                         SEQUENCE LISTING

<110>  Myelopro Diagnostics and Research GmbH
 
<120>  Compounds targeting mutant calreticulin

<130>  228-5 PCT

<150>  EP 18 202 112.1
<151>  2018-10-23

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
    370                 375                 380                 


Lys Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp 
385                 390                 395                 400 


Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu 
                405                 410                 415     


Leu 
    


<210>  2
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Met Met Arg Thr Lys Met Arg Met Arg Arg Met Arg Arg Thr Arg 
1               5                   10                  15      


Arg Lys Met Arg Arg Lys Met Ser Pro Ala Arg Pro Arg Thr Ser Cys 
            20                  25                  30          


Arg Glu Ala Cys Leu Gln Gly Trp Thr Glu Ala 
        35                  40              


<210>  3
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Arg Arg Met Met Arg Thr Lys Met Arg Met Arg Arg Met Arg Arg 
1               5                   10                  15      


Thr Arg Arg Lys Met Arg Arg Lys Met Ser Pro Ala Arg Pro Arg Thr 
            20                  25                  30          


Ser Cys Arg Glu Ala Cys Leu Gln Gly Trp Thr Glu Ala 
        35                  40                  45  


<210>  4
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Thr Arg 
        355                 360                 365             


Arg Met Met Arg Thr Lys Met Arg Met Arg Arg Met Arg Arg Thr Arg 
    370                 375                 380                 


Arg Lys Met Arg Arg Lys Met Ser Pro Ala Arg Pro Arg Thr Ser Cys 
385                 390                 395                 400 


Arg Glu Ala Cys Leu Gln Gly Trp Thr Glu Ala 
                405                 410     


<210>  5
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  5

Asn Cys Arg Arg Met Met Arg Thr Lys Met Arg Met Arg Arg Met Arg 
1               5                   10                  15      


Arg Thr Arg Arg Lys Met Arg Arg Lys Met Ser Pro Ala Arg Pro Arg 
            20                  25                  30          


Thr Ser Cys Arg Glu Ala Cys Leu Gln Gly Trp Thr Glu Ala 
        35                  40                  45      


<210>  6
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
    370                 375                 380                 


Asn Cys Arg Arg Met Met Arg Thr Lys Met Arg Met Arg Arg Met Arg 
385                 390                 395                 400 


Arg Thr Arg Arg Lys Met Arg Arg Lys Met Ser Pro Ala Arg Pro Arg 
                405                 410                 415     


Thr Ser Cys Arg Glu Ala Cys Leu Gln Gly Trp Thr Glu Ala 
            420                 425                 430 


<210>  7
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Lys 
1               5                   10                  15      


Lys Lys Leu Arg Ile Lys Arg Met Met Met Thr Glu Met Lys Met Arg 
            20                  25                  30          


Thr Lys Lys Met Arg Arg Arg Lys Met Arg Lys Asn Pro Leu Ala Lys 
        35                  40                  45              


Pro Arg Met Ser Cys Arg Gly His Thr Thr Cys Leu Gln Gly Trp Thr 
    50                  55                  60                  


Glu Ala 
65      


<210>  8
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Ala Glu Lys Leu Arg Ile Lys Arg Met Met Met Thr Glu Met Lys 
1               5                   10                  15      


Met Arg Thr Lys Lys Met Arg Arg Arg Lys Met Arg Lys Asn Pro Leu 
            20                  25                  30          


Ala Lys Pro Arg Met Ser Cys Arg Gly His Thr Thr Cys Leu Gln Gly 
        35                  40                  45              


Trp Thr Glu Ala 
    50          


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  FAM

<400>  9
ggcaaggccc tgaggtgt                                                     18


<210>  10
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  10
ggcctcagtc cagccctg                                                     18


<210>  11
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly Trp 
1               5                   10                  15      


Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys Phe 
            20                  25                  30          


Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys Gly 
        35                  40                  45              


Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser Phe 
    50                  55                  60                  


Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr Val 
65                  70                  75                  80  


Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu Phe 
                85                  90                  95      


Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr Asn 
            100                 105                 110         


Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val His 
        115                 120                 125             


Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp Ile 
    130                 135                 140                 


Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val Arg 
145                 150                 155                 160 


Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu Ser 
                165                 170                 175     


Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile Lys 
            180                 185                 190         


Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys Ile 
        195                 200                 205             


Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu His 
    210                 215                 220                 


Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu Met 
225                 230                 235                 240 


Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys Gly 
                245                 250                 255     


Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr Trp 
            260                 265                 270         


Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser Ile 
        275                 280                 285             


Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln Val 
    290                 295                 300                 


Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu Ala 
305                 310                 315                 320 


Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala Ala 
                325                 330                 335     


Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys Glu 
            340                 345                 350         


Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp Lys 
        355                 360                 365             


Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp Lys 
    370                 375                 380                 


Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu Leu 
385                 390                 395                 400 


<210>  12
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly Trp 
1               5                   10                  15      


Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys Phe 
            20                  25                  30          


Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys Gly 
        35                  40                  45              


Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser Phe 
    50                  55                  60                  


Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr Val 
65                  70                  75                  80  


Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu Phe 
                85                  90                  95      


Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr Asn 
            100                 105                 110         


Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val His 
        115                 120                 125             


Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp Ile 
    130                 135                 140                 


Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val Arg 
145                 150                 155                 160 


Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu Ser 
                165                 170                 175     


Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Gly Ser Gly Asp Pro 
            180                 185                 190         


Ser Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp 
        195                 200                 205             


Gln Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp 
    210                 215                 220                 


Glu Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys 
225                 230                 235                 240 


Ala Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu 
                245                 250                 255     


<210>  13
<211>  320
<212>  PRT
<213>  Mus musculus

<400>  13

Asp Pro Ala Ile Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Ala Trp 
1               5                   10                  15      


Thr Asn Arg Trp Val Glu Ser Lys His Lys Ser Asp Phe Gly Lys Phe 
            20                  25                  30          


Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Leu Glu Lys Asp Lys Gly 
        35                  40                  45              


Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Lys Phe 
    50                  55                  60                  


Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr Val 
65                  70                  75                  80  


Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu Phe 
                85                  90                  95      


Pro Ser Gly Leu Asp Gln Lys Asp Met His Gly Asp Ser Glu Tyr Asn 
            100                 105                 110         


Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val His 
        115                 120                 125             


Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp Ile 
    130                 135                 140                 


Arg Ser Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val Arg 
145                 150                 155                 160 


Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu Ser 
                165                 170                 175     


Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile Lys 
            180                 185                 190         


Asp Pro Asp Ala Ala Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys Ile 
        195                 200                 205             


Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Gly Gly Ser 
    210                 215                 220                 


Gly Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly 
225                 230                 235                 240 


Thr Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Ala 
                245                 250                 255     


Asn Ile Tyr Ala Tyr Asp Ser Phe Ala Val Leu Gly Leu Asp Leu Trp 
            260                 265                 270         


Gln Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp 
        275                 280                 285             


Glu Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys 
    290                 295                 300                 


Ala Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu 
305                 310                 315                 320 


<210>  14
<211>  256
<212>  PRT
<213>  Mus musculus

<400>  14

Asp Pro Ala Ile Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Ala Trp 
1               5                   10                  15      


Thr Asn Arg Trp Val Glu Ser Lys His Lys Ser Asp Phe Gly Lys Phe 
            20                  25                  30          


Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Leu Glu Lys Asp Lys Gly 
        35                  40                  45              


Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Lys Phe 
    50                  55                  60                  


Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr Val 
65                  70                  75                  80  


Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu Phe 
                85                  90                  95      


Pro Ser Gly Leu Asp Gln Lys Asp Met His Gly Asp Ser Glu Tyr Asn 
            100                 105                 110         


Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val His 
        115                 120                 125             


Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp Ile 
    130                 135                 140                 


Arg Ser Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val Arg 
145                 150                 155                 160 


Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu Ser 
                165                 170                 175     


Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Gly Ser Gly 
            180                 185                 190         


Ser Gly Pro Asp Ala Asn Ile Tyr Ala Tyr Asp Ser Phe Ala Val Leu 
        195                 200                 205             


Gly Leu Asp Leu Trp Gln Val Lys Ser Gly Thr Ile Phe Asp Asn Phe 
    210                 215                 220                 


Leu Ile Thr Asn Asp Glu Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr 
225                 230                 235                 240 


Trp Gly Val Thr Lys Ala Ala Glu Lys Gln Met Lys Asp Lys Gln Asp 
                245                 250                 255     


<210>  15
<211>  65
<212>  PRT
<213>  Mus musculus

<400>  15

Ala Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu 
1               5                   10                  15      


Lys Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu 
            20                  25                  30          


Asp Lys Glu Asp Asp Asp Asp Arg Asp Glu Asp Glu Asp Glu Glu Asp 
        35                  40                  45              


Glu Lys Glu Glu Asp Glu Glu Glu Ser Pro Gly Gln Ala Lys Asp Glu 
    50                  55                  60                  


Leu 
65  


<210>  16
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu 
1               5                   10                  15      


Lys Glu Glu Arg Gly Gln Glu Ala 
            20                  


<210>  17
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu 
1               5                   10                  15      


Lys Glu Glu Gly Arg Gly Gln Glu Ala 
            20                  25  


