                         SEQUENCE LISTING

<110>  University of Copenhagen
 
<120>  Virally expressed inhibitors of PDZ domains, such as PICK1 and 
       uses thereof

<130>  P5036PC00

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  159
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA-GCN4p1-gl4-DATC5

<400>  1
atgtatccgt atgatgtgcc ggattatgcg ggcagccgca tgaaacagct ggaagataaa       60

gtggaagaac tgctgagcaa aaactatcat ctggaaaacg aagtggcgcg cctgaaaaaa      120

ctggtgggcg gcggcggcag ccattggctg aaagtgtaa                             159


<210>  2
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA-tag

<400>  2
tatccgtatg atgtgccgga ttatgcg                                           27


<210>  3
<211>  96
<212>  DNA
<213>  artificial sequence

<220>
<223>  GCN4p1 fragment

<400>  3
ggcagccgca tgaaacagct ggaagataaa gtggaagaac tgctgagcaa aaactatcat       60

ctggaaaacg aagtggcgcg cctgaaaaaa ctggtg                                 96


<210>  4
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  gLinker region (gl4 or GS4)

<400>  4
ggcggcggcg gcagc                                                        15


<210>  5
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  DATC5

<400>  5
cattggctga aagtg                                                        15


<210>  6
<211>  40
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4p1-GS4-DATC5

<400>  6

Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Gly 
            20                  25                  30          


Gly Gly Ser His Trp Leu Lys Val 
        35                  40  


<210>  7
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA-tag

<400>  7

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  8
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4p1 fragment

<400>  8

Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val 
            20                  25                  30  


<210>  9
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  gLinker region (GS4)

<400>  9

Gly Gly Gly Gly Ser 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  DATC5

<400>  10

His Trp Leu Lys Val 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variants of DATC5


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is a proteogenic or non-proteogenic amino acid, preferably H, L, 
       V, I,          

A; or is absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  is a proteogenic or non-proteogenic amino acid, preferably W, F, 
       S, T; or is absent;

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is a proteogenic or non-proteogenic amino acid, preferably L, V, 
       I, F, A, Y;

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is a proteogenic or non-proteogenic amino acid, preferably K, R, 
       S, T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is V, I, L or C

<400>  11

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  12
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  general sequence of leucine zipper


<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  is individually selected from any proteinogenic or 
       non-proteinogenic amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(14)
<223>  is individually selected from any proteinogenic or 
       non-proteinogenic amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (16)..(21)
<223>  is individually selected from any proteinogenic or 
       non-proteinogenic amino acid residue

<400>  12

Leu Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Leu 
            20          


<210>  13
<211>  159
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA-GCN4p1(7P14P)-gl4-DATC5

<400>  13
atgtatccgt atgatgtgcc ggattatgcg ggcagccgca tgaaacagct ggaaccgaaa       60

gtggaagaac tgctgccgaa aaactatcat ctggaaaacg aagtggcgcg cctgaaaaaa      120

ctggtgggcg gcggcggcag ccattggctg aaagtgtaa                             159


<210>  14
<211>  159
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA-GCN4p1-gl4-IETDV

<400>  14
atgtatccgt atgatgtgcc ggattatgcg ggcagccgca tgaaacagct ggaagataaa       60

gtggaagaac tgctgagcaa aaactatcat ctggaaaacg aagtggcgcg cctgaaaaaa      120

ctggtgggcg gcggcggcag catcgagacc gacgtgtaa                             159


<210>  15
<211>  159
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA-GCN4p1(7P14P)-gl4-IETDV

<400>  15
atgtatccgt atgatgtgcc ggattatgcg ggcagccgca tgaaacagct ggaaccgaaa       60

gtggaagaac tgctgccgaa aaactatcat ctggaaaacg aagtggcgcg cctgaaaaaa      120

ctggtgggcg gcggcggcag catcgagacc gacgtgtaa                             159


<210>  16
<211>  162
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA-GCN4p1-gl4-RRTTPV

<400>  16
atgtatccgt atgatgtgcc ggattatgcg ggcagccgca tgaaacagct ggaagataaa       60

gtggaagaac tgctgagcaa aaactatcat ctggaaaacg aagtggcgcg cctgaaaaaa      120

ctggtgggcg gcggcggcag cagaagaacc acccctgtgt aa                         162


<210>  17
<211>  162
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA-GCN4p1(7P14P)-gl4-RRTTPV

<400>  17
atgtatccgt atgatgtgcc ggattatgcg ggcagccgca tgaaacagct ggaaccgaaa       60

gtggaagaac tgctgccgaa aaactatcat ctggaaaacg aagtggcgcg cctgaaaaaa      120

ctggtgggcg gcggcggcag cagaagaacc acccctgtgt aa                         162


<210>  18
<211>  162
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA-GCN4p1-gl4-YKQTSV

<400>  18
atgtatccgt atgatgtgcc ggattatgcg ggcagccgca tgaaacagct ggaagataaa       60

gtggaagaac tgctgagcaa aaactatcat ctggaaaacg aagtggcgcg cctgaaaaaa      120

ctggtgggcg gcggcggcag ctacaagcag accagcgtgt aa                         162


<210>  19
<211>  162
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA-GCN4p1(7P14P)-gl4-YKQTSV

<400>  19
atgtatccgt atgatgtgcc ggattatgcg ggcagccgca tgaaacagct ggaaccgaaa       60

gtggaagaac tgctgccgaa aaactatcat ctggaaaacg aagtggcgcg cctgaaaaaa      120

ctggtgggcg gcggcggcag ctacaagcag accagcgtgt aa                         162


<210>  20
<211>  168
<212>  DNA
<213>  artificial sequence

<220>
<223>  SSO10A- gl4-HWLKV

<400>  20
atgtatccgt atgatgtgcc ggattatgcg ggcagcggcg aggagctgct ggaggacatc       60

aggaagttca acgagatgag gaagaacatg gaccagctga aggagaagat caacagcgtg      120

ctgagcatca ggcagggcgg cggcggcagc cattggctga aagtgtaa                   168


<210>  21
<211>  1431
<212>  DNA
<213>  artificial sequence

<220>
<223>  tdTomato

<400>  21
atggtgagca agggcgagga ggtcatcaaa gagttcatgc gcttcaaggt gcgcatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac      180

atcctgtccc cccagttcat gtacggctcc aaggcgtacg tgaagcaccc cgccgacatc      240

cccgattaca agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gtctggtgac cgtgacccag gactcctccc tgcaggacgg cacgctgatc      360

tacaaggtga agatgcgcgg caccaacttc ccccccgacg gccccgtaat gcagaagaag      420

accatgggct gggaggcctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc      480

gagatccacc aggccctgaa gctgaaggac ggcggccact acctggtgga gttcaagacc      540

atctacatgg ccaagaagcc cgtgcaactg cccggctact actacgtgga caccaagctg      600

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg ctccgagggc      660

cgccaccacc tgttcctggg gcatggcacc ggcagcaccg gcagcggcag ctccggcacc      720

gcctcctccg aggacaacaa catggccgtc atcaaagagt tcatgcgctt caaggtgcgc      780

atggagggct ccatgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc      840

tacgagggca cccagaccgc caagctgaag gtgaccaagg gcggccccct gcccttcgcc      900

tgggacatcc tgtcccccca gttcatgtac ggctccaagg cgtacgtgaa gcaccccgcc      960

gacatccccg attacaagaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg     1020

aacttcgagg acggcggtct ggtgaccgtg acccaggact cctccctgca ggacggcacg     1080

ctgatctaca aggtgaagat gcgcggcacc aacttccccc ccgacggccc cgtaatgcag     1140

aagaagacca tgggctggga ggcctccacc gagcgcctgt acccccgcga cggcgtgctg     1200

aagggcgaga tccaccaggc cctgaagctg aaggacggcg gccactacct ggtggagttc     1260

aagaccatct acatggccaa gaagcccgtg caactgcccg gctactacta cgtggacacc     1320

aagctggaca tcacctccca caacgaggac tacaccatcg tggaacagta cgagcgctcc     1380

gagggccgcc accacctgtt cctgtacggc atggacgagc tgtacaagta a              1431


<210>  22
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variants of DATC5


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  H, L, V, I, A; or is absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  is W, F, S, T; or is absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is L, V, I, F, A, Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is K, R, S, T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is V, I, L or C

<400>  22

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  23
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variants of DATC5


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is H, L, V, I, A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  is W, F, S, T

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is L, V, I, F, A, Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is K, R, S, T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is V, I, L or C

<400>  23

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variants of DATC5


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is H, V, I, A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  is W, F, S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is L, V, I

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is K, R, S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is V or C

<400>  24

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variants of DATC5


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is H, V, A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  is W or S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is L, V, I

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is K or R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is V

<400>  25

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  26
<211>  51
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA-GCN4p1-GS4-DATC5

<400>  26

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser Arg Met Lys Gln Leu 
1               5                   10                  15      


Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn 
            20                  25                  30          


Glu Val Ala Arg Leu Lys Lys Leu Val Gly Gly Gly Gly Ser His Trp 
        35                  40                  45              


Leu Lys Val 
    50      


<210>  27
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4p1(7P14P)

<400>  27

Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu Leu Leu Pro Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val 
            20                  25                  30  


<210>  28
<211>  40
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4p1(7P14P)-GS4-DATC5

<400>  28

Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu Leu Leu Pro Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Gly 
            20                  25                  30          


Gly Gly Ser His Trp Leu Lys Val 
        35                  40  


<210>  29
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Class I PBM

<400>  29

Ile Glu Thr Asp Val 
1               5   


<210>  30
<211>  40
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4-GS4-IETDV

<400>  30

Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Gly 
            20                  25                  30          


Gly Gly Ser Ile Glu Thr Asp Val 
        35                  40  


<210>  31
<211>  40
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4p1(7P14P)-GS4-IETDV

<400>  31

Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu Leu Leu Pro Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Gly 
            20                  25                  30          


Gly Gly Ser Ile Glu Thr Asp Val 
        35                  40  


<210>  32
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Class I PBM

<400>  32

Arg Arg Thr Thr Pro Val 
1               5       


<210>  33
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4p1-GS4-RRTTPV

<400>  33

Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Gly 
            20                  25                  30          


Gly Gly Ser Arg Arg Thr Thr Pro Val 
        35                  40      


<210>  34
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4p1(7P14P)-GS4-RRTTPV

<400>  34

Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu Leu Leu Pro Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Gly 
            20                  25                  30          


Gly Gly Ser Arg Arg Thr Thr Pro Val 
        35                  40      


<210>  35
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Class I PBM

<400>  35

Tyr Lys Gln Thr Ser Val 
1               5       


<210>  36
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4p1-GS4-YKQTSV

<400>  36

Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Gly 
            20                  25                  30          


Gly Gly Ser Tyr Lys Gln Thr Ser Val 
        35                  40      


<210>  37
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4p1(7P14P)-GS4-YKQTSV

<400>  37

Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu Leu Leu Pro Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Gly 
            20                  25                  30          


Gly Gly Ser Tyr Lys Gln Thr Ser Val 
        35                  40      


<210>  38
<211>  40
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4-GS4-GS4

<400>  38

Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  39
<211>  40
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4-GS4-V-to-D

<400>  39

Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Gly 
            20                  25                  30          


Gly Gly Ser His Trp Leu Lys Asp 
        35                  40  


<210>  40
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Class III PBM

<400>  40

Lys Val Asp Ser Val 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Class III PBM

<400>  41

Gly Lys Asp Tyr Val 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Class III PBM

<400>  42

Arg Lys Asp Tyr Val 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Class III PBM

<400>  43

Thr Ala Glu Met Phe 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Class III PBM

<400>  44

Gln Glu Asp Gly Ala 
1               5   


<210>  45
<211>  33
<212>  PRT
<213>  artificial sequence

<220>
<223>  (alpha4 helix of the SSO10a protein

<400>  45

Gly Glu Glu Leu Leu Glu Asp Ile Arg Lys Phe Asn Glu Met Arg Lys 
1               5                   10                  15      


Asn Met Asp Gln Leu Lys Glu Lys Ile Asn Ser Val Leu Ser Ile Arg 
            20                  25                  30          


Gln 
    


<210>  46
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  SSO10a-GS4-HWLKV

<400>  46

Gly Glu Glu Leu Leu Glu Asp Ile Arg Lys Phe Asn Glu Met Arg Lys 
1               5                   10                  15      


Asn Met Asp Gln Leu Lys Glu Lys Ile Asn Ser Val Leu Ser Ile Arg 
            20                  25                  30          


Gln Gly Gly Gly Gly Ser His Trp Leu Lys Val 
        35                  40              


<210>  47
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  example leucine zipper

<400>  47

Leu Val Lys Ala Glu His Gly Leu Asp Lys Val Glu Glu Gln Leu Glu 
1               5                   10                  15      


Val Ala Arg Ala Lys Leu 
            20          


<210>  48
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  gLinker3

<400>  48

Gly Gly Gly Ser 
1               


<210>  49
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  gLinker5

<400>  49

Gly Gly Gly Gly Ser Gly 
1               5       


<210>  50
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  gLinker6

<400>  50

Gly Gly Gly Gly Ser Gly Gly 
1               5           


