                         SEQUENCE LISTING

<110>  �Ϻ�Ԫ�����＼�����޹�˾
 
<120>  ���PD-1��ϵ��׵�������������Ӧ��

<130>  OP190911

<160>  22    

<170>  PatentIn version 3.2

<210>  1
<211>  235
<212>  PRT
<213>  �˹��ϳ�

<400>  1

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly 
        35                  40                  45              


Gln Asn Val Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Val Leu Ile Phe Asn Ala Gln Ser Leu Gln Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Ser Trp Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  2
<211>  470
<212>  PRT
<213>  �˹��ϳ�

<400>  2

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Gln Val Thr Leu Lys Glu Ser Gly Pro Ala 
            20                  25                  30          


Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly 
        35                  40                  45              


Phe Ser Leu Ser Thr Ser Gly Thr Cys Val Ser Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Ala Leu Glu Trp Leu Ala Thr Ile Cys Trp Glu Asp Ser 
65                  70                  75                  80  


Lys Gly Tyr Ser Thr Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Ala Val Leu Thr Met Thr Asn Met Asp Pro Val 
            100                 105                 110         


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Arg Glu Asp Ser Gly Tyr Phe 
        115                 120                 125             


Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
    210                 215                 220                 


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
225                 230                 235                 240 


Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            340                 345                 350         


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Leu Gly Lys 
465                 470 


<210>  3
<211>  121
<212>  PRT
<213>  �˹��ϳ�

<400>  3

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Thr Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Thr Ile Cys Trp Glu Asp Ser Lys Gly Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Ala 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Glu Asp Ser Gly Tyr Phe Trp Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  4
<211>  106
<212>  PRT
<213>  �˹��ϳ�

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Asn Val Gln Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Phe Asn Ala Gln Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  5
<211>  279
<212>  PRT
<213>  �˹��ϳ�

<400>  5

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly 
        35                  40                  45              


Gln Asn Val Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Val Leu Ile Phe Asn Ala Gln Ser Leu Gln Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Ser Trp Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
145                 150                 155                 160 


Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu 
                165                 170                 175     


Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Thr 
            180                 185                 190         


Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        195                 200                 205             


Ala Thr Ile Cys Trp Glu Asp Ser Lys Gly Tyr Ser Thr Ser Leu Lys 
    210                 215                 220                 


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Ala Val Leu 
225                 230                 235                 240 


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                245                 250                 255     


Arg Arg Glu Asp Ser Gly Tyr Phe Trp Phe Pro Tyr Trp Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser 
        275                 


<210>  6
<211>  840
<212>  DNA
<213>  �˹��ϳ�

<400>  6
atggatatga gagtaccagc tcagctgctg ggcctgctgc tcctgtggtt ccctggcagc     60

cggtgcgaca tccagatgac gcagagcccc tccagtctct ctgctagcgt gggcgacagg    120

gtcacaatta catgcagagc tggacagaac gtccagaatt atttggcctg gtaccagcag    180

aaacctggaa aggctccaaa ggtgttgatc ttcaatgcgc aatctctcca aacaggcgtg    240

ccctcccgct tctccggctc agggtctggc accgacttta cccttaccat ctctagcctt    300

cagcctgagg attttgctac ttactactgt cagcagtata attcctggcc tacatttggt    360

ggtggtacga aagtcgagat taagggtggt ggaggttctg gaggaggtgg aagtggtggc    420

ggaggaagcg gcggtggtgg ttcaggaggg ggagggtcag gggggggagg ctcccaagtt    480

acactcaagg aaagcggtcc ggcccttgta aagcccaccc agacactgac tctgacctgt    540

acattcagcg gcttcagcct gtcaacgtcc ggcacatgtg ttagctggat acgccagccc    600

ccggggaaag cactggagtg gctcgcgacc atctgctggg aagatagtaa agggtactct    660

acaagcctta aatcacgcct gaccatttca aaggatacta gtaagaatca ggccgtcctt    720

acaatgacca atatggatcc cgtcgacact gcaacatact attgtgcccg ccgggaagat    780

agcggatact tctggttccc ctactggggc caaggaactc tcgtgacagt cagttcctaa    840


<210>  7
<211>  279
<212>  PRT
<213>  �˹��ϳ�

<400>  7

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Gln Val Thr Leu Lys Glu Ser Gly Pro Ala 
            20                  25                  30          


Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly 
        35                  40                  45              


Phe Ser Leu Ser Thr Ser Gly Thr Cys Val Ser Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Ala Leu Glu Trp Leu Ala Thr Ile Cys Trp Glu Asp Ser 
65                  70                  75                  80  


Lys Gly Tyr Ser Thr Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Ala Val Leu Thr Met Thr Asn Met Asp Pro Val 
            100                 105                 110         


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Arg Glu Asp Ser Gly Tyr Phe 
        115                 120                 125             


Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                165                 170                 175     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            180                 185                 190         


Thr Ile Thr Cys Arg Ala Gly Gln Asn Val Gln Asn Tyr Leu Ala Trp 
        195                 200                 205             


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile Phe Asn Ala 
    210                 215                 220                 


Gln Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
                245                 250                 255     


Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Pro Thr Phe Gly Gly 
            260                 265                 270         


Gly Thr Lys Val Glu Ile Lys 
        275                 


<210>  8
<211>  840
<212>  DNA
<213>  �˹��ϳ�

<400>  8
atggacatga gagtcccagc ccagctgctt ggtctgttgc ttctctggct cccgggtgcc     60

cgctgccagg tgacgctgaa ggagtcaggc cctgccttgg ttaagcccac ccagaccctg    120

accctcacat gtaccttctc cgggttctca ttgtcaacct ccggcacttg tgtcagttgg    180

atcaggcaac cccctggcaa agcccttgag tggttggcta cgatttgctg ggaagacagt    240

aaaggatact caacaagcct caaatctcgg ctgaccatta gtaaagatac atccaagaac    300

caggcagtcc ttaccatgac caatatggac ccagtcgata ccgccaccta ctattgcgct    360

cgccgagagg attctggcta cttctggttc ccatattggg gccaaggaac acttgtgacc    420

gtatcaagtg gtggaggggg tagcggtgga ggtggaagtg gtggcggagg aagtggcgga    480

ggtgggtccg gaggcggcgg ctccggagga ggtggttcag atattcagat gacccagtcc    540

cccagctctc tgagtgcatc cgtcggcgat agagtgacta tcacatgtcg agccggacag    600

aacgtgcaaa attacctggc ctggtaccag cagaagccgg gtaaggctcc caaagtgctt    660

attttcaatg cccaatctct gcagaccggg gtgccaagcc ggtttagtgg ttctggctcc    720

ggtactgact tcacgcttac catttccagt ctgcaaccgg aggatttcgc tacatattac    780

tgccagcagt acaacagctg gccaaccttc gggggcggga caaaagttga aatcaagtaa    840


<210>  9
<211>  327
<212>  PRT
<213>  �˹��ϳ�

<400>  9

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  10
<211>  606
<212>  PRT
<213>  �˹��ϳ�

<400>  10

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly 
        35                  40                  45              


Gln Asn Val Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Val Leu Ile Phe Asn Ala Gln Ser Leu Gln Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Ser Trp Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
145                 150                 155                 160 


Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu 
                165                 170                 175     


Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Thr 
            180                 185                 190         


Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        195                 200                 205             


Ala Thr Ile Cys Trp Glu Asp Ser Lys Gly Tyr Ser Thr Ser Leu Lys 
    210                 215                 220                 


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Ala Val Leu 
225                 230                 235                 240 


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                245                 250                 255     


Arg Arg Glu Asp Ser Gly Tyr Phe Trp Phe Pro Tyr Trp Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        275                 280                 285             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    290                 295                 300                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
305                 310                 315                 320 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                325                 330                 335     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            340                 345                 350         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        355                 360                 365             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    370                 375                 380                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
385                 390                 395                 400 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                405                 410                 415     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            420                 425                 430         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        435                 440                 445             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    450                 455                 460                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
465                 470                 475                 480 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                485                 490                 495     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            500                 505                 510         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        515                 520                 525             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    530                 535                 540                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
545                 550                 555                 560 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                565                 570                 575     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            580                 585                 590         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        595                 600                 605     


<210>  11
<211>  1821
<212>  DNA
<213>  �˹��ϳ�

<400>  11
atggatatgc gggtgccggc acagctgttg gggctgctgc tcctctggtt tcctggctca     60

cgctgcgata tccagatgac tcagagtccc agttccctgt ctgcctctgt gggcgataga    120

gtcaccataa cctgtcgcgc cggacaaaac gtccaaaatt acctggcgtg gtaccagcag    180

aaaccaggaa aggccccaaa ggtcctgatt ttcaatgctc aaagcctcca gactggagtc    240

cccagccggt tctctggctc cggatctggc accgacttta ccttgaccat cagcagcctg    300

cagcccgagg atttcgcaac ctactattgt cagcagtata atagctggcc aacattcggg    360

ggcggcacta aagtcgagat caagggtgga ggaggctctg gtggcggggg ctcaggggga    420

ggaggaagcg gtggcggtgg ttctggcgga ggtggcagtg gtggtggcgg tagccaagta    480

accttgaagg agtccggtcc cgcactggtg aaacccacac aaacgcttac gctcacttgt    540

accttcagcg gttttagcct gtctacgtcc ggaacctgcg tttcttggat ccggcagcct    600

cccggcaagg ccctcgagtg gctggccacc atctgctggg aagactccaa aggttactca    660

accagtctta aaagtaggtt gacaatcagc aaggatacca gtaaaaatca ggcagttctt    720

accatgacaa acatggatcc cgtagataca gctacctact attgtgccag gcgagaagac    780

tccggttact tttggttccc ctactggggt caggggactc tggtcacggt cagctctgcc    840

tccaccaagg gcccttctgt gttccccctg gcaccatgta gccggtccac ctccgagagc    900

actgcagcgt tgggctgctt ggtgaaagac tattttcccg agcctgtaac tgtgagttgg    960

aacagcggcg ccctcacgag cggggtgcac acctttcccg cagtcttgca gagctccggt   1020

ctctattccc tttctagtgt tgttaccgtg ccgagcagct ctcttggcac caagacttac   1080

acctgcaatg ttgaccataa accgtctaat actaaagttg acaagagggt cgagagcaaa   1140

tacggcccac catgcccacc ttgcccagca cctgagttcc tgggcggccc ctcagtgttc   1200

ttgtttcccc caaagcctaa agacaccctg atgattagcc gcacacccga ggtgacttgc   1260

gtcgtggtcg atgtgagtca ggaagaccct gaagtgcagt tcaactggta tgtagacggg   1320

gttgaggtac acaacgcaaa gactaaacca cgcgaggaac agtttaatag tacgtaccgg   1380

gtggtgtccg tgcttacagt cctgcaccag gattggttga atggaaagga atataagtgc   1440

aaagtgagca ataaaggcct gccttcttct atcgagaaga caatatccaa agcaaaaggt   1500

caacctcggg agcctcaggt gtataccttg cccccgagcc aggaggaaat gacgaaaaat   1560

caggttagtc tgacgtgtct tgtgaagggc ttttacccat ctgatatcgc agtggagtgg   1620

gaaagcaacg ggcagcccga gaataactat aagacgaccc cgcccgtcct ggactcagat   1680

ggtagcttct tcctgtattc ccgcctgaca gttgacaaat ctcgctggca agaaggaaat   1740

gttttttcct gcagtgtcat gcatgaagcc ctgcacaacc attacacaca gaaaagcttg   1800

agcctgagtc tggggaagtg a                                             1821


<210>  12
<211>  606
<212>  PRT
<213>  �˹��ϳ�

<400>  12

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Gln Val Thr Leu Lys Glu Ser Gly Pro Ala 
            20                  25                  30          


Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly 
        35                  40                  45              


Phe Ser Leu Ser Thr Ser Gly Thr Cys Val Ser Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Ala Leu Glu Trp Leu Ala Thr Ile Cys Trp Glu Asp Ser 
65                  70                  75                  80  


Lys Gly Tyr Ser Thr Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Ala Val Leu Thr Met Thr Asn Met Asp Pro Val 
            100                 105                 110         


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Arg Glu Asp Ser Gly Tyr Phe 
        115                 120                 125             


Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
                165                 170                 175     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            180                 185                 190         


Thr Ile Thr Cys Arg Ala Gly Gln Asn Val Gln Asn Tyr Leu Ala Trp 
        195                 200                 205             


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile Phe Asn Ala 
    210                 215                 220                 


Gln Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
                245                 250                 255     


Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Pro Thr Phe Gly Gly 
            260                 265                 270         


Gly Thr Lys Val Glu Ile Lys Ala Ser Thr Lys Gly Pro Ser Val Phe 
        275                 280                 285             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    290                 295                 300                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
305                 310                 315                 320 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                325                 330                 335     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            340                 345                 350         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        355                 360                 365             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    370                 375                 380                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
385                 390                 395                 400 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                405                 410                 415     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            420                 425                 430         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        435                 440                 445             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    450                 455                 460                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
465                 470                 475                 480 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                485                 490                 495     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            500                 505                 510         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        515                 520                 525             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    530                 535                 540                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
545                 550                 555                 560 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                565                 570                 575     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            580                 585                 590         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        595                 600                 605     


<210>  13
<211>  1821
<212>  DNA
<213>  �˹��ϳ�

<400>  13
atggacatgc gggtccccgc tcaactgctg ggccttcttt tgctctggtt gccgggtgca     60

agatgccagg taaccctgaa agaatccgga ccggccttgg taaagccgac gcagaccctt    120

actctcacat gtacgtttag tggattctca ttgtctacat caggaacatg tgtcagctgg    180

atccggcagc cgcccggtaa agccctggag tggcttgcca caatatgttg ggaggatagc    240

aaaggatact ccacaagtct taagagtcgc ctgactatta gcaaagacac gtccaagaat    300

caggccgtgc tcaccatgac caatatggac ccagtagata ctgcgaccta ctattgcgct    360

agacgggaag attcagggta cttctggttc ccttactggg gacaggggac tctggttacc    420

gtgtcatctg gtggaggggg tagcggtgga ggtggaagtg gtggcggagg aagtggcgga    480

ggtgggtccg gaggcggcgg ctccggagga ggtggttcag atattcagat gacacagagc    540

ccttcttcac ttagtgcctc agtaggggac cgcgtcacta tcacatgccg ggccgggcag    600

aacgtgcaga actacttggc ttggtatcag cagaagcccg gaaaagcgcc caaagtgctg    660

atcttcaacg ctcagtcact gcagactgga gtgccttcca ggttttctgg tagcggctct    720

gggaccgatt tcacactcac aatctcttct ctgcagccag aggacttcgc cacttactac    780

tgccaacagt acaattcctg gcctactttt ggtggaggga caaaggtaga gattaaagca    840

agtaccaaag gaccatctgt cttccctctg gcaccatgca gccggagcac cagcgagtct    900

accgctgcgc tcggctgcct tgtgaaggac tacttcccag aacctgtgac tgtgtcatgg    960

aatagcggcg ctctgaccag tggagttcac accttccccg ctgtcctgca gagcagcgga   1020

ttgtactctc tctccagcgt ggtgaccgtg cccagttcct ccctcggtac taagacgtat   1080

acatgcaatg tggaccacaa gccctccaat accaaggtcg acaagcgggt agaatcaaaa   1140

tatgggccgc cttgtccccc ctgccctgct cctgagtttc tcggagggcc cagcgtcttc   1200

ctctttccac ctaagccaaa agatacactg atgatctccc ggaccccgga ggtgacatgt   1260

gtggtggtgg atgtgtccca ggaggatcct gaggtgcagt ttaactggta cgtcgacgga   1320

gtcgaagtac acaacgccaa gacgaagccc cgagaggaac agtttaatag tacctataga   1380

gtcgtcagtg tgttgaccgt tcttcatcag gattggctga atgggaaaga atataaatgc   1440

aaggtttcca ataaaggact cccatcctca atcgagaaaa ccattagcaa agccaaagga   1500

cagccaagag agccccaagt ctacacgctg cccccttcac aggaagagat gaccaaaaac   1560

caggtttccc ttacctgctt ggtgaagggc ttttaccctt cagatatcgc ggtggagtgg   1620

gagagcaatg ggcagcccga gaataattac aaaacaacgc cgccagtgct tgattcagac   1680

ggctcatttt tcctgtactc tcgactgact gtggacaaaa gcaggtggca ggaggggaat   1740

gttttctctt gttctgtgat gcatgaggct ctccacaacc actacacaca aaagtcactg   1800

tccttgagcc tcggcaagta a                                             1821


<210>  14
<211>  22
<212>  PRT
<213>  �˹��ϳ�

<400>  14

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  15
<211>  30
<212>  PRT
<213>  �˹��ϳ�

<400>  15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  16
<211>  22
<212>  PRT
<213>  �˹��ϳ�

<400>  16

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys 
            20          


<210>  17
<211>  11
<212>  PRT
<213>  �˹��ϳ�

<400>  17

Arg Ala Gly Gln Asn Val Gln Asn Tyr Leu Ala 
1               5                   10      


<210>  18
<211>  7
<212>  PRT
<213>  �˹��ϳ�

<400>  18

Asn Ala Gln Ser Leu Gln Thr 
1               5           


<210>  19
<211>  8
<212>  PRT
<213>  �˹��ϳ�

<400>  19

Gln Gln Tyr Asn Ser Trp Pro Thr 
1               5               


<210>  20
<211>  9
<212>  PRT
<213>  �˹��ϳ�

<400>  20

Gly Phe Ser Leu Ser Thr Ser Gly Thr 
1               5                   


<210>  21
<211>  5
<212>  PRT
<213>  �˹��ϳ�

<400>  21

Cys Trp Glu Asp Ser 
1               5   


<210>  22
<211>  10
<212>  PRT
<213>  �˹��ϳ�

<400>  22

Glu Asp Ser Gly Tyr Phe Trp Phe Pro Tyr 
1               5                   10  


