Gly 
        435                 440                 445             


Thr Ser Met Ala Gly Pro Phe Ala Ala Ala Ser Ala Ala Leu Val Ile 
    450                 455                 460                 


Gln Arg Leu Lys Gln Thr Asn Pro Glu Leu Lys Gly Ala Gln Leu Val 
465                 470                 475                 480 


Thr Ala Ala Lys Ala Met Leu Met Asn Thr Ala Lys Pro Gln Lys Gln 
                485                 490                 495     


Leu Gly Tyr Thr Thr Pro Val Ser Pro Arg Arg Gln Gly Ala Gly Gln 
            500                 505                 510         


Ile Asp Val Gly Gly Ala Thr Ala Thr Pro Val Tyr Val Thr Thr Asp 
        515                 520                 525             


Asp Gly Thr Ser Ser Val Ser Leu His Gln Val Asn Glu Asn Thr Lys 
    530                 535                 540                 


Phe Thr Leu Thr Phe His Asn Leu Thr Asp Gln Asn Gln Thr Tyr Thr 
545                 550                 555                 560 


Phe Asp Asp Tyr Gly Gly Gly Tyr Thr Glu Gln Arg Asp Thr Thr Thr 
                565                 570                 575     


Gly Val Phe His Asp Val Gln Leu Ala Gly Ala Arg Val Asn Gly Glu 
            580                 585                 590         


Asn Ser Phe Thr Leu Ala Pro Lys Glu Glu Arg Lys Val Ser Tyr Ser 
        595                 600                 605             


Leu Asp Leu Thr Gly Leu Asn Lys Asn Gln Leu Val Glu Gly Phe Leu 
    610                 615                 620                 


Arg Phe Thr Asn Ala Asn Asn Val Ser Thr Val Ser Val Pro Tyr Leu 
625                 630                 635                 640 


Ala Tyr Tyr Gly Asp Leu Thr Ser Glu Asn Val Phe Asp Gln Asn Ala 
                645                 650                 655     


Asn Glu Glu His Pro Asp Ile Gln Gly Asn Arg Leu Val Asn Glu Gln 
            660                 665                 670         


Asn Tyr Pro Arg Gly Ile Ala Asp Gln Glu Ser Leu Lys Glu Leu Val 
        675                 680                 685             


Asn Val Asp Gly Asn Tyr Asn Trp Gln Glu Val Ala Lys Leu Tyr Glu 
    690                 695                 700                 


Ser Gly Lys Val Ala Phe Ser Pro Asn Asp Asn Gln Lys Ser Asp Leu 
705                 710                 715                 720 


Leu Lys Pro Tyr Val Tyr Leu Lys Gln Asn Val Lys Asp Leu Lys Val 
                725                 730                 735     


Glu Val Leu Asp Ala Gln Gly Lys Val Val Arg Val Val Ser Asp Val 
            740                 745                 750         


Gln Gly Val Asp Lys Ser Tyr Asp Glu Asn Asp Val Thr Lys Asp Thr 
        755                 760                 765             


Ser Leu Ser Val Ser Met Arg Asp Asn Pro Asp Ala Phe Glu Trp Asp 
    770                 775                 780                 


Gly Lys Val Tyr Asn Ser Lys Thr Gly Lys Met Glu Thr Ala Lys Asp 
785                 790                 795                 800 


Gly Asn Tyr Thr Tyr Arg Leu Val Ala Thr Leu Trp Asn Lys Gly Pro 
                805                 810                 815     


His Gln Val Gln Thr Ala Asp Phe Pro Val Val Val Asp Thr Val Ala 
            820                 825                 830         


Pro Thr Leu Ser Asn Ile Lys Tyr Asp Pro Ala Ser His Thr Leu Ser 
        835                 840                 845             


Gly Glu Tyr Gln Asp Thr Gly Ala Gly Phe Thr Asn Tyr Ser Tyr Ala 
    850                 855                 860                 


Thr Val Thr Val Asn Asp Lys Val Phe Gly Tyr Lys Leu Ser Asp Asp 
865                 870                 875                 880 


Glu Ser Gly Phe Asp Asn Thr Glu Lys Thr Lys Gly His Phe Asn Phe 
                885                 890                 895     


Val Leu Gly Gln Asp Ala Leu Ser Ala Leu Thr Thr Ala Thr Asn Lys 
            900                 905                 910         


Met Thr Val Ala Leu Ser Asp Val Ala Asp Asn Thr Ser Leu Ala Thr 
        915                 920                 925             


Val Asp Val Ala Gly Asp His Asp Ser Glu Thr Gly Val Ser Ile Trp 
    930                 935                 940                 


Asn Ala Val Asn Gly Leu Ala Phe Asp Gln Lys Ser Pro Asn Tyr Asn 
945                 950                 955                 960 


Ser Val Thr Lys Thr Tyr Ile Leu Phe Gly Gly Ala Asn His Asp Phe 
                965                 970                 975     


Tyr Leu Asn Gly Lys Leu Val Gln Val Gln Asn Gly Lys Tyr Gln Ala 
            980                 985                 990         


Pro Val Ser Val Asp Thr Thr Glu  Phe Val Phe Ser Thr  Asp Pro Glu 
        995                 1000                 1005             


Gly Arg  His Val Leu Asn Ser  Leu Ser Thr Val Thr  Ala Lys Ala 
    1010                 1015                 1020             


Phe Phe  Asn Trp Gln Lys Thr  Asp Thr Phe Asp Gly  Asn Phe Gly 
    1025                 1030                 1035             


Val Thr  Ile Gly Ser Val Lys  Thr Asn Asp Pro Asn  Asp Thr Val 
    1040                 1045                 1050             


Val Gln  Ala Val Val Thr Lys  Gly Gln Asn Val Lys  Ala Tyr Ala 
    1055                 1060                 1065             


Met Asp  Tyr Phe Thr Gly Glu  Val Tyr Thr Gly Glu  Val Lys Asp 
    1070                 1075                 1080             


Gly Ile  Ala Thr Phe His Val  His Thr Ser Val Asn  Gln Asp Asn 
    1085                 1090                 1095             


Thr Thr  Gly Val Tyr Lys Arg  Ala Leu Leu Thr Gly  Trp Thr Glu 
    1100                 1105                 1110             


Val Asp  Gly Pro Ser Phe Asn  Asp Lys Gln Glu Thr  Ser Arg Gly 
    1115                 1120                 1125             


Gly Val  Ala Ser Ser Asn His  Leu Gly Val Tyr Tyr  Phe Ala Asp 
    1130                 1135                 1140             


Ala Ala  Asp Arg Pro Ile Tyr  Thr Asp Arg Ser Ala  Leu Gly Val 
    1145                 1150                 1155             


Glu Ala  Lys Asp Glu Val Ala  Lys Leu Asp Ser Phe  Gly Pro Gly 
    1160                 1165                 1170             


Phe Tyr  Pro Gly His Ala Pro  Ser Asp Leu Thr Thr  Arg Thr Asp 
    1175                 1180                 1185             


Pro Asn  Pro Asp Ile His Phe  Asp Tyr Met Asn Asp  Asn Asp Thr 
    1190                 1195                 1200             


Thr Arg  Phe Gly Gln Asn Ala  Val Thr Arg Gly Tyr  Tyr Asp Pro 
    1205                 1210                 1215             


Leu Thr  Gln Lys Phe Met Val  Thr Gly Lys Val Asp  Gly Asn Val 
    1220                 1225                 1230             


Ala Ser  Leu Thr Val Leu Gly  Asp Asn Ser Asn Glu  Asn Ala Pro 
    1235                 1240                 1245             


Glu Asn  Gln Val Lys Leu Gly  Asn Asp Gly Lys Phe  Ser Phe Thr 
    1250                 1255                 1260             


Val Thr  Ala Asn Arg Thr Gly  Gln Arg Pro Ile Ala  Tyr Ile Tyr 
    1265                 1270                 1275             


Gln Thr  Lys Asp Gly Gln Arg  Val Arg Gly Thr Leu  Asn Leu Ile 
    1280                 1285                 1290             


Leu Asp  Thr Val Ala Pro Ser  Leu Glu Val Asn Gln  Val Asn Gly 
    1295                 1300                 1305             


Asp Lys  Leu Glu Leu Trp Thr  Asn Asn Pro Lys Phe  Ile Leu Ser 
    1310                 1315                 1320             


Gly Lys  Val Asn Asp Asn Leu  Asp Gly Tyr Arg Leu  Phe Val Asn 
    1325                 1330                 1335             


Gly Asn  Asn Ile Tyr Arg Glu  Phe Leu Asn Ser Gly  Tyr Asn Gln 
    1340                 1345                 1350             


Val Ala  Gly Leu Asn Met Asp  Thr Glu Phe Thr Asn  Pro Tyr Gly 
    1355                 1360                 1365             


Ala His  Asp Phe Glu Glu Val  Glu Asn Leu Asn Asp  Asn Asn Asp 
    1370                 1375                 1380             


Gln Pro  Thr Thr His Val Phe  Thr Val Tyr Val Val  Asp Gln Val 
    1385                 1390                 1395             


Gly Asn  Lys Val Lys Lys Lys  Leu Thr Val His Phe  Asp Pro Asn 
    1400                 1405                 1410             


Tyr Val  Ala Pro Glu Glu Val  Ser Asn Thr Asp Thr  Ser Asn Asn 
    1415                 1420                 1425             


Ser Asn  Thr Ser Gly Thr Val  Glu Asn Leu Ser Ser  Thr Thr Ile 
    1430                 1435                 1440             


Glu Lys  Ser Val Thr Asp Val  Ser Thr Val Gln Pro  Lys Gly Glu 
    1445                 1450                 1455             


Thr Leu  Thr Gly Lys Ser Phe  Asn Leu Leu His Asp  Ala Tyr Ile 
    1460                 1465                 1470             


Tyr Asn  Lys Asp Gly Gln Val  Val Leu Ser Thr Asp  Thr Asn Lys 
    1475                 1480                 1485             


Thr Ser  Leu Leu Lys Lys Gly  Gln Arg Ile Thr Ala  Leu Asp Asn 
    1490                 1495                 1500             


Gly Lys  Thr Val Val Ile Asn  Gly Val Gln Tyr Tyr  Arg Val Gly 
    1505                 1510                 1515             


Asp Asn  Gln Phe Val Lys Val  Ala Asn Thr Val Leu  Gln Ala Gly 
    1520                 1525                 1530             


Lys Arg  Leu Gln Leu Lys His  Asn Ala His Leu Tyr  Asp Lys Asn 
    1535                 1540                 1545             


Gly Lys  Val Val Lys Arg Asn  Gly Lys Thr Ile Leu  Leu Arg Asn 
    1550                 1555                 1560             


Gly Arg  Trp Ile Ser Ala Leu  Asn Asn Ala Asp Lys  Tyr Val Ile 
    1565                 1570                 1575             


Lys Gly  Lys Asn Phe Tyr Lys  Leu Ala Asn Asp Gln  Phe Val Lys 
    1580                 1585                 1590             


Val Ala  Asn Thr Lys Leu Gln  Lys Pro Lys Ala Leu  Lys Leu Thr 
    1595                 1600                 1605             


His Asn  Ala Phe Val Tyr Asp  Lys Asn Gly Lys Arg  Val Lys Lys 
    1610                 1615                 1620             


Ser Lys  Val Leu Lys Lys Gly  Gln Thr Ile Leu Ala  Glu Asn Asn 
    1625                 1630                 1635             


Ala Glu  Lys Phe His Ile Lys  Gly Lys Phe Tyr Tyr  Arg Val Asn 
    1640                 1645                 1650             


Gly Gln  Phe Val Lys Val Ala  Asn Thr Leu 
    1655                 1660             


<210>  24
<211>  1595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Lactobacillus ultunensis protease

<400>  24

Asp Pro Asp Ala Ser Asp Val Gln Val Lys Val Val Gln Gln Asp Gln 
1               5                   10                  15      


Lys Gln Asn Gln Asn Thr Thr Ala Asn Val Val Val Ser Asn Ser Asp 
            20                  25                  30          


Ser Thr Lys Thr Gln Val Asn Thr Thr Val Gln Thr Gln Asn Ser Ala 
        35                  40                  45              


Val Val Ser Gly Asp Ser Thr Thr Ala Asn Pro Lys Thr Ser Gln Ala 
    50                  55                  60                  


Ser Asn Val Gln Asn Thr Ser Thr Thr Ala Asn Ser Val Asp Pro Asn 
65                  70                  75                  80  


Gln Glu Gln Gln Pro Ala Asn Gln Ala Asp His Val Lys Gly Asn Val 
                85                  90                  95      


Gln Ser Ala Trp Asp Gln Gly Tyr Arg Gly Gln Gly Thr Val Val Ala 
            100                 105                 110         


Val Ile Asp Ser Gly Ala Asp Pro Thr His Lys Asp Phe Gln Thr Met 
        115                 120                 125             


Pro Glu Asp Pro Lys Leu Ser Lys Asp Asp Met Gln Ala Lys Ile Ser 
    130                 135                 140                 


Lys Gln Gly Tyr Gly Lys Tyr Val Asn Glu Lys Phe Pro Tyr Val Tyr 
145                 150                 155                 160 


Asn Tyr Ala Asp Arg Asp Asn Asp Tyr Ile Thr Ser Asp Asp Thr Asn 
                165                 170                 175     


Ala Asn Asp Ser Pro His Gly Gln His Val Ser Gly Ile Ile Ala Ala 
            180                 185                 190         


Asp Gly Lys Pro Asp Gly Asn Lys Glu Tyr Val Val Gly Val Ala Pro 
        195                 200                 205             


Glu Ala Gln Leu Met Gln Leu Arg Val Phe Gly Gln Phe Ser Asp Glu 
    210                 215                 220                 


Lys Thr Asp Asp Val Ala Arg Ala Ile Tyr Asp Ala Thr Asn Leu Gly 
225                 230                 235                 240 


Ala Asp Val Ile Gln Met Ser Leu Gly Gln Gly Val Ala Asp Gln Gln 
                245                 250                 255     


Leu Thr Asn Ile Glu Gln Lys Ala Val Gln Tyr Ala Ile Asp His Gly 
            260                 265                 270         


Val Phe Val Ser Ile Ser Ala Ser Asn Asn Gly Asn Ser Ala Ser Val 
        275                 280                 285             


Asp Asn Pro Ser Lys Val Gln Asp Ser Gly Tyr Gln Ser Gly Ser Gln 
    290                 295                 300                 


Ala Gly Asn Tyr Glu Pro Leu Asn Ser Ser Thr Val Ala Asn Pro Gly 
305                 310                 315                 320 


Ala Ser Lys Asn Ala Leu Thr Val Ala Ala Glu Thr Ser Asp Thr Gly 
                325                 330                 335     


Asp Leu Ser Asp Met Ala Tyr Phe Ser Ser Trp Gly Pro Ile Gln Asp 
            340                 345                 350         


Phe Thr Leu Lys Pro Asp Leu Ala Ala Pro Gly Tyr Gln Val Val Ser 
        355                 360                 365             


Thr Val Asn His Asp Gln Tyr Gln Thr Met Ser Gly Thr Ser Met Ala 
    370                 375                 380                 


Gly Pro Phe Ala Ala Ala Ser Ala Ala Leu Val Ile Gln Arg Leu Lys 
385                 390                 395                 400 


Gln Thr Asn Pro Glu Leu Lys Gly Ala Gln Leu Val Thr Ala Ala Lys 
                405                 410                 415     


Ala Met Leu Met Asn Thr Ala Lys Pro Gln Lys Gln Leu Gly Tyr Thr 
            420                 425                 430         


Thr Pro Val Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Gly 
        435                 440                 445             


Gly Ala Thr Ala Thr Pro Val Tyr Val Thr Thr Asp Asp Gly Thr Ser 
    450                 455                 460                 


Ser Val Ser Leu His Gln Val Asn Glu Asn Thr Lys Phe Thr Leu Thr 
465                 470                 475                 480 


Phe His Asn Leu Thr Asp Gln Asn Gln Thr Tyr Thr Phe Asp Asp Tyr 
                485                 490                 495     


Gly Gly Gly Tyr Thr Glu Gln Arg Asp Thr Thr Thr Gly Val Phe His 
            500                 505                 510         


Asp Val Gln Leu Ala Gly Ala Arg Val Asn Gly Glu Asn Ser Phe Thr 
        515                 520                 525             


Leu Ala Pro Lys Glu Glu Arg Lys Val Ser Tyr Ser Leu Asp Leu Thr 
    530                 535                 540                 


Gly Leu Asn Lys Asn Gln Leu Val Glu Gly Phe Leu Arg Phe Thr Asn 
545                 550                 555                 560 


Ala Asn Asn Val Ser Thr Val Ser Val Pro Tyr Leu Ala Tyr Tyr Gly 
                565                 570                 575     


Asp Leu Thr Ser Glu Asn Val Phe Asp Gln Asn Ala Asn Glu Glu His 
            580                 585                 590         


Pro Asp Ile Gln Gly Asn Arg Leu Val Asn Glu Gln Asn Tyr Pro Arg 
        595                 600                 605             


Gly Ile Ala Asp Gln Glu Ser Leu Lys Glu Leu Val Asn Val Asp Gly 
    610                 615                 620                 


Asn Tyr Asn Trp Gln Glu Val Ala Lys Leu Tyr Glu Ser Gly Lys Val 
625                 630                 635                 640 


Ala Phe Ser Pro Asn Asp Asn Gln Lys Ser Asp Leu Leu Lys Pro Tyr 
                645                 650                 655     


Val Tyr Leu Lys Gln Asn Val Lys Asp Leu Lys Val Glu Val Leu Asp 
            660                 665                 670         


Ala Gln Gly Lys Val Val Arg Val Val Ser Asp Val Gln Gly Val Asp 
        675                 680                 685             


Lys Ser Tyr Asp Glu Asn Asp Val Thr Lys Asp Thr Ser Leu Ser Val 
    690                 695                 700                 


Ser Met Arg Asp Asn Pro Asp Ala Phe Glu Trp Asp Gly Lys Val Tyr 
705                 710                 715                 720 


Asn Ser Lys Thr Gly Lys Met Glu Thr Ala Lys Asp Gly Asn Tyr Thr 
                725                 730                 735     


Tyr Arg Leu Val Ala Thr Leu Trp Asn Lys Gly Pro His Gln Val Gln 
            740                 745                 750         


Thr Ala Asp Phe Pro Val Val Val Asp Thr Val Ala Pro Thr Leu Ser 
        755                 760                 765             


Asn Ile Lys Tyr Asp Pro Ala Ser His Thr Leu Ser Gly Glu Tyr Gln 
    770                 775                 780                 


Asp Thr Gly Ala Gly Phe Thr Asn Tyr Ser Tyr Ala Thr Val Thr Val 
785                 790                 795                 800 


Asn Asp Lys Val Phe Gly Tyr Lys Leu Ser Asp Asp Glu Ser Gly Phe 
                805                 810                 815     


Asp Asn Thr Glu Lys Thr Lys Gly His Phe Asn Phe Val Leu Gly Gln 
            820                 825                 830         


Asp Ala Leu Ser Ala Leu Thr Thr Ala Thr Asn Lys Met Thr Val Ala 
        835                 840                 845             


Leu Ser Asp Val Ala Asp Asn Thr Ser Leu Ala Thr Val Asp Val Ala 
    850                 855                 860                 


Gly Asp His Asp Ser Glu Thr Gly Val Ser Ile Trp Asn Ala Val Asn 
865                 870                 875                 880 


Gly Leu Ala Phe Asp Gln Lys Ser Pro Asn Tyr Asn Ser Val Thr Lys 
                885                 890                 895     


Thr Tyr Ile Leu Phe Gly Gly Ala Asn His Asp Phe Tyr Leu Asn Gly 
            900                 905                 910         


Lys Leu Val Gln Val Gln Asn Gly Lys Tyr Gln Ala Pro Val Ser Val 
        915                 920                 925             


Asp Thr Thr Glu Phe Val Phe Ser Thr Asp Pro Glu Gly Arg His Val 
    930                 935                 940                 


Leu Asn Ser Leu Ser Thr Val Thr Ala Lys Ala Phe Phe Asn Trp Gln 
945                 950                 955                 960 


Lys Thr Asp Thr Phe Asp Gly Asn Phe Gly Val Thr Ile Gly Ser Val 
                965                 970                 975     


Lys Thr Asn Asp Pro Asn Asp Thr Val Val Gln Ala Val Val Thr Lys 
            980                 985                 990         


Gly Gln Asn Val Lys Ala Tyr Ala  Met Asp Tyr Phe Thr  Gly Glu Val 
        995                 1000                 1005             


Tyr Thr  Gly Glu Val Lys Asp  Gly Ile Ala Thr Phe  His Val His 
    1010                 1015                 1020             


Thr Ser  Val Asn Gln Asp Asn  Thr Thr Gly Val Tyr  Lys Arg Ala 
    1025                 1030                 1035             


Leu Leu  Thr Gly Trp Thr Glu  Val Asp Gly Pro Ser  Phe Asn Asp 
    1040                 1045                 1050             


Lys Gln  Glu Thr Ser Arg Gly  Gly Val Ala Ser Ser  Asn His Leu 
    1055                 1060                 1065             


Gly Val  Tyr Tyr Phe Ala Asp  Ala Ala Asp Arg Pro  Ile Tyr Thr 
    1070                 1075                 1080             


Asp Arg  Ser Ala Leu Gly Val  Glu Ala Lys Asp Glu  Val Ala Lys 
    1085                 1090                 1095             


Leu Asp  Ser Phe Gly Pro Gly  Phe Tyr Pro Gly His  Ala Pro Ser 
    1100                 1105                 1110             


Asp Leu  Thr Thr Arg Thr Asp  Pro Asn Pro Asp Ile  His Phe Asp 
    1115                 1120                 1125             


Tyr Met  Asn Asp Asn Asp Thr  Thr Arg Phe Gly Gln  Asn Ala Val 
    1130                 1135                 1140             


Thr Arg  Gly Tyr Tyr Asp Pro  Leu Thr Gln Lys Phe  Met Val Thr 
    1145                 1150                 1155             


Gly Lys  Val Asp Gly Asn Val  Ala Ser Leu Thr Val  Leu Gly Asp 
    1160                 1165                 1170             


Asn Ser  Asn Glu Asn Ala Pro  Glu Asn Gln Val Lys  Leu Gly Asn 
    1175                 1180                 1185             


Asp Gly  Lys Phe Ser Phe Thr  Val Thr Ala Asn Arg  Thr Gly Gln 
    1190                 1195                 1200             


Arg Pro  Ile Ala Tyr Ile Tyr  Gln Thr Lys Asp Gly  Gln Arg Val 
    1205                 1210                 1215             


Arg Gly  Thr Leu Asn Leu Ile  Leu Asp Thr Val Ala  Pro Ser Leu 
    1220                 1225                 1230             


Glu Val  Asn Gln Val Asn Gly  Asp Lys Leu Glu Leu  Trp Thr Asn 
    1235                 1240                 1245             


Asn Pro  Lys Phe Ile Leu Ser  Gly Lys Val Asn Asp  Asn Leu Asp 
    1250                 1255                 1260             


Gly Tyr  Arg Leu Phe Val Asn  Gly Asn Asn Ile Tyr  Arg Glu Phe 
    1265                 1270                 1275             


Leu Asn  Ser Gly Tyr Asn Gln  Val Ala Gly Leu Asn  Met Asp Thr 
    1280                 1285                 1290             


Glu Phe  Thr Asn Pro Tyr Gly  Ala His Asp Phe Glu  Glu Val Glu 
    1295                 1300                 1305             


Asn Leu  Asn Asp Asn Asn Asp  Gln Pro Thr Thr His  Val Phe Thr 
    1310                 1315                 1320             


Val Tyr  Val Val Asp Gln Val  Gly Asn Lys Val Lys  Lys Lys Leu 
    1325                 1330                 1335             


Thr Val  His Phe Asp Pro Asn  Tyr Val Ala Pro Glu  Glu Val Ser 
    1340                 1345                 1350             


Asn Thr  Asp Thr Ser Asn Asn  Ser Asn Thr Ser Gly  Thr Val Glu 
    1355                 1360                 1365             


Asn Leu  Ser Ser Thr Thr Ile  Glu Lys Ser Val Thr  Asp Val Ser 
    1370                 1375                 1380             


Thr Val  Gln Pro Lys Gly Glu  Thr Leu Thr Gly Lys  Ser Phe Asn 
    1385                 1390                 1395             


Leu Leu  His Asp Ala Tyr Ile  Tyr Asn Lys Asp Gly  Gln Val Val 
    1400                 1405                 1410             


Leu Ser  Thr Asp Thr Asn Lys  Thr Ser Leu Leu Lys  Lys Gly Gln 
    1415                 1420                 1425             


Arg Ile  Thr Ala Leu Asp Asn  Gly Lys Thr Val Val  Ile Asn Gly 
    1430                 1435                 1440             


Val Gln  Tyr Tyr Arg Val Gly  Asp Asn Gln Phe Val  Lys Val Ala 
    1445                 1450                 1455             


Asn Thr  Val Leu Gln Ala Gly  Lys Arg Leu Gln Leu  Lys His Asn 
    1460                 1465                 1470             


Ala His  Leu Tyr Asp Lys Asn  Gly Lys Val Val Lys  Arg Asn Gly 
    1475                 1480                 1485             


Lys Thr  Ile Leu Leu Arg Asn  Gly Arg Trp Ile Ser  Ala Leu Asn 
    1490                 1495                 1500             


Asn Ala  Asp Lys Tyr Val Ile  Lys Gly Lys Asn Phe  Tyr Lys Leu 
    1505                 1510                 1515             


Ala Asn  Asp Gln Phe Val Lys  Val Ala Asn Thr Lys  Leu Gln Lys 
    1520                 1525                 1530             


Pro Lys  Ala Leu Lys Leu Thr  His Asn Ala Phe Val  Tyr Asp Lys 
    1535                 1540                 1545             


Asn Gly  Lys Arg Val Lys Lys  Ser Lys Val Leu Lys  Lys Gly Gln 
    1550                 1555                 1560             


Thr Ile  Leu Ala Glu Asn Asn  Ala Glu Lys Phe His  Ile Lys Gly 
    1565                 1570                 1575             


Lys Phe  Tyr Tyr Arg Val Asn  Gly Gln Phe Val Lys  Val Ala Asn 
    1580                 1585                 1590             


Thr Leu  
    1595 


<210>  25
<211>  927
<212>  PRT
<213>  Anaerofustis stercorihominis

<400>  25

Met Lys Asn Lys Lys Ile Ile Tyr Thr Leu Leu Ser Ile Leu Leu Ile 
1               5                   10                  15      


Leu Leu Phe Thr Asn Thr Val Tyr Ala Gln Asn Lys Ala Asp Glu Arg 
            20                  25                  30          


Tyr Asp Pro Asn Ser Val Leu Val Val Phe Lys Asp Asn Ile Ser Asn 
        35                  40                  45              


Ser Lys Lys Ser Lys Ile Leu Ser Asn Glu Asn Leu Asn Ile Glu Glu 
    50                  55                  60                  


Thr Val Asp Lys Lys Glu Asn Ile Glu Leu Val Glu Val Pro Lys Asp 
65                  70                  75                  80  


Ser Thr Val Glu Glu Thr Ile Arg Thr Leu Asn Glu Lys Asn Glu Val 
                85                  90                  95      


Leu Tyr Ala Gln Pro Asn Phe Lys Tyr Lys Ala Leu Ala Thr Thr Asn 
            100                 105                 110         


Asp Pro Leu Leu Ser Ala Gln Lys His Leu Thr Trp Thr Asn Ile Ser 
        115                 120                 125             


Gly Ser Gly Thr Thr Ala Trp Asn Tyr Ser Thr Gly Glu Asn Thr Lys 
    130                 135                 140                 


Ile Ala Ile Phe Asp Thr Gly Ala Tyr Thr Ser Asn Pro Asp Leu Ser 
145                 150                 155                 160 


Asn Ile Lys Gly Thr Tyr Asn Ala Ser Thr Gly Ser Ser Ala Lys Ser 
                165                 170                 175     


Ser Val Val Asp Tyr Glu Gly His Gly Thr His Val Ala Gly Ile Ala 
            180                 185                 190         


Ala Ala Cys Gly Asn Asn Lys Ser Leu Gly Ala Gly Val Ala Tyr Asn 
        195                 200                 205             


Ser Asp Leu Tyr Ile Ala Lys Val Ala Asp Ser Asn Gly Asp Ile Ser 
    210                 215                 220                 


Ser Ala Tyr Leu Ile Arg Ala Phe Asp Trp Ala Glu Glu Gln Gly Cys 
225                 230                 235                 240 


Arg Ile Ile Asn Met Ser Leu Gly Gly Tyr Gly Tyr Glu Tyr Asp Ser 
                245                 250                 255     


Asp Gly Lys Val Asn Leu Asp Leu Leu Leu Lys Ser Arg Ile Asp Asp 
            260                 265                 270         


Ala Tyr Asn Lys Ser Asn Asn Ser Ile Leu Thr Val Cys Ala Ala Gly 
        275                 280                 285             


Asn Gly Asp Asp Ile Asn Gly Tyr Pro Tyr Tyr Ser Tyr Pro Ser Asp 
    290                 295                 300                 


Phe Pro Asn Ser Tyr Ser Val Val Ala Leu Gln Tyr Asp Ser Asn Gly 
305                 310                 315                 320 


Asn Pro Thr Arg Ala Lys Tyr Ser Asp Tyr Asn Glu Tyr Lys Asp Ile 
                325                 330                 335     


Ala Ala Pro Gly Ser Asn Ile Asn Ser Leu Ser Asn Thr Ser Thr Ser 
            340                 345                 350         


Lys Leu Ile Thr Glu Ser Gly Thr Ser Met Ala Ala Pro Phe Val Ser 
        355                 360                 365             


Gly Val Ala Gly Leu Ile Met Ser Lys Val Pro Asp Leu Thr Ala Lys 
    370                 375                 380                 


Glu Val Val Asp Ile Ile Asn Ser Thr Ala Asn Lys Ile Gly Ser Tyr 
385                 390                 395                 400 


Ser Tyr Ser Lys Gly Arg Asn Asn Tyr Tyr Gly Tyr Gly Glu Ile Asn 
                405                 410                 415     


Pro Leu Lys Ala Ile Lys Thr Ala Ile Trp Lys Lys Ser Ser Met Thr 
            420                 425                 430         


Ile Ser Lys Thr Ser Asp Ile Ile Gly Glu Asn Lys Lys Leu Asp Ile 
        435                 440                 445             


Thr Leu Asn Met Tyr Thr Glu Val Pro Met Lys Val Glu Val Tyr Asp 
    450                 455                 460                 


Ser Asn Asn Asn Leu Ile Asn Thr Leu Ala Asp Lys Thr Phe Thr Ala 
465                 470                 475                 480 


Gly Glu Thr Lys Leu Ser Trp Asp Tyr Ser Asn Tyr Lys Gly Asp Lys 
                485                 490                 495     


Tyr Ser Ile Gln Ala Thr Met Pro Tyr Lys Asn Ser Lys Asp Lys Val 
            500                 505                 510         


Ile Gln Ser Lys Thr Phe Asn Leu Cys Asp Leu Leu Asp Ile Thr Gly 
        515                 520                 525             


Leu Ser Ser Ser Tyr Thr Pro Leu Ala Asn Thr Ser Ile Thr Gly Asn 
    530                 535                 540                 


Leu Asn Leu Asn Thr Asp Cys Thr Val Ser Ala Gly Phe Tyr Asp Lys 
545                 550                 555                 560 


Asp Asn Lys Leu Val Lys Thr Ile Tyr Asn Lys Asn Thr Ser Leu Thr 
                565                 570                 575     


Lys Glu Asn Lys Ser Phe Ser Trp Asn Tyr Leu Asp Asp Asn Asn Lys 
            580                 585                 590         


Leu Ile Pro Ser Gly Thr Tyr Glu Phe Lys Val Ser Ala Thr Ser Gly 
        595                 600                 605             


Asp Ile Thr Lys Glu Tyr Ser Lys Asn Ile Lys Ile Thr Ile Pro Glu 
    610                 615                 620                 


Lys Ala Ser Ile Ser Lys Met Ser Val Thr Ser Ser Ile Lys Arg Asn 
625                 630                 635                 640 


Asp Phe Asn Lys Ala Ser Ile Lys Tyr Thr Leu Asn Asn Gln Cys Val 
                645                 650                 655     


Thr Ser Ile Lys Ile Tyr Asn Ser Ser Asn Thr Leu Ile Lys Ser Ile 
            660                 665                 670         


Ser Arg Asn Arg Lys Gly Ser Asn Thr Glu Tyr Trp Asn Leu Lys Asp 
        675                 680                 685             


Ser Lys Gly Asn Leu Val Val Ala Gly Thr Tyr Lys Ile Ile Ile Ser 
    690                 695                 700                 


Gly Tyr Asn Ile Ala Gly Lys Phe Glu Thr Thr Lys Tyr Ile Lys Ile 
705                 710                 715                 720 


Thr Asn Pro Ser Lys Val Ser Ile Ser Lys Phe Lys Asn Lys Ser Lys 
                725                 730                 735     


Val Ile Arg Ala Ser Gly Tyr Tyr Thr Ser Thr Lys Phe Tyr Leu Asn 
            740                 745                 750         


Glu Asp Ala Arg Val Lys Val Leu Leu Thr Thr Thr Lys Asn Lys Lys 
        755                 760                 765             


Leu Lys Thr Leu Lys Asn Val Val Met Lys Lys Gly Thr Asn Thr Val 
    770                 775                 780                 


Lys Trp Asn Leu Lys Ser Thr Lys Gly Asn Val Tyr Lys Ala Gly Lys 
785                 790                 795                 800 


Tyr Lys Ile Val Val Tyr Ala Thr Asn Ser Arg Asn Thr Tyr Gln Lys 
                805                 810                 815     


Ser Ser Tyr Val Thr Leu Val Lys Lys Lys Pro Ser Ile Lys Val Ser 
            820                 825                 830         


Lys Val Lys Ser Ser Tyr Lys Ile Arg Gly Ser Lys Asn Asn Pro Thr 
        835                 840                 845             


Ile Lys Val Lys Thr Asn Ile Ile Ala Lys Val Thr Val Arg Val Tyr 
    850                 855                 860                 


Asn Arg Lys Asn Lys Leu Ile Lys Thr Ile Thr Lys Asn Lys Thr Tyr 
865                 870                 875                 880 


Lys Thr Gly Thr Tyr Lys Phe Lys Trp Asn Gly Lys Ser Gly Lys Asn 
                885                 890                 895     


Lys Lys Val Ser Lys Thr Lys Tyr Tyr Phe Lys Val Thr Ile Lys Asn 
            900                 905                 910         


Glu Asn Gly Ser Lys Thr Val Lys Thr Lys Gln Phe Lys Tyr Lys 
        915                 920                 925         


<210>  26
<211>  901
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Anaerofustis stercorihominis protease

<400>  26

Asn Lys Ala Asp Glu Arg Tyr Asp Pro Asn Ser Val Leu Val Val Phe 
1               5                   10                  15      


Lys Asp Asn Ile Ser Asn Ser Lys Lys Ser Lys Ile Leu Ser Asn Glu 
            20                  25                  30          


Asn Leu Asn Ile Glu Glu Thr Val Asp Lys Lys Glu Asn Ile Glu Leu 
        35                  40                  45              


Val Glu Val Pro Lys Asp Ser Thr Val Glu Glu Thr Ile Arg Thr Leu 
    50                  55                  60                  


Asn Glu Lys Asn Glu Val Leu Tyr Ala Gln Pro Asn Phe Lys Tyr Lys 
65                  70                  75                  80  


Ala Leu Ala Thr Thr Asn Asp Pro Leu Leu Ser Ala Gln Lys His Leu 
                85                  90                  95      


Thr Trp Thr Asn Ile Ser Gly Ser Gly Thr Thr Ala Trp Asn Tyr Ser 
            100                 105                 110         


Thr Gly Glu Asn Thr Lys Ile Ala Ile Phe Asp Thr Gly Ala Tyr Thr 
        115                 120                 125             


Ser Asn Pro Asp Leu Ser Asn Ile Lys Gly Thr Tyr Asn Ala Ser Thr 
    130                 135                 140                 


Gly Ser Ser Ala Lys Ser Ser Val Val Asp Tyr Glu Gly His Gly Thr 
145                 150                 155                 160 


His Val Ala Gly Ile Ala Ala Ala Cys Gly Asn Asn Lys Ser Leu Gly 
                165                 170                 175     


Ala Gly Val Ala Tyr Asn Ser Asp Leu Tyr Ile Ala Lys Val Ala Asp 
            180                 185                 190         


Ser Asn Gly Asp Ile Ser Ser Ala Tyr Leu Ile Arg Ala Phe Asp Trp 
        195                 200                 205             


Ala Glu Glu Gln Gly Cys Arg Ile Ile Asn Met Ser Leu Gly Gly Tyr 
    210                 215                 220                 


Gly Tyr Glu Tyr Asp Ser Asp Gly Lys Val Asn Leu Asp Leu Leu Leu 
225                 230                 235                 240 


Lys Ser Arg Ile Asp Asp Ala Tyr Asn Lys Ser Asn Asn Ser Ile Leu 
                245                 250                 255     


Thr Val Cys Ala Ala Gly Asn Gly Asp Asp Ile Asn Gly Tyr Pro Tyr 
            260                 265                 270         


Tyr Ser Tyr Pro Ser Asp Phe Pro Asn Ser Tyr Ser Val Val Ala Leu 
        275                 280                 285             


Gln Tyr Asp Ser Asn Gly Asn Pro Thr Arg Ala Lys Tyr Ser Asp Tyr 
    290                 295                 300                 


Asn Glu Tyr Lys Asp Ile Ala Ala Pro Gly Ser Asn Ile Asn Ser Leu 
305                 310                 315                 320 


Ser Asn Thr Ser Thr Ser Lys Leu Ile Thr Glu Ser Gly Thr Ser Met 
                325                 330                 335     


Ala Ala Pro Phe Val Ser Gly Val Ala Gly Leu Ile Met Ser Lys Val 
            340                 345                 350         


Pro Asp Leu Thr Ala Lys Glu Val Val Asp Ile Ile Asn Ser Thr Ala 
        355                 360                 365             


Asn Lys Ile Gly Ser Tyr Ser Tyr Ser Lys Gly Arg Asn Asn Tyr Tyr 
    370                 375                 380                 


Gly Tyr Gly Glu Ile Asn Pro Leu Lys Ala Ile Lys Thr Ala Ile Trp 
385                 390                 395                 400 


Lys Lys Ser Ser Met Thr Ile Ser Lys Thr Ser Asp Ile Ile Gly Glu 
                405                 410                 415     


Asn Lys Lys Leu Asp Ile Thr Leu Asn Met Tyr Thr Glu Val Pro Met 
            420                 425                 430         


Lys Val Glu Val Tyr Asp Ser Asn Asn Asn Leu Ile Asn Thr Leu Ala 
        435                 440                 445             


Asp Lys Thr Phe Thr Ala Gly Glu Thr Lys Leu Ser Trp Asp Tyr Ser 
    450                 455                 460                 


Asn Tyr Lys Gly Asp Lys Tyr Ser Ile Gln Ala Thr Met Pro Tyr Lys 
465                 470                 475                 480 


Asn Ser Lys Asp Lys Val Ile Gln Ser Lys Thr Phe Asn Leu Cys Asp 
                485                 490                 495     


Leu Leu Asp Ile Thr Gly Leu Ser Ser Ser Tyr Thr Pro Leu Ala Asn 
            500                 505                 510         


Thr Ser Ile Thr Gly Asn Leu Asn Leu Asn Thr Asp Cys Thr Val Ser 
        515                 520                 525             


Ala Gly Phe Tyr Asp Lys Asp Asn Lys Leu Val Lys Thr Ile Tyr Asn 
    530                 535                 540                 


Lys Asn Thr Ser Leu Thr Lys Glu Asn Lys Ser Phe Ser Trp Asn Tyr 
545                 550                 555                 560 


Leu Asp Asp Asn Asn Lys Leu Ile Pro Ser Gly Thr Tyr Glu Phe Lys 
                565                 570                 575     


Val Ser Ala Thr Ser Gly Asp Ile Thr Lys Glu Tyr Ser Lys Asn Ile 
            580                 585                 590         


Lys Ile Thr Ile Pro Glu Lys Ala Ser Ile Ser Lys Met Ser Val Thr 
        595                 600                 605             


Ser Ser Ile Lys Arg Asn Asp Phe Asn Lys Ala Ser Ile Lys Tyr Thr 
    610                 615                 620                 


Leu Asn Asn Gln Cys Val Thr Ser Ile Lys Ile Tyr Asn Ser Ser Asn 
625                 630                 635                 640 


Thr Leu Ile Lys Ser Ile Ser Arg Asn Arg Lys Gly Ser Asn Thr Glu 
                645                 650                 655     


Tyr Trp Asn Leu Lys Asp Ser Lys Gly Asn Leu Val Val Ala Gly Thr 
            660                 665                 670         


Tyr Lys Ile Ile Ile Ser Gly Tyr Asn Ile Ala Gly Lys Phe Glu Thr 
        675                 680                 685             


Thr Lys Tyr Ile Lys Ile Thr Asn Pro Ser Lys Val Ser Ile Ser Lys 
    690                 695                 700                 


Phe Lys Asn Lys Ser Lys Val Ile Arg Ala Ser Gly Tyr Tyr Thr Ser 
705                 710                 715                 720 


Thr Lys Phe Tyr Leu Asn Glu Asp Ala Arg Val Lys Val Leu Leu Thr 
                725                 730                 735     


Thr Thr Lys Asn Lys Lys Leu Lys Thr Leu Lys Asn Val Val Met Lys 
            740                 745                 750         


Lys Gly Thr Asn Thr Val Lys Trp Asn Leu Lys Ser Thr Lys Gly Asn 
        755                 760                 765             


Val Tyr Lys Ala Gly Lys Tyr Lys Ile Val Val Tyr Ala Thr Asn Ser 
    770                 775                 780                 


Arg Asn Thr Tyr Gln Lys Ser Ser Tyr Val Thr Leu Val Lys Lys Lys 
785                 790                 795                 800 


Pro Ser Ile Lys Val Ser Lys Val Lys Ser Ser Tyr Lys Ile Arg Gly 
                805                 810                 815     


Ser Lys Asn Asn Pro Thr Ile Lys Val Lys Thr Asn Ile Ile Ala Lys 
            820                 825                 830         


Val Thr Val Arg Val Tyr Asn Arg Lys Asn Lys Leu Ile Lys Thr Ile 
        835                 840                 845             


Thr Lys Asn Lys Thr Tyr Lys Thr Gly Thr Tyr Lys Phe Lys Trp Asn 
    850                 855                 860                 


Gly Lys Ser Gly Lys Asn Lys Lys Val Ser Lys Thr Lys Tyr Tyr Phe 
865                 870                 875                 880 


Lys Val Thr Ile Lys Asn Glu Asn Gly Ser Lys Thr Val Lys Thr Lys 
                885                 890                 895     


Gln Phe Lys Tyr Lys 
            900     


<210>  27
<211>  1009
<212>  PRT
<213>  Paenisporosarcina sp. HGH0030

<400>  27

Met Asn Ile Lys Lys Gln Leu Lys Ile Phe Leu Phe Ala Tyr Ile Phe 
1               5                   10                  15      


Phe Trp Leu Pro Ala Gln Phe Ala Gly Ala Glu Glu Ile Lys Val Glu 
            20                  25                  30          


Pro Lys Ile Ser Lys Phe Asn Ile Glu Ala Leu Phe Asp Asp Ser Lys 
        35                  40                  45              


Asp Phe Tyr Ser Asn Gln Leu Ile Val Thr Phe Lys Ala Ser Pro Thr 
    50                  55                  60                  


Gly Ser Glu Arg Lys Gln Ile Leu Asp Ser Val Asn Ala Lys Glu Leu 
65                  70                  75                  80  


Ser Ile Gln Val Asn Gly Lys Phe Ala Leu Val Ser Thr Pro Lys Ser 
                85                  90                  95      


Ser Asp Leu Ser Ala Val Ala Lys Glu Leu Leu Lys His Lys Gln Val 
            100                 105                 110         


Glu Phe Val Glu Pro Asn Tyr Gln Leu Glu Asn Thr Phe Arg Pro Lys 
        115                 120                 125             


Asp Pro Ser Tyr Ser Lys Gln Trp His Leu Lys Lys Ile His Ala Ser 
    130                 135                 140                 


Ser Ala Trp Asp Gln Thr Lys Gly Arg Ser Gly Val Ile Val Ala Val 
145                 150                 155                 160 


Ile Asp Glu Gly Val Gln Thr Asn His Pro Asp Leu Lys Gly Lys Phe 
                165                 170                 175     


Val Ser Pro Tyr Asn Ala Val Thr Gly Gly Thr Ser Phe Tyr Ser Gly 
            180                 185                 190         


Asp His Ala Thr His Val Ala Gly Ile Ile Ala Ala Ser Phe Asn Asn 
        195                 200                 205             


Ser Gly Gly Ala Gly Val Ala Pro Asn Ile Lys Ile Met Pro Ile Asn 
    210                 215                 220                 


Val Phe Thr Gly Asp Ser Ala Ser Ser Tyr Asp Val Gly Glu Ala Ile 
225                 230                 235                 240 


Ile Tyr Ala Ala Asp His His Ala Asp Ile Ile Asn Leu Ser Leu Gly 
                245                 250                 255     


Gly Ser Tyr Thr Tyr Ala Met Asp Tyr Ala Thr Gln Tyr Ala Lys Ala 
            260                 265                 270         


Lys Asp Val Leu Ile Ile Ala Ala Ala Gly Asn Glu Arg Ser Tyr Glu 
        275                 280                 285             


Leu Ser Tyr Pro Ala Ala Leu Asp Gly Val Ile Gly Val Ser Ala Thr 
    290                 295                 300                 


Asp Ser Asn Asp Glu Ile Thr Asp Phe Ser Asn Tyr Gly Ser Tyr Ile 
305                 310                 315                 320 


Asp Leu Ala Ala Pro Gly Glu Gly Ile Phe Ser Ser Leu Ser Gly Ser 
                325                 330                 335     


Lys Tyr Gly Ala Met Asp Gly Thr Ser Met Ala Ala Pro Val Val Ser 
            340                 345                 350         


Gly Val Ala Ala Leu Val Leu Ser Lys Asn Pro Leu Leu Thr Ser Asp 
        355                 360                 365             


Gln Leu Glu Lys Ile Leu Thr Lys Ser Ser Val Asp Leu Tyr His Arg 
    370                 375                 380                 


Gly Trp Asp Asp Phe Tyr Gly Tyr Gly Arg Val Asp Ala Tyr Arg Ala 
385                 390                 395                 400 


Leu Gln Phe Thr Thr Ser Ala Ile Ser Asn Leu Lys Leu Ser Ser Thr 
                405                 410                 415     


Lys Phe Thr Met Asn Gly Ser Asn Lys Thr Ala Phe Ser Phe Glu Gly 
            420                 425                 430         


Val Lys Gly Ser Lys Ile Ser Leu Tyr Leu Gln Asn Ser Lys Gly Thr 
        435                 440                 445             


Thr Ile Lys Lys Ile Val Ser Tyr Lys Asp Trp Ser Gly Gly Lys Phe 
    450                 455                 460                 


Ser Ala Ser Trp Asp Gly Arg Met Asp Asn Gly Met Tyr Ala Ser Thr 
465                 470                 475                 480 


Gly Thr Tyr Lys Ile Ile Ala Ala Val Ser Gly Asn Gly Glu Asn Leu 
                485                 490                 495     


His Leu Ser Ala Thr Leu Lys Val Ile Asp Lys Ile Val Pro Ser Ile 
            500                 505                 510         


Asn Leu Ser Gly Ser Val Asn Tyr Ser Pro Thr Val Thr Gly Lys Leu 
        515                 520                 525             


Thr Val Pro Tyr Glu Leu Asn Lys Asn Ala Lys Val Thr Ala Phe Ile 
    530                 535                 540                 


Lys Asp Lys Asn Asn Lys Ile Ile Lys Ser Ile Leu Asn Asn Ser Ser 
545                 550                 555                 560 


Val Ser Arg Gly Gln Arg Thr Val Gln Trp Asp Gly Lys Asp Ser Glu 
                565                 570                 575     


Gly Asn Arg Val Lys Asp Gly Val Tyr Ser Leu Glu Met Ser Leu Val 
            580                 585                 590         


Asp Ala Asn Lys Ile Lys Gly Thr Ser Arg Lys Phe Ser Ile Thr Val 
        595                 600                 605             


Asp Thr Ile Ile Pro Thr Ala Lys Ile Ala Leu Ser Ser Glu Leu Met 
    610                 615                 620                 


Lys Leu Asn Gly Ser Leu Leu Asn Met Gly Lys Ile Asp Val Ser Glu 
625                 630                 635                 640 


Thr Val Phe Leu Thr Thr Tyr Ile Ala Asn Asp Asn Gly Val Lys Val 
                645                 650                 655     


Arg Lys Ile Asp Thr Glu Lys Ser Ile Lys Lys Gly Ala Tyr Ser Leu 
            660                 665                 670         


Asn Trp Asp Gly Lys Asn Glu Asn Ser Glu Phe Val Ala Glu Gly Asn 
        675                 680                 685             


Tyr His Leu Leu Phe Glu Leu Leu Asp Ser Ala Gly Asn Lys Ala Ser 
    690                 695                 700                 


Leu Lys Ser Thr Thr Phe Ala Phe Gln Asp Trp Asn Gln Pro Val Ile 
705                 710                 715                 720 


Glu Gly Asp Ala Asn Tyr Phe Phe Thr Ser Asp Gly Lys Gln Thr Phe 
                725                 730                 735     


Ser Tyr Lys Leu Ser Lys Pro Gly Ile Val Thr Ile Gln Leu Phe Lys 
            740                 745                 750         


Asn Asp Asn Leu Val Ser Thr Ile Glu Gln Asn Val Pro Lys Ser Gln 
        755                 760                 765             


Gly Asn Gln Ser Phe Val Trp Asp Gly Lys Asp Gln Ser Gly Thr Ile 
    770                 775                 780                 


Leu Pro Asp Gly Gln Tyr Ser Tyr Lys Ile Ser Ile Val Asp Ala Tyr 
785                 790                 795                 800 


Asn Leu Ser Gln Thr Tyr Lys Gly Ile Met Asn Ile Ala Leu Thr Gln 
                805                 810                 815     


Ile Glu Ile Gln Tyr Pro Thr Val Val Gln Phe Ile Asp Asp Asp Thr 
            820                 825                 830         


Ala Glu Ile Phe Tyr Lys Leu Ser Gln Gln Ala Asn Val Thr Ile Glu 
        835                 840                 845             


Ile Tyr Glu Gly Asn Ala Lys Ile Arg Thr Ile Ile Ser Asp Lys Lys 
    850                 855                 860                 


Thr Asp Lys Gly Ile Asn His Phe Ile Trp Asp Gly Tyr Asp Asp Asn 
865                 870                 875                 880 


Gly Asp Leu Val Tyr Ser Asp Glu Leu Ile Tyr Lys Ile Lys Val Ile 
                885                 890                 895     


Asn Thr Ser Gly Asn Glu Gln Thr Val Leu Gly Lys Ile Thr Asn Asp 
            900                 905                 910         


Asp Leu Pro Ile Trp Leu Val Asp His Lys Tyr Thr Phe Ser Ser Ser 
        915                 920                 925             


Asp Asn Tyr Ser Thr Tyr Tyr Thr His Leu Lys Leu Thr Leu Val Val 
    930                 935                 940                 


Lys Ala Pro Val Lys Val Glu Leu Phe Val Trp Asp Ser Tyr Asn Asp 
945                 950                 955                 960 


Leu Ile Asp Glu Lys Glu Tyr Asn Leu Lys Asn Gly Ile Asn Asn Leu 
                965                 970                 975     


Val Tyr Thr Lys Phe Pro Val Ala Ser Val Asn Thr Tyr Gly Leu Leu 
            980                 985                 990         


Tyr Thr Asp Ser Leu Gly Asn Gln  Tyr Phe Phe Thr Ile  Glu Glu Ala 
        995                 1000                 1005             


Tyr 
    


<210>  28
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Paenisporosarcina sp. HGH0030 protease

<400>  28

Glu Glu Ile Lys Val Glu Pro Lys Ile Ser Lys Phe Asn Ile Glu Ala 
1               5                   10                  15      


Leu Phe Asp Asp Ser Lys Asp Phe Tyr Ser Asn Gln Leu Ile Val Thr 
            20                  25                  30          


Phe Lys Ala Ser Pro Thr Gly Ser Glu Arg Lys Gln Ile Leu Asp Ser 
        35                  40                  45              


Val Asn Ala Lys Glu Leu Ser Ile Gln Val Asn Gly Lys Phe Ala Leu 
    50                  55                  60                  


Val Ser Thr Pro Lys Ser Ser Asp Leu Ser Ala Val Ala Lys Glu Leu 
65                  70                  75                  80  


Leu Lys His Lys Gln Val Glu Phe Val Glu Pro Asn Tyr Gln Leu Glu 
                85                  90                  95      


Asn Thr Phe Arg Pro Lys Asp Pro Ser Tyr Ser Lys Gln Trp His Leu 
            100                 105                 110         


Lys Lys Ile His Ala Ser Ser Ala Trp Asp Gln Thr Lys Gly Arg Ser 
        115                 120                 125             


Gly Val Ile Val Ala Val Ile Asp Glu Gly Val Gln Thr Asn His Pro 
    130                 135                 140                 


Asp Leu Lys Gly Lys Phe Val Ser Pro Tyr Asn Ala Val Thr Gly Gly 
145                 150                 155                 160 


Thr Ser Phe Tyr Ser Gly Asp His Ala Thr His Val Ala Gly Ile Ile 
                165                 170                 175     


Ala Ala Ser Phe Asn Asn Ser Gly Gly Ala Gly Val Ala Pro Asn Ile 
            180                 185                 190         


Lys Ile Met Pro Ile Asn Val Phe Thr Gly Asp Ser Ala Ser Ser Tyr 
        195                 200                 205             


Asp Val Gly Glu Ala Ile Ile Tyr Ala Ala Asp His His Ala Asp Ile 
    210                 215                 220                 


Ile Asn Leu Ser Leu Gly Gly Ser Tyr Thr Tyr Ala Met Asp Tyr Ala 
225                 230                 235                 240 


Thr Gln Tyr Ala Lys Ala Lys Asp Val Leu Ile Ile Ala Ala Ala Gly 
                245                 250                 255     


Asn Glu Arg Ser Tyr Glu Leu Ser Tyr Pro Ala Ala Leu Asp Gly Val 
            260                 265                 270         


Ile Gly Val Ser Ala Thr Asp Ser Asn Asp Glu Ile Thr Asp Phe Ser 
        275                 280                 285             


Asn Tyr Gly Ser Tyr Ile Asp Leu Ala Ala Pro Gly Glu Gly Ile Phe 
    290                 295                 300                 


Ser Ser Leu Ser Gly Ser Lys Tyr Gly Ala Met Asp Gly Thr Ser Met 
305                 310                 315                 320 


Ala Ala Pro Val Val Ser Gly Val Ala Ala Leu Val Leu Ser Lys Asn 
                325                 330                 335     


Pro Leu Leu Thr Ser Asp Gln Leu Glu Lys Ile Leu Thr Lys Ser Ser 
            340                 345                 350         


Val Asp Leu Tyr His Arg Gly Trp Asp Asp Phe Tyr Gly Tyr Gly Arg 
        355                 360                 365             


Val Asp Ala Tyr Arg Ala Leu Gln Phe Thr Thr Ser Ala Ile Ser Asn 
    370                 375                 380                 


Leu Lys Leu Ser Ser Thr Lys Phe Thr Met Asn Gly Ser Asn Lys Thr 
385                 390                 395                 400 


Ala Phe Ser Phe Glu Gly Val Lys Gly Ser Lys Ile Ser Leu Tyr Leu 
                405                 410                 415     


Gln Asn Ser Lys Gly Thr Thr Ile Lys Lys Ile Val Ser Tyr Lys Asp 
            420                 425                 430         


Trp Ser Gly Gly Lys Phe Ser Ala Ser Trp Asp Gly Arg Met Asp Asn 
        435                 440                 445             


Gly Met Tyr Ala Ser Thr Gly Thr Tyr Lys Ile Ile Ala Ala Val Ser 
    450                 455                 460                 


Gly Asn Gly Glu Asn Leu His Leu Ser Ala Thr Leu Lys Val Ile Asp 
465                 470                 475                 480 


Lys Ile Val Pro Ser Ile Asn Leu Ser Gly Ser Val Asn Tyr Ser Pro 
                485                 490                 495     


Thr Val Thr Gly Lys Leu Thr Val Pro Tyr Glu Leu Asn Lys Asn Ala 
            500                 505                 510         


Lys Val Thr Ala Phe Ile Lys Asp Lys Asn Asn Lys Ile Ile Lys Ser 
        515                 520                 525             


Ile Leu Asn Asn Ser Ser Val Ser Arg Gly Gln Arg Thr Val Gln Trp 
    530                 535                 540                 


Asp Gly Lys Asp Ser Glu Gly Asn Arg Val Lys Asp Gly Val Tyr Ser 
545                 550                 555                 560 


Leu Glu Met Ser Leu Val Asp Ala Asn Lys Ile Lys Gly Thr Ser Arg 
                565                 570                 575     


Lys Phe Ser Ile Thr Val Asp Thr Ile Ile Pro Thr Ala Lys Ile Ala 
            580                 585                 590         


Leu Ser Ser Glu Leu Met Lys Leu Asn Gly Ser Leu Leu Asn Met Gly 
        595                 600                 605             


Lys Ile Asp Val Ser Glu Thr Val Phe Leu Thr Thr Tyr Ile Ala Asn 
    610                 615                 620                 


Asp Asn Gly Val Lys Val Arg Lys Ile Asp Thr Glu Lys Ser Ile Lys 
625                 630                 635                 640 


Lys Gly Ala Tyr Ser Leu Asn Trp Asp Gly Lys Asn Glu Asn Ser Glu 
                645                 650                 655     


Phe Val Ala Glu Gly Asn Tyr His Leu Leu Phe Glu Leu Leu Asp Ser 
            660                 665                 670         


Ala Gly Asn Lys Ala Ser Leu Lys Ser Thr Thr Phe Ala Phe Gln Asp 
        675                 680                 685             


Trp Asn Gln Pro Val Ile Glu Gly Asp Ala Asn Tyr Phe Phe Thr Ser 
    690                 695                 700                 


Asp Gly Lys Gln Thr Phe Ser Tyr Lys Leu Ser Lys Pro Gly Ile Val 
705                 710                 715                 720 


Thr Ile Gln Leu Phe Lys Asn Asp Asn Leu Val Ser Thr Ile Glu Gln 
                725                 730                 735     


Asn Val Pro Lys Ser Gln Gly Asn Gln Ser Phe Val Trp Asp Gly Lys 
            740                 745                 750         


Asp Gln Ser Gly Thr Ile Leu Pro Asp Gly Gln Tyr Ser Tyr Lys Ile 
        755                 760                 765             


Ser Ile Val Asp Ala Tyr Asn Leu Ser Gln Thr Tyr Lys Gly Ile Met 
    770                 775                 780                 


Asn Ile Ala Leu Thr Gln Ile Glu Ile Gln Tyr Pro Thr Val Val Gln 
785                 790                 795                 800 


Phe Ile Asp Asp Asp Thr Ala Glu Ile Phe Tyr Lys Leu Ser Gln Gln 
                805                 810                 815     


Ala Asn Val Thr Ile Glu Ile Tyr Glu Gly Asn Ala Lys Ile Arg Thr 
            820                 825                 830         


Ile Ile Ser Asp Lys Lys Thr Asp Lys Gly Ile Asn His Phe Ile Trp 
        835                 840                 845             


Asp Gly Tyr Asp Asp Asn Gly Asp Leu Val Tyr Ser Asp Glu Leu Ile 
    850                 855                 860                 


Tyr Lys Ile Lys Val Ile Asn Thr Ser Gly Asn Glu Gln Thr Val Leu 
865                 870                 875                 880 


Gly Lys Ile Thr Asn Asp Asp Leu Pro Ile Trp Leu Val Asp His Lys 
                885                 890                 895     


Tyr Thr Phe Ser Ser Ser Asp Asn Tyr Ser Thr Tyr Tyr Thr His Leu 
            900                 905                 910         


Lys Leu Thr Leu Val Val Lys Ala Pro Val Lys Val Glu Leu Phe Val 
        915                 920                 925             


Trp Asp Ser Tyr Asn Asp Leu Ile Asp Glu Lys Glu Tyr Asn Leu Lys 
    930                 935                 940                 


Asn Gly Ile Asn Asn Leu Val Tyr Thr Lys Phe Pro Val Ala Ser Val 
945                 950                 955                 960 


Asn Thr Tyr Gly Leu Leu Tyr Thr Asp Ser Leu Gly Asn Gln Tyr Phe 
                965                 970                 975     


Phe Thr Ile Glu Glu Ala Tyr 
            980             


<210>  29
<211>  1133
<212>  PRT
<213>  Actinomyces sp. ICM47

<400>  29

Met Thr Pro Lys Lys Pro Ala Lys Leu Phe Ala Ile Ala Gly Ala Cys 
1               5                   10                  15      


Ala Val Ala Ile Ala Leu Pro Thr Ser Leu Ala Met Pro Gly Ser Leu 
            20                  25                  30          


Leu His Gln Ala Gly Ser Asp Ala Asp Ala Ala Gln Ser Ala Gln Ser 
        35                  40                  45              


Ala Ala Asp Glu Ala Ala Ala Ser Glu Pro Ala Pro Glu Leu Pro Val 
    50                  55                  60                  


Gly Asp Val Asp Asn Ala Leu Thr Ser Ala Asp Gly Glu Ser Leu Leu 
65                  70                  75                  80  


Asp Glu Gly Asp Pro Ala Thr Thr Glu Glu Asp Ser Ser Thr Val Val 
                85                  90                  95      


Asp Met Ile Val Gln Leu Glu Asp Gly Thr Asp Thr Ala Ala Ala Leu 
            100                 105                 110         


Ala Ser Ile Asn Ser Ala Val Ala Ala Ala Tyr Pro Asp Ala Ser Ala 
        115                 120                 125             


Glu Val Ser Arg Glu Tyr Thr Asn Ala Phe Thr Gly Phe Ala Leu Ser 
    130                 135                 140                 


Ala Pro Ile Gly Ser Met Asp Ala Ile Arg Gly Val Ser Gly Val Gln 
145                 150                 155                 160 


Ser Ala Phe Leu Asp His Glu Thr Gln Val Ser Asp Glu Gly Asp Asp 
                165                 170                 175     


Thr Pro Ala Asp Ala Glu Gly Thr Gly Gly Ala Asp Ala Ser Ala Asp 
            180                 185                 190         


Ser Gly Ser Ala Ala Asp Ala Glu Ser Asn Pro Met Ala Ala Met Arg 
        195                 200                 205             


Ala Ala Gln His Gly Asp Val Leu Ser Ala Gln Val Met Met Lys Ala 
    210                 215                 220                 


Asp Lys Ile Ser Gln Thr Gly Ala Gly Lys Val Val Ala Ile Ile Asp 
225                 230                 235                 240 


Thr Gly Val Asp Met Ser His Pro Ala Phe Ala Gly Gly Leu His Gly 
                245                 250                 255     


Thr Pro Ala Ile Asp Ser Ser Lys Gly Ala Ser Leu Ala Arg Gln Val 
            260                 265                 270         


Gly Lys Ser Gly Thr Tyr Val Asn Gln Lys Phe Pro Phe Ala Tyr Asp 
        275                 280                 285             


Tyr Ala Asp Gly Asp Asn Asp Ala Ser Pro Ala Gly Ser His Gly Thr 
    290                 295                 300                 


His Val Ala Gly Ile Thr Ala Ala Asn Gly Ser Gln Ile Thr Gly Ile 
305                 310                 315                 320 


Ala Pro Asp Ala Gln Ile Ile Val Gly Lys Val Ala Arg Ser Arg Gly 
                325                 330                 335     


Gly Ile Pro Asp Ser Ala Leu Leu Ala Ala Leu Asp Asp Met Ala Val 
            340                 345                 350         


Ile Lys Pro Asp Val Val Asn Leu Ser Leu Gly Arg Thr Ala Gly Met 
        355                 360                 365             


Asp Ser Ala Ala Asp Thr Leu Phe Ala Gly Val Tyr Glu Lys Leu Gln 
    370                 375                 380                 


Asn Asn Gly Thr Ile Val Asp Val Ala Ala Gly Asn Glu Tyr Ser Ala 
385                 390                 395                 400 


Ala Tyr Gly Asn Lys Ser Gly Lys Asn Leu Pro Tyr Ala Ser Asp Pro 
                405                 410                 415     


Asp Ser Ser Thr Leu Gly Glu Pro Ser Thr Phe Ala Pro Val Val Ser 
            420                 425                 430         


Val Ala Ser Ile Glu Asn Ala Arg Asn Gly Arg Gly Ala Tyr Lys Met 
        435                 440                 445             


Ser Asp Phe Ser Ser Trp Gly Val Ser Pro Asp Met Arg Leu Lys Pro 
    450                 455                 460                 


Glu Val Thr Ala Pro Gly Gly Asn Ile Tyr Ser Ser Val Pro Gly Gly 
465                 470                 475                 480 


Gly Tyr Gln Tyr Met Ser Gly Thr Ser Met Ala Thr Pro Gln Ile Thr 
                485                 490                 495     


Gly Val Ser Ala Val Val Leu Glu Arg Val Gln Asn Asp Pro Leu Phe 
            500                 505                 510         


Ser Ser Met Ser Ala Arg Gln Lys Ala Asp Val Val Gln Asn Leu Ile 
        515                 520                 525             


Met Gly Thr Ala Val Pro Val Ala Asp Pro Asn Ala Ser Ser Gly Ala 
    530                 535                 540                 


Tyr Tyr Ser Pro Arg Lys Gln Gly Ala Gly Leu Val Asn Val Gln Ala 
545                 550                 555                 560 


Ala Thr Thr Ser Ser Val Tyr Pro Thr Val Asn Gly Ala Ala Asp Ser 
                565                 570                 575     


Ser Arg Pro Lys Ala Glu Leu Gly Asp Gly Thr Lys Gly Trp His Phe 
            580                 585                 590         


Asp Val Thr Leu His Asn Met Ser Gly Thr Ala Ala Thr Tyr Asp Leu 
        595                 600                 605             


Ser Ala Gln Ala Leu Ser Glu Asn Ile Ser Gly Gly Leu Phe Thr Gly 
    610                 615                 620                 


Ser Ser Thr Asp Trp Asn Gly Lys Gly Val Ser Val Ser Phe Ser Asn 
625                 630                 635                 640 


Asn Ser Val Thr Val Pro Ala Lys Gly Glu Ala Thr Val Gly Ile Asp 
                645                 650                 655     


Val Thr Pro Gly Ser Gln Phe Ala Gln Trp Val Ser Ala Asn Ala Pro 
            660                 665                 670         


Ser Gly Thr Phe Leu Asp Gly Phe Val Arg Phe Thr Ala Arg Thr Asn 
        675                 680                 685             


Gly Gln Ser Asp Met Thr Val Pro Tyr Leu Gly Phe Tyr Gly Ser Trp 
    690                 695                 700                 


Gly Thr Pro Ser Ile Phe Asp Gln Met Leu Ser Glu Gly Asp Gly His 
705                 710                 715                 720 


Ala Ala Ser Ser Ala Ile Tyr Asn Gly Gln Asn Gly Ser Leu Leu Gly 
                725                 730                 735     


Tyr Asn Pro Leu Val Lys Gly Ser Glu Arg Glu Gly Arg Pro Asn Ala 
            740                 745                 750         


Asp Arg Tyr Val Ile Ser Arg Ser Thr Ala Ser Gly Ala Pro Thr Ala 
        755                 760                 765             


Ile Thr Pro Arg Thr Gly Thr Leu Arg Ser Val His Thr Met Thr Thr 
    770                 775                 780                 


Thr Tyr Ala Asn Glu Ala Gly Lys Ser Val Ala Ser Phe Thr Ser Thr 
785                 790                 795                 800 


Gln Asn Trp Lys Ser Val Tyr Asn Ser Asp Glu Arg Arg Met Thr Trp 
                805                 810                 815     


Val Glu Glu Asn His Glu Ser Arg Ser Ile Asn Leu Asn Asp Tyr Lys 
            820                 825                 830         


Tyr Ser Arg Leu Pro Asp Gly Lys Tyr Thr Leu Thr Ile Ser Ala Ser 
        835                 840                 845             


Asn Asp Gly Pro Ser Pro Thr Lys Gln Ser Leu Thr Tyr Asn Phe Arg 
    850                 855                 860                 


Val Asp Thr Lys Ala Pro Val Val Glu Arg Ala Thr Leu Ser Asn Gly 
865                 870                 875                 880 


Gly Ser Thr Leu Asn Val Glu Ile Ser Asp Glu Ser Pro Leu Ala Gly 
                885                 890                 895     


Phe Thr Val Asn Asp Pro Asn Ser Gly Gln Tyr Ile Tyr Arg Asp Val 
            900                 905                 910         


Ile Arg Asn Asp Ala Asp Gln Thr Tyr Ser Asn Gly Arg Tyr His Tyr 
        915                 920                 925             


Thr Ala Thr Val Asp Met Ser Arg Val Ser Gly Gly Asn Ser Ser Lys 
    930                 935                 940                 


Pro Tyr Val Leu Ala Trp Asp Tyr Gly Leu Asn His Ser Lys Ala Thr 
945                 950                 955                 960 


Thr Ile Gly Ala Ala Thr Gly Asn Gly Gly Gly Asn Asp Gly Gly Asn 
                965                 970                 975     


Thr Gly Asp Gln Pro Gly Asn Gly Gly Gly Asp Asn Gly Gly Asn Thr 
            980                 985                 990         


Gly Asp Gln Pro Gly Asn Gly Gly  Gly Asn Asp Gly Gly  Asn Thr Gly 
        995                 1000                 1005             


Asp Gln  Pro Gly Asn Gly Gly  Gly Asp Gly Gly Gly  Ile Gly Gly 
    1010                 1015                 1020             


Asn Val  Cys Ser Pro Ser Met  Gly Gly Arg Trp Val  Thr Asp Gly 
    1025                 1030                 1035             


Tyr Arg  Trp Ala Trp Gln Cys  Asn Asn Gly Ala Tyr  Leu Arg Asn 
    1040                 1045                 1050             


Gly Trp  Tyr Leu Ile Asp Gly  Arg Tyr Tyr Tyr Phe  Asp Gly Asn 
    1055                 1060                 1065             


Gly Tyr  Met Arg Ser Gly Trp  Val Arg Gly Arg Gly  Ser Trp Tyr 
    1070                 1075                 1080             


Tyr Leu  Gly Asn Asn Gly Ala  Met Gln Thr Gly Trp  Val Lys Ile 
    1085                 1090                 1095             


Gly Gly  Arg Trp Tyr Tyr Leu  Gly Ser Asp Gly Ala  Met Tyr Ser 
    1100                 1105                 1110             


Gly Thr  Arg Thr Ile Asp Gly  Asn Ser Tyr Glu Phe  Ser Glu Ser 
    1115                 1120                 1125             


Gly Glu  Trp Ile Lys 
    1130             


<210>  30
<211>  1105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Actinomyces sp. ICM47 protease

<400>  30

Pro Gly Ser Leu Leu His Gln Ala Gly Ser Asp Ala Asp Ala Ala Gln 
1               5                   10                  15      


Ser Ala Gln Ser Ala Ala Asp Glu Ala Ala Ala Ser Glu Pro Ala Pro 
            20                  25                  30          


Glu Leu Pro Val Gly Asp Val Asp Asn Ala Leu Thr Ser Ala Asp Gly 
        35                  40                  45              


Glu Ser Leu Leu Asp Glu Gly Asp Pro Ala Thr Thr Glu Glu Asp Ser 
    50                  55                  60                  


Ser Thr Val Val Asp Met Ile Val Gln Leu Glu Asp Gly Thr Asp Thr 
65                  70                  75                  80  


Ala Ala Ala Leu Ala Ser Ile Asn Ser Ala Val Ala Ala Ala Tyr Pro 
                85                  90                  95      


Asp Ala Ser Ala Glu Val Ser Arg Glu Tyr Thr Asn Ala Phe Thr Gly 
            100                 105                 110         


Phe Ala Leu Ser Ala Pro Ile Gly Ser Met Asp Ala Ile Arg Gly Val 
        115                 120                 125             


Ser Gly Val Gln Ser Ala Phe Leu Asp His Glu Thr Gln Val Ser Asp 
    130                 135                 140                 


Glu Gly Asp Asp Thr Pro Ala Asp Ala Glu Gly Thr Gly Gly Ala Asp 
145                 150                 155                 160 


Ala Ser Ala Asp Ser Gly Ser Ala Ala Asp Ala Glu Ser Asn Pro Met 
                165                 170                 175     


Ala Ala Met Arg Ala Ala Gln His Gly Asp Val Leu Ser Ala Gln Val 
            180                 185                 190         


Met Met Lys Ala Asp Lys Ile Ser Gln Thr Gly Ala Gly Lys Val Val 
        195                 200                 205             


Ala Ile Ile Asp Thr Gly Val Asp Met Ser His Pro Ala Phe Ala Gly 
    210                 215                 220                 


Gly Leu His Gly Thr Pro Ala Ile Asp Ser Ser Lys Gly Ala Ser Leu 
225                 230                 235                 240 


Ala Arg Gln Val Gly Lys Ser Gly Thr Tyr Val Asn Gln Lys Phe Pro 
                245                 250                 255     


Phe Ala Tyr Asp Tyr Ala Asp Gly Asp Asn Asp Ala Ser Pro Ala Gly 
            260                 265                 270         


Ser His Gly Thr His Val Ala Gly Ile Thr Ala Ala Asn Gly Ser Gln 
        275                 280                 285             


Ile Thr Gly Ile Ala Pro Asp Ala Gln Ile Ile Val Gly Lys Val Ala 
    290                 295                 300                 


Arg Ser Arg Gly Gly Ile Pro Asp Ser Ala Leu Leu Ala Ala Leu Asp 
305                 310                 315                 320 


Asp Met Ala Val Ile Lys Pro Asp Val Val Asn Leu Ser Leu Gly Arg 
                325                 330                 335     


Thr Ala Gly Met Asp Ser Ala Ala Asp Thr Leu Phe Ala Gly Val Tyr 
            340                 345                 350         


Glu Lys Leu Gln Asn Asn Gly Thr Ile Val Asp Val Ala Ala Gly Asn 
        355                 360                 365             


Glu Tyr Ser Ala Ala Tyr Gly Asn Lys Ser Gly Lys Asn Leu Pro Tyr 
    370                 375                 380                 


Ala Ser Asp Pro Asp Ser Ser Thr Leu Gly Glu Pro Ser Thr Phe Ala 
385                 390                 395                 400 


Pro Val Val Ser Val Ala Ser Ile Glu Asn Ala Arg Asn Gly Arg Gly 
                405                 410                 415     


Ala Tyr Lys Met Ser Asp Phe Ser Ser Trp Gly Val Ser Pro Asp Met 
            420                 425                 430         


Arg Leu Lys Pro Glu Val Thr Ala Pro Gly Gly Asn Ile Tyr Ser Ser 
        435                 440                 445             


Val Pro Gly Gly Gly Tyr Gln Tyr Met Ser Gly Thr Ser Met Ala Thr 
    450                 455                 460                 


Pro Gln Ile Thr Gly Val Ser Ala Val Val Leu Glu Arg Val Gln Asn 
465                 470                 475                 480 


Asp Pro Leu Phe Ser Ser Met Ser Ala Arg Gln Lys Ala Asp Val Val 
                485                 490                 495     


Gln Asn Leu Ile Met Gly Thr Ala Val Pro Val Ala Asp Pro Asn Ala 
            500                 505                 510         


Ser Ser Gly Ala Tyr Tyr Ser Pro Arg Lys Gln Gly Ala Gly Leu Val 
        515                 520                 525             


Asn Val Gln Ala Ala Thr Thr Ser Ser Val Tyr Pro Thr Val Asn Gly 
    530                 535                 540                 


Ala Ala Asp Ser Ser Arg Pro Lys Ala Glu Leu Gly Asp Gly Thr Lys 
545                 550                 555                 560 


Gly Trp His Phe Asp Val Thr Leu His Asn Met Ser Gly Thr Ala Ala 
                565                 570                 575     


Thr Tyr Asp Leu Ser Ala Gln Ala Leu Ser Glu Asn Ile Ser Gly Gly 
            580                 585                 590         


Leu Phe Thr Gly Ser Ser Thr Asp Trp Asn Gly Lys Gly Val Ser Val 
        595                 600                 605             


Ser Phe Ser Asn Asn Ser Val Thr Val Pro Ala Lys Gly Glu Ala Thr 
    610                 615                 620                 


Val Gly Ile Asp Val Thr Pro Gly Ser Gln Phe Ala Gln Trp Val Ser 
625                 630                 635                 640 


Ala Asn Ala Pro Ser Gly Thr Phe Leu Asp Gly Phe Val Arg Phe Thr 
                645                 650                 655     


Ala Arg Thr Asn Gly Gln Ser Asp Met Thr Val Pro Tyr Leu Gly Phe 
            660                 665                 670         


Tyr Gly Ser Trp Gly Thr Pro Ser Ile Phe Asp Gln Met Leu Ser Glu 
        675                 680                 685             


Gly Asp Gly His Ala Ala Ser Ser Ala Ile Tyr Asn Gly Gln Asn Gly 
    690                 695                 700                 


Ser Leu Leu Gly Tyr Asn Pro Leu Val Lys Gly Ser Glu Arg Glu Gly 
705                 710                 715                 720 


Arg Pro Asn Ala Asp Arg Tyr Val Ile Ser Arg Ser Thr Ala Ser Gly 
                725                 730                 735     


Ala Pro Thr Ala Ile Thr Pro Arg Thr Gly Thr Leu Arg Ser Val His 
            740                 745                 750         


Thr Met Thr Thr Thr Tyr Ala Asn Glu Ala Gly Lys Ser Val Ala Ser 
        755                 760                 765             


Phe Thr Ser Thr Gln Asn Trp Lys Ser Val Tyr Asn Ser Asp Glu Arg 
    770                 775                 780                 


Arg Met Thr Trp Val Glu Glu Asn His Glu Ser Arg Ser Ile Asn Leu 
785                 790                 795                 800 


Asn Asp Tyr Lys Tyr Ser Arg Leu Pro Asp Gly Lys Tyr Thr Leu Thr 
                805                 810                 815     


Ile Ser Ala Ser Asn Asp Gly Pro Ser Pro Thr Lys Gln Ser Leu Thr 
            820                 825                 830         


Tyr Asn Phe Arg Val Asp Thr Lys Ala Pro Val Val Glu Arg Ala Thr 
        835                 840                 845             


Leu Ser Asn Gly Gly Ser Thr Leu Asn Val Glu Ile Ser Asp Glu Ser 
    850                 855                 860                 


Pro Leu Ala Gly Phe Thr Val Asn Asp Pro Asn Ser Gly Gln Tyr Ile 
865                 870                 875                 880 


Tyr Arg Asp Val Ile Arg Asn Asp Ala Asp Gln Thr Tyr Ser Asn Gly 
                885                 890                 895     


Arg Tyr His Tyr Thr Ala Thr Val Asp Met Ser Arg Val Ser Gly Gly 
            900                 905                 910         


Asn Ser Ser Lys Pro Tyr Val Leu Ala Trp Asp Tyr Gly Leu Asn His 
        915                 920                 925             


Ser Lys Ala Thr Thr Ile Gly Ala Ala Thr Gly Asn Gly Gly Gly Asn 
    930                 935                 940                 


Asp Gly Gly Asn Thr Gly Asp Gln Pro Gly Asn Gly Gly Gly Asp Asn 
945                 950                 955                 960 


Gly Gly Asn Thr Gly Asp Gln Pro Gly Asn Gly Gly Gly Asn Asp Gly 
                965                 970                 975     


Gly Asn Thr Gly Asp Gln Pro Gly Asn Gly Gly Gly Asp Gly Gly Gly 
            980                 985                 990         


Ile Gly Gly Asn Val Cys Ser Pro  Ser Met Gly Gly Arg  Trp Val Thr 
        995                 1000                 1005             


Asp Gly  Tyr Arg Trp Ala Trp  Gln Cys Asn Asn Gly  Ala Tyr Leu 
    1010                 1015                 1020             


Arg Asn  Gly Trp Tyr Leu Ile  Asp Gly Arg Tyr Tyr  Tyr Phe Asp 
    1025                 1030                 1035             


Gly Asn  Gly Tyr Met Arg Ser  Gly Trp Val Arg Gly  Arg Gly Ser 
    1040                 1045                 1050             


Trp Tyr  Tyr Leu Gly Asn Asn  Gly Ala Met Gln Thr  Gly Trp Val 
    1055                 1060                 1065             


Lys Ile  Gly Gly Arg Trp Tyr  Tyr Leu Gly Ser Asp  Gly Ala Met 
    1070                 1075                 1080             


Tyr Ser  Gly Thr Arg Thr Ile  Asp Gly Asn Ser Tyr  Glu Phe Ser 
    1085                 1090                 1095             


Glu Ser  Gly Glu Trp Ile Lys  
    1100                 1105 


<210>  31
<211>  1195
<212>  PRT
<213>  Actinomyces georgiae

<400>  31

Met Pro Thr Arg Arg Thr Asn Ala Leu Ala Ser Leu Ile Ala Ser Ser 
1               5                   10                  15      


Ser Leu Leu Leu Ala Ser Ala Val Ala Leu Pro Ala Gln Ala Phe Ser 
            20                  25                  30          


Pro Pro Gly Glu Asp Asp Gln Gly Arg Gly Ser Pro Ala Thr Ser Gln 
        35                  40                  45              


Ala Ala Ala Asp Thr Ala Leu Thr Ser Lys Ala Asp Tyr Glu Asn Gly 
    50                  55                  60                  


Thr Gly Pro Gly Pro Val Asp Asp Thr Gln Ser Asp Ala Ala Glu Pro 
65                  70                  75                  80  


Asp Gly Thr Gly Gly His Ala Pro Asp Glu Gly Val Arg Ile Ile Val 
                85                  90                  95      


Gln Phe Glu Asp Gly Val Ser Glu Ser Asp Cys Asp Glu Met Val Asp 
            100                 105                 110         


Arg Ile Gly Glu Ala Val Ala Ala Ser Val Pro Ser Ala Ala Ala Gly 
        115                 120                 125             


Gly Pro Ala Val Thr Arg Ala Arg Asp Tyr Arg Asn Val Phe Ile Gly 
    130                 135                 140                 


Val Ala Ile Asp Ala Pro Ala Ala Ala Leu Pro Val Ile Gln Gly Val 
145                 150                 155                 160 


Asp Gly Met Lys Ser Ala Phe Ile Glu Arg Glu Gly His Ile Glu Thr 
                165                 170                 175     


Asp Glu Ser Glu Gln Pro Gly Gly Pro Ser Gly Asn Ser Ser Pro Ala 
            180                 185                 190         


His Glu Ala Gly Ala Ala Gly Ser Gly Ser Ala Ser Ala Ala Gly Ser 
        195                 200                 205             


Pro Ser Pro Ala Asp Ala Pro Ser Pro Ala Asp Thr Pro Ser Ser Gly 
    210                 215                 220                 


Gly Ala Ala Ser Asn Gly Asp Asp Ala Pro Ser Gly Ala Pro Ala Ser 
225                 230                 235                 240 


Gly Ala Ala Pro Ser Gln Asp Pro Ala Ala Asp Ser Gly Asn Val Glu 
                245                 250                 255     


Gly Thr Ala Gly Ser Leu Ala Ala Glu Gly Ile Asp Pro Ser Asn Arg 
            260                 265                 270         


Ser Ala His Gln Met Met Arg Met Asp Arg Val Pro His Lys Gly Glu 
        275                 280                 285             


Gly Arg Val Ile Ala Phe Leu Asp Thr Gly Leu Glu Val Ala His Pro 
    290                 295                 300                 


Ala Phe Ser Gly Ala Val Asp Ala Ser Lys Thr Ala Leu Lys Arg Ala 
305                 310                 315                 320 


Asp Val Glu Gln Ala Leu Pro Arg Leu Gly Glu Gly Lys Asp Gly Arg 
                325                 330                 335     


Tyr Val Asn Asp Lys Ile Pro Phe Ala Tyr Asp Tyr Ala Asp Asp Asp 
            340                 345                 350         


Ala Asp Val Ala Pro Ser Ser Gly Ala Gly Gly Phe His Gly Thr His 
        355                 360                 365             


Val Ala Gly Ile Ala Ala Ala Asn Ala Asp Arg Ile Arg Gly Thr Ala 
    370                 375                 380                 


Ser Gly Ala Gln Ile Ile Val Ala Lys Val Ala Arg Ser Gly Asn Gly 
385                 390                 395                 400 


Ser Leu Pro Asp Ser Ala Val Leu Ala Ala Leu Asp Asp Met Ala Val 
                405                 410                 415     


Leu Arg Pro Asp Val Ile Asn Leu Ser Ile Gly Trp Ser Ala Gly Met 
            420                 425                 430         


Asp Asn Ala Ala Asp Ser Leu Tyr Ser Thr Val Tyr Ala Arg Leu Gln 
        435                 440                 445             


Glu Ala Gly Val Thr Val Asp Ala Ala Ala Gly Asn Ala Tyr Ser Ala 
    450                 455                 460                 


Gly Arg Gly Asn Asn Ser Gly Lys Asn Leu Pro Tyr Ala Ser Asp Pro 
465                 470                 475                 480 


Asp Ser Ser Val Met Asp Glu Pro Ala Thr Tyr Ser Ser Ala Val Ala 
                485                 490                 495     


Val Ala Ser Val Asp Asn Ala Pro Ala Asn Gly Ala Tyr Lys Ala Ser 
            500                 505                 510         


Asp Phe Ser Ala Trp Gly Val Ser Pro Asp Leu Arg Leu Lys Pro Glu 
        515                 520                 525             


Ile Ala Ser Pro Gly Gly Gly Val Val Ser Ala Val Pro Gly Gly Ala 
    530                 535                 540                 


Tyr Asp Gln Ala Ser Gly Thr Ser Met Ala Thr Pro Gln Met Ala Gly 
545                 550                 555                 560 


Ile Ser Ala Ile Val Leu Glu Arg Val Asn Thr Asp Pro Leu Phe Ala 
                565                 570                 575     


Ser Met Ser Ala Ala Glu Arg Met Gly Val Ala Gln Ser Leu Ile Met 
            580                 585                 590         


Gly Thr Ala His Pro Leu Val Asp Ala Asp Gln Gly Thr Gly Ala Phe 
        595                 600                 605             


Tyr Ser Pro Arg Lys Gln Gly Ala Gly Leu Val Asp Ala Leu Ala Ala 
    610                 615                 620                 


Thr Thr Ser Pro Val Tyr Pro Thr Val Asp Gly Ala Ala Glu Pro Ser 
625                 630                 635                 640 


Arg Pro Lys Ala Asp Leu Gly Asp Gly Thr Ala Gly Trp Ser Phe Thr 
                645                 650                 655     


Ile Thr Val His Asn Leu Ser Asp Ser Ala Lys Ser Tyr Ala Leu Ser 
            660                 665                 670         


Ser Gln Ala Leu Ser Glu Ala Val Glu Gly Gly Phe Phe Thr Leu Arg 
        675                 680                 685             


Ser Lys Asp Trp Arg Gly Arg Gly Ile Ser Val Ser Tyr Ser Gly Ala 
    690                 695                 700                 


Ala Val Ala Gly Ser Gly Glu Gly Ala Thr Leu Ala Val Pro Ala Ser 
705                 710                 715                 720 


Gly Gln Ala Ser Val Thr Val Ser Val Ser Pro Gly Ala Asp Phe Ala 
                725                 730                 735     


Ser Tyr Ala Ala Ala Asn Ala Pro Lys Gly Thr Phe Ile Asp Gly Phe 
            740                 745                 750         


Val Arg Leu Val Ala Gln Gly Gly Ser Gly Pro Asp Leu Ser Val Pro 
        755                 760                 765             


Tyr Leu Gly Phe Tyr Gly Ser Trp Gly Ala Ala Asp Val Phe Asp Ala 
    770                 775                 780                 


Lys Ala Ser Asp Ala Ala Ala Ser Pro Ala His Ile Tyr Pro Ser Ala 
785                 790                 795                 800 


Phe Val Asp Ser Arg Thr Gly Arg Ser Leu Gly Ala Asn Pro Phe Ala 
                805                 810                 815     


Pro Gln Asn Thr Glu Thr Ile Pro Asp Pro Gly Arg Tyr Val Val Ser 
            820                 825                 830         


Arg Ala Ala Ser Ser Leu Ala Thr Arg Arg Ala Glu Pro Arg Thr Gly 
        835                 840                 845             


Leu Leu Arg Ser Val His Thr Leu Thr Ser Thr Tyr Ala Asn Glu Ala 
    850                 855                 860                 


Gly Thr Thr Val Leu Glu Tyr Arg Asn Tyr Gln Asn Tyr Lys Ser Val 
865                 870                 875                 880 


Arg Asn Ala Asn Gly Thr Val Ser Arg Ala Glu Ser Tyr His Leu Ala 
                885                 890                 895     


Pro Val Phe Asp Ser Glu Asp Lys Gln Val Ala Gly Leu Pro Asp Gly 
            900                 905                 910         


Lys Tyr Thr Leu Thr Ile Ala Ala Thr Thr Ser Gly Pro Ser Pro Thr 
        915                 920                 925             


Arg His Ala Ile Ala Tyr Asp Phe Ala Leu Asp Thr Thr Ala Pro Arg 
    930                 935                 940                 


Val Thr Val Arg Gly Val Ser Gly Glu Gly Ala Gly Ala Lys Val Ala 
945                 950                 955                 960 


Phe Asp Val Thr Asp Ala Ser Pro Leu Ala Ala Phe Asp Phe His Asp 
                965                 970                 975     


Pro Ser Asn Gly Thr Trp Tyr Tyr Arg Glu Leu Val Asn Asp Asp Gly 
            980                 985                 990         


Thr Val Asn Pro Asp Gly Ser His  Thr Tyr His Phe Glu  Val Ser Ala 
        995                 1000                 1005             


Ser Ala  Leu Gln Ala Ala Trp  Glu Ala Gln His Gly  Lys Gly Ala 
    1010                 1015                 1020             


Ala Pro  Ser Glu Pro Tyr Val  Leu Ala Trp Asp Trp  Gly Ala Asn 
    1025                 1030                 1035             


Pro Ser  Asp Lys Ala Val Val  Arg Phe Pro Gly Thr  Thr Ser Gly 
    1040                 1045                 1050             


Ala Trp  Thr His Asp Ser His  Gly Trp Trp Tyr Arg  Leu Ser Asp 
    1055                 1060                 1065             


Gly Ser  Trp Pro Ser Ser Thr  Ser Met Val Ile Asp  Gly Ala Thr 
    1070                 1075                 1080             


Tyr Arg  Phe Asp Ala Ser Gly  Tyr Met Arg Thr Gly  Trp Val Ser 
    1085                 1090                 1095             


Glu Ala  Gly Ser Trp Tyr Tyr  His Leu Pro Ser Gly  Ala Met Ala 
    1100                 1105                 1110             


Lys Gly  Trp Ala Asn Val Gly  Gly Thr Trp Tyr Tyr  Leu Ser Ser 
    1115                 1120                 1125             


Gly Thr  Gly Ala Met Ala Thr  Gly Trp Leu Asn Gln  Gly Gly Thr 
    1130                 1135                 1140             


Trp Tyr  Tyr Leu Ala Ala Ser  Gly Ala Met Ala Thr  Gly Trp Ala 
    1145                 1150                 1155             


Asp Val  Gly Gly Thr Trp Tyr  Tyr Phe Ser Ser Ser  Gly Ala Met 
    1160                 1165                 1170             


Ala Thr  Gly Trp Lys Trp Ile  Asp Gly Ala Trp Tyr  Gln Phe Ser 
    1175                 1180                 1185             


Ser Ser  Gly Ala Trp Thr Gly  
    1190                 1195 


<210>  32
<211>  1163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Actinomyces georgiae F0490 protease

<400>  32

Pro Pro Gly Glu Asp Asp Gln Gly Arg Gly Ser Pro Ala Thr Ser Gln 
1               5                   10                  15      


Ala Ala Ala Asp Thr Ala Leu Thr Ser Lys Ala Asp Tyr Glu Asn Gly 
            20                  25                  30          


Thr Gly Pro Gly Pro Val Asp Asp Thr Gln Ser Asp Ala Ala Glu Pro 
        35                  40                  45              


Asp Gly Thr Gly Gly His Ala Pro Asp Glu Gly Val Arg Ile Ile Val 
    50                  55                  60                  


Gln Phe Glu Asp Gly Val Ser Glu Ser Asp Cys Asp Glu Met Val Asp 
65                  70                  75                  80  


Arg Ile Gly Glu Ala Val Ala Ala Ser Val Pro Ser Ala Ala Ala Gly 
                85                  90                  95      


Gly Pro Ala Val Thr Arg Ala Arg Asp Tyr Arg Asn Val Phe Ile Gly 
            100                 105                 110         


Val Ala Ile Asp Ala Pro Ala Ala Ala Leu Pro Val Ile Gln Gly Val 
        115                 120                 125             


Asp Gly Met Lys Ser Ala Phe Ile Glu Arg Glu Gly His Ile Glu Thr 
    130                 135                 140                 


Asp Glu Ser Glu Gln Pro Gly Gly Pro Ser Gly Asn Ser Ser Pro Ala 
145                 150                 155                 160 


His Glu Ala Gly Ala Ala Gly Ser Gly Ser Ala Ser Ala Ala Gly Ser 
                165                 170                 175     


Pro Ser Pro Ala Asp Ala Pro Ser Pro Ala Asp Thr Pro Ser Ser Gly 
            180                 185                 190         


Gly Ala Ala Ser Asn Gly Asp Asp Ala Pro Ser Gly Ala Pro Ala Ser 
        195                 200                 205             


Gly Ala Ala Pro Ser Gln Asp Pro Ala Ala Asp Ser Gly Asn Val Glu 
    210                 215                 220                 


Gly Thr Ala Gly Ser Leu Ala Ala Glu Gly Ile Asp Pro Ser Asn Arg 
225                 230                 235                 240 


Ser Ala His Gln Met Met Arg Met Asp Arg Val Pro His Lys Gly Glu 
                245                 250                 255     


Gly Arg Val Ile Ala Phe Leu Asp Thr Gly Leu Glu Val Ala His Pro 
            260                 265                 270         


Ala Phe Ser Gly Ala Val Asp Ala Ser Lys Thr Ala Leu Lys Arg Ala 
        275                 280                 285             


Asp Val Glu Gln Ala Leu Pro Arg Leu Gly Glu Gly Lys Asp Gly Arg 
    290                 295                 300                 


Tyr Val Asn Asp Lys Ile Pro Phe Ala Tyr Asp Tyr Ala Asp Asp Asp 
305                 310                 315                 320 


Ala Asp Val Ala Pro Ser Ser Gly Ala Gly Gly Phe His Gly Thr His 
                325                 330                 335     


Val Ala Gly Ile Ala Ala Ala Asn Ala Asp Arg Ile Arg Gly Thr Ala 
            340                 345                 350         


Ser Gly Ala Gln Ile Ile Val Ala Lys Val Ala Arg Ser Gly Asn Gly 
        355                 360                 365             


Ser Leu Pro Asp Ser Ala Val Leu Ala Ala Leu Asp Asp Met Ala Val 
    370                 375                 380                 


Leu Arg Pro Asp Val Ile Asn Leu Ser Ile Gly Trp Ser Ala Gly Met 
385                 390                 395                 400 


Asp Asn Ala Ala Asp Ser Leu Tyr Ser Thr Val Tyr Ala Arg Leu Gln 
                405                 410                 415     


Glu Ala Gly Val Thr Val Asp Ala Ala Ala Gly Asn Ala Tyr Ser Ala 
            420                 425                 430         


Gly Arg Gly Asn Asn Ser Gly Lys Asn Leu Pro Tyr Ala Ser Asp Pro 
        435                 440                 445             


Asp Ser Ser Val Met Asp Glu Pro Ala Thr Tyr Ser Ser Ala Val Ala 
    450                 455                 460                 


Val Ala Ser Val Asp Asn Ala Pro Ala Asn Gly Ala Tyr Lys Ala Ser 
465                 470                 475                 480 


Asp Phe Ser Ala Trp Gly Val Ser Pro Asp Leu Arg Leu Lys Pro Glu 
                485                 490                 495     


Ile Ala Ser Pro Gly Gly Gly Val Val Ser Ala Val Pro Gly Gly Ala 
            500                 505                 510         


Tyr Asp Gln Ala Ser Gly Thr Ser Met Ala Thr Pro Gln Met Ala Gly 
        515                 520                 525             


Ile Ser Ala Ile Val Leu Glu Arg Val Asn Thr Asp Pro Leu Phe Ala 
    530                 535                 540                 


Ser Met Ser Ala Ala Glu Arg Met Gly Val Ala Gln Ser Leu Ile Met 
545                 550                 555                 560 


Gly Thr Ala His Pro Leu Val Asp Ala Asp Gln Gly Thr Gly Ala Phe 
                565                 570                 575     


Tyr Ser Pro Arg Lys Gln Gly Ala Gly Leu Val Asp Ala Leu Ala Ala 
            580                 585                 590         


Thr Thr Ser Pro Val Tyr Pro Thr Val Asp Gly Ala Ala Glu Pro Ser 
        595                 600                 605             


Arg Pro Lys Ala Asp Leu Gly Asp Gly Thr Ala Gly Trp Ser Phe Thr 
    610                 615                 620                 


Ile Thr Val His Asn Leu Ser Asp Ser Ala Lys Ser Tyr Ala Leu Ser 
625                 630                 635                 640 


Ser Gln Ala Leu Ser Glu Ala Val Glu Gly Gly Phe Phe Thr Leu Arg 
                645                 650                 655     


Ser Lys Asp Trp Arg Gly Arg Gly Ile Ser Val Ser Tyr Ser Gly Ala 
            660                 665                 670         


Ala Val Ala Gly Ser Gly Glu Gly Ala Thr Leu Ala Val Pro Ala Ser 
        675                 680                 685             


Gly Gln Ala Ser Val Thr Val Ser Val Ser Pro Gly Ala Asp Phe Ala 
    690                 695                 700                 


Ser Tyr Ala Ala Ala Asn Ala Pro Lys Gly Thr Phe Ile Asp Gly Phe 
705                 710                 715                 720 


Val Arg Leu Val Ala Gln Gly Gly Ser Gly Pro Asp Leu Ser Val Pro 
                725                 730                 735     


Tyr Leu Gly Phe Tyr Gly Ser Trp Gly Ala Ala Asp Val Phe Asp Ala 
            740                 745                 750         


Lys Ala Ser Asp Ala Ala Ala Ser Pro Ala His Ile Tyr Pro Ser Ala 
        755                 760                 765             


Phe Val Asp Ser Arg Thr Gly Arg Ser Leu Gly Ala Asn Pro Phe Ala 
    770                 775                 780                 


Pro Gln Asn Thr Glu Thr Ile Pro Asp Pro Gly Arg Tyr Val Val Ser 
785                 790                 795                 800 


Arg Ala Ala Ser Ser Leu Ala Thr Arg Arg Ala Glu Pro Arg Thr Gly 
                805                 810                 815     


Leu Leu Arg Ser Val His Thr Leu Thr Ser Thr Tyr Ala Asn Glu Ala 
            820                 825                 830         


Gly Thr Thr Val Leu Glu Tyr Arg Asn Tyr Gln Asn Tyr Lys Ser Val 
        835                 840                 845             


Arg Asn Ala Asn Gly Thr Val Ser Arg Ala Glu Ser Tyr His Leu Ala 
    850                 855                 860                 


Pro Val Phe Asp Ser Glu Asp Lys Gln Val Ala Gly Leu Pro Asp Gly 
865                 870                 875                 880 


Lys Tyr Thr Leu Thr Ile Ala Ala Thr Thr Ser Gly Pro Ser Pro Thr 
                885                 890                 895     


Arg His Ala Ile Ala Tyr Asp Phe Ala Leu Asp Thr Thr Ala Pro Arg 
            900                 905                 910         


Val Thr Val Arg Gly Val Ser Gly Glu Gly Ala Gly Ala Lys Val Ala 
        915                 920                 925             


Phe Asp Val Thr Asp Ala Ser Pro Leu Ala Ala Phe Asp Phe His Asp 
    930                 935                 940                 


Pro Ser Asn Gly Thr Trp Tyr Tyr Arg Glu Leu Val Asn Asp Asp Gly 
945                 950                 955                 960 


Thr Val Asn Pro Asp Gly Ser His Thr Tyr His Phe Glu Val Ser Ala 
                965                 970                 975     


Ser Ala Leu Gln Ala Ala Trp Glu Ala Gln His Gly Lys Gly Ala Ala 
            980                 985                 990         


Pro Ser Glu Pro Tyr Val Leu Ala  Trp Asp Trp Gly Ala  Asn Pro Ser 
        995                 1000                 1005             


Asp Lys  Ala Val Val Arg Phe  Pro Gly Thr Thr Ser  Gly Ala Trp 
    1010                 1015                 1020             


Thr His  Asp Ser His Gly Trp  Trp Tyr Arg Leu Ser  Asp Gly Ser 
    1025                 1030                 1035             


Trp Pro  Ser Ser Thr Ser Met  Val Ile Asp Gly Ala  Thr Tyr Arg 
    1040                 1045                 1050             


Phe Asp  Ala Ser Gly Tyr Met  Arg Thr Gly Trp Val  Ser Glu Ala 
    1055                 1060                 1065             


Gly Ser  Trp Tyr Tyr His Leu  Pro Ser Gly Ala Met  Ala Lys Gly 
    1070                 1075                 1080             


Trp Ala  Asn Val Gly Gly Thr  Trp Tyr Tyr Leu Ser  Ser Gly Thr 
    1085                 1090                 1095             


Gly Ala  Met Ala Thr Gly Trp  Leu Asn Gln Gly Gly  Thr Trp Tyr 
    1100                 1105                 1110             


Tyr Leu  Ala Ala Ser Gly Ala  Met Ala Thr Gly Trp  Ala Asp Val 
    1115                 1120                 1125             


Gly Gly  Thr Trp Tyr Tyr Phe  Ser Ser Ser Gly Ala  Met Ala Thr 
    1130                 1135                 1140             


Gly Trp  Lys Trp Ile Asp Gly  Ala Trp Tyr Gln Phe  Ser Ser Ser 
    1145                 1150                 1155             


Gly Ala  Trp Thr Gly 
    1160             


<210>  33
<211>  1236
<212>  PRT
<213>  Actinomyces sp. oral taxon 877 str. F0543

<400>  33

Met Pro Thr Arg Arg Thr Asn Ala Leu Ala Ala Leu Leu Ala Ser Ser 
1               5                   10                  15      


Ser Leu Leu Leu Ala Ser Ala Val Ala Leu Pro Ala Gln Ser Phe Pro 
            20                  25                  30          


Pro Pro Gly Gly Asp Asp Gln Gly Gln Gly Ser Pro Ala Thr Ser Gln 
        35                  40                  45              


Ala Ala Ala Asp Thr Ala Leu Thr Ser Lys Ala Asp Tyr Glu Asn Gly 
    50                  55                  60                  


Ala Gly Pro Gly Pro Ala Asp Glu Ala His Pro Tyr Gly Ala Gln Ser 
65                  70                  75                  80  


Asp Ala Ser Gln Pro Asp Ala Pro Gln Ser Asp Ala Ser Gln Pro Asp 
                85                  90                  95      


Gly Ala Glu Gly His Ala Pro Glu Glu Gly Val Arg Ile Ile Val Gln 
            100                 105                 110         


Phe Ala Asp Glu Ala Ser Glu Ser Asp Cys Asp Glu Leu Val Asp Arg 
        115                 120                 125             


Ile Gly Glu Ala Val Ala Ala Ser Val Pro Ala Ala Ala Gly Gly Pro 
    130                 135                 140                 


Ala Ile Thr Arg Ala Arg Asp Tyr Arg Asn Val Phe Thr Gly Val Ala 
145                 150                 155                 160 


Ile Asp Ala Pro Ala Ala Ser Leu Pro Val Val Gln Gly Val Asp Gly 
                165                 170                 175     


Val Lys Ser Ala Phe Ile Glu Arg Glu Gly His Ile Glu Gly Asp Glu 
            180                 185                 190         


Ser Glu Gln Pro Gly Gly Pro Ser Gly Asn Gly Gly Pro Ala His Glu 
        195                 200                 205             


Ala Gly Ala Asp Gly Ser Gly Ser Ala Ser Ala Ala His Ser Pro Ser 
    210                 215                 220                 


Pro Ala His Ser Pro Ser Pro Ala Gly Ile Pro Pro Ser Gly Asp Ala 
225                 230                 235                 240 


Ala Ser Asn Gly Asp Gly Ala Pro Ser Gly Ala Pro Ala Ser Gly Ala 
                245                 250                 255     


Ser Pro Ser Pro Ala Ala Thr Pro Ser Gln Asp Ala Ala Ala Gly Ser 
            260                 265                 270         


Gly Asn Val Glu Gly Gly Ala Asp Ser Leu Ala Ala Glu Gly Ile Asp 
        275                 280                 285             


Pro Ser Asn Arg Ser Ala His Leu Met Met Arg Met Asp His Val Ser 
    290                 295                 300                 


His Lys Gly Glu Gly Arg Val Ile Ala Phe Leu Asp Thr Gly Leu Glu 
305                 310                 315                 320 


Val Ala His Pro Ala Phe Ser Gly Ala Val Asp Ala Ser Lys Thr Ala 
                325                 330                 335     


Leu Lys Arg Ala Asp Val Glu Gln Val Leu Pro Arg Leu Gly Glu Gly 
            340                 345                 350         


Lys Asp Gly His Tyr Val Asn Asp Lys Ile Pro Phe Val Tyr Asp Tyr 
        355                 360                 365             


Ala Asp Asp Asp Ala Asp Val Ala Pro Ser Ser Gly Pro Gly Gly Phe 
    370                 375                 380                 


His Gly Thr His Val Ala Gly Ile Ala Ala Ala Asn Ala Asp Arg Ile 
385                 390                 395                 400 


Arg Gly Thr Ala Pro Gly Ala Gln Ile Ile Val Ala Lys Val Ala Arg 
                405                 410                 415     


Ser Gly Asn Gly Ser Leu Pro Asp Ser Ala Val Leu Ala Ala Leu Asp 
            420                 425                 430         


Asp Met Ala Val Leu Arg Pro Asp Val Val Asn Leu Ser Ile Gly Trp 
        435                 440                 445             


Ser Ala Gly Met Asp Asn Ala Ala Asp Ser Leu Tyr Ser Thr Val Tyr 
    450                 455                 460                 


Ala Ser Leu Gln Gly Ala Gly Val Thr Val Asn Ala Ala Ala Gly Asn 
465                 470                 475                 480 


Ser Tyr Ser Ala Gly Arg Gly Asn Arg Ser Gly Lys Asn Leu Pro Tyr 
                485                 490                 495     


Ala Ser Asp Pro Asp Ser Ser Val Met Asp Glu Pro Ala Thr Tyr Ser 
            500                 505                 510         


Ser Ala Val Ala Val Ala Ser Val Asp Asn Ala Pro Ala Asn Gly Ala 
        515                 520                 525             


Tyr Arg Ala Ser Asp Phe Ser Ala Trp Gly Val Ser Pro Asp Leu Arg 
    530                 535                 540                 


Leu Lys Pro Glu Ile Ala Ser Pro Gly Gly Gly Val Val Ser Ala Val 
545                 550                 555                 560 


Pro Gly Gly Ala Tyr Asp Gln Ala Ser Gly Thr Ser Met Ala Thr Pro 
                565                 570                 575     


Gln Met Ala Gly Ile Ser Ala Ile Val Leu Glu Arg Val Ser Thr Asp 
            580                 585                 590         


Pro Leu Phe Ala Gly Met Ser Ala Ala Glu Arg Thr Gly Val Ala Gln 
        595                 600                 605             


Ser Leu Ile Met Gly Thr Ala His Pro Leu Val Asp Ala Asp Gln Gly 
    610                 615                 620                 


Thr Gly Ala Phe Tyr Ser Pro Arg Lys Gln Gly Ala Gly Leu Val Asp 
625                 630                 635                 640 


Ala Leu Ala Ala Thr Thr Ser Pro Val Tyr Pro Thr Val Asp Gly Ala 
                645                 650                 655     


Ala Glu Pro Ser Arg Pro Lys Ala Asp Leu Gly Asp Gly Thr Ala Gly 
            660                 665                 670         


Trp Ser Phe Thr Ile Thr Val His Asn Leu Ser Asp Ser Ala Lys Ser 
        675                 680                 685             


Tyr Ala Leu Ser Ser Gln Ala Leu Ser Glu Ala Val Glu Gly Gly Phe 
    690                 695                 700                 


Phe Thr Leu His Ser Thr Asp Trp Arg Gly Arg Gly Val Ser Val Ser 
705                 710                 715                 720 


Tyr Ser Gly Ala Ala Val Ala Gly Ser Gly Glu Gly Ala Ala Leu Thr 
                725                 730                 735     


Val Pro Ala Ser Gly Arg Ala Ser Val Thr Val Ser Val Ala Pro Gly 
            740                 745                 750         


Ala Ala Phe Ala Ser Tyr Ala Asn Ala Asn Ala Pro Lys Gly Thr Phe 
        755                 760                 765             


Ile Asp Gly Phe Val Arg Leu Ala Ala Gln Asn Gly Ser Gly Pro Asp 
    770                 775                 780                 


Leu Ser Val Pro Tyr Leu Gly Phe Tyr Gly Ser Trp Gly Ala Ala Asp 
785                 790                 795                 800 


Val Phe Asp Ala Lys Ala Ser Asp Ala Ala Val Ser Pro Ala His Ile 
                805                 810                 815     


Tyr Pro Ser Ala Phe Val Asp Ser Arg Thr Gly Arg Pro Leu Gly Ala 
            820                 825                 830         


Asn Pro Leu Ala Pro Arg Asn Thr Glu Thr Val Pro Asp Pro Gly Arg 
        835                 840                 845             


Tyr Val Val Ser Arg Ala Ala Ser Ser Leu Ala Thr Arg Arg Ala Glu 
    850                 855                 860                 


Pro Arg Thr Gly Leu Leu Arg Ser Val His Thr Leu Thr Ser Thr Tyr 
865                 870                 875                 880 


Ala Asn Glu Ala Gly Ala Thr Val Arg Glu Tyr Thr Asn Tyr Gln Asn 
                885                 890                 895     


Tyr Lys Ser Val Arg Asn Ala Asn Gly Thr Val Ser Arg Ala Glu Ser 
            900                 905                 910         


Tyr His Leu Ala Pro Val Phe Asp Ser Glu Asp Gln Val Gly Ala Gly 
        915                 920                 925             


Leu Pro Asp Gly Lys Tyr Thr Leu Thr Ile Ala Ala Thr Thr Ser Gly 
    930                 935                 940                 


Pro Ser Pro Thr Arg His Ala Ile Ser Tyr Asp Phe Ala Leu Asp Thr 
945                 950                 955                 960 


Thr Ala Pro Arg Val Thr Val Arg Gly Val Ile Gly Glu Gly Ala Gly 
                965                 970                 975     


Ala Lys Val Ala Phe Asp Val Thr Asp Ala Ser Pro Leu Ala Ala Phe 
            980                 985                 990         


Asp Phe His Asp Pro Ser Asn Gly  Thr Trp Tyr Tyr Arg  Glu Leu Val 
        995                 1000                 1005             


Asn Asp  Asp Gly Thr Val Asn  Pro Asp Gly Ser His  Thr Tyr His 
    1010                 1015                 1020             


Phe Glu  Val Ser Ala Ser Ala  Leu Gln Ala Ala Trp  Glu Ala Gln 
    1025                 1030                 1035             


Arg Gly  Lys Gly Ala Ala Pro  Ser Gln Pro Tyr Val  Leu Ala Trp 
    1040                 1045                 1050             


Asp Trp  Gly Val Asn Pro Ser  Asp Lys Thr Val Val  Arg Phe Pro 
    1055                 1060                 1065             


Gly Thr  Thr Ser Gly Ala Trp  Thr His Asp Ser His  Gly Trp Trp 
    1070                 1075                 1080             


Tyr Arg  Leu Pro Asp Gly Ser  Trp Pro Ser Ser Thr  Ser Met Val 
    1085                 1090                 1095             


Ile Asp  Gly Glu Thr Tyr Arg  Phe Asp Ala Ser Gly  Tyr Met Arg 
    1100                 1105                 1110             


Thr Gly  Trp Val Gly Glu Ala  Gly Ser Trp Tyr Tyr  His Leu Pro 
    1115                 1120                 1125             


Ser Gly  Ala Met Ala Lys Gly  Trp Ala His Asp Ser  Gly Ser Trp 
    1130                 1135                 1140             


Tyr Tyr  Leu Ser Pro Gly Thr  Gly Ala Met Ala Thr  Gly Trp Ile 
    1145                 1150                 1155             


Glu Gln  Gly Gly Thr Trp Tyr  Tyr Leu Ser Pro Gly  Thr Gly Ala 
    1160                 1165                 1170             


Met Ala  Thr Gly Trp Thr Asn  Val Gly Gly Thr Trp  Tyr Tyr Phe 
    1175                 1180                 1185             


Ser Ser  Ser Gly Ala Met Ala  Thr Gly Trp Leu Lys  Val Gly Gly 
    1190                 1195                 1200             


Thr Trp  Tyr Tyr Leu Ala Pro  Ser Gly Ala Met Ala  Thr Gly Trp 
    1205                 1210                 1215             


Thr Asn  Ile Asp Gly Thr Trp  Tyr Tyr Phe Ser Ser  Ser Gly Ala 
    1220                 1225                 1230             


Trp Thr  Gly 
    1235     


<210>  34
<211>  1204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Actinomyces sp. oral taxon 877 str. F0543

<400>  34

Pro Pro Gly Gly Asp Asp Gln Gly Gln Gly Ser Pro Ala Thr Ser Gln 
1               5                   10                  15      


Ala Ala Ala Asp Thr Ala Leu Thr Ser Lys Ala Asp Tyr Glu Asn Gly 
            20                  25                  30          


Ala Gly Pro Gly Pro Ala Asp Glu Ala His Pro Tyr Gly Ala Gln Ser 
        35                  40                  45              


Asp Ala Ser Gln Pro Asp Ala Pro Gln Ser Asp Ala Ser Gln Pro Asp 
    50                  55                  60                  


Gly Ala Glu Gly His Ala Pro Glu Glu Gly Val Arg Ile Ile Val Gln 
65                  70                  75                  80  


Phe Ala Asp Glu Ala Ser Glu Ser Asp Cys Asp Glu Leu Val Asp Arg 
                85                  90                  95      


Ile Gly Glu Ala Val Ala Ala Ser Val Pro Ala Ala Ala Gly Gly Pro 
            100                 105                 110         


Ala Ile Thr Arg Ala Arg Asp Tyr Arg Asn Val Phe Thr Gly Val Ala 
        115                 120                 125             


Ile Asp Ala Pro Ala Ala Ser Leu Pro Val Val Gln Gly Val Asp Gly 
    130                 135                 140                 


Val Lys Ser Ala Phe Ile Glu Arg Glu Gly His Ile Glu Gly Asp Glu 
145                 150                 155                 160 


Ser Glu Gln Pro Gly Gly Pro Ser Gly Asn Gly Gly Pro Ala His Glu 
                165                 170                 175     


Ala Gly Ala Asp Gly Ser Gly Ser Ala Ser Ala Ala His Ser Pro Ser 
            180                 185                 190         


Pro Ala His Ser Pro Ser Pro Ala Gly Ile Pro Pro Ser Gly Asp Ala 
        195                 200                 205             


Ala Ser Asn Gly Asp Gly Ala Pro Ser Gly Ala Pro Ala Ser Gly Ala 
    210                 215                 220                 


Ser Pro Ser Pro Ala Ala Thr Pro Ser Gln Asp Ala Ala Ala Gly Ser 
225                 230                 235                 240 


Gly Asn Val Glu Gly Gly Ala Asp Ser Leu Ala Ala Glu Gly Ile Asp 
                245                 250                 255     


Pro Ser Asn Arg Ser Ala His Leu Met Met Arg Met Asp His Val Ser 
            260                 265                 270         


His Lys Gly Glu Gly Arg Val Ile Ala Phe Leu Asp Thr Gly Leu Glu 
        275                 280                 285             


Val Ala His Pro Ala Phe Ser Gly Ala Val Asp Ala Ser Lys Thr Ala 
    290                 295                 300                 


Leu Lys Arg Ala Asp Val Glu Gln Val Leu Pro Arg Leu Gly Glu Gly 
305                 310                 315                 320 


Lys Asp Gly His Tyr Val Asn Asp Lys Ile Pro Phe Val Tyr Asp Tyr 
                325                 330                 335     


Ala Asp Asp Asp Ala Asp Val Ala Pro Ser Ser Gly Pro Gly Gly Phe 
            340                 345                 350         


His Gly Thr His Val Ala Gly Ile Ala Ala Ala Asn Ala Asp Arg Ile 
        355                 360                 365             


Arg Gly Thr Ala Pro Gly Ala Gln Ile Ile Val Ala Lys Val Ala Arg 
    370                 375                 380                 


Ser Gly Asn Gly Ser Leu Pro Asp Ser Ala Val Leu Ala Ala Leu Asp 
385                 390                 395                 400 


Asp Met Ala Val Leu Arg Pro Asp Val Val Asn Leu Ser Ile Gly Trp 
                405                 410                 415     


Ser Ala Gly Met Asp Asn Ala Ala Asp Ser Leu Tyr Ser Thr Val Tyr 
            420                 425                 430         


Ala Ser Leu Gln Gly Ala Gly Val Thr Val Asn Ala Ala Ala Gly Asn 
        435                 440                 445             


Ser Tyr Ser Ala Gly Arg Gly Asn Arg Ser Gly Lys Asn Leu Pro Tyr 
    450                 455                 460                 


Ala Ser Asp Pro Asp Ser Ser Val Met Asp Glu Pro Ala Thr Tyr Ser 
465                 470                 475                 480 


Ser Ala Val Ala Val Ala Ser Val Asp Asn Ala Pro Ala Asn Gly Ala 
                485                 490                 495     


Tyr Arg Ala Ser Asp Phe Ser Ala Trp Gly Val Ser Pro Asp Leu Arg 
            500                 505                 510         


Leu Lys Pro Glu Ile Ala Ser Pro Gly Gly Gly Val Val Ser Ala Val 
        515                 520                 525             


Pro Gly Gly Ala Tyr Asp Gln Ala Ser Gly Thr Ser Met Ala Thr Pro 
    530                 535                 540                 


Gln Met Ala Gly Ile Ser Ala Ile Val Leu Glu Arg Val Ser Thr Asp 
545                 550                 555                 560 


Pro Leu Phe Ala Gly Met Ser Ala Ala Glu Arg Thr Gly Val Ala Gln 
                565                 570                 575     


Ser Leu Ile Met Gly Thr Ala His Pro Leu Val Asp Ala Asp Gln Gly 
            580                 585                 590         


Thr Gly Ala Phe Tyr Ser Pro Arg Lys Gln Gly Ala Gly Leu Val Asp 
        595                 600                 605             


Ala Leu Ala Ala Thr Thr Ser Pro Val Tyr Pro Thr Val Asp Gly Ala 
    610                 615                 620                 


Ala Glu Pro Ser Arg Pro Lys Ala Asp Leu Gly Asp Gly Thr Ala Gly 
625                 630                 635                 640 


Trp Ser Phe Thr Ile Thr Val His Asn Leu Ser Asp Ser Ala Lys Ser 
                645                 650                 655     


Tyr Ala Leu Ser Ser Gln Ala Leu Ser Glu Ala Val Glu Gly Gly Phe 
            660                 665                 670         


Phe Thr Leu His Ser Thr Asp Trp Arg Gly Arg Gly Val Ser Val Ser 
        675                 680                 685             


Tyr Ser Gly Ala Ala Val Ala Gly Ser Gly Glu Gly Ala Ala Leu Thr 
    690                 695                 700                 


Val Pro Ala Ser Gly Arg Ala Ser Val Thr Val Ser Val Ala Pro Gly 
705                 710                 715                 720 


Ala Ala Phe Ala Ser Tyr Ala Asn Ala Asn Ala Pro Lys Gly Thr Phe 
                725                 730                 735     


Ile Asp Gly Phe Val Arg Leu Ala Ala Gln Asn Gly Ser Gly Pro Asp 
            740                 745                 750         


Leu Ser Val Pro Tyr Leu Gly Phe Tyr Gly Ser Trp Gly Ala Ala Asp 
        755                 760                 765             


Val Phe Asp Ala Lys Ala Ser Asp Ala Ala Val Ser Pro Ala His Ile 
    770                 775                 780                 


Tyr Pro Ser Ala Phe Val Asp Ser Arg Thr Gly Arg Pro Leu Gly Ala 
785                 790                 795                 800 


Asn Pro Leu Ala Pro Arg Asn Thr Glu Thr Val Pro Asp Pro Gly Arg 
                805                 810                 815     


Tyr Val Val Ser Arg Ala Ala Ser Ser Leu Ala Thr Arg Arg Ala Glu 
            820                 825                 830         


Pro Arg Thr Gly Leu Leu Arg Ser Val His Thr Leu Thr Ser Thr Tyr 
        835                 840                 845             


Ala Asn Glu Ala Gly Ala Thr Val Arg Glu Tyr Thr Asn Tyr Gln Asn 
    850                 855                 860                 


Tyr Lys Ser Val Arg Asn Ala Asn Gly Thr Val Ser Arg Ala Glu Ser 
865                 870                 875                 880 


Tyr His Leu Ala Pro Val Phe Asp Ser Glu Asp Gln Val Gly Ala Gly 
                885                 890                 895     


Leu Pro Asp Gly Lys Tyr Thr Leu Thr Ile Ala Ala Thr Thr Ser Gly 
            900                 905                 910         


Pro Ser Pro Thr Arg His Ala Ile Ser Tyr Asp Phe Ala Leu Asp Thr 
        915                 920                 925             


Thr Ala Pro Arg Val Thr Val Arg Gly Val Ile Gly Glu Gly Ala Gly 
    930                 935                 940                 


Ala Lys Val Ala Phe Asp Val Thr Asp Ala Ser Pro Leu Ala Ala Phe 
945                 950                 955                 960 


Asp Phe His Asp Pro Ser Asn Gly Thr Trp Tyr Tyr Arg Glu Leu Val 
                965                 970                 975     


Asn Asp Asp Gly Thr Val Asn Pro Asp Gly Ser His Thr Tyr His Phe 
            980                 985                 990         


Glu Val Ser Ala Ser Ala Leu Gln  Ala Ala Trp Glu Ala  Gln Arg Gly 
        995                 1000                 1005             


Lys Gly  Ala Ala Pro Ser Gln  Pro Tyr Val Leu Ala  Trp Asp Trp 
    1010                 1015                 1020             


Gly Val  Asn Pro Ser Asp Lys  Thr Val Val Arg Phe  Pro Gly Thr 
    1025                 1030                 1035             


Thr Ser  Gly Ala Trp Thr His  Asp Ser His Gly Trp  Trp Tyr Arg 
    1040                 1045                 1050             


Leu Pro  Asp Gly Ser Trp Pro  Ser Ser Thr Ser Met  Val Ile Asp 
    1055                 1060                 1065             


Gly Glu  Thr Tyr Arg Phe Asp  Ala Ser Gly Tyr Met  Arg Thr Gly 
    1070                 1075                 1080             


Trp Val  Gly Glu Ala Gly Ser  Trp Tyr Tyr His Leu  Pro Ser Gly 
    1085                 1090                 1095             


Ala Met  Ala Lys Gly Trp Ala  His Asp Ser Gly Ser  Trp Tyr Tyr 
    1100                 1105                 1110             


Leu Ser  Pro Gly Thr Gly Ala  Met Ala Thr Gly Trp  Ile Glu Gln 
    1115                 1120                 1125             


Gly Gly  Thr Trp Tyr Tyr Leu  Ser Pro Gly Thr Gly  Ala Met Ala 
    1130                 1135                 1140             


Thr Gly  Trp Thr Asn Val Gly  Gly Thr Trp Tyr Tyr  Phe Ser Ser 
    1145                 1150                 1155             


Ser Gly  Ala Met Ala Thr Gly  Trp Leu Lys Val Gly  Gly Thr Trp 
    1160                 1165                 1170             


Tyr Tyr  Leu Ala Pro Ser Gly  Ala Met Ala Thr Gly  Trp Thr Asn 
    1175                 1180                 1185             


Ile Asp  Gly Thr Trp Tyr Tyr  Phe Ser Ser Ser Gly  Ala Trp Thr 
    1190                 1195                 1200             


Gly 
    


<210>  35
<211>  1157
<212>  PRT
<213>  Actinomyces sp. ICM47

<400>  35

Met Thr Leu Lys Lys Pro Ala Lys Leu Ile Ala Ile Ala Gly Ala Cys 
1               5                   10                  15      


Ala Val Ala Val Ala Leu Pro Thr Ser Leu Ala Leu Pro Gly Ser Phe 
            20                  25                  30          


Gly Pro Glu Ala Asp Ser Asp Pro Glu Ala Ala Gln Ser Ala Ala Gly 
        35                  40                  45              


Val Val Ala Gln Pro Glu Pro Glu Pro Glu Leu Pro Val Gly Asn Ala 
    50                  55                  60                  


Glu Asn Ala Leu Thr Ser Glu Glu Gly Glu Gln Val Val Asp Gly Glu 
65                  70                  75                  80  


Thr Gln Ala Ser Thr Asp Asp Gly Ser Ser Arg Val Val Asp Met Ile 
                85                  90                  95      


Val Gln Leu Lys Asp Gly Thr Asp Thr Ala Ala Ala Leu Ala Ser Ile 
            100                 105                 110         


Asn Ser Ala Val Ala Ala Ala Tyr Pro Asp Ala Ser Ala Glu Val Lys 
        115                 120                 125             


Arg Glu Tyr Ser Asn Thr Phe Thr Gly Phe Ala Leu Ser Ala Pro Ile 
    130                 135                 140                 


Gly Ser Met Asp Ala Ile Arg Gly Val Ser Gly Val Gln Ser Ala Phe 
145                 150                 155                 160 


Leu Asp Arg Glu Thr Gln Val Ser Asp Asp Ala Asn Gly Asp Ser Asp 
                165                 170                 175     


Asp Ala Gly Ser Gly Ser Ala Thr Thr Ala Ser Arg Ser Gln His Pro 
            180                 185                 190         


Asp Asn Leu Ser Ala Gln Ile Met Met His Ala Asp Lys Val Thr Gln 
        195                 200                 205             


Lys Gly Glu Gly Lys Val Val Ala Ile Ile Asp Thr Gly Val Glu Met 
    210                 215                 220                 


Asn His Pro Ala Phe Ser Gly Ala Leu His Gly Thr Pro Ala Ile Asp 
225                 230                 235                 240 


Ser Ser Lys Gly Ala Ser Leu Ala Gln Gln Val Gly Lys Ser Gly Thr 
                245                 250                 255     


Tyr Val Ser Glu Lys Phe Pro Phe Ala Tyr Asp Tyr Ala Asp Gly Asp 
            260                 265                 270         


Asn Asp Ala Ser Pro Ala Gly Ala His Gly Thr His Val Ala Gly Ile 
        275                 280                 285             


Thr Ala Ala Asn Gly Asp Gln Ile Met Gly Ile Ala Pro Asp Ala Gln 
    290                 295                 300                 


Ile Ile Val Ala Lys Val Ala Arg Ser Arg Gly Gly Gly Ile Pro Asp 
305                 310                 315                 320 


Ser Ala Leu Leu Ala Ala Leu Asp Asp Met Ala Thr Leu His Pro Asp 
                325                 330                 335     


Ala Val Asn Met Ser Leu Gly Arg Thr Ala Gly Met Asp Ser Asp Ala 
            340                 345                 350         


Asp Thr Leu Phe Ala Gly Val Tyr Glu Lys Leu Gln Glu Lys Gly Ile 
        355                 360                 365             


Thr Leu Asp Val Ala Gly Gly Asn Glu Phe Gln Ala Gly Tyr Gly Asn 
    370                 375                 380                 


Lys Ser Gly Lys Asn Leu Pro Tyr Ala Ser Asp Pro Asp Ser Ser Thr 
385                 390                 395                 400 


Leu Gly Glu Pro Gly Ser Phe Ala Pro Val Val Thr Val Ala Ser Ile 
                405                 410                 415     


Glu Asn Ala Arg Asn Gly Ala Asn Gly Asn Tyr Lys Met Ser Asp Phe 
            420                 425                 430         


Ser Ser Trp Gly Val Ser Pro Asp Met Arg Leu Lys Pro Glu Val Thr 
        435                 440                 445             


Ala Pro Gly Gly Asn Ile Tyr Ser Ser Val Pro Gly Gly Gly Tyr Gln 
    450                 455                 460                 


Met Met Ser Gly Thr Ser Met Ala Thr Pro Gln Met Thr Gly Ala Ser 
465                 470                 475                 480 


Ala Val Val Leu Glu Arg Val Gln Asn Asp Pro Leu Phe Ser Ser Leu 
                485                 490                 495     


Asn Asp Arg Gln Lys Val Asp Val Val Gln Asn Leu Ile Met Gly Thr 
            500                 505                 510         


Ala Val Pro Val Val Asp Pro Gly Gln Gly Gly Gly Ala Tyr Tyr Ser 
        515                 520                 525             


Pro Arg Lys Gln Gly Ala Gly Leu Ala Asn Leu Glu Gly Ala Thr Thr 
    530                 535                 540                 


Ser Ser Val Tyr Pro Thr Val Asn Gly Ala Ala Asp Ser Ser Arg Pro 
545                 550                 555                 560 


Lys Ala Glu Leu Gly Asp Gly Thr Asn Gly Trp His Phe Asp Val Thr 
                565                 570                 575     


Leu His Asn Val Ser Asp Thr Pro Ala Thr Tyr Glu Leu Ser Ser Gln 
            580                 585                 590         


Ala Leu Ser Glu Asn Ile Glu Gly Gly Phe Phe Thr Gly His Ser Thr 
        595                 600                 605             


Asp Trp Asn Gly Lys Gly Val Ser Val Ser Phe Ser Gly Ser Ser Val 
    610                 615                 620                 


Thr Val Pro Ala Lys Gly Glu Thr Thr Val Gly Ile Asp Ile Lys Pro 
625                 630                 635                 640 


Gly Asn Glu Phe Ala Gln Tyr Val Ser Ala Asn Ala Pro Ala Gly Thr 
                645                 650                 655     


Phe Leu Asp Gly Phe Val Arg Phe Thr Ser Arg Thr Asn Gly Gln Pro 
            660                 665                 670         


Asp Leu Gly Val Pro Phe Leu Gly Phe Tyr Gly Ser Trp Ala Lys Pro 
        675                 680                 685             


Ala Ile Phe Asp Ala Leu Val Ser Glu Gly Asp Ala His Ala Ala Ser 
    690                 695                 700                 


Ser Gly Ile Tyr Asn Gly Asp Arg Gly Gly Leu Leu Gly Tyr Asn Pro 
705                 710                 715                 720 


Leu Leu Lys Gly Arg Glu Arg Gln Gly Arg Pro Asn Ala Glu Arg Tyr 
                725                 730                 735     


Val Val Ser Arg Ser Thr Val Ser Gly Ala Pro Thr Ala Ile Ser Pro 
            740                 745                 750         


Arg Thr Gly Thr Leu Arg Ser Val His Lys Met Thr Thr Thr Tyr Thr 
        755                 760                 765             


Asn Glu Ala Gly Lys Ser Val Ala Ser Phe Thr Ser Phe Gln Asn Phe 
    770                 775                 780                 


Lys Ser Thr Ile Asp Pro Glu Glu Glu Arg Met Ser Trp Val Glu Glu 
785                 790                 795                 800 


Gly Gln Glu Pro Arg Ser Ile Asp Leu Lys Glu Gly Lys Tyr Ala Ser 
                805                 810                 815     


Leu Pro Asp Gly Asn Tyr Lys Leu Thr Ile Ala Ala Asn Asn Asp Gly 
            820                 825                 830         


Pro Ser Ser Thr Glu Gln Ser Ile Thr Tyr Asn Phe Arg Ile Asp Thr 
        835                 840                 845             


Lys Ala Pro Val Val Asp Ser Ala Lys Val Asn Gly Ser Thr Leu Ser 
    850                 855                 860                 


Val Glu Leu Ser Asp Glu Ser Pro Leu Ala Gly Phe Thr Leu Asn Asp 
865                 870                 875                 880 


Pro Asn Ser Gly Arg Tyr Ile His Leu Glu Val Ala Arg Asp Glu Asn 
                885                 890                 895     


Ser Gln Thr Tyr Glu Asn Gly Arg Tyr His Tyr Lys Thr Ser Ile Asp 
            900                 905                 910         


Leu Asn Gln Val Gln Gly Gly Ala Ser Asn Asn Pro Tyr Val Val Ala 
        915                 920                 925             


Trp Asp Tyr Gly Leu Asn His Ser Glu Pro Val Thr Met Asn Gly Gly 
    930                 935                 940                 


Lys Pro Gly Asn Gly Gly Gly Gln Pro Gly Val Gly Asp Asp Gln Pro 
945                 950                 955                 960 


Gly Asn Gly Gly Gly Gln Pro Gly Val Gly Asp Asp Gln Pro Gly Asn 
                965                 970                 975     


Gly Gly Gly Gln Pro Gly Asn Gly Gly Gly Gln Pro Gly Asp Asp Trp 
            980                 985                 990         


Gly Asp Asp Gln Pro Gly Asn Gly  Gly Gly Gln Pro Gly  Asp Asp Trp 
        995                 1000                 1005             


Gly Asn  Gly Gly Gly Gln Pro  Gly Asp Asp Trp Gly  Asn Gly Gly 
    1010                 1015                 1020             


Gly Gln  Pro Gly Asn Gly Gly  Gly Gln Pro Gly Asp  Gly Trp Asp 
    1025                 1030                 1035             


Asn Gly  Gly Gly Gln Pro Gly  Gly Gly Trp Asp Asn  Gly Gly Gly 
    1040                 1045                 1050             


Gln Pro  Gly Gly Asn Pro Gly  Asn Gly Gly Asn Ser  Gly Tyr Cys 
    1055                 1060                 1065             


Asp Phe  Leu Asn Gly Tyr Trp  Leu Ser Asp Pro Val  Gly Trp Trp 
    1070                 1075                 1080             


Gln Lys  Cys Val Ser Gly Lys  Ser Leu Pro Arg Asn  Gln Trp Ser 
    1085                 1090                 1095             


Asn Ile  Gly Gly Lys Asp Tyr  Phe Val Gly Pro Asp  Gly Asn Ala 
    1100                 1105                 1110             


Gln Thr  Gly Trp Leu Asn Gln  Gly Asp Thr Trp Tyr  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Ser  Asn Gly Gly Ser Met  Cys Thr Gly Thr Arg  Asn Ile Asp 
    1130                 1135                 1140             


Gly Lys  Thr Tyr Thr Phe Asp  Asn Ser Gly Ala Leu  Val Lys 
    1145                 1150                 1155         


<210>  36
<211>  1129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Actinomyces sp. ICM47 protease

<400>  36

Pro Gly Ser Phe Gly Pro Glu Ala Asp Ser Asp Pro Glu Ala Ala Gln 
1               5                   10                  15      


Ser Ala Ala Gly Val Val Ala Gln Pro Glu Pro Glu Pro Glu Leu Pro 
            20                  25                  30          


Val Gly Asn Ala Glu Asn Ala Leu Thr Ser Glu Glu Gly Glu Gln Val 
        35                  40                  45              


Val Asp Gly Glu Thr Gln Ala Ser Thr Asp Asp Gly Ser Ser Arg Val 
    50                  55                  60                  


Val Asp Met Ile Val Gln Leu Lys Asp Gly Thr Asp Thr Ala Ala Ala 
65                  70                  75                  80  


Leu Ala Ser Ile Asn Ser Ala Val Ala Ala Ala Tyr Pro Asp Ala Ser 
                85                  90                  95      


Ala Glu Val Lys Arg Glu Tyr Ser Asn Thr Phe Thr Gly Phe Ala Leu 
            100                 105                 110         


Ser Ala Pro Ile Gly Ser Met Asp Ala Ile Arg Gly Val Ser Gly Val 
        115                 120                 125             


Gln Ser Ala Phe Leu Asp Arg Glu Thr Gln Val Ser Asp Asp Ala Asn 
    130                 135                 140                 


Gly Asp Ser Asp Asp Ala Gly Ser Gly Ser Ala Thr Thr Ala Ser Arg 
145                 150                 155                 160 


Ser Gln His Pro Asp Asn Leu Ser Ala Gln Ile Met Met His Ala Asp 
                165                 170                 175     


Lys Val Thr Gln Lys Gly Glu Gly Lys Val Val Ala Ile Ile Asp Thr 
            180                 185                 190         


Gly Val Glu Met Asn His Pro Ala Phe Ser Gly Ala Leu His Gly Thr 
        195                 200                 205             


Pro Ala Ile Asp Ser Ser Lys Gly Ala Ser Leu Ala Gln Gln Val Gly 
    210                 215                 220                 


Lys Ser Gly Thr Tyr Val Ser Glu Lys Phe Pro Phe Ala Tyr Asp Tyr 
225                 230                 235                 240 


Ala Asp Gly Asp Asn Asp Ala Ser Pro Ala Gly Ala His Gly Thr His 
                245                 250                 255     


Val Ala Gly Ile Thr Ala Ala Asn Gly Asp Gln Ile Met Gly Ile Ala 
            260                 265                 270         


Pro Asp Ala Gln Ile Ile Val Ala Lys Val Ala Arg Ser Arg Gly Gly 
        275                 280                 285             


Gly Ile Pro Asp Ser Ala Leu Leu Ala Ala Leu Asp Asp Met Ala Thr 
    290                 295                 300                 


Leu His Pro Asp Ala Val Asn Met Ser Leu Gly Arg Thr Ala Gly Met 
305                 310                 315                 320 


Asp Ser Asp Ala Asp Thr Leu Phe Ala Gly Val Tyr Glu Lys Leu Gln 
                325                 330                 335     


Glu Lys Gly Ile Thr Leu Asp Val Ala Gly Gly Asn Glu Phe Gln Ala 
            340                 345                 350         


Gly Tyr Gly Asn Lys Ser Gly Lys Asn Leu Pro Tyr Ala Ser Asp Pro 
        355                 360                 365             


Asp Ser Ser Thr Leu Gly Glu Pro Gly Ser Phe Ala Pro Val Val Thr 
    370                 375                 380                 


Val Ala Ser Ile Glu Asn Ala Arg Asn Gly Ala Asn Gly Asn Tyr Lys 
385                 390                 395                 400 


Met Ser Asp Phe Ser Ser Trp Gly Val Ser Pro Asp Met Arg Leu Lys 
                405                 410                 415     


Pro Glu Val Thr Ala Pro Gly Gly Asn Ile Tyr Ser Ser Val Pro Gly 
            420                 425                 430         


Gly Gly Tyr Gln Met Met Ser Gly Thr Ser Met Ala Thr Pro Gln Met 
        435                 440                 445             


Thr Gly Ala Ser Ala Val Val Leu Glu Arg Val Gln Asn Asp Pro Leu 
    450                 455                 460                 


Phe Ser Ser Leu Asn Asp Arg Gln Lys Val Asp Val Val Gln Asn Leu 
465                 470                 475                 480 


Ile Met Gly Thr Ala Val Pro Val Val Asp Pro Gly Gln Gly Gly Gly 
                485                 490                 495     


Ala Tyr Tyr Ser Pro Arg Lys Gln Gly Ala Gly Leu Ala Asn Leu Glu 
            500                 505                 510         


Gly Ala Thr Thr Ser Ser Val Tyr Pro Thr Val Asn Gly Ala Ala Asp 
        515                 520                 525             


Ser Ser Arg Pro Lys Ala Glu Leu Gly Asp Gly Thr Asn Gly Trp His 
    530                 535                 540                 


Phe Asp Val Thr Leu His Asn Val Ser Asp Thr Pro Ala Thr Tyr Glu 
545                 550                 555                 560 


Leu Ser Ser Gln Ala Leu Ser Glu Asn Ile Glu Gly Gly Phe Phe Thr 
                565                 570                 575     


Gly His Ser Thr Asp Trp Asn Gly Lys Gly Val Ser Val Ser Phe Ser 
            580                 585                 590         


Gly Ser Ser Val Thr Val Pro Ala Lys Gly Glu Thr Thr Val Gly Ile 
        595                 600                 605             


Asp Ile Lys Pro Gly Asn Glu Phe Ala Gln Tyr Val Ser Ala Asn Ala 
    610                 615                 620                 


Pro Ala Gly Thr Phe Leu Asp Gly Phe Val Arg Phe Thr Ser Arg Thr 
625                 630                 635                 640 


Asn Gly Gln Pro Asp Leu Gly Val Pro Phe Leu Gly Phe Tyr Gly Ser 
                645                 650                 655     


Trp Ala Lys Pro Ala Ile Phe Asp Ala Leu Val Ser Glu Gly Asp Ala 
            660                 665                 670         


His Ala Ala Ser Ser Gly Ile Tyr Asn Gly Asp Arg Gly Gly Leu Leu 
        675                 680                 685             


Gly Tyr Asn Pro Leu Leu Lys Gly Arg Glu Arg Gln Gly Arg Pro Asn 
    690                 695                 700                 


Ala Glu Arg Tyr Val Val Ser Arg Ser Thr Val Ser Gly Ala Pro Thr 
705                 710                 715                 720 


Ala Ile Ser Pro Arg Thr Gly Thr Leu Arg Ser Val His Lys Met Thr 
                725                 730                 735     


Thr Thr Tyr Thr Asn Glu Ala Gly Lys Ser Val Ala Ser Phe Thr Ser 
            740                 745                 750         


Phe Gln Asn Phe Lys Ser Thr Ile Asp Pro Glu Glu Glu Arg Met Ser 
        755                 760                 765             


Trp Val Glu Glu Gly Gln Glu Pro Arg Ser Ile Asp Leu Lys Glu Gly 
    770                 775                 780                 


Lys Tyr Ala Ser Leu Pro Asp Gly Asn Tyr Lys Leu Thr Ile Ala Ala 
785                 790                 795                 800 


Asn Asn Asp Gly Pro Ser Ser Thr Glu Gln Ser Ile Thr Tyr Asn Phe 
                805                 810                 815     


Arg Ile Asp Thr Lys Ala Pro Val Val Asp Ser Ala Lys Val Asn Gly 
            820                 825                 830         


Ser Thr Leu Ser Val Glu Leu Ser Asp Glu Ser Pro Leu Ala Gly Phe 
        835                 840                 845             


Thr Leu Asn Asp Pro Asn Ser Gly Arg Tyr Ile His Leu Glu Val Ala 
    850                 855                 860                 


Arg Asp Glu Asn Ser Gln Thr Tyr Glu Asn Gly Arg Tyr His Tyr Lys 
865                 870                 875                 880 


Thr Ser Ile Asp Leu Asn Gln Val Gln Gly Gly Ala Ser Asn Asn Pro 
                885                 890                 895     


Tyr Val Val Ala Trp Asp Tyr Gly Leu Asn His Ser Glu Pro Val Thr 
            900                 905                 910         


Met Asn Gly Gly Lys Pro Gly Asn Gly Gly Gly Gln Pro Gly Val Gly 
        915                 920                 925             


Asp Asp Gln Pro Gly Asn Gly Gly Gly Gln Pro Gly Val Gly Asp Asp 
    930                 935                 940                 


Gln Pro Gly Asn Gly Gly Gly Gln Pro Gly Asn Gly Gly Gly Gln Pro 
945                 950                 955                 960 


Gly Asp Asp Trp Gly Asp Asp Gln Pro Gly Asn Gly Gly Gly Gln Pro 
                965                 970                 975     


Gly Asp Asp Trp Gly Asn Gly Gly Gly Gln Pro Gly Asp Asp Trp Gly 
            980                 985                 990         


Asn Gly Gly Gly Gln Pro Gly Asn  Gly Gly Gly Gln Pro  Gly Asp Gly 
        995                 1000                 1005             


Trp Asp  Asn Gly Gly Gly Gln  Pro Gly Gly Gly Trp  Asp Asn Gly 
    1010                 1015                 1020             


Gly Gly  Gln Pro Gly Gly Asn  Pro Gly Asn Gly Gly  Asn Ser Gly 
    1025                 1030                 1035             


Tyr Cys  Asp Phe Leu Asn Gly  Tyr Trp Leu Ser Asp  Pro Val Gly 
    1040                 1045                 1050             


Trp Trp  Gln Lys Cys Val Ser  Gly Lys Ser Leu Pro  Arg Asn Gln 
    1055                 1060                 1065             


Trp Ser  Asn Ile Gly Gly Lys  Asp Tyr Phe Val Gly  Pro Asp Gly 
    1070                 1075                 1080             


Asn Ala  Gln Thr Gly Trp Leu  Asn Gln Gly Asp Thr  Trp Tyr Tyr 
    1085                 1090                 1095             


Leu Asp  Pro Ser Asn Gly Gly  Ser Met Cys Thr Gly  Thr Arg Asn 
    1100                 1105                 1110             


Ile Asp  Gly Lys Thr Tyr Thr  Phe Asp Asn Ser Gly  Ala Leu Val 
    1115                 1120                 1125             


Lys 
    


<210>  37
<211>  1627
<212>  PRT
<213>  Lactobacillus acidophilus

<400>  37

Met Arg Asn Lys Lys Val Gly Ser Val Thr Thr Asp Tyr Ser Tyr Leu 
1               5                   10                  15      


Asn Gln Ser Arg Asn His Leu Asn Leu Val Thr Gly Lys Glu Asn Asp 
            20                  25                  30          


Ser Lys Leu Lys Ile Trp Arg Lys Asn Phe Ala Thr Ala Ala Ile Ile 
        35                  40                  45              


Ala Leu Ala Ser Gly Thr Thr Met Leu Phe Ser Ala His Ser Val Lys 
    50                  55                  60                  


Ala Asp Glu Val Asp Asp Ile Thr Val Gln Asn Asp Lys Gln Val Asn 
65                  70                  75                  80  


Thr Thr Ile Val Gln Asn Asn Lys Asp Gln Gln Ser Ser Asp Thr Gln 
                85                  90                  95      


Gln Asn Val Asn Glu Asn Arg Ala Ser Ser Gln Gln Ala Ile Arg Arg 
            100                 105                 110         


Pro Gly Thr Gly Asn Lys Leu Thr Asp Gln Trp Pro Asp Asn Tyr Gln 
        115                 120                 125             


Ser Asp Gln Gln Asn Asn Ser Ser Gln Ala Glu Thr Thr Lys Ile Ser 
    130                 135                 140                 


Thr Thr Gly Tyr Ser Asn Gln Thr Glu Gln Gln Ser Asn Asn Thr Val 
145                 150                 155                 160 


Pro Ser Thr Val Ala Ser Ser Thr Val Tyr Lys Glu Ser Ser Asp Asp 
                165                 170                 175     


Gln Ala Gly Gln Lys Asp Thr Asn Gly Val Glu Leu Pro Ala Asn Asn 
            180                 185                 190         


Gln Asp His Ile Lys Gly Asn Val Gln Asp Ala Trp Asp Gln Gly Tyr 
        195                 200                 205             


Lys Gly Gln His Thr Val Val Ala Val Ile Asp Ser Gly Val Asp Thr 
    210                 215                 220                 


Ser His Lys Asp Phe Gln Thr Met Pro Glu Asn Pro Lys Leu Ser Gln 
225                 230                 235                 240 


Ala Glu Ile Glu Ala Leu Ile Ala Lys Leu Gly Tyr Gly Thr Tyr Ile 
                245                 250                 255     


Asn Ser Lys Phe Pro Phe Val Tyr Asn Ala Val Asp His Glu Asn Gln 
            260                 265                 270         


Ser Met Lys Gly Pro Asp Gly Glu Pro His Gly Gln His Val Ser Gly 
        275                 280                 285             


Ile Ile Ala Ala Asp Gly Gln Pro Asn Gly Asp Gln Glu Tyr Val Val 
    290                 295                 300                 


Gly Val Ala Pro Glu Ala Gln Leu Met His Phe Lys Val Phe Gly Asp 
305                 310                 315                 320 


Asn Ala Thr Ser Leu Asp Leu Ala Gln Glu Ile Tyr Asp Ala Thr Asn 
                325                 330                 335     


Leu Gly Ala Asp Val Ile Gln Met Ser Leu Gly Gly Gly Val Ala Ala 
            340                 345                 350         


Ala Asp Leu Asn Val Ala Asp Gln Arg Ala Val Gln Tyr Ala Ile Asp 
        355                 360                 365             


His Gly Val Ile Val Ser Ile Ser Ala Ser Asn Asn Gly Asn Ala Ala 
    370                 375                 380                 


Ser Ile Gln Asn Pro Ser Asn Val Thr Asp Leu Asp Asn Tyr Glu Ala 
385                 390                 395                 400 


Gly Thr His Val Gly Asn Tyr Glu Pro Phe Ser Ser Ser Thr Val Ala 
                405                 410                 415     


Asp Pro Gly Ala Ala Arg Gly Ala Ile Thr Gly Ala Ala Glu Thr Ser 
            420                 425                 430         


Gly Leu Gly Asp Lys Ser Asp Met Ala Thr Phe Thr Ser Trp Gly Pro 
        435                 440                 445             


Leu Pro Asp Phe Thr Leu Lys Pro Asp Val Ser Ala Pro Gly Ser Asn 
    450                 455                 460                 


Val Ile Ser Leu Ala Asn Asp Asn Gly Tyr Thr Thr Met Ser Gly Thr 
465                 470                 475                 480 


Ser Met Ala Gly Pro Phe Ile Ala Gly Ala Ala Ala Leu Val Arg Gln 
                485                 490                 495     


Arg Leu Gln Gln Thr Asn Pro Glu Leu Lys Gly Ala Asp Leu Val Ala 
            500                 505                 510         


Ala Val Lys Ala Leu Leu Met Asn Thr Ala Asp Pro Gln Ile Gln Gln 
        515                 520                 525             


Gly Phe Thr Thr Ile Val Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile 
    530                 535                 540                 


Asn Val Gly Ala Ala Thr Lys Ala Pro Val Tyr Ile Leu Ala Asn Asp 
545                 550                 555                 560 


Gly Thr Gly Ser Val Ser Leu Arg Asn Ile Lys Glu Thr Thr Asn Phe 
                565                 570                 575     


Glu Leu Thr Phe His Asn Leu Thr Asp Asn Thr Glu Thr Tyr Thr Phe 
            580                 585                 590         


Asp Asp Leu Gly Gly Gly Phe Thr Glu Val Arg Asp Thr Asp Thr Gly 
        595                 600                 605             


Leu Phe His Asp Val Gln Leu Ala Gly Ala Arg Val Thr Gly Pro Asn 
    610                 615                 620                 


Thr Ile Thr Val Asn Pro Lys Glu Thr Lys Lys Ile Val Phe Thr Leu 
625                 630                 635                 640 


Asn Leu Thr Gly Leu Lys Gln Asn Gln Leu Val Glu Gly Tyr Leu Asn 
                645                 650                 655     


Phe Thr Asn Ser Lys Asp Lys Leu Ser Leu Ser Val Pro Tyr Leu Gly 
            660                 665                 670         


Tyr Tyr Gly Asp Met Thr Ser Glu Asp Val Phe Asp Lys Lys Ala Asn 
        675                 680                 685             


Glu Asp Lys Pro Asp Ile Lys Gly Asn Arg Leu Thr Asn Glu Asp Asn 
    690                 695                 700                 


Tyr Pro Arg Gly Ile Ala Asp Glu Glu Ser Leu Lys Glu Leu Val Asn 
705                 710                 715                 720 


Ile Glu Gly Asn Tyr Asn Trp Gln Glu Val Ala Lys Leu Tyr Glu Ser 
                725                 730                 735     


Gly Lys Val Ala Phe Ser Pro Asn Gly Asp Asn Lys Ser Asp Leu Ile 
            740                 745                 750         


Met Pro Tyr Val Tyr Leu Lys Gln Asn Leu Gln Asp Leu Lys Val Glu 
        755                 760                 765             


Ile Leu Asp Ala Lys Gly Asn Val Val Arg Val Leu Ala Asp Ala His 
    770                 775                 780                 


Gly Val Gln Lys Ser Tyr Asn Glu Asp Gly Thr Gly Thr Val Asp Ala 
785                 790                 795                 800 


Leu Ile Ser Val Asp Ser Gly Lys Phe Asn Trp Asp Gly Lys Val Tyr 
                805                 810                 815     


Asn Tyr Lys Thr Gly Lys Met Glu Val Ala Pro Asp Gly Gln Tyr Thr 
            820                 825                 830         


Tyr Arg Phe Val Ala Thr Leu Tyr Asn Asp Gly Pro His Lys Val Gln 
        835                 840                 845             


Thr Asn Asp Thr Ser Val Ile Ile Asp Thr Thr Ala Pro Ile Leu Lys 
    850                 855                 860                 


Asp Val Glu Tyr Asp Val Thr Thr Lys Thr Ile Thr Gly Thr Tyr Ser 
865                 870                 875                 880 


Asp Ala Gly Ala Gly Phe Thr Asp Tyr Ser Tyr Ala Thr Val Thr Ile 
                885                 890                 895     


Asn Asp Arg Val Phe Gly Phe Lys Leu Asn Asp Asn Asp Asn Ser Thr 
            900                 905                 910         


Phe Asp Asn Thr Asp Lys Thr Ile Gly His Phe Ser Phe Ala Leu Thr 
        915                 920                 925             


Pro Leu Glu Gln Gln Ala Leu Thr Ala Ala His Asn Lys Val Ser Val 
    930                 935                 940                 


Cys Leu Ser Asp Val Ala Asp Asn Thr Ala Val Lys Thr Leu Asp Val 
945                 950                 955                 960 


Ala Ser Val Gly Asp Gly Asn Lys Ile Ala Ile Trp Asn Ala Val Asn 
                965                 970                 975     


Gly Val Pro Phe Asn Ser Asn Ser Gln Asp Tyr Ser Asp Lys Asn Asn 
            980                 985                 990         


Ser Tyr Leu Leu Arg Gly Ser Ala  Thr Glu Asn Phe Tyr  Val Asn Gly 
        995                 1000                 1005             


Lys Leu  Val Gln Val Ala Pro  Asn Gly Glu Phe Val  Leu Pro Val 
    1010                 1015                 1020             


Ser Leu  Asp Glu Gln Asn Leu  Val Phe Thr Ser Asp  Glu Asn Gly 
    1025                 1030                 1035             


Gln Asn  Val Leu Arg Gln Phe  Thr Thr Tyr Thr Pro  Lys Ala Asp 
    1040                 1045                 1050             


Phe Ala  Trp Gln His Ile Asp  Gly Ser Glu Arg Ser  Phe Gly Val 
    1055                 1060                 1065             


Ser Val  Tyr Ser Ile Asp Ala  Ala Asp Pro Asn Asp  Ala Ile Val 
    1070                 1075                 1080             


Gln Ala  Ala Val Pro Lys Gly  Asn Asn Val Lys Ala  Phe Ala Lys 
    1085                 1090                 1095             


Asp Tyr  Phe Thr Gly Glu Thr  Tyr Val Gly Glu Val  Lys Asp Gly 
    1100                 1105                 1110             


Val Ala  Thr Phe His Ile His  Thr Ser Ile Asn Pro  Asp Pro Gln 
    1115                 1120                 1125             


Thr Gly  Ile Asn Arg Arg Ala  Leu Leu Gln Gly Trp  Val Glu Ile 
    1130                 1135                 1140             


Asp Gly  Pro Thr Tyr Asn Ala  Lys Gln Val Thr Asp  Pro Thr Ala 
    1145                 1150                 1155             


Ile Ser  Asp Arg Asn Tyr Ile  Gly Val Tyr Tyr Lys  Pro Asp Ala 
    1160                 1165                 1170             


Ser Ser  His Val Tyr Ser Asn  Arg Asp Glu Leu Gly  Val Asp Asp 
    1175                 1180                 1185             


Phe Thr  Asp Glu Gln Ala Asp  Val Ser Asp Phe Gly  Pro Ser Lys 
    1190                 1195                 1200             


Phe Leu  Tyr Pro Gly His Asn  Ala Pro Ser Asp Gly  Asn Ala Asn 
    1205                 1210                 1215             


Ile Ser  Phe Asp Tyr Val Asn  Asp Asn Asn Ile Ser  Thr Phe Gly 
    1220                 1225                 1230             


Gln Glu  Ala Val Lys Ala Gly  Tyr Tyr Asp Pro Ile  Ala Lys Val 
    1235                 1240                 1245             


Phe Thr  Ile Thr Gly His Val  Asp Lys Asp Val Val  Ser Leu Val 
    1250                 1255                 1260             


Ala Leu  Gln Asp Asn Pro Asn  Glu Asp Ala Pro Glu  Asn Arg Val 
    1265                 1270                 1275             


Ala Ile  Asp Lys Asp Gly Asn  Phe Ile Ile Lys Phe  His Met Asp 
    1280                 1285                 1290             


Asp Pro  Ser Thr Arg Gln Leu  Thr Tyr Ile Tyr Lys  Val Lys Asp 
    1295                 1300                 1305             


Ser Ser  Thr Asp Lys Ile Asp  Thr Val Lys Gly Ser  Ile Thr Leu 
    1310                 1315                 1320             


Ile Leu  Asp Thr Val Leu Pro  Thr Leu His Val Asp  Gln Leu Asn 
    1325                 1330                 1335             


Gly Ala  Asp Asn Leu Thr Ile  Thr Thr Asn Asn Pro  Thr Phe Lys 
    1340                 1345                 1350             


Ile Ser  Gly Asn Ala Asn Asp  Asp Leu Asp Asp Tyr  Ser Val Tyr 
    1355                 1360                 1365             


Ile Asn  Gly Asp Asn Val Phe  Thr Gln Phe Asn Gly  Ser Ser Phe 
    1370                 1375                 1380             


Asn Tyr  Ile Pro Gly Met Tyr  Gly Asp Pro Asn Gln  Lys Thr Pro 
    1385                 1390                 1395             


Asn Leu  Tyr Gly Gly Tyr Asp  Phe Glu Gln Glu Val  Asn Leu Asp 
    1400                 1405                 1410             


Asp Glu  Asn Gly Lys Pro Thr  Thr His Ile Phe Asn  Ile Glu Leu 
    1415                 1420                 1425             


Ile Asp  Gln Val Gly Asn Lys  Val Phe Lys Thr Leu  Thr Val Asn 
    1430                 1435                 1440             


Tyr Asp  Pro Asn Ala Thr Asn  Ser Glu Asp Pro Ser  Asn Gly Thr 
    1445                 1450                 1455             


Gly Asp  Ser Gly Ile Glu Val  Val Pro Thr Val Pro  Arg Lys Val 
    1460                 1465                 1470             


Gln Pro  Leu Ser Asp Asp Asn  Ser Thr Asn Ile Asn  Asp Lys Gln 
    1475                 1480                 1485             


Thr Leu  Ser Thr Glu Leu Thr  Ile Thr Leu Pro Arg  Asn Ile Phe 
    1490                 1495                 1500             


Ala Phe  Asp Tyr Gln Gly Lys  Val Ala Arg Lys His  Gly Lys Asp 
    1505                 1510                 1515             


Ile Ile  Leu Lys Lys Gly Val  Val Leu Tyr Asn Pro  Lys Glu Val 
    1520                 1525                 1530             


Asn Ile  Arg Lys His Lys Tyr  Tyr Lys Val Ser Lys  Asn Val Tyr 
    1535                 1540                 1545             


Ile Lys  Val Thr Ser Thr Arg  Val Asn Lys Lys Leu  Lys Arg Leu 
    1550                 1555                 1560             


Ile Leu  Ile Lys Asn Ser Tyr  Val Tyr Asn Leu Asn  Gly Lys Ala 
    1565                 1570                 1575             


Asn Lys  Val His Asn Lys Arg  Val Leu Leu Lys Arg  Gly Leu Ala 
    1580                 1585                 1590             


Val Asp  Val Leu His Gly Gly  Lys Ile Thr Lys Val  Gly Lys Tyr 
    1595                 1600                 1605             


Asp Cys  Tyr Gln Ile Gly Ile  Asn Gln Tyr Ile Lys  Val Ala Asn 
    1610                 1615                 1620             


Thr Ala  Leu Lys 
    1625         


<210>  38
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Lactobacillus acidophilus ATCC 4796protease

<400>  38

Asp Gly Thr Asp Thr Ala Ala Ala Leu Ala Ser Ile Asn Ser Ala Val 
1               5                   10                  15      


Ala Ala Ala Tyr Pro Asp Ala Ser Ala Glu Val Lys Arg Glu Tyr Ser 
            20                  25                  30          


Asn Thr Phe Thr Gly Phe Ala Leu Ser Ala Pro Ile Gly Ser Met Asp 
        35                  40                  45              


Ala Ile Arg Gly Val Ser Gly Val Gln Ser Ala Phe Leu Asp Arg Glu 
    50                  55                  60                  


Thr Gln Val Ser Asp Asp Ala Asn Gly Asp Ser Asp Asp Ala Gly Ser 
65                  70                  75                  80  


Gly Ser Ala Thr Thr Ala Ser Arg Ser Gln His Pro Asp Asn Leu Ser 
                85                  90                  95      


Ala Gln Ile Met Met His Ala Asp Lys Val Thr Gln Lys Gly Glu Gly 
            100                 105                 110         


Lys Val Val Ala Ile Ile Asp Thr Gly Val Glu Met Asn His Pro Ala 
        115                 120                 125             


Phe Ser Gly Ala Leu His Gly Thr Pro Ala Ile Asp Ser Ser Lys Gly 
    130                 135                 140                 


Ala Ser Leu Ala Gln Gln Val Gly Lys Ser Gly Thr Tyr Val Ser Glu 
145                 150                 155                 160 


Lys Phe Pro Phe Ala Tyr Asp Tyr Ala Asp Gly Asp Asn Asp Ala Ser 
                165                 170                 175     


Pro Ala Gly Ala His Gly Thr His Val Ala Gly Ile Thr Ala Ala Asn 
            180                 185                 190         


Gly Asp Gln Ile Met Gly Ile Ala Pro Asp Ala Gln Ile Ile Val Ala 
        195                 200                 205             


Lys Val Ala Arg Ser Arg Gly Gly Gly Ile Pro Asp Ser Ala Leu Leu 
    210                 215                 220                 


Ala Ala Leu Asp Asp Met Ala Thr Leu His Pro Asp Ala Val Asn Met 
225                 230                 235                 240 


Ser Leu Gly Arg Thr Ala Gly Met Asp Ser Asp Ala Asp Thr Leu Phe 
                245                 250                 255     


Ala Gly Val Tyr Glu Lys Leu Gln Glu Lys Gly Ile Thr Leu Asp Val 
            260                 265                 270         


Ala Gly Gly Asn Glu Phe Gln Ala Gly Tyr Gly Asn Lys Ser Gly Lys 
        275                 280                 285             


Asn Leu Pro Tyr Ala Ser Asp Pro Asp Ser Ser Thr Leu Gly Glu Pro 
    290                 295                 300                 


Gly Ser Phe Ala Pro Val Val Thr Val Ala Ser Ile Glu Asn Ala Arg 
305                 310                 315                 320 


Asn Gly Ala Asn Gly Asn Tyr Lys Met Ser Asp Phe Ser Ser Trp Gly 
                325                 330                 335     


Val Ser Pro Asp Met Arg Leu Lys Pro Glu Val Thr Ala Pro Gly Gly 
            340                 345                 350         


Asn Ile Tyr Ser Ser Val Pro Gly Gly Gly Tyr Gln Met Met Ser Gly 
        355                 360                 365             


Thr Ser Met Ala Thr Pro Gln Met Thr Gly Ala Ser Ala Val Val Leu 
    370                 375                 380                 


Glu Arg Val Gln Asn Asp Pro Leu Phe Ser Ser Leu Asn Asp Arg Gln 
385                 390                 395                 400 


Lys Val Asp Val Val Gln Asn Leu Ile Met Gly Thr Ala Val Pro Val 
                405                 410                 415     


Val Asp Pro Gly Gln Gly Gly Gly Ala Tyr Tyr Ser Pro Arg Lys Gln 
            420                 425                 430         


Gly Ala Gly Leu Ala Asn Leu Glu Gly Ala Thr Thr Ser Ser Val Tyr 
        435                 440                 445             


Pro Thr Val Asn Gly Ala Ala Asp Ser Ser Arg Pro Lys Ala Glu Leu 
    450                 455                 460                 


Gly Asp Gly Thr Asn Gly Trp His Phe Asp Val Thr Leu His Asn Val 
465                 470                 475                 480 


Ser Asp Thr Pro Ala Thr Tyr Glu Leu Ser Ser Gln Ala Leu Ser Glu 
                485                 490                 495     


Asn Ile Glu Gly Gly Phe Phe Thr Gly His Ser Thr Asp Trp Asn Gly 
            500                 505                 510         


Lys Gly Val Ser Val Ser Phe Ser Gly Ser Ser Val Thr Val Pro Ala 
        515                 520                 525             


Lys Gly Glu Thr Thr Val Gly Ile Asp Ile Lys Pro Gly Asn Glu Phe 
    530                 535                 540                 


Ala Gln Tyr Val Ser Ala Asn Ala Pro Ala Gly Thr Phe Leu Asp Gly 
545                 550                 555                 560 


Phe Val Arg Phe Thr Ser Arg Thr Asn Gly Gln Pro Asp Leu Gly Val 
                565                 570                 575     


Pro Phe Leu Gly Phe Tyr Gly Ser Trp Ala Lys Pro Ala Ile Phe Asp 
            580                 585                 590         


Ala Leu Val Ser Glu Gly Asp Ala His Ala Ala Ser Ser Gly Ile Tyr 
        595                 600                 605             


Asn Gly Asp Arg Gly Gly Leu Leu Gly Tyr Asn Pro Leu Leu Lys Gly 
    610                 615                 620                 


Arg Glu Arg Gln Gly Arg Pro Asn Ala Glu Arg Tyr Val Val Ser Arg 
625                 630                 635                 640 


Ser Thr Val Ser Gly Ala Pro Thr Ala Ile Ser Pro Arg Thr Gly Thr 
                645                 650                 655     


Leu Arg Ser Val His Lys Met Thr Thr Thr Tyr Thr Asn Glu Ala Gly 
            660                 665                 670         


Lys Ser Val Ala Ser Phe Thr Ser Phe Gln Asn Phe Lys Ser Thr Ile 
        675                 680                 685             


Asp Pro Glu Glu Glu Arg Met Ser Trp Val Glu Glu Gly Gln Glu Pro 
    690                 695                 700                 


Arg Ser Ile Asp Leu Lys Glu Gly Lys Tyr Ala Ser Leu Pro Asp Gly 
705                 710                 715                 720 


Asn Tyr Lys Leu Thr Ile Ala Ala Asn Asn Asp Gly Pro Ser Ser Thr 
                725                 730                 735     


Glu Gln Ser Ile Thr Tyr Asn Phe Arg Ile Asp Thr Lys Ala Pro Val 
            740                 745                 750         


Val Asp Ser Ala Lys Val Asn Gly Ser Thr Leu Ser Val Glu Leu Ser 
        755                 760                 765             


Asp Glu Ser Pro Leu Ala Gly Phe Thr Leu Asn Asp Pro Asn Ser Gly 
    770                 775                 780                 


Arg Tyr Ile His Leu Glu Val Ala Arg Asp Glu Asn Ser Gln Thr Tyr 
785                 790                 795                 800 


Glu Asn Gly Arg Tyr His Tyr Lys Thr Ser Ile Asp Leu Asn Gln Val 
                805                 810                 815     


Gln Gly Gly Ala Ser Asn Asn Pro Tyr Val Val Ala Trp Asp Tyr Gly 
            820                 825                 830         


Leu Asn His Ser Glu Pro Val Thr Met Asn Gly Gly Lys Pro Gly Asn 
        835                 840                 845             


Gly Gly Gly Gln Pro Gly Val Gly Asp Asp Gln Pro Gly Asn Gly Gly 
    850                 855                 860                 


Gly Gln Pro Gly Val Gly Asp Asp Gln Pro Gly Asn Gly Gly Gly Gln 
865                 870                 875                 880 


Pro Gly Asn Gly Gly Gly Gln Pro Gly Asp Asp Trp Gly Asp Asp Gln 
                885                 890                 895     


Pro Gly Asn Gly Gly Gly Gln Pro Gly Asp Asp Trp Gly Asn Gly Gly 
            900                 905                 910         


Gly Gln Pro Gly Asp Asp Trp Gly Asn Gly Gly Gly Gln Pro Gly Asn 
        915                 920                 925             


Gly Gly Gly Gln Pro Gly Asp Gly Trp Asp Asn Gly Gly Gly Gln Pro 
    930                 935                 940                 


Gly Gly Gly Trp Asp Asn Gly Gly Gly Gln Pro Gly Gly Asn Pro Gly 
945                 950                 955                 960 


Asn Gly Gly Asn Ser Gly Tyr Cys Asp Phe Leu Asn Gly Tyr Trp Leu 
                965                 970                 975     


Ser Asp Pro Val Gly Trp Trp Gln Lys Cys Val Ser Gly Lys Ser Leu 
            980                 985                 990         


Pro Arg Asn Gln Trp Ser Asn Ile  Gly Gly Lys Asp Tyr  Phe Val Gly 
        995                 1000                 1005             


Pro Asp  Gly Asn Ala Gln Thr  Gly Trp Leu Asn Gln  Gly Asp Thr 
    1010                 1015                 1020             


Trp Tyr  Tyr Leu Asp Pro Ser  Asn Gly Gly Ser Met  Cys Thr Gly 
    1025                 1030                 1035             


Thr Arg  Asn Ile Asp Gly Lys  Thr Tyr Thr Phe Asp  Asn Ser Gly 
    1040                 1045                 1050             


Ala Leu  Val Lys 
    1055         


<210>  39
<211>  1203
<212>  PRT
<213>  Lactobacillus brevis

<400>  39

Met Lys Arg Leu Cys Ile Lys Lys Gly Phe Ile Gly Val Phe Val Ser 
1               5                   10                  15      


Ala Gly Ile Leu Leu Thr Leu Gly Leu Leu Ile Gly Phe Ser Ser Pro 
            20                  25                  30          


Val Gly Ala Gly Arg Val Ser Ile Asp Leu Pro Val Tyr Ala Lys Gly 
        35                  40                  45              


Arg Asn Glu Asn Gln Ala Ala Ile Asp Lys Gly Asn Val Pro Lys Leu 
    50                  55                  60                  


Trp Gln Ser Gly Asn Arg Gly Gln Gly Met Val Val Ala Val Ile Asp 
65                  70                  75                  80  


Thr Gly Ile Gln Pro His Lys Asp Phe Arg Leu Thr Ser Pro Gly Thr 
                85                  90                  95      


Ala Lys Ile Ser Lys Ala Asp Ala Gln Arg Met Ile Ala Gln Lys Gly 
            100                 105                 110         


Tyr Gly Arg Tyr Val Asn Ser Lys Ile Pro Phe Ala Tyr Asn Tyr Ala 
        115                 120                 125             


Ser Asn Ser Asn Gln Ala Thr Glu Pro Asp Asp Val Ser Gly Phe His 
    130                 135                 140                 


Gly Gln His Val Ala Gly Ile Ile Ala Ala Asn Gly Arg Tyr Thr Lys 
145                 150                 155                 160 


Lys Gln His Glu Tyr Val Val Gly Val Ala Pro Glu Ala Gln Leu Leu 
                165                 170                 175     


Asp Leu Arg Val Ser Asp Met Ile Asp Asp Glu Asn Lys Asn Asp Val 
            180                 185                 190         


Ala Arg Ala Ile His Asp Ala Val Asp Leu Gly Ala Asn Val Ile Ser 
        195                 200                 205             


Ile Ser Leu Gly Ile Ser Leu Pro Asn Gln Ser Phe Thr Asp Glu Glu 
    210                 215                 220                 


Gln Ala Ala Val Gln Tyr Ala Ile Asn His Gly Val Phe Val Ser Leu 
225                 230                 235                 240 


Ala Gly Gly Asn Tyr Gly Asn Ser Ala Ser Ile Phe Thr Ser Asn Pro 
                245                 250                 255     


Leu Thr Asn Thr Asn Gly Ile Asn Thr Ala Tyr Gln Glu Ala Asn Ser 
            260                 265                 270         


Gly Thr Leu Ala Asp Pro Ala Val Ser Ala Asn Ser Met Thr Val Ala 
        275                 280                 285             


Ala Glu Asn Ser Leu Lys Gly Ser Gln Asn Glu Met Ala Ser Phe Ser 
    290                 295                 300                 


Ser Trp Gly Pro Thr Pro Asp Tyr Thr Leu Lys Pro Asp Ile Ser Val 
305                 310                 315                 320 


Pro Gly Met Gly Ile Thr Ser Thr Trp Gln Asn Asn Thr Tyr Ala Met 
                325                 330                 335     


Leu Glu Gly Thr Ser Met Ala Thr Pro Phe Val Ser Gly Ala Ala Ala 
            340                 345                 350         


Leu Val Ile Gln Lys Leu Lys Gln Ser Gln Pro Asp Leu Ser Gly Ser 
        355                 360                 365             


Gln Leu Val Ser Gln Thr Lys Asn Met Leu Met Asn Ser Ala Thr Pro 
    370                 375                 380                 


Met Lys Asp Val Asn Tyr Pro Gly Asn Ile Val Ser Pro Arg Arg Gln 
385                 390                 395                 400 


Gly Ala Gly Gln Ile Asn Val Thr Ala Ala Ala Asn Leu Lys Ala Thr 
                405                 410                 415     


Val Gln Asp Pro Ala Thr Gly Ile Gly Ser Val Ser Leu Gly Gln Ile 
            420                 425                 430         


Gly Gly Ser His Ser Phe Lys Val Glu Leu Ser Asn His Gly Ser Val 
        435                 440                 445             


Pro Ile Asn Tyr Ala Val Asp Asn Asp Gly Gly Pro Met Thr Gln Ile 
    450                 455                 460                 


Arg Asp Gln Lys Lys Asp Gly Gln Val His Asp Ile Ser Leu Thr Gly 
465                 470                 475                 480 


Ala Ser Leu Thr Ser Asp Gln Ser Asn Ile Val Ile Asp Pro Gly Gln 
                485                 490                 495     


Arg Lys Thr Leu Thr Leu Ser Leu Ser Ile Ser Pro Thr Val Lys Pro 
            500                 505                 510         


Asn Gln Val Val Glu Gly Tyr Leu His Phe Lys Ala Asp Gln Pro Gly 
        515                 520                 525             


Gln Ser Leu Ser Met Pro Tyr Leu Ala Tyr Tyr Gly Asp Thr Thr Lys 
    530                 535                 540                 


Glu Gln Val Ile Asp Ser Pro Ala Phe Met Pro Asn Ser Ala Phe His 
545                 550                 555                 560 


Gly Gly Tyr Leu Met Asp Glu Asn Asn Thr Pro Leu Gly Ile Ser Asp 
                565                 570                 575     


Arg Val Ser Leu Ser Ala Tyr Val Asn Asn His Asp Asn Lys Thr Asn 
            580                 585                 590         


Trp Arg Lys Val Ala Ser Tyr Ile His Pro Ala Arg Val Ala Phe Ser 
        595                 600                 605             


Pro Asn Gly Asp His His Gln Asp Ser Val Thr Pro Phe Val Phe Ala 
    610                 615                 620                 


Lys Gln Ser Leu Ala Asn Val Lys Ala Gln Ile Val Asn Asp Gln Gly 
625                 630                 635                 640 


Asn Val Ile Arg Val Ile Asp Gln Glu Thr Asp Thr Asp Lys Ser Ile 
                645                 650                 655     


Ala Asn Asp Ser Gly Asn Leu Asp Leu Ser Thr Ser Phe Ser Met Arg 
            660                 665                 670         


Gln Asn Pro Lys Ala Leu Gln Trp Asn Gly Arg Tyr Ile Asp Gln Ser 
        675                 680                 685             


Thr Gly Lys Ser Ile Val Val Pro Asn Gly Arg Tyr His Tyr Gln Leu 
    690                 695                 700                 


Val Thr Thr Asn Tyr Asn Asp Gly Ala Asp Gln Gln Gln Leu Ala Ser 
705                 710                 715                 720 


Tyr Pro Val Glu Val Asp Thr Arg Ala Pro Gln Ala Thr Ala Val Thr 
                725                 730                 735     


Tyr Asn Arg Lys Thr Gly Arg Leu Thr Gly Gln Phe Asn Asp His Gly 
            740                 745                 750         


Ala Gly Phe Thr Gly Ile Ser Arg Gly Ile Leu Ser Thr Asn Gly His 
        755                 760                 765             


Gln Phe Gly Ile Lys Leu Thr Lys Lys Ala Ala Leu Ala Gly Gln Phe 
    770                 775                 780                 


Ser Asp Arg Leu Thr Ser Ile Val Lys Gln Met Leu Met Lys His Gln 
785                 790                 795                 800 


Ala Asn Leu Thr Leu Thr Asp Ile Ala Gly Asn Ser Thr Lys Val Ala 
                805                 810                 815     


Val His Arg Lys Leu Ser Gly Leu Val Thr Lys Lys Ala Asn Val Ser 
            820                 825                 830         


Phe Asp Arg Ala Pro Gln Leu Lys Trp Phe Lys Tyr Gly Thr Gly Lys 
        835                 840                 845             


Asn Ala Ser Ser Ser Tyr Leu Glu Ile Ser Asn Lys Lys Val Phe Thr 
    850                 855                 860                 


Leu Tyr Ala Arg Val Pro Lys Gly Val Pro Ala Leu Asn Ala Tyr Ala 
865                 870                 875                 880 


Lys Asp Thr Gly Thr Asn Lys Val Val Lys Gly Arg Leu Asn Pro Lys 
                885                 890                 895     


Thr Gly Val Val Ala Phe Thr Cys His Phe Ser Gln Thr Gly Tyr Glu 
            900                 905                 910         


Thr Ile Gln Gly Trp Ser Gln Val Pro Gln Lys Lys Phe Gly Ala Tyr 
        915                 920                 925             


Leu Lys Ser Pro Ser Thr Leu Ile Val Val Ser Gln Leu Pro Lys Ala 
    930                 935                 940                 


Pro Leu Ile Ala Lys Leu Lys Lys Thr Thr Pro Lys Leu Ile Ser Asn 
945                 950                 955                 960 


Ala Gln Ala Gln Lys Lys Thr Lys Ser Ile Phe Gly Ser Pro Ile Pro 
                965                 970                 975     


Asn Gly His Lys Thr Ser Gln Leu Thr Tyr Arg Arg Ala Pro Ser Lys 
            980                 985                 990         


Gly Ile Lys Phe Phe Gln Leu His  Asp Asn Ala Ser Thr  Phe Leu Asn 
        995                 1000                 1005             


Ala Ala  Asn Ser Ala Thr Ile  Tyr Asp Leu Gln Thr  His Gln Leu 
    1010                 1015                 1020             


Thr Ile  Asn Gly Gln Ile Ser  Ser Pro Asn Lys Gln  Arg Leu Val 
    1025                 1030                 1035             


Ile Leu  Ala Thr Pro Asp Glu  Thr Asp Pro Ala Asn  Arg Val Arg 
    1040                 1045                 1050             


Ile Ser  Lys Asn Gly Thr Phe  Lys Phe Lys Val Pro  Phe Asn Pro 
    1055                 1060                 1065             


Thr Glu  Gln Arg Gly Val Gly  Tyr Asn Leu Tyr Thr  Lys Thr Ile 
    1070                 1075                 1080             


Leu Arg  Asn Gly Gln Ser Lys  Val Gln Lys Gln Arg  Gly Ile Leu 
    1085                 1090                 1095             


Glu Ile  Tyr Leu Asp Val Val  Lys Pro Ser Leu Ala  Val Ser Glu 
    1100                 1105                 1110             


Asn Val  Glu Asn Asn Arg Ile  Arg Leu Thr Gly Thr  Val Asn Asp 
    1115                 1120                 1125             


Asn Val  Ser Gly Val Lys Leu  Asp Val Asn Gly Asn  Asn Leu Phe 
    1130                 1135                 1140             


Ser Gln  Gln Lys Asp Ala Gly  Phe Asn Arg His Asp  Gln Asn Gln 
    1145                 1150                 1155             


Pro Leu  Asn Pro Tyr Pro Asp  Tyr Gln Ile Asn Gln  Ser Tyr Asp 
    1160                 1165                 1170             


Leu Thr  Pro Gly Arg Asn Thr  Phe Thr Val Lys Ala  Ile Asp Gln 
    1175                 1180                 1185             


Val Gly  Asn Val Thr Thr Lys  Arg Phe Val Ala Asn  Gly His Gly 
    1190                 1195                 1200             


<210>  40
<211>  1178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Lactobacillus brevis subsp. gravesensis ATCC 27305 
       protease

<400>  40

Leu Ile Gly Phe Ser Ser Pro Val Gly Ala Gly Arg Val Ser Ile Asp 
1               5                   10                  15      


Leu Pro Val Tyr Ala Lys Gly Arg Asn Glu Asn Gln Ala Ala Ile Asp 
            20                  25                  30          


Lys Gly Asn Val Pro Lys Leu Trp Gln Ser Gly Asn Arg Gly Gln Gly 
        35                  40                  45              


Met Val Val Ala Val Ile Asp Thr Gly Ile Gln Pro His Lys Asp Phe 
    50                  55                  60                  


Arg Leu Thr Ser Pro Gly Thr Ala Lys Ile Ser Lys Ala Asp Ala Gln 
65                  70                  75                  80  


Arg Met Ile Ala Gln Lys Gly Tyr Gly Arg Tyr Val Asn Ser Lys Ile 
                85                  90                  95      


Pro Phe Ala Tyr Asn Tyr Ala Ser Asn Ser Asn Gln Ala Thr Glu Pro 
            100                 105                 110         


Asp Asp Val Ser Gly Phe His Gly Gln His Val Ala Gly Ile Ile Ala 
        115                 120                 125             


Ala Asn Gly Arg Tyr Thr Lys Lys Gln His Glu Tyr Val Val Gly Val 
    130                 135                 140                 


Ala Pro Glu Ala Gln Leu Leu Asp Leu Arg Val Ser Asp Met Ile Asp 
145                 150                 155                 160 


Asp Glu Asn Lys Asn Asp Val Ala Arg Ala Ile His Asp Ala Val Asp 
                165                 170                 175     


Leu Gly Ala Asn Val Ile Ser Ile Ser Leu Gly Ile Ser Leu Pro Asn 
            180                 185                 190         


Gln Ser Phe Thr Asp Glu Glu Gln Ala Ala Val Gln Tyr Ala Ile Asn 
        195                 200                 205             


His Gly Val Phe Val Ser Leu Ala Gly Gly Asn Tyr Gly Asn Ser Ala 
    210                 215                 220                 


Ser Ile Phe Thr Ser Asn Pro Leu Thr Asn Thr Asn Gly Ile Asn Thr 
225                 230                 235                 240 


Ala Tyr Gln Glu Ala Asn Ser Gly Thr Leu Ala Asp Pro Ala Val Ser 
                245                 250                 255     


Ala Asn Ser Met Thr Val Ala Ala Glu Asn Ser Leu Lys Gly Ser Gln 
            260                 265                 270         


Asn Glu Met Ala Ser Phe Ser Ser Trp Gly Pro Thr Pro Asp Tyr Thr 
        275                 280                 285             


Leu Lys Pro Asp Ile Ser Val Pro Gly Met Gly Ile Thr Ser Thr Trp 
    290                 295                 300                 


Gln Asn Asn Thr Tyr Ala Met Leu Glu Gly Thr Ser Met Ala Thr Pro 
305                 310                 315                 320 


Phe Val Ser Gly Ala Ala Ala Leu Val Ile Gln Lys Leu Lys Gln Ser 
                325                 330                 335     


Gln Pro Asp Leu Ser Gly Ser Gln Leu Val Ser Gln Thr Lys Asn Met 
            340                 345                 350         


Leu Met Asn Ser Ala Thr Pro Met Lys Asp Val Asn Tyr Pro Gly Asn 
        355                 360                 365             


Ile Val Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asn Val Thr Ala 
    370                 375                 380                 


Ala Ala Asn Leu Lys Ala Thr Val Gln Asp Pro Ala Thr Gly Ile Gly 
385                 390                 395                 400 


Ser Val Ser Leu Gly Gln Ile Gly Gly Ser His Ser Phe Lys Val Glu 
                405                 410                 415     


Leu Ser Asn His Gly Ser Val Pro Ile Asn Tyr Ala Val Asp Asn Asp 
            420                 425                 430         


Gly Gly Pro Met Thr Gln Ile Arg Asp Gln Lys Lys Asp Gly Gln Val 
        435                 440                 445             


His Asp Ile Ser Leu Thr Gly Ala Ser Leu Thr Ser Asp Gln Ser Asn 
    450                 455                 460                 


Ile Val Ile Asp Pro Gly Gln Arg Lys Thr Leu Thr Leu Ser Leu Ser 
465                 470                 475                 480 


Ile Ser Pro Thr Val Lys Pro Asn Gln Val Val Glu Gly Tyr Leu His 
                485                 490                 495     


Phe Lys Ala Asp Gln Pro Gly Gln Ser Leu Ser Met Pro Tyr Leu Ala 
            500                 505                 510         


Tyr Tyr Gly Asp Thr Thr Lys Glu Gln Val Ile Asp Ser Pro Ala Phe 
        515                 520                 525             


Met Pro Asn Ser Ala Phe His Gly Gly Tyr Leu Met Asp Glu Asn Asn 
    530                 535                 540                 


Thr Pro Leu Gly Ile Ser Asp Arg Val Ser Leu Ser Ala Tyr Val Asn 
545                 550                 555                 560 


Asn His Asp Asn Lys Thr Asn Trp Arg Lys Val Ala Ser Tyr Ile His 
                565                 570                 575     


Pro Ala Arg Val Ala Phe Ser Pro Asn Gly Asp His His Gln Asp Ser 
            580                 585                 590         


Val Thr Pro Phe Val Phe Ala Lys Gln Ser Leu Ala Asn Val Lys Ala 
        595                 600                 605             


Gln Ile Val Asn Asp Gln Gly Asn Val Ile Arg Val Ile Asp Gln Glu 
    610                 615                 620                 


Thr Asp Thr Asp Lys Ser Ile Ala Asn Asp Ser Gly Asn Leu Asp Leu 
625                 630                 635                 640 


Ser Thr Ser Phe Ser Met Arg Gln Asn Pro Lys Ala Leu Gln Trp Asn 
                645                 650                 655     


Gly Arg Tyr Ile Asp Gln Ser Thr Gly Lys Ser Ile Val Val Pro Asn 
            660                 665                 670         


Gly Arg Tyr His Tyr Gln Leu Val Thr Thr Asn Tyr Asn Asp Gly Ala 
        675                 680                 685             


Asp Gln Gln Gln Leu Ala Ser Tyr Pro Val Glu Val Asp Thr Arg Ala 
    690                 695                 700                 


Pro Gln Ala Thr Ala Val Thr Tyr Asn Arg Lys Thr Gly Arg Leu Thr 
705                 710                 715                 720 


Gly Gln Phe Asn Asp His Gly Ala Gly Phe Thr Gly Ile Ser Arg Gly 
                725                 730                 735     


Ile Leu Ser Thr Asn Gly His Gln Phe Gly Ile Lys Leu Thr Lys Lys 
            740                 745                 750         


Ala Ala Leu Ala Gly Gln Phe Ser Asp Arg Leu Thr Ser Ile Val Lys 
        755                 760                 765             


Gln Met Leu Met Lys His Gln Ala Asn Leu Thr Leu Thr Asp Ile Ala 
    770                 775                 780                 


Gly Asn Ser Thr Lys Val Ala Val His Arg Lys Leu Ser Gly Leu Val 
785                 790                 795                 800 


Thr Lys Lys Ala Asn Val Ser Phe Asp Arg Ala Pro Gln Leu Lys Trp 
                805                 810                 815     


Phe Lys Tyr Gly Thr Gly Lys Asn Ala Ser Ser Ser Tyr Leu Glu Ile 
            820                 825                 830         


Ser Asn Lys Lys Val Phe Thr Leu Tyr Ala Arg Val Pro Lys Gly Val 
        835                 840                 845             


Pro Ala Leu Asn Ala Tyr Ala Lys Asp Thr Gly Thr Asn Lys Val Val 
    850                 855                 860                 


Lys Gly Arg Leu Asn Pro Lys Thr Gly Val Val Ala Phe Thr Cys His 
865                 870                 875                 880 


Phe Ser Gln Thr Gly Tyr Glu Thr Ile Gln Gly Trp Ser Gln Val Pro 
                885                 890                 895     


Gln Lys Lys Phe Gly Ala Tyr Leu Lys Ser Pro Ser Thr Leu Ile Val 
            900                 905                 910         


Val Ser Gln Leu Pro Lys Ala Pro Leu Ile Ala Lys Leu Lys Lys Thr 
        915                 920                 925             


Thr Pro Lys Leu Ile Ser Asn Ala Gln Ala Gln Lys Lys Thr Lys Ser 
    930                 935                 940                 


Ile Phe Gly Ser Pro Ile Pro Asn Gly His Lys Thr Ser Gln Leu Thr 
945                 950                 955                 960 


Tyr Arg Arg Ala Pro Ser Lys Gly Ile Lys Phe Phe Gln Leu His Asp 
                965                 970                 975     


Asn Ala Ser Thr Phe Leu Asn Ala Ala Asn Ser Ala Thr Ile Tyr Asp 
            980                 985                 990         


Leu Gln Thr His Gln Leu Thr Ile  Asn Gly Gln Ile Ser  Ser Pro Asn 
        995                 1000                 1005             


Lys Gln  Arg Leu Val Ile Leu  Ala Thr Pro Asp Glu  Thr Asp Pro 
    1010                 1015                 1020             


Ala Asn  Arg Val Arg Ile Ser  Lys Asn Gly Thr Phe  Lys Phe Lys 
    1025                 1030                 1035             


Val Pro  Phe Asn Pro Thr Glu  Gln Arg Gly Val Gly  Tyr Asn Leu 
    1040                 1045                 1050             


Tyr Thr  Lys Thr Ile Leu Arg  Asn Gly Gln Ser Lys  Val Gln Lys 
    1055                 1060                 1065             


Gln Arg  Gly Ile Leu Glu Ile  Tyr Leu Asp Val Val  Lys Pro Ser 
    1070                 1075                 1080             


Leu Ala  Val Ser Glu Asn Val  Glu Asn Asn Arg Ile  Arg Leu Thr 
    1085                 1090                 1095             


Gly Thr  Val Asn Asp Asn Val  Ser Gly Val Lys Leu  Asp Val Asn 
    1100                 1105                 1110             


Gly Asn  Asn Leu Phe Ser Gln  Gln Lys Asp Ala Gly  Phe Asn Arg 
    1115                 1120                 1125             


His Asp  Gln Asn Gln Pro Leu  Asn Pro Tyr Pro Asp  Tyr Gln Ile 
    1130                 1135                 1140             


Asn Gln  Ser Tyr Asp Leu Thr  Pro Gly Arg Asn Thr  Phe Thr Val 
    1145                 1150                 1155             


Lys Ala  Ile Asp Gln Val Gly  Asn Val Thr Thr Lys  Arg Phe Val 
    1160                 1165                 1170             


Ala Asn  Gly His Gly 
    1175             


<210>  41
<211>  1625
<212>  PRT
<213>  Lactobacillus helveticus

<400>  41

Met Lys Glu Leu Ser Glu His Ser Ser Glu Lys Phe Val Tyr Leu Asn 
1               5                   10                  15      


Arg Ser Lys Lys Arg Leu Asp Asn Leu Glu Ser Tyr Thr His Ser Lys 
            20                  25                  30          


Phe Leu Lys Thr Leu Arg Lys Lys Trp Ala Lys Ala Ala Ile Val Thr 
        35                  40                  45              


Leu Ala Ser Gly Ser Ala Ile Leu Phe Ser Ala Asn Lys Val Lys Ala 
    50                  55                  60                  


Asp Glu Val Glu Gln Asn Gln Ala Thr Glu Val Gln Gln Gly Ser Gln 
65                  70                  75                  80  


Ala Thr Asp Gln Thr Gln Asn Gln Ser Asp Asn Ser Glu Asn Thr Gly 
                85                  90                  95      


Gln Gln Asn Ser Asp Asn Gly Gln Ala Asp Thr Gln Val Asp Glu Val 
            100                 105                 110         


Gln Thr Ala Asp Lys Ala Gly Gln Lys Asp Ala Asn Gly Val Glu Leu 
        115                 120                 125             


Pro Ala Asn Asn Gln Asp His Val Lys Gly Asn Val Gln Asp Ala Trp 
    130                 135                 140                 


Asn Gln Gly Tyr Ser Gly Glu His Met Ala Val Ala Val Ile Asp Ser 
145                 150                 155                 160 


Gly Ile Asp Val Asp His Lys Asp Phe Gln Thr Met Pro Lys Asp Pro 
                165                 170                 175     


Lys Leu Thr Ala Asp Glu Met Lys Lys Lys Leu Lys Glu Leu Gly Tyr 
            180                 185                 190         


Gly Arg Tyr Val Asn Glu Lys Ile Pro Tyr Ala Tyr Asn Tyr Val Asp 
        195                 200                 205             


Asn Glu Asn Glu His Leu Lys Gly Pro Asp Asp Glu Pro His Gly Gln 
    210                 215                 220                 


His Val Ser Gly Thr Ile Ala Ala Asp Gly His Pro Asp Gly Asp Lys 
225                 230                 235                 240 


Glu Tyr Val Val Gly Val Ala Pro Gln Ala Gln Leu Leu His Leu Lys 
                245                 250                 255     


Val Phe Gly Asp Thr Thr Thr Ser Leu Asp Leu Ala Lys Glu Ile Tyr 
            260                 265                 270         


Asp Ala Val Asn Leu Gly Ala Asp Val Ile Gln Met Ser Leu Gly Gly 
        275                 280                 285             


Gly Val Ser Ala Ala Asp Leu Asn Asn Ala Asp Gln Arg Ala Val Gln 
    290                 295                 300                 


Tyr Ala Ile Asp His Gly Val Ile Val Ser Ile Ser Ala Ser Asn Asn 
305                 310                 315                 320 


Gly Asn Ser Ala Ser Val Asp Asn Pro Ser Lys Ile Thr Asp Leu Asp 
                325                 330                 335     


Asp Tyr Glu Pro Gly Gly Glu Arg Gly Asn Tyr Leu Pro Phe Ser Ser 
            340                 345                 350         


Ser Thr Val Ala Asn Pro Gly Ala Ala Lys Gly Ala Ile Thr Val Ala 
        355                 360                 365             


Ala Glu Asn Ser Gly Leu Gly Lys Asp Ser Asp Met Ala Ser Phe Ser 
    370                 375                 380                 


Ser Trp Gly Pro Leu Pro Asp Tyr Thr Leu Lys Pro Asp Ile Ser Ala 
385                 390                 395                 400 


Pro Gly Val Asp Val Ile Ser Thr Ala Asn Asp Asn Gly Tyr Thr Thr 
                405                 410                 415     


Met Ser Gly Thr Ser Met Ala Gly Pro Phe Val Ala Gly Ala Ala Thr 
            420                 425                 430         


Leu Val Lys Gln Arg Leu Leu Lys Thr Asn Pro Glu Leu Lys Gly Ala 
        435                 440                 445             


Ala Leu Val Glu Ala Val Lys Ala Leu Leu Met Asn Thr Ala Val Pro 
    450                 455                 460                 


Gln Thr Gln Lys Gly Phe Asp Thr Pro Val Ser Pro Arg Arg Gln Gly 
465                 470                 475                 480 


Ser Gly Gln Ile Asp Val Gly Ala Ala Thr Lys Ser Pro Val Tyr Ile 
                485                 490                 495     


Thr Ala Asp Asp Gly Thr Gly Ser Leu Ser Leu Arg Gln Ile Lys Asp 
            500                 505                 510         


Gly Ser Glu Phe Ala Leu Thr Phe His Asn Leu Ser Asn Gln Val Gln 
        515                 520                 525             


Ala Tyr Asp Phe Asp Asp Met Gly Gly Gly Phe Thr Glu Val Arg Asp 
    530                 535                 540                 


Glu Glu Thr Gly Leu Phe His Asp Val Gln Leu Ala Gly Ala Asn Ile 
545                 550                 555                 560 


Ser Gly Pro Asn Ser Val Glu Leu Ala Pro Asn Glu Thr Lys Thr Val 
                565                 570                 575     


Asn Phe Val Leu Asn Leu Ala Gly Leu Lys Asn Asn Gln Leu Val Glu 
            580                 585                 590         


Gly Phe Leu Asn Phe Lys Ser Ser Lys Gly Ala Asn Asp Leu Ser Val 
        595                 600                 605             


Pro Tyr Leu Gly Tyr Phe Gly Asp Met Thr Ser Glu Asn Val Phe Asp 
    610                 615                 620                 


Gln Asn Ala Asn Asp Ala Ala Pro Asp Ile Gln Gly Asn His Leu Ile 
625                 630                 635                 640 


Asn Glu Asp Asn Tyr Pro Arg Gly Ile Ala Asp Glu Glu Ser Leu Lys 
                645                 650                 655     


Ala Leu Val Asn Val Asp Gly Thr Tyr Asn Trp Gln Glu Val Ala Lys 
            660                 665                 670         


Leu Tyr Glu Ser Gly Lys Val Ala Phe Ser Pro Asn Asn Asn Gln Lys 
        675                 680                 685             


Ser Asp Leu Leu Lys Pro Val Ala Phe Leu Lys Gln Asn Leu Glu Asp 
    690                 695                 700                 


Leu Lys Val Glu Ile Leu Asp Ala Asn Gly Asn Val Val Arg Val Leu 
705                 710                 715                 720 


Ser Asp Asn His Gly Pro Glu Lys Ser Tyr His Asp Asp His Asn Gly 
                725                 730                 735     


Met Met Asp Leu Ser Ser Thr Val Asn Asn Ser Asp Thr Leu Glu Trp 
            740                 745                 750         


Asp Gly Lys Leu Tyr Asp Lys Thr Thr Gly Lys Met Val Val Ala Pro 
        755                 760                 765             


Asp Gly Gln Tyr Thr Tyr Arg Phe Val Ala Thr Leu Tyr Asn Asn Gly 
    770                 775                 780                 


Glu Asn Lys Val Gln Thr Asn Asp Thr Pro Val Ile Ile Asp Thr Thr 
785                 790                 795                 800 


Ala Pro Val Leu Asn Asn Val Lys Tyr Asp Thr Ser Ser Phe Thr Leu 
                805                 810                 815     


Ser Gly Asp Tyr Ala Asp Ala Gly Ala Gly Phe Thr Asp Tyr Ser Tyr 
            820                 825                 830         


Ala Thr Val Thr Val Asn Asp His Val Phe Gly Phe Lys Leu Asn Glu 
        835                 840                 845             


Gly Asp Lys Ser Asn Phe Asp Asn Ala Asn Lys Thr Lys Gly His Phe 
    850                 855                 860                 


Val Phe Val Leu Thr Pro Glu Glu Gln Ala Ala Leu Thr Ser Ala Ala 
865                 870                 875                 880 


Asn Lys Val Thr Val Ala Phe Ser Asp Val Ala Asp Asn Thr Ala Thr 
                885                 890                 895     


Gln Thr Phe Asn Val Ala Pro Val Ala Gly His Lys Lys Ile Ala Val 
            900                 905                 910         


Trp Asn Ala Ile Asn Gly Leu Pro Phe Asn Glu Asn Ser Asp Asp Tyr 
        915                 920                 925             


Asn Val Gly Arg Lys Val Phe Met Leu Arg Gly Gly Ala Glu His Asp 
    930                 935                 940                 


Phe Tyr Val Asn Gly Lys Trp Val Gln Val Asp Gln Gly Gln Phe Val 
945                 950                 955                 960 


Leu Pro Val Ser Val Asp Glu Gln Asn Phe Val Phe Ser Ser Asp Gln 
                965                 970                 975     


Ala Gly Lys Asn Ile Leu Gly Lys Phe Thr Thr Phe Thr Pro Lys Ala 
            980                 985                 990         


Gln Phe Ala Trp Gln His Val Asp  Gly Glu Glu Arg Ser  Phe Gly Val 
        995                 1000                 1005             


Ser Val  Tyr Ser Val Glu Gly  Lys Asp Pro Gln Asp  Ile Val Val 
    1010                 1015                 1020             


Gln Ala  Ala Val Pro Lys Gly  Asp Asn Val Lys Ala  Phe Ala Lys 
    1025                 1030                 1035             


Asp Tyr  Phe Thr His Glu Val  Tyr Thr Gly Glu Val  His Asp Gly 
    1040                 1045                 1050             


Val Ala  Thr Phe His Ile His  Thr Ser Val Asn Lys  Asp Ala Ala 
    1055                 1060                 1065             


Thr Gly  Ile Asn Leu Arg Ala  Leu Leu Gln Gly Trp  Val Glu Ile 
    1070                 1075                 1080             


Asp Gly  Pro Thr Phe Asn Ala  Lys Gln Val Thr Asp  Pro Ser Pro 
    1085                 1090                 1095             


Ile Asn  Asp Ala Asn Tyr Leu  Gly Val Tyr Tyr Asn  Pro Asn Ala 
    1100                 1105                 1110             


Glu Glu  Arg Lys Asn Tyr Asp  Asn Arg Asp Asp Leu  Gly Val Asp 
    1115                 1120                 1125             


Phe Glu  Asp Glu Ala Ala Asp  Thr Asn Thr Phe Gly  Pro Gly Asn 
    1130                 1135                 1140             


His Ser  Ser Ala Lys Asp Asp  Ala Lys Ile His Phe  Asp Tyr Leu 
    1145                 1150                 1155             


Asn Asn  Asn Asp Ile Ser Thr  Leu Gly Asn Lys Ala  Val Glu Lys 
    1160                 1165                 1170             


Gly Tyr  Tyr Asn Pro Ala Thr  His Lys Phe Thr Leu  Thr Gly Arg 
    1175                 1180                 1185             


Val Asn  Pro Glu Val Ile Ser  Leu Thr Phe Leu Ala  Asp Ser Pro 
    1190                 1195                 1200             


Tyr Glu  Val Asp Pro Glu Asn  Gln Ala Asp Ile His  Asp Asn Gly 
    1205                 1210                 1215             


Lys Phe  Ser Val Thr Phe Thr  Ile Asp Asn Pro Ala  Thr Arg Gln 
    1220                 1225                 1230             


Leu Ser  Tyr Phe Phe Lys Thr  Asn Asp Gly Lys Thr  Thr Arg Gly 
    1235                 1240                 1245             


Ser Leu  Thr Leu Ile Leu Asp  Thr Val Asp Pro Thr  Leu Thr Val 
    1250                 1255                 1260             


Asp Gln  Leu Gly Asp Lys Asp  Glu Ala Glu Ile Thr  Thr Asn Lys 
    1265                 1270                 1275             


Pro Thr  Phe Lys Leu Ser Gly  Glu Ala Asn Asp Asn  Ile Asp Gly 
    1280                 1285                 1290             


Tyr Asn  Val Phe Ile Asn Gly  Asp Asn Val Phe Gly  Gln Phe Gly 
    1295                 1300                 1305             


Asn Ser  Gly Tyr Asp Phe Leu  Pro Gly Ile Tyr Asn  Asp Leu Asn 
    1310                 1315                 1320             


Gln Asn  Thr Pro Asn Leu Tyr  Gly Ser Tyr Lys Phe  Asp Gln Glu 
    1325                 1330                 1335             


Glu Gln  Leu Asp Asp Gln Asn  Gly Gln Pro Thr Thr  His Val Phe 
    1340                 1345                 1350             


Thr Ile  Ala Val Glu Asp Gln  Ala Gly Asn Arg Val  Glu Lys Lys 
    1355                 1360                 1365             


Val Thr  Val His Tyr Asp Pro  Asn Tyr Leu Thr Glu  Pro Val Asn 
    1370                 1375                 1380             


Thr Gly  Lys Lys Asp Asp Gln  Ala Asp Val Lys Pro  Ala Glu Gly 
    1385                 1390                 1395             


Gln Lys  Gln Asp Lys Asn Asp  Asn Gln Thr Val Asn  Asn Ser Lys 
    1400                 1405                 1410             


Glu Asp  Pro Glu Ser Gly Gln  Thr Thr Glu Asn Ala  Gln Ser Thr 
    1415                 1420                 1425             


Glu Ser  Gln Glu Gln Asn Lys  Thr Asp Val Thr Lys  Pro Ala Ala 
    1430                 1435                 1440             


Lys Pro  Ser Asn Asp Asp Gln  Lys Glu Asn His Gly  Ala Gly Glu 
    1445                 1450                 1455             


Ser Thr  Ile Glu Ser Asn Gln  Glu Lys Gln Leu Gly  Gln Ser Asn 
    1460                 1465                 1470             


Val Gln  Ala Gln Asp Thr Lys  Pro Asp Lys Thr Val  Val Gln Gly 
    1475                 1480                 1485             


Asn Val  Gln Asn Thr Ala Pro  Thr Thr Gly His Leu  Thr Asn Ser 
    1490                 1495                 1500             


Ser Val  Asn Val Gln Gln Phe  Lys Thr Lys Lys Glu  Thr Leu Gln 
    1505                 1510                 1515             


Leu Lys  Lys Phe Lys Leu Leu  Lys Asn Thr Tyr Gly  Tyr Thr Leu 
    1520                 1525                 1530             


Asn Gly  Lys Ile Ala Lys Lys  His Gly Lys Lys Leu  Leu Phe Asn 
    1535                 1540                 1545             


Lys Gly  Lys Thr Val Leu Val  Trp Asn Asn Arg Lys  Val Val Thr 
    1550                 1555                 1560             


Ile Lys  Gly Gln Lys Tyr Tyr  Arg Val Ala Lys Asn  Val Phe Val 
    1565                 1570                 1575             


Lys Val  Ser Thr Ile Lys Gln  Val Lys Asp Leu Lys  Leu Val Leu 
    1580                 1585                 1590             


Thr Lys  Asn Ser Tyr Val Tyr  Asn Lys Leu Gly Lys  Arg Val Lys 
    1595                 1600                 1605             


Tyr Lys  Ser Gln Ser Leu Ile  Lys Glu Gly Lys His  Leu Ser Thr 
    1610                 1615                 1620             


His Gln  
    1625 


<210>  42
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Lactobacillus helveticus DSM 20075 = CGMCC 1.1877 
       protease

<400>  42

Glu Gln Asn Gln Ala Thr Glu Val Gln Gln Gly Ser Gln Ala Thr Asp 
1               5                   10                  15      


Gln Thr Gln Asn Gln Ser Asp Asn Ser Glu Asn Thr Gly Gln Gln Asn 
            20                  25                  30          


Ser Asp Asn Gly Gln Ala Asp Thr Gln Val Asp Glu Val Gln Thr Ala 
        35                  40                  45              


Asp Lys Ala Gly Gln Lys Asp Ala Asn Gly Val Glu Leu Pro Ala Asn 
    50                  55                  60                  


Asn Gln Asp His Val Lys Gly Asn Val Gln Asp Ala Trp Asn Gln Gly 
65                  70                  75                  80  


Tyr Ser Gly Glu His Met Ala Val Ala Val Ile Asp Ser Gly Ile Asp 
                85                  90                  95      


Val Asp His Lys Asp Phe Gln Thr Met Pro Lys Asp Pro Lys Leu Thr 
            100                 105                 110         


Ala Asp Glu Met Lys Lys Lys Leu Lys Glu Leu Gly Tyr Gly Arg Tyr 
        115                 120                 125             


Val Asn Glu Lys Ile Pro Tyr Ala Tyr Asn Tyr Val Asp Asn Glu Asn 
    130                 135                 140                 


Glu His Leu Lys Gly Pro Asp Asp Glu Pro His Gly Gln His Val Ser 
145                 150                 155                 160 


Gly Thr Ile Ala Ala Asp Gly His Pro Asp Gly Asp Lys Glu Tyr Val 
                165                 170                 175     


Val Gly Val Ala Pro Gln Ala Gln Leu Leu His Leu Lys Val Phe Gly 
            180                 185                 190         


Asp Thr Thr Thr Ser Leu Asp Leu Ala Lys Glu Ile Tyr Asp Ala Val 
        195                 200                 205             


Asn Leu Gly Ala Asp Val Ile Gln Met Ser Leu Gly Gly Gly Val Ser 
    210                 215                 220                 


Ala Ala Asp Leu Asn Asn Ala Asp Gln Arg Ala Val Gln Tyr Ala Ile 
225                 230                 235                 240 


Asp His Gly Val Ile Val Ser Ile Ser Ala Ser Asn Asn Gly Asn Ser 
                245                 250                 255     


Ala Ser Val Asp Asn Pro Ser Lys Ile Thr Asp Leu Asp Asp Tyr Glu 
            260                 265                 270         


Pro Gly Gly Glu Arg Gly Asn Tyr Leu Pro Phe Ser Ser Ser Thr Val 
        275                 280                 285             


Ala Asn Pro Gly Ala Ala Lys Gly Ala Ile Thr Val Ala Ala Glu Asn 
    290                 295                 300                 


Ser Gly Leu Gly Lys Asp Ser Asp Met Ala Ser Phe Ser Ser Trp Gly 
305                 310                 315                 320 


Pro Leu Pro Asp Tyr Thr Leu Lys Pro Asp Ile Ser Ala Pro Gly Val 
                325                 330                 335     


Asp Val Ile Ser Thr Ala Asn Asp Asn Gly Tyr Thr Thr Met Ser Gly 
            340                 345                 350         


Thr Ser Met Ala Gly Pro Phe Val Ala Gly Ala Ala Thr Leu Val Lys 
        355                 360                 365             


Gln Arg Leu Leu Lys Thr Asn Pro Glu Leu Lys Gly Ala Ala Leu Val 
    370                 375                 380                 


Glu Ala Val Lys Ala Leu Leu Met Asn Thr Ala Val Pro Gln Thr Gln 
385                 390                 395                 400 


Lys Gly Phe Asp Thr Pro Val Ser Pro Arg Arg Gln Gly Ser Gly Gln 
                405                 410                 415     


Ile Asp Val Gly Ala Ala Thr Lys Ser Pro Val Tyr Ile Thr Ala Asp 
            420                 425                 430         


Asp Gly Thr Gly Ser Leu Ser Leu Arg Gln Ile Lys Asp Gly Ser Glu 
        435                 440                 445             


Phe Ala Leu Thr Phe His Asn Leu Ser Asn Gln Val Gln Ala Tyr Asp 
    450                 455                 460                 


Phe Asp Asp Met Gly Gly Gly Phe Thr Glu Val Arg Asp Glu Glu Thr 
465                 470                 475                 480 


Gly Leu Phe His Asp Val Gln Leu Ala Gly Ala Asn Ile Ser Gly Pro 
                485                 490                 495     


Asn Ser Val Glu Leu Ala Pro Asn Glu Thr Lys Thr Val Asn Phe Val 
            500                 505                 510         


Leu Asn Leu Ala Gly Leu Lys Asn Asn Gln Leu Val Glu Gly Phe Leu 
        515                 520                 525             


Asn Phe Lys Ser Ser Lys Gly Ala Asn Asp Leu Ser Val Pro Tyr Leu 
    530                 535                 540                 


Gly Tyr Phe Gly Asp Met Thr Ser Glu Asn Val Phe Asp Gln Asn Ala 
545                 550                 555                 560 


Asn Asp Ala Ala Pro Asp Ile Gln Gly Asn His Leu Ile Asn Glu Asp 
                565                 570                 575     


Asn Tyr Pro Arg Gly Ile Ala Asp Glu Glu Ser Leu Lys Ala Leu Val 
            580                 585                 590         


Asn Val Asp Gly Thr Tyr Asn Trp Gln Glu Val Ala Lys Leu Tyr Glu 
        595                 600                 605             


Ser Gly Lys Val Ala Phe Ser Pro Asn Asn Asn Gln Lys Ser Asp Leu 
    610                 615                 620                 


Leu Lys Pro Val Ala Phe Leu Lys Gln Asn Leu Glu Asp Leu Lys Val 
625                 630                 635                 640 


Glu Ile Leu Asp Ala Asn Gly Asn Val Val Arg Val Leu Ser Asp Asn 
                645                 650                 655     


His Gly Pro Glu Lys Ser Tyr His Asp Asp His Asn Gly Met Met Asp 
            660                 665                 670         


Leu Ser Ser Thr Val Asn Asn Ser Asp Thr Leu Glu Trp Asp Gly Lys 
        675                 680                 685             


Leu Tyr Asp Lys Thr Thr Gly Lys Met Val Val Ala Pro Asp Gly Gln 
    690                 695                 700                 


Tyr Thr Tyr Arg Phe Val Ala Thr Leu Tyr Asn Asn Gly Glu Asn Lys 
705                 710                 715                 720 


Val Gln Thr Asn Asp Thr Pro Val Ile Ile Asp Thr Thr Ala Pro Val 
                725                 730                 735     


Leu Asn Asn Val Lys Tyr Asp Thr Ser Ser Phe Thr Leu Ser Gly Asp 
            740                 745                 750         


Tyr Ala Asp Ala Gly Ala Gly Phe Thr Asp Tyr Ser Tyr Ala Thr Val 
        755                 760                 765             


Thr Val Asn Asp His Val Phe Gly Phe Lys Leu Asn Glu Gly Asp Lys 
    770                 775                 780                 


Ser Asn Phe Asp Asn Ala Asn Lys Thr Lys Gly His Phe Val Phe Val 
785                 790                 795                 800 


Leu Thr Pro Glu Glu Gln Ala Ala Leu Thr Ser Ala Ala Asn Lys Val 
                805                 810                 815     


Thr Val Ala Phe Ser Asp Val Ala Asp Asn Thr Ala Thr Gln Thr Phe 
            820                 825                 830         


Asn Val Ala Pro Val Ala Gly His Lys Lys Ile Ala Val Trp Asn Ala 
        835                 840                 845             


Ile Asn Gly Leu Pro Phe Asn Glu Asn Ser Asp Asp Tyr Asn Val Gly 
    850                 855                 860                 


Arg Lys Val Phe Met Leu Arg Gly Gly Ala Glu His Asp Phe Tyr Val 
865                 870                 875                 880 


Asn Gly Lys Trp Val Gln Val Asp Gln Gly Gln Phe Val Leu Pro Val 
                885                 890                 895     


Ser Val Asp Glu Gln Asn Phe Val Phe Ser Ser Asp Gln Ala Gly Lys 
            900                 905                 910         


Asn Ile Leu Gly Lys Phe Thr Thr Phe Thr Pro Lys Ala Gln Phe Ala 
        915                 920                 925             


Trp Gln His Val Asp Gly Glu Glu Arg Ser Phe Gly Val Ser Val Tyr 
    930                 935                 940                 


Ser Val Glu Gly Lys Asp Pro Gln Asp Ile Val Val Gln Ala Ala Val 
945                 950                 955                 960 


Pro Lys Gly Asp Asn Val Lys Ala Phe Ala Lys Asp Tyr Phe Thr His 
                965                 970                 975     


Glu Val Tyr Thr Gly Glu Val His Asp Gly Val Ala Thr Phe His Ile 
            980                 985                 990         


His Thr Ser Val Asn Lys Asp Ala  Ala Thr Gly Ile Asn  Leu Arg Ala 
        995                 1000                 1005             


Leu Leu  Gln Gly Trp Val Glu  Ile Asp Gly Pro Thr  Phe Asn Ala 
    1010                 1015                 1020             


Lys Gln  Val Thr Asp Pro Ser  Pro Ile Asn Asp Ala  Asn Tyr Leu 
    1025                 1030                 1035             


Gly Val  Tyr Tyr Asn Pro Asn  Ala Glu Glu Arg Lys  Asn Tyr Asp 
    1040                 1045                 1050             


Asn Arg  Asp Asp Leu Gly Val  Asp Phe Glu Asp Glu  Ala Ala Asp 
    1055                 1060                 1065             


Thr Asn  Thr Phe Gly Pro Gly  Asn His Ser Ser Ala  Lys Asp Asp 
    1070                 1075                 1080             


Ala Lys  Ile His Phe Asp Tyr  Leu Asn Asn Asn Asp  Ile Ser Thr 
    1085                 1090                 1095             


Leu Gly  Asn Lys Ala Val Glu  Lys Gly Tyr Tyr Asn  Pro Ala Thr 
    1100                 1105                 1110             


His Lys  Phe Thr Leu Thr Gly  Arg Val Asn Pro Glu  Val Ile Ser 
    1115                 1120                 1125             


Leu Thr  Phe Leu Ala Asp Ser  Pro Tyr Glu Val Asp  Pro Glu Asn 
    1130                 1135                 1140             


Gln Ala  Asp Ile His Asp Asn  Gly Lys Phe Ser Val  Thr Phe Thr 
    1145                 1150                 1155             


Ile Asp  Asn Pro Ala Thr Arg  Gln Leu Ser Tyr Phe  Phe Lys Thr 
    1160                 1165                 1170             


Asn Asp  Gly Lys Thr Thr Arg  Gly Ser Leu Thr Leu  Ile Leu Asp 
    1175                 1180                 1185             


Thr Val  Asp Pro Thr Leu Thr  Val Asp Gln Leu Gly  Asp Lys Asp 
    1190                 1195                 1200             


Glu Ala  Glu Ile Thr Thr Asn  Lys Pro Thr Phe Lys  Leu Ser Gly 
    1205                 1210                 1215             


Glu Ala  Asn Asp Asn Ile Asp  Gly Tyr Asn Val Phe  Ile Asn Gly 
    1220                 1225                 1230             


Asp Asn  Val Phe Gly Gln Phe  Gly Asn Ser Gly Tyr  Asp Phe Leu 
    1235                 1240                 1245             


Pro Gly  Ile Tyr Asn Asp Leu  Asn Gln Asn Thr Pro  Asn Leu Tyr 
    1250                 1255                 1260             


Gly Ser  Tyr Lys Phe Asp Gln  Glu Glu Gln Leu Asp  Asp Gln Asn 
    1265                 1270                 1275             


Gly Gln  Pro Thr Thr His Val  Phe Thr Ile Ala Val  Glu Asp Gln 
    1280                 1285                 1290             


Ala Gly  Asn Arg Val Glu Lys  Lys Val Thr Val His  Tyr Asp Pro 
    1295                 1300                 1305             


Asn Tyr  Leu Thr Glu Pro Val  Asn Thr Gly Lys Lys  Asp Asp Gln 
    1310                 1315                 1320             


Ala Asp  Val Lys Pro Ala Glu  Gly Gln Lys Gln Asp  Lys Asn Asp 
    1325                 1330                 1335             


Asn Gln  Thr Val Asn Asn Ser  Lys Glu Asp Pro Glu  Ser Gly Gln 
    1340                 1345                 1350             


Thr Thr  Glu Asn Ala Gln Ser  Thr Glu Ser Gln Glu  Gln Asn Lys 
    1355                 1360                 1365             


Thr Asp  Val Thr Lys Pro Ala  Ala Lys Pro Ser Asn  Asp Asp Gln 
    1370                 1375                 1380             


Lys Glu  Asn His Gly Ala Gly  Glu Ser Thr Ile Glu  Ser Asn Gln 
    1385                 1390                 1395             


Glu Lys  Gln Leu Gly Gln Ser  Asn Val Gln Ala Gln  Asp Thr Lys 
    1400                 1405                 1410             


Pro Asp  Lys Thr Val Val Gln  Gly Asn Val Gln Asn  Thr Ala Pro 
    1415                 1420                 1425             


Thr Thr  Gly His Leu Thr Asn  Ser Ser Val Asn Val  Gln Gln Phe 
    1430                 1435                 1440             


Lys Thr  Lys Lys Glu Thr Leu  Gln Leu Lys Lys Phe  Lys Leu Leu 
    1445                 1450                 1455             


Lys Asn  Thr Tyr Gly Tyr Thr  Leu Asn Gly Lys Ile  Ala Lys Lys 
    1460                 1465                 1470             


His Gly  Lys Lys Leu Leu Phe  Asn Lys Gly Lys Thr  Val Leu Val 
    1475                 1480                 1485             


Trp Asn  Asn Arg Lys Val Val  Thr Ile Lys Gly Gln  Lys Tyr Tyr 
    1490                 1495                 1500             


Arg Val  Ala Lys Asn Val Phe  Val Lys Val Ser Thr  Ile Lys Gln 
    1505                 1510                 1515             


Val Lys  Asp Leu Lys Leu Val  Leu Thr Lys Asn Ser  Tyr Val Tyr 
    1520                 1525                 1530             


Asn Lys  Leu Gly Lys Arg Val  Lys Tyr Lys Ser Gln  Ser Leu Ile 
    1535                 1540                 1545             


Lys Glu  Gly Lys His Leu Ser  Thr His Gln 
    1550                 1555             


<210>  43
<211>  1494
<212>  PRT
<213>  Lactobacillus rhamnosus

<400>  43

Met Asn Lys Asn Ala Thr Ile Glu Ala Lys Arg His Tyr Lys Met Tyr 
1               5                   10                  15      


Lys Ala Gly Ser Arg Trp Met Thr Ala Ala Ile Ile Thr Phe Gly Thr 
            20                  25                  30          


Ser Leu Val Val Leu Gly Gly Thr Ala Thr Gln Ser Val Ser Ala Asp 
        35                  40                  45              


Thr Lys Thr Pro Thr Ala Asp Lys Thr Thr Gln Pro Val Asn Gln Ala 
    50                  55                  60                  


Gln Thr Gln Thr Ala Thr Ser Thr Ala Ser Ser Gln Ala Thr Thr Ala 
65                  70                  75                  80  


Asp Ala Lys Asp Lys Thr Ala Glu Thr Gln Pro Thr Thr Thr Thr Thr 
                85                  90                  95      


Thr Lys Gln Val Thr Ala Gln Ser Gln Ala Ala Pro Ser Thr Ala Thr 
            100                 105                 110         


Lys Ala Gln Ser Gln Ala Ser Thr Thr Asn Gln Ala Gln Pro Ala Ala 
        115                 120                 125             


Ala Thr Lys Val Gln Thr Gly Thr Pro Ser Ser Gly Ala Asn Thr Gln 
    130                 135                 140                 


Pro Ala Ala Asn Thr Ala Thr Thr Lys Ser Ala Thr Ser Thr Thr Ser 
145                 150                 155                 160 


Ser Ala Ala Thr Gln Ser Ala Ala Pro Ala Ser Asn Ala Ala Thr Thr 
                165                 170                 175     


Asn Ala Ala Lys Thr Gln Ser Thr Ala Ala Thr Thr Thr Asp Pro Gly 
            180                 185                 190         


Pro Ala Asn Gln Asp Thr Leu Thr Lys Gly Asn Val Lys Gly Leu Trp 
        195                 200                 205             


Asn Glu Gly Tyr Gln Gly Gln Gly Met Val Val Ala Val Ile Asp Ser 
    210                 215                 220                 


Gly Val Gln Ala His Asp Asp Leu Arg Leu Ser Asp Asp Ser Thr Ala 
225                 230                 235                 240 


Ala Ile Thr Lys Glu Lys Ala Glu Ala Ala Ile Ser Lys Leu Gly Tyr 
                245                 250                 255     


Gly Ser Tyr Val Asn Ser Lys Ile Pro Phe Ala Tyr Asp Tyr Val Asn 
            260                 265                 270         


Asn Asp Ser Val Asn Thr Gly Thr Thr Val Ala Gly Ser Thr His Gly 
        275                 280                 285             


Glu His Val Ala Gly Ile Ile Ala Ala Asn Gly Thr Thr Ala Asp Gly 
    290                 295                 300                 


Ala Thr Gly Asn Glu Lys Ala Thr Thr Tyr Val Lys Gly Val Ala Pro 
305                 310                 315                 320 


Glu Ala Gln Ile Leu Ala Met Gln Val Ile Asp Glu Phe Ala Asp Glu 
                325                 330                 335     


Asn Ala Asn Asp Ile Ser Arg Ala Ile Arg Asp Ala Val Thr Leu Gly 
            340                 345                 350         


Ala Asn Ala Ile Gln Met Ser Leu Gly Ile Gly Val Thr Glu Gln Asp 
        355                 360                 365             


Leu Thr Asp Glu Glu Gln Ala Ala Val Gln Tyr Ala Thr Asp His Gly 
    370                 375                 380                 


Val Phe Val Ser Ile Ser Ala Gly Asn Asn Ala Asn Ala Gly Ser Ile 
385                 390                 395                 400 


Ile Gly Ser Lys Thr Ser Asn Asp Ile Ser Thr Ala Tyr Ser Pro Lys 
                405                 410                 415     


Asn Asp Ser Thr Ile Gly Asp Pro Gly Ala Ala Ala Ser Ala Met Thr 
            420                 425                 430         


Val Ala Ala Glu Lys Ser Ala Thr Gly Asp Lys Ser Glu Met Asp Gly 
        435                 440                 445             


Phe Ser Ser Trp Gly Pro Met Ala Asp Tyr Thr Leu Lys Pro Asp Ile 
    450                 455                 460                 


Ser Ala Pro Gly Asp Asn Val Ile Ser Thr Ala Ile Asp Pro Thr Thr 
465                 470                 475                 480 


Asn Thr Gln Thr Tyr Ala Thr Glu Ser Gly Thr Ser Met Ala Gly Pro 
                485                 490                 495     


Tyr Asn Ala Gly Ala Ala Leu Leu Val Met Gln Lys Ile Lys Ala Thr 
            500                 505                 510         


Arg Pro Asp Leu Gln Gly Ala Asp Leu Val Lys Ala Val Lys Leu Ala 
        515                 520                 525             


Leu Met Asn Ala Ala Asp Pro Met Lys Asp Ile Asn Tyr Pro Asp Thr 
    530                 535                 540                 


Tyr Ile Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Ser Lys 
545                 550                 555                 560 


Ala Gly Asp Leu Thr Val Ser Ala Glu Gly Asn Lys Asp Ala Gly Ser 
                565                 570                 575     


Val Ser Leu Gly Lys Ile Gly Gln Thr Thr Ser Phe Thr Val Thr Leu 
            580                 585                 590         


Thr Asn His Gly Lys Thr Ala Gln Asn Tyr Val Val Asp Thr Asn Gly 
        595                 600                 605             


Gly Pro Leu Thr Gln Val Gln Asp Thr Ser Asn Gly Asn Thr Val His 
    610                 615                 620                 


Asp Gln Thr Leu Ile Gly Ala Thr Val Asn Thr Asp Thr Ala Asn Phe 
625                 630                 635                 640 


Thr Leu Ala Ala Gly Glu Thr Lys Thr Val Thr Phe Lys Leu Ser Leu 
                645                 650                 655     


Asp Asn Thr Val Ala Ala Asn Gln Leu Val Glu Gly Phe Leu Thr Phe 
            660                 665                 670         


Lys Ala Gly Asp Thr Ser Gln Thr Ile Ser Val Pro Tyr Leu Gly Tyr 
        675                 680                 685             


Tyr Gly Asp Leu Thr Thr Glu Gln Val Val Asp Ala Ser Ala Asn Ser 
    690                 695                 700                 


Gly Glu Ser Ile Phe Asn Gly Gly Tyr Leu Val Asp Gly Ala Asn Thr 
705                 710                 715                 720 


Pro Leu Gly Val Thr Asp Ser Ala Ser Leu Ser Ser Leu Val Asn Thr 
                725                 730                 735     


Asp Thr Thr Gly Lys Tyr Thr Trp Thr Leu Val Pro Thr Tyr Val Asp 
            740                 745                 750         


Asn Lys Lys Val Ser Phe Ser Pro Asn Gly Asp Gly Ala Ser Asp Thr 
        755                 760                 765             


Val Tyr Pro Tyr Val Phe Ser Lys Gln Asn Leu Lys Ser Val Thr Ile 
    770                 775                 780                 


Gln Ile Leu Asp Ala Gln Gly His Val Val Arg Val Leu Asp Lys Glu 
785                 790                 795                 800 


Asn Asn Thr Thr Lys Ser Tyr Leu Gln Asn Gly Asn Ser Tyr Asn Ser 
                805                 810                 815     


Asp Leu Gly Leu Ser Thr Asp Met Arg Leu Asp Pro Asn Ala Phe Thr 
            820                 825                 830         


Trp Asp Gly Lys Val Tyr Asp Gln Ala Thr Gly Lys Tyr Val Thr Ala 
        835                 840                 845             


Pro Asp Gly Lys Tyr Thr Tyr Arg Leu Val Thr Glu Gln Tyr Asn Thr 
    850                 855                 860                 


Gly Ala Gln Gln Asn Gln Asp Phe Asp Leu Pro Val Thr Val Asp Thr 
865                 870                 875                 880 


Val Ala Pro Thr Leu Thr Gly Leu Ser Tyr Gln Asn Gly Arg Val Thr 
                885                 890                 895     


Val Asn Tyr Asn Asp Gln Gly Ala Gly Phe Thr Lys Phe Ser Asp Ile 
            900                 905                 910         


Ala Leu Lys Ile Gly Gly Lys Ala Tyr Gly Val Ser Leu Asn Asn Asn 
        915                 920                 925             


Gly Gln Asn Asn Asp Gly Thr Leu Ser Phe Asp Leu Thr Ala Ala Gln 
    930                 935                 940                 


Lys Ala Ala Leu Glu Ser Ser Asp Gly Ser Leu Thr Leu Thr Leu Thr 
945                 950                 955                 960 


Asp Val Ala Gly Asn Lys Thr Ser Lys Thr Leu Gln Ala Val Thr Gly 
                965                 970                 975     


Thr His Gln Ala Thr Thr Pro Thr Ala Thr Thr Ala Asn Val Ala Pro 
            980                 985                 990         


Gln Phe Ser Trp Lys Val Gly Asp  Gly Pro Tyr Asn His  Trp Arg Thr 
        995                 1000                 1005             


Asp Gly  Phe Val Gln Ala Val  Ser Asp Gln Thr Ser  Phe Thr Ala 
    1010                 1015                 1020             


Tyr Ala  Gln Val Pro Ala Gly  Val Asp Trp Ile Val  Tyr Ala Thr 
    1025                 1030                 1035             


Asp Ala  Met Thr Gly Lys Val  Phe Ser Gly Lys Val  Asp Thr Lys 
    1040                 1045                 1050             


Thr Gly  Asn Val Thr Phe Asn  Leu Thr Ala Ser Ala  Pro Tyr Gly 
    1055                 1060                 1065             


Asp Phe  Val Gly Thr Val Leu  Ala Pro Thr Ala Asp  Phe Gly Thr 
    1070                 1075                 1080             


Tyr Glu  Gln Ala Gly Arg Ala  Asn Gly Asp Glu Met  Val Val Phe 
    1085                 1090                 1095             


Leu Asp  Thr Asp Gly Thr Ala  Gly Tyr Gly His Phe  Ser Gln Lys 
    1100                 1105                 1110             


Asp Pro  His Val Ala Val Pro  Leu Gln Asp Asn Ala  Lys Ala Ala 
    1115                 1120                 1125             


Ala Asn  Val Lys Thr Thr Ser  Gly Ala Pro Val Leu  Gly Gly Arg 
    1130                 1135                 1140             


Ala Phe  Ser Gln Ile Thr Thr  His Ala Gln Pro Thr  Ala Gly Leu 
    1145                 1150                 1155             


Thr Phe  Asp Lys Phe Asn Asp  Asn Ser Phe Thr Leu  Val Gly Ala 
    1160                 1165                 1170             


Asp Lys  Val Ala Asp Ile Tyr  Asn Ala Lys Thr Gly  Gln Leu Thr 
    1175                 1180                 1185             


Ile Thr  Gly His Val Asp Gln  Pro Ala Gly Lys Thr  Leu Thr Val 
    1190                 1195                 1200             


Thr Ser  Ala Thr Glu Pro Ala  Lys Thr Val Thr Ile  Gly Ala Asp 
    1205                 1210                 1215             


Gly Lys  Phe Ser Phe Thr Val  Pro Phe Lys Ala Ala  Glu Gln Gln 
    1220                 1225                 1230             


Ala Ile  Gly Tyr Arg Leu Thr  Ser Pro Ala Thr Asp  Gly Ser Lys 
    1235                 1240                 1245             


Ser Thr  Gln Thr Ala Tyr Gly  Glu Leu Gln Ile Tyr  Leu Asp Thr 
    1250                 1255                 1260             


Ile Phe  Pro Thr Leu Asn Met  Pro Gln Ala Asp Thr  Leu Gln Val 
    1265                 1270                 1275             


Asp Asp  Lys Gly Asn Tyr Glu  Ile Thr Thr Thr Ser  Asp Thr Phe 
    1280                 1285                 1290             


Thr Val  Ser Gly Thr Val Asn  Asp Asn Ile Asn Gly  Tyr Arg Leu 
    1295                 1300                 1305             


Tyr Thr  Asn Gly Asp Asn Ile  Val His Gln Lys Asn  Leu Ala Gly 
    1310                 1315                 1320             


Phe Asn  Asn His Leu Asp Pro  Leu Ser Thr Thr Ser  Asn Pro Tyr 
    1325                 1330                 1335             


Gly Ala  Ala Ala Phe Thr Gln  Thr Tyr Gln Leu Ala  Asp Gly Asp 
    1340                 1345                 1350             


Asn Tyr  Phe Thr Ile Thr Ala  Val Asp Met Val Gly  Asn Lys Val 
    1355                 1360                 1365             


Thr Lys  Val Phe His Val Ile  Lys Thr Lys Ala Thr  Thr Pro Thr 
    1370                 1375                 1380             


Thr Pro  Glu Thr Pro Lys Thr  Pro Thr Pro Thr Pro  Lys Pro Gly 
    1385                 1390                 1395             


Thr Gly  Asp Gln Thr Asp Thr  Lys Asn Pro Lys Gly  Pro Thr Thr 
    1400                 1405                 1410             


Thr Pro  Lys Thr Asp Glu Gln  Gly Lys Thr Asn Pro  Thr Pro Lys 
    1415                 1420                 1425             


Phe Val  Asp Leu Thr Asn Thr  Thr Lys Gly Gln Asp  Lys Thr Gly 
    1430                 1435                 1440             


Thr Thr  Ala Glu Thr Gly Lys  Asn Thr Lys Gln Thr  Ala Ala Ala 
    1445                 1450                 1455             


Lys Thr  Met Pro Gln Ala Gly  Glu Ala Gln Ser Pro  Leu Ala Val 
    1460                 1465                 1470             


Leu Gly  Leu Ala Ile Leu Ser  Met Leu Gly Leu Ala  Gly Phe Val 
    1475                 1480                 1485             


Ser Arg  Lys Lys Arg Val 
    1490                 


<210>  44
<211>  1443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Lactobacillus rhamnosus ATCC 21052 protease

<400>  44

Pro Thr Ala Asp Lys Thr Thr Gln Pro Val Asn Gln Ala Gln Thr Gln 
1               5                   10                  15      


Thr Ala Thr Ser Thr Ala Ser Ser Gln Ala Thr Thr Ala Asp Ala Lys 
            20                  25                  30          


Asp Lys Thr Ala Glu Thr Gln Pro Thr Thr Thr Thr Thr Thr Lys Gln 
        35                  40                  45              


Val Thr Ala Gln Ser Gln Ala Ala Pro Ser Thr Ala Thr Lys Ala Gln 
    50                  55                  60                  


Ser Gln Ala Ser Thr Thr Asn Gln Ala Gln Pro Ala Ala Ala Thr Lys 
65                  70                  75                  80  


Val Gln Thr Gly Thr Pro Ser Ser Gly Ala Asn Thr Gln Pro Ala Ala 
                85                  90                  95      


Asn Thr Ala Thr Thr Lys Ser Ala Thr Ser Thr Thr Ser Ser Ala Ala 
            100                 105                 110         


Thr Gln Ser Ala Ala Pro Ala Ser Asn Ala Ala Thr Thr Asn Ala Ala 
        115                 120                 125             


Lys Thr Gln Ser Thr Ala Ala Thr Thr Thr Asp Pro Gly Pro Ala Asn 
    130                 135                 140                 


Gln Asp Thr Leu Thr Lys Gly Asn Val Lys Gly Leu Trp Asn Glu Gly 
145                 150                 155                 160 


Tyr Gln Gly Gln Gly Met Val Val Ala Val Ile Asp Ser Gly Val Gln 
                165                 170                 175     


Ala His Asp Asp Leu Arg Leu Ser Asp Asp Ser Thr Ala Ala Ile Thr 
            180                 185                 190         


Lys Glu Lys Ala Glu Ala Ala Ile Ser Lys Leu Gly Tyr Gly Ser Tyr 
        195                 200                 205             


Val Asn Ser Lys Ile Pro Phe Ala Tyr Asp Tyr Val Asn Asn Asp Ser 
    210                 215                 220                 


Val Asn Thr Gly Thr Thr Val Ala Gly Ser Thr His Gly Glu His Val 
225                 230                 235                 240 


Ala Gly Ile Ile Ala Ala Asn Gly Thr Thr Ala Asp Gly Ala Thr Gly 
                245                 250                 255     


Asn Glu Lys Ala Thr Thr Tyr Val Lys Gly Val Ala Pro Glu Ala Gln 
            260                 265                 270         


Ile Leu Ala Met Gln Val Ile Asp Glu Phe Ala Asp Glu Asn Ala Asn 
        275                 280                 285             


Asp Ile Ser Arg Ala Ile Arg Asp Ala Val Thr Leu Gly Ala Asn Ala 
    290                 295                 300                 


Ile Gln Met Ser Leu Gly Ile Gly Val Thr Glu Gln Asp Leu Thr Asp 
305                 310                 315                 320 


Glu Glu Gln Ala Ala Val Gln Tyr Ala Thr Asp His Gly Val Phe Val 
                325                 330                 335     


Ser Ile Ser Ala Gly Asn Asn Ala Asn Ala Gly Ser Ile Ile Gly Ser 
            340                 345                 350         


Lys Thr Ser Asn Asp Ile Ser Thr Ala Tyr Ser Pro Lys Asn Asp Ser 
        355                 360                 365             


Thr Ile Gly Asp Pro Gly Ala Ala Ala Ser Ala Met Thr Val Ala Ala 
    370                 375                 380                 


Glu Lys Ser Ala Thr Gly Asp Lys Ser Glu Met Asp Gly Phe Ser Ser 
385                 390                 395                 400 


Trp Gly Pro Met Ala Asp Tyr Thr Leu Lys Pro Asp Ile Ser Ala Pro 
                405                 410                 415     


Gly Asp Asn Val Ile Ser Thr Ala Ile Asp Pro Thr Thr Asn Thr Gln 
            420                 425                 430         


Thr Tyr Ala Thr Glu Ser Gly Thr Ser Met Ala Gly Pro Tyr Asn Ala 
        435                 440                 445             


Gly Ala Ala Leu Leu Val Met Gln Lys Ile Lys Ala Thr Arg Pro Asp 
    450                 455                 460                 


Leu Gln Gly Ala Asp Leu Val Lys Ala Val Lys Leu Ala Leu Met Asn 
465                 470                 475                 480 


Ala Ala Asp Pro Met Lys Asp Ile Asn Tyr Pro Asp Thr Tyr Ile Ser 
                485                 490                 495     


Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Ser Lys Ala Gly Asp 
            500                 505                 510         


Leu Thr Val Ser Ala Glu Gly Asn Lys Asp Ala Gly Ser Val Ser Leu 
        515                 520                 525             


Gly Lys Ile Gly Gln Thr Thr Ser Phe Thr Val Thr Leu Thr Asn His 
    530                 535                 540                 


Gly Lys Thr Ala Gln Asn Tyr Val Val Asp Thr Asn Gly Gly Pro Leu 
545                 550                 555                 560 


Thr Gln Val Gln Asp Thr Ser Asn Gly Asn Thr Val His Asp Gln Thr 
                565                 570                 575     


Leu Ile Gly Ala Thr Val Asn Thr Asp Thr Ala Asn Phe Thr Leu Ala 
            580                 585                 590         


Ala Gly Glu Thr Lys Thr Val Thr Phe Lys Leu Ser Leu Asp Asn Thr 
        595                 600                 605             


Val Ala Ala Asn Gln Leu Val Glu Gly Phe Leu Thr Phe Lys Ala Gly 
    610                 615                 620                 


Asp Thr Ser Gln Thr Ile Ser Val Pro Tyr Leu Gly Tyr Tyr Gly Asp 
625                 630                 635                 640 


Leu Thr Thr Glu Gln Val Val Asp Ala Ser Ala Asn Ser Gly Glu Ser 
                645                 650                 655     


Ile Phe Asn Gly Gly Tyr Leu Val Asp Gly Ala Asn Thr Pro Leu Gly 
            660                 665                 670         


Val Thr Asp Ser Ala Ser Leu Ser Ser Leu Val Asn Thr Asp Thr Thr 
        675                 680                 685             


Gly Lys Tyr Thr Trp Thr Leu Val Pro Thr Tyr Val Asp Asn Lys Lys 
    690                 695                 700                 


Val Ser Phe Ser Pro Asn Gly Asp Gly Ala Ser Asp Thr Val Tyr Pro 
705                 710                 715                 720 


Tyr Val Phe Ser Lys Gln Asn Leu Lys Ser Val Thr Ile Gln Ile Leu 
                725                 730                 735     


Asp Ala Gln Gly His Val Val Arg Val Leu Asp Lys Glu Asn Asn Thr 
            740                 745                 750         


Thr Lys Ser Tyr Leu Gln Asn Gly Asn Ser Tyr Asn Ser Asp Leu Gly 
        755                 760                 765             


Leu Ser Thr Asp Met Arg Leu Asp Pro Asn Ala Phe Thr Trp Asp Gly 
    770                 775                 780                 


Lys Val Tyr Asp Gln Ala Thr Gly Lys Tyr Val Thr Ala Pro Asp Gly 
785                 790                 795                 800 


Lys Tyr Thr Tyr Arg Leu Val Thr Glu Gln Tyr Asn Thr Gly Ala Gln 
                805                 810                 815     


Gln Asn Gln Asp Phe Asp Leu Pro Val Thr Val Asp Thr Val Ala Pro 
            820                 825                 830         


Thr Leu Thr Gly Leu Ser Tyr Gln Asn Gly Arg Val Thr Val Asn Tyr 
        835                 840                 845             


Asn Asp Gln Gly Ala Gly Phe Thr Lys Phe Ser Asp Ile Ala Leu Lys 
    850                 855                 860                 


Ile Gly Gly Lys Ala Tyr Gly Val Ser Leu Asn Asn Asn Gly Gln Asn 
865                 870                 875                 880 


Asn Asp Gly Thr Leu Ser Phe Asp Leu Thr Ala Ala Gln Lys Ala Ala 
                885                 890                 895     


Leu Glu Ser Ser Asp Gly Ser Leu Thr Leu Thr Leu Thr Asp Val Ala 
            900                 905                 910         


Gly Asn Lys Thr Ser Lys Thr Leu Gln Ala Val Thr Gly Thr His Gln 
        915                 920                 925             


Ala Thr Thr Pro Thr Ala Thr Thr Ala Asn Val Ala Pro Gln Phe Ser 
    930                 935                 940                 


Trp Lys Val Gly Asp Gly Pro Tyr Asn His Trp Arg Thr Asp Gly Phe 
945                 950                 955                 960 


Val Gln Ala Val Ser Asp Gln Thr Ser Phe Thr Ala Tyr Ala Gln Val 
                965                 970                 975     


Pro Ala Gly Val Asp Trp Ile Val Tyr Ala Thr Asp Ala Met Thr Gly 
            980                 985                 990         


Lys Val Phe Ser Gly Lys Val Asp  Thr Lys Thr Gly Asn  Val Thr Phe 
        995                 1000                 1005             


Asn Leu  Thr Ala Ser Ala Pro  Tyr Gly Asp Phe Val  Gly Thr Val 
    1010                 1015                 1020             


Leu Ala  Pro Thr Ala Asp Phe  Gly Thr Tyr Glu Gln  Ala Gly Arg 
    1025                 1030                 1035             


Ala Asn  Gly Asp Glu Met Val  Val Phe Leu Asp Thr  Asp Gly Thr 
    1040                 1045                 1050             


Ala Gly  Tyr Gly His Phe Ser  Gln Lys Asp Pro His  Val Ala Val 
    1055                 1060                 1065             


Pro Leu  Gln Asp Asn Ala Lys  Ala Ala Ala Asn Val  Lys Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ala Pro Val Leu Gly  Gly Arg Ala Phe Ser  Gln Ile Thr 
    1085                 1090                 1095             


Thr His  Ala Gln Pro Thr Ala  Gly Leu Thr Phe Asp  Lys Phe Asn 
    1100                 1105                 1110             


Asp Asn  Ser Phe Thr Leu Val  Gly Ala Asp Lys Val  Ala Asp Ile 
    1115                 1120                 1125             


Tyr Asn  Ala Lys Thr Gly Gln  Leu Thr Ile Thr Gly  His Val Asp 
    1130                 1135                 1140             


Gln Pro  Ala Gly Lys Thr Leu  Thr Val Thr Ser Ala  Thr Glu Pro 
    1145                 1150                 1155             


Ala Lys  Thr Val Thr Ile Gly  Ala Asp Gly Lys Phe  Ser Phe Thr 
    1160                 1165                 1170             


Val Pro  Phe Lys Ala Ala Glu  Gln Gln Ala Ile Gly  Tyr Arg Leu 
    1175                 1180                 1185             


Thr Ser  Pro Ala Thr Asp Gly  Ser Lys Ser Thr Gln  Thr Ala Tyr 
    1190                 1195                 1200             


Gly Glu  Leu Gln Ile Tyr Leu  Asp Thr Ile Phe Pro  Thr Leu Asn 
    1205                 1210                 1215             


Met Pro  Gln Ala Asp Thr Leu  Gln Val Asp Asp Lys  Gly Asn Tyr 
    1220                 1225                 1230             


Glu Ile  Thr Thr Thr Ser Asp  Thr Phe Thr Val Ser  Gly Thr Val 
    1235                 1240                 1245             


Asn Asp  Asn Ile Asn Gly Tyr  Arg Leu Tyr Thr Asn  Gly Asp Asn 
    1250                 1255                 1260             


Ile Val  His Gln Lys Asn Leu  Ala Gly Phe Asn Asn  His Leu Asp 
    1265                 1270                 1275             


Pro Leu  Ser Thr Thr Ser Asn  Pro Tyr Gly Ala Ala  Ala Phe Thr 
    1280                 1285                 1290             


Gln Thr  Tyr Gln Leu Ala Asp  Gly Asp Asn Tyr Phe  Thr Ile Thr 
    1295                 1300                 1305             


Ala Val  Asp Met Val Gly Asn  Lys Val Thr Lys Val  Phe His Val 
    1310                 1315                 1320             


Ile Lys  Thr Lys Ala Thr Thr  Pro Thr Thr Pro Glu  Thr Pro Lys 
    1325                 1330                 1335             


Thr Pro  Thr Pro Thr Pro Lys  Pro Gly Thr Gly Asp  Gln Thr Asp 
    1340                 1345                 1350             


Thr Lys  Asn Pro Lys Gly Pro  Thr Thr Thr Pro Lys  Thr Asp Glu 
    1355                 1360                 1365             


Gln Gly  Lys Thr Asn Pro Thr  Pro Lys Phe Val Asp  Leu Thr Asn 
    1370                 1375                 1380             


Thr Thr  Lys Gly Gln Asp Lys  Thr Gly Thr Thr Ala  Glu Thr Gly 
    1385                 1390                 1395             


Lys Asn  Thr Lys Gln Thr Ala  Ala Ala Lys Thr Met  Pro Gln Ala 
    1400                 1405                 1410             


Gly Glu  Ala Gln Ser Pro Leu  Ala Val Leu Gly Leu  Ala Ile Leu 
    1415                 1420                 1425             


Ser Met  Leu Gly Leu Ala Gly  Phe Val Ser Arg Lys  Lys Arg Val 
    1430                 1435                 1440             


<210>  45
<211>  1532
<212>  PRT
<213>  Lactobacillus sp. HMSC068F07

<400>  45

Met Asn Lys Asn Ser Thr Thr Glu Met Lys Arg His Tyr Lys Met Tyr 
1               5                   10                  15      


Lys Ala Gly Ser Lys Trp Met Thr Ala Ala Ile Ile Thr Phe Gly Thr 
            20                  25                  30          


Ser Leu Ile Val Leu Gly Gly Thr Ala Thr Gln Ser Val Ala Ala Asp 
        35                  40                  45              


Thr Thr Thr Thr Pro Thr Glu Lys Thr Ser Gln Thr Ala Gln Ser Thr 
    50                  55                  60                  


Ser Ala Gln Ser Gln Pro Ala Ala Gln Thr Thr Thr Ser Gln Ala Thr 
65                  70                  75                  80  


Ala Ser Asp Ala Thr Ser Ser Ala Thr Gln Thr Ala Ala Ala Asn Ser 
                85                  90                  95      


Ala Lys Ser Ser Thr Ala Gln Thr Gln Ala Ala Pro Ala Gln Asn Thr 
            100                 105                 110         


Gln Ser Ser Ala Ser Gln Pro Gln Ala Ala Thr Gln Gln Ala Ser Ser 
        115                 120                 125             


Ala Thr Ala Lys Thr Thr Ala Pro Ala Ser Gly Ala Thr Thr Gln Thr 
    130                 135                 140                 


Asn Thr Ser Ser Val Ala Ser Gln Ala Thr Thr Ser Thr Ala Thr Thr 
145                 150                 155                 160 


Ala Thr Ser Gln Ala Ser Ala Ala Ala Thr Ala Thr Ser Thr Ala Thr 
                165                 170                 175     


Ala Asp Asn Gln Ser Gln Ala Ser Ser Ala Ala Thr Thr Asp Pro Gly 
            180                 185                 190         


Pro Ala Asn Gln Asp Thr Leu Thr Lys Gly Asn Val Lys Gly Leu Trp 
        195                 200                 205             


Asp Glu Gly Tyr Gln Gly Gln Gly Met Val Val Ala Val Ile Asp Ser 
    210                 215                 220                 


Gly Val Gln Pro His Ala Asp Leu Arg Leu Ser Asp Asp Ser Thr Ala 
225                 230                 235                 240 


Thr Leu Thr Lys Glu Lys Ala Glu Ala Ala Ile Ala Lys Leu Gly Tyr 
                245                 250                 255     


Gly Thr Tyr Val Asn Ser Lys Ile Pro Phe Ala Tyr Asp Tyr Val Asn 
            260                 265                 270         


Asn Asp Ser Val Asn Thr Gly Thr Thr Val Ala Gly Ser Thr His Gly 
        275                 280                 285             


Glu His Val Ala Gly Ile Ile Ala Ala Asn Gly Thr Thr Ala Asp Gly 
    290                 295                 300                 


Ala Thr Gly Lys Glu Lys Ala Ser Thr Tyr Val Lys Gly Val Ala Pro 
305                 310                 315                 320 


Glu Ala Gln Ile Leu Ala Met Gln Val Ile Asp Glu Phe Pro Asp Glu 
                325                 330                 335     


Asn Ala Asn Asp Ile Ser Arg Ala Ile Arg Asp Ala Val Ala Leu Gly 
            340                 345                 350         


Ala Asn Ala Ile Gln Met Ser Leu Gly Ile Gly Val Thr Glu Gln Asp 
        355                 360                 365             


Leu Thr Asp Glu Glu Gln Ala Ala Val Gln Tyr Ala Thr Glu His Gly 
    370                 375                 380                 


Val Phe Val Ser Ile Ser Ala Gly Asn Asn Ala Ile Ala Gly Ser Ile 
385                 390                 395                 400 


Ile Gly Ser Lys Thr Pro Asn Asp Ile Ser Thr Ala Tyr Ala Pro Lys 
                405                 410                 415     


Asn Asp Ser Thr Ile Gly Asp Pro Gly Ala Ala Ala Ser Ala Met Thr 
            420                 425                 430         


Val Ala Ala Glu Thr Ser Ala Thr Gly Ala Asp Ser Gln Met Asp Gly 
        435                 440                 445             


Phe Ser Ser Trp Gly Pro Met Ala Asp Tyr Thr Leu Lys Pro Asp Ile 
    450                 455                 460                 


Ser Ala Pro Gly Asp Asn Val Thr Ser Thr Ala Ile Asp Pro Ala Thr 
465                 470                 475                 480 


Asn Thr Gln Thr Tyr Ala Val Glu Ser Gly Thr Ser Met Ala Gly Pro 
                485                 490                 495     


Phe Asn Ala Gly Ala Ala Leu Leu Val Met Gln Lys Ile Lys Ala Thr 
            500                 505                 510         


Gln Pro Asp Leu Thr Gly Ala Asp Leu Val Lys Ala Val Lys Leu Ala 
        515                 520                 525             


Leu Met Asn Ala Ala Glu Pro Met Lys Asp Ile Asn Tyr Pro Asp Thr 
    530                 535                 540                 


Tyr Ile Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Ala Lys 
545                 550                 555                 560 


Ala Gly Asp Leu Thr Val Thr Ala Glu Gly Ser Asn Asp Ala Gly Ser 
                565                 570                 575     


Val Ser Leu Gly Lys Ile Gly Lys Thr Thr Thr Phe Thr Val Thr Leu 
            580                 585                 590         


Thr Asn His Gly Lys Thr Ala Gln Asn Tyr Thr Val Asp Thr Asn Gly 
        595                 600                 605             


Gly Pro Leu Thr Gln Val Arg Asp Ala Ser Asn Gly Asn Thr Val His 
    610                 615                 620                 


Asp Glu Thr Leu Val Gly Ala Thr Val Asn Thr Asp Thr Ala Asn Phe 
625                 630                 635                 640 


Thr Leu Ala Ala Gly Glu Thr Lys Lys Val Thr Phe Lys Leu Ser Leu 
                645                 650                 655     


Asp Asp Ser Val Ala Ala Asn Gln Leu Val Glu Gly Tyr Leu Thr Phe 
            660                 665                 670         


Lys Ala Thr Asp Ala Ala Gln Thr Ile Ser Val Pro Tyr Leu Gly Tyr 
        675                 680                 685             


Tyr Gly Asp Leu Thr Asp Glu Gln Val Ile Asp Ala Pro Ala Asn Ser 
    690                 695                 700                 


Gly Glu Ser Ile Phe Asn Gly Gly Tyr Leu Val Asp Asn Asn Asn Asn 
705                 710                 715                 720 


Pro Leu Gly Val Thr Asp Ala Ala Ser Leu Ser Asn Leu Val Asn Thr 
                725                 730                 735     


Asp Thr Thr Gly Lys Tyr Thr Trp Thr Leu Val Pro Thr Tyr Val Asp 
            740                 745                 750         


Asn Lys Lys Val Ser Phe Ser Pro Asn Gly Asp Gly Ala Ser Asp Thr 
        755                 760                 765             


Val Phe Pro Tyr Val Phe Ser Lys Gln Asn Leu Lys Ser Val Thr Ile 
    770                 775                 780                 


Gln Ile Leu Asp Ala Gln Gly His Val Val Arg Ile Leu Asp Lys Glu 
785                 790                 795                 800 


Asn Asn Thr Ser Lys Ser Tyr Leu Gln Asn Gly Asn Ser Phe Asn Ser 
                805                 810                 815     


Asp Leu Gly Leu Ser Thr Asp Met Arg Leu Asp Pro Asn Ala Phe Thr 
            820                 825                 830         


Trp Asp Gly Lys Val Tyr Asp Gln Ala Thr Gly Lys Tyr Val Thr Ala 
        835                 840                 845             


Pro Asp Gly Lys Tyr Thr Tyr Arg Leu Val Thr Glu Gln Tyr Asn Thr 
    850                 855                 860                 


Gly Ala Gln Gln Asn Gln Asp Tyr Asp Leu Pro Val Thr Val Asp Thr 
865                 870                 875                 880 


Val Ala Pro Thr Leu Thr Gly Leu Ser Tyr Gln Asp Gly Arg Val Ser 
                885                 890                 895     


Val His Tyr Asp Asp Gln Gly Ala Gly Phe Thr Lys Phe Ser Asp Leu 
            900                 905                 910         


Ala Leu Lys Ile Gly Asn Lys Ala Tyr Gly Val Asn Leu Asn Asn Asn 
        915                 920                 925             


Gly Gln Asn Asn Asp Gly Thr Leu Ser Phe Glu Leu Thr Ala Ala Gln 
    930                 935                 940                 


Lys Ala Ala Leu Glu Asn Ser Asp Gly Ser Leu Thr Leu Thr Leu Thr 
945                 950                 955                 960 


Asp Val Ala Gly Asn Lys Thr Ser Ala Ser Leu Gln Ala Thr Ala Gly 
                965                 970                 975     


Thr His Gln Thr Asp Thr Thr Thr Pro Thr Ser Asp Val Ala Pro Gln 
            980                 985                 990         


Phe Thr Trp Lys Val Gly Asp Gly  Pro His Asn Phe Trp  Arg Ser Glu 
        995                 1000                 1005             


Gly Phe  Val Gln Ala Val Ser  Asp Gln Thr Ser Phe  Thr Ala Tyr 
    1010                 1015                 1020             


Ala Gln  Val Pro Ala Gly Val  Asp Trp Ile Val Tyr  Ala Thr Asp 
    1025                 1030                 1035             


Ala Gln  Thr Gly Lys Val Phe  Pro Gly Thr Val Asp  Thr Lys Thr 
    1040                 1045                 1050             


Gly Thr  Val Thr Phe Asn Leu  Thr Glu Ser Ala Pro  Tyr Gly Asp 
    1055                 1060                 1065             


Phe Val  Gly Thr Val Leu Ser  Pro Thr Ala Asp Phe  Gly Thr Tyr 
    1070                 1075                 1080             


Glu Glu  Ala Gly Arg Ala Asp  Gly Asp Glu Met Ile  Val Phe Leu 
    1085                 1090                 1095             


Asp Ala  Asn Gly Thr Ala Gly  Tyr Gly His Phe Ser  Gln Lys Asn 
    1100                 1105                 1110             


Val His  Val Val Val Pro Leu  Gln Asp Asn Ala Lys  Ala Ala Ala 
    1115                 1120                 1125             


Asn Ala  Thr Lys Thr Ser Gly  Ala Pro Val Leu Gly  Gly Arg Ala 
    1130                 1135                 1140             


Phe Ser  Gln Ile Thr Thr His  Ala Gln Pro Thr Ala  Gly Leu Lys 
    1145                 1150                 1155             


Phe Asp  Lys Phe Asn Asp Asn  Ser Phe Thr Leu Val  Gly Ala Asp 
    1160                 1165                 1170             


Gln Val  Ala Asp Ile Tyr Asn  Ala Gln Thr Gly Gln  Leu Thr Ile 
    1175                 1180                 1185             


Thr Gly  His Val Asp Asn Pro  Ala Gly Lys Thr Leu  Thr Val Thr 
    1190                 1195                 1200             


Asp Ala  Thr Glu Pro Ala Lys  Thr Val Ala Ile Gly  Ala Asp Gly 
    1205                 1210                 1215             


Lys Phe  Ser Phe Thr Val Pro  Phe Lys Ala Ala Glu  Gln Gln Ser 
    1220                 1225                 1230             


Val Gly  Tyr Arg Leu Thr Glu  Pro Ala Thr Asp Gly  Ser Lys Ser 
    1235                 1240                 1245             


Thr Lys  Thr Ala Tyr Gly Glu  Leu Gln Ile Tyr Leu  Asp Thr Ile 
    1250                 1255                 1260             


Phe Pro  Thr Leu Asp Leu Pro  Gln Ala Asp Thr Leu  Lys Val Asp 
    1265                 1270                 1275             


Asp Gln  Gly Asn Tyr Asp Ile  Thr Thr Thr Ser Asp  Thr Phe Thr 
    1280                 1285                 1290             


Val Ser  Gly Thr Val Asn Asp  Asn Ile Asn Gly Tyr  Arg Leu Tyr 
    1295                 1300                 1305             


Thr Asn  Gly Asp Asn Val Val  His Gln Lys Asn Leu  Ala Gly Phe 
    1310                 1315                 1320             


Asn Asn  His Leu Asp Pro Gln  Ser Thr Thr Ser Asn  Pro Tyr Gly 
    1325                 1330                 1335             


Ala Ala  Asp Phe Asn Gln Thr  Tyr Thr Leu Lys Asp  Gly Asp Asn 
    1340                 1345                 1350             


Tyr Phe  Thr Val Thr Ala Val  Asp Met Val Gly Asn  Lys Val Thr 
    1355                 1360                 1365             


Lys Val  Phe His Val Val Lys  Val Lys Thr Pro Thr  Pro Thr Pro 
    1370                 1375                 1380             


Gly Asp  Asn Gly Asn Thr Ser  Gly Thr Asp Asn Ser  Gly Asn Gly 
    1385                 1390                 1395             


Asn Pro  Asn Gln Gln Gly Thr  Gly Gly Asn Ala Gly  Asn Gln Gly 
    1400                 1405                 1410             


Gly Asn  Ala Gly Asn Gln Gly  Asn Asn Gly Gly Thr  Gln Gly Gly 
    1415                 1420                 1425             


Asn Gly  Ser Gly Gln Thr Pro  Ala Thr Gly Asn Gly  Thr Pro Thr 
    1430                 1435                 1440             


Thr Pro  Thr Thr Gly Thr Gly  Thr Asn Gly Gly Asn  Gly Asn Asn 
    1445                 1450                 1455             


Arg Gln  Gln Ser Pro Glu Leu  Val Thr Leu Asp Asn  Lys Leu Lys 
    1460                 1465                 1470             


Asp Gln  Thr Lys Thr Pro Ala  Ala Lys Asn Gly Thr  Thr Ala Asn 
    1475                 1480                 1485             


Gly Thr  Lys Gln Ala Ala Thr  Gly Lys Thr Met Pro  Gln Ala Gly 
    1490                 1495                 1500             


Glu Ser  Gln Ser Pro Leu Ala  Val Ile Gly Leu Ala  Ile Val Ser 
    1505                 1510                 1515             


Ile Phe  Ser Phe Met Gly Phe  Ala Ser Arg Lys Lys  Arg Val 
    1520                 1525                 1530         


<210>  46
<211>  1481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Lactobacillus sp. HMSC068F07 protease

<400>  46

Thr Pro Thr Glu Lys Thr Ser Gln Thr Ala Gln Ser Thr Ser Ala Gln 
1               5                   10                  15      


Ser Gln Pro Ala Ala Gln Thr Thr Thr Ser Gln Ala Thr Ala Ser Asp 
            20                  25                  30          


Ala Thr Ser Ser Ala Thr Gln Thr Ala Ala Ala Asn Ser Ala Lys Ser 
        35                  40                  45              


Ser Thr Ala Gln Thr Gln Ala Ala Pro Ala Gln Asn Thr Gln Ser Ser 
    50                  55                  60                  


Ala Ser Gln Pro Gln Ala Ala Thr Gln Gln Ala Ser Ser Ala Thr Ala 
65                  70                  75                  80  


Lys Thr Thr Ala Pro Ala Ser Gly Ala Thr Thr Gln Thr Asn Thr Ser 
                85                  90                  95      


Ser Val Ala Ser Gln Ala Thr Thr Ser Thr Ala Thr Thr Ala Thr Ser 
            100                 105                 110         


Gln Ala Ser Ala Ala Ala Thr Ala Thr Ser Thr Ala Thr Ala Asp Asn 
        115                 120                 125             


Gln Ser Gln Ala Ser Ser Ala Ala Thr Thr Asp Pro Gly Pro Ala Asn 
    130                 135                 140                 


Gln Asp Thr Leu Thr Lys Gly Asn Val Lys Gly Leu Trp Asp Glu Gly 
145                 150                 155                 160 


Tyr Gln Gly Gln Gly Met Val Val Ala Val Ile Asp Ser Gly Val Gln 
                165                 170                 175     


Pro His Ala Asp Leu Arg Leu Ser Asp Asp Ser Thr Ala Thr Leu Thr 
            180                 185                 190         


Lys Glu Lys Ala Glu Ala Ala Ile Ala Lys Leu Gly Tyr Gly Thr Tyr 
        195                 200                 205             


Val Asn Ser Lys Ile Pro Phe Ala Tyr Asp Tyr Val Asn Asn Asp Ser 
    210                 215                 220                 


Val Asn Thr Gly Thr Thr Val Ala Gly Ser Thr His Gly Glu His Val 
225                 230                 235                 240 


Ala Gly Ile Ile Ala Ala Asn Gly Thr Thr Ala Asp Gly Ala Thr Gly 
                245                 250                 255     


Lys Glu Lys Ala Ser Thr Tyr Val Lys Gly Val Ala Pro Glu Ala Gln 
            260                 265                 270         


Ile Leu Ala Met Gln Val Ile Asp Glu Phe Pro Asp Glu Asn Ala Asn 
        275                 280                 285             


Asp Ile Ser Arg Ala Ile Arg Asp Ala Val Ala Leu Gly Ala Asn Ala 
    290                 295                 300                 


Ile Gln Met Ser Leu Gly Ile Gly Val Thr Glu Gln Asp Leu Thr Asp 
305                 310                 315                 320 


Glu Glu Gln Ala Ala Val Gln Tyr Ala Thr Glu His Gly Val Phe Val 
                325                 330                 335     


Ser Ile Ser Ala Gly Asn Asn Ala Ile Ala Gly Ser Ile Ile Gly Ser 
            340                 345                 350         


Lys Thr Pro Asn Asp Ile Ser Thr Ala Tyr Ala Pro Lys Asn Asp Ser 
        355                 360                 365             


Thr Ile Gly Asp Pro Gly Ala Ala Ala Ser Ala Met Thr Val Ala Ala 
    370                 375                 380                 


Glu Thr Ser Ala Thr Gly Ala Asp Ser Gln Met Asp Gly Phe Ser Ser 
385                 390                 395                 400 


Trp Gly Pro Met Ala Asp Tyr Thr Leu Lys Pro Asp Ile Ser Ala Pro 
                405                 410                 415     


Gly Asp Asn Val Thr Ser Thr Ala Ile Asp Pro Ala Thr Asn Thr Gln 
            420                 425                 430         


Thr Tyr Ala Val Glu Ser Gly Thr Ser Met Ala Gly Pro Phe Asn Ala 
        435                 440                 445             


Gly Ala Ala Leu Leu Val Met Gln Lys Ile Lys Ala Thr Gln Pro Asp 
    450                 455                 460                 


Leu Thr Gly Ala Asp Leu Val Lys Ala Val Lys Leu Ala Leu Met Asn 
465                 470                 475                 480 


Ala Ala Glu Pro Met Lys Asp Ile Asn Tyr Pro Asp Thr Tyr Ile Ser 
                485                 490                 495     


Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Ala Lys Ala Gly Asp 
            500                 505                 510         


Leu Thr Val Thr Ala Glu Gly Ser Asn Asp Ala Gly Ser Val Ser Leu 
        515                 520                 525             


Gly Lys Ile Gly Lys Thr Thr Thr Phe Thr Val Thr Leu Thr Asn His 
    530                 535                 540                 


Gly Lys Thr Ala Gln Asn Tyr Thr Val Asp Thr Asn Gly Gly Pro Leu 
545                 550                 555                 560 


Thr Gln Val Arg Asp Ala Ser Asn Gly Asn Thr Val His Asp Glu Thr 
                565                 570                 575     


Leu Val Gly Ala Thr Val Asn Thr Asp Thr Ala Asn Phe Thr Leu Ala 
            580                 585                 590         


Ala Gly Glu Thr Lys Lys Val Thr Phe Lys Leu Ser Leu Asp Asp Ser 
        595                 600                 605             


Val Ala Ala Asn Gln Leu Val Glu Gly Tyr Leu Thr Phe Lys Ala Thr 
    610                 615                 620                 


Asp Ala Ala Gln Thr Ile Ser Val Pro Tyr Leu Gly Tyr Tyr Gly Asp 
625                 630                 635                 640 


Leu Thr Asp Glu Gln Val Ile Asp Ala Pro Ala Asn Ser Gly Glu Ser 
                645                 650                 655     


Ile Phe Asn Gly Gly Tyr Leu Val Asp Asn Asn Asn Asn Pro Leu Gly 
            660                 665                 670         


Val Thr Asp Ala Ala Ser Leu Ser Asn Leu Val Asn Thr Asp Thr Thr 
        675                 680                 685             


Gly Lys Tyr Thr Trp Thr Leu Val Pro Thr Tyr Val Asp Asn Lys Lys 
    690                 695                 700                 


Val Ser Phe Ser Pro Asn Gly Asp Gly Ala Ser Asp Thr Val Phe Pro 
705                 710                 715                 720 


Tyr Val Phe Ser Lys Gln Asn Leu Lys Ser Val Thr Ile Gln Ile Leu 
                725                 730                 735     


Asp Ala Gln Gly His Val Val Arg Ile Leu Asp Lys Glu Asn Asn Thr 
            740                 745                 750         


Ser Lys Ser Tyr Leu Gln Asn Gly Asn Ser Phe Asn Ser Asp Leu Gly 
        755                 760                 765             


Leu Ser Thr Asp Met Arg Leu Asp Pro Asn Ala Phe Thr Trp Asp Gly 
    770                 775                 780                 


Lys Val Tyr Asp Gln Ala Thr Gly Lys Tyr Val Thr Ala Pro Asp Gly 
785                 790                 795                 800 


Lys Tyr Thr Tyr Arg Leu Val Thr Glu Gln Tyr Asn Thr Gly Ala Gln 
                805                 810                 815     


Gln Asn Gln Asp Tyr Asp Leu Pro Val Thr Val Asp Thr Val Ala Pro 
            820                 825                 830         


Thr Leu Thr Gly Leu Ser Tyr Gln Asp Gly Arg Val Ser Val His Tyr 
        835                 840                 845             


Asp Asp Gln Gly Ala Gly Phe Thr Lys Phe Ser Asp Leu Ala Leu Lys 
    850                 855                 860                 


Ile Gly Asn Lys Ala Tyr Gly Val Asn Leu Asn Asn Asn Gly Gln Asn 
865                 870                 875                 880 


Asn Asp Gly Thr Leu Ser Phe Glu Leu Thr Ala Ala Gln Lys Ala Ala 
                885                 890                 895     


Leu Glu Asn Ser Asp Gly Ser Leu Thr Leu Thr Leu Thr Asp Val Ala 
            900                 905                 910         


Gly Asn Lys Thr Ser Ala Ser Leu Gln Ala Thr Ala Gly Thr His Gln 
        915                 920                 925             


Thr Asp Thr Thr Thr Pro Thr Ser Asp Val Ala Pro Gln Phe Thr Trp 
    930                 935                 940                 


Lys Val Gly Asp Gly Pro His Asn Phe Trp Arg Ser Glu Gly Phe Val 
945                 950                 955                 960 


Gln Ala Val Ser Asp Gln Thr Ser Phe Thr Ala Tyr Ala Gln Val Pro 
                965                 970                 975     


Ala Gly Val Asp Trp Ile Val Tyr Ala Thr Asp Ala Gln Thr Gly Lys 
            980                 985                 990         


Val Phe Pro Gly Thr Val Asp Thr  Lys Thr Gly Thr Val  Thr Phe Asn 
        995                 1000                 1005             


Leu Thr  Glu Ser Ala Pro Tyr  Gly Asp Phe Val Gly  Thr Val Leu 
    1010                 1015                 1020             


Ser Pro  Thr Ala Asp Phe Gly  Thr Tyr Glu Glu Ala  Gly Arg Ala 
    1025                 1030                 1035             


Asp Gly  Asp Glu Met Ile Val  Phe Leu Asp Ala Asn  Gly Thr Ala 
    1040                 1045                 1050             


Gly Tyr  Gly His Phe Ser Gln  Lys Asn Val His Val  Val Val Pro 
    1055                 1060                 1065             


Leu Gln  Asp Asn Ala Lys Ala  Ala Ala Asn Ala Thr  Lys Thr Ser 
    1070                 1075                 1080             


Gly Ala  Pro Val Leu Gly Gly  Arg Ala Phe Ser Gln  Ile Thr Thr 
    1085                 1090                 1095             


His Ala  Gln Pro Thr Ala Gly  Leu Lys Phe Asp Lys  Phe Asn Asp 
    1100                 1105                 1110             


Asn Ser  Phe Thr Leu Val Gly  Ala Asp Gln Val Ala  Asp Ile Tyr 
    1115                 1120                 1125             


Asn Ala  Gln Thr Gly Gln Leu  Thr Ile Thr Gly His  Val Asp Asn 
    1130                 1135                 1140             


Pro Ala  Gly Lys Thr Leu Thr  Val Thr Asp Ala Thr  Glu Pro Ala 
    1145                 1150                 1155             


Lys Thr  Val Ala Ile Gly Ala  Asp Gly Lys Phe Ser  Phe Thr Val 
    1160                 1165                 1170             


Pro Phe  Lys Ala Ala Glu Gln  Gln Ser Val Gly Tyr  Arg Leu Thr 
    1175                 1180                 1185             


Glu Pro  Ala Thr Asp Gly Ser  Lys Ser Thr Lys Thr  Ala Tyr Gly 
    1190                 1195                 1200             


Glu Leu  Gln Ile Tyr Leu Asp  Thr Ile Phe Pro Thr  Leu Asp Leu 
    1205                 1210                 1215             


Pro Gln  Ala Asp Thr Leu Lys  Val Asp Asp Gln Gly  Asn Tyr Asp 
    1220                 1225                 1230             


Ile Thr  Thr Thr Ser Asp Thr  Phe Thr Val Ser Gly  Thr Val Asn 
    1235                 1240                 1245             


Asp Asn  Ile Asn Gly Tyr Arg  Leu Tyr Thr Asn Gly  Asp Asn Val 
    1250                 1255                 1260             


Val His  Gln Lys Asn Leu Ala  Gly Phe Asn Asn His  Leu Asp Pro 
    1265                 1270                 1275             


Gln Ser  Thr Thr Ser Asn Pro  Tyr Gly Ala Ala Asp  Phe Asn Gln 
    1280                 1285                 1290             


Thr Tyr  Thr Leu Lys Asp Gly  Asp Asn Tyr Phe Thr  Val Thr Ala 
    1295                 1300                 1305             


Val Asp  Met Val Gly Asn Lys  Val Thr Lys Val Phe  His Val Val 
    1310                 1315                 1320             


Lys Val  Lys Thr Pro Thr Pro  Thr Pro Gly Asp Asn  Gly Asn Thr 
    1325                 1330                 1335             


Ser Gly  Thr Asp Asn Ser Gly  Asn Gly Asn Pro Asn  Gln Gln Gly 
    1340                 1345                 1350             


Thr Gly  Gly Asn Ala Gly Asn  Gln Gly Gly Asn Ala  Gly Asn Gln 
    1355                 1360                 1365             


Gly Asn  Asn Gly Gly Thr Gln  Gly Gly Asn Gly Ser  Gly Gln Thr 
    1370                 1375                 1380             


Pro Ala  Thr Gly Asn Gly Thr  Pro Thr Thr Pro Thr  Thr Gly Thr 
    1385                 1390                 1395             


Gly Thr  Asn Gly Gly Asn Gly  Asn Asn Arg Gln Gln  Ser Pro Glu 
    1400                 1405                 1410             


Leu Val  Thr Leu Asp Asn Lys  Leu Lys Asp Gln Thr  Lys Thr Pro 
    1415                 1420                 1425             


Ala Ala  Lys Asn Gly Thr Thr  Ala Asn Gly Thr Lys  Gln Ala Ala 
    1430                 1435                 1440             


Thr Gly  Lys Thr Met Pro Gln  Ala Gly Glu Ser Gln  Ser Pro Leu 
    1445                 1450                 1455             


Ala Val  Ile Gly Leu Ala Ile  Val Ser Ile Phe Ser  Phe Met Gly 
    1460                 1465                 1470             


Phe Ala  Ser Arg Lys Lys Arg  Val 
    1475                 1480     


<210>  47
<211>  1658
<212>  PRT
<213>  Enterococcus sp. HMSC069A01

<400>  47

Met Arg Arg Asn Ser Met Thr Glu Met Lys Arg His Tyr Lys Leu Tyr 
1               5                   10                  15      


Lys Ser Gly Ser Lys Gly Val Ala Ala Ala Ile Ile Thr Val Ser Ala 
            20                  25                  30          


Gly Ala Ile Val Leu Ser Gly Tyr Ala Thr Gln Ser Val Ser Ala Asp 
        35                  40                  45              


Thr Thr Ala Ala Ala Thr Val Gln Thr Gln Thr Asp Thr Glu Thr Thr 
    50                  55                  60                  


Gly Gln Ser Ser Thr Ala Val Asp Asp Ala Gln Asn Ala Ala Asp Asn 
65                  70                  75                  80  


His Thr Gln Ser Ser Thr Ala Thr Glu Glu Gly Thr Thr Pro Ala Thr 
                85                  90                  95      


Thr Thr Ser Gln Ser Gln Ala Gly Ser Ser Ala Thr Thr Ser Gly Ala 
            100                 105                 110         


Thr Ala Thr Thr Ala Thr Ser Gly Ala Ser Ala Ser Ser Ser Ser Ala 
        115                 120                 125             


Ala Thr Thr Leu Ala Ala Thr Val Gln Thr Gln Thr Asp Thr Glu Thr 
    130                 135                 140                 


Thr Gly Gln Ser Ser Thr Ala Val Asp Asp Ala Gln Asn Ala Ala Asp 
145                 150                 155                 160 


Asn His Thr Gln Ser Ser Thr Ala Thr Glu Glu Gly Thr Thr Pro Ala 
                165                 170                 175     


Thr Thr Thr Ser Gln Ser Gln Ala Gly Ser Ser Ala Ala Thr Ser Gly 
            180                 185                 190         


Ala Thr Ala Thr Ser Gly Ala Ser Ala Ser Ser Ser Ser Ala Ala Thr 
        195                 200                 205             


Thr Leu Ala Ala Thr Val Gln Thr Gln Thr Asp Thr Glu Thr Thr Gly 
    210                 215                 220                 


Gln Ser Ser Thr Ala Val Asp Asp Ala Gln Asn Ala Ala Asp Asn His 
225                 230                 235                 240 


Thr Gln Ser Ser Thr Ala Thr Glu Glu Gly Thr Thr Pro Ala Gln Ser 
                245                 250                 255     


Ser Ala Thr Ala Ser Gln Ala Thr Pro Ala Thr Thr Thr Ser Gln Ser 
            260                 265                 270         


Gln Ala Gly Ser Ser Ala Ala Thr Ser Gly Ala Thr Ala Thr Ser Gly 
        275                 280                 285             


Ala Ser Ala Ser Ser Ser Ser Ala Ala Thr Thr Thr Thr Pro Ala Ala 
    290                 295                 300                 


Thr Thr Thr Ala Gln Ala Thr Ala Asp Ala Thr Ala Asp Pro Gly Pro 
305                 310                 315                 320 


Ala Asn Gln Asp Thr Leu Thr Lys Gly Asn Val Glu Gly Leu Trp Asn 
                325                 330                 335     


Glu Gly Tyr Gln Gly Gln Gly Met Val Val Ala Val Ile Asp Ser Gly 
            340                 345                 350         


Val Gln Pro His Ala Asp Leu Arg Leu Thr Asp Asp Ser Thr Ala Ala 
        355                 360                 365             


Ile Ser Lys Asp Ala Ala Glu Ala Ala Ile Ala Lys Leu Gly Tyr Gly 
    370                 375                 380                 


Thr Tyr Val Asn Ser Lys Ile Pro Phe Ala Tyr Asp Tyr Val Asn Asn 
385                 390                 395                 400 


Asp Ser Val Asn Thr Gly Thr Thr Val Ser Gly Ser Thr His Gly Glu 
                405                 410                 415     


His Val Ala Gly Ile Ile Ala Ala Asn Gly Thr Val Ala Asp Gly Ala 
            420                 425                 430         


Thr Gly Thr Ser Lys Ala Ser Val Tyr Val Lys Gly Val Ala Pro Glu 
        435                 440                 445             


Ala Gln Ile Leu Ala Met Gln Val Ile Asp Glu Phe Pro Asp Glu Asn 
    450                 455                 460                 


Ala Asn Asp Ile Ser Arg Ala Ile Arg Asp Ala Val Ser Met Gly Ala 
465                 470                 475                 480 


Asn Ala Ile Gln Met Ser Leu Gly Val Gly Val Ala Glu Gln Asp Leu 
                485                 490                 495     


Thr Asp Glu Glu Gln Ala Ala Val Gln Tyr Ala Thr Asp His Gly Val 
            500                 505                 510         


Phe Val Ser Ile Ser Ala Ser Asn Asn Gly Asn Ala Ala Ser Ile Val 
        515                 520                 525             


Gly Ser Asp Lys Lys Asn Asp Ile Ser Thr Ala Tyr Val Pro Lys Asn 
    530                 535                 540                 


Asp Ser Thr Ile Ala Asp Pro Gly Ala Ala Ala Ser Ala Met Thr Val 
545                 550                 555                 560 


Ala Ala Glu Lys Ser Ala Thr Gly Ala Asp Ser Glu Met Asp Gly Phe 
                565                 570                 575     


Ser Ser Trp Gly Pro Met Ala Asp Tyr Thr Leu Lys Pro Asp Ile Ala 
            580                 585                 590         


Ala Pro Gly Asp Arg Val Thr Ser Thr Ala Ile Asp Pro Lys Thr Asn 
        595                 600                 605             


Thr Gln Thr Tyr Ala Val Glu Ser Gly Thr Ser Met Ala Gly Pro Tyr 
    610                 615                 620                 


Asp Ala Gly Ala Ala Leu Leu Val Met Gln Lys Leu Lys Ala Thr Arg 
625                 630                 635                 640 


Pro Glu Leu Gln Gly Ala Asp Leu Val Lys Ala Val Lys Leu Ala Leu 
                645                 650                 655     


Met Asn Ala Ala Asp Pro Met Ile Asp Leu Asn Tyr Pro Asp Thr Tyr 
            660                 665                 670         


Val Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Thr Lys Ala 
        675                 680                 685             


Gly Asn Leu Asp Val Ala Ala Glu Gly Thr Asn Asn Ala Gly Ser Val 
    690                 695                 700                 


Ser Leu Gly Lys Ile Gly Arg Thr Thr Ser Phe Asn Val Thr Leu Thr 
705                 710                 715                 720 


Asn Tyr Gly Gln Thr Thr Gln Ser Tyr Thr Val Asp Tyr Asp Gly Gly 
                725                 730                 735     


Pro Leu Thr Gln Val Arg Asp Thr Ser Lys Gly Asn Ile Val His Asp 
            740                 745                 750         


Gln Lys Leu Ala Gly Ala Ala Val Asn Ser Ala Thr Pro Thr Phe Thr 
        755                 760                 765             


Leu Ala Pro Gly Ala Ser Lys Val Val Thr Phe Thr Leu Thr Leu Asp 
    770                 775                 780                 


Asp Ala Val Ala Ala Asn Gln Ile Val Glu Gly Tyr Leu Thr Phe Lys 
785                 790                 795                 800 


Ala Gly Asp Asp Thr Gln Thr Ile Ser Val Pro Tyr Leu Gly Tyr Phe 
                805                 810                 815     


Gly Asp Leu Thr Thr Glu Gln Ile Ile Asp Asp Pro Ala Asn Lys Gln 
            820                 825                 830         


Asp Ser Ile Phe Lys Gly Gly Tyr Leu Val Asp Asn Asn Asn Asn Pro 
        835                 840                 845             


Leu Gly Val Thr Asp Ala Ala Ser Leu Ser Asn Leu Val Asn Ser Asp 
    850                 855                 860                 


Val Thr Gly Lys Tyr Thr Trp Gly Gln Val Pro Ala Tyr Ile Glu Asn 
865                 870                 875                 880 


Gly Lys Val Ser Phe Ser Pro Asn Gly Asp Gly Ala Ser Asp Thr Val 
                885                 890                 895     


Tyr Pro Tyr Val Phe Ala Lys Gln Asn Leu Lys Ala Val Thr Ile Gln 
            900                 905                 910         


Ile Leu Asp Ala Asn Gly Asn Leu Val Arg Val Leu Asp Lys Glu Asn 
        915                 920                 925             


Asn Thr Thr Lys Ser Tyr Leu Gln Asn Gly Phe Ser His Asn Ser Asp 
    930                 935                 940                 


Leu Gly Leu Ser Thr Asp Met Arg Leu Asp Ala Asp Ala Phe Thr Trp 
945                 950                 955                 960 


Asp Gly Arg Ile Tyr Asp Gln Gln Thr Gly Lys Tyr Ile Thr Ala Pro 
                965                 970                 975     


Asp Gly Arg Tyr Thr Tyr Arg Ile Val Thr Glu Gln Tyr Asn Asp Gly 
            980                 985                 990         


Ala Glu Gln Glu Gln Asn Phe Asp  Leu Pro Val Ala Val  Asp Thr Val 
        995                 1000                 1005             


Ala Pro  Thr Leu Thr Gly Leu  Thr Tyr Ala Glu Gly  Gln Leu Thr 
    1010                 1015                 1020             


Ala Ser  Tyr Asn Asp Gln Gly  Ala Gly Phe Ser Gln  Phe Ser Asp 
    1025                 1030                 1035             


Ala Val  Leu Lys Ile Gly Ala  Gln Glu Tyr Gly Val  Ser Leu Asp 
    1040                 1045                 1050             


Asn Asn  Gly Gln Ser Asn Ala  Gly Thr Ile Ser Phe  Lys Leu Thr 
    1055                 1060                 1065             


Ala Ala  Gln Met Ala Ala Leu  Ala Thr Ser Asp Gly  Gln Leu Thr 
    1070                 1075                 1080             


Leu Thr  Val Thr Asp Val Ala  Gly Asn His Thr Ser  Ala Ser Val 
    1085                 1090                 1095             


Gln Ala  Phe Ala Gly Thr Thr  Ser Ala Ser Ala Thr  Asp Thr Ala 
    1100                 1105                 1110             


Ala Asn  Val Ala Pro Gln Phe  Ser Trp Gln Val Gly  Asp Gly Ser 
    1115                 1120                 1125             


Asn Asn  Tyr Trp Arg Thr Asn  Gly Phe Val Gln Ala  Val Ser Asp 
    1130                 1135                 1140             


Gln Thr  Ser Phe Thr Thr Tyr  Ala Gln Val Pro Ala  Gly Val Asp 
    1145                 1150                 1155             


Trp Ile  Val Tyr Ala Thr Asp  Ala Arg Ala Gly Lys  Val Phe Pro 
    1160                 1165                 1170             


Gly Lys  Val Asp Thr Ala Thr  Gly Ile Val Thr Phe  Asn Leu Thr 
    1175                 1180                 1185             


Glu Gly  Ala Pro Tyr Gly Asp  Phe Val Gly Thr Val  Leu Tyr Pro 
    1190                 1195                 1200             


Thr Ala  Asn Phe Gly Glu Tyr  Lys Arg Ala Gly Arg  Ala Asp Gly 
    1205                 1210                 1215             


Asp Glu  Met Ile Val Phe Leu  Asp Ala Asp Gly Thr  Ala Gly Tyr 
    1220                 1225                 1230             


Gly His  Phe Ser Thr Thr Asn  Pro His Thr Val Ile  Ala Leu Arg 
    1235                 1240                 1245             


Asp Asn  Ala Asp Ala Ala Ala  Asp Ala Thr Val Thr  Thr Gly Ala 
    1250                 1255                 1260             


Pro Val  Leu Ser Gly Arg Ala  Phe Ala Asp Ile Thr  Thr His Ala 
    1265                 1270                 1275             


Gln Pro  Thr Ala Gly Leu Ser  Phe Asp Lys Phe Asn  Asp Asn Thr 
    1280                 1285                 1290             


Phe Thr  Leu Val Gly Ala Asp  Gln Val Ala Asp Val  Tyr Asp Pro 
    1295                 1300                 1305             


Gln Thr  Gly Glu Leu Thr Ile  Thr Gly Lys Val Ala  Asp Pro Ala 
    1310                 1315                 1320             


Gly Lys  Ala Met Thr Val Thr  Asp Ala Thr Glu Pro  Thr Lys Ala 
    1325                 1330                 1335             


Val Ala  Ile Asn Ala Asp Gly  Thr Phe Ser Phe Thr  Val Pro Phe 
    1340                 1345                 1350             


Lys Ala  Ala Glu Gln Gln Ser  Val Gly Tyr Arg Leu  Thr Thr Thr 
    1355                 1360                 1365             


Thr Thr  Asn Asp Asp Gly Thr  Thr Ala Ser Ser Thr  Ala Tyr Gly 
    1370                 1375                 1380             


Ala Leu  Gln Ile Tyr Leu Asp  Thr Val Phe Pro Thr  Leu Ser Met 
    1385                 1390                 1395             


Pro Gln  Ala Asp Thr Leu Thr  Val Asp Ala Asp Gly  Asn Tyr Asp 
    1400                 1405                 1410             


Ile Thr  Thr Ser Asp Pro Thr  Phe Thr Val Thr Gly  Thr Val Asn 
    1415                 1420                 1425             


Asp Asn  Val Asn Gly Tyr Arg  Leu Tyr Thr Asn Gly  Asp Asn Val 
    1430                 1435                 1440             


Val His  Gln Lys Asn Leu Ala  Gly Phe Asn Asn His  Val Asp Ala 
    1445                 1450                 1455             


Asp Ala  Ala Ser Ser Asn Pro  Tyr Gly Ala Ala Asp  Phe Ser Gln 
    1460                 1465                 1470             


Thr Tyr  Asn Leu Leu Glu Gly  Asp Asn Tyr Phe Thr  Val Thr Ala 
    1475                 1480                 1485             


Val Asp  Met Val Gly Asn Thr  Ile Thr Lys Val Phe  His Val Val 
    1490                 1495                 1500             


Arg Val  Asp Ala Thr Ser Val  Thr Pro Lys Ser Gln  Gly Ser Lys 
    1505                 1510                 1515             


Gly Thr  Ala Ile Thr Ser Pro  Val Val Asp Gly Gly  Gln Arg Gly 
    1520                 1525                 1530             


Gln Ala  Gln Gly Ala Pro Asp  Val His Pro Ala Ala  Pro Gly Tyr 
    1535                 1540                 1545             


Lys Asn  Asp Gly Gln Gly Gly  Val Gln Leu Val Pro  Ala Ala Ile 
    1550                 1555                 1560             


Thr Ser  Pro Gly Val Asp Gly  Gly Gln Arg Gly Gln  Ala Gln Gly 
    1565                 1570                 1575             


Ala Pro  Asp Val His Pro Ala  Ala Pro Gly Tyr Lys  Asn Asp Gly 
    1580                 1585                 1590             


Gln Gly  Gly Val Gln Leu Val  Pro Ala Ala Ser Gln  Ala Gly Arg 
    1595                 1600                 1605             


Ser Gly  Thr Glu Gln Gly Gln  Ser Pro Ala Thr Thr  Thr Ala Ala 
    1610                 1615                 1620             


Ala Leu  Pro Ala Thr Gly Glu  Thr His Ser Pro Leu  Ala Ala Ile 
    1625                 1630                 1635             


Gly Leu  Ala Ile Leu Ser Val  Leu Gly Leu Ala Gly  Leu Ala Ser 
    1640                 1645                 1650             


Arg Lys  Arg Arg Val 
    1655             


<210>  48
<211>  1603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Enterococcus sp. HMSC069A01 protease

<400>  48

Gln Thr Gln Thr Asp Thr Glu Thr Thr Gly Gln Ser Ser Thr Ala Val 
1               5                   10                  15      


Asp Asp Ala Gln Asn Ala Ala Asp Asn His Thr Gln Ser Ser Thr Ala 
            20                  25                  30          


Thr Glu Glu Gly Thr Thr Pro Ala Thr Thr Thr Ser Gln Ser Gln Ala 
        35                  40                  45              


Gly Ser Ser Ala Thr Thr Ser Gly Ala Thr Ala Thr Thr Ala Thr Ser 
    50                  55                  60                  


Gly Ala Ser Ala Ser Ser Ser Ser Ala Ala Thr Thr Leu Ala Ala Thr 
65                  70                  75                  80  


Val Gln Thr Gln Thr Asp Thr Glu Thr Thr Gly Gln Ser Ser Thr Ala 
                85                  90                  95      


Val Asp Asp Ala Gln Asn Ala Ala Asp Asn His Thr Gln Ser Ser Thr 
            100                 105                 110         


Ala Thr Glu Glu Gly Thr Thr Pro Ala Thr Thr Thr Ser Gln Ser Gln 
        115                 120                 125             


Ala Gly Ser Ser Ala Ala Thr Ser Gly Ala Thr Ala Thr Ser Gly Ala 
    130                 135                 140                 


Ser Ala Ser Ser Ser Ser Ala Ala Thr Thr Leu Ala Ala Thr Val Gln 
145                 150                 155                 160 


Thr Gln Thr Asp Thr Glu Thr Thr Gly Gln Ser Ser Thr Ala Val Asp 
                165                 170                 175     


Asp Ala Gln Asn Ala Ala Asp Asn His Thr Gln Ser Ser Thr Ala Thr 
            180                 185                 190         


Glu Glu Gly Thr Thr Pro Ala Gln Ser Ser Ala Thr Ala Ser Gln Ala 
        195                 200                 205             


Thr Pro Ala Thr Thr Thr Ser Gln Ser Gln Ala Gly Ser Ser Ala Ala 
    210                 215                 220                 


Thr Ser Gly Ala Thr Ala Thr Ser Gly Ala Ser Ala Ser Ser Ser Ser 
225                 230                 235                 240 


Ala Ala Thr Thr Thr Thr Pro Ala Ala Thr Thr Thr Ala Gln Ala Thr 
                245                 250                 255     


Ala Asp Ala Thr Ala Asp Pro Gly Pro Ala Asn Gln Asp Thr Leu Thr 
            260                 265                 270         


Lys Gly Asn Val Glu Gly Leu Trp Asn Glu Gly Tyr Gln Gly Gln Gly 
        275                 280                 285             


Met Val Val Ala Val Ile Asp Ser Gly Val Gln Pro His Ala Asp Leu 
    290                 295                 300                 


Arg Leu Thr Asp Asp Ser Thr Ala Ala Ile Ser Lys Asp Ala Ala Glu 
305                 310                 315                 320 


Ala Ala Ile Ala Lys Leu Gly Tyr Gly Thr Tyr Val Asn Ser Lys Ile 
                325                 330                 335     


Pro Phe Ala Tyr Asp Tyr Val Asn Asn Asp Ser Val Asn Thr Gly Thr 
            340                 345                 350         


Thr Val Ser Gly Ser Thr His Gly Glu His Val Ala Gly Ile Ile Ala 
        355                 360                 365             


Ala Asn Gly Thr Val Ala Asp Gly Ala Thr Gly Thr Ser Lys Ala Ser 
    370                 375                 380                 


Val Tyr Val Lys Gly Val Ala Pro Glu Ala Gln Ile Leu Ala Met Gln 
385                 390                 395                 400 


Val Ile Asp Glu Phe Pro Asp Glu Asn Ala Asn Asp Ile Ser Arg Ala 
                405                 410                 415     


Ile Arg Asp Ala Val Ser Met Gly Ala Asn Ala Ile Gln Met Ser Leu 
            420                 425                 430         


Gly Val Gly Val Ala Glu Gln Asp Leu Thr Asp Glu Glu Gln Ala Ala 
        435                 440                 445             


Val Gln Tyr Ala Thr Asp His Gly Val Phe Val Ser Ile Ser Ala Ser 
    450                 455                 460                 


Asn Asn Gly Asn Ala Ala Ser Ile Val Gly Ser Asp Lys Lys Asn Asp 
465                 470                 475                 480 


Ile Ser Thr Ala Tyr Val Pro Lys Asn Asp Ser Thr Ile Ala Asp Pro 
                485                 490                 495     


Gly Ala Ala Ala Ser Ala Met Thr Val Ala Ala Glu Lys Ser Ala Thr 
            500                 505                 510         


Gly Ala Asp Ser Glu Met Asp Gly Phe Ser Ser Trp Gly Pro Met Ala 
        515                 520                 525             


Asp Tyr Thr Leu Lys Pro Asp Ile Ala Ala Pro Gly Asp Arg Val Thr 
    530                 535                 540                 


Ser Thr Ala Ile Asp Pro Lys Thr Asn Thr Gln Thr Tyr Ala Val Glu 
545                 550                 555                 560 


Ser Gly Thr Ser Met Ala Gly Pro Tyr Asp Ala Gly Ala Ala Leu Leu 
                565                 570                 575     


Val Met Gln Lys Leu Lys Ala Thr Arg Pro Glu Leu Gln Gly Ala Asp 
            580                 585                 590         


Leu Val Lys Ala Val Lys Leu Ala Leu Met Asn Ala Ala Asp Pro Met 
        595                 600                 605             


Ile Asp Leu Asn Tyr Pro Asp Thr Tyr Val Ser Pro Arg Arg Gln Gly 
    610                 615                 620                 


Ala Gly Gln Ile Asp Val Thr Lys Ala Gly Asn Leu Asp Val Ala Ala 
625                 630                 635                 640 


Glu Gly Thr Asn Asn Ala Gly Ser Val Ser Leu Gly Lys Ile Gly Arg 
                645                 650                 655     


Thr Thr Ser Phe Asn Val Thr Leu Thr Asn Tyr Gly Gln Thr Thr Gln 
            660                 665                 670         


Ser Tyr Thr Val Asp Tyr Asp Gly Gly Pro Leu Thr Gln Val Arg Asp 
        675                 680                 685             


Thr Ser Lys Gly Asn Ile Val His Asp Gln Lys Leu Ala Gly Ala Ala 
    690                 695                 700                 


Val Asn Ser Ala Thr Pro Thr Phe Thr Leu Ala Pro Gly Ala Ser Lys 
705                 710                 715                 720 


Val Val Thr Phe Thr Leu Thr Leu Asp Asp Ala Val Ala Ala Asn Gln 
                725                 730                 735     


Ile Val Glu Gly Tyr Leu Thr Phe Lys Ala Gly Asp Asp Thr Gln Thr 
            740                 745                 750         


Ile Ser Val Pro Tyr Leu Gly Tyr Phe Gly Asp Leu Thr Thr Glu Gln 
        755                 760                 765             


Ile Ile Asp Asp Pro Ala Asn Lys Gln Asp Ser Ile Phe Lys Gly Gly 
    770                 775                 780                 


Tyr Leu Val Asp Asn Asn Asn Asn Pro Leu Gly Val Thr Asp Ala Ala 
785                 790                 795                 800 


Ser Leu Ser Asn Leu Val Asn Ser Asp Val Thr Gly Lys Tyr Thr Trp 
                805                 810                 815     


Gly Gln Val Pro Ala Tyr Ile Glu Asn Gly Lys Val Ser Phe Ser Pro 
            820                 825                 830         


Asn Gly Asp Gly Ala Ser Asp Thr Val Tyr Pro Tyr Val Phe Ala Lys 
        835                 840                 845             


Gln Asn Leu Lys Ala Val Thr Ile Gln Ile Leu Asp Ala Asn Gly Asn 
    850                 855                 860                 


Leu Val Arg Val Leu Asp Lys Glu Asn Asn Thr Thr Lys Ser Tyr Leu 
865                 870                 875                 880 


Gln Asn Gly Phe Ser His Asn Ser Asp Leu Gly Leu Ser Thr Asp Met 
                885                 890                 895     


Arg Leu Asp Ala Asp Ala Phe Thr Trp Asp Gly Arg Ile Tyr Asp Gln 
            900                 905                 910         


Gln Thr Gly Lys Tyr Ile Thr Ala Pro Asp Gly Arg Tyr Thr Tyr Arg 
        915                 920                 925             


Ile Val Thr Glu Gln Tyr Asn Asp Gly Ala Glu Gln Glu Gln Asn Phe 
    930                 935                 940                 


Asp Leu Pro Val Ala Val Asp Thr Val Ala Pro Thr Leu Thr Gly Leu 
945                 950                 955                 960 


Thr Tyr Ala Glu Gly Gln Leu Thr Ala Ser Tyr Asn Asp Gln Gly Ala 
                965                 970                 975     


Gly Phe Ser Gln Phe Ser Asp Ala Val Leu Lys Ile Gly Ala Gln Glu 
            980                 985                 990         


Tyr Gly Val Ser Leu Asp Asn Asn  Gly Gln Ser Asn Ala  Gly Thr Ile 
        995                 1000                 1005             


Ser Phe  Lys Leu Thr Ala Ala  Gln Met Ala Ala Leu  Ala Thr Ser 
    1010                 1015                 1020             


Asp Gly  Gln Leu Thr Leu Thr  Val Thr Asp Val Ala  Gly Asn His 
    1025                 1030                 1035             


Thr Ser  Ala Ser Val Gln Ala  Phe Ala Gly Thr Thr  Ser Ala Ser 
    1040                 1045                 1050             


Ala Thr  Asp Thr Ala Ala Asn  Val Ala Pro Gln Phe  Ser Trp Gln 
    1055                 1060                 1065             


Val Gly  Asp Gly Ser Asn Asn  Tyr Trp Arg Thr Asn  Gly Phe Val 
    1070                 1075                 1080             


Gln Ala  Val Ser Asp Gln Thr  Ser Phe Thr Thr Tyr  Ala Gln Val 
    1085                 1090                 1095             


Pro Ala  Gly Val Asp Trp Ile  Val Tyr Ala Thr Asp  Ala Arg Ala 
    1100                 1105                 1110             


Gly Lys  Val Phe Pro Gly Lys  Val Asp Thr Ala Thr  Gly Ile Val 
    1115                 1120                 1125             


Thr Phe  Asn Leu Thr Glu Gly  Ala Pro Tyr Gly Asp  Phe Val Gly 
    1130                 1135                 1140             


Thr Val  Leu Tyr Pro Thr Ala  Asn Phe Gly Glu Tyr  Lys Arg Ala 
    1145                 1150                 1155             


Gly Arg  Ala Asp Gly Asp Glu  Met Ile Val Phe Leu  Asp Ala Asp 
    1160                 1165                 1170             


Gly Thr  Ala Gly Tyr Gly His  Phe Ser Thr Thr Asn  Pro His Thr 
    1175                 1180                 1185             


Val Ile  Ala Leu Arg Asp Asn  Ala Asp Ala Ala Ala  Asp Ala Thr 
    1190                 1195                 1200             


Val Thr  Thr Gly Ala Pro Val  Leu Ser Gly Arg Ala  Phe Ala Asp 
    1205                 1210                 1215             


Ile Thr  Thr His Ala Gln Pro  Thr Ala Gly Leu Ser  Phe Asp Lys 
    1220                 1225                 1230             


Phe Asn  Asp Asn Thr Phe Thr  Leu Val Gly Ala Asp  Gln Val Ala 
    1235                 1240                 1245             


Asp Val  Tyr Asp Pro Gln Thr  Gly Glu Leu Thr Ile  Thr Gly Lys 
    1250                 1255                 1260             


Val Ala  Asp Pro Ala Gly Lys  Ala Met Thr Val Thr  Asp Ala Thr 
    1265                 1270                 1275             


Glu Pro  Thr Lys Ala Val Ala  Ile Asn Ala Asp Gly  Thr Phe Ser 
    1280                 1285                 1290             


Phe Thr  Val Pro Phe Lys Ala  Ala Glu Gln Gln Ser  Val Gly Tyr 
    1295                 1300                 1305             


Arg Leu  Thr Thr Thr Thr Thr  Asn Asp Asp Gly Thr  Thr Ala Ser 
    1310                 1315                 1320             


Ser Thr  Ala Tyr Gly Ala Leu  Gln Ile Tyr Leu Asp  Thr Val Phe 
    1325                 1330                 1335             


Pro Thr  Leu Ser Met Pro Gln  Ala Asp Thr Leu Thr  Val Asp Ala 
    1340                 1345                 1350             


Asp Gly  Asn Tyr Asp Ile Thr  Thr Ser Asp Pro Thr  Phe Thr Val 
    1355                 1360                 1365             


Thr Gly  Thr Val Asn Asp Asn  Val Asn Gly Tyr Arg  Leu Tyr Thr 
    1370                 1375                 1380             


Asn Gly  Asp Asn Val Val His  Gln Lys Asn Leu Ala  Gly Phe Asn 
    1385                 1390                 1395             


Asn His  Val Asp Ala Asp Ala  Ala Ser Ser Asn Pro  Tyr Gly Ala 
    1400                 1405                 1410             


Ala Asp  Phe Ser Gln Thr Tyr  Asn Leu Leu Glu Gly  Asp Asn Tyr 
    1415                 1420                 1425             


Phe Thr  Val Thr Ala Val Asp  Met Val Gly Asn Thr  Ile Thr Lys 
    1430                 1435                 1440             


Val Phe  His Val Val Arg Val  Asp Ala Thr Ser Val  Thr Pro Lys 
    1445                 1450                 1455             


Ser Gln  Gly Ser Lys Gly Thr  Ala Ile Thr Ser Pro  Val Val Asp 
    1460                 1465                 1470             


Gly Gly  Gln Arg Gly Gln Ala  Gln Gly Ala Pro Asp  Val His Pro 
    1475                 1480                 1485             


Ala Ala  Pro Gly Tyr Lys Asn  Asp Gly Gln Gly Gly  Val Gln Leu 
    1490                 1495                 1500             


Val Pro  Ala Ala Ile Thr Ser  Pro Gly Val Asp Gly  Gly Gln Arg 
    1505                 1510                 1515             


Gly Gln  Ala Gln Gly Ala Pro  Asp Val His Pro Ala  Ala Pro Gly 
    1520                 1525                 1530             


Tyr Lys  Asn Asp Gly Gln Gly  Gly Val Gln Leu Val  Pro Ala Ala 
    1535                 1540                 1545             


Ser Gln  Ala Gly Arg Ser Gly  Thr Glu Gln Gly Gln  Ser Pro Ala 
    1550                 1555                 1560             


Thr Thr  Thr Ala Ala Ala Leu  Pro Ala Thr Gly Glu  Thr His Ser 
    1565                 1570                 1575             


Pro Leu  Ala Ala Ile Gly Leu  Ala Ile Leu Ser Val  Leu Gly Leu 
    1580                 1585                 1590             


Ala Gly  Leu Ala Ser Arg Lys  Arg Arg Val 
    1595                 1600             


<210>  49
<211>  1519
<212>  PRT
<213>  Actinomyces sp. oral taxon 180 str. F0310

<400>  49

Met Lys Arg Ser Arg Leu Ala Val Leu Ser Leu Ala Ala Thr Leu Gly 
1               5                   10                  15      


Ile Ala Ile Ile Ala Pro Gln Ala Phe Ala Asp Ser Ala Asp Thr Leu 
            20                  25                  30          


Val Ser Ala Pro Ala Ser Pro Pro Ser Ser Asn Ala Gly Lys Leu Leu 
        35                  40                  45              


Glu Pro Glu Leu Thr Ser Lys Ser Gln Tyr Asp Ala Gly Gly Ala Thr 
    50                  55                  60                  


Thr Pro Ser Gly Asp Leu Leu Pro Asp Glu Glu Ser Asn His Pro Val 
65                  70                  75                  80  


Thr Val Ile Val Glu Leu Glu Glu Gly Asp Ala Gly Val Ala Trp Tyr 
                85                  90                  95      


Arg Arg Ala Val Ser Ala Asp Ala Lys Arg Thr Val Val Lys Glu Arg 
            100                 105                 110         


Ile Arg Thr Ala Val Glu Ala Ala Ala Pro Gly Gln Val Thr Ser Gly 
        115                 120                 125             


Gly Gly Pro Val Thr Glu Val Glu Asp Tyr Glu His Val Met Glu Gly 
    130                 135                 140                 


Phe Ala Ile Glu Val Pro Ala Gly Ala Val Glu Ala Val Arg Gly Val 
145                 150                 155                 160 


Glu Gly Val Lys Arg Ala Phe Val Glu Gln Thr Val Thr Pro Ser Ser 
                165                 170                 175     


Glu Glu Gly Tyr Ser Gly Pro Gln Asn Gln Tyr Ser Leu Asp Met Thr 
            180                 185                 190         


Gly Val Asp Arg Ile Ser Gln Lys Gly Asp Gly Thr Thr Ile Ala Ile 
        195                 200                 205             


Ile Asp Thr Gly Phe Asp Thr Thr His Glu Ala Phe Ser Gly Ala Leu 
    210                 215                 220                 


Asp Glu Ser Arg Ala Ala Tyr Ser Tyr Asp Ser Ile Ser Ser Val Lys 
225                 230                 235                 240 


Arg Gly Leu Ser Thr Gly Trp Ala Gly Ala Tyr Val Ser Ala Lys Ile 
                245                 250                 255     


Pro Phe Ala Tyr Asp Tyr Gly Asp Gly Asp Ser Asp Val Ile Pro His 
            260                 265                 270         


Thr Val His Asn Met Ala His Gly Thr His Val Ala Gly Ile Ala Ala 
        275                 280                 285             


Ala Asn Gly Gly Ala Ile Leu Gly Ser Ala Pro Gly Ala Gln Leu Leu 
    290                 295                 300                 


Leu Met Lys Ala Gly Ile Asp Ala Thr Gly Gly Leu Ser Asp Ser Ala 
305                 310                 315                 320 


Ile Phe Ala Ala Leu Asp Asp Cys Ala Val Leu Lys Pro Asp Val Ile 
                325                 330                 335     


Asn Met Ser Phe Gly Tyr Ala Gly Gly Ala Ser Glu Ala Arg Asn Asp 
            340                 345                 350         


Thr Tyr Gly Ser Val Tyr Tyr Arg Leu Ser Glu Gln Gly Ile Met Leu 
        355                 360                 365             


Asn Val Ala Gly Gly Asn Phe Gly Ala Ser Ser Gln Gly Asn Ala Ser 
    370                 375                 380                 


Gly Trp Gly Leu Pro Tyr Ala Ser Asp Pro Asp Ser Ser Thr Val Ala 
385                 390                 395                 400 


Gln Pro Ser Thr Tyr Thr Ala Ser Leu Ser Val Ala Ser Val Asp Asn 
                405                 410                 415     


Ala Asn Gly Trp Gly Pro Ser Thr Tyr Lys Ala Ser Ser Phe Ser Ser 
            420                 425                 430         


Trp Gly Val Ala Pro Asn Leu Thr Leu Lys Pro Glu Ile Ala Ala Pro 
        435                 440                 445             


Gly Gly Tyr Ile Trp Ser Ala Leu Pro Gly Gly Thr Tyr Gly Tyr Ser 
    450                 455                 460                 


Ser Gly Thr Ser Met Ala Thr Pro Tyr Leu Ala Gly Met Ala Ala Asp 
465                 470                 475                 480 


Ile Lys Gln Arg Val Glu Ser Asp Pro Gly Phe Ala Tyr Met Thr Glu 
                485                 490                 495     


Ala Gln Lys Thr Gly Val Val Tyr Asn Leu Leu Met Gly Thr Ala Lys 
            500                 505                 510         


Pro Leu Val Asp Asn Glu Gly Gly Arg Gly Ala Tyr Tyr Ser Pro Arg 
        515                 520                 525             


Lys Ile Gly Ser Gly Leu Ala Asn Ala Val Ala Ala Ser Ser Ala Thr 
    530                 535                 540                 


Val Phe Pro Thr Val Val Asp Ala Pro Asp Glu Thr Arg Pro Lys Ala 
545                 550                 555                 560 


Asp Leu Gly Asp Gly Thr Glu Gly Trp Thr Phe Ser Ile Arg Leu Thr 
                565                 570                 575     


Asn Thr Ala Tyr Glu Ala Arg Thr Tyr Arg Leu Asn Thr Gln Ala Leu 
            580                 585                 590         


Ser Glu Val Val Ala Ser Gly Val Phe Thr Gln His Ser Ala Asn Trp 
        595                 600                 605             


Thr Asp Gln Gly Ile Ser Val Ser Tyr Ser Gly Asp Val Ser Gly Ser 
    610                 615                 620                 


Ala Asp Ser Ser Thr Ile Thr Val Pro Gly Arg Gly Val Val Thr Ala 
625                 630                 635                 640 


Thr Val Thr Ile Thr Pro Gln Ala Ala Phe Ala Ala Tyr Ala Gly Ala 
                645                 650                 655     


Tyr Ala Pro Asn Gly Thr Phe Val Asp Gly Phe Thr Val Leu Thr Ser 
            660                 665                 670         


Met Thr Glu Gly Glu Pro Asp Leu Ser Val Pro Phe Leu Gly Phe Tyr 
        675                 680                 685             


Gly Asp Trp Gly Ala Val Pro Val Phe Asp Ser Leu Ala Ser Asp Gly 
    690                 695                 700                 


Gly Gln Ala His Ala Val Ala Ser Arg Leu Ala Ser Ala Thr Thr Gly 
705                 710                 715                 720 


Val Ser Leu Gly Val Asn Pro Leu Ala Gly Tyr Thr Ser Ala Ser Ser 
                725                 730                 735     


Ala Pro Ala Pro Asn Pro Asp Ala Tyr Val Val Ser Ala Ser Thr Trp 
            740                 745                 750         


Ala Gln Gly Pro Ser Ala Ile Arg Pro Val Thr Gly Leu Leu Arg Ser 
        755                 760                 765             


Thr Lys Ser Val Thr Tyr Thr Tyr Gln Asp Ser Ala Gly Asn Thr Val 
    770                 775                 780                 


Arg Gln Tyr Ser Tyr Lys Asn Thr Arg Lys Ser Leu Tyr Asp Asp Tyr 
785                 790                 795                 800 


Thr Arg Leu Ile Ala Ser Gly Glu Ser Ser Met Gly Asp Pro Tyr Phe 
                805                 810                 815     


Asp Gly Tyr Asp Trp Tyr Gly Arg Arg Leu Pro Glu Gly Arg Tyr Thr 
            820                 825                 830         


Leu Arg Ile Asp Ala Val Thr Asp Gly Pro Ser Leu Arg Thr Gln Thr 
        835                 840                 845             


Leu Thr Tyr Ser Phe Ala Tyr Asp Leu Thr Gly Pro Lys Ile Ser Gly 
    850                 855                 860                 


Val His Val Ser Gly Gln Gly Glu Ala Arg Thr Val Ser Phe Asp Val 
865                 870                 875                 880 


Thr Asp Ser Ser Pro Leu Ala Ser Ile Asp Phe His Asp Pro Ala Asn 
                885                 890                 895     


Gly Ser Tyr Tyr Tyr Arg Thr Leu Val Thr Asp Gly Gly Thr Leu Gly 
            900                 905                 910         


Ala Asp Gly Gln Arg Thr Tyr His Phe Asp Val Pro Val Ala Asp Leu 
        915                 920                 925             


Gln Arg Gly Trp Glu Ser Gln Gly Gly Thr Gly Pro Ala Pro Thr Asn 
    930                 935                 940                 


Pro Thr Leu Tyr Ala Trp Asp Tyr Gly Val Asn Ala Ser Ala Gly Val 
945                 950                 955                 960 


Thr Val Ser Val Asp Ala Ser Asp Pro Ile Ser Leu Ser Thr Ser Ser 
                965                 970                 975     


Val Val Ile Pro Ser Gly Glu Thr Ser Gln Val Phe Ala Val Leu Ser 
            980                 985                 990         


Pro Ser Leu Ser Gly Ser Gln Val  Val Trp Ser Leu Ala  Asp Ser Ser 
        995                 1000                 1005             


Val Ala  Ser Leu Ser Thr Ser  Ser Asp Thr Leu Thr  Ala Thr Ile 
    1010                 1015                 1020             


Ala Ala  Gly Thr Lys Glu Gly  Ala Thr Thr Leu Thr  Ala Trp Val 
    1025                 1030                 1035             


Arg Gln  Gly Asp Gly Thr Trp  Ala Ser Ala Ser Ala  Glu Val Ser 
    1040                 1045                 1050             


Val Arg  Ala Ala Ala Ser Ser  Asp Phe Val Ile Asp  Glu Ala Gly 
    1055                 1060                 1065             


Val Leu  Arg Ser Tyr Ser Gly  Ser Asp Thr Glu Val  Ser Val Pro 
    1070                 1075                 1080             


Gly Gly  Val Thr Ala Leu Ala  Asp Arg Val Phe Ala  Arg Ser Ser 
    1085                 1090                 1095             


Val Ala  Ser Val Glu Leu Pro  Asp Thr Val Glu Arg  Ile Gly Ala 
    1100                 1105                 1110             


Ser Ala  Phe Glu Gly Ala Ala  Ser Leu Ala Ser Val  Thr Val Arg 
    1115                 1120                 1125             


Asp Ala  Arg Gly Gln Val Gly  Glu Gly Leu Pro Ser  Gly Leu Arg 
    1130                 1135                 1140             


Gln Ile  Gly Ala Arg Ala Phe  Leu Gly Thr Gly Leu  Ala Val Ile 
    1145                 1150                 1155             


Asn Val  Pro Asp Ser Val Ser  Asp Ile Gly Pro Gly  Ala Phe Ala 
    1160                 1165                 1170             


Leu Met  Pro Ser Leu Thr Gly  Val Asn Ile Gly Ser  Gly Val Arg 
    1175                 1180                 1185             


Glu Gly  Gln Leu Val Ser Thr  Phe Thr Ala Ser Pro  Lys Leu Lys 
    1190                 1195                 1200             


Ala Ile  Thr Val Lys Ala Asp  Asn Ala Ser Tyr Asp  Ser Val Asp 
    1205                 1210                 1215             


Gly Val  Leu Phe Thr Lys Gly  Arg Asp Thr Leu Leu  Thr Tyr Pro 
    1220                 1225                 1230             


Leu Gly  Arg Ala Gly Val Ser  Tyr Thr Val Pro Asp  Gly Thr Arg 
    1235                 1240                 1245             


Ala Leu  Ala Gln Glu Ser Phe  Glu Gly Ala Pro Leu  Asp Glu Val 
    1250                 1255                 1260             


Thr Leu  Pro Asp Ser Leu Arg  Arg Ile Asp Arg Tyr  Ala Phe Val 
    1265                 1270                 1275             


Gly Ser  Arg Leu Ser Ser Leu  Thr Leu Pro Asp Ser  Phe Glu Met 
    1280                 1285                 1290             


Ile Gly  Ala His Ala Phe Arg  Gly Val Thr Ser Leu  Thr Trp Val 
    1295                 1300                 1305             


Asn Ile  Gly Gly Thr Thr Thr  Ile Gly Glu Ser Ala  Phe Asp Gly 
    1310                 1315                 1320             


Asp Arg  Asn Leu Thr Ala Ile  Asn Phe Arg Ser Asp  Leu Ala Arg 
    1325                 1330                 1335             


Leu Thr  Ser Ile Gly Ala Asn  Ala Leu Arg Gly Val  Pro Val Thr 
    1340                 1345                 1350             


Pro Pro  Ala Leu Thr Ser Ala  Arg Ala Gln Ala Glu  Thr Pro Ala 
    1355                 1360                 1365             


Ser Asp  Thr Ala Ser Gly Asn  Ala Pro Thr Pro Ala  Pro Ile Ala 
    1370                 1375                 1380             


Ser Pro  Glu Ala Thr Gly Ser  Asp Ser Ala Ser Asp  Asp Arg Ala 
    1385                 1390                 1395             


Thr Gly  Gly Asp Ala Ala Pro  Ala Thr Pro Asn Pro  Asn Ala Ser 
    1400                 1405                 1410             


Ala Ser  Ala Ser Pro Asp Ala  Pro Asp Gln Gly Gln  Gly Ser Glu 
    1415                 1420                 1425             


Ala Pro  Gln Ser Ser Ala Ala  Pro Ala Ala Ser Thr  Arg Ala Pro 
    1430                 1435                 1440             


Gly Ala  Ala Ala Ser Ser Pro  Ala Ala Val Gly Gln  Pro Val Ser 
    1445                 1450                 1455             


Val Val  Gly Arg Thr Ala Leu  Ser Leu Gly Asp Ala  Ala Asp Tyr 
    1460                 1465                 1470             


His Ala  Pro His Pro Lys Arg  Thr Arg Pro Ser Ser  Leu Ala Ala 
    1475                 1480                 1485             


Thr Gly  Ala Ser Thr Asn Gly  Phe Val Gly Ile Leu  Thr Ala Ala 
    1490                 1495                 1500             


Ala Thr  Leu Gly Phe Val Leu  Val Val Ala Arg Arg  Gln Arg Leu 
    1505                 1510                 1515             


Ser 
    


<210>  50
<211>  1492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Actinomyces sp. oral taxon 180 str. F0310 protease

<400>  50

Ser Ala Asp Thr Leu Val Ser Ala Pro Ala Ser Pro Pro Ser Ser Asn 
1               5                   10                  15      


Ala Gly Lys Leu Leu Glu Pro Glu Leu Thr Ser Lys Ser Gln Tyr Asp 
            20                  25                  30          


Ala Gly Gly Ala Thr Thr Pro Ser Gly Asp Leu Leu Pro Asp Glu Glu 
        35                  40                  45              


Ser Asn His Pro Val Thr Val Ile Val Glu Leu Glu Glu Gly Asp Ala 
    50                  55                  60                  


Gly Val Ala Trp Tyr Arg Arg Ala Val Ser Ala Asp Ala Lys Arg Thr 
65                  70                  75                  80  


Val Val Lys Glu Arg Ile Arg Thr Ala Val Glu Ala Ala Ala Pro Gly 
                85                  90                  95      


Gln Val Thr Ser Gly Gly Gly Pro Val Thr Glu Val Glu Asp Tyr Glu 
            100                 105                 110         


His Val Met Glu Gly Phe Ala Ile Glu Val Pro Ala Gly Ala Val Glu 
        115                 120                 125             


Ala Val Arg Gly Val Glu Gly Val Lys Arg Ala Phe Val Glu Gln Thr 
    130                 135                 140                 


Val Thr Pro Ser Ser Glu Glu Gly Tyr Ser Gly Pro Gln Asn Gln Tyr 
145                 150                 155                 160 


Ser Leu Asp Met Thr Gly Val Asp Arg Ile Ser Gln Lys Gly Asp Gly 
                165                 170                 175     


Thr Thr Ile Ala Ile Ile Asp Thr Gly Phe Asp Thr Thr His Glu Ala 
            180                 185                 190         


Phe Ser Gly Ala Leu Asp Glu Ser Arg Ala Ala Tyr Ser Tyr Asp Ser 
        195                 200                 205             


Ile Ser Ser Val Lys Arg Gly Leu Ser Thr Gly Trp Ala Gly Ala Tyr 
    210                 215                 220                 


Val Ser Ala Lys Ile Pro Phe Ala Tyr Asp Tyr Gly Asp Gly Asp Ser 
225                 230                 235                 240 


Asp Val Ile Pro His Thr Val His Asn Met Ala His Gly Thr His Val 
                245                 250                 255     


Ala Gly Ile Ala Ala Ala Asn Gly Gly Ala Ile Leu Gly Ser Ala Pro 
            260                 265                 270         


Gly Ala Gln Leu Leu Leu Met Lys Ala Gly Ile Asp Ala Thr Gly Gly 
        275                 280                 285             


Leu Ser Asp Ser Ala Ile Phe Ala Ala Leu Asp Asp Cys Ala Val Leu 
    290                 295                 300                 


Lys Pro Asp Val Ile Asn Met Ser Phe Gly Tyr Ala Gly Gly Ala Ser 
305                 310                 315                 320 


Glu Ala Arg Asn Asp Thr Tyr Gly Ser Val Tyr Tyr Arg Leu Ser Glu 
                325                 330                 335     


Gln Gly Ile Met Leu Asn Val Ala Gly Gly Asn Phe Gly Ala Ser Ser 
            340                 345                 350         


Gln Gly Asn Ala Ser Gly Trp Gly Leu Pro Tyr Ala Ser Asp Pro Asp 
        355                 360                 365             


Ser Ser Thr Val Ala Gln Pro Ser Thr Tyr Thr Ala Ser Leu Ser Val 
    370                 375                 380                 


Ala Ser Val Asp Asn Ala Asn Gly Trp Gly Pro Ser Thr Tyr Lys Ala 
385                 390                 395                 400 


Ser Ser Phe Ser Ser Trp Gly Val Ala Pro Asn Leu Thr Leu Lys Pro 
                405                 410                 415     


Glu Ile Ala Ala Pro Gly Gly Tyr Ile Trp Ser Ala Leu Pro Gly Gly 
            420                 425                 430         


Thr Tyr Gly Tyr Ser Ser Gly Thr Ser Met Ala Thr Pro Tyr Leu Ala 
        435                 440                 445             


Gly Met Ala Ala Asp Ile Lys Gln Arg Val Glu Ser Asp Pro Gly Phe 
    450                 455                 460                 


Ala Tyr Met Thr Glu Ala Gln Lys Thr Gly Val Val Tyr Asn Leu Leu 
465                 470                 475                 480 


Met Gly Thr Ala Lys Pro Leu Val Asp Asn Glu Gly Gly Arg Gly Ala 
                485                 490                 495     


Tyr Tyr Ser Pro Arg Lys Ile Gly Ser Gly Leu Ala Asn Ala Val Ala 
            500                 505                 510         


Ala Ser Ser Ala Thr Val Phe Pro Thr Val Val Asp Ala Pro Asp Glu 
        515                 520                 525             


Thr Arg Pro Lys Ala Asp Leu Gly Asp Gly Thr Glu Gly Trp Thr Phe 
    530                 535                 540                 


Ser Ile Arg Leu Thr Asn Thr Ala Tyr Glu Ala Arg Thr Tyr Arg Leu 
545                 550                 555                 560 


Asn Thr Gln Ala Leu Ser Glu Val Val Ala Ser Gly Val Phe Thr Gln 
                565                 570                 575     


His Ser Ala Asn Trp Thr Asp Gln Gly Ile Ser Val Ser Tyr Ser Gly 
            580                 585                 590         


Asp Val Ser Gly Ser Ala Asp Ser Ser Thr Ile Thr Val Pro Gly Arg 
        595                 600                 605             


Gly Val Val Thr Ala Thr Val Thr Ile Thr Pro Gln Ala Ala Phe Ala 
    610                 615                 620                 


Ala Tyr Ala Gly Ala Tyr Ala Pro Asn Gly Thr Phe Val Asp Gly Phe 
625                 630                 635                 640 


Thr Val Leu Thr Ser Met Thr Glu Gly Glu Pro Asp Leu Ser Val Pro 
                645                 650                 655     


Phe Leu Gly Phe Tyr Gly Asp Trp Gly Ala Val Pro Val Phe Asp Ser 
            660                 665                 670         


Leu Ala Ser Asp Gly Gly Gln Ala His Ala Val Ala Ser Arg Leu Ala 
        675                 680                 685             


Ser Ala Thr Thr Gly Val Ser Leu Gly Val Asn Pro Leu Ala Gly Tyr 
    690                 695                 700                 


Thr Ser Ala Ser Ser Ala Pro Ala Pro Asn Pro Asp Ala Tyr Val Val 
705                 710                 715                 720 


Ser Ala Ser Thr Trp Ala Gln Gly Pro Ser Ala Ile Arg Pro Val Thr 
                725                 730                 735     


Gly Leu Leu Arg Ser Thr Lys Ser Val Thr Tyr Thr Tyr Gln Asp Ser 
            740                 745                 750         


Ala Gly Asn Thr Val Arg Gln Tyr Ser Tyr Lys Asn Thr Arg Lys Ser 
        755                 760                 765             


Leu Tyr Asp Asp Tyr Thr Arg Leu Ile Ala Ser Gly Glu Ser Ser Met 
    770                 775                 780                 


Gly Asp Pro Tyr Phe Asp Gly Tyr Asp Trp Tyr Gly Arg Arg Leu Pro 
785                 790                 795                 800 


Glu Gly Arg Tyr Thr Leu Arg Ile Asp Ala Val Thr Asp Gly Pro Ser 
                805                 810                 815     


Leu Arg Thr Gln Thr Leu Thr Tyr Ser Phe Ala Tyr Asp Leu Thr Gly 
            820                 825                 830         


Pro Lys Ile Ser Gly Val His Val Ser Gly Gln Gly Glu Ala Arg Thr 
        835                 840                 845             


Val Ser Phe Asp Val Thr Asp Ser Ser Pro Leu Ala Ser Ile Asp Phe 
    850                 855                 860                 


His Asp Pro Ala Asn Gly Ser Tyr Tyr Tyr Arg Thr Leu Val Thr Asp 
865                 870                 875                 880 


Gly Gly Thr Leu Gly Ala Asp Gly Gln Arg Thr Tyr His Phe Asp Val 
                885                 890                 895     


Pro Val Ala Asp Leu Gln Arg Gly Trp Glu Ser Gln Gly Gly Thr Gly 
            900                 905                 910         


Pro Ala Pro Thr Asn Pro Thr Leu Tyr Ala Trp Asp Tyr Gly Val Asn 
        915                 920                 925             


Ala Ser Ala Gly Val Thr Val Ser Val Asp Ala Ser Asp Pro Ile Ser 
    930                 935                 940                 


Leu Ser Thr Ser Ser Val Val Ile Pro Ser Gly Glu Thr Ser Gln Val 
945                 950                 955                 960 


Phe Ala Val Leu Ser Pro Ser Leu Ser Gly Ser Gln Val Val Trp Ser 
                965                 970                 975     


Leu Ala Asp Ser Ser Val Ala Ser Leu Ser Thr Ser Ser Asp Thr Leu 
            980                 985                 990         


Thr Ala Thr Ile Ala Ala Gly Thr  Lys Glu Gly Ala Thr  Thr Leu Thr 
        995                 1000                 1005             


Ala Trp  Val Arg Gln Gly Asp  Gly Thr Trp Ala Ser  Ala Ser Ala 
    1010                 1015                 1020             


Glu Val  Ser Val Arg Ala Ala  Ala Ser Ser Asp Phe  Val Ile Asp 
    1025                 1030                 1035             


Glu Ala  Gly Val Leu Arg Ser  Tyr Ser Gly Ser Asp  Thr Glu Val 
    1040                 1045                 1050             


Ser Val  Pro Gly Gly Val Thr  Ala Leu Ala Asp Arg  Val Phe Ala 
    1055                 1060                 1065             


Arg Ser  Ser Val Ala Ser Val  Glu Leu Pro Asp Thr  Val Glu Arg 
    1070                 1075                 1080             


Ile Gly  Ala Ser Ala Phe Glu  Gly Ala Ala Ser Leu  Ala Ser Val 
    1085                 1090                 1095             


Thr Val  Arg Asp Ala Arg Gly  Gln Val Gly Glu Gly  Leu Pro Ser 
    1100                 1105                 1110             


Gly Leu  Arg Gln Ile Gly Ala  Arg Ala Phe Leu Gly  Thr Gly Leu 
    1115                 1120                 1125             


Ala Val  Ile Asn Val Pro Asp  Ser Val Ser Asp Ile  Gly Pro Gly 
    1130                 1135                 1140             


Ala Phe  Ala Leu Met Pro Ser  Leu Thr Gly Val Asn  Ile Gly Ser 
    1145                 1150                 1155             


Gly Val  Arg Glu Gly Gln Leu  Val Ser Thr Phe Thr  Ala Ser Pro 
    1160                 1165                 1170             


Lys Leu  Lys Ala Ile Thr Val  Lys Ala Asp Asn Ala  Ser Tyr Asp 
    1175                 1180                 1185             


Ser Val  Asp Gly Val Leu Phe  Thr Lys Gly Arg Asp  Thr Leu Leu 
    1190                 1195                 1200             


Thr Tyr  Pro Leu Gly Arg Ala  Gly Val Ser Tyr Thr  Val Pro Asp 
    1205                 1210                 1215             


Gly Thr  Arg Ala Leu Ala Gln  Glu Ser Phe Glu Gly  Ala Pro Leu 
    1220                 1225                 1230             


Asp Glu  Val Thr Leu Pro Asp  Ser Leu Arg Arg Ile  Asp Arg Tyr 
    1235                 1240                 1245             


Ala Phe  Val Gly Ser Arg Leu  Ser Ser Leu Thr Leu  Pro Asp Ser 
    1250                 1255                 1260             


Phe Glu  Met Ile Gly Ala His  Ala Phe Arg Gly Val  Thr Ser Leu 
    1265                 1270                 1275             


Thr Trp  Val Asn Ile Gly Gly  Thr Thr Thr Ile Gly  Glu Ser Ala 
    1280                 1285                 1290             


Phe Asp  Gly Asp Arg Asn Leu  Thr Ala Ile Asn Phe  Arg Ser Asp 
    1295                 1300                 1305             


Leu Ala  Arg Leu Thr Ser Ile  Gly Ala Asn Ala Leu  Arg Gly Val 
    1310                 1315                 1320             


Pro Val  Thr Pro Pro Ala Leu  Thr Ser Ala Arg Ala  Gln Ala Glu 
    1325                 1330                 1335             


Thr Pro  Ala Ser Asp Thr Ala  Ser Gly Asn Ala Pro  Thr Pro Ala 
    1340                 1345                 1350             


Pro Ile  Ala Ser Pro Glu Ala  Thr Gly Ser Asp Ser  Ala Ser Asp 
    1355                 1360                 1365             


Asp Arg  Ala Thr Gly Gly Asp  Ala Ala Pro Ala Thr  Pro Asn Pro 
    1370                 1375                 1380             


Asn Ala  Ser Ala Ser Ala Ser  Pro Asp Ala Pro Asp  Gln Gly Gln 
    1385                 1390                 1395             


Gly Ser  Glu Ala Pro Gln Ser  Ser Ala Ala Pro Ala  Ala Ser Thr 
    1400                 1405                 1410             


Arg Ala  Pro Gly Ala Ala Ala  Ser Ser Pro Ala Ala  Val Gly Gln 
    1415                 1420                 1425             


Pro Val  Ser Val Val Gly Arg  Thr Ala Leu Ser Leu  Gly Asp Ala 
    1430                 1435                 1440             


Ala Asp  Tyr His Ala Pro His  Pro Lys Arg Thr Arg  Pro Ser Ser 
    1445                 1450                 1455             


Leu Ala  Ala Thr Gly Ala Ser  Thr Asn Gly Phe Val  Gly Ile Leu 
    1460                 1465                 1470             


Thr Ala  Ala Ala Thr Leu Gly  Phe Val Leu Val Val  Ala Arg Arg 
    1475                 1480                 1485             


Gln Arg  Leu Ser 
    1490         


<210>  51
<211>  1532
<212>  PRT
<213>  Erysipelothrix rhusiopathiae

<400>  51

Met Arg Lys Arg Phe Lys Ala Met Met Pro Leu Val Leu Ser Leu Leu 
1               5                   10                  15      


Leu Val Ile Thr Thr Gly Thr Asn Ile Arg Ala Asn Asp Glu Gly Thr 
            20                  25                  30          


Leu Ala Glu Leu Thr Ala Met Asp Asp Val Ser Ile Val Gln Ser Ile 
        35                  40                  45              


Leu Asp Glu Glu Glu Thr Asn Thr Pro Glu Glu Asp Pro Glu Leu Ser 
    50                  55                  60                  


Val Asp Pro Ser Val Pro Val Asp Ile Ile Val Glu Leu Glu Ala Arg 
65                  70                  75                  80  


Pro Ile Leu Asp Tyr Glu Asn Glu Ile Lys Gln Val Gly Ser Leu Gly 
                85                  90                  95      


Asp Phe Ser Glu Thr Lys Gln Ala Gln Asp Leu Glu Ala Asn Leu Ile 
            100                 105                 110         


Lys Ser His Glu Ala Val Val Asp Lys Ile Ser Glu Val Ile Gln Lys 
        115                 120                 125             


Asp Val Glu Val Asp Ser Asn Phe Thr Arg Val Met Asn Gly Phe Ser 
    130                 135                 140                 


Leu Lys Ala Ser Leu Asp Asp Leu Asn Leu Ile Lys Asp Ile Glu Gly 
145                 150                 155                 160 


Val Lys Ser Ala Phe Val Ser Gln Thr Tyr Asp Ile Pro Glu Pro Gln 
                165                 170                 175     


Met Val Asp Ser Asn Arg Thr Ile Gly Ser Asp Thr Val Trp Thr Gln 
            180                 185                 190         


Ser His Tyr Lys Gly Glu Asn Ile Val Val Ala Val Leu Asp Thr Gly 
        195                 200                 205             


Leu Asp Thr Gly His Pro Ala Phe Ala Val Ala Pro Ser Gln Phe Arg 
    210                 215                 220                 


Ile Asn Lys Gln Lys Ile Gln Thr Val Leu Asn Asn Lys Lys Leu Lys 
225                 230                 235                 240 


Ala Thr Ala Asn Thr Pro Gly Leu Thr Val Asp His Val Tyr Ile Asn 
                245                 250                 255     


Asp Lys Val Pro Phe Val Tyr Asp Tyr Ala Asp Lys Asp Ala Ile Val 
            260                 265                 270         


Asp Pro Ser Ala His Asn Tyr Gly Arg Leu Ala His Gly Thr His Val 
        275                 280                 285             


Ala Gly Thr Val Ala Gly Lys Asp Gln Ala Asp Phe Arg Gly Val Ala 
    290                 295                 300                 


Pro Glu Ala Gln Leu Met Ile Phe Lys Val Phe Ser Asp Lys Gly Gly 
305                 310                 315                 320 


Gly Ala Ser Asp Ile Ser Leu Val Ser Ala Leu Glu Asp Cys Val Tyr 
                325                 330                 335     


Leu Gly Val Asp Val Ile Asn Met Ser Leu Gly Ser Asp Ala Gly Phe 
            340                 345                 350         


Met His Asp Ser Tyr Lys Pro Thr Asn Asp Met Tyr Asn Arg Ile Arg 
        355                 360                 365             


Asp Asn Gly Ile Val Leu Asp Val Ala Ala Gly Asn Ala Met Ser Ser 
    370                 375                 380                 


Ser Glu Lys Asn Leu Tyr Gly Asn Asp Leu Thr Leu Ala Ser Asp Pro 
385                 390                 395                 400 


Asp His Gly Ile Val Gly Ser Pro Ser Thr Tyr Ala Ser Pro Ile Ser 
                405                 410                 415     


Val Ala Ser Val Asn Asn Thr Lys Tyr Arg Pro Gly Ser Lys Thr Ile 
            420                 425                 430         


Asp Pro Thr Gln Val Thr Leu Ser Gly Phe Ser Ser Ile Gly Thr Thr 
        435                 440                 445             


Pro Asn Ile Ser Ile Lys Pro Glu Ile Ser Ala Pro Gly Ala Trp Ile 
    450                 455                 460                 


Arg Ser Ala Met Pro Arg Leu Asn Gly Gln Asn Tyr Asp Glu Met Ser 
465                 470                 475                 480 


Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala Ser Ala Leu Met 
                485                 490                 495     


Lys Gln Tyr Leu Asn Asp Lys Phe Gly Asn Leu Thr Asn Ile Gln Lys 
            500                 505                 510         


Met Glu Leu Thr Asn Asn Leu Leu Met Ser Thr Ala His Pro Ile Val 
        515                 520                 525             


Gln Lys Asp Gly Ala Pro Gln Pro Val Arg Lys Gln Gly Ser Gly Met 
    530                 535                 540                 


Met Asp Ile Asn Ala Ala Ile Lys Thr Pro Val Tyr Leu Ser Val Asp 
545                 550                 555                 560 


Pro Lys Gln Asn His Asp Gly Ser Asn Arg Pro Lys Ile Glu Leu Gly 
                565                 570                 575     


Asp Asp Gln Asn Lys Thr Gly Asn Tyr Thr Leu Lys Phe Lys Val Thr 
            580                 585                 590         


Asn Met Gly Thr Gln Thr Glu Thr Tyr Gln Ile Lys Glu Lys Val Ser 
        595                 600                 605             


Val Pro Val Ile Lys Arg Ser Ile Met Asp Asp His Arg Glu Arg Ala 
    610                 615                 620                 


Phe Met Thr Asp Asp Asn Arg Ser Val Asp Val Thr Arg Ser Gly Val 
625                 630                 635                 640 


Thr Ser Val Thr Val Lys Ala Lys Glu Thr Lys Asp Val Ser Ile Thr 
                645                 650                 655     


Val Gln Leu Thr Gln Ala Glu Lys Asn Arg Leu Asn Gln Glu Phe Glu 
            660                 665                 670         


Asn Gly Thr Tyr Val Glu Gly Phe Val Gln Leu Thr His Ala Ser His 
        675                 680                 685             


Pro Gln Ile Ser Ile Pro Phe Leu Ala Phe Tyr Gly Asp Trp Glu Lys 
    690                 695                 700                 


Ala Pro Ile Phe Asp His Ala Ala Glu Tyr Glu Met Gly Val Arg Ala 
705                 710                 715                 720 


Ser Asn Tyr Ala His Arg Tyr Leu Ser Asp Lys Met Pro Met Gly Gly 
                725                 730                 735     


Asn Ile Phe Asp Arg Arg Met Ile Tyr Thr Asn Pro Ser Arg Phe Val 
            740                 745                 750         


Ile Ser Pro Asn Gly Asp Gly Leu Tyr Asp Lys Leu Ser Gly Ile Asn 
        755                 760                 765             


Leu Gly Gln Leu Arg Asn Val Glu Ser Met Thr Met Glu Ile Thr Asn 
    770                 775                 780                 


Lys Lys Thr Lys Gln Val Ile Ile Lys Glu Glu Arg Pro Asn Ile Arg 
785                 790                 795                 800 


Lys Thr Phe Tyr Asn Asn Ser Tyr Gly Lys Gln Val Pro Asn Ile Leu 
                805                 810                 815     


Phe Trp Pro Phe Ser Thr Phe Thr Gly Leu Asp Gln Gln Lys Asn Pro 
            820                 825                 830         


Leu Pro Glu Gly Arg Tyr Asp Leu Lys Ile Ser Ala Asp Leu Gly Tyr 
        835                 840                 845             


Arg Lys Gly Ile Asp Gln Glu Ile Val His Thr Ile His Val Asp His 
    850                 855                 860                 


Thr Lys Pro Val Ile Pro Gln Asp Lys Ile Lys Phe Thr Glu Lys Asn 
865                 870                 875                 880 


Gly Thr Val Met Met His Val Glu Ser Asn Asp Asn Thr Phe Leu Thr 
                885                 890                 895     


Gln Thr Ala Leu Tyr Pro Val Tyr Asn Gly Lys Val Gln Val Asn Arg 
            900                 905                 910         


Pro Leu Lys Lys Gln Tyr Thr Pro Tyr Asp Leu Val Ser Arg His Ala 
        915                 920                 925             


Phe Asp Val Asp Val Thr Asn Leu Lys Gly Gln Glu Val Val Ile Ser 
    930                 935                 940                 


Ala Val Asp Ala Gly Met Leu Glu Thr Asn Tyr Lys Thr Val Val Pro 
945                 950                 955                 960 


Gly Thr Pro Lys Pro His Leu Lys Val Asp Glu Phe Lys Ile Lys Val 
                965                 970                 975     


Gly Ala Gln Ile Glu Leu Glu Pro Gly Asn Phe Lys Trp Gln Thr Pro 
            980                 985                 990         


Thr Phe Glu Ser Glu Asp Pro Glu  Ile Ala Asp Val Asn  Asp Lys Gly 
        995                 1000                 1005             


Leu Val  Thr Gly Leu Lys Pro  Gly Ala Thr Phe Ile  Lys Ile Lys 
    1010                 1015                 1020             


Asp Lys  Asn Gly Ile Asp Leu  Val Ala Leu Ile Glu  Val Phe Glu 
    1025                 1030                 1035             


Glu Glu  Ser Leu Lys Leu Gln  Met Lys Val Gly Glu  Lys Arg Lys 
    1040                 1045                 1050             


Leu Ile  Ser Tyr Asn Leu Glu  Gly Lys Arg Thr Phe  Asp Ser Asp 
    1055                 1060                 1065             


Ala Pro  His Ile Val Ser Ala  Arg Asp Thr Gly Glu  Ile Glu Ala 
    1070                 1075                 1080             


His Gln  Lys Gly Lys Ala Lys  Ile Thr Val Gln Asn  Ala Tyr Glu 
    1085                 1090                 1095             


Lys Leu  Glu Tyr Glu Val Glu  Val Val Asp Gln Pro  Lys Tyr Thr 
    1100                 1105                 1110             


Pro Ser  Leu Ser Phe Asp Lys  Lys Val Tyr Glu Ile  Asn Ser Gly 
    1115                 1120                 1125             


Glu Val  Val Ala Pro Lys Phe  Thr Ile Glu Asn Asp  Asp Pro Ser 
    1130                 1135                 1140             


Asn Pro  Gln Val Val Thr Arg  Leu Leu Thr Ser Asn  Glu Glu His 
    1145                 1150                 1155             


Val Ser  Ile Ala Gly Leu Lys  Phe Thr Gly Glu His  Ala Gly Glu 
    1160                 1165                 1170             


Ala Ala  Val Ile Ala Glu Leu  Lys Asn Gly Thr Arg  Ala Val Ala 
    1175                 1180                 1185             


Lys Val  Lys Val Gly Gly Leu  Asp Thr Lys Lys Leu  Asp Ile Leu 
    1190                 1195                 1200             


Ile Ser  Gln Ala Ser Asn Leu  Asn Ala Asp Asp Tyr  Thr Lys Thr 
    1205                 1210                 1215             


Ser Phe  Thr Thr Leu Thr Thr  Thr Leu Gln Glu Ala  Lys Thr Leu 
    1220                 1225                 1230             


Arg Lys  Gln Lys Gly Ile Asp  Gln Ser Asn Ile Asp  Thr Met Val 
    1235                 1240                 1245             


Glu Lys  Leu Glu Lys Ser Met  Asn Gln Leu Val Gln  Val Ile Lys 
    1250                 1255                 1260             


Asn Leu  Pro Ser Ala Met Ser  Val Glu Val Gly Asn  Thr Phe Lys 
    1265                 1270                 1275             


Leu Ser  Pro Lys Pro Ala Gln  Gly Lys Trp Ile Trp  Asp Ala Glu 
    1280                 1285                 1290             


Phe Leu  Glu Gly Thr Ala Gln  Asn Asn Asp Gln Glu  Met Met Phe 
    1295                 1300                 1305             


Lys Gly  Leu Lys Glu Gly Gln  Thr Asp Val Arg Tyr  Arg Thr Lys 
    1310                 1315                 1320             


Asp Gly  Glu Glu Gln Ser Val  Ala Val Ala Val Lys  Pro Lys Pro 
    1325                 1330                 1335             


Lys Pro  Val Glu Ile Asp Pro  Ile Val Pro Thr Asp  Pro Val Asp 
    1340                 1345                 1350             


Pro Val  Lys Pro Thr Asp Pro  Val Asp Pro Val Lys  Pro Lys Asp 
    1355                 1360                 1365             


Pro Val  Asp Pro Val Lys Pro  Thr Asp Pro Val Asp  Pro Val Lys 
    1370                 1375                 1380             


Pro Thr  Asp Pro Val Asp Pro  Val Lys Pro Thr Asp  Pro Val Asp 
    1385                 1390                 1395             


Pro Val  Lys Pro Thr Asp Pro  Val Asp Pro Val Lys  Pro Thr Asp 
    1400                 1405                 1410             


Pro Val  Asp Pro Val Lys Pro  Thr Asp Pro Val Asp  Pro Val Lys 
    1415                 1420                 1425             


Pro Thr  Asp Pro Val Asp Pro  Val Lys Pro Ala Asp  Pro Val Asp 
    1430                 1435                 1440             


Pro Val  Lys Pro Thr Asp Pro  Thr Lys Pro Thr Lys  Pro Val Asp 
    1445                 1450                 1455             


Ser Gly  Leu Lys Pro Ile Asp  Asn Leu Lys Lys Pro  Ile Val Lys 
    1460                 1465                 1470             


Pro Lys  Asp Pro Val Ser Gln  Val Glu Ser Ile Lys  Gln Asp Lys 
    1475                 1480                 1485             


Pro Val  Ile His Phe Gly Val  Val Ser Glu Ser Leu  Pro Gln Thr 
    1490                 1495                 1500             


Gly Val  Thr Pro Gln Tyr Arg  Gly Tyr Thr Leu Leu  Gly Leu Gly 
    1505                 1510                 1515             


Leu Val  Ile Arg Val Ile Asn  Asp Lys Lys Asn Arg  Met Lys 
    1520                 1525                 1530         


<210>  52
<211>  1504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Erysipelothrix rhusiopathiae ATCC 19414 protease

<400>  52

Asp Glu Gly Thr Leu Ala Glu Leu Thr Ala Met Asp Asp Val Ser Ile 
1               5                   10                  15      


Val Gln Ser Ile Leu Asp Glu Glu Glu Thr Asn Thr Pro Glu Glu Asp 
            20                  25                  30          


Pro Glu Leu Ser Val Asp Pro Ser Val Pro Val Asp Ile Ile Val Glu 
        35                  40                  45              


Leu Glu Ala Arg Pro Ile Leu Asp Tyr Glu Asn Glu Ile Lys Gln Val 
    50                  55                  60                  


Gly Ser Leu Gly Asp Phe Ser Glu Thr Lys Gln Ala Gln Asp Leu Glu 
65                  70                  75                  80  


Ala Asn Leu Ile Lys Ser His Glu Ala Val Val Asp Lys Ile Ser Glu 
                85                  90                  95      


Val Ile Gln Lys Asp Val Glu Val Asp Ser Asn Phe Thr Arg Val Met 
            100                 105                 110         


Asn Gly Phe Ser Leu Lys Ala Ser Leu Asp Asp Leu Asn Leu Ile Lys 
        115                 120                 125             


Asp Ile Glu Gly Val Lys Ser Ala Phe Val Ser Gln Thr Tyr Asp Ile 
    130                 135                 140                 


Pro Glu Pro Gln Met Val Asp Ser Asn Arg Thr Ile Gly Ser Asp Thr 
145                 150                 155                 160 


Val Trp Thr Gln Ser His Tyr Lys Gly Glu Asn Ile Val Val Ala Val 
                165                 170                 175     


Leu Asp Thr Gly Leu Asp Thr Gly His Pro Ala Phe Ala Val Ala Pro 
            180                 185                 190         


Ser Gln Phe Arg Ile Asn Lys Gln Lys Ile Gln Thr Val Leu Asn Asn 
        195                 200                 205             


Lys Lys Leu Lys Ala Thr Ala Asn Thr Pro Gly Leu Thr Val Asp His 
    210                 215                 220                 


Val Tyr Ile Asn Asp Lys Val Pro Phe Val Tyr Asp Tyr Ala Asp Lys 
225                 230                 235                 240 


Asp Ala Ile Val Asp Pro Ser Ala His Asn Tyr Gly Arg Leu Ala His 
                245                 250                 255     


Gly Thr His Val Ala Gly Thr Val Ala Gly Lys Asp Gln Ala Asp Phe 
            260                 265                 270         


Arg Gly Val Ala Pro Glu Ala Gln Leu Met Ile Phe Lys Val Phe Ser 
        275                 280                 285             


Asp Lys Gly Gly Gly Ala Ser Asp Ile Ser Leu Val Ser Ala Leu Glu 
    290                 295                 300                 


Asp Cys Val Tyr Leu Gly Val Asp Val Ile Asn Met Ser Leu Gly Ser 
305                 310                 315                 320 


Asp Ala Gly Phe Met His Asp Ser Tyr Lys Pro Thr Asn Asp Met Tyr 
                325                 330                 335     


Asn Arg Ile Arg Asp Asn Gly Ile Val Leu Asp Val Ala Ala Gly Asn 
            340                 345                 350         


Ala Met Ser Ser Ser Glu Lys Asn Leu Tyr Gly Asn Asp Leu Thr Leu 
        355                 360                 365             


Ala Ser Asp Pro Asp His Gly Ile Val Gly Ser Pro Ser Thr Tyr Ala 
    370                 375                 380                 


Ser Pro Ile Ser Val Ala Ser Val Asn Asn Thr Lys Tyr Arg Pro Gly 
385                 390                 395                 400 


Ser Lys Thr Ile Asp Pro Thr Gln Val Thr Leu Ser Gly Phe Ser Ser 
                405                 410                 415     


Ile Gly Thr Thr Pro Asn Ile Ser Ile Lys Pro Glu Ile Ser Ala Pro 
            420                 425                 430         


Gly Ala Trp Ile Arg Ser Ala Met Pro Arg Leu Asn Gly Gln Asn Tyr 
        435                 440                 445             


Asp Glu Met Ser Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
    450                 455                 460                 


Ser Ala Leu Met Lys Gln Tyr Leu Asn Asp Lys Phe Gly Asn Leu Thr 
465                 470                 475                 480 


Asn Ile Gln Lys Met Glu Leu Thr Asn Asn Leu Leu Met Ser Thr Ala 
                485                 490                 495     


His Pro Ile Val Gln Lys Asp Gly Ala Pro Gln Pro Val Arg Lys Gln 
            500                 505                 510         


Gly Ser Gly Met Met Asp Ile Asn Ala Ala Ile Lys Thr Pro Val Tyr 
        515                 520                 525             


Leu Ser Val Asp Pro Lys Gln Asn His Asp Gly Ser Asn Arg Pro Lys 
    530                 535                 540                 


Ile Glu Leu Gly Asp Asp Gln Asn Lys Thr Gly Asn Tyr Thr Leu Lys 
545                 550                 555                 560 


Phe Lys Val Thr Asn Met Gly Thr Gln Thr Glu Thr Tyr Gln Ile Lys 
                565                 570                 575     


Glu Lys Val Ser Val Pro Val Ile Lys Arg Ser Ile Met Asp Asp His 
            580                 585                 590         


Arg Glu Arg Ala Phe Met Thr Asp Asp Asn Arg Ser Val Asp Val Thr 
        595                 600                 605             


Arg Ser Gly Val Thr Ser Val Thr Val Lys Ala Lys Glu Thr Lys Asp 
    610                 615                 620                 


Val Ser Ile Thr Val Gln Leu Thr Gln Ala Glu Lys Asn Arg Leu Asn 
625                 630                 635                 640 


Gln Glu Phe Glu Asn Gly Thr Tyr Val Glu Gly Phe Val Gln Leu Thr 
                645                 650                 655     


His Ala Ser His Pro Gln Ile Ser Ile Pro Phe Leu Ala Phe Tyr Gly 
            660                 665                 670         


Asp Trp Glu Lys Ala Pro Ile Phe Asp His Ala Ala Glu Tyr Glu Met 
        675                 680                 685             


Gly Val Arg Ala Ser Asn Tyr Ala His Arg Tyr Leu Ser Asp Lys Met 
    690                 695                 700                 


Pro Met Gly Gly Asn Ile Phe Asp Arg Arg Met Ile Tyr Thr Asn Pro 
705                 710                 715                 720 


Ser Arg Phe Val Ile Ser Pro Asn Gly Asp Gly Leu Tyr Asp Lys Leu 
                725                 730                 735     


Ser Gly Ile Asn Leu Gly Gln Leu Arg Asn Val Glu Ser Met Thr Met 
            740                 745                 750         


Glu Ile Thr Asn Lys Lys Thr Lys Gln Val Ile Ile Lys Glu Glu Arg 
        755                 760                 765             


Pro Asn Ile Arg Lys Thr Phe Tyr Asn Asn Ser Tyr Gly Lys Gln Val 
    770                 775                 780                 


Pro Asn Ile Leu Phe Trp Pro Phe Ser Thr Phe Thr Gly Leu Asp Gln 
785                 790                 795                 800 


Gln Lys Asn Pro Leu Pro Glu Gly Arg Tyr Asp Leu Lys Ile Ser Ala 
                805                 810                 815     


Asp Leu Gly Tyr Arg Lys Gly Ile Asp Gln Glu Ile Val His Thr Ile 
            820                 825                 830         


His Val Asp His Thr Lys Pro Val Ile Pro Gln Asp Lys Ile Lys Phe 
        835                 840                 845             


Thr Glu Lys Asn Gly Thr Val Met Met His Val Glu Ser Asn Asp Asn 
    850                 855                 860                 


Thr Phe Leu Thr Gln Thr Ala Leu Tyr Pro Val Tyr Asn Gly Lys Val 
865                 870                 875                 880 


Gln Val Asn Arg Pro Leu Lys Lys Gln Tyr Thr Pro Tyr Asp Leu Val 
                885                 890                 895     


Ser Arg His Ala Phe Asp Val Asp Val Thr Asn Leu Lys Gly Gln Glu 
            900                 905                 910         


Val Val Ile Ser Ala Val Asp Ala Gly Met Leu Glu Thr Asn Tyr Lys 
        915                 920                 925             


Thr Val Val Pro Gly Thr Pro Lys Pro His Leu Lys Val Asp Glu Phe 
    930                 935                 940                 


Lys Ile Lys Val Gly Ala Gln Ile Glu Leu Glu Pro Gly Asn Phe Lys 
945                 950                 955                 960 


Trp Gln Thr Pro Thr Phe Glu Ser Glu Asp Pro Glu Ile Ala Asp Val 
                965                 970                 975     


Asn Asp Lys Gly Leu Val Thr Gly Leu Lys Pro Gly Ala Thr Phe Ile 
            980                 985                 990         


Lys Ile Lys Asp Lys Asn Gly Ile  Asp Leu Val Ala Leu  Ile Glu Val 
        995                 1000                 1005             


Phe Glu  Glu Glu Ser Leu Lys  Leu Gln Met Lys Val  Gly Glu Lys 
    1010                 1015                 1020             


Arg Lys  Leu Ile Ser Tyr Asn  Leu Glu Gly Lys Arg  Thr Phe Asp 
    1025                 1030                 1035             


Ser Asp  Ala Pro His Ile Val  Ser Ala Arg Asp Thr  Gly Glu Ile 
    1040                 1045                 1050             


Glu Ala  His Gln Lys Gly Lys  Ala Lys Ile Thr Val  Gln Asn Ala 
    1055                 1060                 1065             


Tyr Glu  Lys Leu Glu Tyr Glu  Val Glu Val Val Asp  Gln Pro Lys 
    1070                 1075                 1080             


Tyr Thr  Pro Ser Leu Ser Phe  Asp Lys Lys Val Tyr  Glu Ile Asn 
    1085                 1090                 1095             


Ser Gly  Glu Val Val Ala Pro  Lys Phe Thr Ile Glu  Asn Asp Asp 
    1100                 1105                 1110             


Pro Ser  Asn Pro Gln Val Val  Thr Arg Leu Leu Thr  Ser Asn Glu 
    1115                 1120                 1125             


Glu His  Val Ser Ile Ala Gly  Leu Lys Phe Thr Gly  Glu His Ala 
    1130                 1135                 1140             


Gly Glu  Ala Ala Val Ile Ala  Glu Leu Lys Asn Gly  Thr Arg Ala 
    1145                 1150                 1155             


Val Ala  Lys Val Lys Val Gly  Gly Leu Asp Thr Lys  Lys Leu Asp 
    1160                 1165                 1170             


Ile Leu  Ile Ser Gln Ala Ser  Asn Leu Asn Ala Asp  Asp Tyr Thr 
    1175                 1180                 1185             


Lys Thr  Ser Phe Thr Thr Leu  Thr Thr Thr Leu Gln  Glu Ala Lys 
    1190                 1195                 1200             


Thr Leu  Arg Lys Gln Lys Gly  Ile Asp Gln Ser Asn  Ile Asp Thr 
    1205                 1210                 1215             


Met Val  Glu Lys Leu Glu Lys  Ser Met Asn Gln Leu  Val Gln Val 
    1220                 1225                 1230             


Ile Lys  Asn Leu Pro Ser Ala  Met Ser Val Glu Val  Gly Asn Thr 
    1235                 1240                 1245             


Phe Lys  Leu Ser Pro Lys Pro  Ala Gln Gly Lys Trp  Ile Trp Asp 
    1250                 1255                 1260             


Ala Glu  Phe Leu Glu Gly Thr  Ala Gln Asn Asn Asp  Gln Glu Met 
    1265                 1270                 1275             


Met Phe  Lys Gly Leu Lys Glu  Gly Gln Thr Asp Val  Arg Tyr Arg 
    1280                 1285                 1290             


Thr Lys  Asp Gly Glu Glu Gln  Ser Val Ala Val Ala  Val Lys Pro 
    1295                 1300                 1305             


Lys Pro  Lys Pro Val Glu Ile  Asp Pro Ile Val Pro  Thr Asp Pro 
    1310                 1315                 1320             


Val Asp  Pro Val Lys Pro Thr  Asp Pro Val Asp Pro  Val Lys Pro 
    1325                 1330                 1335             


Lys Asp  Pro Val Asp Pro Val  Lys Pro Thr Asp Pro  Val Asp Pro 
    1340                 1345                 1350             


Val Lys  Pro Thr Asp Pro Val  Asp Pro Val Lys Pro  Thr Asp Pro 
    1355                 1360                 1365             


Val Asp  Pro Val Lys Pro Thr  Asp Pro Val Asp Pro  Val Lys Pro 
    1370                 1375                 1380             


Thr Asp  Pro Val Asp Pro Val  Lys Pro Thr Asp Pro  Val Asp Pro 
    1385                 1390                 1395             


Val Lys  Pro Thr Asp Pro Val  Asp Pro Val Lys Pro  Ala Asp Pro 
    1400                 1405                 1410             


Val Asp  Pro Val Lys Pro Thr  Asp Pro Thr Lys Pro  Thr Lys Pro 
    1415                 1420                 1425             


Val Asp  Ser Gly Leu Lys Pro  Ile Asp Asn Leu Lys  Lys Pro Ile 
    1430                 1435                 1440             


Val Lys  Pro Lys Asp Pro Val  Ser Gln Val Glu Ser  Ile Lys Gln 
    1445                 1450                 1455             


Asp Lys  Pro Val Ile His Phe  Gly Val Val Ser Glu  Ser Leu Pro 
    1460                 1465                 1470             


Gln Thr  Gly Val Thr Pro Gln  Tyr Arg Gly Tyr Thr  Leu Leu Gly 
    1475                 1480                 1485             


Leu Gly  Leu Val Ile Arg Val  Ile Asn Asp Lys Lys  Asn Arg Met 
    1490                 1495                 1500             


Lys 
    


<210>  53
<211>  2178
<212>  PRT
<213>  Lactobacillus paracasei

<400>  53

Met Asn Arg Val Lys Pro Phe Ser Gln Glu Lys Arg Arg Tyr Lys Met 
1               5                   10                  15      


Tyr Lys Ser Gly Arg His Trp Val Tyr Ser Ala Ile Val Thr Phe Gly 
            20                  25                  30          


Ala Ala Ser Phe Leu Met Met Gln Pro Ala Gln Gly Val Ser Ala Asp 
        35                  40                  45              


Ala Ala Ala Pro Pro Pro Thr Thr Gln Thr Lys Ser Asn Gln Ala Ala 
    50                  55                  60                  


Pro Asp Ala Ala Ser Ala Asp Ser Pro Val Ser Lys Pro Ala Ser Ala 
65                  70                  75                  80  


Thr Thr Gly Gln Val Thr Ser Ser Ala Asp Thr Pro Thr Thr Thr Ala 
                85                  90                  95      


Ala Ser Ala Thr Pro Thr Ala Thr Ala Lys Ser Ala Thr Pro Ala Pro 
            100                 105                 110         


Val Ala Ser Gln Ala Lys Pro Glu Ala Ser Ala Lys Ala Lys Gln Pro 
        115                 120                 125             


Thr Gln Pro Thr Ser Val Thr Pro Ser Thr Pro Thr Thr Thr Asn Thr 
    130                 135                 140                 


Lys Thr Ala Gln Lys Thr Val Ser Gln Pro Ala Gln Lys Ala Pro Ala 
145                 150                 155                 160 


Ala Pro Ala Lys Pro Ala Pro Ile Ala Lys Pro Ala Pro Thr Ser Asn 
                165                 170                 175     


Pro Glu Asn Lys Ala Ser Leu Thr Lys Gly Asn Val Gln Pro Leu Trp 
            180                 185                 190         


Asp Gln Asn Ile Lys Gly Gln Gly Met Val Ala Ala Val Ile Asp Gln 
        195                 200                 205             


Gly Val Glu Pro His Gln Asp Phe Arg Leu Ser Asp Ala Lys Thr Ala 
    210                 215                 220                 


Ala Leu Ser Glu Asp Gln Ile Lys Ala Phe Thr Ala Ser His Gly Tyr 
225                 230                 235                 240 


Gly Asp Tyr Val Asn Glu Lys Ile Pro Phe Phe Tyr Asp Tyr Thr Asn 
                245                 250                 255     


Asn Val Asn Glu Asn Leu Lys Phe Asp Thr Ser Asn His Gly Gln His 
            260                 265                 270         


Leu Ala Gly Ile Ile Ala Ala Asn Gly Gln Pro Ser Asp Ser Lys Lys 
        275                 280                 285             


Tyr Val Thr Gly Ile Ala Pro Glu Ala Gln Leu Leu Ser Met Lys Ile 
    290                 295                 300                 


Leu Gly Lys Ser Ser Ser Asp Ser Leu Asn Asn Ala Ala Arg Ala Ile 
305                 310                 315                 320 


Tyr Asp Ala Val Asp Leu Gly Ala Asn Ala Ile Asn Ile Ser Phe Gly 
                325                 330                 335     


Met Gly Val Asp Ile Asp Asp Pro Thr Ala Glu Gly Gln Ala Ala Ile 
            340                 345                 350         


Lys Phe Ala Thr Asp His Gly Val Phe Val Thr Val Ala Thr Gly Asn 
        355                 360                 365             


Asn Gly His Ala Gly Gly Ile Tyr Asp Lys Ser Ala Ser Asn Gly Ile 
    370                 375                 380                 


Thr Thr Ser Tyr Gln Pro Ala Asn Ala Ser Thr Leu Thr Thr Pro Ser 
385                 390                 395                 400 


Ala Thr Pro Ser Ala Met Ala Val Ala Ala Gly Asn Asp Val Leu Asp 
                405                 410                 415     


Ala Lys Ala Ala Leu Ile Ser Pro Ser Ser Trp Gly Pro Thr Thr Ser 
            420                 425                 430         


Tyr Lys Leu Lys Pro Asp Ile Thr Ala Pro Gly Glu Lys Val Ala Ser 
        435                 440                 445             


Thr Leu Leu Asn Asp Glu Leu Gly Lys Val Ser Gly Thr Ser Gln Ala 
    450                 455                 460                 


Asn Ala Tyr Val Thr Gly Ala Ser Leu Leu Val Met Gln Asn Leu Lys 
465                 470                 475                 480 


Arg Ser Thr Asn Leu Thr Gly Ala Gln Leu Val Lys Ala Val Lys Leu 
                485                 490                 495     


Ala Leu Met Asn Ala Ala Asn Pro Ile Leu Asp Ile Asn Tyr Pro Gly 
            500                 505                 510         


Gln Ile Ile Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Ala 
        515                 520                 525             


Lys Ala Ala Asn Leu Thr Val Ser Ala Glu Gly Thr Asp Asp Ala Gly 
    530                 535                 540                 


Ser Val Ser Leu Gln Gln Phe Thr Gly Ser Lys Ser Phe Val Ile Thr 
545                 550                 555                 560 


Leu Glu Asn Arg Gly Thr Asp Gln Gln Thr Tyr Thr Leu Asp Leu Gly 
                565                 570                 575     


Gln Pro Ala Thr Glu Val Ile Asp Thr Ala Asn Asn Lys Thr Val His 
            580                 585                 590         


Asp Arg Thr Leu Pro Gly Ala Thr Leu Thr Thr Ala Thr Pro Thr Phe 
        595                 600                 605             


Thr Leu Asp Ala Gly Ala Ser Lys Lys Ile Thr Phe Thr Leu Ser Leu 
    610                 615                 620                 


Asp Asp Thr Val Lys Leu Asn Gln Val Val Glu Gly Phe Ile Lys Phe 
625                 630                 635                 640 


Lys Ala Ala Asp Asp Arg Gln Ser Ile Ser Val Pro Tyr Met Gly Tyr 
                645                 650                 655     


Tyr Gly Ser Thr Asn Asp Glu Ala Val Phe Asp Lys Pro Ala Asn Glu 
            660                 665                 670         


Glu Gly Ser Ile Phe Lys Gly Gly Tyr Leu Val Asp Asn Asn His Asn 
        675                 680                 685             


Pro Leu Gly Ile Thr Asp Pro Thr Ser Leu Ser Glu Leu Val Asn Asn 
    690                 695                 700                 


Pro Thr Asn Gly Phe Thr Trp Gln Thr Ile Gly Ala Lys Ile Glu Asn 
705                 710                 715                 720 


Asn Lys Val Ala Phe Ser Pro Asn Gly Asp Gly Ile Ser Asp Thr Ile 
                725                 730                 735     


Thr Pro Tyr Val Phe Thr Lys Gln Asn Leu Lys Gln Val Ile Ala Gln 
            740                 745                 750         


Ile Leu Asp Gln Asp Asn Lys Val Met Arg Val Ile Asp Gln Glu Thr 
        755                 760                 765             


Asp Thr Thr Lys Ser Phe Leu Glu Val Gly Ser Thr Thr Asn Ala Asp 
    770                 775                 780                 


Leu Ala Lys Ser Ile Ser Met Phe Leu Asn Pro Asp Lys Leu Lys Trp 
785                 790                 795                 800 


Asp Gly Gln Val Tyr Asp Gln Thr Thr Gly Gln Met Val Pro Ala Lys 
                805                 810                 815     


Asp Gly Ile Tyr Thr Tyr Arg Leu Ile Gly Met Thr Tyr Thr Pro Gly 
            820                 825                 830         


Glu Asn Asn Met Gln Thr Met Ser Leu Pro Val Ala Val Asp Thr Ile 
        835                 840                 845             


Lys Pro Thr Leu Ser Asn Leu Ala Tyr Ser Asp Gly Lys Leu Thr Ala 
    850                 855                 860                 


Asp Tyr Ser Asp Gln Gly Val Gly Phe Thr Ala Tyr Ser Gln Ala Lys 
865                 870                 875                 880 


Leu Thr Ile Gly Ser Ala Thr Tyr Gly Ile Pro Leu Asn His Asp Asn 
                885                 890                 895     


Lys Ala Thr Ser Gly Thr Ile Asn Tyr Gln Leu Asn Asp Asp Gln Leu 
            900                 905                 910         


Ala Asn Leu Lys Thr Gly Glu Gly Lys Val Thr Leu Thr Ile Thr Asp 
        915                 920                 925             


Ala Ala Gly Asn Ser Asp Gln Gly Ser Ile Lys Ala Val Val Gly Glu 
    930                 935                 940                 


Asn Lys Thr Ile Glu Ser Asn Phe Ile Trp Pro Gln Val Arg Trp Ser 
945                 950                 955                 960 


Met Pro Asp Thr Lys Gly Asn Leu Thr Arg Ser Asp Gly Arg Tyr Gln 
                965                 970                 975     


Ala Leu Thr Lys Asp Ser Thr Phe Thr Ala Gln Ala Met Val Pro Lys 
            980                 985                 990         


Gly Gln Asp Tyr Ile Val Thr Ala  Thr Asp Tyr Val Ser  Asp Arg Gln 
        995                 1000                 1005             


Tyr Ile  Gly Thr Leu Asp Lys  Ala Thr Gly Ile Val  Thr Phe Asn 
    1010                 1015                 1020             


Ile Asp  Ala Thr Gly Gln Pro  Tyr Ala Asn Leu Thr  Ile Ser Ala 
    1025                 1030                 1035             


Phe Ala  Arg Asp Asp Phe Gly  Glu Phe Ile Lys Ser  Pro Lys Thr 
    1040                 1045                 1050             


Glu Asp  Phe Ile Ile Phe Ile  Lys Lys Asn Thr Ala  Ala Tyr Ser 
    1055                 1060                 1065             


Asn Ala  Lys Thr Gln Thr Lys  Pro Phe Ala Asp Glu  Ala Thr Ala 
    1070                 1075                 1080             


Ile Lys  Gly Ala Lys Phe Phe  Ser Gly Ala Ala His  Leu Thr Gly 
    1085                 1090                 1095             


Arg Ser  Pro Leu Thr Ser Thr  Lys Gly Lys Met Ile  Asn Gly Ile 
    1100                 1105                 1110             


Ala Phe  Leu Asp Leu Asn Asn  Asn Lys Arg Thr Leu  Val Gly Ile 
    1115                 1120                 1125             


Asp Ser  Ala Ser Thr Phe Tyr  Asp Ala Lys Leu Lys  Thr Leu Thr 
    1130                 1135                 1140             


Leu Arg  Gly Lys Val Ser Asp  Pro Lys Asn Ser Lys  Leu Arg Ile 
    1145                 1150                 1155             


Phe Val  Thr Pro Arg Gln Asn  Asp Pro Gln Asn Glu  Val Thr Phe 
    1160                 1165                 1170             


Ala Ala  Asp Gly Ser Phe Ser  Met Thr Met Pro Cys  Asn Pro Thr 
    1175                 1180                 1185             


Glu Glu  Arg Asn Ile Gly Tyr  Val Leu Thr Thr Leu  Asp Lys Asp 
    1190                 1195                 1200             


Gly Lys  Glu Lys Thr Asn Gly  Gly Phe Leu Leu Leu  Tyr Thr Asp 
    1205                 1210                 1215             


Thr Thr  Leu Pro Thr Leu Glu  Leu Ser Asp Ala Asp  Ser Met Lys 
    1220                 1225                 1230             


Ile Asp  Asp Asp Gly Thr Tyr  Leu Val Thr Thr Asp  Ala Asp Thr 
    1235                 1240                 1245             


Phe Ser  Ile Lys Gly Ser Val  Thr Asp Asn Ile Gly  Gly Tyr Arg 
    1250                 1255                 1260             


Leu Tyr  Ser Asn Gly Asn Asn  Ile Phe Met Gln Gln  Asn Leu Ala 
    1265                 1270                 1275             


Gly Phe  Asn Ala His Gln Ser  Ser Ala Ala Pro Asn  Gln Leu Thr 
    1280                 1285                 1290             


Asn Gly  Tyr Asn Pro Tyr Gly  Ala Ala Ser Phe Asp  Glu Thr Tyr 
    1295                 1300                 1305             


Gln Leu  Thr Asp Gly Leu Asn  Ile Ile Thr Leu Gln  Ala Val Asp 
    1310                 1315                 1320             


Gln Val  Gly Asn Thr Val Thr  Lys Thr Phe Asn Val  Thr Lys Thr 
    1325                 1330                 1335             


Pro Lys  Leu Leu Lys Glu Glu  Ser Leu Asp Glu Leu  Glu Ile Thr 
    1340                 1345                 1350             


Pro Glu  Gln Gln Asp Gln Thr  Pro Lys Asn Asp Ala  Gly Glu Ala 
    1355                 1360                 1365             


Pro Val  Thr Thr Pro Ala Thr  Glu Glu Thr Leu Val  Thr Pro Ser 
    1370                 1375                 1380             


Thr Glu  Ser Thr Met Val Asn  Pro Glu Asp Ser Lys  Val Glu Thr 
    1385                 1390                 1395             


Ser Asp  Pro Ile Val Glu Thr  Ala Pro Ser Lys Glu  Ala Gln Ser 
    1400                 1405                 1410             


Asp Gly  Asn Gly Ala Thr Glu  Thr Asn Thr Thr Ala  Ser Val Thr 
    1415                 1420                 1425             


Thr Gly  Val Asp Glu Asn Pro  Val Asp Ser Ser Ala  Asn Ala Ala 
    1430                 1435                 1440             


Thr Pro  Met Pro Asn His Val  Lys Asp Ala Asn Thr  Asp Ala Glu 
    1445                 1450                 1455             


Val Thr  Glu Val Thr Asn Thr  Lys Asp Asn Thr Gln  Gly Thr Thr 
    1460                 1465                 1470             


Ala Pro  Thr Ser Thr Asp Pro  Ala Thr Asp Lys Glu  Ser Thr Thr 
    1475                 1480                 1485             


Lys Ser  Glu Ile Asp Pro Ala  Ala Thr Ser Pro Asn  Asp Ser Lys 
    1490                 1495                 1500             


Val Val  Glu Ala Val Thr Lys  Glu Ala Ala Val Asn  Asp Asp Lys 
    1505                 1510                 1515             


Gly Asn  Gln Ala Asp Asp Gly  Glu Pro Thr Val Thr  Asn Leu Ala 
    1520                 1525                 1530             


Thr Ser  Lys Asp Ser Ala Val  Gln Pro Glu Val Asp  Pro Ala Ser 
    1535                 1540                 1545             


Gly Leu  Gln Ser Asp Asp Lys  Val Val Glu Thr Ala  Val Glu Asp 
    1550                 1555                 1560             


Asp Glu  Met Val Glu Lys Glu  Gly His Lys Ser Asp  Asn Ala Lys 
    1565                 1570                 1575             


Pro Ala  Ile Thr Asp Pro Thr  Thr Asp Lys Asp Lys  Ala Val Gln 
    1580                 1585                 1590             


Ser Glu  Val Asn Pro Thr Ala  Ser Ser Gln Gly Ala  Thr Lys Ala 
    1595                 1600                 1605             


Val Glu  Ala Ala Ala Lys Asp  Thr Lys Val Glu Asp  Asp Lys Gly 
    1610                 1615                 1620             


Asn Lys  Thr Ala Ser Val Glu  Thr Gly Val Ala Thr  Pro Ala Met 
    1625                 1630                 1635             


Asp Asn  Asn Ser Ser Val Lys  Ser Ala Val Asp Pro  Thr Ala Thr 
    1640                 1645                 1650             


Ala Pro  Ser Asp Asn Thr Ala  Pro Ala Ile Glu Thr  Ala Ala Glu 
    1655                 1660                 1665             


Asn Phe  Asn Ile Glu Asn Asp  Lys Gly Asn Glu Thr  Asn Ala Val 
    1670                 1675                 1680             


Glu Thr  Val Val Thr Asp Pro  Ala Thr Asn Lys Glu  Gly Thr Val 
    1685                 1690                 1695             


Lys Ser  Glu Ile Glu Pro Val  Ala Thr Thr Pro Ser  Asn Thr Thr 
    1700                 1705                 1710             


Val Thr  Ala Thr Glu Met Thr  Lys Glu Asn Thr Pro  Ala Glu Asp 
    1715                 1720                 1725             


Glu Lys  Asp Asn Gln Val Asn  Ala Val Thr Asp Pro  Lys Thr Thr 
    1730                 1735                 1740             


Lys Asp  Ser Ala Asp Lys Ser  Glu Ile Glu Pro Val  Ala Thr Ala 
    1745                 1750                 1755             


Ala Thr  Asp Lys Asp Arg Thr  Val Lys Ser Asp Pro  Thr Glu Ala 
    1760                 1765                 1770             


Ala Ser  Thr Pro Ser Glu Asp  Ser Ile Arg Lys Thr  Thr Ala Glu 
    1775                 1780                 1785             


Asp Ala  Lys Ala Lys Asp Asp  Arg Glu Ala Ala Ala  Asn Ala Val 
    1790                 1795                 1800             


Ala Ala  Asp Ser Lys Ala Asp  Lys Asn Asn Pro Val  Glu Ser Lys 
    1805                 1810                 1815             


Ile Asp  Ala Thr Ala Ile Thr  Pro Ser Asn Ser Gln  Pro Thr Glu 
    1820                 1825                 1830             


Thr Asp  Thr Glu Asn Ala Ala  Val Glu Asn Gly Lys  Asp Gln Lys 
    1835                 1840                 1845             


Ser Ala  Asp Thr Pro Ser Pro  Val Ile Asp Pro Ala  Val Asp Lys 
    1850                 1855                 1860             


Asp Arg  Ala Val Lys Ser Lys  Val Asn Pro Ala Thr  Thr Ala Pro 
    1865                 1870                 1875             


Asn Asp  Asp Lys Ala Pro Glu  Val Thr Thr Glu Ser  Ser Lys Ile 
    1880                 1885                 1890             


Glu Asn  Val Lys Ser His Gln  Ser Asp Val Val Glu  Thr Phe Gly 
    1895                 1900                 1905             


Ser Asp  Ser Gln Thr Ser Lys  Asp Pro Val Ala Glu  Ser Lys Arg 
    1910                 1915                 1920             


Asn Pro  Thr Ala Thr Ser Ser  Ser Asp Asp Thr Thr  Thr Glu Thr 
    1925                 1930                 1935             


Glu Thr  Leu Ala Thr Gly Gly  Glu Gln Asn Ser Gln  Val Asp Thr 
    1940                 1945                 1950             


Pro Lys  Lys Ala Met Thr Thr  Thr Pro Asn Asp Lys  Asn Val Ser 
    1955                 1960                 1965             


Leu Ala  Thr Val Ala Pro Asp  Lys Thr Lys Gly Asp  Thr Ala Gly 
    1970                 1975                 1980             


Ala Arg  Thr Val Thr Thr Thr  Asp Gly Gln Arg Lys  Pro Thr Lys 
    1985                 1990                 1995             


Thr Glu  Val Gly Ser Ser Asn  Val Ala Ser Asn His  Pro Ser Thr 
    2000                 2005                 2010             


Thr Asp  Ser Ser Thr Glu Thr  Thr Ser Gln Ser Asp  Glu Pro Thr 
    2015                 2020                 2025             


Ser Ser  Ile Glu Thr Thr Glu  Pro Ala Thr Thr Ala  Pro Ser Thr 
    2030                 2035                 2040             


Glu Asp  Lys Pro Val Arg Thr  Thr Ala Asp Gln Lys  Val Thr Asp 
    2045                 2050                 2055             


Gln Lys  Ser Asn Lys Asp Asp  Gln Ala Asn Pro Thr  Ala Ile Lys 
    2060                 2065                 2070             


Lys Lys  Leu Lys Ser Lys Val  Thr Glu Asp Gly Glu  Asn Ile Ser 
    2075                 2080                 2085             


Gln Thr  Asn Gln Lys Asp Pro  Lys Thr Lys Thr Ala  Lys Gly Glu 
    2090                 2095                 2100             


Gln Thr  Thr Ser Pro Leu Asp  Gln Lys Arg Ser Ala  Leu Lys Gln 
    2105                 2110                 2115             


Lys Glu  Ser Lys Glu Ile Ala  Pro Glu Lys Ser Val  His Ala Thr 
    2120                 2125                 2130             


Lys Thr  Ala Ala Lys Thr Leu  Pro Pro Met Gly Met  Gln Asn Ser 
    2135                 2140                 2145             


His Trp  Leu Gln Ala Leu Gly  Ile Ala Leu Leu Gly  Met Ile Leu 
    2150                 2155                 2160             


Ala Leu  Gly Ile Gly Leu Thr  Ser Lys Lys Lys His  Glu Lys Ser 
    2165                 2170                 2175             


<210>  54
<211>  2127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Lactobacillus paracasei subsp. paracasei 8700:2 
       protease

<400>  54

Pro Pro Pro Thr Thr Gln Thr Lys Ser Asn Gln Ala Ala Pro Asp Ala 
1               5                   10                  15      


Ala Ser Ala Asp Ser Pro Val Ser Lys Pro Ala Ser Ala Thr Thr Gly 
            20                  25                  30          


Gln Val Thr Ser Ser Ala Asp Thr Pro Thr Thr Thr Ala Ala Ser Ala 
        35                  40                  45              


Thr Pro Thr Ala Thr Ala Lys Ser Ala Thr Pro Ala Pro Val Ala Ser 
    50                  55                  60                  


Gln Ala Lys Pro Glu Ala Ser Ala Lys Ala Lys Gln Pro Thr Gln Pro 
65                  70                  75                  80  


Thr Ser Val Thr Pro Ser Thr Pro Thr Thr Thr Asn Thr Lys Thr Ala 
                85                  90                  95      


Gln Lys Thr Val Ser Gln Pro Ala Gln Lys Ala Pro Ala Ala Pro Ala 
            100                 105                 110         


Lys Pro Ala Pro Ile Ala Lys Pro Ala Pro Thr Ser Asn Pro Glu Asn 
        115                 120                 125             


Lys Ala Ser Leu Thr Lys Gly Asn Val Gln Pro Leu Trp Asp Gln Asn 
    130                 135                 140                 


Ile Lys Gly Gln Gly Met Val Ala Ala Val Ile Asp Gln Gly Val Glu 
145                 150                 155                 160 


Pro His Gln Asp Phe Arg Leu Ser Asp Ala Lys Thr Ala Ala Leu Ser 
                165                 170                 175     


Glu Asp Gln Ile Lys Ala Phe Thr Ala Ser His Gly Tyr Gly Asp Tyr 
            180                 185                 190         


Val Asn Glu Lys Ile Pro Phe Phe Tyr Asp Tyr Thr Asn Asn Val Asn 
        195                 200                 205             


Glu Asn Leu Lys Phe Asp Thr Ser Asn His Gly Gln His Leu Ala Gly 
    210                 215                 220                 


Ile Ile Ala Ala Asn Gly Gln Pro Ser Asp Ser Lys Lys Tyr Val Thr 
225                 230                 235                 240 


Gly Ile Ala Pro Glu Ala Gln Leu Leu Ser Met Lys Ile Leu Gly Lys 
                245                 250                 255     


Ser Ser Ser Asp Ser Leu Asn Asn Ala Ala Arg Ala Ile Tyr Asp Ala 
            260                 265                 270         


Val Asp Leu Gly Ala Asn Ala Ile Asn Ile Ser Phe Gly Met Gly Val 
        275                 280                 285             


Asp Ile Asp Asp Pro Thr Ala Glu Gly Gln Ala Ala Ile Lys Phe Ala 
    290                 295                 300                 


Thr Asp His Gly Val Phe Val Thr Val Ala Thr Gly Asn Asn Gly His 
305                 310                 315                 320 


Ala Gly Gly Ile Tyr Asp Lys Ser Ala Ser Asn Gly Ile Thr Thr Ser 
                325                 330                 335     


Tyr Gln Pro Ala Asn Ala Ser Thr Leu Thr Thr Pro Ser Ala Thr Pro 
            340                 345                 350         


Ser Ala Met Ala Val Ala Ala Gly Asn Asp Val Leu Asp Ala Lys Ala 
        355                 360                 365             


Ala Leu Ile Ser Pro Ser Ser Trp Gly Pro Thr Thr Ser Tyr Lys Leu 
    370                 375                 380                 


Lys Pro Asp Ile Thr Ala Pro Gly Glu Lys Val Ala Ser Thr Leu Leu 
385                 390                 395                 400 


Asn Asp Glu Leu Gly Lys Val Ser Gly Thr Ser Gln Ala Asn Ala Tyr 
                405                 410                 415     


Val Thr Gly Ala Ser Leu Leu Val Met Gln Asn Leu Lys Arg Ser Thr 
            420                 425                 430         


Asn Leu Thr Gly Ala Gln Leu Val Lys Ala Val Lys Leu Ala Leu Met 
        435                 440                 445             


Asn Ala Ala Asn Pro Ile Leu Asp Ile Asn Tyr Pro Gly Gln Ile Ile 
    450                 455                 460                 


Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Ala Lys Ala Ala 
465                 470                 475                 480 


Asn Leu Thr Val Ser Ala Glu Gly Thr Asp Asp Ala Gly Ser Val Ser 
                485                 490                 495     


Leu Gln Gln Phe Thr Gly Ser Lys Ser Phe Val Ile Thr Leu Glu Asn 
            500                 505                 510         


Arg Gly Thr Asp Gln Gln Thr Tyr Thr Leu Asp Leu Gly Gln Pro Ala 
        515                 520                 525             


Thr Glu Val Ile Asp Thr Ala Asn Asn Lys Thr Val His Asp Arg Thr 
    530                 535                 540                 


Leu Pro Gly Ala Thr Leu Thr Thr Ala Thr Pro Thr Phe Thr Leu Asp 
545                 550                 555                 560 


Ala Gly Ala Ser Lys Lys Ile Thr Phe Thr Leu Ser Leu Asp Asp Thr 
                565                 570                 575     


Val Lys Leu Asn Gln Val Val Glu Gly Phe Ile Lys Phe Lys Ala Ala 
            580                 585                 590         


Asp Asp Arg Gln Ser Ile Ser Val Pro Tyr Met Gly Tyr Tyr Gly Ser 
        595                 600                 605             


Thr Asn Asp Glu Ala Val Phe Asp Lys Pro Ala Asn Glu Glu Gly Ser 
    610                 615                 620                 


Ile Phe Lys Gly Gly Tyr Leu Val Asp Asn Asn His Asn Pro Leu Gly 
625                 630                 635                 640 


Ile Thr Asp Pro Thr Ser Leu Ser Glu Leu Val Asn Asn Pro Thr Asn 
                645                 650                 655     


Gly Phe Thr Trp Gln Thr Ile Gly Ala Lys Ile Glu Asn Asn Lys Val 
            660                 665                 670         


Ala Phe Ser Pro Asn Gly Asp Gly Ile Ser Asp Thr Ile Thr Pro Tyr 
        675                 680                 685             


Val Phe Thr Lys Gln Asn Leu Lys Gln Val Ile Ala Gln Ile Leu Asp 
    690                 695                 700                 


Gln Asp Asn Lys Val Met Arg Val Ile Asp Gln Glu Thr Asp Thr Thr 
705                 710                 715                 720 


Lys Ser Phe Leu Glu Val Gly Ser Thr Thr Asn Ala Asp Leu Ala Lys 
                725                 730                 735     


Ser Ile Ser Met Phe Leu Asn Pro Asp Lys Leu Lys Trp Asp Gly Gln 
            740                 745                 750         


Val Tyr Asp Gln Thr Thr Gly Gln Met Val Pro Ala Lys Asp Gly Ile 
        755                 760                 765             


Tyr Thr Tyr Arg Leu Ile Gly Met Thr Tyr Thr Pro Gly Glu Asn Asn 
    770                 775                 780                 


Met Gln Thr Met Ser Leu Pro Val Ala Val Asp Thr Ile Lys Pro Thr 
785                 790                 795                 800 


Leu Ser Asn Leu Ala Tyr Ser Asp Gly Lys Leu Thr Ala Asp Tyr Ser 
                805                 810                 815     


Asp Gln Gly Val Gly Phe Thr Ala Tyr Ser Gln Ala Lys Leu Thr Ile 
            820                 825                 830         


Gly Ser Ala Thr Tyr Gly Ile Pro Leu Asn His Asp Asn Lys Ala Thr 
        835                 840                 845             


Ser Gly Thr Ile Asn Tyr Gln Leu Asn Asp Asp Gln Leu Ala Asn Leu 
    850                 855                 860                 


Lys Thr Gly Glu Gly Lys Val Thr Leu Thr Ile Thr Asp Ala Ala Gly 
865                 870                 875                 880 


Asn Ser Asp Gln Gly Ser Ile Lys Ala Val Val Gly Glu Asn Lys Thr 
                885                 890                 895     


Ile Glu Ser Asn Phe Ile Trp Pro Gln Val Arg Trp Ser Met Pro Asp 
            900                 905                 910         


Thr Lys Gly Asn Leu Thr Arg Ser Asp Gly Arg Tyr Gln Ala Leu Thr 
        915                 920                 925             


Lys Asp Ser Thr Phe Thr Ala Gln Ala Met Val Pro Lys Gly Gln Asp 
    930                 935                 940                 


Tyr Ile Val Thr Ala Thr Asp Tyr Val Ser Asp Arg Gln Tyr Ile Gly 
945                 950                 955                 960 


Thr Leu Asp Lys Ala Thr Gly Ile Val Thr Phe Asn Ile Asp Ala Thr 
                965                 970                 975     


Gly Gln Pro Tyr Ala Asn Leu Thr Ile Ser Ala Phe Ala Arg Asp Asp 
            980                 985                 990         


Phe Gly Glu Phe Ile Lys Ser Pro  Lys Thr Glu Asp Phe  Ile Ile Phe 
        995                 1000                 1005             


Ile Lys  Lys Asn Thr Ala Ala  Tyr Ser Asn Ala Lys  Thr Gln Thr 
    1010                 1015                 1020             


Lys Pro  Phe Ala Asp Glu Ala  Thr Ala Ile Lys Gly  Ala Lys Phe 
    1025                 1030                 1035             


Phe Ser  Gly Ala Ala His Leu  Thr Gly Arg Ser Pro  Leu Thr Ser 
    1040                 1045                 1050             


Thr Lys  Gly Lys Met Ile Asn  Gly Ile Ala Phe Leu  Asp Leu Asn 
    1055                 1060                 1065             


Asn Asn  Lys Arg Thr Leu Val  Gly Ile Asp Ser Ala  Ser Thr Phe 
    1070                 1075                 1080             


Tyr Asp  Ala Lys Leu Lys Thr  Leu Thr Leu Arg Gly  Lys Val Ser 
    1085                 1090                 1095             


Asp Pro  Lys Asn Ser Lys Leu  Arg Ile Phe Val Thr  Pro Arg Gln 
    1100                 1105                 1110             


Asn Asp  Pro Gln Asn Glu Val  Thr Phe Ala Ala Asp  Gly Ser Phe 
    1115                 1120                 1125             


Ser Met  Thr Met Pro Cys Asn  Pro Thr Glu Glu Arg  Asn Ile Gly 
    1130                 1135                 1140             


Tyr Val  Leu Thr Thr Leu Asp  Lys Asp Gly Lys Glu  Lys Thr Asn 
    1145                 1150                 1155             


Gly Gly  Phe Leu Leu Leu Tyr  Thr Asp Thr Thr Leu  Pro Thr Leu 
    1160                 1165                 1170             


Glu Leu  Ser Asp Ala Asp Ser  Met Lys Ile Asp Asp  Asp Gly Thr 
    1175                 1180                 1185             


Tyr Leu  Val Thr Thr Asp Ala  Asp Thr Phe Ser Ile  Lys Gly Ser 
    1190                 1195                 1200             


Val Thr  Asp Asn Ile Gly Gly  Tyr Arg Leu Tyr Ser  Asn Gly Asn 
    1205                 1210                 1215             


Asn Ile  Phe Met Gln Gln Asn  Leu Ala Gly Phe Asn  Ala His Gln 
    1220                 1225                 1230             


Ser Ser  Ala Ala Pro Asn Gln  Leu Thr Asn Gly Tyr  Asn Pro Tyr 
    1235                 1240                 1245             


Gly Ala  Ala Ser Phe Asp Glu  Thr Tyr Gln Leu Thr  Asp Gly Leu 
    1250                 1255                 1260             


Asn Ile  Ile Thr Leu Gln Ala  Val Asp Gln Val Gly  Asn Thr Val 
    1265                 1270                 1275             


Thr Lys  Thr Phe Asn Val Thr  Lys Thr Pro Lys Leu  Leu Lys Glu 
    1280                 1285                 1290             


Glu Ser  Leu Asp Glu Leu Glu  Ile Thr Pro Glu Gln  Gln Asp Gln 
    1295                 1300                 1305             


Thr Pro  Lys Asn Asp Ala Gly  Glu Ala Pro Val Thr  Thr Pro Ala 
    1310                 1315                 1320             


Thr Glu  Glu Thr Leu Val Thr  Pro Ser Thr Glu Ser  Thr Met Val 
    1325                 1330                 1335             


Asn Pro  Glu Asp Ser Lys Val  Glu Thr Ser Asp Pro  Ile Val Glu 
    1340                 1345                 1350             


Thr Ala  Pro Ser Lys Glu Ala  Gln Ser Asp Gly Asn  Gly Ala Thr 
    1355                 1360                 1365             


Glu Thr  Asn Thr Thr Ala Ser  Val Thr Thr Gly Val  Asp Glu Asn 
    1370                 1375                 1380             


Pro Val  Asp Ser Ser Ala Asn  Ala Ala Thr Pro Met  Pro Asn His 
    1385                 1390                 1395             


Val Lys  Asp Ala Asn Thr Asp  Ala Glu Val Thr Glu  Val Thr Asn 
    1400                 1405                 1410             


Thr Lys  Asp Asn Thr Gln Gly  Thr Thr Ala Pro Thr  Ser Thr Asp 
    1415                 1420                 1425             


Pro Ala  Thr Asp Lys Glu Ser  Thr Thr Lys Ser Glu  Ile Asp Pro 
    1430                 1435                 1440             


Ala Ala  Thr Ser Pro Asn Asp  Ser Lys Val Val Glu  Ala Val Thr 
    1445                 1450                 1455             


Lys Glu  Ala Ala Val Asn Asp  Asp Lys Gly Asn Gln  Ala Asp Asp 
    1460                 1465                 1470             


Gly Glu  Pro Thr Val Thr Asn  Leu Ala Thr Ser Lys  Asp Ser Ala 
    1475                 1480                 1485             


Val Gln  Pro Glu Val Asp Pro  Ala Ser Gly Leu Gln  Ser Asp Asp 
    1490                 1495                 1500             


Lys Val  Val Glu Thr Ala Val  Glu Asp Asp Glu Met  Val Glu Lys 
    1505                 1510                 1515             


Glu Gly  His Lys Ser Asp Asn  Ala Lys Pro Ala Ile  Thr Asp Pro 
    1520                 1525                 1530             


Thr Thr  Asp Lys Asp Lys Ala  Val Gln Ser Glu Val  Asn Pro Thr 
    1535                 1540                 1545             


Ala Ser  Ser Gln Gly Ala Thr  Lys Ala Val Glu Ala  Ala Ala Lys 
    1550                 1555                 1560             


Asp Thr  Lys Val Glu Asp Asp  Lys Gly Asn Lys Thr  Ala Ser Val 
    1565                 1570                 1575             


Glu Thr  Gly Val Ala Thr Pro  Ala Met Asp Asn Asn  Ser Ser Val 
    1580                 1585                 1590             


Lys Ser  Ala Val Asp Pro Thr  Ala Thr Ala Pro Ser  Asp Asn Thr 
    1595                 1600                 1605             


Ala Pro  Ala Ile Glu Thr Ala  Ala Glu Asn Phe Asn  Ile Glu Asn 
    1610                 1615                 1620             


Asp Lys  Gly Asn Glu Thr Asn  Ala Val Glu Thr Val  Val Thr Asp 
    1625                 1630                 1635             


Pro Ala  Thr Asn Lys Glu Gly  Thr Val Lys Ser Glu  Ile Glu Pro 
    1640                 1645                 1650             


Val Ala  Thr Thr Pro Ser Asn  Thr Thr Val Thr Ala  Thr Glu Met 
    1655                 1660                 1665             


Thr Lys  Glu Asn Thr Pro Ala  Glu Asp Glu Lys Asp  Asn Gln Val 
    1670                 1675                 1680             


Asn Ala  Val Thr Asp Pro Lys  Thr Thr Lys Asp Ser  Ala Asp Lys 
    1685                 1690                 1695             


Ser Glu  Ile Glu Pro Val Ala  Thr Ala Ala Thr Asp  Lys Asp Arg 
    1700                 1705                 1710             


Thr Val  Lys Ser Asp Pro Thr  Glu Ala Ala Ser Thr  Pro Ser Glu 
    1715                 1720                 1725             


Asp Ser  Ile Arg Lys Thr Thr  Ala Glu Asp Ala Lys  Ala Lys Asp 
    1730                 1735                 1740             


Asp Arg  Glu Ala Ala Ala Asn  Ala Val Ala Ala Asp  Ser Lys Ala 
    1745                 1750                 1755             


Asp Lys  Asn Asn Pro Val Glu  Ser Lys Ile Asp Ala  Thr Ala Ile 
    1760                 1765                 1770             


Thr Pro  Ser Asn Ser Gln Pro  Thr Glu Thr Asp Thr  Glu Asn Ala 
    1775                 1780                 1785             


Ala Val  Glu Asn Gly Lys Asp  Gln Lys Ser Ala Asp  Thr Pro Ser 
    1790                 1795                 1800             


Pro Val  Ile Asp Pro Ala Val  Asp Lys Asp Arg Ala  Val Lys Ser 
    1805                 1810                 1815             


Lys Val  Asn Pro Ala Thr Thr  Ala Pro Asn Asp Asp  Lys Ala Pro 
    1820                 1825                 1830             


Glu Val  Thr Thr Glu Ser Ser  Lys Ile Glu Asn Val  Lys Ser His 
    1835                 1840                 1845             


Gln Ser  Asp Val Val Glu Thr  Phe Gly Ser Asp Ser  Gln Thr Ser 
    1850                 1855                 1860             


Lys Asp  Pro Val Ala Glu Ser  Lys Arg Asn Pro Thr  Ala Thr Ser 
    1865                 1870                 1875             


Ser Ser  Asp Asp Thr Thr Thr  Glu Thr Glu Thr Leu  Ala Thr Gly 
    1880                 1885                 1890             


Gly Glu  Gln Asn Ser Gln Val  Asp Thr Pro Lys Lys  Ala Met Thr 
    1895                 1900                 1905             


Thr Thr  Pro Asn Asp Lys Asn  Val Ser Leu Ala Thr  Val Ala Pro 
    1910                 1915                 1920             


Asp Lys  Thr Lys Gly Asp Thr  Ala Gly Ala Arg Thr  Val Thr Thr 
    1925                 1930                 1935             


Thr Asp  Gly Gln Arg Lys Pro  Thr Lys Thr Glu Val  Gly Ser Ser 
    1940                 1945                 1950             


Asn Val  Ala Ser Asn His Pro  Ser Thr Thr Asp Ser  Ser Thr Glu 
    1955                 1960                 1965             


Thr Thr  Ser Gln Ser Asp Glu  Pro Thr Ser Ser Ile  Glu Thr Thr 
    1970                 1975                 1980             


Glu Pro  Ala Thr Thr Ala Pro  Ser Thr Glu Asp Lys  Pro Val Arg 
    1985                 1990                 1995             


Thr Thr  Ala Asp Gln Lys Val  Thr Asp Gln Lys Ser  Asn Lys Asp 
    2000                 2005                 2010             


Asp Gln  Ala Asn Pro Thr Ala  Ile Lys Lys Lys Leu  Lys Ser Lys 
    2015                 2020                 2025             


Val Thr  Glu Asp Gly Glu Asn  Ile Ser Gln Thr Asn  Gln Lys Asp 
    2030                 2035                 2040             


Pro Lys  Thr Lys Thr Ala Lys  Gly Glu Gln Thr Thr  Ser Pro Leu 
    2045                 2050                 2055             


Asp Gln  Lys Arg Ser Ala Leu  Lys Gln Lys Glu Ser  Lys Glu Ile 
    2060                 2065                 2070             


Ala Pro  Glu Lys Ser Val His  Ala Thr Lys Thr Ala  Ala Lys Thr 
    2075                 2080                 2085             


Leu Pro  Pro Met Gly Met Gln  Asn Ser His Trp Leu  Gln Ala Leu 
    2090                 2095                 2100             


Gly Ile  Ala Leu Leu Gly Met  Ile Leu Ala Leu Gly  Ile Gly Leu 
    2105                 2110                 2115             


Thr Ser  Lys Lys Lys His Glu  Lys Ser 
    2120                 2125         


<210>  55
<211>  2239
<212>  PRT
<213>  Lactobacillus sp. HMSC25A02

<400>  55

Met Asn Arg Val Lys Pro Phe Ser Gln Glu Lys Arg Arg Tyr Lys Met 
1               5                   10                  15      


Tyr Lys Ser Gly Arg His Trp Val Tyr Ser Ala Ile Val Thr Phe Gly 
            20                  25                  30          


Ala Ala Ser Phe Leu Met Met Gln Pro Ala Gln Gly Val Ser Ala Asp 
        35                  40                  45              


Ala Thr Thr Pro Pro Thr Thr Thr Gln Thr Lys Ser Asn Gln Ala Ala 
    50                  55                  60                  


Pro Asp Ala Ala Ser Ala Asp Leu Pro Val Ser Lys Pro Ala Ser Thr 
65                  70                  75                  80  


Thr Thr Gly Gln Val Thr Ser Ser Ala Asn Thr Pro Thr Thr Thr Ala 
                85                  90                  95      


Ala Ser Ala Thr Pro Thr Ala Thr Ala Lys Pro Ala Thr Pro Ala Pro 
            100                 105                 110         


Val Ser Ser Gln Ala Lys Pro Glu Ala Ser Ala Lys Ala Lys Gln Pro 
        115                 120                 125             


Thr Gln Pro Thr Ser Val Thr Pro Ser Thr Pro Thr Thr Thr Asn Thr 
    130                 135                 140                 


Lys Thr Ala Gln Lys Thr Val Ser Gln Pro Ala Gln Lys Ala Pro Ala 
145                 150                 155                 160 


Ala Pro Ala Lys Pro Ala Pro Ile Ala Lys Pro Ala Pro Thr Phe Asn 
                165                 170                 175     


Pro Glu Asn Lys Ala Ser Leu Thr Lys Gly Asn Val Gln Pro Leu Trp 
            180                 185                 190         


Asp Gln Asn Ile Lys Gly Gln Gly Met Val Ala Ala Val Ile Asp Gln 
        195                 200                 205             


Gly Val Glu Pro His Gln Asp Phe Arg Leu Ser Asp Ala Lys Thr Ala 
    210                 215                 220                 


Ala Leu Ser Glu Asp Gln Ile Lys Ala Phe Thr Ala Ser His Gly Tyr 
225                 230                 235                 240 


Gly Asp Tyr Val Asn Glu Lys Ile Pro Phe Phe Tyr Asp Tyr Thr Asn 
                245                 250                 255     


Asn Val Asn Glu Asn Leu Lys Phe Asp Thr Ser Asn His Gly Gln His 
            260                 265                 270         


Leu Ala Gly Ile Ile Ala Ala Asn Gly Gln Pro Ser Asp Ser Lys Lys 
        275                 280                 285             


Phe Val Thr Gly Ile Ala Pro Glu Ala Gln Leu Leu Ser Met Lys Ile 
    290                 295                 300                 


Leu Gly Lys Ser Ser Ser Asp Ser Leu Asn Asn Ala Ala Arg Ala Ile 
305                 310                 315                 320 


Tyr Asp Ala Val Asp Leu Gly Ala Asn Ala Ile Asn Ile Ser Phe Gly 
                325                 330                 335     


Met Gly Val Asp Ile Asp Asp Pro Thr Ala Glu Gly Gln Ala Ala Ile 
            340                 345                 350         


Lys Phe Ala Thr Asp His Gly Val Phe Val Thr Val Ala Thr Gly Asn 
        355                 360                 365             


Asn Gly His Ala Gly Gly Ile Tyr Asp Lys Ser Ala Ser Asn Gly Ile 
    370                 375                 380                 


Thr Thr Ser Tyr Gln Pro Ala Asn Ala Ser Thr Leu Thr Thr Pro Ser 
385                 390                 395                 400 


Ala Thr Pro Ser Ala Met Ala Val Ala Ala Gly Asn Asp Val Leu Asp 
                405                 410                 415     


Ala Lys Ala Ala Leu Ile Ser Ala Ser Ser Trp Gly Pro Thr Ala Ser 
            420                 425                 430         


Tyr Lys Leu Lys Pro Asp Ile Thr Ala Pro Gly Glu Lys Val Ala Ser 
        435                 440                 445             


Thr Leu Leu Asn Asp Gly Leu Gly Lys Val Ser Gly Thr Ser Gln Ala 
    450                 455                 460                 


Asn Ala Tyr Val Thr Gly Ala Ser Leu Leu Val Met Gln Asn Leu Lys 
465                 470                 475                 480 


Arg Ser Thr Asn Leu Thr Gly Ala Gln Leu Val Lys Ala Val Lys Leu 
                485                 490                 495     


Ala Leu Met Asn Ala Ala Asn Pro Ile Leu Asp Ile Asn Tyr Pro Gly 
            500                 505                 510         


Gln Ile Ile Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Ala 
        515                 520                 525             


Lys Ala Ala Asn Leu Thr Val Ser Ala Glu Gly Thr Asp Asp Ala Gly 
    530                 535                 540                 


Ser Val Ser Leu Gln Gln Phe Thr Gly Ser Lys Ser Phe Val Ile Thr 
545                 550                 555                 560 


Leu Glu Asn Arg Gly Thr Asp Gln Gln Thr Tyr Thr Leu Asp Leu Gly 
                565                 570                 575     


Gln Pro Ala Thr Glu Val Ile Asp Thr Ala Asn Asn Lys Thr Val His 
            580                 585                 590         


Asp Arg Thr Leu Pro Gly Ala Thr Leu Thr Thr Ala Thr Pro Thr Phe 
        595                 600                 605             


Thr Leu Asp Ala Gly Ala Phe Lys Lys Ile Thr Phe Thr Leu Ser Leu 
    610                 615                 620                 


Asp Asp Thr Val Lys Leu Asn Gln Val Val Glu Gly Phe Ile Lys Phe 
625                 630                 635                 640 


Lys Ala Ala Asp Asp Arg Gln Ser Ile Ser Val Pro Tyr Met Gly Tyr 
                645                 650                 655     


Tyr Gly Ser Thr Asn Asp Glu Ala Val Phe Asp Lys Pro Ala Asn Glu 
            660                 665                 670         


Glu Gly Ser Ile Phe Lys Gly Gly Tyr Leu Val Asp Asn Asn His Asn 
        675                 680                 685             


Pro Leu Gly Ile Thr Asp Pro Thr Ser Leu Ser Glu Leu Val Asn Asn 
    690                 695                 700                 


Pro Thr Asn Gly Phe Thr Trp Gln Thr Ile Gly Ala Lys Val Gln Asn 
705                 710                 715                 720 


Asn Lys Val Ala Phe Ser Pro Asn Gly Asp Gly Ile Ser Asp Thr Ile 
                725                 730                 735     


Thr Pro Tyr Val Phe Thr Lys Gln Asn Leu Lys Gln Val Ile Ala Gln 
            740                 745                 750         


Ile Leu Asp Gln Asp Asp Lys Val Met Arg Val Ile Asp Gln Glu Thr 
        755                 760                 765             


Asp Thr Thr Lys Ser Phe Leu Glu Val Gly Ser Thr Thr Asn Ala Asp 
    770                 775                 780                 


Leu Ala Lys Ser Ile Ser Met Phe Leu Asn Pro Asp Lys Leu Lys Trp 
785                 790                 795                 800 


Asp Gly Gln Val Tyr Asp Gln Thr Thr Gly Gln Met Val Pro Ala Lys 
                805                 810                 815     


Asp Gly Ile Tyr Thr Tyr Arg Leu Ile Gly Met Thr Tyr Thr Pro Gly 
            820                 825                 830         


Glu Asn Asn Met Gln Thr Met Ser Leu Pro Val Ala Val Asp Thr Ile 
        835                 840                 845             


Lys Pro Thr Leu Ser Asn Leu Ala Tyr Ser Asp Gly Lys Leu Thr Ala 
    850                 855                 860                 


Asp Tyr Ser Asp Gln Gly Val Gly Phe Thr Ala Tyr Ser Gln Ala Lys 
865                 870                 875                 880 


Leu Thr Ile Gly Ser Ala Thr Tyr Gly Ile Pro Leu Asn His Asp Asn 
                885                 890                 895     


Lys Ala Thr Thr Gly Thr Ile Asn Tyr Gln Leu Asn Asp Asp Gln Leu 
            900                 905                 910         


Ala Asn Leu Lys Thr Gly Glu Gly Lys Val Thr Leu Thr Ile Thr Asp 
        915                 920                 925             


Ala Ala Gly Asn Ser Asp Gln Gly Ser Ile Lys Ala Val Val Gly Glu 
    930                 935                 940                 


Asn Lys Thr Ile Glu Ser Asn Phe Ile Trp Pro Gln Val Arg Trp Ser 
945                 950                 955                 960 


Met Pro Asp Thr Lys Gly Asn Leu Thr Arg Ser Asp Gly Arg Tyr Gln 
                965                 970                 975     


Ala Leu Thr Lys Asp Ser Thr Phe Thr Ala Gln Ala Met Val Pro Lys 
            980                 985                 990         


Gly Gln Asp Tyr Ile Val Thr Ala  Thr Asp Tyr Val Ser  Asp Arg Gln 
        995                 1000                 1005             


Tyr Ile  Gly Thr Leu Asp Lys  Ala Thr Gly Ile Val  Thr Phe Asn 
    1010                 1015                 1020             


Ile Asp  Ala Thr Gly Gln Pro  Tyr Ala Asn Leu Thr  Ile Ser Ala 
    1025                 1030                 1035             


Ile Ala  Arg Asp Ala Phe Gly  Glu Phe Ile Lys Ser  Pro Lys Thr 
    1040                 1045                 1050             


Glu Asp  Phe Ile Ile Phe Ile  Lys Lys Asn Ala Ala  Ala Tyr Ser 
    1055                 1060                 1065             


Asn Ala  Lys Thr Gln Thr Lys  Pro Phe Ala Asp Glu  Ala Thr Ala 
    1070                 1075                 1080             


Ile Lys  Gly Ala Lys Phe Phe  Ser Gly Ala Ala His  Leu Thr Gly 
    1085                 1090                 1095             


Arg Ser  Pro Leu Thr Ser Thr  Lys Gly Lys Met Ile  Asn Gly Ile 
    1100                 1105                 1110             


Ala Phe  Leu Asp Leu Asn Asn  Asn Lys Arg Thr Leu  Val Gly Ile 
    1115                 1120                 1125             


Asp Ser  Ala Ser Thr Phe Tyr  Asp Ala Lys Leu Lys  Thr Leu Thr 
    1130                 1135                 1140             


Leu Arg  Gly Lys Val Ser Asp  Pro Lys Asn Ser Lys  Leu Arg Ile 
    1145                 1150                 1155             


Phe Val  Thr Pro Arg Gln Asn  Asp Pro Gln Asn Glu  Val Thr Phe 
    1160                 1165                 1170             


Ala Ala  Asp Gly Ser Phe Ser  Met Thr Met Pro Cys  Asn Pro Thr 
    1175                 1180                 1185             


Glu Glu  Arg Asn Ile Gly Tyr  Val Leu Thr Thr Leu  Asp Lys Asp 
    1190                 1195                 1200             


Gly Lys  Glu Lys Thr Asn Gly  Gly Phe Leu Leu Leu  Tyr Met Asp 
    1205                 1210                 1215             


Thr Thr  Leu Pro Thr Leu Glu  Leu Ser Asp Ala Asp  Ser Met Lys 
    1220                 1225                 1230             


Ile Asp  Asp Asp Gly Thr Tyr  Leu Val Thr Thr Asp  Ala Asp Thr 
    1235                 1240                 1245             


Phe Ser  Ile Lys Gly Ser Val  Thr Asp Asn Ile Gly  Gly Tyr Arg 
    1250                 1255                 1260             


Leu Tyr  Ser Asn Gly Asn Asn  Ile Phe Thr Gln Gln  Asn Leu Ala 
    1265                 1270                 1275             


Gly Phe  Asn Ala His Gln Ser  Ser Ala Ala Pro Asn  Gln Leu Thr 
    1280                 1285                 1290             


Asn Gly  Tyr Asn Pro Tyr Gly  Ala Ala Ser Phe Asp  Glu Thr Tyr 
    1295                 1300                 1305             


Gln Leu  Thr Asp Gly Leu Asn  Ile Ile Thr Leu Gln  Ala Val Asp 
    1310                 1315                 1320             


Gln Val  Gly Asn Thr Val Thr  Lys Thr Phe Asn Val  Thr Lys Thr 
    1325                 1330                 1335             


Pro Lys  Leu Leu Lys Glu Glu  Ser Leu Asp Glu Leu  Glu Ile Thr 
    1340                 1345                 1350             


Pro Glu  Gln Glu Asp Gln Thr  Pro Lys Asn Asp Ala  Gly Glu Ala 
    1355                 1360                 1365             


Pro Val  Thr Thr Ser Ser Ser  Asp Glu Lys Ala Glu  Val Thr Pro 
    1370                 1375                 1380             


Ser Thr  Glu Pro Thr Met Val  Asn Pro Glu Asp Ser  Lys Val Glu 
    1385                 1390                 1395             


Thr Ser  Asn Pro Val Val Glu  Ile Asp Thr Ser Lys  Glu Ala Gln 
    1400                 1405                 1410             


Ser Asp  Gly Asn Asp Asp Thr  Ala Thr Asn Thr Pro  Ala Ser Val 
    1415                 1420                 1425             


Thr Thr  Ala Val Asp Glu Asn  Pro Val Asp Asn Ser  Pro Asn Ala 
    1430                 1435                 1440             


Thr Thr  Thr Met Pro Asn His  Ala Lys Gly Val Asp  Ser Asp Ala 
    1445                 1450                 1455             


Glu Ala  Thr Glu Ala Thr Asn  Thr Lys Asp Asn Thr  Pro Gly Thr 
    1460                 1465                 1470             


Thr Ala  Pro Thr Asp Thr Asp  Pro Thr Met Asp Lys  Glu Ser Pro 
    1475                 1480                 1485             


Thr Lys  Ser Glu Val Asp Pro  Thr Ala Thr Ser Leu  Pro Asp Ser 
    1490                 1495                 1500             


Gln Val  Val Glu Thr Ala Thr  Glu Thr Thr Val Asn  Glu Asp Lys 
    1505                 1510                 1515             


Gly Asn  Lys Thr Asp Asp Asp  Glu Pro Thr Ala Thr  Asn Leu Thr 
    1520                 1525                 1530             


Thr Ser  Lys Asp Ser Ala Ile  Gln Pro Lys Ser Asp  Pro Ala Ala 
    1535                 1540                 1545             


Ser Leu  Gln Ser Asn Asp Lys  Ala Val Glu Ala Ala  Ile Glu Asn 
    1550                 1555                 1560             


Asp Lys  Ile Ala Glu Lys Glu  Gly His Gln Ser Ala  Asn Thr Gln 
    1565                 1570                 1575             


Pro Ala  Ile Thr Asp Val Thr  Thr Asp Lys Asp Ser  Ala Val Lys 
    1580                 1585                 1590             


Pro Glu  Ile Asp Pro Ala Ala  Ser Ser Gln Ser Asn  Asp Lys Ala 
    1595                 1600                 1605             


Val Glu  Ala Ala Met Glu Asp  Ser Lys Ala Glu Asn  Asp Lys Gly 
    1610                 1615                 1620             


Ser Lys  Ser Asp Ser Ala Glu  Thr Asn Ile Ala Pro  Thr Met Ala 
    1625                 1630                 1635             


Lys Asn  Ser Gly Val Lys Ser  Glu Ile Asp Leu Thr  Ala Ile Ala 
    1640                 1645                 1650             


Pro Arg  Asp Asn Thr Ala Thr  Ser Ser Gly Thr Ala  Lys Glu Asn 
    1655                 1660                 1665             


Ala Asp  Val Lys Asp Asp Lys  Gly Asn Lys Thr Asp  Thr Val Glu 
    1670                 1675                 1680             


Ser Ala  Val Thr Asp Thr Glu  Asp Asp Asn Glu Gly  Thr Val Lys 
    1685                 1690                 1695             


Ser Glu  Ile Glu Ser Val Ala  Thr Thr Pro Ser Ser  Asn Thr Ala 
    1700                 1705                 1710             


Thr Ala  Thr Glu Ile Thr Lys  Glu Asn Thr Pro Thr  Glu Asp Glu 
    1715                 1720                 1725             


Lys Asp  Asn Gln Val Asn Val  Val Glu Thr Thr Asp  Thr His Pro 
    1730                 1735                 1740             


Lys Pro  Ile Lys Asp Arg Ala  Thr Lys Ser Glu Ile  Glu Ser Glu 
    1745                 1750                 1755             


Ala Thr  Ala Pro Ser Lys Thr  Glu Val Gly Glu Thr  Val Ala Glu 
    1760                 1765                 1770             


Asp Ala  Lys Gly Glu His Asp  Lys Ser Asn Lys Ser  Asp Asp Val 
    1775                 1780                 1785             


Glu Pro  Thr Val Ser Asp Arg  Lys Thr Asp Glu Asp  Arg Ala Ile 
    1790                 1795                 1800             


Lys Ser  Glu Ser Asn Ala Ser  Ala Ile Thr Pro Asn  Glu Asp Asn 
    1805                 1810                 1815             


Ile Asp  Glu Thr Thr Val Glu  Glu Ala Lys Ala Glu  Asp Asn Arg 
    1820                 1825                 1830             


Glu Ala  Ala Ala Gly Thr Ile  Ala Thr Val Ala Ala  Asp Pro Lys 
    1835                 1840                 1845             


Ala Ser  Glu Asp Asn Ser Val  Lys Ser Glu Met Asp  Ala Thr Thr 
    1850                 1855                 1860             


Ile Ala  Pro Ile Asp Asn Lys  Ala Ile Glu Thr Val  Thr Glu Thr 
    1865                 1870                 1875             


Thr Gly  Val Glu Lys Val Glu  Ser His Lys Ser Thr  Asp Thr Glu 
    1880                 1885                 1890             


Ser Pro  Val Thr Asp Pro Ala  Ile Asp Lys Asp Arg  Ala Val Asn 
    1895                 1900                 1905             


Ser Asp  Ile Thr Pro Ala Thr  Ala Ser Pro Thr Ala  Asp Lys Ala 
    1910                 1915                 1920             


Pro Glu  Ala Thr Thr Glu Ser  Val Asp Val Glu Asn  Thr Glu Ser 
    1925                 1930                 1935             


His His  Pro Asp Ile Gly Glu  Thr Ser Val Ser Asp  Ser Gln Ala 
    1940                 1945                 1950             


Gly Lys  Asp Ser Ala Thr Glu  Ser Lys Ile Asp Pro  Lys Ala Thr 
    1955                 1960                 1965             


Pro Ser  Ser Asp Asn Thr Thr  Thr Gly Ser Thr Val  Glu Ile Leu 
    1970                 1975                 1980             


Thr Thr  Gly Ser Glu Gln Asn  Ser Gln Ile Asp Thr  Ser Lys Thr 
    1985                 1990                 1995             


Thr Val  Thr Pro Ala Thr Asp  Asp Lys Lys Val Ser  Ser Glu Thr 
    2000                 2005                 2010             


Ile Ala  Pro Ala Lys Thr Ser  Asp Asp Thr Ala Glu  Phe Gly Thr 
    2015                 2020                 2025             


Ala Thr  Thr Thr Ser Gly Gln  Asn Thr Leu Thr Lys  Thr Glu Val 
    2030                 2035                 2040             


Glu Ser  Ser Asn His Ala Thr  Asn His Pro Asp Thr  Thr Asp Ser 
    2045                 2050                 2055             


Ser Thr  Asp Ala Thr Ser Gln  Pro Asp Glu Pro Thr  Ile Ser Ile 
    2060                 2065                 2070             


Glu Val  Thr Lys Pro Val Pro  Thr Thr Pro Ser Thr  Glu Asp Asn 
    2075                 2080                 2085             


Pro Val  Gln Pro Asn Val Asp  Gln Lys Val Ser Asp  Gln Lys Ser 
    2090                 2095                 2100             


Asp Lys  Asp Asn Gln Asp Asn  Pro Thr Ala Ile Glu  Lys Asn Pro 
    2105                 2110                 2115             


Lys Ser  Lys Val Thr Asp Asp  Glu Glu Thr Ile Ser  Lys Thr Arg 
    2120                 2125                 2130             


Gln Lys  Asp Pro Lys Ser Asn  Ile Val Glu Lys Glu  Asp Asp Thr 
    2135                 2140                 2145             


Ile Leu  Val Val Gln Lys Gly  Leu Lys Ala Lys Thr  Val Lys Asp 
    2150                 2155                 2160             


Ala Glu  Pro Thr Ser Ser Leu  Asp Gln Lys Thr Ser  Ala Leu Lys 
    2165                 2170                 2175             


Gln Lys  Glu Ser Lys Glu Lys  Ala Pro Ala Lys Ser  Val His Pro 
    2180                 2185                 2190             


Thr Lys  Ala Ala Ala Lys Thr  Leu Pro Pro Met Gly  Met Gln Asn 
    2195                 2200                 2205             


Ser His  Trp Leu Gln Ala Leu  Gly Ile Ala Leu Leu  Gly Met Val 
    2210                 2215                 2220             


Phe Ala  Leu Ser Ile Gly Leu  Thr Ser Lys Lys Lys  His Glu Lys 
    2225                 2230                 2235             


Asn 
    


<210>  56
<211>  2188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Lactobacillus sp. HMSC25A02 protease

<400>  56

Pro Pro Thr Thr Thr Gln Thr Lys Ser Asn Gln Ala Ala Pro Asp Ala 
1               5                   10                  15      


Ala Ser Ala Asp Leu Pro Val Ser Lys Pro Ala Ser Thr Thr Thr Gly 
            20                  25                  30          


Gln Val Thr Ser Ser Ala Asn Thr Pro Thr Thr Thr Ala Ala Ser Ala 
        35                  40                  45              


Thr Pro Thr Ala Thr Ala Lys Pro Ala Thr Pro Ala Pro Val Ser Ser 
    50                  55                  60                  


Gln Ala Lys Pro Glu Ala Ser Ala Lys Ala Lys Gln Pro Thr Gln Pro 
65                  70                  75                  80  


Thr Ser Val Thr Pro Ser Thr Pro Thr Thr Thr Asn Thr Lys Thr Ala 
                85                  90                  95      


Gln Lys Thr Val Ser Gln Pro Ala Gln Lys Ala Pro Ala Ala Pro Ala 
            100                 105                 110         


Lys Pro Ala Pro Ile Ala Lys Pro Ala Pro Thr Phe Asn Pro Glu Asn 
        115                 120                 125             


Lys Ala Ser Leu Thr Lys Gly Asn Val Gln Pro Leu Trp Asp Gln Asn 
    130                 135                 140                 


Ile Lys Gly Gln Gly Met Val Ala Ala Val Ile Asp Gln Gly Val Glu 
145                 150                 155                 160 


Pro His Gln Asp Phe Arg Leu Ser Asp Ala Lys Thr Ala Ala Leu Ser 
                165                 170                 175     


Glu Asp Gln Ile Lys Ala Phe Thr Ala Ser His Gly Tyr Gly Asp Tyr 
            180                 185                 190         


Val Asn Glu Lys Ile Pro Phe Phe Tyr Asp Tyr Thr Asn Asn Val Asn 
        195                 200                 205             


Glu Asn Leu Lys Phe Asp Thr Ser Asn His Gly Gln His Leu Ala Gly 
    210                 215                 220                 


Ile Ile Ala Ala Asn Gly Gln Pro Ser Asp Ser Lys Lys Phe Val Thr 
225                 230                 235                 240 


Gly Ile Ala Pro Glu Ala Gln Leu Leu Ser Met Lys Ile Leu Gly Lys 
                245                 250                 255     


Ser Ser Ser Asp Ser Leu Asn Asn Ala Ala Arg Ala Ile Tyr Asp Ala 
            260                 265                 270         


Val Asp Leu Gly Ala Asn Ala Ile Asn Ile Ser Phe Gly Met Gly Val 
        275                 280                 285             


Asp Ile Asp Asp Pro Thr Ala Glu Gly Gln Ala Ala Ile Lys Phe Ala 
    290                 295                 300                 


Thr Asp His Gly Val Phe Val Thr Val Ala Thr Gly Asn Asn Gly His 
305                 310                 315                 320 


Ala Gly Gly Ile Tyr Asp Lys Ser Ala Ser Asn Gly Ile Thr Thr Ser 
                325                 330                 335     


Tyr Gln Pro Ala Asn Ala Ser Thr Leu Thr Thr Pro Ser Ala Thr Pro 
            340                 345                 350         


Ser Ala Met Ala Val Ala Ala Gly Asn Asp Val Leu Asp Ala Lys Ala 
        355                 360                 365             


Ala Leu Ile Ser Ala Ser Ser Trp Gly Pro Thr Ala Ser Tyr Lys Leu 
    370                 375                 380                 


Lys Pro Asp Ile Thr Ala Pro Gly Glu Lys Val Ala Ser Thr Leu Leu 
385                 390                 395                 400 


Asn Asp Gly Leu Gly Lys Val Ser Gly Thr Ser Gln Ala Asn Ala Tyr 
                405                 410                 415     


Val Thr Gly Ala Ser Leu Leu Val Met Gln Asn Leu Lys Arg Ser Thr 
            420                 425                 430         


Asn Leu Thr Gly Ala Gln Leu Val Lys Ala Val Lys Leu Ala Leu Met 
        435                 440                 445             


Asn Ala Ala Asn Pro Ile Leu Asp Ile Asn Tyr Pro Gly Gln Ile Ile 
    450                 455                 460                 


Ser Pro Arg Arg Gln Gly Ala Gly Gln Ile Asp Val Ala Lys Ala Ala 
465                 470                 475                 480 


Asn Leu Thr Val Ser Ala Glu Gly Thr Asp Asp Ala Gly Ser Val Ser 
                485                 490                 495     


Leu Gln Gln Phe Thr Gly Ser Lys Ser Phe Val Ile Thr Leu Glu Asn 
            500                 505                 510         


Arg Gly Thr Asp Gln Gln Thr Tyr Thr Leu Asp Leu Gly Gln Pro Ala 
        515                 520                 525             


Thr Glu Val Ile Asp Thr Ala Asn Asn Lys Thr Val His Asp Arg Thr 
    530                 535                 540                 


Leu Pro Gly Ala Thr Leu Thr Thr Ala Thr Pro Thr Phe Thr Leu Asp 
545                 550                 555                 560 


Ala Gly Ala Phe Lys Lys Ile Thr Phe Thr Leu Ser Leu Asp Asp Thr 
                565                 570                 575     


Val Lys Leu Asn Gln Val Val Glu Gly Phe Ile Lys Phe Lys Ala Ala 
            580                 585                 590         


Asp Asp Arg Gln Ser Ile Ser Val Pro Tyr Met Gly Tyr Tyr Gly Ser 
        595                 600                 605             


Thr Asn Asp Glu Ala Val Phe Asp Lys Pro Ala Asn Glu Glu Gly Ser 
    610                 615                 620                 


Ile Phe Lys Gly Gly Tyr Leu Val Asp Asn Asn His Asn Pro Leu Gly 
625                 630                 635                 640 


Ile Thr Asp Pro Thr Ser Leu Ser Glu Leu Val Asn Asn Pro Thr Asn 
                645                 650                 655     


Gly Phe Thr Trp Gln Thr Ile Gly Ala Lys Val Gln Asn Asn Lys Val 
            660                 665                 670         


Ala Phe Ser Pro Asn Gly Asp Gly Ile Ser Asp Thr Ile Thr Pro Tyr 
        675                 680                 685             


Val Phe Thr Lys Gln Asn Leu Lys Gln Val Ile Ala Gln Ile Leu Asp 
    690                 695                 700                 


Gln Asp Asp Lys Val Met Arg Val Ile Asp Gln Glu Thr Asp Thr Thr 
705                 710                 715                 720 


Lys Ser Phe Leu Glu Val Gly Ser Thr Thr Asn Ala Asp Leu Ala Lys 
                725                 730                 735     


Ser Ile Ser Met Phe Leu Asn Pro Asp Lys Leu Lys Trp Asp Gly Gln 
            740                 745                 750         


Val Tyr Asp Gln Thr Thr Gly Gln Met Val Pro Ala Lys Asp Gly Ile 
        755                 760                 765             


Tyr Thr Tyr Arg Leu Ile Gly Met Thr Tyr Thr Pro Gly Glu Asn Asn 
    770                 775                 780                 


Met Gln Thr Met Ser Leu Pro Val Ala Val Asp Thr Ile Lys Pro Thr 
785                 790                 795                 800 


Leu Ser Asn Leu Ala Tyr Ser Asp Gly Lys Leu Thr Ala Asp Tyr Ser 
                805                 810                 815     


Asp Gln Gly Val Gly Phe Thr Ala Tyr Ser Gln Ala Lys Leu Thr Ile 
            820                 825                 830         


Gly Ser Ala Thr Tyr Gly Ile Pro Leu Asn His Asp Asn Lys Ala Thr 
        835                 840                 845             


Thr Gly Thr Ile Asn Tyr Gln Leu Asn Asp Asp Gln Leu Ala Asn Leu 
    850                 855                 860                 


Lys Thr Gly Glu Gly Lys Val Thr Leu Thr Ile Thr Asp Ala Ala Gly 
865                 870                 875                 880 


Asn Ser Asp Gln Gly Ser Ile Lys Ala Val Val Gly Glu Asn Lys Thr 
                885                 890                 895     


Ile Glu Ser Asn Phe Ile Trp Pro Gln Val Arg Trp Ser Met Pro Asp 
            900                 905                 910         


Thr Lys Gly Asn Leu Thr Arg Ser Asp Gly Arg Tyr Gln Ala Leu Thr 
        915                 920                 925             


Lys Asp Ser Thr Phe Thr Ala Gln Ala Met Val Pro Lys Gly Gln Asp 
    930                 935                 940                 


Tyr Ile Val Thr Ala Thr Asp Tyr Val Ser Asp Arg Gln Tyr Ile Gly 
945                 950                 955                 960 


Thr Leu Asp Lys Ala Thr Gly Ile Val Thr Phe Asn Ile Asp Ala Thr 
                965                 970                 975     


Gly Gln Pro Tyr Ala Asn Leu Thr Ile Ser Ala Ile Ala Arg Asp Ala 
            980                 985                 990         


Phe Gly Glu Phe Ile Lys Ser Pro  Lys Thr Glu Asp Phe  Ile Ile Phe 
        995                 1000                 1005             


Ile Lys  Lys Asn Ala Ala Ala  Tyr Ser Asn Ala Lys  Thr Gln Thr 
    1010                 1015                 1020             


Lys Pro  Phe Ala Asp Glu Ala  Thr Ala Ile Lys Gly  Ala Lys Phe 
    1025                 1030                 1035             


Phe Ser  Gly Ala Ala His Leu  Thr Gly Arg Ser Pro  Leu Thr Ser 
    1040                 1045                 1050             


Thr Lys  Gly Lys Met Ile Asn  Gly Ile Ala Phe Leu  Asp Leu Asn 
    1055                 1060                 1065             


Asn Asn  Lys Arg Thr Leu Val  Gly Ile Asp Ser Ala  Ser Thr Phe 
    1070                 1075                 1080             


Tyr Asp  Ala Lys Leu Lys Thr  Leu Thr Leu Arg Gly  Lys Val Ser 
    1085                 1090                 1095             


Asp Pro  Lys Asn Ser Lys Leu  Arg Ile Phe Val Thr  Pro Arg Gln 
    1100                 1105                 1110             


Asn Asp  Pro Gln Asn Glu Val  Thr Phe Ala Ala Asp  Gly Ser Phe 
    1115                 1120                 1125             


Ser Met  Thr Met Pro Cys Asn  Pro Thr Glu Glu Arg  Asn Ile Gly 
    1130                 1135                 1140             


Tyr Val  Leu Thr Thr Leu Asp  Lys Asp Gly Lys Glu  Lys Thr Asn 
    1145                 1150                 1155             


Gly Gly  Phe Leu Leu Leu Tyr  Met Asp Thr Thr Leu  Pro Thr Leu 
    1160                 1165                 1170             


Glu Leu  Ser Asp Ala Asp Ser  Met Lys Ile Asp Asp  Asp Gly Thr 
    1175                 1180                 1185             


Tyr Leu  Val Thr Thr Asp Ala  Asp Thr Phe Ser Ile  Lys Gly Ser 
    1190                 1195                 1200             


Val Thr  Asp Asn Ile Gly Gly  Tyr Arg Leu Tyr Ser  Asn Gly Asn 
    1205                 1210                 1215             


Asn Ile  Phe Thr Gln Gln Asn  Leu Ala Gly Phe Asn  Ala His Gln 
    1220                 1225                 1230             


Ser Ser  Ala Ala Pro Asn Gln  Leu Thr Asn Gly Tyr  Asn Pro Tyr 
    1235                 1240                 1245             


Gly Ala  Ala Ser Phe Asp Glu  Thr Tyr Gln Leu Thr  Asp Gly Leu 
    1250                 1255                 1260             


Asn Ile  Ile Thr Leu Gln Ala  Val Asp Gln Val Gly  Asn Thr Val 
    1265                 1270                 1275             


Thr Lys  Thr Phe Asn Val Thr  Lys Thr Pro Lys Leu  Leu Lys Glu 
    1280                 1285                 1290             


Glu Ser  Leu Asp Glu Leu Glu  Ile Thr Pro Glu Gln  Glu Asp Gln 
    1295                 1300                 1305             


Thr Pro  Lys Asn Asp Ala Gly  Glu Ala Pro Val Thr  Thr Ser Ser 
    1310                 1315                 1320             


Ser Asp  Glu Lys Ala Glu Val  Thr Pro Ser Thr Glu  Pro Thr Met 
    1325                 1330                 1335             


Val Asn  Pro Glu Asp Ser Lys  Val Glu Thr Ser Asn  Pro Val Val 
    1340                 1345                 1350             


Glu Ile  Asp Thr Ser Lys Glu  Ala Gln Ser Asp Gly  Asn Asp Asp 
    1355                 1360                 1365             


Thr Ala  Thr Asn Thr Pro Ala  Ser Val Thr Thr Ala  Val Asp Glu 
    1370                 1375                 1380             


Asn Pro  Val Asp Asn Ser Pro  Asn Ala Thr Thr Thr  Met Pro Asn 
    1385                 1390                 1395             


His Ala  Lys Gly Val Asp Ser  Asp Ala Glu Ala Thr  Glu Ala Thr 
    1400                 1405                 1410             


Asn Thr  Lys Asp Asn Thr Pro  Gly Thr Thr Ala Pro  Thr Asp Thr 
    1415                 1420                 1425             


Asp Pro  Thr Met Asp Lys Glu  Ser Pro Thr Lys Ser  Glu Val Asp 
    1430                 1435                 1440             


Pro Thr  Ala Thr Ser Leu Pro  Asp Ser Gln Val Val  Glu Thr Ala 
    1445                 1450                 1455             


Thr Glu  Thr Thr Val Asn Glu  Asp Lys Gly Asn Lys  Thr Asp Asp 
    1460                 1465                 1470             


Asp Glu  Pro Thr Ala Thr Asn  Leu Thr Thr Ser Lys  Asp Ser Ala 
    1475                 1480                 1485             


Ile Gln  Pro Lys Ser Asp Pro  Ala Ala Ser Leu Gln  Ser Asn Asp 
    1490                 1495                 1500             


Lys Ala  Val Glu Ala Ala Ile  Glu Asn Asp Lys Ile  Ala Glu Lys 
    1505                 1510                 1515             


Glu Gly  His Gln Ser Ala Asn  Thr Gln Pro Ala Ile  Thr Asp Val 
    1520                 1525                 1530             


Thr Thr  Asp Lys Asp Ser Ala  Val Lys Pro Glu Ile  Asp Pro Ala 
    1535                 1540                 1545             


Ala Ser  Ser Gln Ser Asn Asp  Lys Ala Val Glu Ala  Ala Met Glu 
    1550                 1555                 1560             


Asp Ser  Lys Ala Glu Asn Asp  Lys Gly Ser Lys Ser  Asp Ser Ala 
    1565                 1570                 1575             


Glu Thr  Asn Ile Ala Pro Thr  Met Ala Lys Asn Ser  Gly Val Lys 
    1580                 1585                 1590             


Ser Glu  Ile Asp Leu Thr Ala  Ile Ala Pro Arg Asp  Asn Thr Ala 
    1595                 1600                 1605             


Thr Ser  Ser Gly Thr Ala Lys  Glu Asn Ala Asp Val  Lys Asp Asp 
    1610                 1615                 1620             


Lys Gly  Asn Lys Thr Asp Thr  Val Glu Ser Ala Val  Thr Asp Thr 
    1625                 1630                 1635             


Glu Asp  Asp Asn Glu Gly Thr  Val Lys Ser Glu Ile  Glu Ser Val 
    1640                 1645                 1650             


Ala Thr  Thr Pro Ser Ser Asn  Thr Ala Thr Ala Thr  Glu Ile Thr 
    1655                 1660                 1665             


Lys Glu  Asn Thr Pro Thr Glu  Asp Glu Lys Asp Asn  Gln Val Asn 
    1670                 1675                 1680             


Val Val  Glu Thr Thr Asp Thr  His Pro Lys Pro Ile  Lys Asp Arg 
    1685                 1690                 1695             


Ala Thr  Lys Ser Glu Ile Glu  Ser Glu Ala Thr Ala  Pro Ser Lys 
    1700                 1705                 1710             


Thr Glu  Val Gly Glu Thr Val  Ala Glu Asp Ala Lys  Gly Glu His 
    1715                 1720                 1725             


Asp Lys  Ser Asn Lys Ser Asp  Asp Val Glu Pro Thr  Val Ser Asp 
    1730                 1735                 1740             


Arg Lys  Thr Asp Glu Asp Arg  Ala Ile Lys Ser Glu  Ser Asn Ala 
    1745                 1750                 1755             


Ser Ala  Ile Thr Pro Asn Glu  Asp Asn Ile Asp Glu  Thr Thr Val 
    1760                 1765                 1770             


Glu Glu  Ala Lys Ala Glu Asp  Asn Arg Glu Ala Ala  Ala Gly Thr 
    1775                 1780                 1785             


Ile Ala  Thr Val Ala Ala Asp  Pro Lys Ala Ser Glu  Asp Asn Ser 
    1790                 1795                 1800             


Val Lys  Ser Glu Met Asp Ala  Thr Thr Ile Ala Pro  Ile Asp Asn 
    1805                 1810                 1815             


Lys Ala  Ile Glu Thr Val Thr  Glu Thr Thr Gly Val  Glu Lys Val 
    1820                 1825                 1830             


Glu Ser  His Lys Ser Thr Asp  Thr Glu Ser Pro Val  Thr Asp Pro 
    1835                 1840                 1845             


Ala Ile  Asp Lys Asp Arg Ala  Val Asn Ser Asp Ile  Thr Pro Ala 
    1850                 1855                 1860             


Thr Ala  Ser Pro Thr Ala Asp  Lys Ala Pro Glu Ala  Thr Thr Glu 
    1865                 1870                 1875             


Ser Val  Asp Val Glu Asn Thr  Glu Ser His His Pro  Asp Ile Gly 
    1880                 1885                 1890             


Glu Thr  Ser Val Ser Asp Ser  Gln Ala Gly Lys Asp  Ser Ala Thr 
    1895                 1900                 1905             


Glu Ser  Lys Ile Asp Pro Lys  Ala Thr Pro Ser Ser  Asp Asn Thr 
    1910                 1915                 1920             


Thr Thr  Gly Ser Thr Val Glu  Ile Leu Thr Thr Gly  Ser Glu Gln 
    1925                 1930                 1935             


Asn Ser  Gln Ile Asp Thr Ser  Lys Thr Thr Val Thr  Pro Ala Thr 
    1940                 1945                 1950             


Asp Asp  Lys Lys Val Ser Ser  Glu Thr Ile Ala Pro  Ala Lys Thr 
    1955                 1960                 1965             


Ser Asp  Asp Thr Ala Glu Phe  Gly Thr Ala Thr Thr  Thr Ser Gly 
    1970                 1975                 1980             


Gln Asn  Thr Leu Thr Lys Thr  Glu Val Glu Ser Ser  Asn His Ala 
    1985                 1990                 1995             


Thr Asn  His Pro Asp Thr Thr  Asp Ser Ser Thr Asp  Ala Thr Ser 
    2000                 2005                 2010             


Gln Pro  Asp Glu Pro Thr Ile  Ser Ile Glu Val Thr  Lys Pro Val 
    2015                 2020                 2025             


Pro Thr  Thr Pro Ser Thr Glu  Asp Asn Pro Val Gln  Pro Asn Val 
    2030                 2035                 2040             


Asp Gln  Lys Val Ser Asp Gln  Lys Ser Asp Lys Asp  Asn Gln Asp 
    2045                 2050                 2055             


Asn Pro  Thr Ala Ile Glu Lys  Asn Pro Lys Ser Lys  Val Thr Asp 
    2060                 2065                 2070             


Asp Glu  Glu Thr Ile Ser Lys  Thr Arg Gln Lys Asp  Pro Lys Ser 
    2075                 2080                 2085             


Asn Ile  Val Glu Lys Glu Asp  Asp Thr Ile Leu Val  Val Gln Lys 
    2090                 2095                 2100             


Gly Leu  Lys Ala Lys Thr Val  Lys Asp Ala Glu Pro  Thr Ser Ser 
    2105                 2110                 2115             


Leu Asp  Gln Lys Thr Ser Ala  Leu Lys Gln Lys Glu  Ser Lys Glu 
    2120                 2125                 2130             


Lys Ala  Pro Ala Lys Ser Val  His Pro Thr Lys Ala  Ala Ala Lys 
    2135                 2140                 2145             


Thr Leu  Pro Pro Met Gly Met  Gln Asn Ser His Trp  Leu Gln Ala 
    2150                 2155                 2160             


Leu Gly  Ile Ala Leu Leu Gly  Met Val Phe Ala Leu  Ser Ile Gly 
    2165                 2170                 2175             


Leu Thr  Ser Lys Lys Lys His  Glu Lys Asn 
    2180                 2185             


<210>  57
<211>  819
<212>  PRT
<213>  Lactobacillus parafarraginis

<400>  57

Met Lys His Ile Phe Lys Ser Phe Gly Glu Thr Lys Arg His Pro Phe 
1               5                   10                  15      


Ile Ile Ala Thr Leu Leu Ala Ile Ser Thr Ile Gly Leu Phe Met Thr 
            20                  25                  30          


Thr Glu Met Thr Ala Thr Gln Ala Gln Ser Ile Lys Gln Pro Thr Thr 
        35                  40                  45              


Phe Ser Gln His Lys Pro Ala Lys Lys Pro Thr Lys Thr Asn Gln Thr 
    50                  55                  60                  


Thr Ser Phe Asn Gln Gln Arg Gln Ala Ala Leu Thr Arg Gly Asn Val 
65                  70                  75                  80  


Pro Thr Leu Trp Ser Gln Gly Tyr Gln Gly Gln Gly Met Val Ile Ala 
                85                  90                  95      


Val Ile Asp Ser Gly Ile Gln Asn His Pro Asp Leu Gly Leu Ser Asn 
            100                 105                 110         


Asn Gln Thr Ala Lys Ile Ser Lys Ala Asp Ala Gln Gln Leu Ile Ala 
        115                 120                 125             


Gln Lys Gly Tyr Gly Lys Tyr Ile Ser Pro Lys Ile Pro Phe Ala Tyr 
    130                 135                 140                 


Asp Tyr Val Asn Asn Asn Asn Asp Asp Thr Ala Ala Asp Ser Thr Ser 
145                 150                 155                 160 


Gly Phe His Gly Glu Glu Val Gly Gly Val Ala Ala Ala Asn Gly Val 
                165                 170                 175     


Glu Thr Asn Gln Ala Lys Tyr Met Lys Gly Val Ala Pro Gln Ala Gln 
            180                 185                 190         


Leu Leu Asn Leu Lys Val Phe Gly Gly Phe Ala Asp Glu Ile Pro Asn 
        195                 200                 205             


Asp Val Ala Arg Ala Ile His Asp Ala Val Asp Leu Gly Ala Asp Val 
    210                 215                 220                 


Ile Asn Leu Ser Leu Gly Leu Ala Gln Pro His Gln Ser Leu Thr Asp 
225                 230                 235                 240 


Glu Glu Gln Ala Ala Val Lys Tyr Ala Thr Asp His Gly Val Phe Val 
                245                 250                 255     


Ser Val Ala Gly Ser Asn Tyr Gly His Ala Gly Ser Leu Glu Thr Asn 
            260                 265                 270         


Ala Asn Asp Leu Ser Asp Ser Thr Thr Thr Thr Tyr Glu Pro Ala Asn 
        275                 280                 285             


Ser Gly Thr Ile Ala Asp Pro Gly Val Ala Asn Ser Ala Met Thr Val 
    290                 295                 300                 


Gly Ser Ala Asn Thr Lys Thr Gly Ser Lys Ser Ala Met Ser Ser Phe 
305                 310                 315                 320 


Ser Ala Trp Gly Pro Thr Pro Glu Phe Ala Phe Lys Pro Asp Ile Thr 
                325                 330                 335     


Ala Pro Gly Asp His Ile Ala Thr Ile Asp Glu Asn Lys Thr Tyr Thr 
            340                 345                 350         


Phe Asp Ser Gly Thr Ser Phe Ala Ser Pro Tyr Ile Ala Gly Ser Ala 
        355                 360                 365             


Ala Leu Val Leu Gln Arg Val His Lys Asp Gln Pro Asn Leu Lys Gly 
    370                 375                 380                 


Ala Ala Leu Val Asn Ala Ala Lys Val Ala Leu Met Asn Ala Ser Gln 
385                 390                 395                 400 


Pro Met Asn Asn Ser Gln Phe Pro Gly Glu Ile Val Ser Pro Arg Leu 
                405                 410                 415     


Gln Gly Ala Gly Val Val Asn Val Ala Asn Ala Ala Asn Leu Asn Ala 
            420                 425                 430         


Ala Ala Thr Asp Ala Ala Thr Gly Ser Gly Ala Val Ala Leu Arg Gln 
        435                 440                 445             


Ile Gly Gln Ile Thr Asn Phe Ser Leu Asn Val Thr Asn His Val Ala 
    450                 455                 460                 


Ile Pro Gln Thr Tyr Arg Val Asp Thr Thr Thr Gly Pro Asp Thr Glu 
465                 470                 475                 480 


Thr Arg Lys Ala Asp Lys Asn Gly Ile Gly Val Val His Asp Val Lys 
                485                 490                 495     


Ile Asn Gly Ala Ser Leu Thr Ala Ser Leu Pro Thr Ile Thr Val Asp 
            500                 505                 510         


Pro Gly Lys Thr Val Lys Leu Asp Phe Lys Leu Asp Leu Gly Ser Gln 
        515                 520                 525             


Ala Ala Arg Asn Lys Ile Ala Glu Gly Tyr Ile Ser Leu Val Asn Ser 
    530                 535                 540                 


Asp Ala Lys Gln Asn Leu Thr Ile Pro Tyr Met Gly Tyr Tyr Gly Asp 
545                 550                 555                 560 


Ala Thr Thr Glu Gln Ile Ile Asp Gln Pro Ala Asn Gln Thr Gly Ser 
                565                 570                 575     


Asp Phe Gly Gly Gly Tyr Met Ile Asp Asn His Asn Thr Pro Leu Gly 
            580                 585                 590         


Val Ser Asp Arg Thr Ser Leu Ala Ser Tyr Ile Asn Ala Gly Ser Pro 
        595                 600                 605             


Glu Thr Ala Ser Asn Arg Trp Asp Ala Thr Pro Gly Lys Val Asp Asp 
    610                 615                 620                 


Asp Lys Ile Ala Ile Ser Pro Asn Gly Asp Gly Lys Met Asp Val Ala 
625                 630                 635                 640 


Asn Pro Tyr Val Phe Ala Lys Gln Ser Leu Ala Lys Val Gln Ala Ala 
                645                 650                 655     


Ile Leu Asn Ser Lys Gly Gln Val Ile Arg Val Ile Asp Gln Glu Thr 
            660                 665                 670         


Asn Thr Asp Lys Ser Ile His Asp Leu Gly Ser Asp Ala Asn Asn Asp 
        675                 680                 685             


Leu Ala Leu Ser Val Ser Met Arg Pro Asn Pro Thr Ala Leu Thr Trp 
    690                 695                 700                 


Asn Gly Gln Ala Tyr Asp Arg Ala Thr Gly Lys Met Lys Val Val Pro 
705                 710                 715                 720 


Asp Gly Arg Tyr Gln Tyr Arg Ile Glu Thr Thr Asn Phe Asn Asp Gly 
                725                 730                 735     


Ala Asp Lys Val Gln Asp Trp Thr Leu Pro Val Gln Val Asp Thr Lys 
            740                 745                 750         


Ala Pro Lys Ile Val Lys Ala Thr Tyr His Arg Gly Arg Leu Thr Val 
        755                 760                 765             


Gly Tyr Arg Asp Ser Gly Val Gly Phe Thr Lys Leu Ser Ala Met Ala 
    770                 775                 780                 


Val Lys Val Gly Lys Lys Val Ala Gly Val Ser Leu Asn Asn Ser Gly 
785                 790                 795                 800 


Arg Gln Asn Gln Gly Ile Thr His Tyr Thr Leu Ser Lys Lys Leu Ser 
                805                 810                 815     


Lys Ile Ser 
            


<210>  58
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of Lactobacillus parafarraginis protease

<400>  58

Phe Met Thr Thr Glu Met Thr Ala Thr Gln Ala Gln Ser Ile Lys Gln 
1               5                   10                  15      


Pro Thr Thr Phe Ser Gln His Lys Pro Ala Lys Lys Pro Thr Lys Thr 
            20                  25                  30          


Asn Gln Thr Thr Ser Phe Asn Gln Gln Arg Gln Ala Ala Leu Thr Arg 
        35                  40                  45              


Gly Asn Val Pro Thr Leu Trp Ser Gln Gly Tyr Gln Gly Gln Gly Met 
    50                  55                  60                  


Val Ile Ala Val Ile Asp Ser Gly Ile Gln Asn His Pro Asp Leu Gly 
65                  70                  75                  80  


Leu Ser Asn Asn Gln Thr Ala Lys Ile Ser Lys Ala Asp Ala Gln Gln 
                85                  90                  95      


Leu Ile Ala Gln Lys Gly Tyr Gly Lys Tyr Ile Ser Pro Lys Ile Pro 
            100                 105                 110         


Phe Ala Tyr Asp Tyr Val Asn Asn Asn Asn Asp Asp Thr Ala Ala Asp 
        115                 120                 125             


Ser Thr Ser Gly Phe His Gly Glu Glu Val Gly Gly Val Ala Ala Ala 
    130                 135                 140                 


Asn Gly Val Glu Thr Asn Gln Ala Lys Tyr Met Lys Gly Val Ala Pro 
145                 150                 155                 160 


Gln Ala Gln Leu Leu Asn Leu Lys Val Phe Gly Gly Phe Ala Asp Glu 
                165                 170                 175     


Ile Pro Asn Asp Val Ala Arg Ala Ile His Asp Ala Val Asp Leu Gly 
            180                 185                 190         


Ala Asp Val Ile Asn Leu Ser Leu Gly Leu Ala Gln Pro His Gln Ser 
        195                 200                 205             


Leu Thr Asp Glu Glu Gln Ala Ala Val Lys Tyr Ala Thr Asp His Gly 
    210                 215                 220                 


Val Phe Val Ser Val Ala Gly Ser Asn Tyr Gly His Ala Gly Ser Leu 
225                 230                 235                 240 


Glu Thr Asn Ala Asn Asp Leu Ser Asp Ser Thr Thr Thr Thr Tyr Glu 
                245                 250                 255     


Pro Ala Asn Ser Gly Thr Ile Ala Asp Pro Gly Val Ala Asn Ser Ala 
            260                 265                 270         


Met Thr Val Gly Ser Ala Asn Thr Lys Thr Gly Ser Lys Ser Ala Met 
        275                 280                 285             


Ser Ser Phe Ser Ala Trp Gly Pro Thr Pro Glu Phe Ala Phe Lys Pro 
    290                 295                 300                 


Asp Ile Thr Ala Pro Gly Asp His Ile Ala Thr Ile Asp Glu Asn Lys 
305                 310                 315                 320 


Thr Tyr Thr Phe Asp Ser Gly Thr Ser Phe Ala Ser Pro Tyr Ile Ala 
                325                 330                 335     


Gly Ser Ala Ala Leu Val Leu Gln Arg Val His Lys Asp Gln Pro Asn 
            340                 345                 350         


Leu Lys Gly Ala Ala Leu Val Asn Ala Ala Lys Val Ala Leu Met Asn 
        355                 360                 365             


Ala Ser Gln Pro Met Asn Asn Ser Gln Phe Pro Gly Glu Ile Val Ser 
    370                 375                 380                 


Pro Arg Leu Gln Gly Ala Gly Val Val Asn Val Ala Asn Ala Ala Asn 
385                 390                 395                 400 


Leu Asn Ala Ala Ala Thr Asp Ala Ala Thr Gly Ser Gly Ala Val Ala 
                405                 410                 415     


Leu Arg Gln Ile Gly Gln Ile Thr Asn Phe Ser Leu Asn Val Thr Asn 
            420                 425                 430         


His Val Ala Ile Pro Gln Thr Tyr Arg Val Asp Thr Thr Thr Gly Pro 
        435                 440                 445             


Asp Thr Glu Thr Arg Lys Ala Asp Lys Asn Gly Ile Gly Val Val His 
    450                 455                 460                 


Asp Val Lys Ile Asn Gly Ala Ser Leu Thr Ala Ser Leu Pro Thr Ile 
465                 470                 475                 480 


Thr Val Asp Pro Gly Lys Thr Val Lys Leu Asp Phe Lys Leu Asp Leu 
                485                 490                 495     


Gly Ser Gln Ala Ala Arg Asn Lys Ile Ala Glu Gly Tyr Ile Ser Leu 
            500                 505                 510         


Val Asn Ser Asp Ala Lys Gln Asn Leu Thr Ile Pro Tyr Met Gly Tyr 
        515                 520                 525             


Tyr Gly Asp Ala Thr Thr Glu Gln Ile Ile Asp Gln Pro Ala Asn Gln 
    530                 535                 540                 


Thr Gly Ser Asp Phe Gly Gly Gly Tyr Met Ile Asp Asn His Asn Thr 
545                 550                 555                 560 


Pro Leu Gly Val Ser Asp Arg Thr Ser Leu Ala Ser Tyr Ile Asn Ala 
                565                 570                 575     


Gly Ser Pro Glu Thr Ala Ser Asn Arg Trp Asp Ala Thr Pro Gly Lys 
            580                 585                 590         


Val Asp Asp Asp Lys Ile Ala Ile Ser Pro Asn Gly Asp Gly Lys Met 
        595                 600                 605             


Asp Val Ala Asn Pro Tyr Val Phe Ala Lys Gln Ser Leu Ala Lys Val 
    610                 615                 620                 


Gln Ala Ala Ile Leu Asn Ser Lys Gly Gln Val Ile Arg Val Ile Asp 
625                 630                 635                 640 


Gln Glu Thr Asn Thr Asp Lys Ser Ile His Asp Leu Gly Ser Asp Ala 
                645                 650                 655     


Asn Asn Asp Leu Ala Leu Ser Val Ser Met Arg Pro Asn Pro Thr Ala 
            660                 665                 670         


Leu Thr Trp Asn Gly Gln Ala Tyr Asp Arg Ala Thr Gly Lys Met Lys 
        675                 680                 685             


Val Val Pro Asp Gly Arg Tyr Gln Tyr Arg Ile Glu Thr Thr Asn Phe 
    690                 695                 700                 


Asn Asp Gly Ala Asp Lys Val Gln Asp Trp Thr Leu Pro Val Gln Val 
705                 710                 715                 720 


Asp Thr Lys Ala Pro Lys Ile Val Lys Ala Thr Tyr His Arg Gly Arg 
                725                 730                 735     


Leu Thr Val Gly Tyr Arg Asp Ser Gly Val Gly Phe Thr Lys Leu Ser 
            740                 745                 750         


Ala Met Ala Val Lys Val Gly Lys Lys Val Ala Gly Val Ser Leu Asn 
        755                 760                 765             


Asn Ser Gly Arg Gln Asn Gln Gly Ile Thr His Tyr Thr Leu Ser Lys 
    770                 775                 780                 


Lys Leu Ser Lys Ile Ser 
785                 790 


